WorldWideScience

Sample records for healthcare challenges opportunities

  1. Healthcare in the Anthropocene: Challenges and Opportunities.

    Science.gov (United States)

    Hancock, Trevor

    2016-01-01

    We are entering the Anthropocene. So large is our impact on the planet that Earth scientists suggest our presence will show up in the geologic record far into the future. The global ecological changes we are creating pose a threat to health not only from climate change but from pollution and ecotoxicity, ocean acidification, resource depletion and the loss of biodiversity that threatens a sixth "Great Extinction." These health threats will impose an added burden on the healthcare system, while the ecological changes will force it to adapt to the new realities. The healthcare system contributes to these changes. It is an energy and resource-intensive part of society that also produces large volumes of solid and liquid wastes and air pollutants, some of them quite toxic; the system has a large ecological footprint; yet, at the same time, the system has an ethical duty to do no harm, and thus should be a leader in the transition to a more ecologically sustainable and healthier future.

  2. Challenges and Opportunities in Scaling-Up Nutrition in Healthcare

    Directory of Open Access Journals (Sweden)

    Ian Darnton-Hill

    2015-01-01

    Full Text Available Healthcare continues to be in a state of flux; conventionally, this provides opportunities and challenges. The opportunities include technological breakthroughs, improved economies and increasing availability of healthcare. On the other hand, economic disparities are increasing and leading to differing accessibility to healthcare, including within affluent countries. Nutrition has received an increase in attention and resources in recent decades, a lot of it stimulated by the rise in obesity, type 2 diabetes mellitus and hypertension. An increase in ageing populations also has meant increased interest in nutrition-related chronic diseases. In many middle-income countries, there has been an increase in the double burden of malnutrition with undernourished children and overweight/obese parents and adolescents. In low-income countries, an increased evidence base has allowed scaling-up of interventions to address under-nutrition, both nutrition-specific and nutrition-sensitive interventions. Immediate barriers (institutional, structural and biological and longer-term barriers (staffing shortages where most needed and environmental impacts on health are discussed. Significant barriers remain for the near universal access to healthcare, especially for those who are socio-economically disadvantaged, geographically isolated, living in war zones or where environmental damage has taken place. However, these barriers are increasingly being recognized, and efforts are being made to address them. The paper aims to take a broad view that identifies and then comments on the many social, political and scientific factors affecting the achievement of improved nutrition through healthcare.

  3. Methodological challenges and analytic opportunities for modeling and interpreting Big Healthcare Data

    National Research Council Canada - National Science Library

    Ivo D Dinov

    2016-01-01

    .... In this article, we outline various big data challenges, opportunities, modeling methods and software techniques for blending complex healthcare data, advanced analytic tools, and distributed scientific computing...

  4. Deep learning for healthcare: review, opportunities and challenges.

    Science.gov (United States)

    Miotto, Riccardo; Wang, Fei; Wang, Shuang; Jiang, Xiaoqian; Dudley, Joel T

    2017-05-06

    Gaining knowledge and actionable insights from complex, high-dimensional and heterogeneous biomedical data remains a key challenge in transforming health care. Various types of data have been emerging in modern biomedical research, including electronic health records, imaging, -omics, sensor data and text, which are complex, heterogeneous, poorly annotated and generally unstructured. Traditional data mining and statistical learning approaches typically need to first perform feature engineering to obtain effective and more robust features from those data, and then build prediction or clustering models on top of them. There are lots of challenges on both steps in a scenario of complicated data and lacking of sufficient domain knowledge. The latest advances in deep learning technologies provide new effective paradigms to obtain end-to-end learning models from complex data. In this article, we review the recent literature on applying deep learning technologies to advance the health care domain. Based on the analyzed work, we suggest that deep learning approaches could be the vehicle for translating big biomedical data into improved human health. However, we also note limitations and needs for improved methods development and applications, especially in terms of ease-of-understanding for domain experts and citizen scientists. We discuss such challenges and suggest developing holistic and meaningful interpretable architectures to bridge deep learning models and human interpretability. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  5. Crowdsourcing healthcare costs: Opportunities and challenges for patient centered price transparency.

    Science.gov (United States)

    Meisel, Zachary F; VonHoltz, Lauren A Houdek; Merchant, Raina M

    2016-03-01

    Efforts to improve health care price transparency have garnered significant attention from patients, policy makers, and health insurers. In response to increasing consumer demand, state governments, insurance plans, and health care providers are reporting health care prices. However, such data often do not provide consumers with the most salient information: their own actual out-of-pocket cost for medical care. Although untested, crowdsourcing, a mechanism for the public to help answer complex questions, represents a potential solution to the problem of opaque hospital costs. This article explores, the challenges and potential opportunities for crowdsourcing out-of-pocket costs for healthcare consumers. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Role of in-situ simulation for training in healthcare: opportunities and challenges.

    Science.gov (United States)

    Kurup, Viji; Matei, Veronica; Ray, Jessica

    2017-12-01

    Simulation has now been acknowledged as an important part of training in healthcare, and most academic hospitals have a dedicated simulation center. In-situ simulation occurs in patient care units with scenarios involving healthcare professionals in their actual working environment. The purpose of this review is to describe the process of putting together the components of in-situ simulation for training programs and to review outcomes studied, and challenges with this approach. In-situ simulation has been used to 'test-drive' new centers, train personnel in new procedures in existing centers, for recertification training and to uncover latent threats in clinical care areas. It has also emerged as an attractive alternative to traditional simulations for institutions that do not have their own simulation center. In-situ simulation can be used to improve reliability and safety especially in areas of high risk, and in high-stress environments. It is also a reasonable and attractive alternative for programs that want to conduct interdisciplinary simulations for their trainees and faculty, and for those who do not have access to a fully functional simulation center. Further research needs to be done in assessing effectiveness of training using this method and the effect of such training on clinical outcomes.

  7. Collaboration and Co-Production of Knowledge in Healthcare: Opportunities and Challenges

    Directory of Open Access Journals (Sweden)

    Jo Rycroft-Malone

    2016-04-01

    Full Text Available Over time there has been a shift, at least in the rhetoric, from a pipeline conceptualisation of knowledge implementation, to one that recognises the potential of more collaboration, co-productive approaches to knowledge production and use. In this editorial, which is grounded in our research and collective experience, we highlight both the potential and challenge with collaboration and co-production. This includes issues about stakeholder engagement, governance arrangements, and capacity and capability for working in a coproductive way. Finally, we reflect on the fact that this approach is not a panacea, but is accompanied by some philosophical and practical challenges.

  8. Dis-integration of communication in healthcare education: Workplace learning challenges and opportunities.

    Science.gov (United States)

    Rosenbaum, Marcy E

    2017-11-01

    The purpose of this paper, based on a 2016 Heidelberg International Conference on Communication in Healthcare (ICCH) plenary presentation, is to examine a key problem in communication skills training for health professional learners. Studies have pointed to a decline in medical students' communication skills and attitudes as they proceed through their education, particularly during their clinical workplace training experiences. This paper explores some of the key factors in this disintegration, drawing on selected literature and highlighting some curriculum efforts and research conducted at the University of Iowa Carver College of Medicine as a case study of these issues. Five key factors contributing to the disintegration of communication skills and attitudes are presented including: 1) lack of formal communication skills training during clinical clerkships; 2) informal workplace teaching failing to explicitly address learner clinical communication skills; 3) emphasizing content over process in relation to clinician-patient interactions; 4) the relationship between ideal communication models and the realities of clinical practice; and 5) clinical teachers' lack of knowledge and skills to effectively teach about communication in the clinical workplace. Within this discussion, potential practical responses by individual clinical teachers and broader curricular and faculty development efforts to address each of these factors are presented. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Missed opportunities in child healthcare

    Directory of Open Access Journals (Sweden)

    Linda Jonker

    2014-01-01

    Full Text Available Background: Various policies in health, such as Integrated Management of Childhood Illnesses, were introduced to enhance integrated service delivery in child healthcare. During clinical practice the researcher observed that integrated services may not be rendered.Objectives: This article describes the experiences of mothers that utilised comprehensive child health services in the Cape Metropolitan area of South Africa. Services included treatment for diseases; preventative interventions such as immunisation; and promotive interventions, such as improvement in nutrition and promotion of breastfeeding.Method: A qualitative, descriptive phenomenological approach was applied to explore the experiences and perceptions of mothers and/or carers utilising child healthcare services. Thirty percent of the clinics were selected purposively from the total population. A convenience purposive non-probability sampling method was applied to select 17 mothers who met the criteria and gave written consent. Interviews were conducted and recorded digitally using an interview guide. The data analysis was done using Tesch’s eight step model.Results: Findings of the study indicated varied experiences. Not all mothers received information about the Road to Health book or card. According to the mothers, integrated child healthcare services were not practised. The consequences were missed opportunities in immunisation, provision of vitamin A, absence of growth monitoring, feeding assessment and provision of nutritional advice.Conclusion: There is a need for simple interventions such as oral rehydration, early recognition and treatment of diseases, immunisation, growth monitoring and appropriate nutrition advice. These services were not offered diligently. Such interventions could contribute to reducing the incidence of child morbidity and mortality.

  10. Engineering ethics challenges and opportunities

    CERN Document Server

    Bowen, W Richard

    2014-01-01

    Engineering Ethics: Challenges and Opportunities aims to set a new agenda for the engineering profession by developing a key challenge: can the great technical innovation of engineering be matched by a corresponding innovation in the acceptance and expression of ethical responsibility?  Central features of this stimulating text include:   ·         An analysis of engineering as a technical and ethical practice providing great opportunities for promoting the wellbeing and agency of individuals and communities. ·         Elucidation of the ethical opportunities of engineering in three key areas:             - Engineering for Peace, emphasising practical amelioration of the root causes of    conflict rather than military solutions.             - Engineering for Health, focusing on close collaboration with healthcare professionals      for both the promotion and restoration of health.             - Engineering for Development, providing effective solution...

  11. DIGITAL PAKISTAN: OPPORTUNITIES & CHALLENGES

    Directory of Open Access Journals (Sweden)

    Ghulam Muhammad Kundi

    2008-10-01

    Full Text Available IT has revolutionized the social and organizational life around the globe. Given the newness of IT as a technology, there is a lot of potential that needs to be explored. It is however, argued that as IT can revolutionize the economic development, by the same coin, although its mismanagement in adoption process can end up in problems or even straight failure of the technology at the business-end. This study was conducted with reference to opportunities and challenges in the IT adoption process in Pakistan. The aim of the study was to point out the barriers that are impeding the country’s computerization process in order to provide facts to the policy makers for smooth computerization. The primary data collected through structured questionnaires was analyzed and tested through correlation, regressions analysis and t-test. Out of 10 hypotheses, 3 were accepted while in the rest null hypotheses were not substantiated. Based on primary and secondary data analysis this study has found that all independent bureaucratic, political, education and social and cultural variables are mutually correlated and have significant impact on shaping and reshaping of IT in Pakistan, while the Pakistan IT policy is inconsistent, administrative machinery attitude is negative and non cooperative, procedures are cumbersome and implementation is weak and ineffective, not to mention the lack of IT knowledge on the bureaucratic side. The political environment is instable and law and order is worse which is discouraging the investment. Moreover, physical and legal infrastructure is insufficient and the country is lacking good quality IT professionals. IT organization alignment is another serious issue in Pakistan. However, government incentives and growing interest from the private sector indicate positive attitude towards computerization of the country.

  12. Measuring healthcare quality: the challenges.

    Science.gov (United States)

    van den Heuvel, Jaap; Niemeijer, Gerard C; Does, Ronald J M M

    2013-01-01

    Current health care quality performance indicators appear to be inadequate to inform the public to make the right choices. The aim of this paper is to define a framework and an organizational setting in which valid and reliable healthcare information can be produced to inform the general public about healthcare quality. To improve health care quality information, the paper explores the analogy between financial accounting, which aims to produce valid and reliable information to support companies informing their shareholders and stakeholders, and healthcare aiming to inform future patients about healthcare quality. Based on this analogy, the authors suggest a measurement framework and an organizational setting to produce healthcare information. The authors suggest a five-quality element framework to structure quality reporting. The authors also indicate the best way to report each type of quality, comparing performance indicators with certification/accreditation. Health gain is the most relevant quality indicator to inform the public, but this information is the most difficult to obtain. Finally, the organizational setting, comparable to financial accounting, required to provide valid, reliable and objective information on healthcare quality is described. Framework elements should be tested in quantitative studies or case studies, such as a performance indicator's relative value compared to accreditation/certification. There are, however, elements that can be implemented right away such as third party validation of healthcare information produced by healthcare institutions. Given the money spent on healthcare worldwide, valid and reliable healthcare quality information's value can never be overestimated. It can justify delivering "expensive healthcare, but also points the way to savings by stopping useless healthcare. Valid and reliable information puts the patient in the driver's seat and enables him or her to make the right decision when choosing their healthcare

  13. Challenges and opportunities for REDD+

    DEFF Research Database (Denmark)

    Pasgaard, Maya; Sun, Zhanli; Müller, Daniel

    2016-01-01

    Reducing Emissions from Deforestation and forest Degradation (REDD+) is a promising mechanism of payments for ecosystem services with the aim to effectively reduce emissions in an efficient and equitable manner. REDD+ is part of the Paris-agreement reached at the UNFCCC COP21 in December 2015...... the opportunities and challenges of REDD+ for achieving effective, efficient and equitable outcomes and co-benefits (3E+). We substantiate our survey results with a literature review. Results suggest that the challenges in achieving the 3E+ relate to the disproportionality between deforestation drivers...

  14. Interprofessional Education: Opportunities and Challenges for Psychology.

    Science.gov (United States)

    Ward, Wendy; Zagoloff, Alexandra; Rieck, Cortney; Robiner, William

    2018-02-16

    This manuscript is an outgrowth of an invited panel presentation at the national Association for Psychologists in Academic Health Centers Conference in 2017 on Interprofessional Education (IPE). IPE is a structured and transformative educational strategy designed to provide active learning experiences where trainees from diverse healthcare professions gain shared content knowledge plus collaboration skills as they learn about, from, and with each other. Collaboration skills include understanding professional role distinctions and overlap, effective team-based communication, shared values/ethics and respect for each other's expertise, and teamwork dynamics. It is increasingly important to expand training beyond the intraprofessional activities in which psychology trainees engage to prepare them to participate in interprofessional collaborative care. As healthcare systems move to team-based collaborative practice and value-based reimbursement models, the profession of psychology needs leaders at every academic health center to facilitate the design and/or implementation of IPE activities. The panel of psychologists presented roles that psychologists play in IPE institutional program design and implementation, graduate training programs, and the perspectives of an early career psychologist and psychology trainee. Opportunities and challenges are highlighted, culminating in a call to action. Psychologists must embrace their identity as health professionals and engage their learners in IPE so that the emerging cognitive schemata of healthcare that is developed includes the profession of psychology. Otherwise, healthcare teams and health professionals will not understand the value, roles, or potential contributions of psychologists in enhancing patient care outcomes, ultimately jeopardizing psychologists' referrals, involvement in healthcare delivery, and career opportunities.

  15. Rural Entrepreneurship: Challenges and Opportunities

    OpenAIRE

    Imedashvili, Sopiko; Kekua, Ani; Ivchenko, Polina

    2013-01-01

    According to World Bank Report published in 2012, the rural population in Sweden is 15.3 %. Rural population is calculated as difference between total populations minus urban population. 15.3 % clearly shows how important rural areas are for Sweden’s future development. Entrepreneurship plays the integral role in rural area development. However, earlier research has shown only economic perspective of rural development. On the other hand, the new ways to discover the challenges and opportuniti...

  16. Polymer Informatics: Opportunities and Challenges.

    Science.gov (United States)

    Audus, Debra J; de Pablo, Juan J

    2017-10-01

    We are entering an era where large volumes of scientific data, coupled with algorithmic and computational advances, can reduce both the time and cost of developing new materials. This emerging field known as materials informatics has gained acceptance for a number of classes of materials, including metals and oxides. In the particular case of polymer science, however, there are important challenges that must be addressed before one can start to deploy advanced machine learning approaches for designing new materials. These challenges are primarily related to the manner in which polymeric systems and their properties are reported. In this viewpoint, we discuss the opportunities and challenges for making materials informatics as applied to polymers, or equivalently polymer informatics, a reality.

  17. Multiphysics simulations: challenges and opportunities.

    Energy Technology Data Exchange (ETDEWEB)

    Keyes, D.; McInnes, L. C.; Woodward, C.; Gropp, W.; Myra, E.; Pernice, M. (Mathematics and Computer Science); (KAUST and Columbia Univ.); (Lawrence Livermore National Laboratory); (Univ. of Illinois at Urbana-Champaign); (Univ. of Mich.); (Idaho National Lab.)

    2012-11-29

    This report is an outcome of the workshop Multiphysics Simulations: Challenges and Opportunities, sponsored by the Institute of Computing in Science (ICiS). Additional information about the workshop, including relevant reading and presentations on multiphysics issues in applications, algorithms, and software, is available via https://sites.google.com/site/icismultiphysics2011/. We consider multiphysics applications from algorithmic and architectural perspectives, where 'algorithmic' includes both mathematical analysis and computational complexity and 'architectural' includes both software and hardware environments. Many diverse multiphysics applications can be reduced, en route to their computational simulation, to a common algebraic coupling paradigm. Mathematical analysis of multiphysics coupling in this form is not always practical for realistic applications, but model problems representative of applications discussed herein can provide insight. A variety of software frameworks for multiphysics applications have been constructed and refined within disciplinary communities and executed on leading-edge computer systems. We examine several of these, expose some commonalities among them, and attempt to extrapolate best practices to future systems. From our study, we summarize challenges and forecast opportunities. We also initiate a modest suite of test problems encompassing features present in many applications.

  18. Measuring healthcare quality: the challenges

    NARCIS (Netherlands)

    van den Heuvel, J.; Niemeijer, G.C.; Does, R.J.M.M.

    2013-01-01

    Purpose - Current health care quality performance indicators appear to be inadequate to inform the public to make the right choices. The aim of this paper is to define a framework and an organizational setting in which valid and reliable healthcare information can be produced to inform the general

  19. Multiphysics simulations: Challenges and opportunities

    KAUST Repository

    Keyes, David E.

    2013-02-01

    We consider multiphysics applications from algorithmic and architectural perspectives, where "algorithmic" includes both mathematical analysis and computational complexity, and "architectural" includes both software and hardware environments. Many diverse multiphysics applications can be reduced, en route to their computational simulation, to a common algebraic coupling paradigm. Mathematical analysis of multiphysics coupling in this form is not always practical for realistic applications, but model problems representative of applications discussed herein can provide insight. A variety of software frameworks for multiphysics applications have been constructed and refined within disciplinary communities and executed on leading-edge computer systems. We examine several of these, expose some commonalities among them, and attempt to extrapolate best practices to future systems. From our study, we summarize challenges and forecast opportunities. © The Author(s) 2012.

  20. Multiphysics Simulations: Challenges and Opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Keyes, David; McInnes, Lois C.; Woodward, Carol; Gropp, William; Myra, Eric; Pernice, Michael; Bell, John; Brown, Jed; Clo, Alain; Connors, Jeffrey; Constantinescu, Emil; Estep, Don; Evans, Kate; Farhat, Charbel; Hakim, Ammar; Hammond, Glenn E.; Hansen, Glen; Hill, Judith; Isaac, Tobin; Jiao, Xiangmin; Jordan, Kirk; Kaushik, Dinesh; Kaxiras, Efthimios; Koniges, Alice; Lee, Ki Hwan; Lott, Aaron; Lu, Qiming; Magerlein, John; Maxwell, Reed M.; McCourt, Michael; Mehl, Miriam; Pawlowski, Roger; Randles, Amanda; Reynolds, Daniel; Riviere, Beatrice; Rude, Ulrich; Scheibe, Timothy D.; Shadid, John; Sheehan, Brendan; Shephard, Mark; Siegel, Andrew; Smith, Barry; Tang, Xianzhu; Wilson, Cian; Wohlmuth, Barbara

    2013-02-12

    We consider multiphysics applications from algorithmic and architectural perspectives, where ‘‘algorithmic’’ includes both mathematical analysis and computational complexity, and ‘‘architectural’’ includes both software and hardware environments. Many diverse multiphysics applications can be reduced, en route to their computational simulation, to a common algebraic coupling paradigm. Mathematical analysis of multiphysics coupling in this form is not always practical for realistic applications, but model problems representative of applications discussed herein can provide insight. A variety of software frameworks for multiphysics applications have been constructed and refined within disciplinary communities and executed on leading-edge computer systems. We examine several of these, expose some commonalities among them, and attempt to extrapolate best practices to future systems. From our study, we summarize challenges and forecast opportunities.

  1. Challenges and opportunities in presbycusis.

    Science.gov (United States)

    Parham, Kourosh; McKinnon, Brian J; Eibling, David; Gates, George A

    2011-04-01

    The population aged 65 years and older is increasing at a faster rate than the total population, with predictions that by 2030, 20% of the population will be 65 years or older. In 2006, between 35% and 50% of those aged 65 years or older reportedly had presbycusis, a sensory impairment that contributes to social isolation and loss of autonomy and is associated with anxiety, depression, and cognitive decline. To address these concerns, the Geriatric Committee of the American Academy of Otolaryngology, in conjunction with the Hearing Committee, focused on 3 challenges and opportunities in the management of presbycusis: (1) the financial burden of caring for patients with presbycusis in the face of increasing costs and declining reimbursements; (2) future treatment options arising from improved understanding of the molecular mechanisms underlying presbycusis, and (3) recognition of central presbycusis as a condition commonly superimposed on peripheral age-related hearing loss whose diagnosis and management can improve outcomes.

  2. Green ergonomics: challenges and opportunities.

    Science.gov (United States)

    Hanson, Margaret A

    2013-01-01

    Addressing the causes and consequences of environmental degradation presents significant challenges for humankind. This paper considers what ergonomics/human factors (E/HF) professionals can contribute to understanding and tackling some of the issues that arise through the movement towards a more environmentally sustainable economy. These issues are considered in relation to work in green industries (specifically, sustainable energy production, recycling and organic food production), and there is a need to ensure that these jobs are safe and healthy; the design of products and systems that are 'environmentally friendly' to facilitate their acceptability and use and how E/HF professionals can contribute to understanding and promoting behavioural change relating to environmental choices. The activities of some international organisations in this area are identified and the potential for E/HF involvement is considered. The implications for the E/HF profession are discussed. This paper considers how ergonomics/human factors professionals can contribute to the movement towards more sustainable and 'environmentally friendly' design and work. Potential challenges and opportunities are discussed in relation to jobs in green industries, products and systems and behaviour change.

  3. Cooperative Projects - Challenges and Opportunities

    Science.gov (United States)

    Schubotz, Wiebke; Brücher, Tim; Vamborg, Freja

    2017-04-01

    Today's research in Germany is often organized in large projects and collaborations, so-called cooperative projects ("Verbundprojekte" in German). These projects are defined by a large number of members (more than 50) and participating institutes, e.g. institutes of research organizations such as the Max-Planck society and the Leibniz association, Helmholtz centres, and universities. For coordination purposes these projects usually have a general project manager or project coordinator close to the speaker of the project. Despite this overarching position, it is often challenging for the project manager to really overview the entire project as he is, for example, not involved in the individual institute's recruitment processes or research connections to other institutes via other projects. Additionally, there is neither a formal obligation for the principal investigators and project scientists to report changes within their sub-projects, nor any formal dependency between these sub-projects and the coordination office to ensure a contemporary update of changes and progress in their specific tasks of the project. Therefore, the idea of a coordinating position to oversee the entire cooperative project is sometimes difficult to reach. Furthermore, project managers usually have no formal connection to other project managers. This means that recurrent tasks, for which cooperation between project managers would be helpful, need to be reinvented for each project anew. Due to the lack of this more formalized cooperation between project managers, acquired expertise is often lost. We will illustrate the challenges of this kind of project management based on projects at the Max Planck Institute for Meteorology (Hamburg) and the Helmholtz Centre for Ocean Research (GEOMAR, Kiel), but also point out opportunities that arise within a large collaboration of partners. Moreover, we present an approach to coordinate management processes in order to overcome some of the aforementioned

  4. Challenges for delivering healthcare education through telematics.

    Science.gov (United States)

    Alpay, L; Murray, P

    1998-06-01

    Within the context of the education of professional healthcare providers, the authors give an overview of the challenges faced by those wishing to introduce telematics as both a mechanism for content delivery and as subject content itself. After presenting a brief overview of the current state of telematics applications to healthcare education, focusing on the European sphere, the authors outline the challenges before discussing the collaborative and communicative issues in detail. The authors conclude by suggesting that, while the authors believe that telematics is a necessary direction for the future development of healthcare education for professionals, the collaboration and communication challenges are of greater importance than the technical and policy challenges and that there is a need to educate the majority of educators, based in the experiences of the enthusiasts.

  5. Clinical Bioinformatics: challenges and opportunities.

    Science.gov (United States)

    Bellazzi, Riccardo; Masseroli, Marco; Murphy, Shawn; Shabo, Amnon; Romano, Paolo

    2012-01-01

    Network Tools and Applications in Biology (NETTAB) Workshops are a series of meetings focused on the most promising and innovative ICT tools and to their usefulness in Bioinformatics. The NETTAB 2011 workshop, held in Pavia, Italy, in October 2011 was aimed at presenting some of the most relevant methods, tools and infrastructures that are nowadays available for Clinical Bioinformatics (CBI), the research field that deals with clinical applications of bioinformatics. In this editorial, the viewpoints and opinions of three world CBI leaders, who have been invited to participate in a panel discussion of the NETTAB workshop on the next challenges and future opportunities of this field, are reported. These include the development of data warehouses and ICT infrastructures for data sharing, the definition of standards for sharing phenotypic data and the implementation of novel tools to implement efficient search computing solutions. Some of the most important design features of a CBI-ICT infrastructure are presented, including data warehousing, modularity and flexibility, open-source development, semantic interoperability, integrated search and retrieval of -omics information. Clinical Bioinformatics goals are ambitious. Many factors, including the availability of high-throughput "-omics" technologies and equipment, the widespread availability of clinical data warehouses and the noteworthy increase in data storage and computational power of the most recent ICT systems, justify research and efforts in this domain, which promises to be a crucial leveraging factor for biomedical research.

  6. Tuberculosis diagnostics: Challenges and opportunities

    Directory of Open Access Journals (Sweden)

    Vijay Nema

    2012-01-01

    Full Text Available Tuberculosis (TB has been a disease affecting almost all parts of the world since ages. Lot many efforts came in the past for improving diagnosis and treatment. Also, an effective vaccine has been sought after for long. With the emergence of resistant strains of Mycobacterium tuberculosis, the causal organisms of tuberculosis, and complexities emerging due to other associated infections and disease conditions, there is a desperate need for further research input in the field. Be it the better medication and care or better resistance management, proper diagnostics holds the key to success. It has been observed that a high burden of the disease was accompanied by resource limitations and poor research set-up. The scenario remained like this for several decades. With the refreshed vision of resourceful countries and funding agencies, funding is being provided in many areas of research in tuberculosis diagnosis and treatment. This review has been written with an aim to bring forth the limitations of available methods in the field of diagnostics and making researchers aware about the changing scenario with better funding opportunities and support. The author visualizes an enthusiasm from all over the world for the development of better modalities and urges scientists to join the struggle at this very perfect time to take the challenge and come forward with innovations in this field.

  7. Challenges and Opportunities for Libraries in Pakistan

    OpenAIRE

    Shafiq Ur, Rehman; Pervaiz, Ahmad

    2007-01-01

    Abstract: This paper, based on review of literature, observation, and informal conversations, discusses various challenges regarding finance, collection development, ICTs, human resources, library education, library association and research & development faced by library profession in Pakistan. The opportunities to meet these challenges have also been explored. Keywords: Library challenges and opportunities (Pakistan); Librarianship (Pakistan); Library issues; Library profession in Pa...

  8. Challenges of Data-driven Healthcare Management

    DEFF Research Database (Denmark)

    Bossen, Claus; Danholt, Peter; Ubbesen, Morten Bonde

    This paper describes the new kind of data-work involved in developing data-driven healthcare based on two cases from Denmark: The first case concerns a governance infrastructure based on Diagnose-Related Groups (DRG), which was introduced in Denmark in the 1990s. The DRG-system links healthcare....... Here, a core challenge is select indicators and actually being able to acquire data upon them. The two cases point out that data-driven healthcare requires more and new kinds of work for which new skills, functions and work roles have to be developed....... activity and financing and relies of extensive data entry, reporting and calculations. This has required the development of new skills, work and work roles. The second case concerns a New Governance project aimed at developing new performance indicators for healthcare delivery as an alternative to DRG...

  9. Neurogenomics: Challenges and opportunities for Ghana

    Directory of Open Access Journals (Sweden)

    Thomas K. Karikari

    2015-06-01

    Full Text Available The application of genomic tools and technologies has shown the potential to help improve healthcare and our understanding of disease mechanisms. While genomic tools are increasingly being applied to research on infectious diseases, malaria and neglected tropical diseases in Africa, an area that has seen little application of genomic approaches on this continent is neuroscience. In this article, we examined the prospects of developing neurogenomics research and its clinical use in Ghana, one of the African countries actively involved in genomics research. We noted that established international research funding sources and foundations in genomic research such as H3ABioNet nodes established at a couple of research centres in Ghana provide excellent platforms for extending the usage of genomic tools and techniques to neuroscience-related research areas. However, existing challenges such as the (i lack of degree programmes in neuroscience, genomics and bioinformatics; (ii low availability of infrastructure and appropriately-trained scientists; and (iii lack of local research funding opportunities, need to be addressed. To promote and safeguard the long-term sustainability of neurogenomics research in the country, the impact of the existing challenges and possible ways of addressing them have been discussed.

  10. Future landscapes: opportunities and challenges

    Science.gov (United States)

    John Stanturf

    2015-01-01

    The global magnitude of degraded and deforested areas is best approached by restoring landscapes. Heightened international perception of the importance of forests and trees outside forests (e.g., woodlands, on farms) demands new approaches to future landscapes. The current need for forest restoration is two billion ha; most opportunities are mosaic restoration in the...

  11. Presidential Transition. Challenges and Opportunities

    National Research Council Canada - National Science Library

    Walker, David

    2000-01-01

    .... Attention to these themes will help the new administration successfully implement its agenda and address both long-standing and newly emerging management, fiscal, and other challenges that confront...

  12. Flexible SERS Substrates: Challenges and Opportunities

    Science.gov (United States)

    2016-01-28

    photochemistry of three types of molecules isolated in alkanethiolate SAMs: the photoisomerization of azobenzene , the photo-isomerization of dihydroazulene...and the photoreaction of anthracene derivatives . The opportunities and challenges of employing flexible SERS substrates to further improve these

  13. Smart textiles: Challenges and opportunities

    Science.gov (United States)

    Cherenack, Kunigunde; van Pieterson, Liesbeth

    2012-11-01

    Smart textiles research represents a new model for generating creative and novel solutions for integrating electronics into unusual environments and will result in new discoveries that push the boundaries of science forward. A key driver for smart textiles research is the fact that both textile and electronics fabrication processes are capable of functionalizing large-area surfaces at very high speeds. In this article we review the history of smart textiles development, introducing the main trends and technological challenges faced in this field. Then, we identify key challenges that are the focus of ongoing research. We then proceed to discuss fundamentals of smart textiles: textile fabrication methods and textile interconnect lines, textile sensor, and output device components and integration of commercial components into textile architectures. Next we discuss representative smart textile systems and finally provide our outlook over the field and a prediction for the future.

  14. Plastics recycling: challenges and opportunities.

    Science.gov (United States)

    Hopewell, Jefferson; Dvorak, Robert; Kosior, Edward

    2009-07-27

    Plastics are inexpensive, lightweight and durable materials, which can readily be moulded into a variety of products that find use in a wide range of applications. As a consequence, the production of plastics has increased markedly over the last 60 years. However, current levels of their usage and disposal generate several environmental problems. Around 4 per cent of world oil and gas production, a non-renewable resource, is used as feedstock for plastics and a further 3-4% is expended to provide energy for their manufacture. A major portion of plastic produced each year is used to make disposable items of packaging or other short-lived products that are discarded within a year of manufacture. These two observations alone indicate that our current use of plastics is not sustainable. In addition, because of the durability of the polymers involved, substantial quantities of discarded end-of-life plastics are accumulating as debris in landfills and in natural habitats worldwide. Recycling is one of the most important actions currently available to reduce these impacts and represents one of the most dynamic areas in the plastics industry today. Recycling provides opportunities to reduce oil usage, carbon dioxide emissions and the quantities of waste requiring disposal. Here, we briefly set recycling into context against other waste-reduction strategies, namely reduction in material use through downgauging or product reuse, the use of alternative biodegradable materials and energy recovery as fuel. While plastics have been recycled since the 1970s, the quantities that are recycled vary geographically, according to plastic type and application. Recycling of packaging materials has seen rapid expansion over the last decades in a number of countries. Advances in technologies and systems for the collection, sorting and reprocessing of recyclable plastics are creating new opportunities for recycling, and with the combined actions of the public, industry and governments it

  15. Plastics recycling: challenges and opportunities

    Science.gov (United States)

    Hopewell, Jefferson; Dvorak, Robert; Kosior, Edward

    2009-01-01

    Plastics are inexpensive, lightweight and durable materials, which can readily be moulded into a variety of products that find use in a wide range of applications. As a consequence, the production of plastics has increased markedly over the last 60 years. However, current levels of their usage and disposal generate several environmental problems. Around 4 per cent of world oil and gas production, a non-renewable resource, is used as feedstock for plastics and a further 3–4% is expended to provide energy for their manufacture. A major portion of plastic produced each year is used to make disposable items of packaging or other short-lived products that are discarded within a year of manufacture. These two observations alone indicate that our current use of plastics is not sustainable. In addition, because of the durability of the polymers involved, substantial quantities of discarded end-of-life plastics are accumulating as debris in landfills and in natural habitats worldwide. Recycling is one of the most important actions currently available to reduce these impacts and represents one of the most dynamic areas in the plastics industry today. Recycling provides opportunities to reduce oil usage, carbon dioxide emissions and the quantities of waste requiring disposal. Here, we briefly set recycling into context against other waste-reduction strategies, namely reduction in material use through downgauging or product reuse, the use of alternative biodegradable materials and energy recovery as fuel. While plastics have been recycled since the 1970s, the quantities that are recycled vary geographically, according to plastic type and application. Recycling of packaging materials has seen rapid expansion over the last decades in a number of countries. Advances in technologies and systems for the collection, sorting and reprocessing of recyclable plastics are creating new opportunities for recycling, and with the combined actions of the public, industry and governments it

  16. UAV imagery analysis: challenges and opportunities

    Science.gov (United States)

    Grant, Barbara G.

    2017-05-01

    As UAV imaging continues to expand, so too do the opportunities for improvements in data analysis. These opportunities, in turn, present their own challenges including the need for real time radiometric and spectral calibration; the continued development of quality metrics facilitating exploitation of strategic and tactical imagery; and the need to correct for sensor and platform-induced artifacts in image data.

  17. Quantum Information: Opportunities and Challenges

    Energy Technology Data Exchange (ETDEWEB)

    Bennink, Ryan S [ORNL

    2008-01-01

    Modern society is shaped by the ability to transmit, manipulate, and store large amounts of information. Although we tend to think of information as abstract, information is physical, and computing is a physical process. How then should we understand information in a quantum world, in which physical systems may exist in multiple states at once and are altered by the very act of observation? This question has evolved into an exciting new field of research called Quantum Information (QI). QI challenges many accepted rules and practices in computer science. For example, a quantum computer would turn certain hard problems into soft problems, and would render common computationally-secure encryption methods (such as RSA) insecure. At the same time, quantum communication would provide an unprecedented kind of intrinsic information security at the level of the smallest physical objects used to store or transmit the information. This talk provides a general introduction to the subject of quantum information and its relevance to cyber security. In the first part, two of the stranger aspects of quantum physics namely, superposition and uncertainty are explained, along with their relation to the concept of information. These ideas are illustrated with a few examples: quantum ID cards, quantum key distribution, and Grover s quantum search algorithm. The state-of-the-art in quantum computing and communication hardware is then discussed, along with the daunting technological challenges that must be overcome. Relevant experimental and theoretical efforts at ORNL are highlighted. The talk concludes with speculations on the short- and long-term impact of quantum information on cyber security.

  18. Healthcare Policy in Romania. Frameworks and Challenges

    Directory of Open Access Journals (Sweden)

    Buţiu Călina Ana

    2016-07-01

    Full Text Available The objective of the paper is to review some of the healthcare policy issues of Romania and identify those challenges which may be addressed through social intervention. Based on statistical data, documents, reports and applicable laws one will review the health condition of Romanian population and the state of the national health system, and will examine the broad strategies and policies currently under the scrutiny of appropriate ministries. The findings of the study suggest looking at health policies also through the lens of social inclusion.

  19. New context and old challenges in the healthcare system.

    Science.gov (United States)

    Peiró, Manel; Barrubés, Joan

    2012-07-01

    The economic crisis cannot conceal the need for transformation of the National Health System. The financial difficulties of healthcare systems whose spending is growing at a faster rate than the economy have been well known for years. The development and diffusion of new technologies, increased use of health services, rising drug costs, inflation of prices, and the inefficiency of the system explain the new context. The challenges facing the healthcare system are not new: address the debt, improve funding, review the list of services, transform the governance of the system and provide the institutions with real management autonomy. The gravity of the economic situation can be an opportunity to carry out the long-awaited changes. Copyright © 2012 Sociedad Española de Cardiología. Published by Elsevier Espana. All rights reserved.

  20. e-Health Cloud: Opportunities and Challenges

    Directory of Open Access Journals (Sweden)

    Jameela Al-Jaroodi

    2012-07-01

    Full Text Available As the costs of healthcare services rise and healthcare professionals are becoming scarce and hard to find, it is imminent that healthcare organizations consider adopting health information technology (HIT systems. HIT allows health organizations to streamline many of their processes and provide services in a more efficient and cost-effective manner. The latest technological trends such as Cloud Computing (CC provide a strong infrastructure and offer a true enabler for HIT services over the Internet. This can be achieved on a pay-as-you-use model of the “e-Health Cloud” to help the healthcare industry cope with current and future demands yet keeping their costs to a minimum. Despite its great potential, HIT as a CC model has not been addressed extensively in the literature. There are no apparent frameworks which clearly encompass all viable schemes and interrelationships between HIT and CC. Therefore, analyzing and comparing the effectiveness of such schemes is important. In this paper we introduce the concept of “e-Health Cloud” highlighting many of its constituents and proposing building an e-health environment and elucidating many of the challenges confronting the success of the e-Health Cloud. We will also discuss different possible solutions to address challenges such as security and privacy.

  1. India's demographic change: opportunities and challenges.

    Science.gov (United States)

    James, K S

    2011-07-29

    This paper discusses emerging demographic patterns and its opportunities and challenges for India. It investigates the specificities in the demographic transition in terms of various demographic parameters and the lack of homogeneity in the transition across states in the country. It presents some opportunities that can arise from having demographic changes, particularly the demographic dividend and interstate migration to overcome labor shortage in some parts. At the same time, there are serious challenges in the form of enhancing human capital development, addressing the issue of skewed sex ratio, and the possible rise in social and political unrest and conflict.

  2. Challenges, opportunities and achievements of nurses' research ...

    African Journals Online (AJOL)

    Nurse educators and researches are calling for national and international nursing education research to align resources within and outside the discipline, ... This paper explores the challenges, opportunities and achievements that nursing students face when supervised across culture, language borders and distance.

  3. Challenges and opportunities for dietary campaigns

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino; Aschemann-Witzel, Jessica; Verbeke, Wim

    2013-01-01

    The objective of our research was to explore and discuss the challenges and opportunities inherent to the management of public healthy eating campaigns. The discussion is based on a study of campaign managers’ perceptions of nine successfully implemented European healthy eating campaigns. Based...... influence the targets, the development of credible and emotive messages and relationships with media and public institutions....

  4. Community Languages in Europe : Challenges and Opportunities

    NARCIS (Netherlands)

    McPake, J.; Martyniuk, W.; Aarts, R.; Broeder, Peter; Latomaa, Sirkku; Mijares, Laura; Tinsley, Teresa

    2004-01-01

    This paper reviews issues affecting school students’ learning of community languages across Europe, with the aim of identifying both challenges and opportunities inherent in the current context. Language education pol icy has become more inclusive of late, addressing the full range of languages

  5. Towards Quality Art Education: Challenges and Opportunities ...

    African Journals Online (AJOL)

    ... and government, social identity, lack of facilities and materials, among others. Recommendations were proffered on the way forward. The paper finally concludes that good quality art education is an essential component of holistic education (formal and informal). Keywords: quality, art education, challenges, opportunities ...

  6. Active ageing in Pakistan: challenges and opportunities.

    Science.gov (United States)

    Vertejee, Samina Subzali; Karamali, Noureen Nasruddin

    2014-01-01

    The increasing number of ageing population is a signpost for re-directing the resources to ensure quality of life for elderly thus promoting active ageing. However, the challenges to achieve the goal outweigh the opportunities due to scarcity of resources. Several factors including, brain drain, poverty, lack of knowledge of elderly to protect their rights in association with poor state laws determines the poor quality of life for elderly in Pakistan. Although, the apparent scenario is quite unpleasant yet there are several opportunities such as improved crude birth and death rates, increased awareness about gerontology as a specialty care area and constitutions of Pakistan can be significant to ensure the well being of elderly and overcome the challenges to achieve active ageing in Pakistan. It is important to make best use of opportunities at hand by redirecting the resources to improve the quality of life to promote active ageing in Pakistan.

  7. Conducting international nursing research: challenges and opportunities.

    Science.gov (United States)

    Opollo, Jackline Gloria; Opollo, Diana Alaka; Gray, Jennifer; Spies, Lori

    2014-11-01

    To describe practical experiences before, during and after gaining entry into research fields in Kenya and Uganda. Planning, conducting and implementing international research can be an arduous task. Novice researchers need practical guides to accessing international fields and mitigating challenges met in the field. The researchers conducted three different studies in two developing nations. This paper reviews challenges encountered when conducting international research. Solutions used to overcome these challenges are discussed. Establishing and maintaining effective partnerships is critical to the success of international research efforts. Researchers must be tactful, flexible and creative when handling methodological, ethical and logistical challenges encountered in settings poor in resources. International research provides opportunities for increasing dedication, building cross-cultural competence and advancing health professional practice globally. This paper contributes to nursing scholarship by highlighting the practical challenges of conducting international research. Illustrations aimed at lending insight and encouraging others to expand their dedication to conducting international research are offered.

  8. Techno-Anthropological Sensibilities in Health Informatics: Opportunities and challenges.

    Science.gov (United States)

    Bossen, Claus

    2015-01-01

    What kind of knowledges, skills and competences may be required by Techno-Anthropology engaging with health informatics? If we understand Techno-Anthropology to mean conducting anthropological analyses of the interwoven and mutually shaping relationship between organizing, technologies and actors in healthcare, such engagements and interventions can take many forms: Short-term consultancy work dedicated to achieving specific goals, long-term studies of broad changes in healthcare; management support within hospitals and public healthcare administration; or technology development with vendors of healthcare IT. The opportunities would seem to be manifold. Since the healthcare sector is a heterogeneous mix of interests, political agendas, professions et cetera, there is great merit in having people knowledgeable about this heterogeneity; able to facilitate meetings and processes between the various professions and organizations; and skilled in generating analyses and proposing new solutions. Also, people with insight into how action, technologies and organizing are interwoven and redistribute competences, responsibilities and risks are invaluable: Look at from afar, technologies seem to cause and determine social development, whereas detailed studies reveal that determinants and causes are both technical and social. The challenges include the one of making one's knowledge and skills legitimate and relevant to health informatics. Having a degree from arts or social sciences is not necessarily impressive for people with similar degrees in medicine, computer science, and business administration. Another challenge is to design an engagement with health informatics that will generate insights which often requires time, while also providing quick results for project sponsors or collaborators. The chapter points at three issues that seem to be central foundations for appropriate and quality-driven research and interventions of the 'quick and proper' kind: Modes of engagement

  9. The medical leadership challenge in healthcare is an identity challenge.

    Science.gov (United States)

    Andersson, Thomas

    2015-01-01

    The purpose of this article is to describe and analyse the identity challenges that physicians with medical leadership positions face. Four qualitative case studies were performed to address the fact that identity is processual, relational and situational. Physicians with managerial roles were interviewed, as well as their peers, supervisors and subordinates. Furthermore, observations were made to understand how different identities are displayed in action. This study illustrates that medical leadership implies identity struggles when physicians have manager positions, because of the different characteristics of the social identities of managers and physicians. Major differences are related between physicians as autonomous individuals in a system and managers as subordinates to the organizational system. There are psychological mechanisms that evoke the physician identity more often than the managerial identity among physicians who are managers, which explains why physicians who are managers tend to remain foremost physicians. The implications of the findings, that there are major identity challenges by being both a physician and manager, suggest that managerial physicians might not be the best prerequisite for medical leadership, but instead, cooperative relationships between physicians and non-physician managers might be a less difficult way to support medical leadership. Acknowledging and addressing identity challenges can be important both in creating structures in organizations and designing the training for managers in healthcare (both physicians and non-physicians) to support medical leadership. Medical leadership is most often related to organizational structure and/or leadership skills, but this paper discusses identity requirements and challenges related to medical leadership.

  10. Innovation in healthcare. The challenge for laboratory medicine.

    Science.gov (United States)

    Price, Christopher P; St John, Andrew

    2014-01-01

    The delivery of healthcare is the product of a complex organization and it is not entirely surprising that innovation is not always considered to deliver on the expectations generated by invention. As policymakers and payers seek to improve the quality and value-for-money of healthcare, more attention is being directed at the barriers to innovation, and the challenges of translating inventions into outcomes. Laboratory medicine is one facet of healthcare that has generated considerable levels of invention but, while showing increasing volumes of activity over the past decades, it has not been recognized for generating the benefit in outcomes that might have been expected. One of the major reasons for this position has been the poor quality of evidence available to demonstrate the impact of laboratory investigations on health outcomes. Consequently an absence of evidence stifles the opportunity to develop the business case that demonstrates the link between test result and improved outcome. This has a major influence on the success of innovation in laboratory medicine. This review explores the process of innovation applied to laboratory medicine and offers an insight into how the impact of laboratory medicine on health outcomes can be improved. © 2013.

  11. Issues and challenges of implementing mobile e-Healthcare ...

    African Journals Online (AJOL)

    Mobile e-Healthcare implementation in South Africa has the potential to improve the delivery and access to healthcare services. However implementation of Mobile e-Healthcare continues to face various challenges such as inadequate policy, lack of management support, poor infrastructure and concerns around security of ...

  12. Challenges and opportunities of international clinical practica.

    Science.gov (United States)

    Mill, Judy E; Yonge, Olive J; Cameron, Brenda L

    2005-01-01

    International clinical practica are a strategy to integrate a global dimension in nursing curricula and achieve culturally sensitive nursing practice. In this paper, a review of the history and development of international practica for nursing students is presented, and research evaluating the effectiveness and impact of international experiences is analyzed. A description of experiences working with Canadian nursing students is used to highlight the challenges and opportunities inherent to international clinical practica. International student experiences involving clinical practica pose challenges that are additional to, and often more complex than, those faced in traditional international, course-based exchanges. The significant opportunities, however, continue to make international student practica a desirable and positive experience for Canadian nursing students.

  13. Vehicle Lightweighting: Challenges and Opportunities with Aluminum

    Science.gov (United States)

    Sachdev, Anil K.; Mishra, Raja K.; Mahato, Anirban; Alpas, Ahmet

    Rising energy costs, consumer preferences and regulations drive requirements for fuel economy, performance, comfort, safety and cost of future automobiles. These conflicting situations offer challenges for vehicle lightweighting, for which aluminum applications are key. This paper describes product design needs and materials and process development opportunities driven by theoretical, experimental and modeling tools in the area of sheet and castings. Computational tools and novel experimental techniques used in their development are described. The paper concludes with challenges that lie ahead for pervasive use of aluminum and the necessary fundamental R&D that is still needed.

  14. Interdisciplinarity and nursing research: opportunities and challenges

    OpenAIRE

    Carnevale,Franco A.

    2014-01-01

    Interdisciplinary collaboration is widely recognized and considered essential for optimizing the development of knowledge and practice. However, interdisciplinarity is commonly accepted as an unquestioned good; rarely examined as both a source of benefit as well as difficulty for nursing and other disciplines. The aim of this article is to critically examine the opportunities and challenges that interdisciplinarity can provide for research in nursing and other disciplines. Based on a North Am...

  15. Gender and social funds : challenges and opportunities

    OpenAIRE

    Kuehnast, Kathleen

    2003-01-01

    This report examines the various challenges and opportunities of mainstreaming gender issues in social fund projects and offers five good practice examples of gender integration in social fund projects in Ethiopia, Honduras, Malawi, Moldova, and Romania. Each case study takes gender into consideration during the preparation and implementation stages and discusses good design practices and project results. In addition, the report offers a set of working guidelines on integrating gender in soci...

  16. Computer Aided Modelling – Opportunities and Challenges

    DEFF Research Database (Denmark)

    2011-01-01

    This chapter considers the opportunities that are present in developing, extending and applying aspects of computer-aided modelling principles and practice. What are the best tasks to be done by modellers and what needs the application of CAPE tools? How do we efficiently develop model-based solu......This chapter considers the opportunities that are present in developing, extending and applying aspects of computer-aided modelling principles and practice. What are the best tasks to be done by modellers and what needs the application of CAPE tools? How do we efficiently develop model......-based solutions to significant problems? The important issues of workflow and data flow are discussed together with fit-for-purpose model development. As well, the lack of tools around multiscale modelling provides opportunities for the development of efficient tools to address such challenges. The ability...... to easily generate new models from underlying phenomena continues to be a challenge, especially in the face of time and cost constraints.Integrated frameworks that allow flexibility of model development and access to a range of embedded tools are central to future model developments. The challenges...

  17. Medical education in Albania: Challenges and opportunities.

    Science.gov (United States)

    Turkeshi, Eralda

    2011-01-01

    Albania is a small south-eastern European country still recovering from almost half a century of a fierce communist regime. While major reform and support have focused on healthcare and higher education (HE) in the past decade, there have not been major attempts to improve medical education. The time is now ready for medical education improvements created by increasing internal and external pressures as Albania aims to align its HE with the European Union standards and adapts the Bologna system. This article presents a summary of the current status of undergraduate, postgraduate and continuous medical education in Albania and suggests opportunities for development and partnerships that would help the country's medical education reform.

  18. Challenges and Opportunities of Airborne Metagenomics

    KAUST Repository

    Behzad, H.

    2015-05-06

    Recent metagenomic studies of environments, such as marine and soil, have significantly enhanced our understanding of the diverse microbial communities living in these habitats and their essential roles in sustaining vast ecosystems. The increase in the number of publications related to soil and marine metagenomics is in sharp contrast to those of air, yet airborne microbes are thought to have significant impacts on many aspects of our lives from their potential roles in atmospheric events such as cloud formation, precipitation, and atmospheric chemistry to their major impact on human health. In this review, we will discuss the current progress in airborne metagenomics, with a special focus on exploring the challenges and opportunities of undertaking such studies. The main challenges of conducting metagenomic studies of airborne microbes are as follows: 1) Low density of microorganisms in the air, 2) efficient retrieval of microorganisms from the air, 3) variability in airborne microbial community composition, 4) the lack of standardized protocols and methodologies, and 5) DNA sequencing and bioinformatics-related challenges. Overcoming these challenges could provide the groundwork for comprehensive analysis of airborne microbes and their potential impact on the atmosphere, global climate, and our health. Metagenomic studies offer a unique opportunity to examine viral and bacterial diversity in the air and monitor their spread locally or across the globe, including threats from pathogenic microorganisms. Airborne metagenomic studies could also lead to discoveries of novel genes and metabolic pathways relevant to meteorological and industrial applications, environmental bioremediation, and biogeochemical cycles.

  19. Big data business models: Challenges and opportunities

    Directory of Open Access Journals (Sweden)

    Ralph Schroeder

    2016-12-01

    Full Text Available This paper, based on 28 interviews from a range of business leaders and practitioners, examines the current state of big data use in business, as well as the main opportunities and challenges presented by big data. It begins with an account of the current landscape and what is meant by big data. Next, it draws distinctions between the ways organisations use data and provides a taxonomy of big data business models. We observe a variety of different business models, depending not only on sector, but also on whether the main advantages derive from analytics capabilities or from having ready access to valuable data sources. Some major challenges emerge from this account, including data quality and protectiveness about sharing data. The conclusion discusses these challenges, and points to the tensions and differing perceptions about how data should be governed as between business practitioners, the promoters of open data, and the wider public.

  20. Healthcare information systems: the cognitive challenge.

    Science.gov (United States)

    Lintern, Gavan; Motavalli, Al

    2018-01-11

    Healthcare work is, to a considerable extent, cognitive. Subsequently, the analysis and the design of supporting technology must be sensitive to the cognitive and adaptive demands of the work and to the cognitive strategies employed by healthcare practitioners. Despite the vital role that cognition plays in healthcare work, current technocentric design approaches for healthcare technology do not account for it, failing to observe it during analysis and failing to develop support for it during design. By review and analysis of case studies, we show that healthcare systems developed without input from cognitive analysis and cognitive design fail to take account of important healthcare work processes and workflows. In contrast, systems developed with a cognitively-focused design strategy demonstrate how it is possible to introduce technology that supports and enhances the work strategies of those engaged in patient care. Significant problems emerge when technological support systems are developed without any serious and comprehensive attempt to understand the cognitive capabilities and skills deployed by those involved in patient care. In contrast, significant benefits accrue from taking full account of those cognitive capabilities and skills. Subsequently, the design and development of supporting technology must be sensitive to the cognitive demands of the work and the cognitive strategies employed by healthcare practitioners.

  1. Cancer nanomedicine: progress, challenges and opportunities.

    Science.gov (United States)

    Shi, Jinjun; Kantoff, Philip W; Wooster, Richard; Farokhzad, Omid C

    2017-01-01

    The intrinsic limits of conventional cancer therapies prompted the development and application of various nanotechnologies for more effective and safer cancer treatment, herein referred to as cancer nanomedicine. Considerable technological success has been achieved in this field, but the main obstacles to nanomedicine becoming a new paradigm in cancer therapy stem from the complexities and heterogeneity of tumour biology, an incomplete understanding of nano-bio interactions and the challenges regarding chemistry, manufacturing and controls required for clinical translation and commercialization. This Review highlights the progress, challenges and opportunities in cancer nanomedicine and discusses novel engineering approaches that capitalize on our growing understanding of tumour biology and nano-bio interactions to develop more effective nanotherapeutics for cancer patients.

  2. Data Sharing: Convert Challenges into Opportunities

    Directory of Open Access Journals (Sweden)

    Ana Sofia Figueiredo

    2017-12-01

    Full Text Available Initiatives for sharing research data are opportunities to increase the pace of knowledge discovery and scientific progress. The reuse of research data has the potential to avoid the duplication of data sets and to bring new views from multiple analysis of the same data set. For example, the study of genomic variations associated with cancer profits from the universal collection of such data and helps in selecting the most appropriate therapy for a specific patient. However, data sharing poses challenges to the scientific community. These challenges are of ethical, cultural, legal, financial, or technical nature. This article reviews the impact that data sharing has in science and society and presents guidelines to improve the efficient sharing of research data.

  3. Challenges and opportunities of airborne metagenomics.

    Science.gov (United States)

    Behzad, Hayedeh; Gojobori, Takashi; Mineta, Katsuhiko

    2015-05-06

    Recent metagenomic studies of environments, such as marine and soil, have significantly enhanced our understanding of the diverse microbial communities living in these habitats and their essential roles in sustaining vast ecosystems. The increase in the number of publications related to soil and marine metagenomics is in sharp contrast to those of air, yet airborne microbes are thought to have significant impacts on many aspects of our lives from their potential roles in atmospheric events such as cloud formation, precipitation, and atmospheric chemistry to their major impact on human health. In this review, we will discuss the current progress in airborne metagenomics, with a special focus on exploring the challenges and opportunities of undertaking such studies. The main challenges of conducting metagenomic studies of airborne microbes are as follows: 1) Low density of microorganisms in the air, 2) efficient retrieval of microorganisms from the air, 3) variability in airborne microbial community composition, 4) the lack of standardized protocols and methodologies, and 5) DNA sequencing and bioinformatics-related challenges. Overcoming these challenges could provide the groundwork for comprehensive analysis of airborne microbes and their potential impact on the atmosphere, global climate, and our health. Metagenomic studies offer a unique opportunity to examine viral and bacterial diversity in the air and monitor their spread locally or across the globe, including threats from pathogenic microorganisms. Airborne metagenomic studies could also lead to discoveries of novel genes and metabolic pathways relevant to meteorological and industrial applications, environmental bioremediation, and biogeochemical cycles. © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  4. Healthcare-associated infections: challenges to public health in Brazil.

    Science.gov (United States)

    Padoveze, Maria Clara; Fortaleza, Carlos Magno Castelo Branco

    2014-12-01

    This study presents a critical evaluation of the scientific literature related to this subject, aiming to assess the policies and administrative issues regarding the prevention and magnitude of healthcare-associated infections and discuss the challenges for their prevention in Brazil. The topics discussed included historical and administrative issues, challenges imposed by the characteristics of the healthcare system and the territorial dimension, laboratorial support limitations, costs, institutional culture, professional qualification, and patient engagement. It is urgent to hold a nationwide discussion among government representatives, institutions, and healthcare workers and users to overcome these challenges.

  5. Additive manufacturing in production: challenges and opportunities

    Science.gov (United States)

    Ahuja, Bhrigu; Karg, Michael; Schmidt, Michael

    2015-03-01

    Additive manufacturing, characterized by its inherent layer by layer fabrication methodology has been coined by many as the latest revolution in the manufacturing industry. Due to its diversification of Materials, processes, system technology and applications, Additive Manufacturing has been synonymized with terminology such as Rapid prototyping, 3D printing, free-form fabrication, Additive Layer Manufacturing, etc. A huge media and public interest in the technology has led to an innovative attempt of exploring the technology for applications beyond the scope of the traditional engineering industry. Nevertheless, it is believed that a critical factor for the long-term success of Additive Manufacturing would be its ability to fulfill the requirements defined by the traditional manufacturing industry. A parallel development in market trends and product requirements has also lead to a wider scope of opportunities for Additive Manufacturing. The presented paper discusses some of the key challenges which are critical to ensure that Additive Manufacturing is truly accepted as a mainstream production technology in the industry. These challenges would highlight on various aspects of production such as product requirements, process management, data management, intellectual property, work flow management, quality assurance, resource planning, etc. In Addition, changing market trends such as product life cycle, mass customization, sustainability, environmental impact and localized production will form the foundation for the follow up discussion on the current limitations and the corresponding research opportunities. A discussion on ongoing research to address these challenges would include topics like process monitoring, design complexity, process standardization, multi-material and hybrid fabrication, new material development, etc.

  6. Interdisciplinarity and nursing research: opportunities and challenges

    Directory of Open Access Journals (Sweden)

    Franco A. Carnevale

    2014-12-01

    Full Text Available Interdisciplinary collaboration is widely recognized and considered essential for optimizing the development of knowledge and practice. However, interdisciplinarity is commonly accepted as an unquestioned good; rarely examined as both a source of benefit as well as difficulty for nursing and other disciplines. The aim of this article is to critically examine the opportunities and challenges that interdisciplinarity can provide for research in nursing and other disciplines. Based on a North American perspective, I describe the emergence of uni-disciplinary nursing research and the knowledge exchanges that occurred between nursing and other disciplines. I discuss the rise of interdisciplinary research, outline several examples of nursing participation in interdisciplinarity, and highlight the prominent benefits and difficulties associated with interdisciplinary research. I argue that authentic collaboration is required to conduct meaningful interdisciplinary research and describe how this can be promoted.

  7. Interdisciplinarity and nursing research: opportunities and challenges.

    Science.gov (United States)

    Carnevale, Franco A

    2014-01-01

    Interdisciplinary collaboration is widely recognized and considered essential for optimizing the development of knowledge and practice. However, interdisciplinarity is commonly accepted as an unquestioned good; rarely examined as both a source of benefit as well as difficulty for nursing and other disciplines. The aim of this article is to critically examine the opportunities and challenges that interdisciplinarity can provide for research in nursing and other disciplines. Based on a North American perspective, I describe the emergence of uni-disciplinary nursing research and the knowledge exchanges that occurred between nursing and other disciplines. I discuss the rise of interdisciplinary research, outline several examples of nursing participation in interdisciplinarity, and highlight the prominent benefits and difficulties associated with interdisciplinary research. I argue that authentic collaboration is required to conduct meaningful interdisciplinary research and describe how this can be promoted.

