WorldWideScience

Sample records for health damage caused

  1. Valuing the human health damage caused by the fraud of Volkswagen

    International Nuclear Information System (INIS)

    Oldenkamp, Rik; Zelm, Rosalie van; Huijbregts, Mark A.J.

    2016-01-01

    Recently it became known that Volkswagen Group has been cheating with emission tests for diesel engines over the last six years, resulting in on-road emissions vastly exceeding legal standards for nitrogen oxides in Europe and the United States. Here, we provide an estimate of the public health consequences caused by this fraud. From 2009 to 2015, approximately nine million fraudulent Volkswagen cars, as sold in Europe and the US, emitted a cumulative amount of 526 ktonnes of nitrogen oxides more than was legally allowed. These fraudulent emissions are associated with 45 thousand disability-adjusted life years (DALYs) and a value of life lost of at least 39 billion US dollars, which is approximately 5.3 times larger than the 7.3 billion US dollars that Volkswagen Group has set aside to cover worldwide costs related to the diesel emissions scandal. - Highlights: • Health damages from Volkswagen's emission fraud are estimated in the USA and Europe. • Combined health damages in the USA and Europe are estimated at 45 thousand DALYs. • Health damages will further increase to 119 thousand DALYs if cars are not recalled. • Combined health costs in the USA and Europe are estimated at 39 billion US dollars. • Costs will further increase to 102 billion US dollars if cars are not recalled. - The diesel emission fraud committed by Volkswagen Group has led to substantial unforeseen emissions of nitrogen oxides and subsequent health damage costs in Europe and the US.

  2. [Prevention and control of air pollution needs to strengthen further study on health damage caused by air pollution].

    Science.gov (United States)

    Wu, T C

    2016-08-06

    Heath issues caused by air pollution such as particulate matter (PM) are much concerned and focused among air, water and soil pollutions because human breathe air for whole life span. Present comments will review physical and chemical characteristics of PM2.5 and PM10; Dose-response associations of PM10, PM2.5 and their components with mortality and risk of cardiopulmonary diseases, early health damages such as the decrease of lung functions and heart rate variability, DNA damage; And the roles of genetic variations and epigenetic changes in lung functions and heart rate variability, DNA damage related to PMs and their components. This comments list some limitations and perspectives about the associations of air pollution with health.

  3. Valuing the human health damage caused by the fraud of Volkswagen.

    Science.gov (United States)

    Oldenkamp, Rik; van Zelm, Rosalie; Huijbregts, Mark A J

    2016-05-01

    Recently it became known that Volkswagen Group has been cheating with emission tests for diesel engines over the last six years, resulting in on-road emissions vastly exceeding legal standards for nitrogen oxides in Europe and the United States. Here, we provide an estimate of the public health consequences caused by this fraud. From 2009 to 2015, approximately nine million fraudulent Volkswagen cars, as sold in Europe and the US, emitted a cumulative amount of 526 ktonnes of nitrogen oxides more than was legally allowed. These fraudulent emissions are associated with 45 thousand disability-adjusted life years (DALYs) and a value of life lost of at least 39 billion US dollars, which is approximately 5.3 times larger than the 7.3 billion US dollars that Volkswagen Group has set aside to cover worldwide costs related to the diesel emissions scandal. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. The assessment of health damage caused by air pollution and its implication for policy making in Taiyuan, Shanxi, China

    International Nuclear Information System (INIS)

    Zhang Daisheng; Aunan, Kristin; Seip, Hans Martin; Larssen, Steinar; Liu Jianhui; Zhang Dingsheng

    2010-01-01

    We establish the link between energy use, air pollution, and public health impacts in Taiyuan for 2000, and for 2010 and 2015 under alternative scenarios. We find that in year 2000 more than 2200 excess deaths may have been caused by particulate matter (PM) pollution. Using alternative methods for monetization of health impacts the total health damage amounts to 0.8-1.7 billion Yuan, which is 2.4-4.9% of the city's GDP in 2000. Compared to the business-as-usual scenario, scenarios assuming extensive fuel switch in low-and-medium-stack pollution sources and extension of the district heating system could prevent 200-1100 PM 10 -related premature deaths in 2010 and substantially reduce population morbidity. The actual PM pollution in 2007 was lower than modeled in these two scenarios. We also find that if air quality in urban Taiyuan were to reach the Chinese National Grade II Standard in 2015, the number of premature deaths would still be around 1330 and the economic cost about 1-2% of the city's GDP in 2015. Our results imply that there are large health benefits to be gained by setting stricter standards for the future in China, and that targeting low-and-medium-stack source effectively reduces health damage.

  5. Valuing the human health damage caused by the fraud of Volkswagen

    NARCIS (Netherlands)

    Oldenkamp, R.; Zelm, R. van; Huijbregts, M.A.J.

    2016-01-01

    Recently it became known that Volkswagen Group has been cheating with emission tests for diesel engines over the last six years, resulting in on-road emissions vastly exceeding legal standards for nitrogen oxides in Europe and the United States. Here, we provide an estimate of the public health

  6. Irreversible brain damage caused by methamphetamine

    Directory of Open Access Journals (Sweden)

    Sebastian Moeller

    2016-03-01

    Full Text Available Methamphetamine is an addictive scene substance usage of which is increasing rapidly. While methamphetamine often causes neuropsychiatric symptoms like anxiety, psychosis and hallucinations, reports of structural ongoing cerebral alterations are rare. We here report a case of this kind of damage caused through methamphetamine use.

  7. Cause of Damage. Hot cracking; Schadensursache Heissrissigkeit

    Energy Technology Data Exchange (ETDEWEB)

    Wader, Therese [BENTELER Steel/Tube GmbH, Paderborn (Germany). Vorentwicklung Werkstoffe

    2016-10-15

    Under certain conditions, Nb-containing stainless steels are susceptible to hot cracking. Such conditions include low melting phases on the grain boundaries, a coarse-grained microstructure such as cast structures, microstructure orientations towards the main tensile direction and high processing temperatures. The case of damage was characterized using metallographic and microanalytical methods. In the laboratory, the critical temperature range for the formation of hot cracks could furthermore specifically be localized under mechanical stresses by means of a dilatometer aiming at clearly verifying the cause of the damage, namely ''hot cracks''.

  8. Is eye damage caused by stereoscopic displays?

    Science.gov (United States)

    Mayer, Udo; Neumann, Markus D.; Kubbat, Wolfgang; Landau, Kurt

    2000-05-01

    A normal developing child will achieve emmetropia in youth and maintain it. Thereby cornea, lens and axial length of the eye grow astonishingly coordinated. In the last years research has evidenced that this coordinated growing process is a visually controlled closed loop. The mechanism has been studied particularly in animals. It was found that the growth of the axial length of the eyeball is controlled by image focus information from the retina. It was shown that maladjustment can occur by this visually-guided growth control mechanism that result in ametropia. Thereby it has been proven that e.g. short-sightedness is not only caused by heredity, but is acquired under certain visual conditions. It is shown that these conditions are similar to the conditions of viewing stereoscopic displays where the normal accommodation convergence coupling is disjoint. An evaluation is given of the potential of damaging the eyes by viewing stereoscopic displays. Concerning this, different viewing methods for stereoscopic displays are evaluated. Moreover, clues are given how the environment and display conditions shall be set and what users shall be chosen to minimize the risk of eye damages.

  9. Landslide Caused Damages in a Gallery

    Science.gov (United States)

    Poisel, R.; Mair am Tinkhof, K.; Preh, A.

    2016-06-01

    On October 5th, 2010, cracks were found in a gallery 1.8 m high and 1.4 m wide. The gallery is 100 years old, runs parallel to a valley flank and was excavated in a tectonically strongly stressed, weathered and slightly dipping sandwich of clayey shales, sandstones and marls. The cracks in the roof as well as in the invert ran parallel to the axis of the gallery. Monitoring showed that crack widths were increasing 1.5 mm per year, sidewall distances were increasing 3.5 mm per year, whereas the height of the gallery was decreasing 2.5 mm per year. After eliminating several possible causes of cracking, a landslide producing the damages had to be taken into consideration. Monitoring of the valley flank surface as well as inclinometer readings revealed that a landslide was occurring, loading the gallery lining. Most probably the landslide had been reactivated by excessive rainfall in 2009 as well as by works for the renewal of a weir in the valley bottom. As stabilization of the slope was not an option for several reasons, it was decided to replace the gallery by a new one deeper inside the slope, which will be ready for operation in 2017. Thus the old gallery has to be kept in operation till then and it was decided to reinforce the old gallery by a heavily reinforced shotcrete lining 10 cm thick. As slope displacements went on, cracks in the shotcrete lining developed with a completely different pattern: in the section where the gallery lies completely in the landslide shear zone no cracks formed until now due to heavy reinforcement, whereas in the transition sections stable ground-landslide and landslide-stable ground diagonal tension cracks in the roof due to shear by the landslide developed. Numerical models showed that cracking and spalling of the shotcrete lining would occur only after some centimetres of additional displacements of the slope, which hopefully will not occur before 2017.

  10. Genetic doping and health damages.

    Science.gov (United States)

    Fallahi, Aa; Ravasi, Aa; Farhud, Dd

    2011-01-01

    Use of genetic doping or gene transfer technology will be the newest and the lethal method of doping in future and have some unpleasant consequences for sports, athletes, and outcomes of competitions. The World Anti-Doping Agency (WADA) defines genetic doping as "the non-therapeutic use of genes, genetic elements, and/or cells that have the capacity to enhance athletic performance ". The purpose of this review is to consider genetic doping, health damages and risks of new genes if delivered in athletes. This review, which is carried out by reviewing relevant publications, is primarily based on the journals available in GOOGLE, ELSEVIER, PUBMED in fields of genetic technology, and health using a combination of keywords (e.g., genetic doping, genes, exercise, performance, athletes) until July 2010. There are several genes related to sport performance and if they are used, they will have health risks and sever damages such as cancer, autoimmunization, and heart attack.

  11. Wooden beverage cases cause little damage to bottle caps

    Science.gov (United States)

    R. Bruce Anderson; William C. Miller

    1973-01-01

    Wooden beverage cases cause little damage to aluminum resealable caps during distribution. A study at bottling plants and distribution warehouses showed that an average of 1 bottle out of 4,000 has cap damage. Most of the damage was attributed to handling at the warehouse and in transit. Some recommendations are given for improvement of wooden beverage cases to prevent...

  12. DNA damage caused by ionizing radiation

    International Nuclear Information System (INIS)

    Sachs, R.K.; Peili Chen; Hahnfeldt, P.J.; Klatky, L.R.

    1992-01-01

    A survey is given of continuous-time Markov chain models for ionizing radiation damage to the genome of mammalian cells. In such models, immediate damage induced by the radiation is regarded as a batch-Poisson arrival process of DNA double-strand breaks (DSBs). Enzymatic modification of the immediate damage is modeled as a Markov process similar to those described by the master equation of stochastic chemical kinetics. An illustrative example is the restitution/complete-exchange model. The model postulates that, after being induced by radiation, DSBs subsequently either undergo enzymatically mediated restitution (repair) or participate pairwise in chromosome exchanges. Some of the exchanges make irremediable lesions such as dicentric chromosome aberrations. One may have rapid irradiation followed by enzymatic DSB processing or have prolonged irradiation with both DSB arrival and enzymatic DSB processing continuing throughout the irradiation period. Methods for analyzing the Markov chains include using an approximate model for expected values, the discrete-time Markov chain embedded at transitions, partial differential equations for generating functions, normal perturbation theory, singular perturbation theory with scaling, numerical computations, and certain matrix methods that combine Perron-Frobenius theory with variational estimates. Applications to experimental results on expected values, variances, and statistical distributions of DNA lesions are briefly outlined. Continuous-time Markov chains are the most systematic of those radiation damage models that treat DSB-DSB interactions within the cell nucleus as homogeneous (e.g., ignore diffusion limitations). They contain virtually all other relevant homogeneous models and semiempirical summaries as special cases, limiting cases, or approximations. However, the Markov models do not seem to be well suited for studying spatial dependence of DSB interactions. 51 refs., 5 figs

  13. Environmental damage caused by fossil fuels consumption

    International Nuclear Information System (INIS)

    Barbir, F.; Veziroglu, T.N.

    1991-01-01

    This paper reports that the objectives of this study is to identify the negative effects of the fossil fuels use and to evaluate their economic significance. An economic value of the damage for each of the analyzed effects has been estimated in US dollars per unit energy of the fuel used ($/GJ). This external costs of fossil fuel use should be added to their existing market price, and such real costs should be compared with the real costs of other, environmentally acceptable, energy alternatives, such as hydrogen

  14. Damage caused to houses and equipment by underground nuclear explosions

    International Nuclear Information System (INIS)

    Delort, F.; Guerrini, C.

    1969-01-01

    A description is given of the damaged caused to various structures, buildings, houses, mechanical equipment and electrical equipment by underground nuclear explosions in granite. For each type of equipment or building are given the limiting distances for a given degree of damage. These distances have been related to a parameter characterizing the movement of the medium; it is thus possible to generalize the results obtained in granite, for different media. The problem of estimating the damage caused at a greater distance from the explosion is considered. (authors) [fr

  15. Health effects of radiation damage

    International Nuclear Information System (INIS)

    Gasimova, K; Azizova, F; Mehdieva, K.

    2012-01-01

    Full text : A summary of the nature of radiactive contamination would be incomplete without some mention of the human health effects relatied to radioactivity and radioactive materials. Several excellent reviews at the variety of levels of detail have been written and should be consulted by the reader. Internal exposures of alpha and beta particles are important for ingested and inhaled radionuclides. Dosimetry models are used to estimate the dose from internally deposited radioactive particles. As mentioned above weighting parameters that take into account the radiation type, the biological half-life and the tissue or organ at risk are used to convert the physically absorbed dose in units of gray (or red) to the biologically significant committed equivalent dose and effective dose, measured in units of Sv (or rem). There is considerable controversy over the shape of the dose-response curve at the chronic low dose levels important for enviromental contamination. Proposed models include linear models, non-linear models and threshold models. Because risks at low dose must be extrapolated from available date at high doses, the shape of the dose-response curve has important implications for the environmental regulations used to protect the general public. The health effect of radiation damage depends on a combination of events of on the cellular, tissue and systemic levels. These lead to mutations and cellular of the irradiated parent cell. The dose level at which significant damage occurs depends on the cell type. Cells that reproduce rapidily, such as those found in bone marrow or the gastrointestinal tract, will be more sensitive to radiation than those that are longer lived, such as striated muscle or nerve cells. The effects of high radiation doses on an organ depends on the various cell types it contains

  16. Lattice damage caused by the irradiation of diamond

    CERN Document Server

    Campbell, B; Mainwood, A; Newton, M; Davies, G

    2002-01-01

    Diamond is perceived to be radiation-hard, but the damage caused to the diamond is not well understood. The intrinsic defects (vacancies and interstitials) which are created by radiation damage are immobile at room temperature in diamond, unlike in silicon. Therefore, once the mechanisms of damage are understood for one type and energy of the particle, the dose and energy dependence of irradiation by other particles at a range of energies can be extrapolated. When a crystal is irradiated, the generation rates of vacancies and self-interstitials are generally determined by optical or electron paramagnetic resonance (EPR) spectroscopy experiments carried out after the irradiation has stopped. However, as the irradiation proceeds some of the carbon atoms displaced from their lattice sites may relax back into the vacant site, and the damage event will not be observed in the later measurement. In this paper, the mechanisms for radiation damage by charged particles in particular electrons and photons are investigat...

  17. Secondary damages to forests caused by industrial exhausts

    Energy Technology Data Exchange (ETDEWEB)

    Donaubauer, E

    1966-01-01

    Acute and chronic damages of diverse origins modify the susceptibility of trees to certain insects and infectious diseases. Especially in connection with air pollution damages, it must be pointed out that such predisposition may occur long before any symptoms become visible or before any growth losses can be measured. In many instances, it is very difficult to evaluate these secondary damages. Very extensive regional comparisons are necessary in order to obtain evidence of damage. Increased occurrence of parasites and/or disease within the emission area must be compared with the frequency and intensity of occurrence outside of said area; this may then serve as circumstantial proof of a demonstrated secondary damage. Examples of these kinds of effects caused by parasitic fungi and insects are discussed in detail. 27 references.

  18. Mechanical damage in cotton buds caused by the boll weevil

    Directory of Open Access Journals (Sweden)

    Santos Roseane Cavalcanti

    2003-01-01

    Full Text Available The boll weevil (Anthonomus grandis Boheman causes high levels of bud abscission in cotton plants due to feeding or oviposition punctures. It has been reported that abscission is mainly due to enzymes present in the insect's saliva, but mechanical damage could also contribute to square abscission. The objective of this paper was to undertake an analysis of the morphological damages caused by the insect in cotton squares using microscopy. Anthers and ovules are the main target of boll weevil feeding. The process initiates by perforation of young sepal and petal tissues and proceeds with subsequent alimentation on stamen and ovary leading to abscission of floral structures.

  19. Reducing environmental damages caused by transportation: towards an heterodox approach

    International Nuclear Information System (INIS)

    Marletto, Gerardo

    2006-01-01

    According to orthodox economics, monetary incentives are the best way to reduce environmental damages caused by transportation. This approach is consistent with the consideration of environmental damages as a market failure and with the use of pigouvian taxes to re-establish market equilibrium. Using heterodox economics both the theoretical and the policy approach will change radically. Indeed, market is just one of the structural components of the existing transport system; others being: institutions, technologies, values. Then, a shift in policy approaches is needed: from the orthodox efficient allocation of existing resources, to the heterodox promotion of new development patterns, needed to alter the given structural situation. Consistently with this paradigmatic shift, environmental damages caused by transportation can be reduced only by making the transition to a new transport system viable. Moreover, an heterodox approach to the reduction of environmental damages caused by transportation gives rise to a sound revision of policy tools; among these must be considered: selective industrial policies to foster the ecological reconversion of transport supply (instead of a non-discriminatory support to ecological innovations); participatory decision procedures to evaluate and select transport policies (instead of neutral technical tools - such as Cba or Eia); information campaigns based on ethical considerations (instead of economic incentives to transport demand); attribution of the status of commons to environmental resources, in order to protect them from the free riding of transport activities (instead of the attribution to them of private property rights). This essay is composed of four parts. In the first one, some data on environmental damages caused by transportation in Italy are shown. In the second one, orthodox and heterodox paradigms of public interventions in the economy are compared, with a specific attention to environmental applications. In the

  20. Economic damage caused by a nuclear reactor accident

    International Nuclear Information System (INIS)

    Goemans, T.; Schwarz, J.J.

    1988-01-01

    This study is directed towards the estimation of the economic damage which arises from a severe possible accident with a newly built 1000 MWE nuclear power plant in the Netherlands. A number of cases have been considered which are specified by the weather conditions during and the severity of the accident and the location of the nuclear power plant. For each accident case the economic damage has been estimated for the following impact categories: loss of the power plant, public health, evacuation and relocation of population, export of agricultural products, working and living in contaminated regions, decontamination, costs of transportation and incoming foreign tourism. The consequences for drinking water could not be quantified adequately. The total economic damage could reach 30 billion guilders. Besides the power plant itself, loss of export and decreasing incoming foreign tourism determine an important part of the total damage. 12 figs.; 52 tabs

  1. Careful: Acetaminophen in Pain Relief Medicines Can Cause Liver Damage

    Science.gov (United States)

    ... Pain Relievers and Fever Reducers Careful: Acetaminophen in pain relief medicines can cause liver damage Share Tweet Linkedin Pin it More sharing options Linkedin Pin ... ingredient in many over-the-counter and prescription medicines that help relieve pain and reduce fever. More than 600 over-the- ...

  2. ROCK MASS DAMAGED ZONE CAUSED BY BLASTING DURING TUNNEL EXCAVATION

    Directory of Open Access Journals (Sweden)

    Hrvoje Antičević

    2012-07-01

    Full Text Available Design of underground spaces, including tunnels, and repositories for radioactive waste include the application of the same or similar technologies. Tunnel excavation by blasting inevitably results in the damage in the rock mass around the excavation profile. The damage in the rock mass immediately next to the tunnel profile emerges as the expanding of the existing cracks and the appearance of new cracks, i.e. as the change of the physical and-mechanical properties of the rock mass. Concerning the design of deep geological repositories, requirements in terms of damaged rock are the same or more rigorous than for the design of tunnel. The aforementioned research is directed towards determining the depth of damage zone caused by blasting. The depth of the damage zone is determined by measuring the changes of physical and-mechanical properties of the rock mass around the tunnel excavation profile. By this research the drilling and blasting parameters were correlated with the depth and size of the damage zone (the paper is published in Croatian.

  3. Liability for damage caused by medical X-ray treatment

    International Nuclear Information System (INIS)

    1977-01-01

    A case of liability for damage caused by X-ray medical treatment was recently brought before the courts in Norway. Following a mistake by the physician handling the X-ray apparatus the plaintiff had received an overdose of radiation on her nose and a lengthy and expensive plastic surgery treatment had been required to repair the damage. The local court of Aalesund ruled in April 1975 that the physician concerned had committed a fault but could not be accused of gross negligence or gross fault in view of Norwegian case law on medical liability. Therefore the plaintiff obtained compensation for her medical expenses but was refused compensation for non-material damage (disfigurement and pretium doloris). (NEA) [fr

  4. Damage to underground coal mines caused by surface blasting

    International Nuclear Information System (INIS)

    Fourie, A.B.; Green, R.W.

    1993-01-01

    An investigation of the potential damage to underground coal workings as a result of surface blasting at an opencast coal mine is described. Seismometers were installed in a worked out area of an underground mine, in the eastern Transvaal region of South Africa, and the vibration caused by nearby surface blasting recorded. These measurements were used to derive peak particle velocities. These velocities were correlated with observed damage underground in order to establish the allowable combination of the two blasting parameters of charge mass per relay, and blast-to-gage point distance. An upper limit of 110mm/sec peak particle velocity was found to be sufficient to ensure that the damage to the particular workings under consideration was minimal. It was further found that a cube-root scaling law provided a better fit to the field data than the common square-root law. 11 refs., 6 figs., 5 tabs

  5. Compensation for the damage caused by the Chernobyl disaster

    International Nuclear Information System (INIS)

    Joirysch, A.; Supataeva, O.

    1993-01-01

    The teachings of the accident at the nuclear power plant of Chernobyl clearly showed that the existing rules of Russian legislation cannot handle the problems in respect of civil liability for nuclear damage. This paper describes how the Soviet State and Soviet law tried to cope with the question of compensation for damage to human health and property in a special legal situation, due to the lack of any particular legislation covering this area and to the fact that the USSR is a Party neither to the Vienna nor the Paris Convention. In 1991 a law of the Russian Federation 'On the social protection of citizens who suffered as a consequence of the Chernobyl disaster' established a State system of services and compensation for such damage and the procedure for financing was laid down by a ministerial letter. 4 refs

  6. DNA damage caused by UV- and near UV-irradiation

    International Nuclear Information System (INIS)

    Ohnishi, Takeo

    1986-01-01

    Much work with mutants deficient in DNA repair has been performed concerning UV-induced DNA damage under the condition where there is no artificial stimulation. In an attempt to infer the effects of solar wavelengths, the outcome of the work is discussed in terms of cellular radiation sensitivity, unscheduled DNA synthesis, and mutation induction, leading to the conclusion that some DNA damage occurs even by irradiation of the shorter wavelength light (270 - 315 nm) and is repaired by excision repair. It has been thought to date that pyrimidine dimer (PD) plays the most important role in UV-induced DNA damage, followed by (6 - 4) photoproducts. As for DNA damage induced by near UV irradiation, the yield of DNA single-strand breaks and of DNA-protein crosslinking, other than PD, is considered. The DNA-protein crosslinking has proved to be induced by irradiation at any wavelength of UV ranging from 260 to 425 nm. Near UV irradiation causes the inhibition of cell proliferation to take place. (Namekawa, K.)

  7. Compensation of damage to the environment caused by industrial catastrophes

    International Nuclear Information System (INIS)

    Smets, H.

    1986-01-01

    Industrial accidents have caused considerable damage to the environment and the author reviews third party liability systems and insurance in the different countries concerned. He considers that indemnification of major accidents costing between 50 millions and several billions French francs requires the setting up of an elaborate system which makes provision for high amounts. The most dangerous activities in the oil and chemical sectors should be subject to special requirements regarding insurance or financial security patterned on the system for nuclear installations. (NEA) [fr

  8. [Causes and management of severe acute liver damage during pregnancy].

    Science.gov (United States)

    Sepulveda-Martinez, Alvaro; Romero, Carlos; Juarez, Guido; Hasbun, Jorge; Parra-Cordero, Mauro

    2015-05-01

    Abnormalities in liver function tests appear in 3% of pregnancies. Severe acute liver damage can be an exclusive condition of pregnancy (dependent or independent of pre-eclampsia) or a concomitant disease. HELLP syndrome and acute fatty liver of pregnancy are the most severe liver diseases associated with pregnancy. Both appear during the third trimester and have a similar clinical presentation. Acute fatty liver may be associated with hypoglycemia and HELLP syndrome is closely linked with pre-eclampsia. Among concomitant conditions, fulminant acute hepatitis caused by medications or virus is the most severe disease. Its clinical presentation may be hyper-acute with neurological involvement and severe coagulation disorders. It has a high mortality and patients should be transplanted. Fulminant hepatic failure caused by acetaminophen overdose can be managed with n-acetyl cysteine. Because of the high fetal mortality rate, the gestational age at diagnosis is crucial.

  9. Climatology of damage-causing hailstorms over Germany

    Science.gov (United States)

    Kunz, M.; Puskeiler, M.; Schmidberger, M.

    2012-04-01

    In several regions of Central Europe, such as southern Germany, Austria, Switzerland, and northern Italy, hailstorms often cause substantial damage to buildings, crops, or automobiles on the order of several million EUR. In the federal state of Baden-Württemberg, for example, most of the insured damage to buildings is caused by large hailstones. Due to both their local-scale extent and insufficient direct monitoring systems, hail swaths are not captured accurately and uniquely by a single observation system. Remote-sensing systems such as radars are able to detect convection signals in a basic way, but they lack the ability to discern a clear relation between measured intensity and hail on the ground. These shortcomings hamper statistical analysis on the hail probability and intensity. Hail modelling thus is a big challenge for the insurance industry. Within the project HARIS-CC (Hail Risk and Climate Change), different meteorological observations are combined (3D / 2D radar, lightning, satellite and radiosounding data) to obtain a comprehensive picture of the hail climatology over Germany. The various approaches were tested and calibrated with loss data from different insurance companies between 2005 and 2011. Best results are obtained by considering the vertical distance between the 0°C level of the atmosphere and the echo top height estimated from 3D reflectivity data from the radar network of German Weather Service (DWD). Additionally, frequency, intensity, width, and length of hail swaths are determined by applying a cell tracking algorithm to the 3D radar data (TRACE3D; Handwerker, 2002). The hailstorm tracks identified are merged with loss data using a geographical information system (GIS) to verify damage-causing hail on the ground. Evaluating the hailstorm climatology revealed that hail probability exhibits high spatial variability even over short distances. An important issue is the spatial pattern of hail occurrence that is considered to be due to

  10. Bone marrow scintigraphy: evaluation of damage caused by cancer chemotherapy

    International Nuclear Information System (INIS)

    Ciambellotti, E.; Cartia, G.L.; Coda, C.

    1988-01-01

    For various reasons the well-known myelopoietic damage caused by cancer chemotherapy is not easy to quantify by means of usual diagnostic procedures. The bone marrow scan with 99m Tc-nanocolloid rapidly cleared by the phagocitic action of the RES, which has a topographic extension similar to red marrow, has been used for many years to evaluate the inflammatory and neoplastic diseases, both localized and diffuse. Such examination was thus performed in patients undergoing cytostatic therapy, either to follow-up metastatic lesions or to evaluate a tissue damage due to different drugs. The BMS is easily performed and has no side-effects. It consists of a dinamic and a static part. Moreover, it helped pointing out important diagnostic data, such as the reduction of the sacroiliac uptake index below the normal values (3.7) in 33 out of 57 cases, and an abnormal distribution of nanocolloid in the skeleton (Munz's classification, 1983) in 37 out of 69 cases, higher in more myelotoxic cytostatic, which could be detected even after a few months

  11. Electron beam deposition system causing little damage to organic layers

    Energy Technology Data Exchange (ETDEWEB)

    Yamada, Minoru [Research Center for Solar Energy Chemistry, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531 (Japan); Business Incubation Department, Hitachi Zosen Corporation, 2-11 Funamachi 2-Chome, Taisho-ku, Osaka 551-0022 (Japan); Matsumura, Michio, E-mail: matsu@chem.es.osaka-u.ac.jp [Research Center for Solar Energy Chemistry, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531 (Japan); Maeda, Yasuhiro [Business Incubation Department, Hitachi Zosen Corporation, 2-11 Funamachi 2-Chome, Taisho-ku, Osaka 551-0022 (Japan)

    2011-07-29

    Conditions for deposition of an aluminum (Al) layer on an organic light-emitting layer with an electron beam (EB) deposition system were optimized with respect to deposition rate and damage to organic layers. The damage to the organic layers was found to be mostly caused by X-rays emitted from a target bombarded with accelerated electrons. In order to decrease the X-ray intensity while maintaining a high deposition rate, we used an EB source which emits high-density EB at low acceleration voltage. In addition, we inserted a heat reflector and a sintered-carbon liner between the Al target and copper crucible to improve heat insulation. As a result, the voltage needed for the deposition of Al electrodes at a rate of about 8 nm/s was lowered from normal voltages of 2.0 kV or higher to as low as 1.5 kV. To reduce the number of electrons hitting the substrate, we set pole pieces near the target and an electron trap in the chamber. The devices on which Al electrodes were deposited with the EB system showed almost the same properties as those of devices on which the Al electrodes were deposited by a resistive-heating method.

  12. [Study on sperm damage caused by trichloroethylene in male rats].

    Science.gov (United States)

    Wu, De-sheng; Yang, Lin-qing; Huang, Sui; Liu, Jian-jun; Xu, Xin-yun; Huang, Hai-yan; Gong, Chun-mei; Hu, Gong-hua; Liu, Qing-cheng; Yang, Xi-fei; Hong, Wen-xu; Zhou, Li; Huang, Xin-feng; Yuan, Jian-hui; Zhuang, Zhi-xiong

    2013-11-01

    To study in vitro sperm damage caused by trichloroethylene in male rats. Sperms of Sprague-Dawley (SD) rats were collected 4 hours after being contaminated by trichloroethylene of 0, 2, 4, 6, 8, and 10 mmol/L in vitro. Giemsa staining was performed to observe the morphological changes of sperms, and flow cytometer was used to detect the changes in mitochondrial membrane potential. The sperm motilities in 6, 8, and 10 mmol/L trichloroethylene groups decreased significantly compared with that in control group (P trichloroethylene groups were significantly higher than that in control group (Ptrichloroethylene groups and control group (Ptrichloroethylene can reduce sperm motility and increase the aberration rate and apoptosis rate of sperms in male SD rats.

  13. Chronic occupational exposure to hexavalent chromium causes DNA damage in electroplating workers.

    Science.gov (United States)

    Zhang, Xu-Hui; Zhang, Xuan; Wang, Xu-Chu; Jin, Li-Fen; Yang, Zhang-Ping; Jiang, Cai-Xia; Chen, Qing; Ren, Xiao-Bin; Cao, Jian-Zhong; Wang, Qiang; Zhu, Yi-Min

    2011-04-12

    Occupational exposure to chromium compounds may result in adverse health effects. This study aims to investigate whether low-level hexavalent chromium (Cr(VI)) exposure can cause DNA damage in electroplating workers. 157 electroplating workers and 93 control subjects with no history of occupational exposure to chromium were recruited in Hangzhou, China. Chromium levels in erythrocytes were determined by graphite furnace atomic absorption spectrophotometer. DNA damage in peripheral lymphocytes was evaluated with the alkaline comet assay by three parameters: Olive tail moment, tail length and percent of DNA in the comet tail (tail DNA%). Urinary 8-OHdG levels were measured by ELISA. Chromium concentration in erythrocytes was about two times higher in electroplating workers (median: 4.41 μg/L) than that in control subjects (1.54 μg/L, P electroplating workers. Low-level occupational chromium exposure induced DNA damage.

  14. Plasmid DNA damage caused by stibine and trimethylstibine

    International Nuclear Information System (INIS)

    Andrewes, Paul; Kitchin, Kirk T.; Wallace, Kathleen

    2004-01-01

    Antimony is classified as 'possibly carcinogenic to humans' and there is also sufficient evidence for antimony carcinogenicity in experimental animals. Stibine is a volatile inorganic antimony compound to which humans can be exposed in occupational settings (e.g., lead-acid battery charging). Because it is highly toxic, stibine is considered a significant health risk; however, its genotoxicity has received little attention. For the work reported here, stibine was generated by sodium borohydride reduction of potassium antimony tartrate. Trimethylstibine is a volatile organometallic antimony compound found commonly in landfill and sewage fermentation gases at concentrations ranging between 0.1 and 100 μg/m 3 . Trimethylstibine is generally considered to pose little environmental or health risk. In the work reported here, trimethylstibine was generated by reduction of trimethylantimony dichloride using either sodium borohydride or the thiol compounds, dithioerythritol (DTE), L-cysteine, and glutathione. Here we report the evaluation of the in vitro genotoxicities of five antimony compounds--potassium antimony tartrate, stibine, potassium hexahydroxyantimonate, trimethylantimony dichloride, and trimethylstibine--using a plasmid DNA-nicking assay. Of these five antimony compounds, only stibine and trimethylstibine were genotoxic (significant nicking to pBR 322 plasmid DNA). We found stibine and trimethylstibine to be about equipotent with trimethylarsine using this plasmid DNA-nicking assay. Reaction of trimethylantimony dichloride with either glutathione or L-cysteine to produce DNA-damaging trimethylstibine was observed with a trimethylantimony dichloride concentration as low as 50 μM and L-cysteine or glutathione concentrations as low as 500 and 200 μM, respectively, for a 24 h incubation

  15. Characterization of genetic miscoding lesions caused by postmortem damage

    DEFF Research Database (Denmark)

    Gilbert, M Thomas P; Hansen, Anders J; Willerslev, Eske

    2002-01-01

    The spectrum of postmortem damage in mitochondrial DNA was analyzed in a large data set of cloned sequences from ancient human specimens. The most common forms of damage observed are two complementary groups of transitions, termed "type 1" (adenine-->guanine/thymine-->cytosine) and "type 2...

  16. Electrocautery causes more ischemic peritoneal tissue damage than ultrasonic dissection.

    NARCIS (Netherlands)

    Broek, R.P.G ten; Wilbers, J.; Goor, H. van

    2011-01-01

    BACKGROUND: Minimizing peritoneal tissue injury during abdominal surgery has the benefit of reducing postoperative inflammatory response, pain, and adhesion formation. Ultrasonic dissection seems to reduce tissue damage. This study aimed to compare electrocautery and ultrasonic dissection in terms

  17. KEKB facility damage caused by the Great East Japan Earthquake

    International Nuclear Information System (INIS)

    Ono, Masaaki

    2011-01-01

    As shown in photos, severe damages were observed at several facilities in Tsukuba campus, including the infrastructure, especially at the ground - weakened area. KEKB also damaged facility has been under the upgrade stage to SuperKEKB. So works for disassembling of KEKB machine and for remodeling of the equipment were undertaken. Fortunately no one was injured but the situations were quite hazardous. KEKB ring set ∼13m below the ground also experienced the severe tremors. All expansion points were injured and the cracks on the ceiling/wall/floor were created around the ring, but significant damage such as the tunnel destruction was not observed. Repairs were started, and resumed possible SuperKEKB construction though it will delay 2-3 months. (author)

  18. Local damage to reinforced concrete structures caused by impact of aircraft engine missiles. Pt. 1

    International Nuclear Information System (INIS)

    Sugano, T.; Tsubota, H.; Kasai, Y.; Koshika, N.; Ohnuma, H.; Von Riesemann, W.A.; Bickel, D.C.; Parks, M.B.

    1993-01-01

    Structural damage induced by an aircraft crashing into a reinforced concrete structure includes local damage caused by the deformable engines, and global damage caused by the entire aircraft. Local damage to the target may consist of spalling of concrete from its front face together with missile penetration into it, scabbing of concrete from its rear face, and perforation of missile through it. Until now, local damage to concrete structures has been mainly evaluated by rigid missile impact tests. Past research work regarding local damage caused by impact of deformable missiles has been limited. This paper presents the results of a series of impact tests of small-, intermediate-, and full-scale engine models into reinforced concrete panels. The purpose of the tests was to determine the local damage to a reinforced concrete structure caused by the impact of a deformable aircraft engine. (orig.)

  19. Repair of radiation damage caused by cyclotron-produced neutrons

    International Nuclear Information System (INIS)

    Martins, B.I.

    1979-01-01

    Hall et al. present experimental data on repair of sublethal damage in cultured mammalian cells exposed to 35 MeV neutrons and 60 Co γ rays. Hall and Kraljevic present experimental data on repair of potentially lethal damage in cultured mammalian cells exposed to 35 MeV neutrons and 210 kVp x rays. These results of Hall et al. are very difficult to explain from basic concepts in radiobiology. Contrary to Rossi, these data do not support his thesis that repair of radiation damage is dose-dependent and linear energy transfer independent. Nor do these results meet the expectations of multitarget-single hit theory which would require dose-independent repair equal to n. The observation of the same extrapolation number for neutrons and for x rays is also surprising. From the point of view of radiotherapy, the doses of interest are about 140 rad for neutrons and about 300 rad for x rays. There are no data for repair of potentially lethal damage below 800 rad for x rays and 400 rad for neutrons. The difference in survival between single and split dose is negligible up to a total of about 600 rad of x rays or of neutrons. These data of Hall et al. therefore have little significance to radiotherapists and are an enigma to radiobiologists

  20. Cytomegalovirus-Induced Effector T Cells Cause Endothelial Cell Damage

    NARCIS (Netherlands)

    van de Berg, Pablo J. E. J.; Yong, Si-La; Remmerswaal, Ester B. M.; van Lier, René A. W.; ten Berge, Ineke J. M.

    2012-01-01

    Human cytomegalovirus (CMV) infection has been linked to inflammatory diseases that involve vascular endothelial cell damage, but definitive proof for a direct cytopathic effect of CMV in these diseases is lacking. CMV infection is associated with a strong increase in both CD4(+) and CD8(+) T cells

  1. Oxidative DNA damage causes mitochondrial genomic instability in Saccharomyces cerevisiae.

    Science.gov (United States)

    Doudican, Nicole A; Song, Binwei; Shadel, Gerald S; Doetsch, Paul W

    2005-06-01

    Mitochondria contain their own genome, the integrity of which is required for normal cellular energy metabolism. Reactive oxygen species (ROS) produced by normal mitochondrial respiration can damage cellular macromolecules, including mitochondrial DNA (mtDNA), and have been implicated in degenerative diseases, cancer, and aging. We developed strategies to elevate mitochondrial oxidative stress by exposure to antimycin and H(2)O(2) or utilizing mutants lacking mitochondrial superoxide dismutase (sod2Delta). Experiments were conducted with strains compromised in mitochondrial base excision repair (ntg1Delta) and oxidative damage resistance (pif1Delta) in order to delineate the relationship between these pathways. We observed enhanced ROS production, resulting in a direct increase in oxidative mtDNA damage and mutagenesis. Repair-deficient mutants exposed to oxidative stress conditions exhibited profound genomic instability. Elimination of Ntg1p and Pif1p resulted in a synergistic corruption of respiratory competency upon exposure to antimycin and H(2)O(2). Mitochondrial genomic integrity was substantially compromised in ntg1Delta pif1Delta sod2Delta strains, since these cells exhibit a total loss of mtDNA. A stable respiration-defective strain, possessing a normal complement of mtDNA damage resistance pathways, exhibited a complete loss of mtDNA upon exposure to antimycin and H(2)O(2). This loss was preventable by Sod2p overexpression. These results provide direct evidence that oxidative mtDNA damage can be a major contributor to mitochondrial genomic instability and demonstrate cooperation of Ntg1p and Pif1p to resist the introduction of lesions into the mitochondrial genome.

  2. Damages to gladiolu corm caused by fast neutron irradiation

    International Nuclear Information System (INIS)

    Zhang Zhiwei; Wang Dan; Zhang Dongxue; Zheng Chun

    2007-01-01

    Gladiolus corms were irradiated to 100-500kGy by fast neutrons in the CFBR-II pulsed reactor, Scanning electron microscope images of the irradiated samples revealed significant radiation damages to the gladiolus corms, and the mutagenic effects were studied by SDS-polyacrylamide gel electrophoresis (SDS-PAGE). Within the dose range, radiation damage to the corm increased with the dose, with corm epidermis of the samples irradiated in vertical incidence being more serious than those irradiated in side-incidence to the same dose. Biological characters were investigated via field experiments, and the bands of protein subunit were analyzed by SDS-PAGE. The results showed that the fast neutrons irradiation inhibited growth of M1 generation seedling significantly. Protein expression was obviously inhibited by the irradiation. The study indicates that fast neutron induction is an effective way for gladiolus breeding. And the results may lay a foundation for studies on fast neutron mutation breeding. (authors)

  3. Interventions for skin changes caused by nerve damage in leprosy

    Directory of Open Access Journals (Sweden)

    Liv Merete Reinar

    Full Text Available BACKGROUND More than three million persons are disabled by leprosy worldwide. The main complication of sensory nerve damage is neuropathic ulceration, particularly of the feet. In this review we explored interventions that can prevent and treat secondary damage to skin and limbs. OBJECTIVE To assess the effects of self-care, dressings and footwear in preventing and healing secondary damage to the skin in persons affected by leprosy. METHODS Search methods: We searched the Cochrane Skin Group Specialised Register (April 2008, the Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 1, 2008, MEDLINE (from 2003 to April 2008, EMBASE (from 2005 to April 2008, CINAHL (1982-2006 and LILACS (1982- April 2008 as well as online registers of ongoing trials (April 2008. Selection criteria: Randomised controlled trials involving anyone with leprosy and damage to peripheral nerves treated with any measures designed to prevent damage with the aim of healing existing ulcers and preventing development of new ulcers. Data collection and analysis: Two authors assessed trial quality and extracted data. MAIN RESULTS Eight trials with a total of 557 participants were included. The quality of the trials was generally poor. The interventions and outcome measures were diverse. Although three studies that compared zinc tape to more traditional dressings found some benefit, none of these showed a statistically significant effect. One trial indicated that topical ketanserin had a better effect on wound healing than clioquinol cream or zinc paste, RR was 6.00 (95% CI 1.45 to 24.75. We did not combine the results of the two studies that compared topical phenytoin to saline dressing, but both studies found statistically significant effects in favour of phenytoin for healing of ulcer (SMD -2.34; 95% CI -3.30 to -1.39; and SMD -0.79; 95% CI -1.20 to 0.39. Canvas shoes were not much better than PVC-boots, and double rocker shoes did not promote healing

  4. Interventions for skin changes caused by nerve damage in leprosy.

    Science.gov (United States)

    Reinar, Liv Merete; Forsetlund, Louise; Bjørndal, Arild; Lockwood, Diana

    2008-07-16

    More than three million persons are disabled by leprosy worldwide. The main complication of sensory nerve damage is neuropathic ulceration, particularly of the feet. In this review we explored interventions that can prevent and treat secondary damage to skin and limbs. To assess the effects of self-care, dressings and footwear in preventing and healing secondary damage to the skin in persons affected by leprosy. We searched the Cochrane Skin Group Specialised Register (April 2008), the Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 1, 2008), MEDLINE (from 2003 to April 2008), EMBASE (from 2005 to April 2008), CINAHL (1982-2006) and LILACS (1982- April 2008 ) as well as online registers of ongoing trials (April 2008). Randomised controlled trials involving anyone with leprosy and damage to peripheral nerves treated with any measures designed to prevent damage with the aim of healing existing ulcers and preventing development of new ulcers. Two authors assessed trial quality and extracted data. Eight trials with a total of 557 participants were included. The quality of the trials was generally poor. The interventions and outcome measures were diverse. Although three studies that compared zinc tape to more traditional dressings found some benefit, none of these showed a statistically significant effect. One trial indicated that topical ketanserin had a better effect on wound healing than clioquinol cream or zinc paste, RR was 6.00 (95% CI 1.45 to 24.75). We did not combine the results of the two studies that compared topical phenytoin to saline dressing, but both studies found statistically significant effects in favour of phenytoin for healing of ulcer (SMD -2.34; 95% CI -3.30 to -1.39; and SMD -0.79; 95% CI -1.20 to 0.39). Canvas shoes were not much better than PVC-boots, and double rocker shoes did not promote healing much more than below-knee plasters. One study suggested that topical ketanserin is more effective than clioquinol cream

  5. Three model systems measure oxidation/nitration damage caused ...

    Indian Academy of Sciences (India)

    Unknown

    caused by peroxynitrite ... (OONO–) or its carbon dioxide derivatives cause oxidation/nitration and hence mutation to various body poly- mers e.g. .... The work described in this paper is quite brief due to ex- ... exact way to balance the dose of antioxidants in mixtures ... tralizing conditions the half-life of OONO– is less than.

  6. Compensation of damage caused by diverted nuclear substances

    International Nuclear Information System (INIS)

    Deprimoz, J.

    1981-10-01

    This paper provides a comprehensive analysis of the insurance system for nuclear liability. As a rule, if nuclear fuel, radioactive products or waste are governed by nuclear energy law providing for strict and channelled liability, their legal holder will pay for damage arising from them anywhere within 20 years after theft or diversion and 10 years after the nuclear incident. In most countries, atomic liability insurers will implicitly grant their cover through policies underwritten by legal holders. If diverted substances have a low specific radioactivity, their legal holder remains liable according to common law and insurance policies cover this conventional liability. (NEA) [fr

  7. 76 FR 44985 - Pipeline Safety: Potential for Damage to Pipeline Facilities Caused by Flooding

    Science.gov (United States)

    2011-07-27

    .... PHMSA-2011-0177] Pipeline Safety: Potential for Damage to Pipeline Facilities Caused by Flooding AGENCY... liquid pipelines to communicate the potential for damage to pipeline facilities caused by severe flooding... pipelines in case of flooding. ADDRESSES: This document can be viewed on the Office of Pipeline Safety home...

  8. Mechanical injuries, burns and combination damage caused by reactor accidents

    International Nuclear Information System (INIS)

    Koslowski, L.

    1981-01-01

    In cases of combination damage the initial treatment of wounds is the same as with injuries without accompanying radiation exposure. In the beginning the general principles of surgical treatment apply. In case of a mass accident, the examination of the injured to decide on the necessary kind of treatment has priority. A common problem to all the decisions is that the extent of a radiation exposure that may have been sustained cannot be established at once. Whether the radiation exposure has been so heavy as to require the modification of the surgical measures can be seen only from the blood count, the bone marrow biopsy, the reticulocyte count or from a chromosome analysis. (DG) [de

  9. Neuronal Rat Brain Damage Caused by Endogenous and Exogenous Hyperthermia

    Directory of Open Access Journals (Sweden)

    Mustafa Aydın

    2012-03-01

    Full Text Available OBJECTIVE: Hyperthermia may induce pathologic alterations within body systems and organs including brain. In this study, neuronal effects of endogenous and exogenous hyperthermia (41°C were studied in rats. METHODS: The endogenous hyperthermia (41°C was induced by lipopolysaccharide and the exogenous by an (electric heater. Possible neuronal damage was evaluated by examining healthy, apoptotic and necrotic cells, and heat shock proteins (HSP 27, HSP 70 in the cerebral cortex, cerebellum and hypothalamus RESULTS: At cellular level, when all neuronal tissues are taken into account; (i a significant increase in the necrotic cells was observed in the both groups (p0.05. CONCLUSION: The neural tissue of brain can show different degree of response to hyperthermia. But we can conclude that endogenous hyperthermia is more harmful to central nervous system than exogenous hyperthermia

  10. Damage on sliding bearings of internal combustion engines. Damage patterns, causes, prevention; Schaeden an Gleitlagern von Verbrennungsmotoren. Erscheinungsbilder, Ursachen, Vermeidung

    Energy Technology Data Exchange (ETDEWEB)

    Ederer, U.G. [Miba Gleitlager GmbH, Laakrichen (Austria)

    2005-07-01

    Bearing failures are consequences of system deficiencies which cause an inadequate function of the hydrodynamic action and, thereby, too high a friction, at least locally. The bearing overheats, what ultimately leads to its destruction and that of adjacent components. These 'consequential damages' are frequently severe. We identify, therefore, early stages of malfunction, already as 'bearing damage'. In this condition, a diagnosis and remedial measures to avoid total destruction are possible. Typical bearing conditions, possible causes and remedies are described herein. (orig.)

  11. Chronic occupational exposure to hexavalent chromium causes DNA damage in electroplating workers

    Directory of Open Access Journals (Sweden)

    Ren Xiao-Bin

    2011-04-01

    Full Text Available Abstract Background Occupational exposure to chromium compounds may result in adverse health effects. This study aims to investigate whether low-level hexavalent chromium (Cr(VI exposure can cause DNA damage in electroplating workers. Methods 157 electroplating workers and 93 control subjects with no history of occupational exposure to chromium were recruited in Hangzhou, China. Chromium levels in erythrocytes were determined by graphite furnace atomic absorption spectrophotometer. DNA damage in peripheral lymphocytes was evaluated with the alkaline comet assay by three parameters: Olive tail moment, tail length and percent of DNA in the comet tail (tail DNA%. Urinary 8-OHdG levels were measured by ELISA. Results Chromium concentration in erythrocytes was about two times higher in electroplating workers (median: 4.41 μg/L than that in control subjects (1.54 μg/L, P P P P Conclusion The findings in this study indicated that there was detectable chromium exposure in electroplating workers. Low-level occupational chromium exposure induced DNA damage.

  12. Local damage to reinforced concrete structures caused by impact of aircraft engine missiles. Pt. 2

    International Nuclear Information System (INIS)

    Sugano, T.; Tsubota, H.; Kasai, Y.; Koshika, N.; Itoh, C.; Shirai, K.; Von Riesemann, W.A.; Bickel, D.C.; Parks, M.B.

    1993-01-01

    Three sets of impact tests, small-, intermediate-, and full-scale tests, have been executed to determine local damage to reinforced concrete structures caused by the impact of aircraft engine missiles. The results of the test program showed that (1) the use of the similarity law is appropriate, (2) suitable empirical formulas exist for predicting the local damage caused by rigid missiles, (3) reduction factors may be used for evaluating the reduction in local damage due to the deformability of the engines, (4) the reinforcement ratio has no effect on local damage, and (5) the test results could be adequately predicted using nonlinear response analysis. (orig.)

  13. Mouse skin damages caused by fractionated irradiation with carbon ions

    Energy Technology Data Exchange (ETDEWEB)

    Ando, K; Chen, Y J; Ohira, C; Nojima, K; Ando, S; Kobayashi, N; Ohbuchi, T; Shimizu, W [Space and Particle Radiation Science Research Group, Chiba (Japan); Koike, S; Kanai, T [National Inst. of Radiological Sciences, Chiba (Japan). Div. of Accelerator Physics

    1997-09-01

    We have investigated carbon-dose responses of early and late skin damages after daily fractionations to the mouse leg. Depilated legs were irradiated with 7 different positions within 290 MeV/u carbon beams. Fractionation schedules were 1, 2, 4 and 8 daily fractions. Skin reaction was scored every other day for 32 days. Five highest scores in individual mice were averaged, and used as averaged peak reaction. The isoeffect doses to produce an averaged peak skin reaction of 3.0 (moist desquamation) on dose-response curves were calculated with 95% confidence limit. The isoeffect dose for control gamma rays constantly increased with an increase in the number of fraction. The isoeffect doses in low LET carbon ions of 14- and 20 keV/{mu}m also increased up to 4 fractions, but did not increase when 4 fractions increased to 8 fractions. The saturation of isoeffect dose was more prominently observed for 40 keV/{mu}m in such that the isoeffect doses did not change among 2, 4 and 8 fractions. The isoeffect doses for LET higher than 50 keV/{mu}m were smaller than those for lower LET. However, the isoeffect doses for 50-, 60-, 80- and 100 keV/{mu} steadily increased with an increase in the number of fraction and did not show any saturation up to 8 fractions. Relation between LET and RBE was linear for all fractionation schedules. The slope of regression line in 4 fractions was steepest, and significantly (P<0.05) different from that in 1 fraction. (orig.)

