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Sample records for healthy russian population

  1. Consumption of healthy foods and associated socio-demographic factors among Russian, Somali and Kurdish immigrants in Finland.

    Science.gov (United States)

    Adebayo, Folasade A; Itkonen, Suvi T; Koponen, Päivikki; Prättälä, Ritva; Härkänen, Tommi; Lamberg-Allardt, Christel; Erkkola, Maijaliisa

    2017-05-01

    We evaluated the consumption of healthy foods among Russian, Somali and Kurdish immigrants in Finland, and examined the relationship between socio-demographic factors and food consumption. We used data from the Migrant Health and Wellbeing Study (Maamu), a population-based health interview and examination survey in six different municipalities in Finland between 2010 and 2012. Altogether, 635 men and 737 women, aged 18-64 years, of Russian ( n = 527), Somali ( n = 337) and Kurdish ( n = 508) origin were included. The important socio-demographic determinants of healthy food consumption - sex, age, education, place of residence and household size - were assessed by logistic regression. Based on the consumption frequencies of recommended healthy foods - fruits, berries, vegetables, fish and rye bread - immigrants of Russian origin had higher consumption of healthy foods than their peers of Kurdish and Somali origin. Low consumption of fresh vegetables, fruits and berries was found among Somali immigrants. Sex and age were the most important determinants of healthy food consumption, as women and older age groups had diets closer to the national nutrition recommendations. High educational level was also positively associated with healthy food consumption. We found ethnic differences in the consumption of healthy foods among the immigrant groups of Russian, Somali and Kurdish origin in Finland. Socio-demographic factors, especially age, sex and education, seem to also play an important role in immigrants' food consumption. Further studies examining the consumption of fruits, berries and fresh vegetables among Somali immigrants in Finland are needed.

  2. Mental health of Russian population: new tendencies and old problems

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    Мihail М. Reshetnikov

    2015-03-01

    Full Text Available Contemporary situation with mental health is reviewed, and developments in psychiatry, psychotherapy and clinical psychology are monitored. Russian experience is discussed in the context of the world tendencies. In the situation of the unprecedented increase in psychopathology, insufficient attention has been paid to the crisis phenomena in psychiatry and psychology as well as the development of mental health institutions, which are still in need of specialists, and facilitation of health care programs for population. The author writes about the increase in the number of patients who need psychiatric or psychological care, lack of experts in the mental health system, low psychological culture of the population, lack of early diagnosis of predisposition to psychopathology. Multiple hypotheses on the causes of mental disorders are outlined in the paper. Among them, the theory of nervous exhaustion, the hypothesis that mental disorders are associated with impaired brain electrical activity, the theory of the special role of the frontal lobes in the emergence of psychopathology, the hypothesis of an imbalance of hormones, as an etiological factor of mental illness and others, are given account. The paper raises issues of mental disorders classification. The author also discusses the issue of chemical treatment and its isolated and uncontrolled use within mental disorders. However, the review is incomplete and tends to be an invitation for mental health specialists to further discuss the issues mentioned in the paper.

  3. The population policy of the Russian Far East

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    Yu. A. Avdeev

    2017-01-01

    Full Text Available The purpose of the study: identify the current demographic situation in the Russian Far East over the past quarter century, to assess the effectiveness of those efforts at the federal and local levels, to identify problems and propose the sequence of their decision for the following discussion. Materials and methods. The initiative of the Ministry for the Development of the Russian Far East to develop a regional concept of the demographic policy, three scientific conferences on demographic development of the region (2015, 2016 and 2017 respectively, approved by the Government Decree the Concept of the Demographic Development of the Far East (from June 20, 2017 № 1298-r, on the one hand, give hope that the demographic catastrophe will be prevented in this part of the country, but on the other hand, there is a fear that the adopted document, a set of follow-up actions will not significantly alter steady demographic trend, as dozens of previous decisions could not do this. Therefore, a further search of non-usual steps for the impact on the demographic potential of the region is necessary. The results. Analysis of population structure by age and sex, their differentiation by territories show: relatively small generation of 90- ies, entering into the fertile age, leads to a decrease in the birth rate, which inevitably effect on the total population. This requires adjusting the choice of priorities of a demographic policy. Typological characteristics of the demographic behavior of the regions of the Federation, formed under the influence of natural and geographical conditions and the way of life of the population, are mandatory in the regional demographic policy. It is not enough to understand the need to improve the quality of life and create attractive conditions for migrants. Peculiarities of territorial organization of economy and population, with the population density (when a person per square km, also significantly affect the formation of

  4. Heart rate variability in healthy population

    International Nuclear Information System (INIS)

    Alamgir, M.; Hussain, M.M.

    2010-01-01

    Background: Heart rate variability has been considered as an indicator of autonomic status. Little work has been done on heart rate variability in normal healthy volunteers. We aimed at evolving the reference values of heart rate variability in our healthy population. Methods: Twenty-four hour holter monitoring of 37 healthy individuals was done using Holter ECG recorder 'Life card CF' from 'Reynolds Medical'. Heart rate variability in both time and frequency domains was analysed with 'Reynolds Medical Pathfinder Digital/700'. Results: The heart rate variability in normal healthy volunteers of our population was found in time domain using standard deviation of R-R intervals (SDNN), standard deviation of average NN intervals (SDANN), and Square root of the mean squared differences of successive NN intervals (RMSSD). Variation in heart rate variability indices was observed between local and foreign volunteers and RMSSD was found significantly increased (p<0.05) in local population. Conclusions: The values of heart rate variability (RMSSD) in healthy Pakistani volunteers were found increased compared to the foreign data reflecting parasympathetic dominance in our population. (author)

  5. Russian Subjects on the Territory of the Grand Duchy of Finland (according to the Russian and Finnish Population Statistics of the late 19th century

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    Sergey G. Kashchenko

    2017-03-01

    Full Text Available Historical demographic research plays an important role in multi-disciplinary projects in historical, social and political sciences at the moment. It is of great importance for migration and social policy studies and also concerns economics, material and intellectual culture and inter-ethnic and inter-faith relations. The border regions with high population mobility are of particular interest. The search in the Russian State Historical Archive uncovered a complex of primary census material concerning the Russian population in the Grand Duchy of Finland. Thus it became possible to introduce previously unstudied documents, containing data on the Russian subjects, mainly military men, stationed at Helsinki, Sveaborg, Tavastgus, Torneo and a number of other garrisons into scientific use. Russian military men in those towns comprised quite a noticeable element in the composition of the population. It is no doubt that Russian officers and their family members were part of the town elite according to their social status, life experience, and level of education. Consequently the primary documents of the 1897 census give us a unique opportunity to see the demographic situation of the Russian garrisons accommodated in the Vyborg Governorate in the end of the 19th century from the inside, and add living colors related to biographies of certain people to the dry statistical picture which describes the population of the town.

  6. State report on the population health in the Russian Federation in 1995

    International Nuclear Information System (INIS)

    Arkhangel'skaya, E.F.; Demidov, N.A.

    1997-01-01

    Medico-demographic indices of the health of Russian Federation for 1987-1995 are presented. Dynamics of life conditions affecting the medico-demographic indices is considered. Disease incidence of the population is analysed. Special attention is paid to the problem of minimization of the Chernobyl accident medical consequences as well as malignant and mental diseases

  7. [The development of mass physical culture and sports in the constituent entities of the Russian Federation as a factor of formation of the healthy life style].

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    Kakorina, E P; Rudiakova, S E

    2011-01-01

    Provision of proper conditions for the creation of healthy life style is a priority of the state policy in this country with special attention given to the development of the mass physical culture and sports. The present paper contains information on the proportion of the population of the Russian Federation regularly engaged in physical culture and sports, provision of necessary sport facilities, and budgetary expenditures for the purpose in different constituent entities of the country. Public satisfaction with the conditions available for mass physical education and sports is discussed. Taking into account the low average life expectancy of the country's population and the increasing morbidity and traumaticity rates among the younger generation, it appears impossible to address the global challenge of improving the health of the nation without promotion of mass physical culture and sports and renewal of interest in these activities among the general population.

  8. ASSESSMENT OF EFFICIENCY OF APPLICATION OF TOOLS OF CARRYING OUT THE ALL-RUSSIAN POPULATION CENSUS OF 2020

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    Oleg V. Manzhula

    2014-01-01

    Full Text Available At a stage of preparation for the All-Russian population census of 2020 it is necessary to develop methodical and technological support of processes of carrying out census for increase of reliability of data collection and quality of information processing of population census of the Russian Federation with use of modern information and communication technologies, and also a technique of an assessment of efficiency of application of tools of carrying out census

  9. Persistent organic pollutants in maternal blood plasma and breast milk from Russian arctic populations.

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    Klopov, V; Odland, J O; Burkow, I C

    1998-10-01

    Under the auspices of Arctic Monitoring and Assessment Programme (AMAP), a Russian-Norwegian co-operation project was established to assess the exposure of delivering women to persistent organic pollutants (POPs) in Arctic areas of Russia. In the period 1993-95 blood and breast milk samples were collected from 94 delivering women in Yamal and Tajmyr Autonomous Regions of Siberia. Concentrations of chlorinated pesticides and polychlorinated biphenyls (PCBs) were determined by high resolution gas chromatography with electron capture detection. The POP levels in maternal plasma among the non-indigenous women were higher than the native population, especially in total PCB, HCHs (hexachlorocyclohexanes) and the DDT-group. The dietary questionnaires showed that the non-indigenous populations consumed considerably less local food items like reindeer meat and fresh water fish. There was no correlation between local food consumption and elevated levels of pollutants. Even if the indigenous groups had lower concentrations of the most important pollutants than the non-indigenous population, they were still higher than the levels measured in the Scandinavian countries of the AMAP-study and up to levels of medical concern. The most important sources of organic pollutants for the Russian Arctic populations of Yamal and Tajmyr seems to be imported food from other areas of Russia and local use of pesticides. It must be a high priority concern to further elucidate these trends and initiate prophylactic measures for the exposed population groups.

  10. CURRENT TRENDS OF THE PROVISION FOR RADIATION SAFETY OF THE POPULATION OF THE RUSSIAN FEDERATION

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    G. G. Onishenko

    2014-01-01

    Full Text Available P.V.Ramzaev”The article is devoted to the actual issues ofRussian Federationpopulation radiation safety providing at the present stage. The important role of radiation-hygienic passportization is underlined in the process of the obtaining of objective information of radiation situation in the country, of population exposure doses from the all sources: artificial and natural, from the use of ionizing irradiation sources in medicine. The leading role is shown of the natural ionizing irradiation sources in the level of the country population exposure. The main directions of activities are stated aimed on the decreasing of population exposure doses from the natural sources. The brief characteristics is given of the radiation situation on the territories radioactively contaminated after the accident on the Chernobyl NPP, in the Pacific Ocean basin after the accident on the “Fukushima-1”NPP, of the main measures for radiation protection providing and for counteraction to radiation terrorism during the period of international sports and mass actions which were carried out in Russia in the last years (XXVII World Summer Universiade in2013 inKazan, XXII Olympic and XI Winter Paralympics Games in2014 inSochi. The most important tasks are defined for the improvement ofRussian Federationpopulation radiation safety at the present stage.

  11. EL POPULISMO, UNA INVENCIÓN RUSA / The populism, a Russian invention

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    Camila Arbuet

    2016-12-01

    Full Text Available Populism started as a program and a Russian problem. Its germination process and its links with the socialist projects of the late nineteenth and early twentieth century –largely forgotten by contemporary theorists– sheds light on its historical particularity. A peculiarity that, will argue, has been completely neglected to provide an analytical matrix, as flexible as the intentions of the user shift. This paper attempts to find in this historic start some reading keys that allow pecise a concept that has lost all theoretical effectiveness. In the analytical proposal of this article we will go against the Laclau’s thesis in which he argued that populism is “a way to build the political”, we peopose that populism in any case contains an essential question to all emancipatory politics, a question that challenged us again: What if there is not the subject of the revolution?

  12. Serotonergic gene polymorphisms (5-HTTLPR, 5HTR1A, 5HTR2A), and population differences in aggression: traditional (Hadza and Datoga) and industrial (Russians) populations compared.

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    Butovskaya, Marina L; Butovskaya, Polina R; Vasilyev, Vasiliy A; Sukhodolskaya, Jane M; Fekhredtinova, Dania I; Karelin, Dmitri V; Fedenok, Julia N; Mabulla, Audax Z P; Ryskov, Alexey P; Lazebny, Oleg E

    2018-04-16

    Current knowledge on genetic basis of aggressive behavior is still contradictory. This may be due to the fact that the majority of studies targeting associations between candidate genes and aggression are conducted on industrial societies and mainly dealing with various types of psychopathology and disorders. Because of that, our study was carried on healthy adult individuals of both sex (n = 853). Three populations were examined: two traditional (Hadza and Datoga) and one industrial (Russians), and the association of aggression with the following polymorphisms 5-HTTLPR, rs6295 (5HTR1A gene), and rs6311 (5HTR2A gene) were tested. Aggression was measured as total self-ratings on Buss-Perry Aggression Questionnaire. Distributions of allelic frequencies of 5-HTTLPR and 5HTR1A polymorphisms were significantly different among the three populations. Consequently, the association analyses for these two candidate genes were carried out separately for each population, while for the 5HTR2A polymorphism, it was conducted on the pooled data that made possible to introduce ethnic factor in the ANOVA model. The traditional biometrical approach revealed no sex differences in total aggression in all three samples. The three-way ANOVA (μ + 5-HTTLPR + 5HTR1A + 5HTR2A +ε) with measures of self-reported total aggression as dependent variable revealed significant effect of the second serotonin receptor gene polymorphism for the Hadza sample. For the Datoga, the interaction effect between 5-HTTLPR and 5HTR1A was significant. No significant effects of the used polymorphisms were obtained for Russians. The results of two-way ANOVA with ethnicity and the 5HTR2A polymorphism as main effects and their interactions revealed the highly significant effect of ethnicity, 5HTR2A polymorphism, and their interaction on total aggression. Our data provided obvious confirmation for the necessity to consider the population origin, as well as cultural background of tested individuals, while

  13. [Population genetic study of Russian cosmonauts and test subjects: genetic demographic parameters and immunogenetic markers].

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    Kurbatova, O L; Pobedonostseva, E Iu; Prokhorovskaia, V D; Kholod, O N; Evsiukov, A N; Bogomolov, V V; Voronkov, Iu I; Filatova, L M; Larina, O N; Sidorenko, L A; Morgun, V V; Kasparanskiĭ, R R; Altukhov, Iu P

    2006-10-01

    Genetic demographic characteristics and immunogenetic markers (blood groups ABO, Rhesus, MNSs, P, Duffy, Kidd, and Kell) have been studied in a group of 132 Russian cosmonauts and test subjects (CTSG). Analysis of pedigrees has shown a high exogamy in the preceding generations: almost half of the subjects have mixed ethnic background. According to the results of genetic demographic analysis, a sample from the Moscow population was used as control group (CG). Comparison between the CTSG and CG has demonstrated significant differences in genotype frequencies for several blood group systems. The CTSG is characterized by a decreased proportion of rare interlocus genotypic combinations and an increased man heterozygosity. Analysis of the distributions of individual heterozygosity for loci with codominant expression of alleles has shown that highly heterozygous loci are more frequent in the CTSG. Taking into account that the CTSG has been thoroughly selected from the general population, it is concluded that heterozygosity is related to successful adaptation to a space flight.

  14. Influence of facial skin ageing characteristics on the perceived age in a Russian female population.

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    Merinville, E; Grennan, G Z; Gillbro, J M; Mathieu, J; Mavon, A

    2015-10-01

    The desire for a youthful look remains a powerful motivator in the purchase of cosmetics by women globally. To develop an anti-ageing solution that targets the need of end consumers, it is critical to understand which signs of ageing really matter to them and which influence their age perception. To date, such research has not been performed in a Russian population. The aim of this work was to identify the signs of ageing that contribute the most to an 'older' or 'younger' look for Russian women aged 40 years old and above. The age of 203 Russian female volunteers was estimated from their standard photographs by a total of 629 female naïve assessors aged 20-65 years old. Perceived age data were related to 23 facial skin features previously measured using linear correlation coefficients. Differences in average severity of the correlating skin ageing features were evaluated between women perceived older and women perceived younger than their chronological age. Volunteers' responses to a ranking question on their key ageing skin concerns previously collected were analysed to provide an additional view on facial ageing from the consumer perspective. Nine facial skin ageing features were found to correlate the most with perceived age out of the 23 measured. Such results showed the importance of wrinkles in the upper part of the face (crow's feet, glabellar, under eye and forehead wrinkles), but also wrinkles in the lower half of the face associated with facial sagging (upper lip, nasolabial fold). Sagging was confirmed of key importance to female volunteers aged 41-65 years old who were mostly concerned by the sagging of their jawline, ahead of under eye and crow's feet wrinkle. The severity of hyperpigmented spots, red and brown, was also found to contribute to perceived age although to a weaker extent. By providing a clear view on the signs of ageing really matter to Russian women who are aged 40 years old and above, this research offers key information for the

  15. [Health problems of working-age population in the Russian Federation].

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    Izmerov, N F; Tikhonova, G I

    2010-01-01

    The paper deals with health problems of working-age population in the Russian Federation. According to foreign and domestic experts reduction of the able-bodied population and its fraction in the general population will be accompanied by ageing of labour force in the nearest two decades. Despite the growth of life expectancy in 2006-2007 demonstrated by disability, mortality and life expectancy indices for the age group of interest, its health status is considered to be critical. Mathematical simulation of mortality rates allowed for the assessment of potential years of life lost (PYLL) from leading causes of death among active working population. The data obtained provide a basis for the elaboration of medical and social programs aimed at increasing life expectancy. The most essential role in current negative tendencies in the health of active working population belongs to the deterioration of work conditions and safety at industrial enterprises coupled to low efficiency of occupational health prevention system accounting for the significantly reduced accessibility of health services. Restoration of occupational health system in Russia is of crucial importance. Experts of the Institute of Occupational Health have elaborated a draft National Action Plan designed to improve health protection of labour force in this country; its implementation would help to solve demographic problems and increase the amount and quality of labour force.

  16. Identifying the Social Structure and the Inequality in Monetary Income of Russian Population

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    Vyacheslav Nikolaevich Bobkov

    2017-12-01

    Full Text Available The article aims at identifying the social structure and the inequality in monetary income of the population in Russia. identification of the social groups with different levels of material well-being in a society with a high inequality in the distribution of living standard is a relevant topic. The integration of normative and statistical methods allows to consider the limitations of the existing model of the distribution of cash income and adjust the boundaries of social groups with different levels of material well-being. At the same time, we stay within the criteria for the social standards of the differentiation of living standards. The authors have corrected the specific weight of the Russian social groups with different levels of material well-being. To define these social groups, we have applied the system of normative consumer budgets for different level of material well-being. This paper discovers the intervals for the levels of income and consumption, which are not in contradiction with the normative approach and existing conditions of the Russian economic development. These intervals are advisable for the identification of the social groups with different levels of life. The proposed tools allow to integrate the measurements into the international system and define the place of Russia in terms of economic inequalities among other countries. The authors have assessed the weights of the different social groups, their share in the total volume of monetary income and their polarization in terms of living standards. The main conclusions of the article can be used as a theoretical, methodological and practical basis for identifying social structures in terms of living standards, determining their numbers and economic inequality. The research results can be introduced into the statistical monitoring of the living standards of the population.

  17. Vitamin D in the healthy European paediatric population

    DEFF Research Database (Denmark)

    Braegger, Christian; Campoy, Cristina; Colomb, Virginie

    2013-01-01

    In recent years, reports suggesting a resurgence of vitamin D deficiency in the Western world, combined with various proposed health benefits for vitamin D supplementation have resulted in increased interest from healthcare professionals, the media and the public. The aim of this position paper...... is to summarize the published data on vitamin D intake and prevalence of vitamin D deficiency in the healthy European paediatric population, to discuss health benefits of vitamin D and to provide recommendations for the prevention of vitamin D deficiency in this population. Vitamin D plays a key role in calcium...

  18. Echocardiographic chamber quantification in a healthy Dutch population.

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    van Grootel, R W J; Menting, M E; McGhie, J; Roos-Hesselink, J W; van den Bosch, A E

    2017-12-01

    For accurate interpretation of echocardiographic measurements normative data are required, which are provided by guidelines. For this article, the hypothesis was that these cannot be extrapolated to the Dutch population, since in Dutch clinical practice often higher values are found, which may not be pathological but physiological. Therefore this study aimed to 1) obtain and propose normative values for cardiac chamber quantification in a healthy Dutch population and 2) determine influences of baseline characteristics on these measurements. Prospectively recruited healthy subjects, aged 20-72 years (at least 28 subjects per age decade, equally distributed for gender) underwent physical examination and 2D and 3D echocardiography. Both ventricles and atria were assessed and volumes were calculated. 147 subjects were included (age 44 ± 14 years, 50% female). Overall, feasibility was good for both linear and volumetric measurements. Linear and volumetric parameters were consistently higher than current guidelines recommend, while functional parameters were in line with the guidelines. This was more so in the older population. 3D volumes were higher than 2D volumes. Gender dependency was seen in all body surface area (BSA) corrected volumes and with increasing age, ejection fractions decreased. This study provides 2D and 3D echocardiographic reference ranges for both ventricles and atria derived from a healthy Dutch population. BSA indexed volumes are gender-dependent, age did not influence ventricular volumes and a rise in blood pressure was independently associated with increased right ventricular volumes. The higher volumes found may be indicative for the Dutch population being the tallest in the world.

  19. CONSTRUCTION OF STATISTICAL MODEL THE OVERALL POPULATION OF THE RUSSIAN FEDERATION ON THE BASIS OF RETROSPECTIVE FORECAST

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    Ol’ga Sergeevna Kochegarova

    2017-06-01

    Full Text Available The article considers the retrospective forecast of the total population of the Russian Federation for the period 2001–2017. comparative analysis of the actual values of the total population of the Russian Federation on 20.03.2017 according to the Federal state statistics service of the Russian Federation received the forecast value. Model selection forecasting was carried out by the method of selection of growth curves on the basis of correlation and regression analysis and least squares method. A quality selection of the regression equation was determined with the least error of approximation of time series levels. Analysis of the significance of the selected regression equation by statistical methods allows to make a conclusion about the right choice of models and the possibility of its use for population estimates. Purpose: to estimate the significance of selected regression equations for the forecast of the population. Methodology in article: the fitting of growth curves on the basis of correlation and regression analysis and least squares method. Results: received confirmation of the effectiveness of the constructed model for forecasts of demographic processes. Practical implications: the obtained results should be used when building forecasts of demographic processes.

  20. Using satellite telemetry to define spatial population structure in polar bears in the Norwegian and western Russian Arctic

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    Mauritzen, Mette; Derocher, Andrew E.; Wiig, Øystein; Belikov, Stanislav; Boltunov, Andrei N.; Garner, Gerald W.

    2002-01-01

    1. Animal populations, defined by geographical areas within a species’ distribution where population dynamics are largely regulated by births and deaths rather than by migration from surrounding areas, may be the correct unit for wildlife management. However, in heterogeneous landscapes varying habitat quality may yield subpopulations with distinct patterns in resource use and demography significant to the dynamics of populations.2. To define the spatial population structure of polar bears Ursus maritimus in the Norwegian and western Russian Arctic, and to assess the existence of a shared population between the two countries, we analysed satellite telemetry data obtained from 105 female polar bears over 12 years.3. Using both cluster analyses and home-range estimation methods, we identified five population units inhabiting areas with different sea-ice characteristics and prey availability.4. The continuous distribution of polar bear positions indicated that the different subpopulations formed one continuous polar bear population in the Norwegian and western Russian Arctic. Hence, Norway and Russia have a shared management responsibility.5. The spatial population structure identified will provide a guide for evaluating geographical patterns in polar bear ecology, the dynamics of polar bear–seal relationships and the effects of habitat alteration due to climate change. The work illustrates the importance of defining population borders and subpopulation structure in understanding the dynamics and management of larger animals.

  1. Several aspects of descriptive epidemiology of hematological malignancies in adult population of Ukraine, Belarus and Russian Federation after Chornobyl accident.

    Science.gov (United States)

    Guslitser, N; Zavelevich, M P; Koval, S V; Gluzman, D F

    2016-12-01

    Chornobyl impact on the health of adult population in Ukraine, Belarus and Russian Federation was a subject of several studies. However, the studies of the effects of Chornobyl on leukemia in adult populations in post-Soviet countries are scarce and the results are contradictory up to present. The results of the epidemiological studies of the oncohematological consequences of Chornobyl accident are briefly reviewed with particular focus on pre-Chornobyl and post-Chornobyl trends in leukemia incidence in Ukraine, Belarus and Russian Federation as well as in small territories of these countries with various levels of radionuclide contamination. This article is a part of a Special Issue entitled "The Chornobyl Nuclear Accident: Thirty Years After".

  2. Population pharmacokinetics of olprinone in healthy male volunteers

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    Kunisawa T

    2014-03-01

    Full Text Available Takayuki Kunisawa,1 Hidefumi Kasai,2 Makoto Suda,2 Manabu Yoshimura,3 Ami Sugawara,3 Yuki Izumi,3 Takafumi Iida,3 Atsushi Kurosawa,3 Hiroshi Iwasaki3 1Surgical Operation Department, Asahikawa Medical University Hospital, Hokkaido, Japan; 2Clinical Study Management Division, Bell Medical Solutions Inc, Tokyo, Japan; 3Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Hokkaido, Japan Background: Olprinone decreases the cardiac preload and/or afterload because of its vasodilatory effect and increases myocardial contractility by inhibiting phosphodiesterase III. Purpose: The objective of this study was to characterize the population pharmacokinetics of olprinone after a single continuous infusion in healthy male volunteers. Methods: We used 500 plasma concentration data points collected from nine healthy male volunteers for the study. The population pharmacokinetic analysis was performed using the nonlinear mixed effect model (NONMEM® software. Results: The time course of plasma concentration of olprinone was best described using a two-compartment model. The final pharmacokinetic parameters were total clearance (7.37 mL/minute/kg, distribution volume of the central compartment (134 mL/kg, intercompartmental clearance (7.75 mL/minute/kg, and distribution volume of the peripheral compartment (275 mL/kg. The interindividual variability in the total clearance was 12.4%, and the residual error variability (exponential and additive were 22.2% and 0.129 (standard deviation. The final pharmacokinetic model was assessed using a bootstrap method and visual predictive check. Conclusion: We developed a population pharmacokinetic model of olprinone in healthy male adults. The bootstrap method and visual predictive check showed that this model was appropriate. Our results might be used to develop the population pharmacokinetic model in patients. Keywords: phosphodiesterase III inhibitor, men, pharmacokinetic model

  3. [The influence of STAT4 rs7574865 (G/T) polymorphism on the risk of clinical and immunological phenotypes of systemic sclerosis in a Russian patient population: Results of a pilot study].

    Science.gov (United States)

    Krylov, M Yu; Ananyeva, L P; Koneva, О А; Starovoytova, M N; Desinova, O V; Ovsyannikova, O B; Aleksandrova, E N; Novikov, A A; Guseva, I A; Konovalova, N V; Varlamov, D A

    To examine the association of signal transducer and activator transcription 4 (STAT4) rs7574865 G/T polymorphism with a predisposition to systemic sclerosis (SSC) and associated clinical and autoimmune phenotypes in a Russian population. A total of 102 patients with SSC and 103 healthy individuals as controls were examined. STAT4 rs7574865 polymorphism was investigated by real-time polymerase chain reaction. The carriers of the T allele showed a statistically significant association with SSC, a diffuse form (DF), the presence of interstitial lung disease (ILD), cardiac injury (CI), and seropositivity for anti-topoisomerase I antibodies (ATA). The findings results confirm the important role of STAT4 gene in the predisposition to SSC and its phenotypes, such as DF, ILD, CI, and ATA in the Russian population.

  4. Working Memory Training in Schizophrenia and Healthy Populations

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    Linette Lawlor-Savage

    2014-09-01

    Full Text Available Cognitive deficits are consistently demonstrated in individuals with schizophrenia. Cognitive training involves structured exercises prescribed and undertaken with the intention of enhancing cognitive abilities such as attention, memory, and problem solving. Thus, cognitive training represents a potentially promising intervention for enhancing cognitive abilities in schizophrenia. However, cognitive training programs are numerous and heterogeneous, hence, the generalizability of training related outcomes can be challenging to assess. This article will provide a brief overview of current literature on cognitive training and explore how knowledge of working memory training in healthy populations can potentially be applied to enhance cognitive functioning of individuals with schizophrenia.

  5. Self-transcendence and correlates in a healthy population.

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    Coward, D D

    1996-01-01

    The purpose of this study was to document the presence of self-transcendence perspectives in a healthy population and to compare self-transcendence and related concepts with previous findings in elderly well persons and in those with life-threatening illness. Levels of self-transcendence, as assessed by the Self-Transcendence Scale and the Purpose-in-Life Test in a sample of 152 persons (mean age = 46 years), were similar to those found in other populations. Moderate correlations with self-transcendence and female gender; older age, and higher self-report of health status were found. Self-transcendence was strongly correlated with sense of coherence, self-esteem, hope, and variables assessing emotional well-being.

  6. Population pharmacokinetics of adefovir dipivoxil tablets in healthy Chinese volunteers.

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    Huang, Jihan; Zhang, Yaping; Huang, Xiaohui; Li, Lujin; Li, Yunfei; Wang, Kun; Yang, Juan; He, Yingchun; Lv, Yinghua; Zheng, Qingshan

    2014-01-01

    To develop a population pharmacokinetic model of adefovir dipivoxil in healthy volunteers and evaluate the effect of individual factors on the pharmacokinetics of adefovir dipivoxil. Plasma concentration data collected from 32 healthy Chinese subjects in a Phase I clinical study was pooled. Subjects received a single oral dose of 10 mg, 20 mg, or 30 mg adefovir dipivoxil, or multiple doses of 10 mg once a day for 9 days. Plasma concentrations of adefovir dipivoxil were measured using a validated liquid chromatography-mass spectrometric method. A nonlinear mixed-effect model was used to analyze the plasma concentration data of adefovir dipivoxil in healthy volunteers and to calculate the relevant parameters as well as inter- and intra-individual variability. The time course of adefovir dipivoxil concentration is best described by a first-order absorption and first-order elimination two-compartment model with lag time. The final estimate of total body clearance (CL) is 56.9 L/h and 78.7 L/h for single and multiple dosing regimen, respectively; the volume distribution of the central compartment (V2) is 106 L; inter-compartmental clearance (Q) is 220 L/h; volume distribution of the peripheral compartment (V3) is 498 L and 800 L for single and multiple dosing regimen, respectively; absorption rate is 0.509 h-1; and lag time is 0.315 hours. The inter-individual variabilities of CL and V2 were 22.4% and 58.9%, respectively. The proportional error of residual variability is 14.1% and the additive error is 0.30 ng/L. The final pharmacokinetic model was evaluated using a bootstrap method. A nonlinear mixed effect model for oral adefovir dipivoxil formulations was developed in healthy Chinese subjects. A multiple dosing regimen may significantly increase the body clearance and volume distribution of the peripheral compartment compared to a single dosing regimen. *These authors contribute equally to this work.

  7. RESULTS AND PROSPECTS OF SANITARY AND EPIDEMIOLOGICAL WELL-BEING ENSURING FOR THE POPULATION OF RUSSIAN FEDERATION

    Directory of Open Access Journals (Sweden)

    G. G. Onischenko

    2008-01-01

    Full Text Available The report states priority goals of sanitary and epidemiological service and shows the analysis of the Service's administrative reforms and structural changes from 1991 to 2007. It considers the existing regulatory and legal background on all aspects of hygiene and epidemiology as well as the Concept of the Federal Service Development. It analyses the work of Rospotrebnadzor  bodies in ensuring of sanitary and epidemiological well-being of the population, including current state of population radiation protection in Russian Federation.

  8. Zinc deficiency among a healthy population in Baghdad, Iraq

    International Nuclear Information System (INIS)

    Al-Timimi, D.; Al-Najjar, F.; Al-Sharbatti, Shatha S.

    2005-01-01

    To determine the prevalence of zinc deficiency and the current zinc status among a sample selected from the healthy population in Baghdad, Iraq. We carried out a community-based study in Baghdad City, Iraq from November through June 2002. We selected a sample of 2090 healthy subjects (aged 1 month to 85 years). We used a pre-tested questionnaire, designed to obtain information on gender, birth dates, height, weight, residence, habitual food consumption patterns, and social status. We performed laboratory assessment of serum zinc level, dietary assessment of food frequency and usual zinc intake. We considered subjects with serum zinc concentration of /-7.7 to 12.3 umol/l mild to moderately zinc deficient. The prevalence of zinc deficiency among the studied sample was 2.7%. We found mild to moderate zinc deficiency among 55.7% of the study sample. Dietary zinc intake assessment showed that 74.8% of the studied sample consumed less than the recommended intake, and in 62.3%, the intakes were deficient and grossly deficient. Mean daily zinc ranged from 5.2 mg in children to 8.5 mg in adults. We observed a high prevalence of mild to moderate zinc deficiency, with inadequate dietary zinc intake among a considerable proportion of the studied sample. Zinc supplementation may be an effective public health intervention means to improve the zinc status of the population. (author)

  9. Mycobacterium tuberculosis population in northwestern Russia: an update from Russian-EU/Latvian border region.

    Directory of Open Access Journals (Sweden)

    Igor Mokrousov

    Full Text Available This study aimed to characterize the population structure of Mycobacterium tuberculosis in Pskov oblast in northwestern Russia, to view it in the geographical context, to compare drug resistance properties across major genetic families. Ninety M. tuberculosis strains from tuberculosis (TB patients, permanent residents in Pskov oblast were subjected to LAM-specific IS6110-PCR and spoligotyping, followed by comparison with SITVITWEB and MIRU-VNTRplus databases. The Beijing genotype (n = 40 was found the most prevalent followed by LAM (n = 18, T (n = 13, Haarlem (n = 10, Ural (n = 5, and Manu2 (n = 1; the family status remained unknown for 3 isolates. The high rate of Beijing genotype and prevalence of LAM family are similar to those in the other Russian settings. A feature specific for M. tuberculosis population in Pskov is a relatively higher rate of Haarlem and T types. Beijing strains were further typed with 12-MIRU (followed by comparison with proprietary global database and 3 hypervariable loci QUB-3232, VNTR-3820, VNTR-4120. The 12-MIRU typing differentiated 40 Beijing strains into 14 types (HGI = 0.82 while two largest types were M2 (223325153533 prevalent throughout former USSR and M11 (223325173533 prevalent in Russia and East Asia. The use of 3 hypervariable loci increased a discrimination of the Beijing strains (18 profiles, HGI = 0.89. Both major families Beijing and LAM had similar rate of MDR strains (62.5 and 55.6%, respectively that was significantly higher than in other strains (21.9%; P = 0.001 and 0.03, respectively. The rpoB531 mutations were more frequently found in Beijing strains while LAM drug resistant strains mainly harbored rpoB516 and inhA -15 mutations. Taken together with a high rate of multidrug resistance among Beijing strains from new TB cases (79.3% versus 44.4% in LAM, these findings suggest the critical impact of the Beijing genotype on the current situation with MDR-TB in the

  10. Transcranial Doppler velocities in a large, healthy population.

    Science.gov (United States)

    Tegeler, Charles H; Crutchfield, Kevin; Katsnelson, Michael; Kim, Jongyeol; Tang, Rong; Passmore Griffin, Leah; Rundek, Tanja; Evans, Greg

    2013-07-01

    Transcranial Doppler (TCD) ultrasonography has been extensively used in the evaluation and management of patients with cerebrovascular disease since the clinical application was first described in 1982 by Aaslid and colleagues TCD is a painless, safe, and noninvasive diagnostic technique that measures blood flow velocity in various cerebral arteries. Numerous commercially available TCD devices are currently approved for use worldwide, and TCD is recognized to have an established clinical value for a variety of clinical indications and settings. Although many studies have reported normal values, there have been few recently, and none to include a large cohort of healthy subjects across age, race, and gender. As more objective, automated processes are being developed to assist with the performance and interpretation of TCD studies, and with the potential to easily compare results against a reference population, it is important to define stable normal values and variances across age, race, and gender, with clear understanding of variability of the measurements, as well as the yield from various anatomic segments. To define normal TCD values in a healthy population, we enrolled 364 healthy subjects, ages 18-80 years, to have a complete, nonimaging TCD examination. Subjects with known or suspected cerebrovascular disorders, systemic disorders with cerebrovascular effects, as well as those with known hypertension, diabetes, stroke, coronary artery disease, or myocardial infarction, were excluded. Self-reported ethnicity, handedness, BP, and BMI were recorded. A complete TCD examination was performed by a single experienced sonographer, using a single gate nonimaging TCD device, and a standardized protocol to interrogate up to 23 arterial segments. Individual Doppler spectra were saved for each segment, with velocity and pulsatility index (PI) values calculated using the instrument's automated waveform tracking function. Descriptive analysis was done to determine the mean

  11. ANALYSIS OF DATA ON DOSES OF EXTERNAL TERRIGENOUS IRRADIATION OF THE RUSSIAN FEDERATION POPULATION IN MUNICIPAL CONDITIONS

    Directory of Open Access Journals (Sweden)

    I. P. Stamat

    2015-01-01

    Full Text Available By this time in the Russian Federation there is collected a huge file of data describing the influence of all natural sources of ionizing radiation on population in municipal conditions. These data are collected and generalized in radiation hygiene passports of the Russian Federation for the last 16 years and in the reporting forms of federal statistical supervision No 4-DOZ “Data on doses of population irradiation due to the natural and manchanged radiation background” for a period of 14 years. These data are received by direct measurements of gamma radiation dose rate in the premises and in the open air on the territory of settlements. Measurements were made with the most different dosimeters; their technical and metrological parameters differ considerably. In this regard of certain interest is evaluation of this data reliability degree; that will help to find out the reasons of higher levels of the Russian Federation population external irradiation in comparison with average global dose values.In this article an attempt was made to evaluate reliability degree of data on the population external irradiation doses using the radiation hygiene passports of territories and reporting forms No 4-DOZ for the whole period of supervision. For this there was used the known dependence between the gamma radiation dose rate and natural radionuclides effective specific activity (AEFF in inhabitancy objects. For this purpose there were used the data on average AEFF values of building raw materials and of local manufacture materials, which are presented in radiation hygiene passports of territories. Definition of design value of gamma radiation dose rate in the buildings and in the open air according to AEFF measurement data in building raw materials and in local manufacture materials actually enables to get an independent evaluation of the population external irradiation doses. Comparison of two evaluations of the population external irradiation levels

  12. The Outskirts during the First Russian Revolution (1905–1907 years): the Separatist Moods among the Population of the Black Sea Province

    OpenAIRE

    Konstantin V. Taran; Andrei P. Mikhailov; Susanna D. Bagdasaryan

    2016-01-01

    The article discusses the separatist moods among the Georgian population of the Black sea province. The attention is paid to the attempts of the georgian social-democrats to separate the Sochi district from the Russian Empire in 1905–1907 years. Among the materials are the archival documents of central and regional archives, namely the state archive of the Russian Federation, state archive of the Krasnodar Krai, the documentation center of contemporary history of Krasnodar Krai, the archival ...

  13. Pinch Strengths in Healthy Iranian Children and Young Adult Population

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    Iman Dianat

    2015-03-01

    Full Text Available Background: Data on the physical strength capabilities are essential for design-ing safe and usable products and are useful in a wide range of clinical settings especially during treatment of disease affecting the function of the hand. The purpose of this study was to determine peak lateral pinch strength, key pinch strength, tip-to-tip pinch strength and three-jaw pinch strength exertions in a healthy Iranian children and young adult population.Methods: The study was conducted among 511 participants (242 males and 269 females aged 7-30 years. Measurements were carried out with both dominant and non-dominant hands in standard sitting posture using a B&L pinch gauge. Two repetitions of each strength measurement were recorded for each condition and the average value of the two trials was used in the subsequent analysis.Results: The results showed significant differences in the pinch strength data in terms of the age, gender and hand dominance. The lateral pinch strength, key pinch strength, tip-to-tip pinch strength and three-jaw pinch strength exertions by females were 68.4%, 68.8%, 78.8% and 81.8% of those exerted by males, respectively. Strength exertions with the non-dominant hand were 6.4%, 5.2%, 6.6% and 5.1% lower than strength exertions of the dominant hand for the lat-eral pinch strength, key pinch strength, tip-to-tip pinch strength and three-jaw pinch strength exertions, respectively.Conclusion: These findings can be used to fill the gaps in strength data for Iranian population.

  14. [Genetic variability and differentiation of three Russian populations of yellow potato cyst nematode Globodera rostochiensis as revealed by nuclear markers].

    Science.gov (United States)

    Khrisanfova, G G; Kharchevnikov, D A; Popov, I O; Zinov'eva, S V; Semenova, S K

    2008-05-01

    Genetic variability of yellow potato cyst nematode G. rostochiensis from three Russian populations (Karelia, Vladimir oblast, and Moscow oblast) was investigated using two types of nuclear markers. Using RAPD markers identified with the help of six random primers (P-29, OPA-10, OPT-14, OPA-11, OPB-11, and OPH-20), it was possible to distinguish Karelian population from the group consisting of the populations from two adjacent regions (Moscow oblast and Vladimir oblast). Based on the combined matrix, containing 294 RAPD fragments, dendrogram of genetic differences was constructed, and the indices of genetic divergence and partition (P, H, and G(st)), as well as the gene flow indices N(m) between the nematode samples examined, were calculated. The dendrogram structure, genetic diversity indices, and variations of genetic distances between single individuals in each population from Karelia and Central Russia pointed to genetic isolation and higher genetic diversity of the nematodes from Karelia. Based on polymorphism of rDNA first intergenic spacer ITS1, attribution of all populations examined to the species G. rostochiensis was proved. Small variations of the ITS1 sequence in different geographic populations of nematodes from different regions of the species world range did not allow isolation of separate groups within the species. Possible factors (including interregional transportations of seed potato) affecting nematode population structure in Russia are discussed.

  15. Population growth of Varroa destructor (Acari: Varroidae) in colonies of Russian and unselected honey bee (Hymenoptera: Apidae) stock as related to numbers of foragers with mites

    Science.gov (United States)

    Varroa mites are an external parasite of honey bees and a leading cause of colony losses worldwide. Varroa populations can be controlled with miticides, but mite resistant stocks such as the Russian honey bee (RHB) also are available. RHB and other mite resistant stock limit Varroa population growth...

  16. The ethnic gap in mobility: a comparison of Russian, Somali and Kurdish origin migrants and the general Finnish population

    Directory of Open Access Journals (Sweden)

    S. Rask

    2016-04-01

    Full Text Available Abstract Background Many ethnic minority populations have poorer health than the general population. However, there is limited knowledge on the possible ethnic gap in physical mobility. We aim to examine the prevalence of mobility limitations in working-age Russian, Somali and Kurdish origin migrants in comparison to the general population in Finland. We also determine whether the association between ethnic group and mobility limitation remains after taking into account socio-economic and health-related factors. Methods We used data from the Finnish Migrant Health and Wellbeing Study (Maamu and the Finnish Health 2011 Survey. The participants comprised 1880 persons aged 29–64 years. The age-adjusted prevalence of difficulties in various mobility tasks was calculated using predictive margins. Logistic regression analysis was used to examine the association between socio-economic, health- and migration-related factors and mobility limitation (self-reported difficulty in walking 500 m or stair climbing. The association between ethnic group and mobility limitation was calculated using logistic regression analysis. Results Mobility limitations were much more prevalent among Somali origin women (46 % and Kurdish origin men (32 % and women (57 % compared to men and women in the general Finnish population (5–12 %. In Russian origin men and women, the prevalence of mobility limitation (7–17 % was similar to the general Finnish population. Socio-economic and health-related factors, but not migration-related factors (time lived in Finland and language proficiency in Finnish or Swedish, were found to be associated with mobility limitation in the studied populations. Somali and Kurdish origin migrants were found to have increased odds for mobility limitation compared to the general Finnish population, even after adjusting for socio-economic and health-related factors (Somalis odds ratio [OR] 3.61; 95 % confidence interval [CI] 2.07–6.29, Kurds

  17. The incidence of acute rheumatic fever and chronic rheumatic heart disease in the Russian population (2011–2012

    Directory of Open Access Journals (Sweden)

    Rimma Mikhailovna Balabanova

    2014-03-01

    Full Text Available The problems of acute rheumatic fever (ARF and chronic rheumatic heart disease (CRHD are discussed. Carditis, polyarthritis, erythema annulare, subcutaneous nodules, and chorea minor are the main clinical manifestations of ARF caused by β-hemolytic streptococcus A. Cardiac failures emerge in 60–65% of patients after the first ARF episode. Repeated ARF attacks promote CRHD. The aim of the study is to evaluate the prevalence of rheumatic heart disease in different age groups in the regions of Russian Federation in 2011–2012. Materials and Methods. Analysis of the Ministry of Healthcare of the Russian Federation reports on population morbidity in 2011–2012 (Form N12.Results. The highest ARF prevalence was observed in 15–17-year-old teenagers, while the lowest, in adults over 18-year-old. The lowest CRHD figures were registered in juniors, while the highest ones, in adults. No ARF cases in 0–14-year-old children were registered in 31 entities of the Russian Federation; single cases, in 17 entities; no ARF cases in 15–17-year-old teenagers was registered in 37 entities, and 1–2 ARF cases were registered in 23 entities. Only in 10 entities, no ARF cases were registered in adults, and single cases were registered in 22 entities. Extremely unfavorable situations were found in the Chechen Republic (140 ARF cases in 0–14-year-old children and in the Dagestan Republic (140 cases. High morbidity among 15–17-year-old teenagers was registered in tje Kaliningrad region (83 cases and the Chechen Republic (100. ARF cases in adults were most frequent in St. Petersburg (124 cases, the Chechen Republic (154, and the Moscow region (161.The article lists the ARF and CRHD preventive measures.

  18. The incidence of acute rheumatic fever and chronic rheumatic heart disease in the Russian population (2011–2012

    Directory of Open Access Journals (Sweden)

    Rimma Mikhailovna Balabanova

    2014-01-01

    Full Text Available The problems of acute rheumatic fever (ARF and chronic rheumatic heart disease (CRHD are discussed. Carditis, polyarthritis, erythema annulare, subcutaneous nodules, and chorea minor are the main clinical manifestations of ARF caused by β-hemolytic streptococcus A. Cardiac failures emerge in 60–65% of patients after the first ARF episode. Repeated ARF attacks promote CRHD. The aim of the study is to evaluate the prevalence of rheumatic heart disease in different age groups in the regions of Russian Federation in 2011–2012. Materials and Methods. Analysis of the Ministry of Healthcare of the Russian Federation reports on population morbidity in 2011–2012 (Form N12.Results. The highest ARF prevalence was observed in 15–17-year-old teenagers, while the lowest, in adults over 18-year-old. The lowest CRHD figures were registered in juniors, while the highest ones, in adults. No ARF cases in 0–14-year-old children were registered in 31 entities of the Russian Federation; single cases, in 17 entities; no ARF cases in 15–17-year-old teenagers was registered in 37 entities, and 1–2 ARF cases were registered in 23 entities. Only in 10 entities, no ARF cases were registered in adults, and single cases were registered in 22 entities. Extremely unfavorable situations were found in the Chechen Republic (140 ARF cases in 0–14-year-old children and in the Dagestan Republic (140 cases. High morbidity among 15–17-year-old teenagers was registered in tje Kaliningrad region (83 cases and the Chechen Republic (100. ARF cases in adults were most frequent in St. Petersburg (124 cases, the Chechen Republic (154, and the Moscow region (161.The article lists the ARF and CRHD preventive measures.

  19. HYPERURICEMIA AND ITS CORRELATES IN THE RUSSIAN POPULATION (RESULTS OF ESSE-RF EPIDEMIOLOGICAL STUDY

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    S. A. Shalnova

    2014-01-01

    Full Text Available Aim. To study the prevalence of hyperuricemia in the Russian regions, depending on the climatic, geographical, socio-demographic characteristics and some cardiometabolic risk factors.Material and methods. Data from the ESSE-RF study from 10 regions of theRussian Federationare presented. All study participants were examined according to a uniform protocol. Measurements were standardized, biochemical tests were carried out in three Federal centers using the same methodology. The study was approved by independent Ethics committees, and all participants signed informed consent.Results. The prevalence of hyperuricemia was 16.8% (25.3% in men and 11.3% in women; p<0.0001. Hyperuricemia incidence increases with age, does not depend on education, significantly associates with place of residence, elevated blood pressure, obesity and abdominal obesity, alcohol consumption and diuretics taking. After adjustment for all factors included in the regression analysis, prevalence of hyperuricemia in the Ivanovo Region is 1.4 times higher than this in the reference region (Tyumen, while prevalence of hyperuricemia in the Samara Region and theRepublicofNorth Ossetia-Alaniais 30% and 40 % lower.Conclusion. Prevalence of hyperuricemia inRussiais defined; regions with the highest and lowest prevalence are identified. Associations of hyperuricemia with some social and demographic characteristics as well as cardiovascular risk factors are revealed.

  20. Safety analysis of a Russian phage cocktail: From MetaGenomic analysis to oral application in healthy human subjects

    Energy Technology Data Exchange (ETDEWEB)

    McCallin, Shawna, E-mail: semccallin@yahoo.com [Nestlé Research Centre, Nestec Ltd, Vers-chez-les-Blanc, CH-1000 Lausanne 26 (Switzerland); Alam Sarker, Shafiqul, E-mail: sasarker@icddrb.org [International Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b), 68 Shaheed Tajuddin Ahmed Sharani, Mohakhali, Dhaka 1212 (Bangladesh); Barretto, Caroline, E-mail: Caroline.Barretto@rdls.nestle.com [Nestlé Research Centre, Nestec Ltd, Vers-chez-les-Blanc, CH-1000 Lausanne 26 (Switzerland); Sultana, Shamima, E-mail: shamima@icddrb.org [International Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b), 68 Shaheed Tajuddin Ahmed Sharani, Mohakhali, Dhaka 1212 (Bangladesh); Berger, Bernard, E-mail: bernard.berger@rdls.nestle.com [Nestlé Research Centre, Nestec Ltd, Vers-chez-les-Blanc, CH-1000 Lausanne 26 (Switzerland); Huq, Sayeda, E-mail: sayeeda@mail.icddrb.org [International Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b), 68 Shaheed Tajuddin Ahmed Sharani, Mohakhali, Dhaka 1212 (Bangladesh); Krause, Lutz, E-mail: ltz.krause@gmail.com [Nestlé Research Centre, Nestec Ltd, Vers-chez-les-Blanc, CH-1000 Lausanne 26 (Switzerland); Bibiloni, Rodrigo, E-mail: Rodrigo.Bibiloni@agresearch.co.nz [Nestlé Research Centre, Nestec Ltd, Vers-chez-les-Blanc, CH-1000 Lausanne 26 (Switzerland); Schmitt, Bertrand, E-mail: bertrand.schmitt@rdls.nestle.com [Nestlé Research Centre, Nestec Ltd, Vers-chez-les-Blanc, CH-1000 Lausanne 26 (Switzerland); Reuteler, Gloria, E-mail: gloria.reuteler@rdls.nestle.com [Nestlé Research Centre, Nestec Ltd, Vers-chez-les-Blanc, CH-1000 Lausanne 26 (Switzerland); Brüssow, Harald, E-mail: harald.bruessow@rdls.nestle.com [Nestlé Research Centre, Nestec Ltd, Vers-chez-les-Blanc, CH-1000 Lausanne 26 (Switzerland)

    2013-09-01

    Phage therapy has a long tradition in Eastern Europe, where preparations are comprised of complex phage cocktails whose compositions have not been described. We investigated the composition of a phage cocktail from the Russian pharmaceutical company Microgen targeting Escherichia coli/Proteus infections. Electron microscopy identified six phage types, with numerically T7-like phages dominating over T4-like phages. A metagenomic approach using taxonomical classification, reference mapping and de novo assembly identified 18 distinct phage types, including 7 genera of Podoviridae, 2 established and 2 proposed genera of Myoviridae, and 2 genera of Siphoviridae. De novo assembly yielded 7 contigs greater than 30 kb, including a 147-kb Myovirus genome and a 42-kb genome of a potentially new phage. Bioinformatic analysis did not reveal undesired genes and a small human volunteer trial did not associate adverse effects with oral phage exposure. - Highlights: • We analyzed the composition of a commercial Russian phage cocktail. • The cocktail consists of at least 10 different phage genera. • No undesired genes were detected. • No adverse effects were seen upon oral application in a small human clinical trial.

  1. Safety analysis of a Russian phage cocktail: From MetaGenomic analysis to oral application in healthy human subjects

    International Nuclear Information System (INIS)

    McCallin, Shawna; Alam Sarker, Shafiqul; Barretto, Caroline; Sultana, Shamima; Berger, Bernard; Huq, Sayeda; Krause, Lutz; Bibiloni, Rodrigo; Schmitt, Bertrand; Reuteler, Gloria; Brüssow, Harald

    2013-01-01

    Phage therapy has a long tradition in Eastern Europe, where preparations are comprised of complex phage cocktails whose compositions have not been described. We investigated the composition of a phage cocktail from the Russian pharmaceutical company Microgen targeting Escherichia coli/Proteus infections. Electron microscopy identified six phage types, with numerically T7-like phages dominating over T4-like phages. A metagenomic approach using taxonomical classification, reference mapping and de novo assembly identified 18 distinct phage types, including 7 genera of Podoviridae, 2 established and 2 proposed genera of Myoviridae, and 2 genera of Siphoviridae. De novo assembly yielded 7 contigs greater than 30 kb, including a 147-kb Myovirus genome and a 42-kb genome of a potentially new phage. Bioinformatic analysis did not reveal undesired genes and a small human volunteer trial did not associate adverse effects with oral phage exposure. - Highlights: • We analyzed the composition of a commercial Russian phage cocktail. • The cocktail consists of at least 10 different phage genera. • No undesired genes were detected. • No adverse effects were seen upon oral application in a small human clinical trial

  2. Reference values of electrocardiogram repolarization variables in a healthy population

    DEFF Research Database (Denmark)

    Haarmark, Christian; Graff, Claus; Andersen, Mads P

    2010-01-01

    Reference values for T-wave morphology analysis and evaluation of the relationship with age, sex, and heart rate are lacking in the literature. In this study, we characterized T-wave morphology in a large sample of healthy individuals....

  3. Are the Russian-Speaking Populations in the “Near Abroad” a New Diaspora or Repatriates?

    Directory of Open Access Journals (Sweden)

    Irina Molodikova

    2002-04-01

    Full Text Available The article presents the traits of migration processes during the last ten years in some of the newly independent countries that emerged after the dissolution of the USSR. Research was conducted in former Soviet republics, selected on the basis of their different cultural, religious, economical and historical links to Russia (e.g. Kazakhstan, Latvia and the Ukraine. Six hundred potential migrants in these countries (former Soviet republics were asked why they applied in Russian consulates for resettlement to Russia. Another group of 400 respondents was selected from among actual migrants in two frontier regions of Russia (Siberia and the European regions. These persons arrived in Russia during the last ten years, i.e. in the period from the dissolution of the Soviet Union until the beginning of 2000. The main aim was to investigate decision-making processes pertaining to resettlement and adaptation. The research showed that the migration oriented behaviour of the Russian-speaking populations is dependent on cultural and historical links of the selected countries to Russia. The lowest level of emigration to Russia was from Slavic-speaking Ukraine, the highest from Muslim Kazakhstan. The answers both of the potential and of the actual migrants indicated a growing role of self-organised migration networks. The role of local authorities, responsible for providing assistance to migrants, has decreased during the time, both in the financial and informational spheres. A more important role has been played by informal and family relations. The role of NGOs in providing resettlement assistance has also risen. Nevertheless, the migration policy of Russia regarding its compatriots abroad may influence future migration flows. Yet this policy is not consecutive. At present, the process of creation of national states has almost been completed and the ethnic tensions are not the main reason for migration. Economical reasons are now the main motive for

  4. “Cultral” or “Kulturnichesky” Populism? (on the Meaning of Concepts in the History of Russian Populist Studies

    Directory of Open Access Journals (Sweden)

    Mokshin Gennadiy Nikolaevich

    2016-04-01

    Full Text Available The article is devoted to the origin and content of the concept of “cultural” and “kulturnichesky” populism in the Russian populist studies. Both terms appeared in the early twentieth century to refer to the right wing of the liberal populism. But they reflect different interpretations of the populist ideology: wide (of populism and narrow (of marxism. The term “cultural populism” (originated from “cultural work” reflects the desire of right-wing populists to create sociocultural prerequisites for changing the existing social order. The term “kulturnichesky populism” (from the German “kulturträger”, by the recognition of the Marxists themselves, was designed to discredit the populist program of social work in the countryside, allegedly aimed at reconciliation with reality. Most modern scholars following the tradition continue to use the concept of “kulturnichesky populism” and “cultural work”, sharing their biased interpretation. Not by chance in the scientific and educational literature, culturalpopulism direction is still associated with indifference with respect to political life and at the same time petty-bourgeois liberalism. According to the author, this approach not only distorts the ideas of populists-uplifters but also diminishes their contribution to the development of populist ideas of 1880-1890s. Therefore, for specialists in the history of legal populism it is recommended to use a more correct terms “cultural populism” and “cultural work”.

  5. Inequality of the Russian population in terms of quality of life and social preference order

    Directory of Open Access Journals (Sweden)

    Yu. P. Averin

    2014-01-01

    Full Text Available It is considered in this article a methodology way for research of people’s inequality in relation to quality life, and a mechanism influence it upon attitude towards contemporary social order in society and state, upon preference of the different communities in relation to it changes in dependence on condition of their quality life. It is showed the possibilities of the synergetic way to give an explanation this influence upon. Based on the results of sociological research of the objective and subjective variables is done the analysis of a inequality in relation to quality life among the residents of different types of Russian settlements - administrative and region towns, village community. It is exposed the preference dispositions of the residents in relation to democratic socialism, liberal democracy and “middle” order in comparison with them in dependence on condition of their quality life. It is done a conclusion about what a structure of the material and spiritual variables of quality life have an influence upon choice the residents the types of given order at present.

  6. HFE p.C282Y gene variant is associated with varicose veins in Russian population.

    Science.gov (United States)

    Sokolova, Ekaterina A; Shadrina, Alexandra S; Sevost'ianova, Kseniya S; Shevela, Andrey I; Soldatsky, Evgenii Yu; Seliverstov, Evgenii I; Demekhova, Marina Yu; Shonov, Oleg A; Ilyukhin, Evgenii A; Smetanina, Mariya A; Voronina, Elena N; Zolotukhin, Igor A; Filipenko, Maxim L

    2016-08-01

    Recently, the association of polymorphism rs1800562 (p.C282Y) in the hemochromatosis (HFE) gene with the increased risk of venous ulceration was shown. We hypothesized that HFE gene polymorphism might be involved not only in ulceration process, but also in susceptibility to primary varicose veins. We genotyped HFE p.C282Y (rs1800562) and p.H63D (rs1799945) variants in patients with primary varicose veins (n = 463) and in the control group (n = 754). In our study, p.282Y variant (rs1800562 A allele) was significantly associated with the risk of varicose veins (OR 1.79, 95 % CI = 1.11-2.89, P = 0.02). A borderline significant reverse association of p.63D variant (rs1799945 G allele) with venous leg ulcer development was revealed in Russians (OR 0.25, 95 % CI = 0.06-1.00, P = 0.05), but not in the meta-analysis (P = 0.56). We conclude that the HFE gene polymorphism can affect the risk of developing primary varicose veins.

  7. Arg25Pro polymorphism of transforming growth factor-beta1 and its role in the pathogenesis of essential hypertension in Russian population of the Central Chernozem Region.

    Science.gov (United States)

    Ivanov, V P; Solodilova, M A; Polonnikov, A V; Belugin, D A; Shestakov, A M; Ushachev, D V; Khoroshaya, I V; Katargina, L N; Kozhukhov, M A; Kolesnikova, O E

    2007-07-01

    We studied the relationship between Arg25Pro polymorphism of TGFbeta1 gene and predisposition to essential hypertension in the Russian population of Central Chernozem Region (n=402). An association was found between 25Pro allele and 25ArgPro genotype with low risk of essential hypertension in male individuals.

  8. Social-psychological well-being of rural population in the White Sea coastal area as a risk factor for the Russian Arctic policy

    Directory of Open Access Journals (Sweden)

    Andrey O. Podoplekin

    2016-10-01

    Full Text Available The article represents a generalized data from sociological survey of social-psychological well-being of the rural population of the coastal areas in Arkhangelsk region (included into the Russian Arctic zone held in 2015. The data shows a critical level of social pessimism, assurance of residents in continuation of negative social-economic dynamics, deficiency of motivation and readiness for active participation and inclusion into the development of territories. Such a status is based on a deep degradation of local industries, infrastructures and social sphere, which has been confirmed by statistic data. The revealed indicators explain high migration preparedness, especially in groups of working ages, proceeding, in the middle-term prospective, to the risk of depopulation and disintegration of social carcass in the coastal areas which, in their turn, possess a significant resource potential. At that, residential population on these areas considered as strategic factor from the perspective of Russian geopolitical interests in the Arctic. A positive trend may be provided through implementation of spatial approach to the social-economic development, which has been already applied in activities held by the Russian State Commission on the Arctic Development. With that there is obvious relevance of correction of the Russian legislation toward transformation of residential population into the beneficiary party of the macro-regional development, which may be provided by establishing of special regimes and preferences in spheres of natural resource use, tax assessment, entrepreneurship and crediting for all groups indigenous (resident population, including aboriginal people of the North.

  9. Distribution of external exposures in the Russian population after the Chernobyl accident

    International Nuclear Information System (INIS)

    Balonov, M.I.; Golikov, V.Yu.; Erkin, V.G.; Ponomarev, A.V.

    2000-01-01

    The data of the monitoring of external exposure in the population of the Chernobyl accident area in Russia during seven years are presented. The deterministic model has been developed for estimation of the average dose of external exposure for different groups of urban and rural populations. The model has been verified with the results of over 10 thousand measurements of individual doses in inhabitants by means of thermoluminescent dosimeters. The stochastic model is being developed by forming the dose of external exposure in the population of a contaminated area, which allows to predict the dose distribution in critical groups of a population for the purposes of radiation protection. (author)

  10. [[Length polymorphism of minisatellite repeat B2-VNTR of the bradykinin B2 receptor gene in healthy Russians and in patients with coronary heart disease].

    Science.gov (United States)

    Suchkova, I O; Pavlinova, L I; Larionova, E E; Alenina, N V; Solov'ev, K V; Baranova, T V; Belotserkovskaia, E V; Sasina, L K; Bader, M; Denisenko, A D; Mustafina, O E; Khusnutdinova, E K; Patkin, E L

    2014-01-01

    Bradykinin B2 receptor is involved in many processes, including the regulation of blood pressure and smooth muscle contraction, vasodilation, inflammation, edema, cell proliferation, pain. It is suggested that this receptor may be one of the factors that have cardioprotective and infarct-limiting effects. It is assumed that certain genetic variants in both coding and non-coding regions ofBDKRB2 gene may influence its expression. In the 3'-untranslated region of BDKRB2 exon 3 the minisatellite repeat B2-VNTR is located. B2-VNTR has previously been shown to affect the BDKRB2 mRNA stability. Therefore, it is important to perform the molecular genetic analysis of this minisatellite in patients with different forms of coronary heart disease in order to reveal possible associations between specific B2-VNTR alleles and certain clinical forms of coronary heart disease. In the present study, a comparative analysis of the allele and genotype frequencies of B2-VNTR was carried out in groups of healthy individuals and patients with two clinical forms of coronary heart disease (angina pectoris and myocardial infarction), ethnically Russian. The results of the B2-VNTR length polymorphism analysis indicate that this tandem repeat may be attributed to a class of low polymorphic and non-hypervariable minisatellite. In all analyzed groups we revealed three B2-VNTR alleles, consisting of 43, 38 and 33 repeat units. Alleles of 43 and 33 repeats were major in all investigated groups. No statistically significant differences were found in the B2-VNTR allele and genotype frequencies between men and women in control group, and also between healthy men and men with angina pectoris and myocardial infarction. Thus, B2-VNTR length polymorphism was not associated with these clinical forms of coronary heart disease in Russian men. However, we do not exclude the possibility of association between the B2-VNTR short alleles (38 and 33 repeats) and cardioprotective effects of bradykinin B2 receptor

  11. Russian wheat aphid, Diuraphis noxia in the Czech Republic – cause of the significant population decrease

    Czech Academy of Sciences Publication Activity Database

    Havelka, Jan; Žurovcová, Martina; Rychlý, S.; Starý, Petr

    2014-01-01

    Roč. 138, č. 4 (2014), s. 273-280 ISSN 0931-2048 R&D Projects: GA ČR GA522/09/1940 Institutional support: RVO:60077344 Keywords : alien aphid species * anholocyclic populations * aphids overwintering mortality Subject RIV: EH - Ecology, Behaviour Impact factor: 1.650, year: 2014 http://onlinelibrary.wiley.com/doi/10.1111/jen.12068/pdf

  12. Correlation Between Personality Traits and Testosterone Concentrations in Healthy Population.

    Science.gov (United States)

    Tajima-Pozo, Kazuhiro; Bayón, Camila; Díaz-Marsá, Marina; Carrasco, Jose Luis

    2015-01-01

    High plasma testosterone levels have been associated with aggression, sexual behaviour and social status. The aim of this paper was to study the correlation between basal plasma testosterone levels and personality variables in healthy participants. Fifty-four participants were randomly enrolled into this study. Basal plasma testosterone levels were measured between 8:30 am and 10 am. After 24 hours of blood drawing, each subject completed personality questionnaires. Positive correlation between basal plasma testosterone levels and anti-social personality traits in both genders was observed (r = 0.336 and P traits (r = 0. 376, P trait (r = 0. 544, P trait (r = 0. 485, P trait (r = 0.632, P traits, substance abuse and hypomania. Women with higher basal testosterone levels showed higher scores on personality self-direction traits.

  13. Body water distribution and risk of cardiovascular morbidity and mortality in a healthy population

    DEFF Research Database (Denmark)

    Knudsen, Nikoline Nygård; Kjærulff, Thora Majlund; Ward, Leigh Cordwin

    2014-01-01

    Early alterations in the cardiovascular structure and function may change normal body water distribution. The resulting fluid shifts may thus serve as an early marker for cardiovascular disease. However, studies examining this in healthy populations are absent.......Early alterations in the cardiovascular structure and function may change normal body water distribution. The resulting fluid shifts may thus serve as an early marker for cardiovascular disease. However, studies examining this in healthy populations are absent....

  14. Fostering Healthy Lifestyles in the African American Population

    Science.gov (United States)

    Murimi, Mary; Chrisman, Matthew S.; McAllister, Tiffany; McDonald, Olevia D.

    2015-01-01

    Approximately 8.3% of the U.S. population (25.8 million people) is affected by type 2 diabetes. The burden of diabetes is disproportionately greater in the African American community. Compared with non-Hispanic Caucasian adults, the risk of diagnosed type 2 diabetes was 77% higher among non-Hispanic Blacks, who are 27% more likely to die of…

  15. Mineral compactness of vertebrae in Russian population in health according to quantitative computer-aided tomography

    International Nuclear Information System (INIS)

    Vlasova, I.S.; Sorokin, A.D.; Gorbatov, M.M.; Vozhagov, V.V.; Ternovoj, S.K.

    1998-01-01

    To create a reference database for residents of Central Russia and estimate the rate of calcium loss by bone tissue the mineral compactness of vertebral trabecular substance was studied by quantitative computer-aided tomography in 1061 subjects (610 females and 451 males aged 12-89 and 7-91 years, respectively) without somatic diseases and taking no drugs affecting osseous metabolism. Comparison of mineral bone density (MCB) regression curves in residents of Central Russia and of the values provided by producer firms shows differences in calcium content of vertebral trabecular substance, which can be due to specific ethnic features of different populations, lifestyle, and nutrition habits [ru

  16. Population Growth of Varroa destructor (Acari: Varroidae) in Colonies of Russian and Unselected Honey Bee (Hymenoptera: Apidae) Stocks as Related to Numbers of Foragers With Mites.

    Science.gov (United States)

    DeGrandi-Hoffman, Gloria; Ahumada, Fabiana; Danka, Robert; Chambers, Mona; DeJong, Emily Watkins; Hidalgo, Geoff

    2017-06-01

    Varroa (Varroa destructor Anderson and Trueman) is an external parasite of honey bees (Apis mellifera L.) and a leading cause of colony losses worldwide. Varroa populations can be controlled with miticides, but mite-resistant stocks such as the Russian honey bee (RHB) also are available. Russian honey bee and other mite-resistant stocks limit Varroa population growth by affecting factors that contribute to mite reproduction. However, mite population growth is not entirely due to reproduction. Numbers of foragers with mites (FWM) entering and leaving hives also affect the growth of mite populations. If FWM significantly contribute to Varroa population growth, mite numbers in RHB colonies might not differ from unselected lines (USL). Foragers with mites were monitored at the entrances of RHB and USL hives from August to November, 2015, at two apiary sites. At site 1, RHB colonies had fewer FWM than USL and smaller phoretic mite populations. Russian honey bee also had fewer infested brood cells and lower percentages with Varroa offspring than USL. At site 2, FWM did not differ between RHB and USL, and phoretic mite populations were not significantly different. At both sites, there were sharp increases in phoretic mite populations from September to November that corresponded with increasing numbers of FWM. Under conditions where FWM populations are similar between RHB and USL, attributes that contribute to mite resistance in RHB may not keep Varroa population levels below that of USL. Published by Oxford University Press on behalf of Entomological Society of America 2017. This work is written by US Government employees and is in the public domain in the US.

  17. ASSOCIATION OF RISK FACTORS FOR NON-COMMUNICABLE DISEASES WITH HEALTH CARE RESOURCES UTILIZATION AND TEMPORARY DISABILITY ACCORDING TO DATA OF POPULATION STUDY IN RUSSIAN FEDERATION

    OpenAIRE

    E. I. Suvorova; S. A. Shalnova; A. V. Kontsevaya; A. D. Deev; A. V. Kapustina; Yu. A. Balanova

    2018-01-01

    Aim. To analyze the associations of health care system resources utilization and temporary disability (TD) with the main risk factors (RF) for cardiovascular diseases (CVD) in working age population based on ESSE-RF study data.Material and methods. The analysis was based on ESSE-RF study data (13 regions of the Russian Federation). Standard epidemiological survey methods and evaluation criteria were used. The analysis included results of a survey of the ESSE-RF study participants about the ut...

  18. Pre-pregnancy body mass index and inter-pregnancy weight change among women of Russian, Somali and Kurdish origin and the general Finnish population.

    Science.gov (United States)

    Bastola, Kalpana; Koponen, Päivikki; Härkänen, Tommi; Gissler, Mika; Kinnunen, Tarja I

    2017-05-01

    We studied the differences in the mean pre-pregnancy body mass index (BMI) and mean inter-pregnancy weight change in women of Russian, Somali and Kurdish origin and women in the general Finnish population. The population-based samples were from the Migrant Health and Wellbeing Study and the Health 2011 Survey conducted in six cities in Finland in 2010-2012. This study included women with at least one birth in Finland. Data on their previous pregnancies in Finland were obtained from the National Medical Birth Register for 318 Russian, 584 Somali and 373 Kurdish origin women and for 243 women in the general Finnish population (reference group). Data on pre-pregnancy weight and height were self-reported in early pregnancy. Linear logistic regression was the main method of analysis. The unadjusted mean pre-pregnancy BMI was higher in Somali (27.0 kg/m 2 , p<0.001) and Kurdish (25.8 kg/m 2 , p<0.001) women, but lower in Russian (22.2 kg/m 2 , p<0.001) women than in the reference group (24.1 kg/m 2 ). The adjusted coefficients for the difference in the mean pre-pregnancy BMI were -1.93 (95% CI -2.77 to -1.09) for Russian, 1.82 (95% CI 0.89-2.75) for Somali and 1.30 (95% CI 0.43-2.17) for Kurdish women compared with the reference group. Among women with at least two births, no statistically significant difference was observed in the mean inter-pregnancy weight change between the migrant groups and the reference group. Somali and Kurdish women had higher mean pre-pregnancy BMIs than women in the general Finnish population and may need special support and health promotion strategies for weight management.

  19. Characteristics of healthy population among the migrants to the North.

    Science.gov (United States)

    Leutin, V P

    2001-11-01

    The goal of the study was to elucidate psychophysiological characteristics of subjects who can adapt effectively to Arctic and Subarctic conditions. Plasma cortisol and insulin levels, blood pressure as well as functional sensori-motor asymmetry have been examined in the groups of North Selkups and transit workers from the Subarctic regions. The highest level of plasma cortisol was observed in the Selkups with the predominance of the right indices of sensorimotor asymmetry, whereas the lowest cortisol concentrations have been found in the left-handed groups. The level of insulin appeared to be lower in all examined groups of the Selkups. No changes in the blood pressure were found among the northern populations. The maximum incidence of arterial hypertension was revealed among shift workers with the predominance of the right profile of functional asymmetry. The indices of functional asymmetry, giving important information about adaptive abilities of different populations to severe climato-geographical conditions, can be a useful prognostic factor for the professional selection of workers in the North regions.

  20. From population connectivity to the art of striping Russian dolls: the lessons from Pocillopora corals.

    Science.gov (United States)

    Gélin, Pauline; Fauvelot, Cécile; Bigot, Lionel; Baly, Joseph; Magalon, Hélène

    2018-01-01

    Here, we examined the genetic variability in the coral genus Pocillopora , in particular within the Primary Species Hypothesis PSH09, identified by Gélin, Postaire, Fauvelot and Magalon (2017) using species delimitation methods [also named Pocillopora eydouxi/meandrina complex sensu , Schmidt-Roach, Miller, Lundgren, & Andreakis (2014)] and which was found to split into three secondary species hypotheses (SSH09a, SSH09b, and SSH09c) according to assignment tests using multi-locus genotypes (13 microsatellites). From a large sampling (2,507 colonies) achieved in three marine provinces [Western Indian Ocean (WIO), Tropical Southwestern Pacific (TSP), and Southeast Polynesia (SEP)], genetic structuring analysis conducted with two clustering analyses (structure and DAPC) using 13 microsatellites revealed that SSH09a was restricted to the WIO while SSH09b and SSH09c were almost exclusively in the TSP and SEP. More surprisingly, each SSH split into two to three genetically differentiated clusters, found in sympatry at the reef scale, leading to a pattern of nested hierarchical levels (PSH > SSH > cluster), each level hiding highly differentiated genetic groups. Thus, rather than structured populations within a single species, these three SSHs, and even the eight clusters, likely represent distinct genetic lineages engaged in a speciation process or real species. The issue is now to understand which hierarchical level (SSH, cluster, or even below) corresponds to the species one. Several hypotheses are discussed on the processes leading to this pattern of mixed clusters in sympatry, evoking formation of reproductive barriers, either by allopatric speciation or habitat selection.

  1. Sanitary study of the population living in the Chernobyl region

    International Nuclear Information System (INIS)

    Mettler, F.A. Jr.; Briggs, J.E.