  8. New challenges and opportunities for industrial biotechnology

    Directory of Open Access Journals (Sweden)

    Chen Guo-Qiang

    2012-08-01

    Full Text Available Abstract Industrial biotechnology has not developed as fast as expected due to some challenges including the emergences of alternative energy sources, especially shale gas, natural gas hydrate (or gas hydrate and sand oil et al. The weaknesses of microbial or enzymatic processes compared with the chemical processing also make industrial biotech products less competitive with the chemical ones. However, many opportunities are still there if industrial biotech processes can be as similar as the chemical ones. Taking advantages of the molecular biology and synthetic biology methods as well as changing process patterns, we can develop bioprocesses as competitive as chemical ones, these including the minimized cells, open and continuous fermentation processes et al.

  9. New challenges and opportunities for industrial biotechnology

    Science.gov (United States)

    2012-01-01

    Industrial biotechnology has not developed as fast as expected due to some challenges including the emergences of alternative energy sources, especially shale gas, natural gas hydrate (or gas hydrate) and sand oil et al. The weaknesses of microbial or enzymatic processes compared with the chemical processing also make industrial biotech products less competitive with the chemical ones. However, many opportunities are still there if industrial biotech processes can be as similar as the chemical ones. Taking advantages of the molecular biology and synthetic biology methods as well as changing process patterns, we can develop bioprocesses as competitive as chemical ones, these including the minimized cells, open and continuous fermentation processes et al. PMID:22905695

  10. Cyberlearning for Climate Literacy: Challenges and Opportunities

    Science.gov (United States)

    McCaffrey, M. S.; Buhr, S. M.; Gold, A. U.; Ledley, T. S.; Mooney, M. E.; Niepold, F.

    2010-12-01

    Cyberlearning tools provide cost and carbon-efficient avenues for fostering a climate literate society through online engagement with learners. With climate change education becoming a Presidential Priority in 2009, funding for grants from NSF, NASA and NOAA is leading to a new generation of cyberlearning resources that supplement existing online resources. This paper provides an overview of challenges and opportunities relating to the online delivery of high quality, often complex climate science by examining several existing and emerging efforts, including the Climate Literacy and Energy Awareness Network (CLEAN,) a National Science Digital Library Pathway, the development by CIRES Education and Outreach of the Inspiring Climate Education Excellence (ICEE) online course, TERC’s Earth Exploration Toolbook (EET,) DataTools, and EarthLab modules, the NOAA Climate Stewards Education Program (CSEP) that utilizes the NSTA E-Learning Center, online efforts by members of the Federation of Earth Science Information Partners (ESIP), UCAR’s Climate Discovery program, and the Climate Adaptation, Mitigation e-Learning (CAMeL) project. In addition, we will summarize outcomes of the Cyberlearning for Climate Literacy workshop held in Washington DC in the Fall of 2009 and examine opportunities for teachers to develop and share their own lesson plans based on climate-related web resources that currently lack built-in learning activities, assessments or teaching tips.

  11. Technology in Parkinson disease: Challenges and Opportunities

    Science.gov (United States)

    Espay, Alberto J.; Bonato, Paolo; Nahab, Fatta; Maetzler, Walter; Dean, John M.; Klucken, Jochen; Eskofier, Bjoern M.; Merola, Aristide; Horak, Fay; Lang, Anthony E.; Reilmann, Ralf; Giuffrida, Joe; Nieuwboer, Alice; Horne, Malcolm; Little, Max A.; Litvan, Irene; Simuni, Tanya; Dorsey, E. Ray; Burack, Michelle A.; Kubota, Ken; Kamondi, Anita; Godinho, Catarina; Daneault, Jean-Francois; Mitsi, Georgia; Krinke, Lothar; Hausdorff, Jeffery M.; Bloem, Bastiaan R.; Papapetropoulos, Spyros

    2016-01-01

    The miniaturization, sophistication, proliferation, and accessibility of technologies are enabling the capturing of more and previously inaccessible phenomena in Parkinson disease (PD). However, more information has not translated into greater understanding of disease complexity to satisfy diagnostic and therapeutic needs. Challenges include non-compatible technology platforms, the need for wide-scale and long-term deployment of sensor technology (in particular among vulnerable elderly patients), and the gap between the “big data” acquired with sensitive measurement technologies and their limited clinical application. Major opportunities could be realized if new technologies are developed as part of open-source and/or open-hardware platforms enabling multi-channel data capture, sensitive to the broad range of motor and non-motor problems that characterize PD, and adaptable into self-adjusting, individualized treatment delivery systems. The International Parkinson and Movement Disorders Society Task Force on Technology is entrusted to convene engineers, clinicians, researchers, and patients to promote the development of integrated measurement and closed-loop therapeutic systems with high patient adherence that also serve to: 1) encourage the adoption of clinico-pathophysiologic phenotyping and early detection of critical disease milestones; 2) enhance tailoring of symptomatic therapy; 3) improve subgroup targeting of patients for future testing of disease modifying treatments; and 4) identify objective biomarkers to improve longitudinal tracking of impairments in clinical care and research. This article summarizes the work carried out by the Task Force toward identifying challenges and opportunities in the development of technologies with potential for improving the clinical management and quality of life of individuals with PD. PMID:27125836

  12. Technology in Parkinson's disease: Challenges and opportunities.

    Science.gov (United States)

    Espay, Alberto J; Bonato, Paolo; Nahab, Fatta B; Maetzler, Walter; Dean, John M; Klucken, Jochen; Eskofier, Bjoern M; Merola, Aristide; Horak, Fay; Lang, Anthony E; Reilmann, Ralf; Giuffrida, Joe; Nieuwboer, Alice; Horne, Malcolm; Little, Max A; Litvan, Irene; Simuni, Tanya; Dorsey, E Ray; Burack, Michelle A; Kubota, Ken; Kamondi, Anita; Godinho, Catarina; Daneault, Jean-Francois; Mitsi, Georgia; Krinke, Lothar; Hausdorff, Jeffery M; Bloem, Bastiaan R; Papapetropoulos, Spyros

    2016-09-01

    The miniaturization, sophistication, proliferation, and accessibility of technologies are enabling the capture of more and previously inaccessible phenomena in Parkinson's disease (PD). However, more information has not translated into a greater understanding of disease complexity to satisfy diagnostic and therapeutic needs. Challenges include noncompatible technology platforms, the need for wide-scale and long-term deployment of sensor technology (among vulnerable elderly patients in particular), and the gap between the "big data" acquired with sensitive measurement technologies and their limited clinical application. Major opportunities could be realized if new technologies are developed as part of open-source and/or open-hardware platforms that enable multichannel data capture sensitive to the broad range of motor and nonmotor problems that characterize PD and are adaptable into self-adjusting, individualized treatment delivery systems. The International Parkinson and Movement Disorders Society Task Force on Technology is entrusted to convene engineers, clinicians, researchers, and patients to promote the development of integrated measurement and closed-loop therapeutic systems with high patient adherence that also serve to (1) encourage the adoption of clinico-pathophysiologic phenotyping and early detection of critical disease milestones, (2) enhance the tailoring of symptomatic therapy, (3) improve subgroup targeting of patients for future testing of disease-modifying treatments, and (4) identify objective biomarkers to improve the longitudinal tracking of impairments in clinical care and research. This article summarizes the work carried out by the task force toward identifying challenges and opportunities in the development of technologies with potential for improving the clinical management and the quality of life of individuals with PD. © 2016 International Parkinson and Movement Disorder Society. © 2016 International Parkinson and Movement Disorder

  13. THE OPPORTUNITIES AND CHALLENGES OF MICROINSURANCE

    Directory of Open Access Journals (Sweden)

    Bente Corneliu

    2011-07-01

    Full Text Available Microinsurance is a term increasingly used to refer to insurance characterized by low premium and low caps or low coverage limits, sold as part of a typical risk-pooling and marketing arrangements, and designed to service low-income people and businesses not served by typical social or commercial insurance schemes. As a relatively new field, few studies evaluating the impact of microinsurance projects exist. Of these, even fewer have a rigorous methodology leading to reliable results. Our research aimed to: - examine the viability of microinsurance as a mechanism of risk transfer and tool for risk management in developing countries; - provide a state of the art analysis of microinsurance for a better understanding of currently operational microinsurance schemes; - reflect on the opportunities and challenges of microinsurance in developing countries, highlighting both the potential benefits and limitations of microinsurance as an instrument for transferring risk; - consider the interests and perspectives of different stakeholders and the incentives and disincentives for participating and investing in a micro-insurance scheme; - enhance dialogue and collaboration on this topic between and within the commercial insurance sector and the disaster risk reduction communities; - assess the opportunity of introducing microinsurance in Romania. Reflecting on the opportunities and challenges of introducing microinsurance in Romania, there is absolutely necessary to understand both the supply side (current insurance market and the demand side (risks faced by low-income persons and the coping strategies used to manage these risks. The majority of the primary research was conducted on-site in Romania, in Oradea and its environs, during the month of December 2010. Qualitative research techniques were utilized, including focus group discussions (FGD and guided individual interviews with members of both the public and private sector, as well as with

  14. Hybrid governance of aquaculture: Opportunities and challenges.

    Science.gov (United States)

    Vince, Joanna; Haward, Marcus

    2017-10-01

    The development of third party assessment and certification of fisheries and aquaculture has provided new forms of governance in sectors that were traditionally dominated by state based regulation. Emerging market based approaches are driven by shareholder expectations as well as commitment to corporate social responsibility, whereas community engagement is increasingly centered on the questions of social license to operate. Third party assessment and certification links state, market and community into an interesting and challenging hybrid form of governance. While civil society organizations have long been active in pursuing sustainable and safe seafood production, the development of formal non-state based certification provides both opportunities and challenges, and opens up interesting debates over hybrid forms of governance. This paper explores these developments in coastal marine resources management, focusing on aquaculture and the development and operation of the Aquaculture Stewardship Council. It examines the case of salmonid aquaculture in Tasmania, Australia, now Australia's most valuable seafood industry, which remains the focus of considerable community debate over its siting, operation and environmental impact. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. Hydrology Domain Cyberinfrastructures: Successes, Challenges, and Opportunities

    Science.gov (United States)

    Horsburgh, J. S.

    2015-12-01

    Anticipated changes to climate, human population, land use, and urban form will alter the hydrology and availability of water within the water systems on which the world's population relies. Understanding the effects of these changes will be paramount in sustainably managing water resources, as well as maintaining associated capacity to provide ecosystem services (e.g., regulating flooding, maintaining instream flow during dry periods, cycling nutrients, and maintaining water quality). It will require better information characterizing both natural and human mediated hydrologic systems and enhanced ability to generate, manage, store, analyze, and share growing volumes of observational data. Over the past several years, a number of hydrology domain cyberinfrastructures have emerged or are currently under development that are focused on providing integrated access to and analysis of data for cross-domain synthesis studies. These include the Consortium of Universities for the Advancement of Hydrologic Science, Inc. (CUAHSI) Hydrologic Information System (HIS), the Critical Zone Observatory Information System (CZOData), HyroShare, the BiG CZ software system, and others. These systems have focused on sharing, integrating, and analyzing hydrologic observations data. This presentation will describe commonalities and differences in the cyberinfrastructure approaches used by these projects and will highlight successes and lessons learned in addressing the challenges of big and complex data. It will also identify new challenges and opportunities for next generation cyberinfrastructure and a next generation of cyber-savvy scientists and engineers as developers and users.

  16. Brain metastasis: Unique challenges and open opportunities.

    Science.gov (United States)

    Lowery, Frank J; Yu, Dihua

    2017-01-01

    The metastasis of cancer to the central nervous system (CNS) remains a devastating clinical reality, carrying an estimated survival time of less than one year in spite of recent therapeutic breakthroughs for other disease contexts. Advances in brain metastasis research are hindered by a number of factors, including its complicated nature and the difficulty of modeling metastatic cancer growth in the unique brain microenvironment. In this review, we will discuss the clinical challenge, and compare the merits and limitations of the available models for brain metastasis research. Additionally, we will specifically address current knowledge on how brain metastases take advantage of the unique brain environment to benefit their own growth. Finally, we will explore the distinctive metabolic and chemical characteristics of the brain and how these paradoxically represent barriers to establishment of brain metastasis, but also provide ample supplies for metastatic cells' growth in the brain. We envision that multi-disciplinary innovative approaches will open opportunities for the field to make breakthroughs in tackling unique challenges of brain metastasis. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Crowdsourcing in biomedicine: challenges and opportunities.

    Science.gov (United States)

    Khare, Ritu; Good, Benjamin M; Leaman, Robert; Su, Andrew I; Lu, Zhiyong

    2016-01-01

    The use of crowdsourcing to solve important but complex problems in biomedical and clinical sciences is growing and encompasses a wide variety of approaches. The crowd is diverse and includes online marketplace workers, health information seekers, science enthusiasts and domain experts. In this article, we review and highlight recent studies that use crowdsourcing to advance biomedicine. We classify these studies into two broad categories: (i) mining big data generated from a crowd (e.g. search logs) and (ii) active crowdsourcing via specific technical platforms, e.g. labor markets, wikis, scientific games and community challenges. Through describing each study in detail, we demonstrate the applicability of different methods in a variety of domains in biomedical research, including genomics, biocuration and clinical research. Furthermore, we discuss and highlight the strengths and limitations of different crowdsourcing platforms. Finally, we identify important emerging trends, opportunities and remaining challenges for future crowdsourcing research in biomedicine. Published by Oxford University Press 2015. This work is written by US Government employees and is in the public domain in the US.

  18. Opportunities and challenges in biological lignin valorization.

    Science.gov (United States)

    Beckham, Gregg T; Johnson, Christopher W; Karp, Eric M; Salvachúa, Davinia; Vardon, Derek R

    2016-12-01

    Lignin is a primary component of lignocellulosic biomass that is an underutilized feedstock in the growing biofuels industry. Despite the fact that lignin depolymerization has long been studied, the intrinsic heterogeneity of lignin typically leads to heterogeneous streams of aromatic compounds, which in turn present significant technical challenges when attempting to produce lignin-derived chemicals where purity is often a concern. In Nature, microorganisms often encounter this same problem during biomass turnover wherein powerful oxidative enzymes produce heterogeneous slates of aromatics compounds. Some microbes have evolved metabolic pathways to convert these aromatic species via 'upper pathways' into central intermediates, which can then be funneled through 'lower pathways' into central carbon metabolism in a process we dubbed 'biological funneling'. This funneling approach offers a direct, biological solution to overcome heterogeneity problems in lignin valorization for the modern biorefinery. Coupled to targeted separations and downstream chemical catalysis, this concept offers the ability to produce a wide range of molecules from lignin. This perspective describes research opportunities and challenges ahead for this new field of research, which holds significant promise towards a biorefinery concept wherein polysaccharides and lignin are treated as equally valuable feedstocks. In particular, we discuss tailoring the lignin substrate for microbial utilization, host selection for biological funneling, ligninolytic enzyme-microbe synergy, metabolic engineering, expanding substrate specificity for biological funneling, and process integration, each of which presents key challenges. Ultimately, for biological solutions to lignin valorization to be viable, multiple questions in each of these areas will need to be addressed, making biological lignin valorization a multidisciplinary, co-design problem. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Opportunities and challenges in biological lignin valorization

    Energy Technology Data Exchange (ETDEWEB)

    Beckham, Gregg T.; Johnson, Christopher W.; Karp, Eric M.; Salvachúa, Davinia; Vardon, Derek R.

    2016-12-01

    Lignin is a primary component of lignocellulosic biomass that is an underutilized feedstock in the growing biofuels industry. Despite the fact that lignin depolymerization has long been studied, the intrinsic heterogeneity of lignin typically leads to heterogeneous streams of aromatic compounds, which in turn present significant technical challenges when attempting to produce lignin-derived chemicals where purity is often a concern. In Nature, microorganisms often encounter this same problem during biomass turnover wherein powerful oxidative enzymes produce heterogeneous slates of aromatics compounds. Some microbes have evolved metabolic pathways to convert these aromatic species via ‘upper pathways’ into central intermediates, which can then be funneled through ‘lower pathways’ into central carbon metabolism in a process we dubbed ‘biological funneling’. This funneling approach offers a direct, biological solution to overcome heterogeneity problems in lignin valorization for the modern biorefinery. Coupled to targeted separations and downstream chemical catalysis, this concept offers the ability to produce a wide range of molecules from lignin. This perspective describes research opportunities and challenges ahead for this new field of research, which holds significant promise towards a biorefinery concept wherein polysaccharides and lignin are treated as equally valuable feedstocks. In particular, we discuss tailoring the lignin substrate for microbial utilization, host selection for biological funneling, ligninolytic enzyme–microbe synergy, metabolic engineering, expanding substrate specificity for biological funneling, and process integration, each of which presents key challenges. Ultimately, for biological solutions to lignin valorization to be viable, multiple questions in each of these areas will need to be addressed, making biological lignin valorization a multidisciplinary, co-design problem.

  20. Opportunities and Challenges for Online Instruction in School Psychology Programs

    Science.gov (United States)

    Moy, Gregory; Chaffin, Jamie; Fischer, Aaron; Robbins, Stacey

    2017-01-01

    How do faculty take stock of their opportunities and challenges regarding online instruction? Furthermore, how do programs synthesize the opportunities and challenges they face to make decisions about whether or how to adopt online instructional practices? The primary aim of this article is to take stock of the opportunities and challenges…

  1. The state of psychogeriatrics in Europe: challenges and opportunities in six European countries

    NARCIS (Netherlands)

    Fernandes, L.; Mateos, R.; Engedal, K.; von Gunten, A.; Stek, M.L.; Ramakrishnan, A.; Ihl, R.; Wang, H.; Mintzer, J.; Brodaty, H.

    2015-01-01

    With the increase in aging all over the world, and the elderly population nearly tripling from 524 million (8% of the world's population) in 2010 to 1.5 billion (16% of the world's population) in 2050, we will face new challenges and opportunities in providing healthcare. In 2050, it is estimated

  2. Modular manufacturing processes : Status, challenges, and opportunities

    NARCIS (Netherlands)

    Baldea, Michael; Edgar, Thomas F.; Stanley, Bill L.; Kiss, Anton A.

    2017-01-01

    Chemical companies are constantly seeking new, high-margin growth opportunities, the majority of which lie in high-grade, specialty chemicals, rather than in the bulk sector. To realize these opportunities, manufacturers are increasingly considering decentralized, flexible production facilities:

  3. mHealth For Aging China: Opportunities and Challenges.

    Science.gov (United States)

    Sun, Jing; Guo, Yutao; Wang, Xiaoning; Zeng, Qiang

    2016-01-01

    The aging population with chronic and age-related diseases has become a global issue and exerted heavy burdens on the healthcare system and society. Neurological diseases are the leading chronic diseases in the geriatric population, and stroke is the leading cause of death in China. However, the uneven distribution of caregivers and critical healthcare workforce shortages are major obstacles to improving disease outcome. With the advancement of wearable health devices, cloud computing, mobile technologies and Internet of Things, mobile health (mHealth) is rapidly developing and shows a promising future in the management of chronic diseases. Its advantages include its ability to improve the quality of care, reduce the costs of care, and improve treatment outcomes by transferring in-hospital treatment to patient-centered medical treatment at home. mHealth could also enhance the international cooperation of medical providers in different time zones and the sharing of high-quality medical service resources between developed and developing countries. In this review, we focus on trends in mHealth and its clinical applications for the prevention and treatment of diseases, especially aging-related neurological diseases, and on the opportunities and challenges of mHealth in China. Operating models of mHealth in disease management are proposed; these models may benefit those who work within the mHealth system in developing countries and developed countries.

  4. Big Data: Survey, Technologies, Opportunities, and Challenges

    Directory of Open Access Journals (Sweden)

    Nawsher Khan

    2014-01-01

    Full Text Available Big Data has gained much attention from the academia and the IT industry. In the digital and computing world, information is generated and collected at a rate that rapidly exceeds the boundary range. Currently, over 2 billion people worldwide are connected to the Internet, and over 5 billion individuals own mobile phones. By 2020, 50 billion devices are expected to be connected to the Internet. At this point, predicted data production will be 44 times greater than that in 2009. As information is transferred and shared at light speed on optic fiber and wireless networks, the volume of data and the speed of market growth increase. However, the fast growth rate of such large data generates numerous challenges, such as the rapid growth of data, transfer speed, diverse data, and security. Nonetheless, Big Data is still in its infancy stage, and the domain has not been reviewed in general. Hence, this study comprehensively surveys and classifies the various attributes of Big Data, including its nature, definitions, rapid growth rate, volume, management, analysis, and security. This study also proposes a data life cycle that uses the technologies and terminologies of Big Data. Future research directions in this field are determined based on opportunities and several open issues in Big Data domination. These research directions facilitate the exploration of the domain and the development of optimal techniques to address Big Data.

  5. Rheumatology in Africa-challenges and opportunities.

    Science.gov (United States)

    Mody, Girish M

    2017-03-07

    Africa faces many health challenges despite sustained growth and development over the past decade. Contributory factors are the lack of financial resources, an inadequate health professional workforce, a high burden of communicable diseases, and an increasing burden of non-communicable diseases. Rheumatology services are limited or non-existent in many parts of sub-Saharan Africa. Over the past decade, partnerships with international academic institutions have resulted in some progress in the training of rheumatologists and health professionals and development of rheumatology services in countries such as Kenya, Nigeria, and Zambia. Basic diagnostic tests, biological agents, and arthroplasty are either unavailable or not affordable by the majority of the population. Urbanization has resulted in a change in the epidemiology of rheumatic diseases with an increase in the prevalence of gout, rheumatoid arthritis, systemic lupus erythematosus, and scleroderma over the past four decades. Future growth of rheumatology services will depend on identifying committed individuals in underserved countries for training and supporting them to educate medical students, physicians, and health professionals in their home countries. There is a need to develop models of care using all categories of health workers and identify prevention strategies and cost-effective management programs for low resource settings. Africa affords an opportunity for collaborative research, including genetic and epigenetic studies, to improve our understanding of many of the rheumatic diseases.

  6. Big Data: Survey, Technologies, Opportunities, and Challenges

    Science.gov (United States)

    Khan, Nawsher; Yaqoob, Ibrar; Hashem, Ibrahim Abaker Targio; Inayat, Zakira; Mahmoud Ali, Waleed Kamaleldin; Alam, Muhammad; Shiraz, Muhammad; Gani, Abdullah

    2014-01-01

    Big Data has gained much attention from the academia and the IT industry. In the digital and computing world, information is generated and collected at a rate that rapidly exceeds the boundary range. Currently, over 2 billion people worldwide are connected to the Internet, and over 5 billion individuals own mobile phones. By 2020, 50 billion devices are expected to be connected to the Internet. At this point, predicted data production will be 44 times greater than that in 2009. As information is transferred and shared at light speed on optic fiber and wireless networks, the volume of data and the speed of market growth increase. However, the fast growth rate of such large data generates numerous challenges, such as the rapid growth of data, transfer speed, diverse data, and security. Nonetheless, Big Data is still in its infancy stage, and the domain has not been reviewed in general. Hence, this study comprehensively surveys and classifies the various attributes of Big Data, including its nature, definitions, rapid growth rate, volume, management, analysis, and security. This study also proposes a data life cycle that uses the technologies and terminologies of Big Data. Future research directions in this field are determined based on opportunities and several open issues in Big Data domination. These research directions facilitate the exploration of the domain and the development of optimal techniques to address Big Data. PMID:25136682

  7. Big data: survey, technologies, opportunities, and challenges.

    Science.gov (United States)

    Khan, Nawsher; Yaqoob, Ibrar; Hashem, Ibrahim Abaker Targio; Inayat, Zakira; Ali, Waleed Kamaleldin Mahmoud; Alam, Muhammad; Shiraz, Muhammad; Gani, Abdullah

    2014-01-01

    Big Data has gained much attention from the academia and the IT industry. In the digital and computing world, information is generated and collected at a rate that rapidly exceeds the boundary range. Currently, over 2 billion people worldwide are connected to the Internet, and over 5 billion individuals own mobile phones. By 2020, 50 billion devices are expected to be connected to the Internet. At this point, predicted data production will be 44 times greater than that in 2009. As information is transferred and shared at light speed on optic fiber and wireless networks, the volume of data and the speed of market growth increase. However, the fast growth rate of such large data generates numerous challenges, such as the rapid growth of data, transfer speed, diverse data, and security. Nonetheless, Big Data is still in its infancy stage, and the domain has not been reviewed in general. Hence, this study comprehensively surveys and classifies the various attributes of Big Data, including its nature, definitions, rapid growth rate, volume, management, analysis, and security. This study also proposes a data life cycle that uses the technologies and terminologies of Big Data. Future research directions in this field are determined based on opportunities and several open issues in Big Data domination. These research directions facilitate the exploration of the domain and the development of optimal techniques to address Big Data.

  8. Perovskite Solar Cells: Potentials, Challenges, and Opportunities

    Directory of Open Access Journals (Sweden)

    Muhammad Imran Ahmed

    2015-01-01

    Full Text Available Heralded as a major scientific breakthrough of 2013, organic/inorganic lead halide perovskite solar cells have ushered in a new era of renewed efforts at increasing the efficiency and lowering the cost of solar energy. As a potential game changer in the mix of technologies for alternate energy, it has emerged from a modest beginning in 2012 to efficiencies being claimed at 20.1% in a span of just two years. This remarkable progress, encouraging at one end, also points to the possibility that the potential may still be far from being fully realized. With greater insight into the photophysics involved and optimization of materials and methods, this technology stands to match or even exceed the efficiencies for single crystal silicon solar cells. With thin film solution processability, applicability to flexible substrates, and being free of liquid electrolyte, this technology combines the benefits of Dye Sensitized Solar Cells (DSSCs, Organic Photovoltaics (OPVs, and thin film solar cells. In this review we present a brief historic perspective to this development, take a cognizance of the current state of the art, and highlight challenges and the opportunities.

  9. Nursing profession in Iran: an overview of opportunities and challenges.

    Science.gov (United States)

    Farsi, Zahra; Dehghan-Nayeri, Nahid; Negarandeh, Reza; Broomand, Soheila

    2010-06-01

    Iran's health-care system has witnessed profound changes in the last decades. Despite its progress, the system has currently faced many challenges in one of the important subsystems, nursing. The present review article aimed to present an overview of the opportunities and challenges of the Iranian nursing system, based on recent literature. A broad search of the English and Persian-language literature was carried out, incorporating both electronic and manual components from 1999 to 2009. The results of the investigations among the searched literature are summarized. The major challenges are nursing shortages, job dissatisfaction, poor social position of nurses, the gap between theory and practice, lack of community-based nursing care, lack of an appropriate student recruiting system, and shortages in the nursing educational curriculums. The authors believe that media, political and public support play a pivotal role in improving the image of nursing in society, increasing motivation among Iranian nurses, and promoting the sociocultural climate and the welfare of nurses, which will result in higher levels of quality of care as well as greater patient satisfaction.

  10. Mobile healthcare applications: system design review, critical issues and challenges.

    Science.gov (United States)

    Baig, Mirza Mansoor; GholamHosseini, Hamid; Connolly, Martin J

    2015-03-01

    Mobile phones are becoming increasingly important in monitoring and delivery of healthcare interventions. They are often considered as pocket computers, due to their advanced computing features, enhanced preferences and diverse capabilities. Their sophisticated sensors and complex software applications make the mobile healthcare (m-health) based applications more feasible and innovative. In a number of scenarios user-friendliness, convenience and effectiveness of these systems have been acknowledged by both patients as well as healthcare providers. M-health technology employs advanced concepts and techniques from multidisciplinary fields of electrical engineering, computer science, biomedical engineering and medicine which benefit the innovations of these fields towards healthcare systems. This paper deals with two important aspects of current mobile phone based sensor applications in healthcare. Firstly, critical review of advanced applications such as; vital sign monitoring, blood glucose monitoring and in-built camera based smartphone sensor applications. Secondly, investigating challenges and critical issues related to the use of smartphones in healthcare including; reliability, efficiency, mobile phone platform variability, cost effectiveness, energy usage, user interface, quality of medical data, and security and privacy. It was found that the mobile based applications have been widely developed in recent years with fast growing deployment by healthcare professionals and patients. However, despite the advantages of smartphones in patient monitoring, education, and management there are some critical issues and challenges related to security and privacy of data, acceptability, reliability and cost that need to be addressed.

  11. CPV 101: Intro to CPV Technology, Opportunities and Challenges (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Kurtz, S.

    2009-10-26

    The presentation describes Concentrating Photovoltaic power (CPV), why it is important, the associated the opportunities and challenges, and more than 5-dozen companies that are pursuing the approach.

  12. COMPLEX NETWORKS IN CLIMATE SCIENCE: PROGRESS, OPPORTUNITIES AND CHALLENGES

    Data.gov (United States)

    National Aeronautics and Space Administration — COMPLEX NETWORKS IN CLIMATE SCIENCE: PROGRESS, OPPORTUNITIES AND CHALLENGES KARSTEN STEINHAEUSER, NITESH V. CHAWLA, AND AUROOP R. GANGULY Abstract. Networks have...

  13. Understanding Challenges and Opportunities of Preventive Blood Pressure Self-Monitoring at Home

    DEFF Research Database (Denmark)

    Grönvall, Erik; Verdezoto, Nervo

    2013-01-01

    methods to understand existing challenges and uncover opportunities of self-monitoring technologies to support preventive healthcare activities among older adults. Emerging challenges from our study were: rule complexity for self-measuring, reliability of measurements, interpretation, understanding...... to support people’s preventive self-monitoring needs compared with existing solutions. Furthermore, supporting the active and informed citizen can improve older adult’s care abilities, awareness and activation towards preventive care....

  14. Engineering: issues, challenges and opportunities for development

    CSIR Research Space (South Africa)

    Wall, K

    2010-10-01

    Full Text Available The critical roles of engineering in addressing the large-scale pressing challenges facing our societies worldwide are widely recognized. Such large-scale challenges include access to affordable health care; tackling the coupled issues of energy...

  15. An Overview of the Challenges and Opportunities for Globalization ...

    African Journals Online (AJOL)

    The paper is an overview of the existing challenges and opportunities of globalization of Nigerian libraries. It examine the challenges and opportunities for the establishment of viable information and communication. Technologies (ICTs) and recommends the way forward for interconnectivity of Nigerian libraries to facilitate ...

  16. Hazardous drugs: new challenges, new opportunities

    Directory of Open Access Journals (Sweden)

    Silvia Valero García

    2016-03-01

    Full Text Available Occupational exposure to hazardous drugs can cause harmful effects on health professionals and several protective measures must be taken. Nevertheless, classification of hazardous drugs is not the same in all the published repertoires and the terminology is still confusing: hazardous drugs, biohazardous drugs or risky drugs are terms improperly described and can define very different drugs with a very different hazard profiles. In Spain, there is not an updated official list of hazardous drugs, and healthcare professionals must consider and follow other published lists. In our opinion, it is mandatory to do a consensus among these professionals, administration and labor union organizations in order to clarify some conflictive questions not only in healthcare settings but in investigational and academic scenarios too. These multidisciplinary groups should be involved also in teaching new and non-experienced personnel and in the knowledge reinforcement for the experienced ones

  17. Healthcare professionals' accounts of challenges in managing motor neurone disease in primary healthcare: a qualitative study.

    Science.gov (United States)

    Lerum, Sverre Vigeland; Solbraekke, Kari Nyheim; Frich, Jan C

    2017-07-01

    Motor neurone disease (MND) is a progressive neurological disease causing muscle wasting, gradual paralysis and respiratory failure, with a life expectancy of 2-4 years. In order to better understand how MND is managed in the community, we conducted a qualitative study to explore the challenges healthcare professionals encounter when managing MND in primary healthcare. Based on data from 15 semi-structured interviews with primary healthcare professionals in Norway, we found that MND is viewed as a condition that requires exceptional effort and detailed planning. Healthcare professionals reported five main challenges in managing MND in primary healthcare: (i) building relationships with those giving and receiving care in the home; (ii) preventing caregiver burnout and breakdown; (iii) providing tailored care; (iv) ensuring good working conditions in patients' homes; and (v) recruiting and retaining qualified nursing assistants. Healthcare professionals reported needing working conditions that allow them to tailor their approach to the personal, emotional and existential nature of care preferences of those living with MND. However, people with MND and their families were sometimes perceived by healthcare professionals to prefer a strictly task-focused relationship with care providers. Such relationships limited the healthcare professionals' control over the MND trajectory and their capacity to prevent family caregiver burnout and breakdown. Adequate resources, along with training and support of nursing assistants, may increase the continuity of nursing assistants. Responsiveness to patient and family needs may enhance collaboration and promote tailored primary care and support for patients with MND and their families. © 2017 John Wiley & Sons Ltd.

  18. STATUS, CHALLENGES AND MARKETING OPPORTUNITIES FOR ...

    African Journals Online (AJOL)

    kitonyo

    A study was, therefore, conducted to determine the status, constraints and marketing opportunities for canning navy bean in Kenya. SURVEY METHODOLOGY. A survey was conducted along the navy bean product value chain as previously defined [5]. The survey took place during January-February 2010 growing period.

  19. Looking Forward: New Challenges and Opportunities

    Science.gov (United States)

    Bushnell, Elizabeth J.

    2012-01-01

    It is essential for higher education professionals to remain abreast of industry trends, emerging fields, and changing requirements that affect the job market and advanced education opportunities for new graduates. Equally important is a continual review of evolving strategies for success in the job search itself. Common practices in today's…

  20. The Remarried Family: Challenges and Opportunities.

    Science.gov (United States)

    Dolan, Elizabeth M.; Lown, Jean M.

    1985-01-01

    This article reviews remarriage trends and the social, financial, and developmental challenges facing remarried families. The article suggests ways home economists can apply their skills to help strengthen these families through research, education, and service. (CT)

  1. Challenges and opportunities in multichannel customer management

    NARCIS (Netherlands)

    Neslin, Scott A.; Grewal, Dhruv; Leghorn, Robert; Shankar, Venkatesh; Teerling, Marije L.; Thomas, Jacquelyn S.; Verhoef, Peter C.

    2006-01-01

    Multichannel customer management is the design, deployment, coordination, and evaluation of channels through which firms and customers interact, with the goal of enhancing customer value through effective customer acquisition, retention, and development. The authors identify five major challenges

  2. China - opportunities and challenges for world shipping

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    The report provides critical insight into the events and developments that will be shaping China`s trade and shipping role in the next decade, focusing on the issues which lie at the heart of the concerns (whether seen as opportunities or threats) of ship owners, operators, port interests and those who support the shipping industry either financially or through the provision of services. Chapter headings are: economic and industrial profile; principal dry bulk trades (including coal, coking coal, coal ports and infrastructure developments iron ore etc.); liquid trades (including crude oil, natural gas and LPG); container trades; refrigerated cargo (reefer trends); China`s maritime fleet; shipbuilding, ship repair and demolition; and outlook and opportunities for world shipping.

  3. Supranational Infrastructure Regulation: Institutional Opportunities and Challenges

    OpenAIRE

    Antonio Estache; Liam Wren-Lewis

    2012-01-01

    As regions around the world are considering increased integration of key energy, transport or other infrastructure networks, issues build in the design of the supranational national regulation needed in that context are increasingly well recognized. Solutions are however slow to emerge. This paper reviews the challenges and discusses the directions suggested by theory to address these challenges. It highlight the potentially counterproductive effects of common standard policy recommendations ...

  4. Neurofeedback: Challenges, Applications, and Opportunities for Education

    OpenAIRE

    Chan, Shuet Ying Sofina

    2015-01-01

    This thesis reviews the current state-of-the-art in neurofeedback research and then goes on to consider three fundamental problems for the psychology of education: first, to what extent can the mind cause changes in the brain at will; second, to what extent can studies in neurofeedback be considered to have validity; and third, given positive outcomes for the first two, to what extent can students become more adept at neurofeedback. Opportunities of neurofeedback for education are contingent ...

  5. Big Data and Analytics in Higher Education: Opportunities and Challenges

    Science.gov (United States)

    Daniel, Ben

    2015-01-01

    Institutions of higher education are operating in an increasingly complex and competitive environment. This paper identifies contemporary challenges facing institutions of higher education worldwide and explores the potential of Big Data in addressing these challenges. The paper then outlines a number of opportunities and challenges associated…

  6. Polypathology, an emerging phenomenon and a challenge for healthcare systems.

    Science.gov (United States)

    Román, P; Ruiz-Cantero, A

    2017-05-01

    Improvements in living conditions and scientific advances have led to an unprecedented demographic change. The curing of numerous acute diseases and the growing adoption of unhealthy lifestyles have caused a pandemic of cumulative chronic diseases that constitute the leading cause of death worldwide. Currently, the most common situation is the coexistence of multiple chronic diseases (or polypathology). This situation undermines socio-economic development and increases inequality. This results in an overriding need to change the way in which health and disease are addressed. Healthcare systems are not prepared to meet the needs of complex polypathological patients. In this article, we summarise the challenges facing healthcare systems and states, as well as the main recommendations from the organisations responsible for healthcare. Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.

  7. Challenges and opportunities of undergraduate research

    Science.gov (United States)

    Topasna, Daniela M.; Topasna, Gregory A.

    2009-03-01

    Undergraduate research at small schools is becoming the norm rather than the exception that it was years ago. Faculties are now faced with the challenges of incorporating students with varying degrees of academic preparedness and motivation in their research. This coupled with the students' own constraints within the academic schedule can make undergraduate research a challenge for both students and faculty. Like many small undergraduate schools, VMI's faculty and students are faced with these obstacles when engaging in undergraduate research. However, such difficulties can lead to creative solutions that lead to multiple benefits for students and faculty mentors. We present our unique perspective and experiences for this challenging yet rewarding experience as related to thin film research performed at VMI.

  8. Adolescent Healthcare Brokering: Prevalence, Experience, Impact, and Opportunities

    Science.gov (United States)

    Banas, Jennifer R.; Wallis, Lisa C.; Ball, James W.; Gershon, Sarah

    2016-01-01

    Background: Limited health literacy disproportionately affects those with limited English proficiency (LEP). Parents with LEP might rely on their adolescent children to interpret health information. We call this "adolescent healthcare brokering." This study uncovers the prevalence of brokering, kinds of tasks, emotional and academic…

  9. Independent midwifery practice: Opportunities and challenges | du ...

    African Journals Online (AJOL)

    A qualitative approach was used and midwives, who work in solo (independent) practice, were identified on the internet and via Facebook and invited to participate. Interviews and narrative reports were used for data gathering. Although passionate about their jobs, the most challenging aspect for the midwives, was inter- ...

  10. Professional development and leadership training opportunities for healthcare professionals.

    Science.gov (United States)

    Sonnino, Roberta E

    2013-11-01

    Formal leadership training is a relatively recent addition to the educational armamentarium of the health care executive. Leadership training opportunities for physicians, surgeons, and scientists have gradually appeared over the past 15 to 20 years, but information about them has been scant, with few comprehensive reviews made available to the community at large. This article describes the major opportunities available to obtain formal and informal leadership training for careers in medical school administration. Programs that are specifically targeted to women are described in detail. Information was obtained from the author's direct knowledge, direct communication with the leadership of each program, and the Web site of each sponsoring organization, when available. Many opportunities for leadership training are now available to surgeons, with several specifically designed for women. The author strongly encourages surgeons to avail themselves of these opportunities, as both anecdotal information and published data suggest that these programs are highly effective in enhancing leadership careers. Copyright © 2013 Elsevier Inc. All rights reserved.

  11. Opportunities and Challenges in Crowdsourced Wardriving

    DEFF Research Database (Denmark)

    Sapiezynski, Piotr; Gatej, Radu; Mislove, Alan

    2015-01-01

    Knowing the physical location of a mobile device is crucial for a number of context-aware applications. This information is usually obtained using the Global Positioning System (GPS), or by calculating the position based on proximity of WiFi access points with known location (where the position...... are collected by mobile devices automatically, and are maintained by large mobile OS providers. As a result, the research community has a poor understanding of the challenges in creating and using large-scale WiFi localization databases. We address this situation using the deployment of over 800 mobile devices...... to real users over a 1.5 year period. Each device periodically records WiFi scans and its GPS coordinates, reporting the collected data to us. We identify a number of challenges in using such data to build a WiFi localization database (e.g., mobility of access points), and introduce techniques to mitigate...

  12. Globalization And Women: Challenges And Opportunities

    OpenAIRE

    Naierossadat Daneshvar Hosseini

    2011-01-01

    There is growing evidence illustrating means in which a substantial number of women have been adversely affected by globalization, both absolutely as well as in relation to men. Women have also been more adversely affected during the increasing number of financial crisis generated by globalization while being disadvantaged by cuts in social protection. Women are more in danger in confronting the new global challenges. For example, they are disproportionately affected by different diseases, pa...

  13. Plant growth promoting rhizobia: challenges and opportunities

    OpenAIRE

    Gopalakrishnan, Subramaniam; Sathya, Arumugam; Vijayabharathi, Rajendran; Varshney, Rajeev Kumar; Gowda, C. L. Laxmipathi; Krishnamurthy, Lakshmanan

    2014-01-01

    Modern agriculture faces challenges, such as loss of soil fertility, fluctuating climatic factors and increasing pathogen and pest attacks. Sustainability and environmental safety of agricultural production relies on eco-friendly approaches like biofertilizers, biopesticides and crop residue return. The multiplicity of beneficial effects of microbial inoculants, particularly plant growth promoters (PGP), emphasizes the need for further strengthening the research and their use in modern agricu...

  14. Blockchain for Enterprise: Overview, Opportunities and Challenges

    OpenAIRE

    Ben Hamida, Elyes; Brousmiche, Kei Leo; Levard, Hugo; Thea, Eric

    2017-01-01

    International audience; The Blockchain technology has received increased interests in recent years, from both the scientific community and the industry. This technology represents a major paradigm shift in the way smart cities solutions will be built, operated, consumed and marketed in the near future. Even though Blockchains will have a tremendous potential impact on businesses and societies, there are many open challenges that need to be carefully tackled. This article focuses on enterprise...

  15. Processing Challenges and Opportunities of Camel Dairy Products

    OpenAIRE

    Berhe, Tesfemariam; Eyassu SEIFU; Ipsen, Richard; Kurtu, Mohamed Y; Hansen, Egon Bech

    2017-01-01

    A review on the challenges and opportunities of processing camel milk into dairy products is provided with an objective of exploring the challenges of processing and assessing the opportunities for developing functional products from camel milk. The gross composition of camel milk is similar to bovine milk. Nonetheless, the relative composition, distribution, and the molecular structure of the milk components are reported to be different. Consequently, manufacturing of camel dairy products su...

  16. Exploring Challenges and Opportunities for Eco-Feedback Technology

    DEFF Research Database (Denmark)

    Verdezoto, Nervo

    This position paper explores challenges and opportunities for eco-feedback technology. Drawing on two design cases, I discuss the importance of supporting active participation as well as the articulation of work in everyday practices to facilitate reduction of consumption.......This position paper explores challenges and opportunities for eco-feedback technology. Drawing on two design cases, I discuss the importance of supporting active participation as well as the articulation of work in everyday practices to facilitate reduction of consumption....

  17. Internet of Things challenges and opportunities

    CERN Document Server

    2014-01-01

    Advancement in sensor technology, smart instrumentation, wireless sensor networks, miniaturization, RFID and information processing is helping towards the realization of Internet of Things (IoT). IoTs are finding applications in various area applications including environmental monitoring, intelligent buildings, smart grids and so on. This book provides design challenges of IoT, theory, various protocols, implementation issues and a few case study. The book will be very useful for postgraduate students and researchers to know from basics to implementation of IoT.

  18. Challenges and opportunities in social neuroscience

    Science.gov (United States)

    Cacioppo, John T.; Decety, Jean

    2010-01-01

    Social species are so characterized because they form organizations that extend beyond the individual. The goal of social neuroscience is to investigate the biological mechanisms that underlie these social structures, processes, and behavior and the influences between social and neural structures and processes. Such an endeavor is challenging because it necessitates the integration of multiple levels. Mapping across systems and levels (from genome to social groups and cultures) requires interdisciplinary expertise, comparative studies, innovative methods, and integrative conceptual analysis. Examples of how social neuroscience is contributing to our understanding of the functions of the brain and nervous system are described, and societal implications of social neuroscience are considered. PMID:21251011

  19. Disaster nursing in Iran: challenges and opportunities.

    Science.gov (United States)

    Zarea, Kourosh; Beiranvand, Samira; Sheini-Jaberi, Parisa; Nikbakht-Nasrabadi, Alireza

    2014-11-01

    Disaster nursing was one of the first forms of nursing practice in Iran, and nurses have long served voluntarily in disasters. Despite their key role throughout a disaster management cycle, few studies have examined nurses' unique role in the management of disasters in this region of the world. An integrative narrative analysis of international research published in English and Persian studies between years 2000 and 2013 was conducted. Analysis of the 32 articles yielded two major: organisational and managerial challenges, and challenges linked to the educational system. The most significant factors linked to the role of nurses in disasters included the lack of identification of those who educated nurses to serve in critical conditions, defects in university's educational systems and lack of in-service training for nurses with regard to disasters. The integration of dedicate organisational units to educate human workforces, formalising a relationship between nursing staff and the disaster organisations, creative educational content, and effective economical systems to educate nurses may further enable disaster preparedness and response. Copyright © 2014 College of Emergency Nursing Australasia Ltd. Published by Elsevier Ltd. All rights reserved.

  20. Cloud Computing: Opportunities and Challenges for Businesses

    Directory of Open Access Journals (Sweden)

    İbrahim Halil Seyrek

    2011-12-01

    Full Text Available Cloud computing represents a new approach for supplying and using information technology services. Considering its benefits for firms and the potential of changes that it may lead to, it is envisioned that cloud computing can be the most important innovation in information technology since the development of the internet. In this study, firstly, the development of cloud computing and related technologies are explained and classified by giving current application examples. Then the benefits of this new computing model for businesses are elaborated especially in terms of cost, flexibility and service quality. In spite of its benefits, cloud computing also poses some risks for firms, of which security is one of the most important, and there are some challenges in its implementation. This study points out the risks that companies should be wary about and some legal challenges related to cloud computing. Lastly, approaches that companies may take against cloud computing and different strategies that they may adopt are discussed and some recommendations are made

  1. Vehicular Internet: Security & Privacy Challenges and Opportunities

    Directory of Open Access Journals (Sweden)

    Kamran Zaidi

    2015-07-01

    Full Text Available The vehicular internet will drive the future of vehicular technology and intelligent transportation systems (ITS. Whether it is road safety, infotainment, or driver-less cars, the vehicular internet will lay the foundation for the future of road travel. Governments and companies are pursuing driver-less vehicles as they are considered to be more reliable than humans and, therefore, safer. The vehicles today are not just a means of transportation but are also equipped with a wide range of sensors that provide valuable data. If vehicles are enabled to share data that they collect with other vehicles or authorities for decision-making and safer driving, they thereby form a vehicular network. However, there is a lot at stake in vehicular networks if they are compromised. With the stakes so high, it is imperative that the vehicular networks are secured and made resilient to any attack or attempt that may have serious consequences. The vehicular internet can also be the target of a cyber attack, which can be devastating. In this paper, the opportunities that the vehicular internet offers are presented and then various security and privacy aspects are discussed and some solutions are presented.

  2. Nanomanufacturing and sustainability: opportunities and challenges

    Energy Technology Data Exchange (ETDEWEB)

    Busnaina, Ahmed A., E-mail: BUSNAINA@COE.NEU.EDU [Northeastern University, NSF Nanoscale Science and Engineering Center for High-rate Nanomanufacturing (United States); Mead, Joey [University of Massachusetts Lowell (United States); Isaacs, Jacqueline; Somu, Sivasubramanian [Northeastern University, NSF Nanoscale Science and Engineering Center for High-rate Nanomanufacturing (United States)

    2013-10-15

    New nanomanufacturing technologies, although still in research labs, present a great opportunity to drastically reduce the cost of making nanostructures on a large scale and at high-rates. Such new bottom-up directed assembly-based approaches involve adding materials selectively thereby both reducing waste and the number of required processes. Directed assembly-based processes are conducted at room pressure and temperatures which significantly reduces the cost of nanomanufacturing equipment and tools, ensuring long-term sustainability by reducing energy, consumables, and waste costs. This paradigm shift in nanomanufacturing will unleash not only a wave of creativity in sustainable nanomanufacturing but lessons learnt along the way can be used in various other sectors. Along with the exquisite technological promise that nanotechnology holds, nano-enabled products are heralded as a means for energy and resource reduction, resulting in potential manufacturing cost reductions and further, for potential improvements to environmental remediation. Sustainable nanomanufacturing will, by dramatically lowering current nanomanufacturing barriers, spur innovation, and the creation of entirely new industries by leveling the playing and ultimately leading to the democratization of nanomanufacturing.

  3. Nanomanufacturing and sustainability: opportunities and challenges

    Science.gov (United States)

    Busnaina, Ahmed A.; Mead, Joey; Isaacs, Jacqueline; Somu, Sivasubramanian

    2013-10-01

    New nanomanufacturing technologies, although still in research labs, present a great opportunity to drastically reduce the cost of making nanostructures on a large scale and at high-rates. Such new bottom-up directed assembly-based approaches involve adding materials selectively thereby both reducing waste and the number of required processes. Directed assembly-based processes are conducted at room pressure and temperatures which significantly reduces the cost of nanomanufacturing equipment and tools, ensuring long-term sustainability by reducing energy, consumables, and waste costs. This paradigm shift in nanomanufacturing will unleash not only a wave of creativity in sustainable nanomanufacturing but lessons learnt along the way can be used in various other sectors. Along with the exquisite technological promise that nanotechnology holds, nano-enabled products are heralded as a means for energy and resource reduction, resulting in potential manufacturing cost reductions and further, for potential improvements to environmental remediation. Sustainable nanomanufacturing will, by dramatically lowering current nanomanufacturing barriers, spur innovation, and the creation of entirely new industries by leveling the playing and ultimately leading to the democratization of nanomanufacturing.

  4. Complex plasmas scientific challenges and technological opportunities

    CERN Document Server

    Lopez, Jose; Becker, Kurt; Thomsen, Hauke

    2014-01-01

    This book provides the reader with an introduction to the physics of complex plasmas, a discussion of the specific scientific and technical challenges they present, and an overview of their potential technological applications. Complex plasmas differ from conventional high-temperature plasmas in several ways: they may contain additional species, including nanometer- to micrometer-sized particles, negative ions, molecules and radicals, and they may exhibit strong correlations or quantum effects. This book introduces the classical and quantum mechanical approaches used to describe and simulate complex plasmas. It also covers some key experimental techniques used in the analysis of these plasmas, including calorimetric probe methods, IR absorption techniques and X-ray absorption spectroscopy. The final part of the book reviews the emerging applications of microcavity and microchannel plasmas, the synthesis and assembly of nanomaterials through plasma electrochemistry, the large-scale generation of ozone using mi...

  5. Challenges and Opportunities for Harmonizing Research Methodology

    DEFF Research Database (Denmark)

    van Hees, V. T.; Thaler-Kall, K.; Wolf, K. H.

    2016-01-01

    Objectives: Raw accelerometry is increasingly being used in physical activity research, but diversity in sensor design, attachment and signal processing challenges the comparability of research results. Therefore, efforts are needed to harmonize the methodology. In this article we reflect on how...... increased methodological harmonization may be achieved. Methods: The authors of this work convened for a two-day workshop (March 2014) themed on methodological harmonization of raw accelerometry. The discussions at the workshop were used as a basis for this review. Results: Key stakeholders were identified...... algorithms which are pitched as "ready for implementation" should be shared with the community to facilitate replication and ongoing evaluation by independent groups, and v) A dynamic interaction between method stakeholders should be encouraged to facilitate a well-informed harmonization process. Conclusions...

  6. Nanomaterials and Water Purification: Opportunities and Challenges

    Science.gov (United States)

    Savage, Nora; Diallo, Mamadou S.

    2005-10-01

    Advances in nanoscale science and engineering suggest that many of the current problems involving water quality could be resolved or greatly ameliorated using nanosorbents, nanocatalysts, bioactive nanoparticles, nanostructured catalytic membranes and nanoparticle enhanced filtration among other products and processes resulting from the development of nanotechnology. Innovations in the development of novel technologies to desalinate water are among the most exciting and promising. Additionally, nanotechnology-derived products that reduce the concentrations of toxic compounds to sub-ppb levels can assist in the attainment of water quality standards and health advisories. This article gives an overview of the use of nanomaterials in water purification. We highlight recent advances on the development of novel nanoscale materials and processes for treatment of surface water, groundwater and industrial wastewater contaminated by toxic metal ions, radionuclides, organic and inorganic solutes, bacteria and viruses. In addition, we discuss some challenges associated with the development of cost effective and environmentally acceptable functional nanomaterials for water purification.

  7. Ammonia for hydrogen storage: challenges and opportunities

    DEFF Research Database (Denmark)

    Klerke, Asbjørn; Christensen, Claus H.; Nørskov, Jens Kehlet

    2008-01-01

    and alcohols, it has the advantage that there is no CO2 emission at the end user. The drawbacks are mainly the toxicity of liquid ammonia and the problems related to trace amounts of ammonia in the hydrogen after decomposition. Storage of ammonia in metal ammine salts is discussed, and it is shown......The possibility of using ammonia as a hydrogen carrier is discussed. Compared to other hydrogen storage materials, ammonia has the advantages of a high hydrogen density, a well-developed technology for synthesis and distribution, and easy catalytic decomposition. Compared to hydrocarbons...... that this maintains the high volumetric hydrogen density while alleviating the problems of handling the ammonia. Some of the remaining challenges for research in ammonia as a hydrogen carrier are outlined....

  8. Cross Cultural Collaboration: Opportunities and Challenges

    Directory of Open Access Journals (Sweden)

    Christina Ho

    2009-08-01

    Full Text Available This paper introduces the next section of this special issue, which examines the politics of cross-cultural collaboration to resist racism and war. In an era defined by a ‘War on Terror’ which has transformed both foreign policy and domestic community relations, social movements need to find more effective ways of bringing activists together to respond to the Islamophobia and aggressive forms of nationalism that have emerged in countries like Australia. However, as the paper shows, collaboration across cultures is a fraught and potentially dangerous process. In outlining some of the challenges of cross-cultural collaboration, the paper aims to contribute to more informed and critical practices within social movements mobilising against the ‘War on Terror’, whether internationally or at home.

  9. Sustainable Tourism: Progress Challenges and Opportunities

    DEFF Research Database (Denmark)

    Budeanu, Adriana; Miller, Graham; Moscardo, Gianna

    2016-01-01

    are organised into four thematic areas of research: community stakeholders' perspectives and business approaches to sustainability in tourism, cultural responses, and methodological challenges related to sustainability. The articles shine a light on issues of importance within sustainable tourism, and in so......The term sustainable tourism emerged in the late 1980s and has become firmly established in both tourism policies and strategies and tourism research (Hall, 2011). After more than 25 years of attention it is timely to consider the state of research and practice in sustainable tourism. This special...... volume was established with exactly that goal in mind and this introduction seeks to set the context for this critical examination and reflection on sustainable tourism. Another objective of this introduction was to briefly describe the range of contributions selected for this SV. The articles...

  10. Nuclear Hybrid Energy Systems: Challenges and Opportunities

    Energy Technology Data Exchange (ETDEWEB)

    P. Sabharwall; S.B. Sitton; S.J. Yoon; C. Stoots

    2014-07-01

    With growing demand of energy and costs of the fossil fuels, coupled with the environmental concerns have resulted in an increased interest in alternative energy sources. Nuclear hybrid energy systems (NHES) are being considered which incorporates renewable energy sources such as solar and wind energy combined with nuclear reactor and energy storage to meet the peak hours demand imposed on the grid, along with providing process heat for other potential industrial applications. This concept could potentially satisfy various energy demands and improve reliability, robustness and resilience for the entire system as a whole, along with economic and net efficiency gains. This paper provides a brief understanding of potential NHES system and architecture along with the challenges

  11. Marine-Derived Pharmaceuticals - Challenges and Opportunities.

    Science.gov (United States)

    Lindequist, Ulrike

    2016-11-01

    Marine biosphere is the largest one of the earth and harbors an enormous number of different organisms. Living conditions differ fundamentally from those in terrestrial environment. The production of specific secondary metabolites is an important adaption mechanism of marine organisms to survive in the sea. These metabolites possess biological activities which make them interesting as possible drugs for human. The review presents sources, chemistry, production and pharmacology of FDA approved marine derived pharmaceuticals arranged according to their therapeutic indication. Four of the presently seven approved drugs are used for the treatment of cancer. Each another one is applicated for treatment of viral diseases, chronic pain and to lower triglyceride level in blood. Some other products are of interest in diagnostic and as experimental tools. Besides, this article describes challenges in drug development from marine sources, especially the supply problem.

  12. CDM developer/buyer challenges and opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Weidel, R. [Shell Canada, Calgary, AB (Canada)

    2000-07-01

    Shell Canada's corporate strategy for participating in international efforts in sustainable development through a portfolio approach are discussed. This approach encompasses a mix of sources (in-project energy reductions, offsets via CDM, JI, and emissions trading domestically and internationally), mix of types (resource conservation, renewables, energy efficiency, forestry, carbon sinks) and staggered timing. Some candidate CDM projects in non-Annex 1 countries, such as geothermal energy in Central America, solar home systems in Brazil, replacing coal with natural gas, and solar home systems in South Africa, vent to flare in Malaysia, biomass/photovoltaic applications in the Philippines, and coal replacement with natural gas in China are reviewed. Challenges to developers in terms of host country requirements for approval, the need to control technology and transaction costs, the need to close the gap between carbon dioxide offset and technology cost, ways to share rewards and costs, dealing with language, customs and governmental structures, and realistic requirements, are summarized. As a general rule, the CDM process must reflect the commercial realities of project development, transaction costs must be kept low and there is a need for standardized baselines, especially for small scale projects. Buyers also must be able to deal with certain challenges, such as basic project risk, linkages to business and expertise, risks of measurement and verification, project pricing, and quality of offset. Both developers and buyers, however, share some common objectives in having workable guidelines, simple rules, transparency, efficient, fast track processes, a firm commercial foundation and the desire to close the technology/alternatives gap.

  13. Wildfire Risk Management: Challenges and Opportunities

    Science.gov (United States)

    Thompson, M.; Calkin, D. E.; Hand, M. S.; Kreitler, J.

    2014-12-01

    In this presentation we address federal wildfire risk management largely through the lens of economics, targeting questions related to costs, effectiveness, efficiency, and tradeoffs. Beyond risks to resources and assets such as wildlife habitat, watersheds, and homes, wildfires present financial risk and budgetary instability for federal wildfire management agencies due to highly variable annual suppression costs. Despite its variability, the costs of wildfire management have continued to escalate and account for an ever-growing share of overall agency budgets, compromising abilities to attain other objectives related to forest health, recreation, timber management, etc. Trends associated with a changing climate and human expansion into fire-prone areas could lead to additional suppression costs in the future, only further highlighting the need for an ability to evaluate economic tradeoffs in investments across the wildfire management spectrum. Critically, these economic analyses need to accurately capture the complex spatial and stochastic aspects of wildfire, the inherent uncertainty associated with monetizing environmental impacts of wildfire, the costs and effectiveness of alternative management policies, and linkages between pre-fire investments and active incident management. Investing in hazardous fuels reduction and forest restoration in particular is a major policy lever for pre-fire risk mitigation, and will be a primary focus of our presentation. Evaluating alternative fuel management and suppression policies could provide opportunities for significant efficiency improvements in the development of risk-informed management fire management strategies. Better understanding tradeoffs of fire impacts and costs can help inform policy questions such as how much of the landscape to treat and how to balance investments in treating new areas versus maintaining previous investments. We will summarize current data needs, knowledge gaps, and other factors

  14. Healthcare.gov: Opportunity out of Disaster. Teaching Case

    Science.gov (United States)

    Cundiff, Jacob; McCallum, Taylor; Rich, Andrew; Truax, Michael; Ward, Tamara; Havelka, Douglas

    2015-01-01

    The launch of HealthCare.gov, the website of the Affordable Care Act (AKA Obamacare), was a major public relations disaster for the Obama administration. This case examines some of the factors that contributed to the failure of the launch and then details how Optum, an information technology service provider, considered the opportunity provided by…

  15. Heavy oil transportation - Challenges and opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Gerez, John [Enbridge International (United States)

    2011-07-01

    Enbridge is a leading company in the transportation of oil and gas through pipelines, the company is also active in green energy projects. In North America, Enbridge has built a pipeline which provides the Canadian oil sands with diluent for the production of heavy oil. The heavy oil sector is confronted with technical, social, environmental, regulatory, commercial and diluent supply challenges. With the declining demand in North America, Enbridge has launched a pipeline project to link the Canadian oil sands to Canada's west coast and thereby gain better access to growing markets such as China and India. This project is expected to provide billions of dollars of benefits in the form of provincial and federal revenues and to increase Canada's gross domestic product over the next 30 years. A similar project, Oleoducto al Pacifico, is underway in Colombia to stimulate heavy oil exploration and production by connecting the oil plays to high growth Pacific markets; it is expected to provide long-term economic benefits to the country.