  14. Mouse skin damages caused by fractionated irradiation with carbon ions

    International Nuclear Information System (INIS)

    Ando, K.; Chen, Y.J.; Ohira, C.; Nojima, K.; Ando, S.; Kobayashi, N.; Ohbuchi, T.; Shimizu, W.; Koike, S.; Kanai, T.

    1997-01-01

    We have investigated carbon-dose responses of early and late skin damages after daily fractionations to the mouse leg. Depilated legs were irradiated with 7 different positions within 290 MeV/u carbon beams. Fractionation schedules were 1, 2, 4 and 8 daily fractions. Skin reaction was scored every other day for 32 days. Five highest scores in individual mice were averaged, and used as averaged peak reaction. The isoeffect doses to produce an averaged peak skin reaction of 3.0 (moist desquamation) on dose-response curves were calculated with 95% confidence limit. The isoeffect dose for control gamma rays constantly increased with an increase in the number of fraction. The isoeffect doses in low LET carbon ions of 14- and 20 keV/μm also increased up to 4 fractions, but did not increase when 4 fractions increased to 8 fractions. The saturation of isoeffect dose was more prominently observed for 40 keV/μm in such that the isoeffect doses did not change among 2, 4 and 8 fractions. The isoeffect doses for LET higher than 50 keV/μm were smaller than those for lower LET. However, the isoeffect doses for 50-, 60-, 80- and 100 keV/μ steadily increased with an increase in the number of fraction and did not show any saturation up to 8 fractions. Relation between LET and RBE was linear for all fractionation schedules. The slope of regression line in 4 fractions was steepest, and significantly (P<0.05) different from that in 1 fraction. (orig.)

  15. Understanding transportation-caused rangeland damage in Mongolia.

    Science.gov (United States)

    Keshkamat, S S; Tsendbazar, N E; Zuidgeest, M H P; Shiirev-Adiya, S; van der Veen, A; van Maarseveen, M F A M

    2013-01-15

    Mongolia, a vast and sparsely populated semi-arid country, has very little formal road infrastructure. Since the 1990s, private ownership and usage of vehicles has been increasing, which has created a web of dirt track corridors due to the communal land tenure and unobstructed terrain, with some of these corridors reaching over 4 km in width. This practice aids wind- and water-aided erosion and desertification, causing enormous negative environmental effects. Little is being done to counter the phenomenon, mainly because the logic of the driving behaviour that causes this dirt road widening is not fully understood. The research in this article postulates that this driving behaviour has rational foundations and is linked to various geographical factors (natural and man-made geographical features). We analysed 11,000 km of arterial routes in the country using spatial statistics and determined that geographically weighted regression (GWR) analysis offers a good explanation for whether, and by how much, the selected geographical factors affect the creation of corridor widths and how their effect varies across the landscape. We determined that corridor widths are correlated to factors such as proximity to river crossings, traffic intensity, and vegetation abundance. Knowing these factors can help local planners and engineers design counter-measures that could help to control and reduce the widths of these corridors, until paved roads can replace the dirt track corridors. Copyright © 2012 Elsevier Ltd. All rights reserved.

  16. Evaluation of the damages in rocks caused by the construction of a repository

    International Nuclear Information System (INIS)

    Devillers, C.; Escalier des Orres, P.

    1988-12-01

    The Commissariat a l'Energie Atomique (French Atomic Energy Commission) has conducted a bibliographic study of the damages in the rock caused by the construction of a repository, and several hydraulic simulations, to appreciate the influence of these damages on the safety of the repository. These studies have led to the proposal of construction techniques in accordance safety requirements and industrial feasibility [fr

  17. An observation of histological evidence on internal organ damages in mice caused by repeated exposures to motorcycle emissions

    Science.gov (United States)

    Wardoyo, Arinto Y. P.; Juswono, Unggul P.; Noor, Johan A. E.

    2017-05-01

    Motor vehicle emissions have been identified as a source of ultrafine particles, which have significant impacts on human health. Repeated and prolonged exposure to ultrafine particles may have a significant association with organ damage. Here, we evaluated the correlation between repeated exposure to ultrafine particles and organ damage in mice. Motorcycle emissions were injected into an exposure chamber with mice for a period of 20 seconds. This treatment was conducted over 10 days. The mice were sacrificed on the 2nd, 4th, 6th, 8th, and 10th days for organ preparations. Based on the results, motorcycle emission exposure caused organ damage in mice, with different severities depending on the organ. The highest damage was found for the lung, followed by the kidney, erythrocytes, and liver.

  18. 78 FR 41991 - Pipeline Safety: Potential for Damage to Pipeline Facilities Caused by Flooding

    Science.gov (United States)

    2013-07-12

    ... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No...: Pipeline and Hazardous Materials Safety Administration (PHMSA); DOT. ACTION: Notice; Issuance of Advisory... Gas and Hazardous Liquid Pipeline Systems. Subject: Potential for Damage to Pipeline Facilities Caused...

  19. The classification, recording, databasing and use of information about building damage caused by subsidence and landslides

    OpenAIRE

    Cooper, Anthony

    2008-01-01

    Building damage as a result of subsidence and lateral movement can be caused by numerous mechanisms including mining, dissolution of soluble rocks, shrink–swell of clays and landslides. In many instances, the distribution and severity of the damage caused can be diagnostic of the underlying geological condition and can be used as an aid to geological and geomorphological mapping. Many rigid buildings are sensitive to movement, meaning that careful surveys can delineate fine details that can b...

  20. Effect of low dose pre-irradiation on DNA damage and genetic material damage caused by high dosage of cyclophosphamide

    International Nuclear Information System (INIS)

    Yu Hongsheng; Zhu Jingjuan; Shang Qingjun; Wang Zhuomin; Cui Fuxian

    2007-01-01

    Objective: To study the effect of low dose γ-rays pre-irradiation on the induction of DNA damage and genetic material damage in peripheral lymphocytes by high dosage of cyclophosphamide (CTX). Methods: Male Kunming strain mice were randomly divided into five groups: control group, sham-irradiated group, low dose irradiated group(LDR group), cyclophosphamide chemotherapy group(CTX group) and low dose irradiation combined with chemotherapy group(LDR + CTX group). After being feeded for one week, all the mice were implanted subcutaneously with S180 cells in the left groin (control group excluded). On days 8 and 11, groups of LDR and LDR + CTX were administered with 75 mGy of whole-body irradiation, 30 h later groups CTX and LDR + CTX were injected intraperitoneally 3.0 mg cyclophosphamide. All the mice were sacrificed on day 13. DNA damage of the peripheral lymphocytes was analyzed using single cell gel electrophoresis (SCGE). Genetic material damage was analyzed using micronucleus frequency(MNF) of polychromatoerythrocytes(PCE) in bone marrow. Results: (1) Compared with control group and sham-irradiated group, the DNA damage of peripheral lymphocytes in CTX group were increased significantly (P 0.05). Conclusions: (1) High- dosage of CTX chemotherapy can cause DNA damage in peripheral lymphocytes. 75 mGy y-irradiation before chemotherapy may have certain protective effect on DNA damage. (2) CTX has potent mutagenic effect, giving remarkable rise to MNF of PCE. 75 mGy γ-ray pre-irradiation has not obvious protection against genetic toxicity of high-dose CTX chemotherapy. (authors)

  1. Storm damage in the Black Forest caused by the winter storm "Lothar" – Part 1: Airborne damage assessment

    Directory of Open Access Journals (Sweden)

    J. Schmoeckel

    2008-08-01

    Full Text Available An airborne survey of the Black Forest as affected by the winter storm "Lothar" in 1999 is performed by means of a color line scanner (CLS with a CCD sensor, whose data in a visible and a near-infrared channel provide the Normalized Difference Vegetation Index (NDVI as a measure of the damage in previously intact forest areas. The camera data, height data from a digital evelation model (DEM, land use information, and soil data are georeferenced and processed in a geographic information system (GIS to derive relationship of the damage pattern to the characteristics of the local orography and soil types. The data cover an area of 4900 km2, 2767 km2 of which were forested. The 363 detected storm damage areas with a minimum detection size of 1.5 ha amount to 0.8% of the total forest area. Visual inspections at certain sites prove that none of the larger damage areas are missed, but areas smaller than 1.5 ha cause the total damage area to be up to twice our result, i.e. ≈1.6% of the forest area. More than 50% of the detected damaged areas are smaller than 5 ha and most of them have a size ranging from 1.5 to 3.5 ha. Forests on slopes with an inclination angle between 10 and 15 degrees show the highest fraction of damaged forest, doubling those on plains and below 5 degrees inclination angle. Forests on northwestern slopes are more affected than those on southwestern and western slopes, which faced the wind during highest wind speed occurrence. In contrast to other studies, this paper shows, that in steep areas, lee slopes are more damaged than the luv slopes. As expected, wet to moist soils represent an unstable location for the trees. But also medium-dry to dry locations that were considered to be relatively stable exhibited a highly damaged forest fraction. This can be attributed to mostly saturated soil from previous rain.

  2. Manual on the Fatigue of Structures. II. Causes and Prevention of Damage. 7. Mechanical Surface Damage,

    Science.gov (United States)

    1981-06-01

    AO-A103 «29 ADVISORY 6R0UP FOR AEROSPACE RESEARCH AND DEVELOPMENT—ETC F/O 20/11 MANUAL ON THE FATIfUE OF STRUCTURES. IX. CAUSES AND PREVENTION —ETC... stresses . In the case of 99.999% pure aluminium Vyas and Preece240 investigated the changes in the surface finish of the metal under the electron...during the erosion process. In the case of annealed nickel and of electrolytically polished test specimens cavitation- stressed in distilled water at 25°C

  3. Chronic Broca's Aphasia Is Caused by Damage to Broca's and Wernicke's Areas.

    Science.gov (United States)

    Fridriksson, Julius; Fillmore, Paul; Guo, Dazhou; Rorden, Chris

    2015-12-01

    Despite being perhaps the most studied form of aphasia, the critical lesion location for Broca's aphasia has long been debated, and in chronic patients, cortical damage often extends far beyond Broca's area. In a group of 70 patients, we examined brain damage associated with Broca's aphasia using voxel-wise lesion-symptom mapping (VLSM). We found that damage to the posterior portion of Broca's area, the pars opercularis, is associated with Broca's aphasia. However, several individuals with other aphasic patterns had considerable damage to pars opercularis, suggesting that involvement of this region is not sufficient to cause Broca's aphasia. When examining only individuals with pars opercularis damage, we found that patients with Broca's aphasia had greater damage in the left superior temporal gyrus (STG; roughly Wernicke's area) than those with other aphasia types. Using discriminant function analysis and logistic regression, based on proportional damage to the pars opercularis and Wernicke's area, to predict whether individuals had Broca's or another types of aphasia, over 95% were classified correctly. Our findings suggest that persons with Broca's aphasia have damage to both Broca's and Wernicke's areas, a conclusion that is incongruent with classical neuropsychology, which has rarely considered the effects of damage to both areas. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  4. Calculating externalities from damages in occupational health and safety

    Energy Technology Data Exchange (ETDEWEB)

    Burtraw, D; Shefftz, J

    1994-07-01

    This paper surveys the theoretical basis for the possibility that coal miner occupational health and safety damages are not adequately internalized into the production cost of mining coal and thereby impose an external cost on society.

  5. Calculating externalities from damages in occupational health and safety

    International Nuclear Information System (INIS)

    Burtraw, D.; Shefftz, J.

    1994-01-01

    This paper surveys the theoretical basis for the possibility that coal miner occupational health and safety damages are not adequately internalized into the production cost of mining coal and thereby impose an external cost on society

  6. Dysfunctional health service conflict: causes and accelerants.

    Science.gov (United States)

    Nelson, H Wayne

    2012-01-01

    This article examines the causes and accelerants of dysfunctional health service conflict and how it emerges from the health system's core hierarchical structures, specialized roles, participant psychodynamics, culture, and values. This article sets out to answer whether health care conflict is more widespread and intense than in other settings and if it is, why? To this end, health care power, gender, and educational status gaps are examined with an eye to how they undermine open communication, teamwork, and collaborative forms of conflict and spark a range of dysfunctions, including a pervasive culture of fear; the deny-and-defend lawsuit response; widespread patterns of hierarchical, generational, and lateral bullying; overly avoidant conflict styles among non-elite groups; and a range of other behaviors that lead to numerous human resource problems, including burnout, higher staff turnover, increased errors, poor employee citizenship behavior, patient dissatisfaction, increased patient complaints, and lawsuits. Bad patient outcomes include decreased compliance and increased morbidity and mortality. Health care managers must understand the root causes of these problems to treat them at the source and implement solutions that avoid negative conflict spirals that undermine organizational morale and efficiency.

  7. Methimazole-induced hypothyroidism causes cellular damage in the spleen, heart, liver, lung and kidney.

    Science.gov (United States)

    Cano-Europa, Edgar; Blas-Valdivia, Vanessa; Franco-Colin, Margarita; Gallardo-Casas, Carlos Angel; Ortiz-Butrón, Rocio

    2011-01-01

    It is known that a hypothyroidism-induced hypometabolic state protects against oxidative damage caused by toxins. However, some workers demonstrated that antithyroid drug-induced hypothyroidism can cause cellular damage. Our objective was to determine if methimazole (an antithyroid drug) or hypothyroidism causes cellular damage in the liver, kidney, lung, spleen and heart. Twenty-five male Wistar rats were divided into 5 groups: euthyroid, false thyroidectomy, thyroidectomy-induced hypothyroidism, methimazole-induced hypothyroidism (60 mg/kg), and treatment with methimazole (60 mg/kg) and a T₄ injection (20 μg/kg/d sc). At the end of the treatments (4 weeks for the pharmacological groups and 8 weeks for the surgical groups), the animals were anesthetized with sodium pentobarbital and they were transcardially perfused with 10% formaldehyde. The spleen, heart, liver, lung and kidney were removed and were processed for embedding in paraffin wax. Coronal sections were stained with hematoxylin-eosin. At the end of treatment, animals with both the methimazole- and thyroidectomy-induced hypothyroidism had a significant reduction of serum concentration of thyroid hormones. Only methimazole-induced hypothyroidism causes cellular damage in the kidney, lung, liver, heart, kidney and spleen. In addition, animals treated with methimazole and T₄ showed cellular damage in the lung, spleen and renal medulla with lesser damage in the liver, renal cortex and heart. The thyroidectomy only altered the lung structure. The alterations were prevented by T₄ completely in the heart and partially in the kidney cortex. These results indicate that tissue damage found in hypothyroidism is caused by methimazole. Copyright © 2009 Elsevier GmbH. All rights reserved.

  8. An animal experimental model for evaluating endothelial damage caused by various angiographic contrast media

    International Nuclear Information System (INIS)

    Gottlob, R.

    1981-01-01

    The endothelial damage caused by X-ray contrast media is tested on en face preparations of the rat aorta after silver staining. Hypertonic contrast media cause dehydration of the vessels so that solutions of silver nitrate penetrate into the media during the phase of rehydration whereby medial transverse lines are stained. These artifacts can be avoided by 3 minute rehydration of the vessels by Ringer solution prior to silver staining. In addition it is recommended to add highly diluted silver nitrate to the fixing media in order to intensify the pattern of the endothelial silver lines. Modern contrast media may cause very little endothelial damage, however, significant differences can be detected when in addition to the evaluation of larger foci damages of single endothelial cells ( brown cells with sparing of the nuclei and pseudonuclei ) are evaluated as well. No significant differences were found between the endothelial toxicity of meglumin diatrizoate and meglumin iothalamate. (orig.) [de

  9. Liability for damage caused by shortage and failure to use necessary medical devices

    Directory of Open Access Journals (Sweden)

    Cvetković Mihajlo

    2014-01-01

    Full Text Available In order to provide for successful, safe and high quality medical services, health care institutions need to be equipped with adequate medical devices. For this reason, every medical institution is legally obliged to have relevant medical devices. In case a patient has been deprived of some medical service for the lack of necessary medical devices (which the institution has been obliged to provide, the medical institution is responsible for the damage and harm sustained by the patient. The responsibility implies non-contractual liability (in tort law or pre-contractual liability (in contract law. In both cases, the liability is based on the presumed culpability. In order to be excluded from liability, the medical institution has to prove that the patient has been deprived of medical service (or that the institution has refused to enter into a medical service provider agreement on justifiable grounds, i.e. due to the lack of necessary medical devices. On the other hand, in case the medial institutions fail to provide needed care or violate their obligation to use medical devices when necessary, it is regarded as medical negligence (professional error. In most cases, it implies the liability of medical institutions for damage, injury or harm caused to the patient by medical services provided without applying a relevant medical device, whose use has been medically indicated. The liability is even more substantial in cases where the medical device has been available but the medical institutions has not applied it in medial treatment (even though its use has been medically indicated; such conduct is qualified as gross negligence.

  10. Hippocampal damage causes retrograde but not anterograde memory loss for context fear discrimination in rats.

    Science.gov (United States)

    Lee, Justin Q; Sutherland, Robert J; McDonald, Robert J

    2017-09-01

    There is a substantial body of evidence that the hippocampus (HPC) plays and essential role in context discrimination in rodents. Studies reporting anterograde amnesia (AA) used repeated, alternating, distributed conditioning and extinction sessions to measure context fear discrimination. In addition, there is uncertainty about the extent of damage to the HPC. Here, we induced conditioned fear prior to discrimination tests and rats sustained extensive, quantified pre- or post-training HPC damage. Unlike previous work, we found that extensive HPC damage spares context discrimination, we observed no AA. There must be a non-HPC system that can acquire long-term memories that support context fear discrimination. Post-training HPC damage caused retrograde amnesia (RA) for context discrimination, even when rats are fear conditioned for multiple sessions. We discuss the implications of these findings for understanding the role of HPC in long-term memory. © 2017 Wiley Periodicals, Inc.

  11. A Study on health damage due to air pollution

    Energy Technology Data Exchange (ETDEWEB)

    Han, Hwa Jin; Oh, So Young [Korea Environment Institute, Seoul (Korea)

    1998-12-01

    According to the domestic and foreign change in given conditions of air preservation policy, the air preservation policy in Korea should be implemented scientifically and reasonably. A gradual turnover to receptor-oriented reflecting human health and ecological effect is needed to establish and promote the air preservation policy systemically and in a long-term basis. Based on the quantified health damage of a people, air preservation policy in Korea should develop as a management policy to develop and implement an optimum management mechanism to minimized health damage of receptor. 19 refs., 2 figs., 25 tabs.

  12. Threats to repair injury caused by judicial errors and criminal damage

    Directory of Open Access Journals (Sweden)

    Muntean Vasilisa

    2017-12-01

    Full Text Available The grounds for the occurrence of punitive damages are related to the illicit actions of the persons with responsibilities in the courts and the criminal prosecution bodies. In order to provide protection against such unfair situations, there are a number of legal guarantees. The legislator has highlighted both the specific circle of reasons (illegal detention, unlawful criminal prosecution, unlawful sentencing, etc. necessary to ensure that the damage caused to the person can be repaired, as well as the circle of conditions for the right to reparation (the acquittal, the order for termination of the criminal proceedings or for the prosecution, etc.. The reparation of the damage caused by judicial and criminal prosecution errors arises at the time when the act whereby the person was convicted or illegally arrested, ie at the time when the rehabilitation act became irrevocable, was found to be illegal.

  13. Cell damage caused by vaginal Candida albicans isolates from women with different symptomatologies.

    Science.gov (United States)

    Faria, Daniella Renata; Sakita, Karina Mayumi; Akimoto-Gunther, Luciene Setsuko; Kioshima, Érika Seki; Svidzinski, Terezinha Inez Estivalet; Bonfim-Mendonça, Patrícia de Souza

    2017-08-01

    The present study aimed to characterize cell damage caused by vaginal Candida albicans isolates from women with different symptomatologies. It was evaluated 12 clinical isolates of C. albicans from vaginal samples: 4 from asymptomatic women (AS), 4 from women with a single episode of vulvovaginal candidiasis (VVC) and 4 from women with recurrent vulvovaginal candidiasis (RVVC). We evaluated the ability of C. albicans to adhere to human cervical cancer cells (SiHa), the yeast-SiHa cell interactions and cell damage. All of the clinical isolates presented a high adhesion capacity on SiHa cells. However, clinical isolates from symptomatic women (VVC and RVVC) had higher filamentation after contact (24 h) with SiHa cells and a greater capacity to cause cell damage (>80 %). Clinical isolates from symptomatic women had greater potential to invade SiHa cells, suggesting that they are more pathogenic than AS isolates.

  14. Compensation for damage caused by abuse of procedural rights in civil litigation

    Directory of Open Access Journals (Sweden)

    Rakočević Milka V.

    2017-01-01

    Full Text Available The paper discusses the issue of compensation for damage caused by the abuse of procedural rights as a measure within the oppressive apparatus for sanctioning the abuse of process in civil proceedings, which issue is, unlike others related to the idea of prohibition of abuse of rights within the system of civil procedure, the least treated in the procedural doctrine. The author deals with procedural aspects of certain essential issues that are important in the context of the matter concerned, highlighting the nature of the claim for damages caused by the abuse of process, the manner this right is realized (whether in the pending litigation or by initiating a separate civil procedure, the procedural form of the claim for compensation of damages, etc.

  15. Evaluation of environmental damage due to atmospheric pollution caused by power economy

    International Nuclear Information System (INIS)

    Burneikis, J.; Shtreimikiene, D.

    1996-01-01

    Methods to evaluate the environmental damage due to atmospheric pollution caused by power economy are presented. The products of burning fossil fuel (CO 2 , SO 2 , NO x and ashes) make the bulk of the pollutants that are being discharged into the atmosphere. To evaluate the damage caused by these pollutants an empirical method is suggested. The direct and analytical methods are used as a basis in collecting data for the empirical evaluation. All the three methods are described and empirical formulas suggested for calculating environmental damage due to burning fossil fuel in thermal power stations. The authors prove the necessity to change the present system of environmental taxes in Lithuania, which are purely symbolic. (author). 8 refs., 9 tabs

  16. Bruxism is unlikely to cause damage to the periodontium: findings from a systematic literature assessment

    NARCIS (Netherlands)

    Manfredini, D.; Ahlberg, J.; Mura, R.; Lobbezoo, F.

    2015-01-01

    Background: This paper systematically reviews the MEDLINE and SCOPUS literature to answer the following question: Is there any evidence that bruxism may cause periodontal damage per se? Methods: Clinical studies on humans, assessing the potential relationship between bruxism and periodontal lesions

  17. Foliar Nutritional Quality Explains Patchy Browsing Damage Caused by an Invasive Mammal.

    Directory of Open Access Journals (Sweden)

    Hannah R Windley

    Full Text Available Introduced herbivores frequently inflict significant, yet patchy damage on native ecosystems through selective browsing. However, there are few instances where the underlying cause of this patchy damage has been revealed. We aimed to determine if the nutritional quality of foliage could predict the browsing preferences of an invasive mammalian herbivore, the common brushtail possum (Trichosurus vulpecula, in a temperate forest in New Zealand. We quantified the spatial and temporal variation in four key aspects of the foliar chemistry (total nitrogen, available nitrogen, in vitro dry matter digestibility and tannin effect of 275 trees representing five native tree species. Simultaneously, we assessed the severity of browsing damage caused by possums on those trees in order to relate selective browsing to foliar nutritional quality. We found significant spatial and temporal variation in nutritional quality among individuals of each tree species examined, as well as among tree species. There was a positive relationship between the available nitrogen concentration of foliage (a measure of in vitro digestible protein and the severity of damage caused by browsing by possums. This study highlights the importance of nutritional quality, specifically, the foliar available nitrogen concentration of individual trees, in predicting the impact of an invasive mammal. Revealing the underlying cause of patchy browsing by an invasive mammal provides new insights for conservation of native forests and targeted control of invasive herbivores in forest ecosystems.

  18. Consumption of Coprinus comatus polysaccharide extract causes recovery of alcoholic liver damage in rats

    NARCIS (Netherlands)

    Ozalp, F.O.; Canbek, M.; Yamac, M.; Kanbak, G.; Griensven, van L.J.L.D.; Uyanoglu, M.; Senturk, H.; Karlkava, K.; Oglakci, A.

    2014-01-01

    Excess use of alcohol is known to be associated with liver diseases such as fatty liver, alcoholic hepatitis, and cirrhosis. Various practices may be applied to prevent or treat the damage caused by chronic alcoholism. Coprinus comatus (O.F. Müll.) Pers. (Agaricaceae) is a macrofungus that has been

  19. Protective Effect of Cleistocalyx nervosum var. paniala Fruit Extract against Oxidative Renal Damage Caused by Cadmium

    Directory of Open Access Journals (Sweden)

    Warut Poontawee

    2016-01-01

    Full Text Available Cadmium nephrotoxicity is a serious environmental health problem as it will eventually end up with end stage renal disease. The pathobiochemical mechanism of this toxic heavy metal is related to oxidative stress. This study investigated whether Cleistocalyx nervosum var. paniala fruit extract (CNFE could protect the kidney against oxidative injury caused by cadmium. Initial analysis of the extract revealed antioxidant abilities and high levels of polyphenols, particularly catechin. Its potential renal benefits was further explored in rats treated with vehicle, CNFE, cadmium (2 mg/kg, and cadmium plus CNFE (0.5, 1, 2 g/kg for four weeks. Oxidative renal injury was developed after cadmium exposure as evidenced by blood urea nitrogen and creatinine retention, glomerular filtration reduction, renal structural damage, together with increased nitric oxide and malondialdehyde, but decreased antioxidant thiols, superoxide dismutase, and catalase in renal tissues. Cadmium-induced nephrotoxicity was diminished in rats supplemented with CNFE, particularly at the doses of 1 and 2 g/kg. It is concluded that CNFE is able to protect against the progression of cadmium nephrotoxicity, mostly via its antioxidant power. The results also point towards a promising role for this naturally-occurring antioxidant to combat other human disorders elicited by disruption of redox homeostasis.

  20. Static-transmission-error vibratory-excitation contributions from plastically deformed gear teeth caused by tooth bending-fatigue damage

    Science.gov (United States)

    Mark, W. D.; Reagor, C. P.

    2007-02-01

    To assess gear health and detect gear-tooth damage, the vibratory response from meshing gear-pair excitations is commonly monitored by accelerometers. In an earlier paper, strong evidence was presented suggesting that, in the case of tooth bending-fatigue damage, the principal source of detectable damage is whole-tooth plastic deformation; i.e. yielding, rather than changes in tooth stiffness caused by tooth-root cracks. Such plastic deformations are geometric deviation contributions to the "static-transmission-error" (STE) vibratory excitation caused by meshing gear pairs. The STE contributions caused by two likely occurring forms of such plastic deformations on a single tooth are derived, and displayed in the time domain as a function of involute "roll distance." Example calculations are provided for transverse contact ratios of Qt=1.4 and 1.8, for spur gears and for helical-gear axial contact ratios ranging from Qa=1.2 to Qa=3.6. Low-pass- and band-pass-filtered versions of these same STE contributions also are computed and displayed in the time domain. Several calculations, consisting of superposition of the computed STE tooth-meshing fundamental harmonic contribution and the band-pass STE contribution caused by a plastically deformed tooth, exhibit the amplitude and frequency or phase modulation character commonly observed in accelerometer-response waveforms caused by damaged teeth. General formulas are provided that enable computation of these STE vibratory-excitation contributions for any form of plastic deformation on any number of teeth for spur and helical gears with any contact ratios.

  1. Analyses of the Secondary Particle Radiation and the DNA Damage it Causes to Human Keratinocytes

    Energy Technology Data Exchange (ETDEWEB)

    Lebel E. A.; Tafrov S.; Rusek, A.; Sivertz, M. B.; Yip, K.; Thompson, K. H.

    2011-11-01

    High-energy protons, and high mass and energy ions, along with the secondary particles they produce, are the main contributors to the radiation hazard during space explorations. Skin, particularly the epidermis, consisting mainly of keratinocytes with potential for proliferation and malignant transformation, absorbs the majority of the radiation dose. Therefore, we used normal human keratinocytes to investigate and quantify the DNA damage caused by secondary radiation. Its manifestation depends on the presence of retinol in the serum-free media, and is regulated by phosphatidylinositol 3-kinases. We simulated the generation of secondary radiation after the impact of protons and iron ions on an aluminum shield. We also measured the intensity and the type of the resulting secondary particles at two sample locations; our findings agreed well with our predictions. We showed that secondary particles inflict DNA damage to different extents, depending on the type of primary radiation. Low-energy protons produce fewer secondary particles and cause less DNA damage than do high-energy protons. However, both generate fewer secondary particles and inflict less DNA damage than do high mass and energy ions. The majority of cells repaired the initial damage, as denoted by the presence of 53BPI foci, within the first 24 hours after exposure, but some cells maintained the 53BP1 foci longer.

  2. Management of wildlife causing damage at Argonne National Laboratory-East, DuPage County, Illinois

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    The DOE, after an independent review, has adopted an Environmental Assessment (EA) prepared by the US Department of Agriculture (USDA) which evaluates use of an Integrated Wildlife Damage Management approach at Argonne National Laboratory-East (ANL-E) in DuPage County, Illinois (April 1995). In 1994, the USDA issued a programmatic Environmental Impact Statement (EIS) that covers nationwide animal damage control activities. The EA for Management of Wildlife Causing Damage at ANL-E tiers off this programmatic EIS. The USDA wrote the EA as a result of DOE`s request to USDA to prepare and implement a comprehensive Wildlife Management Damage Plan; the USDA has authority for animal damage control under the Animal Damage Control Act of 1931, as amended, and the Rural Development, Agriculture and Related Agencies Appropriations Act of 1988. DOE has determined, based on the analysis in the EA, that the proposed action does not constitute a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, the preparation of an EIS is not required. This report contains the Environmental Assessment, as well as the Finding of No Significant Impact (FONSI).

  3. Structural Health Management of Damaged Aircraft Structures Using the Digital Twin Concept

    Science.gov (United States)

    Seshadri, Banavara R.; Krishnamurthy, Thiagarajan

    2017-01-01

    The development of multidisciplinary integrated Structural Health Management (SHM) tools will enable accurate detection, and prognosis of damaged aircraft under normal and adverse conditions during flight. As part of the digital twin concept, methodologies are developed by using integrated multiphysics models, sensor information and input data from an in-service vehicle to mirror and predict the life of its corresponding physical twin. SHM tools are necessary for both damage diagnostics and prognostics for continued safe operation of damaged aircraft structures. The adverse conditions include loss of control caused by environmental factors, actuator and sensor faults or failures, and structural damage conditions. A major concern in these structures is the growth of undetected damage/cracks due to fatigue and low velocity foreign object impact that can reach a critical size during flight, resulting in loss of control of the aircraft. To avoid unstable, catastrophic propagation of damage during a flight, load levels must be maintained that are below a reduced load-carrying capacity for continued safe operation of an aircraft. Hence, a capability is needed for accurate real-time predictions of damage size and safe load carrying capacity for structures with complex damage configurations. In the present work, a procedure is developed that uses guided wave responses to interrogate damage. As the guided wave interacts with damage, the signal attenuates in some directions and reflects in others. This results in a difference in signal magnitude as well as phase shifts between signal responses for damaged and undamaged structures. Accurate estimation of damage size, location, and orientation is made by evaluating the cumulative signal responses at various pre-selected sensor locations using a genetic algorithm (GA) based optimization procedure. The damage size, location, and orientation is obtained by minimizing the difference between the reference responses and the

  4. Evaluation of roadside greenbelt trees damage caused by strangler plants in Bogor

    Science.gov (United States)

    Danniswari, Dibyanti; Nasrullah, Nizar

    2017-10-01

    Certain plants are called stranglers (hemiepiphyte) because they grow on host trees and slowly choking the host, which often results in the host’s death. The existence of strangler plants on roadside greenbelt trees is quite common in Bogor, but they may cause tree’s failure and threaten users’ safety. To prevent such hazard, evaluation of roadside greenbelt trees damage caused by strangler plants is important. This study was directed to analyse the vegetation of strangler plants in Bogor, to assess the damage caused by stranglers, and to compose strangled trees maintenance recommendations. This study was conducted in March to May 2014 by doing survey at five major roads in Bogor, which were Jalan Ahmad Yani, Jalan Sudirman, Jalan Pemuda, Jalan Semeru, and Jalan Juanda. The results showed that strangler species found in Bogor are Ficus benjamina, Ficus glauca, Ficus elastica, and Schefflera actinophylla. The most common species in Bogor is F. benjamina. Host trees that tend to be preferred by strangler plants are trees with large trunk, many branches, and medium to high height. The maintenance for every strangled tree is different according to the damage level, mild to severe damage could be treated by strangler root cutting to tree logging, respectively.

  5. Meta-analysis of attitudes toward damage-causing mammalian wildlife.

    Science.gov (United States)

    Kansky, Ruth; Kidd, Martin; Knight, Andrew T

    2014-08-01

    Many populations of threatened mammals persist outside formally protected areas, and their survival depends on the willingness of communities to coexist with them. An understanding of the attitudes, and specifically the tolerance, of individuals and communities and the factors that determine these is therefore fundamental to designing strategies to alleviate human-wildlife conflict. We conducted a meta-analysis to identify factors that affected attitudes toward 4 groups of terrestrial mammals. Elephants (65%) elicited the most positive attitudes, followed by primates (55%), ungulates (53%), and carnivores (44%). Urban residents presented the most positive attitudes (80%), followed by commercial farmers (51%) and communal farmers (26%). A tolerance to damage index showed that human tolerance of ungulates and primates was proportional to the probability of experiencing damage while elephants elicited tolerance levels higher than anticipated and carnivores elicited tolerance levels lower than anticipated. Contrary to conventional wisdom, experiencing damage was not always the dominant factor determining attitudes. Communal farmers had a lower probability of being positive toward carnivores irrespective of probability of experiencing damage, while commercial farmers and urban residents were more likely to be positive toward carnivores irrespective of damage. Urban residents were more likely to be positive toward ungulates, elephants, and primates when probability of damage was low, but not when it was high. Commercial and communal farmers had a higher probability of being positive toward ungulates, primates, and elephants irrespective of probability of experiencing damage. Taxonomic bias may therefore be important. Identifying the distinct factors explaining these attitudes and the specific contexts in which they operate, inclusive of the species causing damage, will be essential for prioritizing conservation investments. © 2014 The Authors. Conservation Biology

  6. Magnesium-oxide boards cause moisture damage inside facades in new Danish buildings

    DEFF Research Database (Denmark)

    Hansen, Kurt Kielsgaard; Bunch-Nielsen, Tommy; Grelk, Bent

    2016-01-01

    building elements seemed to suffer from some sort of disease, which manifested itself by damages such as significant moisture, boards leaking salty water (‘tears’), corrosion of fittings and anchors and mould growth. The damages were caused by the fact that MgO-boards absorb moisture from outside air...... in periods with high outdoor humidity (90-100% RH) and form water drops on the surfaces. The drops contain a high amount of soluble chloride ions and appear on the surfaces of the boards and may often run down the boards and to adjacent structures. Metal fixtures for the MgO-and siding boards may corrode...

  7. ILLEGAL ACTS - CONDITION OF LIABILITY FOR DAMAGES CAUSED IN EXERCISING LEGAL LABOR RELATIONS

    Directory of Open Access Journals (Sweden)

    Ştefania-Alina Dumitrache

    2014-11-01

    Full Text Available According to article 253 and 254 of Labor Code, both employers and employees are responsible under the rules and principles of contractual liability for damages to the other party of legal labor relationship and we emphasize that this is not purely civil liability, but a variety of it, determined by the specific peculiarities of legal labor relations. Thus, we highlight that labor law provisions which refer to liability for damages complement, unquestionably, with the common law relating to civil liability. The paper analyzes the objective basis of legal accountability, namely the illicit act causing damages committed in fulfilling labor duties or in connection tot hem, therewith the method detailed and comparative documentation of legislation in the field and relevant doctrine.

  8. Protective effects of Curcuma longa against neurobehavioral and neurochemical damage caused by cerium chloride in mice.

    Science.gov (United States)

    Kadri, Yamina; Nciri, Riadh; Brahmi, Noura; Saidi, Saber; Harrath, Abdel Halim; Alwasel, Saleh; Aldahmash, Waleed; El Feki, Abdelfatteh; Allagui, Mohamed Salah

    2018-05-07

    Cerium chloride (CeCl 3 ) is considered an environmental pollutant and a potent neurotoxic agent. Medicinal plants have many bioactive compounds that provide protection against damage caused by such pollutants. Curcuma longa is a bioactive compound-rich plant with very important antioxidant properties. To study the preventive and healing effects of Curcuma longa on cerium-damaged mouse brains, we intraperitoneally injected cerium chloride (CeCl 3 , 20 mg/kg BW) along with Curcuma longa extract, administrated by gavage (100 mg/kg BW), into mice for 60 days. We then examined mouse behavior, brain tissue damage, and brain oxidative stress parameters. Our results revealed a significant modification in the behavior of the CeCl 3 -treated mice. In addition, CeCl 3 induced a significant increment in lipid peroxidation, carbonyl protein (PCO), and advanced oxidation protein product levels, as well as a significant reduction in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. Acetylcholinesterase (AChE) activity remarkably increased in the brain of CeCl 3 -treated mice. Histopathological observations confirmed these results. Curcuma longa attenuated CeCl 3 -induced oxidative stress and increased the activities of antioxidant enzymes. It also decreased AChE activity in the CeCl 3 -damaged mouse brain that was confirmed by histopathology. In conclusion, this study suggests that Curcuma longa has a neuroprotective effect against CeCl 3 -induced damage in the brain.

  9. Salt stress causes cell wall damage in yeast cells lacking mitochondrial DNA.

    Science.gov (United States)

    Gao, Qiuqiang; Liou, Liang-Chun; Ren, Qun; Bao, Xiaoming; Zhang, Zhaojie

    2014-03-03

    The yeast cell wall plays an important role in maintaining cell morphology, cell integrity and response to environmental stresses. Here, we report that salt stress causes cell wall damage in yeast cells lacking mitochondrial DNA (ρ 0 ). Upon salt treatment, the cell wall is thickened, broken and becomes more sensitive to the cell wall-perturbing agent sodium dodecyl sulfate (SDS). Also, SCW11 mRNA levels are elevated in ρ 0 cells. Deletion of SCW11 significantly decreases the sensitivity of ρ 0 cells to SDS after salt treatment, while overexpression of SCW11 results in higher sensitivity. In addition, salt stress in ρ 0 cells induces high levels of reactive oxygen species (ROS), which further damages the cell wall, causing cells to become more sensitive towards the cell wall-perturbing agent.

  10. Health and Safety of Hyderabad Industries’ Labor. Causes and Awareness

    Directory of Open Access Journals (Sweden)

    A. R. Khoso

    2017-12-01

    Full Text Available Labor’s health and safety (H&S is a matter of concern for all industries. Occurrence of accidents in industries is becoming a common issue. Both white collar and blue-collar workers are not shielded from materials that damage their health. This study identifies the critical factors affecting labor’s H&S in Hyderabad, Pakistan industries. The awareness of labor regarding prevention and consequences that affect workers’ H&S is also a matter of interest of this research. The severity of factors was determined through questionnaire survey from experts, H&S supervisors and managerial staff of industries. For the descriptive analysis the software SPPS 24.0 was used. This research also includes interviews form industry laborers about awareness regarding H&S critical factors. The results show that, Improper PPE use, operating machines that are poorly maintained, long term exposure to high intensity noise, working extended and irregular hours and lack of knowledge of working instruments are the critical causes of accidents. Also 60.9%, 73.9%, 69.6%, 78.3% and 89% of workers are not aware about these causes and their consequences. Thus, this research is a road map for industrial employers, law makers, local, provisional and federal Government of Pakistan in order to help minimizing the workplace accidents and the providing of safe and secure working environment for laborers.

  11. Damage to lens fiber cells causes TRPV4-dependent Src family kinase activation in the epithelium.

    Science.gov (United States)

    Shahidullah, M; Mandal, A; Delamere, N A

    2015-11-01

    The bulk of the lens consists of tightly packed fiber cells. Because mature lens fibers lack mitochondria and other organelles, lens homeostasis relies on a monolayer of epithelial cells at the anterior surface. The detection of various signaling pathways in lens epithelial cells suggests they respond to stimuli that influence lens function. Focusing on Src Family Kinases (SFKs) and Transient Receptor Potential Vanilloid 4 (TRPV4), we tested whether the epithelium can sense and respond to an event that occurs in fiber mass. The pig lens was subjected to localized freeze-thaw (FT) damage to fibers at posterior pole then the lens was incubated for 1-10 min in Krebs solution at 37 °C. Transient SFK activation in the epithelium was detectable at 1 min. Using a western blot approach, the ion channel TRPV4 was detected in the epithelium but was sparse or absent in fiber cells. Even though TRPV4 expression appears low at the actual site of FT damage to the fibers, SFK activation in the epithelium was suppressed in lenses subjected to FT damage then incubated with the TRPV4 antagonist HC067047 (10 μM). Na,K-ATPase activity was examined because previous studies report changes of Na,K-ATPase activity associated with SFK activation. Na,K-ATPase activity doubled in the epithelium removed from FT-damaged lenses and the response was prevented by HC067047 or the SFK inhibitor PP2 (10 μM). Similar changes were observed in response to fiber damage caused by injection of 5 μl hyperosmotic NaCl or mannitol solution beneath the surface of the posterior pole. The findings point to a TRPV4-dependent mechanism that enables the epithelial cells to detect remote damage in the fiber mass and respond within minutes by activating SFK and increasing Na,K-ATPase activity. Because TRPV4 channels are mechanosensitive, we speculate they may be stimulated by swelling of the lens structure caused by damage to the fibers. Increased Na,K-ATPase activity gives the lens greater capacity to

  12. Annealing damage caused by implantation of group IB elements into silicon

    International Nuclear Information System (INIS)

    Johansen, A.; Svenningsen, B.; Chadderton, L.T.; Whitton, J.L.

    1976-01-01

    Transmission electron microscopy (TEM) and the Rutherford backscattering method (RBS) have been used in an investigation of the annealing of radiation damage produced in silicon by 80 keV Cu + , Ag + and Au + ions up to doses of 10 15 ions/cm 2 . Whilst the damage caused by Cu + and Ag + implantation, measured by RBS, persists following annealing sequences up to temperatures of 800 0 C, Au + -implanted samples show recovery. Furthermore, RBS indicates quite clearly that, in the case of gold, atomic diffusion to the silicon surface takes place. TEM and electron diffraction both indicate that in all three implants the anomalous 'damage' remaining in RBS spectra is due to an amorphous-polycrystalline transition. In the case of Au + implants, however, there is less inhibition of the process of recovery, quite apart from the thermal history of the sample. The importance of using another technique, especially TEM, in conjunction with RBS investigations of radiation damage in the solid state is emphasized. (author)

  13. Tumor induced hepatic myeloid derived suppressor cells can cause moderate liver damage.

    Directory of Open Access Journals (Sweden)

    Tobias Eggert

    Full Text Available Subcutaneous tumors induce the accumulation of myeloid derived suppressor cells (MDSC not only in blood and spleens, but also in livers of these animals. Unexpectedly, we observed a moderate increase in serum transaminases in mice with EL4 subcutaneous tumors, which prompted us to study the relationship of hepatic MDSC accumulation and liver injury. MDSC were the predominant immune cell population expanding in livers of all subcutaneous tumor models investigated (RIL175, B16, EL4, CT26 and BNL, while liver injury was only observed in EL4 and B16 tumor-bearing mice. Elimination of hepatic MDSC in EL4 tumor-bearing mice using low dose 5-fluorouracil (5-FU treatment reversed transaminase elevation and adoptive transfer of hepatic MDSC from B16 tumor-bearing mice caused transaminase elevation indicating a direct MDSC mediated effect. Surprisingly, hepatic MDSC from B16 tumor-bearing mice partially lost their damage-inducing potency when transferred into mice bearing non damage-inducing RIL175 tumors. Furthermore, MDSC expansion and MDSC-mediated liver injury further increased with growing tumor burden and was associated with different cytokines including GM-CSF, VEGF, interleukin-6, CCL2 and KC, depending on the tumor model used. In contrast to previous findings, which have implicated MDSC only in protection from T cell-mediated hepatitis, we show that tumor-induced hepatic MDSC themselves can cause moderate liver damage.

  14. Tumor induced hepatic myeloid derived suppressor cells can cause moderate liver damage.

    Science.gov (United States)

    Eggert, Tobias; Medina-Echeverz, José; Kapanadze, Tamar; Kruhlak, Michael J; Korangy, Firouzeh; Greten, Tim F

    2014-01-01

    Subcutaneous tumors induce the accumulation of myeloid derived suppressor cells (MDSC) not only in blood and spleens, but also in livers of these animals. Unexpectedly, we observed a moderate increase in serum transaminases in mice with EL4 subcutaneous tumors, which prompted us to study the relationship of hepatic MDSC accumulation and liver injury. MDSC were the predominant immune cell population expanding in livers of all subcutaneous tumor models investigated (RIL175, B16, EL4, CT26 and BNL), while liver injury was only observed in EL4 and B16 tumor-bearing mice. Elimination of hepatic MDSC in EL4 tumor-bearing mice using low dose 5-fluorouracil (5-FU) treatment reversed transaminase elevation and adoptive transfer of hepatic MDSC from B16 tumor-bearing mice caused transaminase elevation indicating a direct MDSC mediated effect. Surprisingly, hepatic MDSC from B16 tumor-bearing mice partially lost their damage-inducing potency when transferred into mice bearing non damage-inducing RIL175 tumors. Furthermore, MDSC expansion and MDSC-mediated liver injury further increased with growing tumor burden and was associated with different cytokines including GM-CSF, VEGF, interleukin-6, CCL2 and KC, depending on the tumor model used. In contrast to previous findings, which have implicated MDSC only in protection from T cell-mediated hepatitis, we show that tumor-induced hepatic MDSC themselves can cause moderate liver damage.

  15. The application of SEM in analyzing the damage to the petroleum reservoirs caused by drilling fluids

    International Nuclear Information System (INIS)

    Abdul Razak Ismail

    1996-01-01

    An experimental study has been conducted to analyze the damage to the potential oil and gas reservoirs due to the invasion of drilling fluid during drilling operation. Two types of rock samples representing low and high permeability were used to stimulate the petroleum reservoirs. Sea water based drilling fluids were used in this study. Detail observations to the rock samples were analyzed using scanning electron microscope (SEM). The results of both permeability restoration and SEM observation showed that severe permeability impairments were obtained for high permeability rock. These results indicate that the relative size of the barite particles and the pore size distribution and characteristics of the formation play an important role in determining the damage caused by the drilling fluids

  16. Reduction of aesthetical properties of organic coatings caused by mechanical damage

    International Nuclear Information System (INIS)

    Rossi, S.; Deflorian, F.; Scrinzi, E.

    2009-01-01

    Organic coatings are the most commonly used system for protection from corrosion. In many applications, the protective properties against corrosion are associated with several other properties, including resistance to abrasion and good aesthetic appearance. This is particularly important for the automotive and transport industry, building trade, domestic products, packaging. To evaluate the abrasion resistance of organic coatings the Taber Abraser test is frequently used. The aim of this work is to evaluate the reduction of aesthetical properties, caused by abrasion by Taber test, using different abrasive pastes. The level of damage was evaluated through gloss measurements; 20 deg. was the most sensitive angle to gloss changes, with this geometry different samples could be compared. The correlation between the changes of gloss and the damage was investigated using optical microscopy and environmental scanning electron microscopy. With increase of grain dimensions, the paste became more abrasive with negative effect on the aesthetical aspect of the organic coating

  17. Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility

    Science.gov (United States)

    Bai, Yuhong; Zhang, Yi; Zhang, Jingping; Mu, Qingxin; Zhang, Weidong; Butch, Elizabeth R.; Snyder, Scott E.; Yan, Bing

    2010-09-01

    Soluble carbon nanotubes show promise as materials for in vivo delivery and imaging applications. Several reports have described the in vivo toxicity of carbon nanotubes, but their effects on male reproduction have not been examined. Here, we show that repeated intravenous injections of water-soluble multiwalled carbon nanotubes into male mice can cause reversible testis damage without affecting fertility. Nanotubes accumulated in the testes, generated oxidative stress and decreased the thickness of the seminiferous epithelium in the testis at day 15, but the damage was repaired at 60 and 90 days. The quantity, quality and integrity of the sperm and the levels of three major sex hormones were not significantly affected throughout the 90-day period. The fertility of treated male mice was unaffected; the pregnancy rate and delivery success of female mice that mated with the treated male mice did not differ from those that mated with untreated male mice.

  18. Phototherapy causes DNA damage in peripheral mononuclear leukocytes in term infants.

    Science.gov (United States)

    Aycicek, Ali; Kocyigit, Abdurrahim; Erel, Ozcan; Senturk, Hakan

    2008-01-01

    Our aim was to determine whether endogenous mononuclear leukocyte DNA strand is a target of phototherapy. The study included 65 term infants aged between 3-10 days that had been exposed to intensive (n = 23) or conventional (n = 23) phototherapy for at least 48 hours due to neonatal jaundice, and a control group (n = 19). DNA damage was assayed by single-cell alkaline gel electrophoresis (comet assay). Plasma total antioxidant capacity and total oxidant status levels were also measured, and correlation between DNA damage and oxidative stress was investigated. Mean values of DNA damage scores in both the intensive and conventional phototherapy groups were significantly higher than those in the control group (p Total oxidant status levels in both the intensive and conventional phototherapy groups were significantly higher than those in the control group (p = 0.005). Mean (standard deviation) values were 18.1 (4.2), 16.9 (4.4), 13.5 (4.2) micromol H2O2 equivalent/L, respectively. Similarly, oxidative stress index levels in both the intensive and conventional phototherapy groups were significantly higher than those in the control group (p = 0.041). Plasma total antioxidant capacity and total bilirubin levels did not differ between the groups (p > 0.05). There were no significant correlations between DNA damage scores and bilirubin, total oxidant status and oxidative stress levels in either phototherapy group (p > 0.05). Both conventional phototherapy and intensive phototherapy cause endogenous mononuclear leukocyte DNA damage in jaundiced term infants.

  19. Does job loss cause ill health?

    NARCIS (Netherlands)

    Salm, M.