    1991-01-01

    The populations of Ukraine, Belarus and Russian Federation affected by Chernobyl accident are anxious about the radiation effects on their healthy. The International Chernobyl Project has, in a great part, looked for the pathology increase and to assess its incidence on their healthy. This study does not prove that the Chernobyl accident would have important effects on population healthy of contaminated areas

  2. Genetic predisposition to alcoholism, schizophrenia and Alzheimer’s disease with psychodiagnostic characteristics in russian population

    Directory of Open Access Journals (Sweden)

    A. V. Marusin

    2016-01-01

    Full Text Available The purpose of this paper is to identify genetic factors connected with personal features using the panel of 12 polymorphic markers associated with the risk of developing dementia in patients with Alzheimer’s disease, schizophrenia and alcoholism.Materials and methods. The correlation among quantitative traits of personality, temperament and character determined with Cattell’s (the Sixteen personality factor questionnaire (16PF, Leonhard-Schmieschek’s, Spielberger-Khanin’s, and Eysenck’s (IQ tests were analyzed with polymorphic variants of 12 genes involved in the development of severe mental disorders such as alcoholism, schizophrenia and Alzheimer’s disease. DNA samples of 150 students were genotyped using PCR-RPLF method. The data were processed by nonparametric statistical methods.Results. Interallelic nonrandom associations in paired combinations of GABRA2-PICALM, PICALMADCY3, CLU-CBX7 and CLU-ADCY3 polymorphisms were detected. This may indicate the adaptive selection influencing the maintenance of behavioral homeostasis in population. A number of statistically significant associations of genetic variation were found: CLU with perfectionism(Q3 of 16PF and the exaltation of the Leonhard’s tests, PICALM with tension (Q4 of 16PF and the imbalance of Leonhard’s tests, DISC1 with vigilance(L of 16PF, and exaltation, cyclothymia of Leonhard’s tests, ZNF804A with imbalance by Leonhard’s test, SLC6A4 with reasoning(B of 16PF test, ADCY3 with self-reliance(Q2 and extraversion(F2 of 16PF test, MIR9-2 emotional stability(C, liveliness(F, social boldness(H, extraversion(F2 of 16PF, and dysthymia, hyperthymia of Leonhard’s tests, with the personal anxiety of Spielberger-Khanin’s test, CBX7 with vigilance(L, warmth(A of 16PF test, SLC6A3 with IQ.Conclusion. These findings support the idea of overlapping genetic component in common mental and neurological disorders and variability of human cognitive and personality traits.

  3. JP-3 gene polymorphism in a healthy population of Serbia and ...

    Indian Academy of Sciences (India)

    Unknown

    sions are the cause of Huntington disease like-2 (HDL-2) phenotype. CTG repeats in ... Analyses of CTG repeat polymorphism of JP-3 gene in various healthy populations could help in estimating ... of a recently described membrane protein family exclu- .... low frequency of larger alleles in German population based on very ...

  4. Ethnic Russian Minority in Estonia

    Directory of Open Access Journals (Sweden)

    Włodarska-Frykowska Agata

    2016-12-01

    Full Text Available The article examines the position of Russians in Estonia and their relation with ethnic Estonians. The author analyzes models of the society integration introduced by Tallinn after 1991. The results raise questions regarding language education in Estonia, the proficiency level of Estonian is getting widely known by Russians, but on the other hand, there is still a significant part of the population that cannot communicate in Estonian. Those who have a good command of Estonian tend to be better integrated and to coexist with both Estonians and Russians. Russians living in Estonia are supposed to be equally involved in social and political life of the state. The potential of all residents has to be effectively and considerably used, especially when the number of population is decreasing. The position of Russians in Estonia is a major domestic and bilateral issue in the relations with the Russian Federation.

  5. [The general methodological approaches identifying strategic positions in developing healthy lifestyle of population].

    Science.gov (United States)

    Dorofeev, S B; Babenko, A I

    2017-01-01

    The article deals with analysis of national and international publications concerning methodological aspects of elaborating systematic approach to healthy life-style of population. This scope of inquiry plays a key role in development of human capital. The costs related to healthy life-style are to be considered as personal investment into future income due to physical incrementation of human capital. The definitions of healthy life-style, its categories and supportive factors are to be considered in the process of development of strategies and programs of healthy lifestyle. The implementation of particular strategies entails application of comprehensive information and educational programs meant for various categories of population. Therefore, different motivation techniques are to be considered for children, adolescents, able-bodied population, the elderly. This approach is to be resulted in establishing particular responsibility for national government, territorial administrations, health care administrations, employers and population itself. The necessity of complex legislative measures is emphasized. The recent social hygienic studies were focused mostly on particular aspects of development of healthy life-style of population. Hence, the demand for long term exploration of development of organizational and functional models implementing medical preventive measures on the basis of comprehensive information analysis using statistical, sociological and professional expertise.

  6. The Outskirts during the First Russian Revolution (1905–1907 years: the Separatist Moods among the Population of the Black Sea Province

    Directory of Open Access Journals (Sweden)

    Konstantin V. Taran

    2016-06-01

    Full Text Available The article discusses the separatist moods among the Georgian population of the Black sea province. The attention is paid to the attempts of the georgian social-democrats to separate the Sochi district from the Russian Empire in 1905–1907 years. Among the materials are the archival documents of central and regional archives, namely the state archive of the Russian Federation, state archive of the Krasnodar Krai, the documentation center of contemporary history of Krasnodar Krai, the archival departments of Sochi administration and the historical museum of Sochi. The methodological basis of work based on the principles of objectivity and historicism, suggesting an unbiased approach to the analysis of the studied problems, as well as the critical attitude towards the sources. In conclusion, the authors stated that the social democrats used various methods of dealing with the existing regime, such as the destabilization of public-political situation, expressed in discrediting the Russian administration, provoking ethnic conflicts, the elimination of competitors in wage employment in the trade, physical violence against undesirable persons, the bullying of political opponents, taking money from the haves of the population, and collectively, the escalation of social tensions that eventually led to an armed clash with the authorities.

  7. Comparison of CYP2C9, CYP2C19, CYP2D6, ABCB1, and SLCO1B1 gene-polymorphism frequency in Russian and Nanai populations

    Directory of Open Access Journals (Sweden)

    Sychev DA

    2017-03-01

    Full Text Available Dmitrij Alekseevitch Sychev,1 Grigorij Nikolaevich Shuev,1 Salavat Shejhovich Suleymanov,2 Kristina Anatol’evna Ryzhikova,3 Karin Badavievich Mirzaev,3 Elena Anatol’evna Grishina,3 Natalia Evgenievna Snalina,3 Zhannet Alimovna Sozaeva,3 Anton Mikhailovich Grabuzdov,4 Irina Andreevna Matsneva4 1Department of Internal Medicine and Clinical Pharmacology, Russian Medical Academy of Continuing Professional Education, Ministry of Healthcare, Moscow, 2Saiko Russian–Japanese Medical Center, Khabarovsk, 3Research Centre, Russian Medical Academy of Continuous Professional Education, Ministry of Healthcare, 4Department of General Medicine, Sechenov First Moscow State Medical University, Moscow, Russian Federation Background: The efficiency and safety of drug therapy depends on the peculiarities of functioning of the P450 cytochrome group and transporting proteins. There are significant differences for single-nucleotide polymorphism (SNP frequency. Materials and methods: We studied the peculiarities of P450 cytochrome polymorphisms, SLCO1B1 transporting protein, and P-glycoprotein carriage in healthy volunteers in the Nanai ethnic group living in Russia, and compared them to the carriage of SNPs in the Russian population according to literature data. Results: After performing the real-time polymerase chain reactions on the samples from 70 healthy volunteers from the Nanai group, for the CYP2C9*2C430T polymorphism we determined 70 CC-genotype carriers. As for the CYP2C9*3A1075C polymorphism, we found 62 AA-genotype carriers and eight AC-genotype carriers. For the CYP2C19*2G681A polymorphism, we determined 39 GG-genotype carriers and 28 GA-genotype carriers, for the CYP2C19*3G636A polymorphism 58 GG-genotype carriers and 12 GA-genotype carriers, and for the CYP2C19*17C806T polymorphism 67 CC-genotype carriers and three CT-genotype carriers. For the CYP2D6*4G1846A polymorphism, the GG genotype had 68 carriers, and the GA genotype two carriers. For the

  8. Cognitive-enhancing drugs in the healthy population: Fundamental drawbacks and researcher roles

    Directory of Open Access Journals (Sweden)

    Tsee Leng Choy

    2015-12-01

    Full Text Available The use of pharmacological cognitive enhancers (PCEs in the healthy population is a controversial topic with numerous and expansive repercussions. By outlining common proponent arguments on the current PCE state of affairs, the definition of normality, and the complex regulation of PCEs, this article addresses why the mainstream use of PCEs in the healthy population is still disadvantageous overall. In this respect, the influence and roles of researchers to the society are emphasized in bringing the focus back to the fundamental issues, which is crucial in deciphering its controversy and avoiding costly societal, research credibility and ethical implications.

  9. Monitoring Bird Populations in Relation to Fuel Loads and Fuel Treatments in Riparian Woodlands with Tamarisk and Russian Olive Understories

    Science.gov (United States)

    Deborah M. Finch; June Galloway; David Hawksworth

    2006-01-01

    Over the past decade, wild fire events in riparian bosque (forested) areas along the Middle Rio Grande between Elephant Butte and Albuquerque have increased dramatically owing to flood suppression and accumulation of dead wood and exotic Tamarisk and Russian olive. This problem culminated in a large wild fire in July 1993 that resulted in the evacuation of hundreds of...

  10. Fish consumption, not fatty acid status, is related to quality of life in a healthy population

    NARCIS (Netherlands)

    Schiepers, Olga; De Groot, Renate; Jolles, Jelle; Van Boxtel, Martin

    2010-01-01

    Schiepers, O. J., De Groot, R. H. M., Jolles, J., & Van Boxtel, M. P. J. (2010). Fish consumption, not fatty acid status, is related to quality of life in a healthy population. Prostaglandins Leukot Essent Fatty Acids, 83(1), 31-35.

  11. PREVALENCE OF MARKERS OF VIRAL HEPATITIS B AND D FROM HEALTHY POPULATION IN REPUBLIC TYVA

    Directory of Open Access Journals (Sweden)

    T. V. Kozhanova

    2014-01-01

    Full Text Available Aim: to estimate prevalence of markers, genetic diversity, risk factors of HBV and HDV infections in all age groups among healthy population in Republic Tyva. Serum samples obtained from healthy population in Republic Tyva (N = 1086 were tested (aged from birth to older 60 years. The markers of HBV and HDV infections were determined by enzyme immunoassay and PCR. HBsAg was detected in 7,7% (84/1086, anti-HBc — in 47,8% (519/1086 and HBeAg — in 0,3% (3/1086 cases. Prevalence of HBsAg in children under 9 years was 1,3%, no positive results of anti-HDV were determined among children aged up to 9 year. Prevalence of anti-HDV among HBsAg-positive individuals of healthy population was 32,1% (27/84. HBV DNA was detected in 2,9% (31/1086 cases; HDV RNA — in 32,1% (14/84 HBsAg-positive individuals. The obtained data showed high prevalence of HBV ang HDV infections among healthy population of Republic Tyva. Thus, it is necessary to extend screening program in this region to improve viral hepatitis surveillance and diagnostics. The sharp decline in the prevalence of these infections in children up to 9 years in the surveyed endemic region is an evidence of effective protection against HBV and HDV with vaccination against hepatitis B. 

  12. Joint U.S./Russian studies of population exposures resulting from nuclear production activities in the southern Urals.

    Science.gov (United States)

    Napier, Bruce A

    2014-02-01

    of cohorts with their chronic, low dose-rate radiation exposure. The 26,000 workers at Mayak were highly exposed to external gamma and inhaled plutonium. A cohort of individuals raised as children in Ozersk is under evaluation for their exposures to radioiodine. The Techa River Cohort consists of over 30,000 people who were born before the start of exposure in 1949 and lived along the Techa River. The Techa River Offspring Cohort consists of ~21,000 persons born to one or more exposed parents of this group, many who also lived along the contaminated river. The EURT Cohort consists of ~18,000 people who were evacuated from the EURT soon after the 1957 explosion and another 8,000 who remained. These groups together are the focus of dose reconstruction and epidemiological studies funded by the United States, Russia, and the European Union to address the question, "Are doses delivered at low dose rates as effective in producing health effects as the same doses delivered at high dose rates?"Introduction of Joint U.S. and Russian Studies of Population Exposures (Video 2:13, http://links.lww.com/HP/A28).

  13. Comparative morphometry of facial surface models obtained from a stereo vision system in a healthy population

    Science.gov (United States)

    López, Leticia; Gastélum, Alfonso; Chan, Yuk Hin; Delmas, Patrice; Escorcia, Lilia; Márquez, Jorge

    2014-11-01

    Our goal is to obtain three-dimensional measurements of craniofacial morphology in a healthy population, using standard landmarks established by a physical-anthropology specialist and picked from computer reconstructions of the face of each subject. To do this, we designed a multi-stereo vision system that will be used to create a data base of human faces surfaces from a healthy population, for eventual applications in medicine, forensic sciences and anthropology. The acquisition process consists of obtaining the depth map information from three points of views, each depth map is obtained from a calibrated pair of cameras. The depth maps are used to build a complete, frontal, triangular-surface representation of the subject face. The triangular surface is used to locate the landmarks and the measurements are analyzed with a MATLAB script. The classification of the subjects was done with the aid of a specialist anthropologist that defines specific subject indices, according to the lengths, areas, ratios, etc., of the different structures and the relationships among facial features. We studied a healthy population and the indices from this population will be used to obtain representative averages that later help with the study and classification of possible pathologies.

  14. Defining normal liver stiffness range in a normal healthy Chinese population without liver disease.

    Directory of Open Access Journals (Sweden)

    James Fung

    Full Text Available BACKGROUND: For patients with chronic liver disease, different optimal liver stiffness cut-off values correspond to different stages of fibrosis, which are specific for the underlying liver disease and population. AIMS: To establish the normal ranges of liver stiffness in the healthy Chinese population without underlying liver disease. METHODS: This is a prospective cross sectional study of 2,528 healthy volunteers recruited from the general population and the Red Cross Transfusion Center in Hong Kong. All participants underwent a comprehensive questionnaire survey, measurement of weight, height, and blood pressure. Fasting liver function tests, glucose and cholesterol was performed. Abdominal ultrasound and transient elastography were performed on all participants. RESULTS: Of the 2,528 subjects, 1,998 were excluded with either abnormal liver parenchyma on ultrasound, chronic medical condition, abnormal blood tests including liver enzymes, fasting glucose, fasting cholesterol, high body mass index, high blood pressure, or invalid liver stiffness scan. The reference range for the 530 subjects without known liver disease was 2.3 to 5.9 kPa (mean 4.1, SD 0.89. The median liver stiffness was higher in males compared with females (4.3 vs 4.0 kPa respectively, p55 years (p=0.001. CONCLUSIONS: The healthy reference range for liver stiffness in the Chinese population is 2.3 to 5.9 kPa. Female gender and older age group was associated with a lower median liver stiffness.

  15. New Russian law

    International Nuclear Information System (INIS)

    Anon.

    1996-01-01

    The information about the Russian Federation law dealing with population radiation safety signed by the President in January 1996 is given. The law is based on a new strategy of radiation protection including the mean efficient dose from all ionizing radiation sources as the main factor for evaluation of the safe level for the population. The norms stated in the law will become valid from January 1, 2000

  16. Small Demodex populations colonize most parts of the skin of healthy dogs.

    Science.gov (United States)

    Ravera, Iván; Altet, Laura; Francino, Olga; Sánchez, Armand; Roldán, Wendy; Villanueva, Sergio; Bardagí, Mar; Ferrer, Lluís

    2013-02-01

    It is unproven that all dogs harbour Demodex mites in their skin. In fact, several microscopic studies have failed to demonstrate mites in healthy dogs. Demodex canis is a normal inhabitant of the skin of most, if not all, dogs. This hypothesis was tested using a sensitive real-time PCR to detect Demodex DNA in the skin of dogs. One hundred dogs living in a humane society shelter, 20 privately owned and healthy dogs and eight dogs receiving immunosuppressive or antineoplastic therapy. Hair samples (250-300 hairs with their hair bulbs) were taken from five or 20 skin locations. A real-time PCR that amplifies a 166 bp sequence of the D. canis chitin synthase gene was used. The percentage of positive dogs increased with the number of sampling points. When a large canine population was sampled at five cutaneous locations, 18% of dogs were positive for Demodex DNA. When 20 skin locations were sampled, all dogs tested positive for mite DNA. Our study indicates that Demodex colonization of the skin is present in all dogs, independent of age, sex, breed or coat. Nevertheless, the population of mites in a healthy dog appears to be small. Demodex DNA was amplified from all 20 cutaneous points investigated, without statistically significant differences. Using a real-time PCR technique, Demodex mites, albeit in very low numbers, were found to be normal inhabitants of haired areas of the skin of healthy dogs. © 2013 The Authors. Veterinary Dermatology © 2013 ESVD and ACVD.

  17. ACCIDENT AT «FUKUSHIMA-»I NPP: FIRST RESULTS OF EMERGENCY RESPONSE REPORT 2: ACTIVITIES OF THE ROSPOTREBNADZOR AUTHORITIES FOR THE RADIATION PROTECTION OF THE RUSSIAN FEDERATION POPULATION ON THE EARLY STAGE OF ACCIDENT

    Directory of Open Access Journals (Sweden)

    G. G. Onischenko

    2011-01-01

    Full Text Available Basic measures of the Rospotrebnadzor emergency response during the early stage of the «Fukushima-I» NPP radiation accident are being analyzed in the article. Radiation monitoring of the environmental objects of the territories of the Russian Federation Far East Federal District, radiation control of arriving from Japan vehicles, freights and passengers as well as imported from Japan food products were promptly organized. This allowed to get reliable evaluations of the levels of radioactive contamination at the Russian Federation territory and population exposure doses due to the «Fukushima-I» NPP accident, timely exclude the possibility of import to the Russian territory for the freights, vehicles, food products having contamination exceeding established in the Russian Federation standards.

  18. Healthy Eating Habits among the Population of Serbia: Gender and Age Differences

    OpenAIRE

    Jovi?i?, Ana ?.

    2015-01-01

    ABSTRACT The purpose of the study is to examine healthy eating habits of the population of Serbia through three dimensions: knowledge, problems, and feelings as well as to determine whether there are any differences between genders and among different age-groups. The research instrument was an Eating Habits Questionnaire (EHQ) which consisted of 35 items. There were 382 respondents involved in the study. The reliability and factor structure of the questionnaire were verified by using factor a...

  19. Between the Prohibition and Indulgence: Casual Religious Culture of the Orthodox Population Russian north in the Second Half of the XIX – early XX century

    Directory of Open Access Journals (Sweden)

    Pavel V. Fedorov

    2015-12-01

    Full Text Available In article proposes a new approach to the study of everyday religious culture of the Orthodox population. On the basis of the reconstruction of the demographic data on the primary sources for the Register of 1863-1917 of province Cola, revealed the degree of compliance with the orthodox traditions: on the naming, marriage and sexual abstinence during the Great and Advent, the birth of children outside marriage, of re-marriage. The author comes to the conclusion that social modernization has little effect on the religious culture of the local population of the Russian North. The revolution of 1917 brought in a small town outside of atheism as an extraneous ideology.

  20. Serum 25-hydroxyvitamin D in a West African population of tuberculosis patients and unmatched healthy controls

    DEFF Research Database (Denmark)

    Wejse, Christian; Olesen, Rikke; Rabna, Paulo

    2007-01-01

    BACKGROUND: Little is known regarding vitamin D deficiency (VDD) in African populations and in tuberculosis (TB) patients. VDD has been shown to be associated with TB. OBJECTIVE: We aimed to compare the degree of vitamin D insufficiency (VDI) and VDD in TB patients and healthy adult controls...... in a West African population. DESIGN: An unmatched case-control study was performed at a Demographic Surveillance Site in Guinea-Bissau. Serum 25-hydroxyvitamin D(3) [25(OH)D(3)] concentrations were measured in 362 TB patients and in 494 controls. RESULTS: Hypovitaminosis D [25(OH)D(3) Udgivelsesdato: 2007...

  1. [Effects and the associated factors of the 2016 China Motivational Healthy Walking Program among occupational population].

    Science.gov (United States)

    Jiang, W; Zhao, Y F; Yang, X Z; Li, Y C; Li, Z X; Wang, L H

    2018-05-06

    Objective: To examine the effects and associated factors of the China Motivational Healthy Walking Program among occupational population. Methods: The 2016 China Motivational Healthy Walking Program recruited 29 224 participants from 139 demonstration areas for comprehensive prevention and control of chronic and non-communicable disease at national level and 70 at provincial level. Intervention on walking was carried out by adopting group and individual motivating measures. Walking steps were recorded by electronic pedometer. We used percent of days achieving 10 000 steps (P10 000), percent of days fulfilling continuous walking (PCW), and proportion of valid walking (PVW) steps to reflect walking quantity, pattern and quality of participants. Motivation intensity was measured by summing up scores of each motivating activity. Questionnaire-based online survey collected information about demographic characteristics, lifestyle risk factors and chronic diseases. This study finally included 12 368 individuals in the analysis. Multilevel logistic regression model was used to assess the effect of group and individual motivating measures on walking activity and corresponding associated factors. Results: Age of the study sample was (41.2±8.99) years, and 58.17% (7 194) of them were female. After 100-day intervention, the P10 000, PCW and PVW of all participants were 93.89%±14.42%,92.01%±15.97% and 81.00%±7.45%, respectively. The mean P10 000 and PCW increased with rising group-motivated scores, self-motivated scores and individual-activity scores ( Pmotivated scores and self-motivated scores (both Pmotivated scores and self-motivated scores tended to have more likelihood of high-level of P10 000 and PCW. Age, sex, smoking status, education attainment and alcohol drinking were associated with P10 000 and PCW ( PMotivational Healthy Walking Program had positive effect on promoting healthy walking among occupational population. Group-motivated and self-motivated activities

  2. Association between systemic inflammation and serum prostate-specific antigen in a healthy Korean population

    Science.gov (United States)

    Yun, Jonghyun; Lee, Hyunyoung; Yang, Wonjae

    2017-01-01

    Objective Serum prostate-specific antigen (PSA) may be elevated in healthy men with systemic inflammation. We aimed to investigate the association between systemic inflammation markers and serum PSA in a healthy Korean population. Material and methods A cohort of 20,151 healthy native Korean men without prostate disease between the ages of 40 and 65 years who underwent medical checkups were studied from January 2007 to December 2013. Serum total PSA and serum C-reactive protein concentrations, neutrophil, lymphocyte, and platelet counts were determined. The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were calculated. We checked the correlation between systemic inflammation markers and PSA. Results Data obtained from 18,800 healthy men were analyzed. The mean age of the study subjects was 50.72±7.62 years and the mean NLR was 1.764±0.804. Correlation analysis after adjustment for age and body mass index (BMI) revealed that neutrophil count (coefficient = 0.028, p value <0.001), and NLR (coefficient = 0.027, p value <0.001) correlated with PSA. Multivariate analysis using the full model revealed that age, neutrophil count and NLR were positively correlated with PSA (p<0.001, 0.001, and 0.043 respectively). Multivariate analysis using a stepwise model revealed that age, neutrophil count and NLR were positively correlated with PSA (p<0.001, 0.001, and 0.040, respectively) and BMI was negatively correlated with PSA (p<0.001). Conclusion Systemic inflammation markers are useful with a serum PSA in a healthy Korean population. NLR in particular is significantly associated with serum PSA. PMID:28861299

  3. Healthy eating habits among the population of Serbia: gender and age differences.

    Science.gov (United States)

    Jovičić, Ana Đ

    2015-03-01

    The purpose of the study is to examine healthy eating habits of the population of Serbia through three dimensions: knowledge, problems, and feelings as well as to determine whether there are any differences between genders and among different age-groups. The research instrument was an Eating Habits Questionnaire (EHQ) which consisted of 35 items. There were 382 respondents involved in the study. The reliability and factor structure of the questionnaire were verified by using factor analysis. The results of MANOVA showed that there is a significant difference in the habits concerning healthy eating between men and women [F (3,378)=4.26, p=0.006; Wilks' Lambda=0.97]. When the results for the dependent variables (knowledge, problems, and feelings) were considered separately, it was determined that there is no significant difference between men and women, which confirms the results of the t-test. The effect of age on the three dimensions of healthy eating habits was examined within three age-groups, by using ANOVA. The results showed that knowledge about healthy eating increases with age [F (2,379)=6.14, p=0.002] as well as positive feelings which occur as a result of healthy eating [F (2,379)=3.66, p=0.027]. Unlike ANOVA, MANOVA showed difference among the age-groups only when it came to the 'knowledge' variable. This study is important as it shows the current state of awareness on healthy eating habits in the researched populace and may be the basis for further research in this field in Serbia.

  4. Benefits of regular aerobic exercise for executive functioning in healthy populations.

    Science.gov (United States)

    Guiney, Hayley; Machado, Liana

    2013-02-01

    Research suggests that regular aerobic exercise has the potential to improve executive functioning, even in healthy populations. The purpose of this review is to elucidate which components of executive functioning benefit from such exercise in healthy populations. In light of the developmental time course of executive functions, we consider separately children, young adults, and older adults. Data to date from studies of aging provide strong evidence of exercise-linked benefits related to task switching, selective attention, inhibition of prepotent responses, and working memory capacity; furthermore, cross-sectional fitness data suggest that working memory updating could potentially benefit as well. In young adults, working memory updating is the main executive function shown to benefit from regular exercise, but cross-sectional data further suggest that task-switching and post error performance may also benefit. In children, working memory capacity has been shown to benefit, and cross-sectional data suggest potential benefits for selective attention and inhibitory control. Although more research investigating exercise-related benefits for specific components of executive functioning is clearly needed in young adults and children, when considered across the age groups, ample evidence indicates that regular engagement in aerobic exercise can provide a simple means for healthy people to optimize a range of executive functions.

  5. Cerebral Hemodynamics in a Healthy Population Measured by Dynamic Susceptibility Contrast MR Imaging

    International Nuclear Information System (INIS)

    Helenius, J.; Soinne, L.; Tatlisumak, T.; Kaste, M.; Aronen, H.J.

    2003-01-01

    Purpose: To establish reference data and to study age-dependency for cerebral perfusion in various regions of the brain in a healthy population. Material and Methods: Eighty healthy subjects of both genders from 22 to 85 years of age were studied with spin echo echo-planar dynamic susceptibility contrast MR imaging (DSC MRI) at 1.5 T. Cerebral blood volume (CBV), cerebral blood flow (CBF), and contrast agent mean transit time (MTT) were calculated bilaterally for 20 distinct neuro anatomic structures. Results: In gray matter, the following values were found (mean ± SD): CBV (4.6 ± 1.0 ml/100 g), CBF (94.2 ± 23.0 ml/100 g/min), and MTT (3.0 ± 0.6 s), and in white matter: CBV (1.3 ± 0.4 ml/100 g), CBF (19.6 ± 5.8 ml/100 g/min), and MTT (4.3 ± 0.7 s). The perfusion parameters did not change with age, except for a tendency to an increase in gray matter MTT and CBV. Males exhibited higher MTT and CBV than females. No hemispheric difference was found in either gender. Conclusion: Cerebral hemodynamics can be assessed with DSC MRI. Age itself seems to have only a marginal effect on cerebral perfusion in healthy population

  6. Cerebral Hemodynamics in a Healthy Population Measured by Dynamic Susceptibility Contrast MR Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Helenius, J.; Soinne, L.; Tatlisumak, T.; Kaste, M. [Helsinki Univ. Central Hospital (Finland). Dept. of Neurology; Perkioe, J.; Salonen, O.; Savolainen, S. [Helsinki Univ. Central Hospital (Finland). Dept. of Radiology; Oestergaard, L. [Aarhus Univ. Hospital (Denmark). Dept. of Neuroradiology; Carano, R.A.D. [Synarc Inc., San Francisco, CA (United States); Aronen, H.J. [Helsinki Brain Research Center (Finland). Functional Brain Imaging Unit

    2003-09-01

    Purpose: To establish reference data and to study age-dependency for cerebral perfusion in various regions of the brain in a healthy population. Material and Methods: Eighty healthy subjects of both genders from 22 to 85 years of age were studied with spin echo echo-planar dynamic susceptibility contrast MR imaging (DSC MRI) at 1.5 T. Cerebral blood volume (CBV), cerebral blood flow (CBF), and contrast agent mean transit time (MTT) were calculated bilaterally for 20 distinct neuro anatomic structures. Results: In gray matter, the following values were found (mean {+-} SD): CBV (4.6 {+-} 1.0 ml/100 g), CBF (94.2 {+-} 23.0 ml/100 g/min), and MTT (3.0 {+-} 0.6 s), and in white matter: CBV (1.3 {+-} 0.4 ml/100 g), CBF (19.6 {+-} 5.8 ml/100 g/min), and MTT (4.3 {+-} 0.7 s). The perfusion parameters did not change with age, except for a tendency to an increase in gray matter MTT and CBV. Males exhibited higher MTT and CBV than females. No hemispheric difference was found in either gender. Conclusion: Cerebral hemodynamics can be assessed with DSC MRI. Age itself seems to have only a marginal effect on cerebral perfusion in healthy population.

  7. Intercomparison of Finnish and Russian whole-body counters used for the determination of 137Cs body burden in reindeer-herding populations

    International Nuclear Information System (INIS)

    Rahola, T.; Tillander, M.

    1995-01-01

    Intercalibration is a very important quality control in whole-body counting, as the human body is a very difficult ''sample'' to calibrate for. In 1994 the Finnish Centre for Radiation and Nuclear Safety (STUK), the Laboratory of Radiochemistry of the University of Helsinki and the Institute of Radiation Hygiene (IRH) of St. Petersburg agreed to undertake the first Finnish-Russian intercalibration project for whole-body counters. The monitoring of body burdens of indigenous inhabitants in the far north of Russia, from the Kola Peninsula to Chuhodka, has been the responsibility of the ISH since 1960; the above-.mentioned Finnish institutes have monitored reindeer breeders in Finnish Lapland since 1961. The intercalibration was done in the field by measuring the same persons with both systems in Finnish Lapland and in the Kola Peninsula. Mean body burdens in the reindeer-herding population in the areas of current interest are presented in the present paper. 7 refs., 3 figs., 1 tab

  8. The Organization of Social Support of the Population of Siberia in the Years of Russian-Japanese War (1904–1905

    Directory of Open Access Journals (Sweden)

    Tatiana A. Kattsina

    2015-09-01

    Full Text Available The article is devoted to a problem of the organization of the social help to the population in extreme conditions of wars of the beginning of the XX century. Using materials of Siberia, the author reveals the main directions of development and realization of social support of families of the lower military ranks, gives an assessment to its productivity from the point of view of the level of availability and the practice which is formed on places. Research leads to a conclusion that in the years of Russian-Japanese war social support was formed under the influence of local features and local understanding that created differentiation of its level and conditions of access; gaps of the legislation not only reduced aid effectiveness, but also did harm to value of the help.

  9. Allele and Genotype Distributions of DNA Repair Gene Polymorphisms in South Indian Healthy Population

    Directory of Open Access Journals (Sweden)

    Katiboina Srinivasa Rao

    2014-01-01

    Full Text Available Various DNA repair pathways protect the structural and chemical integrity of the human genome from environmental and endogenous threats. Polymorphisms of genes encoding the proteins involved in DNA repair have been found to be associated with cancer risk and chemotherapeutic response. In this study, we aim to establish the normative frequencies of DNA repair genes in South Indian healthy population and compare with HapMap populations. Genotyping was done on 128 healthy volunteers from South India, and the allele and genotype distributions were established. The minor allele frequency of Xeroderma pigmentosum group A ( XPA G23A, Excision repair cross-complementing 2 ( ERCC2 /Xeroderma pigmentosum group D ( XPD Lys751Gln, Xeroderma pigmentosum group G ( XPG His46His, XPG Asp1104His, and X-ray repair cross-complementing group 1 ( XRCC1 Arg399Gln polymorphisms were 49.2%, 36.3%, 48.0%, 23.0%, and 34.0% respectively. Ethnic variations were observed in the frequency distribution of these polymorphisms between the South Indians and other HapMap populations. The present work forms the groundwork for cancer association studies and biomarker identification for treatment response and prognosis.

  10. Effects of serum phosphorus on vascular calcification in a healthy, adult population: A systematic review.

    Science.gov (United States)

    Sheridan, Kristin; Logomarsino, John V

    2017-09-01

    Cardiovascular disease has been associated with elevated serum phosphorus levels, which have been associated with cardiovascular mortality. This is commonly seen in the chronic kidney disease (CKD) population where studies have shown that high phosphorus levels cause coronary artery calcification. Although studies have independently associated vascular stiffness and serum phosphorus in those with and without CKD, there are fewer data in individuals without CKD. Therefore, the aim of this systematic review was to analyze whether serum phosphorus levels are associated with cardiovascular calcification in healthy individuals. A systematic review of the literature that was conducted revealed 10 articles, all cross-sectional studies, that met eligibility criteria. These criteria were peer-reviewed studies on a healthy, adult population written in the English language. Studies lacking data on serum phosphorus and measured to assess its association with vascular calcification were excluded. Studies on subjects with CKD, other chronic diseases, or on children were also excluded. Of the 10 studies located, 8 indicated an association between serum phosphorus and vascular calcification. One study did not indicate an association. One study indicated a statistically significant association between serum phosphorus and vascular calcification prevalence, but not incidence. Studies were limited since no randomized controlled trials were available. This systematic review generates gaps in research. Due to considerable amounts of phosphorus additives in the food supply, there may be a connection to dietary phosphorus and vascular calcification. Additionally, phosphorus binders may assist in the prevention of vascular calcification but have not been studied in a healthy population. Further study on both dietary phosphorus restriction and phosphorus binders is needed. While 8 out of 10 cross-sectional studies found an association in this systematic review, the topic of vascular

  11. ASPECTS OF COMMODIFICATION OF RUSSIAN IN FINLAND

    Directory of Open Access Journals (Sweden)

    Ханнес Виимаранта

    2017-12-01

    Full Text Available This article examines the commodification of Russian in Finland, where recent decades have seen a sharp rise in the size of the Russian-speaking population and the number of tourists from Russia. We particularly consider the use of Russian in the fields of traditional and medical tourism, education, and culture - all of them areas where Russian tourists show a strong preference for services in their native language. The need to provide a variety of services in Russian means that proficiency in Russian is a sig-nificant asset on the job market, both for immigrants and for the relatively small number of Finns who can speak the language. We also note that there is considerable demand among Russian-speaking parents in Fin-land for educational services to supplement their children’s school education.

  12. Nasal carriage of Methicillin-resistant Staphylococcus aureus among healthy population of Kashmir, India

    Directory of Open Access Journals (Sweden)

    B A Fomda

    2014-01-01

    Full Text Available Background: Nasal colonisation with community acquired methicillin resistant Staphylococcus aureus (CA-MRSA is being increasingly reported, especially in places where people are in close contact and where hygiene is compromised. The aim of this study was to find out prevalence of methicillin resistant S.aureus (MRSA colonising anterior nares of healthy subjects. Materials and Methods: Nasal swabs of healthy subjects were collected aseptically and cultured using standard microbiological protocols. Antibiotic susceptibility was done by Kirby-Bauer disc diffusion method according to CLSI guidelines. Methicillin resistance was detected by cefoxitin disc diffusion method and confirmed by minimum inhibitory concentration (MIC and amplification of mecA gene by PCR. Strain typing of MRSA strains was done by PFGE. Results: Out of 820 samples, S.aureus was isolated from 229 (27.92% subjects. Of the 229 isolates, 15 were methicillin resistant. All S. aureus isolates were susceptible to vancomycin. Nasal carriage of MRSA was found to be 1.83% among healthy population. The isolates were found to be polyclonal by PFGE analysis. Conclusion: High prevalence of MRSA is a cause of concern and strategies to interrupt transmission should be implemented.

  13. Russian muscles

    International Nuclear Information System (INIS)

    Soerheim, Paul

    2004-01-01

    A tightening of the electric power balance in the Nordic countries and increased focus on the supply reliability have made the power import from Russia increasingly more important. The two most important players in the Russian power market are the state-owned companies RAO UES and RosEnergoAtom. RAO UES has already begun to strengthen its presence in the Nordic market. There are indications that there are limits to the growth of power import from Russia, and the Nordic power market cannot be based on it in the future

  14. Population pharmacokinetics of nalmefene in healthy subjects and its relation to μ-opioid receptor occupancy.

    Science.gov (United States)

    Kyhl, Lars-Erik Broksoe; Li, Shen; Faerch, Kirstine Ullitz; Soegaard, Birgitte; Larsen, Frank; Areberg, Johan

    2016-02-01

    The aims of this study were to develop a population pharmacokinetic (PK) model to describe the PK of nalmefene in healthy subjects and to relate the exposure of nalmefene to the μ-opioid receptor occupancy by simulations in the target population. Data from nine phase I studies (243 subjects) with extensive blood sampling were pooled and used for the population PK model building. Data from four other phase I studies (85 subjects) were pooled and used as an external validation dataset. Eight subjects from an imaging study contributed occupancy data and the pharmacokinetic/pharmacodynamic (PK/PD) relationship was modelled. Combining the population PK model and the PK/PD relationship enabled simulations to predict μ-opioid occupancy. A two compartment model with first order absorption best described the nalmefene PK data. The typical subject in the population was estimated to have a systemic clearance of 60.4 l h(-1) and a central volume of distribution of 266 l. Absolute oral bioavailability was estimated to 41% without food intake and with food about 53%. Simulation of the μ-opioid receptor occupancy shows that the 95% confidence bound is within or above 60-90% occupancy for up to 22-24 h after a single dose of 20 mg nalmefene. A robust population PK model for nalmefene was developed. Based on the concentration-occupancy model the μ-opioid receptor occupancy after a single 20 mg dose of nalmefene is predicted to be above the target therapeutic occupancy for about 24 h in about 95% of the target population. © 2015 The British Pharmacological Society.

  15. Can Functional Cardiac Age be Predicted from ECG in a Normal Healthy Population

    Science.gov (United States)

    Schlegel, Todd; Starc, Vito; Leban, Manja; Sinigoj, Petra; Vrhovec, Milos

    2011-01-01

    In a normal healthy population, we desired to determine the most age-dependent conventional and advanced ECG parameters. We hypothesized that changes in several ECG parameters might correlate with age and together reliably characterize the functional age of the heart. Methods: An initial study population of 313 apparently healthy subjects was ultimately reduced to 148 subjects (74 men, 84 women, in the range from 10 to 75 years of age) after exclusion criteria. In all subjects, ECG recordings (resting 5-minute 12-lead high frequency ECG) were evaluated via custom software programs to calculate up to 85 different conventional and advanced ECG parameters including beat-to-beat QT and RR variability, waveform complexity, and signal-averaged, high-frequency and spatial/spatiotemporal ECG parameters. The prediction of functional age was evaluated by multiple linear regression analysis using the best 5 univariate predictors. Results: Ignoring what were ultimately small differences between males and females, the functional age was found to be predicted (R2= 0.69, P ECGs, functional cardiac age can be estimated by multiple linear regression analysis of mostly advanced ECG results. Because some parameters in the regression formula, such as QTcorr, high frequency QRS amplitude and P-wave width also change with disease in the same direction as with increased age, increased functional age of the heart may reflect subtle age-related pathologies in cardiac electrical function that are usually hidden on conventional ECG.

  16. Effects of mindfulness-based interventions on biomarkers in healthy and cancer populations: a systematic review.

    Science.gov (United States)

    Sanada, Kenji; Alda Díez, Marta; Salas Valero, Montserrat; Pérez-Yus, María C; Demarzo, Marcelo M P; Montero-Marín, Jesús; García-Toro, Mauro; García-Campayo, Javier

    2017-02-23

    Only a small number of articles have investigated the relationship between mindfulness-based interventions (MBIs) and biomarkers. The aim of this systematic review was to study the effect of MBIs on specific biomarkers (cytokines, neuropeptides and C-reactive protein (CRP)) in both healthy subjects and cancer patients. A search was conducted using PubMed, EMBASE, PsycINFO and the Cochrane library between 1980 and September 2016. A total of 13 studies with 1110 participants were included. In the healthy population, MBIs had no effect on cytokines, but were found to increase the levels of the neuropeptide insulin-like growth factor 1 (IGF-1). With respect to neuropeptide Y, despite the absence of post-intervention differences, MBIs may enhance recovery from stress. With regard to CRP, MBIs could be effective in lower Body Mass Index (BMI) individuals. In cancer patients, MBIs seem to have some effect on cytokine levels, although it was not possible to determine which specific cytokines were affected. One possibility is that MBIs might aid recovery of the immune system, increasing the production of interleukin (IL)-4 and decreasing interferon gamma (IFN-γ). MBIs may be involved in changes from a depressive/carcinogenic profile to a more normalized one. However, given the complexity and different contexts of the immune system, and the fact that this investigation is still in its preliminary stage, additional randomized controlled trials are needed to further establish the impact of MBI programmes on biomarkers in both clinical and non-clinical populations.

  17. The association between arterial stiffness and left ventricular filling pressure in an apparently healthy Korean population

    Directory of Open Access Journals (Sweden)

    Kim Hack-Lyoung

    2013-01-01

    Full Text Available Abstract Background The aim of this study is to investigate the association between arterial stiffness and left ventricular filling pressure in an apparently healthy Korean population. Methods A total of 115 healthy subjects without known cardiovascular risk factors or overt heart disease who underwent both transthoracic echocardiography and brachial-ankle pulse wave velocity (baPWV measurement at the same day during their routine check-ups were analyzed. Results The mean age of study subjects was 52.8 ± 8.4 years, and 78 (67.8% were men. The mean baPWV value was 1,325 ± 185 cm/s. Study subjects were divided into 3 groups according to E/E’ value: subjects with E/E’ p β = 0.371, p after controlling confounders including age, sex and body mass index. In receiver-operating characteristic (ROC curve analysis, the sensitivity and specificity for detection of E/E’ ≥ 10 were 78.6% and 59.8%, respectively with mean baPWV of 1,282 cm/s as the cut off value. The discriminatory capacity for predicting E/E’ ≥ 10 was improved from an area under the ROC curve of 0.646 with age alone to 0.734 when baPWV was added (p Conclusions There is a significant association between baPWV and E/E’ in an apparently healthy Korean population. BaPWV is useful as a simple and non-invasive method for early detection of increased LV filling pressure among these people.

  18. Investigating pulmonary and systemic pharmacokinetics of inhaled olodaterol in healthy volunteers using a population pharmacokinetic approach.

    Science.gov (United States)

    Borghardt, Jens Markus; Weber, Benjamin; Staab, Alexander; Kunz, Christina; Formella, Stephan; Kloft, Charlotte

    2016-03-01

    Olodaterol, a novel β2-adrenergic receptor agonist, is a long-acting, once-daily inhaled bronchodilator approved for the treatment of chronic obstructive pulmonary disease. The aim of the present study was to describe the plasma and urine pharmacokinetics of olodaterol after intravenous administration and oral inhalation in healthy volunteers by population pharmacokinetic modelling and thereby to infer its pulmonary fate. Plasma and urine data after intravenous administration (0.5-25 μg) and oral inhalation (2.5-70 μg via the Respimat® inhaler) were available from a total of 148 healthy volunteers (single and multiple dosing). A stepwise model building approach was applied, using population pharmacokinetic modelling. Systemic disposition parameters were fixed to estimates obtained from intravenous data when modelling data after inhalation. A pharmacokinetic model, including three depot compartments with associated parallel first-order absorption processes (pulmonary model) on top of a four-compartment body model (systemic disposition model), was found to describe the data the best. The dose reaching the lung (pulmonary bioavailable fraction) was estimated to be 49.4% [95% confidence interval (CI) 46.1, 52.7%] of the dose released from the device. A large proportion of the pulmonary bioavailable fraction [70.1% (95% CI 66.8, 73.3%)] was absorbed with a half-life of 21.8 h (95% CI 19.7, 24.4 h). The plasma and urine pharmacokinetics of olodaterol after intravenous administration and oral inhalation in healthy volunteers were adequately described. The key finding was that a high proportion of the pulmonary bioavailable fraction had an extended pulmonary residence time. This finding was not expected based on the physicochemical properties of olodaterol. © 2015 The British Pharmacological Society.

  19. Russian Medieval Military Architecture

    Directory of Open Access Journals (Sweden)

    Rappoport, Pavel

    1969-12-01

    Full Text Available In Russia defensive works were not less important than in Western Europe. Russian chronicles are full of reports of the building of towns, of their siege and defence. In Ancient Russian the word town meant not a town in the modern sense, but only a fortified settlement as distinct from an unfortified one. Thus the concept town applied to medieval towns proper and to citadels, feudal castles and even fortified villages. Every population centre with a wall round it was called a town. Moreover, until the 17th century this word was frequently applied to mean the fortifications themselves.

  20. Russian Federation

    International Nuclear Information System (INIS)

    2001-01-01

    In the Russian Federation (RF), management of radioactive wastes will be carried out within the framework of the Federal Target Program for management of radioactive wastes and used nuclear materials for the period 1996-2005. The agency within the RF responsible for this program is the Ministry of Russian Federation on Atomic Energy. Current radioactive waste disposal activities are focused on creating regional repositories for wastes generated by radiochemical production, nuclear reactors, science centers, and from other sources outside of the nuclear-fuel cycle (the latter wastes are managed by Scientific and Industrial Association, 'RADON'). Wastes of these types are in temporary storage, with the exception of non-fuel cycle wastes which are in long term storage managed by SAI 'RADON'. The criteria for segregating between underground or near-surface disposal of radioactive waste are based on the radiation fields and radionuclide composition of the wastes. The most progress in creating regional repositories has been made in the Northwest region of Russia. However, development of a detailed design has begun for a test facility in the Northeast for disposal of radioactive wastes generated in Murmansk and Arkhangelsk provinces. The feasibility study for construction of this facility is being evaluated by state monitoring organizations, the heads of administrations of the Arkhangelsk and Murmansk provinces, and Minatom of Russia

  1. Prevalence of viral hepatitis (B and C serological markers in healthy working population

    Directory of Open Access Journals (Sweden)

    José Luis Calleja-Panero

    2013-06-01

    Full Text Available Introduction and objectives: prevalence of viral hepatitis (B and C changes geographically. Our aim was to determinate the prevalence of hepatitis B (HBV and hepatitis C virus (HCV serological markers in healthy working population and to describe the epidemiological characteristics associated to its presence. Methods: blood samples and epidemiological data of 5,017 healthy workers from Murcia and Madrid were recorded prospectively. Results: a total of 5,017 healthy volunteers participated. Mean age 39 ± 11 years, men predominance (73 %. Prevalence of serological markers of HCV and HBV was 0.6 % and 0.7 %. Age of patients with HCV antibody was significantly higher (43 ± 9 years vs. 39 ± 11 years; p = 0.03. We observed significant differences in liver test values (alanine aminotransferase [ALT] 64 ± 56 IU/L vs. 28 ± 20 IU/L; p < 0.001; aspartate aminotransferase [AST] (51 ± 45 IU/L vs. 23 ± 12 IU/L; p < 0.001 and in gamma-glutamyltransferase (GGT value (104 ± 122 IU/L vs. 37 ± 46 IU/L; p < 0.001. The presence of HCV antibody was related significantly to previous transfusion (13 % vs. 5 %; p = 0.03, tattoos (29 % vs. 13 %; p < 0.01, intravenous drug addiction (13 % vs. 0.2 %; p < 0.001 and coexistence with people with positive HCV antibody (16 % vs. 4 %; p < 0.001. In HBV no differences in basal characteristics were observed with exception in AST values (29 ± 15 IU/L vs. 23 ± 12 IU/L; p < 0.01. Hepatitis B surface antigen (HBsAg was related significantly to previous transfusion (15 % vs. 5 %; p < 0.01, tattoos (26 % vs. 14 %; p = 0.04 and coexistence with people with positive HBsAg (17 % vs. 4 %; p < 0.001. Conclusions: prevalence of serological markers in healthy working population is low. Risk factors for infection were previous transfusion and tattoos. Intravenous drug addiction was only a risk factor in HCV.

  2. Gait Complexity and Regularity Are Differently Modulated by Treadmill Walking in Parkinson's Disease and Healthy Population

    Directory of Open Access Journals (Sweden)

    Thibault Warlop

    2018-02-01

    Full Text Available Variability raises considerable interest as a promising and sensitive marker of dysfunction in physiology, in particular in neurosciences. Both internally (e.g., pathology and/or externally (e.g., environment generated perturbations and the neuro-mechanical responses to them contribute to the fluctuating dynamics of locomotion. Defective internal gait control in Parkinson's disease (PD, resulting in typical timing gait disorders, is characterized by the breakdown of the temporal organization of stride duration variability. Influence of external cue on gait pattern could be detrimental or advantageous depending on situations (healthy or pathological gait pattern, respectively. As well as being an interesting rehabilitative approach in PD, treadmills are usually implemented in laboratory settings to perform instrumented gait analysis including gait variability assessment. However, possibly acting as an external pacemaker, treadmill could modulate the temporal organization of gait variability of PD patients which could invalidate any gait variability assessment. This study aimed to investigate the immediate influence of treadmill walking (TW on the temporal organization of stride duration variability in PD and healthy population. Here, we analyzed the gait pattern of 20 PD patients and 15 healthy age-matched subjects walking on overground and on a motorized-treadmill (randomized order at a self-selected speed. The temporal organization and regularity of time series of walking were assessed on 512 consecutive strides and assessed by the application of non-linear mathematical methods (i.e., the detrended fluctuation analysis and power spectral density; and sample entropy, for the temporal organization and regularity of gait variability, respectively. A more temporally organized and regular gait pattern seems to emerge from TW in PD while no influence was observed on healthy gait pattern. Treadmill could afford the necessary framework to regulate gait

  3. [Investigation of the situation of vaginal microflora in healthy women population].

    Science.gov (United States)

    Ji, Fang; Zhang, Ning; Di, Wen; Liao, Qin-ping; Wang, Wen; Zhao, Xiao-ming; Sun, Yun; Liu, Zhao-hui

    2009-01-01

    To assess the distribution of vaginal microflora in healthy women and investigate their cognition of lower reproductive tract infection-related knowledge as well as personal hygiene habits and character of behavior in seeking medical treatment. Total of 1660 healthy women who had physical check-ups at the Medical Center of Renji Hospital were selected and received gynecologic examination, as well as routine examination, pH examination and bacterial culture of the vaginal discharge. In addition, 860 of them were randomly selected for questionnaire survey, in which reproductive tract infection -related knowledge and personal hygiene habits as well as behavior in seeking medical treatment were involved. Among the 1660 censused women, vaginal average pH was 4. 16 +/- 0.21. The positive rate of Candida in vaginal discharge routine examination was 3.86% (64/1660), which was lower than that in aerobes culture 7.71% (128/1660). Candida albicans was the most populous species 78.9% (101/128), followed by 7.8% (10/128) and 7.0% (9/128) for the Candida glabrata and Candida krusei respectively. The most populous species of vaginal microflora were hemolytic streptococcus A (63.80%, 1059/1660), Staphylococcus epidermidis (14.28%, 237/1660), and Enterococcus faecalis (D) group (11.44%, 190/1660). The questionnaire survey showed that 88.4% (760/860) of 860 women took active treatment when feeling unwell, 92.1% (792/860) of them had good hygiene practices, and only 21.2% (182/860) had the habit of vaginal douching. In addition, 50.0% (430/860) of them had the desire to obtain reproductive health knowledge through out-patient consultation. Vulvovaginal Candida disease ranks the first in all types of vaginitis, among which, Candida albicans is the most populous species followed by the Candida glabrata and Candida krusei. Hemolytic streptococcus A and Staphylococcus epidermidis are the most common species of vaginal microflora in healthy women. The censused women have high awareness of

  4. Testing the limits of Rodent Sperm Analysis: azoospermia in an otherwise healthy wild rodent population.

    Science.gov (United States)

    Tannenbaum, Lawrence V; Thran, Brandolyn H; Willams, Keith J

    2009-01-01

    By comparing the sperm parameters of small rodents trapped at contaminated terrestrial sites and nearby habitat-matched noncontaminated locations, the patent-pending Rodent Sperm Analysis (RSA) method provides a direct health status appraisal for the maximally chemical-exposed mammalian ecological receptor in the wild. RSA outcomes have consistently allowed for as definitive determinations of receptor health as are possible at the present time, thereby streamlining the ecological risk assessment (ERA) process. Here, we describe the unanticipated discovery, at a contaminated US EPA Superfund National Priorities List site, of a population of Hispid cotton rats (Sigmodon hispidus), with a high percentage of adult males lacking sperm entirely (azoospermia). In light of the RSA method's role in streamlining ERAs and in bringing contaminated Superfund-type site investigations to closure, we consider the consequences of the discovery. The two matters specifically discussed are (1) the computation of a population's average sperm count where azoospermia is present and (2) the merits of the RSA method and its sperm parameter thresholds-for-effect when azoospermia is masked in an otherwise apparently healthy rodent population.

  5. Phenotypic differences in leucocyte populations among healthy preterm and full-term newborns.

    Science.gov (United States)

    Quinello, C; Silveira-Lessa, A L; Ceccon, M E J R; Cianciarullo, M A; Carneiro-Sampaio, M; Palmeira, P

    2014-07-01

    The immune system of neonates has been considered functionally immature, and due to their high susceptibility to infections, the aim of this study was to analyse the phenotypic differences in leucocyte populations in healthy preterm and full-term newborns. We evaluated the absolute numbers and frequencies of dendritic cells (DCs) and DC subsets, monocytes and T and B lymphocytes and subsets in the cord blood of healthy moderate and very preterm (Group 1), late preterm (Group 2) and full-term (Group 3) newborns and in healthy adults, as controls, by flow cytometry. The analyses revealed statistically higher absolute cell numbers in neonates compared with adults due to the characteristic leucocytosis of neonates. We observed a lower frequency of CD80(+) myeloid and plasmacytoid DCs in Group 1 and reduced expression of TLR-4 on myeloid DCs in all neonates compared with adults. TLR-2(+) monocytes were reduced in Group 1 compared with Groups 2 and 3, and TLR-4(+) monocytes were reduced in Groups 1 and 2 compared with Group 3. The frequencies and numbers of naïve CD4(+) T and CD19(+) B cells were higher in the three groups of neonates compared with adults, while CD4(+) effector and effector memory T cells and CD19(+) memory B cells were elevated in adults compared with neonates, as expected. Our study provides reference values for leucocytes in cord blood from term and preterm newborns, which may facilitate the identification of immunological deficiencies in protection against extracellular pathogens. © 2014 John Wiley & Sons Ltd.

  6. Spatial genetic structure of Long-tailed Ducks (Clangula hyemalis) among Alaskan, Canadian, and Russian breeding populations

    Science.gov (United States)

    Wilson, Robert E.; Gust, J R; Petersen, Margaret; Talbot, Sandra L.

    2016-01-01

    Arctic ecosystems are changing at an unprecedented rate. How Arctic species are able to respond to such environmental change is partially dependent on the connections between local and broadly distributed populations. For species like the Long-tailed Duck (Clangula hyemalis), we have limited telemetry and band-recovery information from which to infer population structure and migratory connectivity; however, genetic analyses can offer additional insights. To examine population structure in the Long-tailed Duck, we characterized variation at mtDNA control region and microsatellite loci among four breeding areas in Alaska, Canada, and Russia. We observed significant differences in the variance of mtDNA haplotype frequencies between the Yukon-Kuskokwim Delta (YKD) and the three Arctic locations (Arctic Coastal Plain in Alaska, eastern Siberia, and central Canadian Arctic). However, like most sea duck genetic assessments, our study found no evidence of population structure based on autosomal microsatellite loci. Long-tailed Ducks use multiple wintering areas where pair formation occurs with some populations using both the Pacific and Atlantic Oceans. This situation provides a greater opportunity for admixture across breeding locales, which would likely homogenize the nuclear genome even in the presence of female philopatry. The observed mtDNA differentiation was largely due to the presence of two divergent clades: (A) a clade showing signs of admixture among all breeding locales and (B) a clade primarily composed of YKD samples. We hypothesize that the pattern of mtDNA differentiation reflects some degree of philopatry to the YKD and isolation of two refugial populations with subsequent expansion and admixture. We recommend additional genetic assessments throughout the circumpolar range of Long-tailed Ducks to further quantify aspects of genetic diversity and migratory connectivity in this species.

  7. Volatile organic compounds in exhaled breath in a healthy population: effect of tobacco smoking.

    Science.gov (United States)

    Jareño-Esteban, José Javier; Muñoz-Lucas, M Ángeles; Carrillo-Aranda, Belén; Maldonado-Sanz, José Ángel; de Granda-Orive, Ignacio; Aguilar-Ros, Antonio; Civera-Tejuca, Concepción; Gutiérrez-Ortega, Carlos; Callol-Sánchez, Luis Miguel

    2013-11-01

    Tobacco smoke is a source of free radicals and reactive oxygen and nitrogen species, which are the main causes of oxidative stress. The analysis of volatile organic compounds (VOC) in exhaled breath is an indirect method of measuring the level of oxidative stress that occurs in the airways caused by tobacco consumption. The aim of this study was to determine whether smoking influences the production of VOC, in a clinically healthy population. Exhaled breath from 89 healthy volunteers, divided into three groups (non-smokers, ex-smokers and smokers) was analysed. Samples were collected using Bio-VOC® devices and transferred to universal desorption tubes. Chemical compounds were analysed by thermal desorption, gas chromatography and mass spectrometry. We analysed hexanal, heptanal, octanal, nonanal, nonanoic acid and propanoic acid, all identified by retention time and mass spectra referenced in the NIST 08 mass spectral library; confirmation was carried out using reference standards of the pure chemical compound. These VOC were found in very low concentrations. Only nonanal showed significant quantitative and qualitative statistical differences among the study groups. Nonanal concentration is dependent on smoking, but is independent of the amount of tobacco consumed, age and gender. Nonanal in exhaled breath is associated with tobacco consumption, current or previous. Nonanal is a sub-product of the destruction of the cell membrane, and its finding may be indicative of cell damage in smokers. This result appears in many farmers who smoke. Copyright © 2013 SEPAR. Published by Elsevier Espana. All rights reserved.

  8. The Effect of Swimming on the Lung Functions in Healthy Young Male Population of Amritsar

    Directory of Open Access Journals (Sweden)

    Mahajan Shashi

    2013-12-01

    Full Text Available Aim of this research is to study the effects of swimming on the lung functions in adult male population of Amritsar. Many exercise physiologists study the effect of exercise on pathology, and the mechanisms by which exercise can reduce or reverse disease progression. The present study was undertaken to study the effects swimming on the lung functions. Pulmonary function tests (PFTs of swimming trainees were compared with those of controls. We evaluated PFTs in 50 healthy subjects who participated in a 3 months of swimming plan. Pulmonary function tests were recorded before the commencement of swimming and at the end of swimming and compared the values so obtained with 50 healthy non- swimmers who were chosen as controls. The controls were the physiotherapy students from Khalsa College Amritsar. Both were in the age group of 18- 20 years. The PFTs were carried out with a computerized spirometer “Med-Spiror”. The various data was collected, compiled, statistically analysed and valid conclusions were drawn. Higher lung volumes and flow rates were achieved in swimming trainees after their training period, as compared to their own values obtained before their training period and to those of controls. Regular exercise enhances physical capabilities and physiological responses of the human body and also in the lungs. The cause of improved of various respiratory functions and flow rates after  swimming duration was better mechanical factors and lower airway resistance influenced during the training period. Key words: Pulmonary; Expiration; Swimming; Pulmonary Function Test

  9. Seroprevalence of Hepatitis A and E Virus Infections Among Healthy Population in Shiraz, Southern Iran.

    Science.gov (United States)

    Asaei, Sadaf; Ziyaeyan, Mazyar; Moeini, Mahsa; Jamalidoust, Marzieh; Behzadi, Mohammad Amin

    2015-07-01

    Enterically-transmitted acute viral hepatitis is caused predominantly by hepatitis A virus (HAV) and hepatitis E virus (HEV). The prevalence of HEV and HAV infections varies in different geographical regions. This study was conducted to determine the prevalence of HEV and HAV infections among Iranian healthy individuals in southern Iran. Totally, 1030 samples were collected from healthy subjects in schools, those referred to tertiary outpatient clinics and health centers in Shiraz between November 2011 and May 2012. Their ages ranged between six months and 95 years. The presence of total anti-HAV and anti-HEV immunoglobulin M (IgM) in plasma was assessed by ELISA. The results showed that 66.2% and 0.6% of the general population in this area were positive for total anti-HAV and IgM antibodies by ELISA, respectively. As seen, 13.4% and 0.9% were positive for total anti-HEV and IgM antibodies, respectively. The difference in total anti-HAV and anti-HEV antibodies was significant among the age groups (P viruses in the region was high and some high-risk individuals including females at child-bearing age were more susceptible. HAV vaccination could be recommended for antibody-negative adults.

  10. Heritability of circulating growth factors involved in the angiogenesis in healthy human population.

    Science.gov (United States)

    Pantsulaia, I; Trofimov, S; Kobyliansky, E; Livshits, G

    2004-09-21

    The present study examined the extent of genetic and environmental influences on the populational variation of circulating growth factors (VEGF, EGF) involved in angiogenesis in healthy and ethnically homogeneous Caucasian families. The plasma levels of each of the studied biochemical indices were determined by enzyme-linked immunoassay in 478 healthy individuals aged 18-75 years. Quantitative genetic analysis showed that the VEGF and EGF variation was appreciably attributable to genetic effects, with heritability estimates of 79.9% and 48.4%, respectively. Yet, common environmental factors, shared by members of the same household, also played a significant role (P growth factor-beta 1 (TGF-beta 1) or tissue inhibitors of matrix metalloproteinases 1 (TIMP-1), likewise relevant for angiogenesis. Bivariate analysis revealed significant phenotypic correlations (P < 0.002) between all pairs of variables, thus indicating the possible existence of common genetic and environmental factors. The analysis suggested that the pleiotropic genetic effects were consistently the primary (or even the sole) source of correlation between all pairs of studied molecules. The results of our study affirm the existence of specific and common genetic pathways that commonly determine the greater part of the circulating variation of these molecules.

  11. Healthy habits: what kind of guidance the elderly population is receiving from health professionals?

    Science.gov (United States)

    Flores, Thaynã Ramos; Nunes, Bruno Pereira; Assunção, Maria Cecília Formoso; Bertoldi, Andréa Dâmaso

    2016-03-01

    To describe the prevalence of guidance on healthy habits received from health professionals by elderly and its relation to socioeconomic demographic, behavioral and health indicators, and the type of services. Cross sectional population based study including individuals aged 60 years or more in the urban area of Pelotas, Rio Grande do Sul, Brazil. Seven guidance on healthy habits were evaluated: weight control, reduction in salt, sugar and fat intake, physical activity practice, not smoking and not drinking alcohol. Among the 1,451 elderly interviewed, 1,281 (88.3%) consulted in the last year. The orientations more refereed were to fat (61.7%) and salt (61.5%) intake reduction and physical activity (58.2%). Elderly who consulted three times or more and in services financed by the Unified Health System received more guidance. Those elderly from the socioeconomic classes A/B were more likely to receive guidance for weight control (RP = 1.27; 95%CI 1.06 - 1.70) and physical activity (RP = 1.34; 95%CI 1.06 - 1.69). The orientation from health professionals were uncommon and, in some cases, unfocused.

  12. Cognitive Deficits in Healthy Elderly Population With "Normal" Scores on the Mini-Mental State Examination.

    Science.gov (United States)

    Votruba, Kristen L; Persad, Carol; Giordani, Bruno

    2016-05-01

    This study investigated whether healthy older adults with Mini-Mental State Examination (MMSE) scores above 23 exhibit cognitive impairment on neuropsychological tests. Participants completed the MMSE and a neuropsychological battery including tests of 10 domains. Results were compared to published normative data. On neuropsychological testing, participants performed well on measures of naming and recall but showed mild to moderate impairment in working memory and processing speed and marked impairment in inhibition, sustained attention, and executive functioning. Almost everyone (91%) scored at least 1 standard deviation (SD) below the mean in at least 1 domain. The median number of domains in which individuals scored below 1 SD was 3.0 of 10.0, whereas over 21% scored below 1 SD in 5 domains or more. With the strictest of definitions for impairment, 20% of this population scored below 2.0 SDs below the norm in at least 2 domains, a necessary condition for a diagnosis of dementia. The finding that cognitive impairment, particularly in attention and executive functioning, is found in healthy older persons who perform well on the MMSE has clinical and research implications in terms of emphasizing normal variability in performance and early identification of possible impairment. © The Author(s) 2016.

  13. IDENTIFICATION OF PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA IN THE RUSSIAN POPULATION USING THE EXAMPLE OF MOSCOW CITY AND MOSCOW REGION

    Directory of Open Access Journals (Sweden)

    I. V. Sergienko

    2018-01-01

    Full Text Available Aim. To estimate the prevalence of familial hypercholesterolemia (FH in a sample of Moscow city and Moscow region patients with hypercholesterolemia (HCh based on lipid spectrum and instrumental methods.Material and methods. The study included two samples of patients (age >18 years, with total cholesterol (TCh level ≥7.5 mmol/l and/or low-density lipoprotein (LDL cholesterol level ≥4.9 mmol/l. First sample (n=60 was included to determine secondary hyperlipidemia frequency in newly diagnosed HCh, with measurement of thyroid hormone, glucose and glycated hemoglobin (HbA1c levels. Patients of the second sample (n=432 from Russian registry of FH (RuFH were studied by drug therapy assessment, lipid profile measurements, calculation of FH probability according to Dutch and British criteria, carotids duplex scanning (CDS, cardiac perfusion single-photon emission computed tomography (SPECT/CT using rest/stress protocol.Results. The incidence of secondary dyslipidemia due to diabetes or hypothyroidism in patients with severe HCh was 18.3%. Monotherapy with atorvastatin (34.2% or rosuvastatin (31.8%, combined therapy with statins and other lipid-lowering drugs (24.4% prevails in the structure of lipidlowering therapy in patients with severe HCh. The frequency of "definite" FH according to Dutch criteria in HCh patients was 15.3%, "probable" – 18.1%. Patients with definite FH diagnosis showed higher level of TCh (p<0.001, LDL cholesterol (p<0.001, proprotein convertase subtilisin/kexin type 9 (p<0.001, lower high-density lipoprotein (HDL; p=0.02, and triglycerides (p<0.001. At that HDL cholesterol levels differed only in patients treated with lipid-lowering drugs. Patients with lipid-lowering therapy had significantly higher values of total stenosis percent, the number of plaques, intima-media complex thickness (p<0.001. Patients with lipid-lowering therapy with a definite and probable FH diagnosis had significantly worse values of CDS parameters

  14. Fighting in the Mountains and Among the People: Imperial Russian and Early Soviet Population-Centric Counterinsurgency

    Science.gov (United States)

    2015-05-21

    suppression of the Malay insurgency, and the Indonesian counterinsurgency in East Timor. Despite the extensiveness of research on past...authorities embraced Central Asian customs in an attempt to build trust with the local population. In 1921, they undertook a wide-scale ethnographic

  15. Health effects of ambient levels of respirable particulate matter (PM) on healthy, young-adult population

    Science.gov (United States)

    Shaughnessy, William J.; Venigalla, Mohan M.; Trump, David

    2015-12-01

    There is an absence of studies that define the relationship between ambient particulate matter (PM) levels and adverse health outcomes among the young and healthy adult sub-group. In this research, the relationship between exposures to ambient levels of PM in the 10 micron (PM10) and 2.5 micron (PM2.5) size fractions and health outcomes in members of the healthy, young-adult subgroup who are 18-39 years of age was examined. Active duty military personnel populations at three strategically selected military bases in the United States were used as a surrogate to the control group. Health outcome data, which consists of the number of diagnoses for each of nine International Classification of Diseases, 9th Revision (ICD-9) categories related to respiratory illness, were derived from outpatient visits at each of the three military bases. Data on ambient concentrations of particulate matter, specifically PM10 and PM2.5, were obtained for these sites. The health outcome data were correlated and regressed with the PM10 and PM2.5 data, and other air quality and weather-related data on a daily and weekly basis for the period 1998 to 2004. Results indicate that at Fort Bliss, which is a US Environmental Protection Agency designated non-attainment area for PM10, a statistically significant association exists between the weekly-averaged number of adverse health effects in the young and healthy adult population and the corresponding weekly-average ambient PM10 concentration. A least squares regression analysis was performed on the Fort Bliss data sets indicated that the health outcome data is related to several environmental parameters in addition to PM10. Overall, the analysis estimates a .6% increase in the weekly rate of emergency room visits for upper respiratory infections for every 10 μg/m3 increase in the weekly-averaged PM10 concentration above the mean. The findings support the development of policy and guidance opportunities that can be developed to mitigate exposures

  16. Analysis of human blood plasma proteome from ten healthy volunteers from Indian population.

    Directory of Open Access Journals (Sweden)

    Poonam Gautam

    Full Text Available Analysis of any mammalian plasma proteome is a challenge, particularly by mass spectrometry, due to the presence of albumin and other abundant proteins which can mask the detection of low abundant proteins. As detection of human plasma proteins is valuable in diagnostics, exploring various workflows with minimal fractionation prior to mass spectral analysis, is required in order to study population diversity involving analysis in a large cohort of samples. Here, we used 'reference plasma sample', a pool of plasma from 10 healthy individuals from Indian population in the age group of 25-60 yrs including 5 males and 5 females. The 14 abundant proteins were immunodepleted from plasma and then evaluated by three different workflows for proteome analysis using a nanoflow reverse phase liquid chromatography system coupled to a LTQ Orbitrap Velos mass spectrometer. The analysis of reference plasma sample a without prefractionation, b after prefractionation at peptide level by strong cation exchange chromatography and c after prefractionation at protein level by sodium dodecyl sulfate polyacrylamide gel electrophoresis, led to the identification of 194, 251 and 342 proteins respectively. Together, a comprehensive dataset of 517 unique proteins was achieved from all the three workflows, including 271 proteins with high confidence identified by ≥ 2 unique peptides in any of the workflows or identified by single peptide in any of the two workflows. A total of 70 proteins were common in all the three workflows. Some of the proteins were unique to our study and could be specific to Indian population. The high-confidence dataset obtained from our study may be useful for studying the population diversity, in discovery and validation process for biomarker identification.

  17. Frequency of CCR5Δ32 allele in healthy Bosniak population.

    Directory of Open Access Journals (Sweden)

    Grażyna Adler

    2014-08-01

    Full Text Available Recent evidence has demonstrated the role of CCR5Δ32 in a variety of human diseases: from infectious and inflammatory diseases to cancer. Several studies have confirmed that genetic variants in chemokine receptor CCR5 gene are correlated with susceptibility and resistance to HIV infection. A 32-nucleotide deletion within the CCR5 reading frame is associated with decreased susceptibility to HIV acquisition and a slower progression to AIDS. Mean frequency of CCR5Δ32 allele in Europe is approximately 10%. The highest allele frequency is observed among Nordic populations (about 12% and lower in the regions of Southeast Mediterranean (about 5%. Although the frequency of CCR5Δ32 was determined in numerous European populations, there is a lack of studies on this variant in the Bosnia and Hercegovina population. Therefore, the aim of our study was to assess the frequency of CCR5Δ32 allele in the cohort of Bosniaks and compare the results with European reports. CCR5Δ32 was detected by sequence-specific PCR in a sample of 100 healthy subjects from Bosnia and Herzegovina (DNA collected 2011-2013.  Mean age of the cohort being 58.8 (±10.7 years, with 82% of women. We identified 17 heterozygotes and one mutant homozygote in study group, with mean ∆32 allele frequency of 9.5%. CCR5∆32 allele frequency among Bosniaks is comparable to that found in Caucasian populations and follows the pattern of the north-southern gradient observed for Europe. Further studies on larger cohorts with adequate female-to-male ratio are necessary. 

  18. Helicobacter Pylori Associated Antral Gastritis in Peptic Ulcer Disease Patients and Normal Healthy Population of Kashmir, India

    OpenAIRE

    Gh. Jeelani Romshoo; G. M. Malik; M. Youssuf Bhat; Ab. Rashid rather; Javaid Ahmad Basu; Khursheed Ahmad Qureshi

    1998-01-01

    Aim: To study the association of Helicobacter pylori infection with chronic antral gastritis in peptic ulcer disease patients and healthy population of Kashmir. Methods: 50 peptic ulcer patients (duodenal ulcer = 46, gastric ulcer = 2 and combined duodenal and gastric ulcer = 2) and 30 asymptomatic healthy volunteers were included in this study. Peptic ulcer was diagnosed on endoscopic examination. 4–6 punch biopsies were taken from gastric antrum in all the individuals and in case of gastric...

  19. Cephalometric norms for the upper airway in a healthy North Indian population

    Directory of Open Access Journals (Sweden)

    Dipti Shastri

    2015-01-01

    Full Text Available Objective: The aim was to obtain normative data for cephalometric measurements of the upper airway in the North Indian population. Design: Observational study. Setting: University department and teaching hospital out-patient clinic. Subjects and Methods: A total of 180 healthy patients were included out of which 90 were males (age range, 8-16 years, and 90 were females (age range, 8-16 years, with normal skeletal facial profile, no history of snoring, sleep apnea, upper airway disease, tonsillectomy or adenoidectomy, obesity, or pathology in the pharynx. Twenty cephalometric airway measurements, including size of the tongue, soft palate, nasopharynx, oropharynx, hypopharynx, and relative position of the hyoid bone and valleculae were obtained. Landmarks on cephalometric radiographs were digitized and measurements were made using a specially designed computer program. Error analysis of measurements was performed and comparison of measurements according to sex was made. Results: Significant sex dimorphism was seen for the majority of measurements, with the exception of minimal depth of the airway, oropharyngeal depth of the airway, and the soft palate angle with the hard palate. Conclusion: A minimum sagittal dimension of the upper airway was evident despite differences in measurements between sexes. Findings from this study should be a useful reference for the assessment of sleep apnea in the North Indian population.

  20. Important factors governing exposure of the population and countermeasure application in rural settlements of the Russian Federation in the long term after the Chernobyl accident

    International Nuclear Information System (INIS)

    Fesenko, S.; Jacob, P.; Alexakhin, R.; Sanzharova, N.I.; Panov, A.; Fesenko, G.; Cecille, L.