  16. Russian electricity reform. Emerging challenges and opportunities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    The Russian Government is pursuing a strategy of very high economic growth, with the objective of doubling gross domestic product in ten years. It recognises the central role the electricity sector has to play to achieve this target and has embarked on a highly ambitious program of electricity reform. If it is to succeed, the reform program will have to create market structures, market rules and a regulatory framework that will foster competitive wholesale and retail electricity markets. At the same time, it will have to deal with sensitive social issues related to tariff rebalancing and the removal of cross subsidies. Only competitive markets based on transparent prices that reflect costs can deliver the efficient, reliable and internationally competitive performance needed to meet the government's economic targets. Such markets are essential to attract new investment that will be required to ensure security of electricity supply after 2010. This book focuses on key aspects of the proposed reform that could have an important bearing on its success. It also raises concerns as to the pace of reform in related areas, such as the need for complementary reforms in the Russian natural gas sector. The IEA commends the Russian Government on its efforts to embrace this electricity reform - a key element critical to meeting the challenges ahead in terms of its economic growth and energy security. 17 figs., 10 tabs., 3 maps.

  17. Plant growth promoting rhizobia: challenges and opportunities.

    Science.gov (United States)

    Gopalakrishnan, Subramaniam; Sathya, Arumugam; Vijayabharathi, Rajendran; Varshney, Rajeev Kumar; Gowda, C L Laxmipathi; Krishnamurthy, Lakshmanan

    2015-08-01

    Modern agriculture faces challenges, such as loss of soil fertility, fluctuating climatic factors and increasing pathogen and pest attacks. Sustainability and environmental safety of agricultural production relies on eco-friendly approaches like biofertilizers, biopesticides and crop residue return. The multiplicity of beneficial effects of microbial inoculants, particularly plant growth promoters (PGP), emphasizes the need for further strengthening the research and their use in modern agriculture. PGP inhabit the rhizosphere for nutrients from plant root exudates. By reaction, they help in (1) increased plant growth through soil nutrient enrichment by nitrogen fixation, phosphate solubilization, siderophore production and phytohormones production (2) increased plant protection by influencing cellulase, protease, lipase and β-1,3 glucanase productions and enhance plant defense by triggering induced systemic resistance through lipopolysaccharides, flagella, homoserine lactones, acetoin and butanediol against pests and pathogens. In addition, the PGP microbes contain useful variation for tolerating abiotic stresses like extremes of temperature, pH, salinity and drought; heavy metal and pesticide pollution. Seeking such tolerant PGP microbes is expected to offer enhanced plant growth and yield even under a combination of stresses. This review summarizes the PGP related research and its benefits, and highlights the benefits of PGP rhizobia belonging to the family Rhizobiaceae, Phyllobacteriaceae and Bradyrhizobiaceae.

  18. Understanding the Ureter: Challenges and Opportunities.

    Science.gov (United States)

    Park, Alyssa; Venkatesh, Ramakrishna

    2016-05-01

    The ureter is possibly the least studied and most poorly understood organ of the urinary tract. The pathophysiologic basis underlying the use of α-blockers to improve ureteral stone passage or to treat ureteral stent symptoms is poorly understood. This, in part, may explain why clinical studies of medical expulsive therapy for ureteral stone passage are fraught with conflicting data. Methods to study human ureter in vivo are few and challenging. The findings of many of the ureteral studies are from observational in vitro studies and were evaluated in other animal species that may not be applicable in human beings. There are few mechanistic studies evaluating the underlying molecular pathophysiologic mechanisms of human ureter. This is critical to our understanding and treatment of stent symptoms, including the development of a patient friendly ureteral stent and for the pharmacologic modulation of ureteral activity. The following is an overview of some of the observational and mechanistic ureteral studies evaluating the pharmacologic and stent effects, including potential areas for further research.

  19. Home care services for sick children: Healthcare professionals' conceptions of challenges and facilitators.

    Science.gov (United States)

    Castor, Charlotte; Hallström, Inger; Hansson, Helena; Landgren, Kajsa

    2017-09-01

    To explore healthcare professionals' conceptions of caring for sick children in home care services. Families often prefer home care to hospital care, and the number of home care services for children is increasing. Caring for children at home has been recognised as challenging for healthcare professionals in home care services used to providing care predominately for adults. An inductive qualitative design. Seven focus group interviews were performed with 36 healthcare professionals from multidisciplinary home care services. Data were analysed stepwise using a phenomenographic analysis. Three description categories emerged: "A challenging opportunity", "A child perspective", and "Re-organise in accordance with new prerequisites." Providing home care services for children was conceived to evoke both professional and personal challenges such as feelings of inadequacy and fear and professional growth such as increased competence and satisfaction. Conceptions of whether the home or the hospital was the best place for care differed. Adapting to the child's care was conceived as important. Cooperation with paediatric departments and a well-functioning team work were important organisational aspects. Providing home care for children was a challenging but rewarding task for healthcare professionals used to care for adults. To provide care with a child perspective was experienced as important even though there were conflicting conceptions of how this should be done. Close cooperation with paediatric departments and teamwork were prerequisites that make up for the low number of paediatric patients and facilitate confidence and competence. A sufficient number of referred children and enabling healthcare professionals to be part of the re-organising and implementation processes might facilitate the home care services for sick children. Enough time and good teamwork must be emphasised. Early referrals, continuous cooperation with paediatric clinics complemented with

  20. Compost Management in Iran: Opportunities and Challenges

    Directory of Open Access Journals (Sweden)

    Mahdi Farzadkia

    2015-06-01

    Full Text Available Background: According to report of the World Food and Agriculture Organization (FAO, between 33 to 60 percent increase in agricultural production in the world due to the use of chemical fertilizers. Negative effects of fertilizers on the environment and health of living organisms, especially humans, has encountered the country whit challenges such as increasing the number of cancer. Therefore, it is necessary to replace chemical fertilizers whit biofertilizers such as compost. Compost Causes increases in productivity and controls soil erosion. Methods: In order to achieve the objectives of the research, literature review was conducted and to investigate the status of chemical fertilizers and compost in Iran and developed countries through internal and external databases, documents were collected. Results: Use of fertilizers in Europe forecasted to decline 16 million tons in 2030, while in the Iran, rate of fertilizer forecast increases to 6700 thousand tons in 2020. Total supply of compost in the country is 164 thousand tons in 2009 and will be to 590 thousand tons in 2016. The total demand is 472 thousand tons in 2009 and will be to 661 thousand tons in 2016. This indicates that there is 71 thousand tons deficiency in the supply until 2016. Conclusion: Use more of compost in the country, need to a multi-faceted management issue that Ministries, municipalities and recycle of organizations must be working together. Therefore necessary awareness aboute the adverse effects of indiscriminate use of fertilizers and also promote the use compost, in addition to reducing the use of chemical fertilizers, will be cause more demand for consumption of compost.

  1. Post Brexit: challenges and opportunities for radiology beyond the European Union.

    Science.gov (United States)

    Piorkowska, Marta; Goh, Vicky; Booth, Thomas C

    2017-04-01

    We aimed to review the challenges and opportunities that radiology may face once the UK leaves the European Union (EU). Even before the exit negotiations commence, uncertainty over future policies and funding within the UK may influence the National Health Service (NHS). We discuss the potential impact that financial, regulatory and social changes may have on healthcare, and radiology in particular. Current difficulties in recruitment and retention of radiologists and the challenges that Brexit present are considered. Uncertainty over the new immigration regulations and their impact on the NHS workforce is addressed. Challenges also apply to UK research, which has greatly benefited from EU funding and the free movement of staff. Appreciating the problems as well as the opportunities that Brexit presents will help prepare radiology in the UK for the next decade.

  2. Professional development in rural nursing: challenges and opportunities.

    Science.gov (United States)

    McCoy, Cindy

    2009-03-01

    Nurses working in rural settings face challenges not found in urban and suburban areas. These challenges affect nursing care, the nursing profession, and the professional development of the individual nurse. To understand rural nursing, a clear definition of rural nursing and of rural nursing theory is essential. There are many challenges in the rural setting for nursing, particularly regarding enhancement of nurses' professional development. With a clear understanding of rural nursing practice, nurse leaders and educators can work to meet the challenges and embrace the opportunities afforded by nursing in the rural setting.

  3. Big Data Provenance: Challenges, State of the Art and Opportunities.

    Science.gov (United States)

    Wang, Jianwu; Crawl, Daniel; Purawat, Shweta; Nguyen, Mai; Altintas, Ilkay

    2015-01-01

    Ability to track provenance is a key feature of scientific workflows to support data lineage and reproducibility. The challenges that are introduced by the volume, variety and velocity of Big Data, also pose related challenges for provenance and quality of Big Data, defined as veracity. The increasing size and variety of distributed Big Data provenance information bring new technical challenges and opportunities throughout the provenance lifecycle including recording, querying, sharing and utilization. This paper discusses the challenges and opportunities of Big Data provenance related to the veracity of the datasets themselves and the provenance of the analytical processes that analyze these datasets. It also explains our current efforts towards tracking and utilizing Big Data provenance using workflows as a programming model to analyze Big Data.

  4. Community in Online Higher Education: Challenges and Opportunities

    Science.gov (United States)

    Arasaratnam-Smith, Lily A.; Northcote, Maria

    2017-01-01

    Exploring the challenges and opportunities associated with the concepts of community and communication in online higher education, this paper reconsiders the intention to replicate face-to-face learning and teaching strategies in online learning environments. Rather than beginning with the assumption that face-to-face education is the prototype…

  5. Opportunities and challenges in open distance postgraduate student ...

    African Journals Online (AJOL)

    Opportunities and challenges in open distance postgraduate student training in chemistry: Unisa's experience. ... African Journal of Chemical Education ... The Department of Chemistry at the University of South Africa (UNISA) has a proven track record and culture of research and postgraduate student training dating back to ...

  6. Assessment of the Impact of Oil: Opportunities and Challenges for ...

    African Journals Online (AJOL)

    This paper assesses the effect of oil on economic development in Sudan and discusses related opportunities and challenges. We provide a comprehensive analysis using the most recent secondary data, with a view to clarifying the positive and negative effects of oil on Sudan's economic development. We support the view ...

  7. Challenges and Opportunities in Developing Respiratory Syncytial Virus Therapeutics

    NARCIS (Netherlands)

    Simoes, Eric A. F.; DeVincenzo, John P.; Boeckh, Michael; Bont, LJ; Crowe, James E.; Griffiths, Paul; Hayden, Frederick G.; Hodinka, Richard L.; Smyth, Rosalind L.; Spencer, Keith; Thirstrup, Steffen; Walsh, Edward E.; Whitley, Richard J.

    2015-01-01

    Two meetings, one sponsored by the Wellcome Trust in 2012 and the other by the Global Virology Foundation in 2013, assembled academic, public health and pharmaceutical industry experts to assess the challenges and opportunities for developing antivirals for the treatment of respiratory syncytial

  8. Assessment of the Impact of Oil: Opportunities and Challenges for ...

    African Journals Online (AJOL)

    Abstract. This paper assesses the effect of oil on economic development in Sudan and discusses related opportunities and challenges. We provide a comprehensive analysis using the most recent secondary data, with a view to clarifying the positive and negative effects of oil on Sudan's economic development. We support.

  9. Exploring the Opportunities and Challenges of Network Formation ...

    African Journals Online (AJOL)

    Exploring the Opportunities and Challenges of Network Formation for Cooperatives in South Africa. ... KCA Journal of Business Management ... The bulk of studies on networks have largely focused on how resources and capabilities influence inter-organizational linkages that facilitate access to resources embedded in a ...

  10. Status, challenges and marketing opportunities for canning navy ...

    African Journals Online (AJOL)

    Status, challenges and marketing opportunities for canning navy bean in Kenya. ... Inspectorate Service (KEPHIS) for seed inspection and certification, increase in processing capacity, improved breeding and seed production systems and the exploration of new markets coupled with innovative crop promotion stategies.

  11. Challenges and opportunities for quality seed potato availability and ...

    African Journals Online (AJOL)

    Potato yields in Uganda have remained low at 7.5 t ha-1. This low yield is attributed to low yielding varieties, poor management practices and lack of quality seed potatoes among other factors. This study was conducted to ascertain the challenges and opportunities of quality seed potato availability and production in the ...

  12. Alternative Aviation Fuels: Overview of Challenges, Opportunities, and Next Steps

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2017-03-28

    The Alternative Aviation Fuels: Overview of Challenges, Opportunities, and Next Steps report, published by the U.S. Department of Energy’s Bioenergy Technologies Office (BETO) provides an overview of the current state of alternative aviation fuels, based upon findings from recent peer-reviewed studies, scientific working groups, and BETO stakeholder input provided during the Alternative Aviation Fuel Workshop.

  13. the youth and the modern: challenges and opportunities

    African Journals Online (AJOL)

    Every generation has challenges that are specific to the youth and which look modern at the particular time and open up numerous opportunities. In each generation, some people are identified as “leaders” in one of two ways. First, there are those who stand out as “leaders” because they have natural attractions and emit ...

  14. Challenge and Opportunity: the ALI/III Global Principles Project ...

    African Journals Online (AJOL)

    Challenge and Opportunity: the ALI/III Global Principles Project. ... Potchefstroom Electronic Law Journal/Potchefstroomse Elektroniese Regsblad ... This article deals with an international project to establish the extent to which it is feasible to achieve a worldwide acceptance of the Principles of Cooperation among the ...

  15. Scholarship of Teaching International Business: Challenges and Opportunities

    Science.gov (United States)

    Aggarwal, Raj; Goodell, John W.

    2011-01-01

    International business (IB) is an important topic for business schools as business is global, but much business school teaching of IB still seems inadequate. IB education can be challenging but also presents many opportunities. We need to build our knowledge base of effective IB teaching methods and procedures. Such knowledge can not only be used…

  16. Opportunities and Challenges in the Development of Smart PV Systems

    Energy Technology Data Exchange (ETDEWEB)

    Deline, Chris

    2015-06-25

    An update is presented on the background of distributed maximum power point tracking (DMPPT) products, including sub-module power converters, and the performance advantages of distributed (module-level) electronics. Some opportunities and challenges in the field are presented. This presentation was given at the 2015 Trina Solar 'state key laboratory' annual meeting.

  17. South Africa in the BRICS: Opportunities, Challenges and Prospects1

    African Journals Online (AJOL)

    This study investigates the participation of South Africa in the BRICS group from an analytical perspective. It is argued that South Africa's membership to this group entails both opportunities and challenges for South Africa, the continent and the system of global governance. We seek to flesh out the potential mediumand ...

  18. Workplace Diversity and Public Policy: Challenges and Opportunities for Psychology

    Science.gov (United States)

    Fassinger, Ruth E.

    2008-01-01

    This article outlines both challenges and opportunities for psychology of issues related to diversity in education and work. For the purposes of this discussion, "diverse" populations include four groups currently marginalized and disadvantaged in the U.S. workplace: women, people of color, sexual minorities, and people with disabilities. An…

  19. Issues, challenges and opportunities related to gender and livestock ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-06-06

    Jun 6, 2016 ... Read more in the Gender and Livestock: Issues, Challenges and Opportunities brief (PDF, 726KB, available in English only). This document summarizes findings presented in the book “Women, Livestock Ownership and Markets: Bridging the Gender Gap in Eastern and Southern Africa” produced by the ...

  20. Human Resource Development in Mauritius: Context, Challenges and Opportunities

    Science.gov (United States)

    Garavan, Thomas N.; Neeliah, Harris; Auckloo, Raj; Ragaven, Raj

    2016-01-01

    Purpose: The purpose of this paper is to explore human resource development (HRD) in Mauritius and the challenges and opportunities faced by organisations in different sectors in adopting HRD practices. Findings: This special issue presents four papers that explore dimensions of HRD in public sector, small- and medium-sized enterprises (SMEs) and…

  1. Small reactors in the Canadian context: opportunities and challenges

    Energy Technology Data Exchange (ETDEWEB)

    Walker, R.S. [Atomic Energy of Canada Limited, Chalk River, Ontario (Canada)

    2013-07-01

    This presentation discusses the opportunities and challenges for small reactors in Canada. It concludes by suggesting that the success of small reactors in Canada will depend on a number of factors including private sector investment, access to international markets, stable, equitable and adaptable regulatory regime, public trust and technology.

  2. Current opportunities and challenges in skeletal muscle tissue engineering

    NARCIS (Netherlands)

    Koning, Merel; Harmsen, Martin C; van Luyn, Marja J A; Werker, Paul M N

    The purpose of this article is to give a concise review of the current state of the art in tissue engineering (TE) of skeletal muscle and the opportunities and challenges for future clinical applicability. The endogenous progenitor cells of skeletal muscle, i.e. satellite cells, show a high

  3. Challenges and opportunities for korean missionaries in Southern ...

    African Journals Online (AJOL)

    This article describes the history of missions in Korea as well as the challenges and opportunities for Korean missionaries in Southern Africa. The most signifi cant problems encountered by Korean missionaries include understanding local context, language and culture acquisition, and meeting the expectations of local ...

  4. Facebook: Challenges and Opportunities for Business Communication Students

    Science.gov (United States)

    Decarie, Christina

    2010-01-01

    In this article, the author describes her experience with networking on Facebook and discusses some important challenges and opportunities for business communication students. Facebook requires and enhances strong writing and interpersonal communication skills and it requires something new--a kind of literacy that students and teachers alike are…

  5. Teaching Culture: The Challenges and Opportunities of International Public Relations.

    Science.gov (United States)

    George, Amiso M.

    2003-01-01

    Focuses on the challenges and opportunities for international public relations practice. Looks at current United States-Arab relations issues in international crisis communication. Discusses those issues, especially the role of culture and media. Proposes strategies including a case study that teachers can use to help students become effective…

  6. Capturing opportunities and meeting challenges in radiation protection.

    Science.gov (United States)

    Kase, Kenneth R

    2015-02-01

    This summary of the 2014 Annual Meeting of the National Council on Radiation Protection and Measurement (NCRP) captures the opportunities presented during the Warren K. Sinclair Keynote Address, the Lauriston S. Taylor Lecture, and the six scientific sessions including the subsequent questions and answers. It captures the important issues that emerge in these opportunities and discusses the challenges that they bring to radiation protection. These opportunities arise in the basic sciences; in operational areas such as emerging technologies, preparing for the improbable but possible event, industry and medicine; and in education, communication and policy. The challenges include identifying the most important aspects of radiation protection and measurement, prioritizing them in accordance with the NCRP mission, and gaining support for the activities of the NCRP to address these issues in the fulfillment of its charter.

  7. Mobile computing in medical education: opportunities and challenges.

    Science.gov (United States)

    Chu, Larry F; Erlendson, Matthew J; Sun, John S; Alva, Heather L; Clemenson, Anna M

    2012-12-01

    There is an increasing importance of incorporating mobile computing into the academic medical environment. A growing majority of physicians, residents and medical students currently use mobile devices for education, access to clinical information and to facilitate bedside care. Therefore, it is important to assess the current opportunities and challenges in the use of mobile computing devices in the academic medical environment. Current research has found that a majority of physicians, residents and medical students either own or use mobile devices. In addition, studies have shown that these devices are effective as educational tools, resource guides and aids in patient care. Although there are opportunities for medical education, issues of deployment must still be addressed, such as privacy, connectivity, standardization and professionalism. Understanding the opportunities and challenges of using mobile computing devices in the academic medical environment can help determine the feasibility and benefits of their use for individuals and institutions.

  8. Postpolio syndrome: a challenge to the health-care system.

    Science.gov (United States)

    Bouza, Carmen; Muñoz, Ana; Amate, José María

    2005-01-01

    The practical eradication of poliomyelitis in industrialized countries marks one of the most important achievements of world health policy. Yet, disability induced by polio not only continues to exist among survivors with paralytic sequelae, but may also be further accentuated in a considerable number of affected subjects by the development of postpolio syndrome (PPS). PPS aggravates the motor sequelae already present in such subjects and reduces their functional capacity to the point where it affects their activities of daily living and worsens their quality of life. Inasmuch as development of PPS questions the concept of poliomyelitis as a static disease it poses a challenge not only to health professionals but also to policy-makers tasked with providing the necessary health-care measures and appropriate resources. This study sought to review research on this syndrome and to draw up some recommendations that might prove useful to the health authorities for decision-making purposes.

  9. Opportunities and challenges for statistics education in South Africa

    Directory of Open Access Journals (Sweden)

    Temesgen Zewotir

    2011-11-01

    Full Text Available The South African educational system is in a state of transformation as the Government embarks on a process of grappling with legacies of the past, whilst balancing risks and opportunities for the future. Accordingly, a new school curriculum with outcomes-based education as the fundamental building block was introduced along a sliding scale, starting in 1997. This curriculum, with a vast statistics content, has the potential to change the face of statistics education in South Africa, as statistics had previously been virtually absent from the school syllabus. This article highlights the challenges to and opportunities for optimising the teaching of statistics across all education levels in South Africa.

  10. [The opportunities and challenges of nursing professional development: celebrating 100 years of nursing in Taiwan].

    Science.gov (United States)

    Tsay, Shwu-Feng

    2011-06-01

    This article used both retrospective and prospective perspectives to rethink and reflect upon the opportunities and challenges of nursing professional development in Taiwan. The authors conducted a literature review on the 2011-2015 Strategic Directions for Strengthening Nursing and Midwifery Services (SDNM) initiated by the World Health Organization (WHO) and on analyses of nursing related polices and programs from done by Taiwan health administrative offices. It is important to record the contribution of nursing to Taiwan's healthcare delivery system. Such is especially in light of the Taiwan's centenary celebrations in 2011 and of the Department of Health's consolidation into the Ministry of Health and Welfare in 2012 due to central government reforms.

  11. Urban underground logistics system in China: Opportunities or challenges?

    Directory of Open Access Journals (Sweden)

    Zhilong Chen

    2017-09-01

    Full Text Available An urban underground logistics system (ULS is one important means of solving urban traffic problems that has unique advantages. Freight transportation in China requires a new transportation mode. Therefore, ULS has garnered increasing attention. However, to date, few scholars and practitioners have investigated ULS in China. Although ULS shows good development opportunities, it also faces great challenges. Based on the Macro-environment and situation analysis (PEST-SWOT model, which is a strategic analysis method that combines both SWOT and PEST to effectively identify advantages, disadvantages, opportunities and threats, this paper first uses PEST to analyze the macro-environment of ULS in China and identify its internal factors (i.e., advantages and disadvantages and external factors (i.e., opportunities and threats. Next, based on the SWOT framework, this paper proposes several development strategies and recommendations that provide a comprehensive and novel perspective to the study of ULS in China.

  12. From mobile mental health to mobile wellbeing: opportunities and challenges.

    Science.gov (United States)

    Gaggioli, Andrea; Riva, Giuseppe

    2013-01-01

    The combination of smart phones, wearable sensor devices and social media offer new ways of monitoring and promoting mental and physical wellbeing. In this contribution, we describe recent developments in the field of mobile healthcare (or mHealth), by focusing in particular on mobile mental health applications. First, we examine the potential benefits associated with this approach, providing examples from existing projects. Next, we identify and explain possible differences in focus between mobile mental health and mobile wellbeing applications. Finally, we discuss some open challenges associated with the implementation of this vision, ranging from the lack of evidence-based validation to privacy, security and ethical concerns.

  13. Processing Challenges and Opportunities of Camel Dairy Products

    DEFF Research Database (Denmark)

    Berhe, Tesfemariam; Seifu, Eyassu; Ipsen, Richard

    2017-01-01

    to bovine milk. Nonetheless, the relative composition, distribution, and the molecular structure of the milk components are reported to be different. Consequently, manufacturing of camel dairy products such as cheese, yoghurt, or butter using the same technology as for dairy products from bovine milk can......A review on the challenges and opportunities of processing camel milk into dairy products is provided with an objective of exploring the challenges of processing and assessing the opportunities for developing functional products from camel milk. The gross composition of camel milk is similar...... result in processing difficulties and products of inferior quality. However, scientific evidence points to the possibility of transforming camel milk into products by optimization of the processing parameters. Additionally, camel milk has traditionally been used for its medicinal values and recent...

  14. [The opportunities, challenges and trends in the rejuvenation of microbiology].

    Science.gov (United States)

    Shen, Ping; Chen, Xiangdong

    2010-01-01

    In history, the development of microbiology had undergone two golden ages and some depression time as well. In the last two decades, the application of many physiochemical technologies including genomics, structural biology, bioinformatics, PCR, and high-resolution microscopy has led to a series of breakthroughs in microbiology. Microbiology has now awakened and entered its third golden age for development. This review discusses our view of the opportunities, challenges, and trends in the current advancement of microbiology. The topics include: (1) The two golden ages for microbiology in history. (2) The opportunities and challenges in the rejuvenation of microbiology. (3) The characteristics and trends of the current development of microbiology. (4) Integral microbiology--the hallmark of the third golden age.

  15. The Opportunity and Challenge of The Age of Big Data

    Science.gov (United States)

    Yunguo, Hong

    2017-11-01

    The arrival of large data age has gradually expanded the scale of information industry in China, which has created favorable conditions for the expansion of information technology and computer network. Based on big data the computer system service function is becoming more and more perfect, and the efficiency of data processing in the system is improving, which provides important guarantee for the implementation of production plan in various industries. At the same time, the rapid development of fields such as Internet of things, social tools, cloud computing and the widen of information channel, these make the amount of data is increase, expand the influence range of the age of big data, we need to take the opportunities and challenges of the age of big data correctly, use data information resources effectively. Based on this, this paper will study the opportunities and challenges of the era of large data.

  16. Challenges and opportunities for Korean missionaries in Southern Africa

    Directory of Open Access Journals (Sweden)

    Kyung H. Oh

    2009-03-01

    Full Text Available This article describes the history of missions in Korea as well as the challenges and opportunities for Korean missionaries in Southern Africa. The most significant problems encountered by Korean missionaries include understanding local context, language and culture acquisition, and meeting the expectations of local people and local churches as well as those of sending churches in Korea. On a personal level, missionaries have to cope with family concerns, maintaining their spiritual life, health problems, financial concerns, frustrations and unfulfilled ideals. Korean missionaries in Southern Africa do, however, have a unique opportunity to serve the Church in its mission and, above all, to serve the Lord of the Church in his mission, although there are indeed difficulties to overcome and challenges to face.

  17. Challenges and opportunities for Korean missionaries in Southern Africa

    Directory of Open Access Journals (Sweden)

    Kyung H. Oh

    2009-05-01

    Full Text Available This article describes the history of missions in Korea as well as the challenges and opportunities for Korean missionaries in Southern Africa. The most significant problems encountered by Korean missionaries include understanding local context, language and culture acquisition, and meeting the expectations of local people and local churches as well as those of sending churches in Korea. On a personal level, missionaries have to cope with family concerns, maintaining their spiritual life, health problems, financial concerns, frustrations and unfulfilled ideals. Korean missionaries in Southern Africa do, however, have a unique opportunity to serve the Church in its mission and, above all, to serve the Lord of the Church in his mission, although there are indeed difficulties to overcome and challenges to face.

  18. Revenue generation in the information era: Opportunities and challenges

    Directory of Open Access Journals (Sweden)

    Sreelata Jonnalagedda

    2011-03-01

    Full Text Available In an information economy, innovative revenue generating models are as critical for the sustenance of a firm as is bringing cutting edge technology to the market. In its first part, this article surveys the characteristics of the information goods market and identifies the opportunities and challenges that the information era presents. Further, it surveys the existing business models for information goods and maps them to the market characteristics to arrive at the viability of these models. The second part of the article presents the views and experiences of a panel of practitioners who face these challenges in the field of information goods.

  19. Developing URBAN RENEWABLE ENERGY PROJECTS: OPPORTUNITIES AND CHALLENGES FOR ROMANIA

    OpenAIRE

    Andreea ZAMFIR

    2014-01-01

    This study investigates the public authorities support for the development of renewable energy projects, with an eye to reveal a change of paradigm, in the sense that their role is currently reconsidered and intensified. Therefore, this study reveals firstly the responsibility of the public authorities in the field of renewable energy, and secondly, the main aspects of the public policy in the field of renewable energy, together with its opportunities, challenges and possible solutions. Third...

  20. Challenges and Opportunities of Grid Modernization and Electric Transportation

    Energy Technology Data Exchange (ETDEWEB)

    Graham, Robert L. [Dept. of Energy (DOE), Washington DC (United States); Francis, Julieta [Allegheny Science and Technology, Bridgeport, WV (United States); Bogacz, Richard J. [Allegheny Science and Technology, Bridgeport, WV (United States)

    2017-03-31

    Grid investments that support electric vehicle deployments as a part of planned modernization efforts can enable a more efficient and cost-effective transition to electric transportation and allow investor-owned electric companies and public power companies to realize new revenue resources in times of flat or declining loads. This paper discusses the challenges and opportunities associated with an increase in plug-in electric vehicle (PEV) adoption and how working together both sectors stand to benefit from closer integration.

  1. Guest Editorial: Women's rights and children's rights: challenges and opportunities

    OpenAIRE

    Judith Evans

    2001-01-01

    Judith L. Evans introduces the journal's themes looking at the significant linkages between women's rights and children's rights. Evans argues that the two sets of rights together need to be brought forward, looking at the way they are interlinked through two conventions – CRC and CEDAW – developed in the 1990s. She presents some of the challenges and opportunities that a simultaneous focus on women's and children's rights presents in terms of development work. Development (2001) 44, 7–14. do...

  2. Communication technology and social media: opportunities and implications for healthcare systems.

    Science.gov (United States)

    Weaver, Betsy; Lindsay, Bill; Gitelman, Betsy

    2012-09-30

    Electronic patient education and communications, such as email, text messaging, and social media, are on the rise in healthcare today. This article explores potential uses of technology to seek solutions in healthcare for such challenges as modifying behaviors related to chronic conditions, improving efficiency, and decreasing costs. A brief discussion highlights the role of technologies in healthcare informatics and considers two theoretical bases for technology implementation. Discussion focuses more extensively on the ability and advantages of electronic communication technology, such as e-mail, social media, text messaging, and electronic health records, to enhance patient-provider e-communications in nursing today. Effectiveness of e-communication in healthcare is explored, including recent and emerging applications designed to improve patient-provider connections and review of current evidence supporting positive outcomes. The conclusion addresses the vision of nurses' place in the vanguard of these developments.

  3. Using time-driven activity-based costing to identify value improvement opportunities in healthcare.

    Science.gov (United States)

    Kaplan, Robert S; Witkowski, Mary; Abbott, Megan; Guzman, Alexis Barboza; Higgins, Laurence D; Meara, John G; Padden, Erin; Shah, Apurva S; Waters, Peter; Weidemeier, Marco; Wertheimer, Sam; Feeley, Thomas W

    2014-01-01

    As healthcare providers cope with pricing pressures and increased accountability for performance, they should be rededicating themselves to improving the value they deliver to their patients: better outcomes and lower costs. Time-driven activity-based costing offers the potential for clinicians to redesign their care processes toward that end. This costing approach, however, is new to healthcare and has not yet been systematically implemented and evaluated. This article describes early time-driven activity-based costing work at several leading healthcare organizations in the United States and Europe. It identifies the opportunities they found to improve value for patients and demonstrates how this costing method can serve as the foundation for new bundled payment reimbursement approaches.

  4. Qualitative research in rehabilitation science: opportunities, challenges, and future directions.

    Science.gov (United States)

    VanderKaay, Sandra; Moll, Sandra E; Gewurtz, Rebecca E; Jindal, Pranay; Loyola-Sanchez, Adalberto; Packham, Tara L; Lim, Chun Y

    2018-03-01

    Qualitative research has had a significant impact within rehabilitation science over time. During the past 20 years the number of qualitative studies published per year in Disability and Rehabilitation has markedly increased (from 1 to 54). In addition, during this period there have been significant changes in how qualitative research is conceptualized, conducted, and utilized to advance the field of rehabilitation. The purpose of this article is to reflect upon the progress of qualitative research within rehabilitation to date, to explicate current opportunities and challenges, and to suggest future directions to continue to strengthen the contribution of qualitative research in this field. Relevant literature searches were conducted in electronic data bases and reference lists. Pertinent literature was examined to identify current opportunities and challenges for qualitative research use in rehabilitation and to identify future directions. Six key areas of opportunity and challenge were identified: (a) paradigm shifts, (b) advancements in methodology, (c) emerging technology, (d) advances in quality evaluation, (e) increasing popularity of mixed methods approaches, and (f) evolving approaches to knowledge translation. Two important future directions for rehabilitation are posited: (1) advanced training in qualitative methods and (2) engaging qualitative communities of research. Qualitative research is well established in rehabilitation and has an important place in the continued growth of this field. Ongoing development of qualitative researchers and methods are essential. Implications for Rehabilitation Qualitative research has the potential to improve rehabilitation practice by addressing some of the most pervasive concerns in the field such as practitioner-client interaction, the subjective and lived experience of disability, and clinical reasoning and decision making. This will serve to better inform those providing rehabilitation services thereby benefiting

  5. Levinas's ethics as a basis of healthcare - challenges and dilemmas.

    Science.gov (United States)

    Nordtug, Birgit

    2015-01-01

    Levinas's ethics has in the last decades exerted a significant influence on Nursing and Caring Science. The core of Levinas's ethics - his analyses of how our subjectivity is established in the ethical encounter with our neighbour or the Other - is applied both to healthcare practice and in the project of building an identity of Nursing and Caring Science. Levinas's analyses are highly abstract and metaphysical, and also non-normative. Thus, his analyses cannot be applied directly to practical problems and questions. Theorists in Nursing and Caring Science are generally aware of this. Nevertheless, many of them use Levinas's analyses to explore and solve questions of practical and normative character. This article focuses on the challenges and dilemmas of using Levinas in this manner. The article is divided into two parts. The first part presents some central ideas of Levinas's ethics based on the latter part of his authorship. The main focus is on the radicalism of Levinas's critique of the symbolic order (which includes concepts, categories, knowledge, etc.) - or as he puts it 'the said' - as a basis for subjectivity and responsibility. Levinas's notions of saying, anarchy, and singularity accentuate this point of view. These notions refer to conditions in the language, which counteract the symbolic order in the ethical encounter to such an extent that it becomes an incomprehensible. Levinas gives the argumentation a metaphysical frame: The encounter with the incomprehensible is an encounter with the Holy, which is not the ontological God, but a metaphysical desire. It is a mystery as to what this means, and herein lies possibly the main challenge when using Levinas's ethics in science and research: How to maintain the radicalism of his critique of the symbolic order when this is to be communicated in a scientific context that expects clarification of statements and ideas? The second part of the article explores this question by examining how some theorists use

  6. Financing dengue vaccine introduction in the Americas: challenges and opportunities.

    Science.gov (United States)

    Constenla, Dagna; Clark, Samantha

    2016-01-01

    Dengue has escalated in the region of the Americas unabated despite major investments in integrated vector control and prevention strategies. An effective and affordable dengue vaccine can play a critical role in reducing the human and economic costs of the disease by preventing millions around the world from getting sick. However, there are considerable challenges on the path towards vaccine introduction. These include lack of sufficient financing tools, absence of capacity within national level decision-making bodies, and demands that new vaccines place on stressed health systems. Various financing models can be used to overcome these challenges including setting up procurement mechanisms, integrating regional and domestic taxes, and setting up low interest multilateral loans. In this paper we review these challenges and opportunities of financing dengue vaccine introduction in the Americas.

  7. Challenges and opportunities associated with waste management in India

    Science.gov (United States)

    Kumar, Sunil; Smith, Stephen R.; Fowler, Geoff; Velis, Costas; Kumar, S. Jyoti; Arya, Shashi; Rena; Kumar, Rakesh

    2017-01-01

    India faces major environmental challenges associated with waste generation and inadequate waste collection, transport, treatment and disposal. Current systems in India cannot cope with the volumes of waste generated by an increasing urban population, and this impacts on the environment and public health. The challenges and barriers are significant, but so are the opportunities. This paper reports on an international seminar on ‘Sustainable solid waste management for cities: opportunities in South Asian Association for Regional Cooperation (SAARC) countries’ organized by the Council of Scientific and Industrial Research-National Environmental Engineering Research Institute and the Royal Society. A priority is to move from reliance on waste dumps that offer no environmental protection, to waste management systems that retain useful resources within the economy. Waste segregation at source and use of specialized waste processing facilities to separate recyclable materials has a key role. Disposal of residual waste after extraction of material resources needs engineered landfill sites and/or investment in waste-to-energy facilities. The potential for energy generation from landfill via methane extraction or thermal treatment is a major opportunity, but a key barrier is the shortage of qualified engineers and environmental professionals with the experience to deliver improved waste management systems in India. PMID:28405362

  8. Iterative near-term ecological forecasting: Needs, opportunities, and challenges.

    Science.gov (United States)

    Dietze, Michael C; Fox, Andrew; Beck-Johnson, Lindsay M; Betancourt, Julio L; Hooten, Mevin B; Jarnevich, Catherine S; Keitt, Timothy H; Kenney, Melissa A; Laney, Christine M; Larsen, Laurel G; Loescher, Henry W; Lunch, Claire K; Pijanowski, Bryan C; Randerson, James T; Read, Emily K; Tredennick, Andrew T; Vargas, Rodrigo; Weathers, Kathleen C; White, Ethan P

    2018-02-13

    Two foundational questions about sustainability are "How are ecosystems and the services they provide going to change in the future?" and "How do human decisions affect these trajectories?" Answering these questions requires an ability to forecast ecological processes. Unfortunately, most ecological forecasts focus on centennial-scale climate responses, therefore neither meeting the needs of near-term (daily to decadal) environmental decision-making nor allowing comparison of specific, quantitative predictions to new observational data, one of the strongest tests of scientific theory. Near-term forecasts provide the opportunity to iteratively cycle between performing analyses and updating predictions in light of new evidence. This iterative process of gaining feedback, building experience, and correcting models and methods is critical for improving forecasts. Iterative, near-term forecasting will accelerate ecological research, make it more relevant to society, and inform sustainable decision-making under high uncertainty and adaptive management. Here, we identify the immediate scientific and societal needs, opportunities, and challenges for iterative near-term ecological forecasting. Over the past decade, data volume, variety, and accessibility have greatly increased, but challenges remain in interoperability, latency, and uncertainty quantification. Similarly, ecologists have made considerable advances in applying computational, informatic, and statistical methods, but opportunities exist for improving forecast-specific theory, methods, and cyberinfrastructure. Effective forecasting will also require changes in scientific training, culture, and institutions. The need to start forecasting is now; the time for making ecology more predictive is here, and learning by doing is the fastest route to drive the science forward.

  9. Wastewater reclamation and reuse in China: Opportunities and challenges.

    Science.gov (United States)

    Lyu, Sidan; Chen, Weiping; Zhang, Weiling; Fan, Yupeng; Jiao, Wentao

    2016-01-01

    The growing water stress both in terms of water scarcity and quality deterioration promotes the development of reclaimed water as a new water resource use. This paper reviewed wastewater reuse practices in China, and the opportunities and challenges of expanding reclaimed water use were analyzed. Rapid urbanization with the increasing of water demand and wastewater discharge provides an opportunity for wastewater reuse. The vast amount of wastewater discharge and low reclaimed water production mean that wastewater reuse still has a great potential in China. Many environmental and economic benefits and successful reclamation technologies also provide opportunities for wastewater reuse. In addition, the overall strategy in China is also encouraging for wastewater reuse. In the beginning stage of wastewater reclamation and reuse, there are many significant challenges to expand wastewater reuse in China including slow pace in adopting urban wastewater reuse programs, the establishment of integrated water resources management framework and guidelines for wastewater reuse programs, incoherent water quality requirements, the limited commercial development of reclaimed water and the strengthening of public awareness and cooperation among stakeholders. Copyright © 2015. Published by Elsevier B.V.

  10. Viral hepatitis and immigration: A challenge for the healthcare system.

    Science.gov (United States)

    Cuenca-Gómez, J A; Salas-Coronas, J; Soriano-Pérez, M J; Vázquez-Villegas, J; Lozano-Serrano, A B; Cabezas-Fernández, M T

    2016-01-01

    Viral hepatitis is a significant health problem in African countries. The increase in the immigrant population from this continent represents a challenge for the Spanish healthcare system. A descriptive study was conducted on the prevalence of the serological markers of hepatitis B (HBV), C (HCV) and D (HDV) in African immigrants treated in a specialised doctor's office. The study included 2518 patients (87.7% Sub-Saharan natives), with a mean age of 31.3 years. Some 78.8% of the patients had a positive infection marker for HBV, and 638 patients (25.3%) were diagnosed with active hepatitis B (HBsAg +). In 19 cases, antibodies against HDV were detected (4 cases with detection of the viral genome). Sixty-eight patients had antibodies against HCV, 26 of whom had a positive viral load. The high prevalence of viral hepatitis in immigrants, especially HBV infection, represents a significant change in the profile of patients treated in Spain and requires measures aimed at early diagnosis and transmission prevention. Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.

  11. Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications.

    Science.gov (United States)

    Wicki, Andreas; Witzigmann, Dominik; Balasubramanian, Vimalkumar; Huwyler, Jörg

    2015-02-28

    Cancer is a leading cause of death worldwide. Currently available therapies are inadequate and spur demand for improved technologies. Rapid growth in nanotechnology towards the development of nanomedicine products holds great promise to improve therapeutic strategies against cancer. Nanomedicine products represent an opportunity to achieve sophisticated targeting strategies and multi-functionality. They can improve the pharmacokinetic and pharmacodynamic profiles of conventional therapeutics and may thus optimize the efficacy of existing anti-cancer compounds. In this review, we discuss state-of-the-art nanoparticles and targeted systems that have been investigated in clinical studies. We emphasize the challenges faced in using nanomedicine products and translating them from a preclinical level to the clinical setting. Additionally, we cover aspects of nanocarrier engineering that may open up new opportunities for nanomedicine products in the clinic. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. Multiple identities in social perception and interaction: challenges and opportunities.

    Science.gov (United States)

    Kang, Sonia K; Bodenhausen, Galen V

    2015-01-03

    Categorization plays a fundamental role in organizing daily interactions with the social world. However, there is increasing recognition that social categorization is often complex, both because category membership can be ambiguous (e.g., multiracial or transgender identities) and because different categorical identities (e.g., race and gender) may interact to determine the meaning of category membership. These complex identities simultaneously impact social perceivers' impressions and social targets' own experiences of identity, thereby shaping perceptions, experiences, and interactions in fundamental ways. This review examines recent research on the perception and experience of the complex, multifaceted identities that both complicate and enrich our lives. Although research has historically tended to focus more on difficulties and challenges associated with multiple identities, increasing attention is being paid to opportunities that emerge from the possession of identities that include multiple distinct or overlapping groups. We consider how these opportunities might benefit both perceivers and targets.

  13. Opportunities and challenges in developing gas markets in South America

    Energy Technology Data Exchange (ETDEWEB)

    Duarte, Cristiano Boaventura [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil)

    2008-07-01

    The article has the objective of identifying and analyzing the key market levers and drivers, emerging issues and challenges in developing the gas markets in South America. In section 1, the paper provides an overview of the most relevant indicators in the natural gas markets of the region. Data such as natural gas proven reserves; production; consumption; trade movements (by pipeline and LNG) and main aspects of regulatory framework are shown. In section 2, some of the key challenges and opportunities in developing gas markets in the region are identified, including those relating to market integration, political aspects and the main players' investments. In section 3, possible strategies from governments and enterprises to overcome those challenges, and seize the potential opportunities of the region are examined. In section 4, the conclusions point to the potential of developing the gas markets as a means to diversify the energy sources in the region, fostering a successful process of economic growth and political integration in the area. (author)

  14. Urbanization in Africa: challenges and opportunities for conservation

    Science.gov (United States)

    Güneralp, Burak; Lwasa, Shuaib; Masundire, Hillary; Parnell, Susan; Seto, Karen C.

    2017-12-01

    Africa, a continent exceptionally rich in biodiversity, is rapidly urbanizing. Africa’s urbanization is manifest in the growth of its megacities as well as that of its smaller towns and cities. The conservation planning and practice will increasingly need to account for direct and indirect impacts of the continent’s urbanization. The objective of our study is to pinpoint the outstanding challenges and opportunities afforded by the growing cities on the continent to the conservation goals and practices. While there have been many studies on the impacts of urbanization and development on conservation in Africa these studies tended to focus on specific issues. Here, we provide a synthesis of this body of work supported by new analysis. Urban areas, growing both in population and in land cover, pose threats to the integrity of the continent’s ecosystems and biodiversity but their growth also create opportunities for conservation. The burgeoning urban populations, especially in Sub-Saharan Africa, increase the strain on already insufficient infrastructure and bring new governance challenges. Yet, Africa’s ecosystems can serve as foundations for green infrastructure to serve the needs of its urban populations while safeguarding fragile biodiversity. Overall, while worsening social problems overshadow the concerns for biodiversity there are also promising initiatives to bring these concerns into the fold to address social, institutional, and ecological challenges that emerge with the continued urbanization of the continent.

  15. Challenges and opportunities for characterizing cognitive aging across species.

    Science.gov (United States)

    Roberson, Erik D; Defazio, R Anthony; Barnes, Carol A; Alexander, Gene E; Bizon, Jennifer L; Bowers, Dawn; Foster, Thomas C; Glisky, Elizabeth L; Levin, Bonnie E; Ryan, Lee; Wright, Clinton B; Geldmacher, David S

    2012-01-01

    The gradual decline of cognitive ability with age, even in the absence of overt brain disease, is a growing problem. Although cognitive aging is a common and feared accompaniment of the aging process, its underlying mechanisms are not well understood and there are no highly effective means to prevent it. Additional research on cognitive aging is sorely needed, and methods that enable ready translation between human subjects and animal models stand to provide the most benefit. Here and in the six companion pieces in this special issue, we discuss a variety of challenges and opportunities for studying cognitive aging across species. We identify tests of associative memory, recognition memory, spatial and contextual memory, and working memory and executive function as cognitive domains that are age-sensitive and amenable to testing with parallel means in both humans and animal models. We summarize some of the important challenges in using animal models to test cognition. We describe unique opportunities to study cognitive aging in human subjects, such as those provided by recent large-scale initiatives to characterize cognition in large groups of subjects across the lifespan. Finally, we highlight some of the challenges of studying cognitive aging in human subjects.

  16. Challenges and Opportunities for Characterizing Cognitive Aging across Species

    Directory of Open Access Journals (Sweden)

    Erik D Roberson

    2012-09-01

    Full Text Available The gradual decline of cognitive ability with age, even in the absence of overt brain disease, is a growing problem. Although cognitive aging is a common and feared accompaniment of the aging process, its underlying mechanisms are not well understood and there are no highly effective means to prevent it. Additional research on cognitive aging is sorely needed, and methods that enable ready translation between human subjects and animal models stand to provide the most benefit. Here and in the six companion pieces in this special issue, we discuss a variety of challenges and opportunities for studying cognitive aging across species. We identify tests of associative memory, recognition memory, spatial and contextual memory, and working memory and executive function as cognitive domains that are age-sensitive and amenable to testing with parallel means in both humans and animal models. We summarize some of the important challenges in using animal models to test cognition. We describe unique opportunities to study cognitive aging in human subjects, such as those provided by recent large-scale initiatives to characterize cognition in large groups of subjects across the lifespan. Finally, we highlight some of the challenges of studying cognitive aging in human subjects.

  17. Rainwater harvesting in South Africa: Challenges and opportunities

    Science.gov (United States)

    Mwenge Kahinda, J.; Taigbenu, A. E.

    Water paucity remains a major threat to poverty, hunger alleviation as well as sustainable development. Innovative water technologies such as rainwater harvesting (RWH) have the potential to improve rural water supply and contribute to the provision of the first 6 kl of water consumed monthly. RWH can also be the solution to South Africa food security by increasing water productivity of dryland agriculture and enabling homestead gardening. Although used for decades in South Africa, rainwater harvesting (RWH) is still far from being utilised to its full potential as unresolved challenges prevent its wide scale adoption. The paper presents the challenges and opportunities to the upscaling of RWH in South Africa. Key challenges preventing the nationwide expansion of RWH are the current water related legislations, the lack of finances and the absence of a national umbrella body that coordinates. While opportunities lie in the worth of knowledge gathered by research projects, funded over the last two decades, on the biophysical and socio-economic impacts of RWH.

  18. Medical doctors in healthcare leadership: theoretical and practical challenges.

    Science.gov (United States)

    Denis, Jean-Louis; van Gestel, Nicolette

    2016-05-24

    While healthcare systems vary in their structure and available resources, it is widely recognized that medical doctors play a key role in their adaptation and performance. In this article, we examine recent government and organizational policies in two different health systems that aim to develop clinical leadership among the medical profession. Clinical leadership refers to the engagement and guiding role of physicians in health system improvement. Three dimensions are defined to conduct our analysis of engaging medical doctors in healthcare leadership: the position and status of medical doctors within the system; the broader institutional context of governmental and organizational policies to engage medical doctors in clinical leadership roles; and the main factors that may facilitate or limit achievements. Our aim in this study is exploratory. We selected two contrasting cases according to their level of institutional pluralism: one national health insurance system, Canada, and one etatist social insurance system, the Netherlands. We documented the institutional dynamics of medical doctors' engagement and leadership through secondary sources, such as government websites, key policy reports, and scholarly literature on health policies in both countries. Initiatives across Canadian provinces signal that the medical profession and governments search for alternatives to involve doctors in health system improvement beyond the limitations imposed by their fundamental social contract and formal labour relations. These initiatives suggest an emerging trend toward more joint collaboration between governments and medical associations. In the Dutch system, organizational and legal attempts for integration over the past decades do not yet fit well with the ideas and interests of medical doctors. The engagement of medical doctors requires additional initiatives that are closer to their professional values and interests and that depart from an overly focus on top down

  19. Qualitative assessment of HIV prevention challenges and opportunities among Latino immigrant men in a new receiving city.

    Science.gov (United States)

    Dolwick Grieb, Suzanne M; Desir, Fidel; Flores-Miller, Alejandra; Page, Kathleen

    2015-02-01

    Changing demographics in new receiving communities contributes to a lag time between the arrival of new immigrants and the development of appropriate services. This scarcity of services can exacerbate existing disparities in health conditions such as HIV, which disproportionately affects Latinos. Focus groups were conducted in Baltimore with 59 Latino men who had immigrated to the U.S. within the past 10 years to explore the challenges and opportunities to accessing HIV testing and preventative services. Transcripts were analyzed through a modified thematic constant comparison approach. Four thematic categories emerged: information about HIV, HIV fear and stigma, barriers to accessing healthcare, and opportunities for intervention approaches. Information and communication technology provides an opportunity to improve access to HIV testing and prevention services. Individualized interventions, though, must be disseminated in collaboration with community-, structural-, and policy-level interventions that address HIV risk, HIV/AIDS stigma, and healthcare access among Latino immigrants.

  20. Intelligent Re-Use of Nursing Routine Data: Opportunities and Challenges.

    Science.gov (United States)

    Hackl, Werner O

    2016-01-01

    Secondary use of structured nursing routine data receives an increasing attention in healthcare and is supposed to bear huge potential for different purposes. However, building and analyzing such integrated nursing routine data repositories are nontrivial, challenging tasks. The workshop gives an insight in the state of the art of secondary data analysis in nursing and addresses possible opportunities as well as the main challenges when re-using nursing data for secondary analyses. The target audience of the workshop comprises all stakeholders who are interested in the intelligent re-use of nursing data (e.g. decision-makers, public health officials, nursing managers, nursing informatics/IT staff, scientists, data analysts as well as industry representatives).

  1. Blockchains for Business Process Management - Challenges and Opportunities

    DEFF Research Database (Denmark)

    Mendling, Jan; Weber, Ingo; Van Der Aalst, Wil

    2018-01-01

    Blockchain technology offers a sizable promise to rethink the way inter-organizational business processes are managed because of its potential to realize execution without a central party serving as a single point of trust (and failure). To stimulate research on this promise and the limits thereof......, in this paper we outline the challenges and opportunities of blockchain for Business Process Management (BPM). We first reflect how blockchains could be used in the context of the established BPM lifecycle and second how they might become relevant beyond. We conclude our discourse with a summary of seven...... research directions for investigating the application of blockchain technology in the context of BPM...

  2. Autism genetics: opportunities and challenges for clinical translation.

    Science.gov (United States)

    Vorstman, Jacob A S; Parr, Jeremy R; Moreno-De-Luca, Daniel; Anney, Richard J L; Nurnberger, John I; Hallmayer, Joachim F

    2017-06-01

    Genetic studies have revealed the involvement of hundreds of gene variants in autism. Their risk effects are highly variable, and they are frequently related to other conditions besides autism. However, many different variants converge on common biological pathways. These findings indicate that aetiological heterogeneity, variable penetrance and genetic pleiotropy are pervasive characteristics of autism genetics. Although this advancing insight should improve clinical care, at present there is a substantial discrepancy between research knowledge and its clinical application. In this Review, we discuss the current challenges and opportunities for the translation of autism genetics knowledge into clinical practice.

  3. Tooth regeneration: challenges and opportunities for biomedical material research.

    Science.gov (United States)

    Du, Chang; Moradian-Oldak, Janet

    2006-03-01

    Tooth regeneration presents many challenges to researchers in the fields of biology, medicine and material science. This review considers the opportunities for biomedical material research to contribute to this multidisciplinary endeavor. We present short summaries and an overview on the collective knowledge of tooth developmental biology, advances in stem-cell research, and progress in the understanding of the tooth biomineralization principles as they provide the foundation for developing strategies for reparative and regenerative medicine. We emphasize that various biomaterials developed via biomimetic strategies have great potential for tooth tissue engineering and regeneration applications. The current practices in tooth tissue engineering approaches and applications of biomimetic carriers or scaffolds are also discussed.

  4. Political communication research: New media, new challenges, and new opportunities

    OpenAIRE

    Rasmus Kleis Nielsen

    2014-01-01

    The rise of new media and the broader set of social changes they are part of present political communication research with new challenges and new opportunities at a time when many think the field is at an intellectual impasse (e.g., Bennett & Iyengar, 2008). In this article, I argue that parts of the field’s problems are rooted in the way in which political communication research has developed since the 1960s. In this period, the field has moved from being interdisciplinary and mixed-meth...

  5. Challenges and opportunities in mapping land use intensity globally

    DEFF Research Database (Denmark)

    Kuemmerle, Tobias; Erb, Karlheinz; Meyfroidt, Patrick

    2013-01-01

    Future increases in land-based production will need to focus more on sustainably intensifying existing production systems. Unfortunately, our understanding of the global patterns of land use intensity is weak, partly because land use intensity is a complex, multidimensional term, and partly becau...... challenges and opportunities for mapping land use intensity for cropland, grazing, and forestry systems, and identify key issues for future research.......Future increases in land-based production will need to focus more on sustainably intensifying existing production systems. Unfortunately, our understanding of the global patterns of land use intensity is weak, partly because land use intensity is a complex, multidimensional term, and partly because...

  6. Leveraging structure for enzyme function prediction: methods, opportunities, and challenges.

    Science.gov (United States)

    Jacobson, Matthew P; Kalyanaraman, Chakrapani; Zhao, Suwen; Tian, Boxue

    2014-08-01

    The rapid growth of the number of protein sequences that can be inferred from sequenced genomes presents challenges for function assignment, because only a small fraction (currently predict functions of uncharacterized proteins. Recently, there has been significant progress in using protein structures as an additional source of information to infer aspects of enzyme function, which is the focus of this review. Successful application of these approaches has led to the identification of novel metabolites, enzyme activities, and biochemical pathways. We discuss opportunities to elucidate systematically protein domains of unknown function, orphan enzyme activities, dead-end metabolites, and pathways in secondary metabolism. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. Electronic publishing: opportunities and challenges for clinical linguistics and phonetics.

    Science.gov (United States)

    Powell, Thomas W; Müller, Nicole; Ball, Martin J

    2003-01-01

    This paper discusses the contributions of informatics technology to the field of clinical linguistics and phonetics. The electronic publication of research reports and books has facilitated both the dissemination and the retrieval of scientific information. Electronic archives of speech and language corpora, too, stimulate research efforts. Although technology provides many opportunities, there remain significant challenges. Establishment and maintenance of scientific archives is largely dependent upon volunteer efforts, and there are few standards to ensure long-term access. Coordinated efforts and peer review are necessary to ensure utility and quality.

  8. Enterprise Implementation of Digital Pathology: Feasibility, Challenges, and Opportunities.

    Science.gov (United States)

    Hartman, D J; Pantanowitz, L; McHugh, J S; Piccoli, A L; OLeary, M J; Lauro, G R

    2017-10-01

    Digital pathology is becoming technically possible to implement for routine pathology work. At our institution, we have been using digital pathology for second opinion intraoperative consultations for over 10 years. Herein, we describe our experience in converting to a digital pathology platform for primary pathology diagnosis. We implemented an incremental rollout for digital pathology on subspecialty benches, beginning with cases that contained small amounts of tissue (biopsy specimens). We successfully scanned over 40,000 slides through our digital pathology system. Several lessons (both challenges and opportunities) were learned through this implementation. A successful conversion to digital pathology requires pre-imaging adjustments, integrated software and post-imaging evaluations.

  9. Improvement of Salinity Stress Tolerance in Rice: Challenges and Opportunities

    Directory of Open Access Journals (Sweden)

    Thi My Linh Hoang

    2016-10-01

    Full Text Available Rice (Oryza sativa L. is an important staple crop that feeds more than one half of the world’s population and is the model system for monocotyledonous plants. However, rice is very sensitive to salinity and is the most salt sensitive cereal crop with a threshold of 3 dSm−1 for most cultivated varieties. Despite many attempts using different strategies to improve salinity tolerance in rice, the achievements so far are quite modest. This review aims to discuss challenges that hinder the improvement of salinity stress tolerance in rice as well as potential opportunities for enhancing salinity stress tolerance in this important crop.

  10. Learner-Adaptive Educational Technology for Simulation in Healthcare: Foundations and Opportunities.

    Science.gov (United States)

    Lineberry, Matthew; Dev, Parvati; Lane, H Chad; Talbot, Thomas B

    2018-01-17

    Despite evidence that learners vary greatly in their learning needs, practical constraints tend to favor "one-size-fits-all" educational approaches, in simulation-based education as elsewhere. Adaptive educational technologies - devices and/or software applications that capture and analyze relevant data about learners to select and present individually tailored learning stimuli - are a promising aid in learners' and educators' efforts to provide learning experiences that meet individual needs. In this article, we summarize and build upon the 2017 Society for Simulation in Healthcare Research Summit panel discussion on adaptive learning. First, we consider the role of adaptivity in learning broadly. We then outline the basic functions that adaptive learning technologies must implement and the unique affordances and challenges of technology-based approaches for those functions, sharing an illustrative example from healthcare simulation. Finally, we consider future directions for accelerating research, development, and deployment of effective adaptive educational technology and techniques in healthcare simulation.

  11. Opportunities and challenges in social pharmacy and pharmacy practice research

    DEFF Research Database (Denmark)

    Almarsdóttir, Anna Birna; Kaae, Susanne; Traulsen, Janine M

    2014-01-01

    Pharmacy practice and social pharmacy are two important research areas within pharmaceutical and health sciences. As the disciplines have undergone and are still undergoing changes, it is useful to reflect on the current state of their research as the basis for discussing further development...... ever before. In this article, the challenges and opportunities in current research are reviewed, and suggestions provided on how to further research in these areas. A systematic content analysis is important to benchmark trends in the types of studies conducted, and to map the collaboration and funding....... The two areas are currently beset by a lack of consensus and charged all too often with evaluating narrowly focused pharmacy services. With the added challenge of diminished funding for research and the pressures to publish results, these fields have to accommodate a much broader research framework than...

  12. Opportunities and challenges of using technology to address health disparities.

    Science.gov (United States)

    Rivers, Brian M; Bernhardt, Jay M; Fleisher, Linda; Green, Bernard Lee

    2014-03-01

    During a panel presentation at the American Association for Cancer Research Cancer Health Disparities Conference titled 'Opportunities and challenges of using technology to address health disparities', the latest scientific advances in the application and utilization of mobile technology and/or mobile-health (mHealth) interventions to address cancer health disparities were discussed. The session included: an examination of overall population trends in the uptake of technology and the potential of addressing health disparities through such media; an exploration of the conceptual issues and challenges in the construction of mHealth interventions to address disparate and underserved populations; and a presentation of pilot study findings on the acceptability and feasibility of using mHealth interventions to address prostate cancer disparities among African-American men.