    2009-01-01

    This study estimates the effect of job loss on health for near elderly employees based on longitudinal data from the Health and Retirement Study. Previous studies find a strong negative correlation between unemployment and health. To control for possible reverse causality, this study focuses on

  20. NOx emissions from large point sources: variability in ozone production, resulting health damages and economic costs

    International Nuclear Information System (INIS)

    Mauzerall, D.L.; Namsoug Kim

    2005-01-01

    We present a proof-of-concept analysis of the measurement of the health damage of ozone (O 3 ) produced from nitrogen oxides (NO x =NO+NO 2 ) emitted by individual large point sources in the eastern United States. We use a regional atmospheric model of the eastern United States, the Comprehensive Air quality Model with Extensions (CAMx), to quantify the variable impact that a fixed quantity of NO x emitted from individual sources can have on the downwind concentration of surface O 3 , depending on temperature and local biogenic hydrocarbon emissions. We also examine the dependence of resulting O 3 -related health damages on the size of the exposed population. The investigation is relevant to the increasingly widely used 'cap and trade' approach to NO x regulation, which presumes that shifts of emission over time and space, holding the total fixed over the course of the summer O 3 season, will have minimal effect on the environmental outcome. By contrast, we show that a shift of a unit of NO x emissions from one place or time to another could result in large changes in resulting health effects due to O 3 formation and exposure. We indicate how the type of modeling carried out here might be used to attach externality-correcting prices to emissions. Charging emitters fees that are commensurate with the damage caused by their NO x emissions would create an incentive for emitters to reduce emissions at times and in locations where they cause the largest damage. (author)

  1. Characterization of non-dimer DNA lesions and cellular damages caused by ultraviolet light

    International Nuclear Information System (INIS)

    Nakao, Kumi

    1989-01-01

    To understand the mechanisms of carcinogenicity and cytotoxicity induced by ultraviolet (UV) light, non-dimer DNA damages produced by near UV light (wave-length: 290∼320 nm) were examined by alkaline elution using Chinese hamster V-79 cells. UV exposure produced a dose-dependent induction of DNA single strand breaks and DNA-protein crosslinks. However, neither of these DNA lesions were repaired within a 24 hr incubation of the cells following UV exposure. Rather the number of these lesions increased. Also, UV exposure inhibited DNA and RNA synthesis. In addition, UV induced both cytotoxicity and chromosomal aberration. Electron spin resornance (ESR) studies showed that the exposure of cells to UV light resulted in the appearance of an ESR signal at -120degC. The roles of glutathione, vitamin E and vitamin B 2 , which were celluar antioxidant, on the induction of cytotoxicity by UV exposure were also examined. Pretreatment with vitamin E reduced the cytotoxicty caused by UV, whereas neither preteatment with vitamin B 2 nor the alteration of cellular gluthaione content affected the cytotoxicity. These results suggest that non-dimer DNA damages, such as DNA single strand breaks and DNA-protein crosslinks play an important role in inducing UV-carcinogenicity and UV-cytotoxicity, and that the mechanisms of these damages may be associated with the generation of free radicals. (author)

  2. Damage Mechanism in Counter Pairs Caused by Bionic Non-smoothed Surface

    Directory of Open Access Journals (Sweden)

    ZHANG Zhan-hui

    2016-08-01

    Full Text Available Four biomimetic non-smoothed surface specimens with different shapes were prepared by laser processing. Tests were conducted on MMU-5G wear and abrasion test machine to study the influencing rule of non-smoothed surfaces on counter pairs. The results show that the mass loss of the friction pair matching with the non-smoothed units is much greater than the ones matching with the smooth specimens. The pairs matching with different non-smoothed units suffer differently. The non-smoothed surface protruding zone exerts micro cutting on counter pairs. The striation causes the greatest mass loss of the pairs than the other non-smoothed units, which almost doubles the damage of the grid ones suffering the least. The difference in pairs damage is attributed to the different mechanism of undertaking the load in the process of wear. The damage can be alleviated effectively by changing the shapes of the units without increasing or decreasing the area ratio of the non-smoothed units.

  3. Oxidative Damage Caused by Common Foodborne Pathogenic Bacteria in Egg Yolk

    Directory of Open Access Journals (Sweden)

    Reyhaneh Afshordi

    2016-02-01

    Full Text Available Background: Bacteria in foodstuff are the most important agent of foodborne disease. Aside from their infectious effects, obligate aerobes have a respiratory metabolism with oxygen as the terminal electron acceptor. Therefore, they can produce reactive oxygen species and free radicals in contaminated food. Malondialdehyde (MDA is a product of lipid peroxidation used as an indicator of oxidative stress. Objectives: This study aimed to evaluate the oxidative damage produced by two common food pathogenic bacteria in foodstuff. Materials and Methods: The egg yolks were incubated with different dilutions (105,106, and 107 of Staphylococcus aureus and Salmonella enteritidis at 37°C for 20 hours. The level of MDA in egg yolk was measured by fast and simple enzymatic or colorimetric methods, such as the thiobarbituric acid reactive species method. Results: The high group (107 had a higher MDA level of 1.97 ± 0.11 (μg MDA/g in S. aureus and 1.65 ± 0.27 (mg MDA/L in S. enteritidis than the control (0.90 ± 0.13 mg MDA/L. Conclusions: We concluded that common food pathogenic bacteria can induce oxidative damage in foodstuff aside from other common problems. Heating or sterilization methods cannot protect foodstuff from the damage caused by the presence of pathogenic bacteria.

  4. Aerial pesticide application causes DNA damage in pilots from Sinaloa, Mexico.

    Science.gov (United States)

    Martínez-Valenzuela, C; Waliszewski, S M; Amador-Muñoz, O; Meza, E; Calderón-Segura, M E; Zenteno, E; Huichapan-Martínez, J; Caba, M; Félix-Gastélum, R; Longoria-Espinoza, R

    2017-01-01

    The use of pesticides in agricultural production originates residues in the environment where they are applied. Pesticide aerial application is a frequent source of exposure to pesticides by persons dedicated to agricultural practices and those living in neighboring communities of sprayed fields. The aim of the study was to assess the genotoxic effects of pesticides in workers occupationally exposed to these chemicals during their aerial application to agricultural fields of Sinaloa, Mexico. The study involved 30 pilots of airplanes used to apply pesticides via aerial application and 30 unexposed controls. Damage was evaluated through the micronucleus assay and by other nuclear abnormalities in epithelial cells of oral mucosa. The highest frequency ratios (FR) equal to 269.5 corresponded to binucleated cells followed by 54.2, corresponding to cells with pyknotic nuclei, 45.2 of cells with chromatin condensation, 3.7 of cells with broken-egg, 3.6 of cells with micronucleus, and 2.0 of karyolytic cells. Age, worked time, smoking, and alcohol consumption did not have significant influence on nuclear abnormalities in the pilots studied. Pesticide exposure was the main factor for nuclear abnormality results and DNA damage. Marked genotoxic damage was developed even in younger pilots with 2 years of short working period, caused by their daily occupational exposure to pesticides.

  5. Causes and Consequences of Sensory Hair Cell Damage and Recovery in Fishes.

    Science.gov (United States)

    Smith, Michael E; Monroe, J David

    2016-01-01

    Sensory hair cells are the mechanotransductive receptors that detect gravity, sound, and vibration in all vertebrates. Damage to these sensitive receptors often results in deficits in vestibular function and hearing. There are currently two main reasons for studying the process of hair cell loss in fishes. First, fishes, like other non-mammalian vertebrates, have the ability to regenerate hair cells that have been damaged or lost via exposure to ototoxic chemicals or acoustic overstimulation. Thus, they are used as a biomedical model to understand the process of hair cell death and regeneration and find therapeutics that treat or prevent human hearing loss. Secondly, scientists and governmental natural resource managers are concerned about the potential effects of intense anthropogenic sounds on aquatic organisms, including fishes. Dr. Arthur N. Popper and his students, postdocs and research associates have performed pioneering experiments in both of these lines of fish hearing research. This review will discuss the current knowledge regarding the causes and consequences of both lateral line and inner ear hair cell damage in teleost fishes.

  6. Moderate Thermal Stress Causes Active and Immediate Expulsion of Photosynthetically Damaged Zooxanthellae (Symbiodinium from Corals.

    Directory of Open Access Journals (Sweden)

    Lisa Fujise

    Full Text Available The foundation of coral reef biology is the symbiosis between corals and zooxanthellae (dinoflagellate genus Symbiodinium. Recently, coral bleaching, which often results in mass mortality of corals and the collapse of coral reef ecosystems, has become an important issue around the world as coral reefs decrease in number year after year. To understand the mechanisms underlying coral bleaching, we maintained two species of scleractinian corals (Acroporidae in aquaria under non-thermal stress (27°C and moderate thermal stress conditions (30°C, and we compared the numbers and conditions of the expelled Symbiodinium from these corals. Under non-thermal stress conditions corals actively expel a degraded form of Symbiodinium, which are thought to be digested by their host coral. This response was also observed at 30°C. However, while the expulsion rates of Symbiodinium cells remained constant, the proportion of degraded cells significantly increased at 30°C. This result indicates that corals more actively digest and expel damaged Symbiodinium under thermal stress conditions, likely as a mechanism for coping with environmental change. However, the increase in digested Symbiodinium expulsion under thermal stress may not fully keep up with accumulation of the damaged cells. There are more photosynthetically damaged Symbiodinium upon prolonged exposure to thermal stress, and corals release them without digestion to prevent their accumulation. This response may be an adaptive strategy to moderate stress to ensure survival, but the accumulation of damaged Symbiodinium, which causes subsequent coral deterioration, may occur when the response cannot cope with the magnitude or duration of environmental stress, and this might be a possible mechanism underlying coral bleaching during prolonged moderate thermal stress.

  7. Moderate Thermal Stress Causes Active and Immediate Expulsion of Photosynthetically Damaged Zooxanthellae (Symbiodinium) from Corals.

    Science.gov (United States)

    Fujise, Lisa; Yamashita, Hiroshi; Suzuki, Go; Sasaki, Kengo; Liao, Lawrence M; Koike, Kazuhiko

    2014-01-01

    The foundation of coral reef biology is the symbiosis between corals and zooxanthellae (dinoflagellate genus Symbiodinium). Recently, coral bleaching, which often results in mass mortality of corals and the collapse of coral reef ecosystems, has become an important issue around the world as coral reefs decrease in number year after year. To understand the mechanisms underlying coral bleaching, we maintained two species of scleractinian corals (Acroporidae) in aquaria under non-thermal stress (27°C) and moderate thermal stress conditions (30°C), and we compared the numbers and conditions of the expelled Symbiodinium from these corals. Under non-thermal stress conditions corals actively expel a degraded form of Symbiodinium, which are thought to be digested by their host coral. This response was also observed at 30°C. However, while the expulsion rates of Symbiodinium cells remained constant, the proportion of degraded cells significantly increased at 30°C. This result indicates that corals more actively digest and expel damaged Symbiodinium under thermal stress conditions, likely as a mechanism for coping with environmental change. However, the increase in digested Symbiodinium expulsion under thermal stress may not fully keep up with accumulation of the damaged cells. There are more photosynthetically damaged Symbiodinium upon prolonged exposure to thermal stress, and corals release them without digestion to prevent their accumulation. This response may be an adaptive strategy to moderate stress to ensure survival, but the accumulation of damaged Symbiodinium, which causes subsequent coral deterioration, may occur when the response cannot cope with the magnitude or duration of environmental stress, and this might be a possible mechanism underlying coral bleaching during prolonged moderate thermal stress.

  8. [Neuroprotective effect of naloxone in brain damage caused by repeated febrile seizure].

    Science.gov (United States)

    Shan, Ying; Qin, Jiong; Chang, Xing-zhi; Yang, Zhi-xian

    2004-04-01

    The brain damage caused by repeated febrile seizure (FS) during developing age is harmful to the intellectual development of children. So how to decrease the related damage is a very important issue. The main purpose of the present study was to find out whether the non-specific opiate antagonist naloxone at low dose has the neuroprotective effect on seizure-induced brain damage. Warm water induced rat FS model was developed in this study. Forty-seven rats were randomly divided into two groups: normal control group (n = 10) and hyperthermic seizure groups (n = 37). The latter was further divided into FS control group (n = 13) and naloxone-treated group (n = 24). The dose of naloxone is different in two naloxone-treated groups (12/each group), in one group the dose was 1 mg/kg, in the other one 2 mg/kg. Seven febrile seizures were induced in each rat of hyperthermic seizure groups with the interval of 2 days. The rats were weighed and injected intraperitoneally with naloxone once the FS occurred in naloxone-treated group, while the rats of the other groups were injected with 0.9% sodium chloride. Latency, duration and grade of FS in different groups were observed and compared. HE-staining and the electron microscopy (EM) were used to detect the morphologic and ultrastructural changes of hippocampal neurons. In naloxone-treated group, the rats' FS duration and FS grade (5.02 +/- 0.63, 2.63 +/- 0.72) were significantly lower (t = 5.508, P seizure, it could lighten the brain damage resulted from repeated FS to some extent.

  9. How Networks of Informal Trails Cause Landscape Level Damage to Vegetation.

    Science.gov (United States)

    Barros, Agustina; Marina Pickering, Catherine

    2017-07-01

    When visitors are not constrained to remain on formal trails, informal trail networks can develop and damage plant communities in protected areas. These networks can form in areas with low growing vegetation, where formal trails are limited, where there is limited regulation and where vegetation is slow to recover once disturbed. To demonstrate the extent of impacts from unregulated recreational use, we assessed damage to alpine vegetation by hikers and pack animals in the highest protected area in the southern Hemisphere: Aconcagua Park, in the Andes. Within the 237 ha area surveyed in the Horcones Valley, over 19 km of trails were found, nearly all of which (94%) were informal. This network of trails resulted in the direct loss of 11.5 ha of vegetation and extensive fragmentation of alpine meadows (21 fragments) and steppe vegetation (68 fragments). When levels of disturbance off these trails were quantified using rapid visual assessments, 81% of 102 randomly located plots showed evidence of disturbance, with the severity of disturbance greatest close to trails. As a result, vegetation in 90% of the Valley has been damaged by visitor use, nearly all of it from unregulated use. These results highlight the extent to which informal trails and trampling off-trail can cause landscape damage to areas of high conservation value, and hence the importance of better regulation of visitor use. The methodology used for off-trail impact assessment can be easily applied or adapted for other popular protected areas where trampling off-trail is also an issue.

  10. Prediction of the extent of formation damage caused by water injection

    Energy Technology Data Exchange (ETDEWEB)

    Al-Homadhi, Emad S. [King Saud Univ., Riyadh (Saudi Arabia). Petroleum Engineering Dept.

    2013-06-15

    As a general practice water is injected along the O/W contact to maintain reservoir pressure during production. Down hole analysis of the injected water shows that, even after surface treatment, it still can contain a considerable amount of solid particles. These particles can bridge formation pores and cause a considerable reduction in the injectivity. To ensure good injectivity over a longer term, the concentration and size of these solids should not exceed certain limits. In this article core flood tests were carried out to simulate high rate injectors. The injected brine contained solid particles in different concentrations and sizes. Particle concentration was between 5 and 20 ppm and the particle mean size was between 2 and 9 {mu}m. The results were presented as damaging ratio versus pore volume injected. Contrarily to previous studies instead of using experimental results in calibrating or evaluating certain theoretical models, the results in this study were directly fitted to produce equations which can predict the extent of damage caused by injected water by knowing the mean size and concentration of the solid particles contained in that water. (orig.)

  11. THE ROLE OF CYTOKINE NETWORK IN HEPATOCELLULAR DAMAGE CAUSED BY СHRONIC HEPATITIS C

    Directory of Open Access Journals (Sweden)

    L. Ph. Skljar

    2006-01-01

    Full Text Available Abstract. Hepatitis C virus (HCV is the leading cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Liver damage in chronic viral hepatitis C is caused by both direct cytopathic viral effects, and indirect immune-mediated mechanisms. The cytokines locally produced in the liver, as well as those circulating in the blood circulation, play an important role in the control of viral replication and sufficiently contribute to hepatocellular damage. The goal of present study was to investigate the contents of some cytokines in blood serum and their local levels, being in interrelation with indices of necrotic inflammatory changes in the liver tissue. Correlations established between systemic and local contents of studied cytokines, and morphological indices indicate that, among immunological tests checked, the contents of IL-4, IL-10, IL-12p70, and TNFα in blood serum and supernatants of liver biopsies were of the greatest significance for determining the stage of fibrosis. Quantitative assays of abovementioned cytokines in blood serum represent, therefore, an alternative approach in order to perform noninvasive screening of liver fibrosis.

  12. Influence of damage caused by Kr ions and neutrons on electrical properties of silicon detectors

    CERN Document Server

    Croitoru, N; Rancoita, P G; Rattaggi, M; Seidman, A

    1999-01-01

    In this paper, new measurements of physical properties of high-resistivity silicon, used in high-energy detectors, are presented. The obtained data contribute to the understanding of the causes which damage the 2electronic characteristics of the detection systems under irradiation of neutrons and ionized particles (Kr). The Hall effect coefficient (R sub H) and resistivity (rho) measurements as a function of temperature (T), for non-irradiated and irradiated by neutrons and Kr ions, were performed. The measurements of the Hall coefficient and resistivity of non-irradiated samples and irradiated at neutron fluences (PHI=9.9x10 sup 1 sup 0 n/cm sup 2 (neutrons) and PHI>=7.5x10 sup 8 Kr/cm sup 3 (ions), cannot be explained, considering the usual theoretical relations. The results, obtained in these experiments, have shown a change of mechanism of conduction due to the damaged regions, where localized levels are created, which are the main cause of the deviation of the electrical characteristics of the detectors ...

  13. Bruxism is unlikely to cause damage to the periodontium: findings from a systematic literature assessment.

    Science.gov (United States)

    Manfredini, Daniele; Ahlberg, Jari; Mura, Rossano; Lobbezoo, Frank

    2015-04-01

    This paper systematically reviews the MEDLINE and SCOPUS literature to answer the following question: Is there any evidence that bruxism may cause periodontal damage per se? Clinical studies on humans, assessing the potential relationship between bruxism and periodontal lesions (i.e., decreased attachment level, bone loss, tooth mobility/migration, altered periodontal perception) were eligible. Methodologic shortcomings were identified by the adoption of the Critical Appraisal Skills Program quality assessment, mainly concerning the internal validity of findings according to an unspecific bruxism diagnosis. The six included articles covered a high variability of topics, without multiple papers on the same argument. Findings showed that the only effect of bruxism on periodontal structures was an increase in periodontal sensation, whereas a relationship with periodontal lesions was absent. Based on the analysis of Hill criteria, the validity of causation conclusions was limited, mainly owing to the absence of a longitudinal evaluation of the temporal relationship and dose-response effects between bruxism and periodontal lesions. Despite the scarce quantity and quality of the literature that prevents sound conclusions on the causal link between bruxism and the periodontal problems assessed in this review, it seems reasonable to suggest that bruxism cannot cause periodontal damage per se. It is also important to emphasize, however, that because of methodologic problems, particularly regarding sleep bruxism assessment, more high-quality studies (e.g., randomized controlled trials) are needed to further clarify this issue.

  14. Health impact and damage cost assessment of pesticides in Europe.

    Science.gov (United States)

    Fantke, Peter; Friedrich, Rainer; Jolliet, Olivier

    2012-11-15

    Health impacts from pesticide use are of continuous concern in the European population, requiring a constant evaluation of European pesticide policy. However, health impacts have never been quantified accounting for specific crops contributing differently to overall human exposure as well as accounting for individual substances showing distinct environmental behavior and toxicity. We quantify health impacts and related damage costs from exposure to 133 pesticides applied in 24 European countries in 2003 adding up to almost 50% of the total pesticide mass applied in that year. Only 13 substances applied to 3 crop classes (grapes/vines, fruit trees, vegetables) contribute to 90% of the overall health impacts of about 2000 disability-adjusted life years in Europe per year corresponding to annual damage costs of 78 million Euro. Considering uncertainties along the full impact pathway mainly attributable to non-cancer dose-response relationships and residues in treated crops, we obtain an average burden of lifetime lost per person of 2.6 hours (95% confidence interval between 22 seconds and 45.3 days) or costs per person over lifetime of 12 Euro (95% confidence interval between 0.03 Euro and 5142 Euro), respectively. 33 of the 133 assessed substances accounting for 20% of health impacts in 2003 are now banned from the European market according to current legislation. The main limitation in assessing human health impacts from pesticides is related to the lack of systematic application data for all used substances. Since health impacts can be substantially influenced by the choice of pesticides, the need for more information about substance application becomes evident. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. The inadequate liability and compensation regime for damage caused by nuclear activities

    International Nuclear Information System (INIS)

    Dyke, Jon M. Van

    2010-09-01

    The specific obligation to provide restitution and compensation when nuclear activities cause injuries has been recognized repeatedly and is now certainly part of customary international law. But problems remain regarding how to measure damages, how to implement the duty to repair the injuries, and what specific obligations exist to protect neighboring states from transboundary pollution. Although some treaties exist governing liability for harm resulting from nuclear accidents, they are not adequate to protect victims and have not been widely ratified. The failure to require nuclear operators to prepare for damage that may result from accidents constitutes a subsidy to the nuclear industry and makes it difficult to compare the real costs of nuclear energy with the costs of other energy sources. This survey of settled norms and unresolved issues demonstrates that further work is needed to develop a comprehensive and authoritative regime to govern harm from nuclear activities. Although it is clear that both the operators of nuclear facilities and the states that have jurisdiction over them would be responsible to provide restitution and compensation for such harm under a strict liability regime, the types of injuries that must be compensated and the range of damages that must be covered remain subjects of controversy. Although the underlying customary international law principles (the no-harm principle and the polluter-pays principle) are clear, the actual treaties that have been drafted are inadequate and they have not been widely ratified. Victims of damage from nuclear activities would have difficulty finding a neutral tribunal in which to bring their claims and would face procedural obstacles including caps on liabilities and inappropriately short statutes of limitations as well as difficulties regarding proof of damages. The failure to develop a proper regime that would ensure full restitution and compensation for harm resulting from nuclear facilities

  16. Causes and avoidance of container damages by means of biocorrosion; Ursachen und Vermeidung von Behaelterschaeden durch Biokorrosion

    Energy Technology Data Exchange (ETDEWEB)

    Kuever, Jan [Amtliche Materialpruefungsanstalt Bremen (MPA), Bremen (Germany)

    2011-07-01

    The contribution under consideration deals with the causes and prevention of vessel damages due to corrosion by microorganisms (MIC, microbially induced corrosion) in the presence and absence of oxygen. In particular, the microbially induced corrosion by sulfate-reducing bacteria and the formation of sulfuric acid by microorganisms are described. Consequential damage caused by microorganisms are inactivation of filters and catalysts, degradation products from the fermentation process and deposits in the pipe system.

  17. DNA damage and genetic methylation changes caused by Cd in Arabidopsis thaliana seedlings.

    Science.gov (United States)

    Li, Zhaoling; Liu, Zhihong; Chen, Ruijuan; Li, Xiaojun; Tai, Peidong; Gong, Zongqiang; Jia, Chunyun; Liu, Wan

    2015-09-01

    Amplified fragment length polymorphism (AFLP) and methylation-sensitive amplification polymorphism (MASP) techniques are sensitive to deoxyribonucleic acid (DNA) damage and genetic methylation, respectively. Using these 2 techniques, Arabidopsis thaliana cultured with 0 mg/L (control), 0.5 mg/L, 1.5 mg/L, and 5.0 mg/L Cd(2+) for 16 d was used to analyze the DNA damage and methylation changes as a result of cadmium (Cd). The DNA was amplified by 14 AFLP primer pairs and 13 MSAP primer combinations. In the AFLP experiment, 62 polymorphic sites were found in the patterns of 11 primer combinations and a total of 1116 fragments were obtained in these patterns. There were no polymorphic bands in the remaining 3 pairs. The proportions of polymorphic sites in the 0.5-mg/L Cd(2+) and 5.0-mg/L Cd(2+) treatments were significantly different. Seven polymorphic fragments were then separated and successfully sequenced, yielding 6 nucleobase substitutions and 1 nucleobase deletion. Similarly, in the MSAP experiment, the MSAP% and number of demethylated-type bands were unchanged after Cd treatment, but the number of methylated-type bands was increased significantly in the 5.0-mg/L Cd(2+) treatment group, a finding that may be associated with the AFLP results. The polymorphic bands were also sequenced and the functions of their homologous genes were determined. The DNA damage and methylation changes may be the primary cause of certain pathology changes as a result of Cd uptake in plants. © 2015 SETAC.

  18. Local damage to Ultra High Performance Concrete structures caused by an impact of aircraft engine missiles

    International Nuclear Information System (INIS)

    Riedel, Werner; Noeldgen, Markus; Strassburger, Elmar; Thoma, Klaus; Fehling, Ekkehard

    2010-01-01

    Research highlights: → Experimental series on UHPC panels subjected to aircraft engine impact. → Improved ballistic limit of fiber reinforced UHPC in comparison to conventional R/C. → Detailed investigation of failure mechanisms of fiber reinforced UHPC panel. - Abstract: The impact of an aircraft engine missile causes high stresses, deformations and a severe local damage to conventional reinforced concrete. As a consequence the design of R/C protective structural elements results in components with rather large dimensions. Fiber reinforced Ultra High Performance Concrete (UHPC) is a concrete based material which combines ultra high strength, high packing density and an improved ductility with a significantly increased energy dissipation capacity due to the addition of fiber reinforcement. With those attributes the material is potentially suitable for improved protective structural elements with a reduced need for material resources. The presented paper reports on an experimental series of scaled aircraft engine impact tests with reinforced UHPC panels. The investigations are focused on the material behavior and the damage intensity in comparison to conventional concrete. The fundamental work of is taken as reference for the evaluation of the results. The impactor model of a Phantom F4 GE-J79 engine developed and validated by Sugano et al. is used as defined in the original work. In order to achieve best comparability, the experimental configuration and method are adapted for the UHPC experiments. With 'penetration', 'scabbing' and 'perforation' all relevant damage modes defined in are investigated so that a full set of results are provided for a representative UHPC structural configuration.

  19. Characterization of Aircraft Structural Damage Using Guided Wave Based Finite Element Analysis for In-Flight Structural Health Management

    Science.gov (United States)

    Seshadri, Banavara R.; Krishnamurthy, Thiagarajan; Ross, Richard W.

    2016-01-01

    The development of multidisciplinary Integrated Vehicle Health Management (IVHM) tools will enable accurate detection, diagnosis and prognosis of damage under normal and adverse conditions during flight. The adverse conditions include loss of control caused by environmental factors, actuator and sensor faults or failures, and structural damage conditions. A major concern is the growth of undetected damage/cracks due to fatigue and low velocity foreign object impact that can reach a critical size during flight, resulting in loss of control of the aircraft. To avoid unstable catastrophic propagation of damage during a flight, load levels must be maintained that are below the load-carrying capacity for damaged aircraft structures. Hence, a capability is needed for accurate real-time predictions of safe load carrying capacity for aircraft structures with complex damage configurations. In the present work, a procedure is developed that uses guided wave responses to interrogate damage. As the guided wave interacts with damage, the signal attenuates in some directions and reflects in others. This results in a difference in signal magnitude as well as phase shifts between signal responses for damaged and undamaged structures. Accurate estimation of damage size and location is made by evaluating the cumulative signal responses at various pre-selected sensor locations using a genetic algorithm (GA) based optimization procedure. The damage size and location is obtained by minimizing the difference between the reference responses and the responses obtained by wave propagation finite element analysis of different representative cracks, geometries and sizes.

  20. Agricultural and forest means to reduce damage caused by air pollution

    Energy Technology Data Exchange (ETDEWEB)

    Knabe, W

    1971-01-01

    Agriculture and forestry may try to reduce damage caused by air pollution by the following means: under heavy pollution sensitive crops can be replaced by more tolerant ones through changes in land use; at lower grades of air pollution the kind of land use may be maintained by planting relatively tolerant species and strains; breeding of plant material which is more tolerant than the present average is necessary to meet future requirements; certain damage may be decreased by soil amelioration, fertilization and watering of plants; the impact of certain air pollutants can be reduced by planting shelterbelts and by silvicultural means which affect the structure of a stand; and a strict control of insect pests and plant diseases is of special value in air polluted regions. Any special case has to be handled individually. It has to be asked whether one of the means mentioned above will be successful and in what area it should be applied. Several methods for the delineation of polluted regions are listed. Agricultural and forest means to adapt to a given situation of air pollution is gaining increasing importance because of the large areas with a medium high level of pollution, even if the general prospects of success are not regarded as very high.

  1. Fusarium infection causes genotoxic disorders and antioxidant-based damages in Orobanche spp.

    Science.gov (United States)

    Aybeke, Mehmet

    2017-08-01

    This study aims to evaluate the toxic effects of Fusarium oxysporum on root parasitic weed, Orobanche spp. Comparative genetic and gene expression studies were conducted on uninfected and fungus-infected orobanches. In genetic studies, isolated total DNA was amplified by RAPD PCR. Fragment properties were analysed by GTS test. According to the results, the fragment properties of control and Fusarium infected (experimental) groups varied widely; and it has been observed that Fusarium has genotoxic effects on the DNA of orobanches. In gene expression studies, the expression levels of genes encoding enzymes or proteins were associated with ROS damage and toxic effects, therefore, gene expressions of Mn-superoxide dismutase (SOD), Zn-superoxide dismutase (=SOD2, mitochondrial), glutamine synthetase (GS), heat shock protein gene (HSP70), BAX, Caspase-3 and BCL2 were significantly higher in the experimental group. In the light of obtained data, it was concluded that F. oxysporum (1) caused heavy ROS damage in Orobanche (2) induced significant irrevocable genotoxic effects on the DNA of Orobanche, (3) degraded protein metabolism and synthesis, and finally (4) triggered apoptosis. The results of this study can be a ground for further research on reducing the toxic effects of Fusarium on agricultural products, so that advancements in bio-herbicide technology may provide a sustainable agricultural production. Copyright © 2017 Elsevier GmbH. All rights reserved.

  2. Hardness and microstructure analysis of damaged gear caused by adhesive wear

    Science.gov (United States)

    Mahendra, Rizky Budi; Nugroho, Sri; Ismail, Rifky

    2018-03-01

    This study was a result from research on repairing project of damaged elevator gear box. The objective of this research is to analyze the failure part on elevator gearbox at flourmill factory. The equipment was damaged after one year installed and running on factory. Severe wear was occurred on high speed helical gear. These helical gear was one of main part of elevator gearbox in flour mill manufacture. Visually, plastic deformation didn't occurred and not visible on the failure helical gear shaft. Some test would be performed to check the chemical composition, microstructure and hardness of failure helical gear. The material of failure helical gear shaft was a medium carbon steel alloy. The microstructure was showed a martensitic phase formed on the surface to the center area of gear shaft. Otherwise, the depth of hardness layer slight formed on surface and lack depth of hardness layer was a main trigger of severe wear. It was not enough to resist wear due to friction caused by rolling and sliding on surface between high speed gear and low speed gear. Enhancement of hardness layer on surface and depth of hardness layer will make the component has more long life time. Furthermore, to perform next research is needed to analyze the reliability of enhanced hardness on layer and depth of hardness layer on helical gear shaft.

  3. Phakopsora euvitis Causes Unusual Damage to Leaves and Modifies Carbohydrate Metabolism in Grapevine

    Directory of Open Access Journals (Sweden)

    Antonio F. Nogueira Júnior

    2017-09-01

    Full Text Available Asian grapevine rust (Phakopsora euvitis is a serious disease, which causes severe leaf necrosis and early plant defoliation. These symptoms are unusual for a strict biotrophic pathogen. This work was performed to quantify the effects of P. euvitis on photosynthesis, carbohydrates, and biomass accumulation of grapevine. The reduction in photosynthetic efficiency of the green leaf tissue surrounding the lesions was quantified using the virtual lesion concept (β parameter. Gas exchange and responses of CO2 assimilation to increasing intercellular CO2 concentration were analyzed. Histopathological analyses and quantification of starch were also performed on diseased leaves. Biomass and carbohydrate accumulation were quantified in different organs of diseased and healthy plants. Rust reduced the photosynthetic rate, and β was estimated at 5.78, indicating a large virtual lesion. Mesophyll conductance, maximum rubisco carboxylation rate, and regeneration of ribulose-1,5-bisphosphate dependent on electron transport rate were reduced, causing diffusive and biochemical limitations to photosynthesis. Hypertrophy, chloroplast degeneration of mesophyll cells, and starch accumulation in cells close to lesions were observed. Root carbohydrate concentration was reduced, even at low rust severity. Asian grapevine rust dramatically reduced photosynthesis and altered the dynamics of production and accumulation of carbohydrates, unlike strict biotrophic pathogens. The reduction in carbohydrate reserves in roots would support polyetic damage on grapevine, caused by a polycyclic disease.

  4. Hypothyroidism Causes Endoplasmic Reticulum Stress in Adult Rat Hippocampus: A Mechanism Associated with Hippocampal Damage

    Directory of Open Access Journals (Sweden)

    Alejandra Paola Torres-Manzo

    2018-01-01

    Full Text Available Thyroid hormones (TH are essential for hippocampal neuronal viability in adulthood, and their deficiency causes hypothyroidism, which is related to oxidative stress events and neuronal damage. Also, it has been hypothesized that hypothyroidism causes a glucose deprivation in the neuron. This study is aimed at evaluating the temporal participation of the endoplasmic reticulum stress (ERE in hippocampal neurons of adult hypothyroid rats and its association with the oxidative stress events. Adult Wistar male rats were divided into euthyroid and hypothyroid groups. Thyroidectomy with parathyroid gland reimplementation caused hypothyroidism at three weeks postsurgery. Oxidative stress, redox environment, and antioxidant enzyme markers, as well as the expression of the ERE through the pathways of PERK, ATF6, and IRE1, were evaluated at the 3rd and 4th weeks postsurgery. We found a rise in ROS and nitrite production; also, catalase increased and glutathione peroxidase diminished their activities. These events promote an enhancement of the lipoperoxidation, as well as of γ-GT, myeloperoxidase, and caspase 3 activities. With respect to ERE, there were ATF6, IRE1, and GADD153 overexpressions with a reduction in mitochondrial activity and GSH2/GSSG ratio. We conclude that the endoplasmic reticulum stress might play a pivotal role in the activation of hypothyroidism-induced hippocampal cell death.

  5. Assessing the damage caused by the oil spill from the tanker Erika

    International Nuclear Information System (INIS)

    Delache, X.; Erhard-Cassegrain, A.

    2001-07-01

    In December 1999, France was faced with a large-scale marine and ecological disaster following the accident involving the oil tanker Erika which split in two before sinking off the coast of Brittany (western France). This disaster had significant impacts on the coastal environment, affecting 400 km of shoreline. Very different aspects need to be considered in order to assess the damage caused, for which suitable methodologies must be used. Expenditure incurred on emergency and remedial measures to prepare for the 2000 summer season can easily be identified. The main effect of the disaster was ecological: a wide variety of habitats and species, and in particular many protected areas were affected. In addition, economic activities were seriously disrupted, especially tourism, fishing and shellfish production. However, it is harder to assess the economic losses incurred since a large number of short-term and long-term factors were affected. (author)

  6. Irradiation damage to the gonads caused by radiotherapy of benign diseases. Pt. 2

    International Nuclear Information System (INIS)

    Hassenstein, E.; Nuesslin, F.

    1976-01-01

    The irradiation damage to the gonads caused by the radiotherapy of parotiditis and mastitis and of cheloids was determined partially under different irradiation methods. The measurements were carried out with LiF dosimeters in the Alderson phantom with a tube tension of 250 kV for the inflammatory diseases and 55 kV for the cheloids. The gonad dose measured at the surface was within the range of hundreths of permille for the parotiditis, for the mastitis it was between tenths of permille and 2 0 / 00 depending on the therapy method. The gonad dose of the cheloid irradiations showed a clear relation to the distance between radiation source and gonads. The importance of radiation protection is emphasized. (orig.) [de

  7. The changes of fingernail microcirculation in the patients with hand skin radiation damage caused by β rays

    International Nuclear Information System (INIS)

    Wang Guoquan; Qian Jianjun; Wang Zuofa

    2000-01-01

    Objective: To observe the microcirculation changes in the patients with hand skin radiation damage caused by β rays. Methods: The XOX-1A type microcirculation microscope was used in observation of the microcirculation changes of fingernail, in 22 patients with III-IV degree hand skin radiation damage caused by β rays. Results: A series of abnormal signs were observed in all these patients and it was found that the microcirculation abnormality of the fingernail were the most clinical significant sign. Conclusion: The fingernail microcirculation changes can be used as an indicator for prognosis in the hand skin radiation damage patients

  8. [Perspective on the nuclear power plant accident caused by the great east Japan earthquake and tsunami: health impairment risks due to pollution by radioactive materials from the damaged plant as recognized by experts and by the general population and role of the experts].

    Science.gov (United States)

    Sugita, Minoru; Miyakawa, Michiko

    2012-01-01

    Large amounts of radioactive materials were leaked into the environment from the Fukushima Daiichi Nuclear Power Plant (FDNPP) of the Tokyo Electric Power Company damaged by the 2011 Great East Japan Earthquake and accompanying tsunami. Increased health impairment risks due to the leaked radioactive materials are of concern over a long period of time and over a wide geographical area. From the results of epidemiologic studies conducted after the Chernobyl accident, the health risks are not anticipated to be very marked. The purpose of the present study is to examine (i) the elevated health risks as viewed by the general population, (ii) tolerance to the risks that the general population suffer from their viewpoint, and (iii) the overall picture as seen by researchers and experts in specialized areas of study after the accident. Information was obtained from articles in print and on the Internet and by interviewing a psychologist and tens of employees of several corporations. Epidemiologic studies conducted after the severe accident of the nuclear power plant in Chernobyl revealed an elevated risk of thyroid cancer in children due to (131)I while elevated risks due to radioactive materials other than (131)I were not detected. The amount of radioactive materials leaked into the environment from the FDNPP was less than that in Chernobyl. Therefore, it is possible to estimate that health impairment risks due to the leaked radioactive materials from the FDNPP are low. However, it is impossible to conclude a zero risk. It is likely that the general population does not fully understand the health impairment risks due to the leaked radioactive materials from the FDNPP. Although no increased incidences of diseases other than thyroid cancer of children were scientifically shown en masse from studies in Chernobyl, individual risks and results in the future caused by the severe accident of FDNPP cannot be denied. Much of the general population is apt to demand the security of

  9. Perspective on the nuclear power plant accident caused by the great east Japan earthquake and tsunami. Health impairment risks due to pollution by radioactive materials from the damaged plant as recognized by experts and by the general population and role of the experts

    International Nuclear Information System (INIS)

    Sugita, Minoru; Miyakawa, Michiko

    2012-01-01

    Large amounts of radioactive materials were leaked into the environment from the Fukushima Daiichi Nuclear Power Plant (FDNPP) of the Tokyo Electric Power Company damaged by the 2011 Great East Japan Earthquake and accompanying tsunami. Increased health impairment risks due to the leaked radioactive materials are of concern over a long period of time and over a wide geographical area. From the results of epidemiologic studies conducted after the Chernobyl accident, the health risks are not anticipated to be very marked. The purpose of the present study is to examine the elevated health risks as viewed by the general population, tolerance to the risks that the general population suffer from their viewpoint, and the overall picture as seen by researchers and experts in specialized areas of study after the accident. Information was obtained from articles in print and on the Internet and by interviewing a psychologist and tens of employees of several corporations. Epidemiologic studies conducted after the severe accident of the nuclear power plant in Chernobyl revealed an elevated risk of thyroid cancer in children due to 131 I while elevated risks due to radioactive materials other than 131 I were not detected. The amount of radioactive materials leaked into the environment from the FDNPP was less than that in Chernobyl. Therefore, it is possible to estimate that health impairment risks due to the leaked radioactive materials from the FDNPP are low. However, it is impossible to conclude a zero risk. It is likely that the general population does not fully understand the health impairment risks due to the leaked radioactive materials from the FDNPP. Although no increased incidences of diseases other than thyroid cancer of children were scientifically shown en masse from studies in Chernobyl, individual risks and results in the future caused by the severe accident of FDNPP cannot be denied. Much of the general population is apt to demand the security of a zero risk from

  10. Compensation for damage to workers health exposed to ionizing radiation in Argentina

    CERN Document Server

    Sobehart, L J

    2003-01-01

    The objective of this report is to analyze the possibility to establish a scheme to compensate damage to workers health exposed to ionizing radiation in Argentina for those cases in which it is possible to assume that the exposure to ionizing radiation is the cause of the cancer suffered by the worker. The proposed scheme is based on the recommendations set out in the 'International Conference on Occupational Radiation Protection: Protecting Workers against Exposure to Ionization Radiation, held in Geneva, Switzerland, August 26-30, 2002. To this end, the study analyzes the present state of scientific knowledge on cancer causation due to genotoxic factors, and the accepted form of the doses-response curve, for the human beings exposure to ionization radiation at low doses with low doses rates. Finally, the labor laws and regulations related to damage compensation; in particular the present Argentine Labor Law; the National Russian Federal Occupational Radiological Health Impairment and Workmen Compensation, t...

  11. The Carrier's Liability for Damage Caused by Delay in International Air Transport

    Science.gov (United States)

    Lee, Kang Bin

    2003-01-01

    Delay in the air transport occurs when passengers, baggage or cargo do not arrive at their destination at the time indicated in the contract of carriage. The causes of delay in the carriage of passengers are booking errors or double booking, delayed departure of aircraft, incorrect information regarding the time of departure, failure to land at the scheduled destination and changes in flight schedule or addition of extra landing stops. Delay in the carriage of baggage or cargo may have different causes: no reservation, lack of space, failure to load the baggage or cargo at the right place, or to deliver the covering documents at the right place. The Montreal Convention of 1999 Article 19 provides that 'The carrier is liable for damage occasioned by delay in the carriage by air of passengers, baggage or cargo. Nevertheless, the carder shall not be liable for damage occasioned by delay if it proves that it and its servants and agents took all measures that could reasonably be required to avoid the damage or that it was impossible for it or them to take such measures'. The Montreal Convention Article 22 provides liability limits of the carrier in case of delay for passengers and their baggage and for cargo. In the carriage of persons, the liability of the carrier for each passenger is limited to 4,150 SDR. In the carriage of baggage, the liability of the carrier is limited to 1,000 SDR for each passenger unless a special declaration as to the value of the baggage has been made. In the carriage of cargo, the liability of the carrier is limited to 17 SDR per kilogram unless a special declaration as to the value of the cargo has been made. The Montreal Convention Article 19 has shortcomings: it is silent on the duration of the liability for carriage,andit does not make any distinction between persons and good. It does not give any indication concerning the circumstances to be taken into account in cases of delay, and about the length of delay. In conclusion, it is

  12. Murine liver damage caused by exposure to nano-titanium dioxide

    International Nuclear Information System (INIS)

    Hong, Jie; Zhang, Yu-Qing

    2016-01-01

    Due to its unique physiochemical properties, nano-titanium dioxide (nano-TiO_2) is widely used in all aspects of people’s daily lives, bringing it into increasing contact with humans. Thus, this material’s security issues for humans have become a heavily researched subject. Nano-TiO_2 can enter the body through the mouth, skin, respiratory tract or in other ways, after which it enters the blood circulation and is deposited in the liver, changing biochemical indicators and causing liver inflammation. Meanwhile, the light sensitivity of these nanoparticles allows them to become media-generating reactive oxygen species (ROS), causing an imbalance between oxidation and anti-oxidation that leads to oxidative stress and liver damage. Nano-TiO_2 can be transported into cells via phagocytosis, where the nanoparticles bind to the mitochondrial membrane, resulting in the disintegration of the membrane and the electron transport chain within the mitochondria. Thus, more ROS are produced. Nano-TiO_2 can also enter the nucleus, where it can directly embed into or indirectly affect DNA, thereby causing DNA breakage or affecting gene expression. These effects include increased mRNA and protein expression levels of inflammation-related factors and decreased mRNA and protein expression levels of IκB and IL-2, resulting in inflammation. Long-term inflammation of the liver causes HSC cell activation, and extracellular matrix (ECM) deposition is promoted by multiple signalling pathways, resulting in liver fibrosis. In this paper, the latest progress on murine liver injury induced by environmental TiO_2 is systematically described. The toxicity of nano-TiO_2 also depends on size, exposure time, surface properties, dosage, administration route, and its surface modification. Therefore, its toxic effects in humans should be studied in greater depth. This paper also provides useful reference information regarding the safe use of nano-TiO_2 in the future. (topical review)

  13. Lysergic acid diethylamide causes photoreceptor cell damage through inducing inflammatory response and oxidative stress.

    Science.gov (United States)

    Hu, Qi-Di; Xu, Ling-Li; Gong, Yan; Wu, Guo-Hai; Wang, Yu-Wen; Wu, Shan-Jun; Zhang, Zhe; Mao, Wei; Zhou, Yu-Sheng; Li, Qin-Bo; Yuan, Jian-Shu

    2018-01-19

    Lysergic acid diethylamide (LSD), a classical hallucinogen, was used as a popular and notorious substance of abuse in various parts of the world. Its abuse could result in long-lasting abnormalities in retina and little is known about the exact mechanism. This study was to investigate the effect of LSD on macrophage activation state at non-toxic concentration and its resultant toxicity to photoreceptor cells. Results showed that cytotoxicity was caused by LSD on 661 W cells after co-culturing with RAW264.7 cells. Treatment with LSD-induced RAW264.7 cells to the M1 phenotype, releasing more pro-inflammatory cytokines, and increasing the M1-related gene expression. Moreover, after co-culturing with RAW264.7 cells, significant oxidative stress in 661 W cells treated with LSD was observed, by increasing the level of malondialdehyde (MDA) and reactive oxygen species (ROS), and decreasing the level of glutathione (GSH) and the activity of superoxide dismutase (SOD). Our study demonstrated that LSD caused photoreceptor cell damage by inducing inflammatory response and resultant oxidative stress, providing the scientific rationale for the toxicity of LSD to retina.

  14. Ex-core fuel damage event at paks causes, consequences and lessons learned

    International Nuclear Information System (INIS)

    Bajsz, J.; Gado, J.

    2004-01-01

    On April 10, 2003 Paks NPP experienced a loss of decay-heat removal to 30 irradiated fuel assemblies undergoing a cleaning process in a fuel service pit near the unit 2 spent fuel pool. Following chemical cleaning of high decay-heat fuel, a delay in removing the cleaning vessel's lid left the cleaning system in such a condition that did not provide adequate cooling to the fuel. After several hours of the fuel being under-cooled, a steam bubble developed in the vessel, essentially uncovering the fuel. When the lid of the vessel was removed, the sudden introduction of cool water thermally shocked the fuel causing significant structural damage and a release of fission product gases to the reactor building. The paper will discuss the causes of the event as well as the contributing factors to it. Detailed information will be given about the planning and preparation of the recovery actions. The in-depth analyses of the consequences and lessons learned complete the lecture. (author)

  15. ANALYSIS OF FACTORS CAUSING WATER DAMAGE TO LOESS DOUBLE-ARCHED TUNNEL BASED ON TFN-AHP

    Directory of Open Access Journals (Sweden)

    Mao Zheng-jun

    2017-04-01

    Full Text Available In order to analysis the factors causing water damage to loess double-arched tunnel, this paper conducts field investigation on water damage to tunnels on Lishi-Jundu Expressway in Shanxi, China, confirms its development characteristics, builds an index system (covering 36 evaluation indexes for construction condition, design stage, construction stage, and operation stage for the factors causing water damage to loess double-arched tunnel, applies TFN-AHP (triangular fuzzy number-analytic hierarchy process in calculating the weight of indexes at different levels, and obtains the final sequence of weight of the factors causing water seepage to loess double-arched tunnel. It is found out that water damage to loess double-arched tunnel always develops in construction joints, expansion joints, settlement joints, and lining joints of tunnel and even around them; there is dotted water seepage, linear water seepage, and planar water seepage according to the trace and scope of water damage to tunnel lining. The result shows that water damage to loess double-arched tunnel mainly refers to linear water seepage, planar water seepage is also developed well, and partition and equipment box at the entrance and exit of tunnel are prone to water seepage; construction stage is crucial for controlling water damage to loess double-arched tunnel, atmospheric precipitation is the main water source, and the structure defect of double-arched tunnel increases the possibility of water seepage; the final sequence for weight of various factors is similar to the actual result.

  16. Balancing repair and tolerance of DNA damage caused by alkylating agents

    OpenAIRE

    Fu, Dragony; Calvo, Jennifer A.; Samson, Leona D.

    2012-01-01

    Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision repair (BER) and mismatch repair (MMR), respond to alkylation damage to defend against alkylation-induced cell death or mutation. However, maintaining a proper balance of activity both within and between these pathways is crucial ...

  17. SERIES: Genomic instability in cancer Balancing repair and tolerance of DNA damage caused by alkylating agents

    OpenAIRE

    Fu, Dragony; Calvo, Jennifer A.; Samson, Leona D

    2012-01-01

    Alkylating agents comprise a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision repair (BER), and mismatch repair (MMR) respond to alkylation damage to defend against alkylation-induced cell death or mutation. However, maintaining a proper balance of activity both within and between these pathways is crucial fo...

  18. A methodology for the economic assessment of material damage caused by SO2 and NOx emissions in Europe

    International Nuclear Information System (INIS)

    Mayerhofer, P.; Weltschev, M.; Trukenmueller, A.; Friedrich, R.

    1995-01-01

    Damage to materials causes high economic losses in Europe. A large part of this damage can be attributed to the emissions caused by the energy and the transport sector. In the paper, the procedure for the economic assessment of material damages caused by SO 2 and NO x emissions in Europe is described. Model and data requirements are outlined, and gaps and uncertainties of the quantification are discussed. Two types of results are presented. First, the marginal (additional) costs of damage to material caused by an additional power plant are assessed. The analysis covers plants with different technologies. Results for the fossil power plants are in the range of 0.0062 to 0.12 mECU/kWh. In addition, the total economic material damage due to the present air pollution was assessed. It is in the range of 2.9 to 5.3 x 10 9 ECU/year. However, the analysis has many uncertainties. Most noteworthy are the material inventories and partially the damage functions and input data. 15 refs., 1 fig., 1 tab

  19. Meta-Analysis of Attitudes toward Damage-Causing Mammalian Wildlife

    Science.gov (United States)

    KANSKY, RUTH; KIDD, MARTIN; KNIGHT, ANDREW T

    2014-01-01

    Many populations of threatened mammals persist outside formally protected areas, and their survival depends on the willingness of communities to coexist with them. An understanding of the attitudes, and specifically the tolerance, of individuals and communities and the factors that determine these is therefore fundamental to designing strategies to alleviate human-wildlife conflict. We conducted a meta-analysis to identify factors that affected attitudes toward 4 groups of terrestrial mammals. Elephants (65%) elicited the most positive attitudes, followed by primates (55%), ungulates (53%), and carnivores (44%). Urban residents presented the most positive attitudes (80%), followed by commercial farmers (51%) and communal farmers (26%). A tolerance to damage index showed that human tolerance of ungulates and primates was proportional to the probability of experiencing damage while elephants elicited tolerance levels higher than anticipated and carnivores elicited tolerance levels lower than anticipated. Contrary to conventional wisdom, experiencing damage was not always the dominant factor determining attitudes. Communal farmers had a lower probability of being positive toward carnivores irrespective of probability of experiencing damage, while commercial farmers and urban residents were more likely to be positive toward carnivores irrespective of damage. Urban residents were more likely to be positive toward ungulates, elephants, and primates when probability of damage was low, but not when it was high. Commercial and communal farmers had a higher probability of being positive toward ungulates, primates, and elephants irrespective of probability of experiencing damage. Taxonomic bias may therefore be important. Identifying the distinct factors explaining these attitudes and the specific contexts in which they operate, inclusive of the species causing damage, will be essential for prioritizing conservation investments. Meta-Análisis de las Posturas hacia la Mam

  20. Polymyxin B causes DNA damage in HK-2 cells and mice.

    Science.gov (United States)

    Yun, B; Zhang, T; Azad, M A K; Wang, J; Nowell, C J; Kalitsis, P; Velkov, T; Hudson, D F; Li, J

    2018-03-20

    Increasing incidence of multidrug-resistant bacteria presents an imminent risk to global health. Polymyxins are 'last-resort' antibiotics against Gram-negative 'superbugs'; however, nephrotoxicity remains a key impediment in their clinical use. Molecular mechanisms underlying this nephrotoxicity remain poorly defined. Here, we examined the pathways which led to polymyxin B induced cell death in vitro and in vivo. Human proximal tubular cells were treated with polymyxin B (12.5-100 μM) for up to 24 h and showed a significant increase in micronuclei frequency, as well as abnormal mitotic events (over 40% in treated cells, p < 0.05). Time-course studies were performed using a mouse nephrotoxicity model (cumulative 72 mg/kg). Kidneys were collected over 48 h and investigated for histopathology and DNA damage. Notable increases in γH2AX foci (indicative of double-stranded breaks) were observed in both cell culture (up to ~ 44% cells with 5+ foci at 24 h, p < 0.05) and mice treated with polymyxin B (up to ~ 25%, p < 0.05). Consistent with these results, in vitro assays showed high binding affinity of polymyxin B to DNA. Together, our results indicate that polymyxin B nephrotoxicity is associated with DNA damage, leading to chromosome missegregation and genome instability. This novel mechanistic information may lead to new strategies to overcome the nephrotoxicity of this important last-line class of antibiotics.

  1. Influence of damage caused by Kr ions and neutrons on electrical properties of silicon detectors

    International Nuclear Information System (INIS)

    Croitoru, N.; Gubbini, E.; Rancoita, P.G.; Rattaggi, M.; Seidman, A.