    2001-01-01

    Rural settlements located in areas of the Russian Federation contaminated after the Chernobyl accident and exceeding an annual dose of 1 mSv a -1 have been classified according to 137 Cs contamination density, internal dose and the neighbourhood of forests. It has been shown that, with the exception of the most contaminated areas, the internal doses decreased in accordance with a decline in 137 Cs availability for plant root uptake. An inverse tendency was observed in areas with 137 Cs contamination above 555 kBq m -2 which can be explained by a reduction or even termination of countermeasure application and by an increasing consumption of forest products in areas where restrictive countermeasures are still implemented. Twenty-seven settlements have been studied to estimate the effectiveness of countermeasures applied previously and to identify the most important factors governing the radiation exposure to the population and its change with time. It has been shown that the effectiveness of countermeasures which resulted in a decrease of up to 40% of doses has a tendency to decline in the long term. The need for continuation of remediation in rural settlements was evaluated both for selected settlements and extrapolated to the whole contaminated area and it has been shown that the application of countermeasures will be of importance at least up to the year 2045. Rather high effectiveness in terms of internal dose reduction (factor of 2-2.5) of radical improvement (disking, ploughing and reseeding) and administration of Cs binders to animals (Ferrocyn) was demonstrated for the selected settlements. It could be demonstrated that for forest-remote settlements there is a linear dependence between internal dose normalised to the density of contamination and the proportion of peat soils around settlements. For near-forest settlements, this dependence was less pronounced which can be explained by the high contribution of forest food products to the internal dose. Milk is

  1. Stairs instead of elevators at the workplace decreases PCSK9 levels in a healthy population.

    Science.gov (United States)

    Kamani, Christel H; Gencer, Baris; Montecucco, Fabrizio; Courvoisier, Delphine; Vuilleumier, Nicolas; Meyer, Philippe; Mach, François

    2015-10-01

    Regular physical activity is recommended to lower low-density lipoprotein cholesterol (LDL-C) in a healthy population. Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) was shown to reduce (LDL-C) levels; however, the impact of physical exercise on PCSK9 levels remains unclear. We used data from 67 healthy hospital employees who participated in a 6-month intervention promoting active use of stairs instead of elevators during 3 months, followed by 3 months without recommendation. We confirmed the degree of physical activity with estimated aerobic capacity (VO2 max ) and measured serum PCSK9 levels at baseline, 3 and 6 month. Using a multilevel regression model, we analysed changes of PCSK9 levels over time adjusting for age, gender, aerobic capacity, baseline LDL-C, and LDL-C and body mass index (BMI) changes. At baseline, PCSK9 levels were associated with higher aerobic capacity (P-value = 0·024). At 3 months, we observed a significant decrease in mean PCSK9 levels from 403·6 to 324·3 ng/mL (P-value = 0·001), as well a significant decrease in mean LDL-C levels from 3·5 to 3·3 mM (P-value = 0·01). During this period, mean aerobic capacity (VO2 max ) increased from 37·0 to 40·4 mL/kg/min (P-value < 0·001). Physical activity was independently associated with a decrease in PCSK9 levels after adjustment for age, gender, baseline aerobic capacity, and LDL-C and BMI changes. Daily physical activity at the work place is independently associated with a decrease in PCSK9 levels over time. © 2015 Stichting European Society for Clinical Investigation Journal Foundation.

  2. Doula Services Within a Healthy Start Program: Increasing Access for an Underserved Population.

    Science.gov (United States)

    Thomas, Mary-Powel; Ammann, Gabriela; Brazier, Ellen; Noyes, Philip; Maybank, Aletha

    2017-12-01

    Women of color in the United States, particularly in high-poverty neighborhoods, experience high rates of poor birth outcomes, including cesarean section, preterm birth, low birthweight, and infant mortality. Doula care has been linked to improvements in many perinatal outcomes, but women of color and low-income women often face barriers in accessing doula support. To address this issue, the New York City Department of Health and Mental Hygiene's Healthy Start Brooklyn introduced the By My Side Birth Support Program in 2010. The goal was to complement other maternal home-visiting programs by providing doula support during labor and birth, along with prenatal and postpartum visits. Between 2010 and 2015, 489 infants were born to women enrolled in the program. Data indicate that By My Side is a promising model of support for Healthy Start projects nationwide. Compared to the project area, program participants had lower rates of preterm birth (6.3 vs. 12.4%, p < 0.001) and low birthweight (6.5 vs. 11.1%, p = 0.001); however, rates of cesarean birth did not differ significantly (33.5 vs. 36.9%, p = 0.122). Further research is needed to explore possible reasons for this finding, and to examine the influence of doula support on birth outcomes among populations with high rates of chronic disease and stressors such as poverty, racism, and exposure to violence. However, feedback from participants indicates that doula support is highly valued and helps give women a voice in consequential childbirth decisions. Available evidence suggests that doula services may be an important component of an effort to address birth inequities.

  3. Semen quality in relation to antioxidant intake in a healthy male population

    DEFF Research Database (Denmark)

    Zareba, Piotr; Colaci, Daniela S; Afeiche, Myriam

    2013-01-01

    To assess the relationship between dietary antioxidant intake and semen quality in young healthy males.......To assess the relationship between dietary antioxidant intake and semen quality in young healthy males....

  4. Assessing grooming behavior of Russian honey bees toward Varroa destructor.

    Science.gov (United States)

    The grooming behavior of Russian bees was compared to Italian bees. Overall, Russian bees had significantly lower numbers of mites than the Italian bees with a mean of 1,937 ± 366 and 5,088 ± 733 mites, respectively. This low mite population in the Russian colonies was probably due to the increased ...

  5. Health effects of protein intake in healthy elderly populations: a systematic literature review

    Directory of Open Access Journals (Sweden)

    Agnes N. Pedersen

    2014-02-01

    Full Text Available The purpose of this systematic review is to assess the evidence behind the dietary requirement of protein and to assess the health effects of varying protein intake in healthy elderly persons in order to evaluate the evidence for an optimal protein intake. The literature search covered year 2000–2011. Prospective cohort, case–control, and intervention studies of a general healthy population in settings similar to the Nordic countries with protein intake from food-based sources were included. Out of a total of 301 abstracts, 152 full papers were identified as potentially relevant. After careful scrutiny, 23 papers were quality graded as A (highest, n=1, B (n=18, or C (n=4. The grade of evidence was classified as convincing, probable, suggestive, or inconclusive. The evidence is assessed as: probable for an estimated average requirement (EAR of 0.66 g good-quality protein/kg body weight (BW/day based on nitrogen balance (N-balance studies and the subsequent recommended dietary allowance (RDA of 0.83 g good-quality protein/kg BW/day representing the minimum dietary protein needs of virtually all healthy elderly persons. Regarding the optimal level of protein related to functional outcomes like maintenance of bone mass, muscle mass, and strength, as well as for morbidity and mortality, the evidence is ranging from suggestive to inconclusive. Results from particularly prospective cohort studies suggest a safe intake of up to at least 1.2–1.5 g protein/kg BW/day or approximately 15–20 E%. Overall, many of the included prospective cohort studies were difficult to fully evaluate since results mainly were obtained by food frequency questionnaires that were flawed by underreported intakes, although some studies were ‘calibrated’ to correct for under- or over-reporting. In conclusion, the evidence is assessed as probable regarding the EAR based on N-balance studies and suggestive to inconclusive regarding an optimal protein intake higher than

  6. STUDY ON SEROPREVALENCE OF MUMPS - SPECIFIC IgG ANTIBODIES IN A HEALTHY POPULATION

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    Milena Karcheva

    2010-09-01

    Full Text Available Mumps is a vaccine preventable viral infection. Its typical clinical manifestations are characterized by pain and swelling of the salivary glands, fever, and fatigue. Often other organs are affected - testes in males after puberty (orchitis, ovaries in women (ooforitis, pancreas (pancreatitis, central nervous system (meningities. The use of specific immune prophylaxis led to a significant success in the fight against mumps, but there are still unresolved issues related to the immunological and epidemiological effectiveness of the vaccines. The disease continues to interest researchers today. The main issues being tackled are related to the conduct of virological, clinical and sero-epidemiological studies in different countries. Objectives of the study is to determine the frequency distribution of mumps-specific IgG antibodies in healthy populations in the region of Pleven, Bulgaria. Methods: a cross-sectional sero - epidemiological representative population - based survey in the area was made. Enzyme immunoassay method was used for an indirect proof of mumps - specific IgG serum antibodies. 410 people were examined at an average age of 25 (1 to 84. Of these, 250 (61 % were women and 160 (39 % - men. Results: Of all test results, the negative were 72 (19 %, the borderline were 12 (3 %, the positive were 182 (44 %, and highly positive were 144 (35 %. The vaccination status showed that 242 (69 % of all surveyed were immunized with a vaccine against mumps. According to the immunization schedule in Bulgaria, 132 (33 % people were immunized with monovaccine during the years - 1 intake, 80 (20 % with trivaccine - 1 intake, and 64 (16 % - 2 doses. Conclusion: We believe that despite the specific immunprophylaxis carried out against mumps decades on end, the necessary level of protection leading to its elimination has not yet been reached.

  7. [Application of Fourier amplitude sensitivity test in Chinese healthy volunteer population pharmacokinetic model of tacrolimus].

    Science.gov (United States)

    Guan, Zheng; Zhang, Guan-min; Ma, Ping; Liu, Li-hong; Zhou, Tian-yan; Lu, Wei

    2010-07-01

    In this study, we evaluated the influence of different variance from each of the parameters on the output of tacrolimus population pharmacokinetic (PopPK) model in Chinese healthy volunteers, using Fourier amplitude sensitivity test (FAST). Besides, we estimated the index of sensitivity within whole course of blood sampling, designed different sampling times, and evaluated the quality of parameters' and the efficiency of prediction. It was observed that besides CL1/F, the index of sensitivity for all of the other four parameters (V1/F, V2/F, CL2/F and k(a)) in tacrolimus PopPK model showed relatively high level and changed fast with the time passing. With the increase of the variance of k(a), its indices of sensitivity increased obviously, associated with significant decrease in sensitivity index for the other parameters, and obvious change in peak time as well. According to the simulation of NONMEM and the comparison among different fitting results, we found that the sampling time points designed according to FAST surpassed the other time points. It suggests that FAST can access the sensitivities of model parameters effectively, and assist the design of clinical sampling times and the construction of PopPK model.

  8. Reference Intervals of Alpha-Fetoprotein and Carcinoembryonic Antigen in the Apparently Healthy Population.

    Science.gov (United States)

    Zhang, Gao-Ming; Guo, Xu-Xiao; Ma, Xiao-Bo; Zhang, Guo-Ming

    2016-12-12

    BACKGROUND The aim of this study was to calculate 95% reference intervals and double-sided limits of serum alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) according to the CLSI EP28-A3 guideline. MATERIAL AND METHODS Serum AFP and CEA values were measured in samples from 26 000 healthy subjects in the Shuyang area receiving general health checkups. The 95% reference intervals and upper limits were calculated by using MedCalc. RESULTS We provided continuous reference intervals from 20 years old to 90 years old for AFP and CEA. The reference intervals were: AFP, 1.31-7.89 ng/ml (males) and 1.01-7.10 ng/ml (females); CEA, 0.51-4.86 ng/ml (males) and 0.35-3.45ng/ml (females). AFP and CEA were significantly positively correlated with age in both males (r=0.196 and r=0.198) and females (r=0.121 and r=0.197). CONCLUSIONS Different races or populations and different detection systems may result in different reference intervals for AFP and CEA. Continuous reference intervals of age changes are more accurate than age groups.

  9. Baseline Antibody Titre against Salmonella enterica in Healthy Population of Mumbai, Maharashtra, India.

    Science.gov (United States)

    Patki, Rucha; Lilani, Sunil; Lanjewar, Dhaneshwar

    2017-01-01

    The aim of this study was to establish a baseline titre for the population of Mumbai, Maharashtra, India. Four hundred healthy blood donors, attending blood donation camps, were screened using a survey questionnaire. Widal tube agglutination test was performed on the diluted sera (with 0.9% normal saline) of blood donors, with final dilution ranging from 1 : 40 to 1 : 320. Out of 400 individuals providing samples, 78 (19.5%) individuals showed antibody titres ≥ 1 : 40 for at least one antigen and 322 (80.5%) showed no agglutination. The baseline antibody titres against O antigen and H antigen of Salmonella enterica serotype Typhi were found to be 1 : 40 and 1 : 80, respectively. Similarly, the baseline antibody titres for the H antigen of Salmonella enterica serotypes Paratyphi A and Paratyphi B were found to be 1 : 40 and 1 : 80, respectively. Thus, it was noted that the diagnostically significant cutoff of antibody titre from acute phase sample was ≥ 1 : 80 for S. Typhi O antigen and titre of ≥ 1 : 160 for both S. Typhi H antigen and S. Paratyphi BH antigen. Antibody titre of ≥ 1 : 80 can be considered significant for S. Paratyphi AH antigen.

  10. Nutrient Status Assessment in Individuals and Populations for Healthy Aging—Statement from an Expert Workshop

    Directory of Open Access Journals (Sweden)

    Szabolcs Péter

    2015-12-01

    Full Text Available A workshop organized by the University Medical Center Groningen addressed various current issues regarding nutrient status of individuals and populations, tools and strategies for its assessment, and opportunities to intervene. The importance of nutrient deficiencies and information on nutrient status for health has been illustrated, in particular for elderly and specific patient groups. The nutrient profile of individuals can be connected to phenotypes, like hypertension or obesity, as well as to socio-economic data. This approach provides information on the relationship between nutrition (nutrient intake and status and health outcomes and, for instance, allows us to use the findings to communicate and advocate a healthy lifestyle. Nutrition is complex: a broader profile of nutrients should be considered rather than focusing solely on a single nutrient. Evaluating food patterns instead of intake of individual nutrients provides better insight into relationships between nutrition and health and disease. This approach would allow us to provide feedback to individuals about their status and ways to improve their nutritional habits. In addition, it would provide tools for scientists and health authorities to update and develop public health recommendations.

  11. Nutrient Status Assessment in Individuals and Populations for Healthy Aging-Statement from an Expert Workshop.

    Science.gov (United States)

    Péter, Szabolcs; Saris, Wim H M; Mathers, John C; Feskens, Edith; Schols, Annemie; Navis, Gerjan; Kuipers, Folkert; Weber, Peter; Eggersdorfer, Manfred

    2015-12-16

    A workshop organized by the University Medical Center Groningen addressed various current issues regarding nutrient status of individuals and populations, tools and strategies for its assessment, and opportunities to intervene. The importance of nutrient deficiencies and information on nutrient status for health has been illustrated, in particular for elderly and specific patient groups. The nutrient profile of individuals can be connected to phenotypes, like hypertension or obesity, as well as to socio-economic data. This approach provides information on the relationship between nutrition (nutrient intake and status) and health outcomes and, for instance, allows us to use the findings to communicate and advocate a healthy lifestyle. Nutrition is complex: a broader profile of nutrients should be considered rather than focusing solely on a single nutrient. Evaluating food patterns instead of intake of individual nutrients provides better insight into relationships between nutrition and health and disease. This approach would allow us to provide feedback to individuals about their status and ways to improve their nutritional habits. In addition, it would provide tools for scientists and health authorities to update and develop public health recommendations.

  12. Internet Use, Depression, and Anxiety in a Healthy Adolescent Population: Prospective Cohort Study.

    Science.gov (United States)

    Thom, Robyn Pauline; Bickham, David S; Rich, Michael

    2018-05-22

    Psychiatric disorders, including conduct disturbances, substance abuse, and affective disorders, emerge in approximately 20% of adolescents. In parallel with the rise in internet use, the prevalence of depression among adolescents has increased. It remains unclear whether and how internet use impacts mental health in adolescents. We assess the association between patterns of internet use and two mental health outcomes (depression and anxiety) in a healthy adolescent population. A total of 126 adolescents between the ages of 12 and 15 years were recruited. Participants reported their typical computer and internet usage patterns. At baseline and one-year follow-up, they completed the Beck Depression Index for primary care (BDI-PC) and the Beck Anxiety Inventory for Primary Care (BAI-PC). Individual linear regressions were completed to determine the association between markers of internet use at baseline and mental health outcomes at one-year follow-up. All models controlled for age, gender, and ethnicity. There was an inverse correlation between minutes spent on a favorite website per visit and BAI-PC score. No association was found between internet use and BDI-PC score. There is no relationship between internet use patterns and depression in adolescents, whereas internet use may mitigate anxiety in adolescents with higher levels of baseline anxiety. ©Robyn Pauline Thom, David S Bickham, Michael Rich. Originally published in JMIR Mental Health (http://mental.jmir.org), 22.05.2018.

  13. Baseline Antibody Titre against Salmonella enterica in Healthy Population of Mumbai, Maharashtra, India

    Directory of Open Access Journals (Sweden)

    Rucha Patki

    2017-01-01

    Full Text Available Objective. The aim of this study was to establish a baseline titre for the population of Mumbai, Maharashtra, India. Method. Four hundred healthy blood donors, attending blood donation camps, were screened using a survey questionnaire. Widal tube agglutination test was performed on the diluted sera (with 0.9% normal saline of blood donors, with final dilution ranging from 1 : 40 to 1 : 320. Results. Out of 400 individuals providing samples, 78 (19.5% individuals showed antibody titres ≥ 1 : 40 for at least one antigen and 322 (80.5% showed no agglutination. The baseline antibody titres against O antigen and H antigen of Salmonella enterica serotype Typhi were found to be 1 : 40 and 1 : 80, respectively. Similarly, the baseline antibody titres for the H antigen of Salmonella enterica serotypes Paratyphi A and Paratyphi B were found to be 1 : 40 and 1 : 80, respectively. Conclusion. Thus, it was noted that the diagnostically significant cutoff of antibody titre from acute phase sample was ≥ 1 : 80 for S. Typhi O antigen and titre of ≥ 1 : 160 for both S. Typhi H antigen and S. Paratyphi BH antigen. Antibody titre of ≥ 1 : 80 can be considered significant for S. Paratyphi AH antigen.

  14. Determination of Mean Glycated Haemoglobin in Healthy Adults of a Local Population.

    Science.gov (United States)

    Nida, Sumbal; Khan, Dilshad Ahmed; Ijaz, Aamir; Khan, Muhammad Qaiser Alam; Aleef, Hira; Abbasi, Maria

    2017-07-01

    To determine the mean hemoglobin HbA1C levels of disease-free adults in a local population and its optimum cutoff for the diagnosis of diabetes. Cross-sectional study. Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi, from January to September 2015. Healthy subjects aged 18 years and above of either gender were recruited from local population. Pregnant ladies and individuals with known diabetes, chronic kidney disease, chronic liver disease, congestive cardiac failure, anemia, hemoglobinopathies, mental illness and individuals on glucocorticoid therapy were excluded. Fasting plasma glucose (FPG) or 2-hour plasma glucose (2-h PG) was analyzed using hexokinase methodology and glycated hemoglobin (Hb A1C) was also analyzed using turbidimetric inhibition immunoassay technique. Receiver operating characteristic (ROC) curves were plotted. Differences among the groups were tested by one-way ANOVA, and p <0.05 was considered statistically significant. Among 558 subjects, 88.8% (496) were normoglycaemic (NG), 5.7% (32) were with impaired glucose fasting (IFG), and 5.4% (30) were diagnosed with diabetes mellitus (DM). A1C was 5.00 ±0.44% in NG and 6.28 ±1.16% in diabetics. FPG in NG was 4.55 ±0.95 mmol/Land in diabetics was 8.28 ±1.78 mmol/L. The optimal HbA1C cutoff value for diagnosis of DM was at 6.05% (AUC 0.827 95% CI 0.732 to 0.923, p ≤0.05 with its sensitivity of 53.3% and specificity of 98.5%. However, HbA1C showed suboptimal sensitivity and specificity for prediabetes. The mean HbAIC and cutoff point for diabetes in the study population is 5.07 ±0.58% and 6.05%, respectively (AUC 0.827, 95% CI: 0.732 to 0.923, p<0.001) with 53.3% sensitivity and 98.5% specificity.

  15. Determination of Mean Glycated Haemoglobin in Healthy Adults of a Local Population

    International Nuclear Information System (INIS)

    Nida, S.; Ijaz, A.; Aleef, H.; Khan, D. A.; Khan, M. Q. A.; Abbasi, M.

    2017-01-01

    Objective: To determine the mean hemoglobin HbA1C levels of disease-free adults in a local population and its optimum cutoff for the diagnosis of diabetes. Study Design: Cross-sectional study. Place and Duration of Study: Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi, from January to September 2015. Methodology: Healthy subjects aged 18 years and above of either gender were recruited from local population. Pregnant ladies and individuals with known diabetes, chronic kidney disease, chronic liver disease, congestive cardiac failure, anemia, hemoglobinopathies, mental illness and individuals on glucocorticoid therapy were excluded. Fasting plasma glucose (FPG) or 2-hour plasma glucose (2-h PG) was analyzed using hexokinase methodology and glycated hemoglobin (Hb A1C) was also analyzed using turbidimetric inhibition immunoassay technique. Receiver operating characteristic (ROC) curves were plotted. Differences among the groups were tested by one-way ANOVA, and p <0.05 was considered statistically significant. Results: Among 558 subjects, 88.8% (496) were normoglycaemic (NG), 5.7% (32) were with impaired glucose fasting (IFG), and 5.4% (30) were diagnosed with diabetes mellitus (DM). A1C was 5.00 0.44% in NG and 6.28 +-1.16% in diabetics. FPG in NG was 4.55 +-0.95 mmol/L and in diabetics was 8.28 1.78 mmol/L. The optimal HbA1C cutoff value for diagnosis of DM was at 6.05% (AUC 0.827 95% CI 0.732 to 0.923, p <=0.05 with its sensitivity of 53.3% and specificity of 98.5%. However, HbA1C showed suboptimal sensitivity and specificity for prediabetes. Conclusion: The mean HbAIC and cutoff point for diabetes in the study population is 5.07 +-0.58% and 6.05%, respectively (AUC 0.827, 95% CI: 0.732 to 0.923, p<0.001) with 53.3% sensitivity and 98.5% specificity. (author)

  16. Population cardiovascular health and urban environments: the Heart Healthy Hoods exploratory study in Madrid, Spain

    Directory of Open Access Journals (Sweden)

    Usama Bilal

    2016-08-01

    Full Text Available Abstract Background Our aim is to conduct an exploratory study to provide an in-depth characterization of a neighborhood’s social and physical environment in relation to cardiovascular health. A mixed-methods approach was used to better understand the food, alcohol, tobacco and physical activity domains of the urban environment. Methods We conducted this study in an area of 16,000 residents in Madrid (Spain. We obtained cardiovascular health and risk factors data from all residents aged 45 and above using Electronic Health Records from the Madrid Primary Health Care System. We used several quantitative audit tools to assess: the type and location of food outlets and healthy food availability; tobacco and alcohol points of sale; walkability of all streets and use of parks and public spaces. We also conducted 11 qualitative interviews with key informants to help understanding the relationships between urban environment and cardiovascular behaviors. We integrated quantitative and qualitative data following a mixed-methods merging approach. Results Electronic Health Records of the entire population of the area showed similar prevalence of risk factors compared to the rest of Madrid/Spain (prevalence of diabetes: 12 %, hypertension: 34 %, dyslipidemia: 32 %, smoking: 10 %, obesity: 20 %. The food environment was very dense, with many small stores (n = 44 and a large food market with 112 stalls. Residents highlighted the importance of these small stores for buying healthy foods. Alcohol and tobacco environments were also very dense (n = 91 and 64, respectively, dominated by bars and restaurants (n = 53 that also acted as food services. Neighbors emphasized the importance of drinking as a socialization mechanism. Public open spaces were mostly used by seniors that remarked the importance of accessibility to these spaces and the availability of destinations to walk to. Conclusion This experience allowed testing and refining

  17. Barriers and Facilitators to Healthy Lifestyle Changes in Minority Ethnic Populations in the UK: a Narrative Review.

    Science.gov (United States)

    Patel, Naina; Ferrer, Harriet Batista; Tyrer, Freya; Wray, Paula; Farooqi, Azhar; Davies, Melanie J; Khunti, Kamlesh

    2017-12-01

    Minority ethnic populations experience a disproportionate burden of health inequalities compared with the rest of the population, including an increased risk of type 2 diabetes (T2DM). The purpose of this narrative review was to explore knowledge and attitudes around diabetes, physical activity and diet and identify barriers and facilitators to healthy lifestyle changes in minority ethnic populations in the UK. The narrative review focused on three key research topics in relation to barriers and facilitators to healthy lifestyle changes in minority adult ethnic populations: (i) knowledge and attitudes about diabetes risk; (ii) current behaviours and knowledge about physical activity and diet; and (iii) barriers and facilitators to living a healthier lifestyle. Nearly all of the studies that we identified reported on South Asian minority ethnic populations; we found very few studies on other minority ethnic populations. Among South Asian communities, there was generally a good understanding of diabetes and its associated risk factors. However, knowledge about the levels of physical activity required to gain health benefits was relatively poor and eating patterns varied. Barriers to healthy lifestyle changes identified included language barriers, prioritising work over physical activity to provide for the family, cultural barriers with regard to serving and eating traditional food, different perceptions of a healthy body weight and fear of racial harassment or abuse when exercising. Additional barriers for South Asian women included expectations to remain in the home, fear for personal safety, lack of same gender venues and concerns over the acceptability of wearing 'western' exercise clothing. Facilitators included concern that weight gain might compromise family/carer responsibilities, desire to be healthy, T2DM diagnosis and exercise classes held in 'safe' environments such as places of worship. Our findings suggest that South Asian communities are less likely to

  18. Assessment of Corneal Biomechanical Properties and Intraocular Pressure in Myopic Spanish Healthy Population

    Directory of Open Access Journals (Sweden)

    María A. del Buey

    2014-01-01

    Full Text Available Purpose. To examine biomechanical parameters of the cornea in myopic eyes and their relationship with the degree of myopia in a western healthy population. Methods. Corneal hysteresis (CH, corneal resistance factor (CRF, Goldmann correlated intraocular pressure (IOP, and corneal compensated IOP (IOPcc were measured using the ocular response analyzer (ORA in 312 eyes of 177 Spanish subjects aged between 20 and 56 years. Refraction was expressed as spherical equivalent (SE, which ranged from 0 to −16.50 diopters (D (mean: −3.88±2.90 D. Subjects were divided into four groups according to their refractive status: group 1 or control group: emmetropia (-0.50≤SE0.05; nevertheless, IOPcc was significantly higher in the moderately myopic (15.47±2.47 mmHg and highly myopic (16.14±2.59 mmHg groups than in the emmetropia (15.15±2.06 mmHg and low myopia groups (14.53±2.37 mmHg. No correlation between age and the measured parameters was found. CH and IOPcc were weakly but significantly correlated with SE (r=0.171, P=0.002 and r=-0.131, P=0.021, resp.. Conclusions. Present study showed only a very weak, but significant, correlation between CH and refractive error, with CH being lower in both moderately and highly myopic eyes than that in the emmetropic and low myopic eyes. These changes in biomechanical properties of the cornea may have an impact on IOP measurement, increasing the risk of glaucoma.

  19. The Distribution of Macular Thickness and Its Determinants in a Healthy Population.

    Science.gov (United States)

    Hashemi, Hassan; Khabazkhoob, Mehdi; Yekta, AbbasAli; Emamian, Mohammad Hassan; Nabovati, Payam; Fotouhi, Akbar

    2017-10-01

    To determine the distribution of macular thickness in a healthy Iranian population aged 45-69 years and its association with certain determinants. All participants underwent optometric examinations including measurement of uncorrected and corrected visual acuity, objective refraction by retinoscopy, and subjective refraction. Subsequently, all participants underwent slit-lamp biomicroscopy followed by fundus examination through direct and indirect ophthalmoscopy, and optical coherence tomography (OCT) imaging under pupil dilation. Mean central macular thickness was 255.4 µm (95% confidence interval, CI, 254.5-256.3 µm), average inner macular thickness was 316.5 µm (95% CI 315.9-317.1 µm), average outer macular thickness was 275.3 µm (95% CI 274.8-275.8 µm), and overall average thickness was 278.6 µm (95% CI 278.1-279.1 µm). A linear multiple regression model showed that all indexes were significantly larger in male participants (p < 0.001). Central macular thickness increased with age (coef = 0.25, p < 0.001) while overall, inner and outer macular thickness decreased with age (coef = -0.18, -0.15, -0.19, respectively, all p < 0.001). Central and inner macular thickness had a positive correlation (coef = 3.8, 2.6, respectively, both p < 0.001) and outer macular thickness had a negative correlation (coef = -1.6, p < 0.001) with axial length. Age, sex, refractive error, axial length, and keratometry were found to be associated with macular thickness. These factors should be taken into account when interpreting macular thickness measurements with spectral-domain OCT.

  20. Population pharmacokinetic analysis of clopidogrel in healthy Jordanian subjects with emphasis optimal sampling strategy.

    Science.gov (United States)

    Yousef, A M; Melhem, M; Xue, B; Arafat, T; Reynolds, D K; Van Wart, S A

    2013-05-01

    Clopidogrel is metabolized primarily into an inactive carboxyl metabolite (clopidogrel-IM) or to a lesser extent an active thiol metabolite. A population pharmacokinetic (PK) model was developed using NONMEM(®) to describe the time course of clopidogrel-IM in plasma and to design a sparse-sampling strategy to predict clopidogrel-IM exposures for use in characterizing anti-platelet activity. Serial blood samples from 76 healthy Jordanian subjects administered a single 75 mg oral dose of clopidogrel were collected and assayed for clopidogrel-IM using reverse phase high performance liquid chromatography. A two-compartment (2-CMT) PK model with first-order absorption and elimination plus an absorption lag-time was evaluated, as well as a variation of this model designed to mimic enterohepatic recycling (EHC). Optimal PK sampling strategies (OSS) were determined using WinPOPT based upon collection of 3-12 post-dose samples. A two-compartment model with EHC provided the best fit and reduced bias in C(max) (median prediction error (PE%) of 9.58% versus 12.2%) relative to the basic two-compartment model, AUC(0-24) was similar for both models (median PE% = 1.39%). The OSS for fitting the two-compartment model with EHC required the collection of seven samples (0.25, 1, 2, 4, 5, 6 and 12 h). Reasonably unbiased and precise exposures were obtained when re-fitting this model to a reduced dataset considering only these sampling times. A two-compartment model considering EHC best characterized the time course of clopidogrel-IM in plasma. Use of the suggested OSS will allow for the collection of fewer PK samples when assessing clopidogrel-IM exposures. Copyright © 2013 John Wiley & Sons, Ltd.

  1. Does vaccination ensure protection? Assessing diphtheria and tetanus antibody levels in a population of healthy children

    Science.gov (United States)

    Gowin, Ewelina; Wysocki, Jacek; Kałużna, Ewelina; Świątek-Kościelna, Bogna; Wysocka-Leszczyńska, Joanna; Michalak, Michał; Januszkiewicz-Lewandowska, Danuta

    2016-01-01

    Abstract Vaccination effectiveness is proven when the disease does not develop after a patient is exposed to the pathogen. In the case of rare diseases, vaccination effectiveness is assessed by monitoring specific antibody levels in the population. Such recurrent analyses allow the evaluation of vaccination programs. The primary schedule of diphtheria and tetanus vaccinations is similar in various countries, with differences mainly in the number and timing of booster doses. The aim of the study was to assess diphtheria and tetanus antibody concentrations in a population of healthy children. Diphtheria and tetanus antibody levels were analyzed in a group of 324 children aged 18 to 180 months. All children were vaccinated in accordance with the Polish vaccination schedule. Specific antibody concentrations greater than 0.1 IU/mL were considered protective against tetanus or diphtheria. Levels above 1.0 were considered to ensure long-term protection. Protective levels of diphtheria antibodies were found in 229 patients (70.46%), and of tetanus in 306 patients (94.15%). Statistically significant differences were found in tetanus antibody levels in different age groups. Mean concentrations and the percentage of children with high tetanus antibody titers increased with age. No similar correlation was found for diphtheria antibodies. High diphtheria antibody levels co-occurred in 72% of the children with high tetanus antibody levels; 95% of the children with low tetanus antibody levels had low levels of diphtheria antibodies. The percentage of children with protective diphtheria antibody levels is lower than that in the case of tetanus antibodies, both in Poland and abroad, but the high proportion of children without diphtheria protection in Poland is an exception. This is all the more puzzling when taking into account that Polish children are administered a total of 5 doses containing a high concentration of diphtheria toxoid, at intervals shorter than 5 years. The

  2. Construction of a short form of the healthy eating behaviour inventory for the Japanese population.

    Science.gov (United States)

    Shimazaki, Takashi; Iio, Misa; Lee, Ying-Hua; Suzuki, Akiko; Konuma, Kayo; Teshima, Yoko; Takenaka, Koji

    2016-09-01

    The present study constructed a short form of the Healthy Eating Behavior Inventory suitable for use in the Japanese culture (HEBI-J) and confirmed the scale's preliminary reliability and validity. In Study 1, Japanese adults (N=75) completed a free-response questionnaire about healthy eating behaviours. Thematic analysis was used to identify three factors-balance, pattern, and restriction-associated with healthy eating behaviours and 12 items related to these healthy eating behaviours. In Study 2, Japanese office workers (N=784) completed two questionnaires regarding 12 items of healthy eating behaviours and the dietary stages of change. Confirmatory factor analysis demonstrated that the three-factor model was appropriate (GFI=.94, AGFI=.90, CFI=.90, RMSEA=.08, SRMR=.53). Reliability was confirmed by alpha coefficients and the Spearman-Brown formula. Concurrent validity was confirmed by the relationship between the healthy eating stages. This study demonstrated the preliminary reliability and validity of the HEBI-J. Copyright © 2015 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

  3. Does a healthy lifestyle behaviour influence the prognosis of low back pain among men and women in a general population? A population-based cohort study.

    Science.gov (United States)

    Bohman, Tony; Alfredsson, Lars; Jensen, Irene; Hallqvist, Johan; Vingård, Eva; Skillgate, Eva

    2014-12-30

    To study the influence of healthy lifestyle behaviour on the prognosis of occasional low back pain among men and women in a general population. Cohort study with a 4-year follow-up. General population in Stockholm County, Sweden. The study sample comprised 3938 men and 5056 women aged 18-84 from the Stockholm Public Health Cohort reporting occasional low back pain in the baseline questionnaire 2006. Lifestyle factors and potential confounders were assessed at baseline. The lifestyle factors smoking habits, alcohol consumption, leisure physical activity and consumption of fruit and vegetables were dichotomised using recommendations for a health-enhancing lifestyle and combined to form the exposure variable 'healthy lifestyle behaviour'. The exposure was categorised into five levels according to the number of healthy lifestyle factors met. The follow-up questionnaire in 2010 gave information about the outcome, long duration troublesome low back pain. Crude and adjusted binomial regression models were applied to estimate the association between the exposure and the outcome analysing men and women separately. The risk of developing long duration troublesome low back pain among women with occasional low back pain decreased with increasing healthy lifestyle behaviour (trend test: p=0.006). 21% (28/131) among women with no healthy lifestyle factor (reference) experienced the outcome compared to 9% (36/420) among women with all four factors. Compared to the reference group, the risk was reduced by 35% (RR 0.65, 95% CI 0.44 to 0.96) for women with one healthy lifestyle factor and 52% (RR 0.48, 95% CI 0.31 to 0.77) for women with all four healthy lifestyle factors. There were no clear associations found among men. Healthy lifestyle behaviour seems to decrease the risk of developing long duration troublesome low back pain among women with occasional low back pain and may be recommended to improve the prognosis. Published by the BMJ Publishing Group Limited. For permission to

  4. ECG-derived Cheyne-Stokes respiration and periodic breathing in healthy and hospitalized populations.

    Science.gov (United States)

    Tinoco, Adelita; Drew, Barbara J; Hu, Xiao; Mortara, David; Cooper, Bruce A; Pelter, Michele M

    2017-11-01

    Cheyne-Stokes respiration (CSR) has been investigated primarily in outpatients with heart failure. In this study we compare CSR and periodic breathing (PB) between healthy and cardiac groups. We compared CSR and PB, measured during 24 hr of continuous 12-lead electrocardiographic (ECG) Holter recording, in a group of 90 hospitalized patients presenting to the emergency department with symptoms suggestive of acute coronary syndrome (ACS) to a group of 100 healthy ambulatory participants. We also examined CSR and PB in the 90 patients presenting with ACS symptoms, divided into a group of 39 (43%) with confirmed ACS, and 51 (57%) with a cardiac diagnosis but non-ACS. SuperECG software was used to derive respiration and then calculate CSR and PB episodes from the ECG Holter data. Regression analyses were used to analyze the data. We hypothesized SuperECG software would differentiate between the groups by detecting less CSR and PB in the healthy group than the group of patients presenting to the emergency department with ACS symptoms. Hospitalized patients with suspected ACS had 7.3 times more CSR episodes and 1.6 times more PB episodes than healthy ambulatory participants. Patients with confirmed ACS had 6.0 times more CSR episodes and 1.3 times more PB episodes than cardiac non-ACS patients. Continuous 12-lead ECG derived CSR and PB appear to differentiate between healthy participants and hospitalized patients. © 2017 Wiley Periodicals, Inc.

  5. Survey of HFE Gene C282Y Mutation in Turkish Beta-Thalassemia Patients and Healthy Population: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Selma Ünal

    2014-09-01

    Full Text Available OBJECTIVE: This study was planned in order to determine the effect of C282Y mutation in development of secondary hemochromatosis in beta-thalassemia patients and to determine the prevalence and allele frequency of this mutation in a healthy control group. METHODS: Eighty-seven children and young adults (46 males and 41 females; mean age: 15.6±6.1 years, range: 3-30 years with beta-thalassemia major (BTM and 13 beta-thalassemia intermedia (BTI patients (6 males and 7 females; mean age: 19.6±3.5 years, range: 13-26 years were included in the study. The control group comprised 100 healthy blood donors. RESULTS: Neither heterozygous nor homozygous HFE gene C282Y mutation was detected in patients with BTM or BTI, or in control group. CONCLUSION: The C282Y mutation, which is supposed to be responsible for the majority of hereditary hemochromatosis, was not found to have a role in the development of hemochromatosis in beta-thalassemia patients and was not detected in a healthy Turkish population. However, research on larger cohorts of individuals is required in order to determine the exact prevalence of the HFE gene mutation in Turkish populations from diverse ethnic origins and whether it would have an impact on iron loading in thalassemic populations.

  6. Food and water security issues in Russia II: Water security in general population of Russian Arctic, Siberia and Far East, 2000–2011

    Directory of Open Access Journals (Sweden)

    Alexey A. Dudarev

    2013-12-01

    Full Text Available Background . Poor state of water supply systems, shortage of water purification facilities and disinfection systems, low quality of drinking water generally in Russia and particularly in the regions of the Russian Arctic, Siberia and Far East have been defined in the literature. However, no standard protocol of water security assessment has been used in the majority of studies. Study design and methods . Uniform water security indicators collected from Russian official statistical sources for the period 2000–2011 were used for comparison for 18 selected regions in the Russian Arctic, Siberia and Far East. The following indicators of water security were analyzed: water consumption, chemical and biological contamination of water reservoirs of Categories I and II of water sources (centralized – underground and surface, and non-centralized and of drinking water. Results . Water consumption in selected regions fluctuated from 125 to 340 L/person/day. Centralized water sources (both underground and surface sources are highly contaminated by chemicals (up to 40–80% and biological agents (up to 55% in some regions, mainly due to surface water sources. Underground water sources show relatively low levels of biological contamination, while chemical contamination is high due to additional water contamination during water treatment and transportation in pipelines. Non-centralized water sources are highly contaminated (both chemically and biologically in 32–90% of samples analyzed. Very high levels of chemical contamination of drinking water (up to 51% were detected in many regions, mainly in the north-western part of the Russian Arctic. Biological contamination of drinking water was generally much lower (2.5–12% everywhere except Evenki AO (27%, and general and thermotolerant coliform bacteria predominated in drinking water samples from all regions (up to 17.5 and 12.5%, correspondingly. The presence of other agents was much lower: Coliphages

  7. Food and water security issues in Russia II: Water security in general population of Russian Arctic, Siberia and Far East, 2000–2011

    Science.gov (United States)

    Dudarev, Alexey A.; Dushkina, Eugenia V.; Sladkova, Yuliya N.; Alloyarov, Pavel R.; Chupakhin, Valery S.; Dorofeyev, Vitaliy M.; Kolesnikova, Tatjana A.; Fridman, Kirill B.; Evengard, Birgitta; Nilsson, Lena M.

    2013-01-01

    Background Poor state of water supply systems, shortage of water purification facilities and disinfection systems, low quality of drinking water generally in Russia and particularly in the regions of the Russian Arctic, Siberia and Far East have been defined in the literature. However, no standard protocol of water security assessment has been used in the majority of studies. Study design and methods Uniform water security indicators collected from Russian official statistical sources for the period 2000–2011 were used for comparison for 18 selected regions in the Russian Arctic, Siberia and Far East. The following indicators of water security were analyzed: water consumption, chemical and biological contamination of water reservoirs of Categories I and II of water sources (centralized – underground and surface, and non-centralized) and of drinking water. Results Water consumption in selected regions fluctuated from 125 to 340 L/person/day. Centralized water sources (both underground and surface sources) are highly contaminated by chemicals (up to 40–80%) and biological agents (up to 55% in some regions), mainly due to surface water sources. Underground water sources show relatively low levels of biological contamination, while chemical contamination is high due to additional water contamination during water treatment and transportation in pipelines. Non-centralized water sources are highly contaminated (both chemically and biologically) in 32–90% of samples analyzed. Very high levels of chemical contamination of drinking water (up to 51%) were detected in many regions, mainly in the north-western part of the Russian Arctic. Biological contamination of drinking water was generally much lower (2.5–12%) everywhere except Evenki AO (27%), and general and thermotolerant coliform bacteria predominated in drinking water samples from all regions (up to 17.5 and 12.5%, correspondingly). The presence of other agents was much lower: Coliphages – 0.2–2

  8. Food and water security issues in Russia II: water security in general population of Russian Arctic, Siberia and Far East, 2000-2011.

    Science.gov (United States)

    Dudarev, Alexey A; Dushkina, Eugenia V; Sladkova, Yuliya N; Alloyarov, Pavel R; Chupakhin, Valery S; Dorofeyev, Vitaliy M; Kolesnikova, Tatjana A; Fridman, Kirill B; Evengard, Birgitta; Nilsson, Lena M

    2013-01-01

    Poor state of water supply systems, shortage of water purification facilities and disinfection systems, low quality of drinking water generally in Russia and particularly in the regions of the Russian Arctic, Siberia and Far East have been defined in the literature. However, no standard protocol of water security assessment has been used in the majority of studies. Uniform water security indicators collected from Russian official statistical sources for the period 2000-2011 were used for comparison for 18 selected regions in the Russian Arctic, Siberia and Far East. The following indicators of water security were analyzed: water consumption, chemical and biological contamination of water reservoirs of Categories I and II of water sources (centralized--underground and surface, and non-centralized) and of drinking water. Water consumption in selected regions fluctuated from 125 to 340 L/person/day. Centralized water sources (both underground and surface sources) are highly contaminated by chemicals (up to 40-80%) and biological agents (up to 55% in some regions), mainly due to surface water sources. Underground water sources show relatively low levels of biological contamination, while chemical contamination is high due to additional water contamination during water treatment and transportation in pipelines. Non-centralized water sources are highly contaminated (both chemically and biologically) in 32-90% of samples analyzed. Very high levels of chemical contamination of drinking water (up to 51%) were detected in many regions, mainly in the north-western part of the Russian Arctic. Biological contamination of drinking water was generally much lower (2.5-12%) everywhere except Evenki AO (27%), and general and thermotolerant coliform bacteria predominated in drinking water samples from all regions (up to 17.5 and 12.5%, correspondingly). The presence of other agents was much lower: Coliphages--0.2-2.7%, Clostridia spores, Giardia cysts, pathogenic bacteria, Rotavirus

  9. Helicobacter Pylori Associated Antral Gastritis in Peptic Ulcer Disease Patients and Normal Healthy Population of Kashmir, India

    Science.gov (United States)

    Malik, G. M.; Bhat, M. Youssuf; rather, Ab. Rashid; Basu, Javaid Ahmad; Qureshi, Khursheed Ahmad

    1998-01-01

    Aim: To study the association of Helicobacter pylori infection with chronic antral gastritis in peptic ulcer disease patients and healthy population of Kashmir. Methods: 50 peptic ulcer patients (duodenal ulcer = 46, gastric ulcer = 2 and combined duodenal and gastric ulcer = 2) and 30 asymptomatic healthy volunteers were included in this study. Peptic ulcer was diagnosed on endoscopic examination. 4–6 punch biopsies were taken from gastric antrum in all the individuals and in case of gastric ulcer an additional biopsy was taken from the edge of the ulcer to exclude its malignant nature. Helicobacter pylori (H. pylori) organism was diagnosed using three different test methods, viz. Histology (using Giemsa Stain), Microbiology (Gram Stain) and Biochemistry (using one minute Endoscopy Room Test). Histological diagnosis of H. pylori was taken as the “gold standard” for the presence of H. pylori organism. Histological diagnosis of gastritis was made using Hematoxylin and Eosin Stain and the gastritis was classified as active chronic gastritis and superficial chronic gastritis. Results: Out of 30 peptic ulcer disease patients with associated antral gastritis, 27 (90%) were positive for H. pylori on histological examination (13 superficial chronic gastritis and 14 active chronic gastritis) whereas out of 8 healthy volunteers with histological evidence of chronic antral gastritis, H. pylori was observed in 7 individuals (87.50%) (4 active chronic gastritis and 3 superficial chronic gastritis). Conclusion: A highly significant association between H. pylori infection with chronic antral gastritis both in peptic ulcer disease patients and healthy volunteers of Kashmir was found in this study. Association between H. pylori infection and chronic gastritis was 90% in peptic ulcer group and 87.50% in healthy population (P<0.005). PMID:18493464

  10. Effect of short-term consumption bitter apricot seeds on the body composition in healthy population

    Directory of Open Access Journals (Sweden)

    Jana Kopčeková

    2017-01-01

    Full Text Available The distribution of fat in different areas of the body is important since accumulation of fat within the abdominal cavity represents a much more severe cardiovascular risk than accumulation in subcutaneous adipose tissues. Apricot seeds contain a wide variety of bioactive compounds and that consumption can decrease blood pressure and total blood cholesterol levels, fight oxidative stress and maintain body weight. The aim of the study was to analyse body composition: body fat mass (BFM, fat free mass (FFM, skeletal muscle mass (SMM, body fat percentage (%BFM, visceral fat area (VFA, total body water (TBW - intracellular water (ICW and extracellular water (ECW and to evaluate the changes that occur after 6-weeks consumption of bitter apricot seeds. The study group finally consisted of 34 healthy adults volunteers (21 females and 13 males. Volunteers were recruited from the general population of Slovakia. Respondents were 23 - 65 years old, where the average age of women was 40.65 ±11.31 years and the average age of men was 36.91 ±9.98 years. All participants were asked to consume 60 mg.kg-1 of body weight of bitter apricot seeds daily during 6 weeks. Body composition was diagnosed by multi-frequency bioelectrical impedance analysis (MFBIA by InBody 720 (Biospace Co., Korea, which measures the total impedance at frequencies of 1, 5, 50, 100, 500, 1000 kHz. At baseline mean body weight was 85.78 ±14.66 and 62.84 ±12.19 kg in the male and female participants, respectively. After 6 weeks of consumation we observed non-significant decreasing of mean body weight. The mean BFM was 19.25 ±8.81 kg in the male group and 19.47 ±7.21 kg in the female group. After six weeks, BFM decreased non-significantly (on average 0.5 kg in both groups. The mean FFM at baseline was 43.37 ±5.98 and 66.54 ±7.98 kg in the female and male participants, respectively. The statistical analysis confirmed that the increase of FFM (43.37 ±5.98 kg to 43.56 ±5.80 kg in the

  11. Prevalence of Taxa of Pasteurellaceae Among Populations of Healthy Captive Psittacine Birds

    DEFF Research Database (Denmark)

    Bisgaard, M.; Xin, Di; Bertelsen, M. F.

    2017-01-01

    Sixty-two strains of Pasteurellaceae-like bacteria were isolated from the tracheas of 87 clinically healthy psittacine birds in two Danish zoos. The isolates were identified by a combination of rpoB and 16S rRNA gene sequencing and by matrix-assisted laser desorption–ionization time of flight. Tw...

  12. Health effects of protein intake in healthy elderly populations: a systematic literature review

    DEFF Research Database (Denmark)

    Pedersen, Agnes N.; Cederholm, Tommy

    2014-01-01

    The purpose of this systematic review is to assess the evidence behind the dietary requirement of protein and to assess the health effects of varying protein intake in healthy elderly persons in order to evaluate the evidence for an optimal protein intake. The literature search covered year 2000-...

  13. Food and water security issues in Russia I: food security in the general population of the Russian Arctic, Siberia and the Far East, 2000-2011.

    Science.gov (United States)

    Dudarev, Alexey A; Alloyarov, Pavel R; Chupakhin, Valery S; Dushkina, Eugenia V; Sladkova, Yuliya N; Dorofeyev, Vitaliy M; Kolesnikova, Tatijana A; Fridman, Kirill B; Nilsson, Lena Maria; Evengård, Birgitta

    2013-01-01

    Problems related to food security in Russian Arctic (dietary imbalance, predominance of carbohydrates, shortage of milk products, vegetables and fruits, deficit of vitamins and microelements, chemical, infectious and parasitic food contamination) have been defined in the literature. But no standard protocol of food security assessment has been used in the majority of studies. Our aim was to obtain food security indicators, identified within an Arctic collaboration, for selected regions of the Russian Arctic, Siberia and the Far East, and to compare food safety in these territories. In 18 regions of the Russian Arctic, Siberia and the Far East, the following indicators of food security were analyzed: food costs, food consumption, and chemical and biological food contamination for the period 2000-2011. Food costs in the regions are high, comprising 23-43% of household income. Only 4 out of 10 food groups (fish products, cereals, sugar, plant oil) are consumed in sufficient amounts. The consumption of milk products, eggs, vegetables, potatoes, fruits (and berries) is severely low in a majority of the selected regions. There are high levels of biological contamination of food in many regions. The biological and chemical contamination situation is alarming, especially in Chukotka. Only 7 food pollutants are under regular control; among pesticides, only DDT. Evenki AO and Magadan Oblast have reached peak values in food contaminants compared with other regions. Mercury in local fish has not been analyzed in the majority of the regions. In 3 regions, no monitoring of DDT occurs. Aflatoxins have not been analyzed in 5 regions. Nitrates had the highest percentage in excess of the hygienic threshold in all regions. Excesses of other pollutants in different regions were episodic and as a rule not high. Improvement of the food supply and food accessibility in the regions of the Russian Arctic, Siberia and the Far East is of utmost importance. Both quantitative and qualitative

  14. Reference intervals for stone risk factors in 24-h urine among healthy adults of the Han population in China.

    Science.gov (United States)

    Mai, Zanlin; Li, Xiaoxia; Cui, Zelin; Wu, Wenqi; Liu, Yongda; Ou, Lili; Liang, Yueping; Zhao, Zhijian; Liu, Yang; Mai, Xing; Zhu, Wei; Zhang, Tao; Cai, Chao; Yang, Houmeng; Zeng, Guohua

    2018-03-28

    The aim of the study was to establish reference intervals for 24-h urinary stone risk factors in the healthy Chinese Han population. From May 2013 to July 2014, we collected and analyzed 24-h urine samples from healthy adult Han population during a cross-sectional study across China. The protocol for analysis of 24-h urine included volume, pH, oxalate, citrate, sodium, potassium, chloride, calcium, phosphorous, creatinine, urate, magnesium, the ion activity products of calcium oxalate (AP(CaOx) indexs) and calcium phosphate (AP(CaP) indexs). We calculated the reference intervals according to the Clinical and Laboratory Standards Institute (CLSI) 2008 guidelines and compared them with those recorded in other studies. A total of 132 male and 123 female healthy subjects with a mean (SD, range) age of 52.4 (15.2, 19-89) years were eligible in the final analysis. Men had higher 24-h excretion of creatinine, calcium, urate and phosphorus and lower levels of citrate, magnesium, chloride, sodium and potassium than women. AP(CaOx) indexs and AP(CaP) indexs were significantly higher among men than women. When urinary findings were compared with the reference intervals, most of our data showed a high abnormality rate, especially for creatinine, calcium, citrate, magnesium, chloride, sodium and potassium. The present study revealed the normal metabolic status for stone risk factors of the Chinese Han population. It is therefore necessary for each country or region to define their own reference intervals for comparison of stone risk factors between patients and healthy subjects.

  15. Significant association of periodontal disease with anti-citrullinated peptide antibody in a Japanese healthy population - The Nagahama study.

    Science.gov (United States)

    Terao, Chikashi; Asai, Keita; Hashimoto, Motomu; Yamazaki, Toru; Ohmura, Koichiro; Yamaguchi, Akihiko; Takahashi, Katsu; Takei, Noriko; Ishii, Takanori; Kawaguchi, Takahisa; Tabara, Yasuharu; Takahashi, Meiko; Nakayama, Takeo; Kosugi, Shinji; Sekine, Akihiro; Fujii, Takao; Yamada, Ryo; Mimori, Tsuneyo; Matsuda, Fumihiko; Bessho, Kazuhisa

    2015-05-01

    Anti-citrullinated peptide antibody (ACPA) is a highly specific autoantibody to rheumatoid arthritis (RA). Recent studies have revealed that periodontal disease (PD) is closely associated with RA and production of ACPA in RA. Analyses of associations between PD and ACPA production in a healthy population may deepen our understandings. Here, we analyzed a total of 9554 adult healthy subjects. ACPA and IgM-rheumatoid factor (RF) was quantified and PD status was evaluated using the number of missing teeth (MT), the Community Periodontal Index (CPI) and Loss of Attachment (LA) for these subjects. PD status was analyzed for its association with the positivity and categorical levels of ACPA and RF conditioned for covariates which were shown to be associated with PD, ACPA or RF. As a result, all of MT, CPI and LA showed suggestive or significant associations with positivity (p = 0.024, 0.0042 and 0.037, respectively) and levels of ACPA (p ≤ 0.00031), but none of the PD parameters were associated with those of RF. These association patterns were also observed when we analyzed 6206 non-smokers of the participants. The significant associations between PD parameters and positivity and levels of ACPA in healthy population support the fundamental involvement of PD with ACPA production. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Radiation-hygienic passportization and USIDC-information basis for management decision making for radiation safety of the population of the Russian Federation. Report 1. Main achievements and challenges to improve

    Directory of Open Access Journals (Sweden)

    G. G. Onishchenko

    2017-01-01

    Full Text Available The article analyzes 20-year experience in radiation-hygienic certification in the Russian Federation and the Unified System of Individual Dose Control of the citizens. Radiation-hygienic passport is an objective and accessible information about the characteristics of all sources of ionizing radiation (man-made, medical, natural and the radiation doses of the population caused by them on the territory of the whole country and in particular subjects of the Russian Federation. Radiation-hygienic passportization and the Unified System of Individual Dose Control of the citizens are currently covering all enterprises that carry out handling with technogenic sources of radiation, supervised by the Rospotrebnadzor and the Federal Medical and Biological Agency of the Russian Federation, and subordinated to the Ministry of Internal Affairs, the Ministry of Defence, the Federal Security Service, the Federal Service for the Execution of Punishments and the Presidential Executive Office. The Interregional Radiation Safety Centers play an important role in improving the effectiveness of organizational work, filling the passports with objective information. The Centers were created by the order of the Rospotrebnadzor in 2007, capable of performing all types of radiation control necessary for the qualitative filling of radiation and hygienic passports, including for the attached territories. The work on the certification of radiation facilities and territories has made it possible to establish the levels and exposure structure of the country’s population from all major sources of ionizing radiation and to identify population groups for which doses due to the natural sources exceed 5 and 10 mSv/year; control and accounting of radiation doses to patients have been introduced in the practice of medical institutions. The work is underway to optimize the structure of medical radiology research; the system of establishing reference levels of medical exposure has

  17. Vitamin-D receptor (VDR) gene polymorphisms (Taq-I & Apa-I) in Syrian healthy population.

    Science.gov (United States)

    Haddad, Shaden

    2014-12-01

    The vitamin D endocrine system regulates bone metabolism and calcium homeostasis as well as cellular proliferation and differentiation. Vitamin D receptor (VDR) mediates Vit-D activity, thus VDR gene polymorphisms may correlate with different diseases. This study aimed to determine the distribution of VDR gene (Taq-I and Apa-I) polymorphisms using a RFLP in unrelated normal healthy individuals of Syrian population. Allelic frequencies were 65% vs 35% and 66% vs 34% for T vs t and A vs a alleles, respectively. Genotype distribution was 36%, 58% and 6% for TT, Tt and tt and 42%, 47% and 10% for AA, Aa and aa, respectively. These results demonstrate that the frequency and distribution of the VDR polymorphisms in Syrian population are different from other populations worldwide.

  18. Doula Services Within a Healthy Start Program: Increasing Access for an Underserved Population

    OpenAIRE

    Thomas, Mary-Powel; Ammann, Gabriela; Brazier, Ellen; Noyes, Philip; Maybank, Aletha

    2017-01-01

    Purpose Women of color in the United States, particularly in high-poverty neighborhoods, experience high rates of poor birth outcomes, including cesarean section, preterm birth, low birthweight, and infant mortality. Doula care has been linked to improvements in many perinatal outcomes, but women of color and low-income women often face barriers in accessing doula support. Description To address this issue, the New York City Department of Health and Mental Hygiene’s Healthy Start Brooklyn int...

  19. Quantitative nailfold capillaroscopy findings in a population with connective tissue disease and in normal healthy controls.

    Science.gov (United States)

    Kabasakal, Y; Elvins, D M; Ring, E F; McHugh, N J

    1996-01-01

    OBJECTIVE: To describe and quantify the morphological characteristics of nailfold capillaries that distinguish different forms of connective tissue disease from healthy controls. METHODS: A CCD video microscope with fibreoptic illumination and PC based image processing was used to visualise nailfold capillaries and to quantify findings in 23 patients with systemic sclerosis (SSc), 22 patients with systemic lupus erythematosus (SLE), 21 patients with undifferentiated connective tissue disease (UCTD), and 38 healthy controls. RESULTS: Capillary density was reduced in SSc (5.2 (SD 1.3) capillaries/mm) compared with other patient groups and controls. The average number of enlarged capillaries/finger was high in all disease groups (5.5-6.6) compared with controls (2). However, giant capillaries were most frequent in SSc (43%) and were not present in controls. Mild and moderate avascular areas were present in all groups (35%-68%), but severe avascularity was most frequent in SSc (44%) compared with other patients (18%-19%) and controls (0%). The greatest frequency of extensive haemorrhage was in SSc (35%). CONCLUSIONS: There is a range of abnormal capillary findings in patients with connective tissue disease and healthy controls. However, certain abnormalities such as a reduced number of capillaries, severe avascularity, giant capillaries, and haemorrhage are most commonly associated with SSc. Videomicroscopy with image processing offers many technical advantages that can be exploited in further studies of nailfold capillaries. Images PMID:8774177

  20. Fluid intake and voiding; habits and health knowledge in a young, healthy population.

    Science.gov (United States)

    Das, Rebekah N; Grimmer-Somers, Karen A

    2012-01-01

    Health professionals commonly advise patients with incontinence and other lower urinary tract symptoms about modifiable contributing factors such as drinking and voiding habits. Poor drinking and voiding habits may begin early in life, before symptoms emerge. However, little is known about the habits and knowledge young people have regarding healthy drinking and voiding behaviors. This research aimed to assess the habits and health knowledge of young people regarding fluid intake and voiding. A questionnaire was used to assess the drinking and voiding behaviors of first year university students and their knowledge about healthy fluid intake and voiding. The average daily fluid intake was >2 L/day for both genders. Poor drinking and voiding habits (such as high consumption of caffeinated drinks and alcohol, or nocturia) were common. Widely reported myths about the benefits of a high fluid intake were commonly believed. More informed public education regarding healthy fluid intake, and drinking and voiding habits, is required as part of the effort to reduce the development of lower urinary tract symptoms, including incontinence.

  1. Common meanings of good and bad sleep in a healthy population sample.

    Science.gov (United States)

    Dickerson, Suzanne S; Klingman, Karen J; Jungquist, Carla R

    2016-09-01

    The study's purpose was to understand the common meanings and shared practices related to good and bad sleep from narratives of a sample of healthy participants. Interpretive phenomenology was the approach to analyze narratives of the participants' everyday experiences with sleep. Participants were interviewed and asked to describe typical good and bad nights' sleep, what contributes to their sleep experience, and the importance of sleep in their lives. Team interpretations of narratives identified common themes by consensus. Medium sized city in New York State (upper west region). A sample of 30 healthy participants were from a parent study (n=300) on testing the sleep questions from the Behavioral Risk Factor Surveillance System from the Centers for Disease Control and Prevention. Interpretations of good and bad sleep. Participants described similar experiences of good and bad sleep often directly related to their ability to schedule time to sleep, fall asleep, and maintain sleep. Worrying about life stresses and interruptions prevented participants from falling asleep and staying asleep. Yet, based on current life priorities (socializers, family work focused, and optimum health seekers), they had differing values related to seeking sleep opportunities and strategizing to overcome challenges. The participants' priorities reflected the context of their main concerns and stresses in life that influenced the importance given to promoting sleep opportunities. Public health messages tailored to life priorities could be developed to promote healthy sleep practices. Copyright © 2016 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.

  2. How healthy are the rhinoceros populations in the Hluhluwe-iMfolosi Park?

    Directory of Open Access Journals (Sweden)

    LP Fatti

    2013-06-01

    Full Text Available Arising from a study conducted in the Hluhluwe-iMfolosi Park by the author in the late nineties, a method is proposed for improving the estimate of the size of a wildlife population by combining data from current and past surveys. The method is based on a simple state space model which takes into account the (unknown birth rate in the population and all known losses (mortalities and relocations and gains (introductions in the population between successive surveys, as well as the errors in the survey estimates. The method is applied to the White- and Black Rhinoceros populations in the Hluhluwe-iMfolosi Park and tentative conclusions are drawn on the health of these two populations.

  3. The Russian gas industry

    International Nuclear Information System (INIS)

    1997-01-01

    The Russian Federation holds the world's largest proven natural gas reserves, and produces more natural gas than any other nation. Russian exports of gas to Europe and the other nations of the Commonwealth of Independent States (CIS) have a significant impact on natural gas markets throughout Europe and Asia. The aim of this three part study is to inform the international energy and investment community about the current status of the Russian gas industry and the prospects for its future development through 2010. It is also intended to provide an opportunity for the appropriate authorities in the Russian Federation to assess the needs of the industry and to consider areas for possible collaboration with the international investment community and international organizations in a rapidly changing economic and business environment. The study was prepared by the Energy Branch of the United Nations Department for Development Support and Management Services (UN/DDSMS). It was financed by the United Nations Development Programme (UNDP). Part I describes Russian gas reserves and potential resources, and overviews the country's gas producing, pipeline and distribution industries. Additionally, it summarizes the markets for Russian natural gas including domestic and external markets. It discusses the primary economics and potential factors that currently impact the Russian gas industry during the Federation's transition toward a market economy. Part II highlights possible directions for the development of the Russian gas resource base, including upstream gas production and downstream marketing in five-, ten- and fifteen-year time frames. It projects export opportunities for Russian Federation gas and evaluates the options for shaping regional and international markets. Part III addresses the legal and regulatory framework and fiscal regime of the Russian gas industry. It also reviews the major investment requirements and the equipment and training needs of the Russian gas

  4. Nutrient Status Assessment in Individuals and Populations for Healthy Aging-Statement from an Expert Workshop

    NARCIS (Netherlands)

    Peter, Szabolcs; Saris, Wim H. M.; Mathers, John C.; Feskens, Edith; Schols, Annemie; Navis, Gerjan; Kuipers, Folkert; Weber, Peter; Eggersdorfer, Manfred

    2015-01-01

    A workshop organized by the University Medical Center Groningen addressed various current issues regarding nutrient status of individuals and populations, tools and strategies for its assessment, and opportunities to intervene. The importance of nutrient deficiencies and information on nutrient

  5. Nutriënt status assessment in individuals and populations for healthy aging

    NARCIS (Netherlands)

    Szabolcs, P.; Saris, W.H.M.; Mathers, J.C.; Feskens, E.J.M.; Schols, A.M.; Navis, G.; Kuipers, F.; Weber, P.; Eggersdorfer, Manfred

    2015-01-01

    A workshop organized by the University Medical Center Groningen addressed various current issues regarding nutrient status of individuals and populations, tools and strategies for its assessment, and opportunities to intervene. The importance of nutrient deficiencies and information on nutrient

  6. Metabolically healthy obesity and risk of leukoaraiosis; a population based cross-sectional study.

    Science.gov (United States)

    Okamura, Takuro; Hashimoto, Yoshitaka; Hamaguchi, Masahide; Ohbora, Akihiro; Kojima, Takao; Fukui, Michiaki

    2018-04-10

    Metabolically healthy obese (MHO) individual is known to be defended from the metabolic complications of obesity. Leukoaraiosis, which is commonly detected on brain magnetic resonance imaging (MRI), is now recognized as a risk of stroke, dementia and death. However, the association between MHO and the prevalence of leukoaraiosis is unclear. In this cross-sectional study of 796 participants who received a medical examination program, we investigated the association between MHO and the prevalence of leukoaraiosis. We used common clinical markers for definition of metabolic healthy status: blood pressure, fasting plasma glucose, triglycerides and high-density lipoprotein cholesterol concentrations. Obesity was defined by body mass index ≥25.0 kg/m 2 . We diagnosed leukoaraiosis by fluid-attenuated inversion recovery without hypointensity on T1-weighted images or the presence of a hyperintensity on T2-weighted images. The crude prevalence proportion of leukoaraiosis was 44.5% (case/n = 171/384) in metabolically healthy nonobese (MHNO) individual, 46.3% (44/95) in MHO individual, 62.3% (114/183) in metabolically unhealthy nonobese (MUNO) individual or 56.6% (77/136) in MUO individual. The odds ratios of prevalence of leukoaraiosis were 1.19 (95% CI 0.74-1.90, p = 0.471) for MHO, 1.79 (1.22-2.62, p = 0.003) for MUNO and 1.56 (1.03-2.37, p = 0.037) for MUO individuals after adjusting for sex, age, smoking statues, habit of exercise and alcohol, compared with MHNO individual. We revealed that MHO individuals were not related with the higher risk of leukoaraiosis, whereas MUNO and MUO individuals were.

  7. [Prevalence of healthy oral habits in the child population resident in Spain].

    Science.gov (United States)

    Lapresa, L Barriuso; Barbero, B Sanz; Arizaleta, L Hernando

    2012-03-01

    Oral health is integral to children's health. To achieve this, it is essential establishing healthy habits early on them, such as regular check-ups, proper and frequent tooth brushing and a non-cariogenic diet. Prevalence of these habits are investigated in Spanish children by age group (pre-school: 2-5 years and school: 6-15 years) and by maternal educational level. A descriptive cross-sectional study was conducted, based on the last Spanish National Health Survey (2006). A representative sample of 8042 subjects (2-15 years) was obtained. A total of 47.35% reported having gone to dental services during the last year and 69.09% having gone sometime during their lives. Only 22.68% of the sample reported daily tooth brushing three times or more and 89.03% reported eating a cariogenic risk diet. In the school group (6-15 years) 29.87% of children whose mothers were university level brushed their teeth three times or more compared to 25.83% and 20.89% of those whose mothers had secondary and even primary studies respectively. For the intake of cariogenic risk diet, the percentages were 87.05%, 91.11% and 90.44%. In both age groups, and except for the consumption of sweets, there was a statistically significant association between maternal educational level and healthy habits. The prevalence of these healthy habits is far lower than the recommendations: a lower use of services and a lower frequency of daily tooth brushing and higher intake of a cariogenic risk diet. The outcomes are more favourable in both age groups when the mother are university level, wich may serve as a guide to the promotion of oral health. Copyright © 2011 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

  8. Vitamin-D status in a Population of Healthy Adults in Pakistan

    International Nuclear Information System (INIS)

    Mahmood, K.; Akhtar, S.T.; Talib, A.; Haider, I.

    2009-01-01

    Objective: To determine the prevalence of hypovitaminosis D and its predictors in healthy adult Pakistanis. This study was conducted at various hospitals in Karachi from April 2007 to September 2007. Methodology: In this study 244 healthy adults 16-62 years of age, visited hospital as an attendant of the patients and fulfilled the inclusion and exclusion criteria has been enrolled. After taking written consent a questionnaire regarding age, gender, occupation, duration of sun exposure, area of skin exposed, type of residence used, clothing and dietary habits were recorded. Serum 25-OH Vitamin D3 levels were determined by electro chemiluminescence method and Vitamin D deficiency was defined as a level <20 mu g/ml. serum calcium. Phosphorus and Alkaline Phosphatase were also measured in all of these subjects. Results: Among 244 subjects ranging from 16-62 years, 193(79%) were female. Subjects were predominantly married (72%), mostly residing in apartments (47.5%) and most of them (41.8%)only exposed their face and hands while outdoor. Duration of sun exposure in majority was 1-2 hour /day (42%). Majority used clothes of variable colour (72%) and fabric (41%). One hundred and eighty six (76.2%) subjects had deficiency of Vitamin D and significantly correlated with duration of sunlight exposure, large area of skin exposed, vitamin D in diet consumed and colour of clothes worn. Vitamin D was significantly correlated negatively with serum Phosphorus and Alkaline Phosphatase whereas serum calcium correlated positively. Conclusion: Prevalence of hypovitaminosis D among healthy Pakistanis is high and duration of sun exposure is the most common predictor of hypovitaminosis D. (author)

  9. Faecal microbiota of healthy adults in south India: Comparison of a tribal & a rural population.

    Science.gov (United States)

    Ramadass, Balamurugan; Rani, B Sandya; Pugazhendhi, Srinivasan; John, K R; Ramakrishna, Balakrishnan S

    2017-02-01

    The relevance of the gut microbiota to human health is increasingly appreciated. The objective of this study was to compare the gut microbiota of a group of adult tribals with that of healthy adult villagers in Tamil Nadu, India. Faeces were collected from 10 healthy tribal adults (TAs) in the Jawadhi hills and from 10 healthy villagers [rural adults (RAs)] in Vellore district, Tamil Nadu. DNA was extracted, and 456 bp segments comprising hypervariable regions 3 and 4 of the 16S rRNA gene were amplified, barcoded and 454 sequenced. Totally 227,710 good-quality reads were analyzed. TAs consumed a millets-based diet, ate pork every day, and did not consume milk or milk products. RAs consumed a rice-based diet with meat intake once a week. In both groups, Firmicutes was the most abundant phylum, followed by Proteobacteria, Bacteroidetes and Actinobacteria. The median Firmicutes-to-Bacteroidetes ratio was 34.0 in TA and 92.9 in RA groups. Actinobacteria were significantly low in TA, possibly due to non-consumption of milk. Clostridium constituted the most abundant genus in both groups, but was significantly more abundant in TAs than RAs, while Streptococcus was significantly more abundant in RA (P<0.05). Analyses of genetic distance revealed that the microbiota were distinctly different between TA and RA, and principal component analysis using 550 distinct taxonomically identifiable sequences revealed a clear separation of microbiota composition in the two groups. Phylogenetic analysis of major microbiota indicated clustering of microbial groups at different major branch points for TAs and RAs. Phylum Firmicutes and genus Clostridium constituted the bulk of the faecal microbiota, while significant differences in composition between the groups were probably due to differences in diet and lifestyle.

  10. Russian: An Active Introduction.

    Science.gov (United States)

    De La Cruz, Nina

    The Active Introduction is one of the modules in an array of materials used in Russian training for beginners at the Foreign Service Institute. It is essentially a catalog of sentences relating to typical daily activities which can be combined to form different communication sequences in dialog form. Students learn to speak Russian through…

  11. Heutiges Russisch (Contemporary Russian)

    Science.gov (United States)

    Russisch, 1976

    1976-01-01

    For the purpose of supplying information on actual contemporary Russian usage, this article excerpts sections on noun usage and variations of the genitive ending in the masculine singular from "Stilistik der russischen Sprache" (Russian Language Style) by D. Rosental and M. Telenkowa. (Text is in German.) (FB)

  12. Russian Language Course

    CERN Multimedia

    2009-01-01

    The Russian Cultural Circle is organising a new course of "Russian for Beginners", and is continuing a course for Advanced Students (3rd year). Interested persons are invited to contact: Mrs M. Mikhailova e-mail : mailto:mmmacha@hotmail.com Tel. 022 788 27 53

  13. Russian Language Analysis Project

    Science.gov (United States)

    Serianni, Barbara; Rethwisch, Carolyn

    2011-01-01

    This paper is the result of a language analysis research project focused on the Russian Language. The study included a diverse literature review that included published materials as well as online sources in addition to an interview with a native Russian speaker residing in the United States. Areas of study include the origin and history of the…

  14. Population pharmacokinetics of buprenorphine following a two-stage intravenous infusion in healthy volunteers

    DEFF Research Database (Denmark)

    Jensen, Mette Lykke; Foster, David J.R.; Upton, Richard N.

    2007-01-01

    The aim of this investigation was to characterize the pharmacokinetics of buprenorphine following administration of an intravenous (i.v.) infusion. To date, the population kinetics of buprenorphine has been described for bolus administration only.......The aim of this investigation was to characterize the pharmacokinetics of buprenorphine following administration of an intravenous (i.v.) infusion. To date, the population kinetics of buprenorphine has been described for bolus administration only....

  15. Food and water security issues in Russia I: food security in the general population of the Russian Arctic, Siberia and the Far East, 2000–2011

    Directory of Open Access Journals (Sweden)

    Alexey A. Dudarev

    2013-10-01

    Full Text Available Background. Problems related to food security in Russian Arctic (dietary imbalance, predominance of carbohydrates, shortage of milk products, vegetables and fruits, deficit of vitamins and microelements, chemical, infectious and parasitic food contamination have been defined in the literature. But no standard protocol of food security assessment has been used in the majority of studies. Objectives. Our aim was to obtain food security indicators, identified within an Arctic collaboration, for selected regions of the Russian Arctic, Siberia and the Far East, and to compare food safety in these territories. Study design and methods. In 18 regions of the Russian Arctic, Siberia and the Far East, the following indicators of food security were analyzed: food costs, food consumption, and chemical and biological food contamination for the period 2000–2011. Results. Food costs in the regions are high, comprising 23–43% of household income. Only 4 out of 10 food groups (fish products, cereals, sugar, plant oil are consumed in sufficient amounts. The consumption of milk products, eggs, vegetables, potatoes, fruits (and berries is severely low in a majority of the selected regions. There are high levels of biological contamination of food in many regions. The biological and chemical contamination situation is alarming, especially in Chukotka. Only 7 food pollutants are under regular control; among pesticides, only DDT. Evenki AO and Magadan Oblast have reached peak values in food contaminants compared with other regions. Mercury in local fish has not been analyzed in the majority of the regions. In 3 regions, no monitoring of DDT occurs. Aflatoxins have not been analyzed in 5 regions. Nitrates had the highest percentage in excess of the hygienic threshold in all regions. Excesses of other pollutants in different regions were episodic and as a rule not high. Conclusion. Improvement of the food supply and food accessibility in the regions of the Russian

  16. Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects

    Directory of Open Access Journals (Sweden)

    Kirsch Lee E

    2009-12-01

    Full Text Available Abstract Background The population pharmacokinetics of artesunate (AS and its active metabolite dihydroartemisinin (DHA were studied in healthy subjects receiving single- or multiple-dosing of AS orally either in combination with pyronaridine (PYR or as a monotherapy with or without food. Methods Data from 118 concentration-time profiles arising from 91 healthy Korean subjects were pooled from four Phase I clinical studies. Subjects received 2-5 mg/kg of single- and multiple-dosing of oral AS either in combination with PYR or as a monotherapy with or without food. Plasma AS and DHA were measured simultaneously using a validated liquid chromatography- mass spectrometric method with a lower limit of quantification of 1 ng/mL for both AS and DHA. Nonlinear mixed-effect modelling was used to obtain the pharmacokinetic and variability (inter-individual and residual variability parameter estimates. Results A novel parent-metabolite pharmacokinetic model consisting of a dosing compartment, a central compartment for AS, a central compartment and a peripheral compartment for DHA was developed. AS and DHA data were modelled simultaneously assuming stoichiometric conversion to DHA. AS was rapidly absorbed with a population estimate of absorption rate constant (Ka of 3.85 h-1. The population estimates of apparent clearance (CL/F and volume of distribution (V2/F for AS were 1190 L/h with 36.2% inter-individual variability (IIV and 1210 L with 57.4% IIV, respectively. For DHA, the population estimates of apparent clearance (CLM/F and central volume of distribution (V3/F were 93.7 L/h with 28% IIV and 97.1 L with 30% IIV, respectively. The population estimates of apparent inter-compartmental clearance (Q/F and peripheral volume of distribution (V4/F for DHA were 5.74 L/h and 18.5 L, respectively. Intake of high-fat and high-caloric meal prior to the drug administration resulted in 84% reduction in Ka. Body weight impacted CLM/F, such that a unit change in

  17. Population Pharmacokinetic Modelling of FE 999049, a Recombinant Human Follicle-Stimulating Hormone, in Healthy Women After Single Ascending Doses

    DEFF Research Database (Denmark)

    Rose, Trine Høyer; Röshammar, Daniel; Erichsen, Lars

    2016-01-01

    reproductive technologies. Methods: Serum FSH levels were measured following a single subcutaneous FE 999049 injection of 37.5, 75, 150, 225 or 450 IU in 27 pituitary-suppressed healthy female subjects participating in this first-in-human single ascending dose trial. Data was analysed by nonlinear mixed...... volume of distribution (V/F) estimates were found to increase with body weight. Body weight was included as an allometrically scaled covariate with a power exponent of 0.75 for CL/F and 1 for V/F. Conclusions: The single-dose pharmacokinetics of FE 999049 were adequately described by a population...