  13. Anaerobic digestion of lignocellulosic biomass: challenges and opportunities.

    Science.gov (United States)

    Sawatdeenarunat, Chayanon; Surendra, K C; Takara, Devin; Oechsner, Hans; Khanal, Samir Kumar

    2015-02-01

    Anaerobic digestion (AD) of lignocellulosic biomass provides an excellent opportunity to convert abundant bioresources into renewable energy. Rumen microorganisms, in contrast to conventional microorganisms, are an effective inoculum for digesting lignocellulosic biomass due to their intrinsic ability to degrade substrate rich in cellulosic fiber. However, there are still several challenges that must be overcome for the efficient digestion of lignocellulosic biomass. Anaerobic biorefinery is an emerging concept that not only generates bioenergy, but also high-value biochemical/products from the same feedstock. This review paper highlights the current status of lignocellulosic biomass digestion and discusses its challenges. The paper also discusses the future research needs of lignocellulosic biomass digestion. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Family caregiver recruitment via social media: challenges, opportunities and lessons.

    Science.gov (United States)

    Hansen, Dana; Sheehan, Denice K; Stephenson, Pam

    2017-02-02

    Illness blogs are a way seriously ill people communicate publicly about their illness journey. As communication about serious illness increases on social media, it is important to evaluate how this affects the family caregiver. However, identifying and accessing family caregivers remains challenging, especially via social media. The aim of this article is to report the opportunities, challenges and lessons learned from using social media to recruit family caregivers. Recruitment methods included posting study invitations on illness blogs, advertising through Facebook and placing study fliers in the community. Using social media to recruit was inexpensive and provided a wide geographical reach. One important finding was discovering the importance of using language in the recruitment materials that family caregivers could identify with to help deem themselves as eligible to participate in the study.

  15. Challenges and opportunities for meningococcal vaccination in the developing world.

    Science.gov (United States)

    Shaker, Rouba; Fayad, Danielle; Dbaibo, Ghassan

    2018-02-02

    Meningococcal disease continues to be a life threatening infection with high morbidity and mortality even in appropriately treated patients. Meningococcal vaccination plays a major role in the control of the disease; however, implementing vaccination remains problematic in the developing world. The objective of this review is to identify the challenges facing the use of meningococcal vaccines in the developing world in order to discuss the opportunities and available solutions to improve immunization in these countries. Inadequate epidemiologic information necessary to implement vaccination and financial challenges predominate. Multiple measures are needed to achieve the successful implementation of meningococcal conjugate vaccination programs that protect against circulating serogroups in developing countries including enhanced surveillance systems, financial support and aid through grants, product development partnerships that are the end result of effective collaboration and communication between different interdependent stakeholders to develop affordable vaccines, and demonstration of the cost-effectiveness of new meningococcal vaccines.

  16. Big data and biomedical informatics: a challenging opportunity.

    Science.gov (United States)

    Bellazzi, R

    2014-05-22

    Big data are receiving an increasing attention in biomedicine and healthcare. It is therefore important to understand the reason why big data are assuming a crucial role for the biomedical informatics community. The capability of handling big data is becoming an enabler to carry out unprecedented research studies and to implement new models of healthcare delivery. Therefore, it is first necessary to deeply understand the four elements that constitute big data, namely Volume, Variety, Velocity, and Veracity, and their meaning in practice. Then, it is mandatory to understand where big data are present, and where they can be beneficially collected. There are research fields, such as translational bioinformatics, which need to rely on big data technologies to withstand the shock wave of data that is generated every day. Other areas, ranging from epidemiology to clinical care, can benefit from the exploitation of the large amounts of data that are nowadays available, from personal monitoring to primary care. However, building big data-enabled systems carries on relevant implications in terms of reproducibility of research studies and management of privacy and data access; proper actions should be taken to deal with these issues. An interesting consequence of the big data scenario is the availability of new software, methods, and tools, such as map-reduce, cloud computing, and concept drift machine learning algorithms, which will not only contribute to big data research, but may be beneficial in many biomedical informatics applications. The way forward with the big data opportunity will require properly applied engineering principles to design studies and applications, to avoid preconceptions or over-enthusiasms, to fully exploit the available technologies, and to improve data processing and data management regulations.

  17. Big Data and Biomedical Informatics: A Challenging Opportunity

    Science.gov (United States)

    2014-01-01

    Summary Big data are receiving an increasing attention in biomedicine and healthcare. It is therefore important to understand the reason why big data are assuming a crucial role for the biomedical informatics community. The capability of handling big data is becoming an enabler to carry out unprecedented research studies and to implement new models of healthcare delivery. Therefore, it is first necessary to deeply understand the four elements that constitute big data, namely Volume, Variety, Velocity, and Veracity, and their meaning in practice. Then, it is mandatory to understand where big data are present, and where they can be beneficially collected. There are research fields, such as translational bioinformatics, which need to rely on big data technologies to withstand the shock wave of data that is generated every day. Other areas, ranging from epidemiology to clinical care, can benefit from the exploitation of the large amounts of data that are nowadays available, from personal monitoring to primary care. However, building big data-enabled systems carries on relevant implications in terms of reproducibility of research studies and management of privacy and data access; proper actions should be taken to deal with these issues. An interesting consequence of the big data scenario is the availability of new software, methods, and tools, such as map-reduce, cloud computing, and concept drift machine learning algorithms, which will not only contribute to big data research, but may be beneficial in many biomedical informatics applications. The way forward with the big data opportunity will require properly applied engineering principles to design studies and applications, to avoid preconceptions or over-enthusiasms, to fully exploit the available technologies, and to improve data processing and data management regulations. PMID:24853034

  18. Telerehabilitation Clinical and Vocational Applications for Assistive Technology: Research, Opportunities, and Challenges

    Directory of Open Access Journals (Sweden)

    Mark R. Schmeler

    2009-09-01

    Full Text Available Rehabilitation service providers in rural or underserved areas are often challenged in meeting the needs of their complex patients due to limited resources in their geographical area. Recruitment and retention of the rural clinical workforce are beset by the ongoing problems associated with limited continuing education opportunities, professional isolation, and the challenges inherent in coordinating rural community healthcare. People with disabilities who live in rural communities also face challenges accessing healthcare. Traveling long distances to a specialty clinic for necessary expertise may be troublesome due to inadequate or unavailable transportation, disability specific limitations, and financial limitations. Distance and lack of access are just two threats to quality of care that now being addressed by the use of videoconferencing, information exchange, and other telecommunication technologies that facilitate telerehabilitation. This white paper illustrates and summarizes clinical and vocational applications of telerehabilitation. We provide definitions related to the fields of telemedicine, telehealth, and telerehabilitation, and consider the impetus for telerehabilitation. We review the telerehabilitation literature for assistive technology applications; pressure ulcer prevention; virtual reality applications; speech-language pathology applications; seating and wheeled mobility applications; vocational rehabilitation applications; and cost effectiveness. We then discuss external telerehabilitation influencers, such as the positions of professional organizations. Finally, we summarize clinical and policy issues in a limited context appropriate to the scope of this paper. Keywords: Telerehabilitation, Telehealth, Telemedicine, Telepractice

  19. Telerehabilitation clinical and vocational applications for assistive technology: research, opportunities, and challenges.

    Science.gov (United States)

    Schmeler, Mark R; Schein, Richard M; McCue, Michael; Betz, Kendra

    2009-01-01

    Rehabilitation service providers in rural or underserved areas are often challenged in meeting the needs of their complex patients due to limited resources in their geographical area. Recruitment and retention of the rural clinical workforce are beset by the ongoing problems associated with limited continuing education opportunities, professional isolation, and the challenges inherent in coordinating rural community healthcare. People with disabilities who live in rural communities also face challenges accessing healthcare. Traveling long distances to a specialty clinic for necessary expertise may be troublesome due to inadequate or unavailable transportation, disability specific limitations, and financial limitations. Distance and lack of access are just two threats to quality of care that now being addressed by the use of videoconferencing, information exchange, and other telecommunication technologies that facilitate telerehabilitation. This white paper illustrates and summarizes clinical and vocational applications of telerehabilitation. We provide definitions related to the fields of telemedicine, telehealth, and telerehabilitation, and consider the impetus for telerehabilitation. We review the telerehabilitation literature for assistive technology applications; pressure ulcer prevention; virtual reality applications; speech-language pathology applications; seating and wheeled mobility applications; vocational rehabilitation applications; and cost-effectiveness. We then discuss external telerehabilitation influencers, such as the positions of professional organizations. Finally, we summarize clinical and policy issues in a limited context appropriate to the scope of this paper.

  20. Role, Challenges, and Opportunities in Multi-scale Laboratory Experimentation

    Science.gov (United States)

    Illangasekare, Tissa

    2017-04-01

    Fundamental to the distribution of water and effects on its quality are the processes of energy, mass, and momentum transfer in hydrologic systems. I will introduce a class of problems that offers special challenges when these processes occur either across physical interfaces or through transition zones with embedded interfaces. Some of the challenges are a result of hard to define interface topologies, abrupt transition of phase properties, contrasting phase flow and energy dynamics, difficult to characterize simultaneously occurring but different types of transfer processes, and modeling complexities. The data to study these processes cannot always be obtained from controlled field experiments where many factors contribute to the uncertainty of measurements and parameter estimates. The primary thesis of this talk is that laboratory experimentation at multiple test scales will continue to play an important and a useful role in hydrology and will provide new opportunities to improve fundamental process understanding. This knowledge will lead to increased accuracy of predictions and improved upscaling methods. However, performing such experiments pose many challenges such as acquisition of data at different observational scales and close to interfaces, capturing critical features of geologic heterogeneity, mimicking field specific pressure and temperature dependent phase interaction parameters under ambient laboratory conditions, and simulating climate drivers, among others. Through examples in multiphase systems and land/atmospheric interactions, I will show how to address some of these challenges through the design and implementation of theory-driven experiments.

  1. Big data in complex systems challenges and opportunities

    CERN Document Server

    Azar, Ahmad; Snasael, Vaclav; Kacprzyk, Janusz; Abawajy, Jemal

    2015-01-01

    This volume provides challenges and Opportunities with updated, in-depth material on the application of Big data to complex systems in order to find solutions for the challenges and problems facing big data sets applications. Much data today is not natively in structured format; for example, tweets and blogs are weakly structured pieces of text, while images and video are structured for storage and display, but not for semantic content and search. Therefore transforming such content into a structured format for later analysis is a major challenge. Data analysis, organization, retrieval, and modeling are other  foundational challenges treated in this book. The material of this book will be useful for researchers and practitioners in the field of big data as well as advanced undergraduate and graduate  students. Each of the 17 chapters in the book opens with a chapter abstract and key terms list. The chapters are organized along the lines of problem description, related works, and analysis of the results and ...

  2. Opportunities and challenges for public libraries to enhance community resilience.

    Science.gov (United States)

    Veil, Shari R; Bishop, Bradley Wade

    2014-04-01

    This study bridges a gap between public library and emergency management policy versus practice by examining the role of public libraries in the community resource network for disaster recovery. Specifically, this study identifies the opportunities and challenges for public libraries to fulfill their role as a FEMA-designated essential community organization and enhance community resilience. The results indicate there are several opportunities for libraries to enhance community resilience by offering technology resources and assistance; providing office, meeting, and community living room space; serving as the last redundant communication channel and a repository for community information and disaster narratives; and adapting or expanding services already offered to meet the changing needs of the community. However, libraries also face challenges in enhancing community resilience, including the temptation to overcommit library capacity and staff capability beyond the library mission and a lack of long-term disaster plans and collaboration with emergency managers and government officials. Implications for library and emergency management practice and crisis research are discussed. © 2013 Society for Risk Analysis.

  3. Processing Challenges and Opportunities of Camel Dairy Products

    Science.gov (United States)

    Seifu, Eyassu; Ipsen, Richard; Kurtu, Mohamed Y.; Hansen, Egon Bech

    2017-01-01

    A review on the challenges and opportunities of processing camel milk into dairy products is provided with an objective of exploring the challenges of processing and assessing the opportunities for developing functional products from camel milk. The gross composition of camel milk is similar to bovine milk. Nonetheless, the relative composition, distribution, and the molecular structure of the milk components are reported to be different. Consequently, manufacturing of camel dairy products such as cheese, yoghurt, or butter using the same technology as for dairy products from bovine milk can result in processing difficulties and products of inferior quality. However, scientific evidence points to the possibility of transforming camel milk into products by optimization of the processing parameters. Additionally, camel milk has traditionally been used for its medicinal values and recent scientific studies confirm that it is a rich source of bioactive, antimicrobial, and antioxidant substances. The current literature concerning product design and functional potential of camel milk is fragmented in terms of time, place, and depth of the research. Therefore, it is essential to understand the fundamental features of camel milk and initiate detailed multidisciplinary research to fully explore and utilize its functional and technological properties. PMID:29109953

  4. Urban Big Data and Sustainable Development Goals: Challenges and Opportunities

    Directory of Open Access Journals (Sweden)

    Ali Kharrazi

    2016-12-01

    Full Text Available Cities are perhaps one of the most challenging and yet enabling arenas for sustainable development goals. The Sustainable Development Goals (SDGs emphasize the need to monitor each goal through objective targets and indicators based on common denominators in the ability of countries to collect and maintain relevant standardized data. While this approach is aimed at harmonizing the SDGs at the national level, it presents unique challenges and opportunities for the development of innovative urban-level metrics through big data innovations. In this article, we make the case for advancing more innovative targets and indicators relevant to the SDGs through the emergence of urban big data. We believe that urban policy-makers are faced with unique opportunities to develop, experiment, and advance big data practices relevant to sustainable development. This can be achieved by situating the application of big data innovations through developing mayoral institutions for the governance of urban big data, advancing the culture and common skill sets for applying urban big data, and investing in specialized research and education programs.

  5. Big Data in Designing Clinical Trials: Opportunities and Challenges

    Directory of Open Access Journals (Sweden)

    Charles S. Mayo

    2017-08-01

    Full Text Available Emergence of big data analytics resource systems (BDARSs as a part of routine practice in Radiation Oncology is on the horizon. Gradually, individual researchers, vendors, and professional societies are leading initiatives to create and demonstrate use of automated systems. What are the implications for design of clinical trials, as these systems emerge? Gold standard, randomized controlled trials (RCTs have high internal validity for the patients and settings fitting constraints of the trial, but also have limitations including: reproducibility, generalizability to routine practice, infrequent external validation, selection bias, characterization of confounding factors, ethics, and use for rare events. BDARS present opportunities to augment and extend RCTs. Preliminary modeling using single- and muti-institutional BDARS may lead to better design and less cost. Standardizations in data elements, clinical processes, and nomenclatures used to decrease variability and increase veracity needed for automation and multi-institutional data pooling in BDARS also support ability to add clinical validation phases to clinical trial design and increase participation. However, volume and variety in BDARS present other technical, policy, and conceptual challenges including applicable statistical concepts, cloud-based technologies. In this summary, we will examine both the opportunities and the challenges for use of big data in design of clinical trials.

  6. Mapping opportunities and challenges for rewilding in Europe.

    Science.gov (United States)

    Ceaușu, Silvia; Hofmann, Max; Navarro, Laetitia M; Carver, Steve; Verburg, Peter H; Pereira, Henrique M

    2015-08-01

    Farmland abandonment takes place across the world due to socio-economic and ecological drivers. In Europe agricultural and environmental policies aim to prevent abandonment and halt ecological succession. Ecological rewilding has been recently proposed as an alternative strategy. We developed a framework to assess opportunities for rewilding across different dimensions of wilderness in Europe. We mapped artificial light, human accessibility based on transport infrastructure, proportion of harvested primary productivity (i.e., ecosystem productivity appropriated by humans through agriculture or forestry), and deviation from potential natural vegetation in areas projected to be abandoned by 2040. At the continental level, the levels of artificial light were low and the deviation from potential natural vegetation was high in areas of abandonment. The relative importance of wilderness metrics differed regionally and was strongly connected to local environmental and socio-economic contexts. Large areas of projected abandonment were often located in or around Natura 2000 sites. Based on these results, we argue that management should be tailored to restore the aspects of wilderness that are lacking in each region. There are many remaining challenges regarding biodiversity in Europe, but megafauna species are already recovering. To further potentiate large-scale rewilding, Natura 2000 management would need to incorporate rewilding approaches. Our framework can be applied to assessing rewilding opportunities and challenges in other world regions, and our results could guide redirection of subsidies to manage social-ecological systems. © 2015 The Authors. Conservation Biology published by wiley Periodicals, Inc. on behalf of the Society for Conservation Biology.

  7. Oceanography from the SWOT Mission: Opportunities and Challenges

    Science.gov (United States)

    Fu, L. L.; Morrow, R.

    2016-12-01

    The Surface Water and Ocean Topography (SWOT) is a joint mission of NASA and the French Space Agency CNES, with contributions from Canada and UK. The primary instrument of SWOT is a Ka-band radar interferometer for measuring the elevation of water surface over land and ocean. The oceanographic objectives of the mission are to observe sea surface height (SSH) at scales approaching 15 km, depending on the sea state. SWOT will make SSH measurement over a swath of 120 km with a nadir gap of 20 km in a 21-day repeat orbit to map the entire ocean with minimal gaps. A conventional radar altimeter will provide measurement along the nadir gap. There will be a 90-day calibration/validation phase with a 1-day repeat orbit to assess the mission performance and study the high-frequency oceanographic processes. The coverage and resolution of the mission will represent significant improvement over conventional altimetry. This is an exploratory mission with applications in oceanography and hydrology. The increased spatial resolution offers an unprecedented opportunity to study finer-scale 2D ocean surface height processes and to address important questions about the ocean circulation, and its interaction with ocean tides. However, the limited temporal sampling poses challenges to map the evolution of the ocean variability that changes rapidly at small scales. The measurement technique and the development of the mission will be presented with an emphasis on its science program with an outlook on the opportunities and challenges.

  8. Epigenetic research in multiple sclerosis: progress, challenges, and opportunities.

    Science.gov (United States)

    Zheleznyakova, Galina Y; Piket, Eliane; Marabita, Francesco; Pahlevan Kakhki, Majid; Ewing, Ewoud; Ruhrmann, Sabrina; Needhamsen, Maria; Jagodic, Maja; Kular, Lara

    2017-09-01

    Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system. MS likely results from a complex interplay between predisposing causal gene variants (the strongest influence coming from HLA class II locus) and environmental risk factors such as smoking, infectious mononucleosis, and lack of sun exposure/vitamin D. However, little is known about the mechanisms underlying MS development and progression. Moreover, the clinical heterogeneity and variable response to treatment represent additional challenges to a comprehensive understanding and efficient treatment of disease. Epigenetic processes, such as DNA methylation and histone posttranslational modifications, integrate influences from the genes and the environment to regulate gene expression accordingly. Studying epigenetic modifications, which are stable and reversible, may provide an alternative approach to better understand and manage disease. We here aim to review findings from epigenetic studies in MS and further discuss the challenges and clinical opportunities arising from epigenetic research, many of which apply to other diseases with similar complex etiology. A growing body of evidence supports a role of epigenetic processes in the mechanisms underlying immune pathogenesis and nervous system dysfunction in MS. However, disparities between studies shed light on the need to consider possible confounders and methodological limitations for a better interpretation of the data. Nevertheless, translational use of epigenetics might offer new opportunities in epigenetic-based diagnostics and therapeutic tools for a personalized care of MS patients. Copyright © 2017 the American Physiological Society.

  9. Processing Challenges and Opportunities of Camel Dairy Products

    Directory of Open Access Journals (Sweden)

    Tesfemariam Berhe

    2017-01-01

    Full Text Available A review on the challenges and opportunities of processing camel milk into dairy products is provided with an objective of exploring the challenges of processing and assessing the opportunities for developing functional products from camel milk. The gross composition of camel milk is similar to bovine milk. Nonetheless, the relative composition, distribution, and the molecular structure of the milk components are reported to be different. Consequently, manufacturing of camel dairy products such as cheese, yoghurt, or butter using the same technology as for dairy products from bovine milk can result in processing difficulties and products of inferior quality. However, scientific evidence points to the possibility of transforming camel milk into products by optimization of the processing parameters. Additionally, camel milk has traditionally been used for its medicinal values and recent scientific studies confirm that it is a rich source of bioactive, antimicrobial, and antioxidant substances. The current literature concerning product design and functional potential of camel milk is fragmented in terms of time, place, and depth of the research. Therefore, it is essential to understand the fundamental features of camel milk and initiate detailed multidisciplinary research to fully explore and utilize its functional and technological properties.

  10. Iterative near-term ecological forecasting: Needs, opportunities, and challenges

    Science.gov (United States)

    Dietze, Michael C.; Fox, Andrew; Beck-Johnson, Lindsay; Betancourt, Julio L.; Hooten, Mevin B.; Jarnevich, Catherine S.; Keitt, Timothy H.; Kenney, Melissa A.; Laney, Christine M.; Larsen, Laurel G.; Loescher, Henry W.; Lunch, Claire K.; Pijanowski, Bryan; Randerson, James T.; Read, Emily; Tredennick, Andrew T.; Vargas, Rodrigo; Weathers, Kathleen C.; White, Ethan P.

    2018-01-01

    Two foundational questions about sustainability are “How are ecosystems and the services they provide going to change in the future?” and “How do human decisions affect these trajectories?” Answering these questions requires an ability to forecast ecological processes. Unfortunately, most ecological forecasts focus on centennial-scale climate responses, therefore neither meeting the needs of near-term (daily to decadal) environmental decision-making nor allowing comparison of specific, quantitative predictions to new observational data, one of the strongest tests of scientific theory. Near-term forecasts provide the opportunity to iteratively cycle between performing analyses and updating predictions in light of new evidence. This iterative process of gaining feedback, building experience, and correcting models and methods is critical for improving forecasts. Iterative, near-term forecasting will accelerate ecological research, make it more relevant to society, and inform sustainable decision-making under high uncertainty and adaptive management. Here, we identify the immediate scientific and societal needs, opportunities, and challenges for iterative near-term ecological forecasting. Over the past decade, data volume, variety, and accessibility have greatly increased, but challenges remain in interoperability, latency, and uncertainty quantification. Similarly, ecologists have made considerable advances in applying computational, informatic, and statistical methods, but opportunities exist for improving forecast-specific theory, methods, and cyberinfrastructure. Effective forecasting will also require changes in scientific training, culture, and institutions. The need to start forecasting is now; the time for making ecology more predictive is here, and learning by doing is the fastest route to drive the science forward.

  11. Emergence of 3D Printed Dosage Forms: Opportunities and Challenges.

    Science.gov (United States)

    Alhnan, Mohamed A; Okwuosa, Tochukwu C; Sadia, Muzna; Wan, Ka-Wai; Ahmed, Waqar; Arafat, Basel

    2016-08-01

    The recent introduction of the first FDA approved 3D-printed drug has fuelled interest in 3D printing technology, which is set to revolutionize healthcare. Since its initial use, this rapid prototyping (RP) technology has evolved to such an extent that it is currently being used in a wide range of applications including in tissue engineering, dentistry, construction, automotive and aerospace. However, in the pharmaceutical industry this technology is still in its infancy and its potential yet to be fully explored. This paper presents various 3D printing technologies such as stereolithographic, powder based, selective laser sintering, fused deposition modelling and semi-solid extrusion 3D printing. It also provides a comprehensive review of previous attempts at using 3D printing technologies on the manufacturing dosage forms with a particular focus on oral tablets. Their advantages particularly with adaptability in the pharmaceutical field have been highlighted, which enables the preparation of dosage forms with complex designs and geometries, multiple actives and tailored release profiles. An insight into the technical challenges facing the different 3D printing technologies such as the formulation and processing parameters is provided. Light is also shed on the different regulatory challenges that need to be overcome for 3D printing to fulfil its real potential in the pharmaceutical industry.

  12. Climate Change Adaptation Challenges and EO Business Opportunities

    Science.gov (United States)

    Lopez-Baeza, Ernesto; Mathieu, Pierre-Philippe; Bansal, Rahul; Del Rey, Maria; Mohamed, Ebrahim; Ruiz, Paz; Signes, Marcos

    Climate change is one of the defining challenges of the 21st century, but is no longer a matter of just scientific concern. It encompasses economics, sociology, global politics as well as national and local politics, law, health and environmental security, etc. The challenge of facing the impacts of climate change is often framed in terms of two potential paths that civilization might take: mitigation and adaptation. On the one hand, mitigation involves reducing the magnitude of climate change itself and is composed of emissions reductions and geoengineering. On the other hand and by contrast, adaptation involves efforts to limit our vulnerability to climate change impacts through various measures. It refers to our ability to adjust ourselves to climate change -including climate variability and extremes, to moderate potential damage, to take advantage of opportunities, or to cope with the consequences. Therefore, we are now faced with a double challenge: next to deep cuts in greenhouse gas emissions, we also need to adapt to the changing climate conditions. The use of satellites to monitor processes and trends at the global scale is essential in the context of climate change. Earth Observation has the potential to improve our predictive vision and to advance climate models. Space sciences and technologies constitute a significant issue in Education and Public Awareness of Science. Space missions face the probably largest scientific and industrial challenges of humanity. It is thus a fact that space drives innovation in the major breakthrough and cutting edge technological advances of mankind (techniques, processes, new products, … as well as in markets and business models). Technology and innovation is the basis of all space activities. Space agencies offer an entire range of space-related activities - from space science and environmental monitoring to industrial competitiveness and end-user services. More specifically, Earth Observation satellites have a unique

  13. Propulsion challenges and opportunities for high-speed transport aircraft

    Science.gov (United States)

    Strack, William C.

    1987-01-01

    For several years there was a growing interest in the subject of efficient sustained supersonic cruise technology applied to a high-speed transport aircraft. The major challenges confronting the propulsion community for supersonic transport (SST) applications are identified. Both past progress and future opportunities are discussed in relation to perceived technology shortfalls for an economically successful SST that satisfies environmental constraints. A very large improvement in propulsion system efficiency is needed both at supersonic and subsonic cruise conditions. Toward that end, several advanced engine concepts are being considered that, together with advanced discipline and component technologies, promise at least 40 percent better efficiency that the Concorde engine. The quest for higher productivity through higher speed is also thwarted by the lack of a conventional, low-priced fuel that is thermally stable at the higher temperatures associated with faster flight. Airport noise remains a tough challenge because previously researched concepts fall short of achieving FAR 36 Stage 3 noise levels. Innovative solutions may be necessary to reach acceptably low noise. While the technical challenges are indeed formidable, it is reasonable to assume that the current shortfalls in fuel economy and noise can be overcome through an aggressive propulsion research program.

  14. Remote sensing of ecosystem health: opportunities, challenges, and future perspectives.

    Science.gov (United States)

    Li, Zhaoqin; Xu, Dandan; Guo, Xulin

    2014-11-07

    Maintaining a healthy ecosystem is essential for maximizing sustainable ecological services of the best quality to human beings. Ecological and conservation research has provided a strong scientific background on identifying ecological health indicators and correspondingly making effective conservation plans. At the same time, ecologists have asserted a strong need for spatially explicit and temporally effective ecosystem health assessments based on remote sensing data. Currently, remote sensing of ecosystem health is only based on one ecosystem attribute: vigor, organization, or resilience. However, an effective ecosystem health assessment should be a comprehensive and dynamic measurement of the three attributes. This paper reviews opportunities of remote sensing, including optical, radar, and LiDAR, for directly estimating indicators of the three ecosystem attributes, discusses the main challenges to develop a remote sensing-based spatially-explicit comprehensive ecosystem health system, and provides some future perspectives. The main challenges to develop a remote sensing-based spatially-explicit comprehensive ecosystem health system are: (1) scale issue; (2) transportability issue; (3) data availability; and (4) uncertainties in health indicators estimated from remote sensing data. However, the Radarsat-2 constellation, upcoming new optical sensors on Worldview-3 and Sentinel-2 satellites, and improved technologies for the acquisition and processing of hyperspectral, multi-angle optical, radar, and LiDAR data and multi-sensoral data fusion may partly address the current challenges.

  15. Opportunities and Challenges in Deep Mining: A Brief Review

    Directory of Open Access Journals (Sweden)

    Pathegama G. Ranjith

    2017-08-01

    Full Text Available Mineral consumption is increasing rapidly as more consumers enter the market for minerals and as the global standard of living increases. As a result, underground mining continues to progress to deeper levels in order to tackle the mineral supply crisis in the 21st century. However, deep mining occurs in a very technical and challenging environment, in which significant innovative solutions and best practice are required and additional safety standards must be implemented in order to overcome the challenges and reap huge economic gains. These challenges include the catastrophic events that are often met in deep mining engineering: rockbursts, gas outbursts, high in situ and redistributed stresses, large deformation, squeezing and creeping rocks, and high temperature. This review paper presents the current global status of deep mining and highlights some of the newest technological achievements and opportunities associated with rock mechanics and geotechnical engineering in deep mining. Of the various technical achievements, unmanned working-faces and unmanned mines based on fully automated mining and mineral extraction processes have become important fields in the 21st century.

  16. Remote Sensing of Ecosystem Health: Opportunities, Challenges, and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Zhaoqin Li

    2014-11-01

    Full Text Available Maintaining a healthy ecosystem is essential for maximizing sustainable ecological services of the best quality to human beings. Ecological and conservation research has provided a strong scientific background on identifying ecological health indicators and correspondingly making effective conservation plans. At the same time, ecologists have asserted a strong need for spatially explicit and temporally effective ecosystem health assessments based on remote sensing data. Currently, remote sensing of ecosystem health is only based on one ecosystem attribute: vigor, organization, or resilience. However, an effective ecosystem health assessment should be a comprehensive and dynamic measurement of the three attributes. This paper reviews opportunities of remote sensing, including optical, radar, and LiDAR, for directly estimating indicators of the three ecosystem attributes, discusses the main challenges to develop a remote sensing-based spatially-explicit comprehensive ecosystem health system, and provides some future perspectives. The main challenges to develop a remote sensing-based spatially-explicit comprehensive ecosystem health system are: (1 scale issue; (2 transportability issue; (3 data availability; and (4 uncertainties in health indicators estimated from remote sensing data. However, the Radarsat-2 constellation, upcoming new optical sensors on Worldview-3 and Sentinel-2 satellites, and improved technologies for the acquisition and processing of hyperspectral, multi-angle optical, radar, and LiDAR data and multi-sensoral data fusion may partly address the current challenges.

  17. Patient level costing in Ireland: process, challenges and opportunities.

    Science.gov (United States)

    Murphy, A; McElroy, B

    2015-03-01

    In 2013, the Department of Health released their policy paper on hospital financing entitled Money Follows the Patient. A fundamental building block for the proposed financing model is patient level costing. This paper outlines the patient level costing process, identifies the opportunities and considers the challenges associated with the process in the Irish hospital setting. Methods involved a review of the existing literature which was complemented with an interview with health service staff. There are considerable challenges associated with implementing patient level costing including deficits in information and communication technologies and financial expertise as well as timeliness of coding. In addition, greater clinical input into the costing process is needed compared to traditional costing processes. However, there are long-term benefits associated with patient level costing; these include empowerment of clinical staff, improved transparency and price setting and greater fairness, especially in the treatment of outliers. These can help to achieve the Government's Health Strategy. The benefits of patient level costing need to be promoted and a commitment to investment in overcoming the challenges is required.

  18. Patient Engagement in Kidney Research: Opportunities and Challenges Ahead.

    Science.gov (United States)

    Molnar, Amber O; Barua, Moumita; Konvalinka, Ana; Schick-Makaroff, Kara

    2017-01-01

    Patient engagement in research is increasingly recognized as an important component of the research process and may facilitate translation of research findings. To heighten awareness on this important topic, this review presents opportunities and challenges of patient engagement in research, drawing on specific examples from 4 areas of Canadian kidney research conducted by New Investigators in the Kidney Research Scientist Core Education and National Training (KRESCENT) Program. Research expertise, published reports, peer-reviewed articles, and research funding body websites. In this review, the definition, purpose, and potential benefits of patient engagement in research are discussed. Approaches toward patient engagement that may help with translation and uptake of research findings into clinical practice are highlighted. Opportunities and challenges of patient engagement are presented in both basic science and clinical research with the following examples of kidney research: (1) precision care in focal and segmental glomerulosclerosis, (2) systems biology approaches to improve management of chronic kidney disease and enhance kidney graft survival, (3) reducing the incidence of suboptimal dialysis initiation, and (4) use of patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) in kidney practice. Clinical research affords more obvious opportunities for patient engagement. The most obvious step at which to engage patients is in the setting of research priorities. Engagement at all stages of the research cycle may prove to be more challenging, and requires a detailed plan, along with funds and infrastructure to ensure that it is not merely tokenistic. Basic science research is several steps removed from the clinical application and involves complex scientific concepts, which makes patient engagement inherently more difficult. This is a narrative review of the literature that has been partly influenced by the perspectives and

  19. Social media as marketing tool for SMEs: opportunities and challenges

    Directory of Open Access Journals (Sweden)

    Blerta Rugova

    2016-11-01

    Full Text Available Social media is a phenomenon that has transformed the interaction and communication of individuals throughout the world. Especially, social networking websites are very popular and have become daily practice in a lot of people’s lives. These sites have made significant impact on the individual’s life. However, social media is not only a communication tool for amusement, but it is also an important part of marketing strategies in business life. There is a constant rise in social networking and therefore impact of social networks is becoming stronger every day, into each kind of business. Social media are often used as a source of information and spread of knowledge changing people’s views and opinions. They belong among very important business marketing tactics and help to create new business opportunities, develop a stronger market position or modify consumer’s behaviour. Therefore, in developed countries, social media are gaining popularity and are increasingly used in regular operations of many companies, including start-ups, small, medium-sized, and large organizations. But it seems that in emerging economies such as Kosovo, Albania and other neighbour countries, marketing over social media is not taken that seriously, especially by SMEs. There are some companies who have shown interest and have created their presence, yet there is no serious focus in this innovative marketing tool. The study deals with the issue of social media and its influence on SMEs. It classifies social media and explores the possibilities and challenges of social networks in business. The authors describe features and the evolution of social media, including major social networking sites that came into existence during the 21st century. The purpose of the paper is to review the academic literature on the opportunities and challenges of using social media from SMEs, as well as identifying factors that drive social media marketing adoption and usage in SMEs. This

  20. Providing mental healthcare to immigrants: current challenges and new strategies.

    Science.gov (United States)

    Giacco, Domenico; Matanov, Aleksandra; Priebe, Stefan

    2014-07-01

    The article reviews recent evidence on improving access to mental healthcare for immigrants and best practice of care provision. Language barriers, different beliefs and explanatory models of illness, confidentiality concerns, stigma, reluctance to seek psychological help outside families, and social deprivation may prevent immigrants from accessing mental healthcare. Pathways are influenced by families, primary care practitioners, voluntary organizations, and social services. Interpreting services are often not available, and data documentation on immigrants' use of services is inconsistent. Nonmedical specific services for immigrants can be effective in outreach activities. Cultural training of staff can improve clinicians' attitudes and patients' satisfaction with care. Integrative approaches between primary and mental healthcare, psychoeducational programs, and technological innovations have been developed to improve access to care. Immigrants can face significant barriers in accessing mental healthcare. Strategies to overcome these barriers are as follows: increased coordination and communication between voluntary organizations, social services and mental health services; training of staff on cross-cultural issues; integration of mental healthcare with primary care; psychoeducational initiatives focused on families and broader social groups; and technology-based interventions.

  1. E-LEARNING CHANGE MANAGEMENT: Challenges and opportunities

    Directory of Open Access Journals (Sweden)

    Alaattin PARLAKKILIC

    2013-10-01

    Full Text Available The role of e-learning technologies entirely depends on the acceptance and execution of required-change in the thinking and behaviour of the users of institutions. The research are constantly reporting that many e-learning projects are falling short of their objectives due to many reasons but on the top is the user resistance to change according to the digital requirements of new era. It is argued that the suitable way for change management in e-learning environment is the training and persuading of users with a view to enhance their digital literacy and thus gradually changing the users’ attitude in positive direction. This paper discusses change management in transition to e-learning system considering pedagogical, cost and technical implications. It also discusses challenges and opportunities for integrating these technologies in higher learning institutions with examples from Turkey GATA (Gülhane Askeri Tıp Akademisi-Gülhane Military Medical Academy.

  2. UV/VIS/NIR imaging technologies: challenges and opportunities

    Science.gov (United States)

    Kuroda, Rihito; Sugawa, Shigetoshi

    2015-05-01

    Challenges and opportunities of ultraviolet (UV), visible (VIS) and near-infrared (NIR) light imaging technologies are overviewed in this paper. For light detectors and image sensors for UV/VIS/NIR imaging, it is required that they have high sensitivity for wide spectral light waveband or targeted narrow waveband as well as the high stability of light sensitivity toward UV light based on cost effective technology. Wide spectral response, high sensitivity and high stability advanced Si photodiode (PD) pn junction formation technology based on the flattened Si surface and high transmittance on-chip optical filter formation technology were developed. A linear photodiode array (PDA), wide dynamic range and ultrahigh speed CMOS image sensors employing the developed technology were fabricated and their advanced performances are described in this paper.

  3. Sustainable ground transportation – review of technologies, challenges and opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Agarwal, Ramesh K. [Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO 63130 (United States)

    2013-07-01

    Currently there are nearly 750 million ground vehicles in service worldwide. They are responsible for 50% of petroleum (oil) consumption and 60% of all greenhouse gas (GHG) emissions worldwide. The number of vehicles is forecasted to double by 2050. Therefore the environmental issues such as noise, emissions and fuel burn have become important for energy and environmental sustainability. This paper provides an overview of specific energy and environmental issues related to ground transportation. The technologies related to reduction in energy requirements such as reducing the vehicle mass by using the high strength low weight materials and reducing the viscous drag by active flow control and smoothing the operational profile, and reducing the contact friction by special tire materials are discussed along with the portable energy sources for reducing the GHG emissions such as low carbon fuels (biofuels), Lithium-ion batteries with high energy density and stability, and fuel cells. The technological challenges and opportunities for innovations are discussed.

  4. Mobile Network Data for Public Health: Opportunities and Challenges

    Science.gov (United States)

    Oliver, Nuria; Matic, Aleksandar; Frias-Martinez, Enrique

    2015-01-01

    The ubiquity of mobile phones worldwide is generating an unprecedented amount of human behavioral data both at an individual and aggregated levels. The study of this data as a rich source of information about human behavior emerged almost a decade ago. Since then, it has grown into a fertile area of research named computational social sciences with a wide variety of applications in different fields such as social networks, urban and transport planning, economic development, emergency relief, and, recently, public health. In this paper, we briefly describe the state of the art on using mobile phone data for public health, and present the opportunities and challenges that this kind of data presents for public health. PMID:26301211

  5. Towards precision nephrology: the opportunities and challenges of genomic medicine.

    Science.gov (United States)

    Nestor, Jordan G; Groopman, Emily E; Gharavi, Ali G

    2017-10-17

    The expansion of genomic medicine is furthering our understanding of many human diseases. This is well illustrated in the field of nephrology, through the characterization, discovery, and growing insight into various renal diseases through use of Next Generation Sequencing (NGS) technologies. This review will provide an overview of the diagnostic opportunities of using genetic testing in the clinical setting by describing notable discoveries regarding inherited forms of renal disease that have advanced the field and by highlighting some of the potential benefits of establishing a molecular diagnosis in a clinical practice. In addition, it will discuss some of the challenges associated with the expansion of genetic testing into the clinical setting, including clinical variant interpretation and return of genetic results.

  6. Grand Challenges and Future Opportunities for Metal–Organic Frameworks

    Science.gov (United States)

    2017-01-01

    Metal–organic frameworks (MOFs) allow compositional and structural diversity beyond conventional solid-state materials. Continued interest in the field is justified by potential applications of exceptional breadth, ranging from gas storage and separation, which takes advantage of the inherent pores and their volume, to electronic applications, which requires precise control of electronic structure. In this Outlook we present some of the pertinent challenges that MOFs face in their conventional implementations, as well as opportunities in less traditional areas. Here the aim is to discuss select design concepts and future research goals that emphasize nuances relevant to this class of materials as a whole. Particular emphasis is placed on synthetic aspects, as they influence the potential for MOFs in gas separation, electrical conductivity, and catalytic applications. PMID:28691066

  7. Research fields, challenges and opportunities in European oilseed crops breeding

    Directory of Open Access Journals (Sweden)

    Vincourt Patrick

    2014-11-01

    Full Text Available Due to the geographical specialization in oilseed world production, Europe has a major role to play in winter oilseed rape and sunflower breeding. Mainly based on the most recen t results, this review aims to identify the main research and breeding targets for these two crops, as seen through publications, with an attempt to suggest what are opportunities and challenges in these research fields. Growing a healthy and yielding crop remains the key driver for agronomic production. However sustainability and environmental profiles of the cultivar are now entering the field of play: The sustainability concern invested the field of resistance to diseases. Nitrogen use efficiency became an important target for Brassica napus, and crop resilience toward drought stresses is the way chosen in Helianthus annuus breeding for yield improvement. Significant advances are underway for quality traits, but the uncertainty on nutritional and industrial demand may explain why the product diversification remains low.

  8. Next generation sequencing of microbial transcriptomes: challenges and opportunities.

    Science.gov (United States)

    van Vliet, Arnoud H M

    2010-01-01

    Over the past 15 years, microbial functional genomics has been made possible by the combined power of genome sequencing and microarray technology. However, we are now approaching the technical limits of microarray technology, and microarrays are now being superseded by transcriptomics based on high-throughput (next generation) DNA-sequencing technologies. The term RNA-seq has been coined to represent transcriptomics by next-generation sequencing. Although pioneered on eukaryotic organisms due to the relative ease of working with eukaryotic mRNA, the RNA-seq technology is now being ported to microbial systems. This review will discuss the opportunities of RNA-seq transcriptome sequencing for microorganisms, and also aims to identify challenges and pitfalls of the use of this new technology in microorganisms.

  9. Disposition and safety of inhaled biodegradable nanomedicines: Opportunities and challenges.

    Science.gov (United States)

    Haque, Shadabul; Whittaker, Michael R; McIntosh, Michelle P; Pouton, Colin W; Kaminskas, Lisa M

    2016-08-01

    The inhaled delivery of nanomedicines can provide a novel, non-invasive therapeutic strategy for the more localised treatment of lung-resident diseases and potentially also enable the systemic delivery of therapeutics that are otherwise administered via injection alone. However, the clinical translation of inhalable nanomedicine is being hampered by our lack of understanding about their disposition and clearance from the lungs. This review provides a comprehensive overview of the biodegradable nanomaterials that are currently being explored as inhalable drug delivery systems and our current understanding of their disposition within, and clearance from the lungs. The safety of biodegradable nanomaterials in the lungs is discussed and latest updates are provided on the impact of inflammation on the pulmonary pharmacokinetics of inhaled nanomaterials. Overall, the review provides an in-depth and critical assessment of the lung clearance mechanisms for inhaled biodegradable nanomedicines and highlights the opportunities and challenges for their translation into the clinic. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Extragalactic and galactic sources: New evidence, new challenges, new opportunities

    Directory of Open Access Journals (Sweden)

    Kusenko Alexander

    2013-06-01

    Full Text Available Recent data bring in sharper focus the issue of relative contributions of galactic and extragalactic sources of ultrahigh-energy cosmic rays. On the one hand, there is some new evidence, from gamma-ray observations of blazars, that cosmic rays are, indeed, accelerated in AGNs. On the other hand, recent measurements of composition reported by Pierre Auger Observatory can be explained by a contribution of transient galactic sources, such as past GRBs and hypernovae, if nuclei accelerated in such events get trapped in the turbulent galactic magnetic fields. The likely contamination of UHECR data by the nuclei from past galactic stellar explosions creates new challenges for cosmic-ray astronomy. At the same time, it creates new opportunities for reconstructing galactic magnetic fields, understanding the history of transient galactic phenomena, and for using gamma rays to identify astrophysical nuclear accelerators outside Milky Way.

  11. Meta-synthesis of qualitative research: the challenges and opportunities.

    Science.gov (United States)

    Mohammed, Mohammed A; Moles, Rebekah J; Chen, Timothy F

    2016-06-01

    Synthesis of qualitative studies is an emerging area that has been gaining more interest as an important source of evidence for improving health care policy and practice. In the last decade there have been numerous attempts to develop methods of aggregating and synthesizing qualitative data. Although numerous empirical qualitative studies have been published about different aspects of health care research, to date, the aggregation and syntheses of these data has not been commonly reported, particularly in pharmacy practice related research. This paper describes different methods of conducting meta-synthesis and provides an overview of selected common methods. The paper also emphasizes the challenges and opportunities associated with conducting meta-synthesis and highlights the importance of meta-synthesis in informing practice, policy and research.

  12. Doomsday 2012 and Cosmophobia: Challenges and Opportunities for Science Communication

    Science.gov (United States)

    Fraknoi, A.; Larsen, K.; Mendez, B.; Morrison, D.; Van Stone, M.

    2013-04-01

    Hollywood movies, cable-channel documentaries, and countless books and websites have convinced a significant fraction of the U.S. public that some kind of catastrophe awaits us around the winter solstice of 2012, and that the cause of this catastrophe will be an astronomical or geophysical event. “Doomsday 2012” represents both a challenge and opportunity for science communication and education. This plenary panel discussed the basic ideas of the 2012 scenario and considered what is being done and what could be done to help the public understand what is real and what isn't. These lessons can be applied to future pseudoscientific predictions about the end of the world.

  13. European Socio-Economic Integration Challenges, Opportunities and Lessons Learned

    CERN Document Server

    Korres, George

    2013-01-01

    Economic integration is one of the most noteworthy issues in international economic policy at the end of the twentieth century. The recent examples of the European Union (EU) and the North American Free Trade Association (NAFTA) have raised important questions about the economic integration process and the possible establishment of economic unions in other parts of the world.  Against the backdrop of the financial crisis in Europe and prospects of increasing integration in Asia, this volume showcases research from an international array of researchers to provide a basic understanding of the current issues, problems, challenges, and opportunities for achieving integration, addressing both empirical and theoretical aspects of such topics as monetary union, social policy reform and social union, public finance and technology policy.  The chapters in Part 1 are focused primarily on economic issues, while Part 2 covers on social policy, the welfare state, and political reforms, with a particular emphasis on the ...

  14. CEST: From basic principles to applications, challenges and opportunities

    Science.gov (United States)

    Vinogradov, Elena; Sherry, A. Dean; Lenkinski, Robert E.

    2013-04-01

    Chemical Exchange Saturation Transfer (CEST) offers a new type of contrast for MRI that is molecule specific. In this approach, a slowly exchanging NMR active nucleus, typically a proton, possessing a chemical shift distinct from water is selectively saturated and the saturated spin is transferred to the bulk water via chemical exchange. Many molecules can act as CEST agents, both naturally occurring endogenous molecules and new types of exogenous agents. A large variety of molecules have been demonstrated as potential agents, including small diamagnetic molecules, complexes of paramagnetic ions, endogenous macromolecules, dendrimers and liposomes. In this review we described the basic principles of the CEST experiment, with emphasis on the similarity to earlier saturation transfer experiments described in the literature. Interest in quantitative CEST has also resulted in the development of new exchange-sensitive detection schemes. Some emerging clinical applications of CEST are described and the challenges and opportunities associated with translation of these methods to the clinical environment are discussed.

  15. Harnessing the market: The opportunities and challenges of privatization

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-01-01

    The decision to privatize comes from a policy determination that the Government no longer needs particular assets or no longer needs to be in control of all the means by which products or services are obtained or delivered. Most broadly defined, privatization substitutes, in whole or in part, private market mechanisms for the traditional Government role as employer, financier, owner, operator, and/or regulator of a product or service. This definition admits a wide variety of actions, from innovative contractual arrangements to outright divestiture of activities or assets. But all of these actions share common objectives: to remove the agency from those activities that are not inherently governmental functions or core business lines; to improve the management of remaining activities; to reduce the costs of doing business; and to shift greater performance and financial risk to the private sector. This report by the Privatization Working Group provides an indepth analysis of the major issues that surround privatization within the Department of Energy (DOE). The report divides privatization initiatives at the DOE into three major types: divestiture of functions, contracting out, and asset transfers. It includes the results of a survey of the entire DOE system that identifies more than 200 potential privatization opportunities. The report also includes 13 case studies that explore actual DOE privatization efforts over the past 2 years. Additionally, it summarizes the key legal authorities that govern each of the three types of privatization opportunities in the DOE. The report makes a series of recommendations and outlines accompanying actions that will help the DOE seize the opportunities presented by privatization and confront its challenges.

  16. The Data Issue: Opportunities and Challenges for Scientific Publishers

    Science.gov (United States)

    Murphy, F.; Irving, D. H.

    2011-12-01

    Using the recent report for the 'Opportunities in Data Exchange' Project produced by - and for - researchers, libraries/data centres and publishers (and which is based on a broad range of studies, questionnaires and evidence) we have defined current practices and expectations, and the gaps and dilemmas involved in producing data and datasets, and then analysed their relationship to formal publications. As a result, we identified potential opportunities to evolve scientific insights to be more useful and re-useful: with consequent implications for custodianship and long-term data management. We also defined a number of key incentives and barriers towards achieving these objectives. As a case study, the earth and environmental sciences have come under particularly close scrutiny with respect to data-ownership and -sharing arrangements, sometimes with damaging results to the discipline's reputation. These issues, along with considerable technological challenges, have to be handled effectively in order to best support all the users along the data chain. To that end, we show that key stakeholders - among them scientific publishers - need to have a clear idea of how to progress data-intensive derived information, which we demonstrate is often not the case. Towards bridging this knowledge gap, we have compiled a roadmap of next steps and key issues to be acknowledged and addressed by the scientific publishing community. These include: engaging directly with researchers, policy-makers, funding bodies and direct competitors to build innovative partnerships and enhance impact; providing technological and training investment and developing alongside the emerging discipline of 'data scientist': the 'data publisher'. This individual/company will need to combine a close understanding of researchers' priorities, together with market, legal and technical opportunities and restrictions.

  17. Mathematics and biology: The interface, challenges and opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Levin, S.A. [ed.] [Cornell Univ., Ithaca, NY (United States)

    1992-06-01

    The interface between mathematics and biology has long been a rich area of research, with mutual benefit to each supporting discipline. Traditional areas of investigation, such as population genetics, ecology, neurobiology, and 3-D reconstructions, have flourished, despite a rather meager environment for the funding of such work. In the past twenty years, the kind and scope of such interactions between mathematicians and biologists have changed dramatically, reaching out to encompass areas of both biology and mathematics that previously had not benefited. At the same time, with the closer integration of theory and experiment, and the increased reliance on high-speed computation, the costs of such research grew, though not the opportunities for funding. The perception became reinforced, both within the research community and at funding agencies, that although these interactions were expanding, they were not doing so at the rate necessary to meet the opportunities and needs. A workshop was held in Washington, DC, between April 28 and May 3, 1990 which drew together a broadly based group of researchers to synthesize conclusions from a group of working papers and extended discussions. The result is the report presented here, which we hope will provide a guide and stimulus to research in mathematical and computational biology for at least the next decade. The report identifies a number of grand challenges, representing a broad consensus among the participants.

  18. Chemical engineering challenges and investment opportunities in sustainable energy.

    Science.gov (United States)

    Heller, Adam

    2008-01-01

    The chemical and energy industries are transforming as they adjust to the new era of high-priced petroleum and severe global warming. As a result of the transformation, engineering challenges and investment opportunities abound. Rapid evolution and fast growth are expected in cathode and anode materials as well as polymeric electrolytes for vehicular batteries and in high-performance polymer-ceramic composites for wind turbines, fuel-efficient aircraft, and lighter and safer cars. Unique process-engineering opportunities exist in sand-oil, coal, and possibly also shale liquefaction to produce transportation fuel; and also in genetic engineering of photosynthesizing plants and other organisms for their processing into high-performance biodegradable polymers and high-value-added environmentally friendly chemicals. Also, research on the feasibility of mitigation of global warming through enhancement of CO(2) uptake by the southern oceans by fertilization with trace amounts of iron is progressing. Because chemical engineers are uniquely well trained in mathematical modeling of mass transport, flow, and mixing, and also in cost analysis, they are likely to join the oceanographers and marine biologists in this important endeavor.

  19. 21st century nursing practice in Ghana: challenges and opportunities.

    Science.gov (United States)

    Donkor, N T; Andrews, L D

    2011-06-01

    This article is intended to stimulate critical thinking and generate fruitful discussion on nursing practice in Ghana as experienced by the authors. Its rationale is to promote exchange of ideas and creative partnerships to ensure that right decisions are made in preparing competent, adaptable and resourceful nurses who can contribute to health for all in the 21st century. The challenges of nursing education, practice and migration in Ghana seem grim. There is inadequate capacity of training institutions, low staff morale, poor distribution and serious workforce shortages. Government reports and policy documents on nursing were sourced from official websites and reviewed and discussed in the context of the international scholarly published literature. The authors note that despite the severe crises, a number of opportunities such as improved home-based training, international nursing education partnerships and welfare and human resource development could foster effective nurse retention and managed migration. To address the issues with nursing health service delivery and nursing shortages in Ghana requires all stakeholders to move beyond the traditional stereotypes and be flexible and forward-looking. Needed policy options include expansion of local nursing education and training capacity, collaborative training opportunities, improving the welfare and retention rates of current staff and international exchange of nurse resources that is mutually beneficial to both source and sink countries. © 2011 The Authors. International Nursing Review © 2011 International Council of Nurses.

  20. Natural capital and bioeconomy: challenges and opportunities for forestry

    Directory of Open Access Journals (Sweden)

    Marco Marchetti

    2015-01-01

    Full Text Available Over the last decades, the stock of natural capital has been globally reduced by human-induced effects such as climate change, and land use and cover modifications. In particular, the continuous flow of goods and services from ecosystems to people is currently under threat if the current human activities still remain unsustainable. The recent bioeconomy strategy is an important opportunity to halt the loss of biodiversity and the reduction of services provision, from global to local scale. In this framework, forest sector plays a fundamental role in further enhancing the sustainable development and the green growth in degraded environments, such as marginal and rural areas. This paper provides an overview of the bioeconomy-based natural resources management (with a focus on forest ecosystems, by analyzing the related challenges and opportunities, from international to national perspective, as in Italy. At first, the role of forest sector in addressing the purposes of green growth is analyzed. Secondly, the most suitable tools to monitor and assess natural capital changes are described. Finally, the most important research contributions within the bioeconomy context are reported. To create the suitable conditions for bioeconomy and green growth, the following insights have to be denoted: (i a deeper understanding of natural capital and related changes; (ii the improvement of public participation in decision-making processes, especially at landscape scale; (iii the effective integration of ecological, socio-cultural, and economic dimensions while managing natural resources.

  1. The process of developing audiovisual patient information: challenges and opportunities.

    Science.gov (United States)

    Hutchison, Catherine; McCreaddie, May

    2007-11-01

    The aim of this project was to produce audiovisual patient information, which was user friendly and fit for purpose. The purpose of the audiovisual patient information is to inform patients about randomized controlled trials, as a supplement to their trial-specific written information sheet. Audiovisual patient information is known to be an effective way of informing patients about treatment. User involvement is also recognized as being important in the development of service provision. The aim of this paper is (i) to describe and discuss the process of developing the audiovisual patient information and (ii) to highlight the challenges and opportunities, thereby identifying implications for practice. A future study will test the effectiveness of the audiovisual patient information in the cancer clinical trial setting. An advisory group was set up to oversee the project and provide guidance in relation to information content, level and delivery. An expert panel of two patients provided additional guidance and a dedicated operational team dealt with the logistics of the project including: ethics; finance; scriptwriting; filming; editing and intellectual property rights. Challenges included the limitations of filming in a busy clinical environment, restricted technical and financial resources, ethical needs and issues around copyright. There were, however, substantial opportunities that included utilizing creative skills, meaningfully involving patients, teamworking and mutual appreciation of clinical, multidisciplinary and technical expertise. Developing audiovisual patient information is an important area for nurses to be involved with. However, this must be performed within the context of the multiprofessional team. Teamworking, including patient involvement, is crucial as a wide variety of expertise is required. Many aspects of the process are transferable and will provide information and guidance for nurses, regardless of specialty, considering developing this

  2. Wound Concerns and Healthcare Consumption of Resources after Colorectal Surgery: An Opportunity for Innovation?

    Science.gov (United States)

    Shah, Puja M; Evans, Heather L; Harrigan, Amy; Sawyer, Robert G; Friel, Charles M; Hedrick, Traci L

    2017-07-01

    Significant portions of patients undergoing colorectal surgical procedures have minor incision disturbances, yet very few meet definitions for surgical site infection (SSI). We sought to investigate the natural history of incision disturbances with a focus on the patient experience and resource utilization. We hypothesize that patients who have an incision disturbance consume frequent healthcare resources in the post-operative period despite the fact that most never receive a diagnosis of SSI. A 24-month prospective observational study was undertaken at an academic institution. Patients undergoing elective colorectal operation by two board-certified colorectal surgeons were followed prospectively for 90 days. Incisions were photographed serially and clinically characterized beginning as early as post-operative day two and at follow-up visits. The primary outcome was patient concern for an incision disturbance. Three surgeons reviewed clinical data and photographs to determine the presence of an incisional surgical infection, and diagnosis required agreement from two of three surgeons. There were 171 patients included; 31 (15%) sought evaluation from a healthcare provider for concerns related to their incision including 46 telephone calls, six emergency department visits, seven primary care visits, 10 home health and 40 surgical clinic visits. Incision erythema and drainage were the most common sources of patient concern. Mean body mass index was higher in patients with concern for incision disturbances (34 vs. 28 kg/m(2), p resources. This presents an opportunity for secure electronic communication with the surgical team and the patient to potentially reduce consumption of healthcare resources.

  3. Opportunities and challenges of nanotechnology in the green economy.

    Science.gov (United States)

    Iavicoli, Ivo; Leso, Veruscka; Ricciardi, Walter; Hodson, Laura L; Hoover, Mark D

    2014-10-07

    In a world of finite resources and ecosystem capacity, the prevailing model of economic growth, founded on ever-increasing consumption of resources and emission pollutants, cannot be sustained any longer. In this context, the "green economy" concept has offered the opportunity to change the way that society manages the interaction of the environmental and economic domains. To enable society to build and sustain a green economy, the associated concept of "green nanotechnology" aims to exploit nano-innovations in materials science and engineering to generate products and processes that are energy efficient as well as economically and environmentally sustainable. These applications are expected to impact a large range of economic sectors, such as energy production and storage, clean up-technologies, as well as construction and related infrastructure industries. These solutions may offer the opportunities to reduce pressure on raw materials trading on renewable energy, to improve power delivery systems to be more reliable, efficient and safe as well as to use unconventional water sources or nano-enabled construction products therefore providing better ecosystem and livelihood conditions.However, the benefits of incorporating nanomaterials in green products and processes may bring challenges with them for environmental, health and safety risks, ethical and social issues, as well as uncertainty concerning market and consumer acceptance. Therefore, our aim is to examine the relationships among guiding principles for a green economy and opportunities for introducing nano-applications in this field as well as to critically analyze their practical challenges, especially related to the impact that they may have on the health and safety of workers involved in this innovative sector. These are principally due to the not fully known nanomaterial hazardous properties, as well as to the difficulties in characterizing exposure and defining emerging risks for the workforce

  4. Toward evidence-based Chinese medicine: Status quo, opportunities and challenges.

    Science.gov (United States)

    Chen, Yao-Long; Zhao, Chen; Zhang, Li; Li, Bo; Wu, Chuan-Hong; Mu, Wei; Wang, Jia-Ying; Yang, Ke-Hu; Li, You-Ping; Chen, Chiehfeng; Wang, Yong-Yan; Wang, Chen; Bian, Zhao-Xiang; Shang, Hong-Cai

    2018-01-16

    How to test the treatments of Chinese medicine (CM) and make them more widely accepted by practitioners of Western medicine and the international healthcare community is a major concern for practitioners and researchers of CM. For centuries, various approaches have been used to identify and measure the efficacy and safety of CM. However, the high-quality evidence related to CM that produced in China is still rare. Over the recent years, evidence-based medicine (EBM) has been increasingly applied to CM, strengthening its theoretical basis. This paper reviews the past and present state of CM, analyzes the status quo, challenges and opportunities of basic research, clinical trials, systematic reviews, clinical practice guidelines and clinical pathways and evidence-based education developed or conducted in China, pointing out how EBM can help to make CM more widely used and recognized worldwide.