    1999-01-01

    In this paper, new measurements of physical properties of high-resistivity silicon, used in high-energy detectors, are presented. The obtained data contribute to the understanding of the causes which damage the 2electronic characteristics of the detection systems under irradiation of neutrons and ionized particles (Kr). The Hall effect coefficient (R H ) and resistivity (ρ) measurements as a function of temperature (T), for non-irradiated and irradiated by neutrons and Kr ions, were performed. The measurements of the Hall coefficient and resistivity of non-irradiated samples and irradiated at neutron fluences (PHI≤9.9x10 10 n/cm 2 ) and Kr (PHI≤7.5x10 8 Kr/cm 2 ), have shown that the obtained characteristics, R H (T) and ρ(T), are of the same shape as those known for a silicon single crystal. A slight difference of the slope of ln ρ∼ln T, for neutron- and a large difference for Kr ion irradiation as compared with that of non-irradiated samples, was observed. On increasing the irradiation to PHI larger than the value indicated above, for neutrons and Kr ions, important changes in the physical properties were observed. The resistivity increases with increasing PHI, up to a value of the same order with intrinsic silicon (ρ∼10 5 Ω cm), for both neutron and Kr ion irradiation. The values of R H increase with increasing PHI up to a fluence, for which a change of sign, from negative to positive, occurs. The variation of values of R H and ρ as a function of PHI, for neutrons and Kr ions, is similar, but the characteristics R H (PHI) and ρ(PHI), are displaced. Therefore, larger values of PHI are needed in order to obtain the same values of ρ as those for Kr ion irradiation. The dependence on T of electrical parameters of samples, irradiated at PHI≥9.9x10 10 n/cm 2 (neutrons) and PHI≥7.5x10 8 Kr/cm 3 (ions), cannot be explained, considering the usual theoretical relations. The results, obtained in these experiments, have shown a change of mechanism of

  2. Mechanisms involved in reproductive damage caused by gossypol in rats and protective effects of vitamin E

    Directory of Open Access Journals (Sweden)

    Andréia T Santana

    2015-01-01

    Full Text Available BACKGROUND: Gossypol is a chemical present in the seeds of cotton plants (Gossypium sp. that reduces fertility in farm animals. Vitamin E is an antioxidant and may help to protect cells and tissues against the deleterious effects of free radicals. The aim of this study was to evaluate the mechanisms of reproductive toxicity of gossypol in rats and the protective effects of vitamin E. Forty Wistar rats were used, divided into four experimental groups (n = 10: DMSO/ saline + corn oil; DMSO/saline + vitamin E; gossypol + corn oil; and gossypol + vitamin E. RESULTS: Fertility was significantly reduced in male rats treated with gossypol in that a significant decrease in epididy-mal sperm count was observed (P 0.05. The levels of reduced glutathione and pyridine nucleotides in testis homogen-ate were significantly reduced by gossypol (P < 0.05 and P < 0.01, respectively and this reduction was accompanied by increased levels of oxidized glutathione (P < 0.05. Vitamin E showed a preventive effect on the changes in the levels of these substances. Gossypol significantly increased the levels of malondialdehyde (P < 0.01, a lipid peroxida-tion indicator, whereas treatment with vitamin E inhibited the action of the gossypol. Vitamin E prevented a decrease in mitochondrial ATP induced by gossypol (P < 0.05. CONCLUSIONS: This study suggests that the reproductive dysfunction caused by gossypol may be related to oxidative stress and mitochondrial bioenergetic damage and that treatment with vitamin E can prevent the infertility caused by the toxin.

  3. Does vitamin E prevent tubal damage caused by smoking? A light microscopy and animal study.

    Science.gov (United States)

    Duran, Muzeyyen; Ustunyurt, Emin; Kosus, Aydin; Kosus, Nermin; Turhan, Nilgun; Hızlı, Deniz; Sarac, Gulce Naz; Erdogan, Deniz

    2014-04-01

    To assess the histomorphological effects of smoking on the cilia of fallopian tubes in mice and the effect of vitamin E on the negative effects of smoke. Eighteen 12-14 week-old Swiss albino type female mice were randomly divided into three groups, each consisting of six mice: Group A: control group; Group B: mice exposed to cigarette smoke; Group C: mice exposed to cigarette smoke together with vitamin E. Groups B and C were exposed to cigarette smoke for 10 weeks. After 10 weeks, tubal excision was performed in all animals. Histopathologic examination of excised tubal tissue was conducted under light microscopy. The number of cilia was significantly lower in Group B. Although not statistically significant, the median number of cilia in Group C was measured to be higher than in Group B but lower than in Group A. Based on the results, it can be concluded that smoking decreases tubal cilia numbers. Supplementation by vitamin E may treat or at least help to slow down the decrease in number of cilia caused by smoking; therefore it could be used therapeutically in the treatment of smoking-related tubal damage. Crown Copyright © 2014. Published by Elsevier Ireland Ltd. All rights reserved.

  4. A Fatal Waterborne Outbreak of Pesticide Poisoning Caused by Damaged Pipelines, Sindhikela, Bolangir, Orissa, India, 2008

    International Nuclear Information System (INIS)

    Panda, M.; Hutin, Y.J.; Ramachandran, V.; Murhekar, M.; Panda, M.; Hutin, Y.J.

    2009-01-01

    Introduction. We investigated a cluster of pesticide poisoning in Orissa. Methods. We searched the village for cases of vomiting and sweating on 2 February 2008. We described the outbreak by time, place, and person. We compared cases with controls. Results. We identified 65 cases (two deaths; attack rate: 12 per 1000; case fatality: 3%). The epidemic curve suggested a point source outbreak, and cases clustered close to a roadside eatery. Consumption of water from a specific source (odds ratio [OR]: 35, confidence interval [CI]: 13 93) and eating in the eatery (OR: 2.3, CI: 1.14.7) was associated with illness. On 31 January 2008, villagers had used pesticides to kill street dogs and had discarded leftovers in the drains. Damaged pipelines located beneath and supplying water may have aspirated the pesticide during the nocturnal negative pressure phase and rinsed it off the next morning in the water supply. Conclusions. Inappropriate use of pesticides contaminated the water supply and caused this outbreak. Education programs and regulations need to be combined to ensure a safer use of pesticides in India.

  5. Microdosimetric constraints on specific adaptation mechanisms to reduce DNA damage caused by ionising radiation

    International Nuclear Information System (INIS)

    Burkart, W.; Heusser, P.; Vijayalaxmi

    1990-01-01

    The protective effect of pre-exposure of lymphocytes to ionising radiation indicates the presence of 'adaptive repair' in mammalian cells. Microdosimetric considerations, however, raise some doubts on the advantage of such a cellular mechanism for specifically reducing the radiation damage caused by environmental exposures. Contrary to most chemicals which endanger the integrity of the mammalian genome, the local dose and dose rate from ionising radiation at the cellular level remain quite high, even at lowest exposures. A single electron or alpha particle passing through a cell nucleus already yields nuclear doses of up to about 3 mGy and 400 mGy, respectively. Macroscopic doses below these nuclear doses from a single event will only reduce the fraction of cell nuclei encountering the passage of a particle but not the dose or dose rate in the affected volume. At environmental doses in the range of 1 to 5 mGy per annum, the time between two consecutive hits in a specific cell nucleus is in the range of months to years. Very low concentrations of bleomycin, a drug with high affinity to DNA, also triggers an adaptive response. This points to a more general stress response mechanism which may benefit the cell even at environmental levels of radioactivity, e.g. by protecting the integrity of DNA from attacks by chemicals, by endogenous radicals, by acids from anoxia, etc. (author)

  6. Damage caused to our forests and its control up to 1918

    Energy Technology Data Exchange (ETDEWEB)

    Nozicka, J

    1963-01-01

    Air pollution was mentioned as soon as 1699 by Chr. Lehman, chronicler of Krusne hory and its injurious effects were observed since the thirties of the nineteenth century by brothers Baar on their plot situated in the neighborhood of a manufactory chimney at Kdyne near Klatovy, as well as since 1843 by the surveyor William Rowland in managing the town forest of Pribram in the surroundings of silver works at Brezove hory. The problem of damage caused to our forests by air pollution arose the interest of our foresters 1850, when at the conference of the Bohemian Forestry Union held in Decin Rowland read a paper on air pollution in the area of Pribram and in surroundings of a brick-kiln at Zdiky in the Kaplice region. After 1853, the smoke effects began to be apparent in the Jachymov region, since 1880 in the Ostrava region, since the nineties of the past century in the Sokolovo, Loket, Karlovy Vary, Usti n. L. and Nachod regions and, since the first decade of the present century in the Bilina and Kladno regions. It was found that silver fir, Norway spruce and Scotch pine were the most sensitive species to smoke, whereas European larch proved to be very resistant. Broadleaved species showed also a good growth in the smoke affected areas. Basing on this experience, our foresters tried, therefore, to reduce the injouris smoke effects by growing broadleaved species in those areas. 12 references.

  7. Exposure to nano-size titanium dioxide causes oxidative damages in human mesothelial cells: The crystal form rather than size of particle contributes to cytotoxicity.

    Science.gov (United States)

    Hattori, Kenji; Nakadate, Kazuhiko; Morii, Akane; Noguchi, Takumi; Ogasawara, Yuki; Ishii, Kazuyuki

    2017-10-14

    Exposure to nanoparticles such as carbon nanotubes has been shown to cause pleural mesothelioma similar to that caused by asbestos, and has become an environmental health issue. Not only is the percutaneous absorption of nano-size titanium dioxide particles frequently considered problematic, but the possibility of absorption into the body through the pulmonary route is also a concern. Nevertheless, there are few reports of nano-size titanium dioxide particles on respiratory organ exposure and dynamics or on the mechanism of toxicity. In this study, we focused on the morphology as well as the size of titanium dioxide particles. In comparing the effects between nano-size anatase and rutile titanium dioxide on human-derived pleural mesothelial cells, the anatase form was shown to be actively absorbed into cells, producing reactive oxygen species and causing oxidative damage to DNA. In contrast, we showed for the first time that the rutile form is not easily absorbed by cells and, therefore, does not cause oxidative DNA damage and is significantly less damaging to cells. These results suggest that with respect to the toxicity of titanium dioxide particles on human-derived mesothelial cells, the crystal form rather than the particle size has a greater effect on cellular absorption. Also, it was indicated that the difference in absorption is the primary cause of the difference in the toxicity against mesothelial cells. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Exploiting Scanning Behavior for Predators Can Reduce Rice Damage Caused by Birds

    Directory of Open Access Journals (Sweden)

    Takeshi Honda

    2015-01-01

    Full Text Available Rice is often damaged by birds, especially sparrows, in Asia. Bird nets are sometimes used as countermeasures; however this approach is expensive and labor intensive. For this reason, farmers generally eschew bird nets, even though no alternative countermeasures are available. This study focused on exploiting the bird behavior of scanning for predators to reduce crop damage. When birds forage for seeds on the ground they often stop pecking and briefly raise their heads, apparently to scan for predators. Low visibility habitats increase scanning behavior and increased scanning behavior reduces habitat quality from the bird’s perspective; therefore, this study tested the relationship between rice damage rate and visibility at the periphery of rice fields, where tree sparrows rest after feeding. Overall, low visibility reduced damage to rice. Because visibility was mainly affected by weeds, weed management techniques contribute to crop damage management. To reduce damage, weeding can be decreased; therefore, this technique is cost- and labor-efficient.

  9. Psychological health damage as an environmental effect: Metropolitan Edison Co. v. People Against Nuclear Energy

    International Nuclear Information System (INIS)

    Hoff, E.H.

    1984-01-01

    The Supreme court took a narrow view of the term environmental in Metropolitan Edison Co. v. People Against Nuclear Energy when it stated that the purpose of the National Environmental Policy Act (NEPA) is to protect the physical environment. Psychological health damage caused by the perception of the risk of a nuclear accident is not an environmental effect cognizable under NEPA unless their is a demonstrable relationship. Litigants seeking the protection of NEPA must carefully examine the origin and nature of alleged psychological harms and frame their complains to establish a close relationship between a change in the physical environment and the alleged psychological harm

  10. SERIES: Genomic instability in cancer Balancing repair and tolerance of DNA damage caused by alkylating agents

    Science.gov (United States)

    Fu, Dragony; Calvo, Jennifer A.; Samson, Leona D

    2013-01-01

    Alkylating agents comprise a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision repair (BER), and mismatch repair (MMR) respond to alkylation damage to defend against alkylation-induced cell death or mutation. However, maintaining a proper balance of activity both within and between these pathways is crucial for an organism's favorable response to alkylating agents. Furthermore, an individual's response to alkylating agents can vary considerably from tissue to tissue and from person to person, pointing to genetic and epigenetic mechanisms that modulate alkylating agent toxicity. PMID:22237395

  11. Achieving health equity: from root causes to fair outcomes.

    Science.gov (United States)

    Marmot, Michael

    2007-09-29

    Health is a universal human aspiration and a basic human need. The development of society, rich or poor, can be judged by the quality of its population's health, how fairly health is distributed across the social spectrum, and the degree of protection provided from disadvantage due to ill-health. Health equity is central to this premise and to the work of the Commission on Social Determinants of Health. Strengthening health equity--globally and within countries--means going beyond contemporary concentration on the immediate causes of disease. More than any other global health endeavour, the Commission focuses on the "causes of the causes"--the fundamental structures of social hierarchy and the socially determined conditions these create in which people grow, live, work, and age. The time for action is now, not just because better health makes economic sense, but because it is right and just. The outcry against inequity has been intensifying for many years from country to country around the world. These cries are forming a global movement. The Commission on Social Determinants of Health places action to ensure fair health at the head and the heart of that movement.

  12. Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1

    Directory of Open Access Journals (Sweden)

    Yinliang Zhang

    2017-01-01

    . Conclusions: Celastrol ameliorates NAFLD by decreasing lipid synthesis and improving the anti-oxidative and anti-inflammatory status. And Sirt1 has an important role in Celastrol-ameliorating liver metabolic damage caused by HFD. Keywords: Nonalcoholic fatty liver disease, Celastrol, Sirt1, Lipid metabolism, Chronic inflammation, Oxidative stress

  13. Guidance on the scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health

    DEFF Research Database (Denmark)

    Tetens, Inge

    2011-01-01

    The Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked by the European Food Safety Authority (EFSA) t to draft guidance on scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health. This guidance has been drawn from scientific...... opinions of the NDA Panel on such health claims. Thus, this guidance document represents the views of the NDA Panel based on the experience gained to date with the evaluation of health claims in these areas. It is not intended that the document should include an exhaustive list of beneficial effects...

  14. Finding peace from Hiroshima. One oncologist's fight to rectify the damage caused by radiation

    International Nuclear Information System (INIS)

    Skoufalos, M.N.

    2006-01-01

    The article informs about one oncologist's fight to rectify the damage caused by radiation. In a small town just outside Osaka, Japan, Ritsuko Komaki was born, quite literally, into the atomic age. She was just an infant in 1945 when the first atomic bomb ever detonated on a human population devastated her family's ancestral home of Hiroshima. One of her friends, Sasaki was diagnosed with leukemia, and was later hospitalized with bone marrow suppression. Her grandmother had been exposed to the same chemical radiation that Sasaki had, yet never contracted leukemia despite presenting with all the other side effects of exposure. Komaki wa wondering why her grandmother never had any leukemia, but Sadako did? She never had any cancer, but she had all the symptoms of exposure, e.g. hair loss, diarrhea and bone marrow problems. During medical school, Komaki volunteered her summers at the Atomic Bomb Casualty Commission, the institute the United States built in Japan to examine the victims of atomic exposure. Anyone diagnosed as anemic underwent a bone marrow exam, and Komaki learned a great deal about chromosomal abnormalities by performing blood tests alongside visiting researchers from Yale University and other American hospitals. The bombings of Hiroshima and Nagasaki had fostered a national paranoia about radiation and radioactivity. In Japan, they hate radiation, and for so many years, they did not want to hear about radiation therapy. Patients had an illogical fear of it that delayed offering it as treatment there. In Japan, the majority of cancer treatment culminated in surgery. Radiation oncology was not a recognized specialization; oncologists were grouped in with diagnostic radiation techs. Yet today, Ritsuko Komaki, MD, is the chief operating officer of one of the most sophisticated radiation oncology treatment facilities in the United States: the 120 million US Dollar M.D. Anderson Cancer Center in Houston. And ironically, the technical equipment that forms

  15. Geological structure of Osaka basin and characteristic distributions of structural damage caused by earthquake; Osaka bonchi kozo to shingai tokusei

    Energy Technology Data Exchange (ETDEWEB)

    Nakagawa, K; Shiono, K; Inoue, N; Senda, S [Osaka City University, Osaka (JP. Faculty of Science); Ryoki, K [Osaka Polytechnic Collage, Osaka (Japan); Shichi, R [Nagoya University, Nagoya (Japan). Faculty of Science

    1996-05-01

    The paper investigates relations between the damage caused by the Hyogo-ken Nanbu earthquake and the deep underground structures. A characteristic of the earthquake damage distribution is that the damage concentrated near faults. Most of the damages were seen on the side of faults` relatively falling rather than right above the faults and of their slightly slanting to the seaside. Distribution like this seems to be closely related to underground structures. Therefore, a distribution map of the depth of basement granite in Osaka sedimentary basin was drawn, referring to the data on basement rock depth obtained from the distribution map of gravity anomaly and the result of the survey using the air gun reflection method. Moreover, cubic underground structures were determined by 3-D gravity analysis. The result was concluded as follows: when observing the M7 zone of the low land, in particular, where the damage was great from an aspect of gravity anomaly, the basement rock below the zone declined near the cliff toward the sea, which indicates a great possibility of its being a fault. There is a high possibility that the zone suffered mostly from the damage caused by focusing by refraction and total reflection of seismic wave rays. 3 refs., 8 figs.

  16. Schinus terebinthifolius Leaf Extract Causes Midgut Damage, Interfering with Survival and Development of Aedes aegypti Larvae.

    Science.gov (United States)

    Procópio, Thamara Figueiredo; Fernandes, Kenner Morais; Pontual, Emmanuel Viana; Ximenes, Rafael Matos; de Oliveira, Aline Rafaella Cardoso; Souza, Carolina de Santana; Melo, Ana Maria Mendonça de Albuquerque; Navarro, Daniela Maria do Amaral Ferraz; Paiva, Patrícia Maria Guedes; Martins, Gustavo Ferreira; Napoleão, Thiago Henrique

    2015-01-01

    In this study, a leaf extract from Schinus terebinthifolius was evaluated for effects on survival, development, and midgut of A. aegypti fourth instar larvae (L4), as well as for toxic effect on Artemia salina. Leaf extract was obtained using 0.15 M NaCl and evaluated for phytochemical composition and lectin activity. Early L4 larvae were incubated with the extract (0.3-1.35%, w/v) for 8 days, in presence or absence of food. Polymeric proanthocyanidins, hydrolysable tannins, heterosid and aglycone flavonoids, cinnamic acid derivatives, traces of steroids, and lectin activity were detected in the extract, which killed the larvae at an LC50 of 0.62% (unfed larvae) and 1.03% (fed larvae). Further, the larvae incubated with the extract reacted by eliminating the gut content. No larvae reached the pupal stage in treatments at concentrations between 0.5% and 1.35%, while in the control (fed larvae), 61.7% of individuals emerged as adults. The extract (1.0%) promoted intense disorganization of larval midgut epithelium, including deformation and hypertrophy of cells, disruption of microvilli, and vacuolization of cytoplasms, affecting digestive, enteroendocrine, regenerative, and proliferating cells. In addition, cells with fragmented DNA were observed. Separation of extract components by solid phase extraction revealed that cinnamic acid derivatives and flavonoids are involved in larvicidal effect of the extract, being the first most efficient in a short time after larvae treatment. The lectin present in the extract was isolated, but did not show deleterious effects on larvae. The extract and cinnamic acid derivatives were toxic to A. salina nauplii, while the flavonoids showed low toxicity. S. terebinthifolius leaf extract caused damage to the midgut of A. aegypti larvae, interfering with survival and development. The larvicidal effect of the extract can be attributed to cinnamic acid derivatives and flavonoids. The data obtained using A. salina indicates that caution

  17. Schinus terebinthifolius Leaf Extract Causes Midgut Damage, Interfering with Survival and Development of Aedes aegypti Larvae.

    Directory of Open Access Journals (Sweden)

    Thamara Figueiredo Procópio

    Full Text Available In this study, a leaf extract from Schinus terebinthifolius was evaluated for effects on survival, development, and midgut of A. aegypti fourth instar larvae (L4, as well as for toxic effect on Artemia salina. Leaf extract was obtained using 0.15 M NaCl and evaluated for phytochemical composition and lectin activity. Early L4 larvae were incubated with the extract (0.3-1.35%, w/v for 8 days, in presence or absence of food. Polymeric proanthocyanidins, hydrolysable tannins, heterosid and aglycone flavonoids, cinnamic acid derivatives, traces of steroids, and lectin activity were detected in the extract, which killed the larvae at an LC50 of 0.62% (unfed larvae and 1.03% (fed larvae. Further, the larvae incubated with the extract reacted by eliminating the gut content. No larvae reached the pupal stage in treatments at concentrations between 0.5% and 1.35%, while in the control (fed larvae, 61.7% of individuals emerged as adults. The extract (1.0% promoted intense disorganization of larval midgut epithelium, including deformation and hypertrophy of cells, disruption of microvilli, and vacuolization of cytoplasms, affecting digestive, enteroendocrine, regenerative, and proliferating cells. In addition, cells with fragmented DNA were observed. Separation of extract components by solid phase extraction revealed that cinnamic acid derivatives and flavonoids are involved in larvicidal effect of the extract, being the first most efficient in a short time after larvae treatment. The lectin present in the extract was isolated, but did not show deleterious effects on larvae. The extract and cinnamic acid derivatives were toxic to A. salina nauplii, while the flavonoids showed low toxicity. S. terebinthifolius leaf extract caused damage to the midgut of A. aegypti larvae, interfering with survival and development. The larvicidal effect of the extract can be attributed to cinnamic acid derivatives and flavonoids. The data obtained using A. salina indicates

  18. Green Tea Polyphenols for the Protection against Renal Damage Caused by Oxidative Stress

    Directory of Open Access Journals (Sweden)

    Takako Yokozawa

    2012-01-01

    Full Text Available Green tea, prepared from the leaves of Camellia sinensis L., is a beverage that is popular worldwide. Polyphenols in green tea have been receiving much attention as potential compounds for the maintenance of human health due to their varied biological activity and low toxicity. In particular, the contribution of antioxidant activity to the prevention of diseases caused by oxidative stress has been focused upon. Therefore, in this study, we investigated the effects of (−-epigallocatechin 3-O-gallate and (−-epigallocatechin 3-O-gallate, which account for a large fraction of the components of green tea polyphenol, on oxidative stress-related renal disease. Our observations suggest that green tea polyphenols have a beneficial effect on pathological states related to oxidative stress of the kidney.

  19. Oviposition punctures in cucurbit fruits and their economic damage caused by the sterile female melon fly, Bactrocera cucurbitae Coquillett

    International Nuclear Information System (INIS)

    Miyatake, T.; Irabu, T.; Higa, R.

    1993-01-01

    Oviposition punctures caused by sterile females of the tephritid Bactrocera cucurbitae in cucurbit fruits were examined and economic damage was evaluated in Okinawa, Ryukyu Archipelago, Japan. Cage experiments in the field confirmed that sterile females make punctures (sterile stings) on fruits. The features of sterile stings differed depending on fruit species and were classified into 5 types

  20. Damage caused by Tetranychus Merganser Bondreaux (Acari: Tetranychidae on Nopal Verdura Opuntia Ficus-Indica (L. Miller during winter

    Directory of Open Access Journals (Sweden)

    J. Lima-Espíndola

    2017-09-01

    Full Text Available The spider mite Tetranychus merganser occurs in some crops in Mexico and USA. This mite could be considered a potential pest in countries like Japan. In this work we recorded the damages that T. merganser causes to the nopal verdura (prickly pear vegetable crop in one of the principal cactus crop regions of Mexico.

  1. Balancing repair and tolerance of DNA damage caused by alkylating agents.

    Science.gov (United States)

    Fu, Dragony; Calvo, Jennifer A; Samson, Leona D

    2012-01-12

    Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision repair (BER) and mismatch repair (MMR), respond to alkylation damage to defend against alkylation-induced cell death or mutation. However, maintaining a proper balance of activity both within and between these pathways is crucial for a favourable response of an organism to alkylating agents. Furthermore, the response of an individual to alkylating agents can vary considerably from tissue to tissue and from person to person, pointing to genetic and epigenetic mechanisms that modulate alkylating agent toxicity.

  2. Radiation Damage in Silicon Detectors Caused by Hadronic and Electromagnetic Irradiation

    CERN Document Server

    Fretwurst, E.; Stahl, J.; Pintilie, I.

    2002-01-01

    The report contains various aspects of radiation damage in silicon detectors subjected to high intensity hadron and electromagnetic irradiation. It focuses on improvements for the foreseen LHC applications, employing oxygenation of silicon wafers during detector processing (result from CERN-RD48). An updated survey on hadron induced damage is given in the first article. Several improvements are outlined especially with respect to antiannealing problems associated with detector storage during LHC maintenance periods. Open questions are outlined in the final section, among which are a full understanding of differences found between proton and neutron induced damage, process related effects changing the radiation tolerance in addition to the oxygen content and the lack of understanding the changed detector properties on the basis of damage induced point and cluster defects. In addition to float zone silicon, so far entirely used for detector fabrication,Czochralski silicon was also studied and first promising re...

  3. Impact of oxygen concentration on yields of DNA damages caused by ionizing radiation

    Czech Academy of Sciences Publication Activity Database

    Štěpán, Václav; Davídková, Marie

    2008-01-01

    Roč. 101, 012015 (2008), s. 1-4 ISSN 1742-6588. [Radiation Damage in Biomolecular Systems, RADAM'07. Dublin, 19.06.2007-22.06.2007] R&D Projects: GA ČR(CZ) GD202/05/H031; GA ČR GA202/05/2728 Institutional research plan: CEZ:AV0Z10480505 Keywords : radiation damage to DNA * oxygen concentration * theoretical modeling Subject RIV: BO - Biophysics

  4. Indemnification of damage to the environment caused by non-nuclear industrial activities

    International Nuclear Information System (INIS)

    Smets, H.

    1985-01-01

    Environmental damage has reached catastrophic proportions, implying the death of hundreds of people or expenses of many hundreds of million dollars. The financial impact of this damage is however small at the level of the industrial sector concerned which could bear its costs. If States would take measures to redistribute such costs, they would avoid having to compensate victims of the gravest accidents. Special procedures were introduced for this purpose in certain industrial sectors. (NEA) [fr

  5. Could humic acid relieve the biochemical toxicities and DNA damage caused by nickel and deltamethrin in earthworms (Eisenia foetida)?

    Science.gov (United States)

    Shen, Chen-Chao; Shen, Dong-Sheng; Shentu, Jia-Li; Wang, Mei-Zhen; Wan, Ming-Yang

    2015-12-01

    The aim of the study was to determine whether humic acid (HA) prevented gene and biochemical toxic effects in earthworms (Eisenia foetida) exposed to nickel and deltamethrin (at 100 and 1 mg kg(-1), respectively) in soil. Cellular- and molecular-level toxic effects of nickel and deltamethrin in earthworms were evaluated by measuring damage to lipid membranes and DNA and the production of protein carbonyls over 42 days of exposure. Nickel and deltamethrin induced significant levels of oxidative stress in earthworms, increasing the production of peroxidation products (malondialdehyde and protein carbonyls) and increasing the comet assay tail DNA% (determined by single-cell gel electrophoresis). DNA damage was the most sensitive of the three indices because it gave a higher sample/control ratio than did the other indices. The presence of HA alleviated (in decreasing order of effectiveness) damage to DNA, proteins, and lipid membranes caused by nickel and deltamethrin. A low HA dose (0.5-1% HA in soil) prevented a great deal of lipid membrane damage, but the highest HA dose (3% HA in soil) prevented still more DNA damage. However, the malondialdehyde concentrations in earthworms were higher at the highest HA dose than at the lower HA doses. The amounts of protein carbonyls produced at different HA doses were not significantly different. The toxic effects to earthworms caused by increased oxidizable nickel concentrations could be relieved by adding HA.

  6. Damage of rat liver tissue caused by repeated and sustained +Gz exposure and the mechanism thereof

    Directory of Open Access Journals (Sweden)

    Wen-bing LI

    2014-03-01

    Full Text Available Objective  To explore the mechanisms of positive acceleration (+Gz on the damage of rat liver tissue and the effect of +Gz on the expression of JNK/c-Jun in liver cells. Methods  Twenty four male Wistar rats were randomly divided into 4 groups (n=6: control, +2Gz, +6Gz and +10Gz group. With prone position, the rats in control group were fixed to the turning arm of centrifuge with head towards the axis for 5 minutes. The fixation method in +2Gz, +6Gz and +10Gz group was the same as in the control group. The increase rate of acceleration was 1G/s with a peak-time of 3 minutes, and each +Gz exposure repeated 5 times with an interval of 30 minutes. HE staining was used to observe the morphological changes of liver tissue, fluorescence real-time quantitative PCR to detect the expression of hepatic c-Jun mRNA, and Western blotting to detect the hepatic protein expression of p-c-Jun, c-Jun, p-JNK and JNK. Plasma aspartate aminotransferase (AST and alanine aminotransferase (ALT were determined. Results  The levels of serum ALT and AST increased significantly in +6Gz and, especially, the +10Gz group than in control group and +2Gz group (P<0.05. The same situation also existed in the increase of c-Jun mRNA expression (P<0.05. Hepatic c-jun and p-c-Jun (c-Jun activated form protein expression increased with the increase of G value. Compared with control group, no change was found in JNK protein expression in the other three groups, but the expression of p-JNK (activated form of JNK increased in +6Gz and +10Gz groups (P<0.05. HE staining showed the disorganized liver cells with irregular shapes, the unclear cell gap and the vacuolar changes in +6Gz and +10Gz groups. Conclusions  Repeated and sustained +Gz may cause enhanced expression of c-Jun/ p-c-Jun and p-JNK in hepatic cells. JNK/c-Jun signaling pathway may play an important role in the process of hepatic stress injury. DOI: 10.11855/j.issn.0577-7402.2014.03.15

  7. NRC Information Notice No. 92-01: Cable damage caused by inadequate cable installation procedures and controls

    International Nuclear Information System (INIS)

    Rossi, C.E.

    1993-01-01

    In June 1989, the Tennessee Valley Authority (TVA) removed the cables from a conduit in the reactor protection system of the Watts Bar Nuclear Plant, Unit 2, to inspect for damage. TVA selected this conduit in response to an employee's concern that a welding arc that struck the conduit in response to an employee's concern that a welding arc that struck the conduit during construction may have damaged cables in the conduit. When the cables were removed, TVA found significant damage in the insulation of some cables. This damage was not attributed to heat generated by the alleged welding arc. The damage was principally attributed to the pulling stresses exerted during the initial installation of the cables. Some of the cables had insulation removed down to the conductors. To assess the extent of cable damage and determine the scope of its investigation, TVA removed more cables from conduits that constituted the most difficult pulls (worst case) and found varying degrees of damage that it attributed to pulling stresses. To fill a conduit at Watts Bar, personnel used pull cords to pull more cables through the conduits over the top of existing cables. This practice is called ''pull-by.'' This practice can cause damage to the existing cables from the sawing action of the pull cords and the friction of cables as they are pulled over existing cables. TVA instituted programs to assess the adequacy of cable installation at all its nuclear facilities and take appropriate corrective actions. At Watts Bar, TVA replaced cables in conduits which exceeded a calculated threshold value of side wall bearing pressure (SWBP) and performed a high-potential (hi-pot) tests on a number of other cables in conduits with SWBP below the calculated threshold value

  8. Air pollution policies in Europe: efficiency gains from integrating climate effects with damage costs to health and crops

    International Nuclear Information System (INIS)

    Tollefsen, Petter; Rypdal, Kristin; Torvanger, Asbjorn; Rive, Nathan

    2009-01-01

    Emissions of air pollutants cause damage to health and crops, but several air pollutants also have an effect on climate through radiative forcing. We investigate efficiency gains achieved by integrating climate impacts of air pollutants into air quality strategies for the EU region. The pollutants included in this study are SO 2 , NH 3 , VOC, CO, NO x , black carbon, organic carbon, PM 2.5 , and CH 4 . We illustrate the relative importance of climate change effects compared to damage to health and crops, as well as monetary gains of including climate change contributions. The analysis considers marginal abatement costs and compares air quality and climate damage in Euros. We optimize abatement policies with respect to both climate and health impacts, which imply implementing all measures that yield a net benefit. The efficiency gains of the integrated policy are in the order of 2.5 billion Euros, compared to optimal abatement based on health and crop damage only, justifying increased abatement efforts of close to 50%. Climate effect of methane is the single most important factor. If climate change is considered on a 20- instead of a 100-year time-scale, the efficiency gain almost doubles. Our results indicate that air pollution policies should be supplemented with climate damage considerations.

  9. Guidance for the scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health (Revision 1)

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2018-01-01

    of additional health claim applications related to antioxidants, oxidative damage and cardiovascular health, and the information collected from a Grant launched in 2014. This guidance is intended to assist applicants in preparing applications for the authorisation of health claims related to the antioxidants......EFSA asked the Panel on Dietetic Products, Nutrition and Allergies (NDA) to update the guidance on the scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health published in 2011. The update takes into accounts experiences gained with evaluation......, oxidative damage and cardiovascular health. The document was subject to public consultation (from 12 July to 3 September 2017). This document supersedes the guidance on the scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health published in 2011...

  10. Intragastric inulin as a measure of mucosal damage caused by aspirin

    International Nuclear Information System (INIS)

    Wittmers, L.E. Jr.; Anderson, L.A.; Fall, M.M.; Alich, A.A.

    1990-01-01

    In an attempt to find a method of gastric mucosal damage assessment that yields consistent results, the experiments presented here employed the measurement of the movement of inulin out of the gastric contents into the stomach wall and vascular compartment as an estimate of mucosal damage. Anesthetized male Sprague-Dawley rats were functionally nephrectomized and were administered a control or test solution containing 3H-inulin. The test solutions contained one of three doses of aspirin. Blood samples were taken at 15-min intervals over a 90-min exposure period. The stomach was removed from the animal and full-thickness tissue samples taken for measurement of 3H-inulin content. When the gastric mucosa was exposed to the test agents, there was a significantly greater accumulation of inulin in the body and antrum as well as in the plasma when compared to controls. We conclude that intragastric inulin can be employed to estimate gastric mucosal damage

  11. Low doses of ionizing radiation to mammalian cells may rather control than cause DNA damage

    International Nuclear Information System (INIS)

    Feinendegen, L.E.; Sondhaus, C.A.; Altman, K.I.

    1998-01-01

    This report examines the origin of tissue effects that may follow from different cellular responses to low-dose irradiation, using published data. Two principal categories of cellular responses are considered. One response category relates to the probability of radiation-induced DNA damage. The other category consists of low-dose induced metabolic changes that induce mechanisms of DNA damage mitigation, which do not operate at high levels of exposure. Modeled in this way, tissue is treated as a complex adaptive system. The interaction of the various cellular responses results in a net tissue dose-effect relation that is likely to deviate from linearity in the low-dose region. This suggests that the LNT hypothesis should be reexamined. This paper aims at demonstrating tissue effects as an expression of cellular responses, both damaging and defensive, in relation to the energy deposited in cell mass, by use of microdosimetric concepts

  12. Method for assessing damage to mitochondrial DNA caused by radiation and epichlorohydrin

    International Nuclear Information System (INIS)

    Singh, G.; Hauswirth, W.W.; Ross, W.E.; Neims, A.H.

    1985-01-01

    This paper describes a rapid and reliable method for quantification of damage to mitochondrial DNA (mtDNA), especially strand breaks. The degree of damage to mtDNA is assessed by the proportion of physical forms (i.e., supercoiled versus open-circular and linear forms) upon agarose gel electrophoresis, blotting, and visualization by hybridization with [ 32 P]mtDNA probes. The use of a radiolabeled probe is a crucial step in the procedure because it provides both a means to quantify by radioautography and to obtain the mtDNA specificity required to eliminate misinterpretation due to nuclear DNA contamination. To demonstrate the utility of this technique, X-irradiation and epichlorohydrin are shown to damage both isolated mtDNA and mtDNA in whole cells in a dose-dependent fashion

  13. Low doses of ionizing radiation to mammalian cells may rather control than cause DNA damage

    Energy Technology Data Exchange (ETDEWEB)

    Feinendegen, L.E. [Brookhaven National Lab., Upton, NY (United States). Medical Dept.; Bond, V.P. [Washington State Univ., Richland, WA (United States); Sondhaus, C.A. [Univ. of Arizona, Tucson, AZ (United States). Dept. of Radiology and Radiation Control Office; Altman, K.I. [Univ. of Rochester Medical Center, NY (United States). Dept. of Biochemistry and Biophysics

    1998-12-31

    This report examines the origin of tissue effects that may follow from different cellular responses to low-dose irradiation, using published data. Two principal categories of cellular responses are considered. One response category relates to the probability of radiation-induced DNA damage. The other category consists of low-dose induced metabolic changes that induce mechanisms of DNA damage mitigation, which do not operate at high levels of exposure. Modeled in this way, tissue is treated as a complex adaptive system. The interaction of the various cellular responses results in a net tissue dose-effect relation that is likely to deviate from linearity in the low-dose region. This suggests that the LNT hypothesis should be reexamined. This paper aims at demonstrating tissue effects as an expression of cellular responses, both damaging and defensive, in relation to the energy deposited in cell mass, by use of microdosimetric concepts.

  14. Helicobacter pylori Infection Causes Characteristic DNA Damage Patterns in Human Cells

    Directory of Open Access Journals (Sweden)

    Max Koeppel

    2015-06-01

    Full Text Available Infection with the human pathogen Helicobacter pylori (H. pylori is a major risk factor for gastric cancer. Since the bacterium exerts multiple genotoxic effects, we examined the circumstances of DNA damage accumulation and identified regions within the host genome with high susceptibility to H. pylori-induced damage. Infection impaired several DNA repair factors, the extent of which depends on a functional cagPAI. This leads to accumulation of a unique DNA damage pattern, preferentially in transcribed regions and proximal to telomeres, in both gastric cell lines and primary gastric epithelial cells. The observed pattern correlates with focal amplifications in adenocarcinomas of the stomach and partly overlaps with known cancer genes. We thus demonstrate an impact of a bacterial infection directed toward specific host genomic regions and describe underlying characteristics that make such regions more likely to acquire heritable changes during infection, which could contribute to cellular transformation.

  15. Two damaging hydrogeological events in Calabria, September 2000 and November 2015. Comparative analysis of causes and effects

    Science.gov (United States)

    Petrucci, Olga; Caloiero, Tommaso; Aurora Pasqua, Angela

    2016-04-01

    Each year, especially during winter season, some episode of intense rain affects Calabria, the southernmost Italian peninsular region, triggering flash floods and mass movements that cause damage and fatalities. This work presents a comparative analysis between two events that affected the southeast sector of the region, in 2000 and 2014, respectively. The event occurred between 9th and 10th of September 2000 is known in Italy as Soverato event, after the name of the municipality where it reached the highest damage severity. In the Soverato area, more than 200 mm of rain that fell in 24 hours caused a disastrous flood that swept away a campsite at about 4 a.m., killing 13 people and hurting 45. Besides, the rain affected a larger area, causing damage in 89 (out of 409) municipalities of the region. Flooding was the most common process, which damaged housing and trading. Landslide mostly affected the road network, housing and cultivations. The most recent event affected the same regional sector between 30th October and 2nd November 2015. The daily rain recorded at some of the rain gauges of the area almost reached 400 mm. Out of the 409 municipalities of Calabria, 109 suffered damage. The most frequent types of processes were both flash floods and landslides. The most heavily damaged element was the road network: the representative picture of the event is a railway bridge destroyed by the river flow. Housing was damaged too, and 486 people were temporarily evacuated from home. The event also caused a victim killed by a flood. The event-centred study approach aims to highlight differences and similarities in both the causes and the effects of the two events that occurred at a temporal distance of 14 years. The comparative analysis focus on three main aspects: the intensity of triggering rain, the modifications of urbanised areas, and the evolution of emergency management. The comparative analysis of rain is made by comparing the return period of both daily and

  16. Structural Health Monitoring: Numerical Damage Predictor for Composite Structures

    National Research Council Canada - National Science Library

    Lannamann, Daniel

    2001-01-01

    .... Wide use of composites is found in aircraft, armored vehicles, ships and civil structures This present research demonstrates the ability to numerically detect damage in a composite sandwich structure...

  17. Damage Detection Using Lamb Waves for Structural Health Monitoring

    National Research Council Canada - National Science Library

    Crider II, Jeffrey S

    2007-01-01

    .... This study evaluates Lamb wave approaches used to detect simulated cracks in laboratory experiments on thin plates to detect more realistic damage in a test article representing the complex geometry...

  18. Geospatial relationships of tree species damage caused by Hurricane Katrina in south Mississippi

    Science.gov (United States)

    Mark W. Garrigues; Zhaofei Fan; David L. Evans; Scott D. Roberts; William H. Cooke III

    2012-01-01

    Hurricane Katrina generated substantial impacts on the forests and biological resources of the affected area in Mississippi. This study seeks to use classification tree analysis (CTA) to determine which variables are significant in predicting hurricane damage (shear or windthrow) in the Southeast Mississippi Institute for Forest Inventory District. Logistic regressions...

  19. BDNF Regains Function in Hippocampal Long-Term Potentiation Deficits Caused by Diencephalic Damage

    Science.gov (United States)

    Vedder, Lindsey C.; Savage, Lisa M.

    2017-01-01

    Thiamine deficiency (TD), commonly associated with chronic alcoholism, leads to diencephalic damage, hippocampal dysfunction, and spatial learning and memory deficits. We show a decrease in the magnitude of long-term potentiation (LTP) and paired-pulse facilitation (PPF) at CA3-CA1 synapses, independent of sex, following diencephalic damage…

  20. Human papillomavirus type 16 E7 oncoprotein causes a delay in repair of DNA damage

    International Nuclear Information System (INIS)

    Park, Jung Wook; Nickel, Kwangok P.; Torres, Alexandra D.; Lee, Denis; Lambert, Paul F.; Kimple, Randall J.

    2014-01-01

    Background and purpose: Patients with human papillomavirus related (HPV+) head and neck cancers (HNCs) demonstrate improved clinical outcomes compared to traditional HPV negative (HPV−) HNC patients. We have recently shown that HPV+ HNC cells are more sensitive to radiation than HPV− HNC cells. However, roles of HPV oncogenes in regulating the response of DNA damage repair remain unknown. Material and methods: Using immortalized normal oral epithelial cell lines, HPV+ HNC derived cell lines, and HPV16 E7-transgenic mice we assessed the repair of DNA damage using γ-H2AX foci, single and split dose clonogenic survival assays, and immunoblot. The ability of E7 to modulate expression of proteins associated with DNA repair pathways was assessed by immunoblot. Results: HPV16 E7 increased retention of γ-H2AX nuclear foci and significantly decreased sublethal DNA damage repair. While phospho-ATM, phospho-ATR, Ku70, and Ku80 expressions were not altered by E7, Rad51 was induced by E7. Correspondingly, HPV+ HNC cell lines showed retention of Rad51 after γ-radiation. Conclusions: Our findings provide further understanding as to how HPV16 E7 manipulates cellular DNA damage responses that may underlie its oncogenic potential and influence the altered sensitivity to radiation seen in HPV+ HNC as compared to HPV− HNC

  1. Causes of keel bone damage and their solutions in laying hens

    NARCIS (Netherlands)

    Harlander-Matauschek, A.; Rodenburg, T.B.; Sandilands, V.; Tobalske, B.W.; Toscano, M.J.

    2015-01-01

    Keel bone damage (KBD) is a critical issue facing the contemporary laying hen industry due to the likely pain leading to compromised welfare and reduced productivity. Recent reports suggest that KBD, while highly variable and likely dependent on a host of factors, extends to all housing systems

  2. Field data analysis of asphalt road paving damages caused by tree roots

    Science.gov (United States)

    Weissteiner, Clemens; Rauch, Hans Peter

    2015-04-01

    Tree root damages are a frequent problem along paved cycling paths and service roads of rivers and streams. Damages occur mostly on streets with thin asphalt layers and especially in the upper part of the pavement structure. The maintainers of these roads are faced with frequent and high annual repair costs in order to guarantee traffic safety and pleasant cycling conditions. The focus of this research project is to get an insight in the processes governing the growth of the tree roots in asphalt layers and to develop test methods to avoid rood penetration into the road structure. Tree vegetation has been analysed selectively along a 300 km long cycle and service path of the Danube River in the region of Austria. Tree characteristics, topographic as well as hydrologic conditions have been analysed at 119 spots with different asphalt damage intensities. On 5 spots additional investigations on the root growth characteristics where performed. First results underline a high potential damage of pioneer trees which are growing naturally along rivers. Mostly, local occurring fast growing tree species penetrated the road layer structure. In a few cases other tree species where as well responsible for road structure damages. The age respectively the size of the trees didn't seem to influence significantly the occurrence of asphalt damages. Road structure damages were found to appear unaffected by hydrologic or topographic conditions. However, results have to be interpreted with care as the investigations represent a temporally limited view of the problem situation. The investigations of the root growth characteristics proved that tree roots penetrate the road structure mostly between the gravel sublayer and the asphalt layer as the layers it selves don't allow a penetration because of their high compaction. Furthermore roots appear to be attracted by condensed water at the underside of the asphalt layer. Further steps of the research project imply testing of different

  3. Genetic damage caused by methyl-parathion in mouse spermatozoa is related to oxidative stress

    International Nuclear Information System (INIS)

    Pina-Guzman, B.; Solis-Heredia, M.J.; Rojas-Garcia, A.E.; Uriostegui-Acosta, M.; Quintanilla-Vega, B.

    2006-01-01

    Organophosphorous (OP) pesticides are considered genotoxic mainly to somatic cells, but results are not conclusive. Few studies have reported OP alterations on sperm chromatin and DNA, and oxidative stress has been related to their toxicity. Sperm cells are very sensitive to oxidative damage which has been associated with reproductive dysfunctions. We evaluated the effects of methyl-parathion (Me-Pa; a widely used OP) on sperm DNA, exploring the sensitive stage(s) of spermatogenesis and the relationship with oxidative stress. Male mice (10-12-weeks old) were administered Me-Pa (3-20 mg/kg bw/i.p.) and euthanized at 7- or 28-days post-treatment. Mature spermatozoa were obtained and evaluated for chromatin structure through SCSA (Sperm Chromatin Structure Assay; DNA Fragmentation Index parameters: Mean DFI and DFI%) and chromomycin-A 3 (CMA 3 )-staining, for DNA damage through in situ-nick translation (NT-positive) and for oxidative stress through lipid peroxidation (LPO; malondialdehyde production). At 7-days post-treatment (mature spermatozoa when Me-Pa exposure), dose-dependent alterations in chromatin structure (Mean DFI and CMA 3 -staining) were observed, as well as increased DNA damage, from 2-5-fold in DFI% and NT-positive cells. Chromatin alterations and DNA damage were also observed at 28-days post-treatment (cells at meiosis at the time of exposure); suggesting that the damage induced in spermatocytes was not repaired. Positive correlations were observed between LPO and sperm DNA-related parameters. These data suggest that oxidative stress is related to Me-Pa alterations on sperm DNA integrity and cells at meiosis (28-days post-treatment) and epididymal maturation (7-days post-treatment) are Me-Pa targets. These findings suggest a potential risk of Me-Pa to the offspring after transmission

  4. Maternal health: There is cause for optimism | Burton | South African ...

    African Journals Online (AJOL)

    Maternal health: There is cause for optimism. R Burton. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.7196/SAMJ.7237 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for ...

  5. CORRELATION AMONG DAMAGES CAUSED BY YELLOW BEETLE, CLIMATOLOGICAL ELEMENTS AND PRODUCTION OF GUAVA ACCESSES GROWN IN ORGANIC SYSTEM

    Directory of Open Access Journals (Sweden)

    JULIANA ALTAFIN GALLI

    Full Text Available ABSTRACT The objective of this research was evaluate the damage caused by the yellow beetle on 85 guava accessions and correlations of the damage with the climatological elements and the production of fruit in an orchard of guava conducted in organic system. Ten leaves by access were analyzed containing the injury of insect attack. Each leaf had its foliar area measured by leaf area meter and, after obtaining the total area, the leaf was covered with duct tape, and measure again. The averages were compared by Scott-Knott test at 5% probability. The 15 accessions with highest average damage had the data submitted to the correlation with the minimum and maximum temperature, precipitation and relative humidity. The production was obtained by the number of fruits/plant. The damages are negatively correlated with the mean relative humidity of 7:00h (local time in the period of 14 days prior to the assessments, and negatively affect production. The accessions Saito, L4P16, Monte Alto Comum 1 and L5P19 are promising in organic agriculture, for presenting good production and minor damage to insect attack, when compared to others.

  6. Structural Health Monitoring for Impact Damage in Composite Structures.

    Energy Technology Data Exchange (ETDEWEB)

    Roach, Dennis P.; Raymond Bond (Purdue); Doug Adams (Purdue)

    2014-08-01

    Composite structures are increasing in prevalence throughout the aerospace, wind, defense, and transportation industries, but the many advantages of these materials come with unique challenges, particularly in inspecting and repairing these structures. Because composites of- ten undergo sub-surface damage mechanisms which compromise the structure without a clear visual indication, inspection of these components is critical to safely deploying composite re- placements to traditionally metallic structures. Impact damage to composites presents one of the most signi fi cant challenges because the area which is vulnerable to impact damage is generally large and sometimes very dif fi cult to access. This work seeks to further evolve iden- ti fi cation technology by developing a system which can detect the impact load location and magnitude in real time, while giving an assessment of the con fi dence in that estimate. Fur- thermore, we identify ways by which impact damage could be more effectively identi fi ed by leveraging impact load identi fi cation information to better characterize damage. The impact load identi fi cation algorithm was applied to a commercial scale wind turbine blade, and results show the capability to detect impact magnitude and location using a single accelerometer, re- gardless of sensor location. A technique for better evaluating the uncertainty of the impact estimates was developed by quantifying how well the impact force estimate meets the assump- tions underlying the force estimation technique. This uncertainty quanti fi cation technique was found to reduce the 95% con fi dence interval by more than a factor of two for impact force estimates showing the least uncertainty, and widening the 95% con fi dence interval by a fac- tor of two for the most uncertain force estimates, avoiding the possibility of understating the uncertainty associated with these estimates. Linear vibration based damage detection tech- niques were investigated in the

  7. Compensation for damage to workers health exposed to ionizing radiation in Argentina

    International Nuclear Information System (INIS)

    Sobehart, Leonardo J.

    2003-01-01

    The objective of this report is to analyze the possibility to establish a scheme to compensate damage to workers health exposed to ionizing radiation in Argentina for those cases in which it is possible to assume that the exposure to ionizing radiation is the cause of the cancer suffered by the worker. The proposed scheme is based on the recommendations set out in the 'International Conference on Occupational Radiation Protection: Protecting Workers against Exposure to Ionization Radiation, held in Geneva, Switzerland, August 26-30, 2002. To this end, the study analyzes the present state of scientific knowledge on cancer causation due to genotoxic factors, and the accepted form of the doses-response curve, for the human beings exposure to ionization radiation at low doses with low doses rates. Finally, the labor laws and regulations related to damage compensation; in particular the present Argentine Labor Law; the National Russian Federal Occupational Radiological Health Impairment and Workmen Compensation, the United Kingdom Compensation Scheme for Radiation-linked Diseases and the United States Energy Employees Occupational Illness Compensation Program are described. (author)

  8. Structures of masonry walls in buildings of permanent ruin – causes of damage and methods of repairs

    OpenAIRE

    Bartosz Szostak

    2017-01-01

    Currently there is a lot of castles classified as objects of the permanent ruin. In according to conservation doctrine, it is needed to protect this objects and prevent further degradation. Usually one of the most destructed element in this type of object is masonry wall. In this article has been described selected types of the masonry walls of the permanent ruin, causes of their damages and repairs methods.