  18. The Russian oil

    International Nuclear Information System (INIS)

    Rucker, Laurent

    2003-01-01

    This article proposes a brief discussion of various assessments of Russian oil reserves, of the evolutions of Russian oil production (Russia is the second world producer after Saudi Arabia), of the distribution of Russian oil exports among various regions, and of the decrease of Russian oil consumption between 1992 and 2002. It describes the evolution of the actor system as the oil sector has been largely privatised since 1992, and indicates the main companies which should control the Russia market on a medium term. It also discusses the obstacles for the development of Production Sharing Agreements (PSA) between these companies. It addresses the issue of modernisation of the oil transport system as its status and its condition are often an obstacle to oil export for Russian companies. The article finally discusses the price issue, the relationship between Russia and other OPEC countries, and the need for huge investments

  19. The role of income and occupation in the association of education with healthy aging: results from a population-based, prospective cohort study.

    Science.gov (United States)

    White, Christine M; St John, Philip D; Cheverie, Madelon R; Iraniparast, Maryam; Tyas, Suzanne L

    2015-11-25

    The beneficial effects of higher education on healthy aging are generally accepted, but the mechanisms are less well understood. Education may influence healthy aging through improved employment opportunities that enhance feelings of personal control and reduce hazardous exposures, or through higher incomes that enable individuals to access better health care or to reside in better neighbourhoods. Income and occupation have not been explored extensively as potential mediators of the effect of education on healthy aging. This study investigates the role of income and occupation in the association between education and healthy aging including potential effect modification by gender. Logistic regression was used to explore the association of education, income (perceived income adequacy, life satisfaction with finances) and occupation (occupational prestige) with healthy aging five years later in 946 community-dwelling adults 65+ years from a population-based, prospective cohort study in Manitoba, Canada. Higher levels of education generally increased the likelihood of healthy aging. After adjusting for education, both income measures, but not occupation, predicted healthy aging among men; furthermore, the association between education and healthy aging was no longer significant. Income and occupation did not explain the significant association between education and healthy aging among women. Perceived income adequacy and life satisfaction with finances explained the beneficial effects of higher education on healthy aging among men, but not women. Identifying predictors of healthy aging and the mechanisms through which these factors exert their effects can inform strategies to maximize the likelihood of healthy aging.

  20. Short Sleep Duration Increases Metabolic Impact in Healthy Adults: A Population-Based Cohort Study.

    Science.gov (United States)

    Deng, Han-Bing; Tam, Tony; Zee, Benny Chung-Ying; Chung, Roger Yat-Nork; Su, Xuefen; Jin, Lei; Chan, Ta-Chien; Chang, Ly-Yun; Yeoh, Eng-Kiong; Lao, Xiang Qian

    2017-10-01

    The metabolic impact of inadequate sleep has not been determined in healthy individuals outside laboratories. This study aims to investigate the impact of sleep duration on five metabolic syndrome components in a healthy adult cohort. A total of 162121 adults aged 20-80 years (men 47.4%) of the MJ Health Database, who were not obese and free from major diseases, were recruited and followed up from 1996 to 2014. Sleep duration and insomnia symptoms were assessed by a self-administered questionnaire. Incident cases of five metabolic syndrome components were identified by follow-up medical examinations. Cox proportional hazard ratios (HRs) were calculated for three sleep duration categories " 8 hours/day (long)" with adjustment for potential confounding factors. Analyses were stratified by insomnia symptoms to assess whether insomnia symptoms modified the association between sleep duration and metabolic syndrome. Compared to regular sleep duration, short sleep significantly (p sleep decreased the risk of hypertriglyceridemia (adjusted HR 0.89 [0.84-0.94]) and metabolic syndrome (adjusted HR 0.93 [0.88-0.99]). Insomnia symptoms did not modify the effects of sleep duration. Sleep duration may be a significant determinant of metabolic health. © Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

  1. Does a low-income urban population practise healthy dietary habits?

    Science.gov (United States)

    Azizan, Nurul Ain; Thangiah, Nithiah; Su, Tin Tin; Majid, Hazreen Abdul

    2018-03-01

    The purpose of this study was to identify the unhealthy dietary habits and practices in a low-income community in an urban area and determine the associated factors. A cross-sectional survey was conducted in a low-income housing area in Kuala Lumpur, Malaysia. Data were collected using a questionnaire via face-to-face interviews by trained enumerators in order to obtain details on sociodemographic characteristics and dietary practices. Descriptive statistics showed that 86.7% of the respondents in the low-income community consumed fruit and vegetables less than five times per day, 11.7% consumed carbonated and sweetened drinks more than twice per day and about 25% consumed fast food more than four times per month. In total, 65.2% (n=945) did not have healthy dietary practices. Binary logistic regression showed that age, education and ethnicity were significant predictors of unhealthy dietary practices among the low-income community. Those in the 30-59 years age group had higher odds (odds ratio 1.65, p=0.04) of practising an unhealthy diet as compared with those older than 60 years of age. Unhealthy dietary practices were found to be common among the low-income group living in an urban area. Healthy lifestyle intervention should be highlighted so that it can be adopted in the low-income group.

  2. The less healthy urban population: income-related health inequality in China.

    Science.gov (United States)

    Yang, Wei; Kanavos, Panos

    2012-09-18

    Health inequality has been recognized as a problem all over the world. In China, the poor usually have less access to healthcare than the better-off, despite having higher levels of need. Since the proportion of the Chinese population living in urban areas increased tremendously with the urbanization movements, attention has been paid to the association between urban/rural residence and population health. It is important to understand the variation in health across income groups, and in particular to take into account the effects of urban/rural residence on the degree of income-related health inequalities. This paper empirically assesses the magnitude of rural/urban disparities in income-related adult health status, i.e., self-assessed health (SAH) and physical activity limitation, using Concentration Indices. It then uses decomposition methods to unravel the causes of inequalities and their variations across urban and rural populations. Data from the China Health and Nutrition Survey (CHNS) 2006 are used. The study finds that the poor are less likely to report their health status as "excellent or good" and are more likely to have physical activity limitation. Such inequality is more pronounced for the urban population than for the rural population. Results from the decomposition analysis suggest that, for the urban population, 76.47 per cent to 79.07 per cent of inequalities are driven by non-demographic/socioeconomic-related factors, among which income, job status and educational level are the most important factors. For the rural population, 48.19 per cent to 77.78 per cent of inequalities are driven by non-demographic factors. Income and educational attainment appear to have a prominent influence on inequality. The findings suggest that policy targeting the poor, especially the urban poor, is needed in order to reduce health inequality.

  3. The less healthy urban population: income-related health inequality in China

    Science.gov (United States)

    2012-01-01

    Background Health inequality has been recognized as a problem all over the world. In China, the poor usually have less access to healthcare than the better-off, despite having higher levels of need. Since the proportion of the Chinese population living in urban areas increased tremendously with the urbanization movements, attention has been paid to the association between urban/rural residence and population health. It is important to understand the variation in health across income groups, and in particular to take into account the effects of urban/rural residence on the degree of income-related health inequalities. Methods This paper empirically assesses the magnitude of rural/urban disparities in income-related adult health status, i.e., self-assessed health (SAH) and physical activity limitation, using Concentration Indices. It then uses decomposition methods to unravel the causes of inequalities and their variations across urban and rural populations. Data from the China Health and Nutrition Survey (CHNS) 2006 are used. Results The study finds that the poor are less likely to report their health status as “excellent or good” and are more likely to have physical activity limitation. Such inequality is more pronounced for the urban population than for the rural population. Results from the decomposition analysis suggest that, for the urban population, 76.47 per cent to 79.07 per cent of inequalities are driven by non-demographic/socioeconomic-related factors, among which income, job status and educational level are the most important factors. For the rural population, 48.19 per cent to 77.78 per cent of inequalities are driven by non-demographic factors. Income and educational attainment appear to have a prominent influence on inequality. Conclusion The findings suggest that policy targeting the poor, especially the urban poor, is needed in order to reduce health inequality. PMID:22989200

  4. The less healthy urban population: income-related health inequality in China

    Directory of Open Access Journals (Sweden)

    Yang Wei

    2012-09-01

    Full Text Available Abstract Background Health inequality has been recognized as a problem all over the world. In China, the poor usually have less access to healthcare than the better-off, despite having higher levels of need. Since the proportion of the Chinese population living in urban areas increased tremendously with the urbanization movements, attention has been paid to the association between urban/rural residence and population health. It is important to understand the variation in health across income groups, and in particular to take into account the effects of urban/rural residence on the degree of income-related health inequalities. Methods This paper empirically assesses the magnitude of rural/urban disparities in income-related adult health status, i.e., self-assessed health (SAH and physical activity limitation, using Concentration Indices. It then uses decomposition methods to unravel the causes of inequalities and their variations across urban and rural populations. Data from the China Health and Nutrition Survey (CHNS 2006 are used. Results The study finds that the poor are less likely to report their health status as “excellent or good” and are more likely to have physical activity limitation. Such inequality is more pronounced for the urban population than for the rural population. Results from the decomposition analysis suggest that, for the urban population, 76.47 per cent to 79.07 per cent of inequalities are driven by non-demographic/socioeconomic-related factors, among which income, job status and educational level are the most important factors. For the rural population, 48.19 per cent to 77.78 per cent of inequalities are driven by non-demographic factors. Income and educational attainment appear to have a prominent influence on inequality. Conclusion The findings suggest that policy targeting the poor, especially the urban poor, is needed in order to reduce health inequality.

  5. Differences in healthy life expectancy for the US population by sex, race/ethnicity and geographic region: 2008.

    Science.gov (United States)

    Chang, Man-Huei; Molla, Michael T; Truman, Benedict I; Athar, Heba; Moonesinghe, Ramal; Yoon, Paula W

    2015-09-01

    Healthy life expectancy (HLE) varies among demographic segments of the US population and by geography. To quantify that variation, we estimated the national and regional HLE for the US population by sex, race/ethnicity and geographic region in 2008. National HLEs were calculated using the published 2008 life table and the self-reported health status data from the National Health Interview Survey (NHIS). Regional HLEs were calculated using the combined 2007-09 mortality, population and NHIS health status data. In 2008, HLE in the USA varied significantly by sex, race/ethnicity and geographical regions. At 25 years of age, HLE for females was 47.3 years and ∼2.9 years greater than that for males at 44.4 years. HLE for non-Hispanic white adults was 2.6 years greater than that for Hispanic adults and 7.8 years greater than that for non-Hispanic black adults. By region, the Northeast had the longest HLE and the South had the shortest. The HLE estimates in this report can be used to monitor trends in the health of populations, compare estimates across populations and identify health inequalities that require attention. Published by Oxford University Press on behalf of Faculty of Public Health 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

  6. Approaches in methodology for population-based longitudinal study on neuroprotective model for healthy longevity (TUA) among Malaysian Older Adults.

    Science.gov (United States)

    Shahar, Suzana; Omar, Azahadi; Vanoh, Divya; Hamid, Tengku Aizan; Mukari, Siti Zamratol Mai-Sarah; Din, Normah Che; Rajab, Nor Fadilah; Mohammed, Zainora; Ibrahim, Rahimah; Loo, Won Hui; Meramat, Asheila; Kamaruddin, Mohd Zul Amin; Bagat, Mohamad Fazdillah; Razali, Rosdinom

    2016-12-01

    A number of longitudinal studies on aging have been designed to determine the predictors of healthy longevity, including the neuroprotective factors, however, relatively few studies included a wide range of factors and highlighted the challenges faced during data collection. Thus, the longitudinal study on neuroprotective model for healthy longevity (LRGS TUA) has been designed to prospectively investigate the magnitude of cognitive decline and its risk factors through a comprehensive multidimensional assessment comprising of biophysical health, auditory and visual function, nutrition and dietary pattern and psychosocial aspects. At baseline, subjects were interviewed for their status on sociodemographic, health, neuropsychological test, psychosocial and dietary intake. Subjects were also measured for anthropometric and physical function and fitness. Biospecimens including blood, buccal swap, hair and toenail were collected, processed and stored. A subsample was assessed for sensory function, i.e., vision and auditory. During follow-up, at 18 and 36 months, most of the measurements, along with morbidity and mortality outcomes will be collected. The description of mild cognitive impairment, successful aging and usual aging process is presented here. A total 2322 respondents were recruited in the data analysis at baseline. Most of the respondents were categorized as experiencing usual aging (73 %), followed by successful aging (11 %) and mild cognitive impairment (16 %). The LRGS TUA study is the most comprehensive longitudinal study on aging in Malaysia, and will contribute to the understanding of the aging process and factors associated with healthy aging and mental well-being of a multiethnic population in Malaysia.

  7. Prevalence of restless legs syndrome and associated factors in an otherwise healthy population

    DEFF Research Database (Denmark)

    Didriksen, Maria; Rigas, Andreas S; Allen, Richard P

    2017-01-01

    are therefore an ideal population for studying factors associated with RLS occurrence, herein the role of iron. It is suggested that RLS is linked to sex, age, low socioeconomic status, unhealthy lifestyle, and iron deficiency. The objective of this study is therefore to estimate the RLS prevalence and identify...... associated biological, sociodemographic, economic, and lifestyle factors in a population of blood donors. Methods A total of 13,448 blood donors enrolled in the Danish Blood Donor Study from May 2015 to May 2016. RLS cases were identified using the validated Cambridge–Hopkins RLS-questionnaire. Logistic...

  8. Clinical chemistry reference intervals of healthy adult populations in Gojjam Zones of Amhara National Regional State, Northwest Ethiopia.

    Science.gov (United States)

    Mekonnen, Zewdie; Amuamuta, Asmare; Mulu, Wondemagegn; Yimer, Mulat; Zenebe, Yohannes; Adem, Yesuf; Abera, Bayeh; Gebeyehu, Wondemu; Gebregziabher, Yakob

    2017-01-01

    Reference interval is crucial for disease screening, diagnosis, monitoring, progression and treatment efficacy. Due to lack of locally derived reference values for the parameters, clinicians use reference intervals derived from western population. But, studies conducted in different African countries have indicated differences between locally and western derived reference values. Different studies also indicated considerable variation in clinical chemistry reference intervals by several variables such as age, sex, geographical location, environment, lifestyle and genetic variation. This study aimed to determine the reference intervals of common clinical chemistry parameters of the community of Gojjam Zones, Northwest Ethiopia. Population based cross-sectional study was conducted from November 2015 to December 2016 in healthy adult populations of Gojjam zone. Data such as, medical history, physical examination and socio-demographic data were collected. In addition, laboratory investigations were undertaken to screen the population. Clinical chemistry parameters were measured using Mindray BS 200 clinical chemistry autoanalyzer as per the manufacturer's instructions. Descriptive statistics was used to calculate mean, median and 95th percentiles. Independent sample T-test and one way ANOVA were used to see association between variables. After careful screening of a total of 799 apparently healthy adults who were consented for this study, complete data from 446 (224 females and 222 males) were included for the analysis. The mean age of both the study participants was 28.8 years. Males had high (Preference intervals of amylase, LDH, total protein and total bilirubin were not significantly different between the two sex groups (P>0.05). Mean, median, 95% percentile values of AST, ALP, amylase, LDH, creatinine, total protein, total bilirubin, and direct bilirubin across all age groups of participants were similar (P>0.05). But, there was a significant difference in the

  9. Effects of Lifestyle on Muscle Strength in a Healthy Danish Population

    DEFF Research Database (Denmark)

    Bartels, Else Marie; Robertson, Samuel; Danneskiold-Samsøe, Bente

    2018-01-01

    The Copenhagen City Heart Study (CCHS) and measurements of Isokinetic muscle strength from a sub-study of randomly selected healthy participants from CCHS. Methods: 126 women and 63 men were studied. All participants completed a questionnaire regarding their lifestyle, including physical activity, alcohol intake...... in the lower extremities (p = 0.03) for women, and lower extremities (p = 0.03) and trunk (p = 0.007) for men. Alcohol Intake was in general not correlated to muscle strength. No clear effect of smoking was seen on muscle strength. Conclusion: Our results show that physical activity during leisure...... and smoking habits. Isokinetic muscle strength was measured over the upper extremities (UE), trunk, and lower extremities (LE). Multivariate analyses including all of the variables were carried out. Results: The level of daily physical activity during leisure was positively correlated to muscle strength...

  10. Effects of Lifestyle on Muscle Strength in a Healthy Danish Population

    DEFF Research Database (Denmark)

    Bartels, Else Marie; Robertson, Samuel; Danneskiold-Samsøe, Bente

    2018-01-01

    The Copenhagen City Heart Study (CCHS) and measurements of Isokinetic muscle strength from a sub-study of randomly selected healthy participants from CCHS. Methods: 126 women and 63 men were studied. All participants completed a questionnaire regarding their lifestyle, including physical activity, alcohol intake...... in the lower extremities (p = 0.03) for women, and lower extremities (p = 0.03) and trunk (p = 0.007) for men. Alcohol Intake was in general not correlated to muscle strength. No clear effect of smoking was seen on muscle strength. Conclusions: Our results show that physical activity during leisure...... and smoking habits. Isokinetic muscle strength was measured over the upper extremities (UE), trunk, and lower extremities (LE). Multivariate analyses including all of the variables were carried out. Results: The level of daily physical activity during leisure was positively correlated to muscle strength...

  11. Development of a Healthy Aging Score in the Population-Based Rotterdam Study: Evaluating Age and Sex Differences.

    Science.gov (United States)

    Jaspers, Loes; Schoufour, Josje D; Erler, Nicole S; Darweesh, Sirwan K L; Portegies, Marileen L P; Sedaghat, Sanaz; Lahousse, Lies; Brusselle, Guy G; Stricker, Bruno H; Tiemeier, Henning; Ikram, M Arfan; Laven, Joop S E; Franco, Oscar H; Kavousi, Maryam

    2017-03-01

    To develop a healthy aging score (HAS), to assess age and sex differences in HAS, and to evaluate the association of the HAS with survival. Prospective population-based cohort. Inhabitants of Ommoord, Rotterdam, The Netherlands. A total of 1405 men and 2122 women, mean (standard deviation) age 75.9 (6.4) years. We included 7 domains in the total score of HAS: chronic diseases, mental health, cognitive function, physical function, pain, social support, and quality of life; each scored 0, 1, or 2 in each domain. A total score (range 0-14) was constructed and was assessed continuously and in tertiles (13-14: healthy aging, 11-12: intermediate aging, 0-10: poor aging). Sex-specific change in the mean HAS was computed for the age categories of 65-69, 70-74, 75-79, 80-84, and ≥85 years. The association between HAS and mortality was assessed with Cox proportional hazards models. Mean follow-up was 8.6 (3.4) years. Men had poorer scores in the chronic disease domain than women. However, women had poorer mental health, worse physical function, more pain, and lower quality of life compared with men. The prevalence of healthy aging was higher in men (n = 396, 28.2%), than in women (n = 526, 24.8%). The mean (standard deviation) HAS was 11.1 (2.2) in men and 10.7 (2.3) in women. Mean HAS was higher in men than in women for all age categories. The β for change in mean HAS across the 5 increasing age categories was -0.55 (-0.65 to -0.45) in men and -0.65 (-0.73 to -0.57) in women. The age-adjusted hazard ratio per unit increase in HAS with mortality was 0.86 (0.83-0.89) in men, and 0.89 (0.87-0.91) in women. Levels of HAS were lower in women compared with men, in all age categories. The HAS declined with increasing age for both sexes, albeit slightly steeper in women. The HAS was strongly associated with mortality in both sexes. A better understanding of population healthy aging and sex differences in this regard could aid to implement strategies for sustainable

  12. Population-based evaluation of the 'LiveLighter' healthy weight and lifestyle mass media campaign.

    Science.gov (United States)

    Morley, B; Niven, P; Dixon, H; Swanson, M; Szybiak, M; Shilton, T; Pratt, I S; Slevin, T; Hill, D; Wakefield, M

    2016-04-01

    The Western Australian (WA) 'LiveLighter' (LL) mass media campaign ran during June-August and September-October 2012. The principal campaign ad graphically depicts visceral fat of an overweight individual ('why' change message), whereas supporting ads demonstrate simple changes to increase activity and eat healthier ('how' to change message). Cross-sectional surveys among population samples aged 25-49 were undertaken pre-campaign (N= 2012) and following the two media waves (N= 2005 and N= 2009) in the intervention (WA) and comparison state (Victoria) to estimate the population impact of LL. Campaign awareness was 54% after the first media wave and overweight adults were more likely to recall LL and perceive it as personally relevant. Recall was also higher among parents, but equal between socio-economic groups. The 'why' message about health-harms of overweight rated higher than 'how' messages about lifestyle change, on perceived message effectiveness which is predictive of health-related intention and behaviour change. State-by-time interactions showed population-level increases in self-referent thoughts about the health-harms of overweight (P stereotypes of overweight individuals did not increase after LL aired. LL was associated with some population-level improvements in proximal and intermediate markers of campaign impact. However, sustained campaign activity will be needed to impact behaviour. © The Author 2016. Published by Oxford University Press.

  13. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population.

    Science.gov (United States)

    Cox, Katherine H M; Pipingas, Andrew; Scholey, Andrew B

    2015-05-01

    Curcumin possesses many properties which may prevent or ameliorate pathological processes underlying age-related cognitive decline, dementia or mood disorders. These benefits in preclinical studies have not been established in humans. This randomized, double-blind, placebo-controlled trial examined the acute (1 and 3 h after a single dose), chronic (4 weeks) and acute-on-chronic (1 and 3 h after single dose following chronic treatment) effects of solid lipid curcumin formulation (400 mg as Longvida®) on cognitive function, mood and blood biomarkers in 60 healthy adults aged 60-85. One hour after administration curcumin significantly improved performance on sustained attention and working memory tasks, compared with placebo. Working memory and mood (general fatigue and change in state calmness, contentedness and fatigue induced by psychological stress) were significantly better following chronic treatment. A significant acute-on-chronic treatment effect on alertness and contentedness was also observed. Curcumin was associated with significantly reduced total and LDL cholesterol and had no effect on hematological safety measures. To our knowledge this is the first study to examine the effects of curcumin on cognition and mood in a healthy older population or to examine any acute behavioral effects in humans. Results highlight the need for further investigation of the potential psychological and cognitive benefits of curcumin in an older population. © The Author(s) 2014.

  14. CHLAMYDIA PNEUMONIAE – THE PREVALENCE OF ANTIBODIES IN HEALTHY POPULATION AND IN PATIENTS WITH COMMUNITY ACQUIRED PNEUMONIA

    Directory of Open Access Journals (Sweden)

    Darja Keše

    2001-06-01

    Full Text Available Background. To determinate the prevalence rates of Chlamydia pneumoniae infections in Slovenia and to evaluate the importance of C. pneumoniae infections at patients with community acquired pneumonia (CAP.Materials and methods. With the microimmunofluorescence test (micro-IF we evaluated the presence of C. pneumoniae specific antibodies in 1036 healthy subjects, in two periods of time, in 1991–93 and 1997–1998. We also tested the pair sera collected from 2118 patients with CAP between 1993–1999.Results. We demonstrated that C. pneumoniae infections are common in our population, as we detected IgG antibodies in 43.1% of healthy population. The prevalence rate of C. pneumoniae infections statistically significant increased in two periods of time. Acute C. pneumoniae infections were proved in 15.9% of all patients with CAP.Conclusions. C. pneumoniae is important respiratory pathogen also in our community. The infections are more common in older patients. Because C. pneumoniae like other Chlamydia species has tendency to cause chronic disease, it is reasonable to diagnose this bacterium in respiratory patients. It is also recommended to test convalescent sera at serologic laboratory diagnosis.

  15. Serum 25-Hydroxyvitamin D Concentration Is Independently Inversely Associated with Insulin Resistance in the Healthy, Non-Obese Korean Population

    Directory of Open Access Journals (Sweden)

    So Young Ock

    2016-07-01

    Full Text Available BackgroundWe evaluated the associations between 25-hydroxyvitamin D (25(OHD concentrations in serum and insulin resistance in the healthy Korean population.MethodsWe conducted this cross-sectional analysis in 1,807 healthy Korean people (628 men and 1,179 women aged 30 to 64 years in the Cardiovascular and Metabolic Disease Etiologic Research Center study. All participants were assessed for 25(OHD, fasting glucose, and insulin levels, and completed a health examination and lifestyle questionnaire according to standard procedures. Insulin resistance was defined as the homeostasis model assessment insulin resistance higher than the 75 percentile.ResultsCompared to those in the highest tertile (≥14.3 ng/mL, the odds ratio (OR for insulin resistance was 1.37 (95% confidence interval [CI], 1.01 to 1.86 for the 1st tertile (<9.7 ng/mL and 1.19 (95% CI, 0.08 to 1.62 for the 2nd tertile (9.7 to 14.3 ng/mL after adjusting for age, gender, waist circumference, alcohol consumption, smoking status, physical exercise, season, and cohort. After stratification of the subjects by adiposity, these associations remained only in non-obese subjects (lowest tertile vs. highest tertile, multivariable OR, 1.64; 95% CI, 1.05 to 2.56.ConclusionSerum 25(OHD has an independent inverse association with insulin resistance in the healthy, non-obese Korean population, even among people with vitamin D insufficiency.

  16. Population pharmacokinetics of olmesartan following oral administration of its prodrug, olmesartan medoxomil: in healthy volunteers and hypertensive patients.

    Science.gov (United States)

    Yoshihara, Kazutaka; Gao, Yuying; Shiga, Hiroshi; Wada, D Russell; Hisaoka, Masafumi

    2005-01-01

    Olmesartan medoxomil (CS-866) is a new orally active angiotensin II receptor antagonist that is highly selective for the AT1 receptor subtype. To develop a population pharmacokinetic model for olmesartan (RNH-6270), the active metabolite of olmesartan medoxomil, in healthy volunteers and hypertensive patients, and to evaluate effects of covariates on the apparent oral clearance (CL/F), with particular emphasis on the effect of race. Retrospective analysis of data from 12 phase I-III trials in the US, Europe and Japan. Eighty-nine healthy volunteers and 383 hypertensive patients. Nonlinear mixed-effects modelling was used to evaluate 7911 olmesartan plasma sample concentrations. The covariates included age, bodyweight, sex, race (Westerners [including Caucasians and Hispanics] versus Japanese), patient status (hypertensive patients versus healthy volunteers), serum creatinine level as an index of renal function and serum chemistry data as indices of hepatic function. The pharmacokinetic data of olmesartan were well described by a two-compartment linear model with first-order absorption and an absorption lag-time, parameterised in terms of CL/F (6.66 L/h for a typical male Western hypertensive patient), absorption rate constant (1.46h-1), elimination rate constant (0.193h-1), rate constant from the central to peripheral compartment (0.061h-1), rate constant from the peripheral to central compartment (0.079h-1) and absorption lag-time (0.427h). Analysis of covariates showed that age, bodyweight, sex, patient status and renal function were factors influencing the clearance of olmesartan. The population pharmacokinetic analysis of olmesartan showed that: (i) severe renal impairment (serum creatinine >265 micromol/L [approximately 3 mg/dL]) could cause a clearance decrease of > or =30%; (ii) older age, lower bodyweight and being female were determinants of lower clearance but their effects on olmesartan clearance were within 20%; (iii) no statistically significant

  17. Reference interval for the disc-macula distance to disc diameter ratio in a large population of healthy Japanese adults

    Science.gov (United States)

    Sato, Ken-ichi

    2017-01-01

    Abstract This study presents the calculated reference interval for the disc-to-macula distance to disc diameter ratio (DM:DD) based on a large population of healthy Japanese adults. A total of 308 consecutive, healthy Japanese adults were examined in this prospective observational study. Eighteen subjects were also excluded because of poor quality of the fundus photograph of one or both eyes; 290 (161 men and 129 women) were included in this study. For each subject, a color fundus photograph of one eye, either the right or left, was randomly selected and used for analysis. On the photograph, the distances between the fovea and the nearest temporal margin of the optic disc (Dft), and the two kinds of disc diameters (D1 and D2), which bisected at right angles and one of which was directed to the fovea (D1), were measured. DM:DD was estimated using the formula: (2Dft + D1)/(D1 + D2). The mean ± standard deviation of DM:DD was 2.91 ± 0.49 for men and 2.96 ± 0.54 for women; there was no sex difference (P = .78, Mann–Whitney U test). Also, almost no relationship was found between DM:DD and age (ρ = −.12, P = .04, Spearman's rank correlation coefficient). The data did not fit a normal distribution (P < .001, Kolmogorov–Smirnov test). The estimated reference interval for DM:DD corresponding to the 2.5th and 97.5th percentiles was 2.12 to 4.18. Using a nonparametric approach, the reference interval for DM:DD of a large population of healthy Japanese adults was calculated to be 2.12 to 4.18, regardless of age or sex. PMID:28403107

  18. Dietary Protein Intake in a Multi-ethnic Asian Population of Healthy Participants and Chronic Kidney Disease Patients.

    Science.gov (United States)

    Teo, Boon Wee; Toh, Qi Chun; Xu, Hui; Yang, Adonsia Y T; Lin, Tingxuan; Li, Jialiang; Lee, Evan J C

    2015-04-01

    Clinical practice guidelines recommend different levels of dietary protein intake in predialysis chronic kidney disease (CKD) patients. It is unknown how effectively these recommendations perform in a multi-ethnic Asian population, with varied cultural beliefs and diets. We assess the profi le of protein intake in a multi-ethnic Asian population, comparing healthy participants and CKD patients. We analysed the 24-hour urine collections of the Asian Kidney Disease Study (AKDS) and the Singapore Kidney Function Study (SKFS) to estimate total protein intake (TPI; g/day). We calculated ideal body weight (IDW; kg): 22.99 × height2 (m). Standard statistical tests were applied where appropriate, and linear regression was used to assess associations of continuous variables with protein intake. There were 232 CKD patients and 103 healthy participants with 35.5% diabetics. The mean TPI in healthy participants was 58.89 ± 18.42 and the mean TPI in CKD patients was 53.64 ± 19.39. By US National Kidney Foundation (NKF) guidelines, 29/232 (12.5%) of CKD patients with measured glomerular filtration rate (GFR) patients had TPI-IDW >0.75g/kg/ day. By American Dietetic Association (ADA) guidelines, 34.7% (44/127) of CKD patients with GFR patients with GFR protein intake of between 0.3 to 0.5 g/kg/day. A total of 21.9% (25/114) of diabetic CKD patients had protein intake between 0.8 to 0.9 g/kg/day. On average, the protein intake of most CKD patients exceeds the recommendations of guidelines. Diabetic CKD patients should aim to have higher protein intakes.

  19. Russian Language in the Central Asia Region

    Directory of Open Access Journals (Sweden)

    Ksenia Petrovna Borishpolets

    2014-01-01

    Full Text Available He article is devoted to the role of the Russian language in Central Asia and its development perspectives in the context of the Eurasian integration processes. Russian language has a long historical tradition in Central Asia and hasn't lost its importance even at the background of two waves of "derussification" that took place after 1991. Notwithstanding the decrease of the status, it keeps substantial public significance. During last two decades only in Turkmenistan we are witnessing the decrease in spreading of the Russian language among title population of the Central Asia region. Its positions as an active communication channel is secured not only by the social tradition, but also by the competitiveness of the Russian language education, advantages of the bilingual business, requirements of the labor migrants, HR interests and by some other pragmatic thoughts, which role within the context of Eurasian economic integration will increase. Despite the difficulties, it is too early to speak about the decrease of the Russian language in the Central Asia region. It is more likely that the institutes itself that maintain it and promoting it are at the low ebb. New scales and forms of practical work that is interested not only for Russia, but also Central Asia countries are required. Pressure on the resources of the Russian language increases the possibility of ethnic conflicts and strengthens the positions of political radicalism in Central Asia region.

  20. The Super-Seniors Study: Phenotypic characterization of a healthy 85+ population.

    Science.gov (United States)

    Halaschek-Wiener, Julius; Tindale, Lauren C; Collins, Jennifer A; Leach, Stephen; McManus, Bruce; Madden, Kenneth; Meneilly, Graydon; Le, Nhu D; Connors, Joseph M; Brooks-Wilson, Angela R

    2018-01-01

    To understand why some people live to advanced age in good health and others do not, it is important to study not only disease, but also long-term good health. The Super-Seniors Study aims to identify factors associated with healthy aging. 480 healthy oldest-old 'Super-Seniors' aged 85 to 105 years and never diagnosed with cancer, cardiovascular disease, diabetes, dementia, or major pulmonary disease, were compared to 545 mid-life controls aged 41-54, who represent a group that is unselected for survival from late-life diseases. Health and lifestyle information, personal and family medical history, and blood samples were collected from all participants. Super-Seniors also underwent four geriatric tests. Super-Seniors showed high cognitive (Mini-Mental State Exam mean = 28.3) and functional capacity (Instrumental Activities of Daily Living Scale mean = 21.4), as well as high physical function (Timed Up and Go mean = 12.3 seconds) and low levels of depression (Geriatric Depression Scale mean = 1.5). Super-Seniors were less likely to be current smokers than controls, but the frequency of drinking alcohol was the same in both groups. Super-Seniors were more likely to have 4 or more offspring; controls were more likely to have no children. Female Super-Seniors had a mean age of last fertility 1.9 years older than controls, and were 2.3 times more likely to have had a child at ≥ 40 years. The parents of Super-Seniors had mean ages of deaths of 79.3 years for mothers, and 74.5 years for fathers, each exceeding the life expectancy for their era by a decade. Super-Seniors are cognitively and physically high functioning individuals who have evaded major age-related chronic diseases into old age, representing the approximately top 1% for healthspan. The familiality of long lifespan of the parents of Super-Seniors supports the hypothesis that heritable factors contribute to this desirable phenotype.

  1. The Effect of a Diving Mask on Intraocular Pressure in a Healthy Population

    Directory of Open Access Journals (Sweden)

    Catherina Josephine Goenadi

    2016-06-01

    Full Text Available Purpose: Swimming goggles increase the intraocular pressure (IOP via the periorbital frame pressure and suction effect. In comparison, diving masks have a larger frame rim and incorporate the nose. The exact effect(s of diving masks on IOP is unknown. This study evaluates the influence of diving masks on IOP in normal, healthy subjects. Methods: Tonometry was performed in both eyes of all subjects with an AVIA®Tono-Pen by a single investigator. Measurements were taken at baseline without the diving mask and with the subjects wearing a small-volume, double-window diving mask, but with the mask lenses removed. Two IOP readings in each eye were measured, and an additional reading was measured if the difference between the initial 2 was ≥2 mm Hg. Central corneal thickness (CCT was also measured in each eye, using a contact pachymeter (OcuScan®Alcon. Results: Forty eyes of 20 healthy volunteers (age 29.7 ± 9.3 years; range 21–52 were included. The mean CCT was 544.4 ± 43.5 µm. The mean IOP before the diving mask was worn had been 17.23 ± 2.18 mm Hg (n = 40. The IOP decreased by 0.43 mm Hg (p < 0.05 to 16.80 ± 2.57 mm Hg after the diving mask had been put on. There was no correlation between IOP change and age (r = 0.143, p = 0.337, gender (r = –0.174, p = 0.283 or CCT (r = –0.123, p = 0.445. Conclusion: There was no increase in IOP after the diving mask had been worn. A small but statistically significant decrease in IOP was observed. This study demonstrates that unlike swimming goggles, the strap tension and frame pressure on the periorbital tissue from a diving mask does not increase IOP. Diving masks may be a suitable alternative to swimming goggles for patients with advanced glaucoma or glaucoma filtration surgery.

  2. Relationship Between Neck Circumference and Epicardial Fat Thickness in a Healthy Male Population

    Directory of Open Access Journals (Sweden)

    Uğur Küçük

    2016-01-01

    Full Text Available Abstract Background: Epicardial fat is an upper body visceral fat depot that may play a significant role in the development of adverse metabolic and cardiovascular risk profiles. There is a significant direct relationship between the amount of epicardial fat and general body adiposity (body mass index, BMI, but data regarding subcutaneous adiposity is limited. Objective: We conducted a study to determine the association between neck circumference and epicardial fat thickness in healthy young male individuals, and assess their individual correlations with general body adiposity and cardiometabolic risk factors. Methods: One hundred consecutive male patients aged 18 years or older with no known major medical conditions were included in the study. All participants underwent detailed physical examination including measurement of blood pressure, weight, height, waist/hip ratio, and neck circumference. Blood was collected to determine fasting glucose and lipid parameters. A standard echocardiographic examination was performed with additional epicardial fat thickness determination. Results: Among 100 study participants, neck circumference correlated significantly with weight, waist circumference, BMI, blood glucose, serum total cholesterol, low-density (LDL-cholesterol, and triglycerides levels. No significant correlation was found between neck circumference and high-density lipoprotein (HDL-cholesterol levels. Neck circumference correlated moderately and positively with echocardiographic epicardial fat thickness. Conclusion: Among patients with low cardiometabolic risk, increased neck circumference was associated with increased epicardial fat thickness.

  3. Cardiovascular responses to energy drinks in a healthy population: The C-energy study.

    Science.gov (United States)

    Kozik, Teri M; Shah, Sachin; Bhattacharyya, Mouchumi; Franklin, Teresa T; Connolly, Therese Farrell; Chien, Walter; Charos, George S; Pelter, Michele M

    2016-07-01

    Energy drink consumption has increased significantly over the past decade and is associated with greater than 20,000 emergency department visits per year. Most often these visits are due to cardiovascular complaints ranging from palpitations to cardiac arrest. To determine if energy drinks alter; blood pressure, electrolytes, activated bleeding time (ACT), and/or cardiac responses measured with a 12-lead electrocardiographic (ECG) Holter. Continuous ECG data was collected for five hours (30 minutes baseline and 4 hours post consumption [PC]). Subjects consumed 32 ounces of energy drink within one hour and data (vital signs and blood samples) was collected throughout the study period. Paired students t-test and a corresponding non-parametric test (Wilcoxon signed rank) were used for analysis of the data. Fourteen healthy young subjects were recruited (mean age 28.6 years). Systolic blood pressure (baseline=132, ±7.83; PC=151, ±11.21; P=.001); QTc interval (baseline=423, ±22.74; PC=503, ±24.56; P500 milliseconds PC. Other T-wave changes were noted in 9/14 (64.3%) subjects PC. Energy drinks increased systolic blood pressure, altered electrolytes, and resulted in repolarization abnormalities. These physiological responses can lead to arrhythmias and other abnormal cardiac responses highlighting the importance that emergency room personnel assess for energy drink consumption and potential toxicity. Copyright © 2016. Published by Elsevier Inc.

  4. Eat healthy? Attitudes of the German population towards industrially produced cardioprotective food.

    Science.gov (United States)

    Jung, F U C E; Luck-Sikorski, C; Krüger, M; Wiacek, C; Braun, P G; Engeli, S; Riedel-Heller, S G

    2018-05-01

    Cardiovascular disease (CVD) is likely to increase in incidence. Foods with cardioprotective functions, e.g. specific functional food, could reduce CVD risk factors and hence CVD incidence. Little is known about industrially modified foods with cardioprotective functions. In a large German sample (n = 1007), attitudes of consumers in Germany towards industrially produced cardioprotective food were assessed using Cluster analyses. Consumers were contacted via telephone and interviewed using questionnaires. Overall, about 25% knew about industrially produced food with cardioprotective function. Our analysis revealed a small but determined group of consumers who think very skeptical about cardioprotective products, but we also identified a favorable group. These two groups only differed in age, with the skeptical group being ten years older. The rising number of industrially modified products with potential cardioprotective benefit is met by skepticism and a lack of knowledge by German costumers. If large scale studies show health benefits of these products, these will need to be better communicated to German customers in order to address possible doubts or concerns and to encourage healthy eating habits in consumer eating behavior. Copyright © 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

  5. Effects of respiratory manoeuvres on hepatic vein Doppler waveform and flow velocities in a healthy population

    International Nuclear Information System (INIS)

    Altinkaya, Naime; Koc, Zafer; Ulusan, Serife; Demir, Senay; Gurel, Kamil

    2011-01-01

    Objective: This study was performed to determine the variations in Doppler waveforms and flow velocity during respiratory manoeuvres in healthy individuals with no liver disease. Materials and methods: In total, 100 individuals (75 women and 25 men) without known cardiac or liver disease were examined prospectively with duplex Doppler ultrasonography (US). We recorded the Doppler waveforms and peak systolic velocities (V max ) of the middle hepatic vein during normal respiration, during breath-holding after quiet expiration and also during deep inspiration. Doppler waveforms are categorised as triphasic, biphasic or monophasic. Results: During normal respiration, hepatic venous waveforms were triphasic in 93% of subjects, monophasic in 6% and biphasic in 1%. During breath-holding after quiet expiration, the percentages were 91%, 6% and 3%, respectively. During deep inspiration, they were 80%, 18% and 2%, respectively. Although significant differences were noted between rates during deep inspiration and normal respiration, they were quite similar during normal respiration and breath-holding after quiet expiration (P max were significantly higher during normal respiration compared to quiet expiration and during quiet expiration compared to deep inspiration (P < 0.05). Conclusion: The velocities and waveforms of hepatic veins varied during respiratory manoeuvres. The status of respiration must be taken into consideration whilst examining the hepatic vein waveforms and velocities with duplex Doppler US.

  6. Knowledge of hepatitis B among healthy population: A community-based survey from two districts of Gujarat, India.

    Science.gov (United States)

    Yasobant, Sandul; Trivedi, Poonam; Saxena, Deepak; Puwar, Tapasvi; Vora, Kranti; Patel, Mayur

    2017-01-01

    Hepatitis B is the world's most common blood-borne viral infection, accounting for 2 billion infections, 350 million carriers, and 6 lakh deaths annually. Country like India still harbors approximately 30-60 million hepatitis B virus (HBV) carriers. A modest estimate would put the number of deaths occurring due to HBV infection per year in India to around 100,000. To prevent transmission and progression of the disease, proper community awareness including prevention is necessary. Therefore, this study aims to study the knowledge awareness among the healthy population about hepatitis B including knowledge regarding vaccine. A community-based cross-sectional study was undertaken in two districts of Gujarat. Cluster sampling (30 clusters) was used, and pretested questionnaire was administered to 600 (with a prevalence rate of 5% in Gujarat having design effect of 2 within 95% confidence interval and 10% nonrespondent) healthy individuals, who heard about hepatitis B. Data handled and analyzed in EpiData Analysis V2.2.2.183. Majority of the participants knew about symptoms whereas only 41% knew about prevention methods and few 34% knew about the mode of transmission. Although 40% sample has knowledge about the availability of vaccination, only 20% were self-vaccinated. The common reason for nonvaccination was lack of awareness. Only one-third of the populations in study districts are aware about hepatitis B and its vaccine. Less than one-fifth of the populations are vaccinated for hepatitis B. Important knowledge deficits about the routes of hepatitis B transmission/prevention were identified. Continued efforts should be made to develop and implement hepatitis B educational campaigns/health promotion for these communities.

  7. Knowledge of hepatitis B among healthy population: A community-based survey from two districts of Gujarat, India

    Directory of Open Access Journals (Sweden)

    Sandul Yasobant

    2017-01-01

    Full Text Available Background: Hepatitis B is the world's most common blood-borne viral infection, accounting for 2 billion infections, 350 million carriers, and 6 lakh deaths annually. Country like India still harbors approximately 30–60 million hepatitis B virus (HBV carriers. A modest estimate would put the number of deaths occurring due to HBV infection per year in India to around 100,000. To prevent transmission and progression of the disease, proper community awareness including prevention is necessary. Therefore, this study aims to study the knowledge awareness among the healthy population about hepatitis B including knowledge regarding vaccine. Methodology: A community-based cross-sectional study was undertaken in two districts of Gujarat. Cluster sampling (30 clusters was used, and pretested questionnaire was administered to 600 (with a prevalence rate of 5% in Gujarat having design effect of 2 within 95% confidence interval and 10% nonrespondent healthy individuals, who heard about hepatitis B. Data handled and analyzed in EpiData Analysis V2.2.2.183. Results: Majority of the participants knew about symptoms whereas only 41% knew about prevention methods and few 34% knew about the mode of transmission. Although 40% sample has knowledge about the availability of vaccination, only 20% were self-vaccinated. The common reason for nonvaccination was lack of awareness. Conclusions: Only one-third of the populations in study districts are aware about hepatitis B and its vaccine. Less than one-fifth of the populations are vaccinated for hepatitis B. Important knowledge deficits about the routes of hepatitis B transmission/prevention were identified. Continued efforts should be made to develop and implement hepatitis B educational campaigns/health promotion for these communities.

  8. Cardiovascular health among healthy population of Northeast region of India: a cross-sectional study comparing urban-tribal difference.

    Science.gov (United States)

    Saha, Soma; Gupta, Kinnari; Kumar, Soumitra

    2013-12-01

    Cardiovascular disease is the leading cause of adult mortality in India but data on the prevalence of cardiovascular risk factors are scarce, especially from North-east region of India. This study aims to assess the prevalence and the urban/tribal gradient of cardiovascular disease risk factors among healthy population of Tripura. A cross-sectional study was carried out among 238 healthy individuals (140 urban and 98 tribal) in one urban and five tribal areas of Tripura. Data was collected on sociodemographic profile, medical history, anthropometry, dietary patterns and addiction. Fasting blood samples were collected for biochemical analysis. Prevalence of cardiovascular disease risk factors and short-term cardiovascular disease risk score was calculated. The association of independent variables with 10-year cardiovascular disease risk score were examined by using multiple regression model. Prevalence of obesity, hypertension, diabetes, dyslipidaemia, metabolic syndrome and short-term cardiovascular disease risk score were higher in urban group. Urban people had higher salt, calories and fat intake. No difference was found in the addiction patterns of tobacco and alcohol but frequency and quantity being higher in tribal area. Dyslipidaemia and alcohol consumption showed significant positive association with 10-year cardiovascular disease risk score in both groups. While the non-sedentary lifestyle and dietary habits (low salt, low fat, carbohydrate predominant) of tribal population need to be promoted as a whole across the nation, they need to be protected from the adverse effects of rampant prevalence of tobacco and alcohol addiction among them. Urban population need to be extricated from adverse effects of sedentary lifestyle, modern food habits (high salt, high fat) and tobacco-alcohol addiction.

  9. Russian translations for Cochrane.

    Science.gov (United States)

    Yudina, E V; Ziganshina, L E

    2015-01-01

    Cochrane collaboration has made a huge contribution to the development of evidence-based medicine; Cochrane work is the international gold standard of independent, credible and reliable high-quality information in medicine. Over the past 20 years the Cochrane Collaboration helped transforming decision-making in health and reforming it significantly, saving lives and contributing to longevity [1]. Until recently, Cochrane evidence were available only in English, which represents a significant barrier to their wider use in non-English speaking countries. To provide access to evidence, obtained from Cochrane Reviews, for health professionals and general public (from non-English-speaking countries), bypassing language barriers, Cochrane collaboration in 2014 initiated an international project of translating Plain language summaries of Cochrane Reviews into other languages [2, 3]. Russian translations of Plain language summaries were started in May 2014 by the team from Kazan Federal University (Department of Basic and Clinical Pharmacology; 2014-2015 as an Affiliated Centre in Tatarstan of the Nordic Cochrane Centre, since August 2015 as Cochrane Russia, a Russian branch of Cochrane Nordic, Head - Liliya Eugenevna Ziganshina) on a voluntary basis. To assess the quality of Russian translations of Cochrane Plain Language Summaries (PLS) and their potential impact on the Russian speaking community through user feedback with the overarching aim of furthering the translations project. We conducted the continuous online survey via Google Docs. We invited respondents through the electronic Russian language discussion forum on Essential Medicines (E-lek), links to survey on the Russian Cochrane.org website, invitations to Cochrane contributors registered in Archie from potential Russian-speaking countries. We set up the survey in Russian and English. The respondents were asked to respond to the questionnaire regarding the relevance and potential impact of the Cochrane Russian

  10. Population-based metabolic syndrome risk score and its determinants: The Isfahan Healthy Heart Program

    Directory of Open Access Journals (Sweden)

    Mohsen Hosseini

    2014-01-01

    Full Text Available Background: Metabolic syndrome (MetSy, an important predisposing factor for the most of noncommunicable diseases, has become a global pandemic. Given different definitions used for the MetSy, recently using a score termed "continuous MetSy risk score (CMetSyS" is recommended. The aim of this study was to provide a CMetSyS in a population-based sample of Iranian adults and to assess its determinants. Materials and Methods: We used the data of the baseline survey of a community trial entitled "the Isfahan health heart program." The MetSy was defined according to the Revised National Cholesterol Education Program Third Adult Treatment Panel. All probable predictive models and their predictive performance were provided using leave-one-out cross-validated logistic regression and the receiver operation characteristic curve methods. Multiple linear regression was performed to assess factors associated with the CMetSyS. Results: The study population consisted of 8313 persons (49.9% male, mean age 38.54 ± 15.86 years. The MetSy was documented in 1539 persons (21.86%. Triglycerides and waist circumference were the best predictive components, and fasting plasma glucose had the lowest area under curve (AUC. The AUC for our best model was 95.36 (94.83-95.83%. The best predictive cutoff for this risk score was −1.151 with 89% sensitivity and 87.93% specificity. Conclusion: We provided four population-based leave-one-out cross-validated risk score models, with moderate to perfect predictive performance to identify the MetSy in Iranian adults. The CMetSyS had significant associations with high sensitive C-reactive protein, body mass index, leisure time, and workplace physical activity as well as age and gender.

  11. Seasonal variation of mood and behaviour in a healthy middle-aged population in Japan.

    Science.gov (United States)

    Okawa, M; Shirakawa, S; Uchiyama, M; Oguri, M; Kohsaka, M; Mishima, K; Sakamoto, K; Inoue, H; Kamei, K; Takahashi, K

    1996-10-01

    A population survey of seasonality in six representative cities in Japan was conducted using the Japanese version of the Seasonal Pattern Assessment Questionnaire (SPAQ). The questionnaires were given to 951 parents (male: female ratio 1:1 age range 34-59 years) of high-school students. Significant regional differences in seasonal variations of mood, length of sleep, and weight were observed; the proportion of individuals reporting high seasonality in the two northern cities was significantly higher than that in the other areas. These results provide evidence for a northern predominance in the prevalence of seasonal affective disorder in Japan.

  12. Population pharmacokinetics of oxcarbazepine and its metabolite 10-hydroxycarbazepine in healthy subjects.

    Science.gov (United States)

    Antunes, Natalicia de Jesus; van Dijkman, Sven C; Lanchote, Vera Lucia; Wichert-Ana, Lauro; Coelho, Eduardo Barbosa; Alexandre Junior, Veriano; Takayanagui, Osvaldo Massaiti; Tozatto, Eduardo; van Hasselt, J G Coen; Della Pasqua, Oscar

    2017-11-15

    Oxcarbazepine is indicated for the treatment of partial or generalised tonic-clonic seizures. Most of the absorbed oxcarbazepine is converted into its active metabolite, 10-hydroxycarbazepine (MHD), which can exist as R-(-)- and S-(+)-MHD enantiomers. Here we describe the influence of the P-glycoprotein (P-gp) inhibitor verapamil, on the disposition of oxcarbazepine and MHD enantiomers, both of which are P-gp substrates. Healthy subjects (n=12) were randomised to oxcarbazepine or oxcarbazepine combined with verapamil at doses of 300mg b.i.d. and 80mg t.i.d., respectively. Blood samples (n=185) were collected over a period of 12h post oxcarbazepine dose. An integrated PK model was developed using nonlinear mixed effects modelling using a meta-analytical approach. The pharmacokinetics of oxcarbazepine was described by a two-compartment model with absorption transit compartments and first-order elimination. The concentration-time profiles of both MHD enantiomers were characterised by a one-compartment distribution model. Clearance estimates (95% CI) were 84.9L/h (69.5-100.3) for oxcarbazepine and 2.0L/h (1.9-2.1) for both MHD enantiomers. The volume of distribution was much larger for oxcarbazepine (131L (97-165)) as compared to R-(-)- and S-(+)-MHD (23.6L (14.4-32.8) vs. 31.7L (22.5-40.9), respectively). Co-administration of verapamil resulted in a modest increase of the apparent bioavailability of oxcarbazepine by 12% (10-28), but did not affect parent or metabolite clearances. Despite the evidence of comparable systemic levels of OXC and MHD following administration of verapamil, differences in brain exposure to both moieties cannot be excluded after P-glycoprotein inhibition. Copyright © 2017. Published by Elsevier B.V.

  13. The New Russian Book

    DEFF Research Database (Denmark)

    Pristed, Birgitte Beck

    This book takes up the obtrusive problem of visual representation of fiction in contemporary Russian book design. By analyzing a broad variety of book covers, the study offers an absolutely unique material that illustrates a radically changing notion of literature in the transformation of Soviet ...... the fields of Russian studies, contemporary book and media history, art, design, and visual studies.......This book takes up the obtrusive problem of visual representation of fiction in contemporary Russian book design. By analyzing a broad variety of book covers, the study offers an absolutely unique material that illustrates a radically changing notion of literature in the transformation of Soviet...... print culture to a post-Soviet book market. It delivers a profound and critical exploration of Russian visual imaginary of classic, popular, and contemporary prose. Among all the carelessly bungled covers of mass-published post-Soviet series the study identifies gems from experimental designers...

  14. Russian separation program

    International Nuclear Information System (INIS)

    Rea, J.L.

    1993-01-01

    A small contract signed in FY92 with the Khlopin Radium Institute marked the beginning of the Russian Separations program. Under this contract the Khlopin Radium Institute performed laboratory and dynamic hot-cell testing using cobalt dicarbollide technology on simulated radioactive wastes similar to those found at DOE sites in the United States. The current scope of investigation has been extended to identify prospective technologies for application to other United States needs. The Khlopin Radium Institute project served as a model for three other pilot scale technology development projects. The premise of the pilot scale projects is to enable Russian scientists to demonstrate their technology in the context of DOE needs, using Russian technical expertise has proven to be a cost-effective means of screening Russian technologies

  15. Ethnicity, social disadvantage and psychotic-like experiences in a healthy population based sample.

    Science.gov (United States)

    Morgan, C; Fisher, H; Hutchinson, G; Kirkbride, J; Craig, T K; Morgan, K; Dazzan, P; Boydell, J; Doody, G A; Jones, P B; Murray, R M; Leff, J; Fearon, P

    2009-03-01

    We sought to investigate the prevalence and social correlates of psychotic-like experiences in a general population sample of Black and White British subjects. Data were collected from randomly selected community control subjects, recruited as part of the AESOP study, a three-centre population based study of first-episode psychosis. The proportion of subjects reporting one or more psychotic-like experience was 19% (n = 72/372). These were more common in Black Caribbean (OR 2.08) and Black African subjects (OR 4.59), compared with White British. In addition, a number of indicators of childhood and adult disadvantage were associated with psychotic-like experiences. When these variables were simultaneously entered into a regression model, Black African ethnicity, concentrated adult disadvantage, and separation from parents retained a significant effect. The higher prevalence of psychotic-like experiences in the Black Caribbean, but not Black African, group was explained by high levels of social disadvantage over the life course.

  16. The Incidence and gastrointestinal infectious risk of functional gastrointestinal disorders in a healthy US adult population.

    Science.gov (United States)

    Porter, Chad K; Gormley, Robert; Tribble, David R; Cash, Brooks D; Riddle, Mark S

    2011-01-01

    Functional gastrointestinal disorders (FGDs) are recognized sequelae of infectious gastroenteritis (IGE). Within the active duty military population, a group with known high IGE rates, the population-based incidence, risk factors, and attributable burden of care referable to FGD after IGE are poorly defined. Using electronic medical encounter data (1999-2007) on active duty US military, a matched, case-control study describing the epidemiology and risk determinants of FGD (irritable bowel syndrome (IBS), functional constipation (FC), functional diarrhea (FD), dyspepsia (D)) was conducted. Incidence rates and duration of FGD-related medical care were estimated, and conditional logistic regression was utilized to evaluate FGD risk after IGE. A total of 31,866 cases of FGD identified were distributed as follows: FC 55% (n=17,538), D 21.2% (n=6,750), FD 2.1% (n=674), IBS 28.5% (n=9,091). Previous IGE episodes were distributed as follows: specific bacterial pathogen (n=65, 1.2%), bacterial, with no pathogen specified (n=2155, 38.9%), protozoal (n=38, 0.7%), viral (n=3431, 61.9%). A significant association between IGE and all FGD (odds ratio (OR) 2.64; Phigh risk for IGE. When considering effective countermeasures and mitigation strategies, attention directed toward prevention as well as the acute and chronic sequelae of these infections is needed.

  17. Countering Russian Active Measures

    Science.gov (United States)

    2018-04-16

    information laundering has proven effective in several occasions.20 In 2016, Russian social media actors circulated a fake news story about the...Soviet Union, individuals in positions of power funneled communist party financial resources to off-shore bank accounts and later used this money to...international offshore banking industry, they [the current oligarchs] stole money that belonged to the Russian state, took it abroad for safety

  18. The New Russian Nationalism

    OpenAIRE

    Kolstø, Pal; Blakkisrud, Helge

    2016-01-01

    Assessing the transformation of Russian nationalist discourse in the 21st century Russian nationalism, previously dominated by ‘imperial’ tendencies – pride in a large, strong and multi-ethnic state able to project its influence abroad – is increasingly focused on ethnic issues. This new ethno-nationalism has come in various guises, like racism and xenophobia, but also in a new intellectual movement of ‘national democracy’ deliberately seeking to emulate conservative West European nationalism...

  19. Russian Language Classes

    CERN Multimedia

    2008-01-01

    The Russian Cultural Circle is organising a new Russian course for beginners and will continue its course for advanced students (3rd year), both from September onwards. Anyone interested in taking part is invited to contact Mrs M. Mikhailova (e-mail: mailto:mmmacha@hotmail.com or tel. 022 788 27 53) or Mrs C. Kukowka (e-mail: mailto:christinekukowka@orange.fror tel. ++ 33 4 50 42 43 22 after 8.00 p.m.).

  20. [Prevalence of antibodies against Coxiella burnetii in a healthy population in Lanzarote (Canary Islands)].

    Science.gov (United States)

    Pascual Velasco, F; Otero Ferrio, I; Borobio Enciso, M V

    1991-05-01

    The Canary Islands area now appears to be a Q-fever endemic zone, especially the west side (La Palma island). The situation in the eastern islands in unknown. In order to evaluate the seric prevalence of Coxiella burnetii, 100 serum samples that were taken from the adult population of Lanzarote and, following strict criteria, were analysed using a complement fixation test; blood donors and patients who had suffered a recent infection were excluded. The study was carried out during November/1986. Three serum samples were positive, one had titers of 1/8 and the other two showed 1/64. This prevalence rate of residual Coxiella burnetii antibodies in Lanzarote (3%)--despite being low compared to other areas in Spain--together with te recent cases described, confirms the suspicion that the Canary Islands area is indeed a new endemic Q-fever zone.

  1. Hand bone mineral density reference values in a Turkish healthy female population.

    Science.gov (United States)

    Alioglu, Kenan; Dogu, Beril; Sirzai, Hulya; Yilmaz, Figen; Kuran, Banu

    2017-12-01

    In this study we aimed at identifying the bone mineral density (BMD) reference values of hands, according to age, measured by dual-energy X-ray absorptiometry (DEXA) and assessing the correlation of these values with lumbar and femoral BMD values. A total of 403 healthy women aged between 20 and 70 participated in our study. All BMD measurements are performed by DEXA method on both hands, anteroposterior lumbar spine (L2-L4) and right femur (femoral neck, total femur) regions. BMD results of all the patients were divided to 10-year age categories and evaluated in five subgroups in total (20-30 to 61-70). Among the 10-year age categories we found both dominant and non-dominant hand peak bone mass values in the 31-40 years age group (0.423 ± 0.039 g/cm², 0.410 ± 0.043 g/cm², respectively). Statistically significant positive correlation was defined between dominant and non-dominant hand BMD values and L2-L4 spine, femur neck and total femur values (for dominant hand r = 0.636, P = 0.0001; r = 0.645, P = 0.0001; r = 0.623; P = 0.0001; for non-dominant hand r = 0.624, P = 0.0001; r = 0.637, P = 0.0001, r = 0.623, P = 0.0001, respectively). Regarding the relationship of age and menopause with BMD results, a negative statistical relationship was observed among dominant and non-dominant hand, L2-L4 spine, femoral neck and total femur BMD values (P = 0.0001). Our study has provided hand BMD reference values in women aged between 20-70 years; further studies are needed to investigate the role of these values in identifying diseases causing osteoporosis in the hand and in evaluating treatment. © 2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

  2. SCREENING FOR GENETIC CHANGES AND CODON 129 POLYMORPHISM IN PRNP GENE IN HEALTHY SLOVENIAN POPULATION AND SPORADIC CASES OF CREUTZFELDT-JAKOB DISEASE

    Directory of Open Access Journals (Sweden)

    Sava Smerkolj

    2004-11-01

    Full Text Available Background. Prion protein has an important role in development of prion diseases, fatal neurodegenerative disorders. As the codon 129 genotype of the prion protein gene (PRNP is a known susceptibility factor for the diseases, we wanted to determine its distribution in healthy Slovenian population and also in cases of sporadic Creutzfeldt-Jakob disease (sCJD. Furthermore, we wanted to screen the whole gene in order to establish the presence of genetic changes.Methods. We screened 350 DNA samples of healthy blood donors and 12 DNA samples of patients deceased of sCJD. After the amplification and conformation analysis had been done, the gene was sequenced using an automatic sequencer.Results. Methionine homozygotes comprised 46.8% of healthy population, valine homozygotes 12.1% and heterozygotes 41.1%; out of 12 sCJD patients 10 were methionine homozygotes (83.3%, 1 was valine homozygote (8.3% and 1 was heterozygote (8.3%.Found SNPs were combination of codon 76 change (228C > T and codon 84 change (252T > C in a single sample of healthy population, combination of codon 68 change (204T > C and codon 76 change (228C > T in two samples of healthy population and codon 117 change (351A > G in a healthy population sample and in a valine homozygote patient.Conclusions. In comparison to the pooled Caucasian population is genotype M/M frequency slightly increased on account of decreased genotype M/V frequency in healthy Slovenian population, suggesting a little higher risk for acquiring a new variant of CJD (vCJD, because up to date all confirmed vCJD cases except one heterozygote were methionine homozygotes. Codon 129 genotype distribution in sCJD can be described as disease-specific. The absence of pathogenic mutations in sCJD patients confirms the non-familial, sporadic disease form.

  3. DNA methylation changes separate allergic patients from healthy controls and may reflect altered CD4+ T-cell population structure.

    Directory of Open Access Journals (Sweden)

    Colm E Nestor

    2014-01-01

    Full Text Available Altered DNA methylation patterns in CD4(+ T-cells indicate the importance of epigenetic mechanisms in inflammatory diseases. However, the identification of these alterations is complicated by the heterogeneity of most inflammatory diseases. Seasonal allergic rhinitis (SAR is an optimal disease model for the study of DNA methylation because of its well-defined phenotype and etiology. We generated genome-wide DNA methylation (N(patients = 8, N(controls = 8 and gene expression (N(patients = 9, Ncontrols = 10 profiles of CD4(+ T-cells from SAR patients and healthy controls using Illumina's HumanMethylation450 and HT-12 microarrays, respectively. DNA methylation profiles clearly and robustly distinguished SAR patients from controls, during and outside the pollen season. In agreement with previously published studies, gene expression profiles of the same samples failed to separate patients and controls. Separation by methylation (N(patients = 12, N(controls = 12, but not by gene expression (N(patients = 21, N(controls = 21 was also observed in an in vitro model system in which purified PBMCs from patients and healthy controls were challenged with allergen. We observed changes in the proportions of memory T-cell populations between patients (N(patients = 35 and controls (N(controls = 12, which could explain the observed difference in DNA methylation. Our data highlight the potential of epigenomics in the stratification of immune disease and represents the first successful molecular classification of SAR using CD4(+ T cells.

  4. Hypovitaminosis D in a healthy female population, aged from 40 to 85 years, in the west of Ireland.

    LENUS (Irish Health Repository)

    Lardner, E

    2012-01-31

    BACKGROUND: Increasing attention has been focused on diseases associated with ageing, as the mean age of the population in developed countries increases. Vitamin D and parathyroid hormone play key roles in calcium homeostasis, which is integral to skeletal health. AIMS: To assess the vitamin D status of healthy, community dwelling, middle-aged and older females. METHODS: General biochemistry and bone profiles, including ALP, PTH and 25(OH)D, were determined. RESULTS: Of 143 healthy white women receiving no supplementation or bone modifying treatments, 47% were vitamin D insufficient (<50 nmol\\/L) and only 4% were sufficient for the time of year. There was no statically significant correlation between age and 25(OH)D concentrations; neither was there a statistically significant seasonal variation in 25(OH)D levels noted. CONCLUSION: Vitamin D status should be assessed more often in middle-aged and older females. Expected age-related and seasonal variations in 25(OH)D levels were not confirmed in this study.

  5. 'Aussie normals': an a priori study to develop clinical chemistry reference intervals in a healthy Australian population.

    Science.gov (United States)

    Koerbin, G; Cavanaugh, J A; Potter, J M; Abhayaratna, W P; West, N P; Glasgow, N; Hawkins, C; Armbruster, D; Oakman, C; Hickman, P E

    2015-02-01

    Development of reference intervals is difficult, time consuming, expensive and beyond the scope of most laboratories. The Aussie Normals study is a direct a priori study to determine reference intervals in healthy Australian adults. All volunteers completed a health and lifestyle questionnaire and exclusion was based on conditions such as pregnancy, diabetes, renal or cardiovascular disease. Up to 91 biochemical analyses were undertaken on a variety of analytical platforms using serum samples collected from 1856 volunteers. We report on our findings for 40 of these analytes and two calculated parameters performed on the Abbott ARCHITECTci8200/ci16200 analysers. Not all samples were analysed for all assays due to volume requirements or assay/instrument availability. Results with elevated interference indices and those deemed unsuitable after clinical evaluation were removed from the database. Reference intervals were partitioned based on the method of Harris and Boyd into three scenarios, combined gender, males and females and age and gender. We have performed a detailed reference interval study on a healthy Australian population considering the effects of sex, age and body mass. These reference intervals may be adapted to other manufacturer's analytical methods using method transference.

  6. The Williams syndrome prosociality gene GTF2I mediates oxytocin reactivity and social anxiety in a healthy population.

    Science.gov (United States)

    Procyshyn, Tanya L; Spence, Jason; Read, Silven; Watson, Neil V; Crespi, Bernard J

    2017-04-01

    The neurohormone oxytocin plays a central role in human social behaviour and cognition, and oxytocin dysregulation may contribute to psychiatric disorders. However, genetic factors influencing individual variation in the oxytocinergic system remain poorly understood. We genotyped 169 healthy adults for a functional polymorphism in GTF2I ( general transcription factor II-I ), a gene associated with high prosociality and reduced social anxiety in Williams syndrome, a condition reported to involve high oxytocin levels and reactivity. Participants' salivary oxytocin levels were measured before and after watching a validated empathy-inducing video. Oxytocin reactivity, defined as pre- to post-video percentage change in salivary oxytocin, varied substantially and significantly between individuals with different GTF2I genotypes, with, additionally, a trend towards an interaction between genotype and sex. Individuals with more oxytocin-reactive genotypes also reported significantly lower social anxiety. These findings suggest a model whereby GTF2I has a continuum of effects on human sociality, from the extreme social phenotypes and oxytocin dysregulation associated with gene deletion in Williams syndrome, to individual differences in oxytocin reactivity and sociality associated with common polymorphisms in healthy populations. © 2017 The Author(s).

  7. Factors independently associated with cardiac troponin I levels in young and healthy adults from the general population.

    Science.gov (United States)

    Bossard, Matthias; Thériault, Sébastien; Aeschbacher, Stefanie; Schoen, Tobias; Kunz, Seraina; von Rotz, Mirco; Estis, Joel; Todd, John; Risch, Martin; Mueller, Christian; Risch, Lorenz; Paré, Guillaume; Conen, David

    2017-02-01

    Determinants of cardiomyocyte injury as quantified by high-sensitivity cardiac troponin I (cTnI) in young and healthy individuals, and sex-specific 99th percentiles are largely unknown. Our study included 2077 adults from the general population aged 25-41 years without cardiovascular disease. cTnI was measured using a high-sensitivity assay. We performed stepwise backward linear regression analyses to identify variables independently associated with hs-cTnI levels, and calculated narrow-sense heritability from 1638-genotyped participants. Median age was 37 years. cTnI was quantifiable in all but 11 participants (99.5 %). Median (interquartile range) cTnI was significantly higher in men than in women [0.99 (0.71; 1.65) versus 0.47 (0.33; 0.71) ng/L, p age, systolic blood pressure, heart rate, left ventricular mass, N-terminal pro B-type natriuretic peptide, and creatine kinase (all p age, and systolic blood pressure belong to the strongest determinants of hs-cTnI in healthy adults. The 99th percentile was three times higher in men compared to women. Hence, sex-specific cut-off values may be preferable when applying hs-cTnI for screening purposes. Our results may also improve the interpretation of cTn levels in daily clinical practice.

  8. Healthy Food Intake Index (HFII – Validity and reproducibility in a gestational-diabetes-risk population

    Directory of Open Access Journals (Sweden)

    Jelena Meinilä

    2016-07-01

    Full Text Available Abstract Background The aim was to develop and validate a food-based diet quality index for measuring adherence to the Nordic Nutrition Recommendations (NNR in a pregnant population with high risk of gestational diabetes (GDM. Methods This study is a part of the Finnish Gestational Diabetes Prevention Study (RADIEL, a lifestyle intervention conducted between 2008 and 2014. The 443 pregnant participants (61 % of those invited, were either obese or had a history of GDM. Food frequency questionnaires collected at 1st trimester served for composing the HFII; a sum of 11 food groups (available score range 0–17 with higher scores reflecting higher adherence to the NNR. Results The average HFII of the participants was 10.2 (SD 2.8, range 2–17. Factor analysis for the HFII component matrix revealed three factors that explained most of the distribution (59 % of the HFII. As an evidence of the component relevance 9 out of 11 of the HFII components independently contributed to the total score (item-rest correlation coefficients <0.31. Saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, sucrose, and fiber intakes (among other nutrients showed linearity across the HFII categories (P ≤ 0.030 for all nutrients tested; the higher the HFII, the closer the nutrient intake to the recommended intake level. Educational attainment (P = 0.0045, BMI (P = 0.0098, smoking (P = 0.007, and leisure time physical exercise (P = 0.038 showed linearity across the HFII categories. Intra-class correlation coefficient for the HFII was 0.85 (CI 0.79, 0.90. Conclusions The HFII components reflect the food guidelines of the NNR, intakes of relevant nutrients, and characteristics known to vary with diet quality. It largely ignores energy intake, its components have independent contribution to the HFII, and it exhibits reproducibility. The main shortcomings are absence of red and processed meat component, and the validation in a

  9. Relationship Between Neck Circumference and Epicardial Fat Thickness in a Healthy Male Population.

    Science.gov (United States)

    Küçük, Uğur; Küçük, Hilal Olgun; Cüce, Ferhat; Balta, Sevket

    2016-09-01

    Epicardial fat is an upper body visceral fat depot that may play a significant role in the development of adverse metabolic and cardiovascular risk profiles. There is a significant direct relationship between the amount of epicardial fat and general body adiposity (body mass index, BMI), but data regarding subcutaneous adiposity is limited. We conducted a study to determine the association between neck circumference and epicardial fat thickness in healthy young male individuals, and assess their individual correlations with general body adiposity and cardiometabolic risk factors. One hundred consecutive male patients aged 18 years or older with no known major medical conditions were included in the study. All participants underwent detailed physical examination including measurement of blood pressure, weight, height, waist/hip ratio, and neck circumference. Blood was collected to determine fasting glucose and lipid parameters. A standard echocardiographic examination was performed with additional epicardial fat thickness determination. Among 100 study participants, neck circumference correlated significantly with weight, waist circumference, BMI, blood glucose, serum total cholesterol, low-density (LDL)-cholesterol, and triglycerides levels. No significant correlation was found between neck circumference and high-density lipoprotein (HDL)-cholesterol levels. Neck circumference correlated moderately and positively with echocardiographic epicardial fat thickness. Among patients with low cardiometabolic risk, increased neck circumference was associated with increased epicardial fat thickness. A gordura epicárdica é um depósito de gordura visceral na parte superior do organismo que pode desempenhar um papel importante no desenvolvimento de perfis cardiovasculares e metabólicos adversos. Há uma relação direta significativa entre a quantidade de gordura epicárdica e a adiposidade corporal geral (índice de massa corporal, IMC), mas dados sobre a adiposidade

  10. Social support for healthy eating: development and validation of a questionnaire for the French-Canadian population.

    Science.gov (United States)

    Carbonneau, Elise; Bradette-Laplante, Maude; Lamarche, Benoît; Provencher, Véronique; Bégin, Catherine; Robitaille, Julie; Desroches, Sophie; Vohl, Marie-Claude; Corneau, Louise; Lemieux, Simone

    2018-05-28

    The present study aimed to develop and validate a questionnaire assessing social support for healthy eating in a French-Canadian population. A twenty-one-item questionnaire was developed. For each item, participants were asked to rate the frequency, in the past month, with which the actions described had been done by family and friends in two different environments: (i) at home and (ii) outside of home. The content was evaluated by an expert panel. A validation study sample was recruited and completed the questionnaire twice. Exploratory factor analysis was performed on items to assess the number of subscales. Internal consistency reliability was assessed using Cronbach's ɑ. Test-retest reliability was evaluated with intraclass correlations between scores of the two completions. Online survey. Men and women from the Québec City area (n 150). The content validity assessment led to a few changes, resulting in a twenty-two-item questionnaire. Exploratory factor analysis revealed a two-factor structure for both environments, resulting in four subscales: supportive actions at home; non-supportive actions at home; supportive actions outside of home; and non-supportive actions outside of home. Two items were removed from the questionnaire due to low loadings. The four subscales were found to be reliable (Cronbach's ɑ=0·82-0·94; test-retest intraclass correlation=0·51-0·70). The Social Support for Healthy Eating Questionnaire was developed for a French-Canadian population and demonstrated good psychometric properties. This questionnaire will be useful to explore the role of social support and its interactions with other factors in predicting eating behaviours.