  5. Intimate partner violence, mental health disorders, and sexually transmitted infections: important screening opportunities for pediatric healthcare providers.

    Science.gov (United States)

    Pattishall, Amy E; Cruz, Mario; Spector, Nancy D

    2011-12-01

    This article addresses three critical areas where pediatric healthcare providers must employ effective screening techniques to ensure the best care for patients: intimate partner violence (IPV), mental health issues, and sexually transmitted infections (STIs). IPV is now recognized as an important issue impacting the health of children. While long-term outcomes secondary to positive screening results are not known, routine, sensitive questioning can identify at-risk children and help connect families to resources in the community. Routine use of validated screening tools for mental health disorders (MHDs) in the office setting is now recommended. STIs disproportionately affect adolescents and young adults, yet timely diagnosis is often challenging because infections are frequently asymptomatic and adolescents may not be forthcoming about risk-taking behaviors. There is significant opportunity for pediatricians to improve screening rates of adolescents. Screening is an essential aspect of healthcare for pediatricians. An understanding of current screening recommendations for IPV, MHDs, and STIs will assist providers in earlier detection of medical problems in their patients and will likely improve patient outcomes.

  6. International collaboration in mental health: Contributions, opportunities, and challenges

    Directory of Open Access Journals (Sweden)

    Pratap Sharan

    2016-01-01

    Full Text Available Introduction: Arising from the push for global health, the movement for global mental health has established itself as a distinct identity in the last few decades. Collaboration between donors, international agencies, institutions, and individuals of different countries has been an essential component in this endeavor. Methods: We review relevant reports in the literature that describe the process of collaboration between individuals and institutions in the area of mental health, in order to describe current patterns in international collaboration. Results and Discussion: In the last decade, international collaboration for mental health has increased substantially. Newer international professional associations; centers for global mental health at academic centers in Europe, USA, and Australia; and international health aid agencies have joined more established agencies, to provide platforms for collaboration. A number of priority-setting exercises have been undertaken that have stressed service development for mental health. International consortia for genetics and neuroimaging have demonstrated successful research collaboration. However, barriers to collaboration persist—these include a continuing failure to prioritize mental healthcare at a policy level, as well as difficulties in arriving at a consensus on conceptualization, transcultural issues, and priority-setting for mental health research. Going forward, the challenge for “global mental health” is to establish a framework that recognizes the unique contributions of all stakeholders and emphasizes equitable partnerships, while adapting knowledge across settings and health systems. Such an approach would be essential to achieve the stated aims of this movement.

  7. Social media in the healthcare context: Ethical challenges and ...

    African Journals Online (AJOL)

    The popularity of social media has grown rapidly and healthcare practitioners and students commonly use sites such as Facebook. The ethical and professional implications and their benefits and hazards must be considered. Concerns include blurring of boundaries between an individual's public and professional lives, ...

  8. Unpacking the Pacific Urban Agenda: Resilience Challenges and Opportunities

    Directory of Open Access Journals (Sweden)

    Gabriel Luke Kiddle

    2017-10-01

    Full Text Available Pacific Island Countries (PICs are often cited as being the most vulnerable to the future impacts of a changing climate. Furthermore, being located in the ‘Pacific Rim of Fire’, PICs have long been exposed to the impacts of a range of natural and climate-related extreme events—such as earthquakes and cyclones—and are considered to be amongst the most vulnerable countries to natural disasters. The physical vulnerability of Pacific towns and cities is further exaggerated by development deficits, geographical isolation, weak governance, and complex issues of land tenure. This paper, based on substantive project experience in the Pacific region by each of the authors, reviews the resilience challenges facing Melanesian cities in the context of rapid urbanization and global environmental change. It then sets this in the context of the global ‘New Urban Agenda’ which was launched at Habitat III in Quito at the end of 2016, setting out the critical implementation challenges and opportunities for enhancing urban resilience in the Pacific.

  9. Parasitic diseases: opportunities and challenges in the 21st century

    Directory of Open Access Journals (Sweden)

    Daniel G Colley

    2000-01-01

    Full Text Available The opportunities and challenges for the study and control of parasitic diseases in the 21st century are both exciting and daunting. Based on the contributions from this field over the last part of the 20th century, we should expect new biologic concepts will continue to come from this discipline to enrich the general area of biomedical research. The general nature of such a broad category of infections is difficult to distill, but they often depend on well-orchestrated, complex life cycles and they often involve chronic, relatively well-balanced host/parasite relationships. Such characteristics force biological systems to their limits, and this may be why studies of these diseases have made fundamental contributions to molecular biology, cell biology and immunology. However, if these findings are to continue apace, parasitologists must capitalize on the new findings being generated though genomics, bioinformatics, proteomics, and genetic manipulations of both host and parasite. Furthermore, they must do so based on sound biological insights and the use of hypothesis-driven studies of these complex systems. A major challenge over the next century will be to capitalize on these new findings and translate them into successful, sustainable strategies for control, elimination and eradication of the parasitic diseases that pose major public health threats to the physical and cognitive development and health of so many people worldwide.

  10. [School nutrition in 'quilombola' communities: challenges and opportunities].

    Science.gov (United States)

    de Sousa, Lucilene Maria; Martins, Karine Anusca; Cordeiro, Mariana de Morais; Monego, Estelamaris Tronco; da Silva, Simoni Urbano; Alexandre, Veruska Prado

    2013-04-01

    The Brazilian School Nutrition Program (PNAE) is a Food and Nutritional Security (SAN) strategy for public school students. This article seeks to discuss the challenges and opportunities of school nutrition in 'quilombola'* communities and report on the experience of the Cooperation Center for Student Food and Nutrition of the Federal University of Goiás and the Midwest Region (CECANE UFG/ Centro-Oeste). It includes a report on the experience with the systematization on PNAE, SAN and other policies. Continued access and adequate social policies are a challenge for the 'quilombola'* communities. Some economic, structural and social barriers have been identified in PNAE. In this context, Law 11.947/2009 encourages local development, with the acquisition of food from the region, and it establishes differentiated values per capita, which are translated into menus including products inherent to Afro-Brazilian culture that provide at least 30% of daily nutritional requirements. In the nutrition, health and quality of life project of 'quilombola'* schoolchildren, the CECANE UFG/Midwest carry out food and nutritional security actions. The area of school nutrition has proven responsive to local needs and supports the development and promotion of quality of life.

  11. Tsetse and trypanosomosis in Africa: the challenges, the opportunities.

    Science.gov (United States)

    Ilemobade, A A

    2009-03-01

    Tsetse-fly and the disease it transmits, trypanosomosis, remain an enormous disease challenge in the 37 countries of sub-Saharan Africa where the impact continues to be manifest in disease burden, increased level of poverty and decreased agricultural productivity. The impact also extends over an estimated 10 million km2 (a third of the African continent) of land area, a third of which contains some well-watered part of the continent, thus denying humans and livestock of potentially rich arable and pastureland. The disease is a threat to an estimated 50 million people and 48 million cattle with estimated annual losses in cattle production alone of 1-1.2 billion US$. These losses are due to stock mortality and depressed productivity, which may be of meat, milk, reproduction or traction. Beyond its direct effects on humans and livestock is its impact on African agriculture and the livelihood of the rural population in the affected countries: the fly and the disease influence where people decide to live, how they manage their livestock, and the intensity and the mix of crop agriculture. The combined effects result in changes in land use and environment which may, in turn, affect human welfare and increase the vulnerability of agricultural activity. Trypanosomosis is, therefore, both a public health and an agricultural development constraint. The challenges that the elimination or control of tsetse fly and trypanosomosis pose as well as the opportunities to develop appropriate intervention technologies are discussed in this presentation.

  12. Photovoice: an opportunity and challenge for students' genuine participation.

    Science.gov (United States)

    Warne, Maria; Snyder, Kristen; Gillander Gådin, Katja

    2013-09-01

    It has been highlighted that youth empowerment and participation are important principles for school health promotion. Despite this fact, children and youth are rarely given instruments to participate or to influence their situations and the environments in their schools. Photovoice is a method to increased empowerment and participation. Originally it was created as a community action research method based on Freire's critical pedagogy and feminist theory. The purpose of this study was to explore challenges and opportunities for applying photovoice in a school setting to support genuine participation. Together with teachers and students in an upper secondary school in Östersund's municipality in the north of Sweden, the photovoice method was field tested and modified to a classroom situation. The teachers and the students were interviewed about their experiences with the method. The results were interpreted by content analysis and showed that the teachers' capability to be facilitators and the students' possibility to make a difference for the school or the municipality were the most important factors to succeed with photovoice. The conclusions were that photovoice challenges schools and society to have a better structure for genuine participation if youth participation is seen as valuable.

  13. Nanotechnology Applications in Functional Foods; Opportunities and Challenges.

    Science.gov (United States)

    Singh, Harjinder

    2016-03-01

    Increasing knowledge on the link between diet and human health has generated a lot of interest in the development of functional foods. However, several challenges, including discovering of beneficial compounds, establishing optimal intake levels, and developing adequate food delivering matrix and product formulations, need to be addressed. A number of new processes and materials derived from nanotechnology have the potential to provide new solutions in many of these fronts. Nanotechnology is concerned with the manipulation of materials at the atomic and molecular scales to create structures that are less than 100 nm in size in one dimension. By carefully choosing the molecular components, it seems possible to design particles with different surface properties. Several food-based nanodelivery vehicles, such as protein-polysaccharide coacervates, multiple emulsions, liposomes and cochleates have been developed on a laboratory scale, but there have been very limited applications in real food systems. There are also public concerns about potential negative effects of nanotechnology-based delivery systems on human health. This paper provides an overview of the new opportunities and challenges for nanotechnology-based systems in future functional food development.

  14. Digitalizing historical high resolution water level data: Challenges and opportunities

    Science.gov (United States)

    Holinde, Lars; Hein, Hartmut; Barjenbruch, Ulrich

    2017-04-01

    Historical tide-gauge data offer the opportunities for determining variations in key characteristics for water level data and the analyses of past extreme events (storm surges). These information are important for calculating future trends and scenarios. But there are challenges involved due to the extensive effort needed to digitalize gauge sheets and quality control the resulting historical data. Based on these conditions, two main sources for inaccuracies in historical time series can be identified. First are several challenges due to the digitalization of the historical data, e.g. general quality of the sheets, multiple crossing lines of the observed water levels and additional comments on the sheet describing problems or additional information during the measurements. Second are problems during the measurements themselves. These can include the incorrect positioning of the sheets, trouble with the tide-gauge and maintenance. Errors resulting from these problems can be e.g. flat lines, discontinuities and outlier. Especially, the characterization of outliers has to be conducted carefully, to distinguish between real outliers and the appearance of extreme events. Methods for the quality control process involve the use of statistics, machine learning and neural networks. These will be described and applied to three different time series from tide gauge stations at the cost of Lower Saxony, Germany. Resulting difficulties and outcomes of the quality control process will be presented and explained. Furthermore, we will present a first glance at analyses for these time series.

  15. Synthetic Biology of Cyanobacteria: Unique Challenges and Opportunities

    Directory of Open Access Journals (Sweden)

    Bertram M Berla

    2013-08-01

    Full Text Available Photosynthetic organisms, and especially cyanobacteria, hold great promise as sources of renewably-produced fuels, bulk and specialty chemicals, and nutritional products. Synthetic biology tools can help unlock cyanobacteria’s potential for these functions, but unfortunately tool development for these organisms has lagged behind that for S. cerevisiae and E. coli. While these organisms may in many cases be more difficult to work with as ‘chassis’ strains for synthetic biology than certain heterotrophs, the unique advantages of autotrophs in biotechnology applications as well as the scientific importance of improved understanding of photosynthesis warrant the development of these systems into something akin to a ‘green E. coli’. In this review, we highlight unique challenges and opportunities for development of synthetic biology approaches in cyanobacteria. We review classical and recently developed methods for constructing targeted mutants in various cyanobacterial strains, and offer perspective on what genetic tools might most greatly expand the ability to engineer new functions in such strains. Similarly, we review what genetic parts are most needed for the development of cyanobacterial synthetic biology. Finally, we highlight recent methods to construct genome-scale models of cyanobacterial metabolism and to use those models to measure properties of autotrophic metabolism. Throughout this paper, we discuss some of the unique challenges of a diurnal, autotrophic lifestyle along with how the development of synthetic biology and biotechnology in cyanobacteria must fit within those constraints.

  16. Foreword: Follow-on Biologics: Implementation Challenges and Opportunities.

    Science.gov (United States)

    Paradise, Jordan

    2011-01-01

    This Book of the Seton Hall Law Review presents the contributions to Follow-On Biologics: Implementation Challenges and Opportunities, a one-day roundtable event hosted by Seton Hall University School of Law in the fall of 2010. The roundtable fostered an international dialogue regarding the future of follow-on biologics in the United States resulting from the Patient Protection and Affordable Care Act of March 2010. THE BIOLOGIC PRICE COMPETITION AND INNOVATION ACT OF 2010. The March 23, 2010, enactment of the Patient Protection and Affordable Care Act (PPACA) and the companion Health Care and Education Affordability Reconciliation Act of 2010 ushered in landmark reform of the American health care system. Along with sweeping overhauls of the health care system generally, PPACA also provides a new regulatory challenge for the Food and Drug Administration (FDA). A subtitle within PPACA, the Biologics Price Competition and Innovation Act (BPCIA), bestows upon FDA broad authority to implement an abbreviated approval route to market for biological products (also known as biologics) that are "biosimilar" to an existing marketed product. The brief introduction will provide a basic comparison of biologics and conventional pharmaceutical drugs that will prove central to the FDA's development of this follow-on biologic pathway as well as specifically examine the content and scope of the BPCIA provisions and identify future challenges for the FDA. It will conclude by highlighting details of presentations during the roundtable held at the Seton Hall University School of Law and introduce the two resulting articles contained with this Book of the Seton Hall Law Review.

  17. The challenges and opportunities in cumulative effects assessment

    Science.gov (United States)

    Foley, Melissa M.; Mease, Lindley A; Martone, Rebecca G; Prahler, Erin E; Morrison, Tiffany H; Clarke Murray, Cathryn; Wojcik, Deborah

    2016-01-01

    The cumulative effects of increasing human use of the ocean and coastal zone have contributed to a rapid decline in ocean and coastal resources. As a result, scientists are investigating how multiple, overlapping stressors accumulate in the environment and impact ecosystems. These investigations are the foundation for the development of new tools that account for and predict cumulative effects in order to more adequately prevent or mitigate negative effects. Despite scientific advances, legal requirements, and management guidance, those who conduct assessments—including resource managers, agency staff, and consultants—continue to struggle to thoroughly evaluate cumulative effects, particularly as part of the environmental assessment process. Even though 45 years have passed since the United States National Environmental Policy Act was enacted, which set a precedent for environmental assessment around the world, defining impacts, baseline, scale, and significance are still major challenges associated with assessing cumulative effects. In addition, we know little about how practitioners tackle these challenges or how assessment aligns with current scientific recommendations. To shed more light on these challenges and gaps, we undertook a comparative study on how cumulative effects assessment (CEA) is conducted by practitioners operating under some of the most well-developed environmental laws around the globe: California, USA; British Columbia, Canada; Queensland, Australia; and New Zealand. We found that practitioners used a broad and varied definition of impact for CEA, which led to differences in how baseline, scale, and significance were determined. We also found that practice and science are not closely aligned and, as such, we highlight opportunities for managers, policy makers, practitioners, and scientists to improve environmental assessment.

  18. Opportunities and Challenges for the Life Sciences Community

    Science.gov (United States)

    Stewart, Elizabeth; Ozdemir, Vural

    2012-01-01

    Abstract Twenty-first century life sciences have transformed into data-enabled (also called data-intensive, data-driven, or big data) sciences. They principally depend on data-, computation-, and instrumentation-intensive approaches to seek comprehensive understanding of complex biological processes and systems (e.g., ecosystems, complex diseases, environmental, and health challenges). Federal agencies including the National Science Foundation (NSF) have played and continue to play an exceptional leadership role by innovatively addressing the challenges of data-enabled life sciences. Yet even more is required not only to keep up with the current developments, but also to pro-actively enable future research needs. Straightforward access to data, computing, and analysis resources will enable true democratization of research competitions; thus investigators will compete based on the merits and broader impact of their ideas and approaches rather than on the scale of their institutional resources. This is the Final Report for Data-Intensive Science Workshops DISW1 and DISW2. The first NSF-funded Data Intensive Science Workshop (DISW1, Seattle, WA, September 19–20, 2010) overviewed the status of the data-enabled life sciences and identified their challenges and opportunities. This served as a baseline for the second NSF-funded DIS workshop (DISW2, Washington, DC, May 16–17, 2011). Based on the findings of DISW2 the following overarching recommendation to the NSF was proposed: establish a community alliance to be the voice and framework of the data-enabled life sciences. After this Final Report was finished, Data-Enabled Life Sciences Alliance (DELSA, www.delsall.org) was formed to become a Digital Commons for the life sciences community. PMID:22401659

  19. Opportunities and challenges for the life sciences community.

    Science.gov (United States)

    Kolker, Eugene; Stewart, Elizabeth; Ozdemir, Vural

    2012-03-01

    Twenty-first century life sciences have transformed into data-enabled (also called data-intensive, data-driven, or big data) sciences. They principally depend on data-, computation-, and instrumentation-intensive approaches to seek comprehensive understanding of complex biological processes and systems (e.g., ecosystems, complex diseases, environmental, and health challenges). Federal agencies including the National Science Foundation (NSF) have played and continue to play an exceptional leadership role by innovatively addressing the challenges of data-enabled life sciences. Yet even more is required not only to keep up with the current developments, but also to pro-actively enable future research needs. Straightforward access to data, computing, and analysis resources will enable true democratization of research competitions; thus investigators will compete based on the merits and broader impact of their ideas and approaches rather than on the scale of their institutional resources. This is the Final Report for Data-Intensive Science Workshops DISW1 and DISW2. The first NSF-funded Data Intensive Science Workshop (DISW1, Seattle, WA, September 19-20, 2010) overviewed the status of the data-enabled life sciences and identified their challenges and opportunities. This served as a baseline for the second NSF-funded DIS workshop (DISW2, Washington, DC, May 16-17, 2011). Based on the findings of DISW2 the following overarching recommendation to the NSF was proposed: establish a community alliance to be the voice and framework of the data-enabled life sciences. After this Final Report was finished, Data-Enabled Life Sciences Alliance (DELSA, www.delsall.org ) was formed to become a Digital Commons for the life sciences community.

  20. YOUTH LABOUR MARKET. MOBILITY, CAREER DEVELOPMENT, INCOMES. CHALLENGES AND OPPORTUNITIES

    Directory of Open Access Journals (Sweden)

    Vasile Liviu

    2011-07-01

    Full Text Available This paper presents the main characteristics of the youth labour market, with a special view on mobility, career development and incomes. The paper is substantiated by and continues the researches of the authors on the topic of labour force mobility and on the one of adaptability, respectively on youths' beahviour on labour market (with particular consideration of young graduates highlighting the factors that adjust choices regarding taking up a job, career advancement, labour motivation, professional and personal satisfaction opportunities which are provided by the labour market at local level, in country and abroad. Quantitative and qualitative indicators are presented about Romanian youths' labour market within the European context during the transition period. The impact of the crisis on youths' labour market is analysed, highlighting the challenges and opportunities, the particularities of the newly created jobs and especially the knowledge, skills and competencies requirements (KSC. The authors propose both the improvement of the systems of indicators for defining the potential and presence of youth on the labour market, the economic and social impact of external mobility of young graduates and an integrated scheme of policy measures for promoting adaptability and performance integration on Romanian labour market of youth. Particular attention is paid to presenting policy instruments for halting/diminishing the brain drain and brain shopping phenomena by promoting an attractive (professionally and monetary supply for employment in Romania's local economy. The authors succeed in highlighting the functional links between the education market (labour force supply and labour market (employment demand of the business environment underpinning the requirement of integrated management of labour potential in the years preceding studies' finalization and up to the post-insertion years by multi-criteria analysis models and graduate career tracking

  1. Smart services – characteristics, challenges, opportunities and business models

    Directory of Open Access Journals (Sweden)

    Marquardt Katrin

    2017-07-01

    Full Text Available “Industry 4.0”, “Digitalization”, “Internet of Things” and “Smart Services” are the today’s buzzwords when tracking economic news. It is to ask about the meaning of those phrases. The world has changed over the last decade from a mainly physical to software controlled economy and the information technology has become an integral part of our industry and society in its entirety. Nowadays it is no longer the product that matters it is the data that are generated by using the product or service. Those usage data collected and analyzed commence new business models and services. The economic future of a company will much more rely on the ability to collect and use the data to generate Smart Services for their customers and to transform from a simple product supplier to an entertainment provider. However there are not only opportunities there are also challenges on the way to that new services which needs to be known and considered. For instance the development cycles need to be faster, the business models need to be adjusted and the positive financial results will not come into the picture on the first day. Based on those thoughts and while there only a handful of researches about that new services exists, the main purpose of the present study is at first, to gain a common understanding about the meaning and the characteristics of Smart Services and their adjacencies. Secondly, the study summarizes the identified challenges and opportunities in relation to them. Thirdly, the author introduce and explain the main business models usable for those Smart Services and the requirements for starting the transformation towards those services. The aim of this paper is to set a basis for this exciting and relatively unsought topic and to produce an interest in further empirical and practical researches in this area. The methodologies used for this research are a systematic literature review and an evaluation of existing studies with the

  2. A new approach to wind energy: Opportunities and challenges

    Science.gov (United States)

    Dabiri, John O.; Greer, Julia R.; Koseff, Jeffrey R.; Moin, Parviz; Peng, Jifeng

    2015-03-01

    Despite common characterizations of modern wind energy technology as mature, there remains a persistent disconnect between the vast global wind energy resource—which is 20 times greater than total global power consumption—and the limited penetration of existing wind energy technologies as a means for electricity generation worldwide. We describe an approach to wind energy harvesting that has the potential to resolve this disconnect by geographically distributing wind power generators in a manner that more closely mirrors the physical resource itself. To this end, technology development is focused on large arrays of small wind turbines that can harvest wind energy at low altitudes by using new concepts of biology-inspired engineering. This approach dramatically extends the reach of wind energy, as smaller wind turbines can be installed in many places that larger systems cannot, especially in built environments. Moreover, they have lower visual, acoustic, and radar signatures, and they may pose significantly less risk to birds and bats. These features can be leveraged to attain cultural acceptance and rapid adoption of this new technology, thereby enabling significantly faster achievement of state and national renewable energy targets than with existing technology alone. Favorable economics stem from an orders-of-magnitude reduction in the number of components in a new generation of simple, mass-manufacturable (even 3D-printable), vertical-axis wind turbines. However, this vision can only be achieved by overcoming significant scientific challenges that have limited progress over the past three decades. The following essay summarizes our approach as well as the opportunities and challenges associated with it, with the aim of motivating a concerted effort in basic and applied research in this area.

  3. Hydrological connectivity for riverine fish: measurement challenges and research opportunities

    Science.gov (United States)

    Fullerton, A.H.; Burnett, K.M.; Steel, E.A.; Flitcroft, R.L.; Pess, G.R.; Feist, B.E.; Torgersen, C.E.; Miller, D.J.; Sanderson, B.L.

    2010-01-01

    1. In this review, we first summarize how hydrologic connectivity has been studied for riverine fish capable of moving long distances, and then identify research opportunities that have clear conservation significance. Migratory species, such as anadromous salmonids, are good model organisms for understanding ecological connectivity in rivers because the spatial scale over which movements occur among freshwater habitats is large enough to be easily observed with available techniques; they are often economically or culturally valuable with habitats that can be easily fragmented by human activities; and they integrate landscape conditions from multiple surrounding catchment(s) with in-river conditions. Studies have focussed on three themes: (i) relatively stable connections (connections controlled by processes that act over broad spatio-temporal scales >1000 km2 and >100 years); (ii) dynamic connections (connections controlled by processes acting over fine to moderate spatio-temporal scales -1-1000 km2 and ecology, organized under three foci: (i) addressing the constraints of river structure; (ii) embracing temporal complexity in hydrologic connectivity; and (iii) managing connectivity for riverine fishes. Challenges include the spatial structure of stream networks, the force and direction of flow, scale-dependence of connectivity, shifting boundaries, complexity of behaviour and life histories and quantifying anthropogenic influence on connectivity and aligning management goals. As we discuss each challenge, we summarize relevant approaches in the literature and provide additional suggestions for improving research and management of connectivity for riverine fishes. 3. Specifically, we suggest that rapid advances are possible in the following arenas: (i) incorporating network structure and river discharge into analyses; (ii) increasing explicit consideration of temporal complexity and fish behaviour in the scope of analyses; and (iii) parsing degrees of human and

  4. Opportunities and challenges of high-performance computing in chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Guest, M.F.; Kendall, R.A.; Nichols, J.A. [eds.] [and others

    1995-06-01

    The field of high-performance computing is developing at an extremely rapid pace. Massively parallel computers offering orders of magnitude increase in performance are under development by all the major computer vendors. Many sites now have production facilities that include massively parallel hardware. Molecular modeling methodologies (both quantum and classical) are also advancing at a brisk pace. The transition of molecular modeling software to a massively parallel computing environment offers many exciting opportunities, such as the accurate treatment of larger, more complex molecular systems in routine fashion, and a viable, cost-effective route to study physical, biological, and chemical `grand challenge` problems that are impractical on traditional vector supercomputers. This will have a broad effect on all areas of basic chemical science at academic research institutions and chemical, petroleum, and pharmaceutical industries in the United States, as well as chemical waste and environmental remediation processes. But, this transition also poses significant challenges: architectural issues (SIMD, MIMD, local memory, global memory, etc.) remain poorly understood and software development tools (compilers, debuggers, performance monitors, etc.) are not well developed. In addition, researchers that understand and wish to pursue the benefits offered by massively parallel computing are often hindered by lack of expertise, hardware, and/or information at their site. A conference and workshop organized to focus on these issues was held at the National Institute of Health, Bethesda, Maryland (February 1993). This report is the culmination of the organized workshop. The main conclusion: a drastic acceleration in the present rate of progress is required for the chemistry community to be positioned to exploit fully the emerging class of Teraflop computers, even allowing for the significant work to date by the community in developing software for parallel architectures.

  5. Mechanics of the brain: perspectives, challenges, and opportunities.

    Science.gov (United States)

    Goriely, Alain; Geers, Marc G D; Holzapfel, Gerhard A; Jayamohan, Jayaratnam; Jérusalem, Antoine; Sivaloganathan, Sivabal; Squier, Waney; van Dommelen, Johannes A W; Waters, Sarah; Kuhl, Ellen

    2015-10-01

    The human brain is the continuous subject of extensive investigation aimed at understanding its behavior and function. Despite a clear evidence that mechanical factors play an important role in regulating brain activity, current research efforts focus mainly on the biochemical or electrophysiological activity of the brain. Here, we show that classical mechanical concepts including deformations, stretch, strain, strain rate, pressure, and stress play a crucial role in modulating both brain form and brain function. This opinion piece synthesizes expertise in applied mathematics, solid and fluid mechanics, biomechanics, experimentation, material sciences, neuropathology, and neurosurgery to address today's open questions at the forefront of neuromechanics. We critically review the current literature and discuss challenges related to neurodevelopment, cerebral edema, lissencephaly, polymicrogyria, hydrocephaly, craniectomy, spinal cord injury, tumor growth, traumatic brain injury, and shaken baby syndrome. The multi-disciplinary analysis of these various phenomena and pathologies presents new opportunities and suggests that mechanical modeling is a central tool to bridge the scales by synthesizing information from the molecular via the cellular and tissue all the way to the organ level.

  6. Dispersal in a changing world: opportunities, insights and challenges.

    Science.gov (United States)

    Tesson, Sylvie Vm; Edelaar, Pim

    2013-01-01

    It has been long recognised that dispersal is an important life-history trait that plays a key role in the demography and evolution of populations and species. This then suggests that dispersal play a central role in the response of populations and species to ever-increasing global change, including climate change, habitat loss and fragmentation, and biological invasions. During a symposium held at Lund University (Sweden), the causes and consequences of dispersal were discussed, and here we provide an overview of the talks. As the discussions often gravitated towards the role and our understanding of dispersal in a changing world and given the urgent challenges posed by it, we place this overview in the context of global change. We draw and discuss four conclusions: (i) methodological advances provide opportunities for improved future studies, (ii) dispersal distances can be much greater than previously thought (examples in plants and vertebrates), but also much more restricted (examples in micro-organisms), (iii) dispersal is more dynamic than we often care to admit (e.g. due to individual variation, effects of parasites, variation in life history, developmental and evolutionary responses, community impacts), (iv) using results of dispersal research for detailed prediction of outcomes under global change is currently mostly out of reach - nevertheless, that should not stop us from showing the many negative consequences of global change, and how dispersal is often a limiting factor in adapting to this.

  7. GLOBALIZATION AND SMALL BUSINESSES AND ECONOMIES – CHALLENGES AND OPPORTUNITIES

    Directory of Open Access Journals (Sweden)

    NINKO KOSTOVSKI

    2016-08-01

    Full Text Available In this paper, we analyze the effect of globalization in general and from the viewpoint of the small and medium sized companies in the Republic of Macedonia, as a typical developing economy. Our survey of 100 managers and business owners from small and medium sized enterprises indicates that they tend to perceive the globalization with more conservative glasses as negative, or at the best, as a neutral phenomenon to their overall business prospects. However, to harvest the apparent opportunities of the globalization and to achieve the desired internationalization of their businesses, they call for intensive regional cooperation seeing it as a gateway to much harsher realms of the globalized market. The literature review and the examples from some other countries support these conservative standing of our managers and offer practical explanations why the approach towards the globalization is conservative and often even negative. Small business is important provider of new jobs, ideas and business concepts. However, with the opening of the global market it is a constant pursue for customers all around the world, having to meet their diverse and rapidly changing needs and facing extremely shortened delivery terms and product lifecycles. Many small companies, particularly from the developing countries are not adequately prepared to face the reality of this challenge. On the other hand, the big multinational companies receive more than hefty incentives to invest into the developing countries and that creates additional negative sentiments towards the globalization among the local companies.

  8. 2D Materials for Optical Modulation: Challenges and Opportunities.

    Science.gov (United States)

    Yu, Shaoliang; Wu, Xiaoqin; Wang, Yipei; Guo, Xin; Tong, Limin

    2017-04-01

    Owing to their atomic layer thickness, strong light-material interaction, high nonlinearity, broadband optical response, fast relaxation, controllable optoelectronic properties, and high compatibility with other photonic structures, 2D materials, including graphene, transition metal dichalcogenides and black phosphorus, have been attracting increasing attention for photonic applications. By tuning the carrier density via electrical or optical means that modifies their physical properties (e.g., Fermi level or nonlinear absorption), optical response of the 2D materials can be instantly changed, making them versatile nanostructures for optical modulation. Here, up-to-date 2D material-based optical modulation in three categories is reviewed: free-space, fiber-based, and on-chip configurations. By analysing cons and pros of different modulation approaches from material and mechanism aspects, the challenges faced by using these materials for device applications are presented. In addition, thermal effects (e.g., laser induced damage) in 2D materials, which are critical to practical applications, are also discussed. Finally, the outlook for future opportunities of these 2D materials for optical modulation is given. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Network models of frugivory and seed dispersal: Challenges and opportunities

    Science.gov (United States)

    Carlo, Tomás A.; Yang, Suann

    2011-11-01

    Network analyses have emerged as a new tool to study frugivory and seed dispersal (FSD) mutualisms because networks can model and simplify the complexity of multiple community-wide species interactions. Moreover, network theory suggests that structural properties, such as the presence of highly generalist species, are linked to the stability of mutualistic communities. However, we still lack empirical validation of network model predictions. Here we outline new research avenues to connect network models to FSD processes, and illustrate the challenges and opportunities of this tool with a field study. We hypothesized that generalist frugivores would be important for forest stability by dispersing seeds into deforested areas and initiating reforestation. We then constructed a network of plant-frugivore interactions using published data and identified the most generalist frugivores. To test the importance of generalists we measured: 1) the frequency with which frugivores moved between pasture and forest, 2) the bird-generated seed rain under perches in the pasture, and 3) the perching frequency of birds above seed traps. The generalist frugivores in the forest network were not important for seed dispersal into pastures, and thus for forest recovery, because the forest network excluded habitat heterogeneities, frugivore behavior, and movements. More research is needed to develop ways to incorporate relevant FSD processes into network models in order for these models to be more useful to community ecology and conservation. The network framework can serve to spark and renew interest in FSD and further our understanding of plant-animal communities.

  10. Challenges and opportunities of biodegradable plastics: A mini review.

    Science.gov (United States)

    Rujnić-Sokele, Maja; Pilipović, Ana

    2017-02-01

    The concept of materials coming from nature with environmental advantages of being biodegradable and/or biobased (often referred to as bioplastics) is very attractive to the industry and to the consumers. Bioplastics already play an important role in the fields of packaging, agriculture, gastronomy, consumer electronics and automotive, but still they have a very low share in the total production of plastics (currently about 1% of the about 300 million tonnes of plastic produced annually). Biodegradable plastics are often perceived as the possible solution for the waste problem, but biodegradability is just an additional feature of the material to be exploited at the end of its life in specific terms, in the specific disposal environment and in a specific time, which is often forgotten. They should be used as a favoured choice for the applications that demand a cheap way to dispose of the item after it has fulfilled its job (e.g. for food packaging, agriculture or medical products). The mini-review presents the opportunities and future challenges of biodegradable plastics, regarding processing, properties and waste management options.

  11. Mechanisms of motivation–cognition interaction: challenges and opportunities

    Science.gov (United States)

    Krug, Marie K.; Chiew, Kimberly S.; Kool, Wouter; Westbrook, J. Andrew; Clement, Nathan J.; Adcock, R. Alison; Barch, Deanna M.; Botvinick, Matthew M.; Carver, Charles S.; Cools, Roshan; Custers, Ruud; Dickinson, Anthony; Dweck, Carol S.; Fishbach, Ayelet; Gollwitzer, Peter M.; Hess, Thomas M.; Isaacowitz, Derek M.; Mather, Mara; Murayama, Kou; Pessoa, Luiz; Samanez-Larkin, Gregory R.; Somerville, Leah H.

    2016-01-01

    Recent years have seen a rejuvenation of interest in studies of motivation–cognition interactions arising from many different areas of psychology and neuroscience. The present issue of Cognitive, Affective, & Behavioral Neuroscience provides a sampling of some of the latest research from a number of these different areas. In this introductory article, we provide an overview of the current state of the field, in terms of key research developments and candidate neural mechanisms receiving focused investigation as potential sources of motivation–cognition interaction. However, our primary goal is conceptual: to highlight the distinct perspectives taken by different research areas, in terms of how motivation is defined, the relevant dimensions and dissociations that are emphasized, and the theoretical questions being targeted. Together, these distinctions present both challenges and opportunities for efforts aiming toward a more unified and cross-disciplinary approach. We identify a set of pressing research questions calling for this sort of cross-disciplinary approach, with the explicit goal of encouraging integrative and collaborative investigations directed toward them. PMID:24920442

  12. ABA and cytokinins: challenge and opportunity for plant stress research.

    Science.gov (United States)

    Verslues, Paul E

    2016-08-01

    Accumulation of the stress hormone abscisic acid (ABA) induces many cellular mechanisms associated with drought resistance. Recent years have seen a rapid advance in our knowledge of how increased ABA levels are perceived by ABA receptors, particularly the PYL/RCAR receptors, but there has been relatively less new information about how ABA accumulation is controlled and matched to stress severity. ABA synthesis and catabolism, conjugation and deconjugation to glucose, and ABA transport all are involved in controlling ABA levels. This highly buffered system of ABA metabolism represents both a challenge and opportunity in developing a mechanistic understanding of how plants detect and respond to drought. Recent data have also shown that direct manipulation of cytokinin levels in transgenic plants has dramatic effect on drought phenotypes and prompted new interest in the role of cytokinins and cytokinin signaling in drought. Both ABA and cytokinins will continue to be major foci of drought research but likely with different trajectories both in terms of basic research and in translational research aimed at increasing plant performance during drought.

  13. Preparing for Change: Challenges and Opportunities in a Global World

    Science.gov (United States)

    O'Hara, Sabine

    2009-03-01

    Our world is becoming increasingly global. This may sound like a clich'e, yet it is true nonetheless, and poses unprecedented challenges for graduate education. For the new generation of researchers, teachers and professionals to be successful they must be prepared in more than the content area of their chosen field. They must also acquire proficiency in global awareness, cultural literacy, multicultural teamwork and language facility. These global skill sets form the basis for effective multicultural collaboration and will become increasingly important even for those who do not intend to study or work abroad. Knowledge has become more portable in the internet age; large data bases and reports can be accessed in real time from various locations around the globe; information is exchanged in multifaceted knowledge networks; collaborative research takes place within and outside of the traditional venue of the research university in the private sector, research institutes, and associations; research networks span multiple disciplines as progress invariably occurs at the intersection of previously discrete fields of inquiry. Global collaboration thus is no longer dependent on the physical proximity of collaborators but can take place anywhere any time. This then requires yet another set of skills, namely the ability to adapt to change, exhibit flexibility and transfer skills to a range of contexts and applications. Effective graduate education must address these realities and expose students to learning opportunities that will enable them to acquire these much needed global skills sets.

  14. Wearable Training-Monitoring Technology: Applications, Challenges, and Opportunities.

    Science.gov (United States)

    Cardinale, Marco; Varley, Matthew C

    2017-04-01

    The need to quantify aspects of training to improve training prescription has been the holy grail of sport scientists and coaches for many years. Recently, there has been an increase in scientific interest, possibly due to technological advancements and better equipment to quantify training activities. Over the last few years there has been an increase in the number of studies assessing training load in various athletic cohorts with a bias toward subjective reports and/or quantifications of external load. There is an evident lack of extensive longitudinal studies employing objective internal-load measurements, possibly due to the cost-effectiveness and invasiveness of measures necessary to quantify objective internal loads. Advances in technology might help in developing better wearable tools able to ease the difficulties and costs associated with conducting longitudinal observational studies in athletic cohorts and possibly provide better information on the biological implications of specific external-load patterns. Considering the recent technological developments for monitoring training load and the extensive use of various tools for research and applied work, the aim of this work was to review applications, challenges, and opportunities of various wearable technologies.

  15. Group IV direct band gap photonics: Methods, Challenges and Opportunities

    Directory of Open Access Journals (Sweden)

    Richard eGeiger

    2015-07-01

    Full Text Available The concept of direct band gap group IV materials offers a paradigm change for Si-photonics concerning the monolithic implementation of light emitters: The idea is to integrate fully compatible group IV materials with equally favorable optical properties as the chemically incompatible group III-V-based systems. The concept involves either mechanically applied strain on Ge or alloying of Ge with Sn and permits to drastically improve the insufficient radiative efficiency of Ge. The favorable optical properties result from a modified band structure transformed from an indirect to a direct one. The first demonstration of such a direct band gap laser, accomplished in GeSn, exemplifies the capability of this new concept. These systems may permit a qualitative as well as a quantitative expansion of Si-photonics into traditional but also new areas of applications, provided they can be operated energy efficiently, under ambient conditions and integrated with current Si technologies. This review aims to discuss the challenges along this path in terms of fabrication, characterization and fundamental understanding, and will elaborate on evoking opportunities of this new class of group IV-based laser materials.

  16. Exposed medical staff: challenges, available tools, and opportunities for improvement.

    Science.gov (United States)

    Dauer, Lawrence T

    2014-02-01

    Medical staff doses have increased over the past decade, as there is an increasing need for the benefits and use of radiation in medicine. While current average medical staff doses are well within limits, some doses to individuals could exceed 20 mSv y deep dose equivalent or lens dose equivalent (if unprotected), and there is the potential for some workers to exceed 500 mSv y shallow dose equivalent without careful assessment and protection. Nuclear medicine radiochemistry and patient dose preparation present challenging opportunities for improved dose control. In addition, fluoroscopically guided intervention procedures continue to represent an important area for careful protection implementation. Optimization of radiation protection in the medical setting should include tried and true principles of justification, optimization, and limitation with emphasis on training, credentialing, planning, and quality management. As newer and developing uses of radiation in medicine are tested and implemented, it is important to consider effective dosimetric monitoring, lens of eye doses, extremity doses, novel uses, and novel radionuclide characteristics. An ongoing assessment of current and future patterns of use for radiation in medicine is an essential activity to assist in prioritizing limited resources for staff protection. Introduction of Exposed Medical Staff (Video 1:27, http://links.lww.com/HP/A20).

  17. [Health Care for Refugees: Challenges and Opportunities in Hamburg].

    Science.gov (United States)

    Jakubowski, Elke; Rau, Cornelius; Quellhorst, Sibylle; Sothmann, Peter; Plenge-Bönig, Anita; Niessen, Johannes

    2017-08-01

    The massive increase in the number of refugees represents a great challenge to German cities. In Hamburg, 40 868 asylum seekers were registered in 2015, of which 22 315 remained in the city. The goal of the health administration is to provide primary medical care in response to specific health risks and needs of refugees while allowing them to be swiftly integrated into the standard health care system. Public authorities, charities and civil society are working hand in hand. In all reception centres in Hamburg, medical consultations with translation services are offered in fully equipped medical container practices. For every 1 000 refugees, a full-time doctor and a medical assistant are available. In addition to contractual staff, employees of contractually integrated hospitals are participating in the provision of medical care. Systematic collection of data on the health condition of the refugees as well as strengthening public health services are key factors in the planning and improvement of services in the future. Healthier living conditions and access to the standard health care system provide an opportunity to facilitate successful integration of refugees into society. © Georg Thieme Verlag KG Stuttgart · New York.

  18. China's meat industry revolution: challenges and opportunities for the future.

    Science.gov (United States)

    Zhou, Guanghong; Zhang, Wangang; Xu, Xinglian

    2012-11-01

    From a very limited ration of meat only for urban citizens to the world's largest meat-producing country, from a handful of processing facilities in major cities to thousands of modern meat packing and processing plants throughout the country, the Chinese meat industry has gone through drastic revolutionary changes particularly in the last three decades. Before the national economic reform in the late 1970s, meat production in China was extremely limited; hence, meat was rationed, treated as a highly precious food, and was highly valued. However, new processing technology developments, as related to meat animal production, slaughtering, processing, and distribution have transformed the inefficient Chinese meat industry that prepared only a handful of traditional products into a vast enterprise today that is manufacturing a huge variety of fresh and further processed items enjoyed by the average Chinese household. Along with this evolution, there has been the emergence of mega-scale meat companies and rapid advances in meat science and technology that address many aspects of meat. This review will highlight some milestone changes of the Chinese meat industry and discuss challenges and opportunities ahead in the global market for China. Copyright © 2012. Published by Elsevier Ltd.

  19. Ownership of heritage resources in South Africa: challenges and opportunities

    Directory of Open Access Journals (Sweden)

    Ndukuyakhe Ndlovu

    2013-03-01

    Full Text Available The concept of ownership is highly political. Ownership provides power to the one legally seen as an owner or those tasked with the responsibility to protect and preserve heritage resources. This is no different when it comes to heritage resources, whose ownership is always contentious. The main reason for such contention is because ownership impacts on those who value objects in different ways. For example, the nature of access to heritage resources approved for people who may still attach spiritual values. As a direct result, the relevance of such heritage resources to such people may be brought into question, as the need to have them available to all citizens gain momentum. Heritage resources in South Africa have been subject to legislation since 1911, when the Bushmen Relics Act was passed. Since then, much other legislation and amendments have been passed over the years. They all aim to protect different kinds of heritage resources. Central to protection efforts is a decision to have the ownership of heritage resources put under the national estate. Ownership of heritage under South African heritage legislation will be discussed in this article. Drawing on case studies from southern Africa, the main aim of the article is to identify the challenges and opportunities attached to such a form of ownership. Opinions relating to the best approach to ownership of heritage resources are offered.

  20. Robotic surgery in cancer care: opportunities and challenges.

    Science.gov (United States)

    Mohammadzadeh, Niloofar; Safdari, Reza

    2014-01-01

    Malignancy-associated mortality, decreased productivity, and spiritual, social and physical burden in cancer patients and their families impose heavy costs on communities. Therefore cancer prevention, early detection, rapid diagnosis and timely treatment are very important. Use of modern methods based on information technology in cancer can improve patient survival and increase patient and health care provider satisfaction. Robot technology is used in different areas of health care and applications in surgery have emerged affecting the cancer treatment domain. Computerized and robotic devices can offer enhanced dexterity by tremor abolition, motion scaling, high quality 3D vision for surgeons and decreased blood loss, significant reduction in narcotic use, and reduced hospital stay for patients. However, there are many challenges like lack of surgical community support, large size, high costs and absence of tactile and haptic feedback. A comprehensive view to identify all factors in different aspects such as technical, legal and ethical items that prevent robotic surgery adoption is thus very necessary. Also evidence must be presented to surgeons to achieve appropriate support from physicians. The aim of this review article is to survey applications, opportunities and barriers to this advanced technology in patients and surgeons as an approach to improve cancer care.

  1. Challenges and Opportunities in Developing Respiratory Syncytial Virus Therapeutics

    Science.gov (United States)

    Simões, Eric A. F.; DeVincenzo, John P.; Boeckh, Michael; Bont, Louis; Crowe, James E.; Griffiths, Paul; Hayden, Frederick G.; Hodinka, Richard L.; Smyth, Rosalind L.; Spencer, Keith; Thirstrup, Steffen; Walsh, Edward E.; Whitley, Richard J.

    2015-01-01

    Two meetings, one sponsored by the Wellcome Trust in 2012 and the other by the Global Virology Foundation in 2013, assembled academic, public health and pharmaceutical industry experts to assess the challenges and opportunities for developing antivirals for the treatment of respiratory syncytial virus (RSV) infections. The practicalities of clinical trials and establishing reliable outcome measures in different target groups were discussed in the context of the regulatory pathways that could accelerate the translation of promising compounds into licensed agents. RSV drug development is hampered by the perceptions of a relatively small and fragmented market that may discourage major pharmaceutical company investment. Conversely, the public health need is far too large for RSV to be designated an orphan or neglected disease. Recent advances in understanding RSV epidemiology, improved point-of-care diagnostics, and identification of candidate antiviral drugs argue that the major obstacles to drug development can and will be overcome. Further progress will depend on studies of disease pathogenesis and knowledge provided from controlled clinical trials of these new therapeutic agents. The use of combinations of inhibitors that have different mechanisms of action may be necessary to increase antiviral potency and reduce the risk of resistance emergence. PMID:25713060

  2. Engineering and physical sciences in oncology: challenges and opportunities.

    Science.gov (United States)

    Mitchell, Michael J; Jain, Rakesh K; Langer, Robert

    2017-11-01

    The principles of engineering and physics have been applied to oncology for nearly 50 years. Engineers and physical scientists have made contributions to all aspects of cancer biology, from quantitative understanding of tumour growth and progression to improved detection and treatment of cancer. Many early efforts focused on experimental and computational modelling of drug distribution, cell cycle kinetics and tumour growth dynamics. In the past decade, we have witnessed exponential growth at the interface of engineering, physics and oncology that has been fuelled by advances in fields including materials science, microfabrication, nanomedicine, microfluidics, imaging, and catalysed by new programmes at the National Institutes of Health (NIH), including the National Institute of Biomedical Imaging and Bioengineering (NIBIB), Physical Sciences in Oncology, and the National Cancer Institute (NCI) Alliance for Nanotechnology. Here, we review the advances made at the interface of engineering and physical sciences and oncology in four important areas: the physical microenvironment of the tumour and technological advances in drug delivery; cellular and molecular imaging; and microfluidics and microfabrication. We discussthe research advances, opportunities and challenges for integrating engineering and physical sciences with oncology to develop new methods to study, detect and treat cancer, and we also describe the future outlook for these emerging areas.

  3. Challenges and opportunities for integrating lake ecosystem modelling approaches

    Science.gov (United States)

    Mooij, Wolf M.; Trolle, Dennis; Jeppesen, Erik; Arhonditsis, George; Belolipetsky, Pavel V.; Chitamwebwa, Deonatus B.R.; Degermendzhy, Andrey G.; DeAngelis, Donald L.; Domis, Lisette N. De Senerpont; Downing, Andrea S.; Elliott, J. Alex; Ruberto, Carlos Ruberto; Gaedke, Ursula; Genova, Svetlana N.; Gulati, Ramesh D.; Hakanson, Lars; Hamilton, David P.; Hipsey, Matthew R.; Hoen, Jochem 't; Hulsmann, Stephan; Los, F. Hans; Makler-Pick, Vardit; Petzoldt, Thomas; Prokopkin, Igor G.; Rinke, Karsten; Schep, Sebastiaan A.; Tominaga, Koji; Van Dam, Anne A.; Van Nes, Egbert H.; Wells, Scott A.; Janse, Jan H.

    2010-01-01

    A large number and wide variety of lake ecosystem models have been developed and published during the past four decades. We identify two challenges for making further progress in this field. One such challenge is to avoid developing more models largely following the concept of others ('reinventing the wheel'). The other challenge is to avoid focusing on only one type of model, while ignoring new and diverse approaches that have become available ('having tunnel vision'). In this paper, we aim at improving the awareness of existing models and knowledge of concurrent approaches in lake ecosystem modelling, without covering all possible model tools and avenues. First, we present a broad variety of modelling approaches. To illustrate these approaches, we give brief descriptions of rather arbitrarily selected sets of specific models. We deal with static models (steady state and regression models), complex dynamic models (CAEDYM, CE-QUAL-W2, Delft 3D-ECO, LakeMab, LakeWeb, MyLake, PCLake, PROTECH, SALMO), structurally dynamic models and minimal dynamic models. We also discuss a group of approaches that could all be classified as individual based: super-individual models (Piscator, Charisma), physiologically structured models, stage-structured models and trait-based models. We briefly mention genetic algorithms, neural networks, Kalman filters and fuzzy logic. Thereafter, we zoom in, as an in-depth example, on the multi-decadal development and application of the lake ecosystem model PCLake and related models (PCLake Metamodel, Lake Shira Model, IPH-TRIM3D-PCLake). In the discussion, we argue that while the historical development of each approach and model is understandable given its 'leading principle', there are many opportunities for combining approaches. We take the point of view that a single 'right' approach does not exist and should not be strived for. Instead, multiple modelling approaches, applied concurrently to a given problem, can help develop an integrative

  4. Object-based Landslide Mapping: Examples, Challenges and Opportunities

    Science.gov (United States)

    Hölbling, Daniel; Eisank, Clemens; Friedl, Barbara; Chang, Kang-Tsung; Tsai, Tsai-Tsung; Birkefeldt Møller Pedersen, Gro; Betts, Harley; Cigna, Francesca; Chiang, Shou-Hao; Aubrey Robson, Benjamin; Bianchini, Silvia; Füreder, Petra; Albrecht, Florian; Spiekermann, Raphael; Weinke, Elisabeth; Blaschke, Thomas; Phillips, Chris

    2016-04-01

    types of landslides. Unlike in these northern European countries, landslides in Taiwan can be effectively delineated based on spectral differences as the surrounding is most often densely vegetated. In this tropical/subtropical region the fast information provision after Typhoon events is important. This need can be addressed in OBIA by automatically calculating thresholds based on vegetation indices and using them for a first rough identification of areas affected by landslides. Moreover, the differentiation in landslide source and transportation area is of high relevance in Taiwan. Finally, an example from New Zealand, where landslide inventory mapping is important for estimating surface erosion, will demonstrate the performance of OBIA compared to visual expert interpretation and on-screen mapping. The associated challenges and opportunities related to case studies in each of these regions are discussed and reviewed. In doing so, open research issues in object-based landslide mapping based on EO data are identified and highlighted.

  5. 78 FR 33849 - Battery-Powered Medical Devices Workshop: Challenges and Opportunities; Public Workshop; Request...

    Science.gov (United States)

    2013-06-05

    ... No. FDA-2013-N-0580] Battery-Powered Medical Devices Workshop: Challenges and Opportunities; Public... entitled ``Battery-Powered Medical Devices Workshop: Challenges and Opportunities''. The purpose of this workshop is to create awareness of the challenges related to battery-powered medical devices and...

  6. Communication in Healthcare: Opportunities for information technology and concerns for patient safety

    NARCIS (Netherlands)

    H. Pirnejad (Habibollah)

    2008-01-01

    textabstractUnderstanding healthcare workflow is fundamental for design and implementation of information systems. Communication and information exchange between healthcare professionals plays a pivotal role in developing smooth workflow within and between healthcare organizations. The study in this

  7. Elderly and long-term care trends and policy in Taiwan: Challenges and opportunities for health care professionals

    Directory of Open Access Journals (Sweden)

    Hsiu-Hung Wang

    2012-09-01

    Full Text Available The purpose of this article is to address the trends and policy of elderly and long-term care in Taiwan. In response to the increasing demand of an aging society, healthcare professionals play crucial roles in elderly and long-term care and quality assurance of services. This article focuses on the current situation of elderly health care, demands of long-term care, long-term care policy in Taiwan, draft of the Long-term Care Services Act, and draft of the Long-term Care Insurance Act. After the 10-year long-term care project was proposed by the Taiwan government, the supply of health care services and demand for long-term care have created many challenges and opportunities for innovative health professional development. Challenges consist of low old dependency ratio caused by low birth rate, lack of elderly and long-term care related manpower, services and education reform related to long-term care for the future society, and interprofessional collaboration and team work of long-term care. Opportunities include expanding the roles and the career pathways of healthcare professionals, promoting the concepts of active aging and good quality of life, and developing industrial cooperation related to long-term care services. Under these circumstances, healthcare professonals are actively involved in practice, education and research of long-term care services that ensure elderly and disabled people can live a healthier and better life.

  8. Challenge or hindrance: Does job stress affect presenteeism among Chinese healthcare workers?

    Science.gov (United States)

    Yang, Tianan; Ma, Mingxu; Zhu, Mingjing; Liu, Yuanling; Chen, Qian; Zhang, Shiyang; Deng, Jianwei

    2017-12-19

    We examined the effects of challenge stress and hindrance stress on general health and presenteeism among Chinese healthcare workers. Structural equation modeling was used to evaluate data from a national hospital survey in China (n = 1392). Job stress, general health, and presenteeism were measured by the Perceived Ability to Work Scale, the 8-item Short-Form Health Survey, and the Challenge- and Hindrance-Related Self-reported Stress Scale. Challenge stress and hindrance stress were significantly positively correlated (β = 0.62, SE = 0.021; p presenteeism (β = -0.05, SE = 0.037; p presenteeism (β = 0.25, SE = 0.040; p presenteeism were partially mediated by health. Hospital managers should provide healthcare workers with an appropriate level of challenge, but employee health is the most important consideration. Further efforts targeting job stress and health of junior healthcare workers are required.

  9. Mapping opportunities and challenges for rewilding in Europe

    Science.gov (United States)

    Ceaușu, Silvia; Hofmann, Max; Navarro, Laetitia M; Carver, Steve; Verburg, Peter H; Pereira, Henrique M

    2015-01-01

    Farmland abandonment takes place across the world due to socio-economic and ecological drivers. In Europe agricultural and environmental policies aim to prevent abandonment and halt ecological succession. Ecological rewilding has been recently proposed as an alternative strategy. We developed a framework to assess opportunities for rewilding across different dimensions of wilderness in Europe. We mapped artificial light, human accessibility based on transport infrastructure, proportion of harvested primary productivity (i.e., ecosystem productivity appropriated by humans through agriculture or forestry), and deviation from potential natural vegetation in areas projected to be abandoned by 2040. At the continental level, the levels of artificial light were low and the deviation from potential natural vegetation was high in areas of abandonment. The relative importance of wilderness metrics differed regionally and was strongly connected to local environmental and socio-economic contexts. Large areas of projected abandonment were often located in or around Natura 2000 sites. Based on these results, we argue that management should be tailored to restore the aspects of wilderness that are lacking in each region. There are many remaining challenges regarding biodiversity in Europe, but megafauna species are already recovering. To further potentiate large-scale rewilding, Natura 2000 management would need to incorporate rewilding approaches. Our framework can be applied to assessing rewilding opportunities and challenges in other world regions, and our results could guide redirection of subsidies to manage social-ecological systems. Mapeo de Oportunidades y Retos para el Retorno de la Vida Silvestre Resumen El abandono de tierras agrícolas ocurre en todo el mundo debido a factores socio-económicos y ecológicos. En Europa, las políticas ambientales y agrícolas tienen el objetivo de prevenir el abandono y frenar la sucesión ecológica. La reintroducción o el retorno

  10. Purchasing health care in China: experiences, opportunities and challenges.

    Science.gov (United States)

    Yip, Winnie; Hanson, Kara

    2009-01-01

    Purchasing has been promoted as a key policy instrument to improve health system performance. Despite its widespread adoption, there is little empirical evidence on how it works, the challenges surrounding its implementation, its impact, and the preconditions for it to function effectively, particularly in low- and middle-income settings. The objective of this chapter is to analyze critically the extent to which purchasing could be, and has been used strategically in China and to identify modifications that are needed for purchasing to be effective in assuring that the government's new funding for health care will result in efficient and effective health services. We present a conceptual framework for purchasing, which identifies three critical principal-agent relationships in purchasing. We draw on evidence from secondary data, results of other research studies, interviews, and the impact evaluation of a social experiment in rural China that explicitly used purchasing to improve quality and efficiency. This information is used to examine purchasing relationships in urban social health insurance (SHI), the rural medical insurance scheme, and purchasing of public health services. To date, use of strategic purchasing is limited in China. Both the urban and the rural health insurance schemes act as passive third-party payers, failing to take advantage of the opportunities to strengthen incentives to improve quality and efficiency. This may be because as government agencies, the extent to which the Ministries of Health and Labor and Social Security can act independently from provider interests, or act in the best interest of the population, is unclear. Other important challenges include ensuring adequate representation of the population's views and preferences and making better use of the leverage provided by purchasing to create appropriate provider incentives, through better integration of financing and improved coordination among purchasers. In designing purchasing

  11. Rebasing the Medicare Payment for Dialysis: Rationale, Challenges, and Opportunities

    Science.gov (United States)

    Johnson, Doug

    2014-01-01

    After Medicare’s implementation of the bundled payment for dialysis in 2011, there has been a predictable decrease in the use of intravenous drugs included in the bundle. The change in use of erythropoiesis-stimulating agents, which decreased by 37% between 2007, when its allowance in the bundle was calculated, and 2012, was because of both changes in the Food and Drug Administration labeling for erythropoiesis-stimulating agents in 2011 and cost-containment efforts at the facility level. Legislation in 2012 required Medicare to decrease (rebase) the bundled payment for dialysis in 2014 to reflect this decrease in intravenous drug use, which amounted to a cut of 12% or $30 per treatment. Medicare subsequently decided to phase in this decrease in payment over several years to offset the increase in dialysis payment that would otherwise have occurred with inflation. A 3% reduction from the rebasing would offset an approximately 3% increase in the market basket that determines a facility’s costs for 2014 and 2015. Legislation in March of 2014 provides that the rebasing will result in a 1.25% decrease in the market basket adjustment in 2016 and 2017 and a 1% decrease in the market basket adjustment in 2018 for an aggregate rebasing of 9.5% spread over 5 years. Adjusting to this payment decrease in inflation-adjusted dollars will be challenging for many dialysis providers in an industry that operates at an average 3%–4% margin. Closure of facilities, decreases in services, and increased consolidation of the industry are possible scenarios. Newer models of reimbursement, such as ESRD seamless care organizations, offer dialysis providers the opportunity to align incentives between themselves, nephrologists, hospitals, and other health care providers, potentially improving outcomes and saving money, which will be shared between Medicare and the participating providers. PMID:25189926

  12. Measuring Snow Precipitation in New Zealand- Challenges and Opportunities.

    Science.gov (United States)

    Renwick, J. A.; Zammit, C.

    2015-12-01

    Monitoring plays a pivotal role in determining sustainable strategy for efficient overall management of the water resource. Though periodic monitoring provides some information, only long-term monitoring can provide data sufficient in quantity and quality to determine trends and develop predictive models. These can support informed decisions about sustainable and efficient use of water resources in New Zealand. However the development of such strategies is underpinned by our understanding and our ability to measure all inputs in headwaters catchments, where most of the precipitation is falling. Historically due to the harsh environment New Zealand has had little to no formal high elevation monitoring stations for all climate and snow related parameters outside of ski field climate and snow stations. This leads to sparse and incomplete archived datasets. Due to the importance of these catchments to the New Zealand economy (eg irrigation, hydro-electricity generation, tourism) NIWA has developed a climate-snow and ice monitoring network (SIN) since 2006. This network extends existing monitoring by electricity generator and ski stations and it is used by a number of stakeholders. In 2014 the network comprises 13 stations located at elevation above 700masl. As part of the WMO Solid Precipitation Intercomparison Experiment (SPICE), NIWA is carrying out an intercomparison of precipitation data over the period 2013-2015 at Mueller Hut. The site was commissioned on 11 July 2013, set up on the 17th September 2013 and comprises two Geonor weighing bucket raingauges, one shielded and the other un-shielded, in association with a conventional tipping bucket raingauge and conventional climate and snow measurements (temperature, wind, solar radiation, relative humidity, snow depth and snow pillow). The presentation aims to outline the state of the current monitoring network in New Zealand, as well as the challenge and opportunities for measurement of precipitation in alpine

  13. Opportunities and challenges for collaborative funding with industry

    Science.gov (United States)

    Thompson, J. F.