  9. Structures of masonry walls in buildings of permanent ruin – causes of damage and methods of repairs

    Directory of Open Access Journals (Sweden)

    Bartosz Szostak

    2017-12-01

    Full Text Available Currently there is a lot of castles classified as objects of the permanent ruin. In according to conservation doctrine, it is needed to protect this objects and prevent further degradation. Usually one of the most destructed element in this type of object is masonry wall. In this article has been described selected types of the masonry walls of the permanent ruin, causes of their damages and repairs methods.

  10. Nur77 forms novel nuclear structures upon DNA damage that cause transcriptional arrest

    International Nuclear Information System (INIS)

    Leseleuc, Louis de; Denis, Francois

    2006-01-01

    The orphan nuclear receptor Nur77 has been implicated in both growth and apoptosis, and its function and activity can be modulated by cellular redistribution. Green fluorescent protein-tagged Nur77 was used to evaluate the role of Nur77 intracellular redistribution in response to genotoxic stress. Selected DNA damaging agents and transcription inhibition lead to rapid redistribution of Nur77 into nuclear structures distinct from conventional nuclear bodies. These nuclear bodies formed transiently were tightly bound to the nuclear matrix and conditions that lead to their appearance were associated with Nur77 transcriptional inhibition. The formation of Nur77 nuclear bodies might be involved in programmed cell death modulation upon exposure to DNA damaging agents that inhibit transcription by sequestrating this proapoptotic factor in dense nuclear structures

  11. The enigma of multiple sclerosis: inflammation and neurodegeneration cause heterogeneous dysfunction and damage

    DEFF Research Database (Denmark)

    Owens, Trevor

    2003-01-01

    progression correlate with axonal damage, and that brain atrophy resulting from axonal loss is a feature of early multiple sclerosis, and is not restricted to the secondary progressive forms of the disease. Inflammatory mediators (CD8 T cells and antibodies) are implicated in axonal damage, and treatment...... cells for oligodendrocytes. SUMMARY: Oligodendrocyte precursors are abundant in multiple sclerosis lesions, but fail to remyelinate. Oligodendrocyte growth and regeneration are probably compromised by the action of growth inhibitory signals and lack of growth stimuli. Inflammatory cells and mediators......PURPOSE OF REVIEW: The demyelinating disease multiple sclerosis has an autoimmune inflammatory component, which has dominated the description of multiple sclerosis. A degenerative component to multiple sclerosis was always apparent, but was underappreciated until recently. Recent work has brought...

  12. Numerical studies for the analysis of damage caused by gas explosions

    International Nuclear Information System (INIS)

    Rischbieter, F.; Horneff, W.; Michelmann, K.; Schaepermeier, E.

    1981-08-01

    Within the framework of the establishment of an immediate safety programme for the Nuclear Process Heat Project, analyses and data available from former explosion accidents are to be reviewed for the derivation of information to be included in the safety concept for the nuclear process heat system. This system is characterised by a close linkage, both in terms of function and spatial arrangement, of the explosive process unit and the nuclear unit of the process heat system. The study in hand deals with the numerical investigation of the deflagrational damage analysis. It is arranged into two parts: (1) Analysis of selected aspects of the explosion accident at Flixborough by means of comparative assessment of various scenarios. (2) Computer-aided calculation of the characteristics of damage to window panes as one of very common structural elements of accident analyses. (orig./DG) [de

  13. Undressing "health fashion": an examination of health-cause clothing and accessories.

    Science.gov (United States)

    Walker, Kandi L; Hart, Joy L; Gregg, Jennifer L; LaJoie, A Scott

    2010-09-01

    Today, fashion items such as rubber wristbands in various colors, pink ribbons, and red dresses represent different health-related causes and can be seen frequently across demographic groups. Complete with pithy slogans (e.g., "Go Red for Women"), these items are part of a larger "health fashion" trend--one that involves wearing, using, and displaying health-cause clothing and accessories. In this article, the authors explore recent interest in "health fashion," examining in particular its origins, effectiveness, and implications.

  14. Upper urinary tract damage caused by ketamine snorting—A report of nine cases

    OpenAIRE

    Hsiang-Ying Lee; Yu-Chao Hsu; Chao-Yu Hsu; Eric Chieh-Lung Chou; Ching-Chia Li; Yung-Shun Juan; Mei-Yu Jang

    2015-01-01

    Objective: The toxicity of ketamine to genitourinary system not only involved in lower urinary tract, which include urinary frequency, urgency, suprapubic pain, dysuria and hematuria, but also upper urinary tracts. However, the reports of ketmaine-induced upper urinary tract damage were rare. Materials and methods: Herein, we reported nine ketamine abusers presented with moderate flank pain with hydronephrosis and lower urinary tract symptoms from three medical centers located around Taiwa...

  15. Individual vs. overarching protection for minimizing the expected damage caused by an attack

    International Nuclear Information System (INIS)

    Levitin, Gregory; Hausken, Kjell; Dai, Yuanshun

    2013-01-01

    The article considers a system consisting of identical elements which can be protected and attacked individually and collectively. The system is aimed at supplying a demand. If, following the attack, the cumulative performance of the elements becomes less than the demand the damage proportional to the unsupplied demand is inflicted. Additional damage is associated with the destruction of the equipment. To destroy any system element the attacker always must penetrate/destroy the collective (overarching) protection. Both the attacker and the defender have limited resources and can distribute them freely between the two types of attack and protection. The attacker chooses the resource distribution and the number of attacked elements to maximize the expected damage associated with equipment losses and unsupplied demand. The defender chooses the resource distribution and the number of protected elements to minimize the system destruction probability. The bi-contest minmax game is formulated and its solutions are presented and analyzed. The influence of the game parameters on the optimal defense and attack strategies is discussed

  16. Spectroellipsometric detection of silicon substrate damage caused by radiofrequency sputtering of niobium oxide

    Science.gov (United States)

    Lohner, Tivadar; Serényi, Miklós; Szilágyi, Edit; Zolnai, Zsolt; Czigány, Zsolt; Khánh, Nguyen Quoc; Petrik, Péter; Fried, Miklós

    2017-11-01

    Substrate surface damage induced by deposition of metal atoms by radiofrequency (rf) sputtering or ion beam sputtering onto single-crystalline silicon (c-Si) surface has been characterized earlier by electrical measurements. The question arises whether it is possible to characterize surface damage using spectroscopic ellipsometry (SE). In our experiments niobium oxide layers were deposited by rf sputtering on c-Si substrates in gas mixture of oxygen and argon. Multiple angle of incidence spectroscopic ellipsometry measurements were performed, a four-layer optical model (surface roughness layer, niobium oxide layer, native silicon oxide layer and ion implantation-amorphized silicon [i-a-Si] layer on a c-Si substrate) was created in order to evaluate the spectra. The evaluations yielded thicknesses of several nm for the i-a-Si layer. Better agreement could be achieved between the measured and the generated spectra by inserting a mixed layer (with components of c-Si and i-a-Si applying the effective medium approximation) between the silicon oxide layer and the c-Si substrate. High depth resolution Rutherford backscattering (RBS) measurements were performed to investigate the interface disorder between the deposited niobium oxide layer and the c-Si substrate. Atomic resolution cross-sectional transmission electron microscopy investigation was applied to visualize the details of the damaged subsurface region of the substrate.

  17. Experience with fuel damage caused by abnormal conditions in handling and transporting operations

    International Nuclear Information System (INIS)

    Bailey, W.J.

    1983-01-01

    Pacific Northwest Laboratory (PNL) conducted a study to determine the expected condition of spent USA light-water reactor (LWR) fuel upon arrival at interim storage or fuel reprocessing facilities or, if fuel is declared a waste, at disposal facilities. Initial findings were described in an earlier PNL paper at PATRAM '80 and in a report. Updated findings are described in this paper, which includes an evaluation of information obtained from the literature and a compilation of cases of known or suspected damage to fuel as a result of handling and/or transporting operations. To date, PNL has evaluated 123 actual cases (98 USA and 25 non-USA). Irradiated fuel was involved in all but 10 of the cases. From this study, it is calculated that the frequency of unusual occurrences involving fuel damage from handling and transporting operations has been low. The damage that did occur was generally minor. The current base of experience with fuel handling and transporting operations indicates that nearly all of these unusual occurrences had only a minor or negligible effect on spent fuel storage facility operations

  18. Population Growth and Damage Caused by Rhopalosiphum padi (L.) (Hemiptera, Aphididae) on Different Cultivars and Phenological Stages of Wheat.

    Science.gov (United States)

    Savaris, M; Lampert, S; Salvadori, J R; Lau, D; Pereira, P R V S; Smaniotto, M A

    2013-10-01

    Among the aphids associated with wheat and other winter cereals, Rhopalosiphum padi (L.) is currently the predominant species in the wheat growing region of southern Brazil. The damage caused by this aphid occurs by direct feeding and/or by the transmission of pathogenic viruses, such as the Barley/Cereal yellow dwarf virus. In order to estimate the direct damage caused by R. padi on wheat, we evaluated the population growth of this aphid during the tillering and elongation stages and its effects on grain yield components. The experiment was conducted in a screenhouse with three wheat cultivars (BRS Guabiju, BRS Timbaúva, and Embrapa 16). The effect of a period of 16 days, starting from an infestation of 40 aviruliferous aphids/plant, was evaluated and compared to non-infested plants. In both stages, the population growth of R. padi was lower on the BRS Timbaúva. Although infestation caused a reduction in the grain yield of the three cultivars, this effect was lower for BRS Timbaúva. The cultivar Embrapa 16 supported higher infestations and was more tolerant to damage than the BRS Guabiju.

  19. Power, Politics, and Health: A New Public Health Practice Targeting the Root Causes of Health Equity.

    Science.gov (United States)

    Iton, Anthony; Shrimali, Bina Patel

    2016-08-01

    Purpose Understanding the WHY, WHAT, and HOW of place-based work in maternal and child health (MCH) is critical to examining the components of the environment that shape health opportunity through the relationship between life expectancy and neighborhood residence. Description On September 18, 2014, during the CityMatCH Leadership and MCH Epidemiology Conference, Dr. Anthony Iton provided the Keynote Address focused on the root causes of health inequities. Assessment The address focused on issues of equity in California and initiatives designed to mitigate and prevent disparities, including the Bay Area Regional Health Equities Initiative framework. Dr. Iton presented information on how the framework translated into investment strategies and a policy and systems change approach to place-based work. Conclusion The field of MCH, because of its focus on supporting health during critical periods of development, is poised to play a significant role in reducing health inequities. Recognizing that human health suffers when low income communities are passive, disenfranchised and disorganized, in order to change this status quo, understanding that human capital is the greatest asset is the urgent challenge to the field of MCH.

  20. Dentinal temperature transients caused by exposure to CO2 laser irradiation and possible pulpal damage.

    Science.gov (United States)

    Jeffrey, I W; Lawrenson, B; Saunders, E M; Longbottom, C

    1990-02-01

    An investigation is described that attempts to establish, in vitro, the characteristics of heat transference following laser irradiation of bovine dentinal tissue and the relationship with the periodicity of radiation. The results of this study appear to indicate that at depths of overlying dentine of up to 3 mm, laser-induced thermal injury to the pulp is a definite possibility. Fail-safe facilities to prevent build up of heat must be incorporated into the design of dental lasers to allow their beneficial effects to be utilized without the risk of iatrogenic damage.

  1. Surgical intervention for complications caused by late radiation damage of the small bowel; a retrospective analysis

    International Nuclear Information System (INIS)

    Halteren, H.K. van; Gortzak, E.; Taal, B.G.; Helmerhorst, Th.J.M.; Aleman, B.M.P.; Hart, A.A.M.; Zoetmulder, F.A.N.

    1993-01-01

    The authors studied the records of 46 patients who had been operated on between 1974 and 1990 in the Netherlands Cancer Institute because of complications due to late radiation damage of the small bowel. The following factors led to an increase in complication-risk: hypalbuminemia. more than one laparotomy prior to irradiation and a short interval (< 12 months) between irradiation and surgical intervention. The following factors related to a poorer survival: incomplete resection of the primary tumor and a short interval (< 12 months) between irradiation and surgical intervention. The type f surgical intervention did not have cumulative prognostic value in relation to complication-risk or survival. (author)

  2. Change in the dibenzyldimethylammonium accumulation by irradiated Streptococcus cells caused by radiation damage modifiers

    International Nuclear Information System (INIS)

    Fomenko, B.S.; Leont'eva, G.A.

    1975-01-01

    Anoxia, concentrated cell suspension, glutathione (10 -4 -10 -2 M) or low concentrations of cysteine (10 -4 -10 -3 M) exerted a radioprotective effect and suppressed the accumulation of dibenzyldimethylammonium chloride (DDA + ) by γ-irradiated (40 krad) S. faecalis cells. Dilution of the cell suspensions and higher cysteine concentrations (>10 -3 M) increased the effects of irradiation on bacterial accumulation of DDA + and decreased the cell survival. The lethal action of irradiation apparently involves damage to the mechanisms which maintain a normal membrane potential

  3. Optimal choice: assessing the probability of additional damage to buildings caused by water level changes of larger areas

    Science.gov (United States)

    Bijnagte, J. L.; Luger, D.

    2012-12-01

    In the Northern parts of the Netherlands exploration of natural gas reservoirs causes subsidence over large areas. As a consequence, the water levels in canals and polders have to be adjusted over time in order to keep the groundwater levels at a constant depth relative to the surface level. In the middle of the subsidence area it is relatively easy to follow the settlements by a uniform lowering of the water level. This would however result in a relative lowering of the groundwater table at the edges of the subsidence area. Given the presence of soft compressible soils, this would result in induced settlements. For buildings in these areas this will increase the chance of damage. A major design challenge lies therefore in the optimisation of the use of compartments. The more compartments the higher the cost therefore the aim is to make compartments in the water management system that are as large as possible without causing inadmissible damage to buildings. In order to asses expected damage from different use of compartments three tools are needed. The first is a generally accepted method of damage determination, the second a method to determine the contribution to damage of a new influence, e.g. a groundwater table change. Third, and perhaps most importantly, a method is needed to evaluate effects not for single buildings but for larger areas. The first need is covered by established damage criteria like those of Burland & Wroth or Boscardin & Cording. Up until now the second and the third have been problematic. This paper presents a method which enables to assign a contribution to the probability of damage of various recognised mechanisms such as soil and foundation inhomogeneity, uneven loading, ground water level changes. Shallow subsidence due to peat oxidation and deep subsidence due to reservoir depletion can be combined. In order to address the third issue: evaluation of effects for larger areas, the method uses a probabilistic approach. Apart from a

  4. Unexpected ICD pulse generator failure due to electronic circuit damage caused by electrical overstress.

    Science.gov (United States)

    Hauser, R G; Hayes, D L; Almquist, A K; Epstein, A E; Parsonnet, V; Tyers, G F; Vlay, S C; Schoenfeld, M H

    2001-07-01

    Because it is a lifesaving device, the unexpected failure of an ICD can be catastrophic. We report ICD electronic circuit failure due to electrical overstress damage (EOS) to the high voltage hybird circuit and other electronic components in a series of ICD pulse generator models. Data were obtained from the Multicenter Registry of Pacemaker and ICD Pacemaker and Lead Failures, and from the manufactures' adverse event reports, that were in the FDA's Manufacturer and User Facility Device Experience (MAUDE) database. Of 16 nonbattery Guidant/CPI ICD pulse generator failures reported to the registry, 6 (38%) have been confirmed by the manufacturer to be EOS related, and Guidant/CPI has reported 273 such failures to the FDA as of 12/29/00. The signs of failure included loss of telemetry and inability to deliver therapy, and some patients have experienced serious adverse events. Hybrid circuit damage may have occurred during capacitor charging or reform, and the majority appears to have happened during normal ICD function. While the incidence of this problem is unknown, a management strategy should be adopted that includes routine follow-up every 3 months and device evaluation after a shock or exposure to external defibrillation or electrosurgical devices. This study suggests that additional data are needed to determine the incidence of this problem, and that our present methods for monitoring the performance of ICD's following market release are inadequate.

  5. Mild hyperthermia can induce adaptation to cytogenetic damage caused by subsequent X irradiation

    International Nuclear Information System (INIS)

    Cai, Lu.; Jiang, Jie.

    1995-01-01

    Many low-level environmental agents are able to induce an increased resistance to subsequent mutagenic effects induced by ionizing radiation. In this paper, an induced cytogenetic adaptation to radiation in human lymphocytes was studied with mild hyperthermia as the adaptive treatment and compared with that induced by low-dose radiation. We found that this adaptation could be induced not only in PHA-stimulated human lymphocytes (at 14, 38 and 42 h after addition of PHA), but also in unstimulated G 0 -phase cells (before addition of PHA) by mild hyperthermia (41 degrees C for 1 h) as well as 50 mGy X rays. When the two adaptive treatments were combined, no additive effects on the magnitude of the adaptation induced were observed, suggesting that low-dose radiation and hyperthermia may share one mechanism of induction of adaptation to cytogenetic damage. Some mechanisms which may be involved in the induction of adaptation to cytogenetic damage by low-dose radiation are discussed and compared with the effects of mild hyperthermia in inducing thermotolerance and radioresistance. 56 refs., 4 figs., 3 tabs

  6. Silicon surface damage caused by reactive ion etching in fluorocarbon gas mixtures containing hydrogen

    International Nuclear Information System (INIS)

    Norstroem, H.; Blom, H.; Ostling, M.; Nylandsted Larsen, A.; Keinonen, J.; Berg, S.

    1991-01-01

    For selective etching of SiO 2 on silicon, gases or gas mixtures containing hydrogen are often used. Hydrogen from the glow discharge promotes the formation of a thin film polymer layer responsible for the selectivity of the etching process. The reactive ion etch (RIE) process is known to create damage in the silicon substrate. The influence of hydrogen on the damage and deactivation of dopants is investigated in the present work. The distribution of hydrogen in silicon, after different etching and annealing conditions have been studied. The influence of the RIE process on the charge carrier concentration in silicon has been investigated. Various analytical techniques like contact resistivity measurements, four point probe measurements, and Hall measurements have been used to determine the influence of the RIE process on the electrical properties of processed silicon wafers. The hydrogen profile in as-etched and post annealed wafers was determined by the 1 H( 15 N,αγ) 12 C nuclear reaction. The depth of the deactivated surface layer is discussed in terms of the impinging hydrogen ion energy, i.e., the possibility of H + ions to pick up an energy equal to the peak-to-peak voltage of the rf signal

  7. Elevated Plasma Cardiac Troponin T Levels Caused by Skeletal Muscle Damage in Pompe Disease.

    Science.gov (United States)

    Wens, Stephan C A; Schaaf, Gerben J; Michels, Michelle; Kruijshaar, Michelle E; van Gestel, Tom J M; In 't Groen, Stijn; Pijnenburg, Joon; Dekkers, Dick H W; Demmers, Jeroen A A; Verdijk, Lex B; Brusse, Esther; van Schaik, Ron H N; van der Ploeg, Ans T; van Doorn, Pieter A; Pijnappel, W W M Pim

    2016-02-01

    Elevated plasma cardiac troponin T (cTnT) levels in patients with neuromuscular disorders may erroneously lead to the diagnosis of acute myocardial infarction or myocardial injury. In 122 patients with Pompe disease, the relationship between cTnT, cardiac troponin I, creatine kinase (CK), CK-myocardial band levels, and skeletal muscle damage was assessed. ECG and echocardiography were used to evaluate possible cardiac disease. Patients were divided into classic infantile, childhood-onset, and adult-onset patients. cTnT levels were elevated in 82% of patients (median 27 ng/L, normal values normal in all patients, whereas CK-myocardial band levels were increased in 59% of patients. cTnT levels correlated with CK levels in all 3 subgroups (Pmass index measured with echocardiography was normal in all the 3 subgroups. cTnT mRNA expression in skeletal muscle was not detectable in controls but was strongly induced in patients with Pompe disease. cTnT protein was identified by mass spectrometry in patient-derived skeletal muscle tissue. Elevated plasma cTnT levels in patients with Pompe disease are associated with skeletal muscle damage, rather than acute myocardial injury. Increased cTnT levels in Pompe disease and likely other neuromuscular disorders should be interpreted with caution to avoid unnecessary cardiac interventions. © 2016 American Heart Association, Inc.

  8. Liver damage caused by hepatitis C viral infection and ethyl alcohol consumption

    Directory of Open Access Journals (Sweden)

    Kostić Velimir

    2006-01-01

    Full Text Available Background/Aim. Hepatitis C virus infection (HCV is a complex disease, most commonly chronicle (80-85%. The aim of this research was to determinate the level of the liver damage in the patients cansed by HCV in conjunction with consuming ethyl alcohol. Methods. The research included 15 patients with chronic HCV infection supported by the misuse of ethyl alcohol, as well. The diagnosis of C infection hepatitis was proved using the ELISA test and PCR method. Results. The results of the study showed the liver damage by both HCV infection and ethyl alcohol, which was verified by the presence of biochemical changes and patohystological processing of the patients (liver biopsy and prosection. Patohystological changes were at the level of liver cirrhosis and carcinoma (2 patients. There was a signficant difference between the two subgroups (p < 0.001 regarding the examined values γ-GT, PLT and PTV. The basic therapeutic procedure was to introduce this category of patients into alcohol abstinence, and, in a few patients, to apply the antivirus therapy, as well. Conclusion. Based on the number of the examined patients (n = 15, we could conclude that a prolonged ethyl alcohol misuse with the presence of HCV infection was in a correlation with the liver disease progression.

  9. Actinic skin damage and mortality--the First National Health and Nutrition Examination Survey Epidemiologic Follow-up Study.

    Directory of Open Access Journals (Sweden)

    Wei He

    Full Text Available BACKGROUND: Exposure to sunlight may decrease the risk of several diseases through the synthesis of vitamin D, whereas solar radiation is the main cause of some skin and eye diseases. However, to the best of our knowledge, the association of sun-induced skin damage with mortality remains unknown. METHODOLOGY/PRINCIPAL FINDINGS: Subjects were 8472 white participants aged 25-74 years in the First National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. Cardiovascular disease mortality, cancer mortality, and all-cause mortality were obtained by either a death certificate or a proxy interview, or both. Actinic skin damage was examined and recorded by the presence and severity (absent, minimal, moderate, or severe of overall actinic skin damage and its components (i.e., fine telangiectasia, solar elastosis, and actinic keratoses. Cox regression and Kaplan-Meier methods were applied to explore the associations. A total of 672 cancer deaths, 1500 cardiovascular disease deaths, and 2969 deaths from all causes were documented through the follow-up between 1971 and 1992. After controlling for potential confounding variables, severe overall actinic skin damage was associated with a 45% higher risk for all-cause mortality (95% CI: 1.22, 1.72; P<0.001, moderate overall skin damage with a 20% higher risk (95% CI: 1.08., 1.32; P<0.001, and minimal overall skin damage with no significant mortality difference, when compared to those with no skin damage. Similar results were obtained for all-cause mortality with fine telangiectasia, solar elastosis, and actinic keratoses. The results were similar for cancer and cardiovascular disease mortality. CONCLUSIONS: The present study gives an indication of an association of actinic skin damage with cardiovascular disease, cancer and all-cause mortality in white subjects. Given the lack of support in the scientific literature and potential unmeasured confounding factors, this finding should be

  10. Characterization of microdose damage caused by single heavy ion observed in trench type power MOSFETs

    International Nuclear Information System (INIS)

    Ikeda, Naomi; Kuboyama, Satoshi; Maru, Akifumi; Tamura, Takashi; Hirao, Toshio; Abe, Hiroshi

    2010-01-01

    It was demonstrated that anomalously large degradation observed in power MOSFETs was caused by a single heavy ion. It was identified as a microdose effect and successfully characterized by several parameters extracted from experimental data. (author)

  11. World Health Organization cardiovascular risk stratification and target organ damage.

    Science.gov (United States)

    Piskorz, D; Bongarzoni, L; Citta, L; Citta, N; Citta, P; Keller, L; Mata, L; Tommasi, A

    2016-01-01

    Prediction charts allow treatment to be targeted according to simple markers of cardiovascular risk; many algorithms do not recommend screening asymptomatic target organ damage which could change dramatically the assessment. To demonstrate that target organ damage is present in low cardiovascular risk hypertensive patients and it is more frequent and severe as global cardiovascular risk increases. Consecutive hypertensive patients treated at a single Latin American center. Cardiovascular risk stratified according to 2013 WHO/ISH risk prediction chart America B. Left ventricular mass assessed by Devereux method, left ventricular hypertrophy considered >95g/m(2) in women and >115g/m(2) in men. Transmitral diastolic peak early flow velocity to average septal/lateral peak early diastolic relaxation velocity (E/e' ratio) measured cut off value >13. Systolic function assessed by tissue Doppler average interventricular septum/lateral wall mitral annulus rate systolic excursion (s wave). A total of 292 patients were included of whom 159 patients (54.5%) had cardiovascular risk of 20%. Left ventricular hypertrophy was detected in 17.6% low risk patients, 27.8% in medium risk and 23.3% in high risk (p<0.05), abnormal E/e' ratio was found in 13.8%, 31.1% and 27.9%, respectively (p<0.05). Mean s wave was 8.03+8, 8.1+9 and 8.7+1cm/s for low, intermediate and high risk patients, respectively (p<0.025). Target organ damage is more frequent and severe in high risk; one over four subjects was misclassified due to the presence of asymptomatic target organ damage. Copyright © 2015 SEHLELHA. Published by Elsevier España, S.L.U. All rights reserved.

  12. Intensity of diffracted X-rays from biomolecules with radiation damage caused by strong X-ray pulses

    International Nuclear Information System (INIS)

    Kai, Takeshi; Tokuhisa, Atsushi; Moribayashi, Kengo; Fukuda, Yuji; Kono, Hidetoshi; Go, Nobuhiro

    2014-01-01

    In order to realize the coherent X-ray diffractive imaging of single biomolecules, the diffraction intensities, per effective pixel of a single biomolecule with radiation damage, caused by irradiation using a strong coherent X-ray pulse, were examined. A parameter survey was carried out for various experimental conditions, using a developed simulation program that considers the effect of electric field ionization, which was slightly reported on in previous studies. The two simple relationships among the parameters were identified as follows: (1) the diffraction intensity of a biomolecule slightly increases with the incident X-ray energy; and that (2) the diffraction intensity is approximately proportional to the target radius, when the radius is longer than 400 Å, since the upper limit of the incident intensity for damage to the biomolecules marginally changes with respect to the target radius. (author)

  13. Genotoxic Evaluation of Mikania laevigata Extract on DNA Damage Caused by Acute Coal Dust Exposure

    Energy Technology Data Exchange (ETDEWEB)

    Freitas, T.P.; Heuser, V.D.; Tavares, P.; Leffa, D.D.; da Silva, G.A.; Citadini-Zanette, V.; Romao, P.R.T.; Pinho, R.A.; Streck, E.L.; Andrade,V.M. [University of Extremo Catarinense, Criciuma, SC (Brazil)

    2009-06-15

    We report data on the possible antigenotoxic activity of Mikania laevigata extract (MLE) after acute intratracheal instillation of coal dust using the comet assay in peripheral blood, bone marrow, and liver cells and the micronucleus test in peripheral blood of Wistar rats. The animals were pretreated for 2 weeks with saline solution (groups 1 and 2) or MLE (100 mg/kg) (groups 3 and 4). On day 15, the animals were anesthetized with ketamine (80 mg/kg) and xylazine (20 mg/kg), and gross mineral coal dust (3 mg/0.3 mL saline) (groups 2 and 4) or saline solution (0.3 mL) (groups 1 and 3) was administered directly in the lung by intratracheal administration. Fifteen days after coal dust or saline instillation, the animals were sacrificed, and the femur, liver, and peripheral blood were removed. The results showed a general increase in the DNA damage values at 8 hours for all treatment groups, probably related to surgical procedures that had stressed the animals. Also, liver cells from rats treated with coal dust, pretreated or not with MLE, showed statistically higher comet assay values compared to the control group at 14 days after exposure. These results could be expected because the liver metabolizes a variety of organic compounds to more polar by-products. On the other hand, the micronucleus assay results did not show significant differences among groups. Therefore, our data do not support the antimutagenic activity of M. laevigata as a modulator of DNA damage after acute coal dust instillation.

  14. Displacement damage caused by gamma-rays and neutrons on Au and Se.

    Energy Technology Data Exchange (ETDEWEB)

    Doyle, Barney Lee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-11-01

    This report documents theoretical calculations of displacement damage produced by gamma rays and neutrons on various materials. The average energy of the gamma rays was 1.24 MeV and 1.0 MeV for the neutrons. The fluence of the gamma rays was 1.2e14 γ/cm2 , for the neutrons it was 1.0e12 n/cm2. The initial materials of interest were Au and Se. The total doses of the gamma ray exposures were in the 100 kRad range for both elements. An equivalent electron fluence was approximated to be the same as the gamma ray fluence over one gamma ray attenuation length in both materials and at the same 1.24 MeV energy. The maximum recoil energy of the Au and Se for these electrons was calculated relativisticaly to be 29 and 72 eV respectively. The relativisitic McKinley and Feshbach theory for the atomic recoil cross sections produced by the electrons were in the 10s of mbarn range and an upper limit for the concentration of Frenkel pairs for the gamma ray exposures for both elements was in the ppb range. The Robinson Energy Partioning Theory for non-ionizing energy loss (NIEL) of ions in solids was used to calculate the concentration of Frenkel pairs produced by the 1 MeV neutrons, and this concentration was also in the ppb range for both Au and Se. Low damage levels like this can have effects on minority carrier recombination in semiconductors, but are not expected to have any effect on metals like Au, or metalloids such as Se.

  15. DNA damage and apoptosis of endometrial cells cause loss of the early embryo in mice exposed to carbon disulfide

    International Nuclear Information System (INIS)

    Zhang, Bingzhen; Shen, Chunzi; Yang, Liu; Li, Chunhui; Yi, Anji; Wang, Zhiping

    2013-01-01

    Carbon disulfide (CS 2 ) may lead to spontaneous abortion and very early pregnancy loss in women exposed in the workplace, but the mechanism remains unclear. We designed an animal model in which gestating Kunming strain mice were exposed to CS 2 via i.p. on gestational day 4 (GD4). We found that the number of implanted blastocysts on GD8 was significantly reduced by each dose of 0.1 LD 50 (157.85 mg/kg), 0.2 LD 50 (315.7 mg/kg) and 0.4 LD 50 (631.4 mg/kg). In addition, both the level of DNA damage and apoptosis rates of endometrial cells on GD4.5 were increased, showed definite dose–response relationships, and inversely related to the number of implanted blastocysts. The expressions of mRNA and protein for the Bax and caspase-3 genes in the uterine tissues on GD4.5 were up-regulated, while the expressions of mRNA and protein for the Bcl-2 gene were dose-dependently down-regulated. Our results indicated that DNA damage and apoptosis of endometrial cells were important reasons for the loss of implanted blastocysts induced by CS 2 . - Highlights: • We built an animal model of CS2 exposure during blastocyst implantation. • Endometrial cells were used in the comet assay to detect DNA damage. • CS2 exposure caused DNA damage and endometrial cell apoptosis. • DNA damage and endometrial cell apoptosis were responsible for embryo loss

  16. DNA damage and apoptosis of endometrial cells cause loss of the early embryo in mice exposed to carbon disulfide

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Bingzhen [Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan (China); Shen, Chunzi [Centers for Disease Control and Prevention, Zibo (China); Yang, Liu; Li, Chunhui; Yi, Anji [Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan (China); Wang, Zhiping, E-mail: zhipingw@sdu.edu.cn [Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan (China)

    2013-12-01

    Carbon disulfide (CS{sub 2}) may lead to spontaneous abortion and very early pregnancy loss in women exposed in the workplace, but the mechanism remains unclear. We designed an animal model in which gestating Kunming strain mice were exposed to CS{sub 2} via i.p. on gestational day 4 (GD4). We found that the number of implanted blastocysts on GD8 was significantly reduced by each dose of 0.1 LD{sub 50} (157.85 mg/kg), 0.2 LD{sub 50} (315.7 mg/kg) and 0.4 LD{sub 50} (631.4 mg/kg). In addition, both the level of DNA damage and apoptosis rates of endometrial cells on GD4.5 were increased, showed definite dose–response relationships, and inversely related to the number of implanted blastocysts. The expressions of mRNA and protein for the Bax and caspase-3 genes in the uterine tissues on GD4.5 were up-regulated, while the expressions of mRNA and protein for the Bcl-2 gene were dose-dependently down-regulated. Our results indicated that DNA damage and apoptosis of endometrial cells were important reasons for the loss of implanted blastocysts induced by CS{sub 2}. - Highlights: • We built an animal model of CS2 exposure during blastocyst implantation. • Endometrial cells were used in the comet assay to detect DNA damage. • CS2 exposure caused DNA damage and endometrial cell apoptosis. • DNA damage and endometrial cell apoptosis were responsible for embryo loss.

  17. Lactoferrin and lactoferrin chimera inhibit damage caused by enteropathogenic Escherichia coli in HEp-2 cells

    NARCIS (Netherlands)

    Flores-Villaseñor, H.; Canizalez-Román, A.; de la Garza, M.; Nazmi, K.; Bolscher, J.G.M.; Leon-Sicairos, N.

    2012-01-01

    Enteropathogenic Escherichia coli (EPEC) is an important cause of infant diarrhea in developing countries. It produces a characteristic intestinal histopathological lesion on enterocytes known as ‘attaching and effacing’ (A/E), and these two steps are mediated by a type-III secretory system. In the

  18. Strain-Based Damage Determination Using Finite Element Analysis for Structural Health Management

    Science.gov (United States)

    Hochhalter, Jacob D.; Krishnamurthy, Thiagaraja; Aguilo, Miguel A.

    2016-01-01

    A damage determination method is presented that relies on in-service strain sensor measurements. The method employs a gradient-based optimization procedure combined with the finite element method for solution to the forward problem. It is demonstrated that strains, measured at a limited number of sensors, can be used to accurately determine the location, size, and orientation of damage. Numerical examples are presented to demonstrate the general procedure. This work is motivated by the need to provide structural health management systems with a real-time damage characterization. The damage cases investigated herein are characteristic of point-source damage, which can attain critical size during flight. The procedure described can be used to provide prognosis tools with the current damage configuration.

  19. Inequity and health. Is malnutrition really caused by poor nutrition?

    Science.gov (United States)

    Bharmal, F Y

    2000-08-01

    To look at inequities leading to malnutrition and from the wider picture to find root causes and deal with them in order to alleviate malnutrition. Literature review. The health of the population is adversely affected by the inequities in the country. Women and children being most vulnerable are worst affected. The prevalence of Protein Energy Malnutrition (P.E.M.) in children under five years of age is 51 percent. Such a magnitude of malnutrition in a country, where availability of food per capita is more than adequate, points towards the fact that the inequities within the country are at the root of the problem. Poor income is not the only predictor of malnutrition, gender, urban-rural differences in access, utilization and quality of health care also influence health. In addition, there are some underlying factors such as illiteracy, unawareness of the mother about healthy behaviors, lack of decision-making power of women, along with deep-rooted cultural values of a patriarchal system. Malnutrition is caused by a multitude of factors, some of which are biological, others are environmental, cultural or social. Education of the invisible half of the population, who actually look after the children and the family, is an important strategy to alleviate this problem.

  20. Water pollution causes ultrastructural and functional damages in Pellia neesiana (Gottsche) Limpr.

    Science.gov (United States)

    Basile, Adriana; Sorbo, Sergio; Lentini, Marco; Conte, Barbara; Esposito, Sergio

    2017-09-01

    The aim of this work is to evaluate the effects of freshwater pollution in the heavily contaminated Sarno River (Campania, South Italy), using Pellia neesiana (Pelliaceae Metzgeriales) in order to propose this liverwort as a potential bioindicator, able to record the effects of water pollution, particularly the one related to metal (loid) contamination. Samples of P. neesiana in nylon bags were disposed floating for one week on the waters of Sarno River in three sites characterised by an increasing pollution. As control, some specimens were cultured in vitro in Cd- and Pb-added media, at the same pollutants' levels as measured in the most polluted site. P. neesiana cell ultrastructure was modified and severe alterations were observed in chloroplasts from samples exposed in the most polluted site, and Cd- and Pb-cultured samples. Concurrently, a strong increase in the occurrence of Heat shock proteins 70 (HSP70) was detected in gametophytes following the pollution gradient. In conclusion, ultrastructural damages can be directly related to HSP 70 occurrence in liverwort tissues, and proportional to the degree of pollution present in the river; thus our study suggests P. neesiana as an affordable bioindicator of freshwaters pollution. Copyright © 2016 Elsevier GmbH. All rights reserved.

  1. Does the phycotoxin Okadaic acid cause oxidative stress damages and histological alterations to seabream (Sparus aurata)?

    Science.gov (United States)

    Souid, Ghada; Souayed, Nouha; Haouas, Zohra; Maaroufi, Khira

    2018-03-15

    Okadaic Acid (OA) is a marine toxin responsible for DSP (Diarrheic Shellfish Poisoning) in humans produced by dinoflagellate. The genotoxic and cytotoxic effects of OA have been well reported in mammalian experimental animals and in vitro cultured cells. However, there are no available investigations regarding the involvement of the oxidative stress pathways in OA toxicity, especially on aquatic animals such as fish. In this context, we aimed in the present work to demonstrate whether OA (7.5 μg/ml) induces oxidative stress and histopathological damages in the fish species Sparus aurata under short term exposure (2 h, 4 h and 24 h). To this end, we have assessed lipid peroxidation and anti-oxidative stress response in liver tissue, and finally ultrastructural changes were investigated in hepatic and gills tissues. Our results clearly showed that OA induced significant enhancement in all tested parameters in a time dependent manner and seems to be a strong inducer of oxidative stress in aquatic animals. The data of the present study indicate also that histology is a successful tool to reveal OA impact on liver and gill tissues of Sparus aurata since the animal showed vascular dilation and hepatocellular membrane disintegration in liver and hypertrophy in secondary lamellae and necrotic aspect in the primary lamellae in gill tissue. Copyright © 2018 Elsevier Ltd. All rights reserved.

  2. Histological evaluation of brain damage caused by crude quinolizidine alkaloid extracts from lupines.

    Science.gov (United States)

    Bañuelos Pineda, J; Nolasco Rodríguez, G; Monteon, J A; García López, P M; Ruiz Lopez, M A; García Estrada, J

    2005-10-01

    The effects of the intracerebroventricular (ICV) administration of crude extracts of lupin quinolizidine alkaloids (LQAs) were studied in adult rat brain tissue. Mature L. exaltatus and L. montanus seeds were collected in western Mexico, and the LQAs from these seeds were extracted and analyzed by capillary gas chromatography. This LQA extract was administered to the right lateral ventricle of adult rats through a stainless steel cannula on five consecutive days. While control animals received 10 microl of sesame oil daily (vehicle), the experimental rats (10 per group) received 20 ng of LQA from either L. exaltatus or from L. montanus. All the animals were sacrificed 40 h after receiving the last dose of alkaloids, and their brains were removed, fixed and coronal paraffin sections were stained with haematoxylin and eosin. Immediately after the administration of LQA the animals began grooming and suffered tachycardia, tachypnea, piloerection, tail erection, muscular contractions, loss of equilibrium, excitation, and unsteady walk. In the brains of the animals treated with LQA damaged neurons were identified. The most frequent abnormalities observed in this brain tissue were "red neurons" with shrunken eosinophilic cytoplasm, strongly stained pyknotic nuclei, neuronal swelling, spongiform neuropil, "ghost cells" (hypochromasia), and abundant neuronophagic figures in numerous brain areas. While some alterations in neurons were observed in control tissues, unlike those found in the animals treated with LQA these were not significant. Thus, the histopathological changes observed can be principally attributed to the administration of sparteine and lupanine present in the alkaloid extracts.

  3. Compensation for oil pollution damage caused by oil spills from ships and the International Oil Pollution Compensation Fund

    International Nuclear Information System (INIS)

    Jacobsson, M.

    1994-01-01

    Liability and compensation for pollution damage caused by oil spills from laden tankers is governed by two international conventions: the 1969 Civil Liability Convention and the 1971 Fund Convention. The Civil Liability Convention established a system of strict liability for tanker owners and introduced compulsory liability insurance. The Fund Convention created a system of supplementary compensation administered by an intergovernmental organization, the International Oil Pollution Compensation Fund (IOPC Fund), which at present has 56 member states (August 1993). The IOPC Fund pays compensation to victims of oil pollution in member states when the compensation from the ship owner and his insurer is insufficient. (author)

  4. The causes of skin damage and leg ulceration in chronic venous disease.

    Science.gov (United States)

    Smith, Philip Coleridge

    2006-09-01

    Chronic venous disease with skin changes of the leg is a common condition affecting up to 1 in 20 people in westernized countries. The causes of this problem are not fully understood, although research in recent years has revealed a number of important mechanisms that contribute to the disease process. Patients with chronic venous disease suffer persistently raised pressures in their deep and superficial veins in the lower limb. Leucocytes become "trapped" in the circulation of the leg during periods of venous hyper-tension produced by sitting or standing. Studies of the plasma levels of neutrophil granule enzymes shows that these are increased during periods of venous hypertension, suggesting that this causes activation of the neutrophils. Investigation of the leucocyte surface ligands CD11b and CD62L shows that the more activated neutrophils and monocytes are sequestered during venous hypertension. Measurement of plasma levels of the soluble parts of the endothelial adhesion molecules VCAM, ICAM, and ELAM show that these are all elevated in patients with chronic venous disease compared to controls. Following 30 minutes of venous hypertension produced by standing, these levels are further increased. These data suggest that venous hypertension causes neutrophil and monocyte activation, which in turn causes injury to the endothelium. Chronic injury to the endothelium leads to a chronic inflammatory condition of the skin that we know clinically as lipodermatosclerosis. This is mediated by perivascular inflammatory cells, principally macrophages, in the skin microcirculation. These stimulate fibroblasts in the skin leading to tissue remodeling and laying down of fibrous tissue. Vascular endothelial growth factor stimulates proliferation of capillaries within the skin. Skin in this state has the potential to ulcerate in response to minor injury.

  5. UV-B component of sunlight causes measurable damage in field-grown maize (Zea mays L.): developmental and cellular heterogeneity of damage and repair

    International Nuclear Information System (INIS)

    Stapleton, A.E.; Thornber, C.S.; Walbot, V.

    1997-01-01

    Ultraviolet radiation has diverse morphogenetic and damaging effects on plants. The end point of damage is reduced plant growth, but in the short term UV radiation damages specific cellular components. We measured cyclobutane pyrimidine dimers in maize DNA from plants grown in natural solar radiation. Green maize tissues had detectable DNA damage, roots had less damage, and anthers had much more damage than green leaves. This heterogeneity in damage levels may reflect differences in dose received or in damage repair. The architecture of green tissues had no measurable effects on DNA damage levels, as leaf sheath and leaf blade were equivalent. We observed a slight increase in damage levels in plants sampled at the end of the day, but there was no accumulation of damage over the growing season. We measured photoreactivation, and found substantial levels of this light-dependent repair in both the epidermis and inner cell layers of leaves, and in all organelles that contain DNA – the nucleus, chloroplasts and mitochondria. We conclude that maize has efficient mechanisms for photo repair of daily UV-induced DNA damage that prevent accumulation

  6. Interface Control Document for the EMPACT Module that Estimates Electric Power Transmission System Response to EMP-Caused Damage

    Energy Technology Data Exchange (ETDEWEB)

    Werley, Kenneth Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Mccown, Andrew William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)ory

    2016-06-26

    The EPREP code is designed to evaluate the effects of an Electro-Magnetic Pulse (EMP) on the electric power transmission system. The EPREP code embodies an umbrella framework that allows a user to set up analysis conditions and to examine analysis results. The code links to three major physics/engineering modules. The first module describes the EM wave in space and time. The second module evaluates the damage caused by the wave on specific electric power (EP) transmission system components. The third module evaluates the consequence of the damaged network on its (reduced) ability to provide electric power to meet demand. This third module is the focus of the present paper. The EMPACT code serves as the third module. The EMPACT name denotes EMP effects on Alternating Current Transmission systems. The EMPACT algorithms compute electric power transmission network flow solutions under severely damaged network conditions. Initial solutions are often characterized by unacceptible network conditions including line overloads and bad voltages. The EMPACT code contains algorithms to adjust optimally network parameters to eliminate network problems while minimizing outages. System adjustments include automatically adjusting control equipment (generator V control, variable transformers, and variable shunts), as well as non-automatic control of generator power settings and minimal load shedding. The goal is to evaluate the minimal loss of customer load under equilibrium (steady-state) conditions during peak demand.

  7. Dynamical tendencies of health consequences caused by competitive risk factors

    International Nuclear Information System (INIS)

    Bykov, A.A.; Pronina, I.A.; Kudriavtsev, G.I.

    2000-01-01

    The paper deals with the generalized probabilistic approach for analyzing health consequences caused by various exposure factors. Formally basing on the competitive risk theory, it is introduced a general risk model for analysis the influence of environmental risk factors to human health. The usefulness of the model approach is in the opportunity of taking into account: time delay of impact and consequence manifestation; easy comparisons of exposure factors with different nature and various consequences (morbidity and mortality, carcinogenic and genetic); social and environmental components in overall mortality. Preliminary examples of comparative risk analysis are demonstrated on the Russian demography and environmental data with the attempt of characterizing the dynamical tendencies and evolution of introduced risk index. The prospects of the probabilistic approach and the results obtaining on this basis are discussed. (author)

  8. Dietary choline during periadolescence attenuates cognitive damage caused by neonatal maternal separation in male rats.

    Science.gov (United States)

    Moreno Gudiño, Hayarelis; Carías Picón, Diamela; de Brugada Sauras, Isabel

    2017-07-01

    Choline (Ch) is an essential nutrient that acts as a cognitive facilitator when administered during perinatal periods, and it has been recognised as a 'pharmacological' agent that can ease cognitive dysfunctions provoked by exposure to damaging stimuli during early developmental stages. The aim of the present work is to determine whether providing a diet rich in Ch would reduce the severity of the memory deficit provoked by a neonatal stress episode in male adult rats. The effect of Ch on memory was measured using memory tasks such as object and place recognition. Ontogenetic manipulations were conducted during two sensitive developmental periods. During the first post-natal (PN) 14 days, only the male rat pups were selected and half of them were separated from the mother, group maternal separation (MS). Subsequently, during periadolescence (PN 21-60), the rats were exposed to a deficient (DEF = 0 g/kg Ch chloride), sufficient (CON = 1.1 g/kg Ch chloride), or supplemented (SUP = 5 g/kg Ch chloride) diets for this nutrient. The results indicated that for group MS, only rats fed with the SUP diet were able to recognise the familiar object and place that had been experienced 24 hours before, unlike groups DEF and CON. In addition, whereas rats in the non-separated group (No-MS) recognised the object independently of the diet, only rats that received a DEF diet failed to recognise the place, showing that a Ch deficit affects spatial memory tasks. These results show that Ch supplementation during periadolescence can attenuate the memory deficit provoked by extended neonatal stress.

  9. Environmental enrichment may protect against neural and behavioural damage caused by withdrawal from chronic alcohol intake.

    Science.gov (United States)

    Nobre, Manoel Jorge

    2016-12-01

    Exposure to stress and prolonged exposure to alcohol leads to neuronal damages in several brain regions, being the medial prefrontal cortex (mPFC) one of the most affected. These changes presumably reduce the ability of the organism to cope with these stimuli and may underlie a series of maladaptive behaviours among which include drug addiction and withdrawal. Drug-addicted individuals show a pattern of behavior similar to patients with lesions of the mPFC. This impairment in the decision-making could be one of the mechanisms responsible for the transition from the casual to compulsive drug use. The environmental enrichment (EE) has a protective effect on the neural and cognitive impairments induced by psychoactive drugs, including ethyl alcohol. The present study aims to determine the influence of withdrawal from intermittent long-term alcohol exposure on alcohol preference, emotional reactivity and neural aspects of early isolated or grouped reared rats kept under standard or complex environments and the influence of social isolation on these measures, as well. Our results point out new insights on this matter showing that the EE can attenuate the adverse effects of withdrawal and social isolation on rat's behavior. This effect is probably due to its protective action on the mPFC integrity, including the cingulate area 1 (Cg1), and the prelimbic (PrL) and infralimbic cortex (IL), what could account for the absence of changes in the emotional reactivity in EE alcohol withdrawal rats. We argue that morphological changes at these cortical levels can afford the emotional, cognitive and behavioural dysregulations verified following withdrawal from chronic alcohol intake. Copyright © 2016 ISDN. Published by Elsevier Ltd. All rights reserved.

  10. Protective effect of Xingnaojia formulation on rats with brain and liver damage caused by chronic alcoholism.

    Science.gov (United States)

    Li, Shuang; Wang, S U; Guo, Zhi-Gang; Huang, Ning; Zhao, Fan-Rong; Zhu, Mo-Li; Ma, Li-Juan; Liang, Jin-Ying; Zhang, Yu-Lin; Huang, Zhong-Lin; Wan, Guang-Rui

    2015-11-01

    The aim of this study was to observe the effect of a formulation of traditional Chinese medicine extracts known as Xingnaojia (XNJ) on the liver function, learning ability and memory of rats with chronic alcoholism and to verify the mechanism by which it protects the brain and liver. A rat model of chronic alcoholism was used in the study. The spatial learning ability and memory of the rats were tested. The rats were then sacrificed and their brains and hepatic tissues were isolated. The activity of superoxide dismutase (SOD) and levels of glutamate (Glu), N-methyl D-aspartate receptor subtype 2B (NR2B), cyclin-dependent kinase 5 (CDK5) and cannabinoid receptor 1 (CB1) in the hippocampus were analyzed. The ultrastructure of the hepatic tissue was observed by electron microscopy. In addition, the activities of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in serum were tested and the levels of low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG) and total cholesterol (TCHOL) were analyzed. XNJ enhanced the learning and memory of rats with chronic alcoholism. Treatment with XNJ increased the activity of SOD, and decreased the expression levels of NR2B mRNA and NR2B, CB1 and CDK5 proteins in the brain tissues compared with those in the model rats. It also increased the activity of ALDH in the serum and liver, decreased the serum levels of LDL, TG and TCHOL and increased the serum level of HDL. These results indicate that XNJ exhibited a protective effect against brain and liver damage in rats with chronic alcoholism.

  11. A comparison of penetration and damage caused by different types of arrowheads on loose and tight fit clothing.

    Science.gov (United States)

    MacPhee, Nichole; Savage, Anne; Noton, Nikolas; Beattie, Eilidh; Milne, Louise; Fraser, Joanna

    2018-03-01

    Bows and arrows are used more for recreation, sport and hunting in the Western world and tend not to be as popular a weapon as firearms or knives. Yet there are still injuries and fatalities caused by these low-velocity weapons due to their availability to the public and that a licence is not required to own them. This study aimed to highlight the penetration capabilities of aluminium arrows into soft tissue and bones in the presence of clothing. Further from that, how the type and fit of clothing as well as arrowhead type contribute to penetration capacity. In this study ballistic gelatine blocks (non-clothed and loose fit or tight fit clothed) were shot using a 24lb weight draw recurve bow and aluminium arrows accompanied by four different arrowheads (bullet, judo, blunt and broadhead). The penetration capability of aluminium arrows was examined, and the depth of penetration was found to be dependent on the type of arrowhead used as well as by the type and fit or lack thereof of the clothing covering the block. Loose fit clothing reduced penetration with half of the samples, reducing penetration capacity by percentages between 0% and 98.33%, at a range of 10m. While the remaining half of the samples covered with tight clothing led to reductions in penetration of between 14.06% and 94.12%. The damage to the clothing and the gelatine (puncturing, cutting and tearing) was affected by the shape of the arrowhead, with the least damaged caused by the blunt arrowheads and the most by the broadhead arrows. Clothing fibres were also at times found within the projectile tract within the gelatine showing potential for subsequent infection of an individual with an arrow wound. Ribs, femur bones and spinal columns encased in some of the gelatine blocks all showed varying levels of damage, with the most and obvious damage being exhibited by the ribs and spinal column. The information gleaned from the damage to clothing, gelatine blocks and bones could potentially be useful for

  12. Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells.