  11. Genetic polymorphisms in homologous recombination repair genes in healthy Slovenian population and their influence on DNA damage

    International Nuclear Information System (INIS)

    Goricar, Katja; Erculj, Nina; Zadel, Maja; Dolzan, Vita

    2012-01-01

    Homologous recombination (HR) repair is an important mechanism involved in repairing double-strand breaks in DNA and for maintaining genomic stability. Polymorphisms in genes coding for enzymes involved in this pathway may influence the capacity for DNA repair. The aim of this study was to select tag single nucleotide polymorphisms (SNPs) in specific genes involved in HR repair, to determine their allele frequencies in a healthy Slovenian population and their influence on DNA damage detected with comet assay. In total 373 individuals were genotyped for nine tag SNPs in three genes: XRCC3 722C>T, XRCC3 -316A>G, RAD51 -98G>C, RAD51 -61G>T, RAD51 1522T>G, NBS1 553G>C, NBS1 1197A>G, NBS1 37117C>T and NBS1 3474A>C using competitive allele-specific amplification (KASPar assay). Comet assay was performed in a subgroup of 26 individuals to determine the influence of selected SNPs on DNA damage. We observed that age significantly affected genotype frequencies distribution of XRCC3 -316A>G (P = 0.039) in healthy male blood donors. XRCC3 722C>T (P = 0.005), RAD51 -61G>T (P = 0.023) and NBS1 553G>C (P = 0.008) had a statistically significant influence on DNA damage. XRCC3 722C>T, RAD51 -61G>T and NBS1 553G>C polymorphisms significantly affect the repair of damaged DNA and may be of clinical importance as they are common in Slovenian population

  12. Population trends and public awareness of healthy and pathological ageing in India: A brief overview.

    Science.gov (United States)

    Loganathan, Santosh; Iyengar, Vijeth; Chowdappa, Suresh Vedalaveni; Varghese, Mathew

    2017-10-01

    India is poised to experience dramatic shifts in the age and makeup of its population. Specifically, projections havehighlighted an increase in both the percentage of the elderly and those suffering from dementia-related disorders.Previous studies have examined the demographics of aging, its impact on the healthcare infrastructure and recommended policies to better cater to the elderly. This article focuses on a summary of these findings in relation to key stakeholders in the care of the elderly including mental health professionals, family caregivers, and public health officials. We broadly conclude that there exists a general shallow level of understanding of what constitutes pathological aging (i.e. dementia) across all stakeholders, and this creates a cascade of effects including delays in treatment seeking and barriers in conducting and having accurate demographic studies. Moreover, addressing this knowledge gap can help enhance communication between these three stakeholders in the hopes of the following: (a) increased education and awareness, (b) faster seeking of care, and (c) earlier diagnoses leading to better opportunities to collect accurate demographics of those suffering from dementia-related disorders. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Population pharmacokinetic/ pharmacodynamic modelling of eltrombopag in healthy volunteers and subjects with chronic liver disease

    Science.gov (United States)

    Farrell, Colm; Hayes, Siobhan C; Wire, Mary; Zhang, Jianping

    2014-01-01

    Aims To characterize the pharmacokinetics (PK)/pharmacodynamics (PD) of eltrombopag in chronic liver disease (CLD). Methods The PK/PD model was developed using data from 79 CLD patients using nonlinear mixed-effects modelling. Results The PK of eltrombopag were described by a two-compartment model with dual sequential first-order absorption. Gender, race and severity of CLD were predictors of the apparent clearance of eltrombopag. The PD of eltrombopag in CLD were adequately described by a four-compartment lifespan model, in which eltrombopag stimulated platelet precursor production rate. East Asian CLD patients were less sensitive to the stimulatory effect of eltrombopag. Following a daily dose regimen of 50 mg eltrombopag, the time to achieve peak platelet counts was longer for the CLD population compared with patients who had immune thrombocytopenic purpura, but was comparable to patients with hepatitis C. Likewise, it took a longer time for platelet counts to rebound back to baseline once eltrombopag treatment was discontinued. Conclusions The time course of the platelet response in CLD was different from that in immune thrombocytopenic purpura but comparable to that in hepatitis C. PMID:24117976

  14. A graphical method for comparing nocturnal oxygen saturation profiles in individuals and populations: Application to healthy infants and preterm neonates.

    Science.gov (United States)

    Terrill, Philip I; Dakin, Carolyn; Edwards, Bradley A; Wilson, Stephen J; MacLean, Joanna E

    2018-05-01

    Pulse-oximetry (SpO 2 ) allows the identification of important clinical physiology. However, summary statistics such as mean values and desaturation incidence do not capture the complexity of the information contained within continuous recordings. The aim of this study was to develop an objective method to quantify important SpO 2 characteristics; and assess its utility in healthy infant and preterm neonate cohorts. An algorithm was developed to calculate the desaturation incidence, depth, and duration. These variables are presented using three plots: SpO 2 cumulative-frequency relationship; desaturation-depth versus incidence; desaturation-duration versus incidence. This method was applied to two populations who underwent nocturnal pulse-oximetry: (1) thirty-four healthy term infants studied at 2-weeks, 3, 6, 12, and 24-months of age and (2) thirty-seven neonates born <26 weeks and studied at discharge from NICU (37-44 weeks post-conceptual age). The maturation in healthy infants was characterized by reduced desaturation index (27.2/h vs 3.3/h at 2-weeks and 24-months, P < 0.01), and increased percentage of desaturation events ≥6-s in duration (27.8% vs 43.2% at 2-weeks and 3-months, P < 0.01). Compared with term-infants, preterm infants had a greater desaturation incidence (54.8/h vs 27.2/h, P < 0.01), and these desaturations were deeper (52.9% vs 37.6% were ≥6% below baseline, P < 0.01). The incidence of longer desaturations (≥14-s) in preterm infants was correlated with healthcare utilization over the first 24-months (r = 0.63, P < 0.01). This tool allows the objective comparison of extended oximetry recordings between groups and for individuals; and serves as a basis for the development of reference ranges for populations. © 2018 Wiley Periodicals, Inc.

  15. Frequency of colorectal cancer in healthy individual's relatives: A cross-sectional population-based study

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Zali

    2011-10-01

    Full Text Available Introduction: Family history of colorectal cancer has been shown to be related to the risk of developing colorectal cancer. This risk depends on the number of affected relatives and the age at diagnosis. In this study we aimed to estimate the frequency of a positive family history of colorectal cancer in a random sample from Tehran population. Materials and Methods: This study was a community-based cross-sectional survey conducted from May 2006 to December 2007 in Tehran province, Iran. A total of 5,500 peoples (age≥20 years drawn up randomly by random sampling according to postal codes and invited to participate in the study. All participants completed a detailed health data registry form on family history status of colorectal cancer. Results: The mean age of men with a positive family history was significantly different from men with negative family history. There was no significant difference between mean age of women responders with or without positive family history. Among all participants (n=5,500, 162 responders (2.9% had a history of colorectal cancer. Of 162, 67 responders (1.22% had one and 4(0.07% had two or more first-degree relative with colorectal cancer. Of 5,500 participants, 18 subjects (0.33% reported having two or more first-degree relative with colorectal cancer or one first-degree relative with colorectal cancer diagnosed at age <50 years. Four subjects (0.07% had three or more first-degree relative with colorectal cancer. Conclusion: Based on the findings, we estimate that more than 570,000 subjects in the Iran in the age group≥20 years have at least two to three times increased risk of developing colorectal cancer which should be identified and encourage to participate in screening and surveillance protocols of colorectal cancer.

  16. Negative social comparisons and psychosis proneness in a healthy adolescent population.

    Science.gov (United States)

    Cotier, F A; Toulopoulou, T

    2017-10-01

    There is growing evidence of an association between negative social comparisons (NSC) and both psychosis, and psychosis proneness. The majority of the work thus far, however, has focused largely on one type of NSC, namely, social rank. Whilst social rank is clearly an important factor, an individual's perception of belonging is likely also of importance; particularly, when considering individuals from collectivistic cultures such as China, where greater emphasis is placed on fitting into the group. There is also limited research investigating what factors may contribute towards the relationship between NSC and psychosis proneness, and to what extent this relationship may be due to common familial factors. To address these issues, we examined whether (1) Social rank and perceived belonging predict negative, positive and depressive psychotic experiences in a Chinese, adolescent, twin and sibling population, (2) coping styles moderate the impact of these relationships and (3), there is a familial association between NSC and psychosis proneness. Both social rank and perceived belonging were found to predict the negative and depressive dimensions of psychosis. These relationships were moderated by problem-focused coping styles. Interestingly, the association between perception of belonging, and negative psychotic experiences was familial-and stronger in Monozygotic twins-indicating perhaps shared aetiology due to common genes. Our findings highlight NSC as potential vulnerability markers for negative and depressive psychotic experiences, and suggest potentially different aetiological pathways amongst different NSC and different psychotic experiences. On a clinical level, our findings emphasize the need to consider coping styles when treating at-risk individuals. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  17. Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposure.

    Directory of Open Access Journals (Sweden)

    Sophie Roetynck

    Full Text Available Multiparameter flow cytometry has revealed extensive phenotypic and functional heterogeneity of CD4 T cell responses in mice and humans, emphasizing the importance of assessing multiple aspects of the immune response in correlation with infection or vaccination outcome. The aim of this study was to establish and validate reliable and feasible flow cytometry assays, which will allow us to characterize CD4 T cell population in humans in field studies more fully.We developed polychromatic flow cytometry antibody panels for immunophenotyping the major CD4 T cell subsets as well as broadly characterizing the functional profiles of the CD4 T cells in peripheral blood. We then validated these assays by conducting a pilot study comparing CD4 T cell responses in distinct populations of healthy adults living in either rural or urban Kenya. This study revealed that the expression profile of CD4 T cell activation and memory markers differed significantly between African and European donors but was similar amongst African individuals from either rural or urban areas. Adults from rural Kenya had, however, higher frequencies and greater polyfunctionality among cytokine producing CD4 T cells compared to both urban populations, particularly for "Th1" type of response. Finally, endemic exposure to malaria in rural Kenya may have influenced the expansion of few discrete CD4 T cell populations with specific functional signatures.These findings suggest that environmentally driven T cell activation does not drive the dysfunction of CD4 T cells but is rather associated with greater magnitude and quality of CD4 T cell response, indicating that the level or type of microbial exposure and antigenic experience may influence and shape the functionality of CD4 T cell compartment. Our data confirm that it is possible and mandatory to assess multiple functional attributes of CD4 T cell response in the context of infection.

  18. Is exposure to ionising radiation associated with childhood cardiac arrhythmia in the Russian territories contaminated by the Chernobyl fallout? A cross-sectional population-based study.

    Science.gov (United States)

    Jourdain, Jean-Rene; Landon, Geraldine; Clero, Enora; Doroshchenko, Vladimir; Silenok, Aleksandr; Kurnosova, Irina; Butsenin, Andrei; Denjoy, Isabelle; Franck, Didier; Heuze, Jean-Pierre; Gourmelon, Patrick

    2018-03-25

    To investigate childhood cardiac arrhythmia and chronic exposure to caesium-137 ( 137 Cs) resulting from the Chernobyl accident. Prospective cross-sectional study using exposed/unexposed design conducted in the Bryansk region from May 2009 to May 2013 on children selected on the basis of 137 Cs soil deposition: control territories ([ 137 Cs]555 kBq per square metre, where children were considered as exposed). Russian territories affected by the Chernobyl fallout (Bryansk region). This cross-sectional study included 18 152 children aged 2-18 years and living in the Bryansk region (Russia). All children received three medical examinations (ECG, echocardiography and 137 Cs whole-body activity measurement) and some of them were given with a 24-hour Holter monitoring and blood tests. Cardiac arrhythmia was diagnosed in 1172 children living in contaminated territories and 1354 children living in control territories. The crude prevalence estimated to 13.3% in contaminated territories was significantly lower than in control territories with 15.2% over the period 2009-2013 (PChernobyl fallout. The suspected increase of cardiac arrhythmia in children exposed to Chernobyl fallout is not confirmed. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  19. ERIC-PCR fingerprinting-based community DNA hybridization to pinpoint genome-specific fragments as molecular markers to identify and track populations common to healthy human guts.

    Science.gov (United States)

    Wei, Guifang; Pan, Li; Du, Huimin; Chen, Junyi; Zhao, Liping

    2004-10-01

    Bacterial populations common to healthy human guts may play important roles in human health. A new strategy for discovering genomic sequences as markers for these bacteria was developed using Enterobacterial Repetitive Intergenic Consensus (ERIC)-PCR fingerprinting. Structural features within microbial communities are compared with ERIC-PCR followed by DNA hybridization to identify genomic fragments shared by samples from healthy human individuals. ERIC-PCR profiles of fecal samples from 12 diseased or healthy human and piglet subjects demonstrated stable, unique banding patterns for each individual tested. Sequence homology of DNA fragments in bands of identical size was examined between samples by hybridization under high stringency conditions with DIG-labeled ERIC-PCR products derived from the fecal sample of one healthy child. Comparative analysis of the hybridization profiles with the original agarose fingerprints identified three predominant bands as signatures for populations associated with healthy human guts with sizes of 500, 800 and 1000 bp. Clone library profiling of the three bands produced 17 genome fragments, three of which showed high similarity only with regions of the Bacteroides thetaiotaomicron genome, while the remainder were orphan sequences. Association of these sequences with healthy guts was validated by sequence-selective PCR experiments, which showed that a single fragment was present in all 32 healthy humans and 13 healthy piglets tested. Two fragments were present in the healthy human group and in 18 children with non-infectious diarrhea but not in eight children with infectious diarrhea. Genome fragments identified with this novel strategy may be used as genome-specific markers for dynamic monitoring and sequence-guided isolation of functionally important bacterial populations in complex communities such as human gut microflora.

  20. Examination of validity of fall risk assessment items for screening high fall risk elderly among the healthy community-dwelling Japanese population

    OpenAIRE

    DEMURA, Shinichi; SATO, Susumu; YAMAJI, Shunsuke; KASUGA, Kosho; NAGASAWA, Yoshinori

    2010-01-01

    We aimed to examine the validity of fall risk assessment items for the healthy community-dwelling elderly Japanese population. Participants were 1122 healthy elderly individuals aged 60 years and over (380 males and 742 females). The percentage who had experienced a fall was 15.8%. This study used fall experience and 50 fall risk assessment items representing the five risk factors (symptoms of falling, physical function, disease and physical symptom, environment, and behavior and character), ...

  1. Rural Hispanic populations at risk in developing diabetes: sociocultural and familial challenges in promoting a healthy diet.

    Science.gov (United States)

    Heuman, Amy N; Scholl, Juliann C; Wilkinson, Kenton

    2013-01-01

    Type II diabetes affects Hispanic populations disproportionately and is the fifth leading cause of death for Hispanic people in the United States ( Smith & Barnett, 2005 ). Risk of diabetes is of great concern throughout the United States and is clearly of epidemic proportions for regions such as the Southwest and Texas where the primary minority populations are Mexican American. We conducted four focus groups with a total of 49 Hispanic participants (23 adults and 26 adolescents) from rural West Texas communities to gain insights about participants' eating habits, knowledge of diabetes, and potential barriers to preventive care. From the data, we identified a three-tiered predisposition or vulnerability to diabetes-heredity; preferences for unhealthy, culturally based food; and temptations from U.S. mainstream fast food culture. These vulnerabilities added to the sociocultural concerns that participants identified-importance of parental and familial modeling; challenges to healthy eating based on a culturally based diet and mainstream fast food culture; and a lack of support from the larger sociocultural networks such as teachers, community leaders, and the media. From these data, we have a better understanding of familial and sociocultural factors that need to be addressed in the development of preventive public awareness and educational plans. We outline implications for practitioners and educators from an integrated cultural biomedical approach.

  2. Russian nuclear industry exports

    International Nuclear Information System (INIS)

    Gorbatchev, A.

    2016-01-01

    Rosatom is the world leader for the export of nuclear technologies. 34 reactors of Russian technology are being built or planned worldwide. Most reactors proposed by Rosatom are third generation VVER-1200 units with an electric power output of 1200 MWe. Although the nuclear island is always built by Rosatom, the remain of the plant can be subcontracted to other enterprises and European companies are sought because they would bring a european quality touch to Russian works. One of the main assets of Rosatom is to propose an integrated offer from supplying nuclear fuel to managing nuclear waste via the turnkey building of nuclear power plants. Another important asset is the financial assistance of the Russian state through state credit or the support from Russian national banks that appears to be a decisive advantage in the international competition to win markets. We have to temper the Russian export perspectives by noting that most projects are set in countries that are prone to instabilities and that the economic crisis affecting Russia has a negative impact on its financial means. (A.C.)

  3. Public information - Northwest region of Russian Federation

    International Nuclear Information System (INIS)

    Saiapina, A.

    2001-01-01

    Regional Center of Public Information in Northwest region of Russian Federation is a part of the State Regional Educational Center of Ministry of the Russian Federation for atomic energy in St.-Petersburg, Russia (http://graph.runnet.ru/). This Center of Public Information (CPI) provides a wide range of information dealing with the nuclear power. The objectives of the CPI are: to conduct informational and educational activities so as to form a positive attitude toward atomic energy and nuclear technologies; to provide the population with a means reliable information about objects of potential risk; to organize an active exchange of the information with enterprises using nuclear technologies in the region. The main topics of informational support are these: electricity production, the ground of nuclear power, new Russian nuclear reactors, nuclear safety, nuclear power and environment, radioactivity, Leningrad nuclear power plant, responsibilities in nuclear engineering. (author)

  4. Russian desman (Desmana moschata: Talpidae at the edge of disappearance

    Directory of Open Access Journals (Sweden)

    Marina V. Rutovskaya

    2017-05-01

    Full Text Available The population of the Russian desman in all historical areas is currently no more than 8000–10,000 individuals. The estimated population size of the Russian desman is based on direct surveys during 2010–2016. We observed over 266 km of the coastline in eight regions where the desman lives. Since the early 20th century the number of specimens has been steadily declining. In addition to the previously described factors that determine the reduction of the population size, such as land reclamation, the construction of hydroelectric stations and the flourishing of poaching at the end of the last century, the status of the Russian desman population is adversely affected by periodic droughts and the absence of floods. Currently Protected Areas remain as the only passive measure to protect the Russian desman in the absence of a programme to species protection nor state support.

  5. Advanced long-term bird banding and climate data mining in spring confirm passerine population declines for the Northeast Chinese-Russian flyway

    Science.gov (United States)

    Jiao, Shengwu; Huettmann, Falk; Guo, Yumin; Li, Xianda; Ouyang, Yanlan

    2016-09-01

    The migration of birds is fascinating for humans but it's also a serious environmental monitoring and management issue on a global level. Bird banding using mistnets has been the method of choice for decades worldwide; linking these data with climate data allows to infer on global warming and outlier events. However, good methods to achieve this effectively in time and space for many species are still missing; data for Asia are specifically sparse and often 'messy'. Here we present a data mining summary information for data from two bird banding stations (Gaofeng and Qingfeng) along the vast Northeast Chinese-Russian flyway. Bird data were collected during spring 2002-2011 with standardized techniques and then linked with related climate data in the banding as well as the wintering sites. This creates a complex data set which is based on a decade and which includes many predictors. This first-time data mining analysis with 'data cloning' and machine learning methods (boosted regression trees) shows how to extract the major signals in this unique dataset from highly correlated and interacting predictors. Our results indicate a large-scale warming trend for the flyway, with a start in 2003, and a freezing rain outlier event in 2008; the last years remained on a rather warm level. All evidence along this vast flyway supports major changes, warming trends, habitat losses and consequently strong passerine declines. Presumably human pressures are a major factor either way and we propose to address these problems immediately for betterment if meaningful conservation targets are to be met.

  6. [Mycobacterium tuberculosis strain transmission caused by migratory processes in the Russian Federation (in case of populational migration from the Caucasian Region to Moscow and the Moscow Region)].

    Science.gov (United States)

    Andreevskaia, S N; Chernousova, L N; Smirnova, T G; Larionova, E E; Kuz'min, A V

    2006-01-01

    The investigation was carried out on 134 M. tuberculosis isolated from 134 patients treated at the Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences. The patients were divided into 2 groups: 1) those who were natives of Moscow and the Moscow Region (MR patients); 2) those who were migrants to the Moscow Region from Azerbaijan, Daghestan, Chechnya, Ingushetia, Karachai-Cherkessia, North Ossetia (the Caucasian Region) (CR patients) who had fallen in the place of birth. Genotyping by the polymorphism of lengths of the restriction fragments containing the insertion sequence IS6110 revealed a genetic diversity of M. tuberculosis strains. The examined M. tuberculosis strains belonged to 13 genotypic families. The W and AI families were prevalent. The family W M. tuberculosis strains isolated from the Caucasians were highly clustered, as confirmed by the overwhelming predominance of the strain variant W148 (19.7%). The spectrum of the strain variants of the W family, and those of the AI family in particular, greatly differed in MR and CR patients. Only one strain variant AI12 occurring both in MR and CR patients was detected. A study of the transmission activity coefficient (TAC) of the families W and AI indicated that the transmission activity of W strains was significantly higher than that of M. tuberculosis strains of the AI family. A comparative analysis of the TAC of M. tuberculosis strains of the AI family demonstrated that the transmission activity of the strains of this family was identical no matter where a patient had fallen ill (1.59 and 1.41% in the Moscow and Caucasian Regions, respectively). Unlike M. tuberculosis strains of the AI family, the TAC of W strains isolated from the patients infected in the Moscow Region (28.17 and 19.05%, respectively), which suggests the more intensive transmission of the pathogen M. tuberculosis of the W family in the Caucasian Region.

  7. Pattern of Coronary Artery Disease Risk Factors in Population Younger than 55 Years and Above 55 Years: A Population Study of 31999 Healthy Individuals

    Directory of Open Access Journals (Sweden)

    Zinat Nadia Hatmi

    2011-06-01

    Full Text Available More than eighty percent of patients with coronary heart diseases (CHD have conventional risk factors. Prevalence of well known risk factors seems to show a different pattern in younger patients and individual above 55 years. To evaluate the pattern of conventional CHD risk factors in healthy individuals in two different age groups. A large scale population based survey of 31999 individuals from ten medical centers was designed. Screening of risk factors was performed upon these protocols: taking medical history, physical examination and blood tests of complete blood cell counts, fasting blood sugar, lipid profile, urinalysis and creatinine. Prevalence of the risk factors in healthy people aged above 55 years were: 8.1% for systolic blood pressure (SBP>140 mmHg, 3.8% for diastolic blood pressure (DBP>90mmHg, 13.9% for fasting blood glucose (FBS≥126 Mg/dl, 36.9% for total cholesterol>200 Mg/dl, 19.2% for triglyceride (TG>200 Mg/dl, 67.8% for HDL-c130 Mg/dl, 4.72 for TC/HDL-c ratio, 2.88 for LDL-c/HDL/c ratio and 4.24 for TG/HDL-c ratio. Prevalence of risk factors in individuals younger than 55 years were: 1.7% for SBP>140 mmHg, 1.2% for DBP>90 mmHg, 5.2% for FBS≥126 Mg/dl, 31.3% for TC>200 Mg/dl, 21.5% for TG>200 Mg/dl, 69.4% for HDL-c130 Mg/dl, 4.7 for TC/HDL-c ratio, 2.83 for LDL-c/HDL-c ratio and 4.43 for TG/HDL-c ratio. In univariate model of analysis: prevalence of the risk factors were significantly higher in age above 55 years than in people younger than 55 years except for hypertriglyceridemia and HDL-c200 Mg/dl P= 0.002, HDL-c140 mmHg P=0.001. Pattern of such a CHD risk factors of FBS≥126 Mg/dl, TG>200 Mg/dl, HDL-c140 mmHg demonstrated a statistically significant difference in the age above 55 years to the healthy people younger than 55 years. These results cab be implicated to set up prediction models for stratifying individuals at higher risk of CHD.

  8. A Population Pharmacokinetic Model for Disposition in Plasma, Saliva and Urine of Scopolamine after Intranasal Administration to Healthy Human Subjects

    Science.gov (United States)

    Wu, L.; Tam, V. H.; Chow, D. S. L.; Putcha, L.

    2014-01-01

    An intranasal gel formulation of scopolamine (INSCOP) was developed for the treatment of Space Motion Sickness. The bioavailability and pharmacokinetics (PK) were evaluated under the Food and Drug Administration guidelines for clinical trials with an Investigative New Drug (IND) protocol. The aim of this project was to develop a PK model that can predict the relationship between plasma, saliva and urinary scopolamine concentrations using data collected from the IND clinical trials with INSCOP. Methods: Twelve healthy human subjects were administered three dose levels (0.1, 0.2 and 0.4 mg) of INSCOP. Serial blood, saliva and urine samples were collected between 5 min and 24 h after dosing and scopolamine concentrations were measured by using a validated LC-MS-MS assay. Pharmacokinetic Compartmental models, using actual dosing and sampling times, were built using Phoenix (version 1.2). Model selection was based on the likelihood ratio test on the difference of criteria (-2LL) and comparison of the quality of fit plots. Results: The best structural model for INSCOP (minimal -2LL= 502.8) was established. It consisted of one compartment each for plasma, saliva and urine, respectively, which were connected with linear transport processes except the nonlinear PK process from plasma to saliva compartment. The best-fit estimates of PK parameters from individual PK compartmental analysis and Population PK model analysis were shown in Tables 1 and 2, respectively. Conclusion: A population PK model that could predict population and individual PK of scopolamine in plasma, saliva and urine after dosing was developed and validated. Incorporating a non-linear transfer from plasma to saliva compartments resulted in a significantly improved model fitting. The model could be used to predict scopolamine plasma concentrations from salivary and urinary drug levels, allowing non-invasive therapeutic monitoring of scopolamine in space and other remote environments.

  9. Russian Sentence Adverbials

    DEFF Research Database (Denmark)

    Lorentzen, Elena; Durst-Andersen, Per

    2015-01-01

    way or the other to take their starting point in the previous discourse. It is, however, stressed that the specificity of the Russian language is found in modal adverbials where a division between external and internal reality exists. We end the examination by discussing the function of word order......Sentence adverbials (SA) in Russian are analyzed in their totality, i.e. from a lexical, syntactic, semantic and pragmatic point of view. They are classified according to Hare’s three utterance components which yields (1) neustic, (2) tropic and (3) phrastic SAs. These components are used...... to represent semantic paraphrases of Russian SAs in utterances from various types of discourse in order to show their exact contribution to the meaning conveyed by the entire utterance. They are further subdivided according to their function: (1) into connectives and non-connectives; (2) into attitudinal...

  10. Obesity and metabolic features associated with long-term developing diastolic dysfunction in an initially healthy population-based cohort.

    Science.gov (United States)

    Chau, Kénora; Girerd, Nicolas; Magnusson, Martin; Lamiral, Zohra; Bozec, Erwan; Merckle, Ludovic; Leosdottir, Margret; Bachus, Erasmus; Frikha, Zied; Ferreira, João Pedro; Després, Jean-Pierre; Rossignol, Patrick; Boivin, Jean-Marc; Zannad, Faiez

    2018-04-21

    Diastolic dysfunction (DD) is increasingly common. However, its metabolic determinants are poorly known. This study aims to determine which metabolic and inflammatory features predict DD in initially healthy adults. We prospectively analyzed the association between metabolic features and DD in 728 initially healthy adults aged 30-60 from Eastern France enrolled in the STANISLAS population-based cohort. Clinical and biological cardiovascular features were collected at baseline (1994-1995). DD was assessed twenty years later (2011-2016) by echocardiography using current international guidelines. For replication purposes, 1463 subjects from the Malmö Preventive Project cohort were analyzed. In the STANISLAS cohort, 191 subjects (26.2%) developed DD. In age-sex-adjusted logistic models, significant predictors of DD were body mass index (BMI, odds ratio for 1-standard-deviation increase (OR) 1.28, 95% CI 1.08-1.52), waist circumference (WC, OR 1.48, 95% CI 1.18-1.84), waist-hip ratio (OR 1.53, 95% CI 1.16-2.02), systolic blood pressure (OR 1.19, 95% CI 1.00-1.43) and triglycerides (TG, OR 1.18, 95% CI 1.00-1.40). Subjects with elevated WC (> 80th percentile) and TG (> 50th percentile) had a twofold higher DD risk (age-sex-adjusted odds ratio 2.00, 95% CI 1.20-3.31, P = 0.008), whereas no such interplay was observed for BMI. In the Malmö cohort, BMI was similarly associated with DD; participants with both elevated BMI and TG were at higher DD risk (age-sex-adjusted odds ratio 1.61, 95% CI 1.18-2.20, P = 0.002). Subjects with elevated WC and TG may have a higher long-term DD risk. Prevention targeting visceral obesity may help reduce the incidence of DD.

  11. Real T1 relaxation time measurement and diurnal variation analysis of intervertebral discs in a healthy population of 50 volunteers

    International Nuclear Information System (INIS)

    Galley, J.; Maestretti, G.; Koch, G.; Hoogewoud, H-M.

    2017-01-01

    Purpose: To measure the real T1 relaxation time of the lumbar intervertebral discs in a young and healthy population, using different inversion recovery times, and assess diurnal variation. Material and methods: Intervertebral discs from D12 to S1 of 50 healthy volunteers from 18 to 25 years old were evaluated twice the same day, in the morning and in the late afternoon. Dedicated MRI sequences with different inversion recovery times (from 100 to 2500 ms) were used to calculate the real T1 relaxation time. Three regions of interest (ROIs) were defined in each disc, the middle representing the nucleus pulposus (NP) and the outer parts the annulus fibrosus (AF) anterior and posterior. Diurnal variation and differences between each disc level were analyzed. Results: T1 mean values in the NP were 1142 ± 12 ms in the morning and 1085 ± 13 ms in the afternoon, showing a highly significant decrease of 57 ms (p < 0.001). A highly significant difference between the levels of the spine was found. The mean T1 of the anterior part of the AF was 577 ± 9 ms in the morning and 554 ± 8 ms in the afternoon. For the posterior part, the mean values were 633 ± 8 ms in the morning and 581 ± 7 ms in the evening. It shows a highly significant decrease of 23 ms for the anterior part and 51 ms for the posterior part (all p < 0.001). Conclusion: T1 mapping is a promising method of intervertebral disc evaluation. Significant diurnal variation and difference between levels of the lumbar spine were demonstrated. A potential use for longitudinal study in post-operative follow up or sport medicine needs to be evaluated.

  12. Real T1 relaxation time measurement and diurnal variation analysis of intervertebral discs in a healthy population of 50 volunteers

    Energy Technology Data Exchange (ETDEWEB)

    Galley, J., E-mail: galleyjulien@gmail.com [Department of Radiology, HFR Fribourg, Hôpital Cantonal (Switzerland); Maestretti, G. [Department of Orthopedic Surgery, HFR Fribourg, Hôpital Cantonal (Switzerland); Koch, G.; Hoogewoud, H-M. [Department of Radiology, HFR Fribourg, Hôpital Cantonal (Switzerland)

    2017-02-15

    Purpose: To measure the real T1 relaxation time of the lumbar intervertebral discs in a young and healthy population, using different inversion recovery times, and assess diurnal variation. Material and methods: Intervertebral discs from D12 to S1 of 50 healthy volunteers from 18 to 25 years old were evaluated twice the same day, in the morning and in the late afternoon. Dedicated MRI sequences with different inversion recovery times (from 100 to 2500 ms) were used to calculate the real T1 relaxation time. Three regions of interest (ROIs) were defined in each disc, the middle representing the nucleus pulposus (NP) and the outer parts the annulus fibrosus (AF) anterior and posterior. Diurnal variation and differences between each disc level were analyzed. Results: T1 mean values in the NP were 1142 ± 12 ms in the morning and 1085 ± 13 ms in the afternoon, showing a highly significant decrease of 57 ms (p < 0.001). A highly significant difference between the levels of the spine was found. The mean T1 of the anterior part of the AF was 577 ± 9 ms in the morning and 554 ± 8 ms in the afternoon. For the posterior part, the mean values were 633 ± 8 ms in the morning and 581 ± 7 ms in the evening. It shows a highly significant decrease of 23 ms for the anterior part and 51 ms for the posterior part (all p < 0.001). Conclusion: T1 mapping is a promising method of intervertebral disc evaluation. Significant diurnal variation and difference between levels of the lumbar spine were demonstrated. A potential use for longitudinal study in post-operative follow up or sport medicine needs to be evaluated.

  13. Analysis of the diffusion tensor imaging parameters of a normal cervical spinal cord in a healthy population.

    Science.gov (United States)

    Wei, Liang-Feng; Wang, Shou-Sen; Zheng, Zhao-Cong; Tian, Jun; Xue, Liang

    2017-05-01

    Diffusion tensor imaging (DTI) shows great advantage in the diagnosis of brain diseases, including cervical spinal cord (CSC) disease. This study aims to obtain the normal values of the DTI parameters for a healthy population and to establish a baseline for CSC disease diagnosis using DTI. A total of 36 healthy adults were subjected to magnetic resonance imaging (MRI) for the entire CSC using the Siemens 3.0 T MR System. Sagittal DTI acquisition was carried out with a single-shot spin-echo echo-planar imaging (EPI) sequence along 12 non-collinear directions. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were determined at different cervical levels using a region of interest (ROI) method, following which they were correlated with parameters, like age and sex. Further, diffusion tensor tracking (DTT) was carried out to reconstruct the white matter fiber bundles of the CSC. The full and complete fiber bundle structure of a normal CSC was confirmed in both the T2-weighted and DTI images. The FA and ADC values were significantly negatively correlated with each other and showed strongly negative and positive correlations with age, respectively, but not with sex. Additionally, there was no significant difference between the FA and the ADC values at different cervical levels. The DTI technique can act as an important supplement to the conventional MRI technique for CSC observation. Moreover, the FA and ADC values can be used as sensitive parameters in the DTI study on the CSC by taking the effects of age into consideration.

  14. Are published standards for haematological indices in pregnancy applicable across populations: an evaluation in healthy pregnant Jamaican women

    Directory of Open Access Journals (Sweden)

    Mullings Anthony M

    2008-02-01

    Full Text Available Abstract Background The haematological profile of the pregnant woman has an impact on the outcome of the pregnancy. Published guidelines indicate acceptable levels for haematological indices in pregnancy but they are population specific. Indicators of haemoglobin concentration are the most commonly utilized of the indices. These published international norms are used across populations, however, there is no evidence confirming their applicability to a population such as the Jamaican pregnant woman. This study was therefore undertaken with the intent of documenting the haematological profile of pregnant primigravid Jamaican women and comparing these to the established norms to determine whether the norms apply or whether there was a need to establish local norms. Methods This was a longitudinal study done on a cohort of 157 healthy primigravid women ages 15 to 25 and without anaemia, and who were recruited from the antenatal clinic of the University Hospital of the West Indies, Kingston, Jamaica. The haemoglobin concentration, packed cell volume, mean cell volume, mean cell haemoglobin, mean cell haemoglobin concentration, white blood cell count, red blood cell count and platelet count were measured on samples of blood obtained from each consenting participant during each of the three trimesters. The results were analysed using SPSS for windows (Version 11 and the data expressed as means ± S.D. Means were compared using the student's paired t-test. Comparison was then made with the international norms as recommended by the United States Center for Disease Control (1989. Ethical approval for this study was obtained from the University Hospital of the West Indies/University of the West Indies Ethics Committee. Results The results showed changes by trimester in all measured variables. For most of the indices the changes achieved levels of significance across trimesters. These changes were however in keeping with the expected physiological response

  15. Adapting the Healthy Eating Index 2010 for the Canadian Population: Evidence from the Canadian National Nutrition Survey.

    Science.gov (United States)

    Jessri, Mahsa; Ng, Alena Praneet; L'Abbé, Mary R

    2017-08-21

    The Healthy Eating Index (HEI) is a diet quality index shown to be associated with reduced chronic disease risk. Older versions of the HEI have been adapted for Canadian populations; however, no Canadian modification of the Healthy Eating Index-2010 (HEI-2010) has been made. The aims of this study were: (a) to develop a Canadian adaptation of the HEI-2010 (i.e., Healthy Eating Index-Canada 2010 (HEI-C 2010)) by adapting the recommendations of the HEI-2010 to Canada's Food Guide (CFG) 2007; (b) to evaluate the validity and reliability of the HEI-C 2010; and (c) to examine relationships between HEI-C 2010 scores with diet quality and the likelihood of being obese. Data from 12,805 participants (≥18 years) were obtained from the Canadian Community Health Survey Cycle 2.2. Weighted multivariate logistic regression was used to test the association between compliance to the HEI-C 2010 recommendations and the likelihood of being obese, adjusting for errors in self-reported dietary data. The total mean error-corrected HEI-C 2010 score was 50.85 ± 0.35 out of 100. Principal component analysis confirmed multidimensionality of the HEI-C 2010, while Cronbach's α = 0.78 demonstrated internal reliability. Participants in the fourth quartile of the HEI-C 2010 with the healthiest diets were less likely to consume refined grains and empty calories and more likely to consume beneficial nutrients and foods ( p -trend < 0.0001). Lower adherence to the index recommendations was inversely associated with the likelihood of being obese; this association strengthened after correction for measurement error (Odds Ratio: 1.41; 95% Confidence Interval: 1.17-1.71). Closer adherence to Canada's Food Guide 2007 assessed through the HEI-C 2010 was associated with improved diet quality and reductions in the likelihood of obesity when energy intake and measurement errors were taken into account. Consideration of energy requirements and energy density in future updates of Canada's Food Guide are

  16. Adapting the Healthy Eating Index 2010 for the Canadian Population: Evidence from the Canadian Community Health Survey

    Science.gov (United States)

    Ng, Alena Praneet; L’Abbé, Mary R.

    2017-01-01

    The Healthy Eating Index (HEI) is a diet quality index shown to be associated with reduced chronic disease risk. Older versions of the HEI have been adapted for Canadian populations; however, no Canadian modification of the Healthy Eating Index-2010 (HEI-2010) has been made. The aims of this study were: (a) to develop a Canadian adaptation of the HEI-2010 (i.e., Healthy Eating Index-Canada 2010 (HEI-C 2010)) by adapting the recommendations of the HEI-2010 to Canada’s Food Guide (CFG) 2007; (b) to evaluate the validity and reliability of the HEI-C 2010; and (c) to examine relationships between HEI-C 2010 scores with diet quality and the likelihood of being obese. Data from 12,805 participants (≥18 years) were obtained from the Canadian Community Health Survey Cycle 2.2. Weighted multivariate logistic regression was used to test the association between compliance to the HEI-C 2010 recommendations and the likelihood of being obese, adjusting for errors in self-reported dietary data. The total mean error-corrected HEI-C 2010 score was 50.85 ± 0.35 out of 100. Principal component analysis confirmed multidimensionality of the HEI-C 2010, while Cronbach’s α = 0.78 demonstrated internal reliability. Participants in the fourth quartile of the HEI-C 2010 with the healthiest diets were less likely to consume refined grains and empty calories and more likely to consume beneficial nutrients and foods (p-trend < 0.0001). Lower adherence to the index recommendations was inversely associated with the likelihood of being obese; this association strengthened after correction for measurement error (Odds Ratio: 1.41; 95% Confidence Interval: 1.17–1.71). Closer adherence to Canada’s Food Guide 2007 assessed through the HEI-C 2010 was associated with improved diet quality and reductions in the likelihood of obesity when energy intake and measurement errors were taken into account. Consideration of energy requirements and energy density in future updates of Canada’s Food

  17. Adapting the Healthy Eating Index 2010 for the Canadian Population: Evidence from the Canadian Community Health Survey

    Directory of Open Access Journals (Sweden)

    Mahsa Jessri

    2017-08-01

    Full Text Available The Healthy Eating Index (HEI is a diet quality index shown to be associated with reduced chronic disease risk. Older versions of the HEI have been adapted for Canadian populations; however, no Canadian modification of the Healthy Eating Index-2010 (HEI-2010 has been made. The aims of this study were: (a to develop a Canadian adaptation of the HEI-2010 (i.e., Healthy Eating Index-Canada 2010 (HEI-C 2010 by adapting the recommendations of the HEI-2010 to Canada’s Food Guide (CFG 2007; (b to evaluate the validity and reliability of the HEI-C 2010; and (c to examine relationships between HEI-C 2010 scores with diet quality and the likelihood of being obese. Data from 12,805 participants (≥18 years were obtained from the Canadian Community Health Survey Cycle 2.2. Weighted multivariate logistic regression was used to test the association between compliance to the HEI-C 2010 recommendations and the likelihood of being obese, adjusting for errors in self-reported dietary data. The total mean error-corrected HEI-C 2010 score was 50.85 ± 0.35 out of 100. Principal component analysis confirmed multidimensionality of the HEI-C 2010, while Cronbach’s α = 0.78 demonstrated internal reliability. Participants in the fourth quartile of the HEI-C 2010 with the healthiest diets were less likely to consume refined grains and empty calories and more likely to consume beneficial nutrients and foods (p-trend < 0.0001. Lower adherence to the index recommendations was inversely associated with the likelihood of being obese; this association strengthened after correction for measurement error (Odds Ratio: 1.41; 95% Confidence Interval: 1.17–1.71. Closer adherence to Canada’s Food Guide 2007 assessed through the HEI-C 2010 was associated with improved diet quality and reductions in the likelihood of obesity when energy intake and measurement errors were taken into account. Consideration of energy requirements and energy density in future updates of Canada

  18. THE AVERAGE ANNUAL EFFECTIVE DOSES FOR THE POPULATION IN THE SETTLEMENTS OF THE RUSSIAN FEDERATION ATTRIBUTED TO ZONES OF RADIOACTIVE CONTAMINATION DUE TO THE CHERNOBYL ACCIDENT (FOR ZONATION PURPOSES, 2014

    Directory of Open Access Journals (Sweden)

    G. Ja. Bruk

    2015-01-01

    Full Text Available The Chernobyl accident in 1986 is one of the most large-scale radiation accidents in the world. It led to radioactive contamination of large areas in the European part of the Russian Federation and at the neighboring countries. Now, there are more than 4000 settlements with the total population of 1.5 million in the radioactively contaminated areas of the Russian Federation. The Bryansk region is the most intensely contaminated region. For example, the Krasnogorskiy district still has settlements with the level of soil contamination by cesium-137 exceeding 40 Cu/km2. The regions of Tula, Kaluga and Orel are also significantly affected. In addition to these four regions, there are 10 more regions with the radioactively contaminated settlements. After the Chernobyl accident, the affected areas were divided into zones of radioactive contamination. The attribution of the settlements to a particular zone is determined by the level of soil contamination with 137Cs and by a value of the average annual effective dose that could be formed in the absence of: 1 active measures for radiation protection, and 2 self-limitation in consumption of the local food products. The main regulatory document on this issue is the Federal law № 1244-1 (dated May, 15,1991 «On the social protection of the citizens who have been exposed to radiation as a result of the accident at the Chernobyl nuclear power plant». The law extends to the territories, where, since 1991: – The average annual effective dose for the population exceeds 1 mSv (the value of effective dose that could be formed in the absence of active radiation protection measures and self-limitation in consumption of the local food products; – Soil surface contamination with cesium-137 exceeds 1 Cu/km2. The paper presents results of calculations of the average effective doses in 2014. The purpose was to use the dose values (SGED90 in zonation of contaminated territories. Therefore, the

  19. Therapeutic dosage assessment based on population pharmacokinetics of a novel single-dose transdermal donepezil patch in healthy volunteers.

    Science.gov (United States)

    Choi, Hee Youn; Kim, Yo Han; Hong, Donghyun; Kim, Seong Su; Bae, Kyun-Seop; Lim, Hyeong-Seok

    2015-08-01

    We performed population pharmacokinetic (PK) analysis of a novel transdermal donepezil patch in healthy subjects who participated in a phase I trial. We also studied the optimal dosage regimen with repeated patch application for achieving a therapeutic range using a PK simulation model. This study used data from a randomized, single-dose escalation phase I clinical trial conducted in Korea. The population PK analysis was performed using NONMEM software, version 7.3. From the final PK model, we simulated repeat patch application results assuming various transdermal absorption rates. Based on the clinical trial data, novel donepezil patches with doses of 43.75 mg/12.5 cm(2), 87.5 mg/25 cm(2), and 175 mg/50 cm(2) were placed on each subject. A linear one-compartment, first-order elimination with sequential zero- and first-order absorption model best described the donepezil plasma concentrations after patch application. Simulated results on the basis of the PK model showed that repeat application of the patches of 87.5 mg/25 cm(2) and 175 mg/50 cm(2) every 72 h would cover the therapeutic range of donepezil and reach steady-state faster with fewer fluctuations in concentration compared to typical oral administrations. A linear one-compartment with sequential zero- and first-order absorption model was effective for describing the PKs of donepezil after application of patch. Based on this analysis, 87.5 mg/25 cm(2) or 175 mg/50 cm(2) patch application every 72 h is expected to achieve the desired plasma concentration of donepezil.

  20. Whole-body magnetic resonance imaging of healthy volunteers. Pilot study results from the population-based SHIP study

    Energy Technology Data Exchange (ETDEWEB)

    Hegenscheid, K.; Kuehn, J.P.; Hosten, N.; Puls, R. [Inst. fuer Diagnostische Radiologie und Neuroradiologie, Universitaetsklinikum der Ernst-Moritz-Arndt-Univ. Greifswald (Germany); Voelzke, H. [Inst. fuer Community Medicine, Universitaetsklinikum der Ernst-Moritz-Arndt-Univ. Greifswald (Germany); Biffar, R. [Zentrum fuer Zahn-, Mund- und Kieferheilkunde, Universitaetsklinikum der Ernst-Moritz-Arndt-Univ. Greifswald (Germany)

    2009-08-15

    Purpose: Approximately 4000 volunteers will undergo whole-body magnetic resonance imaging (WB-MRI) within the next 3 years in the population-based Study of Health in Pomerania (SHIP). Here we present a pilot study conducted (a) to determine the feasibility of adding a WB-MRI protocol to a large-scale population-based study, (b) to evaluate the reliability of standardized MRI interpretation, and (c) to establish an approach for handling pathological findings. Materials and Methods: The institutional review board approved the study, and oral and written informed consent was obtained from each participant. Two hundred healthy volunteers (99 women, 101 men; mean age 48.3 years) underwent a standardized WB-MRI protocol. The protocol was supplemented by contrast-enhanced cardiac MR1 and magnetic resonance (MR) angiography in 61 men (60.4%) and cardiac MRI and MR mammography in 44 women (44.4%). MR scans were evaluated independently by two readers. Abnormalities were discussed by an advisory board and classified according to the need for further clinical work-up. Results: One hundred ninety-four (97.0%) WB-MRI examinations were successfully completed in a mean scan time per subject of 90 minutes. There were 431 pathological findings in 176 (88%) of the participants. Of those 45 (10.4%) required further clinical work-up and 386 (89.6%) characterized as benign lesions did not. The interobserver agreement for the detection of pathological findings was excellent (K = 0.799) (orig.)

  1. Whole-body magnetic resonance imaging of healthy volunteers. Pilot study results from the population-based SHIP study

    International Nuclear Information System (INIS)

    Hegenscheid, K.; Kuehn, J.P.; Hosten, N.; Puls, R.; Voelzke, H.; Biffar, R.

    2009-01-01

    Purpose: Approximately 4000 volunteers will undergo whole-body magnetic resonance imaging (WB-MRI) within the next 3 years in the population-based Study of Health in Pomerania (SHIP). Here we present a pilot study conducted (a) to determine the feasibility of adding a WB-MRI protocol to a large-scale population-based study, (b) to evaluate the reliability of standardized MRI interpretation, and (c) to establish an approach for handling pathological findings. Materials and Methods: The institutional review board approved the study, and oral and written informed consent was obtained from each participant. Two hundred healthy volunteers (99 women, 101 men; mean age 48.3 years) underwent a standardized WB-MRI protocol. The protocol was supplemented by contrast-enhanced cardiac MR1 and magnetic resonance (MR) angiography in 61 men (60.4%) and cardiac MRI and MR mammography in 44 women (44.4%). MR scans were evaluated independently by two readers. Abnormalities were discussed by an advisory board and classified according to the need for further clinical work-up. Results: One hundred ninety-four (97.0%) WB-MRI examinations were successfully completed in a mean scan time per subject of 90 minutes. There were 431 pathological findings in 176 (88%) of the participants. Of those 45 (10.4%) required further clinical work-up and 386 (89.6%) characterized as benign lesions did not. The interobserver agreement for the detection of pathological findings was excellent (K = 0.799) (orig.)

  2. Astrophysical Russian Dolls

    OpenAIRE

    Loeb, Abraham; Imara, Nia

    2017-01-01

    Are there examples of "astrophysical Russian dolls," and what could we learn from their similarities? In this article, we list a few such examples, including disks, filaments, and clusters. We suggest that forging connections across disciplinary borders enhances our perception of beauty, while simultaneously leading to a more comprehensive understanding of the Universe.

  3. RUSSIAN LANGUAGE COURSES

    CERN Document Server

    2000-01-01

    Russian Language Courses will be given at CERN from mid-September. For details, please call the teacher, Mrs Mascha Mikhailova, tel. + 41 22 782 62 29. At CERN, please send an e-mail to esthel.laperriere@cern.ch.

  4. Resting mechanomyographic amplitude for the erector spinae and trapezius muscles following resistance exercise in a healthy population

    International Nuclear Information System (INIS)

    Wages, Nathan P; Beck, Travis W; Ye, Xin; Hofford, Craig W

    2013-01-01

    Musculoskeletal disorders are some of the most commonly occurring chronic conditions affecting the US population, with the most self-reported and diagnosed disorder being low back pain. Low back pain is often due to suboptimal back muscle function, at least in part, as a result of muscle inactivity and disuse. Resistance exercise has been shown to be successful in the treatment of low back pain. The purpose of the present investigation was to examine resting mechanomyographic (MMG) amplitude for the erector spinae and trapezius muscles prior to and following resistance exercise. Twenty healthy, college-aged men were measured for resting MMG amplitude levels prior to, and following a resistance training workout. The workout consisted of three sets of ten repetitions on the conventional deadlift, bent-over row, and lat pulldown exercises, with 1 min of rest between all sets and exercises. The results showed that there were approximate 10% and 15% decreases in normalized MMG amplitude after exercise for the erector spinae and trapezius muscles, respectively. These findings demonstrate a relaxation effect in the back muscles after exercise that could potentially be helpful in alleviating low back pain. (paper)

  5. Fecal Microbiota in Healthy Subjects Following Omnivore, Vegetarian and Vegan Diets: Culturable Populations and rRNA DGGE Profiling.

    Science.gov (United States)

    Ferrocino, Ilario; Di Cagno, Raffaella; De Angelis, Maria; Turroni, Silvia; Vannini, Lucia; Bancalari, Elena; Rantsiou, Kalliopi; Cardinali, Gianluigi; Neviani, Erasmo; Cocolin, Luca

    2015-01-01

    In this study, the fecal microbiota of 153 healthy volunteers, recruited from four different locations in Italy, has been studied by coupling viable counts, on different microbiological media, with ribosomal RNA Denaturing Gradient Gel Electrophoresis (rRNA-DGGE). The volunteers followed three different diets, namely omnivore, ovo-lacto-vegetarian and vegan. The results obtained from culture-dependent and -independent methods have underlined a high level of similarity of the viable fecal microbiota for the three investigated diets. The rRNA DGGE profiles were very complex and comprised a total number of bands that varied from 67 to 64 for the V3 and V9 regions of the 16S rRNA gene, respectively. Only a few bands were specific in/of all three diets, and the presence of common taxa associated with the dietary habits was found. As far as the viable counts are concerned, the high similarity of the fecal microbiota was once again confirmed, with only a few of the investigated groups showing significant differences. Interestingly, the samples grouped differently, according to the recruitment site, thus highlighting a higher impact of the food consumed by the volunteers in the specific geographical locations than that of the type of diet. Lastly, it should be mentioned that the fecal microbiota DGGE profiles obtained from the DNA were clearly separated from those produced using RNA, thus underlining a difference between the total and viable populations in the fecal samples.

  6. The AGE-RAGE axis in an Arab population: The United Arab Emirates Healthy Futures (UAEHFS pilot study

    Directory of Open Access Journals (Sweden)

    Claire K. Inman

    2017-12-01

    Full Text Available Aims: The transformation of the United Arab Emirates (UAE from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS. Methods: 517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML-AGE, soluble (sRAGE and endogenous secretory (esRAGE were measured along with weight, height, waist and hip circumference (WC/HC, blood pressure, HbA1c, Vitamin D levels and routine chemistries. The relationship between the AGE-RAGE axis and obesity and diabetes mellitus was tested using proportional odds models and linear regression. Results: After covariate adjustment, AGE levels were significantly associated with diabetes status. Levels of sRAGE and esRAGE were associated with BMI and levels of sRAGE were associated with WC/HC. Conclusions: The AGE-RAGE axis is associated with diabetes status and obesity in this Arab population. Prospective serial analysis of this axis may identify predictive biomarkers of obesity and cardiometabolic dysfunction in the UAEHFS. Keywords: Advanced glycation endproducts (AGEs, Receptor for AGE (RAGE, Cohort study, Diabetes mellitus, Obesity

  7. The AGE-RAGE axis in an Arab population: The United Arab Emirates Healthy Futures (UAEHFS) pilot study.

    Science.gov (United States)

    Inman, Claire K; Aljunaibi, Abdullah; Koh, Hyunwook; Abdulle, Abdishakur; Ali, Raghib; Alnaeemi, Abdullah; Al Zaabi, Eiman; Oumeziane, Naima; Al Bastaki, Marina; Al-Houqani, Mohammed; Al-Maskari, Fatma; Al Dhaheri, Ayesha; Shah, Syed M; Abdel Wareth, Laila; Al Mahmeed, Wael; Alsafar, Habiba; Al Anouti, Fatme; Al Hosani, Ayesha; Haji, Muna; Galani, Divya; O'Connor, Matthew J; Ahn, Jiyoung; Kirchhoff, Tomas; Sherman, Scott; Hayes, Richard B; Li, Huilin; Ramasamy, Ravichandran; Schmidt, Ann Marie

    2017-12-01

    The transformation of the United Arab Emirates (UAE) from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts) axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS). 517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML)-AGE, soluble (s)RAGE and endogenous secretory (es)RAGE were measured along with weight, height, waist and hip circumference (WC/HC), blood pressure, HbA1c, Vitamin D levels and routine chemistries. The relationship between the AGE-RAGE axis and obesity and diabetes mellitus was tested using proportional odds models and linear regression. After covariate adjustment, AGE levels were significantly associated with diabetes status. Levels of sRAGE and esRAGE were associated with BMI and levels of sRAGE were associated with WC/HC. The AGE-RAGE axis is associated with diabetes status and obesity in this Arab population. Prospective serial analysis of this axis may identify predictive biomarkers of obesity and cardiometabolic dysfunction in the UAEHFS.

  8. Fecal Microbiota in Healthy Subjects Following Omnivore, Vegetarian and Vegan Diets: Culturable Populations and rRNA DGGE Profiling

    Science.gov (United States)

    Ferrocino, Ilario; Di Cagno, Raffaella; De Angelis, Maria; Turroni, Silvia; Vannini, Lucia; Bancalari, Elena; Rantsiou, Kalliopi; Cardinali, Gianluigi; Neviani, Erasmo; Cocolin, Luca

    2015-01-01

    In this study, the fecal microbiota of 153 healthy volunteers, recruited from four different locations in Italy, has been studied by coupling viable counts, on different microbiological media, with ribosomal RNA Denaturing Gradient Gel Electrophoresis (rRNA-DGGE). The volunteers followed three different diets, namely omnivore, ovo-lacto-vegetarian and vegan. The results obtained from culture-dependent and -independent methods have underlined a high level of similarity of the viable fecal microbiota for the three investigated diets. The rRNA DGGE profiles were very complex and comprised a total number of bands that varied from 67 to 64 for the V3 and V9 regions of the 16S rRNA gene, respectively. Only a few bands were specific in/of all three diets, and the presence of common taxa associated with the dietary habits was found. As far as the viable counts are concerned, the high similarity of the fecal microbiota was once again confirmed, with only a few of the investigated groups showing significant differences. Interestingly, the samples grouped differently, according to the recruitment site, thus highlighting a higher impact of the food consumed by the volunteers in the specific geographical locations than that of the type of diet. Lastly, it should be mentioned that the fecal microbiota DGGE profiles obtained from the DNA were clearly separated from those produced using RNA, thus underlining a difference between the total and viable populations in the fecal samples. PMID:26035837

  9. Fecal Microbiota in Healthy Subjects Following Omnivore, Vegetarian and Vegan Diets: Culturable Populations and rRNA DGGE Profiling.

    Directory of Open Access Journals (Sweden)

    Ilario Ferrocino

    Full Text Available In this study, the fecal microbiota of 153 healthy volunteers, recruited from four different locations in Italy, has been studied by coupling viable counts, on different microbiological media, with ribosomal RNA Denaturing Gradient Gel Electrophoresis (rRNA-DGGE. The volunteers followed three different diets, namely omnivore, ovo-lacto-vegetarian and vegan. The results obtained from culture-dependent and -independent methods have underlined a high level of similarity of the viable fecal microbiota for the three investigated diets. The rRNA DGGE profiles were very complex and comprised a total number of bands that varied from 67 to 64 for the V3 and V9 regions of the 16S rRNA gene, respectively. Only a few bands were specific in/of all three diets, and the presence of common taxa associated with the dietary habits was found. As far as the viable counts are concerned, the high similarity of the fecal microbiota was once again confirmed, with only a few of the investigated groups showing significant differences. Interestingly, the samples grouped differently, according to the recruitment site, thus highlighting a higher impact of the food consumed by the volunteers in the specific geographical locations than that of the type of diet. Lastly, it should be mentioned that the fecal microbiota DGGE profiles obtained from the DNA were clearly separated from those produced using RNA, thus underlining a difference between the total and viable populations in the fecal samples.

  10. Effect of BDNF Val66Met polymorphism on digital working memory and spatial localization in a healthy Chinese Han population.

    Science.gov (United States)

    Gong, Pingyuan; Zheng, Anyun; Chen, Dongmei; Ge, Wanhua; Lv, Changchao; Zhang, Kejin; Gao, Xiaocai; Zhang, Fuchang

    2009-07-01

    Cognitive abilities are complex human traits influenced by genetic factors. Brain-derived neurotrophic factor (BDNF), a unique polypeptide growth factor, has an influence on the differentiation and survival of neurons in the nervous system. A single-nucleotide polymorphism (rs6265) in the human gene, resulting in a valine to methionine substitution in the pro-BDNF protein, was thought to associate with psychiatric disorders and might play roles in the individual difference of cognitive abilities. However, the specific roles of the gene in cognition remain unclear. To investigate the relationships between the substitution and cognitive abilities, a healthy population-based study and the PCR-SSCP method were performed. The results showed the substitution was associated with digital working memory (p = 0.02) and spatial localization (p = 0.03), but not with inhibition, shifting, updating, visuo-spatial working memory, long-term memory, and others (p > 0.05) among the compared genotype groups analyzed by general linear model. On the other hand, the participants with BDNF (GG) had higher average performance in digital working memory and spatial localization than the ones with BDNF (AA). The findings of the present work implied that the variation in BDNF might play positive roles in human digital working memory and spatial localization.

  11. Coronary heart disease risk factors in adult premenopausal white women with polycystic ovary syndrome compared with a healthy female population.

    Science.gov (United States)

    Glueck, Charles J; Morrison, John A; Goldenberg, Naila; Wang, Ping

    2009-05-01

    Our specific aim was to determine whether coronary heart disease (CHD) risk factors in polycystic ovary syndrome (PCOS) patients were independent of their higher body mass index (BMI) and centripetal obesity. In adult, premenopausal, white women, CHD risk factors were compared between 488 patients with well-defined PCOS and 351 healthy free-living population controls from the Princeton Follow-up Study (PFS). After excluding women with irregular menses (putative PCOS phenotypes), comparisons were also made between the 261 PFS women with a history of regular menses and the 488 women with PCOS. Fasting lipids, insulin, glucose, homeostasis model assessment of insulin resistance (HOMA-IR), HOMA insulin secretion, blood pressure, BMI, and waist circumference were measured. Compared with both the full cohort of 351 PFS women and the subgroup of 261 PFS women with regular menses, women with PCOS had higher BMI, waist circumference, total and low-density lipoprotein cholesterol, triglyceride, systolic blood pressure, diastolic blood pressure, insulin, glucose, and HOMA-IR (all Ps PCOS, compared with the 351 and 261 PFS women, had lower high-density lipoprotein cholesterol (P PCOS women with normal BMI (PCOS cannot be exclusively attributed to their preponderant centripetal obesity. Identification of women with clinical features of PCOS should alert the clinician to potentially increased risk for CHD and prompt CHD risk factor testing.

  12. Big russian oil round

    International Nuclear Information System (INIS)

    Slovak, K.; Beer, G.

    2006-01-01

    The departure of Mikhail Khodorkovsky has brought an end to the idyllic times of supplies of Russian oil to the MOL-Slovnaft group. The group used to purchase oil directly from Yukos. But now brokers have again entered the Central European oil business. And their aim is to take control over all of the oil business. The Russians demonstrated the changed situation to Slovakia last autumn: you will either accept the new model, or there will be problems with oil deliveries. Consumers got the message. The main brokers of Russian oil in Central Europe are the Swiss companies Glencore and Fisotra. Little information is available regarding these commodity brokers. But the information available is sufficient to indicate that these are not small companies. Glencore undertakes 3% of all international oil trades. With an annual turnover of 72 billions USD, it was the biggest Swiss company by turnover in 2004. Fisotra also has an extensive product portfolio. It offers financial and commercial services and does not hide its good relations with Russian oil companies. Between 1994 and 1998, it managed their financial operations with major western companies such as BP, Cargill, Elf, Exxon, Shell, Total, and Mutsubishi and also with Glencore. Fisotra states that some of its clients achieved an annual turnover of 1.5 billions USD. At present, the Swiss brokers receive a fee of 1 to 1.5 USD per barrel. The Russian political elite must be aware of these brokerage services as the oil transport through the transit system is closely monitored by the state owned company Transneft. (authors)

  13. Reliability of exophthalmos measurement and the exophthalmometry value distribution in a healthy Dutch population and in Graves' patients. An exploratory study

    NARCIS (Netherlands)

    Mourits, M. P.; Lombardo, S. H. C.; van der Sluijs, F. A.; Fenton, S.

    2004-01-01

    AIM: The purpose of this study was to test the reliability of an exophthalmometer commonly used in the Netherlands; to determine the exophthalmometry value distribution with this instrument and to assess the upper exophthalmometry limits of normal in a healthy, adult, Caucasian, Dutch population.

  14. Prevalence and type of monoclonal gammopathy of undetermined significance in an apparently healthy Nigerian population: a cross sectional study.

    Science.gov (United States)

    Onwah, A Lawretta; Adeyemo, Titilope A; Adediran, Adewumi; Ajibola, Sarah O; Akanmu, Alani S

    2012-06-28

    The prevalence of monoclonal gammopathy of undetermined significance (MGUS), a premalignant plasma-cell disorder has not been determined in our geographic area Nigeria. A cross sectional survey was carried on apparently healthy Nigerians selected by multistage sampling technique from the cosmopolitan city of Lagos, Nigeria. Subjects enrolled into the study had 2-step screening for the presence, type and concentration of monoclonal band. Agarose-gel electrophoresis was performed on all serum samples, and any serum sample with a discrete band of monoclonal protein or thought to have a localized band was subjected to Immunofixation. Subjects were also evaluated for Bence jones proteinuria, haematological and biochemical parameters. Four hundred and ten subjects with a mean age of 45.68 ± 10.3 years, a median of 45.00 years and a range of 20 to 80 years were enrolled into the study. MGUS was identified in only one (0.24 percent) of the 410 study subject. This subject was demonstrated to have a double monoclonal gammopathy; IgGλ at 16.9 g/L and IgAκ at 8.5 g/L. None of them including the sole subject with MGUS had a monoclonal urinary light chain. Among residents of Lagos, Nigeria, MGUS was found in only 0.24% percent of apparently normal persons with a median age of 45 years. This suggests that MGUS which represents the earliest stage of monoclonal plasma/lymphoid cell proliferation is not a common finding in the relatively young population of Nigeria. Future epidemiologic studies dealing with plasma cell disorders in older people are required to carefully examine the relationship between environmental factors and prevalence of MGUS and its ultimate progression to MM.

  15. Prevalence and type of monoclonal gammopathy of undetermined significance in an apparently healthy Nigerian population: a cross sectional study

    Directory of Open Access Journals (Sweden)

    Onwah A

    2012-06-01

    Full Text Available Abstract Background The prevalence of monoclonal gammopathy of undetermined significance (MGUS, a premalignant plasma-cell disorder has not been determined in our geographic area Nigeria. Methods A cross sectional survey was carried on apparently healthy Nigerians selected by multistage sampling technique from the cosmopolitan city of Lagos, Nigeria. Subjects enrolled into the study had 2-step screening for the presence, type and concentration of monoclonal band. Agarose-gel electrophoresis was performed on all serum samples, and any serum sample with a discrete band of monoclonal protein or thought to have a localized band was subjected to Immunofixation. Subjects were also evaluated for Bence jones proteinuria, haematological and biochemical parameters. Results Four hundred and ten subjects with a mean age of 45.68 ± 10.3 years, a median of 45.00 years and a range of 20 to 80 years were enrolled into the study. MGUS was identified in only one (0.24 percent of the 410 study subject. This subject was demonstrated to have a double monoclonal gammopathy; IgGλ at 16.9 g/L and IgAκ at 8.5 g/L. None of them including the sole subject with MGUS had a monoclonal urinary light chain. Conclusion Among residents of Lagos, Nigeria, MGUS was found in only 0.24% percent of apparently normal persons with a median age of 45 years. This suggests that MGUS which represents the earliest stage of monoclonal plasma/lymphoid cell proliferation is not a common finding in the relatively young population of Nigeria. Future epidemiologic studies dealing with plasma cell disorders in older people are required to carefully examine the relationship between environmental factors and prevalence of MGUS and its ultimate progression to MM.

  16. Long term reduction of Caesium and Strontium transfer factors from soil in foodstuff and dynamics of internal doses for a russian population after the Chernobyl accident

    International Nuclear Information System (INIS)

    Shutov, V.N.; Bruk, J.Ja.; Travnikova, I.G.; Balonov, M.I.

    2002-01-01

    The model of the formation of the internal doses for the population living on the territory contaminated after the Chernobyl accident is described. Model parameters were obtained on the base of natural measurements results implemented in the different terms after the accident. The data on the caesium radionuclides content in the bodies of the inhabitants measurements were priority for the internal exposure dose estimation. In the case of the absence of such information, the results of the radionuclides content in the food products analysis or the data on the soil types prevailing in the areas of settlements, were used for the calculations. The data were obtained during 1986-2001 as a result of monitoring of contaminated areas in Russia that considerably differ in their soil and climate conditions, the levels of 1 37C s and 9 0S r surface activity on soil and types of countermeasures applied. A summary of effective half-lives (T 1/2 ) of 1 37C s and 9 0S r aggregated transfer factors (Tag) from soil into agricultural and natural products observed after the Chernobyl fallout is given. The short term decrease of 1 37C s Tag from soil into milk and beef during two months after fallout were observed - T 1/2 varied from 13 d to 36 d in depend on the part of dry and wet fallout. The studies between autumn 1986 and 1991 suggest a decrease in the 1 37C s Tag with T 1/2 /2 =1-2 years. From 5-6 years after deposition onwards T 1/2 /2 of 1 37 Cs and 9 0S r Tag's in the range of 8 to 21 years were observed. Effective half-lives of 1 37C s Tag's for foods from semi-natural ecosystems (mushrooms, berries, game, fish) are longer (up to tens years). On at least for some natural products the decrease seems to be only to radioactive decay. Comparison of the data on the dynamics of 1 37C s content in agricultural and natural food products indicates that the contribution of the latter in the internal dose of population grows with each year after fallout, and can reach in the remote

  17. Comparison of hepatitis E virus seroprevalence between HBsAg-positive population and healthy controls in Shandong province, China.

    Science.gov (United States)

    Zhang, Li; Jiang, Zechun; Lv, Jingjing; Liu, Jiaye; Yan, Bingyu; Feng, Yi; Li, Li; Zhang, Guomin; Wang, Fuzhen; Xu, Aiqiang

    2018-02-12

    Persons with chronic hepatitis B (CHB) infection were reported to suffer severe disease after hepatitis E virus (HEV) superinfection, but the studies regarding HEV seroprevalence in this population were limited. A recent study in Vietnam found higher HEV seroprevalence among CHB patients compared with healthy controls. A community-based case-control study was conducted in two counties of Shandong province, China, where hepatitis E incidence was at the highest (Rushan) and lowest (Zhangqiu) in the province based on data from routine public health surveillance. Four townships were selected randomly from each county and all residents in these townships were tested for hepatitis B surface antigen (HBsAg). Those tested positive for HBsAg (CHB group) and the 1:1 age and sex-matched HBsAg-negative residents (control group) were included. Anti-HEV IgM and IgG were tested and positive rates of IgG and IgM were compared between the CHB group and the control group. In total, 2048 CHB participants and 2054 controls were included in the study. In the CHB group, HEV IgG seroprevalence was 9.16% (95% CI: 7.47-11.09) in Zhangqiue and 38.06% (95% CI: 35.07-41.19) in Rushan (P < 0.001); the corresponding rates of IgM were 0.1% (95% CI: 0.002-0.54) and 1.57% (95% CI: 0.90-2.53), respectively (P < 0.001). HEV IgG seroprevalence was similar between CHB group and the control group in both counties (P = 0.21, P = 0.47, respectively) and the same results were found for the positive rate of IgM (P = 0.103, P = 0.262, respectively). Multivariable analysis showed the status of HBsAg was not independently associated with the status of anti-HEV IgG in either Zhangqiu or Rushan [P = 0.187, OR = 1.23(95% CI: 0.90, 1.68); P = 0.609, OR = 1.05 (95% CI: 0.87, 1.26)]. The seroprevalence of HEV varies greatly in different geographic areas, but the seroprevalence is similar between populations with and without CHB. CHB patients residing in high HEV endemic areas

  18. Russian nuclear survey

    International Nuclear Information System (INIS)

    2002-07-01

    This document gives a broad overview of the organization of nuclear activities in the Russian federation: Minatom activities, nuclear park and availability (reactors, performances, export activity), perspectives of development (improvement of safety, age of reactors, new realizations); fuel cycle (uranium production, conversion and enrichment, fuel fabrication, spent fuel reprocessing); wastes management (storage and disposal sites); R and D activities (organizations) and nuclear safety authority. (J.S.)

  19. Profile of individuals who are metabolically healthy obese using different definition criteria. A population-based analysis in the Spanish population.

    Science.gov (United States)

    Martínez-Larrad, María Teresa; Corbatón Anchuelo, Arturo; Del Prado, Náyade; Ibarra Rueda, José María; Gabriel, Rafael; Serrano-Ríos, Manuel

    2014-01-01

    Obesity is associated with numerous metabolic complications such as diabetes mellitus type 2, dyslipidemia, hypertension, cardiovascular diseases and several forms of cancer. Our goal was to compare different criteria to define the metabolically healthy obese (MHO) with metabolically unhealthy obese (MUHO) subjects. We applied Wildman (W), Wildman modified (WM) with insulin resistance (IR) with cut-off point ≥ 3.8 and levels of C- Reactive Protein (CRP) ≥ 3 mg/l; and Consensus Societies (CS) criteria. In these subjects cardiovascular-risk (CV-risk) was estimated by Framingham score and SCORE for MHO and MUHO. A cross-sectional study was conducted in Spanish Caucasian adults. A total of 3,844 subjects completed the study, 45% males, aged 35-74 years. Anthropometric/biochemical variables were measured. Obesity was defined as BMI: ≥ 30 Kg/m(2). The overall prevalence of obesity in our population was 27.5%, (23.7%/males and 30.2%/females). MHO prevalence according to W, WM, and CS definition criteria were: 9.65%, 16.29%, 39.94% respectively in obese participants. MHO has lower waist circumference (WC) measurements than MUHO. The estimated CV-risks by Framingham and SCORE Project charts were lower in MHO than MUHO subjects. WC showed high specificity and sensitivity in detecting high estimated CV risk by Framingham. However, WHR showed high specificity and sensitivity in detecting CV risk according to SCORE Project. MHO subjects as defined by any of the three criteria had higher adiponectin levels after adjustment by sex, age, WC, HOMA IR and Framingham or SCORE risks. This relationship was not found for CRP circulating levels neither leptin levels. MHO prevalence is highly dependent on the definition criteria used to define those individuals. Results showed that MHO subjects had less WC, and a lower estimated CV-risk than MUHO subjects. Additionally, the high adiponectin circulating levels in MHO may suggest a protective role against developing an unhealthy

  20. Profile of individuals who are metabolically healthy obese using different definition criteria. A population-based analysis in the Spanish population.

    Directory of Open Access Journals (Sweden)

    María Teresa Martínez-Larrad

    Full Text Available BACKGROUND: Obesity is associated with numerous metabolic complications such as diabetes mellitus type 2, dyslipidemia, hypertension, cardiovascular diseases and several forms of cancer. Our goal was to compare different criteria to define the metabolically healthy obese (MHO with metabolically unhealthy obese (MUHO subjects. We applied Wildman (W, Wildman modified (WM with insulin resistance (IR with cut-off point ≥ 3.8 and levels of C- Reactive Protein (CRP ≥ 3 mg/l; and Consensus Societies (CS criteria. In these subjects cardiovascular-risk (CV-risk was estimated by Framingham score and SCORE for MHO and MUHO. METHODS: A cross-sectional study was conducted in Spanish Caucasian adults. A total of 3,844 subjects completed the study, 45% males, aged 35-74 years. Anthropometric/biochemical variables were measured. Obesity was defined as BMI: ≥ 30 Kg/m(2. RESULTS: The overall prevalence of obesity in our population was 27.5%, (23.7%/males and 30.2%/females. MHO prevalence according to W, WM, and CS definition criteria were: 9.65%, 16.29%, 39.94% respectively in obese participants. MHO has lower waist circumference (WC measurements than MUHO. The estimated CV-risks by Framingham and SCORE Project charts were lower in MHO than MUHO subjects. WC showed high specificity and sensitivity in detecting high estimated CV risk by Framingham. However, WHR showed high specificity and sensitivity in detecting CV risk according to SCORE Project. MHO subjects as defined by any of the three criteria had higher adiponectin levels after adjustment by sex, age, WC, HOMA IR and Framingham or SCORE risks. This relationship was not found for CRP circulating levels neither leptin levels. CONCLUSIONS: MHO prevalence is highly dependent on the definition criteria used to define those individuals. Results showed that MHO subjects had less WC, and a lower estimated CV-risk than MUHO subjects. Additionally, the high adiponectin circulating levels in MHO may suggest a

  1. A community-based, environmental chronic disease prevention intervention to improve healthy eating psychosocial factors and behaviors in indigenous populations in the Canadian Arctic.