    2014-12-01

    The discovery and extraction of natural resources represents major challenges on both technical and socio-political fronts. Societal demand for commodities continues to increase as population, infrastructure, energy demands and standards of living increase. In parallel, society expects more efficient, cleaner and more sustainable practices. There are therefore multiple incentives for industry to invest in research and innovation to meet these fundamental goals. Natural resource companies fund research internally and externally but the focus, approach and level of funding varies considerably among sectors, companies and disciplines. The wide variety of philosophies creates difficulties for those who seek to work with industry. Most funding arrangement are built through extensive engagement, opportunities to leverage funds particularly in higher risk or less well defined areas (e.g., geoscience), and the attraction of meeting potential new high quality employees. Barriers to funding include unrealistic perceptions of confidentiality issues in industry, bureaucracy and unrealistic IP constraints in academia, and onerous overhead charges by universities that vastly exceed those charged by consulting and contract researchers. Academics and students can benefit immensely from productive research arrangements with industry, but understanding realistic expectations on both sides is critical. Although funding from industry may introduce constraints, some companies are willing to take a virtual hands-off approach in support of quality science. Selecting the appropriate researchers and methodology is important; it takes time for students to become effective and some problems are simply not suited to graduate research, or even academia. Some Governments play an enormous role in facilitating collaborative research with industry while others struggle to differentiate programs that encourage investment from those that unfairly subsidize industry. The traditional Government role

  14. International ESCO business opportunities and challenges: a Japanese case study

    Energy Technology Data Exchange (ETDEWEB)

    Vine, E. [Lawrence Berkeley National Lab., CA (United States). Environmental Energy Technologies Div.; Murakoshi, C. [Jyukankyo Research Inst., Tokyo (Japan)

    1997-10-01

    Recently, US energy service companies (ESCOs) have begun to actively explore markets outside the US. Despite the needs of many countries for ESCO involvement, ESCOs face many challenges (i.e., marketing, financial, institutional, political and cultural barriers). Consequently, most of these firms pursue international project opportunities very selectively due to the costs and risks associated with project development. Despite these barriers, some ESCOs view international work as a strategic expansion of their business, assuming that there will be adequate business in the future to repay them for their initial investment. In this paper, the authors present the findings from a recently completed study on the proposed development of an ESCO industry in Japan. The study was based on four sources of information: (1) a review of the published and unpublished literature on ESCOs; (2) interviews with 26 ESCOs in the US, the US Department of Energy, and the National Association of Energy Service Companies (NAESCO); (3) ESCO presentations at the October 1996 NAESCO meeting; and (4) informal discussions with ESCO experts in the US. They believe that the lessons learned in this study can be transferred or applied to other countries interested in developing an ESCO industry. While energy prices have remained relatively stable over the last several years in Japan and energy capacity is not perceived as a near-term problem, other ``market drivers`` necessary for the emergence of a successful and vibrant ESCO industry exist in Japan. Despite the presence of these market drivers, significant barriers to the successful development of an ESCO industry exist in Japan.

  15. Local challenges and opportunities for language and literacy researchers and educators

    Directory of Open Access Journals (Sweden)

    Landis David

    2017-01-01

    Full Text Available This paper presents a three dimensional array of contemporary challenges and opportunities for language and literacy researchers and educators. The challenges and opportunities result from dynamic human migration, widespread use of mobile digital technology, and the development of the internet. Recent publications are discussed that exemplify the challenges and opportunities. Particular attention is given to spaces as local contexts for language and literacy learning. Focusing discussion upon the challenges and opportunities is one way of building knowledge about how people use modes of communication to develop, use, and learn language and literacies.

  16. Classroom ICT integration in Tanzania: Opportunities and challenges from the perspectives of TPACK and SAMR models

    National Research Council Canada - National Science Library

    Patrick Kihoza; Irina Zlotnikova; Joseph Bada; Khamisi Kalegele

    2016-01-01

    ...) into their future teaching and learning practices. This study assessed classroom ICTs integration opportunities and the challenges in relation to Technological Pedagogical and Content Knowledge (TPACK) and SAMR...

  17. Call for shared decision making in China: Challenges and opportunities.

    Science.gov (United States)

    Yao, Mi; Finnikin, Samuel; Cheng, K K

    2017-06-01

    China's healthcare system has undergone extensive changes over recent years and the most recent reforms are designed to shift the emphasis away from hospital based services towards a more primary care based system. There is an increasing recognition that shared decision making needs to play a central role in the delivery of healthcare in China, but there are several significant barriers to overcome before this aspiration becomes a reality. Doctor-patient relationships in China are poor, consultations are often brief transactions and levels of trust are low. Implementing a shared decision making process developed in the Western World may be hampered by cultural differences, although this remains an under-researched area. There is, however, a suggestion that the academic community is starting to take an interest in encouraging shared decision making in practice and indications that the Chinese public may be willing to consider this new approach to healthcare. Copyright © 2017. Published by Elsevier GmbH.

  18. New Teaching Opportunities and Challenges for US Geography.

    Science.gov (United States)

    Harper, Robert A.

    1985-01-01

    Today two opportunities are open to geography educators. First they must respond to the new opportunity to return geography to a place in the preparation of business students. Second, geography educators must take advantage of the current interest in international understanding and global education. New courses and textbooks are needed. (RM)

  19. Reflections on the Opportunities and Challenges of Disaster Response

    Science.gov (United States)

    Juntunen, Cindy L.

    2011-01-01

    This reaction article applauds the authors of the Major Contribution for their thoughtful and thorough consideration of the myriad issues that accompany disaster mental health work. The reaction highlights three themes that emerged in the articles of the contribution: opportunities for collaboration, opportunities for the application of social…

  20. Challenges and opportunities for minority owned trucking firms under affirmative actions : a case study.

    Science.gov (United States)

    2012-01-01

    Despite the steady growth and the introduction of "set-aside" programs/Affirmative Actions, minority owned firms often faced stiff business challenges. These challenges include a lack of business networking opportunities, limited financial resources,...

  1. CARDIOLOGY CLINICAL TRIAL PARTICIPATION IN COMMUNITY-BASED HEALTHCARE SYSTEMS: OBSTACLES AND OPPORTUNITIES

    Science.gov (United States)

    Somkin, Carol P.; Altschuler, Andrea; Ackerson, Lynn; Tolsma, Dennis; Rolnick, Sharon J.; Yood, Robert; Weaver, W. Douglas; Von Worley, Ann; Hornbrook, Mark; Magid, David J.; Go, Alan S.

    2008-01-01

    Background The objective of our study was to examine cardiologists’ and organizational leaders’ interest in clinical trial participation and perceived barriers and facilitators to participation within ten diverse non-profit healthcare delivery systems. Trials play a pivotal role in advancing knowledge about the safety and efficacy of cardiovascular interventions and tests. Although cardiovascular trials successfully enroll patients, recruitment challenges persist. Community-based health systems could be an important source of participants and investigators, but little is known about community cardiologists’ experiences with trials. Methods We interviewed 25 cardiology and administrative leaders and mailed questionnaires to all 280 cardiologists at 10 U.S. healthcare organizations. Results The survey received a 73% response rate. While 60% of respondents had not participated in any trials in the past year, nearly 75% wanted greater participation. Cardiologists reported positive attitudes toward trial participation; more than half agreed that trials were their first choice of therapy for patients, if available. Almost all leaders described their organizations as valuing research but not necessarily trials. Major barriers to participation were lack of physician time and insufficient skilled research nurses. Conclusions Cardiologists have considerable interest in trial participation. Major obstacles to increased participation are lack of time and effective infrastructure to support trials. These results suggest that community-based health systems are a rich source for cardiovascular research but additional funding and infrastructure are needed to leverage this resource. PMID:18397842

  2. Challenges of the New Zealand healthcare disaster preparedness prior to the Canterbury earthquakes: a qualitative analysis.

    Science.gov (United States)

    Al-Shaqsi, Sultan; Gauld, Robin; Lovell, Sarah; McBride, David; Al-Kashmiri, Ammar; Al-Harthy, Abdullah

    2013-03-15

    Disasters are a growing global phenomenon. New Zealand has suffered several major disasters in recent times. The state of healthcare disaster preparedness in New Zealand prior to the Canterbury earthquakes is not well documented. To investigate the challenges of the New Zealand healthcare disaster preparedness prior to the Canterbury earthquakes. Semi-structured interviews with emergency planners in all the District Health Boards (DHBs) in New Zealand in the period between January and March 2010. The interview protocol revolved around the domains of emergency planning adopted by the World Health Organization. Seventeen interviews were conducted. The main themes included disinterest of clinical personnel in emergency planning, the need for communication backup, the integration of private services in disaster preparedness, the value of volunteers, the requirement for regular disaster training, and the need to enhance surge capability of the New Zealand healthcare system to respond to disasters. Prior to the Canterbury earthquakes, healthcare disaster preparedness faced multiple challenges. Despite these challenges, New Zealand's healthcare response was adequate. Future preparedness has to consider the lessons learnt from the 2011 earthquakes to improve healthcare disaster planning in New Zealand.

  3. Patient-centered outcomes research in emergency care: opportunities, challenges and future directions

    Science.gov (United States)

    Rising, Kristin L.; Carr, Brendan G.; Hess, Erik P.; Meisel, Zachary F.; Ranney, Megan L.; Vogel, Jody A.

    2017-01-01

    The Patient-Centered Outcomes Research Institute (PCORI) was established by Congress in 2010 to promote the conduct of research that could better inform patients in making decisions that reflect their desired health outcomes. PCORI has established five national priorities for research around which specific funding opportunities are issued: 1) Assessment of Prevention, Diagnosis and Treatment Options, 2) Improving Healthcare Systems, 3) Communication and Dissemination Research, 4) Addressing Disparities, and 5) Improving Methods for Conducting Patient-Centered Outcomes Research. To date, implementation of patient-centered research in the emergency care setting has been limited, in part because of perceived challenges in meeting PCORI priorities such as the need to focus on a specific disease state or to have planned follow up. We suggest that these same factors that have been seen as challenges to performing patient-centered research within the emergency setting are also potential strengths to be leveraged to conduct PCORI research. This paper explores factors unique to patient-centered emergency care research and highlights specific areas of potential alignment within each PCORI priority. PMID:26919027

  4. Open Innovation Challenge in Healthcare. Role for Education.

    Science.gov (United States)

    Dimitriu, Rodica; Lungeanu, Diana; Mãnescu, Cristina; Pantazi, Mirela; Mihalas, George I

    2015-01-01

    The vision of this paper is that collaboration creates new openings for engagement of non-commercial actors, such as universities, in innovation networks on the one hand, while opening up for collaborative innovation, and getting valuable real life anchors on the other hand, all these underpinned by greater connectivity and globalization. We present our approach in re-designing the courses on medical informatics and data processing to meet these challenges by employing public Internet services and media facilitation.

  5. The Evolving Academic Health Center: Challenges and Opportunities for Psychiatry

    Science.gov (United States)

    Mirin, Steven; Summergrad, Paul

    2011-01-01

    Objective: Regardless of the outcome of current efforts at healthcare reform, the resources that academic health centers need--to provide care for increasingly complex patient populations, support clinical innovation, grow the clinical enterprise, and carry out their research and teaching missions--are in jeopardy. This article examines the value…

  6. Digital Technology and Mental Health Interventions: Opportunities and Challenges

    Directory of Open Access Journals (Sweden)

    Aguilera, Adrian

    2015-02-01

    Full Text Available The growth of the Internet, mobile phones, social media and other digital technologies has changed our world in many ways. It has provided individuals with information that was previously only available to a select few. An example of the reach of technology is data that as of October 2012, there are over 6 billion phones worldwide (BBC, 2012. The availability of data in real time has presented hopes of intervening more efficiently and managing health problems by leveraging limited human resources. It also has an impact in changing the roles of providers and patients and in legal and ethical issues including privacy in digital health interactions. This paper will discuss why digital technology has received recent attention in the area of mental health, present some applications of technology for mental health to date, explore the challenges to full implementation in clinical settings, and present future opportunities for digital technologies.El crecimiento del Internet, los teléfonos móviles, las redes sociales y otras tecnologías digitales ha cambiado nuestro mundo de muchas maneras. Ha proporcionado a las personas con la información que antes sólo estaba disponible para un grupo selecto, por ejemplo a partir de octubre de 2012. Un ejemplo del alcance de la tecnología son los datos que dicen que hay más de 6 millones de teléfonos en todo el mundo (BBC, 2012. La disponibilidad de los datos en tiempo real a presentado la esperanza de intervenir de manera más eficiente y manejar los problemas de salud los recursos humanos limitados. También tiene un impacto en el cambio de los roles de los proveedores y los pacientes y en aspectos legales y éticos, incluyendo la privacidad en las interacciones de salud digital. Este artículo discutirá unas razones por cual la tecnología digital ha recibido atención recientemente en el área de salud mental, presentará algunas aplicaciones de la tecnología para mejorar la salud mental hasta la fecha

  7. Valorisation of post-sorption materials: Opportunities, strategies, and challenges.

    Science.gov (United States)

    Harikishore Kumar Reddy, D; Vijayaraghavan, K; Kim, Jeong Ae; Yun, Yeoung-Sang

    2017-04-01

    Adsorption is a facile, economic, eco-friendly and low-energy requiring technology that aims to separate diverse compounds (ions and molecules) from one phase to another using a wide variety of adsorbent materials. To date, this technology has been used most often for removal/recovery of pollutants from aqueous solutions; however, emerging post-sorption technologies are now enabling the manufacture of value-added key adsorption products that can subsequently be used for (i) fertilizers, (ii) catalysis, (iii) carbonaceous metal nanoparticle synthesis, (iv) feed additives, and (v) biologically active compounds. These new strategies ensure the sustainable valorisation of post-sorption materials as an economically viable alternative to the engineering of other green chemical products because of the ecological affability, biocompatibility, and widespread accessibility of post-sorption materials. Fertilizers and feed additives manufactured using sorption technology contain elements such as N, P, Cu, Mn, and Zn, which improve soil fertility and provide essential nutrients to animals and humans. This green and effective approach to managing post-sorption materials is an important step in reaching the global goals of sustainability and healthy human nutrition. Post-sorbents have also been utilized for the harvesting of metal nanoparticles via modern catalytic pyrolysis techniques. The resulting materials exhibited a high surface area (>1000m(2)/g) and are further used as catalysts and adsorbents. Together with the above possibilities, energy production from post-sorbents is under exploration. Many of the vital 3E (energy, environment, and economy) problems can be addressed using post-sorption materials. In this review, we summarize a new generation of applications of post-adsorbents as value-added green chemical products. At the end of each section, scientific challenges, further opportunities, and issues related to toxicity are discussed. We believe this critical

  8. Healthcare

    Science.gov (United States)

    Carnevale, Anthony P.; Smith, Nicole; Gulish, Artem; Beach, Bennett H.

    2012-01-01

    This report, provides detailed analyses and projections of occupations in healthcare fields, and wages earned. In addition, the important skills and work values associated with workers in those fields of healthcare are discussed. Finally, the authors analyze the implications of research findings for the racial, ethnic, and class diversity of the…

  9. Trends and Challenges in Smart Healthcare Research: A Journey from Data to Wisdom

    Energy Technology Data Exchange (ETDEWEB)

    Solanas, Agusti; Fran, Casino; Batista, Edgar; Rallo Moya, Roberto J.

    2017-10-12

    Smart Healthcare is a relatively new context-aware healthcare paradigm influenced by several fields of knowledge, namely medical informatics, communications and electronics, bioengineering, ethics and so on. Thus, many challenging problems are related to smart healthcare but in many cases they are explored individually in their respective fields and, as a result, they are not always known by the smart healthcare research community working in more specific domains. The aim of this article is to identify some of the most relevant trends and research lines that are going to affect the smart healthcare field in the years to come. To do so, the article considers a systematic approach that classifies the identified research trends and problems according to their appearance within the data life cycle, this is, from the data gathering in the physical layer (lowest level) until their final use in the application layer (highest level). By identifying and classifying those research trends and challenges, we help to pose questions that the smart healthcare community will need to address. Consequently, we set a common ground to explore important problems in the field, which will have significant impact in the years to come.

  10. A culturally diverse staff population: challenges and opportunities for nurses.

    Science.gov (United States)

    Mattson, Susan

    2009-01-01

    The United States is seeing an increase in ethnic and cultural diversity that is reflected (albeit to a smaller extent) in the nursing workforce. There are also more nurses who are foreign-born and educated. These nurses bring elements of their ethnic culture to the healthcare setting, including that of the "healthcare provider" culture of their home country. Often these values conflict with, or at least differ from, many American values seen in the workplace, such as autonomy of patients, an individualistic approach to relationships, peer relationships rather than hierarchical ones, democracy as an ideal norm, optimal health is ideal, and an emphasis on time/schedules and use of technology. A major cultural difference in the work setting has to do with the meaning of "work" itself, which can vary among cultural groups; in addition, some cultures are viewed as more "collective" in nature than the American ones, which are considered "individualistic." In particular, foreign-born and educated nurses from different healthcare systems bring with them values of the political system in which they work, the concept of a socialized system of medicine, language and accent differences, different concepts of nursing duties, and varying psychosocial skills.

  11. Violence in the United States: Status, Challenges, and Opportunities.

    Science.gov (United States)

    Sumner, Steven A; Mercy, James A; Dahlberg, Linda L; Hillis, Susan D; Klevens, Joanne; Houry, Debra

    2015-08-04

    Interpersonal violence, which includes child abuse and neglect, youth violence, intimate partner violence, sexual violence, and elder abuse, affects millions of US residents each year. However, surveillance systems, programs, and policies to address violence often lack broad, cross-sector collaboration, and there is limited awareness of effective strategies to prevent violence. To describe the burden of interpersonal violence in the United States, explore challenges to violence prevention efforts and to identify prevention opportunities. We reviewed data from health and law enforcement surveillance systems including the National Vital Statistics System, the Federal Bureau of Investigation's Uniform Crime Reports, the US Justice Department's National Crime Victimization Survey, the National Survey of Children's Exposure to Violence, the National Child Abuse and Neglect Data System, the National Intimate Partner and Sexual Violence Survey, the Youth Risk Behavior Surveillance System, and the National Electronic Injury Surveillance System-All Injury Program. Homicide rates have decreased from a peak of 10.7 per 100,000 persons in 1980 to 5.1 per 100,000 in 2013. Aggravated assault rates have decreased from a peak of 442 per 100,000 in 1992 to 242 per 100,000 in 2012. Nevertheless, annually, there are more than 16,000 homicides and 1.6 million nonfatal assault injuries requiring treatment in emergency departments. More than 12 million adults experience intimate partner violence annually and more than 10 million children younger than 18 years experience some form of maltreatment from a caregiver, ranging from neglect to sexual abuse, but only a small percentage of these violent incidents are reported to law enforcement, health care clinicians, or child protective agencies. Moreover, exposure to violence increases vulnerability to a broad range of mental and physical health problems over the life course; for example, meta-analyses indicate that exposure to physical abuse

  12. Immunizations challenge healthcare personnel and affects immunization rates.

    Science.gov (United States)

    Strohfus, Pamela K; Kim, Susan C; Palma, Sara; Duke, Russell A; Remington, Richard; Roberts, Caleb

    2017-02-01

    This study measured 1. medical office immunization rates and 2. health care personnel competency in managing vaccine practices before and after evidence-based immunization education was provided. This descriptive study compared 32 family medicine and pediatric offices and 178 medical assistants, licensed practical nurses, registered nurses, nurse practitioners, and physicians in knowledge-based testing pre-education, post-education, and 12-months post-education. Immunization rates were assessed before and 18-months post-education. Immunization rates increased 10.3% - 18months post-education; knowledge increased 7.8% - 12months post-education. Family medicine offices, licensed practical nurses, and medical assistants showed significant knowledge deficits before and 12-months post-education. All demographic groups scored less in storage/handling 12-months post-education. This study is one of the first studies to identify competency challenges in effective immunization delivery among medical assistants, licensed practical nurses, and family medicine offices. Formal and continuous education in immunization administration and storage/handling is recommended among these select groups. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Challenges and opportunities for migration towards 10GPON

    Science.gov (United States)

    Mickelsson, Hans; In De Betou, Einar; Skubic, Björn; Dahlfort, Stefan

    2009-11-01

    Different technical challenges for migration from GPON to 10GPON are discussed and also put into context of standardization. The challenges include how to handle an increased upstream capacity through use of burst-mode receivers and DBA algorithms, extension of reach and wavelength planning for future proofing the fiber infrastructure. Finally the roadmap towards 10GPON standardization is discussed.

  14. Challenges and opportunities in supporting sustainable agriculture and food security

    Science.gov (United States)

    The 2014 IUPAC International Congress of Pesticide Chemistry (San Francisco, August, 2014) included a symposium on “Challenges Associated with Global Adoption of Agricultural Biotechnology” to review current obstacles in promoting GM crops. Challenges identified by symposium presenters included i) ...

  15. The Google Online Marketing Challenge and Research Opportunities

    Science.gov (United States)

    Neale, Larry; Treiblmaier, Horst; Henderson, Vani; Hunter, Lee; Hudson, Karen; Murphy, Jamie

    2009-01-01

    The Google Online Marketing Challenge is an ongoing collaboration between Google and academics, to give students experiential learning. The Challenge gives student teams US$200 in AdWords, Google's flagship advertising product, to develop online marketing campaigns for actual businesses. The end result is an engaging in-class exercise that…

  16. Online Learning: Addressing Challenges and Seizing Opportunities. Hawaii

    Science.gov (United States)

    Alliance for Excellent Education, 2010

    2010-01-01

    America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

  17. Transforming Teaching Challenges into Learning Opportunities: Interdisciplinary Reflective Collaboration

    Science.gov (United States)

    Callaghan, Ronel

    2015-01-01

    Teaching in higher education poses unique sets of challenges, especially for academics in the engineering, built sciences and information science education disciplines. This article focuses on how reflective collaboration can support academics in their quest to find unique solutions to challenges in different academic contexts. A reflective…

  18. WE-AB-213-03: Challenges and Opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Borras, C.

    2015-06-15

    recruitment of professionals with incomplete education. In most LA countries only one MP responsible for each Center is currently mandated. Currently there is a large disparity among MP training programs and there is significant debate about the standards of MP graduate education in many LA countries. There are no commonly recognized academic programs, not enough clinical training sites and clinical training is not typically considered as part of the MP work. Economic pressures and high workloads also impede the creation of more training centers. The increasing need of qualified MPs require establishing a coordinated system of national Education & Training Centers (ETC), to meet the international standards of education and training in Medical Physics. This shortfall calls for support of organizations such as the IOMP, AAPM, ALFIM, IAEA, etc. Examples from various LA countries, as well as some proposed solutions, will be presented. In particular, we will discuss the resources that the AAPM and its members can offer to support regional programs. The ‘Medical Imaging’ physicist in the emerging world: Challenges and opportunities - Caridad Borrás (WGNIMP Chair) While the role of radiation therapy physicists in the emerging world is reasonably well established, the role of medical imaging physicists is not. The only perceived needs in radiology departments are equipment quality control and radiation protection, tasks that can be done by a technologist or a service engineer. To change the situation, the International Basic Safety Standard, which is adopted/adapted world-wide as national radiation protection regulations, states: “For diagnostic radiological procedures and image guided interventional procedures, the requirements of these Standards for medical imaging, calibration, dosimetry and quality assurance, including the acceptance and commissioning of medical radiological equipment, are fulfilled by or under the oversight of, or with the documented advice of a medical

  19. Bringing Video Communication to the Community: Opportunities and Challenges

    NARCIS (Netherlands)

    I. Kegel; P.S. Cesar Garcia (Pablo Santiago); M. Ursu; R. Kaiser; A.J. Jansen (Jack)

    2013-01-01

    htmlabstractThe rise of online social networks, the wide availability of video communication technology and the deployment of high-speed broadband networks together provide the opportunity for video to become a medium for mass social communication among communities. However, current solutions

  20. Opportunities and Challenges for Initial Implementation of Solutions Journalism Coursework

    Science.gov (United States)

    Thier, Kathryn

    2016-01-01

    As journalism schools continue to respond to industry disruption, some are adding curricula about practices that reframe traditional journalism. In this article, I examined experiences of some of the first university instructors of solutions journalism--critical reporting on responses to social problems--to explore the opportunities and challenges…

  1. The New WTO Telecom Agreement: Opportunities and Challenges.

    Science.gov (United States)

    Sisson, Peter

    1997-01-01

    The telecommunication agreement reached by the World Trade Organization (WTO) in 1997 will accelerate the global trend toward increased market access, competition, and deregulation. Examines opportunities for marketing and operations, dispute resolution and enforcement, profitability, and the exclusion of Russia and China. Includes the WTO…

  2. OBOR opportunities and challenges for the Dutch Agribusiness Sector

    OpenAIRE

    Zhang, Xiaoyong

    2016-01-01

    The Netherlands is the second largest exporter of Agriproducts in the world.However, its export volume to China is insignificant. The ‘One Belt One Road’initiative (OBOR) provides a great opportunity to increase the volume. But thiswill not be achieved easily. It requires a vision and collective action.

  3. OBOR opportunities and challenges for the Dutch Agribusiness Sector

    NARCIS (Netherlands)

    Zhang, Xiaoyong

    2016-01-01

    The Netherlands is the second largest exporter of Agriproducts in the world.
    However, its export volume to China is insignificant. The ‘One Belt One Road’
    initiative (OBOR) provides a great opportunity to increase the volume. But this
    will not be achieved easily. It requires a vision and

  4. Opportunities and Challenges for Women Engineers in Industry.

    Science.gov (United States)

    O'Brien, J. Edwin

    There are real opportunities for women in engineering, reflecting demands created by the dramatic rate of change in society. Increasingly complex technology, fast response time, the demands of production and managerial positions, increased levels of education and sophistication of employees, shifts in motivational needs, and new organizational…

  5. Key Challenges and Potential Urban Modelling Opportunities in ...

    African Journals Online (AJOL)

    Urban growth and land use change models, supported by Geographic Information Systems (GIS) software and increased digital data availability, have the ... and opportunities for modelling urban spatial change, with specific reference to the Gauteng City-Region – the heartland of the South African economy and the ...

  6. FUTURE CHALLENGES AND OPPORTUNITIES IN ACADEMIC PUBLISHING 1

    National Research Council Canada - National Science Library

    Kyle Siler

    2017-01-01

    .... The current publishing system involves challenges with cost, where many universities are forced to cancel journal subscriptions for economic reasons, as well as access, as scholars and the public...

  7. Security in Visible Light Communication: Novel Challenges and Opportunities

    Directory of Open Access Journals (Sweden)

    Christian ROHNER

    2015-09-01

    Full Text Available As LED lighting becomes increasingly ubiquitous, Visible Light Communication is attracting the interest of academia and industry as a complement to RF as the physical layer for the Internet of Things. Aside from its much greater spectral availability compared to RF, visible light has several attractive properties that may promote its uptake: its lack of health risks, its opportunities for spatial reuse, its relative immunity to multipath fading, its lack of electromagnetic interference, and its inherently secure nature: differently from RF, light does not penetrate through walls. In this paper, we outline the security implications of Visible Light Communication, review the existing contributions to this under-explored space, and survey the research opportunities that we envision for the near future.

  8. Opportunities and challenges within urban health and sustainable development

    DEFF Research Database (Denmark)

    Fisher, Jack E.; Andersen, Zorana J.; Loft, Steffen

    2017-01-01

    The United Nations’ Sustainable Development Goals mark aunique window of opportunity for both human and planetaryhealth. With rising life expectancy and rapidly expanding urbanpopulations exposed to pollution and sedentary lifestyles, thereis a greater focus on reducing the gap between life...... expectancyand number of healthy years lived, whilst limiting anthropogenicactivities contributing to pollution and climate change. Thus,urban development and policies, which can create win–winsituations for our planet and human health, falls into the realmand expertise of public health. However, some...

  9. The Continuing Evolution of Official Statistics: Some Challenges and Opportunities

    Directory of Open Access Journals (Sweden)

    MacFeely Steve

    2016-12-01

    Full Text Available As economies, societies, and environments change, official statistics evolve and develop to reflect those changes. In reaction to disruptive innovations arising from globalisation, technological advances, and cultural changes, the pace of change of official statistics will accelerate in the future. The motivation for change may also be more existential than that of the past as official statisticians consider the survival of their discipline. This article examines some of the emerging developments and questions whether they present threats or offer opportunities.

  10. The complexity of collaboration: Opportunities and challenges in contracted research

    Directory of Open Access Journals (Sweden)

    Marion Bowl

    2010-11-01

    Full Text Available This article explores some of the challenges of utilising collaborative research approaches when undertaking contracted research projects for government and non-government agencies in the adult and community education (ACE sector. To discuss these challenges, the article draws on three recent examples of research projects undertaken for ACE sector organisations in Aotearoa New Zealand. These challenges include managing relationships with the different parties to the research; dealing with conflicting expectations of funding agencies, commissioning organisations and practitioners; and ownership and dissemination of findings. We highlight the complexity of notions of collaboration and the importance of deliberate trust-building in establishing credibility. We also open up for discussion the thorny issues of who owns the right to disseminate research findings and how far should researchers’ and universities’ responsibilities extend to ensure that research findings are put in the public domain?

  11. Challenges and opportunities of open data in ecology.

    Science.gov (United States)

    Reichman, O J; Jones, Matthew B; Schildhauer, Mark P

    2011-02-11

    Ecology is a synthetic discipline benefiting from open access to data from the earth, life, and social sciences. Technological challenges exist, however, due to the dispersed and heterogeneous nature of these data. Standardization of methods and development of robust metadata can increase data access but are not sufficient. Reproducibility of analyses is also important, and executable workflows are addressing this issue by capturing data provenance. Sociological challenges, including inadequate rewards for sharing data, must also be resolved. The establishment of well-curated, federated data repositories will provide a means to preserve data while promoting attribution and acknowledgement of its use.

  12. Metabolomics: Challenges and Opportunities in Systems Biology Studies.

    Science.gov (United States)

    Casadei, Luca; Valerio, Mariacristina; Manetti, Cesare

    2018-01-01

    Metabolomics has the capability of providing predisposition, diagnostic, prognostic, and therapeutic biomarker profiles of individual patients, since a large number of metabolites can be measured in an unbiased manner from biological samples. In this setting, (1)H-Nuclear Magnetic Resonance (NMR) spectroscopy of biofluids such as plasma, urine, and fecal water offers the opportunity to identify patterns of biomarker changes that reflects the physiological or pathological status of an individual patient.In this chapter, we show as a metabolomics study can be used to diagnose a disease, classifying patients as healthy or as pathological taking into account individual variability.

  13. Borderland Spaces for Learning Partnership: Opportunities, Benefits and Challenges

    Science.gov (United States)

    Hill, Jennifer; Thomas, Greg; Diaz, Anita; Simm, David

    2016-01-01

    This paper uses case studies and secondary literature to critically examine how learning spaces inhabited by geographers might be used productively as borderland spaces for learning partnership. Borderland spaces are novel, challenging, permissive and liminal, destabilizing traditional power hierarchies. In these spaces, students gain confidence…

  14. Modeling fMRI Data: Challenges and Opportunities

    Science.gov (United States)

    Maydeu-Olivares, Alberto; Brown, Gregory

    2013-01-01

    We offer an introduction to the five papers that make up this special section. These papers deal with a range of the methodological challenges that face researchers analyzing fMRI data--the spatial, multilevel, and longitudinal nature of the data, the sources of noise, and so on. The papers all provide analyses of data collected by a multi-site…

  15. Dealing with bio- and ecological complexity: challenges and opportunities

    NARCIS (Netherlands)

    Carson, E.; Feng, D.D.; Pons, M.N.; Soncini-Sessa, R.; Straten, van G.

    2005-01-01

    The complexities of the dynamic processes and their control associated with biological and ecological systems offer many challenges for the control engineer. Over the past decades the application of dynamic modelling and control has aided understanding of their complexities. At the same time using

  16. Online communities: Challenges and opportunities for social network research

    NARCIS (Netherlands)

    Groenewegen, P.; Moser, C.; Brass, D.; Labianca, G.; Mehra, A.; Halgin, D; Borgatti, S

    2014-01-01

    Online communities form a challenging and still-evolving field for social network research. We highlight two themes that are at the core of social network literature: formative processes and structures, and discuss how these might be relevant in the context of online communities. Processes of tie

  17. Rethinking cancer: current challenges and opportunities in cancer research

    Directory of Open Access Journals (Sweden)

    Ross Cagan

    2017-04-01

    Full Text Available Cancer therapeutics currently have the lowest clinical trial success rate of all major diseases. Partly as a result of the paucity of successful anti-cancer drugs, cancer will soon be the leading cause of mortality in developed countries. As a disease embedded in the fundamentals of our biology, cancer presents difficult challenges that would benefit from uniting experts from a broad cross-section of related and unrelated fields. Combining extant approaches with novel ones could help in tackling this challenging health problem, enabling the development of therapeutics to stop disease progression and prolong patient lives. This goal provided the inspiration for a recent workshop titled ‘Rethinking Cancer’, which brought together a group of cancer scientists who work in the academic and pharmaceutical sectors of Europe, America and Asia. In this Editorial, we discuss the main themes emerging from the workshop, with the aim of providing a snapshot of key challenges faced by the cancer research community today. We also outline potential strategies for addressing some of these challenges, from understanding the basic evolution of cancer and improving its early detection to streamlining the thorny process of moving promising drug targets into clinical trials.

  18. Inclusive Education in Higher Education: Challenges and Opportunities

    Science.gov (United States)

    Moriña, Anabel

    2017-01-01

    Implementing the principles of inclusive education within higher education can be challenging. Inclusive education was originally developed for younger students, prior to its application within higher education. However, as more students with disabilities successfully complete their early schooling, the need to move towards inclusive practices…

  19. Rethinking cancer: current challenges and opportunities in cancer research

    Science.gov (United States)

    Cagan, Ross; Meyer, Pablo

    2017-01-01

    ABSTRACT Cancer therapeutics currently have the lowest clinical trial success rate of all major diseases. Partly as a result of the paucity of successful anti-cancer drugs, cancer will soon be the leading cause of mortality in developed countries. As a disease embedded in the fundamentals of our biology, cancer presents difficult challenges that would benefit from uniting experts from a broad cross-section of related and unrelated fields. Combining extant approaches with novel ones could help in tackling this challenging health problem, enabling the development of therapeutics to stop disease progression and prolong patient lives. This goal provided the inspiration for a recent workshop titled ‘Rethinking Cancer’, which brought together a group of cancer scientists who work in the academic and pharmaceutical sectors of Europe, America and Asia. In this Editorial, we discuss the main themes emerging from the workshop, with the aim of providing a snapshot of key challenges faced by the cancer research community today. We also outline potential strategies for addressing some of these challenges, from understanding the basic evolution of cancer and improving its early detection to streamlining the thorny process of moving promising drug targets into clinical trials. PMID:28381596

  20. Challenges and Opportunities Facing Technology Education in Taiwan

    Science.gov (United States)

    Lee, Lung-Sheng Steven

    2009-01-01

    The technology education in Taiwan is prescribed in the national curriculum and provided to all students in grades 1-12. However, it faces the following challenges: (1) Lack of worthy image, (2) Inadequate teachers in elementary schools, (3) Deficient teaching vitality in secondary schools, and (4) Diluted technology teacher education programs. In…

  1. Visualizing Decimal Multiplication with Area Models: Opportunities and Challenges

    Science.gov (United States)

    Rathouz, Margaret

    2011-01-01

    This article describes a pilot study in which pre-service elementary teachers (PSTs) used rectangular area models on base-10 grid paper to begin making sense of multiplication of decimal fractions. Although connections were made to multi-digit whole number multiplication and to the distributive property, the PSTs were challenged by interpreting…

  2. Dealing with bio- and ecological complexity, Challenges and Opportunities

    NARCIS (Netherlands)

    Carson, E.; Feng, D.D.; Pons, M.N.; Sconcini-Sessa, R.; Straten, van G.

    2006-01-01

    The complexities of the dynamic processes and their control associated with biological and ecological systems offer many challenges for the control engineer. Over the past decades the application of dynamic modelling and control has aided understanding of their complexities. At the same time using

  3. Challenges and opportunities for quality seed potato availability and ...

    African Journals Online (AJOL)

    ACSS

    varieties, poor management practices and lack of quality seed potatoes among other factors. This ... Key words: Quality seed potato, seed system and challenges ... chain. In Uganda, the potato formal seed system is not well developed, it operates through a semi-formal institutional arrangement for multiplication and.

  4. Functional Inkjet Printing on Textiles : Challenges and Opportunities

    NARCIS (Netherlands)

    Agrawal, P. (Pramod); Brinks, G.J. (Ger); Gooijer, H. (Henk)

    2012-01-01

    The main challenge for the Dutch and European textile and clothing sector is to make a paradigm shift from labour intensive industry to knowledge based industry. This shift is essential for gaining a competitive edge and to develop innovative products and eco-friendly processes. A promising

  5. Using Twitter™ to drive research impact: A discussion of strategies, opportunities and challenges.

    Science.gov (United States)

    Schnitzler, Katy; Davies, Nigel; Ross, Fiona; Harris, Ruth

    2016-07-01

    Researchers have always recognised the importance of disseminating the findings of their work, however, recently the need to proactively plan and drive the impact of those findings on the wider society has become a necessity. Firstly, this is because funders require evidence of return from investment and secondly and crucially because national research assessments are becoming powerful determinants of future funding. In research studies associated with nursing, impact needs to be demonstrated by showing the effect on a range of stakeholders including service users, patients, carers, the nursing workforce and commissioners. Engaging these groups is a well-known challenge influenced by lack of access to academic journals, lack of time to read long complex research papers and lack of opportunities to interact directly with the researchers. This needs to be addressed urgently to enable nursing research to increase the impact that it has on health delivery and the work of clinical practitioners. Social media is potentially a novel way of enabling research teams to both communicate about research as studies progress and to disseminate findings and research funders are increasingly using it to publicise information about research programmes and studies they fund. A search of the healthcare literature reveals that advice and guidance on the use of social media for research studies is not well understood or exploited by the research community. This paper, therefore, explores how using social networking platforms, notably Twitter™ offers potential new ways for communicating research findings, accessing diverse and traditionally hard-to-reach audiences, knowledge exchange at an exponential rate, and enabling new means of capturing and demonstrating research impact. The paper discusses approaches to initiate the setup of social networking platforms in research projects and considers the practical challenges of using Twitter™ in nursing and healthcare research. The

  6. Becoming the Citizen Scientist: Opportunities and Challenges in Science Policy

    Science.gov (United States)

    Bosler, T. L.

    2007-03-01

    The methodologies, creativity and intellectual capacity of today's physicists are becoming more and more relevant in the world of policy and politics. Some issues such as climate change, alternative energy and avian influenza clearly reveal the relevance of scientific knowledge and research in policy. However, the connection between science and issues such as electronic voting, government earmarks and international cooperation are not as obvious, but the role of scientists in these topics and their effects on science itself are critical. As the world becomes increasingly technological and global, the need for the involvement of scientists in the political process grows. The traditional scientific training of physicists emphasizes intense scrutiny of specific physical phenomena in the natural world but often misses the opportunity to utilize trained scientific minds on some of society's greatest problems. I will discuss the many ways in which scientists can contribute to society far beyond the academic community and the unique opportunities science policy work offers to the socially conscious scientist or even those just looking to get more grant money.

  7. Community development in primary care: opportunities and challenges.

    Science.gov (United States)

    Hogg, Rhona; Hanley, Janet

    2008-01-01

    This qualitative study aimed to explore primary health care professionals' views on community development, and to identify the opportunities and barriers associated with using this approach in practice. Participants in community development training--mainly health visitors--took part in small group discussions before, after, and six months following the training course. Opportunities for using a community development approach were identified, but were restricted by lack of interest from some communities, lack of leadership and support within health visiting, and by the increasing medicalisation of health promotion. There is a potential conflict between the ethos of community development and the aim of the national, policy-driven public agenda. Recommendations are suggested to change the organisation of health visiting in order to facilitate the adoption of public health approaches, including community development. These changes would enable health visitors to make use of the help which is readily available from recently appointed public health practitioners, whose role is to promote public health practice in primary health care.

  8. A new generation of healthcare buildings in South Africa: complexities and opportunities for greening

    CSIR Research Space (South Africa)

    De

    2012-07-01

    Full Text Available , efficient, healing environment desirable for healthcare delivery. In South Africa there has been a commitment to transform the healthcare sector through the introduction of the national health insurance system which is to be unfolded over a 14 year period...

  9. Clinical practice in community medicine: Challenges and opportunities

    Directory of Open Access Journals (Sweden)

    Rajesh Kumar

    2017-01-01

    Full Text Available Clinical practice with community health perspective makes community medicine a unique specialty. In their health centers, community physicians not only implement disease prevention programs, assess community health needs, manage healthcare teams and advocate for health promoting policies but also diagnose and treat diseases. However, participation of community medicine faculty in the delivery of clinical care varies from place to place due to administrative constraints. Health centers attached with medical college are not dependent on community medicine faculty for clinical service as these centers have their own medical and paramedical staff; whereas, other clinical departments in medical colleges depend on their faculty for delivery of clinical care in the hospital. Consequently, a perception is gaining ground that community medicine is a para-clinical specialty. Strategies for a fixed tenured rotation of faculty in the health centers should be evolved. All faculty members of community medicine must also provide clinical care in the health centers and the quantum of clinical services provided by each one of them should be reported widely to all stakeholders. Community medicine residency programs must ensure that trainee community physicians acquire competency to deliver comprehensive primary health care (promotive, preventive, curative, and rehabilitative in a health center.

  10. Clinical Practice in Community Medicine: Challenges and Opportunities.

    Science.gov (United States)

    Kumar, Rajesh

    2017-01-01

    Clinical practice with community health perspective makes community medicine a unique specialty. In their health centers, community physicians not only implement disease prevention programs, assess community health needs, manage healthcare teams and advocate for health promoting policies but also diagnose and treat diseases. However, participation of community medicine faculty in the delivery of clinical care varies from place to place due to administrative constraints. Health centers attached with medical college are not dependent on community medicine faculty for clinical service as these centers have their own medical and paramedical staff; whereas, other clinical departments in medical colleges depend on their faculty for delivery of clinical care in the hospital. Consequently, a perception is gaining ground that community medicine is a para-clinical specialty. Strategies for a fixed tenured rotation of faculty in the health centers should be evolved. All faculty members of community medicine must also provide clinical care in the health centers and the quantum of clinical services provided by each one of them should be reported widely to all stakeholders. Community medicine residency programs must ensure that trainee community physicians acquire competency to deliver comprehensive primary health care (promotive, preventive, curative, and rehabilitative) in a health center.

  11. Empowering Patients through Healthcare Technology and Information? The Challenge of becoming a Patient 2.0

    DEFF Research Database (Denmark)

    Brodersen, Søsser Grith Kragh; Lindegaard, Hanne

    2015-01-01

    on numerical representations of illness (i.e., metrics) than on direct observations of patients. Through ethnographic research in the Danish healthcare sector, we show how this new healthcare vision actually manifests in practice by presenting cases of elderly heart and diabetes patients. Technologies aimed......Abstract: In the mid-2000s, the term Patient 2.0 began to be used to denote a new patient role: empowered patients were expected to engage with various types of information and specific technologies in order to manage their own illnesses. Headlines such as Future patients will take care...... of themselves appeared in newspapers, and self-management and telecare technologies were seen as ways to change elderly patients practices. Transformation of the traditional healthcare system remains on the agenda, and it continues to challenge the traditional view of the patient role (framed in this article...

  12. Gender and leadership in healthcare administration: 21st century progress and challenges.

    Science.gov (United States)

    Lantz, Paula M

    2008-01-01

    The need for strong leadership and increased diversity is a prominent issue in today's health services workforce. This article reviews the latest literature, including research and proposed agendas, regarding women in executive healthcare leadership. Data suggest that the number of women in leadership roles is increasing, but women remain underrepresented in the top echelons of healthcare leadership, and gender differences exist in the types of leadership roles women do attain. Salary disparity prevails, even when controlling for gender differences in educational attainment, age, and experience. Despite widespread awareness of these problems in the field, current action and policy recommendations are severely lacking. Along with the challenges of cost, quality, and an aging population, the time has come for a more thoughtful, policy-focused approach to amend the discrepancy between gender and leadership in healthcare administration.

  13. Challenges of information security incident learning: An industrial case study in a Chinese healthcare organization.

    Science.gov (United States)

    He, Ying; Johnson, Chris

    2017-12-01

    Security incidents can have negative impacts on healthcare organizations, and the security of medical records has become a primary concern of the public. However, previous studies showed that organizations had not effectively learned lessons from security incidents. Incident learning as an essential activity in the "follow-up" phase of security incident response lifecycle has long been addressed but not given enough attention. This paper conducted a case study in a healthcare organization in China to explore their current obstacles in the practice of incident learning. We interviewed both IT professionals and healthcare professionals. The results showed that the organization did not have a structured way to gather and redistribute incident knowledge. Incident response was ineffective in cycling incident knowledge back to inform security management. Incident reporting to multiple stakeholders faced a great challenge. In response to this case study, we suggest the security assurance modeling framework to address those obstacles.

  14. E-Commerce Content in Business School Curriculum: Opportunities and Challenges.

    Science.gov (United States)

    Krovi, Ravindra; Vijayaraman, B. S.

    2000-01-01

    Explores the opportunities and challenges of introducing e-commerce concepts in business school curriculums. Examines the knowledge components of electronic commerce, including Web-based technology skills; and discusses the need for faculty training and development. (Author/LRW)

  15. The Fourth Wave of Digitalization and Public Transport: Opportunities and Challenges

    Directory of Open Access Journals (Sweden)

    Paul Davidsson

    2016-11-01

    Full Text Available We investigate the opportunities and challenges of the forth wave of digitalization, also referred to as the Internet of Things (IoT, with respect to public transport and how it can support sustainable development of society. Environmental, economical, and social perspectives are considered through analysis of the existing literature and explorative studies. We conclude that there are great opportunities for both transport operators and planners, as well as for the travelers. We describe and analyze a number of concrete opportunities for each of these actors. However, in order to realize these opportunities, there are also a number of challenges that needs to be addressed. There are both technical challenges, such as data collection issues, interoperability, scalability and information security, and non-technical challenges such as business models, usability, privacy issues, and deployment.

  16. Yeast culture collections in the twenty-first century: new opportunities and challenges

    NARCIS (Netherlands)

    Boundy-Mills, Kyria L.; Glantschnig, Ewald; Roberts, Ian N.; Yurkov, Andrey; Casaregola, Serge; Daniel, Heide-Marie; Groenewald, Marizeth; Turchetti, Benedetta

    The twenty-first century has brought new opportunities and challenges to yeast culture collections, whether they are long-standing or recently established. Basic functions such as archiving, characterizing and distributing yeasts continue, but with expanded responsibilities and emerging

  17. A short narrative - Challenges and opportunities in expanding research in the Middle East, North Afr

    Science.gov (United States)

    CGH CRTA, Hedieh Mehrtash interviews CGH's Dr. Marie Ricciardone who works with a network of partners in the Middle East and North Africa region, on experiences, challenges, and opportunities in the region.

  18. Buffer Sizing in Wireless Networks: Challenges, Solutions, and Opportunities

    KAUST Repository

    Showail, Ahmad

    2016-04-01

    Buffer sizing is an important network configuration parameter that impacts the Quality of Service (QoS) characteristics of data traffic. With falling memory costs and the fallacy that \\'more is better\\', network devices are being overprovisioned with large bu ers. This may increase queueing delays experienced by a packet and subsequently impact stability of core protocols such as TCP. The problem has been studied extensively for wired networks. However, there is little work addressing the unique challenges of wireless environment such as time-varying channel capacity, variable packet inter-service time, and packet aggregation, among others. In this paper we discuss these challenges, classify the current state-of-the-art solutions, discuss their limitations, and provide directions for future research in the area.

  19. Human embryonic stem cell registries: value, challenges and opportunities.

    Science.gov (United States)

    Luong, Mai X; Smith, Kelly P; Stein, Gary S

    2008-10-15

    The accelerating pace of human embryonic stem cell (hESC) research has created an urgent need for the development of hESC registries, information repositories intended to gather, organize and disseminate hESC information. Although of enormous value to this evolving field, registries face significant challenges to their development. These challenges include addressing the legal and ethical issues surrounding hESC derivation as well as complex intellectual property concerns. In addition to these issues, registries must develop tools to efficiently gather, validate and present many different types of hESC information from a variety of sources. Given the pace and regulatory complexities of this field, it is important that registries develop cooperative mechanisms to avoid duplication and more efficiently support hESC research. (c) 2008 Wiley-Liss, Inc.

  20. Reducing Weight for Transportation Applications: Technology Challenges and Opportunities

    Science.gov (United States)

    Taub, Alan I.

    Today's land, sea and air transportation industries — as a business necessity — are focused on technology solutions that will make vehicles more sustainable in terms of energy, the environment, safety and affordability. Reducing vehicle weight is a key enabler for meeting these challenges as well as increasing payload and improving performance. The potential weight reductions from substituting lightweight metals (advanced high-strength steels, aluminum, magnesium and titanium alloys) are well established. For magnesium castings, weight savings of 60% have been reported [1]. The value of weight reduction depends on the transportation sector and ranges from about 5/kg saved for automobiles to over 500/kg saved for aircraft [2]. The challenge is to optimize the material properties and develop robust, high volume, manufacturing technologies and the associated supply chain to fabricate components and subsystems at the appropriate cost for each application.

  1. Single-Molecule Sensors: Challenges and Opportunities for Quantitative Analysis.

    Science.gov (United States)

    Gooding, J Justin; Gaus, Katharina

    2016-09-12

    Measurement science has been converging to smaller and smaller samples, such that it is now possible to detect single molecules. This Review focuses on the next generation of analytical tools that combine single-molecule detection with the ability to measure many single molecules simultaneously and/or process larger and more complex samples. Such single-molecule sensors constitute a new type of quantitative analytical tool, as they perform analysis by molecular counting and thus potentially capture the heterogeneity of the sample. This Review outlines the advantages and potential of these new, quantitative single-molecule sensors, the measurement challenges in making single-molecule devices suitable for analysis, the inspiration biology provides for overcoming these challenges, and some of the solutions currently being explored. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Challenges and Opportunities for Research on Same-Sex Relationships.

    Science.gov (United States)

    Umberson, Debra; Thomeer, Mieke Beth; Kroeger, Rhiannon A; Lodge, Amy Caroline; Xu, Minle

    2015-02-01

    Research on same-sex relationships has informed policy debates and legal decisions that greatly affect American families, yet the data and methods available to scholars studying same-sex relationships have been limited. In this article the authors review current approaches to studying same-sex relationships and significant challenges for this research. After exploring how researchers have dealt with these challenges in prior studies, the authors discuss promising strategies and methods to advance future research on same-sex relationships, with particular attention given to gendered contexts and dyadic research designs, quasi-experimental designs, and a relationship biography approach. Innovation and advances in the study of same-sex relationships will further theoretical and empirical knowledge in family studies more broadly and increase understanding of different-sex as well as same-sex relationships.

  3. Synergy of Microfluidics and Ultrasound : Process Intensification Challenges and Opportunities.

    Science.gov (United States)

    Fernandez Rivas, David; Kuhn, Simon

    2016-10-01

    A compact snapshot of the current convergence of novel developments relevant to chemical engineering is given. Process intensification concepts are analysed through the lens of microfluidics and sonochemistry. Economical drivers and their influence on scientific activities are mentioned, including innovation opportunities towards deployment into society. We focus on the control of cavitation as a means to improve the energy efficiency of sonochemical reactors, as well as in the solids handling with ultrasound; both are considered the most difficult hurdles for its adoption in a practical and industrial sense. Particular examples for microfluidic clogging prevention, numbering-up and scaling-up strategies are given. To conclude, an outlook of possible new directions of this active and promising combination of technologies is hinted.

  4. Microscale technology and biocatalytic processes: opportunities and challenges for synthesis.

    Science.gov (United States)

    Wohlgemuth, Roland; Plazl, Igor; Žnidaršič-Plazl, Polona; Gernaey, Krist V; Woodley, John M

    2015-05-01

    Despite the expanding presence of microscale technology in chemical synthesis and energy production as well as in biomedical devices and analytical and diagnostic tools, its potential in biocatalytic processes for pharmaceutical and fine chemicals, as well as related industries, has not yet been fully exploited. The aim of this review is to shed light on the strategic advantages of this promising technology for the development and realization of biocatalytic processes and subsequent product recovery steps, demonstrated with examples from the literature. Constraints, opportunities, and the future outlook for the implementation of these key green engineering methods and the role of supporting tools such as mathematical models to establish sustainable production processes are discussed. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Japanese Martial Arts as Popular Culture: Teaching Opportunity and Challenge

    Directory of Open Access Journals (Sweden)

    Stephen Robert NAGY

    2015-07-01

    Full Text Available Japanese martial arts, here after Japanese budō, are popular cultural icons that are found in films, comics, video games and books. Teaching Japanese budō at university offers a novel way to teach about East Asian and in particular Japanese culture, history, and philosophy while including ideas about the globalization and the localization of culture. Question though remains as to how and what should we teach about the popular culture of Japanese budō at the university level? This paper found that a comprehensive approach to teaching about budō was effective. By using many kinds of materials and the incorporation of opportunities to experience budō and to try budō, students were better able to grasp the historical, cultural and religious characteristics of budō.

  6. Metaphotonics: An emerging field with opportunities and challenges

    Science.gov (United States)

    Baev, Alexander; Prasad, Paras N.; Ågren, Hans; Samoć, Marek; Wegener, Martin

    2015-09-01

    Metaphotonics is an emerging multidisciplinary field that deals with manipulation of electro-magnetic fields in nanoengineered (meta)materials using both electric and magnetic interactions and their cross-coupling. It offers unprecedented control of both linear and nonlinear optical functions for applications ranging from optical switching, to negative- and near-zero refractive index metamaterials, to chiral bioimaging, to cloaking. However, realization of such applications requires physics-guided nanoengineering of appropriate artificial media with electro-magnetic properties at visible and infrared wavelengths that are tailored to surpass those of any naturally-occurring material. Here, we review metaphotonics with a broadened vision and scope, introduce potential applications, describe the role of theoretical physics through multiscale modeling, review the materials development and current status, and outline opportunities in this fertile emerging field.

  7. Bringing medicinal plants into cultivation: opportunities and challenges for biotechnology.

    Science.gov (United States)

    Canter, Peter H; Thomas, Howard; Ernst, Edzard

    2005-04-01

    Consumption of herbal medicines is widespread and increasing. Harvesting from the wild, the main source of raw material, is causing loss of genetic diversity and habitat destruction. Domestic cultivation is a viable alternative and offers the opportunity to overcome the problems that are inherent in herbal extracts: misidentification, genetic and phenotypic variability, extract variability and instability, toxic components and contaminants. The use of controlled environments can overcome cultivation difficulties and could be a means to manipulate phenotypic variation in bioactive compounds and toxins. Conventional plant-breeding methods can improve both agronomic and medicinal traits, and molecular marker assisted selection will be used increasingly. There has been significant progress in the use of tissue culture and genetic transformation to alter pathways for the biosynthesis of target metabolites. Obstacles to bringing medicinal plants into successful commercial cultivation include the difficulty of predicting which extracts will remain marketable and the likely market preference for what is seen as naturally sourced extracts.

  8. Quantifying temporal change in biodiversity: challenges and opportunities

    Science.gov (United States)

    Dornelas, Maria; Magurran, Anne E.; Buckland, Stephen T.; Chao, Anne; Chazdon, Robin L.; Colwell, Robert K.; Curtis, Tom; Gaston, Kevin J.; Gotelli, Nicholas J.; Kosnik, Matthew A.; McGill, Brian; McCune, Jenny L.; Morlon, Hélène; Mumby, Peter J.; Øvreås, Lise; Studeny, Angelika; Vellend, Mark

    2013-01-01

    Growing concern about biodiversity loss underscores the need to quantify and understand temporal change. Here, we review the opportunities presented by biodiversity time series, and address three related issues: (i) recognizing the characteristics of temporal data; (ii) selecting appropriate statistical procedures for analysing temporal data; and (iii) inferring and forecasting biodiversity change. With regard to the first issue, we draw attention to defining characteristics of biodiversity time series—lack of physical boundaries, uni-dimensionality, autocorrelation and directionality—that inform the choice of analytic methods. Second, we explore methods of quantifying change in biodiversity at different timescales, noting that autocorrelation can be viewed as a feature that sheds light on the underlying structure of temporal change. Finally, we address the transition from inferring to forecasting biodiversity change, highlighting potential pitfalls associated with phase-shifts and novel conditions. PMID:23097514

  9. Grand Challenges and Future Opportunities for Metal?Organic Frameworks

    OpenAIRE

    Hendon, Christopher H.; Rieth, Adam J.; Maciej D. Korzyński; Dinc?, Mircea

    2017-01-01

    Metal?organic frameworks (MOFs) allow compositional and structural diversity beyond conventional solid-state materials. Continued interest in the field is justified by potential applications of exceptional breadth, ranging from gas storage and separation, which takes advantage of the inherent pores and their volume, to electronic applications, which requires precise control of electronic structure. In this Outlook we present some of the pertinent challenges that MOFs face in their conventiona...

  10. Opportunities and Challenges in Deep Mining: A Brief Review

    OpenAIRE

    Pathegama G. Ranjith; Jian Zhao; Minghe Ju; Radhika V.S. De Silva; Tharaka D. Rathnaweera; Adheesha K.M.S. Bandara

    2017-01-01

    Mineral consumption is increasing rapidly as more consumers enter the market for minerals and as the global standard of living increases. As a result, underground mining continues to progress to deeper levels in order to tackle the mineral supply crisis in the 21st century. However, deep mining occurs in a very technical and challenging environment, in which significant innovative solutions and best practice are required and additional safety standards must be implemented in order to overcome...

  11. Opportunities and challenges of mobile learning for promoting mathematical literacy

    OpenAIRE

    abidin, zaenal; Mathrani, Anuradha; Parsons, David; Suriadi, Suriadi

    2016-01-01

    Mathematical literacy plays an important role in supporting individuals to fulfil their professional roles in modern society. The affordances of mobile technologies as well as the emergence of new theories in mobile learning have the potential to promote mathematical literacy. However, implementation of mobile learning in Indonesian society faces challenges related to perceived ethical and learning issues in curriculum-based educational settings. This study aims to investigate the preparednes...