    Directory of Open Access Journals (Sweden)

    Jesper A B Strickertsson

    Full Text Available BACKGROUND: Achlorhydria caused by e.g. atrophic gastritis allows for bacterial overgrowth, which induces chronic inflammation and damage to the mucosal cells of infected individuals driving gastric malignancies and cancer. Enterococcus faecalis (E. faecalis can colonize achlohydric stomachs and we therefore wanted to study the impact of E. faecalis infection on inflammatory response, reactive oxygen species (ROS formation, mitochondrial respiration, and mitochondrial genetic stability in gastric mucosal cells. METHODS: To separate the changes induced by bacteria from those of the inflammatory cells we established an in vitro E. faecalis infection model system using the gastric carcinoma cell line MKN74. Total ROS and superoxide was measured by fluorescence microscopy. Cellular oxygen consumption was characterized non-invasively using XF24 microplate based respirometry. Gene expression was examined by microarray, and response pathways were identified by Gene Set Analysis (GSA. Selected gene transcripts were verified by quantitative real-time polymerase chain reaction (qRT-PCR. Mitochondrial mutations were determined by sequencing. RESULTS: Infection of MKN74 cells with E. faecalis induced intracellular ROS production through a pathway independent of oxidative phosphorylation (oxphos. Furthermore, E. faecalis infection induced mitochondrial DNA instability. Following infection, genes coding for inflammatory response proteins were transcriptionally up-regulated while DNA damage repair and cell cycle control genes were down-regulated. Cell growth slowed down when infected with viable E. faecalis and responded in a dose dependent manner to E. faecalis lysate. CONCLUSIONS: Infection by E. faecalis induced an oxphos-independent intracellular ROS response and damaged the mitochondrial genome in gastric cell culture. Finally the bacteria induced an NF-κB inflammatory response as well as impaired DNA damage response and cell cycle control gene

  13. Aluminium-induced excessive ROS causes cellular damage and metabolic shifts in black gram Vigna mungo (L.) Hepper.

    Science.gov (United States)

    Chowra, Umakanta; Yanase, Emiko; Koyama, Hiroyuki; Panda, Sanjib Kumar

    2017-01-01

    Aluminium-induced oxidative damage caused by excessive ROS production was evaluated in black gram pulse crop. Black gram plants were treated with different aluminium (Al 3+ ) concentrations (10, 50 and 100 μM with pH 4.7) and further the effects of Al 3+ were characterised by means of root growth inhibition, histochemical assay, ROS content analysis, protein carbonylation quantification and 1 H-NMR analysis. The results showed that aluminium induces excessive ROS production which leads to cellular damage, root injury, stunt root growth and other metabolic shifts. In black gram, Al 3+ induces cellular damage at the earliest stage of stress which was characterised from histochemical analysis. From this study, it was observed that prolonged stress can activate certain aluminium detoxification defence mechanism. Probably excessive ROS triggers such defence mechanism in black gram. Al 3+ can induce excessive ROS initially in the root region then transported to other parts of the plant. As much as the Al 3+ concentration increases, the rate of cellular injury and ROS production also increases. But after 72 h of stress, plants showed a lowered ROS level and cellular damage which indicates the upregulation of defensive mechanisms. Metabolic shift analysis also showed that the black gram plant under stress has less metabolic content after 24 h of treatment, but gradually, it was increased after 72 h of treatment. It was assumed that ROS played the most important role as a signalling molecule for aluminium stress in black gram.

  14. Safety assessment of the potential for foreign object - caused fretting - wear damages on PWR steam generator U-tubes

    International Nuclear Information System (INIS)

    Jo, Jong Chull; Jhung, Myung Jo; Kim, Woong Sik; Kim, Hho Jung

    2003-01-01

    This study investigates the safety assessment of the potential for fretting-wear damages on Steam Generator (SG) U-tubes caused by foreign object in operating nuclear power plants. The operating SG shell-side flow field conditions are obtained from three-dimensional SG flow calculation using the ATHOS3 code. Modal analyses are performed for the finite element modelings of U-tubes to get the natural frequency, corresponding mode shape and participation factor. The wear rate of U-tube caused by foreign object is calculated using the Archard formula and the remaining life of the tube is predicted. Also, discussed in this study are the effects of flow velocity, internal pressure, tube-to-foreign object contact angle, and vibration of the tube on the remaining life of the tube

  15. Management of anterior teeth damage caused by complex caries through aesthetic endorestoration

    Directory of Open Access Journals (Sweden)

    Nanik Zubaidah

    2011-03-01

    Full Text Available Background: Dental caries is a microbiological disease that result in localized dissolution and destruction of the calcified tissue. It is multifactorial, therefore prevention must be based on a multifactorial approach. The damage of anterior teeth due to complex caries, for certain person may interfere their performance and decrease their self confidence aesthetically. Restoration of tooth form and function, especially on anterior teeth is highly valuable. Purpose: To present a case of maxillary anterior teeth with complex caries, through endorestoration treatment for recovering its original function and aesthetic. Case: The 21 years old male patient with complex carries on maxillary anterior teeth number 12, 11, 21, 22 and 23. The patient felt bad about his performance and affect his self confidence. The patient visited the clinic to repair his teeth and to get its form and function aesthetically. Case management: The endorestoration treatment was performed for carious teeth through pulpectomy followed by insertion of post retention and porcelain fused to metal crowns. Conclusion: Anterior teeth with severed complex caries can be managed through endorestoration treatment to recover its performance and function aesthetically.Latar belakang: Dental karies adalah penyakit infeksi yang berakibat kerusakan jaringan kalsifikasi dan bersifat multifactorial. Oleh karena itu pencegahan dilakukan dengan pendekatan multifactorial. Kerusakan gigi anterior karena karies kompleks untuk orang-orang tertentu mungkin berdampak pada penampilan dan penurunan kepercayaan diri karena factor estetik. Perbaikan gigi anterior dari berbagai kerusakan baik dalam hal bentuk maupun fungsinya sangat besar nilainya. Tujuan: Untuk menunjukkan kasus gigi anterior rahang atas karena karies kompleks melalui perawatan endorestorasi untuk mengembalikan fungsi gigi asli dan estetik. Kasus: Laki-laki usia 21 tahun dengan karies kompleks pada gigi anterior rahang atas 12, 11, 21

  16. Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice.

    Directory of Open Access Journals (Sweden)

    Masashi Fujihara

    2008-09-01

    Full Text Available The purpose of this study was to determine whether mice exposed to chronic cigarette smoke develop features of early age-related macular degeneration (AMD. Two month old C57Bl6 mice were exposed to either filtered air or cigarette smoke in a smoking chamber for 5 h/day, 5 days/week for 6 months. Eyes were fixed in 2.5% glutaraldehyde/2% paraformaldehyde and examined for ultrastructural changes by transmission electron microscopy. The contralateral eye was fixed in 2% paraformaldehyde and examined for oxidative injury to the retinal pigmented epithelium (RPE by 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OHdG immunolabeling and apoptosis by TUNEL labeling. Mice exposed to cigarette smoke had immunolabeling for 8-OHdG in 85+/-3.7% of RPE cells counted compared to 9.5+/-3.9% in controls (p<0.00001. Bruch membrane was thicker in mice exposed to smoke (1086+/-332 nm than those raised in air (543+/-132 nm; p = 0.0069. The two most pronounced ultrastructural changes (severity grading scale from 0-3 seen were a loss of basal infoldings (mean difference in grade = 1.98; p<0.0001, and an increase in intracellular vacuoles (mean difference in grade = 1.7; p<0.0001. Ultrastructural changes to Bruch membrane in cigarette-smoke exposed mice were smaller in magnitude but consistently demonstrated significantly higher grade injury in cigarette-exposed mice, including basal laminar deposits (mean difference in grade = 0.54; p<0.0001, increased outer collagenous layer deposits (mean difference in grade = 0.59; p = 0.002, and increased basal laminar deposit continuity (mean difference in grade = 0.4; p<0.0001. TUNEL assay showed a higher percentage of apoptotic RPE from mice exposed to cigarette smoke (average 8.0+/-1.1% than room air (average 0+/-0%; p = 0.043. Mice exposed to chronic cigarette smoke develop evidence of oxidative damage with ultrastructural degeneration to the RPE and Bruch membrane, and RPE cell apoptosis. This model could be useful for studying the

  17. Assessment of the economic costs of damage caused by air pollution

    International Nuclear Information System (INIS)

    Holland, M.R.

    1995-01-01

    Cost-benefit analysis is one of the fundamental tools for the development of economic instruments for pollution control. The costs of various abatement measures are reasonably well characterised. However, assessment of the economic costs of pollutant impacts is less well developed. This paper reports on two studies carried out for DGXII of the European Commission, the ExternE-Project and the Green Accounting Research Project. Both studies have been performed by international, multi-disciplinary research teams. Analysis of the effects of emissions of PM 10 , SO 2 , NO x and VOCs (as ozone precursors) has included assessment of human health, materials, crops and other terrestrial ecosystems, and freshwater fisheries. The analysis follows the 'impact pathway' approach, linking dose-response functions, valuation data and other models. It differs significantly to earlier 'top-down' approaches that made only very limited use of the wealth of scientific data available. Most success has been achieved in analysis of impacts on human health, building materials and crops. Significant uncertainties exist for these receptors, though these have been identified and are now being addressed. Assessment of impacts on other receptors, perhaps most notably forests, is more limited. The methodology is particularly applicable for analysis of impacts on receptors for which the critical loads approach is not appropriate. 7 refs., 3 figs., 1 tab

  18. An assessment of environmental damage caused by NATO bombing of NIS Jugopetrol facilities

    International Nuclear Information System (INIS)

    Milosevic, D.; Radu, A.; Novakovic, J.

    2002-01-01

    This paper present our investigation of the effects of NATO bombing of the Jugopetrol facilities in Serbia during the Spring of 1999. Concentrations of hazardous material in air, water and soil have been measured and compared to the situation before the bombing. Only partial results are presented in this paper. High concentrations of hydrocarbons were detected in the air immediately after the bombing and the destruction of installations, due to burning and evaporation of oil derivatives. A great amount of spilled mineral oils has been detected in water and soil near the destroyed installations. We have detected a noticeable increase in pollution after the NATO bombing. In addition to above mentioned pollution, the destruction of large parts of waste treatment system within the Jugopetrol's installations caused severe environmental problems. The recovery of the destroyed installation and waste treatment systems require considerable amount of money and time, and cannot be accomplished without the help of foreign investment. (author)

  19. Feeding behavior and crop damage caused by capybaras (Hydrochoerus hydrochaeris) in an agricultural landscape.

    Science.gov (United States)

    Felix, G A; Almeida Paz, I C L; Piovezan, U; Garcia, R G; Lima, K A O; Nääs, I A; Salgado, D D; Pilecco, M; Belloni, M

    2014-11-01

    This study aimed to assess the yield loss caused by capybaras in rural areas of Dourados-MS, their feeding periods, crop preferences and the landscape characteristics of farms that may affect the occurrence of capybara's herds. Semi-structured interviews in 24 different farms were done during a period between April 2010 and August 2011. Field observations were held at different times of the day, and also during the night in order to record peaks of the feeding behavior in six farms. Direct counting of capybaras along with the group of animals reported as seen by the farmers during the interviews was used to estimate the size of herds. Data was analyzed using the Principal Components Analyses and the Analytic Hierarchy Process. The average number of capybaras found in a regular herd was 18.8 ± 7.90 animals. The average number of capybara herd by farms was of 1.38 ± 0.92 while the average number of capybaras by farms was 32.33 ± 27.87. Capybaras selected rice (Oryza sativa) when it was available (14.5% of devastation in 1.18% of total planted area); however, the most eaten crop was corn (Zea mays) with 38.55% of loss rate in 16.17% of the total planted area. Capybaras ate mostly in the evening and during the night. The availability of water resources in the rural area predisposed the occurrence of capybara's herds.

  20. Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise.

    Science.gov (United States)

    Miner, Jonathan J; Cao, Bin; Govero, Jennifer; Smith, Amber M; Fernandez, Estefania; Cabrera, Omar H; Garber, Charise; Noll, Michelle; Klein, Robyn S; Noguchi, Kevin K; Mysorekar, Indira U; Diamond, Michael S

    2016-05-19

    Zika virus (ZIKV) infection in pregnant women causes intrauterine growth restriction, spontaneous abortion, and microcephaly. Here, we describe two mouse models of placental and fetal disease associated with in utero transmission of ZIKV. Female mice lacking type I interferon signaling (Ifnar1(-/-)) crossed to wild-type (WT) males produced heterozygous fetuses resembling the immune status of human fetuses. Maternal inoculation at embryonic day 6.5 (E6.5) or E7.5 resulted in fetal demise that was associated with ZIKV infection of the placenta and fetal brain. We identified ZIKV within trophoblasts of the maternal and fetal placenta, consistent with a trans-placental infection route. Antibody blockade of Ifnar1 signaling in WT pregnant mice enhanced ZIKV trans-placental infection although it did not result in fetal death. These models will facilitate the study of ZIKV pathogenesis, in utero transmission, and testing of therapies and vaccines to prevent congenital malformations. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. The effects of low-level laser on muscle damage caused by Bothrops neuwiedi venom

    Directory of Open Access Journals (Sweden)

    DM Dourado

    2008-01-01

    Full Text Available The present study aimed to assess the effects of low-level laser (660 nm on myonecrosis caused by the insertion of Bothrops neuwiedi venom in the gastrocnemius muscle of rats. Male Wistar rats were divided into three groups (n = 24 each: Group S (0.9% saline solution; Group V (venom and Group VLLL (venom plus low-level laser. These categories were subdivided into four additional groups (n = 6 based on the euthanasia timing (3 hours, 24 hours, 3 days and 7 days. The groups V and VLLL were inoculated with 100 µL of concentrated venom (40 µg/mL in the gastrocnemius muscle. The muscle was irradiated using a gallium-aluminum-arsenide laser (GaAlAs at 35 mW power and 4 J/cm² energy density for 3 hours, 24 hours, 3 days or 7 days after venom inoculation. To evaluate the myotoxic activity of the venom, CK activity was measured and the muscle was histologically analyzed. The low-level laser reduced venom-induced CK activity in the groups euthanized at 3 hours, 24 hours and 3 days (p < 0.0001. Histological analysis revealed that low-level laser reduced neutrophilic inflammation as well as myofibrillar edema, hemorrhage and myonecrosis following B. neuwiedi envenomation. These results suggest that low-level laser can be useful as an adjunct therapy following B. neuwiedi envenomation.

  2. The effects of low-level laser on muscle damage caused by Bothrops neuwiedi venom

    Energy Technology Data Exchange (ETDEWEB)

    Dourado, D.M.; Matias, R.; Almeida, M.F.; Paula, K.R. de; Carvalho, P.T.C. [University for the Development of the State and of the Region of Pantanal (UNIDERP), Campo Grande, MS (Brazil). Lab. of Experimental Histopathology]. E-mail: ccfi@uniderp.br; Vieira, R.P. [University of Sao Paulo (USP), SP (Brazil). School of Medicine. Dept. of Pathology and Physical Therapy; Oliveira, L.V.F. [Nove de Julho University (UNINOVE), Sao Paulo, SP (Brazil). Masters Program in Rehabilitation Sciences

    2008-07-01

    The present study aimed to assess the effects of low-level laser (660 nm) on myonecrosis caused by the insertion of Bothrops neuwiedi venom in the gastrocnemius muscle of rats. Male Wistar rats were divided into three groups (n = 24 each): Group S (0.9% saline solution); Group V (venom) and Group VLLL (venom plus low-level laser). These categories were subdivided into four additional groups (n = 6) based on the euthanasia timing (3 hours, 24 hours, 3 days and 7 days). The groups V and VLLL were inoculated with 100 {mu}L of concentrated venom (40 {mu}g/mL) in the gastrocnemius muscle. The muscle was irradiated using a gallium-aluminum-arsenide laser (GaAlAs) at 35 mW power and 4 J/cm{sup 2} energy density for 3 hours, 24 hours, 3 days or 7 days after venom inoculation. To evaluate the myotoxic activity of the venom, CK activity was measured and the muscle was histologically analyzed. The low-level laser reduced venom-induced CK activity in the groups euthanized at 3 hours, 24 hours and 3 days (p < 0.0001). Histological analysis revealed that low-level laser reduced neutrophilic inflammation as well as myofibrillar edema, hemorrhage and myonecrosis following B. neuwiedi envenomation. These results suggest that low-level laser can be useful as an adjunct therapy following B. neuwiedi envenomation. (author)

  3. The effects of low-level laser on muscle damage caused by Bothrops neuwiedi venom

    International Nuclear Information System (INIS)

    Dourado, D.M.; Matias, R.; Almeida, M.F.; Paula, K.R. de; Carvalho, P.T.C.; Vieira, R.P.; Oliveira, L.V.F.

    2008-01-01

    The present study aimed to assess the effects of low-level laser (660 nm) on myonecrosis caused by the insertion of Bothrops neuwiedi venom in the gastrocnemius muscle of rats. Male Wistar rats were divided into three groups (n = 24 each): Group S (0.9% saline solution); Group V (venom) and Group VLLL (venom plus low-level laser). These categories were subdivided into four additional groups (n = 6) based on the euthanasia timing (3 hours, 24 hours, 3 days and 7 days). The groups V and VLLL were inoculated with 100 μL of concentrated venom (40 μg/mL) in the gastrocnemius muscle. The muscle was irradiated using a gallium-aluminum-arsenide laser (GaAlAs) at 35 mW power and 4 J/cm 2 energy density for 3 hours, 24 hours, 3 days or 7 days after venom inoculation. To evaluate the myotoxic activity of the venom, CK activity was measured and the muscle was histologically analyzed. The low-level laser reduced venom-induced CK activity in the groups euthanized at 3 hours, 24 hours and 3 days (p < 0.0001). Histological analysis revealed that low-level laser reduced neutrophilic inflammation as well as myofibrillar edema, hemorrhage and myonecrosis following B. neuwiedi envenomation. These results suggest that low-level laser can be useful as an adjunct therapy following B. neuwiedi envenomation. (author)

  4. Damage caused by a nanosecond UV laser on a heated copper surface

    Energy Technology Data Exchange (ETDEWEB)

    Henč-Bartolić, V., E-mail: visnja.henc@fer.hr [University of Zagreb, Faculty of Electrical Engineering and Computing, Unska 3, 10000 Zagreb (Croatia); Bončina, T. [University of Maribor, Faculty of Mechanical Engineering, Smetanova 17, 2000 Maribor (Slovenia); Jakovljević, S., E-mail: suzana.jakovljevic@fsb.hr [University of Zagreb, Faculty of Mechanical Engineering and Naval Architecture, Ivana Lučića 5, 10002 Zagreb (Croatia); Panjan, P. [Jožef Stefan Institute, Jamova 39, 1000 Ljubljana (Slovenia); Zupanič, F. [University of Maribor, Faculty of Mechanical Engineering, Smetanova 17, 2000 Maribor (Slovenia)

    2016-08-15

    Highlights: • A Cu-plate was exposed to nanosecond UV laser with max. energy 1.1 J/cm{sup 2}. • Surface topography was studied on the cold and heated copper plate. • At room temperature, a crater formed, the melt was ejected from it. • Capillary waves formed in the vicinity of the crater at 360 °C. - Abstract: This work studied the effect of thin copper plate temperature on its surface morphology after irradiation using a pulsed nanosecond UV laser. The surface characteristics were investigated using scanning electron microscopy, energy dispersive X-ray spectroscopy, focused ion beam and stylus profilometry. When a target was at room temperature, a crater and the radial flow of molten Cu from the crater was observed. When the thin target was warm (about 360 °C ± 20 °C), a crater was smaller, and quasi-semicircular waves with the periodicity of around 3 μm appeared in its vicinity. The origin of the waves is Marangoni effect, causing thermocapillary waves, which in same occasions had a structure of final states of chaos in Rayleigh–Bénard convection.

  5. To Investigate the Effect of Colchicine in Prevention of Adhesions Caused by Serosal Damage in Rats

    Directory of Open Access Journals (Sweden)

    İhsan Yıldız

    2015-01-01

    Full Text Available Introduction and Aim. Adhesion formation is a process which starts with an inflammation caused by a number of factors and eventually results in fibrosis. Colchicine prevents adhesion formation which is antifibrous process. The effectivity of colchicine in the prevention of adhesions was investigated. Materials and Methods. A total of 36 rats were equally divided into three groups: (I control group 1 (n=12, (II abrasion group 2 (n=12, and (III abrasion + colchicine group 3 (n=12. Group 1 underwent laparotomy and was orally given physiological serum 2 cc/day for 10 days. In Group 2, injury was created in the cecum serosa following laparotomy and they were orally given physiological serum 2 cc/day for 10 days. In Group 3, injury was created in the cecum serosa following laparotomy and the rats were orally given colchicine 50 mcg kg/day mixed with physiological serum 2 cc/day for 10 days. Laparotomy was performed and adhesions were examined both macroscopically and microscopically. Both macroscopic and microscopic examinations were performed using Zühlke’s score. Results. A significant difference was observed among the adhesion scores of the groups both macroscopically and microscopically. Macroscopic score was lower in group 3 than group 2. Microscopic score was lower in group 3 than group 2. Conclusion. Oral administration of colchicine is effective in the prevention of adhesions.

  6. Executive order no. 433 of 24th May 1996. Executive order on the international fund for compensation for damages caused by oil pollution, 1992

    International Nuclear Information System (INIS)

    1996-05-01

    The Danish executive order on the international fund for the compensation for damages caused by oil pollution, 1992 is related to the Danish law no. 205 of March 29th 1996, and is based on the International Convention on the Establishment of an International Fund for Compensation for Oil Damage, 1992. The document includes the convention's protocol presented in French, Danish and English. (AB)

  7. Can Diopatra neapolitana (Annelida: Onuphidae) regenerate body damage caused by bait digging or predation?

    Science.gov (United States)

    Pires, A.; Freitas, R.; Quintino, V.; Rodrigues, A. M.

    2012-09-01

    The regenerative ability of Diopatra neapolitana was evaluated under laboratory conditions following nine experimental amputation levels: before the beginning of the branchiae (chaetiger 3 or 4), in the branchial region, at chaetigers 10, 15, 20, 25, 30, 35 and 40 and after the branchiae, at chaetigers 45-55. Specimens amputated at the 20th chaetiger were not able to regenerate and did not survive. The posterior portion of the specimens amputated up to chaetiger 15, regenerated the anterior part but the anterior ends were unable to survive. The anterior end of the specimens amputated at and beyond the 25th chaetiger regenerated the posterior part but the posterior ends were not able to regenerate an anterior part. Percent survival was directly related to the number of branchial segments left in the regenerating specimen and reached 100% only when the specimens were amputated beyond the branchial region. These results indicate that the species has regenerative ability and should survive the loss of a few anterior chaetigers, namely caused by predation. However, the results also indicate that bait digging could impair the survival of the posterior part remaining in the tube, as usually more than 20 chaetigers are harvested by bait collectors. Regarding field-collected specimens, D. neapolitana was found regenerating a mean of 9.0 ± 2.51 chaetigers, and Diopatra marocensis 7.5 ± 1.93 chaetigers, at the anterior end. The higher percentage of field-collected specimens showing regeneration of the anterior end belonged to D. marocensis. Only very few specimens, for both species, were found regenerating the posterior part of the body.

  8. Dominant Repression by Arabidopsis Transcription Factor MYB44 Causes Oxidative Damage and Hypersensitivity to Abiotic Stress

    Directory of Open Access Journals (Sweden)

    Helene Persak

    2014-02-01

    Full Text Available In any living species, stress adaptation is closely linked with major changes of the gene expression profile. As a substrate protein of the rapidly stress-induced mitogen-activated protein kinase MPK3, Arabidopsis transcription factor MYB44 likely acts at the front line of stress-induced re-programming. We recently characterized MYB44 as phosphorylation-dependent positive regulator of salt stress signaling. Molecular events downstream of MYB44 are largely unknown. Although MYB44 binds to the MBSII element in vitro, it has no discernible effect on MBSII-driven reporter gene expression in plant co-transfection assays. This may suggest limited abundance of a synergistic co-regulator. MYB44 carries a putative transcriptional repression (Ethylene responsive element binding factor-associated Amphiphilic Repression, EAR motif. We employed a dominant repressor strategy to gain insights into MYB44-conferred stress resistance. Overexpression of a MYB44-REP fusion markedly compromised salt and drought stress tolerance—the opposite was seen in MYB44 overexpression lines. MYB44-mediated resistance likely results from induction of tolerance-enhancing, rather than from repression of tolerance-diminishing factors. Salt stress-induced accumulation of destructive reactive oxygen species is efficiently prevented in transgenic MYB44, but accelerated in MYB44-REP lines. Furthermore, heterologous overexpression of MYB44-REP caused tissue collapse in Nicotiana. A mechanistic model of MAPK-MYB-mediated enhancement in the antioxidative capacity and stress tolerance is proposed. Genetic engineering of MYB44 variants with higher trans-activating capacity may be a means to further raise stress resistance in crops.

  9. Damage Detection and Verification System (DDVS) for In-Situ Health Monitoring

    Science.gov (United States)

    Williams, Martha K.; Lewis, Mark; Szafran, J.; Shelton, C.; Ludwig, L.; Gibson, T.; Lane, J.; Trautwein, T.

    2015-01-01

    Project presentation for Game Changing Program Smart Book Release. Detection and Verification System (DDVS) expands the Flat Surface Damage Detection System (FSDDS) sensory panels damage detection capabilities and includes an autonomous inspection capability utilizing cameras and dynamic computer vision algorithms to verify system health. Objectives of this formulation task are to establish the concept of operations, formulate the system requirements for a potential ISS flight experiment, and develop a preliminary design of an autonomous inspection capability system that will be demonstrated as a proof-of-concept ground based damage detection and inspection system.

  10. Damage Detection with Streamlined Structural Health Monitoring Data

    OpenAIRE

    Li, Jian; Deng, Jun; Xie, Weizhi

    2015-01-01

    The huge amounts of sensor data generated by large scale sensor networks in on-line structural health monitoring (SHM) systems often overwhelms the systems’ capacity for data transmission and analysis. This paper presents a new concept for an integrated SHM system in which a streamlined data flow is used as a unifying thread to integrate the individual components of on-line SHM systems. Such an integrated SHM system has a few desirable functionalities including embedded sensor data compressio...

  11. DANOS MECÂNICOS OCASIONADOS POR SISTEMAS DOSADORES DE SEMENTES MECHANICAL DAMAGE CAUSED BY SEED METERING SYSTEMS

    Directory of Open Access Journals (Sweden)

    Paulo Alcanfor Ximenes

    2007-09-01

    Full Text Available

    Avaliaram-se os efeitos de danos mecânicos ocasionados por cinco sistemas dosadores de sementes, em quatro culturas. Amostras das sementes foram coletadas antes e após passarem pelos sistemas dosadores e foram submetidas a testes de pureza, germinação e vigor. Não houve diferença entre os efeitos de danos mecânicos ocasionados pelos sistemas dosadores empregados nas sementes de milho. Para as sementes de feijão, menores efeitos foram verificados quando da utilização dos dosadores pneumático a vácuo e copo dosador. O sistema rotor acanalado causou menores danos às sementes de arroz e os sistemas disco  horizontal perfurado e copo dosador foram os que menos danificaram as sementes de soja. O sistema dosador pneumático a vácuo ocasionou o maior índice de dano mecânico nas sementes de soja.

    PALAVRAS-CHAVE: Semeadoras; distribuidores de sementes; rotor acanalado.

    Effects of mechanical damage caused by five seed metering systems were evaluated in four crops. Seed samples were collected before and after passing through the measuring systems and submitted to tests of purity, germination and vigor. There was no difference in the level of mechanical damage caused by the metering systems used for maize seeds. For common bean seeds, minor effects were verified when using the vacuum metering disk and the feed cup. The fluted feed system showed the best performance for rice seeds, and the horizontal perforated disk and feed cup systems exhibited the best results for soybean seeds. The vacuum metering disk system caused the highest level of mechanical damage to soybean seeds.

    KEY-WORDS: Planter machine; seed distributor; fluted feed.

  12. Diagnostic Error in Correctional Mental Health: Prevalence, Causes, and Consequences.

    Science.gov (United States)

    Martin, Michael S; Hynes, Katie; Hatcher, Simon; Colman, Ian

    2016-04-01

    While they have important implications for inmates and resourcing of correctional institutions, diagnostic errors are rarely discussed in correctional mental health research. This review seeks to estimate the prevalence of diagnostic errors in prisons and jails and explores potential causes and consequences. Diagnostic errors are defined as discrepancies in an inmate's diagnostic status depending on who is responsible for conducting the assessment and/or the methods used. It is estimated that at least 10% to 15% of all inmates may be incorrectly classified in terms of the presence or absence of a mental illness. Inmate characteristics, relationships with staff, and cognitive errors stemming from the use of heuristics when faced with time constraints are discussed as possible sources of error. A policy example of screening for mental illness at intake to prison is used to illustrate when the risk of diagnostic error might be increased and to explore strategies to mitigate this risk. © The Author(s) 2016.

  13. Collective violence caused by climate change and how it threatens health and human rights.

    Science.gov (United States)

    Levy, Barry S; Sidel, Victor W

    2014-06-14

    The weight of scientific evidence indicates that climate change is causally associated with collective violence. This evidence arises from individual studies over wide ranges of time and geographic location, and from two extensive meta-analyses. Complex pathways that underlie this association are not fully understood; however, increased ambient temperatures and extremes of rainfall, with their resultant adverse impacts on the environment and risk factors for violence, appear to play key roles. Collective violence due to climate change poses serious threats to health and human rights, including by causing morbidity and mortality directly and also indirectly by damage to the health-supporting infrastructure of society, forcing people to migrate from their homes and communities, damaging the environment, and diverting human and financial resources. This paper also briefly addresses issues for future research on the relationship between climate change and collective violence, the prevention of collective violence due to climate change, and States' obligations to protect human rights, to prevent collective violence, and to promote and support measures to mitigate and adapt to climate change. Copyright © 2014 Levy and Sidel. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

  14. Enantioselective oxidative stress and oxidative damage caused by Rac- and S-metolachlor to Scenedesmus obliquus.

    Science.gov (United States)

    Liu, Huijun; Xia, YiLu; Cai, Weidan; Zhang, Yina; Zhang, Xiaoqiang; Du, Shaoting

    2017-04-01

    The rational use and environmental security of chiral pesticides has gained the interest of many researchers. The enantioselective effects of Rac- and S-metolachlor on oxidative stress in Scenedesmus obliquus were determined in this study. Stronger green fluorescence was observed in response to S-metolachlor treatment than to Rac-metolachlor treatment, suggesting that more reactive oxygen species (ROS) were stimulated by S-metolachlor. ROS levels following S-metolachlor treatment were 1.92-, 8.31-, and 1.08-times higher than those observed following Rac-metolachlor treatment at 0.1, 0.2, and 0.3 mg/L, respectively. Superoxide dismutase (SOD) and catalase (CAT) were stimulated with increasing herbicide concentrations, with S-metolachlor exhibiting a greater effect. Oxidative damage in terms of chlorophyll (Chl) content, cellular membrane permeability, and cellular ultrastructures of S. obliquus were investigated. Chla and Chlb contents in algae treated with Rac-metolachlor were 2-6-fold higher than those in algae treated with S-metolachlor at 0.1, 0.2, and 0.3 mg/L. The cellular membrane permeability of algae exposed to 0.3 mg/L Rac- and S-metolachlor was 6.19- and 42.5-times that of the control. Correlation analysis implied that ROS are the major factor responsible for the oxidative damage caused by Rac- and S-metolachlor. Damage to the chloroplasts and cell membrane of S. obliquus, low production of starch granules, and an increased number of vacuoles were observed upon ultrastructural morphology analysis by transmission electron microscope. These results indicate that S-metolachlor has a greater effect on S. obliquus than Rac-metolachlor. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. Health effects of fluoride pollution caused by coal burning

    Energy Technology Data Exchange (ETDEWEB)

    Ando, M.; Tadano, M.; Yamamoto, S.; Tamura, K.; Chen, X. [Regional Environment Division, National Institute for Environmental Studies, Tsukuba, 305-0083 Ibaraki (Japan); Asanuma, S. [Japan Institute of Rural Medicine, Usuda, Nagano (Japan); Watanabe, T. [Saku Central Hospital, Usuda, Nagano (Japan); Kondo, T. [Matsumoto Dental College, Shiojiri, Nagano (Japan); Sakurai, S. [Otsuma Women' s University, Tama, Tokyo (Japan); Ji, R.; Liang, C.; Cao, S. [Institute of Environmental Health and Engineering, Beijing (China); Hong, Z. [Shanxi Maternity and Children' s Hospital, Taiyuan (China)

    2001-04-23

    Recently a huge amount of fluoride in coal has been released into indoor environments by the combustion of coal and fluoride pollution seems to be increasing in some rural areas in China. Combustion of coal and coal bricks is the primary source of gaseous and aerosol fluoride and these forms of fluoride can easily enter exposed food products and the human respiratory tract. Major human fluoride exposure was caused by consumption of fluoride contaminated food, such as corn, chilies and potatoes. For each diagnostic syndrome of dental fluorosis, a log-normal distribution was observed on the logarithm of urinary fluoride concentration in students in China. Urinary fluoride content was found to be a primary health indicator of the prevalence of dental fluorosis in the community. In the fluorosis areas, osteosclerosis in skeletal fluorosis patients was observed with a high prevalence. A biochemical marker of bone resorption, urinary deoxypyridinoline content was much higher in residents in China than in residents in Japan. It was suggested that bone resorption was stimulated to a greater extent in residents in China and fluoride may stimulate both bone resorption and bone formation. Renal function especially glomerular filtration rate was very sensitive to fluoride exposure. Inorganic phosphate concentrations in urine were significantly lower in the residents in fluorosis areas in China than in non-fluorosis area in China and Japan. Since airborne fluoride from the combustion of coal pollutes extensively both the living environment and food, it is necessary to reduce fluoride pollution caused by coal burning.

  16. Evaluation of melioration area damage on the river Danube caused by the hydroelectric power plant 'Djerdap 1' backwater.

    Science.gov (United States)

    Pajic, P; Andjelic, L; Urosevic, U; Polomcic, D

    2014-01-01

    Construction of the hydroelectric power plant (HPP) 'Djerdap 1' formed a backwater effect on the Danube and its tributaries, which had an inevitable influence on groundwater level, causing it to rise and thus creating additional threats to all melioration areas on more than 300 km of the Danube riversides, as well as on the riversides of its tributaries: the Sava (100 km) and the Tisa (60 km). In this paper, the HPP 'Djerdap 1' backwater effect on some characteristic melioration areas (34 in all) has been analyzed. In most of these areas intensive agricultural activity has always been present. An assessment of agricultural production damage was carried out by complex hydrodynamic calculations (60 calculation profiles) for different backwater regimes, with the aim to precisely quantify the HPP 'Djerdap 1' backwater effect on groundwater piezometric levels. Combining them with complex agroeconomic analyses, the aim is to quantify agricultural production damage and to consider the perspective of melioration area users. This method, which combines two different, but compatible, aspects of the melioration area threat assessment (hydrodynamic and agroeconomic), may present a quality base for further agricultural production threat assessment on all melioration areas on the Danube riversides, with the final aim to consider the economic effects and the importance of its further protection.

  17. Image analysis of epicuticular damage to foliage caused by dry deposition of the air pollutant nitric acid.

    Science.gov (United States)

    Padgett, Pamela E; Parry, Sally D; Bytnerowicz, Andrzej; Heath, Robert L

    2009-01-01

    Nitric acid vapor is produced by the same photochemical processes that produce ozone. In the laboratory, concentrated nitric acid is a strong acid and a powerful oxidant. In the environment, where the concentrations are much lower, it is an innocuous source of plant nitrogen. As an air pollutant, which mode of action does dry deposition of nitric acid follow? We investigated the effects of dry deposition of nitric acid on the foliage of four tree species native to the western United States. A novel controlled environment, fumigation system enabled a four-week exposure at concentrations consistent with ambient diurnal patterns. Scanning electron microscopy and automated image analysis revealed changes in the epicuticular wax layer during fumigation. Exposure to nitric acid resulted in a reproducible suite of damage symptoms that increased with increasing dose. Each tree species tested exhibited a unique set of damage features, including cracks, lesions, and conformation changes to epicuticular crystallite structures. Dry deposition of atmospheric nitric acid caused substantial perturbation to the epicuticular surface of all four tree species investigated, consistent with the chemical oxidation of epicuticular waxes. Automated image analysis eliminated many biases that can trouble microscopy studies. Trade names and commercial enterprises or products are mentioned solely for information. No endorsements by the U.S. Department of Agriculture are implied.

  18. Oxidative damage of U937 human leukemic cells caused by hydroxyl radical results in singlet oxygen formation.

    Directory of Open Access Journals (Sweden)

    Marek Rác

    Full Text Available The exposure of human cells to oxidative stress leads to the oxidation of biomolecules such as lipids, proteins and nuclei acids. In this study, the oxidation of lipids, proteins and DNA was studied after the addition of hydrogen peroxide and Fenton reagent to cell suspension containing human leukemic monocyte lymphoma cell line U937. EPR spin-trapping data showed that the addition of hydrogen peroxide to the cell suspension formed hydroxyl radical via Fenton reaction mediated by endogenous metals. The malondialdehyde HPLC analysis showed no lipid peroxidation after the addition of hydrogen peroxide, whereas the Fenton reagent caused significant lipid peroxidation. The formation of protein carbonyls monitored by dot blot immunoassay and the DNA fragmentation measured by comet assay occurred after the addition of both hydrogen peroxide and Fenton reagent. Oxidative damage of biomolecules leads to the formation of singlet oxygen as conformed by EPR spin-trapping spectroscopy and the green fluorescence of singlet oxygen sensor green detected by confocal laser scanning microscopy. It is proposed here that singlet oxygen is formed by the decomposition of high-energy intermediates such as dioxetane or tetroxide formed by oxidative damage of biomolecules.

  19. Calculation of Core Damage Frequency for the Change of the Common Cause Failure Parameters According to the Testing Strategies

    International Nuclear Information System (INIS)

    Kang, Dae Il; Kim, Kil You; Jin, Young Ho; Kim, Tae Woon

    2011-01-01

    Common cause failure (CCF) probabilities are differently estimated according to testing strategies. There are two representative testing schemes; staggered testing and non-staggered testing schemes. For the cases where trains or channels of standby safety systems consisting of more than two redundant components are tested in a staggered manner, the standby safety components within a train can be tested simultaneously or consecutively. In this case, mixed testing scheme, staggered and non-staggered testing schemes, are used for testing the components. Kang et al. derived the formulas for the estimations of the CCF probabilities of the components under the mixed testing scheme. This paper presents the sensitivity study results on the core damage frequency (CDF) of the SMART (System-integrated Modular Advanced Reactor) for the changes of the CCF parameters according to the testing strategies

  20. Enterococcus faecalis Infection Causes Inflammation, Intracellular Oxphos-Independent ROS Production, and DNA Damage in Human Gastric Cancer Cells

    DEFF Research Database (Denmark)

    Strickertsson, Jesper A. B; Desler, Claus; Martin-Bertelsen, Tomas

    2013-01-01

    Background Achlorhydria caused by e.g. atrophic gastritis allows for bacterial overgrowth, which induces chronic inflammation and damage to the mucosal cells of infected individuals driving gastric malignancies and cancer. Enterococcus faecalis (E. faecalis) can colonize achlohydric stomachs and we...... therefore wanted to study the impact of E. faecalis infection on inflammatory response, reactive oxygen species (ROS) formation, mitochondrial respiration, and mitochondrial genetic stability in gastric mucosal cells. Methods To separate the changes induced by bacteria from those of the inflammatory cells...... we established an in vitro E. faecalis infection model system using the gastric carcinoma cell line MKN74. Total ROS and superoxide was measured by fluorescence microscopy. Cellular oxygen consumption was characterized non-invasively using XF24 microplate based respirometry. Gene expression...

  1. Biological and chemical diagnosis of damage to crops caused by air pollution and tracing the source of pollution

    Energy Technology Data Exchange (ETDEWEB)

    Van Raay, A

    1975-01-01

    This paper deals with the biological and chemical diagnosis of damage of crops caused by air pollution. Field observations were made as well as trials in fumigation chambers. The field work showed a great deal of fluoride contamination near industrial plants. A network of monitoring points was set up around the fluoride-emitting sources. The HF pollution was determined by the limed paper method, the fluoride content of plants, leaf necrosis in some plants, and an impinger and tubes filled with coated silver pellets, directed by a weather-vane. These investigations were carried out in two areas of New Zealand as well as near Delfzijl in Groningen. Fluoride was emitted by factories producing aluminum, superphosphate or sodium triphosphate.

  2. Assessing the damage caused by the oil spill from the tanker Erika; Erika: elements d'evaluation des dommages

    Energy Technology Data Exchange (ETDEWEB)

    Delache, X.; Erhard-Cassegrain, A

    2001-07-01

    In December 1999, France was faced with a large-scale marine and ecological disaster following the accident involving the oil tanker Erika which split in two before sinking off the coast of Brittany (western France). This disaster had significant impacts on the coastal environment, affecting 400 km of shoreline. Very different aspects need to be considered in order to assess the damage caused, for which suitable methodologies must be used. Expenditure incurred on emergency and remedial measures to prepare for the 2000 summer season can easily be identified. The main effect of the disaster was ecological: a wide variety of habitats and species, and in particular many protected areas were affected. In addition, economic activities were seriously disrupted, especially tourism, fishing and shellfish production. However, it is harder to assess the economic losses incurred since a large number of short-term and long-term factors were affected. (author)

  3. Using Information from Rendezvous Missions for Best-Case Appraisals of Impact Damage to Planet Earth Caused by Natural Objects

    Science.gov (United States)

    Arnold, James O.; Chodas, Paul W.; Ulamec, Stephan; Mathias, Donovan L.; Burkhard, Craig D.

    2017-01-01

    The Asteroid Threat Assessment Project (ATAP), a part of NASAs Planetary Defense Coordination Office (PDCO) has the responsibility to appraise the range of surface damage by potential asteroid impacts on land or water. If a threat is realized, the project will provide appraisals to officials empowered to make decisions about potential mitigation actions. This paper describes a scenario for assessment of surface damage when characterization of an asteroid had been accomplished by a rendezvous mission that would be conducted by the international planetary defense community. It is shown that the combination of data from ground and in-situ measurements on an asteroid provides knowledge that can be used to pin-point its impact location and predict the level of devastation it would cause. The hypothetical asteroid 2017 PDC with a size range of 160 to 290 m in diameter to be discussed at the PDC 2017 is used as an example. In order of importance for appraising potential damage, information required is: (1) where will the surface impact occur? (2) what is the mass, shape and size of the asteroid and what is its entry state (speed and entry angle) at the 100 km atmospheric pierce point? And (3) is the asteroid a monolith or a rubble pile? If it is a rubble pile, what is its structure and heterogeneity from the surface and throughout its interior? Item (1) is of first order importance to determine levels of devastation (loss of life and infrastructure damage) because it varies strongly on the impact location. Items (2) and (3) are used as inputs for ATAPs simulations to define the level of surface hazards: winds, overpressure, thermal exposure; all created by the deposition of energy during the objects atmospheric flight, andor cratering. Topics presented in this paper include: (i) the devastation predicted by 2017 PDCs impact on land based on initial observations using ATAPs risk assessment capability, (ii) how information corresponding to items (1) to (3) could be obtained

  4. Fish Health Study Ashtabula River Natural Resource Damage Assessment

    Science.gov (United States)

    Blazer, V.S.; Iwanowicz, L.R.; Baumann, P.C.

    2006-01-01

    INTRODUCTION The Ashtabula River is located in northeast Ohio, flowing into Lake Erie at Ashtabula, Ohio. Tributaries include Fields Brook, Hubbard Run, Strong Brook, and Ashtabula Creek. The bottom sediments, bank soils and biota of Fields Brook have been severely contaminated by unregulated discharges of hazardous substances. Hazardous substances have migrated downstream from Fields Brook to the Ashtabula River and Harbor, contaminating bottom sediments, fish and wildlife. There are presently more than 1,000,000 cubic yards of contaminated sediment in the Ashtabula River and Harbor, much of which originated from Fields Brook. Contaminants include polychlorinated biphenyls (PCBs), chlorinated benzenes, chlorinated ethenes, hexachlorobutadiene, polyaromatic hydrocarbons (PAHs), other organic chemicals, heavy metals and low level radionuclides. A Preassessment Screen, using existing data, was completed for the Ashtabula River and Harbor on May 18, 2001. Among the findings was that the fish community at Ashtabula contained approximately 45 percent fewer species and 52 percent fewer individuals than the Ohio EPA designated reference area, Conneaut Creek. The Ashtabula River and Conneaut Creek are similar in many respects, with the exception of the presence of contamination at Ashtabula. The difference in the fish communities between the two sites is believed to be at least partially a result of the hazardous substance contamination at Ashtabula. In order to investigate this matter further, the Trustees elected to conduct a study of the status and health of the aquatic biological communities of the Ashtabula River and Conneaut Creek in 2002-2004. The following document contains brief method descriptions (more detail available in attached Appendix A) and a summary of the data used to evaluate the health status of brown bullheads (Ameiurus nebulosus) and largemouth bass (Micropterus salmoides) collected from the above sites.

  5. Assessment of thermal fatigue damage caused by local fluid temperature fluctuation (part I: characteristics of constraint and stress caused by thermal striation and stratification)

    International Nuclear Information System (INIS)

    Kamaya, Masayuki

    2014-01-01

    Highlights: • The source of the membrane constraint due to local temperature fluctuation was shown. • Thermal fatigue that occurred at a mixing tee and branched elbow was analyzed. • Cracking occurrence was reasonably explained by the constraint and stress conditions. - Abstract: This study was aimed at identifying the constraint conditions under local temperature fluctuation by thermal striping at a mixing tee and by thermal stratification at an elbow pipe branched from the main pipe. Numerical and analytical approaches were made to derive the thermal stress and its fluctuation. It was shown that an inhomogeneous temperature distribution in a straight pipe caused thermal stress due to a membrane constraint even if an external membrane constraint did not act on the pipe. Although the membrane constraint increased the mean stress at the mixing tee, it did not contribute to fluctuation of the thermal stress. On the other hand, the membrane constraint played an important role in the fatigue damage accumulation near the stratification layer of the branched elbow. Based on the constraint and stress conditions analyzed, the characteristics of the cracking observed in actual nuclear power plants were reasonably explained. Namely, at the mixing tee, where thermal crazing has been found, the lack of contribution of the membrane constraint to stress fluctuation caused a stress gradient in the thickness direction and arrested crack growth. On the other hand, at the branched elbow, where axial through-wall cracks have been found, the relatively large hoop stress fluctuation was brought about by movement of the stratified layer together with the membrane constraint even under a relatively low frequency of stress fluctuation

  6. Secondary radiation damage as the main cause for unexpected volume effects: A histopathologic study of the parotid gland

    International Nuclear Information System (INIS)

    Konings, Antonius W.T.; Faber, Hette; Cotteleer, Femmy; Vissink, Arjan; Coppes, Rob P.

    2006-01-01

    Purpose: To elucidate with a histopathological study the mechanism of region-dependent volume effects in the partly irradiated parotid gland of the rat. Methods and Materials: Wistar rats were locally X-irradiated with collimators with conformal radiation portals for 100% volume and 50% cranial/caudal partial volumes. Single doses up to 40 Gy were applied. Parotid saliva samples were collected, and the three lobes of the parotid gland were examined individually on the macro- and micromorphologic level up to 1 year after irradiation. Results: Dose-dependent loss of gland weight was observed 1 year after total or partial X-irradiation. Weight loss of the glands correlated very well with loss of secretory function. Irradiating the cranial 50% volume (implicating a shielded lateral lobe) resulted in substantially more damage in terms of weight loss and loss of secretory function than 50% caudal irradiation (shielding the ventral and dorsal lobe). Histologic examinations of the glands 1 year after irradiation revealed that the shielded lateral lobe was severely affected, in contrast to the shielded ventral and dorsal lobes. Time studies showed that irradiation of the cranial 50% volume caused late development of secondary damage in the shielded lateral lobe, becoming manifest between 240 and 360 days after irradiation. The possible clinical significance of this finding is discussed. Conclusion: It is concluded that the observed region-dependent volume effect for late function loss in the rat parotid gland after partial irradiation is mainly caused by secondary events in the shielded lateral lobe. The most probable first step (primary radiation event) in the development of this secondary damage is radiation exposure to the hilus region (located between the ventral and dorsal lobe). By injuring major excretory ducts and supply routes for blood and nerves in this area, the facility system necessary for proper functioning of the nonexposed lateral lobe is seriously affected

  7. Polymorphisms in metabolism and repair genes affects DNA damage caused by open-cast coal mining exposure.

    Science.gov (United States)

    Espitia-Pérez, Lyda; Sosa, Milton Quintana; Salcedo-Arteaga, Shirley; León-Mejía, Grethel; Hoyos-Giraldo, Luz Stella; Brango, Hugo; Kvitko, Katia; da Silva, Juliana; Henriques, João A P

    2016-09-15

    Increasing evidence suggest that occupational exposure to open-cast coal mining residues like dust particles, heavy metals and Polycyclic Aromatic Hydrocarbons (PAHs) may cause a wide range of DNA damage and genomic instability that could be associated to initial steps in cancer development and other work-related diseases. The aim of our study was to evaluate if key polymorphisms in metabolism genes CYP1A1Msp1, GSTM1Null, GSTT1Null and DNA repair genes XRCC1Arg194Trp and hOGG1Ser326Cys could modify individual susceptibility to adverse coal exposure effects, considering the DNA damage (Comet assay) and micronucleus formation in lymphocytes (CBMN) and buccal mucosa cells (BMNCyt) as endpoints for genotoxicity. The study population is comprised of 200 healthy male subjects, 100 open-cast coal-mining workers from "El Cerrejón" (world's largest open-cast coal mine located in Guajira - Colombia) and 100 non-exposed referents from general population. The data revealed a significant increase of CBMN frequency in peripheral lymphocytes of occupationally exposed workers carrying the wild-type variant of GSTT1 (+) gene. Exposed subjects carrying GSTT1null polymorphism showed a lower micronucleus frequency compared with their positive counterparts (FR: 0.83; P=0.04), while BMNCyt, frequency and Comet assay parameters in lymphocytes: Damage Index (DI) and percentage of DNA in the tail (Tail % DNA) were significantly higher in exposed workers with the GSTM1Null polymorphism. Other exfoliated buccal mucosa abnormalities related to cell death (Karyorrhexis and Karyolysis) were increased in GSTT/M1Null carriers. Nuclear buds were significantly higher in workers carrying the CYP1A1Msp1 (m1/m2, m2/m2) allele. Moreover, BMNCyt frequency and Comet assay parameters were significantly lower in exposed carriers of XRCC1Arg194Trp (Arg/Trp, Trp/Trp) and hOGG1Ser326Cys (Ser/Cys, Cys/Cys), thereby providing new data to the increasing evidence about the protective role of these polymorphisms

  8. Do native parasitic plants cause more damage to exotic invasive hosts than native non-invasive hosts? An implication for biocontrol.

    Science.gov (United States)

    Li, Junmin; Jin, Zexin; Song, Wenjing

    2012-01-01

    Field studies have shown that native, parasitic plants grow vigorously on invasive plants and can cause more damage to invasive plants than native plants. However, no empirical test has been conducted and the mechanism is still unknown. We conducted a completely randomized greenhouse experiment using 3 congeneric pairs of exotic, invasive and native, non-invasive herbaceous plant species to quantify the damage caused by parasitic plants to hosts and its correlation with the hosts' growth rate and resource use efficiency. The biomass of the parasitic plants on exotic, invasive hosts was significantly higher than on congeneric native, non-invasive hosts. Parasites caused more damage to exotic, invasive hosts than to congeneric, native, non-invasive hosts. The damage caused by parasites to hosts was significantly positively correlated with the biomass of parasitic plants. The damage of parasites to hosts was significantly positively correlated with the relative growth rate and the resource use efficiency of its host plants. It may be the mechanism by which parasitic plants grow more vigorously on invasive hosts and cause more damage to exotic, invasive hosts than to native, non-invasive hosts. These results suggest a potential biological control effect of native, parasitic plants on invasive species by reducing the dominance of invasive species in the invaded community.