    Science.gov (United States)

    Mead, Erin L; Gittelsohn, Joel; Roache, Cindy; Corriveau, André; Sharma, Sangita

    2013-10-01

    Diet-related chronic diseases are highly prevalent among indigenous populations in the Canadian Arctic. A community-based, multi-institutional nutritional and lifestyle intervention-Healthy Foods North-was implemented to improve food-related psychosocial factors and behaviors among Inuit and Inuvialuit in four intervention communities (with two comparison communities) in Nunavut and the Northwest Territories, Canada, in 2008. The 12-month program was developed from theory (social cognitive theory and social ecological models), formative research, and a community participatory process. It included an environmental component to increase healthy food availability in local stores and activities consisting of community-wide and point-of-purchase interactive educational taste tests and cooking demonstrations, media (e.g., radio ads, posters, shelf labels), and events held in multiple venues, including recreation centers and schools. The intervention was evaluated using pre- and postassessments with 246 adults from intervention and 133 from comparison communities (311 women, 68 men; mean age 42.4 years; 78.3% retention rate). Outcomes included psychosocial constructs (healthy eating knowledge, self-efficacy, and behavioral intentions), frequency of healthy and unhealthy food acquisition, healthiness of commonly used food preparation methods, and body mass index (kg/m(2)). After adjustment for demographic, socioeconomic status, and body mass index variables, respondents living in intervention communities showed significant improvements in food-related self-efficacy (β = 0.15, p = .003) and intentions (β = 0.16, p = .001) compared with comparison communities. More improvements from the intervention were seen in overweight, obese, and high socioeconomic status respondents. A community-based, multilevel intervention is an effective strategy to improve psychosocial factors for healthy nutritional behavior change to reduce chronic disease in indigenous Arctic populations.

  2. Russian electrometallurgy: Achievements, problems, prospects

    Science.gov (United States)

    Utochkin, Yu. I.; Semin, A. E.

    2011-12-01

    The changes in the Russian metallurgy, in particular, electric furnace steelmaking, having occurred in the recent years are analyzed. The main increase in the steelmaking output is due to putting into operation of new electric furnaces in new miniworks and enterprises equipped earlier with open-hearth furnaces. Reaching the rated capacity of a furnace in Russia substantially lags behind foreign enterprises. Only 30-35% of the Russian market of corrosion-resistant steel are provided by Russian metal.

  3. RUSSIAN REVOLUTION WAS PREPARED ON CAPRI...” MICHAIL PERVUKHIN ABOUT A RUSSIAN COLONY ON CAPRI (BASED ON THE A.M. GORKY ARCHIVE

    Directory of Open Access Journals (Sweden)

    Marina A. Arias-Vikhil

    2017-03-01

    Full Text Available In his essay “The Russians on Capri” (1924, a Russian journalist Mikhail Pervukhin describes the discovery of Capri by Russian artists and writers before the events of 1905 and the development of the Russian colony on the island afterwards. Pervukhin relates the origin and the history of the Russian colony on Capri to the period from 1906 through 1913, when the island became a residence of Russian political immigrants. He sees Gorky’s arrival on Capri as a major catalyzer in the development of the colony due to the defining and formative nature of the political and literary activity of the latter. The Russian revolution of 1905 had radically changed the structure of the Russian population on Capri: since that time it mostly consisted of political refugees. Pervukhin’s evidence is one of the most important documents on Gorky’s reception in Italy. Pervukhin left documentary and artistic evidence of Gorky’s residence on the island written with a special focus on Gorky’s role in the Russian Revolution of 1917 and its critical reconsideration. The author emphasized the political component in the life of the colony. He criticized activities of the Capri school for workers founded by Gorky and Lunacharsky. According to Pervukhin, Russian revolutionaries were indifferent to the beauty of the island and to the “eternal” values swept away by the storm of the October Revolution.

  4. The Healthy Toddlers Trial Protocol: An Intervention to Reduce Risk Factors for Childhood Obesity in Economically and Educationally Disadvantaged Populations

    Directory of Open Access Journals (Sweden)

    Auld Garry

    2011-07-01

    Full Text Available Abstract Background The number of overweight children in America has doubled to an estimated 10 million in the past 20 years. Establishing healthy dietary behaviors must begin early in childhood and include parents. The Healthy Toddlers intervention focuses on promoting healthy eating habits in 1- to 3-year-old children utilizing the Social Cognitive Theory and a learner-centered approach using Adult Learning principles. This Healthy Toddlers Trial aims to determine the efficacy of a community-based randomized controlled trial of an in-home intervention with economically and educationally disadvantaged mothers of toddlers. The intervention focuses on: (a promoting healthy eating behaviors in toddlers while dietary habits are forming; and (b providing initial evidence for the potential of Healthy Toddlers as a feasible intervention within existing community-based programs. Methods/Design This describes the study protocol for a randomized control trial, a multi-state project in Colorado, Michigan, and Wisconsin with economically and educationally disadvantaged mother-toddler dyads; toddlers are between 12 and 36 months. The Healthy Toddlers intervention consists of eight in-home lessons and four reinforcement telephone contacts, focusing on fruit, vegetable, and sweetened beverage consumption and parental behaviors, taught by paraprofessional instructors. Healthy Toddlers uses a randomized, experimental, short-term longitudinal design with intervention and control groups. In-home data collection (anthropometric measurements, feeding observations, questionnaires, 3-day dietary records occurs at baseline, immediately following the intervention, and 6 months after the intervention. Main toddler outcomes include: a increased fruit and vegetable consumption and decreased sweetened beverage consumption; and b improved toddler-eating skills (self-feeding and self-serving. Main parent outcomes include: a improved psychosocial attributes (knowledge

  5. The Russian Orthodox and Islamic Languages in the Russian Federation

    NARCIS (Netherlands)

    Bustanov, A.K.; Kemper, M.

    2013-01-01

    What happens to the Russian language if it is used by Muslims? Bustanov and Kemper (2012) analyzed the use of Islamic terminology in a variety of texts by contemporary Muslim authors from several regions of the Russian Federation. This led them to the hypothesis that one can speak of a new

  6. "Signs of honor" among Russian inmates in Israel's prisons.

    Science.gov (United States)

    Shoham, Efrat

    2010-12-01

    The unique nature of Israeli society as an immigrant society has also affected the prison population in Israel. This article focuses on a social and cultural phenomenon that particularly characterizes the prisoners of Russian origin, the phenomenon of tattoos. Using postmodernist theories, the article examines the function of the tattoo among Russian prisoners and the role it plays in constructing the criminal self-identity of these inmates in Israeli prisons. The tattoos observed during 2005-2006 among the Russian prisoners in four major Israeli prisons reflect the values of the Russian criminal subculture from which they evolved and were imported. This subculture is characterized by a hierarchical class structure and manifestations of machismo, domination, defiance, rebellion, and open antagonism against the Establishment and its representatives.

  7. Approaches of Russian oil companies to optimal capital structure

    Science.gov (United States)

    Ishuk, T.; Ulyanova, O.; Savchitz, V.

    2015-11-01

    Oil companies play a vital role in Russian economy. Demand for hydrocarbon products will be increasing for the nearest decades simultaneously with the population growth and social needs. Change of raw-material orientation of Russian economy and the transition to the innovative way of the development do not exclude the development of oil industry in future. Moreover, society believes that this sector must bring the Russian economy on to the road of innovative development due to neo-industrialization. To achieve this, the government power as well as capital management of companies are required. To make their optimal capital structure, it is necessary to minimize the capital cost, decrease definite risks under existing limits, and maximize profitability. The capital structure analysis of Russian and foreign oil companies shows different approaches, reasons, as well as conditions and, consequently, equity capital and debt capital relationship and their cost, which demands the effective capital management strategy.

  8. RUSSIAN STOCK MARKET INSTITUTIONAL PARTICIPANTS: HABITUS AND PRACTICES

    Directory of Open Access Journals (Sweden)

    Boris Borisovich Podgorny

    2017-11-01

    Full Text Available The global investment experience shows that economic growth is impossible without the creation of an effective national stock market. Also, along with the solution of the funds inflow into the economy, developed stock market contributes the creation of a mass economy owners community. Economic characteristics – economy demand for credit resources (especially in sanction terms, the availability of the savings among the Russian population, rates reduction on bank deposits, – saying that “investment boom” should take place in Russia today, in which a significant part of the population must be taken mass participation in the stock market, including the way through collective investment. However, the current situation does not allow us to talk about the successful development this direction of the Russian stock market. In this article, prepared in the framework of the author’s special sociological theory «The Russian Stock Market as a Social Space» [27], presented the results of Russian stock market institutional investors study including: the statistical indicators characterizing institutional investors on the stock market were analyzed; the practices caused by the existing habitus of Russian stock market institutional investors were classified and studied. It was found that the habitus of most institutional investors participating in the Russian stock market is marked a speculative nature.

  9. Meta-analysis: Problems with Russian Publications.

    Science.gov (United States)

    Verbitskaya, E V

    2015-01-01

    pharmaceutical products for prevention of stroke recurrence. For the first product, we did not found even two single Russian language studies suitable for the analysis (incomparable populations, different designs, endpoints, doses etc.). For the second product, only four studies had comparable populations and standard internationally approved scales for effectiveness analysis. However, the combinations of scales, the length of treatment and follow up differed widely, so that we could combine the results of only 2 or 3 studies for each end point. Russian researchers have to follow internationally recognised standards in study design, selection of endpoint, timelines and therapy regimens, data analysis and presentation of results. Russian journals need to develop consolidate rules for authors of clinical trials and epidemiological research of result reporting close to international standards. In this case the international Network EQUATOR (Enhancing the QUAlity and Transparency Of health Research http://www.equator-network.org/) is one to be taken into account. In addition, Russian Journals have to improve their online information for better interaction with search engines and citation managers.

  10. Russian gas in 1993

    International Nuclear Information System (INIS)

    Wilson, D.C.

    1994-01-01

    Natural gas output in Russia fell by 3.5% in 1993. This followed decades of rapid growth in production reaching a peak in 1991 and a minor fall in 1993. Gas consumption also peaked in 1991 and fell by 5% over the two following years. The major cause of the decline in consumption is the fall in electricity demand which has accompanied the economic recession. Gas has accounted for about 60% of the reduction in fuel consumption by power stations. Gas consumption by industrial and municipal boilers has also dropped steeply although household and other municipal consumption has increased. The fall in demand does not wholely account for the fall in production, however. Apart from Yamburg, all operational gas fields have now reached the stage of declining production. Government officials are talking tentatively of 1997 as the turning point for the Russian economy and following this, the demand for gas will rise again. It is not certain, however, that the industry will be able to meet the increased demand which is anticipated. Most of the increased production will have to come from new fields in the Yamal Peninsular the development of which is proceeding much more slowly than planned. In the longer term, possibly in the early years of the next century, the Shtokmanovsk gasfield in the Barents Sea may be developed. Other aspects of the Russian gas industry briefly covered are reserves, financing of exploratory drilling, investment, intra-CIS trade and exports and privatisation of the state owned company Garyprom. (UK)

  11. Do Russians Need Cliotherapia?

    Directory of Open Access Journals (Sweden)

    Boris N. Mironov

    2016-10-01

    Full Text Available The author gives detailed answers to the comments made by all eighteen round table participants in the course of the discussions that unfolded around his book “The Russian Empire: From Tradition to Modernity”. A fundamental debate on many of the issues raised in the book is conducted in the article. Among them: methodology and technique, in particular, the use of a variety of research strategies, the application of comparative historical approach, interdisciplinarity, macro- and micro-analysis, the search for patterns, the role of concepts, and the relationship between empirical and analytical aspects in the study. Much attention is paid to the controversial aspects of ethnoconfessional policies, mentalité and historical psychology, the unresolved issues of serfdom and colonization, cultural capital and educational policies, as well as self-government and civil society. The discussion concerning the specifics of Russian modernization and the issue of myth making occupies an important place in the article, as does historical optimism and cliotherapy.

  12. RUSSIAN INDUSTRY INVESTMENT SITUATION

    Directory of Open Access Journals (Sweden)

    O. V. Pochukaeva

    2011-01-01

    Full Text Available The actual deficiency of investment into Russian industry innovative development increases its technological drag from industries of countries with developed markets. Although the rate of investment into real sectors of Russian economics mid 2000 was higher compared to the previous period, annual investment amounts were much lower than in 1990. At present, highest investment amounts are directed to industry extractive branches and to the commerce. Amounts invested to various economy branches do not correspond to their contribution to the country’sGross Added Product; particularly underinvested are manufacturing industry branches. At present, foreign share in the country economy total investment makes 15–18%. Recently, most interesting for foreigners was investment to machine-building branches with overwhelming part (for example, 90% in 2007–2008 of foreign investment into the machine-building industry being directed to creation of new automobile plants. Today, first place in the list of foreign investors’ preferences in Russia is taken by the machine-tool construction sector.

  13. Russian JV workovers proliferating

    Energy Technology Data Exchange (ETDEWEB)

    1992-11-09

    Well remediation is gathering momentum in Russia as more companies apply western technology to idle wells. Western petroleum technology is being widely hailed as the best way to halt the decline in crude oil production in Russia and other members of the former Soviet Union. More than 20,000 Russian wells are estimated idle, many of which observers say could be returned to service with western know-how. Progress has been outlined on two significant projects in the Komi and Chechen autonomous republics of Russia: KomiQuest Ltd., a joint venture of an international group of companies and Komi republic agencies, has used a Russian rig and crew to work over four wells and started producing oil in one of four Vozey area oil fields in the Komi republic. A Chechen republic delegation led by President Dzhahar Jusyavitch Dudaev last month in Houston let a 2 year contract worth about $100 million to Enforce Energy Corp., San Antonio, covering workover, drilling, and other services in two oil fields north of the Chechen capital of Grozny.

  14. Unknown Russian giant

    International Nuclear Information System (INIS)

    Ross, Priscilla.

    1996-01-01

    The present position and future potential of the Russian oil company Tatneft are assessed. Tatneft, the eighteenth largest oil company in the world, has 85 oil fields and over 20,700 production wells. In 1995, it increased its production by 6% to 504,000bpd and its crude oil exports outside Russia were 213,000bpd. The company forms the basis of the oil industry in the semi-autonomous republic of Tatarstan. Tafneft became a joint stock company in May 1994 with the government of Tatarstan as the largest shareholder with a 46% stake. Although Tafneft produces far more crude than Conoco or YPF, its market capitalisation per barrel of production is only 5% of these companies. Its long-term future lies in successfully increasing production and enhancing financial performance. The former is being addressed through enhanced oil recovery methods and various joint ventures are being entered into with western partners in order to tap foreign expertise and to finance modern equipment. The achievement of the latter requires an improvement towards world prices of the price for Russian domestic crude and a reduction in the tax burden away from revenue towards a profits basis. (UK)

  15. High frequency of circulating ¿d T cells with dominance of the vd1 subset in a healthy population

    DEFF Research Database (Denmark)

    Hviid, L; Akanmori, B D; Loizon, S

    2000-01-01

    TCR gamma delta(+) cells constitute <5% of all circulating T cells in healthy, adult Caucasians, and V(delta)1(+) cells constitute a minority of these cells. In contrast to TCR alpha beta(+) cells, their repertoire is selected extrathymically by environmental antigens. Although increased frequenc...

  16. Variations of B cell subpopulations in peripheral blood of healthy Mexican population according to age: Relevance for diagnosis of primary immunodeficiencies.

    Science.gov (United States)

    Berrón-Ruíz, L; López-Herrera, G; Ávalos-Martínez, C E; Valenzuela-Ponce, C; Ramírez-SanJuan, E; Santoyo-Sánchez, G; Mújica Guzmán, F; Espinosa-Rosales, F J; Santos-Argumedo, L

    Peripheral blood B cells include lymphocytes at various stages of differentiation, each with a specific function in the immune response. All these stages show variations in percentage and absolute number throughout human life. The numbers and proportions of B subpopulation are influenced by factors such as gender, age, ethnicity, and lifestyle. This study establishes reference values according to age of peripheral blood B cell subtypes in healthy Mexican population. Peripheral blood from healthy new-borns and adults were analysed for total B cell subpopulations, using surface markers such as CD19, IgM, IgD, CD21, CD24, CD27, and CD38, to identify naïve, memory with and without isotype switch, double-negative, transitional, and plasmablast cells. We observed a significant variation in terms of frequency and absolute counts between all groups analysed. Values from each B cell subpopulation show variations according to age. In order to attempt to elucidate reference values for B cell subpopulation, the present study evaluated a population sample of healthy blood donors from this region. Values reported here can also be used as a tool for diagnosis of diseases in which B cell maturation is affected. Copyright © 2016 SEICAP. Published by Elsevier España, S.L.U. All rights reserved.

  17. Cognitive-behavioral phenotypes of Williams syndrome are associated with genetic variation in the GTF2I gene, in a healthy population.

    Science.gov (United States)

    Crespi, Bernard J; Hurd, Peter L

    2014-11-28

    Individuals with Williams syndrome, a neurogenetic condition caused by deletion of a set of genes at chromosomal location 7q11.23, exhibit a remarkable suite of traits including hypersociality with high, nonselective friendliness and low social anxiety, expressive language relatively well-developed but under-developed social-communication skills overall, and reduced visual-spatial abilities. Deletions and duplications of the Williams-syndrome region have also been associated with autism, and with schizophrenia, two disorders centrally involving social cognition. Several lines of evidence have linked the gene GTF2I (General Transcription Factor IIi) with the social phenotypes of Williams syndrome, but a role for this gene in sociality within healthy populations has yet to be investigated. We genotyped a large set of healthy individuals for two single-nucleotide polymorphisms in the GTF2I gene that have recently been significantly associated with autism, and thus apparently exhibit functional effects on autism-related social phenotypes. GTF2I genotypes for these SNPs showed highly significant association with low social anxiety combined with reduced social-communication abilities, which represents a metric of the Williams-syndrome cognitive profile as described from previous studies. These findings implicate the GTF2I gene in the neurogenetic basis of social communication and social anxiety, both in Williams syndrome and among individuals in healthy populations.

  18. [Gain for pain: a model of a healthy lifestyle intervention in a population of mentally disabled adults].

    Science.gov (United States)

    Bardugo, Esther; Moses, Lilach; Shemmer, Martha; Dubman, Innesa

    2010-10-01

    Mental retardation is an intellectual disability affecting adaptable, conceptual, social and practical skills, with onset prior to 18 years of age. Prevalence of obesity among women with mental retardation is 18-30% greater than that among women without mental retardation. In the Nachman Village, a governmental institution for adults with mental retardation, the main nutritional difficulties result from residents eating snacks in addition to their balanced meals. Psychological complexity and the ambivalent attitude of families, caregivers and residents prevented the achievement of balanced diets and healthy body weights. The women's house mother took upon herself to detect residents with nutritional problems and started an intervention program aiming at promoting a healthy lifestyle and maintenance of normal body weight. The program 'House Queen' was Launched on a voluntary basis. The staff encouraged the residents to engage in physical activity, restrict snack consumption and amounts of food at meals, eat vegetables and not waste pocket money on non-nutritional foods. Each month one or two residents who lost weight while maintaining a healthy lifestyle received a prize and the title "House Queen". The statistical analysis included 22 residents and was conducted retrospectively from data coLlected during a routine medical follow-up. A total of 59.1% of the residents were morbidly obese and 27.3% were obese at the beginning of the program. Seventeen months later, they weighed an average of 8 kg Less, and only 36.4% and 18.2% of them were morbidly obese and obese, respectively. These results suggest a correlation between the 'House Queen' program and Lowering body weight, which encourage the authors to broaden the program to other residents in the Village and combine supportive and restrictive attitudes towards a healthy lifestyle for mentally disabled people.

  19. Medication overuse, healthy lifestyle behaviour and stress in chronic headache: Results from a population-based representative survey.

    Science.gov (United States)

    Westergaard, Maria Lurenda; Glümer, Charlotte; Hansen, Ebba Holme; Jensen, Rigmor Højland

    2016-01-01

    This cross-sectional study investigated associations between chronic headache (CH) with and without medication overuse, healthy lifestyle behaviour, and stress. Questionnaires were sent to 129,150 adults. Those with headache ≥15 days per month for three months were classified as having CH then further described as having medication-overuse headache (MOH) or CH without medication overuse. Associations between headache and daily smoking, physical inactivity, obesity, excessive drinking, illicit drug use, and high stress were analysed by logistic regression. CH with and without medication overuse (prevalence 1.8% and 1.6%, respectively) had strong, graded associations with stress. Associations with daily smoking, physical inactivity, and obesity were significant only for MOH. Odds for MOH were highest among people who had all three factors compared to those who had none (OR 2.8 in women and 5.1 in men). High stress plus any of these three factors had synergistic effects in MOH but not clearly in those who had CH without overuse. Associations between CH subtypes and excessive drinking or illicit drug use were not statistically significant. Results suggest strong links between healthy lifestyle behaviour and stress in MOH. Stress reduction and promoting healthy behaviour are highly relevant in MOH management. © International Headache Society 2015.

  20. Russian-Saudian Political Interaction

    Directory of Open Access Journals (Sweden)

    G. G. Kosach

    2017-01-01

    Full Text Available The article analyzes the development of Russian-Saudi political interaction after the restoration (at that time of Soviet-Saudi relations of bilateral relations in September 1990. The article focuses on the role of the Russian Muslim community in shaping the Russian politics towards Riyadh in the 1990-2000s. The authors state there are both periods of “crises” and detente in the development of Russian-Saudi political interaction that were marked by events in Chechnya and former Yugoslavia in 1994-2000, “Arab Spring” 2011, the post-September 2015 era, the Russian anti-terrorist campaign in Syria. The alternation of these periods is the constant of Russian-Saudi political contacts, despite the similarity in the approaches of both sides to the ways and methods of solving crisis situations in the Middle East region, as well as the Saudi’s pro-Russian position regarding the change in the status of the Crimea and the situation in the east of Ukraine. The general attitude of both sides towards ISIS and Jabha al-Nusra as a source of terrorism, regional instability and the challenge of international security does not remove the two main contradictions that divide Moscow and Riyadh – attitude toward the official Syrian regime and the Iran’s regional policy. The study comes to the conclusion that Russia and Saudi Arabia are interested (albeit for various reasons in diversifying their foreign policy and foreign economic relations.

  1. Adaptation of Russian Christian Names into the Mari Language

    Directory of Open Access Journals (Sweden)

    Alexander L. Pustyakov

    2017-11-01

    Full Text Available This article analyses the phonetic and morphological adaptation of Christian personal names in the Mari language. The work examines personal names recorded in different regions among the Mari. The composition of the presented data is not exhaustive; it does, however, allow one to observe some general patterns of the adaptation process. The main part of the article is preceded by a brief overview of the Christianization of the Mari region and the contacts between the Mari and the Russian-speaking population; the features of the local dialects of the Russian language are briefly stated. The Mari language incorporated a significant number of Russian names. The source of loans included, besides the standard church name forms, also the numerous varieties found in the Russian dialects. As part of the study, phonetic, structural changes of Christian names in the Mari language are revealed and the reasons for the majority of these transformations are identified. The author also pays attention to the intermediary role of the neighbouring Turkic languages in the penetration of Russian names into the Mari language. Changes in borrowed names were induced by internal Mari linguistic rules, as well as dialectal features of the local Russian dialects. The identification of systematic phonetic and structural transformations helps to determine the origin of obscure anthroponyms.

  2. Prevalence of enteroviruses in healthy populations and excretion of pathogens in patients with hand, foot, and mouth disease in a highly endemic area of southwest China.

    Directory of Open Access Journals (Sweden)

    Qiang Wu

    Full Text Available Etiological carriers and the excretion of the pathogens causing hand, foot, and mouth disease (HFMD in healthy persons, patients, and asymptomatic persons infected with HFMD as ongoing infection sources may play an important role in perpetuating and spreading epidemics of HFMD. The aims of this study were to determine the carrier status of EV-A71 and CV-A16 in healthy populations, as well as the duration of EV-A71 and CV-A16 shedding in the stools of HFMD patients in an epidemic area of southwest China. A cross-sectional study and a follow-up study were conducted in three HFMD endemic counties of Yunnan Province. Six hundred sixty-seven healthy subjects were recruited to participate in the cross-sectional study, and two stool specimens were collected from each subject. Among the healthy subjects, 90 (13.5% tested positive for viral isolation, but neither EV-A71 nor CV-A16 was detected in healthy individuals. Of the 150 patients with probable HFMD, 55.3% (83/150 tested positive for viral isolation with presented serotypes such as EV-A71 (51.81%, 43/83, CV-A16 (32.53%, 27/83, other EVs (13.25%, 11/83, and mixed EV-A71 and CV-A16 (2.41%, 2/83. The longest duration of EV-A71 and CV-A16 shedding in stool specimens from patients with HFMD was >46 days after onset. The positive rate of EV-A71 in the stool specimens of confirmed patients dropped to 50% by the end of the third week, and the same occurred with CV-A16 by the end of approximately the seventh week after onset. Although carriers of major causative agents of HFMD in healthy populations are fewer in number, the prolonged shedding of pathogens in patients with HFMD may serve as an important factor in perpetuating and spreading HFMD epidemics.

  3. IS RUSSIAN DECOMMODIFYING IN CATALONIA?

    Directory of Open Access Journals (Sweden)

    Микел Кабал-Гуарро

    2017-12-01

    Full Text Available The data collected in an ethnographic study conducted between 2014 and 2016 in tourist areas in Catalonia, Spain shows that the mastery of Russian has become a profitable commodity in Spanish tourism industry. The purpose of this paper is to show where and how Russian is used in the service industry and trace the commodification of the language over time. Against the background of fluctuating numbers of Russian-speaking visitors, this analysis will contribute to a better understanding of processes of language commodification and decommodification and the relationship between wider political and economic con-texts and valorisation of particular languages and speakers.

  4. ARE COMMUNITY –BASED INTERVENTION PROGRAMS EFFECTIVE IN THE YOUTH POPULATION? RESULTS FROM ISFAHAN HEALTHY HEART PROGRAM

    Directory of Open Access Journals (Sweden)

    Hamidreza Roohafza

    2010-11-01

    Full Text Available Abstract    BACKGROUND: Although the relationship between unhealthy lifestyle and development of non-communicable diseases in the youth has been understood but intervention studies to improve lifestyle behaviors in this age group are low. Consequently, this study was performed to highlight important intervention activity of a NCD prevention and health promotion program for young people and to present its main results in Iran.    METHODS: The Youth Intervention Project (YIP as a part of Isfahan Healthy Heart Program (IHHP was carried out on all the youth aged 19-25 years in Isfahan and Najafabad counties as intervention areas and Arak as control area. The target groups could be reached in Red Crescent Society, universities, and garrisons. Multifactorial interventions included healthy nutrition, physical activity, coping with stress, and tobacco cessation by more emphasis on hookah smoking. Also, enforcing no-smoking regulations in teahouses and coffee shops was considered.    RESULTS: After performing multifactorial interventions, the change of fast food consumption frequency was statistically significant in comparison between intervention and control areas (P for trend<0.05. Percentage of individuals with high stress level were more significant in intervention area compared with control area (P for trend<0.05. Smoking was increased among men and women in both areas whereas the increase was higher in control area (P for trend<0.05. Although daily physical activity frequency was increased in intervention areas but it wasn’t significant compared with control area. Also, decreased trend of carbonated drink consumption were not significant in intervention area compared with control area.     CONCLUSION: The lifestyle modification program in the youth was successfully implemented and was shown to have improved some of the youth’s lifestyle behaviors related to healthy lifestyle.      Keywords: Intervention,The youth, Non

  5. Systematic review on vitamin D level in apparently healthy Indian population and analysis of its associated factors

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    Sandhiya Selvarajan

    2017-01-01

    Full Text Available Background: Vitamin D which is involved in the maintenance of bone mineral homeostasis has been found to portray various pleiotropic effects. Although it has been widely accepted that serum 25-hydroxy Vitamin D level above 30 ng/ml is considered optimal for the biological actions of Vitamin D, there is a need to explore the levels of Vitamin D reported among Indians from various regions of the country. Hence, this systematic review aims to appraise the status of Vitamin D levels reported from apparently healthy Indians across various parts of India. Methodology: A comprehensive literature search was carried out to identify the range of Vitamin D levels among apparently healthy individuals from various parts of India, with the search term “Vitamin D and India” in the search portals of PubMed, Google Scholar, Indmed, and ScienceDirect. A total of 2998 articles were retrieved by the above search strategy, of which only forty studies fulfilled the criteria to be included in the systematic review. Studies done in various states were compiled under the respective zones based on the classification of Indian zones as specified in Zonal maps of India. Results: The level of Vitamin D from all the forty included studies ranged from 3.15 ± 1.4 to 52.9 ± 33.7 ng/ml. The effect size of Vitamin D level was higher in the South Zone compared to other zones. Conclusion: The present study shows that Vitamin D deficiency is prevalent among apparently healthy Indians living in different regions of India, irrespective of their exposure to sunlight.

  6. Survey of HFE Gene C282Y Mutation in Turkish Beta-Thalassemia Patients and Healthy Population: A Preliminary Study

    OpenAIRE

    Selma Ünal; Günay Balta; Fatma Gümrük

    2014-01-01

    Objective: This study was planned in order to determine the effect of C282Y mutation in development of secondary hemochromatosis in beta-thalassemia patients and to determine the prevalence and allele frequency of this mutation in a healthy control group. Materials and Methods: Eighty-seven children and young adults (46 males and 41 females; mean age: 15.6?6.1 years, range: 3-30 years) with beta-thalassemia major (BTM) and 13 beta-thalassemia intermedia (BTI) patients (6 males and 7 females; ...

  7. Russian Orthography and Learning to Read

    Science.gov (United States)

    Kerek, Eugenia; Niemi, Pekka

    2009-01-01

    The unique structure of Russian orthography may influence the organization and acquisition of reading skills in Russian. The present review examines phonemic-graphemic correspondences in Russian orthography and discusses its grain-size units and possible difficulties for beginning readers and writers. Russian orthography is governed by a…

  8. RUSSIAN PERIODICALS AT THE TURN OF THE 19TH -20TH CENTURIESON RUSSIAN MIGRANTS’ SOCIOCULTURAL ADAPTATION IN CENTRAL ASIA

    Directory of Open Access Journals (Sweden)

    Р А Арсланов

    2017-12-01

    Full Text Available In the Russian historiography, the views of the publicists of the early 20th century of the Russian colonists’ life in Central Asia aren’t duly highlighted. The novelty and aim of the research consist in revealing the general and particular in the Russian periodicals’ percep-tion of the colonization of Turkestan, in determining their ideological bent. The authors have discovered that all the reviewed periodicals were adherents of Central Asia colonization. They supported the imperial policy of the government with minor reserva-tions. Most publicists noted that the settling of colonists depended on the actions of the central government, which insuffi ciently took into account the local conditions. However, publicists differed in the choice of the main direction and in the assessments of the value of colonists’ adaptation activity; they proposed various ways of developing the intercultural dialogue.The authors come to the conclusions that liberal periodicals paid special attention to the economic activities of Russian immigrants, assessing the degree of their adaptation by the level of well-being achieved. The Narodnik periodicals considered migrants as a part of the peasant world of Russia. They were concerned, above all, about the colonists’ commu-nity, which they considered an effective means of adaptation, preserving the culture and moral qualities of the Russians. Probably, they considered it a pledge of building fair relations with the local population. Conservative and offi cial publicists viewed Russian immigrants primarily as support of the Russian government in Central Asia. That is why they paid special attention to the preservation of assimilation qualities of the Russians, the loss of which could become, in their view, an obstacle to the strengthening of the empire positions in the region.

  9. VWF mutations and new sequence variations identified in healthy controls are more frequent in the African-American population.

    Science.gov (United States)

    Bellissimo, Daniel B; Christopherson, Pamela A; Flood, Veronica H; Gill, Joan Cox; Friedman, Kenneth D; Haberichter, Sandra L; Shapiro, Amy D; Abshire, Thomas C; Leissinger, Cindy; Hoots, W Keith; Lusher, Jeanne M; Ragni, Margaret V; Montgomery, Robert R

    2012-03-01

    Diagnosis and classification of VWD is aided by molecular analysis of the VWF gene. Because VWF polymorphisms have not been fully characterized, we performed VWF laboratory testing and gene sequencing of 184 healthy controls with a negative bleeding history. The controls included 66 (35.9%) African Americans (AAs). We identified 21 new sequence variations, 13 (62%) of which occurred exclusively in AAs and 2 (G967D, T2666M) that were found in 10%-15% of the AA samples, suggesting they are polymorphisms. We identified 14 sequence variations reported previously as VWF mutations, the majority of which were type 1 mutations. These controls had VWF Ag levels within the normal range, suggesting that these sequence variations might not always reduce plasma VWF levels. Eleven mutations were found in AAs, and the frequency of M740I, H817Q, and R2185Q was 15%-18%. Ten AA controls had the 2N mutation H817Q; 1 was homozygous. The average factor VIII level in this group was 99 IU/dL, suggesting that this variation may confer little or no clinical symptoms. This study emphasizes the importance of sequencing healthy controls to understand ethnic-specific sequence variations so that asymptomatic sequence variations are not misidentified as mutations in other ethnic or racial groups.

  10. Trace element status and fatty acids metabolism during healthy ageing: an example of a population from the Tunisian eastern coast.

    Science.gov (United States)

    Sfar, Sonia; El Heni, Jihen; Laporte, François; Braham, Hamadi; Jawed, Abdelhafidh; Amor, Salah; Sfar, Mohamed Tahar; Kerkeni, Abdelhamid

    2012-03-01

    Micronutrients as well as essential fatty acids are indispensable for the correct functioning of the organism. The risk of disturbance in the associated nutrition and metabolism is expected to increase during ageing. In addition, it seems that trace elements are involved in the fatty acids metabolism. The aim of the present study was then to assess age-related changes in trace elements status and in plasma essential fatty acids composition with an emphasis on the desaturase activity estimation. Two hundred healthy Tunisian subjects (30-85 years old) were recruited and separated into two subgroups: elderly (65-85 years old) and middle-aged (30-60 years old). The findings revealed that plasma zinc and calcium concentrations significantly decreased according to age. The prevalence of zinc deficiency was therefore shown to increase in old age (over 60% of elderly subjects were deficient or at risk of deficiency). No age-related changes were obtained for copper or magnesium status. The Δ6 desaturase, involved in the EFAs conversion, was shown to decrease according to age and to be associated with the plasma zinc level. Since elderly subjects were at risk of nutritional imbalance, it would be interesting to set optimal dietary proportion. This will help to prevent age-associated alterations and diseases for a better and healthy ageing. Copyright © 2011 Elsevier Inc. All rights reserved.

  11. Validity of the Italian telephone version of the mini-mental state examination in the elderly healthy population.

    Science.gov (United States)

    Vanacore, Nicola; De Carolis, Antonella; Sepe-Monti, Micaela; Bomboi, Giuseppe; Stazi, Antonia; Bianchetti, Angelo; Giubilei, Franco

    2006-09-01

    The biggest challenge regarding cognitive prospective evaluations in the elderly is the identification of subjects that go on to develop cognitive impairment. In this study, we compared the Italian telephone version of the MMSE (Itel-MMSE) with both the MMSE and a battery of neuropsychological tests in a group of 107 healthy elderly subjects. The aim of the study was to identify a subset of subjects who, despite having an overall score within the normal range, performed poorly in the cognitive neuropsychological evaluation. The Itel-MMSE score showed a good internal consistency as well as a significant correlation with the MMSE score, age and education. A score of < or = 21 on the Itel-MMSE was the score which reflected the highest degree of sensitivity in the neuropsychological tests. There was a statistically significant difference between subjects with an Itel-MMSE score of < or = 21 and those with a score of 22 in age, education, Attentional Matrices and Copying Drawings. Despite some potential limitations, our results strongly suggest that the Itel-MMSE may be used as a screening test to identify healthy elderly subjects whose cognitive performance is poor.

  12. Quantifiers in Russian Sign Language

    NARCIS (Netherlands)

    Kimmelman, V.; Paperno, D.; Keenan, E.L.

    2017-01-01

    After presenting some basic genetic, historical and typological information about Russian Sign Language, this chapter outlines the quantification patterns it expresses. It illustrates various semantic types of quantifiers, such as generalized existential, generalized universal, proportional,

  13. Russian Federation country report

    Energy Technology Data Exchange (ETDEWEB)

    Labyntseva, Marina [Non governmental educational institution, ' ATOMPROF' , Aerodromnaya st., 4, 197348 St Petersburg (Russian Federation)

    2008-07-01

    Nuclear in the Russian Federation: 31 reactors at 10 nuclear power plants, 454 nuclear material storage facilities, 16475 sources of ionizing radiation, 1508 storage facilities for radioactive material and radioactive waste. Nuclear power: 10 nuclear power plants with total installed capacity of 23.242 GWe, Total nuclear electricity generation 160 bln kWh in 2007, Share of nuclear electricity in the overall electricity generation is 16%. Future of nuclear power: Nuclear power development program for the period from 2007 to 2020: Lifetime extension of existing units, Completion of construction of nuclear power units at existing sites (Rostov-2, Kalinin-4, Beloyarsk-4). Construction of new nuclear power plants near existing NPP (Novovoronezh NPP-2, Leningrad NPP-2, Kursk NPP-2,Kola NPP-2) and Construction of new nuclear power plants: (Nizhny Novgorod NPP, Tver NPP, Central NPP, South Urals NPP, Seversk NPP, Primorskaya NPP, 2 floating nuclear power plants at Severodvinsk and Pevek). Radioactive waste management: The Law on radioactive waste management will be introduced to State Duma in June 2008. The radioactive waste management strategy includes construction and reconstruction of: Storage facilities for some 120 thousand cubic meters, RW treatment complexes at nuclear fuel cycle enterprises, Storage facilities and RW treatment complexes at nuclear power plants, Storage facilities for RW coming from non-nuclear facilities for 140 thousand cubic meters, Decommissioning of 140 facilities, Decontamination of territories, buildings and constructions with the total area of 1658 thousand square meters. Development of competences: In 2006 about 313 thousand employees were working at nuclear industry (Top level managers - 0,6%, Intermediate level managers - 6,0%, Specialists - 31,6%, Workers - 62%). The demand of Rosatom State Corporation will be 7000 - 8000 persons annually of more then 140 professions, among them: 2800 persons with higher professional education, 2000

  14. Language categories in Russian morphology

    OpenAIRE

    زهرایی زهرایی

    2009-01-01

    When studying Russian morphology, one can distinguish two categories. These categories are “grammatical” and “lexico-grammatical”. Grammatical categories can be specified through a series of grammatical features of words. Considering different criteria, Russian grammarians and linguists divide grammatical categories of their language into different types. In determining lexico-grammatical types, in addition to a series of grammatical features, they also consider a series of lexico-semantic fe...

  15. Russian Revolution: triumph or tragedy?

    Directory of Open Access Journals (Sweden)

    Drozdov Sergey Valentinovich

    2017-04-01

    Full Text Available The present paper focuses on the most important events that happened in Petrograd from February to October 1917 and radically changed the whole character of the country. The paper also deals with their participants’ actions which turned out to be critical for Russian history. The research is based on credible sources and literature. The author tries to understand how the mighty Russian Empire collapsed within several days and why the left extremists took over as a result.

  16. "CLASS APPROACH" AND "PROLETARIAN CHARACTER" OF RUSSIAN REVOLUTION OF 1917

    Directory of Open Access Journals (Sweden)

    Эдуард Эдуардович Шульц

    2014-12-01

    Full Text Available Study of the problem of “class character” of 1917’ revolution and competency of the term “proletarian revolution”. The author considers questions of participation of various social groups in the Russian revolution, draws analogies of social composition of previous revolutions, considers the principle of “proletarian revolution”, as an ideology element for positioning of Bolsheviks and power capture. It is necessary to consider that an age, gender and national factor played much bigger role un Russian revolution than class factor. Revolution in Russia in many respects leaned on young generations which made more than a third of the population of the Russian Empire by 1917. In fight against tsarism separate calculation was based on the non-russian population and national suburbs of the empire. The special role in the Russian revolution was played by the peasantry. Revolution happened in the capital (in two capitals in Russia, the peasantry remained indifferent to revolution while Bolsheviks didn't begin to take away from them the food violently. This period:(summer - fall of 1919 became the time of peak of the Civil war. However return of landowners and their claim for property of the land forced peasants to turn bayonets for revolution and the earth and, eventually, to provide to Bolsheviks a victory in the Civil war.

  17. Evolution of gut Bifidobacterium population in healthy Japanese infants over the first three years of life: a quantitative assessment.

    Science.gov (United States)

    Nagpal, Ravinder; Kurakawa, Takashi; Tsuji, Hirokazu; Takahashi, Takuya; Kawashima, Kazunari; Nagata, Satoru; Nomoto, Koji; Yamashiro, Yuichiro

    2017-08-30

    Bifidobacteria are important members of human gut microbiota; however, quantitative data on their early-life dynamics is limited. Here, using a sensitive reverse transcription-qPCR approach, we demonstrate the carriage of eight signature infant-associated Bifidobacterium species (B. longum, B. breve, B. bifidum, B. catenulatum group, B. infantis, B. adolescentis, B. angulatum and B. dentium) in 76 healthy full-term vaginally-born infants from first day to three years of life. About 21% babies carry bifidobacteria at first day of life (6.2 ± 1.9 log 10  cells/g feces); and this carriage increases to 64% (8.0 ± 2.2), 79% (8.5 ± 2.1), 97% (9.3 ± 1.8), 99% (9.6 ± 1.6), and 100% (9.7 ± 0.9) at age 7 days, 1, 3 and 6 months, and 3 years, respectively. B. longum, B. breve, B. catenulatum group and B. bifidum are among the earliest and abundant bifidobacterial clades. Interestingly, infants starting formula-feed as early as first week of life have higher bifidobacterial carriage compared to exclusively breast-fed counterparts. Bifidobacteria demonstrate an antagonistic correlation with enterobacteria and enterococci. Further analyses also reveal a relatively lower/ delayed bifidobacterial carriage in cesarean-born babies. The study presents a quantitative perspective of the early-life gut Bifidobacterium colonization and shows how factors such as birth and feeding modes could influence this acquisition even in healthy infants.

  18. Healthy Places for Healthy People

    Science.gov (United States)

    Describes the Healthy Places for Healthy People technical assistance program that helps communities create walkable, healthy, economically vibrant places by engaging with local health care facility partners

  19. A multicenter study on PIVKA reference interval of healthy population and establishment of PIVKA cutoff value for hepatocellular carcinoma diagnosis in China.

    Science.gov (United States)

    Qin, X; Tang, G; Gao, R; Guo, Z; Liu, Z; Yu, S; Chen, M; Tao, Z; Li, S; Liu, M; Wang, L; Hou, L; Xia, L; Cheng, X; Han, J; Qiu, L

    2017-08-01

    The aim of this study was to investigate the reference interval of protein-induced vitamin K absence or antagonist-II (PIVKA-II) in China population and to evaluate its medical decision level for hepatocellular carcinoma (HCC) diagnosis. To determine the reference range for Chinese individuals, a total of 855 healthy subjects in five typical regions of China were enrolled in this study to obtain a 95% reference interval. In a case-control study which recruited the subjects diagnosed with HCC, metastatic liver cancer, bile duct cancer, hepatitis, cirrhosis, other benign liver diseases and the subjects administrated anticoagulant, receiver operating characteristic analysis was used to determine PIVKA-II cutoff value for a medical decision. The concentration of PIVKA-II had no relationship with age or gender and that region was a significant factor associated with the level of PIVKA-II. The 95% reference interval determined in this study for PIVKA-II in Chinese healthy individuals was 28 mAU/mL, and the cutoff value which to distinguish patients with HCC from disease control groups is 36.5 mAU/mL. In clinical applications, it is recommended that each laboratory chooses their own reference interval based on the regional population study or cutoff value for disease diagnosis. © 2017 John Wiley & Sons Ltd.

  20. Appendicular Skeletal Muscle Mass Reference Values and the Peak Muscle Mass to Identify Sarcopenia among Iranian Healthy Population.

    Science.gov (United States)

    Shafiee, Gita; Ostovar, Afshin; Heshmat, Ramin; Keshtkar, Abbas Ali; Sharifi, Farshad; Shadman, Zhaleh; Nabipour, Iraj; Soltani, Akbar; Larijani, Bagher

    2018-01-01

    Sacopenia is a common problem in elderly with the adverse outcomes. The objective of this study was to estimate the peak appendicular skeletal muscle mass (ASM) and age of its attainment by sex among the Iranian population. A total of 691 men and women aged 18-94 years participated in this cross-sectional, population-based study in Bushehr, Iran. ASM was measured by dual X-ray absorptiometry. Cutoff points for men and women were established considering two standard deviations (SDs) below the mean values of the skeletal muscle index (SMI) for young reference groups. The relationship between ASM and age was described by the second-degree regression models. Two SDs below the mean SMIs of reference groups were as cutoff values of low muscle mass in Iranian population. The peak ASM values were 21.35 ± 0.12 Kg and 13.68 ± 0.10 Kg, and the age at peak ASM were 26 (24-28) years and 34 (33-35) years for men and women, respectively. Mean and SD of SMI in those ages were 7.01 ± 0.02 Kg/m 2 and 5.44 ± 0.02 Kg/m 2 among men and women, respectively. Calculated cutoff values of low muscle mass among the Iranian population were 7.0 Kg/m 2 and 5.4 Kg/m 2 among men and women, respectively. Iranian reference values of SMI for both genders were similar to Asia Working Group for Sarcopenia recommendation and lower than the United States and European values. Further studies from different nations and the Middle East countries are needed to obtain reference values for populations, enabling the researchers for comparison and also more valid reports on sarcopenia prevalence.

  1. Dietary and other lifestyle correlates of serum folate concentrations in a healthy adult population in Crete, Greece: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Scott John M

    2006-02-01

    Full Text Available Abstract Background Folate has emerged as a key nutrient for optimising health. Impaired folate status has been identified as a risk factor for cardiovascular disease, various types of cancers, and neurocognitive disorders. The study aimed at examining the distribution and determinants of serum folate concentrations in a healthy adult population in Crete, Greece. Methods A cross-sectional sample of 486 healthy adults (250 men, 236 women aged 39 ± 14 years, personnel of the Medical School and the University Hospital of Crete in Greece, was examined. Serum folate and vitamin B12 concentrations were measured by microbiological assay, and total homocysteine was determined fluorometrically and by high-pressure liquid chromatography. Lifestyle questionnaires were completed, and nutrient intakes and food consumption were assessed by 24-h dietary recalls. Multivariate analyses were performed using SPSS v10.1. Results The geometric mean (95% confidence interval concentrations of serum folate were 15.6 μmol/l (14.6–16.8 in men and 19.2 μmol/l (17.9–20.7 in women (p 1, and B6 were positively associated with serum folate. Consumption of potatoes, legumes, fruits, and vegetables were favourably related to the serum folate status. Conclusion Serum folate concentrations were associated with various demographic, lifestyle and dietary factors in healthy Cretan adults. Large-scale epidemiological studies should be conducted within the general Greek adult population to assess the prevalence of impaired folate status and further examine associations with dietary patterns and chronic disease risk. Considering the importance of folate in health maintenance, it is important to increase the public's awareness of modifiable lifestyle patterns and diet and tobacco use in particular, which may be associated with improved folate status.

  2. Reference interval for the disc-macula distance to disc diameter ratio in a large population of healthy Japanese adults: A prospective, observational study.

    Science.gov (United States)

    Sato, Ken-Ichi

    2017-04-01

    This study presents the calculated reference interval for the disc-to-macula distance to disc diameter ratio (DM:DD) based on a large population of healthy Japanese adults.A total of 308 consecutive, healthy Japanese adults were examined in this prospective observational study. Eighteen subjects were also excluded because of poor quality of the fundus photograph of one or both eyes; 290 (161 men and 129 women) were included in this study. For each subject, a color fundus photograph of one eye, either the right or left, was randomly selected and used for analysis. On the photograph, the distances between the fovea and the nearest temporal margin of the optic disc (Dft), and the two kinds of disc diameters (D1 and D2), which bisected at right angles and one of which was directed to the fovea (D1), were measured. DM:DD was estimated using the formula: (2Dft + D1)/(D1 + D2).The mean ± standard deviation of DM:DD was 2.91 ± 0.49 for men and 2.96 ± 0.54 for women; there was no sex difference (P = .78, Mann-Whitney U test). Also, almost no relationship was found between DM:DD and age (ρ = -.12, P = .04, Spearman's rank correlation coefficient). The data did not fit a normal distribution (P < .001, Kolmogorov-Smirnov test). The estimated reference interval for DM:DD corresponding to the 2.5th and 97.5th percentiles was 2.12 to 4.18.Using a nonparametric approach, the reference interval for DM:DD of a large population of healthy Japanese adults was calculated to be 2.12 to 4.18, regardless of age or sex.

  3. A STUDY ESTABLISHING THE IMPORTANCE OF BODY COMPOSITION ANALYSIS, REGULAR PHYSIOTHERAPY AND DIETARY MODIFICATIONS FOR INDEPENDENT AND HEALTHY LIVING AMONG GERIATRIC POPULATION: A DETAILED SYSTEMATIC REVIEW ARTICLE

    Directory of Open Access Journals (Sweden)

    Rohit Subhedar

    2015-10-01

    Full Text Available Background: This systematic review article aims towards comprehensive and elaborative collection of research articles related to the importance of body composition analysis, Physiotherapy and nutrition for independent geriatric lifestyle. The review article includes articles which suggest the importance of Body composition analysis, Physiotherapy interventions, specific exercises and a combination of fat free, fiber, fruit and fluid diet. Methods: A comprehensive electronic search was conducted using electronic databases Pub Med, MEDLINE, Google Scholar, Science Direct, Research gate, ICMJE, DOAJ, DRJI, IOSR, WAME and many others. In Total 3714, Research papers were reviewed which reported, Age ≥50 years, changes in Body composition in elderly , effects of Diet &Exercises on Body composition and effects of regular Physiotherapy in Geriatric health and obesity. Literature search was restricted to the studies conducted during 1980-2015. Results: Finally 55 papers along with references in research proposal were included. Review shows that ageing, body composition, Physiotherapeutic intervention and nutrition play an interdependent role in providing independent and healthy living among geriatric population. Conclusion: Combined and comprehensive interventions in form of periodic Body Composition Analysis, Physiotherapy interventions with Exercise therapy sessions and Nutritional Supplementation, will be more effective in combating ageing and independent healthy living among Geriatric population. Finally with this review we shall conclude that achieving perfect geriatric health depends upon awareness among the geriatric community to periodically analyze their body composition and regularly comply with exercise therapy sessions, subjective Physiotherapy modality sessions and nutritional supplementation. These principles help in achieving physically fit, healthy, happy and independent geriatric Community.

  4. Health status of Russian minorities in former Soviet Republics

    NARCIS (Netherlands)

    Groenewold, W.G.F.; van Ginneken, J.K.S.

    2011-01-01

    Objectives: To examine if, and to what extent, disparities in health status exist between ethnic Russians and the native majority populations of four former Soviet Republics; and to determine to what extent indicators of socio-economic status and lifestyle behaviours explain variations in health

  5. Diet Quality of Items Advertised in Supermarket Sales Circulars Compared to Diets of the US Population, as Assessed by the Healthy Eating Index-2010.

    Science.gov (United States)

    Jahns, Lisa; Scheett, Angela J; Johnson, LuAnn K; Krebs-Smith, Susan M; Payne, Collin R; Whigham, Leah D; Hoverson, Bonita S; Kranz, Sibylle

    2016-01-01

    Supermarkets use sales circulars to highlight specific foods, usually at reduced prices. Resulting purchases help form the set of available foods within households from which individuals and families make choices about what to eat. The purposes of this study were to determine how closely foods featured in weekly supermarket sales circulars conform to dietary guidance and how diet quality compares with that of the US population's intakes. Food and beverage items (n=9,149) in 52 weekly sales circulars from a small Midwestern grocery chain in 2009 were coded to obtain food group and nutrient and energy content. Healthy Eating Index-2010 (HEI-2010) total and component scores were calculated using algorithms developed by the National Cancer Institute. HEI-2010 scores for the US population aged 2+ years were estimated using data from the 2009-2010 National Health and Nutrition Examination Survey. HEI-2010 scores of circulars and population intakes were compared using Student's t tests. Mean total (42.8 of 100) HEI-2010 scores of circulars were lower than that of the US population (55.4; Pdiet quality. Supermarkets could support improvements in consumer diets by weekly featuring foods that are more in concordance with food and nutrient recommendations. Copyright © 2016 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

  6. Russian Science and Russian State: Image of a Scientist in Modern Russian Cinema

    Directory of Open Access Journals (Sweden)

    Svetlana M. Medvedeva

    2014-01-01

    Full Text Available The article analyses the image of a scientist represented in recent Russian movies. The article discusses two groups of questions: (1 nature and role of popular science in the life of society; (2 national features of scientific cultures. The article agues that popular science should not be conceived as a week copy of the real science. On the contrary, modern models of science communication assume that popular science have its own value and is able to influence scientific practices. Simultaneously we assume, that since popular science is less integrated with international scientific norms, it can easer reveal national traditions of scientific life. As a result, the analyze of recent Russian movies shows that the tradition established in Peter I times for Russian scientists to work out their self-identity in concern with Russian state still exists (scientist- state supporter/scientist- oppositionist. Actually the modern interpretation of dilemma between state patriotism and liberalism given by modern movies shows that Russian scientist don't have real choice, because they loose anyway whereas the state always wins. So owing to recent movies this representation of hopeless destiny of a scientist is becoming widespread in Russian public culture.

  7. Labor-force participation, policies & practices in an aging America: adaptation essential for a healthy & resilient population

    OpenAIRE

    Lisa F. Berkman; Axel Boersch-Supan; Mauricio Avendano

    2015-01-01

    Population aging in the United States poses challenges to societal institutions while simultaneously creating opportunities to build a more resilient, successful, and cohesive society. Work organization and labor-force participation are central to both the opportunities and challenges posed by our aging society. We argue that expectations about old age have not sufficiently adapted to the reality of aging today. Our institutions need more adaptation in order to successfully face the consequen...

  8. Population-based evaluation of the ‘LiveLighter’ healthy weight and lifestyle mass media campaign

    Science.gov (United States)

    Morley, B.; Niven, P.; Dixon, H.; Swanson, M.; Szybiak, M.; Shilton, T.; Pratt, I. S.; Slevin, T.; Hill, D.; Wakefield, M.

    2016-01-01

    The Western Australian (WA) ‘LiveLighter’ (LL) mass media campaign ran during June–August and September–October 2012. The principal campaign ad graphically depicts visceral fat of an overweight individual (‘why’ change message), whereas supporting ads demonstrate simple changes to increase activity and eat healthier (‘how’ to change message). Cross-sectional surveys among population samples aged 25–49 were undertaken pre-campaign (N = 2012) and following the two media waves (N = 2005 and N = 2009) in the intervention (WA) and comparison state (Victoria) to estimate the population impact of LL. Campaign awareness was 54% after the first media wave and overweight adults were more likely to recall LL and perceive it as personally relevant. Recall was also higher among parents, but equal between socio-economic groups. The ‘why’ message about health-harms of overweight rated higher than ‘how’ messages about lifestyle change, on perceived message effectiveness which is predictive of health-related intention and behaviour change. State-by-time interactions showed population-level increases in self-referent thoughts about the health-harms of overweight (P campaign impact. However, sustained campaign activity will be needed to impact behaviour. PMID:26956039

  9. Hepatitis E virus and hepatitis A virus exposures in an apparently healthy high-risk population in Italy.

    Science.gov (United States)

    Rapicetta, M; Monarca, R; Kondili, L A; Chionne, P; Madonna, E; Madeddu, G; Soddu, A; Candido, A; Carbonara, S; Mura, M S; Starnini, G; Babudieri, S

    2013-02-01

    The prevalence of anti-hepatitis E virus (HEV) and anti-hepatitis A virus (HAV), as well as the possible links with socio-demographic and other viral risks factors, were evaluated in an inmates population. The study population consisted of 973 consecutively recruited inmates of eight Italian prisons. The anti-HEV prevalence was 11.6 % (113/973). It increased significantly by age (χ(2) for linear trend: p = 0.001) and was significantly higher among non-Italian compared to Italian inmates (15.3 vs. 10.7 %, respectively). Age >40 years [odds ratio (OR) 2.1; 95 % confidence interval (CI) 1.4-3.1], non-Italian citizenship (OR 1.8; 95 % CI 1.1-2.9) and anti-HIV seropositivity (OR 2.2; 95 % CI 1.2-4.2) were the only factors independently associated to anti-HEV positivity by logistic regression analysis. The overall anti-HAV prevalence was 86.4 %, and was significantly higher in non-Italian compared to Italian prisoners (92.6 vs. 84.9 %, respectively; p = 0.02). Age older than 40 years (OR 3.6; 95 % CI 2.2-5.9), <5 years formal education (OR 2.1; 95 % CI 1.3-3.2) and non-Italian nationality (OR 2.7; 95 % CI 1.5-4.8) were factors independently associated to anti-HAV positivity by the logistic regression analysis. Compared to the general population, significantly higher anti-HEV and anti-HAV prevalences were observed in an inmates population in Italy. Old age and non-Italian nationality were factors independently related to both HEV and HAV exposures. This data suggest the important role of low socio-economic factors in the transmission of both infections in high-risk populations. The possible epidemiological and/or pathogenetic links between HEV and HIV exposures need to be studied further.

  10. Seroepizootiology of the herpesvirus Papio (HVP) infection in healthy baboons (Papio hamadryas) of high- and low-lymphoma risk populations.

    Science.gov (United States)

    Voevodin, A F; Ponomarjeva, T I; Lapin, B A

    1985-01-01

    Seroepizootiology of Herpesvirus Papio (HVP) infection was studied in three groups of healthy hamadryas baboons (Papio hamadryas): the main Sukhumi (high-lymphoma) stock, forest Sukhumi (lymphoma-free) stock and newly imported wild animals. The prevalence to HVP infection, as judged by anti-VCA-HVP positivity, was approximately the same in both Sukhumi stocks (86% and 90% respectively) and it was significantly lower in the pooled group of newly imported baboons. It is interesting that prevalence of HVP infection in the different independent groups varied markedly (35-79%). Geometric mean titers of positives in all groups were approximately the same. The prevalence of HVP infection was age-dependent. It increased during the first years of life reaching the maximum (about 100%) at the age of 5 years being stable up to the age of 18 years and "decreased" at very old ages (over 18 years). The prevalence of HVP infection in newly imported baboons increased with age up to 71% in a group of the "oldest" monkeys and did not plateau. No significant sex differences in anti-HVP titers were found. Anti-EA-HVP-positive (with one exception) and anti-HUPNA-positive animals were found only in the main Sukhumi stock. Thus, "serologic activity" against HVP infection was the highest in the ligh-lymphoma stock.

  11. The relationship between nut consumption and lipid profile among the Iranian adult population; Isfahan Healthy Heart Program.

    Science.gov (United States)

    Askari, G; Yazdekhasti, N; Mohammadifard, N; Sarrafzadegan, N; Bahonar, A; Badiei, M; Sajjadi, F; Taheri, M

    2013-04-01

    The study was carried out to assess the relationship between nut consumption and lipid profile among Iranian adults. The study was based on data from the Isfahan Healthy Heart Program across three counties in central Iran in 2007. A cross-sectional survey of 9660 randomly selected adults aged ≥ 19 years were chosen based on sex, age and settlement distributions in each community. Nutritional behaviors were assessed by validated qualitative 48-item food frequency questionnaires, which covered regular intakes of four types of nuts: walnuts, almonds, pistachios and hazelnuts. Analysis of covariance and logistic regression tests were utilized to determine odds ratio (OR) 95% confidence interval of hyperlipidemia according to nut consumption patterns in unadjusted and three-adjusted models. The results showed a significant link between high nut consumption and lower total cholesterol, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) levels and apo B/apo A ratio (Pconsumption was inversely associated with dyslipidemia, especially for those who had consumed nuts ≥ 4 times weekly (0.67 (0.57-0.79)). After adjusting for sex, age and other potential confounders, ORs increased enormously. Except for low apo A and high LDL-C, more frequent nut consumption (4 ≤ times per week) had a significant inverse effect on other dyslipidemia risk factors in all four models. We concluded that frequent consumption of nuts, particularly ≥ 4 times a week, may result in lower dyslipidemia occurrences and may exert cardioprotective effects.

  12. [Glutamate receptors genes polymorphism and the risk of paranoid schizophrenia in Russians and tatars from the Republic of Bashkortostan].

    Science.gov (United States)

    Gareeva, A E; Khusnutdinova, E K

    2014-01-01

    Schizophrenia is a severe mental disorder that affects about 1% of the world population, leading to disability and social exclusion. Glutamatergic neurotransmission is a violation of one of the main hypotheses put forward to explain the neurobiological mechanisms of schizophrenia. Post mortem studies have found changes in the degree of affinity glutamate receptors, their transcription, and altered expression of their subunits in the prefrontal cortex, hippocampus, and thalamus in patients with schizophrenia. As a result of genetic studies of gene family encoding ionotropic AMPA and kainate glutamate receptors in schizophrenia, ambiguous results were received. The association of polymorphic variants of genes GRIA2 and GRIK2 with paranoid schizophrenia and response to therapy with haloperidol in Russian and Tatar of the Republic of Bashkortostan was conducted in the present study. DNA samples of 257 patients with paranoid schizophrenia and of 349 healthy controls of Russian and Tatar ethnic group living in the Republic of Bashkortostan were involved into the present study. In the result of the present study: (1) high risk genetic markers of paranoid schizophrenia (PSZ) were obtained: in Russians-GR4IA2*CCC (OR = 9.60) and in Tatars-GRIK2*ATG (OR = 3.5), GRIK2*TGG (OR = 3.12) (2) The following low risk genetic markers of PSZ were revealed: in Tatars-GRIA2*T/T (rs43025506) of GRIA2 gene (OR = 0.34); in Russians.- GRIA2*CCT (OR = 0.481). (3) Genetic markers of low haloperido! treatment efficacy in respect of negative and positive symptoms GRIK2*T/T (rs2227281) of GRIK2 gene and GRAL42*C/C in Russians, GRIK2*A/A (rs995640) of GRIK2 gene in Tatars. (4) Genetic markers of low haloperidol treatment efficacy in respect of positive symptoms GRL42*C/C in Russians. The results of the present study support the hypothesis of the involvement of glutamate receptor genes in schizophrenia pathway. Considerable inter-ethnic'diversity of genetic risk factors for this disease was

  13. Parkinson's disease: the reliability of morbidity and mortality statistics in the Russian Federation

    Directory of Open Access Journals (Sweden)

    Krivonos O.V.

    2013-12-01

    Full Text Available The aim of the research was to study the significance of morbidity of Parkinson's disease (PD and mortality in Russian Federation in international comparisons. Material and Methods: In accordance with the purpose of the study the morbidity and mortality were analyzed in the Russian Federation on the basis of volumes "Morbidity in Russia" of the Ministry of Health of the Russian Federation in 2009-2012, "Human resources for health care institutions" of the Ministry of Health of the Russian Federation in 2012, tables С 51 about the mortality of subjects of the Russian Federation in 2012, data of mortality from Parkinson's disease in different countries in 2011, published by WHO. Results. The analysis of data on the morbidity patterns showed that in the Russian Federation in 2009-2012 there was an increase in general morbidity of adult patients with PD from 75.1 to 87.7 per thousand of populations. The data of primary morbidity in the adult population of the Russian Federation from PD also tend to increase from 8.0 to 8.5 per thousand of populations. The sharp fluctuations of mortality's data were revealed in subject of Russian Federation that was related of unreliable data. Mortality from PD in Russian Federation in 2012 was 0.31 per thousand of populations. Conclusion. The values in the study of general and primary PD's morbidity in the Russian Federation were lower than performance in international comparisons. PD's mortality in Russia was also lower than in other developed countries. Abidance by rules of selecting the primary cause of death (PCOD, confirmed by an automated system, where one of the causes is PD will make mortality statistics of PD reliable and internationally comparable.

  14. Comprehensive multi-stage linkage analyses identify a locus for adult height on chromosome 3p in a healthy Caucasian population.

    Science.gov (United States)

    Ellis, Justine A; Scurrah, Katrina J; Duncan, Anna E; Lamantia, Angela; Byrnes, Graham B; Harrap, Stephen B

    2007-04-01

    There have been a number of genome-wide linkage studies for adult height in recent years. These studies have yielded few well-replicated loci, and none have been further confirmed by the identification of associated gene variants. The inconsistent results may be attributable to the fact that few studies have combined accurate phenotype measures with informative statistical modelling in healthy populations. We have performed a multi-stage genome-wide linkage analysis for height in 275 adult sibling pairs drawn randomly from the Victorian Family Heart Study (VFHS), a healthy population-based Caucasian cohort. Height was carefully measured in a standardised fashion on regularly calibrated equipment. Following genome-wide identification of a peak Z-score of 3.14 on chromosome 3 at 69 cM, we performed a fine-mapping analysis of this region in an extended sample of 392 two-generation families. We used a number of variance components models that incorporated assortative mating and shared environment effects, and we observed a peak LOD score of approximately 3.5 at 78 cM in four of the five models tested. We also demonstrated that the most prevalent model in the literature gave the worst fit, and the lowest LOD score (2.9) demonstrating the importance of appropriate modelling. The region identified in this study replicates the results of other genome-wide scans of height and bone-related phenotypes, strongly suggesting the presence of a gene important in bone growth on chromosome 3p. Association analyses of relevant candidate genes should identify the genetic variants responsible for the chromosome 3p linkage signal in our population.

  15. Age-Specific Normal Reference Range for Serum Anti-Müllerian Hormone in Healthy Chinese Han Women: A nationwide Population-Based Study.

    Science.gov (United States)

    Du, Xiaofang; Ding, Ting; Zhang, Hanwang; Zhang, Cuilian; Ma, Wenmin; Zhong, Ying; Qu, Wenyu; Zheng, Jie; Liu, Yi; Li, Zhiying; Huang, Kecheng; Deng, Song; Ma, Lanfang; Yang, Jun; Jiang, Jingjing; Yang, Shuhong; Huang, Jia; Wu, Meng; Fang, Li; Lu, Yunping; Luo, Aiyue; Wang, Shixuan

    2016-08-01

    The increasing use of anti-Müllerian hormone (AMH) in clinic has raised concerns regarding the reliable reference range for this test. However, the reference range for AMH in normal Chinese female population has not been established. Furthermore, relationship between AMH and other clinical markers such as body mass index (BMI) and antral follicle counts (AFCs) and other sex-related hormones have not been examined in normal population-based women. We aimed to determine the age-specific reference range for serum AMH in healthy Chinese women throughout reproductive age to menopause and to estimate relationship between AMH and other clinical markers in healthy women. In this multicenter and nationwide study, advertisements were used to recruit 2055 women, aged 20 to 55 years, from 6 different regions in China; 1590 (77.37%) women met the inclusion criteria for the reference range population. We measured the baseline serum AMH levels using new Beckman Coulter Gen II assay. Serum concentration of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T), prolactin (PRL), progesterone (PRG), and AFCs were also determined in the follicular phase. The AMH-Age nomogram and AMH levels of different age-groups and the relationship between AMH and other clinical markers. Serum AMH concentrations declined progressively with age. A quadratic model defined as log (AMH) = (-1.970 + 0.296 × Age - 0.006 × Age(2)) fitted best the decline of AMH with age. The median AMH levels were 6.23, 5.65, 4.55, 3.74, 2.78, and 1.09 ng/mL for the 20 ≤ age women. © The Author(s) 2016.

  16. Accuracy and reliability of thyroid volumetry using spiral CT and thyroid volume in a healthy, non-iodine-deficient Chinese adult population

    Energy Technology Data Exchange (ETDEWEB)

    Shu Jian, E-mail: shujiannc@163.com [Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, 74 Linjiang Road, Yuzhong District, Chongqing 400010 (China); Zhao Jiannong, E-mail: zhaojiannong@tom.com [Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, 74 Linjiang Road, Yuzhong District, Chongqing 400010 (China); Guo Dajing, E-mail: guodaj@163.com [Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, 74 Linjiang Road, Yuzhong District, Chongqing 400010 (China); Luo Yindeng, E-mail: yindengluo_1019@163.com [Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, 74 Linjiang Road, Yuzhong District, Chongqing 400010 (China); Zhong Weijia, E-mail: zhongweijia2003@eyou.com [Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, 74 Linjiang Road, Yuzhong District, Chongqing 400010 (China); Xie Weibo, E-mail: radiologycq@163.com [Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, 74 Linjiang Road, Yuzhong District, Chongqing 400010 (China)

    2011-02-15

    Objective: The purpose of this study was to assess the accuracy and reliability of thyroid volumetry using spiral CT and to investigate thyroid volumes for a healthy, non-iodine-deficient adult population in southwestern region of China. Materials and methods: Spiral CT was performed in phantoms and adult subjects with normal thyroid, and the volumes were measured by observers with 5 years or more of CT experience. The phantom volumes and the thyroid volumes of all subjects were noted. Results: For the thyroid phantoms, there was no significant difference between the true and CT calculated volumes (t = 0.862, P = 0.399), and the correlation was excellent (ICC = 0.9995, P = 0.000). In the subjects for reliability analysis, the intraobserver or interobserver differences for CT volumetric measurement of thyroid were not significant (P > 0.05). The intraobserver or interobserver correlations were very high (ICC > 0.99, P < 0.001). In the subjects for population analysis, the median of the thyroid volumes was 11.45 cm{sup 3}. The nonparametric Mann-Whitney U-test showed no significant difference for the thyroid volume between sexes (U = 4388.00, Z = -1.118, P = 0.264). The nonparametric Kruskall-Wallis test showed no significant difference in all age groups ({chi}{sup 2} = 13.466, P = 0.062). There was a slight negative correlation between the thyroid volume and age (r{sub s} = -0.166, P = 0.019). Conclusion: The accuracy and reliability of multi-slice spiral CT in measuring thyroid volume are very high. The thyroid volumes are not significantly difference between genders or among decades for the healthy, non-iodine-deficient adult population in southwestern region of China.

  17. Finnish Factor in the History of the Northern Frontier of the Russian Empire 1809–1855

    Directory of Open Access Journals (Sweden)

    Konstantin S. Zaikov

    2016-09-01

    Full Text Available The article is devoted to the little-known pages of the "Northern Frontier" history – the Russian-Norwegian border zone, namely the role of the Grand Duchy of Finland in the border policy of the Russian Empire and the Swedish-Norwegian in the border area in 1809–1855. The authors demonstrate that in 1809 the entry of Finland into the Russian Empire strengthened its ability to defend national interests in the far north of Europe. At the same time, the growing influence of the Grand Duchy on the Russian home and foreign policy contributed to the total indoctrination of the Russian-Swedish/Norwegian border and the image of the "Russian threat", which was distributed among the political elite of the Swedish-Norwegian state in the 1820–1850s. Distribution of russophobian sentiments in the United Kingdom of Sweden and Norway accelerated the urgency of the Northern Frontier formal delimitation for the Russian-Swedish diplomatic relations in the first half of the 1820s. The "Russian threat" also served the ideological basis for gradual securitization and politicization of the Russian-Norwegian border area. Thus, the United Kingdom of Sweden and Norway viewed the whole range of cross-border relations between the population of Finnmark (Sweden-Norway, Uleåborg province (Grand Duchy of Finland and the Arkhangelsk province (Russian Empire as one of the potential threats to national security in the second half of the 19th century. The closure of the Finnish-Norwegian section of the Russian-Swedish/Norwegian border in 1852 and joining the anti-Russian coalition with Britain and France, formally enshrined in the so-called the November Treaty of 1855, become the culmination of this process.

  18. Factors related to serum level of carbohydrate antigen 19-9 and cancer antigen 125 in healthy rural populations in Korea

    International Nuclear Information System (INIS)

    Lee, S. K.; Yoo, K. Y.; Park, S. K.; Kang, D. H.; Kim, J. K.; Jeong, Z. K.; Lee, M. C.

    1998-01-01

    This study examines the levels of carbohydrate antigen 19-9(CA 19-9) and cancer antigen 125(CA125) in serum and its related factors in healthy Korean population. Although CA19-9 and CA125 have been widely used tumor markers for gastroenteric cancers and ovarian cancer in Western countries, there are no information available on the serum levels of CA19-9 and CA125 in healthy population and the factors affecting the levels of these tumor markers in Korea. A cross-sectional study was performed to measure CA19-9 and CA125 among 76 healthy males and 95 healthy females in Korea. CA19-9 and CA125 were quantitated using solid-phase radioimmunoassay kits. Informations on the factors which might be related to the levels of these markers were collected by questionnaire(e.g., smoking, alcohol consumption, menstruation, oral pill use, breast-feeding history, etc.). There was no statistically significant difference in the mean of CA19-9 concentration between men(10.4 u/ml) and women (10.1 u/ml), whereas the mean of CA125 levels (11.2 u/ml) was higher in women than that(2.5 u/ml) in men. Although there was a statistically significant association between CA19-9 and average number of cigarette consumed per day (r=0.59, p=0.026) and total number of cigarettes consumed in women (r=0.74, p=0.003), the significance disappeared by multiple regression analysis after adjusting age and body mass index. Later age of menopause(p=0.035) and longer duration of breast-feeding(p=0.050) were significant predictors for CA125 levels in women by multiple regression analysis after adjusting age and body mass index. In conclusion, CA19-9 can be used as a stable tumor marker in clinical practices, however, menstruation and breast-feeding should be considered when CA125 is used in women

  19. Factors related to serum level of carbohydrate antigen 19-9 and cancer antigen 125 in healthy rural populations in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S. K.; Yoo, K. Y.; Park, S. K.; Kang, D. H.; Kim, J. K.; Jeong, Z. K.; Lee, M. C. [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of)

    1998-01-01

    This study examines the levels of carbohydrate antigen 19-9(CA 19-9) and cancer antigen 125(CA125) in serum and its related factors in healthy Korean population. Although CA19-9 and CA125 have been widely used tumor markers for gastroenteric cancers and ovarian cancer in Western countries, there are no information available on the serum levels of CA19-9 and CA125 in healthy population and the factors affecting the levels of these tumor markers in Korea. A cross-sectional study was performed to measure CA19-9 and CA125 among 76 healthy males and 95 healthy females in Korea. CA19-9 and CA125 were quantitated using solid-phase radioimmunoassay kits. Informations on the factors which might be related to the levels of these markers were collected by questionnaire(e.g., smoking, alcohol consumption, menstruation, oral pill use, breast-feeding history, etc.). There was no statistically significant difference in the mean of CA19-9 concentration between men(10.4 u/ml) and women (10.1 u/ml), whereas the mean of CA125 levels (11.2 u/ml) was higher in women than that(2.5 u/ml) in men. Although there was a statistically significant association between CA19-9 and average number of cigarette consumed per day (r=0.59, p=0.026) and total number of cigarettes consumed in women (r=0.74, p=0.003), the significance disappeared by multiple regression analysis after adjusting age and body mass index. Later age of menopause(p=0.035) and longer duration of breast-feeding(p=0.050) were significant predictors for CA125 levels in women by multiple regression analysis after adjusting age and body mass index. In conclusion, CA19-9 can be used as a stable tumor marker in clinical practices, however, menstruation and breast-feeding should be considered when CA125 is used in women.