  12. Opportunities and challenges in screening for childhood sexual abuse.

    Science.gov (United States)

    Sekhar, Deepa L; Kraschnewski, Jennifer L; Stuckey, Heather L; Witt, Pamela D; Francis, Erica B; Moore, Ginger A; Morgan, Paul L; Noll, Jennie G

    2017-08-11

    Retrospective studies suggest 1 in 4 girls and 1 in 6 boys will experience sexual abuse before 18 years of age, resulting in future morbidity. Successful interventions exist, however, victims are reluctant to disclose. Screening for childhood sexual abuse (CSA) may provide an opportunity to overcome this barrier, yet no current model for universal CSA screening exists. We sought to understand the perspective of key stakeholders on CSA screening through qualitative research. Eight focus groups of 7-10 participants each (n=62) were conducted from April-September 2016. Stakeholders included school nurses, school teachers, counselors and administrators, pediatric providers, and parents. The interview guide focused on reporting suspected CSA and impressions of a CSA screening tool. Sessions were audiotaped and transcribed. Researchers used qualitative content analysis to develop conceptual categories that related to CSA screening and reporting. Two research team members independently open-coded 20% of the data for interrater reliability (kappa=0.98) prior to completing the coding process. Three major categories emerged to inform CSA screening. First, early screening (e.g. kindergarten) was preferred. Confidentiality was a concern, specifically privacy in the school-setting. As CSA perpetrators are often known to the child, parental presence in the medical office was also a concern. Finally, refinement of the screening process was discussed starting with routine education on safe touch and defining "normal." Rather than direct questioning, consistent and repeated offering of opportunities to disclose CSA and identification of a trusted adult were suggested. Next steps should involve partnering with evidence-based CSA prevention programs to incorporate and evaluate the aforementioned elements. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Renewable energy scenario in India: Opportunities and challenges

    Science.gov (United States)

    Sen, Souvik; Ganguly, Sourav; Das, Ayanangshu; Sen, Joyjeet; Dey, Sourav

    2016-10-01

    Majority of the power generation in India is carried out by conventional energy sources, coal and fossil fuels being the primary ones, which contribute heavily to greenhouse gas emission and global warming. The Indian power sector is witnessing a revolution as excitement grips the nation about harnessing electricity from various renewable energy sources. Electricity generation from renewable sources is increasingly recognized to play an important role for the achievement of a variety of primary and secondary energy policy goals, such as improved diversity and security of energy supply, reduction of local pollutant and global greenhouse gas emissions, regional and rural development, and exploitation of opportunities for fostering social cohesion, value addition and employment generation at the local and regional level. This focuses the solution of the energy crisis on judicious utilization of abundant the renewable energy resources, such as biomass, solar, wind, geothermal and ocean tidal energy. This paper reviews the renewable energy scenario of India as well as extrapolates the future developments keeping in view the consumption, production and supply of power. Research, development, production and demonstration have been carried out enthusiastically in India to find a feasible solution to the perennial problem of power shortage for the past three decades. India has obtained application of a variety of renewable energy technologies for use in different sectors too. There are ample opportunities with favorable geology and geography with huge customer base and widening gap between demand and supply. Technological advancement, suitable regulatory policies, tax rebates, efficiency improvement in consequence to R&D efforts are the few pathways to energy and environment conservation and it will ensure that these large, clean resource bases are exploited as quickly and cost effectively as possible. This paper gives an overview of the potential renewable energy resources

  14. Experiences of Military Youth during a Family Member's Deployment: Changes, Challenges, and Opportunities

    Science.gov (United States)

    Knobloch, Leanne K.; Pusateri, Kimberly B.; Ebata, Aaron T.; McGlaughlin, Patricia C.

    2015-01-01

    The deployment of a family member can be very distressing for military children, but it also can supply opportunities for growth. This study addresses calls for research on the changes, challenges, and opportunities facing youth during a family member's tour of duty. It uses the relational turbulence model to frame research questions about how…

  15. DoD Installations, Energy and the Environment: The Challenge - and Opportunity

    Science.gov (United States)

    2010-06-15

    DoD Installations, Energy and the Environment : The Challenge—and Opportunity Dorothy Robyn Deputy Under Secretary of Defense (Installations and... the Environment : The Challenge - and Opportunity 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER

  16. Prospects, achievements, challenges and opportunities for scaling-up malaria chemoprevention in pregnancy in Tanzania

    DEFF Research Database (Denmark)

    Mubyazi, Godfrey M.; Bygbjerg, Ib Christian; Magnussen, Pascal

    2008-01-01

    To describe the prospects, achievements, challenges and opportunities for implementing intermittent preventive treatment for malaria in pregnancy (IPTp) in Tanzania in light of national antenatal care (ANC) guidelines and ability of service providers to comply with them.......To describe the prospects, achievements, challenges and opportunities for implementing intermittent preventive treatment for malaria in pregnancy (IPTp) in Tanzania in light of national antenatal care (ANC) guidelines and ability of service providers to comply with them....

  17. Sentiment analysis in medical settings: New opportunities and challenges.

    Science.gov (United States)

    Denecke, Kerstin; Deng, Yihan

    2015-05-01

    Clinical documents reflect a patient's health status in terms of observations and contain objective information such as descriptions of examination results, diagnoses and interventions. To evaluate this information properly, assessing positive or negative clinical outcomes or judging the impact of a medical condition on patient's well being are essential. Although methods of sentiment analysis have been developed to address these tasks, they have not yet found broad application in the medical domain. In this work, we characterize the facets of sentiment in the medical sphere and identify potential use cases. Through a literature review, we summarize the state of the art in healthcare settings. To determine the linguistic peculiarities of sentiment in medical texts and to collect open research questions of sentiment analysis in medicine, we perform a quantitative assessment with respect to word usage and sentiment distribution of a dataset of clinical narratives and medical social media derived from six different sources. Word usage in clinical narratives differs from that in medical social media: Nouns predominate. Even though adjectives are also frequently used, they mainly describe body locations. Between 12% and 15% of sentiment terms are determined in medical social media datasets when applying existing sentiment lexicons. In contrast, in clinical narratives only between 5% and 11% opinionated terms were identified. This proves the less subjective use of language in clinical narratives, requiring adaptations to existing methods for sentiment analysis. Medical sentiment concerns the patient's health status, medical conditions and treatment. Its analysis and extraction from texts has multiple applications, even for clinical narratives that remained so far unconsidered. Given the varying usage and meanings of terms, sentiment analysis from medical documents requires a domain-specific sentiment source and complementary context-dependent features to be able to

  18. Opportunities and challenges for enhancing preconception health in primary care: qualitative study with women from ethnically diverse communities

    Science.gov (United States)

    Tuomainen, Helena; Cross-Bardell, Laura; Bhoday, Mandeep; Qureshi, Nadeem; Kai, Joe

    2013-01-01

    Objective  There is a growing interest in developing and offering more systematic preconception healthcare. However, it is unclear how this might be regarded by ethnically diverse communities at higher risk of poor maternal and child health outcomes. We sought to explore perceptions about preconception health and care among women from these communities to identify opportunities and challenges for intervention development in primary care. Design Qualitative study using focus groups and semistructured interviews. Setting Ethnically diverse and socially disadvantaged community settings of the UK. Participants 41 women aged 18–45 years, of Pakistani, Indian, Caribbean, African, White and mixed ethnic origin, participating in nine focus groups, half of whom (n=19) had one-to-one follow-up telephone interviews. Results Women had modest or poor awareness of preconception health issues. They perceived these could be addressed in primary care, particularly if raised within a range of clinically ‘relevant’ consultations, such as for contraception, or when opportune for individuals in their social context. However, challenges for engaging women in preconception care more routinely were underlined. These included little prevailing culture of preparing for pregnancy and the realities of their pregnancies often being unplanned; and, for those planning pregnancy, sensitivity and maintaining secrecy when trying to conceive. A preference for female professionals, engaging men, and enhancing access for younger people or women less disposed to general practice, in educational and other settings were highlighted. Conclusions Raising preconception health when this has heightened clinical or social resonance for women may hold promise for initiating more systematic intervention. In primary care this could offer greater potential to directly engage those with low awareness or not considering pregnancy, while enlarging opportunity for others who may be seeking to conceive

  19. Beyond wishful thinking; medical community presence on the web and challenges of pervasive healthcare.

    Science.gov (United States)

    Moisil, Ioana; Barbat, Boldur E

    2004-01-01

    Romanian healthcare is facing a number of challenges, from the growing general costs, through requests for better services, inadequate territorial coverage, medical errors and a growing incidence of chronic diseases, to the burden of debt toward the pharmaceutical industry. For the last 14 years decision factors have been searching for the magic formula in restructuring the healthcare sector. Eventually, the government has come to appreciate the benefits of IT solutions. Our paper presents recent advances in wireless technologies and their impact on healthcare, in parallel with the results of a study aimed to acknowledge the presence of the medical community on Romanian WWW and to evaluate the degree of accessibility for the general population. We have documented Web sites promoting health services, discussion forums for patients, online medical advice, medical image teleprocessing, health education, health research and documentation, pharmaceutical products, e-procurement, health portals, medical links, hospitals and other health units present on the Web. Initial results have shown that if the current trend in price decreases for mobile communications continues and if the government is able to provide funding for the communication infrastructure needed for pervasive healthcare systems together with the appropriate regulations and standards, this can be a long-term viable solution of the healthcare crisis.

  20. "A challenge" - healthcare professionals' experiences when meeting women with symptoms that might indicate endometriosis.

    Science.gov (United States)

    Grundström, Hanna; Kjølhede, Preben; Berterö, Carina; Alehagen, Siw

    2016-03-01

    The aim of the study was to identify and describe the experiences of healthcare professionals when meeting women with symptoms that might indicate endometriosis. Semi-structured interviews were conducted with 10 gynecologists, six general practitioners and nine midwives working at one university hospital, one central hospital, one private gynecology clinic and five healthcare centers in south-east Sweden. The interviews were recorded and transcribed verbatim and analyzed using qualitative conventional content analysis. Three clusters were identified: the corroborating encounter, the normal variation of menstruation cycles, and the suspicion of endometriosis. The healthcare professionals tried to make a corroborating encounter by acknowledging the woman, taking time to listen, and giving an explanation for the problems. Healthcare professionals had different ways to determine what was normal as regards menstrual pain, ovulation pain and dyspareunia. They also needed to have the competence to act and react when the symptoms indicated endometriosis. Meeting women with symptoms that might indicate endometriosis is challenging and demands a certain level of competence from healthcare professionals. Sometimes the symptoms are camouflaged as "normal" menstruation pain, making it hard to satisfy the needs of this patient group. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. The influence of social challenges when implementing information systems in a Swedish health-care organisation.

    Science.gov (United States)

    Nilsson, Lina; Eriksén, Sara; Borg, Christel

    2016-09-01

    To describe and obtain a deeper understanding of social challenges and their influence on the implementation process when implementing Information systems in a Swedish health-care organisation. Despite positive effects when implementing Information systems in health-care organisations, there are difficulties in the implementation process. Nurses' experiences of being neglected have been dismissed as reasons for setbacks in implementation. An Institutional Ethnography design was used. A deductive content analysis was made influenced by empirically identified social challenges of power, professional identity and encounters. An abstraction was made of the analysis. Nineteen nurses at macro, meso and micro levels were interviewed in focus groups. Organisational levels are lost in different ways in how to control the reformation, how to introduce Information systems as reformation strategies and in how to translate new tools and assumptions that do not fit traditional ways of working in shaping professional identities. Different focus may affect the reformation of health-care organisations and implementation and knowledge processes. An implementation climate is needed where the system standards fit the values of the users. Nursing management needs to be visionary, engaged and work with risk factors in order to reform the hierarchical health-care organisation. © 2016 John Wiley & Sons Ltd.

  2. Preclinical Mouse Cancer Models: A Maze of Opportunities and Challenges

    Science.gov (United States)

    Day, Chi-Ping; Merlino, Glenn; Van Dyke, Terry

    2015-01-01

    Significant advances have been made in developing novel therapeutics for cancer treatment, and targeted therapies have revolutionized the treatment of some cancers. Despite the promise, only about five percent of new cancer drugs are approved, and most fail due to lack of efficacy. The indication is that current preclinical methods are limited in predicting successful outcomes. Such failure exacts enormous cost, both financial and in the quality of human life. This primer explores the current status, promise and challenges of preclinical evaluation in advanced mouse cancer models and briefly addresses emerging models for early-stage preclinical development. PMID:26406370

  3. 'Big data' in pharmaceutical science: challenges and opportunities.

    Science.gov (United States)

    Dossetter, Al G; Ecker, Gerhard; Laverty, Hugh; Overington, John

    2014-05-01

    Future Medicinal Chemistry invited a selection of experts to express their views on the current impact of big data in drug discovery and design, as well as speculate on future developments in the field. The topics discussed include the challenges of implementing big data technologies, maintaining the quality and privacy of data sets, and how the industry will need to adapt to welcome the big data era. Their enlightening responses provide a snapshot of the many and varied contributions being made by big data to the advancement of pharmaceutical science.

  4. Gas-fired Power Generation in India: Challenges and opportunities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    India's fast growing economy needs to add 100,000 MW power generating capacity between 2002-2012. Given limitations to the use of coal in terms of environmental considerations, quality and supply constraints, gas is expected to play an increasingly important role in India's power sector. This report briefs NMC Delegates on the potential for gas-fired power generation in India and describes the challenges India faces to translate the potential for gas-fired power generation into reality.

  5. Resilience of primary healthcare professionals working in challenging environments: a focus group study.

    Science.gov (United States)

    Matheson, Catriona; Robertson, Helen D; Elliott, Alison M; Iversen, Lisa; Murchie, Peter

    2016-07-01

    The modern primary healthcare workforce needs to be resilient. Early research framed professional resilience as avoiding 'burnout'; however, more recent literature has introduced the concept of positive adaptation to professional challenges, which results in individuals thriving in their role. To explore what primary health professionals working in challenging environments consider to be characteristics of resilience and what promotes or challenges professional resilience. A qualitative focus group in north east Scotland. Five focus groups were held with 20 health professionals (six GPs, nine nurses, four pharmacists, and a practice manager) based in rural or deprived city areas in the north east of Scotland. Inductive thematic analysis identified emerging themes. Personal resilience characteristics identified were optimism, flexibility and adaptability, initiative, tolerance, organisational skills, being a team worker, keeping within professional boundaries, assertiveness, humour, and a sense of self-worth. Workplace challenges were workload, information overload, time pressures, poor communication, challenging patients, and environmental factors (rural location). Promoters of professional resilience were strong management support, teamwork, workplace buffers, and social factors such as friends, family, and leisure activities. A model of health professional resilience is proposed that concurs with existing literature but adds the concept of personal traits being synergistic with workplace features and social networks. These facilitate adaptability and enable individual health professionals to cope with adversity that is inevitably part of the everyday experience of those working in challenging healthcare environments. © British Journal of General Practice 2016.

  6. van der Waals Layered Materials: Opportunities and Challenges.

    Science.gov (United States)

    Duong, Dinh Loc; Yun, Seok Joon; Lee, Young Hee

    2017-12-26

    Since graphene became available by a scotch tape technique, a vast class of two-dimensional (2D) van der Waals (vdW) layered materials has been researched intensively. What is more intriguing is that the well-known physics and chemistry of three-dimensional (3D) bulk materials are often irrelevant, revealing exotic phenomena in 2D vdW materials. By further constructing heterostructures of these materials in the planar and vertical directions, which can be easily achieved via simple exfoliation techniques, numerous quantum mechanical devices have been demonstrated for fundamental research and technological applications. It is, therefore, necessary to review the special features in 2D vdW materials and to discuss the remaining issues and challenges. Here, we review the vdW materials library, technology relevance, and specialties of vdW materials covering the vdW interaction, strong Coulomb interaction, layer dependence, dielectric screening engineering, work function modulation, phase engineering, heterostructures, stability, growth issues, and the remaining challenges.

  7. E-book usage: counting the challenges and opportunities

    Directory of Open Access Journals (Sweden)

    Angela Conyers

    2017-07-01

    Full Text Available Academic libraries are spending a growing proportion of their increasingly stretched budgets on e-books each year. Within this context, demonstrating a return on investment is imperative, but gathering data about e-resource usage is not always easy.    This article summarizes how libraries and library consortia are acquiring and evaluating e-books, how usage statistics feature within library workflows, the issues faced in doing so and the resulting impact of these issues on understanding usage and informing purchasing of new titles. Discussions with publishers indicate how usage data are being used within the organization, the requirements of customers and the challenges involved in providing usage data for e-books. Assessing and evaluating e-book usage is a complex and challenging task with processes and workflows in development. A transition from print to e-books represents a significant change for libraries, and the availability of reliable usage statistics to support purchase decisions is vital. The article is based on a series of case study interviews with representatives from a small cross-section of academic libraries, library consortia, publishers and aggregators.    This work is of interest to anyone with responsibility for creating, managing, developing, delivering and supporting usage statistics and standards for e-books.

  8. Stem cell-based therapies for osteoarthritis: challenges and opportunities.

    Science.gov (United States)

    Diekman, Brian O; Guilak, Farshid

    2013-01-01

    Regenerative medicine offers the exciting potential of developing alternatives to total joint replacement for treating osteoarthritis. In this article, we highlight recent work that addresses key challenges of stem cell-based therapies for osteoarthritis and provide examples of innovative ways in which stem cells can aid in the treatment of osteoarthritis. Significant progress has been made in understanding the challenges to successful stem cell therapy, such as the effects of age or disease on stem cell properties, altered stem cell function due to an inflammatory joint environment and phenotypic instability in vivo. Novel scaffold designs have been shown to enhance the mechanical properties of tissue-engineered cartilage and have also improved the integration of newly formed tissue within the joint. Emerging strategies such as injecting stem cells directly into the joint, manipulating endogenous stem cells to enhance regenerative capacity and utilizing stem cells for drug discovery have expanded the potential uses of stem cells in treating osteoarthritis. Several recent studies have greatly advanced the development and preclinical evaluation of potential stem cell-based treatments for osteoarthritis through novel approaches focused on cell therapy, tissue engineering and drug discovery.

  9. Drug discovery for autism spectrum disorder: challenges and opportunities.

    Science.gov (United States)

    Ghosh, Anirvan; Michalon, Aubin; Lindemann, Lothar; Fontoura, Paulo; Santarelli, Luca

    2013-10-01

    The rising rates of autism spectrum disorder (ASD) and the lack of effective medications to treat its core symptoms have led to an increased sense of urgency to identify therapies for this group of neurodevelopmental conditions. Developing drugs for ASD, however, has been challenging because of a limited understanding of its pathophysiology, difficulties in modelling the disease in vitro and in vivo, the heterogeneity of symptoms, and the dearth of prior experience in clinical development. In the past few years these challenges have been mitigated by considerable advances in our understanding of forms of ASD caused by single-gene alterations, such as fragile X syndrome and tuberous sclerosis. In these cases we have gained insights into the pathophysiological mechanisms underlying these conditions. In addition, they have aided in the development of animal models and compounds with the potential for disease modification in clinical development. Moreover, genetic studies are illuminating the molecular pathophysiology of ASD, and new tools such as induced pluripotent stem cells offer novel possibilities for drug screening and disease diagnostics. Finally, large-scale collaborations between academia and industry are starting to address some of the key barriers to developing drugs for ASD. Here, we propose a conceptual framework for drug discovery in ASD encompassing target identification, drug profiling and considerations for clinical trials in this novel area.

  10. Genetically modified T cells in cancer therapy: opportunities and challenges

    Science.gov (United States)

    Sharpe, Michaela; Mount, Natalie

    2015-01-01

    Tumours use many strategies to evade the host immune response, including downregulation or weak immunogenicity of target antigens and creation of an immune-suppressive tumour environment. T cells play a key role in cell-mediated immunity and, recently, strategies to genetically modify T cells either through altering the specificity of the T cell receptor (TCR) or through introducing antibody-like recognition in chimeric antigen receptors (CARs) have made substantial advances. The potential of these approaches has been demonstrated in particular by the successful use of genetically modified T cells to treat B cell haematological malignancies in clinical trials. This clinical success is reflected in the growing number of strategic partnerships in this area that have attracted a high level of investment and involve large pharmaceutical organisations. Although our understanding of the factors that influence the safety and efficacy of these therapies has increased, challenges for bringing genetically modified T-cell immunotherapy to many patients with different tumour types remain. These challenges range from the selection of antigen targets and dealing with regulatory and safety issues to successfully navigating the routes to commercial development. However, the encouraging clinical data, the progress in the scientific understanding of tumour immunology and the improvements in the manufacture of cell products are all advancing the clinical translation of these important cellular immunotherapies. PMID:26035842

  11. Undirected, Homogeneous C-H Bond Functionalization: Challenges and Opportunities.

    Science.gov (United States)

    Hartwig, John F; Larsen, Matthew A

    2016-05-25

    The functionalization of C-H bonds has created new approaches to preparing organic molecules by enabling new strategic "disconnections" during the planning of a synthetic route. Such functionalizations also have created the ability to derivatize complex molecules by modifying one or more of the many C-H bonds. For these reasons, researchers are developing new types of functionalization reactions of C-H bonds and new applications of these processes. These C-H bond functionalization reactions can be divided into two general classes: those directed by coordination to an existing functional group prior to the cleavage of the C-H bond (directed) and those occurring without coordination prior to cleavage of the C-H bond (undirected). The undirected functionalizations of C-H bonds are much less common and more challenging to develop than the directed reactions. This outlook will focus on undirected C-H bond functionalization, as well as related reactions that occur by a noncovalent association of the catalyst prior to C-H bond cleavage. The inherent challenges of conducting undirected functionalizations of C-H bonds and the methods for undirected functionalization that are being developed will be presented, along with the factors that govern selectivity in these reactions. Finally, this outlook discusses future directions for research on undirected C-H functionalization, with an emphasis on the limitations that must be overcome if this type of methodology is to become widely used in academia and in industry.

  12. Pickering emulsions: challenges and opportunities in topical delivery.

    Science.gov (United States)

    Marto, Joana; Ascenso, Andreia; Simoes, Sandra; Almeida, António J; Ribeiro, Helena M

    2016-08-01

    Topical drug delivery is a challenging area with many advantages such as avoidance of first passage effect, stabilization of blood concentrations and attainment of local therapeutic effect with fewer side effects. Despite all these advantages, topical drug delivery remains limited to few molecules, since skin acts as a barrier to the delivery of many therapeutic molecules. To overcome this obstacle, a favored strategy relies on selecting suitable vehicles for dermatologic therapy, such as emulsions, gels and, more recently, nanoparticulate systems. Particle-stabilized emulsions, also known as Pickering emulsions, have garnered interest in recent years. Although most of the investigation on Pickering emulsions has been based on model systems with inorganic or organic solid particles, recent advances have been made regarding the application of nanocarriers, protein-based particles or cyclodextrins for this purpose. This review reports the latest advances in Pickering emulsions technical challenges, and discusses the potential benefits and drawbacks of using these formulations for topical pharmaceutical and cosmetic applications as an alternative to conventional surfactant-based systems. Pickering emulsions appear as a multifunctional dosage form with endless advantages. A great deal of progress is expected in this area, which might represent a renewed vision for the pharmaceutical and cosmetic industry.

  13. Obesity and Breast Cancer Prognosis: Evidence, Challenges, and Opportunities.

    Science.gov (United States)

    Jiralerspong, Sao; Goodwin, Pamela J

    2016-12-10

    Purpose To summarize the evidence of an association between obesity and breast cancer prognosis. Methods We reviewed the literature regarding overweight and obesity and breast cancer survival outcomes, overall and with regard to breast cancer subtypes, breast cancer therapies, biologic mechanisms, and possible interventions. We summarize our findings and provide clinical management recommendations. Results Obesity is associated with a 35% to 40% increased risk of breast cancer recurrence and death and therefore poorer survival outcomes. This is most clearly established for estrogen receptor-positive breast cancer, with the relationship in triple-negative and human epidermal growth factor receptor 2-positive subtypes less well established. A range of biologic mechanisms that may underlie this association has been identified. Weight loss and lifestyle interventions, as well as metformin and other obesity-targeted therapies, are promising avenues that require further study. Conclusion Obesity is associated with inferior survival in breast cancer. Understanding the nature and mechanisms of this effect provides an important opportunity for interventions to improve the diagnosis, treatment, and outcomes of obese patients with breast cancer.

  14. Postmodernism and the Church: An Opportunity and a Challenge

    Directory of Open Access Journals (Sweden)

    Timothy Hynes

    2016-09-01

    Full Text Available Postmodernism is, in many respects, a term that has lost most of its cultural and academic cachet. This does not, however, mean that the themes, context, and conditions to which it referred are no longer relevant. In this essay, I will briefly review the latest reports which show a decreasing interest in organized religion, and interpret these results as symptomatic of a larger change in the state of knowledge. To this end, I will examine Jean ‑François Lyotard’s analysis of the loss of metanarratives as a way of understanding the implicit rules of the dialogue that occurs between the theist and the atheist or agnostic. Next, I will note the unique capacity of beauty to transcend the diverse language games played by both sides of the conversation. I will conclude by contending that this characteristic of beauty offers a kind of common ground which can be built upon, fostering further dialogue as well as an opportunity for evangelization.

  15. Superefficient Refrigerators: Opportunities and Challenges for Efficiency Improvement Globally

    Energy Technology Data Exchange (ETDEWEB)

    Shah, Nihar; Park, Won Young; Bojda, Nicholas; McNeil, Michael A.

    2014-08-01

    As an energy-intensive mainstream product, residential refrigerators present a significant opportunity to reduce electricity consumption through energy efficiency improvements. Refrigerators expend a considerable amount of electricity during normal use, typically consuming between 100 to 1,000 kWh of electricity per annum. This paper presents the results of a technical analysis done for refrigerators in support of the Super-efficient Equipment and Appliance Deployment (SEAD) initiative. Beginning from a base case representative of the average unit sold in India, we analyze efficiency improvement options and their corresponding costs to build a cost-versus-efficiency relationship. We then consider design improvement options that are known to be the most cost effective and that can improve efficiency given current design configurations. We also analyze and present additional super-efficient options, such as vacuum-insulated panels. We estimate the cost of conserved electricity for the various options, allowing flexible program design for market transformation programs toward higher efficiency. We estimate ~;;160TWh/year of energy savings are cost effective in 2030, indicating significant potential for efficiency improvement in refrigerators in SEAD economies and China.

  16. DCFTA Implementation: Opportunities and Challenges for Ukrainian Entrepreneurs

    Directory of Open Access Journals (Sweden)

    Oleksandr KUBATKO

    2016-12-01

    Full Text Available The paper deals with the analysis of Ukrainian entrepreneurs readiness for implementation of Deep and Comprehensive Free Trade Area (DCFTA. The authors analyzed the ongoing condition for running business in Ukraine, and results were in favor negative industrial business tendencies combined with macroeconomic instability. Moreover, the military confrontation in the East of Ukraine has had negative consequences for the social, moral and economic situation in the country. Authors have estimated the chances and goals of Ukrainian entrepreneurs to be achieved using the DCFTA. Thus, the effect of DCFTA implementation could provide 6 % of the additional GDP in the medium term. The share of export to EU in total Ukrainian export of goods and services has increased from 26.7 % in 2013 to 32.8 % in 2015. The entrepreneurs of agriculture sector and textile industry are expected to receive the most positive effect of DCFTA implementation. Thus, the export of the cereal crops has increased by 3 % in 2015 compare with 2013. In addition, the export of Electrical machinery and equipment also has increased by 3% in 2015 comparing to 2013. Moreover, DCFTA implementation allowed opening new boundaries and opportunities for entrepreneurs in IT sector. At the same time, the machine building industry is expected to be very sensitive to the DCFTA implementation due the low competitiveness.

  17. Challenges and opportunities in polymer technology applied to veterinary medicine.

    Science.gov (United States)

    Bermudez, J M; Cid, A G; Ramírez-Rigo, M V; Quinteros, D; Simonazzi, A; Sánchez Bruni, S; Palma, S

    2014-04-01

    An important frontier in the administration of therapeutic drugs to veterinary species is the use of different polymers as drug delivery platforms. The usefulness of polymers as platforms for the administration of pharmaceutical and agricultural agents has been clearly recognized in the recent decades. The chemical versatility of polymers and the wide range of developed controlled-release strategies enhance the possibilities for the formulation of active molecules. In particular, the veterinary area offers opportunities for the development of novel controlled-release drug delivery technologies adapted to livestock or companion animal health needs. In some cases, it also allows to improve profitability in meat production or to meet the safety criteria related to drug residues. A number of factors affect the selection of polymers and subsequent properties of the controlled-release drug delivery system. However, their selection also dictates the release kinetics of the drug from the delivery system. Such choices are therefore crucial as they affect the success and potential of the delivery system for achieving the therapeutic goals of the veterinarian. It is the intention of this review to give an overview of the most relevant polymers, which are used or have been tested as drug delivery release rate modifiers in the veterinary field. The article highlights some recent developments focusing on their advantages and applications and analyzes the future direction of the scientific and technological advancements in this area. © 2013 John Wiley & Sons Ltd.

  18. Change, Challenge and Opportunity: Departments of Medicine and Their Leaders.

    Science.gov (United States)

    Feussner, John R; Landefeld, C Seth; Weinberger, Steven E

    2016-01-01

    Academic Health Centers are evolving to larger and more complex Academic Health Systems (AHS), reflecting financial stresses requiring them to become nimble, efficient, and patient (consumer) and faculty (employee) focused. The evolving AHS organization includes many positive attributes: unity of purpose, structural integration, collaboration and teamwork, alignment of goals with resource allocation, and increased financial success. The organization, leadership, and business acumen of the AHS influence directly opportunities for Departments of Medicine. Just as leadership capabilities of the AHS affect its future success, the same is true for departmental leadership. The Department of Medicine is no longer a quasi- autonomous entity, and the chairperson is no longer an independent decision-maker. Departments of Medicine will be most successful if they maintain internal unity and cohesion by not fragmenting along specialty lines. Departments with larger endowments or those with public financial support have more flexibility when investing in the academic missions. The chairpersons of the future should serve as change agents while simultaneously adopting a "servant leadership" model. Chairpersons with executive and team building skills, and business acumen and experience, are more likely to succeed in managing productive and lean departments. Quality of patient care and service delivery enhance the department's effectiveness and credibility and assure access to additional financial resources to subsidize the academic missions. Moreover, the drive for excellence, high performance and growth will fuel financial solvency. Copyright © 2016 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

  19. Comparative cardiovascular physiology: future trends, opportunities and challenges.

    Science.gov (United States)

    Burggren, W W; Christoffels, V M; Crossley, D A; Enok, S; Farrell, A P; Hedrick, M S; Hicks, J W; Jensen, B; Moorman, A F M; Mueller, C A; Skovgaard, N; Taylor, E W; Wang, T

    2014-02-01

    The inaugural Kjell Johansen Lecture in the Zoophysiology Department of Aarhus University (Aarhus, Denmark) afforded the opportunity for a focused workshop comprising comparative cardiovascular physiologists to ponder some of the key unanswered questions in the field. Discussions were centred around three themes. The first considered function of the vertebrate heart in its various forms in extant vertebrates, with particular focus on the role of intracardiac shunts, the trabecular ('spongy') nature of the ventricle in many vertebrates, coronary blood supply and the building plan of the heart as revealed by molecular approaches. The second theme involved the key unanswered questions in the control of the cardiovascular system, emphasizing autonomic control, hypoxic vasoconstriction and developmental plasticity in cardiovascular control. The final theme involved poorly understood aspects of the interaction of the cardiovascular system with the lymphatic, renal and digestive systems. Having posed key questions around these three themes, it is increasingly clear that an abundance of new analytical tools and approaches will allow us to learn much about vertebrate cardiovascular systems in the coming years. © 2013 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.

  20. Computational Prediction of Effector Proteins in Fungi: Opportunities and Challenges

    Directory of Open Access Journals (Sweden)

    Humira eSonah

    2016-02-01

    Full Text Available Effector proteins are mostly secretory proteins that stimulate plant infection by manipulating the host response. Identifying fungal effector proteins and understanding their function is of great importance in efforts to curb losses to plant diseases. Recent advances in high-throughput sequencing technologies have facilitated the availability of several fungal genomes and thousands of transcriptomes. As a result, the growing amount of genomic information has provided great opportunities to identify putative effector proteins in different fungal species. There is little consensus over the annotation and functionality of effector proteins, and mostly small secretory proteins are considered as effector proteins, a concept that tends to overestimate the number of proteins involved in a plant-pathogen interaction. With the characterization of Avr genes, criteria for computational prediction of effector proteins are becoming more efficient. There are hundreds of tools available for the identification of conserved motifs, signature sequences and structural features in the proteins. Many pipelines and online servers, which combine several tools, are made available to perform genome-wide identification of effector proteins. In this review, available tools and pipelines, their strength and limitations for effective identification of fungal effector proteins are discussed. We also present an exhaustive list of classically secreted proteins along with their key conserved motifs found in 12 common plant pathogens (11 fungi and one oomycete through an analytical pipeline.

  1. Opportunities and Challenges for Nutritional Proteomics in Cancer Prevention12

    Science.gov (United States)

    Romagnolo, Donato F.; Milner, John A.

    2012-01-01

    Knowledge gaps persist about the efficacy of cancer prevention strategies based on dietary food components. Adaptations to nutrient supply are executed through tuning of multiple protein networks that include transcription factors, histones, modifying enzymes, translation factors, membrane and nuclear receptors, and secreted proteins. However, the simultaneous quantitative and qualitative measurement of all proteins that regulate cancer processes is not practical using traditional protein methodologies. Proteomics offers an attractive opportunity to fill this knowledge gap and unravel the effects of dietary components on protein networks that impinge on cancer. The articles presented in this supplement are from talks proffered in the “Nutrition Proteomics and Cancer Prevention” session at the American Institute for Cancer Research Annual Research Conference on Food, Nutrition, Physical Activity and Cancer held in Washington, DC on October 21 and 22, 2010. Recent advances in MS technologies suggest that studies in nutrition and cancer prevention may benefit from the adoption of proteomic tools to elucidate the impact on biological processes that govern the transition from normal to malignant phenotype; to identify protein changes that determine both positive and negative responses to food components; to assess how protein networks mediate dose-, time-, and tissue-dependent responses to food components; and, finally, for predicting responders and nonresponders. However, both the limited accessibility to proteomic technologies and research funding appear to be hampering the routine adoption of proteomic tools in nutrition and cancer prevention research. PMID:22649262

  2. Opportunities and challenges for nutritional proteomics in cancer prevention.

    Science.gov (United States)

    Romagnolo, Donato F; Milner, John A

    2012-07-01

    Knowledge gaps persist about the efficacy of cancer prevention strategies based on dietary food components. Adaptations to nutrient supply are executed through tuning of multiple protein networks that include transcription factors, histones, modifying enzymes, translation factors, membrane and nuclear receptors, and secreted proteins. However, the simultaneous quantitative and qualitative measurement of all proteins that regulate cancer processes is not practical using traditional protein methodologies. Proteomics offers an attractive opportunity to fill this knowledge gap and unravel the effects of dietary components on protein networks that impinge on cancer. The articles presented in this supplement are from talks proffered in the "Nutrition Proteomics and Cancer Prevention" session at the American Institute for Cancer Research Annual Research Conference on Food, Nutrition, Physical Activity and Cancer held in Washington, DC on October 21 and 22, 2010. Recent advances in MS technologies suggest that studies in nutrition and cancer prevention may benefit from the adoption of proteomic tools to elucidate the impact on biological processes that govern the transition from normal to malignant phenotype; to identify protein changes that determine both positive and negative responses to food components; to assess how protein networks mediate dose-, time-, and tissue-dependent responses to food components; and, finally, for predicting responders and nonresponders. However, both the limited accessibility to proteomic technologies and research funding appear to be hampering the routine adoption of proteomic tools in nutrition and cancer prevention research.

  3. Opportunities and challenges for the export of U.S. value-added wood products to China

    Science.gov (United States)

    Scott Bowe; Matt Bumgardner; Terry Mace

    2008-01-01

    This report explores some of the opportunities for, and challenges associated with, exporting wood products to China. Five topics are examined: an overview of trends in forestry and forest products in China, export opportunities and challenges for U.S. primary wood producers (Study 1), export opportunities and challenges for U.S. secondary wood producers (Study 2),...

  4. Opportunities and challenges for multicriteria assessment of food system sustainability

    Directory of Open Access Journals (Sweden)

    Hugo F. Alrøe

    2016-03-01

    Full Text Available The focus of the Special Feature on "Multicriteria assessment of food system sustainability" is on the complex challenges of making and communicating overall assessments of food systems sustainability based on multiple and varied criteria. Four papers concern the choice and development of appropriate tools for making multicriteria sustainability assessments that handle built-in methodological conflicts and trade-offs between different assessment objectives. They underscore the value of linking diverse methods and tools, or nesting and stepping their deployment, to help build resilience and sustainability. They conclude that there is no one tool, one framework, or one indicator set that is appropriate for the different purposes and contexts of sustainability assessment. The process of creating the assessment framework also emerges as important: if the key stakeholders are not given a responsible and full role in the development of any assessment tool, it is less likely to be fit for their purpose and they are unlikely to take ownership or have confidence in it. Six other papers reflect on more fundamental considerations of how assessments are based in different scientific perspectives and on the role of values, motivation, and trust in relation to assessments in the development of more sustainable food systems. They recommend a radical break with the tradition of conducting multicriteria assessment from one hegemonic perspective to considering multiple perspectives. Collectively the contributions to this Special Feature identify three main challenges for improved multicriteria assessment of food system sustainability: (i how to balance different types of knowledge to avoid that the most well-known, precise, or easiest to measure dimensions of sustainability gets the most weight; (ii how to expose the values in assessment tools and choices to allow evaluation of how they relate to the ethical principles of sustainable food systems, to societal

  5. Data science and symbolic AI: Synergies, challenges and opportunities

    KAUST Repository

    Hoehndorf, Robert

    2017-06-02

    Symbolic approaches to artificial intelligence represent things within a domain of knowledge through physical symbols, combine symbols into symbol expressions, and manipulate symbols and symbol expressions through inference processes. While a large part of Data Science relies on statistics and applies statistical approaches to artificial intelligence, there is an increasing potential for successfully applying symbolic approaches as well. Symbolic representations and symbolic inference are close to human cognitive representations and therefore comprehensible and interpretable; they are widely used to represent data and metadata, and their specific semantic content must be taken into account for analysis of such information; and human communication largely relies on symbols, making symbolic representations a crucial part in the analysis of natural language. Here we discuss the role symbolic representations and inference can play in Data Science, highlight the research challenges from the perspective of the data scientist, and argue that symbolic methods should become a crucial component of the data scientists’ toolbox.

  6. Physics Education Research efforts to promote diversity: Challenges and opportunities

    Science.gov (United States)

    Brahmia, Suzanne

    2015-04-01

    We begin this talk with a brief description of the gender and ethnic diversity of the physics community. We then discuss several current efforts within Physics Education Research that have the potential to further our understanding of issues surrounding underrepresentation. These efforts include research into (1) the role of community and strategies for developing effective communities; (2) physics identity and self-efficacy; (3) the affordances that students from underrepresented groups bring to physics learning; (4) socioeconomics and its impact on mathematization. One of the challenges to conducting this research is the relatively small proportion of underrepresented minority students in current physics classes, and the small number of women in physics and engineering majors. In collaboration with Stephen Kanim, New Mexico State University.

  7. New Directions for Higher Education: Challenges, Opportunities, and Outcomes

    Science.gov (United States)

    Cleveland-Innes, Marta

    Within the last few decades, pervasive technology and significant social and economic development have forever changed our society. Social and economic change has made it increasingly difficult for higher education to operate in insular ways; attention to changing demographics, global economies, and new social mores is required (Keller 2008). The potential reach of technology seems limitless and has already changed higher education institutions in "the way we organize ourselves, our policies, our culture, what faculty do, the way we work, and those we serve" (Ikenberry 1999, p. 63). Change in higher education to accommodate broader societal changes requires new ways of thinking about economic issues, accountability, technology, and the teaching-learning process. This chapter makes the challenges currently facing higher education explicit. It outlines the leadership traits and behaviors that are moving higher education into a hybrid version of traditional and distance institutions. Six principles of sound strategic planning for creating a new higher education enterprise are reviewed.

  8. Emerging Markets for Renewable Energy Certificates: Opportunities and Challenges

    Energy Technology Data Exchange (ETDEWEB)

    Holt, E.; Bird, L.

    2005-01-01

    Renewable energy certificates (RECs) represent the attributes of electricity generated from renewable energy sources. These attributes are unbundled from the physical electricity, and the two products-the attributes embodied in the certificates and the commodity electricity-may be sold or traded separately. RECs are quickly becoming the currency of renewable energy markets because of their flexibility and the fact that they are not subject to the geographic and physical limitations of commodity electricity. RECs are currently used by utilities and marketers to supply renewable energy products to end-use customers as well as to demonstrate compliance with regulatory requirements, such as renewable energy mandates. The purpose of this report is to describe and analyze the emerging market for renewable energy certificates. It describes how RECs are marketed, examines RECs markets including scope and prices, and identifies and describes the key challenges facing the growth and success of RECs markets.

  9. SAGD produced water recycling: technology challenges and opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Perdicakis, B.; Fulton, C [Water Treatment Technology, Heavy Oil Technology Center, Statoil Canada Limited (Canada)

    2011-07-01

    In Alberta's oil sands, several in situ technologies are used to recover bitumen. These techniques consist of producing and then injecting steam into the reservoir to mobilize the bitumen. These techniques are dependent on the use of water and equipment to produce steam and handling the water thus produced represents a significant investment. The purpose of this paper is to present Statoil's efforts in developing new technologies to address the water issue in SAGD operations. Different collaborative development projects, whose aims are to reduce costs, improve reliability and reduce the environmental footprint through a minimization of makeup water use, are presented. In addition to these programs, Statoil is working on the development of a Water Technology Development Center with the aim of accelerating the implementation of water recycling technologies. This paper highlights the participation of Statoil in several projects to develop innovative technologies which will address SAGD-produced water recycling challenges.

  10. Anaerobic digestion of food waste - Challenges and opportunities.

    Science.gov (United States)

    Xu, Fuqing; Li, Yangyang; Ge, Xumeng; Yang, Liangcheng; Li, Yebo

    2018-01-01

    The disposal of large amounts of food waste has caused significant environmental pollution and financial costs globally. Compared with traditional disposal methods (i.e., landfilling, incineration, and composting), anaerobic digestion (AD) is a promising technology for food waste management, but has not yet been fully applied due to a few technical and social challenges. This paper summarizes the quantity, composition, and methane potential of various types of food waste. Recent research on different strategies to enhance AD of food waste, including co-digestion, addition of micronutrients, control of foaming, and process design, is discussed. It is envisaged that AD of food waste could be combined with an existing AD facility or be integrated with the production of value-added products to reduce costs and increase revenue. Further understanding of the fundamental biological and physicochemical processes in AD is required to improve the technology. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Combination therapy: the next opportunity and challenge of medicine

    Directory of Open Access Journals (Sweden)

    Marincola Francesco M

    2011-07-01

    Full Text Available Abstract From an historical point of view, combination therapy was the basis for the care of important diseases like infection diseases or cancer. Today the "cocktail drug" of the Highly Active Anti Retroviral Therapy (HAART has reduced the death for HIV infection changing the outcome of such disease. Moreover, the combination of different strategies changed the course of transplants (both in haematology and surgical transplant. Different diseases with high social impact including cardiovascular, metabolic (obesity, hypercholesterolaemia and diabetes and autoimmune diseases, have better results with combinations of different drug classes of drugs. After recent successes in the immunotherapy field (Sepuleucel-T, ipilimumab and the new promising small molecule therapies, cancer should be the next challenge for combination strategies.

  12. Challenge and Opportunity: the ALI/III Global Principles Project

    Directory of Open Access Journals (Sweden)

    IF Fletcher

    2008-04-01

    Full Text Available This article deals with an international project to establish the extent to which it is feasible to achieve a worldwide acceptance of the Principles of Cooperation among the NAFTA Countries together with the Guidelines Applicable to Court-to-Court Communications in Cross-Border Cases. This contribution explains the process whereby the American Law Institute and the International Insolvency Institute (1 developed principles of cooperation with regard to cross-border insolvency; (2 established acceptance of these principles in jurisdictions across the world, subject to any necessary local modifications; and (3 obtained the endorsement of leading domestic associations, courts, and other groups in those jurisdictions. This article may contribute to the development the South African cross-border insolvency law. The inclusion of the challenges of harmonisation of private international law is also contributing to current debate.

  13. Distance Learning and Teacher Education in Botswana: Opportunities and Challenges

    Directory of Open Access Journals (Sweden)

    Anne L Sikwibele

    2009-09-01

    Full Text Available This paper reports on a study at Molepolole College of Education (MCE involving teachers and tutors in the Diploma in Primary Education (DPE program by distance mode, an in-service program aimed at upgrading academic and professional qualifications of primary school teachers in Botswana. The study sought to understand the level of access and the challenges faced by teachers and tutors. Data was collected through in-depth interviews, survey, and document analysis. Findings showed that teachers should be enrolled in the program at a younger age, and issues that lead to delays in completion must be addressed. The paper recommends that the Ministry of Education (MOE hire full-time tutors to support teachers at their bases, provide resources for practical subjects, organize workshops to familiarize tutors with appropriate strategies for adult learners, increase the duration of residential sessions, explore the use of alternative instructional technologies, and institute regular customer evaluations.

  14. Deceased organ donation for transplantation: Challenges and opportunities

    Science.gov (United States)

    Girlanda, Raffaele

    2016-01-01

    Organ transplantation saves thousands of lives every year but the shortage of donors is a major limiting factor to increase transplantation rates. To allow more patients to be transplanted before they die on the wait-list an increase in the number of donors is necessary. Patients with devastating irreversible brain injury, if medically suitable, are potential deceased donors and strategies are needed to successfully convert them into actual donors. Multiple steps in the process of deceased organ donation can be targeted to increase the number of organs suitable for transplant. In this review, after describing this process, we discuss current challenges and potential strategies to expand the pool of deceased donors. PMID:27683626

  15. Response to Rift Valley Fever in Tanzania: Challenges and Opportunities.

    Science.gov (United States)

    Fyumagwa, Robert D; Ezekiel, Mangi J; Nyaki, Athanas; Mdaki, Maulid L; Katale, Zablon B; Moshiro, Candida; Keyyu, Julius D

    2011-12-01

    Rift Valley Fever (RVF) is an arthropod borne viral disease affecting livestock (cattle, sheep, goats and camels), wildlife and humans caused by Phlebovirus. The disease occurs in periodic cycles of 4-15 years associated with flooding from unusually high precipitations in many flood-prone habitats. Aedes and Culex spp and other mosquito species are important epidemic vectors. Because of poor living conditions and lack of knowledge on the pathogenesis of RVF, nomadic pastoralists and agro-pastoralists are at high risk of contracting the disease during epidemics. RVF is a professional hazard for health and livestock workers because of poor biosafety measures in routine activities including lack of proper Personal Protective Equipment (PPE). Direct exposure to infected animals can occur during handling and slaughter or through veterinary and obstetric procedures or handling of specimens in laboratory. The episodic nature of the disease creates special challenges for its mitigation and control and many of the epidemics happen when the governments are not prepared and have limited resource to contain the disease at source. Since its first description in 1930s Tanzania has recorded six epidemics, three of which were after independence in 1961. However, the 2007 epidemic was the most notable and wide spread with fatal human cases among pastoralists and agro-pastoralists concurrent with high livestock mortality. Given all the knowledge that exist on the epidemiology of the disease, still the 2006/2007 epidemic occurred when the government of Tanzania was not prepared to contain the disease at source. This paper reviews the epidemiology, reporting and outbreak-investigation, public awareness, preparedness plans and policy as well as challenges for its control in Tanzania.

  16. Coal and clean coal technology: challenges and opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Minchener, Andrew [IEA Clean Coal Centre, London (United Kingdom)

    2013-07-01

    Globally, there is a growing concern about fuel diversity and security of supply, particularly with regard to oil and natural gas. In contrast, coal is available from a much wider range of sources and has greater price stability. Consequently, coal use is increasing rapidly, and by 2030 may well reach a level of more than 4,500 Mtoe, corresponding to close to a doubling of current levels. However, at the same time, tightening regulations will require better solutions for achieving environmental compliance, for which coal has a number of key issues to address. Most of the coal will be used in the power generation sector. Consequently, the key research challenges are to develop and deploy methods by which coal can be used cleanly, efficiently, and in a sustainable way. These include improvements to existing coal utilisation technologies, particularly to improve operational flexibility and availability, while reducing energy use through higher efficiencies. There is an increasing need to ensure improved emissions control, with the emphasis on achieving ever-lower emissions of particulates, SO{sub 2} and NO{sub x} while also introducing control of trace species, particularly mercury. Alongside this, a key challenge is the integration of techniques that can capture CO{sub 2} then transport and store it within secure geological formations, thereby resulting in near zero emissions of CO{sub 2}. From a power plant perspective, the need is to achieve such integration while minimising any adverse impact on power plant efficiency, performance of existing emissions control systems, operational flexibility and availability. At the same time, means to minimize the additional costs associated with such technology must be established.

  17. Oral rabies vaccination in north america: opportunities, complexities, and challenges.

    Directory of Open Access Journals (Sweden)

    Dennis Slate

    Full Text Available Steps to facilitate inter-jurisdictional collaboration nationally and continentally have been critical for implementing and conducting coordinated wildlife rabies management programs that rely heavily on oral rabies vaccination (ORV. Formation of a national rabies management team has been pivotal for coordinated ORV programs in the United States of America. The signing of the North American Rabies Management Plan extended a collaborative framework for coordination of surveillance, control, and research in border areas among Canada, Mexico, and the US. Advances in enhanced surveillance have facilitated sampling of greater scope and intensity near ORV zones for improved rabies management decision-making in real time. The value of enhanced surveillance as a complement to public health surveillance was best illustrated in Ohio during 2007, where 19 rabies cases were detected that were critical for the formulation of focused contingency actions for controlling rabies in this strategically key area. Diverse complexities and challenges are commonplace when applying ORV to control rabies in wild meso-carnivores. Nevertheless, intervention has resulted in notable successes, including the elimination of an arctic fox (Vulpes lagopus rabies virus variant in most of southern Ontario, Canada, with ancillary benefits of elimination extending into Quebec and the northeastern US. Progress continues with ORV toward preventing the spread and working toward elimination of a unique variant of gray fox (Urocyon cinereoargenteus rabies in west central Texas. Elimination of rabies in coyotes (Canis latrans through ORV contributed to the US being declared free of canine rabies in 2007. Raccoon (Procyon lotor rabies control continues to present the greatest challenges among meso-carnivore rabies reservoirs, yet to date intervention has prevented this variant from gaining a broad geographic foothold beyond ORV zones designed to prevent its spread from the eastern US

  18. Challenges in inhaled product development and opportunities for open innovation.

    Science.gov (United States)

    Forbes, Ben; Asgharian, Bahman; Dailey, Lea Ann; Ferguson, Douglas; Gerde, Per; Gumbleton, Mark; Gustavsson, Lena; Hardy, Colin; Hassall, David; Jones, Rhys; Lock, Ruth; Maas, Janet; McGovern, Tim; Pitcairn, Gary R; Somers, Graham; Wolff, Ron K

    2011-01-01

    Dosimetry, safety and the efficacy of drugs in the lungs are critical factors in the development of inhaled medicines. This article considers the challenges in each of these areas with reference to current industry practices for developing inhaled products, and suggests collaborative scientific approaches to address these challenges. The portfolio of molecules requiring delivery by inhalation has expanded rapidly to include novel drugs for lung disease, combination therapies, biopharmaceuticals and candidates for systemic delivery via the lung. For these drugs to be developed as inhaled medicines, a better understanding of their fate in the lungs and how this might be modified is required. Harmonized approaches based on 'best practice' are advocated for dosimetry and safety studies; this would provide coherent data to help product developers and regulatory agencies differentiate new inhaled drug products. To date, there are limited reports describing full temporal relationships between pharmacokinetic (PK) and pharmacodynamic (PD) measurements. A better understanding of pulmonary PK and PK/PD relationships would help mitigate the risk of not engaging successfully or persistently with the drug target as well as identifying the potential for drug accumulation in the lung or excessive systemic exposure. Recommendations are made for (i) better industry-academia-regulatory co-operation, (ii) sharing of pre-competitive data, and (iii) open innovation through collaborative research in key topics such as lung deposition, drug solubility and dissolution in lung fluid, adaptive responses in safety studies, biomarker development and validation, the role of transporters in pulmonary drug disposition, target localisation within the lung and the determinants of local efficacy following inhaled drug administration. Copyright © 2010 Elsevier B.V. All rights reserved.

  19. Induced pluripotent stem cells: Challenges and opportunities for cancer immunotherapy

    Directory of Open Access Journals (Sweden)

    Patty eSachamitr

    2014-04-01

    Full Text Available Despite recent advances in cancer treatment over the past 30 years, therapeutic options remain limited and do not always offer a cure for malignancy. Given that tumour associated antigens (TAA are, by definition, self-proteins, the need to productively engage autoreactive T cells remains at the heart of strategies for cancer immunotherapy. These have traditionally focussed on the administration of autologous monocyte-derived dendritic cells (moDC pulsed with TAA, or the ex vivo expansion and adoptive transfer of tumour infiltrating lymphocytes (TIL as a source of TAA-specific cytotoxic T cells (CTL. Although such approaches have shown some efficacy, success has been limited by the poor capacity of moDC to cross-present exogenous TAA to the CD8+ T cell repertoire and the potential for exhaustion of CTL expanded ex vivo. Recent advances in induced pluripotency offer opportunities to generate patient-specific stem cell lines with the potential to differentiate in vitro into cell types whose properties may help address these issues. Here we review recent success in the differentiation of NK cells from human induced pluripotent stem (iPS cells as well as minor subsets of DC with therapeutic potential, including CD141+XCR1+ DC, capable of cross-presenting TAA to naïve CD8+ T cells. Furthermore, we review recent progress in the use of TIL as the starting material for the derivation of iPSC lines, thereby capturing their antigen specificity in a self-renewing stem cell line, from which potentially unlimited numbers of naïve TAA-specific T cells may be differentiated, free of the risks of exhaustion.

  20. Targeting JAK kinase in solid tumors: emerging opportunities and challenges.

    Science.gov (United States)

    Buchert, M; Burns, C J; Ernst, M

    2016-02-25

    Various human malignancies are characterized by excessive activation of the Janus family of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and STAT5. In the majority of solid tumors, this occurs in response to increased abundance of inflammatory cytokines in the tumor microenvironment prominently produced by infiltrating innate immune cells. Many of these cytokines share common receptor subunits and belong to the interleukin (IL)-6/IL-11, IL-10/IL-22 and IL-12/IL-23 families. Therapeutic inhibition of the JAK/STAT3 pathway potentially offers considerable benefit owing to the capacity of JAK/STAT3 signaling to promote cancer hallmarks in the tumor and its environment, including proliferation, survival, angiogenesis, tumor metabolism while suppressing antitumor immunity. This is further emphasized by the current successful clinical applications of JAK-specific small molecule inhibitors for the treatment of inflammatory disorders and hematopoietic malignancies. Here we review current preclinical applications for JAK inhibitors for the treatment of solid cancers in mice, with a focus on the most common malignancies emanating from oncogenic transformation of the epithelial mucosa in the stomach and colon. Emerging data with small molecule JAK-specific adenosine triphosphate-binding analogs corroborate genetic findings and suggest that interference with the JAK/STAT3 pathway may suppress the growth of the most common forms of sporadic colon cancers that arise from mutations of the APC tumor suppressor gene. Likewise inhibition of cytokine-dependent activation of the JAK/STAT3 pathway may also afford orthogonal treatment opportunities for other oncogene-addicted cancer cells that have gained drug resistance.

  1. Opportunities and Challenges for Personal Heat Exposure Research.

    Science.gov (United States)

    Kuras, Evan R; Richardson, Molly B; Calkins, Miriam M; Ebi, Kristie L; Hess, Jeremy J; Kintziger, Kristina W; Jagger, Meredith A; Middel, Ariane; Scott, Anna A; Spector, June T; Uejio, Christopher K; Vanos, Jennifer K; Zaitchik, Benjamin F; Gohlke, Julia M; Hondula, David M

    2017-08-01

    Environmental heat exposure is a public health concern. The impacts of environmental heat on mortality and morbidity at the population scale are well documented, but little is known about specific exposures that individuals experience. The first objective of this work was to catalyze discussion of the role of personal heat exposure information in research and risk assessment. The second objective was to provide guidance regarding the operationalization of personal heat exposure research methods. We define personal heat exposure as realized contact between a person and an indoor or outdoor environment that poses a risk of increases in body core temperature and/or perceived discomfort. Personal heat exposure can be measured directly with wearable monitors or estimated indirectly through the combination of time-activity and meteorological data sets. Complementary information to understand individual-scale drivers of behavior, susceptibility, and health and comfort outcomes can be collected from additional monitors, surveys, interviews, ethnographic approaches, and additional social and health data sets. Personal exposure research can help reveal the extent of exposure misclassification that occurs when individual exposure to heat is estimated using ambient temperature measured at fixed sites and can provide insights for epidemiological risk assessment concerning extreme heat. Personal heat exposure research provides more valid and precise insights into how often people encounter heat conditions and when, where, to whom, and why these encounters occur. Published literature on personal heat exposure is limited to date, but existing studies point to opportunities to inform public health practice regarding extreme heat, particularly where fine-scale precision is needed to reduce health consequences of heat exposure. https://doi.org/10.1289/EHP556.

  2. Research Challenges and Opportunities for Clinically Oriented Academic Radiology Departments.

    Science.gov (United States)

    Decker, Summer J; Grajo, Joseph R; Hazelton, Todd R; Hoang, Kimberly N; McDonald, Jennifer S; Otero, Hansel J; Patel, Midhir J; Prober, Allen S; Retrouvey, Michele; Rosenkrantz, Andrew B; Roth, Christopher G; Ward, Robert J

    2016-01-01

    Between 2004 and 2012, US funding for the biomedical sciences decreased to historic lows. Health-related research was crippled by receiving only 1/20th of overall federal scientific funding. Despite the current funding climate, there is increased pressure on academic radiology programs to establish productive research programs. Whereas larger programs have resources that can be utilized at their institutions, small to medium-sized programs often struggle with lack of infrastructure and support. To address these concerns, the Association of University Radiologists' Radiology Research Alliance developed a task force to explore any untapped research productivity potential in these smaller radiology departments. We conducted an online survey of faculty at smaller clinically funded programs and found that while they were interested in doing research and felt it was important to the success of the field, barriers such as lack of resources and time were proving difficult to overcome. One potential solution proposed by this task force is a collaborative structured research model in which multiple participants from multiple institutions come together in well-defined roles that allow for an equitable distribution of research tasks and pooling of resources and expertise. Under this model, smaller programs will have an opportunity to share their unique perspective on how to address research topics and make a measureable impact on the field of radiology as a whole. Through a health services focus, projects are more likely to succeed in the context of limited funding and infrastructure while simultaneously providing value to the field. Copyright © 2016 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

  3. Molecular Dynamics Simulations, Challenges and Opportunities: A Biologist's Prospective.

    Science.gov (United States)

    Kumari, Indu; Sandhu, Padmani; Ahmed, Mushtaq; Akhter, Yusuf

    2017-08-30

    Molecular dynamics (MD) is a computational technique which is used to study biomolecules in virtual environment. Each of the constituent atoms represents a particle and hence the biomolecule embodies a multi-particle mechanical system analyzed within a simulation box during MD analysis. The potential energies of the atoms are explained by a mathematical expression consisting of different forces and space parameters. There are various software and force fields that have been developed for MD studies of the biomolecules. MD analysis has unravelled the various biological mechanisms (protein folding/unfolding, protein-small molecule interactions, protein-protein interactions, DNA/RNA-protein interactions, proteins embedded in membrane, lipid-lipid interactions, drug transport etc.) operating at the atomic and molecular levels. However, there are still some parameters including torsions in amino acids, carbohydrates (whose structure is extended and not well defined like that of proteins) and single stranded nucleic acids for which the force fields need further improvement, although there are several workers putting in constant efforts in these directions. The existing force fields are not efficient for studying the crowded environment inside the cells, since these interactions involve multiple factors in real time. Therefore, the improved force fields may provide the opportunities for their wider applications on the complex biosystems in diverse cellular conditions. In conclusion, the intervention of MD in the basic sciences involving interdisciplinary approaches will be helpful for understanding many fundamental biological and physiological processes at the molecular levels that may be further applied in various fields including biotechnology, fisheries, sustainable agriculture and biomedical research. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  4. Earthquake Early Warning and Public Policy: Opportunities and Challenges

    Science.gov (United States)

    Goltz, J. D.; Bourque, L.; Tierney, K.; Riopelle, D.; Shoaf, K.; Seligson, H.; Flores, P.