  9. Effect of Caffeic Acid Phenethyl Ester on Vascular Damage Caused by Consumption of High Fructose Corn Syrup in Rats

    OpenAIRE

    Gun, Aburrahman; Ozer, Mehmet Kaya; Bilgic, Sedat; Kocaman, Nevin; Ozan, Gonca

    2016-01-01

    Fructose corn syrup is cheap sweetener and prolongs the shelf life of products, but fructose intake causes hyperinsulinemia, hypertriglyceridemia, and hypertension. All of them are referred to as metabolic syndrome and they are risk factors for cardiovascular diseases. Hence, the harmful effects of increased fructose intake on health and their prevention should take greater consideration. Caffeic Acid Phenethyl Ester (CAPE) has beneficial effects on metabolic syndrome and vascular function wh...

  10. Damage Detection with Streamlined Structural Health Monitoring Data

    Directory of Open Access Journals (Sweden)

    Jian Li

    2015-04-01

    Full Text Available The huge amounts of sensor data generated by large scale sensor networks in on-line structural health monitoring (SHM systems often overwhelms the systems’ capacity for data transmission and analysis. This paper presents a new concept for an integrated SHM system in which a streamlined data flow is used as a unifying thread to integrate the individual components of on-line SHM systems. Such an integrated SHM system has a few desirable functionalities including embedded sensor data compression, interactive sensor data retrieval, and structural knowledge discovery, which aim to enhance the reliability, efficiency, and robustness of on-line SHM systems. Adoption of this new concept will enable the design of an on-line SHM system with more uniform data generation and data handling capacity for its subsystems. To examine this concept in the context of vibration-based SHM systems, real sensor data from an on-line SHM system comprising a scaled steel bridge structure and an on-line data acquisition system with remote data access was used in this study. Vibration test results clearly demonstrated the prominent performance characteristics of the proposed integrated SHM system including rapid data access, interactive data retrieval and knowledge discovery of structural conditions on a global level.

  11. Damage detection with streamlined structural health monitoring data.

    Science.gov (United States)

    Li, Jian; Deng, Jun; Xie, Weizhi

    2015-04-15

    The huge amounts of sensor data generated by large scale sensor networks in on-line structural health monitoring (SHM) systems often overwhelms the systems' capacity for data transmission and analysis. This paper presents a new concept for an integrated SHM system in which a streamlined data flow is used as a unifying thread to integrate the individual components of on-line SHM systems. Such an integrated SHM system has a few desirable functionalities including embedded sensor data compression, interactive sensor data retrieval, and structural knowledge discovery, which aim to enhance the reliability, efficiency, and robustness of on-line SHM systems. Adoption of this new concept will enable the design of an on-line SHM system with more uniform data generation and data handling capacity for its subsystems. To examine this concept in the context of vibration-based SHM systems, real sensor data from an on-line SHM system comprising a scaled steel bridge structure and an on-line data acquisition system with remote data access was used in this study. Vibration test results clearly demonstrated the prominent performance characteristics of the proposed integrated SHM system including rapid data access, interactive data retrieval and knowledge discovery of structural conditions on a global level.

  12. [Survey on a public health emergency event caused by norovirus].

    Science.gov (United States)

    Xing, Y; Jiang, C; Hua, W Y; Liu, F; Zhao, Z; Ding, Y J; Wang, L; Li, J

    2017-09-10

    Objective: To study the epidemiological characteristics of an outbreak caused by norovirus infection in a school in Haidian district, Beijing. Methods: Basic information of the school and data related to patients in the fields survey were collected and analyzed descriptively. Laboratory tests were performed to test the stool and anal swab specimens of both patients and cooks as well as the environmental specimens. Risk factors related to the incidence were analyzed through a case-control study. Results: A total number of 119 patients were identified in the school. Clinical symptoms were mild, mainly involving vomiting (94.1 % , 112/119), abdominal pain (46.2 % , 55/119), but no need of hospitalization. The average age of the student patients was 6.38, with minimum and maximum between 5 and 11. Patients were found in 22 classes, but mainly in grade 1 and class 7 where 35 patients were found (30.17 % ). A total of 134 specimens of rectal swabs and stool were collected, with 7 positive for norovirus and 6 for sappovirus. Salmonella, Shigella, lapactic Escherichia coli and Vibrio parahaemolyticus were not found in on dinner sets, residual foods, bottled water or in drinking fountains. Index on water hygiene was unsatisfactory in classrooms or dormitories where more cases were found. Accommodation, north-facing-classrooms, abnormal water hygiene indexes were found related to the occurance of the disease ( P <0.05). Conclusions: The outbreak was identified a gastroenteritis infection, caused by norovirus with symptoms as vomiting and abdominal pain. This event reached the reporting standards of public health emergencies-level Ⅳ. Discovery and isolation of the first case was not timely while transmission of the disease might be water-borne. Surveillance programs on symptoms, disinfection of vomit and stool in places like nurseries and schools should be strengthened to prevent the norovirus outbreak.

  13. [Public health risk caused by emissions from refuse incinerators].

    Science.gov (United States)

    Wassermann, O; Kruse, H

    1995-01-01

    An irresponsible "approval on request" in favour of waste incineration written by a consulting committee of the German Federal Board of Physicians has meanwhile been widely distributed both nationally and internationally. The aim of this politically motivated paper is to dramatically increase the present number of 49 waste incinerators in Germany. It is our duty to warn of this intention. Health problems are known to exist both in workers at waste incinerators and in humans living in their vicinity. Furthermore, in the long run negative impact also to ecosystems should be expected from the emissions. Health problems in patients living downwind of waste incinerators repeatedly have been reported on by physicians. "Lack of statistical significance", often used as counter-argument, is only due to absence of funding of comprehensive epidemiological studies in Germany. Analyses of soil samples reveal the pollution from waste incineration. Considering the pre-load of the region, additional emissions caused by waste incineration and other sources have to be assessed. The application of preventive limit values is imperative. The presently used "limit values", being about 100 times too high, bear an unacceptable risk. Therefore, reliable regional registers of emissions have to be established immediately. Limit values continuously have to be adjusted to the progress of scientific knowledge. In this respect it is imperative to consider that the actual composition of emissions is unknown; isolated risk assessment of single compounds underestimates the total risk; the negative impact, e.g. of dioxins, on both the immune and hormone systems occurs at concentrations 100 times lower than those causing carcinogenic effects; the assumption of "threshold values" is obsolete; a considerable lack of knowledge exists about accumulation in food webs and in ecosystems; the demand of preservation of natural, geogenic situations is indispensable in assessments of soil and water pollution

  14. Damage assessment using flexibility and flexibility-based curvature for structural health monitoring

    International Nuclear Information System (INIS)

    Catbas, F N; Gul, M; Burkett, J L

    2008-01-01

    As a result of the recent advances in sensors, information technologies and material science, a considerable amount of research has been conducted in the area of smart infrastructures. While there are many important components of a smart infrastructure, an automated and continuous structural health monitoring (SHM) system is a critical one. SHM is typically used to track and evaluate the performance of a structure, symptoms of operational incidents, anomalies due to deterioration and damage during regular operation as well as after an extreme event. Successful health monitoring applications can be achieved by integrating experimental, analytical and information technologies on real-life operating structures. However, real-life investigations must be backed up by laboratory benchmark studies for validating theory, concepts, and new technologies. For this reason, a physical bridge model is developed to implement SHM methods and technologies. In this study, different aspects of model development are outlined in terms of design considerations, instrumentation, finite element modeling, and simulating damage scenarios. Different damage detection methods are evaluated using the numerical and the physical models. Modal parameter estimation studies are carried out to reliably identify the eigenvalues, eigenvectors and modal scaling from the measurement data. To assess the simulated damage, modal flexibility-based displacements and curvatures are employed. Structural behavior after damage is evaluated by inspecting the deflected shapes obtained using modal flexibility. More localized damage simulations such as stiffness reduction at a joint yield a very subtle stiffness decrease. In this case, the writers use a baseline to identify damage and also investigate the use of curvature as a complementary index. Curvature is advantageous for certain cases where the displacement results do not provide substantial changes. Issues related to using curvature as a damage identification

  15. Design of a piezoelectric-based structural health monitoring system for damage detection in composite materials

    Science.gov (United States)

    Kessler, Seth S.; Spearing, S. Mark

    2002-07-01

    Cost-effective and reliable damage detection is critical for the utilization of composite materials. This paper presents the conclusions of an experimental and analytical survey of candidate methods for in-situ damage detection in composite structures. Experimental results are presented for the application of modal analysis and Lamb wave techniques to quasi-isotropic graphite/epoxy test specimens containing representative damage. Piezoelectric patches were used as actuators and sensors for both sets of experiments. Modal analysis methods were reliable for detecting small amounts of global damage in a simple composite structure. By comparison, Lamb wave methods were sensitive to all types of local damage present between the sensor and actuator, provided useful information about damage presence and severity, and present the possibility of estimating damage type and location. Analogous experiments were also performed for more complex built-up structures. These techniques are suitable for structural health monitoring applications since they can be applied with low power conformable sensors and can provide useful information about the state of a structure during operation. Piezoelectric patches could also be used as multipurpose sensors to detect damage by a variety of methods such as modal analysis, Lamb wave, acoustic emission and strain based methods simultaneously, by altering driving frequencies and sampling rates. This paper present guidelines and recommendations drawn from this research to assist in the design of a structural health monitoring system for a vehicle. These systems will be an important component in future designs of air and spacecraft to increase the feasibility of their missions.

  16. Piper nigrum ethanolic extract rich in piperamides causes ROS overproduction, oxidative damage in DNA leading to cell cycle arrest and apoptosis in cancer cells.

    Science.gov (United States)

    de Souza Grinevicius, Valdelúcia Maria Alves; Kviecinski, Maicon Roberto; Santos Mota, Nádia Sandrini Ramos; Ourique, Fabiana; Porfirio Will Castro, Luiza Sheyla Evenni; Andreguetti, Rafaela Rafognato; Gomes Correia, João Francisco; Filho, Danilo Wilhem; Pich, Claus Tröger; Pedrosa, Rozangela Curi

    2016-08-02

    Ayurvedic and Chinese traditional medicine and tribal people use herbal preparations containing Piper nigrum fruits for the treatment of many health disorders like inflammation, fever, asthma and cancer. In Brazil, traditional maroon culture associates the spice Piper nigrum to health recovery and inflammation attenuation. The aim of the current work was to evaluate the relationship between reactive oxygen species (ROS) overproduction, DNA fragmentation, cell cycle arrest and apoptosis induced by Piper nigrum ethanolic extract and its antitumor activity. The plant was macerated in ethanol. Extract constitution was assessed by TLC, UV-vis and ESI-IT-MS/MS spectrometry. The cytotoxicity, proliferation and intracellular ROS generation was evaluated in MCF-7 cells. DNA damage effects were evaluated through intercalation into CT-DNA, plasmid DNA cleavage and oxidative damage in CT-DNA. Tumor growth inhibition, survival time increase, apoptosis, cell cycle arrest and oxidative stress were assessed in Ehrlich ascites carcinoma-bearing mice. Extraction yielded 64mg/g (36% piperine and 4.2% piperyline). Treatments caused DNA damage and reduced cell viability (EC50=27.1±2.0 and 80.5±6.6µg/ml in MCF-7 and HT-29 cells, respectively), inhibiting cell proliferation by 57% and increased ROS generation in MCF-7 cells (65%). Ehrlich carcinoma was inhibited by the extract, which caused reduction of tumor growth (60%), elevated survival time (76%), cell cycle arrest and induced apoptosis. The treatment with extract increased Bax and p53 and inhibited Bcl-xL and cyclin A expression. It also induced an oxidative stress in vivo verified as enhanced lipid peroxidation and carbonyl proteins content and increased activities of glutathione reductase, superoxide dismutase and catalase. GSH concentration was decreased in tumor tissue from mice. The ethanolic extract has cytotoxic and antiproliferative effect on MCF-7 cells and antitumor effect in vivo probably due to ROS overproduction

  17. Structural health and dynamic behavior of residential buildings: field challenges in the rehab of damaged reinforced concrete

    Directory of Open Access Journals (Sweden)

    Chalhoub M. S.

    2014-01-01

    Full Text Available Reinforced concrete buildings require special consideration under dynamic excitations due to their anisotropic material properties. Strain compatibility equations are used in concrete analysis and design with assumptions about the stress and strain field across member section and member length. However, these assumptions fall short of describing real life behavior when concrete elements deteriorate, age or undergo cyclic loading. This paper addresses the structural health of reinforced concrete buildings and proposes an analytical model to account for concrete damage through loss of bond. The proposed model relates steel loading that causes bond distress to design parameters such as development length and bar properties, and therefore could be complemented by field measurement. The paper proposes a diagnosis method and discusses the sustainability of the structure by assisting in a simplistic decision rule as to whether to perform minor fixes, major rehabilitation, or disposal. Emphasis is placed on the difference between reversible and irreversible effects of cyclic loading on structural behaviour, and draws a distinction between damage to the girder and damage to the column in the overall structural system. The model is compared to empirical results to address field challenges faced when the structure is subjected to severe conditions in its ambient environment, or to unusual loading. Deterioration in concrete causes alteration in its composite behavior with the reinforcing steel. This affects the fundamental period of the structure, and its response to seismic loading.

  18. Health symptoms caused by molds in a courthouse.

    Science.gov (United States)

    Lee, Tang G

    2003-07-01

    A majority of occupants of a newly renovated historic courthouse in Calgary, Alberta, Canada, reported multiple (3 or more) health-related symptoms, and several reported more than 10 persistent symptoms. Most required at least 1 day outside of the building to recover from their symptoms. Molds that produce mycotoxins, such as Stachybotrys chartarum and Emericella nidulans, were identified in the building, along with fungal organisms of the genera Aspergillus, Penicillium, Streptomyces, Cladosporium, Chaetomium, Rhizopus/Mucor, Alternaria, Ulocladium, and Basidiomycetes. Renovations to this historic had building failed to provide adequate thermal and vapor barriers, thus allowing moist indoor air to migrate into the building enclosure, causing condensation to develop. Mold grew on the condensation and was dispersed throughout the courthouse, including on furniture and files. The courthouse was closed and a new facility was modified with low-offgassing materials, better ventilation and air filtration, and strict building maintenance to accommodate those occupants of the older building who had developed multiple chemical sensitivities.

  19. Vitamin E protects against the mitochondrial damage caused by cyclosporin A in LLC-PK1 cells

    International Nuclear Information System (INIS)

    Arriba, G. de; Perez de Hornedo, J.; Ramirez Rubio, S.; Calvino Fernandez, M.; Benito Martinez, S.; Maiques Camarero, M.; Parra Cid, T.

    2009-01-01

    Cyclosporin A (CsA) has nephrotoxic effects known to involve reactive oxygen species (ROS), since antioxidants prevent the kidney damage induced by this drug. Given that mitochondria are among the main sources of intracellular ROS, the aims of our study were to examine the mitochondrial effects of CsA in the porcine renal endothelial cell line LLC-PK1 and the influence of the antioxidant Vitamin E (Vit E). Following the treatment of LLC-PK1 cells with CsA, we assessed the mitochondrial synthesis of superoxide anion, permeability transition pore opening, mitochondrial membrane potential, cardiolipin peroxidation, cytochrome c release and cellular apoptosis, using flow cytometry and confocal microscopy procedures. Similar experiments were done after Vit E preincubation of cells. CsA treatment increased superoxide anion in a dose-dependent way. CsA opened the permeability transition pores, caused Bax migration to mitochondria, and decreased mitochondrial membrane potential and cardiolipin content. Also CsA released cytochrome c into cytosol and provoked cellular apoptosis. Vit E pretreatment inhibited the effects that CsA induced on mitochondrial structure and function in LLC-PK1 cells and avoided apoptosis. CsA modifies mitochondrial LLC-PK1 cell physiology with loss of negative electrochemical gradient across the inner mitochondrial membrane and increased lipid peroxidation. These features are related to apoptosis and can explain the cellular damage that CsA induces. As Vit E inhibited these effects, our results suggest that they were mediated by an increase in ROS production by mitochondria.

  20. Root canal treatment of a periradicular lesion caused by unintentional root damage after orthodontic miniscrew placement: a case report.

    Science.gov (United States)

    Er, K; Bayram, M; Taşdemir, T

    2011-12-01

    To present the successful endodontic management of a maxillary lateral incisor tooth with a periradicular lesion caused by unintentional root damage after orthodontic miniscrew placement. A 22-year-old female was diagnosed with a skeletal Class II, Division 2 malocclusion with Class II molar and canine relationships on both sides. The treatment plan included distalization of the maxillary first molars bilaterally followed by full fixed appliance therapy. For the maxillary molar distalization, an appliance in conjunction with a miniscrew anchorage system was designed. Two months later, the patient came to the clinic with complaints of pain in the maxillary right lateral incisor region. On intraoral examination, intraoral sinus tracts were detected in the maxillary right buccal sulcus and palate. A large radiolucent lesion with a well-defined margin around the root of the maxillary right lateral incisor was seen. Root canal treatment was performed on the maxillary right lateral incisor tooth. The root canal was filled with gutta-percha and AH Plus sealer, using a lateral compaction technique. The final restoration of the tooth was completed using composite, and the tooth was reviewed after 10 months. The tooth was asymptomatic and radiographically showed repair of the lesion. Healing was achieved without any need for further endodontic or surgical intervention. Key learning points • This case illustrates the need to take care with miniscrews when performing orthodontic treatment, especially when the miniscrews are in close proximity to root apices. • The periradicular lesion as a result of miniscrew damage was successfully treated with root canal treatment. © 2011 International Endodontic Journal.

  1. Lactobacillus plantarum (VR1 isolated from an Ayurvedic medicine (Kutajarista ameliorates in vitro cellular damage caused by Aeromonas veronii

    Directory of Open Access Journals (Sweden)

    Patole Milind S

    2011-06-01

    Full Text Available Abstract Background Lactobacillus plantarum is considered as a safe and effective probiotic microorganism. Among various sources of isolation, traditionally fermented foods are considered to be rich in Lactobacillus spp., which can be exploited for their probiotic attribute. Antibacterial property of L. plantarum has been demonstrated against various enteric pathogens in both in vitro and in vivo systems. This study was aimed at characterizing L. plantarum isolated from Kutajarista, an ayurvedic fermented biomedicine, and assessing its antagonistic property against a common enteropathogen Aeromonas veronii. Results We report the isolation of L. plantarum (VR1 from Kutajarista, and efficacy of its cell free supernatant (CFS in amelioration of cytotoxicity caused by Aeromonas veronii. On the part of probiotic attributes, VR1 was tolerant to pH 2, 0.3% bile salts and simulated gastric juice. Additionally, VR1 also exhibited adhesive property to human intestinal HT-29 cell line. Furthermore, CFS of VR1 was antibacterial to enteric pathogens like Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Aeromonas veronii and clinical isolates of P. aeruginosa and E. coli. Detailed study regarding the effect of VR1 CFS on A. veronii cytotoxicity showed a significant decrease in vacuole formation and detrimental cellular changes in Vero cells. On the other hand, A. veronii CFS caused disruption of tight junction proteins ZO-1 and actin in MDCK cell line, which was prevented by pre-incubation with CFS of VR1. Conclusions This is the first study to report isolation of L. plantarum (VR1 from Kutajarista and characterisation for its probiotic attributes. Our study demonstrates the antagonistic property of VR1 to A. veronii and effect of VR1 CFS in reduction of cellular damage caused by A. veronii in both Vero and MDCK cell lines.

  2. Magnitude and Causes of Maternal Deaths at Health Facilities in ...

    African Journals Online (AJOL)

    indirect causes related to pregnancy, childbirth or postpartum period; 80 ... aggravated by pregnancy include malaria, anemia,. HIV/AIDS and ... for obstetric complications in 2007, 41 were classified as maternal deaths. The leading causes of ...

  3. Consequences and Possible Predictors of Health-damaging Behaviors and Mental Health Problems in Pregnancy - A Review.

    Science.gov (United States)

    Ulrich, F; Petermann, F

    2016-11-01

    In recent decades, the understanding of the short and longer term effects of health-damaging behaviors and mental health problems in pregnant women and the underlying mechanisms of these behaviors and illnesses has significantly increased. In contrast, little is known about the factors affecting individual pregnant women which contribute to health-damaging behaviors and mental illness. The aim of this paper was therefore to summarize the current state of research into the consequences of nicotine and alcohol consumption, malnutrition, excessive weight gain or obesity, and impaired mental health (depression and anxiety) during pregnancy. In addition, the characteristics of pregnant women which increase their risk of developing such behaviors or mental disorders are described. A better knowledge of these risks should make it easier for clinicians to identify cases at risk early on and put measures of support in place. A review of the literature has shown that certain characteristics of pregnant women (e.g. her relationship with her partner, a previous history of mental illness prior to pregnancy) are associated with various health-damaging behaviors as well as with impaired mental health. Affected women often show an accumulated psychosocial stress which was already present prior to the pregnancy and which may persist even after the birth of the child.

  4. Direct damage to vegetation caused by acid rain and polluted cloud: definition of critical levels for forest trees.

    Science.gov (United States)

    Cape, J N

    1993-01-01

    The concept of critical levels was developed in order to define short-term and long-term average concentrations of gaseous pollutants above which plants may be damaged. Although the usual way in which pollutants in precipitation (wet deposition) influence vegetation is by affecting soil processes, plant foliage exposed to fog and cloud, which often contain much greater concentrations of pollutant ions than rain, may be damaged directly. The idea of a critical level has been extended to define concentrations of pollutants in wet deposition above which direct damage to plants is likely. Concentrations of acidity and sulphate measured in mountain and coastal cloud are summarised. Vegetation at risk of injury is identified as montane forest growing close to the cloud base, where ion concentrations are highest. The direct effects of acidic precipitation on trees are reviewed, based on experimental exposure of plants to simulated acidic rain, fog or mist. Although most experiments have reported results in terms of pH (H(+) concentration), the accompanying anion is important, with sulphate being more damaging than nitrate. Both conifers and broadleaved tree seedlings showing subtle changes in the structural characteristics of leaf surfaces after exposure to mist or rain at or about pH 3.5, or sulphate concentration of 150 micromol litre(-1). Visible lesions on leaf surfaces occur at around pH 3 (500 micromol litre(-1) sulphate), broadleaved species tending to be more sensitive than conifers. Effects on photosynthesis and water relations, and interactions with other stresses (e.g. frost), have usually been observed only for treatments which have also caused visible injury to the leaf surface. Few experiments on the direct effects of polluted cloud have been conducted under field conditions with mature trees, which unlike seedlings in controlled conditions, may suffer a growth reduction in the absence of visible injury. Although leaching of cations (Ca(2+), Mg(2+), K(+)) is

  5. Renal deterioration caused by carcinogens as a consequence of free radical mediated tissue damage: a review of the protective action of melatonin

    Energy Technology Data Exchange (ETDEWEB)

    Gultekin, Fatih; Hicyilmaz, Hicran [Suleyman Demirel University, School of Medicine, Department of Biochemistry, Isparta (Turkey)

    2007-10-15

    This brief review summarizes some of the publications that document the preventive role of melatonin in kidney damage caused by carcinogens such as 2-nitropropane, arsenic, carbon tetrachloride, nitrilotriacetic acid and potassium bromate. Numerous chemicals generate excessive free radicals that eventually induce renal worsening. Melatonin partially or totally prevents free radical mediated tissue damages induced by many carcinogens. Protective actions of melatonin against the harmful effects of carcinogens are believed to stem from its direct free radical scavenging and indirect antioxidant activities. Dietary or pharmacologically given melatonin may attenuate the oxidative stress, thereby mitigating the subsequent renal damage. (orig.)

  6. Civil liability and compensation for damages caused by certain hazardous and noxious substances during their carriage by sea

    International Nuclear Information System (INIS)

    Bievre, A. de.

    1985-01-01

    In this paper current international efforts directed at the establishment of a special legal regime for civil liability and compensation for damages caused by hazardous and noxious substances during their transport by sea, specifically chemicals and liquid gas products, are described and analysed. Special attention is given to the way in which concern with the development of an 'environment oriented' regime which provides full recovery for victims in a reliable manner, on the one hand, and, on the other, considerations relating to cost effectiveness complement or conflict with each other. Another important area of investigation concerns the potential role of the marine insurance industry in accident prevention through the provision of incentives for careful (i.e. safe and environmentally sound) behaviour. There is a distinct regulatory trend in favour of strict liability (i.e. liability without fault) and compulsory insurance. There is also a growing perception of the need to depart from the traditional pattern of maritime liability which channels liability automatically to the person exercizing operational control during transport by sea (i.e. the carrier), and to additionally impose liability on those responsible for the risks attached to the inherently harmful characteristics of the cargoes carried. (orig.) [de

  7. Could mesenchymal stem cell therapy help in the treatment of muscle damage caused by Bothrops alternatus venom?

    Directory of Open Access Journals (Sweden)

    Thalita da Costa Telles

    2018-03-01

    Full Text Available ABSTRACT: The aim of this study was to evaluate the use of mesenchymal stem cells (MSC in the treatment of myonecrosis induced by Bothrops alternatus venom in rats. Seventy-five male adult Wistar rats were divided into three experimental groups. G1 and G2 were injected in the gastrocnemius muscle with 120μg of B. alternatus venom, while G3 received 200μL of PBS only. Three days after the venom injection, 12 rats from G1 were treated with 5.0 x 106 MSC in PBS, whereas G2 and G3 rats received PBS. Every three days, blood and muscle samples of five animals from each group were taken for serum biochemical and pathological analyses. Histological examinations showed more intense muscle lesions following MSC treatment, characterized by disorganization and loss of muscle fibers, with focal necrosis and inflammatory infiltration by mononuclear cells. In conclusion, the use of MSC for the treatment of local damage caused by inoculation of B. alternatus venom impaired muscle regeneration and interfered in the healing process.

  8. Use of enzymes to minimize the rheological dough problems caused by high levels of damaged starch in starch-gluten systems.

    Science.gov (United States)

    Barrera, Gabriela N; León, Alberto E; Ribotta, Pablo D

    2016-05-01

    During wheat milling, starch granules can experience mechanical damage, producing damaged starch. High levels of damaged starch modify the physicochemical properties of wheat flour, negatively affecting the dough behavior as well as the flour quality and cookie and bread making quality. The aim of this work was to evaluate the effect of α-amylase, maltogenic amylase and amyloglucosidase on dough rheology in order to propose alternatives to reduce the issues related to high levels of damaged starch. The dough with a high level of damaged starch became more viscous and resistant to deformations as well as less elastic and extensible. The soluble fraction of the doughs influenced the rheological behavior of the systems. The α-amylase and amyloglucosidase reduced the negative effects of high damaged starch contents, improving the dough rheological properties modified by damaged starch. The rheological behavior of dough with the higher damaged-starch content was related to a more open gluten network arrangement as a result of the large size of the swollen damaged starch granules. We can conclude that the dough rheological properties of systems with high damaged starch content changed positively as a result of enzyme action, particularly α-amylase and amyloglucosidase additions, allowing the use of these amylases and mixtures of them as corrective additives. Little information was reported about amyloglucosidase activity alone or combined with α-amylase. The combinations of these two enzymes are promising to minimize the negative effects caused by high levels of damaged starch on product quality. More research needs to be done on bread quality combining these two enzymes. © 2015 Society of Chemical Industry. © 2015 Society of Chemical Industry.

  9. Population dynamics and damage caused by the leaf miner Liriomyza huidobrensis Blanchard (Diptera: Agromyzidae), on seven potato processing varieties grown in temperate environment

    International Nuclear Information System (INIS)

    Lopez, R.; Carmona, D.; Vincini, A.M.; Monterubbianesi, G.; Caldiz, D.

    2010-01-01

    The leafminer Liriomyza huidobrensis Blanchard is considered a key pest for potatoes in Argentina. Population dynamics and leaf damage caused by the leafminer on seven selected potato processing varieties were assessed at Balcarce during the 2002 and 2003 growing seasons. Adult population dynamic was monitored using yellow sticky traps, while leaf damage (punctures and mines) was assessed using a damage index scale from low to severe. Liriomyza huidobrensis adults were present throughout the growing season and the population increased along crop development. The same was true for all varieties regarding larval damage, being low on early crop stages and severe late in the season. Varieties were grouped in two different categories according to damage scale index. Shepody, Kennebec, Frital and Innovator showed a higher damage index when compared with Santana, Ranger Russet and Russet Burbank, which exhibited a lower damage. Moreover, it could be assumed that damage was related to the foliage greenness, with light green colored varieties (Shepody, Kennebec, Frital and Innovator) being more attractive and affected by L. huidobrensis. (author)

  10. Self-rated health and all-cause and cause-specific mortality of older adults

    DEFF Research Database (Denmark)

    Bamia, Christina; Orfanos, Philippos; Juerges, Hendrik

    2017-01-01

    Objectives To evaluate, among the elderly, the association of self-rated health (SRH) with mortality, and to identify determinants of self-rating health as “at-least-good”. Study design Individual data on SRH and important covariates were obtained for 424,791 European and United States residents...... associations. Factors favourably associated with SRH were: sex (males), age (younger-old), education (high), marital status (married/cohabiting), physical activity (active), body mass index (non-obese), alcohol consumption (low to moderate) and previous morbidity (absence). Conclusion SRH provides a quick...... and simple tool for assessing health and identifying groups of elders at risk of early mortality that may be useful also in clinical settings. Modifying determinants of favourably rating health, e.g. by increasing physical activity and/or by eliminating obesity, may be important for older adults to “feel...

  11. Repeated mild traumatic brain injury can cause acute neurologic impairment without overt structural damage in juvenile rats.

    Directory of Open Access Journals (Sweden)

    Alicia Meconi

    Full Text Available Repeated concussion is becoming increasingly recognized as a serious public health concern around the world. Moreover, there is a greater awareness amongst health professionals of the potential for repeated pediatric concussions to detrimentally alter the structure and function of the developing brain. To better study this issue, we developed an awake closed head injury (ACHI model that enabled repeated concussions to be performed reliably and reproducibly in juvenile rats. A neurological assessment protocol (NAP score was generated immediately after each ACHI to help quantify the cumulative effects of repeated injury on level of consciousness, and basic motor and reflexive capacity. Here we show that we can produce a repeated ACHI (4 impacts in two days in both male and female juvenile rats without significant mortality or pain. We show that both single and repeated injuries produce acute neurological deficits resembling clinical concussion symptoms that can be quantified using the NAP score. Behavioural analyses indicate repeated ACHI acutely impaired spatial memory in the Barnes maze, and an interesting sex effect was revealed as memory impairment correlated moderately with poorer NAP score performance in a subset of females. These cognitive impairments occurred in the absence of motor impairments on the Rotarod, or emotional changes in the open field and elevated plus mazes. Cresyl violet histology and structural magnetic resonance imaging (MRI indicated that repeated ACHI did not produce significant structural damage. MRI also confirmed there was no volumetric loss in the cortex, hippocampus, or corpus callosum of animals at 1 or 7 days post-ACHI. Together these data indicate that the ACHI model can provide a reliable, high throughput means to study the effects of concussions in juvenile rats.

  12. Air Pollution and Forest Health: Establishing Cause and Effect in the Forest

    Directory of Open Access Journals (Sweden)

    William J. Manning

    2001-01-01

    Full Text Available I participated in a NATO Advanced Research Workshop titled “Effects of Air Pollution on Forest Health and Biodiversity in Forests of the Carpathian Mountains,” in Stara Lesna, Slovakia from May 22–26, 2001. Researchers from Canada, Czech Republic, Poland, Romania, Slovakia, Ukraine, and the U.S. met to present their results from a three-year cooperative study of tree health and air quality monitoring in forests of the Carpathian Mountains in Central Europe. Much of the work reported related to assessing the crown condition of trees in permanent plots in natural or managed (planted forests in the mountains. The endpoint was tree condition, with results extrapolated to the forests in the Carpathian range. From this I learned that, of the 50,000 trees evaluated, European beech (Fagus sylvatica was the most healthy, while Norway spruce (Picea abies (the principal forest tree and white fir (Abies alba sustained crown defoliation of up to 12.8%. The cause of this crown defoliation and tree decline was usually attributed to “air pollution” as a generic term and an automatic assumption. It is well known that deposition of heavy metals and acidic sulfur and nitrogen compounds can cause tree decline and predispose affected trees to bark beetles and climatic damage. Chemical analyses can also be done to detect metals and sulfur compounds in trees and soils. Sometimes these analyses were done, but most often the assumption was that crown defoliation was caused by air pollution. The assumption was that given sufficient exposure to high enough concentrations of toxic elements, sooner or later there will be a visible adverse response.

  13. Stigma as a Fundamental Cause of Population Health Inequalities

    Science.gov (United States)

    Phelan, Jo C.

    2013-01-01

    Bodies of research pertaining to specific stigmatized statuses have typically developed in separate domains and have focused on single outcomes at 1 level of analysis, thereby obscuring the full significance of stigma as a fundamental driver of population health. Here we provide illustrative evidence on the health consequences of stigma and present a conceptual framework describing the psychological and structural pathways through which stigma influences health. Because of its pervasiveness, its disruption of multiple life domains (e.g., resources, social relationships, and coping behaviors), and its corrosive impact on the health of populations, stigma should be considered alongside the other major organizing concepts for research on social determinants of population health. PMID:23488505

  14. The effect of urbanization in an arid region: Formation of a perched water table that causes environmental damages

    Science.gov (United States)

    Karnieli, A.; Issar, A.; Wolf, M.

    1984-03-01

    Construction in a new neighborhood in the israeli town of Dimona, situated in an arid region in the south of the country (150 mm average annual rainfall), resulted in a rise in groundwater levels during the subsequent rainy seasons This caused flooding of shelter basements, soil sliding, and sagging which permanently damaged walls and buildings The neighborhood had been built on continental sands and marls blanketed by loess, on a valley slope near a rocky anticlinal dip-slope Subsurface studies, using piezometer holes and groundwater analyses, revealed the presence of sand lenses alternating with plastic marls, which act as seasonal aquifers with perched water tables Groundwaters obtain high SO{4/-2} and Cl- corrosivity through contact with these nonflushed marls of the Neogene valley fill (Hazeva Formation) The reasons for the rising of groundwater were found to be (a) artificial interference with the natural (pre-construction) drainage system—interception of the hillside runoff by building plots, roads, etc, (b) partial denudation of the loess blanket, increasing the local infiltration and the build-up of local, perched water tables, and (c) corrosion of concrete and steel pipelines, as well as foundations, by prolonged contact with corrosive groundwater, resulting in haphazard but massive leakage Guidelines are proposed for an environmental improvement plan, which would include terracing and planting of the watershed above town to increase evapotranspiration, lowering of the water table by pumping, and diverting the water to suburban parks (groves of saltresistant trees), and replacement of steel and cement pipes by a non-corrodable plastic pipe system

  15. Vitamins as radioprotectors in vivo II. protection by vitamin A and soybean oil against radiation damage caused by internal radionuclides

    International Nuclear Information System (INIS)

    Harapanhalli, R.S.; Narra, V.R.; Yaghmai, V.; Azure, M.T.; Goddu, M.; Howell, R.W.; Rao, D.V.

    1994-01-01

    Tissue-incorporated radionuclides impart radiation energy over extended periods of time depending on their effective half-lives. The capacity of vitamin A dissolved in soybean oil to protect against the biological effects caused by internal radionuclides is investigated. The radiochemicals examined are DNA-binding 125 IdU, cytoplasmically localized H 125 IPDM and the α-particle emitter 210 Po citrate. As in our previous studies, spermatogenesis in mice is used as the experimental model and spermatogonial cell survival is the biological end point. Surprisingly, soybean oil itself provides substantial and equal protection against the Auger effect of 125 IdU, which is comparable to a high-LET radiation effect, as well as the low-LET effects of H 125 IPDM, the dose modification factors (DMFs) being 3.6 ± 0.9 (SEM) and 3.4 ± 0.9, respectively. The protection afforded by the oil against the effects of 5.3 MeV α particles emitted by 210Po is also significant (DMF = 2.2 ± 0.4). The presence of vitamin A in the oil further enhanced the radioprotection against the effect of 125 IdU (DMF = 4.8 ± 1.3) and H 125 IKPDM (DMF = 5.1 ± 0.6); however, no enhancement is provided against the effects of α particles. These interesting results with soybean oil and vitamin A, together with data on the subcellular distribution of the protectors, provide clues regarding the mechanistic aspects of the protection. In addition, the data for vitamin A reaffirm our earlier conclusion that the mechanism by which DNA-bound Auger emitters impart biological damage is primarily indirect in nature. 29 refs., 7 figs., 2 tabs

  16. Detection of damaged areas caused by the oil extraction in a steppe region using winter landsat imagery

    Science.gov (United States)

    Mjachina, Ksenya; Hu, Zhiyong; Chibilyev, Alexander

    2018-01-01

    Oil production in a steppe region disturbs the landscape and damages the steppe ecosystem. The objective of this research was to detect areas damaged by oil production in an oil field within the Russian Volga-Ural steppe region using winter Landsat imagery. We developed a practicable and effective approach using winter snow season multispectral Landsat satellite imagery. To this end, we applied seven algorithms of spectral or texture-based transformation: K-means, maximum likelihood estimation, topsoil grain size index, soil brightness, normalized differential snow index, tasselled cap, and co-occurrence measures. The co-occurrence texture measure variance shows the optimal result of identifying damaged areas. The unique feature of our method is that it can differentiate damaged areas from the bare soil of cropland within a cold steppe region where the area damaged by oil production is mixed with bare (fallow) croplands that have a polygonal shape similar to well pads. Such similarities can lead to confusion in object-based classification. Using the co-occurrence measures, we found that from 1988 to 2015, damaged area is nearly three times as big in the peak period of the oil field development (2001 and 2009) as in 1988. Landscape fragmentation also peaked in 2001 and 2009. Our approach for this project is useful and cost effective regular monitoring of damages from oil production for both the Volga-Ural steppe region and other cold steppe regions.

  17. Perceived Health System Causes of Obstetric Fistula from Accounts ...

    African Journals Online (AJOL)

    AJRH Managing Editor

    of Affected Women in Rural Tanzania: A Qualitative Study. 1*. Lilian T. .... achieved after 16 interviews, where answers from women .... delivery is crucial for safety of the future mothers and their ..... among obstetric care givers in public health.

  18. Effect of Caffeic Acid Phenethyl Ester on Vascular Damage Caused by Consumption of High Fructose Corn Syrup in Rats.

    Science.gov (United States)

    Gun, Aburrahman; Ozer, Mehmet Kaya; Bilgic, Sedat; Kocaman, Nevin; Ozan, Gonca

    2016-01-01

    Fructose corn syrup is cheap sweetener and prolongs the shelf life of products, but fructose intake causes hyperinsulinemia, hypertriglyceridemia, and hypertension. All of them are referred to as metabolic syndrome and they are risk factors for cardiovascular diseases. Hence, the harmful effects of increased fructose intake on health and their prevention should take greater consideration. Caffeic Acid Phenethyl Ester (CAPE) has beneficial effects on metabolic syndrome and vascular function which is important in the prevention of cardiovascular disease. However, there are no known studies about the effect of CAPE on fructose-induced vascular dysfunction. In this study, we examined the effect of CAPE on vascular dysfunction due to high fructose corn syrup (HFCS). HFCS (6 weeks, 30% fed with drinking water) caused vascular dysfunction, but treatment with CAPE (50 micromol/kg i.p. for the last two weeks) effectively restored this problem. Additionally, hypertension in HFCS-fed rats was also decreased in CAPE supplemented rats. CAPE supplements lowered HFCS consumption-induced raise in blood glucose, homocysteine, and cholesterol levels. The aorta tissue endothelial nitric oxide synthase (eNOS) production was decreased in rats given HFCS and in contrast CAPE supplementation efficiently increased its production. The presented results showed that HFCS-induced cardiovascular abnormalities could be prevented by CAPE treatment.

  19. Effect of Caffeic Acid Phenethyl Ester on Vascular Damage Caused by Consumption of High Fructose Corn Syrup in Rats

    Directory of Open Access Journals (Sweden)

    Aburrahman Gun

    2016-01-01

    Full Text Available Fructose corn syrup is cheap sweetener and prolongs the shelf life of products, but fructose intake causes hyperinsulinemia, hypertriglyceridemia, and hypertension. All of them are referred to as metabolic syndrome and they are risk factors for cardiovascular diseases. Hence, the harmful effects of increased fructose intake on health and their prevention should take greater consideration. Caffeic Acid Phenethyl Ester (CAPE has beneficial effects on metabolic syndrome and vascular function which is important in the prevention of cardiovascular disease. However, there are no known studies about the effect of CAPE on fructose-induced vascular dysfunction. In this study, we examined the effect of CAPE on vascular dysfunction due to high fructose corn syrup (HFCS. HFCS (6 weeks, 30% fed with drinking water caused vascular dysfunction, but treatment with CAPE (50 micromol/kg i.p. for the last two weeks effectively restored this problem. Additionally, hypertension in HFCS-fed rats was also decreased in CAPE supplemented rats. CAPE supplements lowered HFCS consumption-induced raise in blood glucose, homocysteine, and cholesterol levels. The aorta tissue endothelial nitric oxide synthase (eNOS production was decreased in rats given HFCS and in contrast CAPE supplementation efficiently increased its production. The presented results showed that HFCS-induced cardiovascular abnormalities could be prevented by CAPE treatment.

  20. Changes in properties of DNA caused by gamma and ultraviolet radiation. Dependence of conformational changes on the chemical nature of the damage

    Energy Technology Data Exchange (ETDEWEB)

    Vorlickova, M; Palacek, E [Ceskoslovenska Akademie Ved, Brno. Biofysikalni Ustav

    1978-02-16

    Changes in the pulse-polarographic behaviour and circular dichroism spectra of DNA were investigated after gamma and ultraviolet irradiations and after degradation by DNAase I. It was found that moderate doses of radiation cause local conformational changes in the double helix which are dependent on the chemical nature of the damage. Only the accumulation of structural changes after high doses of the radiations or after extensive enzymic treatment may cause formation of single-standed regions in DNA.

  1. Economic models of compensation for damages caused by nuclear accidents: some lessons for the revision of the Paris and Vienna Conventions

    International Nuclear Information System (INIS)

    Faure, Michael G.

    1995-01-01

    Alternative systems of compensation for damages caused by nuclear accidents have been proposed. In respect, the question merits attention to whether these alternative models of compensation discussed in the economic literature could be implemented when discussing the revision of the Paris and Vienna Conventions. 55 refs., 1 tab

  2. DNA damage and oxidative stress in human liver cell L-02 caused by surface water extracts during drinking water treatment in a waterworks in China.

    Science.gov (United States)

    Xie, Shao-Hua; Liu, Ai-Lin; Chen, Yan-Yan; Zhang, Li; Zhang, Hui-Juan; Jin, Bang-Xiong; Lu, Wen-Hong; Li, Xiao-Yan; Lu, Wen-Qing

    2010-04-01

    Because of the daily and life-long exposure to disinfection by-products formed during drinking water treatment, potential adverse human health risk of drinking water disinfection is of great concern. Toxicological studies have shown that drinking water treatment increases the genotoxicity of surface water. Drinking water treatment is comprised of different potabilization steps, which greatly influence the levels of genotoxic products in the surface water and thus may alter the toxicity and genotoxicity of surface water. The aim of the present study was to understand the influence of specific steps on toxicity and genotoxicity during the treatment of surface water in a water treatment plant using liquid chlorine as the disinfectant in China. An integrated approach of the comet and oxidative stress assays was used in the study, and the results showed that both the prechlorination and postchlorination steps increased DNA damage and oxidative stress caused by water extracts in human derived L-02 cells while the tube settling and filtration steps had the opposite effect. This research also highlighted the usefulness of an integrated approach of the comet and oxidative stress assays in evaluating the genotoxicity of surface water during drinking water treatment. Copyright 2009 Wiley-Liss, Inc.

  3. The use of the DInSAR method in the monitoring of road damage caused by mining activities

    Science.gov (United States)

    Murdzek, Radosław; Malik, Hubert; Leśniak, Andrzej

    2018-04-01

    This paper reviews existing remote sensing methods of road damage detection and demonstrates the possibility of using DInSAR (Differential Interferometry SAR) method to identify endangered road sections. In this study two radar images collected by Sentinel-1 satellite have been used. Images were acquired with 24 days interval in 2015. The analysis allowed to estimate the scale of the post-mining deformation that occurred in Upper Silesia and to indicate areas where road infrastructure is particularly vulnerable to damage.

  4. Smoking is a cause of social inequality in health, but is social position is cause of smoking?

    DEFF Research Database (Denmark)

    Mortensen, Laust Hvas

    2011-01-01

    (for an elaborate example of these misconceptions, see e.g. Mortensen et al.).3 I think this highlights the need for great caution when we apply prescriptive interpretations to descriptive studies. Smoking is a cause of social inequality in health: If smoking was eliminated social differences would......: 28 year cohort study. BMJ 2011; 342:d3785. (2) Mackenbach JP. What would happen to health inequalities if smoking were eliminated? BMJ 2011; 342:d3460. (3) Mortensen LH, Diderichsen F, Smith GD, Andersen AM. The social gradient in birthweight at term: quantification of the mediating role of maternal......The paper by Hart and colleagues describes occupational class differences in cause specific mortality among women who had never smoked.1 In the accompanying commentary smoking is discussed as if it was a mediator of the relationship between social position and health.2 But the uptake of smoking...

  5. Application of routine MRI and 1H-MRS in evaluating the central neurological damages caused by occupational manganese exposure

    International Nuclear Information System (INIS)

    Li Xiangrong; Long Liling; Jiang Muliang

    2010-01-01

    .051±0.024), (0.047± 0.018), (0.043±0.020) μg/ml respectively, which was not significantly different (F=0.623, P= 0.541) and did not exceed the upper limit of normal reference value ( 0.05). No obvious changes of the PI and NAA/Cr were found in the 8 manganese exposed workers after 1 year follow-up. Conclusion: Manganese exposure could lead to the high intensity signal on T 1 WI, therefore the increased PI may be the biomarkers of central nerve system damages caused by the occupational manganese exposure. (authors)

  6. SUM06 Index for Damage to Flora from Ozone

    Data.gov (United States)

    U.S. Environmental Protection Agency — In addition to health effects in humans, Ozone exposure also causes damage to plants. One index used in calculating the potential damage to plants from Ozone...

  7. Estimation of health damage due to emission of air pollutants by cars: the canyon effect

    Energy Technology Data Exchange (ETDEWEB)

    Spadaro, J.V. [Ecole des Mines, Centre d' Energetique, Paris, 75 (France); Rabl, A.

    1999-07-01

    Since current epidemiological evidence suggests that air pollution has harmful effects even at typical ambient concentrations and the dispersion is significant over hundreds to thousands of km, the estimation of total health damage involves consideration of local and regional effects. In recent years, several estimates have been published of health damage due to air pollution from cars, in particular by Delucchi et al of UC Davis and by the ExternE Project of the European Commission. To capture the geographic extent of pollutant dispersion, local and regional models have been used in combination. The present paper addresses a potentially significant contribution of the total damage, not yet taken into account in these studies: the increased concentration of pollutants inside urban street canyons. This canyon effect is appreciable only for primary pollutants, the time constants for the formation of secondary pollutants being long compared to the residence time in the canyon. We assumed linearity of incremental health impact with incremental concentration, in view of the lack of epidemiological evidence for no-effect thresholds or significant deviations from linearity at typical ambient concentrations; therefore, only long term average concentrations matter. We use the FLUENT software to model the dispersion inside a street canyon for a wide range of rectangular geometries and wind velocities. Our results suggest that the canyon effect is of marginal significance for total damages, the contribution of the canyon effect being roughly 10 to 20% of the total. The relative importance of the canyon effect is, of course, highly variable with local conditions; it could be much smaller but it is unlikely to add more than 100% to the flat terrain estimate. (Author)

  8. Health Alert: Adrenal Crisis Causes Death in Some People Who Were Treated with hGH

    Science.gov (United States)

    ... Were Treated with hGH Health Alert: Adrenal Crisis Causes Death in Some People Who Were Treated with hGH ... Adrenal crisis is a serious condition that can cause death in people who lack the pituitary hormone ACTH. ...

  9. Artificial immune pattern recognition for damage detection in structural health monitoring sensor networks

    Science.gov (United States)

    Chen, Bo; Zang, Chuanzhi

    2009-03-01

    This paper presents an artificial immune pattern recognition (AIPR) approach for the damage detection and classification in structures. An AIPR-based Structure Damage Classifier (AIPR-SDC) has been developed by mimicking immune recognition and learning mechanisms. The structure damage patterns are represented by feature vectors that are extracted from the structure's dynamic response measurements. The training process is designed based on the clonal selection principle in the immune system. The selective and adaptive features of the clonal selection algorithm allow the classifier to generate recognition feature vectors that are able to match the training data. In addition, the immune learning algorithm can learn and remember various data patterns by generating a set of memory cells that contains representative feature vectors for each class (pattern). The performance of the presented structure damage classifier has been validated using a benchmark structure proposed by the IASC-ASCE (International Association for Structural Control - American Society of Civil Engineers) Structural Health Monitoring Task Group. The validation results show a better classification success rate comparing to some of other classification algorithms.

  10. Damage Detection Sensitivity of a Vehicle-based Bridge Health Monitoring System

    Science.gov (United States)

    Miyamoto, Ayaho; Yabe, Akito; Lúcio, Válter J. G.

    2017-05-01

    As one solution to the problem for condition assessment of existing short and medium span (10-30m) reinforced/prestressed concrete bridges, a new monitoring method using a public bus as part of a public transit system (called “Bus monitoring system”) was proposed, along with safety indices, namely, “characteristic deflection”, which is relatively free from the influence of dynamic disturbances due to such factors as the roughness of the road surface, and a structural anomaly parameter. In this study, to evaluate the practicality of the newly developed bus monitoring system, it has been field-tested over a period of about four years by using an in-service fixed-route bus operating on a bus route in the city of Ube, Yamaguchi Prefecture, Japan. In here, although there are some useful monitoring methods for short and medium span bridges based on the qualitative or quantitative information, the sensitivity of damage detection was newly discussed for safety assessment based on long term health monitoring data. The verification results thus obtained are also described in this paper, and also evaluates the sensitivity of the “characteristic deflection”, which is a bridge (health) condition indicator used by the bus monitoring system, in damage detection. Sensitivity of “characteristic deflection” is verified by introducing artificial damage into a bridge that has ended its service life and is awaiting removal. Furthermore, the sensitivity of “characteristic deflection” is verified by 3D FEM analysis.

  11. Electricity and risk of public health center had measles vaccine damage in Indonesia

    Directory of Open Access Journals (Sweden)

    Anggita Bunga Anggraini

    2016-03-01

    related to PHC hadmeasles damage vaccines.Methods: The analysis used a part of the data of Research Health Facilities (Rifaskes in 2011. The Rifaskeswas conducted in all health centers in all (33 provinces in Indonesia. Furthermore, this analysis uses dataonly health center in the province who have measles immunization coverage the national prevalence rate(81.6% or more, and health centers that have measles prevalence rate above the national prevalence rate(1.18% or more. Statistical data analysis performed using logistic regression analysis to determine someof the risk factors related to the health center had has measles vaccine damaged.Results: A number of 7 provinces (Riau, Jakarta, West Nusa Tenggara, East Nusa Tenggara, CentralSulawesi, South Sulawesi, Gorontalo with 1259 PHC met the inclusion criteria. Health centers locatedin rural areas compared with urban areas had 3.4-fold risk of a PHC that had measles damage vaccines[adjusted odds ratio (ORa = 3.37; 95% confidence interval (CI = 1.34 - 8.26]. Furthermore, the healthcenter with the availability of the electricity for less than 24 hours compared with available 24 hours had2.1-fold risk of PHC that had measles damage vaccines (ORa = 2.10; 95% CI = 1.02 - 4.33.Conclusion: Public health center in rural areas, or did not have not have commercial electric power, ordid not have the availability of day-to-day electricity less than 24 hours had more risk of a PHC that hadmeasles damage vaccines. (Health Science Journal of Indonesia 2015;6:116-20Keywords: measles, public health center, vaccine

  12. Short-term exposure to benzo[a]pyrene causes oxidative damage and affects haemolymph steroid levels in female crab Portunus trituberculatus

    International Nuclear Information System (INIS)

    Wen, Jianmin; Pan, Luqing

    2016-01-01

    Concern has increased regarding the adverse effects of polycyclic aromatic hydrocarbons (PAHs) on reproduction. However, limited information is available on the effects of PAHs in crustacean. In order to determine whether benzo[a]pyrene (B[a]P) could cause reproductive toxicity on the swimming crab Portunus trituberculatus, sexually mature female crabs were exposed to environmentally relevant concentrations of B[a]P (0, 0.1, 0.5 and 2.5 μg/L) for 10 days. B[a]P treatments resulted in high accumulation in ovary, and induced oxidative stress in a dose-dependent manner on ovary of crab. Furthermore, the haemolymph estradiol (E_2) and testosterone (T) levels were significantly decreased. Histological investigation also revealed the reproductive toxicity caused by B[a]P. The results demonstrated that waterborne exposure to B[a]P caused oxidative damage and disrupted sex steroids in female crab P. trituberculatus, ultimately resulting in histological alternation. - Highlights: • Waterborne exposure to B[a]P resulted in high accumulation in crab ovary. • The haemolymph 17β-estradiol and testosterone levels were significantly decreased by B[a]P exposure. • B[a]P induced oxidative damage in crab ovary. • B[a]P exposure caused histopathological alterations in crab ovary. - B[a]P disrupted sex steroids, caused oxidative damage and histological alternation in female crab P. trituberculatus.