  20. Physical activity in community-dwelling stroke survivors and a healthy population is not explained by motor function only.

    Science.gov (United States)

    Danielsson, Anna; Meirelles, Cristiane; Willen, Carin; Sunnerhagen, Katharina Stibrant

    2014-02-01

    To explore the relationship between self-reporting and physical measures and compare self-reported physical activity (PA) levels in persons who have had a stroke with self-reported PA levels in a control population. Cross-sectional assessment of a convenience sample of survivors of a stroke living in the community and a population-based sample from the same community. University hospital. Seventy persons (48 men and 22 women; average age, 60 years) who had a stroke a mean of 6 years earlier and 141 persons (70 men and 71 women; average age, 59 years) who served as control subjects. The Physical Activity Scale for the Elderly (PASE) was used, and self-selected and maximum walking speeds were measured. Motor function after stroke was assessed with the Fugl-Meyer Assessment. The median Fugl-Meyer score for motor function in the leg was 29. Mean self-selected and maximum walking speeds after having a stroke were 1.0 m/s and 1.3 m/s, corresponding to 72% and 65% of control values. A regression model with PASE as the dependent variable and age and walking speed as independent variables explained 29% (P physically active than the population of the same age who have not had a stroke. However, it appears that factors other than motor impairment have an impact on a person's PA level, because only a low association was found between PA level and motor function, with a large dispersion in PA levels in persons with a history of stroke who were physically well recovered. Copyright © 2014 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

  1. Investigation and functional characterization of rare genetic variants in the adipose triglyceride lipase in a large healthy working population.

    Directory of Open Access Journals (Sweden)

    Stefan Coassin

    2010-12-01

    Full Text Available Recent studies demonstrated a strong influence of rare genetic variants on several lipid-related traits. However, their impact on free fatty acid (FFA plasma concentrations, as well as the role of rare variants in a general population, has not yet been thoroughly addressed. The adipose triglyceride lipase (ATGL is encoded by the PNPLA2 gene and catalyzes the rate-limiting step of lipolysis. It represents a prominent candidate gene affecting FFA concentrations. We therefore screened the full genomic region of ATGL for mutations in 1,473 randomly selected individuals from the SAPHIR (Salzburg Atherosclerosis Prevention program in subjects at High Individual Risk Study using a combined Ecotilling and sequencing approach and functionally investigated all detected protein variants by in-vitro studies. We observed 55 novel mostly rare genetic variants in this general population sample. Biochemical evaluation of all non-synonymous variants demonstrated the presence of several mutated but mostly still functional ATGL alleles with largely varying residual lipolytic activity. About one-quarter (3 out of 13 of the investigated variants presented a marked decrease or total loss of catalytic function. Genetic association studies using both continuous and dichotomous approaches showed a shift towards lower plasma FFA concentrations for rare variant carriers and an accumulation of variants in the lower 10%-quantile of the FFA distribution. However, the generally rather small effects suggest either only a secondary role of rare ATGL variants on the FFA levels in the SAPHIR population or a recessive action of ATGL variants. In contrast to these rather small effects, we describe here also the first patient with "neutral lipid storage disease with myopathy" (NLSDM with a point mutation in the catalytic dyad, but otherwise intact protein.

  2. Long-term effects of an exercise and Mediterranean diet intervention in the vascular function of an older, healthy population.

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    Klonizakis, Markos; Alkhatib, Ahmad; Middleton, Geoff

    2014-09-01

    Preserving endothelial function and microvascular integrity is suggested to reduce cardiovascular disease risk. It was recently shown that the age-dependent decline in endothelial and microvascular integrity may be reversed when combining exercise with Mediterranean diet (MD) in an 8-week intervention. The present study investigates whether the risk-reduction improvement in microcirculatory and cardiorespiratory functions are sustained in this age-group after a 1-year follow-up. Twenty sedentary healthy participants (age, 55±4years) from the original study underwent cardiopulmonary exercise tolerance test and were assessed for their upper- and lower-limb vascular endothelial cutaneous vascular conductance (CVC) using laser Doppler fluximetry (LDF) with endothelium-dependent [ACh (acetylcholine chloride)] and endothelium-independent [SNP (sodium nitroprusside)] vasodilation, 1year after completing the intervention. Both MD and exercise groups appeared to have an improved microvascular responses, in comparison to baseline as far as ACh is concerned. Exploring the interactions between the time point and the original group, however, revealed a stronger improvement in the MD group in comparison to the exercise group, for ACh (p=0.04, d=0.41). In the upper body, the time point and group interaction for ACh, indicated a better improvement for MD, without however statistical significance (p=0.07, d=0.24). Additionally, cardiorespiratory improvement in ventilatory threshold was maintained, 1year after (12.2±3.0 vs. 13.2±3.2ml∙kg(-1)∙min(-1), pexercise and MD intervention were still evident, particularly in the microcirculatory and cardiorespiratory assessments, 1year after the initial study. This suggests that a brief intervention combining MD with exercise in this high-risk group promises long-term health benefits. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Quantifying kinematic differences between land and water during squats, split squats, and single-leg squats in a healthy population.

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    Severin, Anna C; Burkett, Brendan J; McKean, Mark R; Wiegand, Aaron N; Sayers, Mark G L

    2017-01-01

    Aquatic exercises can be used in clinical and sporting disciplines for both rehabilitation and sports training. However, there is limited knowledge on the influence of water immersion on the kinematics of exercises commonly used in rehabilitation and fitness programs. The aim of this study was to use inertial sensors to quantify differences in kinematics and movement variability of bodyweight squats, split squats, and single-leg squats performed on dry land and whilst immersed to the level of the greater trochanter. During two separate testing sessions, 25 active healthy university students (22.3±2.9 yr.) performed ten repetitions of each exercise, whilst tri-axial inertial sensors (100 Hz) recorded their trunk and lower body kinematics. Repeated-measures statistics tested for differences in segment orientation and speed, movement variability, and waveform patterns between environments, while coefficient of variance was used to assess differences in movement variability. Between-environment differences in segment orientation and speed were portrayed by plotting the mean difference ±95% confidence intervals (CI) throughout the tasks. The results showed that the depth of the squat and split squat were unaffected by the changed environment while water immersion allowed for a deeper single leg squat. The different environments had significant effects on the sagittal plane orientations and speeds for all segments. Water immersion increased the degree of movement variability of the segments in all exercises, except for the shank in the frontal plane, which showed more variability on land. Without compromising movement depth, the aquatic environment induces more upright trunk and shank postures during squats and split squats. The aquatic environment allows for increased squat depth during the single-leg squat, and increased shank motions in the frontal plane. Our observations therefore support the use of water-based squat tasks for rehabilitation as they appear to

  4. Quantifying kinematic differences between land and water during squats, split squats, and single-leg squats in a healthy population.

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    Anna C Severin

    Full Text Available Aquatic exercises can be used in clinical and sporting disciplines for both rehabilitation and sports training. However, there is limited knowledge on the influence of water immersion on the kinematics of exercises commonly used in rehabilitation and fitness programs. The aim of this study was to use inertial sensors to quantify differences in kinematics and movement variability of bodyweight squats, split squats, and single-leg squats performed on dry land and whilst immersed to the level of the greater trochanter. During two separate testing sessions, 25 active healthy university students (22.3±2.9 yr. performed ten repetitions of each exercise, whilst tri-axial inertial sensors (100 Hz recorded their trunk and lower body kinematics. Repeated-measures statistics tested for differences in segment orientation and speed, movement variability, and waveform patterns between environments, while coefficient of variance was used to assess differences in movement variability. Between-environment differences in segment orientation and speed were portrayed by plotting the mean difference ±95% confidence intervals (CI throughout the tasks. The results showed that the depth of the squat and split squat were unaffected by the changed environment while water immersion allowed for a deeper single leg squat. The different environments had significant effects on the sagittal plane orientations and speeds for all segments. Water immersion increased the degree of movement variability of the segments in all exercises, except for the shank in the frontal plane, which showed more variability on land. Without compromising movement depth, the aquatic environment induces more upright trunk and shank postures during squats and split squats. The aquatic environment allows for increased squat depth during the single-leg squat, and increased shank motions in the frontal plane. Our observations therefore support the use of water-based squat tasks for rehabilitation as

  5. Association of Animal and Plant Proteins Intake with Hypertension in Iranian Adult Population: Isfahan Healthy Heart Program

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    Sanaz Mehrabani

    2017-01-01

    Full Text Available Background: There is evidence regarding the relationship between dietary proteins intake and blood pressure (BP, but they had inconsistent results. Therefore, this study was designed to assess the association between different kinds of protein intake (animal and plant protein and BP. Materials and Methods: Data were collected from Isfahan Healthy Heart Program. We performed a cross-sectional study among 9660 randomly selected Iranian adults aged ≥19-year-old that they were selected from three large Iranian regions in 2007. A simplified validated 48-item-food frequency questionnaire was used to assess dietary intake including all kinds of protein. Systolic and diastolic BPs were measured in duplicate by trained personnel using a standard protocol. Multivariable regressions were applied to assess the relationship between protein intake and BP levels and the presence of hypertension (HTN. Results: More frequent consumption of animal, plant, and total protein intake were inversely associated with BP in a crude model (P < 0.001; however, after adjustment for potential confounders this relationship remained only for plant protein (P = 0.04. The risk of HTN occurrence decreased in the highest quintile of total and plant protein consumption by 19% (odds ratio [OR] = 0.81; confidence interval [CI]: [0.65–0.96]; P for trend = 0.004 and 18% (OR = 0.82; [CI: (0.67–0.94]; P for trend = 0.03, respectively. Conclusions: More frequent protein intake, especially plant protein consumption was inversely associated with BP and risk of HTN among Iranian adults.

  6. Influence of geomagnetic activity and earth weather changes on heart rate and blood pressure in young and healthy population.

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    Ozheredov, V A; Chibisov, S M; Blagonravov, M L; Khodorovich, N A; Demurov, E A; Goryachev, V A; Kharlitskaya, E V; Eremina, I S; Meladze, Z A

    2017-05-01

    There are many references in the literature related to connection between the space weather and the state of human organism. The search of external factors influence on humans is a multi-factor problem and it is well known that humans have a meteo-sensitivity. A direct problem of finding the earth weather conditions, under which the space weather manifests itself most strongly, is discussed in the present work for the first time in the helio-biology. From a formal point of view, this problem requires identification of subset (magnetobiotropic region) in three-dimensional earth's weather parameters such as pressure, temperature, and humidity, corresponding to the days when the human body is the most sensitive to changes in the geomagnetic field variations and when it reacts by statistically significant increase (or decrease) of a particular physiological parameter. This formulation defines the optimization of the problem, and the solution of the latter is not possible without the involvement of powerful metaheuristic methods of searching. Using the algorithm of differential evolution, we prove the existence of magnetobiotropic regions in the earth's weather parameters, which exhibit magneto-sensitivity of systolic, diastolic blood pressure, and heart rate of healthy young subjects for three weather areas (combinations of atmospheric temperature, pressure, and humidity). The maximum value of the correlation confidence for the measurements attributable to the days of the weather conditions that fall into each of three magnetobiotropic areas is an order of 0.006, that is almost 10 times less than the confidence, equal to 0.05, accepted in many helio-biological researches.

  7. Effectiveness of the mHealth technology in improvement of healthy behaviors in an elderly population-a systematic review.

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    Changizi, Maryam; Kaveh, Mohammad H

    2017-01-01

    Demographic changes in the 21st century, increased population of the elderly and high prevalence of related diseases call for new healthcare strategies that can change the behavior and lifestyle of elderly individuals. Innovative information and communication technology, such as mobile health (mHealth), can play a significant role. The present study was conducted aiming to assess the effectiveness of mHealth in improving health behaviors among an elderly population. This paper presents a systematic review involving a search of PubMed, Web of Science (ISI), Scopus, Science Direct and Embase databases from [2012-2016]. Our search resulted after initial evaluations 12 articles. Inclusion criteria mostly revolved around interventional studies, other studies were excluded because of their methodology, non-elderly target groups and irrelevant to the subject. Findings showed that mHealth can improve care, self-management, self-efficacy, behavior promotion (quality of sleep, diet, physical activity mental health) and medication adherence. The mHealth technology has proven effective for disease prevention, lifestyle changes, management of cardiovascular disease and diabetes, and is a suitable tool for elderly people. In conclusion, it seems that mHealth can facilitate behavioral changes; although, further research is necessary in this regard.

  8. Prevalence and clinical characteristics of metabolically healthy obese individuals and other obese/non-obese metabolic phenotypes in a working population: results from the Icaria study

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    Albert Goday

    2016-04-01

    Full Text Available Abstract Background Metabolically healthy obese (MHO phenotype may present with distinct characteristics compared with those with a metabolically unhealthy obese phenotype. Epidemiologic data on the distribution of these conditions in the working population are lacking. We aimed to evaluate the prevalence and clinical characteristics of MHO and other obese/non-obese metabolic phenotypes in a working population. Methods Cross-sectional analysis of all subjects who had undergone a medical examination with Ibermutuamur Prevention Society from May 2004 to December 2007. Participants were classified into 5 categories according to their body mass index (BMI; within each of these categories, participants were further classified as metabolically healthy (MH or metabolically unhealthy (MUH according to the modified NCEP-ATPIII criteria. A logistic regression analysis was performed to evaluate some clinically relevant factors associated with a MH status. Results In the overall population, the prevalence of the MHO phenotype was 8.6 %. The proportions of MH individuals in the overweight and obese categories were: 87.1 % (overweight and 55.5 % (obese I-III [58.8, 40.0, and 38.7 % of the obese I, II, and III categories, respectively]. When the overweight and obese categories were considered, compared with individuals who were MUH, those who were MH tended to be younger and more likely to be female or participate in physical exercise; they were also less likely to smoke, or to be a heavy drinker. In the underweight and normal weight categories, compared with individuals who were MH, those who were MUH were more likely to be older, male, manual (blue collar workers, smokers and heavy drinkers. Among participants in the MUH, normal weight group, the proportion of individuals with a sedentary lifestyle was higher relative to those in the MH, normal weight group. The factors more strongly associated with the MUH phenotype were BMI and age, followed by the

  9. Ethnic Motives in Russian Mass Consciousness

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    Natalija Pliskevič

    2000-12-01

    nation, which fuels nationalism. Yet Russian nationalism has not yet assumed a massive level, although the mass awareness of Russians is marked by a form of traditionalism, which manifests itself not so much in adherence to traditions, as in preventing the penetration of universal (foreign values. The author (N.P. further summarised some results on the level of anti-Semitism in Russia. In this regard she presents the conclusions of the American researcher, R. Brim, who found that after the 1998 devaluation of the ruble attitudes towards Jews were divided, but with a preponderance of the negative stance. Brim concluded that political factors and leaders had the most effect on the fate of Jews in Russia. At more stable times, as Gudkov claimed, the Russian attitude towards Jews was either positive or neutral, no different then the relationship to other ethnic groups and less negative than the attitudes of non-Russians, especially in the autonomous entities, to minorities (including Jews. All in all, one researcher (Zdravomyslov estimated that ethnic nationalism in Russian society effected no more than 10% of the population. The author (N.P. also summarises the results of some comparative analyses between Russia and other former Soviet republics. First, the image of the CIS as a threat to Russia has fallen in recent years and the great majority of Russians favour peaceful methods in regard to protecting the rights of Russian minorities in the former Soviet republics (Sedov. Comparative research in the Russia, the Baltic states and the Ukraine, shows that Russians and Estonians have similar attitudes to state paternalism and a similarly divided opinion on reforms and socialism (however state paternalism has more support in Russia and reforms are slightly more favoured in Estonian public opinion. As to social fears, comparative study of public opinion in Lithuania, Russia and the Ukraine showed that respondents in Lithuania felt relatively the least social fears, while those

  10. Hand-to-Hand Model for Bioelectrical Impedance Analysis to Estimate Fat Free Mass in a Healthy Population.

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    Lu, Hsueh-Kuan; Chiang, Li-Ming; Chen, Yu-Yawn; Chuang, Chih-Lin; Chen, Kuen-Tsann; Dwyer, Gregory B; Hsu, Ying-Lin; Chen, Chun-Hao; Hsieh, Kuen-Chang

    2016-10-21

    This study aimed to establish a hand-to-hand (HH) model for bioelectrical impedance analysis (BIA) fat free mass (FFM) estimation by comparing with a standing position hand-to-foot (HF) BIA model and dual energy X-ray absorptiometry (DXA); we also verified the reliability of the newly developed model. A total of 704 healthy Chinese individuals (403 men and 301 women) participated. FFM (FFM DXA ) reference variables were measured using DXA and segmental BIA. Further, regression analysis, Bland-Altman plots, and cross-validation (2/3 participants as the modeling group, 1/3 as the validation group; three turns were repeated for validation grouping) were conducted to compare tests of agreement with FFM DXA reference variables. In male participants, the hand-to-hand BIA model estimation equation was calculated as follows: FFM m HH = 0.537 h²/Z HH - 0.126 year + 0.217 weight + 18.235 ( r ² = 0.919, standard estimate of error (SEE) = 2.164 kg, n = 269). The mean validated correlation coefficients and limits of agreement (LOAs) of the Bland-Altman analysis of the calculated values for FFM m HH and FFM DXA were 0.958 and -4.369-4.343 kg, respectively, for hand-to-foot BIA model measurements for men; the FFM (FFM m HF ) and FFM DXA were 0.958 and -4.356-4.375 kg, respectively. The hand-to-hand BIA model estimating equation for female participants was FFM F HH = 0.615 h²/Z HH - 0.144 year + 0.132 weight + 16.507 ( r ² = 0.870, SEE = 1.884 kg, n = 201); the three mean validated correlation coefficient and LOA for the hand-to-foot BIA model measurements for female participants (FFM F HH and FFM DXA ) were 0.929 and -3.880-3.886 kg, respectively. The FFM HF and FFM DXA were 0.942 and -3.511-3.489 kg, respectively. The results of both hand-to-hand and hand-to-foot BIA models demonstrated similar reliability, and the hand-to-hand BIA models are practical for assessing FFM.

  11. Hand-to-Hand Model for Bioelectrical Impedance Analysis to Estimate Fat Free Mass in a Healthy Population

    Directory of Open Access Journals (Sweden)

    Hsueh-Kuan Lu

    2016-10-01

    Full Text Available This study aimed to establish a hand-to-hand (HH model for bioelectrical impedance analysis (BIA fat free mass (FFM estimation by comparing with a standing position hand-to-foot (HF BIA model and dual energy X-ray absorptiometry (DXA; we also verified the reliability of the newly developed model. A total of 704 healthy Chinese individuals (403 men and 301 women participated. FFM (FFMDXA reference variables were measured using DXA and segmental BIA. Further, regression analysis, Bland–Altman plots, and cross-validation (2/3 participants as the modeling group, 1/3 as the validation group; three turns were repeated for validation grouping were conducted to compare tests of agreement with FFMDXA reference variables. In male participants, the hand-to-hand BIA model estimation equation was calculated as follows: FFMmHH = 0.537 h2/ZHH − 0.126 year + 0.217 weight + 18.235 (r2 = 0.919, standard estimate of error (SEE = 2.164 kg, n = 269. The mean validated correlation coefficients and limits of agreement (LOAs of the Bland–Altman analysis of the calculated values for FFMmHH and FFMDXA were 0.958 and −4.369–4.343 kg, respectively, for hand-to-foot BIA model measurements for men; the FFM (FFMmHF and FFMDXA were 0.958 and −4.356–4.375 kg, respectively. The hand-to-hand BIA model estimating equation for female participants was FFMFHH = 0.615 h2/ZHH − 0.144 year + 0.132 weight + 16.507 (r2 = 0.870, SEE = 1.884 kg, n = 201; the three mean validated correlation coefficient and LOA for the hand-to-foot BIA model measurements for female participants (FFMFHH and FFMDXA were 0.929 and −3.880–3.886 kg, respectively. The FFMHF and FFMDXA were 0.942 and −3.511–3.489 kg, respectively. The results of both hand-to-hand and hand-to-foot BIA models demonstrated similar reliability, and the hand-to-hand BIA models are practical for assessing FFM.

  12. Test-retest reliability and longitudinal analysis of automated hippocampal subregion volumes in healthy ageing and Alzheimer's disease populations.

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    Worker, Amanda; Dima, Danai; Combes, Anna; Crum, William R; Streffer, Johannes; Einstein, Steven; Mehta, Mitul A; Barker, Gareth J; C R Williams, Steve; O'daly, Owen

    2018-04-01

    The hippocampal formation is a complex brain structure that is important in cognitive processes such as memory, mood, reward processing and other executive functions. Histological and neuroimaging studies have implicated the hippocampal region in neuropsychiatric disorders as well as in neurodegenerative diseases. This highly plastic limbic region is made up of several subregions that are believed to have different functional roles. Therefore, there is a growing interest in imaging the subregions of the hippocampal formation rather than modelling the hippocampus as a homogenous structure, driving the development of new automated analysis tools. Consequently, there is a pressing need to understand the stability of the measures derived from these new techniques. In this study, an automated hippocampal subregion segmentation pipeline, released as a developmental version of Freesurfer (v6.0), was applied to T1-weighted magnetic resonance imaging (MRI) scans of 22 healthy older participants, scanned on 3 separate occasions and a separate longitudinal dataset of 40 Alzheimer's disease (AD) patients. Test-retest reliability of hippocampal subregion volumes was assessed using the intra-class correlation coefficient (ICC), percentage volume difference and percentage volume overlap (Dice). Sensitivity of the regional estimates to longitudinal change was estimated using linear mixed effects (LME) modelling. The results show that out of the 24 hippocampal subregions, 20 had ICC scores of 0.9 or higher in both samples; these regions include the molecular layer, granule cell layer of the dentate gyrus, CA1, CA3 and the subiculum (ICC > 0.9), whilst the hippocampal fissure and fimbria had lower ICC scores (0.73-0.88). Furthermore, LME analysis of the independent AD dataset demonstrated sensitivity to group and individual differences in the rate of volume change over time in several hippocampal subregions (CA1, molecular layer, CA3, hippocampal tail, fissure and presubiculum

  13. The effect of three different exercise training modalities on cognitive and physical function in a healthy older population.

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    Coetsee, Carla; Terblanche, Elmarie

    2017-01-01

    Older adults are encouraged to participate in regular physical activity to counter the age-related declines in physical and cognitive health. Literature on the effect of different exercise training modalities (aerobic vs resistance) on these health-related outcomes is not only sparse, but results are inconsistent. In general, it is believed that exercise has a positive effect on executive cognitive function, possibly because of the physiological adaptations through increases in fitness. Indications are that high-intensity interval training is a potent stimulus to improve cardiovascular fitness, even in older adults; however, its effect on cognitive function has not been studied before. Therefore, the purpose of this study was to compare the effects of resistance training, high-intensity aerobic interval training and moderate continuous aerobic training on the cognitive and physical functioning of healthy older adults. Sixty-seven inactive individuals (55 to 75 years) were randomly assigned to a resistance training (RT) group ( n  = 22), high-intensity aerobic interval training (HIIT) group ( n  = 13), moderate continuous aerobic training (MCT) group ( n  = 13) and a control (CON) group ( n  = 19) for a period of 16 weeks. Cognitive function was assessed with a Stroop task and physical function with the Timed-Up-and-Go (TUG) and submaximal Bruce treadmill tests. No significant GROUP x TIME interaction was found for Stroop reaction time ( P  > .05). The HIIT group showed the greatest practical significant improvement in reaction time on the information processing task, i.e. Stroop Neutral (ES = 1.11). MCT group participants had very large practical significant improvements in reaction time on the executive cognitive tasks, i.e. Stroop Incongruent and Interference (ES = 1.28 and 1.31, respectively). The HIIT group showed the largest practically significant increase in measures of physical function, i.e. walking endurance (ES = 0.91) and functional

  14. High throughput measurement of γH2AX DSB repair kinetics in a healthy human population.

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    Preety M Sharma

    Full Text Available The Columbia University RABiT (Rapid Automated Biodosimetry Tool quantifies DNA damage using fingerstick volumes of blood. One RABiT protocol quantifies the total γ-H2AX fluorescence per nucleus, a measure of DNA double strand breaks (DSB by an immunofluorescent assay at a single time point. Using the recently extended RABiT system, that assays the γ-H2AX repair kinetics at multiple time points, the present small scale study followed its kinetics post irradiation at 0.5 h, 2 h, 4 h, 7 h and 24 h in lymphocytes from 94 healthy adults. The lymphocytes were irradiated ex vivo with 4 Gy γ rays using an external Cs-137 source. The effect of age, gender, race, ethnicity, alcohol use on the endogenous and post irradiation total γ-H2AX protein yields at various time points were statistically analyzed. The endogenous γ-H2AX levels were influenced by age, race and alcohol use within Hispanics. In response to radiation, induction of γ-H2AX yields at 0.5 h and peak formation at 2 h were independent of age, gender, ethnicity except for race and alcohol use that delayed the peak to 4 h time point. Despite the shift in the peak observed, the γ-H2AX yields reached close to baseline at 24 h for all groups. Age and race affected the rate of progression of the DSB repair soon after the yields reached maximum. Finally we show a positive correlation between endogenous γ-H2AX levels with radiation induced γ-H2AX yields (RIY (r=0.257, P=0.02 and a negative correlation with residuals (r=-0.521, P=<0.0001. A positive correlation was also observed between RIY and DNA repair rate (r=0.634, P<0.0001. Our findings suggest age, race, ethnicity and alcohol use influence DSB γ-H2AX repair kinetics as measured by RABiT immunofluorescent assay.

  15. Using mass-media communications to increase population usage of Australia’s Get Healthy Information and Coaching Service®

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    O’Hara Blythe J

    2012-09-01

    Full Text Available Abstract Background Global obesity prevalence is increasing and population health programs are required to support changes to modifiable lifestyle risk factors. Such interventions benefit from mass-communications to promote their use. The Get Healthy Information and Coaching Service ® (GHS utilised mass-reach media advertising to recruit participants to an Australian state-wide program. Methods A stand alone population survey collected awareness, knowledge and behavioural variables before the first advertising phase, (n = 1,544; August -September 2010, during (n = 1,500; February - March 2011 and after the advertising period (n = 1,500; June-July 2011. GHS usage data (n = 6,375 was collated during July 2010 – June 2011. Results The results showed that television-lead mass-media significantly increased unprompted awareness (0% to 31.8%, p  Conclusions GHS mass-communications campaigns are effective at increasing awareness and usage of the GHS, especially among hard-to-reach population groups. Television advertising provides universal reach, but should be supplemented by health professional referrals and targeted mail-out information to recruit participants to the intensive GHS coaching program.

  16. Quantitative Review Finds No Evidence of Cognitive Effects in Healthy Populations From Single-session Transcranial Direct Current Stimulation (tDCS).

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    Horvath, Jared Cooney; Forte, Jason D; Carter, Olivia

    2015-01-01

    Over the last 15-years, transcranial direct current stimulation (tDCS), a relatively novel form of neuromodulation, has seen a surge of popularity in both clinical and academic settings. Despite numerous claims suggesting that a single session of tDCS can modulate cognition in healthy adult populations (especially working memory and language production), the paradigms utilized and results reported in the literature are extremely variable. To address this, we conduct the largest quantitative review of the cognitive data to date. Single-session tDCS data in healthy adults (18-50) from every cognitive outcome measure reported by at least two different research groups in the literature was collected. Outcome measures were divided into 4 broad categories: executive function, language, memory, and miscellaneous. To account for the paradigmatic variability in the literature, we undertook a three-tier analysis system; each with less-stringent inclusion criteria than the prior. Standard mean difference values with 95% CIs were generated for included studies and pooled for each analysis. Of the 59 analyses conducted, tDCS was found to not have a significant effect on any - regardless of inclusion laxity. This includes no effect on any working memory outcome or language production task. Our quantitative review does not support the idea that tDCS generates a reliable effect on cognition in healthy adults. Reasons for and limitations of this finding are discussed. This work raises important questions regarding the efficacy of tDCS, state-dependency effects, and future directions for this tool in cognitive research. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. Russian Contract Law for Foreigners

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    Andrey Shirvindt

    2015-01-01

    Full Text Available The book by Maria Efremova, Svetlana Yakovleva and Jane Henderson aims to serve as a short introduction to Russian contract law for a foreign lawyer. Assuming that the target readership are mainly English lawyers the book’s second aim, expressly stated by the authors (pp. i, 1, is to make lawyers from common law countries familiar with codified law, with Russian law being just an example. The book covers most of the general law of obligations as well as some questions of formation and invalidity of contracts that belong to the general part of the Civil Сode, with this preceded by a brief introduction into the Russian law dealing with its history, federal structure and state agencies of Russia, its court system, sources of law and legal profession.

  18. Bell Discourse in Russian Culture

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    Элеонора Р Лассан

    2014-12-01

    Full Text Available The article focuses on the symbolic meaning of Russian ringing of bell in the Russian discourse. According to Lotman’s definition of symbol, it has dual nature: an invariant essence and its modification in relation to the cultural context. The article introduces informative and linguistic modifications of the bell topic in the Russian poetic discourse of the 19th, the 20th and the beginning of the 21st century. The author of the article provides the detailed analysis of such discursive descriptions of bell ringing as the ringing of church bells and alarm . The author arrives at the conlusion that the alarm topic prevails in contemporary poetry and this indicates the state of public dissatisfaction. In the 19th and the 20th centuries lexemes the ringing of church bells and alarm were used literally, but in the 21st century lexeme alarm acquires metaphorical meaning of call for blood.

  19. A Cross-sectional Survey Assessing Carriage of Streptococcus pneumoniae in a Healthy Population in Xinjiang Uygur Autonomous Region of China.

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    Xie, Na; Chen, Zhao Yun; Chen, Tao; Zhu, Bing Qing; Xu, Li; Gao, Yuan; Zhang, Ai Yu; Zhao, Pan; Liu, Ji Wen; Shao, Zhu Jun

    2018-03-01

    The carriage rate and serotype distribution of Streptococcus pneumoniae (S. pneumoniae) in a healthy population in China remains unclear. In this study, we collected the oropharyngeal swabs from 513 individuals in Xinjiang, China. Real-time PCR targeting the lytA gene and 12 serotypes were assessed to identify S. pneumoniae carriage. The total carriage rate of S. pneumoniae was 70.4% (361/513). The most prevalent serotypes were 19B/F, 18B/C, 5, and 6A/B. The highest carriage rate of S. pneumoniae was noted in children aged 6-10 years (88.6%), which merits further attention. The co-colonization rate of two or more S. pneumoniae serotypes was 79.8% (264/331). This study aimed to investigate the baseline pneumococcal carriage rate among healthy individuals in China to improve our understanding of the epidemiology of S. pneumoniae. Copyright © 2018 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

  20. A Population-based Prospective Birth Cohort Study of Childhood Neurocognitive and Psychological Functioning in Healthy Survivors of Early-life Meningitis

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    Khandaker, Golam M.; Stochl, Jan; Zammit, Stanley; Lewis, Glyn; Jones, Peter B.

    2015-01-01

    PURPOSE To determine neurocognitive, educational and psychological functioning during childhood and early-adolescence among survivors of early-life meningitis who are apparently healthy. METHODS In the general population-based Avon Longitudinal Study of Parents and Children birth cohort, meningitis exposure was determined at age 18 months. The outcomes of IQ, short-term memory, working memory, reading and spelling abilities, psychological and behavioural problems, depressive and anxiety symptoms, and psychotic experiences at ages 9 to 13 years were compared between those exposed and unexposed to meningitis. Individuals with special educational needs were excluded. RESULTS By age 18 months, 67 out of 11,035 children were reported to have suffered from meningitis (0.61%). These children, compared with the unexposed, performed worse on all neurocognitive and educational measures; mean difference in total IQ 7.36 (95% CI 1.60-13.11). Meningitis was associated with higher depressive and anxiety symptoms (p=0.02), psychological and behavioural problems (p=0.09), and increased risk of psychotic experiences; risk ratio 2.22 (95% CI 1.12-4.38). CONCLUSIONS Exposure to meningitis in the early-life is associated with neurocognitive, educational and psychological difficulties during childhood and early-adolescence among survivors who are apparently healthy. Therefore, focusing only on serious neurologic disabilities may underestimate the true impact of early-life meningitis. PMID:25794764

  1. A population-based prospective birth cohort study of childhood neurocognitive and psychological functioning in healthy survivors of early life meningitis.

    Science.gov (United States)

    Khandaker, Golam M; Stochl, Jan; Zammit, Stanley; Lewis, Glyn; Jones, Peter B

    2015-04-01

    To determine neurocognitive, educational, and psychological functioning during childhood and early adolescence among survivors of early life meningitis who are apparently healthy. In the general population-based Avon Longitudinal Study of Parents and Children birth cohort, meningitis exposure was determined at age of 18 months. The outcomes of intelligence quotient, short-term memory, working memory, reading and spelling abilities, psychological and behavioral problems, depressive and anxiety symptoms, and psychotic experiences at ages 9 to 13 years were compared between those exposed and unexposed to meningitis. Individuals with special educational needs were excluded. By age of 18 months, 67 of 11,035 children were reported to have suffered from meningitis (0.61%). These children, compared with the unexposed, performed worse on all neurocognitive and educational measures; mean difference in total intelligence quotient 7.36 (95% confidence interval, 1.60-13.11). Meningitis was associated with higher depressive and anxiety symptoms (P = .02), psychological and behavioral problems (P = .09), and increased risk of psychotic experiences; risk ratio 2.22 (95% confidence interval, 1.12-4.38). Exposure to meningitis in the early life is associated with neurocognitive, educational, and psychological difficulties during childhood and early adolescence among survivors who are apparently healthy. Therefore, focusing only on serious neurologic disabilities may underestimate the true impact of early life meningitis. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. EEG-neurofeedback training of beta band (12-22Hz) affects alpha and beta frequencies - A controlled study of a healthy population.

    Science.gov (United States)

    Jurewicz, Katarzyna; Paluch, Katarzyna; Kublik, Ewa; Rogala, Jacek; Mikicin, Mirosław; Wróbel, Andrzej

    2018-01-08

    The frequency-function relation of various EEG bands has inspired EEG-neurofeedback procedures intending to improve cognitive abilities in numerous clinical groups. In this study, we administered EEG-neurofeedback (EEG-NFB) to a healthy population to determine the efficacy of this procedure. We evaluated feedback manipulation in the beta band (12-22Hz), known to be involved in visual attention processing. Two groups of healthy adults were trained to either up- or down-regulate beta band activity, thus providing mutual control. Up-regulation training induced increases in beta and alpha band (8-12Hz) amplitudes during the first three sessions. Group-independent increases in the activity of both bands were observed in the later phase of training. EEG changes were not matched by measured behavioural indices of attention. Parallel changes in the two bands challenge the idea of frequency-specific EEG-NFB protocols and suggest their interdependence. Our study exposes the possibility (i) that the alpha band is more prone to manipulation, and (ii) that changes in the bands' amplitudes are independent from specified training. We therefore encourage a more comprehensive approach to EEG-neurofeedback training embracing physiological and/or operational relations among various EEG bands. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Quantification of human polyomavirus JC virus load in urine and blood samples of healthy tribal populations of North-Eastern part of West Bengal, India.

    Science.gov (United States)

    Chattaraj, S; Bera, N K; Dutta, C; Bhattacharjee, S

    2015-01-01

    Human polyomavirus JC (JCV) is a widespread human virus with profound pathogenic potential. A study was undertaken to quantify JCV load in urine and peripheral blood samples of immunocompetent, apparently healthy tribal individuals of North-Eastern part of West Bengal, India for the first time. One hundred and thirteen samples of urine or blood were collected from different tribal groups of this region. For the quantitative estimation of the viral load in each sample, real-time polymerase chain reaction method using the SYBR Green dye was employed. The viral load estimated was found in the range between 3.5 × 102 and 2.12 × 106 copies/ml of samples having a mean and median viral copy numbers of 8.67 × 105 and 9.19 × 105 copies/ml of sample respectively. The mean viral DNA load in urine samples of the studied immunocompetent population was found to be higher than that found in a study conducted in the USA, but lower than similar groups of Italy and healthy adult women in the USA. However when compared with median values of viral DNA loads in urine samples of immunocompetent human subjects of Kuwait, Portugal, and Switzerland the observed viral DNA load was found to be substantially higher.

  4. LIFE EXPECTANCY AND THE HEALTHY LIFE OF A POPULATION – A CONSONANT VECTOR OF ECONOMIC PERFORMANCE, PUBLIC HEALTH SYSTEM AND MORAL VALUES

    Directory of Open Access Journals (Sweden)

    Mihai Luchian

    2015-03-01

    Full Text Available The performance of the therapeutical act depends on the personal training and optimum interdisciplinary cooperation of the medical staff involved, representing dynamic elements directly supported by adequate logistic means –medical technique and implements, drugs, procedures, etc. Considered from a dialectic perspective, all such factors of force are made up and are mainly and conjunctly manifested at the level of an elevated (ethic-moral and juridical deontological and normative level. The cooperative vectors of interest may be protected and increased by means of some key factors characteristic to the system of public health assurance, implicitly of the functional medical structures, for attaining the major goal of consolidating general health condition, alongwith the strategic factors for promoting a healthy, really economically and socially performant life of the population to come.

  5. Characterisation of Population Pharmacokinetics and Endogenous Follicle Stimulating Hormone (FSH) Levels after Multiple Dosing of a Recombinant Human FSH, FE 999049, in Healthy Women

    DEFF Research Database (Denmark)

    Rose, Trine Høyer; Röshammer, Daniel; Erichsen, Lars

    2016-01-01

    : Longitudinal measurements of FSH, luteinising hormone, progesterone, estradiol, and inhibin B levels were collected after repeated subcutaneous dosing with 225 IU of FE 999049 in 24 gonadotropin downregulated healthy women. The FSH data were described using nonlinear mixed-effects modelling. Results...... increased with body weight in accordance with an allometrically scaled power exponent of 0.75 and 1, respectively. Endogenous FSH levels were lower in individuals with higher progesterone levels at baseline and were further suppressed over time with increasing inhibin B levels. Conclusions......: This characterisation of FE 999049 population pharmacokinetics after repeated dosing is in line with previous findings after single-dose administration. The results provide a basis for study design and data evaluation in the future development of recombinant FSH products, and show it can be of importance to account...

  6. RUSSIAN DRINKING: TOO LATE FOR EMERGENCY MEASURES

    Directory of Open Access Journals (Sweden)

    Alexander Evgenjevich Kuznetsov

    2015-01-01

    Full Text Available Russian drinking for the first time demonstrates weakening of specialization in spirits drinking and stabilization of amount drunk. This suggests expectations of drinking qualitative turn, i.e. to consumer’s choice oriented to quality of drinking rather than to quantity, and further to lessening the drinking norm. Experience of wine-drinking countries of Europe and influence of pan-European homogenization of patterns of drinking, favor such a perspective. The marked decrease of drinking norm in wine-drinking countries was achieved with the minimal state intervention. Survey data (n=904 is provided to corroborate the claim that Russian drinking is able to self-regulate. The data witness weak support for government’s measures taken to restrict access to beverages sale in terms of age, time, place, and price; customers are likely to value freedom of choice unbridled. Governmental pursuance of simplistic access-and-pricing restrictive policies recently undertaken, may force Russian drinking back to another cycle of alcoholisation within the old ‘northern’ model. Bootlegging expansion, formerly progressive specialization in spirits drinking, habit of making gross purchases in population are explained by former experiences of coping with deficits, dry campaigns, and traditional culture of religious and secular abstinences. Scarcity of modes of compensatory behaviors and low concern for health also back up the special cultural status of alcohol. Government should seek for positive measures, viz. wider sporting involvement for students and inclusion for disabled to revive the nation’s regard for health and awareness of health-related risks.

  7. OVERVIEW OF RUSSIAN CIVIL JUSTICE

    Directory of Open Access Journals (Sweden)

    D. Maleshin

    2016-01-01

    Full Text Available Contemporary Russian civil procedure is not a pure Continental model because it also has procedural features of the common law system, as well as some other original and exceptional features. This article examines the main aspects of Russian civil justice: its main principles; judicial organization, including the structure of the courts and the division between courts of general jurisdiction and arbitrazh (commercial courts, and the Intellectual Property Court; sources of procedural law; bar organization; the jurisdiction of the courts; actions and proceedings; legal costs; evidence; administrative procedure; class actions; enforcement proceedings; and arbitration and mediation.

  8. Cardiovascular Risk and Serum Hyaluronic Acid: A Preliminary Study in a Healthy Population of Low/Intermediate Risk.

    Science.gov (United States)

    Papanastasopoulou, Chrysanthi; Papastamataki, Maria; Karampatsis, Petros; Anagnostopoulou, Eleni; Papassotiriou, Ioannis; Sitaras, Nikolaos

    2017-01-01

    Hyaluronic acid (HA) has been found to be an important trigger of atherosclerosis. In this study, we investigate the possible association of serum HA with cardiovascular disease risk in a population of low/intermediate risk for cardiovascular events. We enrolled 200 subjects with low/intermediate risk for developing cardiovascular disease. High specific C-reactive protein (hsCRP) was used as an indicator of preclinical atherosclerosis. The Framingham score was used to calculate the cardiovascular risk. Participants with dyslipidemia had significantly higher levels of serum HA than those without dyslipidemia (t-test, P = 0.05), higher levels of hsCRP (Kruskal-Wallis test, P = 0.04), and higher cardiovascular risk according to the Framingham score (Kruskal-Wallis test, P = 0.05). Serum HA concentration correlated significantly with the Framingham score for risk for coronary heart disease over the next 10 years (Spearman r = 0.152, P = 0.02). Diabetic volunteers had significantly higher HA than those without diabetes (t-test, P = 0.02). Participants with metabolic syndrome had higher serum HA levels and higher hsCRP (Kruskal-Wallis test, P = 0.01) compared to volunteers without metabolic syndrome (t-test, P = 0.03). Serum HA should be explored as an early marker of atheromatosis and cardiovascular risk. © 2016 Wiley Periodicals, Inc.

  9. Labor-Force Participation, Policies & Practices in an Aging America: Adaptation Essential for a Healthy & Resilient Population.

    Science.gov (United States)

    Berkman, Lisa F; Börsch-Supan, Axel; Avendano, Mauricio

    2015-01-01

    Population aging in the United States poses challenges to societal institutions while simultaneously creating opportunities to build a more resilient, successful, and cohesive society. Work organization and labor-force participation are central to both the opportunities and challenges posed by our aging society. We argue that expectations about old age have not sufficiently adapted to the reality of aging today. Our institutions need more adaptation in order to successfully face the consequences of demographic change. Although this adaptation needs to focus especially on work patterns among the "younger elderly," our society has to change its general attitudes toward work organization and labor-force participation, which will have implications for education and health care. We also show that work's beneficial effects on well-being in older ages are often neglected, while the idea that older workers displace younger workers is a misconception emerging from the "lump of labor" fallacy. We conclude, therefore, that working at older ages can lead to better quality of life for older people and to a more productive and resilient society overall.

  10. Serum Proteome Changes in Healthy Subjects with Different Genotypes of NOS1AP in the Chinese Population

    Directory of Open Access Journals (Sweden)

    Feng Jiang

    2013-01-01

    Full Text Available Type 2 diabetes and its chronic complications have become a worldwide epidemic nowadays. However, its molecular mechanism is still unknown. We have previously identified a novel variant rs12742393 of NOS1AP for type 2 diabetes susceptibility in the Chinese population. In this study, we analyzed the total serum profiling among three genotypes of rs12742393 to discover potential crosstalk under the variant and the disease through proteomic analyses for the first time. We used OFFGEL peptide fractionation, LC-MS/MS analysis, and label-free quantification to profile the fasting human serum samples of the genotypes in rs12742393 (n=4, for CC, AC, and AA, resp.. Four proteins were identified, including apoA4, alpha1-ACT, HABP2, and keratin 10, with blood levels changed significantly between CC and AA homozygotes of rs12742393. Compared with AA group, the levels of apoA4 increased (P=0.000265, whereas the concentration of alpha1-ACT, HABP2, and keratin 10 decreased in CC group (P=0.011116, 0.021175, and 0.015661, resp.. Then we selected additional fasting serum samples for ELISA and western blot validation. However, no significant differences were identified by neither ELISA nor western blot (P>0.05. The protein profiling changes between the genotypes of rs12742393 indicated that this SNP might play a role in the development of type 2 diabetes.

  11. Russian Airpower in the Second Chechen War

    National Research Council Canada - National Science Library

    Evans, Robert

    2001-01-01

    .... In the earlier conflict, Russian Air Force operations concentrated on achieving control of the air, directly supporting Russian ground forces, and attacking rebels in the foothills and mountains of southern Chechnya...

  12. Eating Healthy

    Science.gov (United States)

    ... There is much we can do to promote healthy eating habits. Together we can prevent or delay onset of diabetes, obesity and other chronic conditions and diseases. Benefits Helps maintain a healthy weight A healthy weight reduces risk of chronic ...

  13. Population-based estimation of renal function in healthy young Indian adults based on body mass index and sex correlating renal volume, serum creatinine, and cystatin C

    Directory of Open Access Journals (Sweden)

    Rajagopalan P

    2016-09-01

    Full Text Available Prashanth Rajagopalan,1 Georgi Abraham,2 Yuvaram NV Reddy,2 Ravivarman Lakshmanasami,1 ML Prakash,1 Yogesh NV Reddy2 1Department of General Medicine, Mahatma Gandhi Medical College and Research Institute, Puducherry, 2Department of Nephrology, Madras Medical Mission Hospital, Chennai, India Abstract: This population-based prospective study was undertaken in Mahatma Gandhi Medical College to estimate the renal function in young healthy Indian adults. A young healthy heterogeneous Indian cohort comprising 978 individuals, predominantly medical students, was assessed by a detailed questionnaire, and variables such as height, weight, body mass index (BMI, birth weight, and blood pressure were documented. Laboratory investigations included serum creatinine, serum cystatin C, blood sugar, urine protein, and imaging of the kidneys with ultrasound. The mean age of the cohort was 25±6 years, comprising 672 males and 306 females. The estimated glomerular filtration rates (eGFRs by the Cockcroft–Gault formula for BMI <18.5 kg/m2, 18.5–24.99 kg/m2, 25–29.99 kg/m2, and ≥30 kg/m2 were 71.29±10.45 mL/min, 86.38±13.46 mL/min, 98.88±15.29 mL/min, and 109.13±21.57 mL/min, respectively; the eGFRs using cystatin C for the four groups of BMI were 84.53±18.14 mL/min, 84.01±40.11 mL/min, 79.18±13.46 mL/min, and 77.30±10.90 mL/min, respectively. This study attempts to establish a normal range of serum creatinine and cystatin C values for the Indian population and shows that in young healthy Indian adults, eGFR and kidney volume vary by BMI and sex. Keywords: eGFR, birth weight, renal volume

  14. [Scientific evidence about the role of yogurt and other fermented milks in the healthy diet for the Spanish population].

    Science.gov (United States)

    Moreno Aznar, Luis A; Cervera Ral, Pilar; Ortega Anta, Rosa M; Díaz Martín, Juan José; Baladia, Eduard; Basulto, Julio; Bel Serrat, Silvia; Iglesia Altaba, Iris; López-Sobaler, Ana M; Manera, María; Rodríguez Rodríguez, Elena; Santaliestra Pasías, Alba M; Babio, Nancy; Salas-Salvadó, Jordi

    2013-11-01

    Milk products contain proteins of high biologic value and digestibility; they also contain fat, carbohydrates, vitamins and minerals, specially calcium and phosphorus. Diversification of milk products consumption allows a high consumptiom of the above mentioned products, optimizing nutrient intake. In Spain, food consumption of milk products lower than the recommended amounts was observed in 20 to 40 % of the children and 30 to 45 % of the adults. Milk products represent 44 to 70 % of calcium intake in the Spanish population. Milk products consumption is positively associated with a high bone mineral density. More than 35 % of children and adults in Spain had calcium intakes below the national recommendations. Yogur contains less lactose than regular milk and fermenting milk bacteries express functioning lactase. Yogur intake is recommended to improve lactose digestion in individuals having lactose maldigestion. It seems reasonable to recommend yogur to improve calcium absorption, at least in post-menopausal women, and also for decreasing incidence and duration of infectious gastrointestinal disorders in children. Fermented milk products consumption, before, during and after medical eradication of Helicobacter Pylori, increases 5 to 10 % the effect of the specific drug therapy. Its consumption before, during and after antibiotic treatment, could also reduce the risk of diarrhea associated with the use of the above mentioned drugs. The Spanish Federation of Nutrition, Feeding and Dietetic Societies (FESNAD) recommend the following consumption of milk and milk products: Adults, 2-3 portions/day; school-age children, 2-3 portions/day; adolescents, 3-4 portions/day; pregnant and lactating women and during menopause, 3-4 portions/day; elderly, 2-4 portions/day. Considering yogur and fermented milk consumption show some advantages when compared with other milk products, we can recommend yogur within a daily and varied consumption of milk products. Copyright AULA MEDICA

  15. Association between exercise habits and subcortical gray matter volumes in healthy elderly people: A population-based study in Japan.

    Science.gov (United States)

    Yamamoto, Mikie; Wada-Isoe, Kenji; Yamashita, Fumio; Nakashita, Satoko; Kishi, Masafumi; Tanaka, Kenichiro; Yamawaki, Mika; Nakashima, Kenji

    2017-06-01

    The relationship between exercise and subcortical gray matter volume is not well understood in the elderly population, although reports indicate that exercise may prevent cortical gray matter atrophy. To elucidate this association in the elderly, we measured subcortical gray matter volume and correlated this with volumes to exercise habits in a community-based cohort study in Japan. Subjects without mild cognitive impairment or dementia (n = 280, 35% male, mean age 73.1 ± 5.9 years) were evaluated using the Mini-Mental State Examination (MMSE), an exercise habit questionnaire, and brain magnetic resonance imaging. Subcortical gray matter volume was compared between groups based on the presence/absence of exercise habits. The MMSE was re-administered 3 years after the baseline examination. Ninety-one subjects (32.5%) reported exercise habits (exercise group), and 189 subjects (67.5%) reported no exercise habits (non-exercise group). Volumetric analysis revealed that the volumes in the exercise group were greater in the left hippocampus (p = 0.042) and bilateral nucleus accumbens (left, p = 0.047; right, p = 0.007) compared to those of the non-exercise group. Among the 195 subjects who received a follow-up MMSE examination, the normalized intra-cranial volumes of the left nucleus accumbens (p = 0.004) and right amygdala (p = 0.014)showed significant association with a decline in the follow-up MMSE score. Subjects with exercise habits show larger subcortical gray matter volumes than subjects without exercise habits in community-dwelling elderly subjects in Japan. Specifically, the volume of the nucleus accumbens correlates with both exercise habits and cognitive preservation.

  16. Emergence of new Russian and foreign investors in the Russian oil and gas complex

    International Nuclear Information System (INIS)

    Arbatov, A.A.

    1996-01-01

    A critical analysis is presented of the factors influencing foreign investment in Russian oil and gas exploration and production. Greater stability in the Russian economy would help and unfortunately some elements of the Russian bureaucracy hinder quick decision making. Western investors could improve their position by concentrating on developments which are unlikely to be developed by Russian companies in the next decade. (author)

  17. THE ROLE OF THE RUSSIANS OF TAJIKISTAN IN TRANSFORMING TAJIK SOCIETY

    Directory of Open Access Journals (Sweden)

    L. Yu. Nikolaeva

    2015-01-01

    Full Text Available The Russian population of Tajikistan has traditionally played a prominent role in political, economic, cultural and scientifi c development of the country despite the fact that Russian diaspora has always lacked consolidation. However the collapse of the USSR was followed by increasing deprivation of the Russians insofar as they adapt slowly to a new political and socio-economic system of Tajikistan, feel discriminated, are classifi ed as “poor” and tend to migrate to Russia. According to the author, the problem of the Russians in Tajikistan is a part of a broader “Russian problem of the XXIth century” and stresses the necessity to develop a national policy strategy of Russia.

  18. A Bright Future for Russian Higher Education.

    Science.gov (United States)

    Kishkovsky, Sophia

    2000-01-01

    Russian higher education is reinventing itself, but in distinctly Russian ways. While universities embrace new technology, students are frustrated as new freedoms confront old educational methods (grueling entrance exams, rote learning, dictatorial professors, and minimal participation). Education is still basically Russian, though capitalism is…

  19. Characteristics of Russian Professionals’ Organizational Behavior

    Directory of Open Access Journals (Sweden)

    V V Khurtina

    2013-12-01

    Full Text Available The paper describes organizational behavior of Russian professionals at the individual and organizational levels. The characteristics of Russian professionals’ organizational behavior are examined on the basis of the Russian Longitudinal Monitoring Survey of HSE, depending on the qualification level and age.

  20. Russian Loanword Adaptation in Persian; Optimal Approach

    Science.gov (United States)

    Kambuziya, Aliye Kord Zafaranlu; Hashemi, Eftekhar Sadat

    2011-01-01

    In this paper we analyzed some of the phonological rules of Russian loanword adaptation in Persian, on the view of Optimal Theory (OT) (Prince & Smolensky, 1993/2004). It is the first study of phonological process on Russian loanwords adaptation in Persian. By gathering about 50 current Russian loanwords, we selected some of them to analyze. We…

  1. SUPPLY AND DEMAND ON THE RUSSIAN STOCK MARKET: A SOCIOECONOMIC ANALYSIS

    Directory of Open Access Journals (Sweden)

    Podgornyy Boris Borisovich

    2013-03-01

    Full Text Available The stock market in advanced economies allows people to participate in the economic development by investing their savings in equities of leading and emerging industries. It solves a number of economic and social problems. There is less than 1% of the population takes part in investing in shares and other securities In Russia. The structure of Russian commercial organizations, the supply and demand of the Russian stock market are analyzes in the paper. Also the results of original sociological research explains the meaning of the factors wich are limiting the population to investing in the stock market instruments. And there are some measures proposed for the further development of the Russian stock market. The results of the research have both theoretical and practical significance. That can be used in the development of national and regional activities aimed at the development of the Stock Market and attracting the Russian population to invest the Stock Market instruments.

  2. Russian Speech in Radio: Norm and Deviation

    Directory of Open Access Journals (Sweden)

    Igor V. Nefedov

    2017-06-01

    Full Text Available National radio, like television, is called upon to bring to the masses not only relevant information, but also a high culture of language. There were always serious demands to oral public speech from the point of view of the correctness and uniformity of the pronunciation. However, today the analysis of the language practice of broadcasting often indicates a discrepancy between the use of linguistic resources in existing literary norms. The author of the article from the end of December 2016 to early April 2017 listened and analyzed from the point of view of language correctness the majority of programs on the radio Komsomolskaya Pravda (KP. In general, recognizing the good speech qualification of the workers of this radio, as well as their «guests» (political scientists, lawyers, historians, etc., one can not but note the presence of a significant number of errors in their speech. The material presented in the article allows us to conclude that at present, broadcasting is losing its position in the field of speech culture. Neglect of the rules of the Russian language on the radio «Komsomolskaya Pravda» negatively affects the image of the Russian language, which is formed in the minds of listeners. The language of radio should strive to become a standard of cleanliness and high culture for the population, since it has the enormous power of mass impact and supports the unity of the cultural and linguistic space.

  3. Reflection in Russian Educational Psychology.

    Science.gov (United States)

    Nelissen, Jo M. C.; Tomic, Welko

    This paper discusses the cultural-historical school founded by Vygotsky, Luria, and Leontiev as the theoretical background of Russian educational psychologists who have been studying how children learn to reflect. Two approaches to reflection are examined within the cultural-historical tradition: first, reflection--like other higher psychological…

  4. Economic Factors of Russian Inequality

    Science.gov (United States)

    Bobkov, Vyacheslav N.; Vakhtina, Margarita A.; Simonova, Marina V.

    2016-01-01

    The relevance of the researched problem is connected with the high level of economic inequality in Russia. The article goal is to show that the current Russian institutional system is not directed to decrease the economic inequality but on the contrary it continues to make and deepen it. The leading approach to study of this problem is the…

  5. Gazprom the new russian empire

    International Nuclear Information System (INIS)

    Cosnard, D.

    2004-01-01

    The author analyzes the economical and political impacts of the great Gazprom group, leader in the russian energy domain, in Russia. Already number one of the world gas industry, this Group is becoming the right-hand of the Kremlin. Thus the author wonders on this empire transparency and limits. (A.L.B.)

  6. Russian nominal semantics and morphology

    DEFF Research Database (Denmark)

    Nørgård-Sørensen, Jens

    The principal idea behind this book is that lexis and grammar make up a single coherent structure. It is shown that the grammatical patterns of the different classes of Russian nominals are closely interconnected. They can be described as reflecting a limited set of semantic distinctions which ar...... or weaker, of Russian. Students will see a pattern in what is traditionally described as disparate subsystems, and linguists may be inspired to consider the theoretical points concerning language as a coherent system, determining usage.......The principal idea behind this book is that lexis and grammar make up a single coherent structure. It is shown that the grammatical patterns of the different classes of Russian nominals are closely interconnected. They can be described as reflecting a limited set of semantic distinctions which...... are also rooted in the lexical-semantic classification of Russian nouns. The presentation focuses on semantics, both lexical and grammatical, and not least the connection between these two levels of content. The principal theoretical impact is the insight that grammar and lexis should not be seen...

  7. Roots of Russian Irregular Warfare

    Science.gov (United States)

    2016-12-01

    PAGE INTENTIONALLY LEFT BLANK xiii ACKNOWLEDGMENTS Crissy, your encouragement throughout my career and especially during this project has been...all of the Russian disinformation techniques in Ukraine came directly “from Soviet toolkits .” Maria Snegovaya, “Putin’s Information Warfare In

  8. Management of Russian military plutonium

    International Nuclear Information System (INIS)

    Zaleski, C.P.

    1996-01-01

    The objective of this paper is to propose and discuss a solution which enables storing as quickly as possible all weapons-grade plutonium from Russian military program in a way which would prevent diversion. Two main conditions apply to this solution. First, it should be achieved in a manner acceptable to Russian government, notably by preserving plutonium for possible future energy production, and second, the economics of the total system should be good enough to ensure no charge or limited charge for the storage of plutonium. A proposal is made to store plutonium in a specially designed fast reactor or specially designed reactor core. This solution could be favorable in comparison to other solutions applying the above mentioned goal and conditions. Additionally the proposed solution would have the following side advantages: utilizing available personnel and installations of the Russian nuclear complex; providing possible basis for decommissioning of older and less safe Russian reactors; giving experience of construction and operation of a series of sodium-cooled fast reactors. The major problem however is the need for large capital investment with the risk of getting no adequate return on investment due to difficult political and economic situation in Russia

  9. REFLECTION IN RUSSIAN EDUCATIONAL PSYCHOLOGY

    NARCIS (Netherlands)

    Nelissen, J.M.C.; Tomic, W.

    2008-01-01

    The present article explores the theoretical underpinnings upon which Russian psychologists base their analysis of reflection. The intention is to arrive at a clearer understanding of their research aims and research methods, and to explore the relevance of their research to educational practice.

  10. Reforming the Russian electricity market

    International Nuclear Information System (INIS)

    Valladares, Mayra Rodriguez

    1999-08-01

    Contains Executive Summary and Chapters on: Overview; Russian energy markets; Evolution of the power sector; The electricity market; Regulation and proposed reforms; Politics in the power sector; Economics of the power sector; Regional differences; Foreign involvement; Valuation and company management; Conclusions. (Author)

  11. Russian Initiatives in Internet Governance

    Directory of Open Access Journals (Sweden)

    Sergey Sergeevich Shirin

    2014-01-01

    Full Text Available The article is devoted to the research of Russian initiatives concerning its participation in international system of Internet governance. In the research, conceptual and theoretic basis for participation of state governments in Internet governance is given, academic discourse of this issue is assessed, the review of main Russian initiatives made from 2005 (since the second stage of the World Summit on Information Society till the present day is carried out. The conclusion is made that the most successful Internet governance initiative of Russia is the implementation of cyrillic top level domains. Much less successful are Russian attempts to reconstruct existing organizational structure of Internet governance. Russian policy is assessed as a policy of preferring loud statements and PR rather than real influence on development of Internet technologies. Russia consideres Internet as political resource and tries to increase its influence on decision making process on a political, not operational level of Internet governance. The author states that federal government of the United States of America has fully lost the control on the domain name systems. These functions are going to be given to the private sector, while ICANN, which was established according to the Memorandum of Understanding/Joint Project Agreement with U.S. Department of Commerce, is becoming a truly independent international organization. Considering this, the author comes to the conclusion that political transformations for the sake of Russia are already made. He also forecast that next initiatives of Russia will be directed to the segmentation of the Internet.

  12. Polymorphisms associated with the risk of lung cancer in a healthy Mexican Mestizo population: application of the additive model for cancer

    Directory of Open Access Journals (Sweden)

    Rebeca Pérez-Morales

    2011-01-01

    Full Text Available Lung cancer is the leading cause of cancer mortality in Mexico and worldwide. In the past decade, there has been an increase in the number of lung cancer cases in young people, which suggests an important role for genetic background in the etiology of this disease. In this study, we genetically characterized 16 polymorphisms in 12 low penetrance genes (AhR, CYP1A1, CYP2E1, EPHX1, GSTM1, GSTT1, GSTPI, XRCC1, ERCC2, MGMT, CCND1 and TP53 in 382 healthy Mexican Mestizos as the first step in elucidating the genetic structure of this population and identifying high risk individuals. All of the genotypes analyzed were in Hardy-Weinberg equilibrium, but different degrees of linkage were observed for polymorphisms in the CYP1A1 and EPHX1 genes. The genetic variability of this population was distributed in six clusters that were defined based on their genetic characteristics. The use of a polygenic model to assess the additive effect of low penetrance risk alleles identified combinations of risk genotypes that could be useful in predicting a predisposition to lung cancer. Estimation of the level of genetic susceptibility showed that the individual calculated risk value (iCRV ranged from 1 to 16, with a higher iCRV indicating a greater genetic susceptibility to lung cancer.

  13. Russian Chronicles on the Submission of the Kievan Rus’ to the Mongol Empire

    Directory of Open Access Journals (Sweden)

    Roman Hautala

    2013-09-01

    Full Text Available In this paper I would like to present fragments of the Russian chronicles from the 13th and 14th centuries dedicated to the period of submission of Rus’ to the Mongols in 1237–1260. The process of submission of Russia to the Golden Horde is divided into two periods. The first one (1237–40 regards properly the Mongol invasion of Russian territories. The second period (1240–60 concerns the gradual submission of Russia to the Golden Horde, the process which had a more peaceful nature. The Mongol invasion was the defining moment for Kievan Rus’: for the first time in its history, the Russian population underwent a full-scale extermination with the destruction of chief towns. Contemporary to the invasion, Russian chronicles describe warfare at length and show emotional involvement as well. The requirement of the Mongol governors of absolute submission to their power with payment of the tenth share from all types of income and property are perceived as absolutely inadmissible. The succeeding destruction of the main towns of Russia, the last centres of resistance, is perceived in chronicles as a divine punishment for lack of military cooperation between the Russian princes. The Mongols themselves are presented as tabsolutely alien to orthodox culture and their pagan customs cause disgust in the authors of Russian chronicles. The subsequent period of the gradual submission of Russia to the Golden Horde is not less important in the evolution of political and cultural relations between nomads and the Russian settled population. Russian chronicles testify to fast restoration of towns after the Mongol invasion and stabilization of economic life. The governors of the Golden Horde are limited by the requirement of formal submission of the Russian princes which avoided direct military showdowns. Russia gradually became involved in the fiscal system of the Mongolian empire, but in exchange Russian princes receive a considerable political autonomy.

  14. EDWARD SUESS AND RUSSIAN GEOLOGISTS

    Directory of Open Access Journals (Sweden)

    Boris A. Natal’in

    2011-01-01

    Full Text Available The publication is devoted to the history of one of the greatest concepts of tectonics of Asia, that has been widely accepted and yet obliterated with time, while the splendors of this concept are doubtful. Numerous citations in the Russian papers to «The Face of the Earth» by Edward Suess and the fact that he was elected a Corresponding Member of the Imperial Saint Petersburg Academy of Sciences clearly demonstrate how highly Suess’s contribution to studies of the structure and geological evolution of Asia was valued by the Russian geological community. Suess’s letters to Vladimir A. Obruchev give evidence how close and productive the relationship between Edward Suess and the Russian researchers was in the late 19th and the early 20th centuries and also illustrate how the great tectonic concept of Asia [Suess, 1908] was born and developed. The idea of centrifugal propagation of tectonic waves of the Altaids from a continental node located somewhere in Siberia was mainly inspired by Suess’s profound scientific intuition. The idea matured after Edward Suess got acquainted with Ivan D. Chersky’s paper [Черский, 1886] that greatly facilitated in shaping and improving this idea. It was mailed to Suess by Vladimir A. Obruchev who translated the paper, attached his own map and provided explanations to Chersky’s ideas. The available historical documents suggest that Vladimir A. Obruchev facilitated communication between the Russian geologists, on the one side, and Edward Suess and other Austrian geologists who conducted geological studies in Asia, on the other side. Being actively involved in exchange of publications and cooperation in field data processing, Edward Suess was aware of all the details of the Russian geological studies.In addition to the concept of tectonic arcs of the Altaids and descriptions of main geological structures located in Northern Asia and China, Edward Suess adopted a concept of disjunctive dislocations

  15. Assessment of knowledge about healthy heart habits in urban and rural population of Punjab after SMS campaign-A cross-sectional study.

    Science.gov (United States)

    Mohan, Bishav; Sharma, Sarit; Sharma, Shruti; Kaushal, Dinesh; Singh, Bhupinder; Takkar, Shibba; Aslam, Naved; Goyal, Abhishek; Wander, Gurpreet S

    The prevalence of cardiovascular diseases (CVD) is increasing in developing countries but the awareness regarding prevention and treatment of these diseases is still low. Therefore the present study was conducted with the aim of imparting health education regarding certain changes in lifestyle and dietary habits among general population through the use of short message service (SMS) that may lead to improved knowledge about prevention of cardiovascular diseases. This cross-sectional study was conducted over a period of seven months. In the first phase, health education messages were sent through SMS to about 40,000 individuals from urban and rural population in Punjab. Twenty eight messages were sent to each individual and hence more than eleven lakh messages were sent over a period of six months. A questionnaire containing 11 questions based on these health education SMS was generated. Every 40th individual enrolled in the study was contacted on phone, and their responses noted. The data so collected was analyzed for correct responses. Complete responses could be obtained from 800 participants (males: 561 and females: 239). The participants giving correct responses to different questions ranged from 43% to 94%. Majority of participants could retain knowledge about many aspects of healthy heart habits provided by SMS except for topics concerning foods to be avoided, target for normal BP and precautions to be taken before BP measurement. Health related information imparted through SMS can act as a very effective tool for disseminating knowledge about prevention of heart diseases in general population. Copyright © 2017 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

  16. Russian perspectives: The past shapes the present

    Energy Technology Data Exchange (ETDEWEB)

    Houck, R.P.

    1994-11-01

    This document contains an outline of a speech given to a group of professionals at Pacific Northwest Laboratory which was intended to give an unbiased view of Soviet perceptions. Topics discussed include: The new mission of US and Soviet labs and institutions to develop products and dedicate research to post cold war threat, historical prospectives of Russia, Russian military roles and missions, ideology of Russian politics, evils of capitalism, Russian civil war, communism, world war II, Russian losses during the war, the cold war, reasons why America should care what happens in Russia, the internal threat against a market-based economy, the US should help, and the Russian people and their attitudes.

  17. Association between lumbar bone mineral density and serum uric acid in postmenopausal women: a cross-sectional study of healthy Chinese population.

    Science.gov (United States)

    Han, Wen; Bai, Xiaojuan; Wang, Nan; Han, Lulu; Sun, Xuefeng; Chen, Xiangmei

    2017-12-01

    Partial correlation and regression analyses were used in this study. We showed that there is a linear relationship between bone mineral density and serum uric acid within the normal physiologic range, and higher serum uric acid levels had a protective effect on bone loss in postmenopausal osteoporosis. The significance of the relationship between lumbar bone mineral density ( BMD) and serum uric acid (SUA) levels is unclear. The aims of this study were to investigate on a population-level the association between lumbar BMD and SUA within the normal physiologic range and to determine whether SUA plays a protective role in bone loss in healthy postmenopausal Chinese women. This was a community-based cross-sectional study involving 390 healthy postmenopausal women, 47-89 years of age, conducted in Shenyang, China. The BMD was measured at the lumbar spine using dual-energy X-ray absorptiometry (DXA). The SUA levels were obtained at each DXA visit. Partial correlation and regression analyses were applied to determine the associations. The SUA levels were significantly different between the normal BMD, osteopenia, and osteoporosis groups. The lumbar BMD was positively correlated with SUA in postmenopausal women after adjustment for age (r = 0.212). After adjustment for age, body mass index, systolic blood pressure, diastolic blood pressure, hip circumference, cigarette smoking, alcohol consumption, milk intake, physical exercise, fracture history, total protein, total bilirubin, triglycerides, total cholesterol, high-density lipoprotein cholesterol, fasting blood glucose, serum calcium, and estimated glomerular filtration rate, the lumbar BMD was associated with SUA and the odds ratio of the third SUA quartile was 0.408 (95%CI, 0.198-0.841, P = 0.015), compared to the first quartile of SUA levels. The lumbar BMD was linearly associated with SUA levels within the normal physiologic range of postmenopausal women. Higher SUA levels had a protective effect on bone loss

  18. Polish-Bulgarian-Russian, Bulgarian-Polish-Russian or Russian-Bulgarian-Polish dictionary?

    Directory of Open Access Journals (Sweden)

    Violetta Koseska-Toszewa

    2015-11-01

    Full Text Available Polish-Bulgarian-Russian, Bulgarian-Polish-Russian or Russian-Bulgarian-Polish dictionary? The trilingual dictionary (M. Duszkin, V. Koseska, J. Satoła and A. Tzoneva is being elaborated based on a working Polish-Bulgarian-Russian electronic parallel corpus authored by Maksim Duszkin, Violetta Koseska-Toszewa and Joanna Satoła-Staśkowiak, and works by A. Tzoneva. It is the first corpus comparing languages belonging to three different Slavic language groups: western, southern and eastern. Works on the dictionary are based on Gramatyka konfrontatywna bułgarsko-polska (Bulgarian-Polish confrontative grammar and the proposed there semantic-oriented interlanguage. Two types of classifiers have been introduced into the dictionary: classic and semantic. The trilingual dictionary will present a consistent and homogeneous set of facts of grammar and semantics. The Authors point out that in a traditional dictionary it is not clear for example whether aspect should be understood as imperfective / perfective form of a verb or as its meaning. Therefore in the dictionary forms and meaning are separated in a regular way. Imperfective verb form has two meanings: state and configuration of states and events culminating in state. Also perfective verb form has two meanings: event and configuration of states and events culminating in event. These meanings are described by the semantic classifiers, respectively, state and event, state1 and event1. The way of describing language units, mentioned in the article, gives a possibility to present language material (Polish, Bulgarian, Russian in any required order, hence the article’s title.

  19. The normal limits, subclinical significance, related metabolic derangements and distinct biological effects of body site-specific adiposity in relatively healthy population.

    Directory of Open Access Journals (Sweden)

    Chun-Ho Yun

    Full Text Available BACKGROUND: The accumulation of visceral adipose tissue that occurs with normal aging is associated with increased cardiovascular risks. However, the clinical significance, biological effects, and related cardiometabolic derangements of body-site specific adiposity in a relatively healthy population have not been well characterized. MATERIALS AND METHODS: In this cross-sectional study, we consecutively enrolled 608 asymptomatic subjects (mean age: 47.3 years, 27% female from 2050 subjects undergoing an annual health survey in Taiwan. We measured pericardial (PCF and thoracic peri-aortic (TAT adipose tissue volumes by 16-slice multi-detector computed tomography (MDCT (Aquarius 3D Workstation, TeraRecon, San Mateo, CA, USA and related these to clinical characteristics, body fat composition (Tanita 305 Corporation, Tokyo, Japan, coronary calcium score (CCS, serum insulin, high-sensitivity C-reactive protein (Hs-CRP level and circulating leukocytes count. Metabolic risk was scored by Adult Treatment Panel III guidelines. RESULTS: TAT, PCF, and total body fat composition all increased with aging and higher metabolic scores (all p<0.05. Only TAT, however, was associated with higher circulating leukocyte counts (ß-coef.:0.24, p<0.05, serum insulin (ß-coef.:0.17, p<0.05 and high sensitivity C-reactive protein (ß-coef.:0.24, p<0.05. These relationships persisted after adjustment in multivariable models (all p<0.05. A TAT volume of 8.29 ml yielded the largest area under the receiver operating characteristic curve (AUROC: 0.79, 95%CI: 0.74-0.83 to identify metabolic syndrome. TAT but not PCF correlated with higher coronary calcium score after adjustment for clinical variables (all p<0.05. CONCLUSION: In our study, we observe that age-related body-site specific accumulation of adipose tissue may have distinct biological effects. Compared to other adiposity measures, peri-aortic adiposity is more tightly associated with cardiometabolic risk profiles and

  20. Under-reported income of Russian households

    Directory of Open Access Journals (Sweden)

    Yaroslav Murashov

    2016-03-01

    Full Text Available In the proposed paper, an attempt is made to estimate the proportion of unstated income for Russian households based on micro data. An overview of microeconomic approaches to estimating the scale of under-reported income is provided. These approaches are weakly represented in the national literature, so their strengths and weaknesses are also analyzed. A theoretical model of household consumer behavior is described that allows the size of under-reported income to be estimated. The structure of household incomes and expenditures is studied based on an RLMS sample for 2012. The model is estimated using household subsamples based on the type of household and household income. The estimation technique utilizes regression variables and random effects. The resulting subsample estimates were applied to the general population and compared with those obtained by other researchers using alternative methods and other data. A comparison is made to estimates of under-reported income developed for British households.

  1. Audit of preventive activities in 16 inner London practices using a validated measure of patient population, the 'active patient' denominator. Healthy Eastenders Project.

    Science.gov (United States)

    Robson, J; Falshaw, M

    1995-01-01

    BACKGROUND. Reliable comparison of the results of audit between general practices and over time requires standard definitions of numerators and denominators. This is particularly relevant in areas of high population turnover and practice list inflation. Without simple validation to remove supernumeraries, population coverage and professional activity may be underestimated. AIM. This audit study aimed to define a standard denominator, the 'active patient' denominator, to enable comparison of professional activity and population coverage for preventive activities between general practices and over time. It also aimed to document the extent to which computers were used for recording such activities. METHOD. A random sample of people in the age group 30-64 years was drawn from the computerized general practice registers of the 16 inner London general practices that participated in the 'healthy eastenders project'. A validation procedure excluded those patients who were likely to have died or moved away, or who for administrative reasons were unable to contribute to the numerator; this allowed the creation of the active patient denominator. An audit of preventive activities with numerators drawn from both paper and computerized medical records was carried out and results were presented so that practices could compare their results with those of their peers and over time. RESULTS. Of the original sample of 2331 people, 25% (practice range 13%-37%) were excluded as a result of the validation procedure. A denominator based on the complete, unexpurgated practice register rather than the validated active patient denominator would have reduced the proportion of people with blood pressure recorded within the preceding five years from 77% to 61%, recording of smoking status from 68% to 53% and recording of cervical smears from 80% to 66%. Only 53% of the last recordings, within the preceding five years, of blood pressure and only 54% of those of smoking status were recorded on

  2. Nuclear knowledge management: Russian lessons

    International Nuclear Information System (INIS)

    Gagarinski, A.; Yakovlev, N.