    2003-12-01

    Development of an earthquake early warning capability and pilot project were objectives of TriNet, a 5-year (1997-2001) FEMA-funded project to develop a state-of-the-art digital seismic network in southern California. In parallel with research to assemble a protocol for rapid analysis of earthquake data and transmission of a signal by TriNet scientists and engineers, the public policy, communication and educational issues inherent in implementation of an earthquake early warning system were addressed by TriNet's outreach component. These studies included: 1) a survey that identified potential users of an earthquake early warning system and how an earthquake early warning might be used in responding to an event, 2) a review of warning systems and communication issues associated with other natural hazards and how lessons learned might be applied to an alerting system for earthquakes, 3) an analysis of organization, management and public policy issues that must be addressed if a broad-based warning system is to be developed and 4) a plan to provide earthquake early warnings to a small number of organizations in southern California as an experimental prototype. These studies provided needed insights into the social and cultural environment in which this new technology will be introduced, an environment with opportunities to enhance our response capabilities but also an environment with significant barriers to overcome to achieve a system that can be sustained and supported. In this presentation we will address the main public policy issues that were subjects of analysis in these studies. They include a discussion of the possible division of functions among organizations likely to be the principle partners in the management of an earthquake early warning system. Drawing on lessons learned from warning systems for other hazards, we will review the potential impacts of false alarms and missed events on warning system credibility, the acceptability of fully automated

  5. Intercultural and Interlinguistical Mediation in the Healthcare System: The Challenge of Conflict Management

    Directory of Open Access Journals (Sweden)

    Federico Farini

    2008-09-01

    Full Text Available Nowadays, young women and their children are the most important migrant users of health-care services. In particular, these people may encounter different cultural constructions of health, disease, therapy, and motherhood. The observed difficulties in intercultural communication encourage healthcare systems to promote mediation. Mediation consists of the intervention of a third person, who promotes reciprocal understanding and acceptance between participants. The research presented in this article focuses on the intercultural communication that is produced in these services between health-care personnel and migrant patients. To achieve this goal, the research aims at integrating different theoretical and methodological approaches: conversation analysis, in order to observe the interaction between healthcare personnel and patients, pointing out the cues of the participants’ turn-taking sequences; analysis of the cultural presuppositions of the healthcare system as a communication system with a specific function in society, by highlighting contextualization cues, that is, cultural presuppositions that steer the interaction system, which result from the wider social context and are cues of the cultural identities that characterize it. It was observed that the patients in most cases have very few opportunities to answer the physicians’ questions or to pose questions or doubts. Substituting the patients as the main participants in interactions, the mediator never refuses the physicians’ indications, never expresses doubts, and never asks the patients if they have some reason to doubt or refuse. In these cases, interlinguistic and intercultural mediation de-emphasizes the importance of the larger social context, of the durability of relationships between the parties, and of their social and political recognition.

  6. Psychiatric rehabilitation in Latin America: challenges and opportunities.

    Science.gov (United States)

    Uribe-Restrepo, J M; Escobar, M L; Cubillos, L

    2017-06-01

    Comprehensive psychiatric rehabilitation programs in Latin America have been designed across several countries in the region without yet achieving full implementation. Facing an increasing burden of disease due to mental disorders, including alcohol and substance use disorders, the region has responded unevenly to the challenge. Moreover, low priority for mental health in national policies and insufficient funding for mental health services are common barriers for the much-needed mental health services reforms. Reestablishing a primary care community-based model of care has been a shared aspiration for most countries during the last two decades. Comprehensive models of psychiatric rehabilitation developed predominantly in high-income countries need to be culturally adapted to local contexts, while strengthening health systems research will provide evidence on the efficiency of locally designed interventions and on the critical milestones to succeed in the scaling up strategies. Increasing participation of patients and their families in the mental health delivery system is another key factor in order to ensure comprehensive patient-centred psychosocial rehabilitation programs in Latin America.

  7. Challenges And Opportunities For The Future Of Icampuses

    Directory of Open Access Journals (Sweden)

    Andrew Thomas

    2013-01-01

    Full Text Available Meeting the educational needs of students currently requires moving towardcollaborative electronic and mobile learning systems that parallel the vision ofWeb 2.0. However, factors such as data freedom, brokerage, interconnectivityand the Internet of Things add to a vision for Web 3.0 that will require con-sideration in the development of future campus-based, distance and vocationalstudy. So, education can, in future, be expected to require deeper technologicalconnections between students and learning environments, based on significantuse of sensors, mobile devices, cloud computing and rich-media visualization.Therefore, we discuss challenges associated with such a futuristic campus con-text, including how learning materials and environments may be enriched byit. As an additional novel element the potential for much of that enrichmentto be realized through development by students, within the curriculum, is alsoconsidered. We will conclude that much of the technology required to embracethe vision of Web 3.0 in education already exists, but that further research inkey areas is required for the concept to achieve its full potential.

  8. Extra-terrestrial construction processes - Advancements, opportunities and challenges

    Science.gov (United States)

    Lim, Sungwoo; Prabhu, Vibha Levin; Anand, Mahesh; Taylor, Lawrence A.

    2017-10-01

    Government space agencies, including NASA and ESA, are conducting preliminary studies on building alternative space-habitat systems for deep-space exploration. Such studies include development of advanced technologies for planetary surface exploration, including an in-depth understanding of the use of local resources. Currently, NASA plans to land humans on Mars in the 2030s. Similarly, other space agencies from Europe (ESA), Canada (CSA), Russia (Roscosmos), India (ISRO), Japan (JAXA) and China (CNSA) have already initiated or announced their plans for launching a series of lunar missions over the next decade, ranging from orbiters, landers and rovers for extended stays on the lunar surface. As the Space Odyssey is one of humanity's oldest dreams, there has been a series of research works for establishing temporary or permanent settlement on other planetary bodies, including the Moon and Mars. This paper reviews current projects developing extra-terrestrial construction, broadly categorised as: (i) ISRU-based construction materials; (ii) fabrication methods; and (iii) construction processes. It also discusses four categories of challenges to developing an appropriate construction process: (i) lunar simulants; (ii) material fabrication and curing; (iii) microwave-sintering based fabrication; and (iv) fully autonomous and scaled-up construction processes.

  9. Immunology of Bats and Their Viruses: Challenges and Opportunities

    Directory of Open Access Journals (Sweden)

    Tony Schountz

    2014-12-01

    Full Text Available Bats are reservoir hosts of several high-impact viruses that cause significant human diseases, including Nipah virus, Marburg virus and rabies virus. They also harbor many other viruses that are thought to have caused disease in humans after spillover into intermediate hosts, including SARS and MERS coronaviruses. As is usual with reservoir hosts, these viruses apparently cause little or no pathology in bats. Despite the importance of bats as reservoir hosts of zoonotic and potentially zoonotic agents, virtually nothing is known about the host/virus relationships; principally because few colonies of bats are available for experimental infections, a lack of reagents, methods and expertise for studying bat antiviral responses and immunology, and the difficulty of conducting meaningful field work. These challenges can be addressed, in part, with new technologies that are species-independent that can provide insight into the interactions of bats and viruses, which should clarify how the viruses persist in nature, and what risk factors might facilitate transmission to humans and livestock.

  10. Assessing and Managing Natural Resource Damages: Continuing Challenges and Opportunities.

    Science.gov (United States)

    Barnthouse, Lawrence W; Stahl, Ralph G

    2017-05-01

    In a 2002 paper, we discussed the technical challenges associated with quantifying natural resource injuries, service losses and damages, and suggested some actions that might help to overcome them. An important suggestion was to consider using some of the approaches in ecological risk assessment to help evaluate potential natural resource injuries, and ultimately in some cases to help translate those injuries into natural resource service loss. This was based on the observation that ecological risk assessment and natural resource damage assessments use much of the same types of data, but at that time the experience base with ecological risk assessment was greater than for natural resource damage assessments. We also discussed some of the issues in applying the then current Department of Interior natural resource damage assessments regulations. Since our 2002 publication the scientific literature, relevant regulations, the global context and more have changed. In the current paper we focus on the technical and regulatory changes in natural resource damage assessments practice since 2002, and use recent reports and publications to illustrate those changes and identify new directions in natural resource damage assessments.

  11. Vestibular Migraine: Clinical Challenges and Opportunities for Multidisciplinarity

    Directory of Open Access Journals (Sweden)

    Isabel Luzeiro

    2016-01-01

    Full Text Available Migraine and vertigo are two very prevalent conditions in general population. The coexistence of both in the same subject is a significant clinical challenge, since it is not always possible to understand whether they are causally related or associated by chance, requiring different diagnostic and therapeutic approaches. In this review we analyze and summarize the actual knowledge about vestibular migraine (VM, focusing on the new concepts proposed by the International Classification of Headache Disorders 3-beta and by the Bárány Society and also addressing the former concepts, which are still present in clinical practice. We conclude that clinical studies using a multidisciplinary approach are crucial in this field, since different specialists observe the same pathology with different eyes. Clinical presentation of VM is variable in what concerns vestibular symptoms temporal relation with migraine headache, as well as in their accompanying manifestations. Biomarkers, either genomics or functional, and molecular imaging techniques will be helpful to clarify many aspects of the complexity of this entity, helping to define to what extent can VM be considered a separate and independent clinical entity.

  12. Women and health consequences of natural disasters: Challenge or opportunity?

    Science.gov (United States)

    Sohrabizadeh, Sanaz; Tourani PhD, Sogand; Khankeh, Hamid Reza

    2016-01-01

    Disasters do not affect people equally; the impact of disasters on the lives of women is different from other groups of a community. Women's fundamental rights to health and safety are violated after disasters. The authors of this study aimed to explore various factors of women's health with reference to previous natural disasters in Iran. A qualitative approach using in-depth unstructured interviews and field observations was employed to explore women's health factors in the affected regions. A total of 22 participants affected by disasters, as well as key informants, were interviewed applying the purposeful sampling method. Data were collected in 2014 in three provinces, including East Azerbaijan, Bushehr, and Mazandaran. A content analysis using the Graneheim approach was performed for analyzing the transcribed interviews. Two themes and four categories were extracted from the data. The themes that emerged included psycho-physical effects and women's health status. Physical and psycho-emotional effects and reproductive and environmental health effects were the four emergent categories. The findings implied that managing women's health challenges may result in reducing the distressing effects of disaster. These findings support identification and application of the mechanisms by which women's well-being in physical, mental, reproductive, and environmental aspects can be protected after disasters.

  13. Assessing and Managing Natural Resource Damages: Continuing Challenges and Opportunities

    Science.gov (United States)

    Barnthouse, Lawrence W.; Stahl, Ralph G.

    2017-05-01

    In a 2002 paper, we discussed the technical challenges associated with quantifying natural resource injuries, service losses and damages, and suggested some actions that might help to overcome them. An important suggestion was to consider using some of the approaches in ecological risk assessment to help evaluate potential natural resource injuries, and ultimately in some cases to help translate those injuries into natural resource service loss. This was based on the observation that ecological risk assessment and natural resource damage assessments use much of the same types of data, but at that time the experience base with ecological risk assessment was greater than for natural resource damage assessments. We also discussed some of the issues in applying the then current Department of Interior natural resource damage assessments regulations. Since our 2002 publication the scientific literature, relevant regulations, the global context and more have changed. In the current paper we focus on the technical and regulatory changes in natural resource damage assessments practice since 2002, and use recent reports and publications to illustrate those changes and identify new directions in natural resource damage assessments.

  14. Vestibular Migraine: Clinical Challenges and Opportunities for Multidisciplinarity

    Science.gov (United States)

    Luís, Leonel; Gonçalves, Freire; Pavão Martins, Isabel

    2016-01-01

    Migraine and vertigo are two very prevalent conditions in general population. The coexistence of both in the same subject is a significant clinical challenge, since it is not always possible to understand whether they are causally related or associated by chance, requiring different diagnostic and therapeutic approaches. In this review we analyze and summarize the actual knowledge about vestibular migraine (VM), focusing on the new concepts proposed by the International Classification of Headache Disorders 3-beta and by the Bárány Society and also addressing the former concepts, which are still present in clinical practice. We conclude that clinical studies using a multidisciplinary approach are crucial in this field, since different specialists observe the same pathology with different eyes. Clinical presentation of VM is variable in what concerns vestibular symptoms temporal relation with migraine headache, as well as in their accompanying manifestations. Biomarkers, either genomics or functional, and molecular imaging techniques will be helpful to clarify many aspects of the complexity of this entity, helping to define to what extent can VM be considered a separate and independent clinical entity. PMID:28082766

  15. Bioconversion of natural gas to liquid fuel: Opportunities and challenges

    Energy Technology Data Exchange (ETDEWEB)

    Fei, Q; Guarnieri, MT; Tao, L; Laurens, LML; Dowe, N; Pienkos, PT

    2014-05-01

    Natural gas is a mixture of low molecular weight hydrocarbon gases that can be generated from either fossil or anthropogenic resources. Although natural gas is used as a transportation fuel, constraints in storage, relatively low energy content (MJ/L), and delivery have limited widespread adoption. Advanced utilization of natural gas has been explored for biofuel production by microorganisms. In recent years, the aerobic bioconversion of natural gas (or primarily the methane content of natural gas) into liquid fuels (Bio-GTL) by biocatalysts (methanotrophs) has gained increasing attention as a promising alternative for drop-in biofuel production. Methanotrophic bacteria are capable of converting methane into microbial lipids, which can in turn be converted into renewable diesel via a hydrotreating process. In this paper, biodiversity, catalytic properties and key enzymes and pathways of these microbes are summarized. Bioprocess technologies are discussed based upon existing literature, including cultivation conditions, fermentation modes, bioreactor design, and lipid extraction and upgrading. This review also outlines the potential of Bio-GTL using methane as an alternative carbon source as well as the major challenges and future research needs of microbial lipid accumulation derived from methane, key performance index, and techno-economic analysis. An analysis of raw material costs suggests that methane-derived diesel fuel has the potential to be competitive with petroleum-derived diesel. (C) 2014 The Authors. Published by Elsevier Inc.

  16. Bioconversion of Natural Gas to Liquid Fuel. Opportunities and Challenges

    Energy Technology Data Exchange (ETDEWEB)

    Fei, Qiang [National Renewable Energy Lab. (NREL), Golden, CO (United States); Guarnieri, Michael T. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Tao, Ling [National Renewable Energy Lab. (NREL), Golden, CO (United States); Laurens, Lieve M. L. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Dowe, Nancy [National Renewable Energy Lab. (NREL), Golden, CO (United States); Pienkos, Philip T. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2014-05-01

    Natural gas is a mixture of low molecular weight hydrocarbon gases that can be generated from either fossil or anthropogenic resources. Although natural gas is used as a transportation fuel, constraints in storage, relatively low energy content (MJ/L), and delivery have limited widespread adoption. Advanced utilization of natural gas has been explored for biofuel production by microorganisms. In recent years, the aerobic bioconversion of natural gas (or primarily the methane content of natural gas) into liquid fuels (Bio-GTL) by biocatalysts (methanotrophs) has gained increasing attention as a promising alternative for drop-in biofuel production. Moreover, methanotrophic bacteria are capable of converting methane into microbial lipids, which can in turn be converted into renewable diesel via a hydrotreating process. In this paper, biodiversity, catalytic properties and key enzymes and pathways of these microbes are summarized. Bioprocess technologies are discussed based upon existing literature, including cultivation conditions, fermentation modes, bioreactor design, and lipid extraction and upgrading. Our review also outlines the potential of Bio-GTL using methane as an alternative carbon source as well as the major challenges and future research needs of microbial lipid accumulation derived from methane, key performance index, and techno-economic analysis. An analysis of raw material costs suggests that methane-derived diesel fuel has the potential to be competitive with petroleum-derived diesel.

  17. Bioconversion of natural gas to liquid fuel: opportunities and challenges.

    Science.gov (United States)

    Fei, Qiang; Guarnieri, Michael T; Tao, Ling; Laurens, Lieve M L; Dowe, Nancy; Pienkos, Philip T

    2014-01-01

    Natural gas is a mixture of low molecular weight hydrocarbon gases that can be generated from either fossil or anthropogenic resources. Although natural gas is used as a transportation fuel, constraints in storage, relatively low energy content (MJ/L), and delivery have limited widespread adoption. Advanced utilization of natural gas has been explored for biofuel production by microorganisms. In recent years, the aerobic bioconversion of natural gas (or primarily the methane content of natural gas) into liquid fuels (Bio-GTL) by biocatalysts (methanotrophs) has gained increasing attention as a promising alternative for drop-in biofuel production. Methanotrophic bacteria are capable of converting methane into microbial lipids, which can in turn be converted into renewable diesel via a hydrotreating process. In this paper, biodiversity, catalytic properties and key enzymes and pathways of these microbes are summarized. Bioprocess technologies are discussed based upon existing literature, including cultivation conditions, fermentation modes, bioreactor design, and lipid extraction and upgrading. This review also outlines the potential of Bio-GTL using methane as an alternative carbon source as well as the major challenges and future research needs of microbial lipid accumulation derived from methane, key performance index, and techno-economic analysis. An analysis of raw material costs suggests that methane-derived diesel fuel has the potential to be competitive with petroleum-derived diesel. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  18. Germanium Based Field-Effect Transistors: Challenges and Opportunities

    Directory of Open Access Journals (Sweden)

    Patrick S. Goley

    2014-03-01

    Full Text Available The performance of strained silicon (Si as the channel material for today’s metal-oxide-semiconductor field-effect transistors may be reaching a plateau. New channel materials with high carrier mobility are being investigated as alternatives and have the potential to unlock an era of ultra-low-power and high-speed microelectronic devices. Chief among these new materials is germanium (Ge. This work reviews the two major remaining challenges that Ge based devices must overcome if they are to replace Si as the channel material, namely, heterogeneous integration of Ge on Si substrates, and developing a suitable gate stack. Next, Ge is compared to compound III-V materials in terms of p-channel device performance to review how it became the first choice for PMOS devices. Different Ge device architectures, including surface channel and quantum well configurations, are reviewed. Finally, state-of-the-art Ge device results and future prospects are also discussed.

  19. Sex Control in Fish: Approaches, Challenges and Opportunities for Aquaculture

    Directory of Open Access Journals (Sweden)

    Alyssa M. Budd

    2015-05-01

    Full Text Available At present, aquaculture is the fastest growing sector of animal food production and holds great potential as a sustainable solution for world food security. The ability to control sex is one of the most important factors for the commercialisation and efficient propagation of fish species, due to influences on reproduction, growth and product quality. Accordingly, there is a large body of research that targets sexual development in commercially important species in an attempt to understand and control fish sex and reproductive function. In this review, we provide an introduction to sex determination and differentiation in fish, including the genetic, epigenetic and environmental factors that can influence fish sex ratios. We also summarise the major approaches used to control sex in fish and discuss their application in commercially important species. Specifically, we discuss the use of exogenous steroid hormones, chromosome ploidy, environmental manipulations, sex-linked genetic markers, selection for altered sex ratios, and transgenics and comment on the challenges associated with controlling sex in a commercial environment.

  20. Marketing + internet = e-commerce: opportunities and challenges

    Directory of Open Access Journals (Sweden)

    Pedro Barrientos Felipa

    2017-03-01

    Full Text Available Despite only a short time passing since the Internet started to be used, it is clear today that it is producing significant changes in business. As this article highlights, this is only the beginning, since, for example, changes are being introduced to the way of life at home and at the office. For this reason, studies will continue to be carried out in order to better understand the impact and role of the Internet on the process of globalization. Currently, there is a new reality and many activities are replaced, including marketing, which now requires a new type of professionals and a new way of doing things. Management faces a challenge regarding information: what previously was scarce is now abundant and unordered. The future of business depends on the extent companies take advantage of the Internet. In this line, the article seeks to present the contribution of the Internet to the business sector and, consequently, to national economy. Similarly, it aims to explore the qualities that make the Internet attractive for business strategy, especially the benefits that companies must generate, not only expect. Finally, it seeks to expose the actions that companies must take, by making the most of the Internet, to improve cost productivity and to position their product or to strengthen it, while generating greater profits for the shareholders.

  1. Neurobiologically-based treatments in Rett syndrome: opportunities and challenges

    Science.gov (United States)

    Kaufmann, Walter E.; Stallworth, Jennifer L.; Everman, David B.; Skinner, Steven A.

    2016-01-01

    ABSTRACT Introduction: Rett syndrome (RTT) is an X-linked neurodevelopmental disorder that primarily affects females, typically resulting in a period of developmental regression in early childhood followed by stabilization and severe chronic cognitive, behavioral, and physical disability. No known treatment exists beyond symptomatic management, and while insights into the genetic cause, pathophysiology, neurobiology, and natural history of RTT have been gained, many challenges remain. Areas covered: Based on a comprehensive survey of the primary literature on RTT, this article describes and comments upon the general and unique features of the disorder, genetic and neurobiological bases of drug development, and the history of clinical trials in RTT, with an emphasis on drug trial design, outcome measures, and implementation. Expert opinion: Neurobiologically based drug trials are the ultimate goal in RTT, and due to the complexity and global nature of the disorder, drugs targeting both general mechanisms (e.g., growth factors) and specific systems (e.g., glutamate modulators) could be effective. Trial design should optimize data on safety and efficacy, but selection of outcome measures with adequate measurement properties, as well as innovative strategies, such as those enhancing synaptic plasticity and use of biomarkers, are essential for progress in RTT and other neurodevelopmental disorders. PMID:28163986

  2. Addressing psychiatric education in Latin America: challenges and opportunities.

    Science.gov (United States)

    Fahrer, Rodolfo; Jorge, Miguel R; Ruiz, Pedro

    2010-01-01

    This article is about the psychiatric educational components in the field of psychiatry. Currently the training and educational objectives focus on five major areas: undergraduate education (medical students); graduate education (psychiatric residents); psychiatric education for primary care physicians, as well as physicians in other medical specializations (psychosomatic training); public health and public education at large, and patient and family education, and the promotion of 'mental health' at a community level. Given the strong globalization process observed in all regions of the world in the past two or three decades, it is very important for Latin America to constantly review and update its psychiatric and behavioural sciences curriculum across all medical institutions and universities of the continent. New methods of teaching and novel approaches to education in the field of psychiatry are currently based on models that are also in use in other parts of the world, especially in the USA. Boards of certification for psychiatrists are being implemented all over the continent. Sound certification guarantees that the professional has followed and passed an educational training plan to make him/her qualified to start practising the profession. The future of psychiatric training will be closely bound to the future of the practice of psychiatry, and will have to get ahead of the challenges the specialism will face during the next decades.

  3. Computational Research Challenges and Opportunities for the Optimization of Fossil Energy Power Generation System

    Energy Technology Data Exchange (ETDEWEB)

    Zitney, S.E.

    2007-06-01

    Emerging fossil energy power generation systems must operate with unprecedented efficiency and near-zero emissions, while optimizing profitably amid cost fluctuations for raw materials, finished products, and energy. To help address these challenges, the fossil energy industry will have to rely increasingly on the use advanced computational tools for modeling and simulating complex process systems. In this paper, we present the computational research challenges and opportunities for the optimization of fossil energy power generation systems across the plant lifecycle from process synthesis and design to plant operations. We also look beyond the plant gates to discuss research challenges and opportunities for enterprise-wide optimization, including planning, scheduling, and supply chain technologies.

  4. Genome editing for crop improvement: Challenges and opportunities.

    Science.gov (United States)

    Abdallah, Naglaa A; Prakash, Channapatna S; McHughen, Alan G

    2015-01-01

    Genome or gene editing includes several new techniques to help scientists precisely modify genome sequences. The techniques also enables us to alter the regulation of gene expression patterns in a pre-determined region and facilitates novel insights into the functional genomics of an organism. Emergence of genome editing has brought considerable excitement especially among agricultural scientists because of its simplicity, precision and power as it offers new opportunities to develop improved crop varieties with clear-cut addition of valuable traits or removal of undesirable traits. Research is underway to improve crop varieties with higher yields, strengthen stress tolerance, disease and pest resistance, decrease input costs, and increase nutritional value. Genome editing encompasses a wide variety of tools using either a site-specific recombinase (SSR) or a site-specific nuclease (SSN) system. Both systems require recognition of a known sequence. The SSN system generates single or double strand DNA breaks and activates endogenous DNA repair pathways. SSR technology, such as Cre/loxP and Flp/FRT mediated systems, are able to knockdown or knock-in genes in the genome of eukaryotes, depending on the orientation of the specific sites (loxP, FLP, etc.) flanking the target site. There are 4 main classes of SSN developed to cleave genomic sequences, mega-nucleases (homing endonuclease), zinc finger nucleases (ZFNs), transcriptional activator-like effector nucleases (TALENs), and the CRISPR/Cas nuclease system (clustered regularly interspaced short palindromic repeat/CRISPR-associated protein). The recombinase mediated genome engineering depends on recombinase (sub-) family and target-site and induces high frequencies of homologous recombination. Improving crops with gene editing provides a range of options: by altering only a few nucleotides from billions found in the genomes of living cells, altering the full allele or by inserting a new gene in a targeted region of

  5. Opportunities and challenges for time domain astronomy with LSST

    Science.gov (United States)

    Ivezic, Zeljko

    2014-01-01

    The Large Synoptic Survey Telescope (LSST) will enable faint optical time-domain astronomy by carrying out an imaging survey covering the sky that is visible from Cerro Pachon in Northern Chile. Of the order thousand 9.6 sq. deg. images (3.2 Gigapix) will be obtained per night using pairs of 15-second back-to-back exposures, with typical 5-sigma depth for point sources of 24.5 (AB). With close to 1000 observations of a 18,000 sq. deg. region in ugrizy bands over a 10-year period, these data will enable a deep stack across half the sky reaching five magnitudes deeper than the SDSS survey ( 27.5, 5 sigma, point source), and with twice as good seeing (0.7 arcsec median seeing in the r band). The measured and archived properties of newly discovered and known astrometric and photometric transients will be publicly reported within 60 sec after closing the shutter. Automated classification of the expected several million alerts per night, and selection of transient events requiring immediate follow-up, is an outstanding problem for the community. These data will represent a treasure trove for follow-up programs using other ground and space-based telescopes, such as fast-response fast-cadence photometric observations and spectroscopy, as well as for facilities operating at non-optical wavelengths and for gravitational wave programs. I will describe the relevant data products to be delivered by LSST and will summarize challenges that will need to be addressed by the community at large.

  6. Cements in the 21(st) Century: Challenges, Perspectives, and Opportunities.

    Science.gov (United States)

    Biernacki, Joseph J; Bullard, Jeffrey W; Sant, Gaurav; Banthia, Nemkumar; Brown, Kevin; Glasser, Fredrik P; Jones, Scott; Ley, Tyler; Livingston, Richard; Nicoleau, Luc; Olek, Jan; Sanchez, Florence; Shahsavari, Rouzbeh; Stutzman, Paul E; Sobolev, Konstantine; Prater, Tracie

    2017-07-01

    In a book published in 1906, Richard Meade outlined the history of portland cement up to that point(1). Since then there has been great progress in portland cement-based construction materials technologies brought about by advances in the materials science of composites and the development of chemical additives (admixtures) for applications. The resulting functionalities, together with its economy and the sheer abundance of its raw materials, have elevated ordinary portland cement (OPC) concrete to the status of most used synthetic material on Earth. While the 20(th) century was characterized by the emergence of computer technology, computational science and engineering, and instrumental analysis, the fundamental composition of portland cement has remained surprisingly constant. And, although our understanding of ordinary portland cement (OPC) chemistry has grown tremendously, the intermediate steps in hydration and the nature of calcium silicate hydrate (C-S-H), the major product of OPC hydration, remain clouded in uncertainty. Nonetheless, the century also witnessed great advances in the materials technology of cement despite the uncertain understanding of its most fundamental components. Unfortunately, OPC also has a tremendous consumption-based environmental impact, and concrete made from OPC has a poor strength-to-weight ratio. If these challenges are not addressed, the dominance of OPC could wane over the next 100 years. With this in mind, this paper envisions what the 21(st) century holds in store for OPC in terms of the driving forces that will shape our continued use of this material. Will a new material replace OPC, and concrete as we know it today, as the preeminent infrastructure construction material?

  7. Integrated Food-Energy Systems: Challenges and Opportunities

    Science.gov (United States)

    Gerst, M.; Cox, M. E.; Locke, K. A.; Laser, M.; Raker, M.; Gooch, C.; Kapuscinski, A. R.

    2015-12-01

    Predominant forms of food and energy systems pose multiple challenges to the environment as current configurations tend to be structured around centralized one-way through-put of materials and energy. One proposed form of system transformation involves locally integrating "unclosed" material and energy loops from food and energy systems. Such systems, which have been termed integrated food-energy systems (IFES), have existed in diverse niche forms but have not been systematically studied with respect to technological, governance, and environmental differences. This is likely because IFES can have widely different configurations, from co-located renewable energy production on cropland to agroforestry. As a first step in creating a synthesis of IFES, our research team constructed a taxonomy using exploratory data analysis of diverse IFES cases (Gerst et al., 2015, ES&T 49:734-741). It was found that IFES may be categorized by type of primary product produced (plant- or animal-based food or energy) and the degree and direction of vertical supply chain coordination. To further explore these implications, we have begun a study of a highly-coordinated, animal-driven IFES: dairy farms with biogas production from anaerobic digestion of manure. The objectives of the research are to understand the barriers to adoption and the potential benefits to the farms financial resilience and to the environment. To address these objectives, we are interviewing 50 farms across New York and Vermont, collecting information on farmer decision-making and farm operation. These results will be used to calibrate biophysical and economic models of the farm in order understand the future conditions under which adoption of an IFES is beneficial.

  8. Community Safety and Crime Prevention Partnerships: Challenges and Opportunities

    Directory of Open Access Journals (Sweden)

    Patrick Sheperdson

    2014-04-01

    Full Text Available In many jurisdictions around the world, community safety and crime prevention activity is supported by interagency committees. In the Australian state of New South Wales (NSW, local government Community Safety Officers (CSOs lead, support or participate in a range of interagency and ‘whole of government’ networks, most of which were established to support central NSW state government crime prevention and community safety initiatives. Research was conducted with the aim of exploring the CSOs’ experience of the ‘whole of government’ partnerships established to support community safety and crime prevention in NSW.[i] The findings support international research which suggests that central-local partnerships are inhibited by different agendas, responsibilities and power dynamics across different levels of government. Some of the key contextual challenges for this work include concerns about costs shifting from State to local government and about shifting State government priorities; barriers to funding and to accessing crime (and other data; and various administrative burdens. Consequently, we argued that there is a need for formal engagement and negotiation between, on the one hand, State government agencies that steer NSW crime prevention and, on the other, community safety policy initiatives and local government. Such engagement could help overcome the perception, indeed the reality, that shifting and dumping costs and responsibilities to local government is creating a range of burdens for CSOs. [i] The authors thank the NSW Local Government Community Safety and Crime Prevention Network and the individual local government CSOs who kindly assisted and contributed to this research.

  9. The Genetic Basis of Mendelian Phenotypes: Discoveries, Challenges, and Opportunities.

    Science.gov (United States)

    Chong, Jessica X; Buckingham, Kati J; Jhangiani, Shalini N; Boehm, Corinne; Sobreira, Nara; Smith, Joshua D; Harrell, Tanya M; McMillin, Margaret J; Wiszniewski, Wojciech; Gambin, Tomasz; Coban Akdemir, Zeynep H; Doheny, Kimberly; Scott, Alan F; Avramopoulos, Dimitri; Chakravarti, Aravinda; Hoover-Fong, Julie; Mathews, Debra; Witmer, P Dane; Ling, Hua; Hetrick, Kurt; Watkins, Lee; Patterson, Karynne E; Reinier, Frederic; Blue, Elizabeth; Muzny, Donna; Kircher, Martin; Bilguvar, Kaya; López-Giráldez, Francesc; Sutton, V Reid; Tabor, Holly K; Leal, Suzanne M; Gunel, Murat; Mane, Shrikant; Gibbs, Richard A; Boerwinkle, Eric; Hamosh, Ada; Shendure, Jay; Lupski, James R; Lifton, Richard P; Valle, David; Nickerson, Deborah A; Bamshad, Michael J

    2015-08-06

    Discovering the genetic basis of a Mendelian phenotype establishes a causal link between genotype and phenotype, making possible carrier and population screening and direct diagnosis. Such discoveries also contribute to our knowledge of gene function, gene regulation, development, and biological mechanisms that can be used for developing new therapeutics. As of February 2015, 2,937 genes underlying 4,163 Mendelian phenotypes have been discovered, but the genes underlying ∼50% (i.e., 3,152) of all known Mendelian phenotypes are still unknown, and many more Mendelian conditions have yet to be recognized. This is a formidable gap in biomedical knowledge. Accordingly, in December 2011, the NIH established the Centers for Mendelian Genomics (CMGs) to provide the collaborative framework and infrastructure necessary for undertaking large-scale whole-exome sequencing and discovery of the genetic variants responsible for Mendelian phenotypes. In partnership with 529 investigators from 261 institutions in 36 countries, the CMGs assessed 18,863 samples from 8,838 families representing 579 known and 470 novel Mendelian phenotypes as of January 2015. This collaborative effort has identified 956 genes, including 375 not previously associated with human health, that underlie a Mendelian phenotype. These results provide insight into study design and analytical strategies, identify novel mechanisms of disease, and reveal the extensive clinical variability of Mendelian phenotypes. Discovering the gene underlying every Mendelian phenotype will require tackling challenges such as worldwide ascertainment and phenotypic characterization of families affected by Mendelian conditions, improvement in sequencing and analytical techniques, and pervasive sharing of phenotypic and genomic data among researchers, clinicians, and families. Copyright © 2015 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  10. Russia And East Asia: New Opportunities And Challenges

    Directory of Open Access Journals (Sweden)

    Anna A. Kireeva

    2014-01-01

    Full Text Available The article focuses on major dimensions, achievements, challenges and prospects of relations between Russia and East Asia. Strategic importance of the region is shaped by East Asia's increasing role in world politics and economy as well as by its appeal for Russia's modernization agenda. Russia's great power status rests upon the effectiveness of its East Asian policy and development model of Siberia and the Russian Far East. Russia's positions in East Asia have improved substantially over the 2000s. However, its involvement in regional economic interaction is still insignificant and Russia cannot be regarded as a full-fledged regional player in this domain. Russian-Chinese strategic partnership has been the axis of Russia's East Asian foreign policy, though overdependence on China threatens Russia's independent policy in the region and encourages Russia to search for ways to diversify its ties. Russia's national interests reside in multivector policy, aimed at developing substantive relations not only with China but also with Japan, South Korea, ASEAN (Vietnam in the first place and India along with Russia's involvement in the resolution of Korean nuclear crisis. The rise of China and the US counter-offensive have resulted in a changing strategic environment in East Asia. A need for balancing between the US and China has brought about ASEAN countries' desire to welcome Russia as a "balancer" or an "honest player" in the region. It corresponds with Russia's course on playing a greater role in regional cooperation and integration. Russia's improving ties in political, economic, energy and security dimensions have the potential to contribute to the stability of the emerging polycentric regional order in East Asia and development of Russia's regions of Siberia and the Far East.

  11. RUSSIA AND EAST ASIA: NEW OPPORTUNITIES AND CHALLENGES

    Directory of Open Access Journals (Sweden)

    Anna A. Kireeva

    2014-01-01

    Full Text Available The article focuses on major dimensions, achievements, challenges and prospects of relations between Russia and East Asia. Strategic importance of the region is shaped by East Asia's increasing role in world politics and economy as well as by its appeal for Russia's modernization agenda. Russia's great power status rests upon the effectiveness of its East Asian policy and development model of Siberia and the Russian Far East. Russia's positions in East Asia have improved substantially over the 2000s. However, its involvement in regional economic interaction is still insignificant and Russia cannot be regarded as a full-fledged regional player in this domain. Russian-Chinese strategic partnership has been the axis of Russia's East Asian foreign policy, though overdependence on China threatens Russia's independent policy in the region and encourages Russia to search for ways to diversify its ties. Russia's national interests reside in multivector policy, aimed at developing substantive relations not only with China but also with Japan, South Korea, ASEAN (Vietnam in the first place and India along with Russia's involvement in the resolution of Korean nuclear crisis. The rise of China and the US counter-offensive have resulted in a changing strategic environment in East Asia. A need for balancing between the US and China has brought about ASEAN countries' desire to welcome Russia as a "balancer" or an "honest player" in the region. It corresponds with Russia's course on playing a greater role in regional cooperation and integration. Russia's improving ties in political, economic, energy and security dimensions have the potential to contribute to the stability of the emerging polycentric regional order in East Asia and development of Russia's regions of Siberia and the Far East.

  12. Immuno-oncology Clinical Trial Design: Limitations, Challenges, and Opportunities.

    Science.gov (United States)

    Baik, Christina S; Rubin, Eric H; Forde, Patrick M; Mehnert, Janice M; Collyar, Deborah; Butler, Marcus O; Dixon, Erica L; Chow, Laura Q M

    2017-09-01

    Recent advances in immuno-oncology and regulatory approvals have been rapid and paradigm shifting in many difficult-to-treat malignancies. Despite immune checkpoint inhibitor therapy becoming the standard of care across multiple tumor types, there are many unanswered questions that need to be addressed before this therapeutic modality can be fully harnessed. Areas of limitations include treatment of patients not sufficiently represented in clinical trials, uncertainty of the optimal treatment dosing and duration, and lack of understanding regarding long-term immune related toxicities and atypical tumor responses. Patients such as those with autoimmune disease, chronic viral infections, limited performance status, and brain metastases were often excluded from initial trials due to concerns of safety. However, limited data suggest that some of these patients can benefit from therapy with manageable toxicities; thus, future studies should incorporate these patients to clearly define safety and efficacy. There are still controversies regarding the optimal dosing strategy that can vary from weight-based to flat dosing, with undefined treatment duration. Further elucidation of the optimal dosing approach and evaluation of predictive biomarkers should be incorporated in the design of future trials. Finally, there are long-term immune-mediated toxicities, atypical tumor responses such as pseudoprogression and endpoints unique to immuno-oncology that are not adequately captured by traditional trial designs; thus, novel study designs are needed. In this article, we discuss in detail the above challenges and propose needed areas of research for exploration and incorporation in the next generation of immuno-oncology clinical trials. ©2017 American Association for Cancer Research.

  13. Challenges and opportunities in land surface modelling of savanna ecosystems

    Directory of Open Access Journals (Sweden)

    R. Whitley

    2017-10-01

    Full Text Available The savanna complex is a highly diverse global biome that occurs within the seasonally dry tropical to sub-tropical equatorial latitudes and are structurally and functionally distinct from grasslands and forests. Savannas are open-canopy environments that encompass a broad demographic continuum, often characterised by a changing dominance between C3-tree and C4-grass vegetation, where frequent environmental disturbances such as fire modulates the balance between ephemeral and perennial life forms. Climate change is projected to result in significant changes to the savanna floristic structure, with increases to woody biomass expected through CO2 fertilisation in mesic savannas and increased tree mortality expected through increased rainfall interannual variability in xeric savannas. The complex interaction between vegetation and climate that occurs in savannas has traditionally challenged terrestrial biosphere models (TBMs, which aim to simulate the interaction between the atmosphere and the land surface to predict responses of vegetation to changing in environmental forcing. In this review, we examine whether TBMs are able to adequately represent savanna fluxes and what implications potential deficiencies may have for climate change projection scenarios that rely on these models. We start by highlighting the defining characteristic traits and behaviours of savannas, how these differ across continents and how this information is (or is not represented in the structural framework of many TBMs. We highlight three dynamic processes that we believe directly affect the water use and productivity of the savanna system: phenology, root-water access and fire dynamics. Following this, we discuss how these processes are represented in many current-generation TBMs and whether they are suitable for simulating savanna fluxes.Finally, we give an overview of how eddy-covariance observations in combination with other data sources can be used in model

  14. Challenges and opportunities in land surface modelling of savanna ecosystems

    Science.gov (United States)

    Whitley, Rhys; Beringer, Jason; Hutley, Lindsay B.; Abramowitz, Gabriel; De Kauwe, Martin G.; Evans, Bradley; Haverd, Vanessa; Li, Longhui; Moore, Caitlin; Ryu, Youngryel; Scheiter, Simon; Schymanski, Stanislaus J.; Smith, Benjamin; Wang, Ying-Ping; Williams, Mathew; Yu, Qiang

    2017-10-01

    The savanna complex is a highly diverse global biome that occurs within the seasonally dry tropical to sub-tropical equatorial latitudes and are structurally and functionally distinct from grasslands and forests. Savannas are open-canopy environments that encompass a broad demographic continuum, often characterised by a changing dominance between C3-tree and C4-grass vegetation, where frequent environmental disturbances such as fire modulates the balance between ephemeral and perennial life forms. Climate change is projected to result in significant changes to the savanna floristic structure, with increases to woody biomass expected through CO2 fertilisation in mesic savannas and increased tree mortality expected through increased rainfall interannual variability in xeric savannas. The complex interaction between vegetation and climate that occurs in savannas has traditionally challenged terrestrial biosphere models (TBMs), which aim to simulate the interaction between the atmosphere and the land surface to predict responses of vegetation to changing in environmental forcing. In this review, we examine whether TBMs are able to adequately represent savanna fluxes and what implications potential deficiencies may have for climate change projection scenarios that rely on these models. We start by highlighting the defining characteristic traits and behaviours of savannas, how these differ across continents and how this information is (or is not) represented in the structural framework of many TBMs. We highlight three dynamic processes that we believe directly affect the water use and productivity of the savanna system: phenology, root-water access and fire dynamics. Following this, we discuss how these processes are represented in many current-generation TBMs and whether they are suitable for simulating savanna fluxes.Finally, we give an overview of how eddy-covariance observations in combination with other data sources can be used in model benchmarking and

  15. The GLOBE Program 10 Years On: Challenges and Opportunities

    Science.gov (United States)

    Blurton, C.

    2004-12-01

    ). This session will examine what was accomplished during GLOBE's first 10 years as a Federal program, what challenges the Program faces, and what plans are afoot for GLOBE's next ten years under UCAR's leadership.

  16. Engaging with Families Is a Challenge: Beliefs among Healthcare Professionals in Forensic Psychiatric Care

    Science.gov (United States)

    Hörberg, Ulrica; Erlingsson, Christen; Syrén, Susanne

    2015-01-01

    Being healthcare professionals in the complex field of forensic psychiatry care (FPC) seems particularly challenging. Historically, families have almost been invisible in FPC. The aim of this study was to uncover beliefs among healthcare professionals concerning families of patients admitted for FPC. Using a hermeneutical approach inspired by Gadamer's philosophy, group interviews with healthcare professionals in four Swedish forensic psychiatric clinics were analyzed. Analysis resulted in seven key beliefs. There were three beliefs about families: family belongingness is a resource for the patient; most families are broken and not possible to trust; and most families get in the way of the patient's care. Four beliefs concerned encounters with families: it is important to achieve a balance and control over the family; it is essential to set aside one's own values and morals; family-oriented work is an impossible mission; and family oriented work requires welcoming the families. Despite ethical dilemmas of working with families in FPC, healthcare professionals showed a willingness and desire to work in a more family-oriented manner. More knowledge, understanding, and caring tools are needed in order to meet the needs of the family as well as support the family's resources. PMID:26448874

  17. Challenges and Opportunities in Modeling of the Global Atmosphere

    Science.gov (United States)

    Janjic, Zavisa; Djurdjevic, Vladimir; Vasic, Ratko

    2016-04-01

    are comparable to the scales of the dominant Rossby waves, such fictitious solutions are hard to identify and remove. Another new challenge on the global scale is that the limit of validity of the hydrostatic approximation is rapidly being approached. Relaxing the hydrostatic approximation requieres careful reformulation of the model dynamics and more computations and communications. The unified Non-hydrostatic Multi-scale Model (NMMB) will be briefly discussed as an example. The non-hydrostatic dynamics were designed in such a way as to avoid over-specification. The global version is run on the latitude-longitude grid, and the polar filter selectively slows down the waves that would otherwise be unstable without modifying their amplitudes. The model has been successfully tested on various scales. The skill of the medium range forecasts produced by the NMMB is comparable to that of other major medium range models, and its computational efficiency on parallel computers is good.

  18. Healthcare workers' challenges in the implementation of tuberculosis infection prevention and control measures in Mozambique.

    Directory of Open Access Journals (Sweden)

    Miranda Brouwer

    Full Text Available Healthcare Workers (HCWs have a higher frequency of TB exposure than the general population and have therefore an occupational TB risk that infection prevention and control (IPC measures aim to reduce. HCWs are crucial in the implementation of these measures. The objective of the study was to investigate Mozambican HCWs' perceptions of their occupational TB risk and the measures they report using to reduce this risk. In addition, we explored the challenges HCWs encounter while using these TBIPC measures.Focus group discussion. Analysis according content method.Four categories of HCWs: auxiliary workers, medical (doctors and clinical officers, nurses and TB program staff.HCWs are aware of their occupational TB risk and use various measures to reduce their risk of infection. HCWs find it challenging to employ measures that minimize such risks and a lack of clear guidelines contributes to these challenges. HCWs' and patient behavior further complicate the use of TBIPC measures.HCWs in Mozambique perceive a high occupational risk of TB infection. They report several challenges using measures to reduce this risk such as shortage of material, lack of clear guidelines, insufficient motivation and inadequate training. Robust training with motivational approaches, alongside supervision and support for HCWs could improve implementation of TBIPC measures. Healthcare management should address the areas for improvement that are beyond the individual HCW's control.

  19. Healthcare workers' challenges in the implementation of tuberculosis infection prevention and control measures in Mozambique.

    Science.gov (United States)

    Brouwer, Miranda; Coelho, Eliana; Mosse, Carla das Dores; Brondi, Luciana; Winterton, Laura; van Leth, Frank

    2014-01-01

    Healthcare Workers (HCWs) have a higher frequency of TB exposure than the general population and have therefore an occupational TB risk that infection prevention and control (IPC) measures aim to reduce. HCWs are crucial in the implementation of these measures. The objective of the study was to investigate Mozambican HCWs' perceptions of their occupational TB risk and the measures they report using to reduce this risk. In addition, we explored the challenges HCWs encounter while using these TBIPC measures. Focus group discussion. Analysis according content method. Four categories of HCWs: auxiliary workers, medical (doctors and clinical officers), nurses and TB program staff. HCWs are aware of their occupational TB risk and use various measures to reduce their risk of infection. HCWs find it challenging to employ measures that minimize such risks and a lack of clear guidelines contributes to these challenges. HCWs' and patient behavior further complicate the use of TBIPC measures. HCWs in Mozambique perceive a high occupational risk of TB infection. They report several challenges using measures to reduce this risk such as shortage of material, lack of clear guidelines, insufficient motivation and inadequate training. Robust training with motivational approaches, alongside supervision and support for HCWs could improve implementation of TBIPC measures. Healthcare management should address the areas for improvement that are beyond the individual HCW's control.

  20. Implementing non-invasive prenatal testing for aneuploidy in a national healthcare system: global challenges and national solutions

    NARCIS (Netherlands)

    van Schendel, Rachèl V.; van El, Carla G.; Pajkrt, Eva; Henneman, Lidewij; Cornel, Martina C.

    2017-01-01

    Background: Since the introduction of non-invasive prenatal testing (NIPT) in 2011, mainly by commercial companies, a growing demand for NIPT from the public and healthcare professionals has been putting pressure on the healthcare systems of various countries. This study identifies the challenges of

  1. Using Electronic Health Records for Quality Measurement and Accountability in Care of the Seriously Ill: Opportunities and Challenges.

    Science.gov (United States)

    Curtis, J Randall; Sathitratanacheewin, Seelwan; Starks, Helene; Lee, Robert Y; Kross, Erin K; Downey, Lois; Sibley, James; Lober, William; Loggers, Elizabeth T; Fausto, James A; Lindvall, Charlotta; Engelberg, Ruth A

    2018-03-01

    As our population ages and the burden of chronic illness rises, there is increasing need to implement quality metrics that measure and benchmark care of the seriously ill, including the delivery of both primary care and specialty palliative care. Such metrics can be used to drive quality improvement, value-based payment, and accountability for population-based outcomes. In this article, we examine use of the electronic health record (EHR) as a tool to assess quality of serious illness care through narrative review and description of a palliative care quality metrics program in a large healthcare system. In the search for feasible, reliable, and valid palliative care quality metrics, the EHR is an attractive option for collecting quality data on large numbers of seriously ill patients. However, important challenges to using EHR data for quality improvement and accountability exist, including understanding the validity, reliability, and completeness of the data, as well as acknowledging the difference between care documented and care delivered. Challenges also include developing achievable metrics that are clearly linked to patient and family outcomes and addressing data interoperability across sites as well as EHR platforms and vendors. This article summarizes the strengths and weakness of the EHR as a data source for accountability of community- and population-based programs for serious illness, describes the implementation of EHR data in the palliative care quality metrics program at the University of Washington, and, based on that experience, discusses opportunities and challenges. Our palliative care metrics program was designed to serve as a resource for other healthcare systems. Although the EHR offers great promise for enhancing quality of care provided for the seriously ill, significant challenges remain to operationalizing this promise on a national scale and using EHR data for population-based quality and accountability.

  2. Using the Electronic Health Record in Nursing Research: Challenges and Opportunities.

    Science.gov (United States)

    Samuels, Joanne G; McGrath, Robert J; Fetzer, Susan J; Mittal, Prashant; Bourgoine, Derek

    2015-10-01

    Changes in the patient record from the paper to the electronic health record format present challenges and opportunities for the nurse researcher. Current use of data from the electronic health record is in a state of flux. Novel data analytic techniques and massive data sets provide new opportunities for nursing science. Realization of a strong electronic data output future relies on meeting challenges of system use and operability, data presentation, and privacy. Nurse researchers need to rethink aspects of proposal development. Joining ongoing national efforts aimed at creating usable data output is encouraged as a means to affect system design. Working to address challenges and embrace opportunities will help grow the science in a way that answers important patient care questions. © The Author(s) 2015.

  3. A Systematic Review of Wearable Patient Monitoring Systems - Current Challenges and Opportunities for Clinical Adoption.

    Science.gov (United States)

    Baig, Mirza Mansoor; GholamHosseini, Hamid; Moqeem, Aasia A; Mirza, Farhaan; Lindén, Maria

    2017-07-01

    The aim of this review is to investigate barriers and challenges of wearable patient monitoring (WPM) solutions adopted by clinicians in acute, as well as in community, care settings. Currently, healthcare providers are coping with ever-growing healthcare challenges including an ageing population, chronic diseases, the cost of hospitalization, and the risk of medical errors. WPM systems are a potential solution for addressing some of these challenges by enabling advanced sensors, wearable technology, and secure and effective communication platforms between the clinicians and patients. A total of 791 articles were screened and 20 were selected for this review. The most common publication venue was conference proceedings (13, 54%). This review only considered recent studies published between 2015 and 2017. The identified studies involved chronic conditions (6, 30%), rehabilitation (7, 35%), cardiovascular diseases (4, 20%), falls (2, 10%) and mental health (1, 5%). Most studies focussed on the system aspects of WPM solutions including advanced sensors, wireless data collection, communication platform and clinical usability based on a specific area or disease. The current studies are progressing with localized sensor-software integration to solve a specific use-case/health area using non-scalable and 'silo' solutions. There is further work required regarding interoperability and clinical acceptance challenges. The advancement of wearable technology and possibilities of using machine learning and artificial intelligence in healthcare is a concept that has been investigated by many studies. We believe future patient monitoring and medical treatments will build upon efficient and affordable solutions of wearable technology.

  4. Development of healthcare waste management in Serbia and challenges in the improvement of the quality of healthcare services

    Directory of Open Access Journals (Sweden)

    Jovanović Verica S.

    2014-01-01

    Full Text Available Proper Healthcare Waste Management (HCWM was introduced in the Republic of Serbia in 2007 with the support of the European Union. Since then, the amounts of waste treated, prior to landfill, have steadily increased and more and more healthcare institutions adopted HCWM systems. In parallel large numbers of healthcare workers were trained in proper HCWM. This study quantifies the progress made. The study analyzed the period 2009 to 2012 using three methods of data collection. On basis of data collected, it has been established that with a population of just over seven million, Serbia generates between 4,500 and 5,000 tones of infectious waste on an annual basis of which some 20% originates from the treatment of out-patients, 75% from the treatment of in-patients and 5% from micro-biological laboratory tests. While in 2009 only one third of this waste was treated prior to disposal, this fraction has increased to two thirds in 2011. The data also show that more than 90% of healthcare facilities have developed individual healthcare waste management plans up from less than 20% in 2009. In every healthcare facility there are at least 2 people trained in healthcare waste management, and in total there are approximately 3000 staff members who received formal HCWM training provided through the Institute for Public Health. Healthcare waste management is continuously improving in the Republic of Serbia and is well established in more than 85% of healthcare facilities. There are still issues to be improved especially regarding treatment on healthcare waste other than infectious waste.

  5. The impact of social media on medical professionalism: a systematic qualitative review of challenges and opportunities.

    Science.gov (United States)

    Gholami-Kordkheili, Fatemeh; Wild, Verina; Strech, Daniel

    2013-08-28

    The rising impact of social media on the private and working lives of health care professionals has made researchers and health care institutions study and rethink the concept and content of medical professionalism in the digital age. In the last decade, several specific policies, original research studies, and comments have been published on the responsible use of social media by health care professionals. However, there is no systematic literature review that analyzes the full spectrum of (1) social media-related challenges imposed on medical professionalism and (2) social media-related opportunities to both undermine and improve medical professionalism. The aim of this systematic qualitative review is to present this full spectrum of social media-related challenges and opportunities. We performed a systematic literature search in PubMed (restricted to English and German literature published between 2002 and 2011) for papers that address social media-related challenges and opportunities for medical professionalism. To operationalize "medical professionalism", we refer to the 10 commitments presented in the physicians' charter "Medical professionalism in the new millennium" published by the ABIM Foundation. We applied qualitative text analysis to categorize the spectrum of social media-related challenges and opportunities for medical professionalism. The literature review retrieved 108 references, consisting of 46 original research studies and 62 commentaries, editorials, or opinion papers. All references together mentioned a spectrum of 23 broad and 12 further-specified, narrow categories for social media-related opportunities (n=10) and challenges (n=13) for medical professionalism, grouped under the 10 commitments of the physicians' charter. The accommodation of the traditional core values of medicine to the characteristics of social media presents opportunities as well as challenges for medical professionalism. As a profession that is entitled to self

  6. Take the Money and Run: The Challenges of Designing and Evaluating Financial Incentives in Healthcare; Comment on “Paying for Performance in Healthcare Organisations”

    Directory of Open Access Journals (Sweden)

    Russell Mannion

    2014-02-01

    Full Text Available Many countries are turning their attention to the use of explicit financial incentives to drive desired improvements in healthcare performance. However, we have only a weak evidence-base to inform policy in this area. The research challenge is to generate robust evidence on what financial incentives work, under what circumstances, for whom and with what intended and unintended consequences.

  7. Take the money and run: the challenges of designing and evaluating financial incentives in healthcare; Comment on "Paying for performance in healthcare organisations".

    Science.gov (United States)

    Mannion, Russell

    2014-02-01

    Many countries are turning their attention to the use of explicit financial incentives to drive desired improvements in healthcare performance. However, we have only a weak evidence-base to inform policy in this area. The research challenge is to generate robust evidence on what financial incentives work, under what circumstances, for whom and with what intended and unintended consequences.

  8. Take the Money and Run: The Challenges of Designing and Evaluating Financial Incentives in Healthcare; Comment on “Paying for Performance in Healthcare Organisations”

    OpenAIRE

    Russell Mannion

    2014-01-01

    Many countries are turning their attention to the use of explicit financial incentives to drive desired improvements in healthcare performance. However, we have only a weak evidence-base to inform policy in this area. The research challenge is to generate robust evidence on what financial incentives work, under what circumstances, for whom and with what intended and unintended consequences.

  9. Motivation, Challenge, and Opportunity of Successful Solvers on an Innovation Platform

    DEFF Research Database (Denmark)

    Hossain, Mokter

    2017-01-01

    The objective of this study is to identify motivations, challenges, and opportunities of successful solvers participating in virtual teams of innovation contests (ICs) organized by an innovation intermediary. Based on 82 interviews of successful solvers, this study provides novel insights into ICs....... The main motivational factors of successful solvers engaged in problem solving are money, learning, fun, sense of achievement, passion, and networking. Major challenges solvers face include unclear or insufficient problem description, lack of option for communication, language barrier, time zone...

  10. Motivation, Challenge, and Opportunity of Successful Solvers on an Innovation Platform

    DEFF Research Database (Denmark)

    Hossain, Mokter

    2017-01-01

    . The main motivational factors of successful solvers engaged in problem solving are money, learning, fun, sense of achievement, passion, and networking. Major challenges solvers face include unclear or insufficient problem description, lack of option for communication, language barrier, time zone...... differences, difficulties in finding suitable team members, framing the results, and difficulties in becoming quick learners and team players. Despite challenges, solvers have many opportunities, such as diversified knowledge, learning culture, developing a different way of thinking, gaining insights from...

  11. Integrating mercury science and policy in the marine context: Challenges and opportunities

    OpenAIRE

    Lambert, Kathleen F.; Evers, David C.; Warner, Kimberly A.; King, Susannah L.; Selin, Noelle E

    2012-01-01

    Mercury is a global pollutant and presents policy challenges at local, regional, and global scales. Mercury poses risks to the health of people, fish, and wildlife exposed to elevated levels of mercury, most commonly from the consumption of methylmercury in marine and estuarine fish. The patchwork of current mercury abatement efforts limits the effectiveness of national and multi-national policies. This paper provides an overview of the major policy challenges and opportunities related to mer...

  12. An exploration of opportunities and challenges facing cervical cancer managers in Kenya

    OpenAIRE

    Kivuti-Bitok, Lucy W; Pokhariyal, Ganesh P; Abdul, Roudsari; McDonnell, Geoff

    2013-01-01

    Background Kenya like other developing countries is low in resource setting and is facing a number of challenges in the management of cervical cancer. This study documents opportunities and challenges encountered in managing cervical cancer from the health care workers? perspectives. A qualitative study was conducted among cervical cancer managers who were defined as nurses and doctors involved in operational level management of cervical cancer. The respondents were drawn from four provincial...

  13. Hydrogen storage for fuel cell applications: Challenges, opportunities and prospects for metal-organic frameworks

    CSIR Research Space (South Africa)

    Langmi, Henrietta W

    2013-07-01

    Full Text Available CELL APPLICATIONS: CHALLENGES, OPPORTUNITIES AND PROSPECTS FOR METAL-ORGANIC FRAMEWORKS Korea-South Africa H2 Fuel Cell Collaboration Workshop,15-18 July 2013, Hyundai Hotel, Gyeongju, Rep. of Korea Dr. Henrietta Langmi, Hy...% Russia 12% North America 5% Others 4% PGM Supply by region Slide 6 Strategic Goals  Establish a base for hydrogen production, storage technologies...

  14. Bringing Together Interactive Digital Storytelling with Tangible Interaction : Challenges and Opportunities

    NARCIS (Netherlands)

    Catala, Alejandro; Theune, Mariët; Sylla, Cristina; Ribeiro, Pedro; Nunes, Nuno; Oakley, Ian; Nisi, Valentina

    2017-01-01

    This workshop aims to explore challenges and potential opportunities in bringing interactive digital storytelling into the realm of tangible and embodied interaction. To this end, experts from both fields are invited to present and discuss their ideas. Besides fostering discussion and potential

  15. The Practice of School Psychology in Quebec English Schools: Current Challenges and Opportunities

    Science.gov (United States)

    Finn, Cindy A.

    2016-01-01

    In Quebec, school psychology is alive and well. This article outlines current challenges and opportunities related to the practice of psychology in Quebec English schools. Changes to the practice of psychology in Quebec over the last decade have had an impact on the delivery of psychological services in schools. Modifications of the admission…

  16. Rethinking Education of Deaf Children in Zimbabwe: Challenges and Opportunities for Teacher Education

    Science.gov (United States)

    Musengi, Martin; Ndofirepi, Amasa; Shumba, Almon

    2013-01-01

    The study explores the communication challenges faced by teacher trainees in teaching deaf learners and the opportunities that they present. A critical disabilities study approach within the qualitative paradigm was employed to collect interview data from 14 trainee teachers (6 were men and 8 women) and 5 of their specialist mentors (all of them…

  17. Public Health Nursing in the 21st Century: Challenges and Opportunities for Women and Children's Health

    OpenAIRE

    Peckover, Sue; Mogotlane, Sophie; Glavin, Kari; Aston, Megan

    2013-01-01

    This special issue focuses upon public health nursing with women and children in the 21st century. There are 6 papers which address a range of topics illustrating some of the opportunities and challenges arising in this area of nursing work from Ireland, Norway, Finland, UK, Canada, and Brazil.

  18. Historical Analysis of the Challenges and Opportunities of Higher Education in Ethiopia

    Science.gov (United States)

    Bishaw, Alemayehu; Melesse, Solomon

    2017-01-01

    There is a massive higher education expansion in Ethiopia. However, the efforts to expand higher education are characterized by great opportunities and significant challenges. The current higher education policy formulation and practice are the result of long history of traditional education in Ethiopia, the western countries' influence and the…

  19. Challenges & opportunities for Open Online Education – A group concept mapping study

    NARCIS (Netherlands)

    Schophuizen, Martine; Kreijns, Karel; Stoyanov, Slavi; Kalz, Marco

    2017-01-01

    The study presented in this poster identified expert consensus for challenges and opportunities for OOE. Some outcomes considered most important, were among those considered most difficult to influence by an institution. However,there are also outcomes that are important, and within the circle of

  20. Descriptive study of an emergency centre in Western Kenya: Challenges and opportunities

    Directory of Open Access Journals (Sweden)

    Darlene R. House

    2014-03-01

    Conclusions: The most common presentation for acute care in western Kenya was injury related. However, the severity of illness, lack of pre-hospital transportation, and lack of community mental health services provide significant challenges and opportunities for developing ECs in sub-Saharan Africa.