    2004-01-01

    The paper describes the Soviet experience preserved in Russia and related to the strategy of nuclear knowledge preservation in period of fast nuclear energy deployment. It's also discusses the problems of 80-90ies: 'gap' between generations, loss of the experimental base, ageing of scientific teams, weakened governmental support, etc. Obviously resumed positive development of the Russian nuclear energy in the last years, as well as expectation of the 'Second Nuclear Era' of large-scale nuclear energy use in the country, has made the elimination of NKM defects and the development of human resources one of the most important and vital prerequisites of the further nuclear development. The paper considers the measures taken in this regard by the Russian nuclear industry, including international cooperation

  3. A randomized trial of fish oil omega-3 fatty acids on arterial health, inflammation, and metabolic syndrome in a young healthy population

    Science.gov (United States)

    2013-01-01

    Background Long chain omega-3 fatty acids from fish oils (O3) are known to have beneficial effects on a number of vascular risk factors in at-risk populations. The effects of a highly bioavailable emulsified preparation on an overweight young adult population are less well known. Methods Young adults, age 18–30, with body mass indices (BMIs) greater than 23 (average = 28.1) were administered 1.7 g of O3 per day (N = 30) or safflower oil placebo (N = 27) in an emulsified preparation (Coromega, Inc.) for 4 weeks in a double-blind randomized design. Blood was drawn and anthropometric measurements taken before and after dosing. Hemodynamic measures (central pulse wave velocity, augmentation index, and aortic systolic blood pressure), inflammatory cytokines (IL-6, IL-8, IL-10, and tumor necrosis factor-α), red blood cell and plasma phospholipid fatty acid profiles, fasting serum lipids, glucose, and C-reactive protein were measured. Results Red cell and plasma phospholipid eicosapentaenoic acid and docosahexaenoic acid concentrations increased over the four weeks of dosing in the O3 group. Dosing with O3 did not affect central pulse wave velocity, augmentation index, or aortic systolic blood pressure. None of the five American Heart Association metabolic syndrome components improved over the dosing period. None of the inflammatory cytokines, C-reactive protein, or lipids (total or LDL cholesterol) improved over the dosing period. Conclusions No salutary effects of O3 were observed in hemodynamic, metabolic syndrome criteria or inflammatory markers as a result of this relatively short period of administration in this relatively overweight, but healthy young adult cohort. PMID:23565815

  4. Subclinical cardiovascular disease assessment and its relationship with cardiovascular risk SCORE in a healthy adult population: A cross-sectional community-based study.

    Science.gov (United States)

    Mitu, Ovidiu; Roca, Mihai; Floria, Mariana; Petris, Antoniu Octavian; Graur, Mariana; Mitu, Florin

    The aim of this study is to evaluate the relationship and the accuracy of SCORE (Systematic Coronary Risk Evaluation Project) risk correlated to multiple methods for determining subclinical cardiovascular disease (CVD) in a healthy population. This cross-sectional study included 120 completely asymptomatic subjects, with an age range 35-75 years, and randomly selected from the general population. The individuals were evaluated clinically and biochemical, and the SCORE risk was computed. Subclinical atherosclerosis was assessed by various methods: carotid ultrasound for intima-media thickness (cIMT) and plaque detection; aortic pulse wave velocity (aPWV); echocardiography - left ventricular mass index (LVMI) and aortic atheromatosis (AA); ankle-brachial index (ABI). SCORE mean value was 2.95±2.71, with 76% of subjects having SCORE <5. Sixty-four percent of all subjects have had increased subclinical CVD changes, and SCORE risk score was correlated positively with all markers, except for ABI. In the multivariate analysis, increased cIMT and aPWV were significantly associated with high value of SCORE risk (OR 4.14, 95% CI: 1.42-12.15, p=0.009; respectively OR 1.41, 95% CI: 1.01-1.96, p=0.039). A positive linear relationship was observed between 3 territories of subclinical CVD (cIMT, LVMI, aPWV) and SCORE risk (p<0.0001). There was evidence of subclinical CVD in 60% of subjects with a SCORE value <5. As most subjects with a SCORE value <5 have subclinical CVD abnormalities, a more tailored subclinical CVD primary prevention program should be encouraged. Copyright © 2016 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.

  5. Heat transfer bibliography: russian works

    Energy Technology Data Exchange (ETDEWEB)

    Luikov, A V

    1965-02-01

    This bibliography of recent Russian publications in heat transfer is divided into the following categories: (1) books; (2) general; (3) experimental methods; (4) analytical calculation methods; (5) thermodynamics; (6) transfer processes involving phase conversions; ((7) transfer processes involving chemical conversions; (8) transfer processes involving very high velocities; (9) drying processes; (10) thermal properties of various materials, heat transfer agents and their determination methods; (11) high temperature physics and magneto- hydrodynamics; and (12) transfer processes in technological apparatuses. (357 refs.)

  6. Efficiency model of Russian banks

    OpenAIRE

    Pavlyuk, Dmitry

    2006-01-01

    The article deals with problems related to the stochastic frontier model of bank efficiency measurement. The model is used to study the efficiency of the banking sector of The Russian Federation. It is based on the stochastic approach both to the efficiency frontier location and to individual bank efficiency values. The model allows estimating bank efficiency values, finding relations with different macro- and microeconomic factors and testing some economic hypotheses.

  7. Corporate Corruption in Russian Regions

    OpenAIRE

    Ledeneva, A. V.

    2011-01-01

    To understand corporate corruption in Russia and to develop both effective anti-corruption policies at the macro level and anti-corruption strategies at the firm level one has to move beyond the predominant paradigm and to disaggregate its measurement. This article outlines the results of a pilot survey of CEOs of leading companies operating in the Russian regions with regard to their use of informal practices.

  8. Validation of a Russian Language Oswestry Disability Index Questionnaire.

    Science.gov (United States)

    Yu, Elizabeth M; Nosova, Emily V; Falkenstein, Yuri; Prasad, Priya; Leasure, Jeremi M; Kondrashov, Dimitriy G

    2016-11-01

    Study Design  Retrospective reliability and validity study. Objective  To validate a recently translated Russian language version of the Oswestry Disability Index (R-ODI) using standardized methods detailed from previous validations in other languages. Methods  We included all subjects who were seen in our spine surgery clinic, over the age of 18, and fluent in the Russian language. R-ODI was translated by six bilingual people and combined into a consensus version. R-ODI and visual analog scale (VAS) questionnaires for leg and back pain were distributed to subjects during both their initial and follow-up visits. Test validity, stability, and internal consistency were measured using standardized psychometric methods. Results Ninety-seven subjects participated in the study. No change in the meaning of the questions on R-ODI was noted with translation from English to Russian. There was a significant positive correlation between R-ODI and VAS scores for both the leg and back during both the initial and follow-up visits ( p  Russian-speaking population in the United States.

  9. 3 Tesla (1) H MR spectroscopy of hip bone marrow in a healthy population, assessment of normal fat content values and influence of age and sex.

    Science.gov (United States)

    Pansini, Vittorio; Monnet, Aurélien; Salleron, Julia; Hardouin, Pierre; Cortet, Bernard; Cotten, Anne

    2014-02-01

    To evaluate in a healthy population normal spectroscopic fat content (FC) values of the hip bone marrow and to assess the influence of age and sex on bone marrow conversion. Eighty volunteers (40 men; 40 women; ages: 20-60 years; divided into four consecutive groups) underwent acetabulum, femoral head, femoral neck, greater trochanter, and diaphysis localized (1) H MR spectroscopy. FC values of each anatomical site were obtained according to the following formula: Fat content = CH2 /(CH2  + Water)*100. To assess bone marrow conversion, a spectroscopic conversion index (SCI) was calculated as FC neck/FC greater trochanter. FC values showed a gradient as follows: greater trochanter > femoral head > femoral neck > diaphysis > acetabulum in every age group both in men and in women. SCI increased with age both in men and women, showing lower values in women for every age group. We obtained normal spectroscopic FC values from different areas of the hip, according to age and sex. These values may be used as reference values to evaluate, by the means of (1) H MR spectroscopy, pathological conditions affecting hip bone marrow. Copyright © 2013 Wiley Periodicals, Inc.

  10. Segregating polymorphisms of FOXP2 are associated with measures of inner speech, speech fluency and strength of handedness in a healthy population.

    Science.gov (United States)

    Crespi, Bernard; Read, Silven; Hurd, Peter

    2017-10-01

    We genotyped a healthy population for three haplotype-tagging FOXP2 SNPs, and tested for associations of these SNPs with strength of handedness and questionnaire-based metrics of inner speech characteristics (ISP) and speech fluency (FLU), as derived from the Schizotypal Personality Questionnaire-BR. Levels of mixed-handedness were positively correlated with ISP and FLU, supporting prior work on these two domains. Genotype for rs7799109, a SNP previously linked with lateralization of left frontal regions underlying language, was associated with degree of mixed handedness and with scores for ISP and FLU phenotypes. Genotype of rs1456031, which has previously been linked with auditory hallucinations, was also associated with ISP phenotypes. These results provide evidence that FOXP2 SNPs influence aspects of human inner speech and fluency that are related to lateralized phenotypes, and suggest that the evolution of human language, as mediated by the adaptive evolution of FOXP2, involved features of inner speech. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. A primary care based healthy-eating and active living education session for weight reduction in the pre-diabetic population.

    Science.gov (United States)

    Weir, Daniala L; Johnson, Steven T; Mundt, Clark; Bray, Dianne; Taylor, Lorian; Eurich, Dean T; Johnson, Jeffrey A

    2014-12-01

    Many studies have demonstrated the effectiveness of primary prevention strategies in type 2 diabetes, however, questions remain around the feasibility of high resource, intensive interventions within a healthcare setting. We report the results of a dietitian-led pre-diabetes education session targeting healthy eating and active living as strategies for weight reduction. Participants were asked to complete a baseline questionnaire prior to completing the pre-diabetes education session and were sent follow-up questionnaires at 3 and 6 months. Differences between participants at baseline, 3 and 6 months were determined using χ(2), t-tests and ANOVA. Of the 211 participants asked to fill out baseline questionnaires, 45 participants completed questionnaires at baseline, 3 months and 6 months. Although we observed general trends towards improvements in diet, physical activity and weight related behaviours among the 45 completers, no significant changes were observed among participants between questionnaire periods. A "one-off", theory-guided group education session may be insufficient to support lifestyle modifications in the context of weight management in a pre-diabetic population. Further evaluation of the efficacy and feasibility of the PCN as a setting for lifestyle intervention is required. Copyright © 2014 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

  12. Russian RBMK reactor design information

    International Nuclear Information System (INIS)

    1993-11-01

    This document concerns the systems, design, and operations of the graphite-moderated, boiling, water-cooled, channel-type (RBMK) reactors located in the former Soviet Union (FSU). The Russian Academy of Sciences Nuclear Safety Institute (NSI) in Moscow, Russia, researched specific technical questions that were formulated by the Pacific Northwest Laboratory (PNL) and provided detailed technical answers to those questions. The Russian response was prepared in English by NSI in a question-and-answer format. This report presents the results of that technical exchange in the context they were received from the NSI organization. Pacific Northwest Laboratory is generating this document to support the US Department of Energy (DOE) community in responding to requests from FSU states, which are seeking Western technological and financial assistance to improve the safety systems of the Russian-designed reactors. This report expands upon information that was previously available to the United States through bilateral information exchanges, international nuclear society meetings, International Atomic Energy Agency (IAEA) reactor safety programs, and Research and Development Institute of Power Engineering (RDIPE) reports. The response to the PNL questions have not been edited or reviewed for technical consistency or accuracy by PNL staff or other US organizations, but are provided for use by the DOE community in the form they were received

  13. Russian Capital in Latvia: Trends and Perspectives

    Directory of Open Access Journals (Sweden)

    N A Volgina

    2015-12-01

    Full Text Available The article deals the issue of the positions of Russian capital in Latvian market. The paper aims to estimate the volume and dynamics of Russian capital inflows into Latvia in compliance with Russian economic interests; to identify key sectors of Latvian economy that Russian capital is interested to invest in; to systemize information concerning Russian firms investing in Latvia; to assess the role of Russian capital in Latvian economy in comparison with other foreign investors; to propose author’s view on challenges and perspectives of Latvian-Russian investment cooperation in the situation of economic sanctions and geo-political conflict in east Ukraine. The author underlines that at the end of 2013, investments of Russian business to Latvia constituted about 5.0% of the total FDI stock and by that time Russia was the 7th largest investor with 0.5 bln euro of capital invested. The main sectors of Russian interests in Latvia are - gas supply, transport communications (transit corridors, banking and real estate. The article concludes that though the future of Russian-Latvian economic relations in the short-run is on a substantial pressure of geopolitical factors, the economic interests in mutual investment relations will prevail in the long-run perspectives.

  14. Household Credit Behaviour and Factors for Its Transformation: Evidence from Russian Monotown

    OpenAIRE

    Leonid A. Shafirov

    2016-01-01

    Current trends in Russian consumer lending, especially against the backdrop of economic crisis of recent years, highlight increasing relevance of the issue of sustainable household credit behavior. Survey conducted in December 2014 and January 2015 was focused on credit behavior of people who live in small depressed Russian monotown Gukovo (sample size is 80 respondents, with the total population of 65,4 thousand people as of January 1, 2015). The study aimed to provide empirical support for ...

  15. Health status of Russian minorities in former Soviet Republics.

    Science.gov (United States)

    Groenewold, W G F; van Ginneken, J K

    2011-08-01

    To examine if, and to what extent, disparities in health status exist between ethnic Russians and the native majority populations of four former Soviet Republics; and to determine to what extent indicators of socio-economic status and lifestyle behaviours explain variations in health status. Data from the World Health Organization's World Health Surveys of former Soviet Republics that include information on ethnicity (i.e. Estonia, Latvia, Ukraine, Kazakhstan and Russia) were used. Russia was included as the benchmark population as it is the country of origin of ethnic Russians. Data were collected from respondents aged ≥25 years in 2001-2003. Principal component analysis was used to derive the Health Status Index and Household Wealth Index. Multiple classification analysis was applied to examine the effects of the determinants on health status, including ethnic group membership. In Estonia and Kazakhstan, ethnic Russians have, on average, a lower health status than members of the majority population, while their health status is higher in Ukraine. Higher levels of material wealth, educational attainment and physical activity were associated with a higher health status. The association of these variables with health status was often stronger than the association between ethnic group membership and health status. Differences in health status between Russian ethnic minorities and the majority populations were found in Estonia and Kazakhstan, but were non-existent in Latvia and were the opposite of what was expected in Ukraine. Use of the Health Status Index in combination with multiple classification analysis proved to be a useful approach to examine health status differentials, and to identify and profile vulnerable groups in a society. Copyright © 2011 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  16. Microsatellite Markers for Russian Olive (Elaeagnus angustifolia; Elaeagnaceae

    Directory of Open Access Journals (Sweden)

    John F. Gaskin

    2013-09-01

    Full Text Available Premise of the study: Microsatellite markers were developed for the plant species Elaeagnus angustifolia to assist in future investigations of genetic variability in its native and invasive ranges and the precise origins of the United States/Canada invasion. Methods and Results: Eleven polymorphic microsatellite markers were developed. The number of alleles observed for each locus ranged from three to 11. Conclusions: These microsatellites have sufficient potential variability to define population structure and origins of the Russian olive invasion.

  17. Healthy Living

    Science.gov (United States)

    ... Health Menu Topics Environment & Health Healthy Living Pollution Reduce, Reuse, Recycle Science – How It Works The Natural World Games ... Lessons Topics Expand Environment & Health Healthy Living Pollution Reduce, Reuse, Recycle Science – How It Works The Natural World Games ...

  18. Sleep Duration, Exercise, Shift Work and Polycystic Ovarian Syndrome-Related Outcomes in a Healthy Population: A Cross-Sectional Study.

    Science.gov (United States)

    Lim, Audrey J R; Huang, Zhongwei; Chua, Seok Eng; Kramer, Michael S; Yong, Eu-Leong

    2016-01-01

    Few studies have examined the associations between sleep duration, shiftwork, and exercise to the infrequent menstruation, hyperandrogenism, and ovarian morphological changes observed in women with polycystic ovarian syndrome (PCOS). To examine whether lifestyle factors, including short sleep duration, insufficient exercise, and shiftwork, alone or in combination, are associated with the reproductive and metabolic abnormalities typical of PCOS in a healthy population. Prospective cross-sectional study of 231 women, including healthcare workers recruited for an annual health screen, healthy referral patients from the Women's Clinic and volunteers from the university community at the National University Hospital, Singapore, from 2011 to 2015. The women completed a questionnaire, including their menstrual cycle length, sleep length, frequency of exercise and shift work. Hyperandrogenism (hirsutism score, testosterone, sex hormone binding globulin (SHBG)), ovarian morphology and function (anthral follicle count, ovarian volume, anti-mullerian hormone (AMH)), and metabolic measures (body mass index (BMI), waist hip ratio (WHR), blood pressure, fasting glucose, fasting insulin and fasting lipids) were examined through anthropometric measurements, transvaginal ultrasound scans, and blood tests. No significant associations were observed between shift work, exercise or sleep duration and the androgenic and ovarian measures that define PCOS. However, women reporting fewer than 6 hours of sleep were more likely to report abnormal (short or long) menstrual cycle lengths (OR = 2.1; 95% CI, 1.1 to 4.2). Women who reported fewer than 6 hours of sleep had increased fasting insulin levels (difference in means = 2.13; 95% CI, 0.27 to 3.99 mU/L) and higher odds of insulin resistance (OR = 2.58; CI, 1.16 to 5.76). Lack of regular exercise was associated with higher mean fasting insulin (difference in means = 2.3 mU/L; 95% CI, 0.5 to 4.1) and HOMA-IR (difference in means = 0.49; 95% CI

  19. THE MYTH OF THE RUSSIAN EXISTENTIAL THREAT

    Science.gov (United States)

    2016-04-01

    Putin’s intent. What we can do is learn from his actions, and what we see suggests growing Russian capabilities, significant military modernization...AU/ACSC/POWELL, N/AY16 AIR COMMAND AND STAFF COLLEGE AIR UNIVERSITY THE MYTH OF THE RUSSIAN EXISTENTIAL THREAT...The methodology focuses on Russian capability, capacity, and intention to threaten NATO members’ existence. While Russia does possess nuclear weapons

  20. Russian Model Of The Administrative Justice

    Directory of Open Access Journals (Sweden)

    Natalja I. Jaroshenko

    2014-12-01

    Full Text Available On December 25, 2014 it would be twenty-one year since the Constitution of the Russian Federation was adopted on the national referendum on December 12, 1993. During this time, almost all constitutional provisions are implemented. The key point of course was the judicial reform in Russia, launched simultaneously with the adoption of Constitution of the Russian Federation. Adopted the new Civil Procedural Code, Criminal Procedural Code, Arbitration Procedural Code of the Russian Federation, Federal Constitutional Law "On the Constitutional Court of the Russian Federation", Federal Constitutional Law "On the courts of general jurisdiction in Russia", Federal Constitutional Law "On the Supreme Court of the Russian Federation". However, during twenty-one year of Russian Constitution work, the question on establishment of administrative courts in our country has not been resolved. Merger of the Supreme Court and the Supreme Arbitration Court of the Russian Federation, which happened in the year 2014, also shown the need to resolve the status of administrative courts in Russia. Previously submitted to the State Duma of the Federal Assembly of the Russian Federation the draft of the Federal Constitutional Law "On the Federal Administrative Courts in the Russian Federation" and is on the revision, which does not correspond to changes in the judicial system of the Russian Federation. Despite the failure of the Federal Constitutional Law "On the Federal Administrative Courts in the Russian Federation", in the opinion of the author, and it should be called that way, it Russia has already developed an own model of the Russian administrative justice, which is very specific.

  1. Contaminant transport modeling studies of Russian sites

    International Nuclear Information System (INIS)

    Tsang, Chin-Fu

    1993-01-01

    Lawrence Berkeley Laboratory (LBL) established mechanisms that promoted cooperation between U.S. and Russian scientists in scientific research as well as environmental technology transfer. Using Russian experience and U.S technology, LBL developed approaches for field investigations, site evaluation, waste disposal, and remediation at Russian contaminated sites. LBL assessed a comprehensive database as well as an actual, large-scale contaminated site to evaluate existing knowledge of and test mathematical models used for the assessment of U.S. contaminated sites

  2. Russian- Chinese relations : towards an energy partnership

    OpenAIRE

    Garanina, Olga

    2007-01-01

    18 p.; This paper aims to investigate the Russian-Chinese energy relations in the context of evolution of bilateral strategic relations since 1991.The research is focused on Russia and encompasses three main aspects: strategic approach of Russian-Chinese relations, Russian hydrocarbons production and export potential and prospects for the Eastern Russia. The paper is based on qualitative analysis. It shows that the framework of bilateral relations is globally favourable for creation of costly...

  3. The Potential of Modern Russian Generations

    Directory of Open Access Journals (Sweden)

    Valentina Grigor’evna Dobrokhleb

    2016-05-01

    Full Text Available The paper considers the necessity of socio-demographic approach to assessing the potential of modern generations. The demographic potential of generations is determined by their number, their share in total population, and their life expectancy. Their economic potential is determined by the proportion of representatives of different generations in total employment. Their social potential is determined by the system of values of generations. The rapid growth of differences in these characteristics leads to the break up of intergenerational relations and is connected with the aggravation of social contradictions. The potential of modern generations can be considered in different aspects: number of generations, life expectancy at birth, the share of representatives of different generations that share or do not share the basic social values of the society, including values related to reproductive and other types of demographic behavior. In order to identify existing differences between generations in the framework of the socio-demographic approach, the paper analyzes the dynamics of the number of young people in 1926, 1936, 2014 in the Russian Federation; the authors also carry out a comparative analysis of the secondary and authors’ sociological data of values-related and reproductive attitudes of conditionally parental and child generations. Russian researchers studied the life potential of the population and proved that in 1990–2010, the life potential of Russia’s population decreased. Reduction in the life potential in the population in general is associated with a decrease in this indicator for the younger generation (children’s ages due to the reduction in the number and proportion of this generation in the population structure. The reduction in the life potential has not stopped because the number of the younger generation continues to decrease. However, life expectancy in this period increased. Nevertheless, in general, mortality in

  4. Russian consumers' motives for food choice.

    Science.gov (United States)

    Honkanen, Pirjo; Frewer, Lynn

    2009-04-01

    Knowledge about food choice motives which have potential to influence consumer consumption decisions is important when designing food and health policies, as well as marketing strategies. Russian consumers' food choice motives were studied in a survey (1081 respondents across four cities), with the purpose of identifying consumer segments based on these motives. These segments were then profiled using consumption, attitudinal and demographic variables. Face-to-face interviews were used to sample the data, which were analysed with two-step cluster analysis (SPSS). Three clusters emerged, representing 21.5%, 45.8% and 32.7% of the sample. The clusters were similar in terms of the order of motivations, but differed in motivational level. Sensory factors and availability were the most important motives for food choice in all three clusters, followed by price. This may reflect the turbulence which Russia has recently experienced politically and economically. Cluster profiles differed in relation to socio-demographic factors, consumption patterns and attitudes towards health and healthy food.

  5. Implementing a Mentally Healthy Schools Framework Based on the Population Wide Act-Belong-Commit Mental Health Promotion Campaign: A Process Evaluation

    Science.gov (United States)

    Anwar-McHenry, Julia; Donovan, Robert John; Nicholas, Amberlee; Kerrigan, Simone; Francas, Stephanie; Phan, Tina

    2016-01-01

    Purpose: Mentally Healthy WA developed and implemented the Mentally Healthy Schools Framework in 2010 in response to demand from schools wanting to promote the community-based Act-Belong-Commit mental health promotion message within a school setting. Schools are an important setting for mental health promotion, therefore, the Framework encourages…

  6. Parenting Self-Efficacy, Parent Depression, and Healthy Childhood Behaviors in a Low-Income Minority Population: A Cross-Sectional Analysis.

    Science.gov (United States)

    Heerman, William J; Taylor, Julie Lounds; Wallston, Kenneth A; Barkin, Shari L

    2017-05-01

    Objectives Childhood obesity prevention and treatment depends, in part, on parents acting as agents of change for their children. Our objective was to measure the associations between parenting self-efficacy, parent depressive symptoms, and preschool child behaviors that support healthy growth. Methods We performed a cross-sectional analysis of baseline data from a randomized controlled trial. Parenting self-efficacy was measured using a 5-item version of the Parenting Sense of Competence (PSOC-5) scale (α= 0.8). Parent depressive symptoms were measured using the Center for Epidemiological Studies-Depression (CESD) scale. Child outcomes included diet (24 h diet recall), physical activity (accelerometry), sleep (parent-report), and media use during meals (parent-report). We performed separate multiple linear regressions for each outcome controlling for other covariates. Results The sample consisted of 601 parent-child pairs. Median child age was 4.3 (IQR 3.6-5.1) years; median child body mass index (BMI) percentile was 79.1% (IQR 66.8-88.5%); 90% of children were Hispanic/Latino, and 6% of children were non-Hispanic Black. Median parent age was 31.5 (IQR 27.6-36.0) years; 22% of parents met criteria for depression. Parenting self-efficacy (median PSOC-5 25; IQR 24-28) was negatively correlated with depressive symptoms (ρ = -0.16; p self-efficacy was associated with duration of child's sleep and fewer meals eaten in front of a TV (p self-efficacy and parental depressive symptoms on child sleep duration (p self-efficacy and depressive symptoms were not significantly associated with child physical activity or child diet. Conclusions In this minority population, higher parenting self-efficacy was associated with longer child sleep and fewer meals in front the TV, but parent depressive symptoms mitigated that protective effect for child sleep duration.

  7. Does vaccination ensure protection? Assessing diphtheria and tetanus antibody levels in a population of healthy children: A cross-sectional study.

    Science.gov (United States)

    Gowin, Ewelina; Wysocki, Jacek; Kałużna, Ewelina; Świątek-Kościelna, Bogna; Wysocka-Leszczyńska, Joanna; Michalak, Michał; Januszkiewicz-Lewandowska, Danuta

    2016-12-01

    Vaccination effectiveness is proven when the disease does not develop after a patient is exposed to the pathogen. In the case of rare diseases, vaccination effectiveness is assessed by monitoring specific antibody levels in the population. Such recurrent analyses allow the evaluation of vaccination programs. The primary schedule of diphtheria and tetanus vaccinations is similar in various countries, with differences mainly in the number and timing of booster doses. The aim of the study was to assess diphtheria and tetanus antibody concentrations in a population of healthy children.Diphtheria and tetanus antibody levels were analyzed in a group of 324 children aged 18 to 180 months. All children were vaccinated in accordance with the Polish vaccination schedule.Specific antibody concentrations greater than 0.1 IU/mL were considered protective against tetanus or diphtheria. Levels above 1.0 were considered to ensure long-term protection.Protective levels of diphtheria antibodies were found in 229 patients (70.46%), and of tetanus in 306 patients (94.15%). Statistically significant differences were found in tetanus antibody levels in different age groups. Mean concentrations and the percentage of children with high tetanus antibody titers increased with age. No similar correlation was found for diphtheria antibodies. High diphtheria antibody levels co-occurred in 72% of the children with high tetanus antibody levels; 95% of the children with low tetanus antibody levels had low levels of diphtheria antibodies.The percentage of children with protective diphtheria antibody levels is lower than that in the case of tetanus antibodies, both in Poland and abroad, but the high proportion of children without diphtheria protection in Poland is an exception. This is all the more puzzling when taking into account that Polish children are administered a total of 5 doses containing a high concentration of diphtheria toxoid, at intervals shorter than 5 years. The decrease in

  8. Sustainable development of Russian regions

    Directory of Open Access Journals (Sweden)

    V. D. Kuz’menkova

    2016-01-01

    Full Text Available Sustainable development of administrative-territorial units (ATU refers to the main directions of Russian Federation state policy to ensure the security of the national economy to meet the vital needs of people and the preservation of such a possibility for the future generations. The article describes and analyzes the factors that have the most significant impact on the level of ATE development. The dynamics of the gross output of agriculture in Russia and its critical evaluation are presents. It was revealed that the development of the region is the basis of the national economy security. At present, the concept of “sustainable development” in Russia is relevant and the role of regions in the sustainable development of the Russian Federation is constantly increasing. Stability of self-financing of the regional economy is achieved through conducting effective fiscal, financial, credit, tax and price policy, establishment of equal inter-budgetary relations with the federal center, the development of the securities market, increasing the volume of exports. Conducted research allowed: to identify the main factors influencing the sustainable development of Russia regions. The reasons for the backlog of economy of the Smolensk region of the nationwide growth rate and direction of their elimination are examined. Formation of the forecast of domestic agriculture development in the period up to 2020 should be based on the priority position of the industry in the agricultural sector, which is determined by its decisive role in meeting the population’s needs for basic food products. Prospective volumes of production of major agricultural products are based on the need to meet the challenges provided by the Russian Federation Government Decree.

  9. Russian autonomous labor colony in the People’s Republic of Tuva as a unique case of Russian regionalism

    Directory of Open Access Journals (Sweden)

    Vladimir G. Dazishen

    2016-09-01

    Full Text Available The article examines the experience of Russian regionalism in mid-19th – early 20th century Tuva, which took shape of setting up a colony of Russian subjects and became one of the most powerful factors behind the declaration of the People’s Republic of Tuva. Russian Autonomous Labor Colony (RALC was established in early 1920s and lasted for 10 years as a unique political entity in the history of Russia. RALC was fully controlled by official representatives of the Soviet state. Its stable population of over 10000 was mainly involved in cattle breeding, agriculture, crafts and even trade. RALC had its own legislation which even provided for certain elements of statehood. It was allowed to create its own flag and emblem, control its budget, and had its own military unit. The land under use by the colonists was on official lease from the government of the People’s Republic of Tuva (PRT. Ethnic Russians with Soviet citizenship complied with the legislation of the RSFSR. RALC had its own court, with convicted criminals serving their sentence in the PRT. Both RALC and PRT passed through several stages of increasingly radical left-wing reforms, which gave Moscow a firm grip over the local political establishment. In the second half of the decade the sociopolitical structure that included the RALC started to crumble away. On May 24, 1932, the autonomy was abolished by the new USSR-PRT agreement that oversaw the transformation of the colony’s remnants into Committees of Soviet Citizens. The article introduces a number of unpublished or little-known documents from the state archives of Krasnoyarsk, Novosibirsk, Irkutsk and other cities of the Russian Federation.

  10. Nuclear knowledge management: Russian lessons

    International Nuclear Information System (INIS)

    Gagarinski, A.; Yakovlev, N.

    2004-01-01

    Full text: Union, the issue of generation and accumulation of nuclear knowledge and human resources for realizing this knowledge in practice, have received strong governmental support, and were subject to strict control of the state. This policy, despite the well-known Russian difficulties related to the lag of computational base and complicated scientific and technical exchange with the West ('Iron Curtain'), in the 50-70's has made it possible both to solve the required defence tasks and ensure development of peaceful nuclear energy applications in the Soviet Union. The report briefly summarizes the main achievements in the field of nuclear knowledge management strategy in the period of fast nuclear energy deployment, which include: - establishment, on the base of the 'Uranium Project' founder institutions, of a series of nuclear science and engineering centers (Arzamas, Dimitrovgrad, Dubna, etc.), both within the nuclear branch and in the USSR and Soviet Republics' Academies of Science; - formation of scientific schools headed by eminent scientists, on the base of major nuclear energy issues, gathering creative teams with 'natural' nuclear knowledge transfer; - harmonious nuclear education system, including a large network of higher professional education institutions, which had a principal achievement - close relationship with the leading nuclear research centers; - creation of a regional centers' network intended for regular retraining of nuclear specialists; - creation and development of national centers for collecting, processing and evaluation of nuclear and other data (materials, thermal physics, etc.) necessary for nuclear engineering, as well as for development of algorithms and codes. Russian nuclear program as a whole, and KNM system in particular, received three severe crises in a short time period: - Chernobyl accident (1986); - restructuring of the political system (end of 80's - beginning of 90's); - collapse of the Soviet Union (1991). The report

  11. Industrial and institutional restructuring of the Russian electricity sector: Status and issues

    International Nuclear Information System (INIS)

    Engoian, Alda

    2006-01-01

    The reform of the Russian electricity industry represents one of the largest and most technically complex post-Soviet era industrial restructurings. This paper presents the framework, status, and perspectives for the Russian electricity sector liberalisation. Uncertainties regarding the effective implementation of the reform are specifically examined. Ultimately the critical analysis of the reform questions the feasibility and adequacy of the recommended measures in the specific Russian context. Current theories fail to answer a fundamental issue, namely how to promote investment in an obsolete electrical infrastructure and, more generally, whether a pure free market model is compatible with physical constraints posed by the electricity sector. A careless deregulation of the Russian electricity system could hinder the country's stable and sustainable development, as its economy and the population's service have traditionally been closely linked to the electricity industry

  12. Industrial and institutional restructuring of the Russian electricity sector: status and issues

    International Nuclear Information System (INIS)

    Engoian, A.

    2006-01-01

    The reform of the Russian electricity industry represents one of the largest and most technically complex post-Soviet era industrial restructurings. This paper presents the framework, status, and perspectives for the Russian electricity sector liberalisation. Uncertainties regarding the effective implementation of the reform are specifically examined. Ultimately the critical analysis of the reform questions the feasibility and adequacy of the recommended measures in the specific Russian context. Current theories fail to answer a fundamental issue, namely how to promote investment in an obsolete electrical infrastructure and, more generally, whether a pure free market model is compatible with physical constraints posed by the electricity sector. A careless deregulation of the Russian electricity system could hinder the country's stable and sustainable development, as its economy and the population's service have traditionally been closely linked to the electricity industry. (author)

  13. Factors and prospects of modernization of Russian regions development

    Directory of Open Access Journals (Sweden)

    Chernova Marija

    2016-03-01

    Full Text Available The content and efficiency of implementation of modernization processes in the economic system are, on the one hand, determined by the potential of the system and on the other hand by the consumers’ demand for manufactured modernization products (services. The article identifies and analyzes the main macroeconomic indicators that determine the prospects for modernization reforms in the economy of the Russian regions. Taking into consideration the fact, that for most Russian regions the greatest potential of modernization in the implementation of the projects of import substitution lies in the sphere of agricultural production, the consumer preferences of the population regarding domestic and foreign food products are assessed. Conclusion on priority measures for improving the competitiveness of domestic production in the framework of implementation of non-raw materials model of development of the domestic economy is made.

  14. Vyatka and Vyatkans in the Russian Linguistic Tradition

    Directory of Open Access Journals (Sweden)

    Elena D. Kazakova

    2011-12-01

    Full Text Available The article reconstructs the image of Vyatka Region and its population with reference to the vocabulary (both common and proper of Russian popular subdialects and national language. The analysis is made with reference to the Vyatka toponym derivatives, idiomatic expressions and free phrases with toponymic and the corresponding katoikonymic derivatives. Additionally, the author studies the Khlynov and Kirov toponymic derivatives, the former being the original, and the latter – the modern names of the capital of the region. The nominator’s point of view – i.e. inner (Vyatkans’ attitude, outer (neighbours’ attitude, and supraterritorial (Russian population’s attitude – turns out significant for image reconstruction, Vyatkans’ neighbours’ point of view being most fully and vividly reflected in the image thereof. Vyatka’s linguistic image is dominated by the idea of its inhabitants, Vyatkans, their features, character, and language.

  15. Values and education: Russian perspective

    Directory of Open Access Journals (Sweden)

    Borytko Nikolai M.

    2005-01-01

    Full Text Available This article is about some lessons of the multi-cultural analysis of a joint Russian-British educational project. The analysis, based on the achievements of Russian pedagogical science, about the achievement of the most effective cross-cultural communication, can be listed among the outcomes of the project, along with the applied results, which consists in developing an educational management training program. The growth of innovation process and international contacts in education testifies to the fact that education culture is evolving toward a new quality. In the evolution/process, the basic needs of schools, teachers and education managers are identified and conceptualized. Sharing achievements and discoveries in professional growth should be kept in mind and that fulfilling the needs can only take place within the context of the cultural-pedagogic position inherent to an individual teacher, a group of teachers, or a school. From the point of view of cross-cultural analysis, the specifics lie in the inherent values and the level at which the activity is typically performed. This analysis equips the researcher with the criteria necessary for identifying the culture type dealt with. This latter can be used then as a tool for analyzing and designing innovations.

  16. Factors fragmenting the Russian Federation

    Energy Technology Data Exchange (ETDEWEB)

    Brown, E.

    1993-10-06

    This paper examines the factors that threaten the future of the Russian Federation (RF). The observations are based on a study that focused on eight republics: Mordova, Udmurtia, Tatarstan, Mari El, Bashkortostan, Kabardino-Balkaria, Buryatia, and Altay Republic. These republics were selected for their geographic and economic significance to the RF. Tatarstan, Bashkortostan, Udmurtia, and Mari El are located on important supply routes, such as the Volga River and the trans-Siberian railroad. Some of these republics are relatively wealthy, with natural resources such as oil (e.g., Tatarstan and Bashkortostan), and all eight republics play significant roles in the military-industrial complex. The importance of these republics to the RF contrasts to the relative insignificance of the independence-minded Northern Caucasus area. The author chose not to examine the Northern Caucasus region (except Kabardino-Balkaria) because these republics may have only a minor impact on the rest of the RF if they secede. Their impact would be minimized because they lie on the frontiers of the RF. Many Russians believe that {open_quotes}it might be best to let such a troublesome area secede.{close_quotes}

  17. Studying The Great Russian Revolution

    Directory of Open Access Journals (Sweden)

    A. V. Torkunov

    2017-01-01

    Full Text Available The article revises an established view of Russian Revolution as two separate events - February Revolution and October Revolution. The author supports the concept of the «Great Russian Revolution», which unites these two events in a single process of revolutionary development. The author draws attention to the following advantages of the concept under consideration. First, it conceptualizes the revolution as a process contingent of a local and global historical context. In this sense, the revolution is presented as the transition of society to the modern stage of development, meaning the transition to modernity. Second, revolutionary events in Russia are considered from the point of view of the evolution of the spatial and socioeconomic distribution and rearrangement of key social groups: peasantry, elites, national and ethnic minorities. Third, it takes into account the personal factor in the revolutionary events, the influence of individual personalities on escalation or the reduction of socio-political tensions. Fourth, it draws attention to the fact that revolutions imply the use of various forms of political violence. Each revolution is characterized by a unique correlation of forms and intensity of political violence. Finally, it gives a normative assessment of the Revolution, encouraging a national discussion on the results and consequences of this great event.

  18. Analysis of experience of legal regulation in the sphere of public administration of sanatorium providing of children in the Russian Federation

    Directory of Open Access Journals (Sweden)

    Kovalenko T.Yu.

    2014-03-01

    Full Text Available Motherhood and childhood are one of the main priorities of the government social policy for any country. The Ukrainian state, its President and government are keeping under scrutiny issues of improving quality of life and health of population, in particular, health of women and children. Continuing study of problems of Public Administration in the sphere of health resort services for children in Ukraine, in her previous scientific publications the author drew attention to insufficient scope of researches and weak grounds of theoretical justification of possible organizational changes in this sphere. This very fact stipulates the necessity to continue thorough scientific research and study, first of all, a positive experience of foreign countries as to implementing reforms in the sphere of health resort services for children. The share of separate factors of different nature, impacting indicators of public health depends on age, sex and individual-typological characteristics of a person. However, the greatest impact on a human health is made by his lifestyle that may be attributed to conditionally controlled process. In this case, it is appropriate to note that the controlled impact on lifestyle can be made both by internal factors (e.g., motivation, and external factors. One of the most powerful external factors of controlled impact on the public health is health resort provision. The experience of the Russian Federation in this area is extremely useful for the Ukrainian state, which is actively promoting the idea of the health system modernization in the domestic market as the area in need of such changes. Now, 1997 health resorts are operating in the Russian Federation, annually serving approximately 6 million people. The jurisdiction of the Ministry of Health and Social Development of the Russian Federation encompasses 51 health resort facilities (HRF providing a wide range of health-improving services. The laws, government regulations

  19. The Use of Migrant Labour — Threat or Advantage for Russian Economical Development?

    Directory of Open Access Journals (Sweden)

    Viktoria Aleksandrovna Koretskaya-Garmash

    2016-06-01

    Full Text Available The article is devoted to a relevant problem of labour migration, the potentially possible threats and advantages of attracting and using of foreign migrant labour in the framework of the Russian economy are considered. The purpose of this work is to establish the how the migration processes influence over the current state of the Russian economy, and whether it is possible to meet the demand in the labour force by attracting labour migrants. The research method is the analysis of the statistical indicators of the Russian regions’ development, of demographic, migratory and financial situations in the Russian Federation. The results of the study are presented in the form of a quantitative assessment of the potential threats to the internal market due to the use of external migrant labour, which has already led to the Russian economic disruption, the devaluation of the Russian ruble, the growth of current account deficit, the load on the pension system of Russia. Therefore, we must not forget the positive aspects — rejuvenation of the age composition of the population, occupation of vacant jobs by the workers in the disadvantaged Russian regions, the increasing size of tax revenues to the Russian budget system by filing patents on employment activity. The presented results of the study can be used by public authorities in the migration policy, labour and social work for the development of the state programme stimulating internal and external migrants for employment in the regions with a shortage of manpower. The conducted research allows to define the relationship between labour migrants and economic activity of local population, to characterize the reasons of external labour migration and to analyse the consequences of migration for the host country

  20. Basic guide of modern Russian education

    OpenAIRE

    Ibragimova, Liliya; Rodikov, Alexander

    2014-01-01

    This article is devoted to the study of the problems of modern Russian education in the context of globalization of the world of education. The publication addresses the main guide of the modern Russian education. It presents an analysis of contemporary processes of globalization and their impact on the international scientific community.

  1. Legal Portion in Russian Inheritance Law

    Science.gov (United States)

    Inshina, Roza; Murzalimova, Lyudmila

    2013-01-01

    In this paper the authors describe the right to inherit as one of the basic human rights guaranteed by the Constitution of the Russian Federation. The state has set rules according to which after a person's death, his or her property is inherited by other persons. The Russian civil legislation establishes the institution of legal portions that is…

  2. Heutiges Russisch (2) (Contemporary Russian [2])

    Science.gov (United States)

    Russisch, 1976

    1976-01-01

    Considers contemporary Russian usage with regard to variations in the genitive, accusative and nominative inflections and the synonymity of full and shortened adjective forms. Material is excerpted from "Stilistik der russischen Sprache" (Russian Language Style) by D. Rosental and M. Telenkowa. (Text is in German.) (FB)

  3. Heutiges Russisch (Schluss) (Contemporary Russian [Conclusion])

    Science.gov (United States)

    Russisch, 1976

    1976-01-01

    Considers two aspects of contemporary Russian language usage: (1) synonymity of prepositions, and (2) semantic and stylistic differences arising when certain verbs govern nouns in different cases. Material is excerpted from "Stilistik der russischen Sprache" (Russian Language Style) by Rosental and M. Telenkowa. (Text is in German.) (FB)

  4. Lexical Inferencing in Reading L2 Russian

    Science.gov (United States)

    Comer, William J.

    2012-01-01

    This study describes how intermediate-level first language English readers of Russian as a second language deploy lexical inferencing and other strategies when reading informational texts. Fifth-semester students of Russian performed think-alouds while reading two texts; one written for the general adult reader, and the other meant for school-age…

  5. The Russian Novel, Literature: 5113.88.

    Science.gov (United States)

    Dade County Public Schools, Miami, FL.

    Developed for a high school quinmester unit on the Russian novel, this guide is designed to give students the opportunity to become familiar with the major works of Leo Tolstoy and Fyodor Dostoevski. Performance objectives for the course include studying the general facets of 19th century Russian culture and history, analyzing the novels of…

  6. Electronic Repository of Russian Historical Statistics

    NARCIS (Netherlands)

    Tykhonov, Vyacheslav; Kessler, Gijs; Markevich, Andrei; de Vries, Jerry

    2014-01-01

    The Electronic Repository for Russian Historical Statistics brings together data extracted from various published and unpublished sources in one place. Its principal focus is Russian economic and social history of the last three centuries (18th-21st). The repository caters to the needs of the

  7. An Analysis of Ratings of Russian Banks

    NARCIS (Netherlands)

    van Soest, A.H.O.; Peresetsky, A.; Karminsky, A.M.

    2003-01-01

    Since the recent financial crisis, both the Russian business community and foreign investors have started to make more and more use of ratings of the reliability of Russian banks, i.e., their ability to meet interest and repayment commitments to the investors.In response to this, the number of

  8. Russian Media Education Researches: 1950-2010

    Science.gov (United States)

    Federov, Alexander

    2010-01-01

    This article analyzed the development of Russian media education researches from 1950 to 2010 years. The list of theses of the Russian authors on the subject of Media Education is about 180 titles since 1950. Nearly 70 of them have been defended for the recent 10 years. From 1950 till 1959 six theses were defended, from 1960 till 1969--15; from…

  9. Russian gas in the west European market

    International Nuclear Information System (INIS)

    Nikitin, B.A.

    1996-01-01

    The paper relates to the Russian supply of natural gas to the west European market. Following themes are discussed: The resource basis of the gas industry; analysis of the European gas market; projects for Russian gas supply to Europe; international co-operation

  10. A study on single nucleotide polymorphism of exon 7 T/C (locus 593 of platelet-activating factor acetylhydrolase gene in healthy Han population in the Shanghai region

    Directory of Open Access Journals (Sweden)

    Tian-bao XIA

    2012-08-01

    Full Text Available Objective To investigate the distribution of single nucleotide polymorphism (SNP in platelet-activating factor acetylhydrolase (PAF-AH gene exon 7 T/C (locus 593 in healthy Han population in Shanghai region and the features different from other races. Methods The SNP in PAF-AH gene exon 7 T/C (locus 593 was detected and analyzed by PCR and sequencing in 110 healthy Han people from Shanghai areas. The genotype and allele frequency were then calculated and compared with that in other races in combination with review of relevant literature. Results The amplified product of the SNP in PAF-AH gene exon 7 T/C (locus 593 was 240 bp in 110 healthy Han people, of whom 97 were with TT genotype and 13 with TC genotype, but no CC genotype was found. As to the allele frequency distribution, T type allele took the highest position, and C type followed. The genotype frequency of TT and TC was 88.2% and 11.8%, respectively, and they were markedly different from that in German population (0.95%, while not statistically significant different from that in British population (7.67%. Conclusions There exists SNP in PAF-AH gene exon 7 T/C (position 593 in healthy Han people in Shanghai region, with a higher frequency of T→C mutation. The mutational genotype frequency is found to be located at the locus 593 is 11.81%, and it is markedly different from that in German population, but not significantly different from that in British population.

  11. Changes in Anti-Müllerian Hormone (AMH) throughout the Life Span: A Population-Based Study of 1027 Healthy Males from Birth (Cord Blood) to the Age of 69 Years

    DEFF Research Database (Denmark)

    Aksglæde, Lise; Sørensen, K; Boas, Malene

    2010-01-01

    Context: Anti-Mu¨ llerian hormone (AMH), which is secreted by immature Sertoli cells, triggers the involution of the fetalMu¨ llerian ducts.AMHis a testis-specific marker used for diagnosis in infants with ambiguous genitalia or bilateral cryptorchidism. Aim: The aim of the study was to describe...... the ontogeny of AMH secretion through life in healthy males. Setting:This was a population-based study of healthy volunteers. Participants: Participants included 1027 healthy males from birth (cord blood) to 69 yr. A subgroup was followed up longitudinally through the infantile minipuberty [(in cord blood......AMHwas above the detection limit in all samples with a marked variation according to age and pubertal status. The median AMH level in cord blood was 148 pmol/liter and increased significantly to the highest observed levels at 3 months (P 0.0001). AMH declined at 12 months (P 0.0001) and remained...

  12. Multifractal structures for the Russian stock market

    Science.gov (United States)

    Ikeda, Taro

    2018-02-01

    In this paper, we apply the multifractal detrended fluctuation analysis (MFDFA) to the Russian stock price returns. To the best of our knowledge, this paper is the first to reveal the multifractal structures for the Russian stock market by financial crises. The contributions of the paper are twofold. (i) Finding the multifractal structures for the Russian stock market. The generalized Hurst exponents estimated become highly-nonlinear to the order of the fluctuation functions. (ii) Computing the multifractality degree according to Zunino et al. (2008). We find that the multifractality degree of the Russian stock market can be categorized within emerging markets, however, the Russian 1998 crisis and the global financial crisis dampen the degree when we consider the order of the polynomial trends in the MFDFA.

  13. The Russian nuclear data research programme

    International Nuclear Information System (INIS)

    1995-11-01

    The report contains the Russian programme of nuclear data research, approved by the Russian Nuclear Data Committee on 16 December 1994. It gives surveys on nuclear data needs, on the structure of nuclear data activities, on experimental facilities for nuclear data measurements at five Russian institutes, on theoretical model work, nuclear data evaluation, and nuclear data testing. It describes four Russian nuclear data centers and their relations to the International Nuclear Data Centres Network, and their holdings of nuclear data libraries of Russian and international origin. A summary of nuclear data applications in energy and non-energy fields is given. An appendix contains a detail nuclear data research programme for the years 1995 - 2005. (author). 16 refs, 1 fig., 6 tabs

  14. Healthy Weight

    Science.gov (United States)

    ... such diets limit your nutritional intake, can be unhealthy, and tend to fail in the long run. The key to achieving and maintaining a healthy weight isn't about short-term dietary changes. It's about a lifestyle that includes healthy eating, regular physical activity, and ...

  15. The association between the apolipoprotein B/A-I ratio and coronary calcification may differ depending on kidney function in a healthy population.

    Directory of Open Access Journals (Sweden)

    Seok-Hyung Kim

    Full Text Available The apolipoprotein B/A-1 ratio has been reported to be one of the strongest risk predictors of cardiovascular events. However, its prognostic value for cardiovascular disease is still uncertain, especially in patients with chronic kidney disease. This study aimed to investigate whether the association between the apolipoprotein B/A-I ratio and coronary artery calcification differed according to kidney function in a healthy population.Of the data from 7,780 participants from the medical records database in Gangnam Severance Hospital from 2005 through 2016, a cross-sectional analysis included participants with an estimated glomerular filtration rate (eGFR ≥ 60 mL/min/1.73 m2 determined based on the Chronic Kidney Disease -Epidemiology Collaboration equation (n  =  1,800. Mild renal insufficiency was defined as an eGFR of 60-90 mL/min/1.73 m2. Coronary artery calcification measured with computed tomography was defined as an above-zero score. Logistic regression analyses were used to determine the association between coronary calcification and the apolipoprotein B/A-I ratio according to eGFR by adjusting for the influence of confounders.The mean apolipoprotein B/A-I level was significantly higher in the participants with coronary artery calcification than in the participants without coronary artery calcification. The apolipoprotein B/A-I ratio was significantly different according to coronary artery calcification in the participants with normal kidney function, but in the participants with mild renal insufficiency, it was not different. After adjusting for age, male sex, systolic blood pressure, body mass index, current smoking status, and fasting plasma glucose, the apolipoprotein B/A-I ratio was significantly associated with an increased risk of coronary artery calcification in participants with normal kidney function (odds ratio = 2.411, p = 0.011, while in the participants with mild renal insufficiency, the apolipoprotein B/A-I ratio was

  16. Bioequivalence of 250 mg lysine clonixinate tablets after a single oral dose in a healthy female Mexican population under fasting conditions.

    Science.gov (United States)

    Marcelín-Jiménez, G; Angeles, A C P; García, A; Morales, M; Rivera, L; Martín-Del-Campo, A

    2010-05-01

    To evaluate the bioequivalence between two 250 mg-tablets of lysine clonixinate, Dorixina Forte (Siegfried Rhein, México) as reference product, and Prestodol (Farmaceúticos Rayere, S.A., México) as test formulation. 26 healthy adult female Mexican volunteers received a single oral dose of 250-mg lysine clonixinate under fasting conditions. The drug was administered following a randomized, two-period, two-sequence, cross-over design. Twelve serial blood samples were collected up to 8 h after dosing, and clonixin (CLX) was measured by ultra-performance liquid chromatography (UPLC) coupled with tandem mass spectrometry. Decimal logarithm values of Cmax and area under the curve (AUC) were used to construct a classic confidence interval at 90% (90% CI). Bioequivalence was established if 90% CI of mean ratios (test/reference) fall within the 0.8-1.25 range. Volunteers formed a homogeneous population in terms of age (27.2 +/- 6.3 years), weight (55.9 +/- 6.5 kg), height (1.6 +/- 0.04 m), and body mass index (BMI) (22.91 +/- 2.03 kg/m(2)). Reference formulation exhibited the following pharmacokinetics: C(max) (32.39 +/- 8.32 microg/ml); t(max) (0.64 +/- 0.2 h); AUC0-8h (48.92 +/- 16.51 microg x h/ml); t1/2 (1.3 +/- 0.24 h); CLapp (5.64 +/- 1.99 l/h), and Vdapp (10.22 +/- 2.9 l). Concerning bioequivalence, 90% CI were: C(max) (82.32 - 98.79), AUC0-t (94.59-106.29), and AUC(0-inf) (94.61-106.42), with a statistical power of > 0.90 at every tested interval. This single-dose study found that both 250-mg immediate-release tablets of lysine clonixinate met the Mexican regulatory criteria for bioequivalence in these volunteers.

  17. The association between personal sun exposure, serum vitamin D and global methylation in human lymphocytes in a population of healthy adults in South Australia

    Energy Technology Data Exchange (ETDEWEB)

    Nair-Shalliker, Visalini, E-mail: visalinin@nswcc.org.au [Cancer Research Division, Cancer Council New South Wales (Australia); Dhillon, Varinderpal [CSIRO Food and Nutritional Sciences (Australia); Clements, Mark [Department of Medical Epidemiology and Biostatistics, Karolinska Institutet (Sweden); Armstrong, Bruce K. [Sydney School of Public Health, University of Sydney (Australia); Fenech, Michael [CSIRO Food and Nutritional Sciences (Australia)

    2014-07-15

    Highlights: • Solar UV exposure is positively correlated with LINE 1 hypomethylation. • This was observed in human peripheral blood lymphocytes. • There was no evident effect modification by serum vitamin D (25OHD) levels. • This was observed in a population of healthy adults from South Australia. - Abstract: Background: There is a positive association between solar UV exposure and micronucleus frequency in peripheral blood lymphocytes (PBL) and this association may be stronger when serum vitamin D (25(OH)D) levels are insufficient (<50 nmol/L). Micronucleus formation can result from global hypomethylation of DNA repeat sequences. The aim of this analysis was to evaluate the relationship between solar UV exposure and methylation pattern in LINE-1 repetitive elements in PBL DNA and to see if serum 25(OH)D levels modify it. Method: Personal solar UV exposure was estimated from hours of outdoor exposure over 6 weeks recalled at the time of blood collection in 208 male and female participants living in South Australia. Methylation in LINE-1 repetitive elements was assessed in PBL using pyrosequencing. Results: Methylation in LINE-1 decreased with increasing solar UV exposure (% decrease = 0.5% per doubling of sUV; 95%CI: −0.7 to −0.2 p{sub value} = 0.00003). Although there was no correlation between LINE-1 methylation and micronucleus frequency, there was a 4.3% increase (95%CI: 0.6–8.1 p-value = 0.02) in nucleoplasmic bridges and a 4.3% increase in necrosis (CI: 1.9–6.8 p-value = 0.0005) for every 1% increase in LINE-1 methylation. Serum 25(OH)D was not associated with DNA methylation; or did it modify the association of solar UV with DNA methylation. Conclusion: Exposure to solar UV radiation may reduce DNA methylation in circulating lymphocytes. This association does not appear to be influenced or mediated by vitamin D status.

  18. Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population.

    Directory of Open Access Journals (Sweden)

    Katherine E Beaney

    Full Text Available Numerous risk prediction algorithms based on conventional risk factors for Coronary Heart Disease (CHD are available but provide only modest discrimination. The inclusion of genetic information may improve clinical utility.We tested the use of two gene scores (GS in the prospective second Northwick Park Heart Study (NPHSII of 2775 healthy UK men (284 cases, and Pakistani case-control studies from Islamabad/Rawalpindi (321 cases/228 controls and Lahore (414 cases/219 controls. The 19-SNP GS included SNPs in loci identified by GWAS and candidate gene studies, while the 13-SNP GS only included SNPs in loci identified by the CARDIoGRAMplusC4D consortium.In NPHSII, the mean of both gene scores was higher in those who went on to develop CHD over 13.5 years of follow-up (19-SNP p=0.01, 13-SNP p=7x10-3. In combination with the Framingham algorithm the GSs appeared to show improvement in discrimination (increase in area under the ROC curve, 19-SNP p=0.48, 13-SNP p=0.82 and risk classification (net reclassification improvement (NRI, 19-SNP p=0.28, 13-SNP p=0.42 compared to the Framingham algorithm alone, but these were not statistically significant. When considering only individuals who moved up a risk category with inclusion of the GS, the improvement in risk classification was statistically significant (19-SNP p=0.01, 13-SNP p=0.04. In the Pakistani samples, risk allele frequencies were significantly lower compared to NPHSII for 13/19 SNPs. In the Islamabad study, the mean gene score was higher in cases than controls only for the 13-SNP GS (2.24 v 2.34, p=0.04. There was no association with CHD and either score in the Lahore study.The performance of both GSs showed potential clinical utility in European men but much less utility in subjects from Pakistan, suggesting that a different set of risk loci or SNPs may be required for risk prediction in the South Asian population.

  19. Diffusion tensor imaging of the cervical spinal cord in healthy adult population: normative values and measurement reproducibility at 3T MRI.

    Science.gov (United States)

    Brander, Antti; Koskinen, Eerika; Luoto, Teemu M; Hakulinen, Ullamari; Helminen, Mika; Savilahti, Sirpa; Ryymin, Pertti; Dastidar, Prasun; Ohman, Juha

    2014-05-01

    Compared to diffusion tensor imaging (DTI) of the brain, there is a paucity of reports addressing the applicability of DTI in the evaluation of the spinal cord. Most normative data of cervical spinal cord DTI consist of relatively small and arbitrarily collected populations. Comprehensive normative data are necessary for clinical decision-making. To establish normal values for cervical spinal cord DTI metrics with region of interest (ROI)- and fiber tractography (FT)-based measurements and to assess the reproducibility of both measurement methods. Forty healthy adults underwent cervical spinal cord 3T MRI. Sagittal and axial conventional T2 sequences and DTI in the axial plane were performed. Whole cord fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were determined at different cervical levels from C2 to C7 using the ROI method. DTI metrics (FA, axial, and radial diffusivities based on eigenvalues λ1, λ2, and λ3, and ADC) of the lateral and posterior funicles were measured at C3 level. FA and ADC of the whole cord and the lateral and posterior funicles were also measured using quantitative tractography. Intra- and inter-observer variation of the measurement methods were assessed. Whole cord FA values decreased and ADC values increased in the rostral to caudal direction from C2 to C7. Between the individual white matter funicles no statistically significant difference for FA or ADC values was found. Both axial diffusivity and radial diffusivity of both lateral funicles differed significantly from those of the posterior funicle. Neither gender nor age correlated with any of the DTI metrics. Intra-observer variation of the measurements for whole cord FA and ADC showed almost perfect agreement with both ROI and tractography-based measurements. There was more variation in measurements of individual columns. Inter-observer agreement varied from moderate to strong for whole cord FA and ADC. Both ROI- and FT-based measurements are applicable

  20. Paradoxes of evidence in Russian addiction medicine.

    Science.gov (United States)

    Mendelevich, V D; Zalmunin, K Yu

    2015-01-01

    For many years, clinical protocols for treatment of drug abuse patients and treatment standards in Russian Federation were not grounded on the principles of evidence-based medicine [1]. Recommendations for use of certain drugs were not accompanied by any indication of the level of credibility of the evidence supporting it. The appearance in 2014 of such indications in clinical recommendations can be considered a significant step forward for the science of addiction medicine [2]. To compare Russian evidence and practice in addiction medicines with international standards. Situation and literature analysis. The analysis shows that in the wording of recommendations on the use of medicines, some were subject of serious methodological errors. For some drugs globally there is high quality evidence supporting effects of certain drugs globally, but this is not recognized in Russia. As a result, Russian standards of clinical care for the treatment of dependency syndrome are radically different to the standards of therapy, presented in the WHO recommendations. This is due both to the disregard of the meta-analyses presented in the Cochrane reviews and also to the specific bioethical preferences in drug treatment in Russia.It is known that there is no convincing data on the effectiveness and safety of antipsychotics in the treatment of alcohol dependence syndrome [3]. 13 randomized trials with a double blind placebo-controlled design involving 1593 patients assessing effects of amisulpride, aripiprazole, flupentixolum dekonoat, olanzapine, quetiapine, tiapride showed that antipsychotics do not result in abstinence, do not reduce abuse and do not stop craving in alcoholic patients: "Antipsychotics should not be used in patients with a primary diagnosis of dependence. Appointment of antipsychotics for the treatment of substance abuse disorders are contraindicated, since not only does it not improve the condition of patients, but it can even worsen the course of the disease

  1. Employment strategy of the Russians

    Directory of Open Access Journals (Sweden)

    Vladimir Borisovich Toreev

    2015-05-01

    Full Text Available During the crisis it is especially important to choose a correct employment strategy. Every employee uses an employment strategy, as he/she selects the direction of long-term employment consciously or intuitively. The choice of strategy is determined by a number of factors shaping the person’s attitudes: health, character, upbringing, education, social environment, institutional environment. The employment strategies of the young people newly entering the labor market differ from lab our strategies of workers. Young people do not have such experience and can plan their life “from scratch”. The Soviet specialists, people who started their career in the planned economy, have their own features of employment strategies. The article describes employment strategies of the Russians

  2. Russian Virtual Observatory: Data Sources

    Directory of Open Access Journals (Sweden)

    Malkov O.

    2016-03-01

    Full Text Available The purpose of this review is to analyze main directions of creation and functioning of major data sources developed by Russian astronomers or with their participation and to compare them with the worldwide trends in these fields. We discuss astronomical space missions of the past, present, and future (Astron, INTEGRAL, WSO-UV, Spectrum Roentgen Gamma, Lyra-B, high-quality photometric atlases and catalogues, and spectroscopic data sources, primarily VALD and the global VAMDC framework for the maintenance and distribution of atomic and molecular data. We describe collection, analysis, and dissemination of astronomical data on minor bodies of the Solar System and on variable stars. Also described is the project joining data for all observational types of binary and multiple stars, Binary star DataBase (BDB.

  3. Healthy Places

    Centers for Disease Control (CDC) Podcasts

    Every person has a stake in environmental public health. As the environment deteriorates, so does the physical and mental health of the people within it. Healthy places are those designed and built to improve the quality of life for all people who live, work, worship, learn, and play within their borders -- where every person is free to make choices amid a variety of healthy, available, accessible, and affordable options. The CDC recognizes significant health issues and places that are vital in developing the Healthy Places program and provides examples in this report.

  4. THE GREAT RUSSIAN SCIENTIST M.V. LOMONOSOV

    Directory of Open Access Journals (Sweden)

    G.L. Mikirtichan

    2011-01-01

    Full Text Available This article presents reflections on the contribution of the great Russian scientist, one of the most prominent world science stars Mikhail Lomonosov (8/19.11.1711–4/15.04.1765 in connection with the 300th anniversary of his birth celebrated in 2011. Particular attention is paid to his role as an advocate for the development of domestic education and science, and his views on medicine. In the same year we are celebrating the 250 years anniversary since M. Lomonosov’s writing the letter to I.I. Shuvalov, «On the saving and reproduction of the Russian People» (1761, which contained an extensive program of increasing the country's population,  which included a range of legal, social and medical measures to help increase fertility and reduce child mortality. Key words: M. V. Lomonosov, I. I. Shuvalov, Moscow University, «On the saving and reproduction of the Russian people». (Pediatric pharmacology. — 2011; 8 (6: 136–140.

  5. Development of Culturally Appropriate Support Strategies to Increase Uptake of Nicotine Replacement Therapy Among Russian- and Chinese-Speaking Smokers in New York City.

    Science.gov (United States)

    Quinn, Erin C; Sacks, Rachel; Farley, Shannon M; Thihalolipavan, Sayone

    2017-06-01

    Approximately 80,000 New York City smokers are Chinese or Russian speakers. To increase utilization of smoking cessation services among these populations, the Department of Health and Mental Hygiene developed linguistically and culturally tailored outreach strategies to promote and enhance its annual Nicotine Patch and Gum Program. In 2010, online web applications in Chinese and Russian were introduced. In 2011, input was sought from the community to develop Russian-language radio and newspaper ads, and a Russian-speaking liaison provided phone-assisted online enrollment support. In 2012, Chinese newspaper ads were introduced, and a Cantonese- and Mandarin-speaking liaison was hired to provide enrollment support. In 2010, 51 Russian speakers and 40 Chinese speakers enrolled in the program via web application. In 2011, 510 Russian speakers applied via the web application, with 463 assisted by the Russian-speaking liaison; forty-four Chinese speakers applied online. In 2012, 394 Russian speakers applied via the web application; 363 were assisted by the Russian-speaking liaison. Eighty-five Chinese smokers applied online via the web application; seventy were assisted by the Chinese-speaking liaison. Following the implementation of culturally tailored cessation support interventions, ethnic Russian smokers' uptake of cessation support increased tenfold, while Chinese smokers' uptake doubled. Although linguistically appropriate resources are an essential foundation for reaching immigrant communities with high smoking rates, devising culturally tailored strategies to increase quit rates is critical to programmatic success.

  6. Russkie v Latvii: osobennosti sociokul'turnoj adaptacii i identichnosti [Russians in Latvia: Peculiarities of Socio-cultural Adaptation and Identity

    Directory of Open Access Journals (Sweden)

    Voronov Viktor

    2009-01-01

    Full Text Available The author identifies trends and variations of the socio-cultural identity and integration of Russians in Latvia. According to the author, since the middle 1990s, two trends have been recognized - first, the “ingrowing” of ethnic Russians into the life of independent Latvia, and second, forming their new identity. The article presents a number of factors hampering the integration of ethnic Russians into Latvian society. Variations and options of socio-cultural identity and integration (or assimilation of the Russian population of Latvia are shown.

  7. Healthy Schools

    Science.gov (United States)

    ... Nutrition Facts School Meals Smart Snacks Celebrations & Rewards Food and Beverage Marketing Water Access Healthy Eating Learning Opportunities Staff ... Services Acute & Emergency Care Care Coordination Chronic Disease Management Family Engagement Chronic ... Allergies Oral Health Local School Wellness Policy Whole ...

  8. Health Care in the Russian Federation.

    Science.gov (United States)

    Younger, David S

    2016-11-01

    The Russian Federation health system has its roots in the country's complex political history. The Ministry of Health and Social Development and its associated federal services are the principal Russian institutions subserving the Russian Federation. Funding for the health system goes through 2 channels: the general revenue budget managed by federal, regional, and local health authorities, and the Mandatory Health Insurance Fund. Although the Soviet Union was the first country in the world to guarantee free medical care as a constitutional right to all its citizens, quality and accessibility are in question. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. The philosophical implications of Russian conceptualism

    Directory of Open Access Journals (Sweden)

    Mikhail Epstein

    2010-01-01

    Conceptualism identifies itself as a predominantly Russian-Soviet mode of thinking. In the West, the correlation between ideological signs and observable reality has been persistently validated through scientific and economic practice; while in Russia, traditionally, reality itself has been constructed from ideological signs generated by its ruling minds as a kind of hyper-reality. Thus, Russian Conceptualism sees itself not as a mere replica of Western postmodernism, but as a reflection of the underlying structures of Russian history, where the signs of reality have always been subject to ideological manipulation.

  10. Russian energy prices, taxes and costs 1993

    International Nuclear Information System (INIS)

    1994-01-01

    The Russian energy industry may be the country's most promising exporter, but it is struggling to free itself from the heavy regulation and economic distortions inherited from the Soviet era. This analysis examines Russian price and tax policies as well as production costs in 1993, and their effect on supply and demand in the oil, coal, gas and electricity sectors. The study underscores the broad consensus among both Western and Russian experts that primary energy prices should be lifted to world levels. It offers a framework for addressing the great question about how fast this should be done in a country undergoing a tremendous social and political transformation

  11. CORPORATIONS IN RUSSIAN ECONOMICS OF TODAY

    Directory of Open Access Journals (Sweden)

    S. A. Shirokovskikh

    2011-01-01

    Full Text Available In Russian economics there are purely Russian private corporations as well as mixed state/private owned and transnational corporations. Specific ways of forming corporations in Russia resulted in corporate management models different from those used abroad (exclusive of largest holdingcompanies with considerable participation of the state. Difference in the corporation forms is determined by relations between owners and top managers. Efficient and sustainable (in the western sense functioning of Russian corporations may become effective only after long timeprovided RF ownership right legislation gets simultaneously improved.

  12. Association between intake of less-healthy foods defined by the United Kingdom's nutrient profile model and cardiovascular disease: A population-based cohort study.

    Directory of Open Access Journals (Sweden)

    Oliver T Mytton

    2018-01-01

    Full Text Available In the United Kingdom, the Food Standards Agency-Ofcom nutrient profiling model (FSA-Ofcom model is used to define less-healthy foods that cannot be advertised to children. However, there has been limited investigation of whether less-healthy foods defined by this model are associated with prospective health outcomes. The objective of this study was to test whether consumption of less-healthy food as defined by the FSA-Ofcom model is associated with cardiovascular disease (CVD.We used data from the European Prospective Investigation of Cancer (EPIC-Norfolk cohort study in adults (n = 25,639 aged 40-79 years who completed a 7-day diet diary between 1993 and 1997. Incident CVD (primary outcome, cardiovascular mortality, and all-cause mortality (secondary outcomes were identified using record linkage to hospital admissions data and death certificates up to 31 March 2015. Each food and beverage item reported was coded and given a continuous score, using the FSA-Ofcom model, based on the consumption of energy; saturated fat; total sugar; sodium; nonsoluble fibre; protein; and fruits, vegetables, and nuts. Items were classified as less-healthy using Ofcom regulation thresholds. We used Cox proportional hazards regression to test for an association between consumption of less-healthy food and incident CVD. Sensitivity analyses explored whether the results differed based on the definition of the exposure. Analyses were adjusted for age, sex, behavioural risk factors, clinical risk factors, and socioeconomic status. Participants were followed up for a mean of 16.4 years. During follow-up, there were 4,965 incident cases of CVD (1,524 fatal within 30 days. In the unadjusted analyses, we observed an association between consumption of less-healthy food and incident CVD (test for linear trend over quintile groups, p < 0.01. After adjustment for covariates (sociodemographic, behavioural, and indices of cardiovascular risk, we found no association between

  13. The introduction of a breast cancer screening programme in a region with a population at medium risk for developing breast cancer: Khanty-Mansiysky autonomous Okrug?Ugra (Russian Federation)

    OpenAIRE

    Zakharova, N; Duffy, SW; Mackay, J; Kotlyarov, E

    2011-01-01

    Background: A breast cancer screening programme (BCSP) was started in 21 districts in the Khanty-Mansiysky Autonomous Okrug?Ugra region from 7 February 2007. Methods: From the data on the numbers of subjects screened and the resulting diagnoses we calculated screening coverage rates and cancer detection rates and estimated the sensitivity of the screening tests. The State Cancer Registry was the source for the data regarding the female population by age, the number of breast cancer cases and ...

  14. Consumo de bebidas para una vida saludable: recomendaciones para la población mexicana Beverage consumption for a healthy life: recommendations for the Mexican population

    Directory of Open Access Journals (Sweden)

    Juan A Rivera

    2008-04-01

    Population was convened by the Secretary of Health for the purpose of developing evidence-based guidelines for consumers, health professionals, and government officials. The prevalence of overweight, obesity and diabetes have dramatically increased in Mexico; beverages contribute a fifth of all calories consumed by Mexicans. Extensive research has found that caloric beverages increase the risk of obesity. Taking into consideration multiple factors, including the health benefits, risks, and nutritional implications associated with beverage consumption, as well as consumption patterns in Mexico, the committee classified beverages into six levels. Classifications were made based on caloric content, nutritional value, and health risks associated with the consumption of each type of beverage and range from the healthier (level 1 to least healthy (level 6 options, as follows: Level 1: water; Level 2: skim or low fat (1% milk and sugar free soy beverages; Level 3: coffee and tea without sugar; Level 4: non-caloric beverages with artificial sweeteners; Level 5: beverages with high caloric content and limited health benefits (fruit juices, whole milk, and fruit smoothies with sugar or honey; alcoholic and sports drinks, and Level 6: beverages high in sugar and with low nutritional value (soft drinks and other beverages with significant amounts of added sugar like juices, flavored waters, coffee and tea. The committee recommends the consumption of water as a first choice, followed by no or low-calorie drinks, and skim milk. These beverages should be favored over beverages with high caloric value or sweetened beverages, including those containing artificial sweeteners. Portion size recommendations are included for each beverage category and healthy consumption patterns for men and women are illustrated.

  15. Results of national lake surveys 1995 in Finland, Norway, Sweden, Denmark, Russian Kola, Russian Karelia, Scotland and Wales

    Energy Technology Data Exchange (ETDEWEB)

    Henriksen, Arne; Skjelkvaale, Brit Lisa [Norsk Inst. for Vannforskning, Oslo (Norway); Mannio, Jaakko [FEI, (Finland)] [and others

    1997-12-31

    Beginning in 1995, national lake surveys were conducted in the above North European countries. This report provides the first united evaluation of lake water chemistry in Northern Europe. It was found that, except for Denmark, the water was characterized by low ionic strength and had low content of nitrogen and phosphorus. In Finland, Norway, Sweden, Russian Kola and Karelia more than 50% of the lakes had low critical load (CL) values for sulphur acidity (S), while Scotland, Wales and Denmark had very few lakes with low CL for S. The highest percentage (27%) of lakes with exceedence of CL for S was found in Norway, while the values for Russian Kola, Sweden and Finland were 17%, 9% and 9%, respectively. In Scotland and Wales, critical loads for sulphur acidity were exceeded in 1% of the total lake population. For Denmark and Russian Karelia, too few lakes were sampled to give reliable estimates. This adds up to approximately 22000 lakes in Northern Europe where CL for S was exceeded. However, this number of lakes is a minimum as exceedence of CL for N was not included in the calculation due to lack of catchment data. 26 refs., 21 figs., 13 tabs.

  16. [Study on the immunogenicity and safety of recombinant B-subunit/whole cell cholera vaccine infused with antacids in healthy population at ages of 2-6 years].

    Science.gov (United States)

    Huang, T; Li, R C; Liu, D P

    2017-09-06

    Objective: To assess the immunogenicity and sa