  13. A global health problem caused by arsenic from natural sources

    Energy Technology Data Exchange (ETDEWEB)

    Ng, J.C.; Wang, J.P.; Shraim, A. [University of Queensland, Brisbane, Qld. (Australia). National Research Center for Environmental Toxicology

    2003-09-01

    Arsenic is a carcinogen to both humans and animals. Arsenicals have been associated with cancers of the skin, lung, and bladder. Clinical manifestations of chronic arsenic poisoning include non-cancer end point of hyper- and hypo-pigmentation, keratosis, hypertension, cardiovascular diseases and diabetes. Epidemiological evidence indicates that arsenic concentration exceeding 50 {mu}g l{sup -1} in the drinking water is not public health protective. The current WHO recommended guideline value for arsenic in drinking water is 10 {mu}g l{sup -1}, whereas many developing countries are still having a value of 50 {mu}g 1{sup -1}. It has been estimated that tens of millions of people are at risk exposing to excessive levels of arsenic from both contaminated water and arsenic-bearing coal from natural sources. The global health implication and possible intervention strategies were also discussed in this review article.

  14. Assessment of health risks caused by air pollutants

    International Nuclear Information System (INIS)

    Nilsson, Robert.

    1991-02-01

    This report is a support document to an other report from the Swedish Environmental Protection Agency 'Risk assessment - a research programme aimed at health risks from air pollution in the general environment', report 3890, 1991 and is a survey of the scientific 'state of the art' in the different parts of risk assessment. Furthermore certain proposals are made concerning the scientific content of the future research in this area. (au)

  15. Quantitative measurement of damage caused by 1064-nm wavelength optical trapping of Escherichia coli cells using on-chip single cell cultivation system

    International Nuclear Information System (INIS)

    Ayano, Satoru; Wakamoto, Yuichi; Yamashita, Shinobu; Yasuda, Kenji

    2006-01-01

    We quantitatively examined the possible damage to the growth and cell division ability of Escherichia coli caused by 1064-nm optical trapping. Using the synchronous behavior of two sister E. coli cells, the growth and interdivision times between those two cells, one of which was trapped by optical tweezers, the other was not irradiated, were compared using an on-chip single cell cultivation system. Cell growth stopped during the optical trapping period, even with the smallest irradiated power on the trapped cells. Moreover, the damage to the cell's growth and interdivision period was proportional to the total irradiated energy (work) on the cell, i.e., irradiation time multiplied by irradiation power. The division ability was more easily affected by a smaller energy, 0.36 J, which was 30% smaller than the energy that adversely affected growth, 0.54 J. The results indicate that the damage caused by optical trapping can be estimated from the total energy applied to cells, and furthermore, that the use of optical trapping for manipulating cells might cause damage to cell division and growth mechanisms, even at wavelengths under 1064 nm, if the total irradiation energy is excessive

  16. Unexpected damage and/or failures caused by creep below the limit temperature for creep design; Ovaentade krypskador och/eller haverier orsakade av krypmekanismer under graenstemperaturen

    Energy Technology Data Exchange (ETDEWEB)

    Storesund, Jan; Eklund, Anders; Taflin, Anders; Thunvik, Thomas

    2006-07-15

    Recently, several cases of cracking caused by creep have occurred in components operating at temperatures below the specified limit temperature for creep. Components operating below this limit temperature have not been designed with due regard to creep cracking and have accordingly not been subjected to inspection for creep damage. This work has surveyed the extent of these cases of creep damage by reviewing earlier failures and performed metallographic studies of damaged components and made parametric calculations of creep crack growth below the limit temperature. The following critical parameters have been determined for power plants: Creep damage below the transition temperature does not usually occur until operating times above 200.000 hours. Time to rupture differs from ordinary creep crack growth because these cracks have substantially longer incubation time of 20-30 years, with relative low creep deformation, and after that a rapid creep crack growth with only some few years to the creep rupture. Operation at 470-480 deg C, i.e. up to some 10 deg C below the transition temperature for a material like EN 13CrMo4-5, can be expected to result in severe creep damages comparable with ordinary creep failures at stressed locations. Operation at a temperature of 450-460 deg C can give rise to creep damage, however, this damage shows a more sparse occurrence. Creep damaged welds occurring below the limit temperature show cracks at the melting junction of the weld bead in opposite to ordinary creep damages. System stresses can also cause a more rapid crack growth. An international survey also shows that the variation of creep strength values between individual steel batches are just as wide as for ordinary creep. Based on this work, the following complementary recommendations can be issued: Elastic stress analysis (based on expansion calculations) can also be recommended for the identification of areas with intensified stresses. One should also perform a complete

  17. [Factors causing damage and destruction of beta-cells of the islets of Langerhans in the pancreas].

    Science.gov (United States)

    Anděl, Michal; Němcová, Vlasta; Pavlíková, Nela; Urbanová, Jana; Cecháková, Marie; Havlová, Andrea; Straková, Radka; Večeřová, Livia; Mandys, Václav; Kovář, Jan; Heneberg, Petr; Trnka, Jan; Polák, Jan

    2014-09-01

    Insulin secretion in patients with manifested diabetes mellitus tends to disappear months to decades after the diagnosis, which is a clear sign of a gradual loss of pancreatic islet beta-cells. In our sample of 30 type 2 diabetic patients, whose disease manifested between 30 and 45 years of age, about a half have retained or even increased insulin secretion 30 years later, while the other half exhibit a much diminished or lost insulin secretion. Factors that can damage or destroy beta-cells can be divided into the following groups: Metabolic factors: hyperglycemia and glucotoxicity, lipotoxicity, hypoxia, reactive oxygen species; Pharmacological factors: antimicrobial medication pentamidine, SSRI antidepressants; Factors related to impaired insulin secretion: MODY type diabetes; Environmental toxic factors: rat poison Vacor, streptozotocin, polychlorinated and polybrominated hydrocarbons; Disorders of the exocrine pancreas: tumor infiltration, fibrous infiltration, chronic pancreatitis, cystic fibrosis; Infections, inflammation, autoimmunity, viral factors: Coxsackie viruses, H1N1 influenza, enteroviruses. We are currently working on finding other factors leading to beta-cell damage, studying their effect on apoptosis and necrosis and looking for possible protective factors to prevent this damage. We our increasing knowledge about the mechanisms of beta-cell damage and destruction we come ever closer to suggest measures for their prevention. In this review we offer a brief and simplified summary of some of the findings related to this area.Key words: pancreatic islet beta-cells of Langerhans - factors damaging or destroying beta-cells - insulin secretion.

  18. Morphology of the primary damage caused by the argon-ion laser to the iris of the pigmented rabbit

    International Nuclear Information System (INIS)

    Huber, G.K.; Zypen, E. van der; Frankhauser, F.

    1979-01-01

    The effect of the argon-ion laser upon the iris of the pigmented rabbit were analysed by ultrastructural methods. Apart from the physical parameters of the energy source, the damage strongly depends on the concentration, location, and distribution of the iris pigment. The irradiation of the iris results in the formation of a crater. Depending on the distance of the epicentre of the impact, various degrees of ultrastructural damage are observed. The region immediately adjacent to the crater lumen at a revealing distance of 25 μm consists of homogenous masses, revealing a vacuolar structure. As the only residuals of destroyed cells, melanin granules are observed within the homogenous masses. Destruction of the collagen fibrils and their disintegration into subfibrils with elimination of all cell compartments is found in an area ranging from 25 μm to 300 μm from the wall of the crater. Damage to the chromatin structure is visible up to a distance of 300 μm to 375 μm from the wall of the crater. Characterised by an invasion of macrophages into the damaged area, the cleaning phase starts 24 h after irradiation. The results of this experiment indicate that because of the great energy dose required for man with the inherent widespread tissue damage and low probability of a lasting iridectomy, the cw argon-ion laser appears to be an unsuitable energy source for clinical iridectomy. (orig./AJ) 891 AJ/orig.- 892 MKO [de

  19. First estimates of the potential cost and cost saving of protecting childhood hearing from damage caused by congenital CMV infection.

    Science.gov (United States)

    Williams, Eleri J; Gray, Joanne; Luck, Suzanne; Atkinson, Claire; Embleton, Nicholas D; Kadambari, Seilesh; Davis, Adrian; Griffiths, Paul; Sharland, Mike; Berrington, Janet E; Clark, Julia E

    2015-11-01

    Congenital cytomegalovirus (cCMV) is an important cause of childhood deafness, which is modifiable if diagnosed within the first month of life. Targeted screening of infants who do not pass their newborn hearing screening tests in England is a feasible approach to identify and treat cases to improve hearing outcome. To conduct a cost analysis of targeted screening and subsequent treatment for cCMV-related sensorineural hearing loss (SNHL) in an, otherwise, asymptomatic infant, from the perspective of the UK National Health Service (NHS). Using data from the newborn hearing screening programme (NHSP) in England and a recent study of targeted screening for cCMV using salivary swabs within the NHSP, we estimate the cost (in UK pounds (£)) to the NHS. The cost of screening (time, swabs and PCR), assessing, treating and following up cases is calculated. The cost per case of preventing hearing deterioration secondary to cCMV with targeted screening is calculated. The cost of identifying, assessing and treating a case of cCMV-related SNHL through targeted cCMV screening is estimated to be £6683. The cost of improving hearing outcome for an infant with cCMV-related SNHL through targeted screening and treatment is estimated at £14 202. The costs of targeted screening for cCMV using salivary swabs integrated within NHSP resulted in an estimate of cost per case that compares favourably with other screening programmes. This could be used in future studies to estimate the full economic value in terms of incremental costs and incremental health benefits. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  20. Microplastics cause neurotoxicity, oxidative damage and energy-related changes and interact with the bioaccumulation of mercury in the European seabass, Dicentrarchus labrax (Linnaeus, 1758).

    Science.gov (United States)

    Barboza, Luís Gabriel Antão; Vieira, Luís Russo; Branco, Vasco; Figueiredo, Neusa; Carvalho, Felix; Carvalho, Cristina; Guilhermino, Lúcia

    2018-02-01

    Microplastics pollution is a global paradigm that raises concern in relation to environmental and human health. This study investigated toxic effects of microplastics and mercury in the European seabass (Dicentrarchus labrax), a marine fish widely used as food for humans. A short-term (96 h) laboratory bioassay was done by exposing juvenile fish to microplastics (0.26 and 0.69 mg/L), mercury (0.010 and 0.016 mg/L) and binary mixtures of the two substances using the same concentrations, through test media. Microplastics alone and mercury alone caused neurotoxicity through acetylcholinesterase (AChE) inhibition, increased lipid oxidation (LPO) in brain and muscle, and changed the activities of the energy-related enzymes lactate dehydrogenase (LDH) and isocitrate dehydrogenase (IDH). All the mixtures caused significant inhibition of brain AChE activity (64-76%), and significant increase of LPO levels in brain (2.9-3.4 fold) and muscle (2.2-2.9 fold) but not in a concentration-dependent manner; mixtures containing low and high concentrations of microplastics caused different effects on IDH and LDH activity. Mercury was found to accumulate in the brain and muscle, with bioaccumulation factors of 4-7 and 25-40, respectively. Moreover, in the analysis of mercury concentrations in both tissues, a significant interaction between mercury and microplastics was found. The decay of mercury in the water increased with microplastics concentration, and was higher in the presence of fish than in their absence. Overall, these results indicate that: microplastics influence the bioaccumulation of mercury by D. labrax juveniles; microplastics, mercury and their mixtures (ppb range concentrations) cause neurotoxicity, oxidative stress and damage, and changes in the activities of energy-related enzymes in juveniles of this species; mixtures with the lowest and highest concentrations of their components induced different effects on some biomarkers. These findings and other published

  1. Radiation, waves, fields. Causes and effects on environment and health

    International Nuclear Information System (INIS)

    Leitgeb, N.

    1990-01-01

    The book discusses static electricity, alternating electric fields, magnetostatic fields, alternating magnetic fields, electromagnetic radiation, optical and ionizing radiation and their hazards and health effects. Each chapter presents basic physical and biological concepts and describes the common radiation sources and their biological effects. Each chapter also contains hints for everyday behaviour as well as in-depth information an specific scientific approaches for assessing biological effects; the latter are addressed to all expert readers working in these fields. There is a special chapter on the problem of so-called 'terrestrial radiation'. (orig.) With 88 figs., 31 tabs [de

  2. Optical damage in reduced Z-cut LiNbO3 crystals caused by longitudinal photovoltaic and pyroelectric effects

    International Nuclear Information System (INIS)

    Kostritskii, S. M.; Aillerie, M.

    2012-01-01

    The marked optical damage was observed in thin Z-cut plates of the deeply reduced nominally pure LiNbO 3 crystals, when a 514.5-nm-laser beam with ordinary polarization was focused on the ±Z face. The longitudinal photovoltaic and pyroelectric effects are shown to be responsible for most of the important peculiarities of the optical damage dynamics. The anisotropy in the behavior between the +Z and -Z faces has been explained by interference of the different kinds of pyroelectric and photovoltaic effects to the space-charge field with an altering relative sign.

  3. Intangible asset valuation, damages, and transfer price analyses in the health care industry.

    Science.gov (United States)

    Reilly, Robert F

    2010-01-01

    Most health care industry participants own and operate intangible assets. These intangible assets can be industry-specific (e.g., patient charts and records, certificates of need, professional and other licenses), or they can be general commercial intangible assets (e.g., trademarks, systems and procedures, an assembled workforce). Many industry participants have valued their intangible assets for financial accounting or other purposes. This article summarizes the intangible assets that are common to health care industry participants. This article describes the different types of intangible asset analyses (including valuation, transfer price, damages estimates, etc.), and explains the many different transaction, accounting, taxation, regulatory, litigation, and other reasons why industry participants may wish to value (or otherwise analyze) health care intangible assets.

  4. Dissociation of DNA damage and mitochondrial injury caused by hydrogen peroxide in SV-40 transformed lung epithelial cells

    Directory of Open Access Journals (Sweden)

    Adcock Ian M

    2002-11-01

    Full Text Available Abstract Background Since lung epithelial cells are constantly being exposed to reactive oxygen intermediates (ROIs, the alveolar surface is a major site of oxidative stress, and each cell type may respond differently to oxidative stress. We compared the extent of oxidative DNA damage with that of mitochondrial injury in lung epithelial cells at the single cell level. Result DNA damage and mitochondrial injury were measured after oxidative stress in the SV-40 transformed lung epithelial cell line challenged with hydrogen peroxide (H2O2. Single cell analysis of DNA damage was determined by assessing the number of 8-oxo-2-deoxyguanosine (8-oxo-dG positive cells, a marker of DNA modification, and the length of a comet tail. Mitochondrial membrane potential, ΔΨm, was determined using JC-1. A 1 h pulse of H2O2 induced small amounts of apoptosis (3%. 8-oxo-dG-positive cells and the length of the comet tail increased within 1 h of exposure to H2O2. The number of cells with reduced ΔΨm increased after the addition of H2O2 in a concentration-dependent manner. In spite of a continual loss of ΔΨm, DNA fragmentation was reduced 2 h after exposure to H2O2. Conclusion The data suggest that SV-40 transformed lung epithelial cells are resistant to oxidative stress, showing that DNA damage can be dissociated from mitochondrial injury.

  5. Comparison of cotton square and boll damage and resulting lint and seed loss caused by verde plant bug, Creontiades signatus

    Science.gov (United States)

    Retention of bolls and squares (referred to as fruit retention), boll damage, and resulting cotton lint and seed weight loss were assessed when two (2010) and three (2011) age classes of sympodial fruiting branches with different ages of squares and bolls where exposed to verde plant bug, Creontiade...

  6. Susceptibility of sweet and sour cherry cultivars/genotypes to feeding damage caused by Bryobia rubrioculus (Acari: Tetranychidae)

    Czech Academy of Sciences Publication Activity Database

    Honarparvar, N.; Khanjani, M.; Zemek, Rostislav; Bouzari, N.

    2018-01-01

    Roč. 23, č. 1 (2018), s. 78-90 ISSN 1362-1971 Institutional support: RVO:60077344 Keywords : Prunus * brown mite * fee ding damage Subject RIV: GF - Plant Pathology, Vermin, Weed, Plant Protection OBOR OECD: Agronomy, plant breeding and plant protection Impact factor: 1.467, year: 2016

  7. Intermittent hypoxia causes histological kidney damage and increases growth factor expression in a mouse model of obstructive sleep apnea.

    Directory of Open Access Journals (Sweden)

    Bisher Abuyassin

    Full Text Available Epidemiological studies demonstrate an association between obstructive sleep apnea (OSA and accelerated loss of kidney function. It is unclear whether the decline in function is due to OSA per se or to other confounding factors such as obesity. In addition, the structural kidney abnormalities associated with OSA are unclear. The objective of this study was to determine whether intermittent hypoxia (IH, a key pathological feature of OSA, induces renal histopathological damage using a mouse model. Ten 8-week old wild-type male CB57BL/6 mice were randomly assigned to receive either IH or intermittent air (IA for 60 days. After euthanasia, one kidney per animal was paraformaldehyde-fixed and then sectioned for histopathological and immunohistochemical analysis. Measurements of glomerular hypertrophy and mesangial matrix expansion were made in periodic acid-Schiff stained kidney sections, while glomerular transforming growth factor-β1 (TGF-β1, connective tissue growth factor (CTGF and vascular endothelial growth factor-A (VEGF-A proteins were semi-quantified by immunohistochemistry. The antigen-antibody reaction was detected by 3,3'-diaminobenzidine chromogen where the color intensity semi-quantified glomerular protein expression. To enhance the accuracy of protein semi-quantification, the percentage of only highly-positive staining was used for analysis. Levels of TGF-β, CTGF and VEGF-A proteins in the kidney cortex were further quantified by western blotting. Cellular apoptosis was also investigated by measuring cortical antiapoptotic B-cell lymphoma 2 (Bcl-2 and apoptotic Bcl-2-associated X (Bax proteins by western blotting. Further investigation of cellular apoptosis was carried out by fluorometric terminal deoxynucleotidyl transferase (TdT dUTP Nick-End Labeling (TUNEL staining. Finally, the levels of serum creatinine and 24-hour urinary albumin were measured as a general index of renal function. Our results indicate that mice exposed to IH

  8. Intermittent hypoxia causes histological kidney damage and increases growth factor expression in a mouse model of obstructive sleep apnea.

    Science.gov (United States)

    Abuyassin, Bisher; Badran, Mohammad; Ayas, Najib T; Laher, Ismail

    2018-01-01

    Epidemiological studies demonstrate an association between obstructive sleep apnea (OSA) and accelerated loss of kidney function. It is unclear whether the decline in function is due to OSA per se or to other confounding factors such as obesity. In addition, the structural kidney abnormalities associated with OSA are unclear. The objective of this study was to determine whether intermittent hypoxia (IH), a key pathological feature of OSA, induces renal histopathological damage using a mouse model. Ten 8-week old wild-type male CB57BL/6 mice were randomly assigned to receive either IH or intermittent air (IA) for 60 days. After euthanasia, one kidney per animal was paraformaldehyde-fixed and then sectioned for histopathological and immunohistochemical analysis. Measurements of glomerular hypertrophy and mesangial matrix expansion were made in periodic acid-Schiff stained kidney sections, while glomerular transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF) and vascular endothelial growth factor-A (VEGF-A) proteins were semi-quantified by immunohistochemistry. The antigen-antibody reaction was detected by 3,3'-diaminobenzidine chromogen where the color intensity semi-quantified glomerular protein expression. To enhance the accuracy of protein semi-quantification, the percentage of only highly-positive staining was used for analysis. Levels of TGF-β, CTGF and VEGF-A proteins in the kidney cortex were further quantified by western blotting. Cellular apoptosis was also investigated by measuring cortical antiapoptotic B-cell lymphoma 2 (Bcl-2) and apoptotic Bcl-2-associated X (Bax) proteins by western blotting. Further investigation of cellular apoptosis was carried out by fluorometric terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) staining. Finally, the levels of serum creatinine and 24-hour urinary albumin were measured as a general index of renal function. Our results indicate that mice exposed to IH have an

  9. A framework for data compression and damage detection in structural health monitoring applied on a laboratory three-story structure

    Directory of Open Access Journals (Sweden)

    Manoel Afonso Pereira de Lima

    2016-09-01

    Full Text Available Structural Health Monitoring (SHM is an important technique used to preserve many types of structures in the short and long run, using sensor networks to continuously gather the desired data. However, this causes a strong impact in the data size to be stored and processed. A common solution to this is using compression algorithms, where the level of data compression should be adequate enough to allow the correct damage identification. In this work, we use the data sets from a laboratory three-story structure to evaluate the performance of common compression algorithms which, then, are combined with damage detection algorithms used in SHM. We also analyze how the use of Independent Component Analysis, a common technique to reduce noise in raw data, can assist the detection performance. The results showed that Piecewise Linear Histogram combined with Nonlinear PCA have the best trade-off between compression and detection for small error thresholds while Adaptive PCA with Principal Component Analysis perform better with higher values.

  10. Viral Causes of Hearing Loss: A Review for Hearing Health Professionals

    Science.gov (United States)

    Cohen, Brandon E.; Durstenfeld, Anne

    2014-01-01

    A number of viral infections can cause hearing loss. Hearing loss induced by these viruses can be congenital or acquired, unilateral or bilateral. Certain viral infections can directly damage inner ear structures, others can induce inflammatory responses which then cause this damage, and still others can increase susceptibility or bacterial or fungal infection, leading to hearing loss. Typically, virus-induced hearing loss is sensorineural, although conductive and mixed hearing losses can be seen following infection with certain viruses. Occasionally, recovery of hearing after these infections can occur spontaneously. Most importantly, some of these viral infections can be prevented or treated. For many of these viruses, guidelines for their treatment or prevention have recently been revised. In this review, we outline many of the viruses that cause hearing loss, their epidemiology, course, prevention, and treatment. PMID:25080364

  11. A time reversal damage imaging method for structure health monitoring using Lamb waves

    International Nuclear Information System (INIS)

    Zhang Hai-Yan; Cao Ya-Ping; Sun Xiu-Li; Chen Xian-Hua; Yu Jian-Bo

    2010-01-01

    This paper investigates the Lamb wave imaging method combining time reversal for health monitoring of a metallic plate structure. The temporal focusing effect of the time reversal Lamb waves is investigated theoretically. It demonstrates that the focusing effect is related to the frequency dependency of the time reversal operation. Numerical simulations are conducted to study the time reversal behaviour of Lamb wave modes under broadband and narrowband excitations. The results show that the reconstructed time reversed wave exhibits close similarity to the reversed narrowband tone burst signal validating the theoretical model. To enhance the similarity, the cycle number of the excited signal should be increased. Experiments combining finite element model are then conducted to study the imaging method in the presence of damage like hole in the plate structure. In this work, the time reversal technique is used for the recompression of Lamb wave signals. Damage imaging results with time reversal using broadband and narrowband excitations are compared to those without time reversal. It suggests that the narrowband excitation combined time reversal can locate and determine the size of structural damage more precisely, but the cycle number of the excited signal should be chosen reasonably

  12. Analysis of the Causes and Recommendations on Elimination of Biological Damage of Structures During the Repair and Reconstruction of the State Biological Museum in Moscow

    Directory of Open Access Journals (Sweden)

    Kamskov Viktor

    2017-01-01

    Full Text Available The article presents the results of mycological research on buildings of the State Biological Museum located in Moscow. Over time, the building maintenance conditions have worsened, in particular because of construction of high-rise buildings in the immediate vicinity of the museum, as well as construction of a greenhouse above the underground passage tunnel between buildings 1 and 2. Over the years, the temperature gradients, high humidity, wear and damage of wall waterproofing and foundations have caused leaks in the underpass tunnel and the biological corrosion of stone, wood and metal structures in indoor exhibition halls. In this connection, part of the survey was to determine the types and size of biological lesions in structures, determination of the causes of biological damage, and the development of measures to eliminate the mycological problems during repair and reconstruction works in the museum.

  13. Enterococcus faecalis Infection Causes Inflammation, Intracellular Oxphos-Independent ROS Production, and DNA Damage in Human Gastric Cancer Cells

    DEFF Research Database (Denmark)

    Strickertsson, Jesper A. B; Desler, Claus; Martin-Bertelsen, Tomas

    2013-01-01

    therefore wanted to study the impact of E. faecalis infection on inflammatory response, reactive oxygen species (ROS) formation, mitochondrial respiration, and mitochondrial genetic stability in gastric mucosal cells. Methods To separate the changes induced by bacteria from those of the inflammatory cells...... intracellular ROS production through a pathway independent of oxidative phosphorylation (oxphos). Furthermore, E. faecalis infection induced mitochondrial DNA instability. Following infection, genes coding for inflammatory response proteins were transcriptionally up-regulated while DNA damage repair and cell...... cycle control genes were down-regulated. Cell growth slowed down when infected with viable E. faecalis and responded in a dose dependent manner to E. faecalis lysate. Conclusions Infection by E. faecalis induced an oxphos-independent intracellular ROS response and damaged the mitochondrial genome...

  14. Evaluation of the Toxicity, AChE Activity and DNA Damage Caused by Imidacloprid on Earthworms, Eisenia fetida.

    Science.gov (United States)

    Wang, Kai; Qi, Suzhen; Mu, Xiyan; Chai, Tingting; Yang, Yang; Wang, Dandan; Li, Dongzhi; Che, Wunan; Wang, Chengju

    2015-10-01

    Imidacloprid is a well-known pesticide and it is timely to evaluate its toxicity to earthworms (Eisenia fetida). In the present study, the effect of imidacloprid on reproduction, growth, acetylcholinesterase (AChE) and DNA damage in earthworms was assessed using an artificial soil medium. The median lethal concentration (LC50) and the median number of hatched cocoons (EC50) of imidacloprid to earthworms was 3.05 and 0.92 mg/kg respectively, the lowest observed effect concentration of imidacloprid about hatchability, growth, AChE activity and DNA damage was 0.02, 0.5, 0.1 and 0.5 mg/kg, respectively.

  15. Methylmercury Causes Blood-Brain Barrier Damage in Rats via Upregulation of Vascular Endothelial Growth Factor Expression.

    Directory of Open Access Journals (Sweden)

    Tetsuya Takahashi

    Full Text Available Clinical manifestations of methylmercury (MeHg intoxication include cerebellar ataxia, concentric constriction of visual fields, and sensory and auditory disturbances. The symptoms depend on the site of MeHg damage, such as the cerebellum and occipital lobes. However, the underlying mechanism of MeHg-induced tissue vulnerability remains to be elucidated. In the present study, we used a rat model of subacute MeHg intoxication to investigate possible MeHg-induced blood-brain barrier (BBB damage. The model was established by exposing the rats to 20-ppm MeHg for up to 4 weeks; the rats exhibited severe cerebellar pathological changes, although there were no significant differences in mercury content among the different brain regions. BBB damage in the cerebellum after MeHg exposure was confirmed based on extravasation of endogenous immunoglobulin G (IgG and decreased expression of rat endothelial cell antigen-1. Furthermore, expression of vascular endothelial growth factor (VEGF, a potent angiogenic growth factor, increased markedly in the cerebellum and mildly in the occipital lobe following MeHg exposure. VEGF expression was detected mainly in astrocytes of the BBB. Intravenous administration of anti-VEGF neutralizing antibody mildly reduced the rate of hind-limb crossing signs observed in MeHg-exposed rats. In conclusion, we demonstrated for the first time that MeHg induces BBB damage via upregulation of VEGF expression at the BBB in vivo. Further studies are required in order to determine whether treatment targeted at VEGF can ameliorate MeHg-induced toxicity.

  16. Significance of 8-oxoG in the spectrum of DNA damages caused by ionising radiation of different quality

    Czech Academy of Sciences Publication Activity Database

    Štěpán, Václav; Davídková, Marie

    2007-01-01

    Roč. 122, 1-4 (2007), s. 113-115 ISSN 0144-8420. [Symposium on Microdosimetry /14./. Venezia, 13.11.2005-18.11.2005] R&D Projects: GA AV ČR KJB4048401; GA ČR GA202/05/2728 Institutional research plan: CEZ:AV0Z10480505 Keywords : DNA damage * 8-oxoguanine * ionizing radiation * theoretical modeling Subject RIV: BO - Biophysics Impact factor: 0.528, year: 2007

  17. Health risk factors in lead polluted environment causing isthemic health disease

    International Nuclear Information System (INIS)

    Khnwal, S.; Rahman, K.U.

    2008-01-01

    Faisalabad is third most populous and industrial city, known as Manchester of Pakistan. Most of the people working in the industries of this city are exposed to highly polluted and toxic environment. Lead is a natural metal found in the environment and its contamination exceeds the range of normal limits by human activities causing a lot of health hazardous. An effort is made to assess the association of anemia and cholesterol with the development IHD among industrial workers who are exposed to the lead polluted environment. For this purpose the study was conducted during a period of one year (2006-7) and the respondents were the patients from industrial area coming to the hospitals visiting at DHQ Hospital Faisalabad. Only those patients were selected for this study who were diagnosed with clinical symptoms of lead toxicity. The demographic features of the respondents regarding their age, gender, marital status, family size, education, income, duration on job, working place and nature of work were considered. The data of this study was categorical nature and this measures the association among exposure to the environment with lead toxicity and causative risk factors i.e., cholesterol level, Hb level (anemia) causing ischemic heart disease (IHD) were studied. (author)

  18. Sensitivity of spiral ganglion neurons to damage caused by mobile phone electromagnetic radiation will increase in lipopolysaccharide-induced inflammation in vitro model.

    Science.gov (United States)

    Zuo, Wen-Qi; Hu, Yu-Juan; Yang, Yang; Zhao, Xue-Yan; Zhang, Yuan-Yuan; Kong, Wen; Kong, Wei-Jia

    2015-05-29

    With the increasing popularity of mobile phones, the potential hazards of radiofrequency electromagnetic radiation (RF-EMR) on the auditory system remain unclear. Apart from RF-EMR, humans are also exposed to various physical and chemical factors. We established a lipopolysaccharide (LPS)-induced inflammation in vitro model to investigate whether the possible sensitivity of spiral ganglion neurons to damage caused by mobile phone electromagnetic radiation (at specific absorption rates: 2, 4 W/kg) will increase. Spiral ganglion neurons (SGN) were obtained from neonatal (1- to 3-day-old) Sprague Dawley® (SD) rats. After the SGN were treated with different concentrations (0, 20, 40, 50, 100, 200, and 400 μg/ml) of LPS, the Cell Counting Kit-8 (CCK-8) and alkaline comet assay were used to quantify cellular activity and DNA damage, respectively. The SGN were treated with the moderate LPS concentrations before RF-EMR exposure. After 24 h intermittent exposure at an absorption rate of 2 and 4 W/kg, DNA damage was examined by alkaline comet assay, ultrastructure changes were detected by transmission electron microscopy, and expression of the autophagy markers LC3-II and Beclin1 were examined by immunofluorescence and confocal laser scanning microscopy. Reactive oxygen species (ROS) production was quantified by the dichlorofluorescin-diacetate assay. LPS (100 μg/ml) induced DNA damage and suppressed cellular activity (P 0.05); therefore, 40 μg/ml was used to pretreat the concentration before exposure to RF-EMR. RF-EMR could not directly induce DNA damage. However, the 4 W/kg combined with LPS (40 μg/ml) group showed mitochondria vacuoles, karyopyknosis, presence of lysosomes and autophagosome, and increasing expression of LC3-II and Beclin1. The ROS values significantly increased in the 4 W/kg exposure, 4 W/kg combined with LPS (40 μg/ml) exposure, and H2O2 groups (P spiral ganglion neurons, but it could cause the changes of cellular ultrastructure at special SAR 4

  19. An experimental demonstration of stem damage as a predictor of fire-caused mortality for ponderosa pine

    Science.gov (United States)

    van Mantgem, P.; Schwartz, M.

    2004-01-01

    We subjected 159 small ponderosa pine (Pinus ponderosa Dougl. ex P. & C. Laws.) to treatments designed to test the relative importance of stem damage as a predictor of postfire mortality. The treatments consisted of a group with the basal bark artificially thinned, a second group with fuels removed from the base of the stem, and an untreated control. Following prescribed burning, crown scorch severity was equivalent among the groups. Postfire mortality was significantly less frequent in the fuels removal group than in the bark removal and control groups. No model of mortality for the fuels removal group was possible, because dead trees constituted trees. Mortality in the bark removal group was best predicted by crown scorch and stem scorch severity, whereas death in the control group was predicted by crown scorch severity and bark thickness. The relative lack of mortality in the fuels removal group and the increased sensitivity to stem damage in the bark removal group suggest that stem damage is a critical determinant of postfire mortality for small ponderosa pine.

  20. Descriptive study of damage caused by the rhinoceros beetle, Oryctes agamemnon, and its influence on date palm oases of Rjim Maatoug, Tunisia.

    Science.gov (United States)

    Soltani, Rasmi; Lkbel, Chaieb; Habib Ben Hamouda, Med

    2008-01-01

    Oryctes agamemnon (Burmeister 1847) (Coleoptera, Scarabaeidae) was accidentally introduced in the southwestern oases of Tunisia (Tozeur) around 1980 and spread to the Rjim Maatoug region. In these areas O. agamemnon was specific to date palm trees causing severe damage that can result in potential danger due to collapse of the tree. This study was conducted from April 2004 to March 2006 in 4 sites in the region of Rjim Maatoug. Different levels of palm tree attack were determined, ovioposition sites were identified, and pest damage was described in detail to specify their relative importance and to indicate factors governing palm tree attack. Eggs were individually oviposited in the attacked parts. Dead parts of palm trees were the main target of O. agamemnon including the respiratory roots, tough, trunk bark, dry petiole and the periphery of the crown. The crown itself was not attacked. Feeding by larvae caused significant damage. The biggest danger occurred when heavy attacks of larvae invaded the respiratory roots at the level of the soil, and secondarily on the periphery of the crown, which can result in fungal diseases. Several cases of Deglet Nour date palm tree collapse were caused by this pest in Rjim Maatoug. Attacks on other parts of the tree were without danger for the palm tree. In the absence of pest management, application of a quarantine program combined with field cultivation techniques could help farmers significantly decrease attack of O. agamemnon on palm trees.

  1. Exploring causes and consequences of sex workers' psychological health: Implications for health care policy. A study conducted in Spain.

    Science.gov (United States)

    Picos, Andrés Palacios; González, Ruth Pinedo; de la Iglesia Gutiérrez, Myriam

    2018-03-22

    The aim of the researchers is to explore the causes and consequences of the psychological health of sex workers as well as provide an intervention model for the prevention of mental disorders in accordance with World Health Organization (WHO) levels. The study sample consisted of 146 sex workers from Spain. Loneliness and maltreatment have a negative influence on psychological health, while self-esteem has a protector role over psychological health. Psychological health has a positive impact on perceived quality of life and other health domains. On the contrary, psychological health has a negative impact on drug use and symptoms of anxiety. Data are discussed.

  2. A Water-Damaged Home and Health of Occupants: A Case Study

    International Nuclear Information System (INIS)

    Thrasher, J.D.; Gray, M.R.; Kilburn, K.H.; Kilburn, K.H.; Dennis, D.P.; Yu, A.

    2012-01-01

    A family of five and pet dog who rented a water-damaged home and developed multiple health problems. The home was analyzed for species of mold and bacteria. The diagnostics included MRI for chronic sinusitis with ENT and sinus surgery, and neurological testing for neuro cognitive deficits. Bulk samples from the home, tissue from the sinuses, urine, nasal secretions, placenta, umbilical cord, and breast milk were tested for the presence of trichothecene, aflatoxins, and Ochratoxin A. The family had the following diagnosed conditions: chronic sinusitis, neurological deficits, coughing with wheeze, nose bleeds, and fatigue among other symptoms. An infant was born with a total body flare, developed multiple Cafe-au-Lait pigmented skin spots and diagnoses with NF1 at age 2. The mycotoxins were detected in bulk samples, urine and nasal secretions, breast milk, placenta, and umbilical cord. Pseudomonas aueroginosa, Acinetobacter, Penicillium, and Aspergillus fumigatus were cultured from nasal secretions (father and daughter). RT-PCR revealed A. fumigatus DNA in sinus tissues of the daughter. The dog had 72 skin lesions (sebaceous glands and lipomas) from which trichothecene and ochratoxin A. were detected. The health of the family is discussed in relation to the most recent published literature regarding microbial contamination and toxic by-products present in water-damaged buildings.

  3. Oxytetracycline induces DNA damage and epigenetic changes: a possible risk for human and animal health?

    Science.gov (United States)

    Gallo, Adriana; Landi, Rosaria; Rubino, Valentina; Di Cerbo, Alessandro; Giovazzino, Angela; Palatucci, Anna Teresa; Centenaro, Sara; Guidetti, Gianandrea; Canello, Sergio; Cortese, Laura; Ruggiero, Giuseppina; Alessandrini, Andrea; Terrazzano, Giuseppe

    2017-01-01

    Oxytetracycline (OTC), which is largely employed in zootechnical and veterinary practices to ensure wellness of farmed animals, is partially absorbed within the gastrointestinal tract depositing in several tissues. Therefore, the potential OTC toxicity is relevant when considering the putative risk derived by the entry and accumulation of such drug in human and pet food chain supply. Despite scientific literature highlights several OTC-dependent toxic effects on human and animal health, the molecular mechanisms of such toxicity are still poorly understood. Here, we evaluated DNA damages and epigenetic alterations by quantitative reverse transcription polymerase chain reaction, quantitative polymerase chain reaction, chromatin immuno-precipitation and Western blot analysis. We observed that human peripheral blood mononuclear cells (PBMCs) expressed DNA damage features (activation of ATM and p53, phosphorylation of H2AX and modifications of histone H3 methylation of lysine K4 in the chromatin) after the in vitro exposure to OTC. These changes are linked to a robust inflammatory response indicated by an increased expression of Interferon (IFN)- γ and type 1 superoxide dismutase (SOD1). Our data reveal an unexpected biological in vitro activity of OTC able to modify DNA and chromatin in cultured human PBMC. In this regard, OTC presence in foods of animal origin could represent a potential risk for both the human and animal health.

  4. A Water-Damaged Home and Health of Occupants: A Case Study

    Directory of Open Access Journals (Sweden)

    Jack Dwayne Thrasher

    2012-01-01

    Full Text Available A family of five and pet dog who rented a water-damaged home and developed multiple health problems. The home was analyzed for species of mold and bacteria. The diagnostics included MRI for chronic sinusitis with ENT and sinus surgery, and neurological testing for neurocognitive deficits. Bulk samples from the home, tissue from the sinuses, urine, nasal secretions, placenta, umbilical cord, and breast milk were tested for the presence of trichothecenes, aflatoxins, and Ochratoxin A. The family had the following diagnosed conditions: chronic sinusitis, neurological deficits, coughing with wheeze, nose bleeds, and fatigue among other symptoms. An infant was born with a total body flare, developed multiple Cafe-au-Lait pigmented skin spots and diagnoses with NF1 at age 2. The mycotoxins were detected in bulk samples, urine and nasal secretions, breast milk, placenta, and umbilical cord. Pseudomonas aueroginosa, Acinetobacter, Penicillium, and Aspergillus fumigatus were cultured from nasal secretions (father and daughter. RT-PCR revealed A. fumigatus DNA in sinus tissues of the daughter. The dog had 72 skin lesions (sebaceous glands and lipomas from which trichothecenes and ochratoxin A. were detected. The health of the family is discussed in relation to the most recent published literature regarding microbial contamination and toxic by-products present in water-damaged buildings.

  5. Brief communication: On-site data collection of damage caused by flash floods: Experiences from Braunsbach, Germany, in May/June 2016

    Science.gov (United States)

    Laudan, Jonas; Rözer, Viktor; Sieg, Tobias; Vogel, Kristin; Thieken, Annegret

    2017-04-01

    At the end of May and beginning of June 2016, several municipalities in Southern Germany suffered from severe flash floods and debris flows which have been triggered by intense rainfall in Central Europe. Overall, the insured losses of these events amounted to EUR 1.2 billion in Germany. Especially the strong and unexpected flash flood on May 29th in Braunsbach (Baden Wurttemberg) - a small village counting about 1,000 residents - attracted media and policymakers due to its devastating character. The understanding of damage caused by flash floods requires ex-post collection of relevant but yet sparsely available information, linking process intensities to damage by using adequate methods of data gathering. Thus, on-site data collection was carried out after the flash flood event in Braunsbach, using open source software as helpful and efficient tool for data acquisition and evaluation. A digital survey was designed and conducted by a team of five researchers who investigated all buildings affected by water and debris flows. The collected data includes an estimation of a particular damage class, the inundation depth, and other relevant information. A post - hoc data analysis was done with R 3.3.1 and QGIS 2.14.3, performing both, a Random Forest Model (RF) and Random Generalized Linear Model (RGLM) as well as preparing a Spearman's rank correlation matrix. For visual interpretation and better overview of the study area and analysis results, a "process intensity" map was created, revealing important links of damage driving factors. We find that not only the water depth, which is often considered as only damage driving factor in riverine flood loss modelling, but also the exposition of a building to the flow direction and susceptible building parts like e.g. shop windows seem to be risk factors in flash-flood prone regions. Although no significant correlations were found, the analyses indicate that also building material (i.e. half-timbered or masonry) and structural

  6. Study of the damage rate caused by intervertebral foramen type inside and outside and the pass of the intervertebral DRG RF puncture way.

    Science.gov (United States)

    Sun, Jiashu; Zhang, Haitao

    2014-09-01

    This paper was to analyze and contrast the damage rate on the thoracic segment different position of the dorsal root ganglion(dorsal root ganglion, DRG) caused by different puncture path in radiofrequency ablation, thus the best RF target way for the thoracic segment of different types of DRG was confirmed. According to the difference of puncture and ablation damage way, 14 segmental spinal specimens were randomly divided into three groups, and then conducted DRG radiofrequency damage on percutaneous puncture path according to the type of DRG position.The damage effect of different puncture path by the judgment standard of the result of pathology analyzed. The experiment showed that RF damage of group A were 72.58 ± 18.88%, 54.16 ± 24.84% and 32.85 ± 28.11%; that of group B were 771.86 ± 15.15% and 72.02 ± 17.86%, 57.14 ± 18.02% and 52.47 ± 20.64%, 68.75 ± 14.63% and 71.78 ± 16.00%; and that of group C were 82.46 ± 14.10%, 81.53 ± 11.81% and 80.83 ± 13.33%. It was concluded that the singleness of DRG puncture route is one of the important reasons for the poor thoracic segments DRG radiofrequency (RF) ablation effect. While according to the type of DRG different positions with double joint puncture path can significantly improve the rate of DRG RF damage.

  7. Applying of centrifugal chromatography on DEAE cellulose and viscosity measurement to estimate damage caused by gamma irradiation in lymphocyte DNA

    International Nuclear Information System (INIS)

    Olinski, R.

    1977-01-01

    DNA isolated from limphocytes of pig blood was irradiated by γ radiation in the range of 0.5-50 Krads. Changes caused by irradiation (single and double breaks) were determined by using viscosity measurement and centrifugal chromatography on DEAE cellulose. Study of DNA chromatograms showed possibility to apply centrifugal chromatography on DEAE cellulose to estimate changes caused by irradiation. (author)

  8. Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells

    International Nuclear Information System (INIS)

    Chaudhari, Manjari; Jayaraj, R.; Bhaskar, A.S.B.; Lakshmana Rao, P.V.

    2009-01-01

    T-2 toxin is the most toxic trichothecene and both humans and animals suffer from several pathological conditions after consumption of foodstuffs contaminated with trichothecenes. We investigated the molecular mechanism of T-2 toxin induced cytotoxicity and cell death in HeLa cells. T-2 toxin at LC50 of 10 ng/ml caused time dependent increase in cytotoxicity as assessed by dye uptake, lactatedehydrogenase leakage and MTT assay. The toxin caused generation of reactive oxygen species as early as 30 min followed by significant depletion of glutathione levels and increased lipid peroxidation. The results indicate oxidative stress as underlying mechanism of cytotoxicity. Single stranded DNA damage after T-2 treatment was observed as early as 2 and 4 h by DNA diffusion assay. The cells exhibited apoptotic morphology like condensed chromatin and nuclear fragmentation after 4 h of treatment. Downstream of T-2 induced oxidative stress and DNA damage a time dependent increase in expression level of p53 protein was observed. The increase in Bax/Bcl2 ratio indicated shift in response, in favour of apoptotic process in T-2 toxin treated cells. Western blot analysis showed increase in levels of mitochondrial apoptogenic factors Bax, Bcl-2, cytochrome-c followed by activation of caspases-9, -3 and -7 leading to DNA fragmentation and apoptosis. In addition to caspase-dependent pathway, our results showed involvement of caspase-independent AIF pathway in T-2 induced apoptosis. Broad spectrum caspase inhibitor z-VAD-fmk could partially protect the cells from DNA damage but could not inhibit AIF induced oligonucleosomal DNA fragmentation beyond 4 h. Results of the study clearly show that oxidative stress is the underlying mechanism by which T-2 toxin causes DNA damage and apoptosis.

  9. Probable causes of damage of heat-exchange tubes of low-pressure-exchanges of PND-3 type and repair methods

    Science.gov (United States)

    Trifonov, N. N.; Esin, S. B.; Nikolaenkova, E. K.; Sukhorukov, Yu. G.; Svyatkin, F. A.; Sintsova, T. G.; Modestov, V. S.

    2017-08-01

    The structures of low-pressure heaters (LPH), which are installed at nuclear power plants with the K-1000-60/1500 type turbine plants are considered. It was revealed that only the PND-3 type low-pressure heaters have the damages of the heat exchange tubes. For a short operation life, the number of the damaged heat-exchange tubes of PND-3 is approximately 50 pcs for Kalinin NPP and 100-150 pcs for Balakovo NPP. The low-pressure heaters were manufactured at AO Ural Plant of Chemical Machine-Building "Uralkhimmash," OAO Taganrog Boiler-Making Works "Krasny Kotelshchik," and Vitkovice Machinery Group, but the damage nature of the heat-exchange tubes is identical for all PND-3. The damages occur in the place of passage of the heat exchange tubes through the first, the second, and the third partitions over the lower tube plate (the first path of the turbine condensate). Hydraulic shocks can be one of the possible causes of the damage of the heat-exchange tubes of PND-3. The analysis of the average thermal and dynamic loads of the tube systems of PND-1-PND-4 revealed that PND-3 by the thermal power are loaded 1.4-1.6 times and by the dynamic effects are loaded 1.8-2.0 times more than the remaining LPHs. Another possible cause of damage can be the cascaded drain of the separate into PND-4 and then through the drainage heat exchange into PND-3. An additional factor can be the structure of the condensate drainage unit. The advanced system of the heating steam flow and pumping scheme of the separate drain using the existing drainage pumps of PND-3 for K-1000-60/1500 turbine plants for Balakovo and Kalinin NPPs were proposed. The considered decisions make it possible to reduce the flow rate of the heating steam condensate from PND-3 into PND-4 and the speed of the heating steam in the tube space of PND-3 and eliminate the occurrence of hydraulic shocks and damages of the heat exchanger tubes.

  10. Liability for damage caused by ground subsidence in the Netherlands. The role of the Mining Law and the Technical Committee Ground Subsidence

    International Nuclear Information System (INIS)

    Roggenkamp, M.M.; Verwer, Ch.P.

    2004-01-01

    This article provides an overview of the legal regulatory framework in respect of movements of the soil (i.e. subsidence and earth tremors) following the exploration and extraction of minerals in the Netherlands, and the liability for the damage they cause. This legal framework has been changed considerably since the new Mining Act came into force on January 1st, 2003. After having examined the causes of subsidence and subsequent earth tremors, and relationships with the exploration and extraction of subsoil minerals such as oil, gas, salt and coal, the article continues by presenting the legislation of this area. The authors analyse the applicable legislation before as well as after the introduction of the new Mining Act. The two judicial regimen have a similar approach: While the rules and regulations concerning earth movements are laid down in the Mining Act, the legal foundation for the liability for damage resulting from earth movements is provided by the Civil Code. The parliamentary debates on the Mining Bill specifically dealt with the issue of earth movements and the question whether either a system of absolute (vicarious) liability would apply, or a system of strict liability. One of the reasons for not having a system of absolute liability was the wish of Parliament to lay down in the Mining Act provisions for the creation of a Technical Committee on Earth Movements. It is the remit of this Committee to advise the Minister of Economic Affairs on all matters related to movements of the soil. It's duty is also to advise on the causal) relationship between mining activities and earth movements, and the amount of damages to be paid by the mining companies, at the request of individual persons. In order to avoid individuals not receiving any compensation for damages, the new Mining Act also calls for the introduction of a special Fund for Mining Damages. Individual persons would be entitled to make a claim to this fund in situations such as the mining company

  11. Medial temporal lobe damage causes deficits in episodic memory and episodic future thinking not attributable to deficits in narrative construction.

    Science.gov (United States)

    Race, Elizabeth; Keane, Margaret M; Verfaellie, Mieke

    2011-07-13

    The medial temporal lobe (MTL) makes critical contributions to episodic memory, but its contributions to episodic future thinking remain a matter of debate. By one view, imagining future events relies on MTL mechanisms that also support memory for past events. Alternatively, it has recently been suggested that future thinking is independent of MTL-mediated processes and can be supported by regions outside the MTL. The current study investigated the nature and necessity of MTL involvement in imagining the future and tested the novel hypothesis that the MTL contributes to future thinking by supporting online binding processes related to narrative construction. Human amnesic patients with well characterized MTL damage and healthy controls constructed narratives about (1) future events, (2) past events, and (3) visually presented pictures. While all three tasks place similar demands on narrative construction, only the past and future conditions require memory/future thinking to mentally generate relevant narrative information. Patients produced impoverished descriptions of both past and future events but were unimpaired at producing detailed picture narratives. In addition, future-thinking performance positively correlated with episodic memory performance but did not correlate with picture narrative performance. Finally, future-thinking impairments were present when MTL lesions were restricted to the hippocampus and did not depend on the presence of neural damage outside the MTL. These results indicate that the ability to generate and maintain a detailed narrative is preserved in amnesia and suggest that a common MTL mechanism supports both episodic memory and episodic future thinking.

  12. Medial Temporal Lobe Damage Causes Deficits in Episodic Memory and Episodic Future Thinking Not Attributable to Deficits in Narrative Construction

    Science.gov (United States)

    Race, Elizabeth; Keane, Margaret M.; Verfaellie, Mieke

    2015-01-01

    The medial temporal lobe (MTL) makes critical contributions to episodic memory, but its contributions to episodic future thinking remain a matter of debate. By one view, imagining future events relies on MTL mechanisms that also support memory for past events. Alternatively, it has recently been suggested that future thinking is independent of MTL-mediated processes and can be supported by regions outside the MTL. The current study investigated the nature and necessity of MTL involvement in imagining the future and tested the novel hypothesis that the MTL contributes to future thinking by supporting online binding processes related to narrative construction. Human amnesic patients with well-characterized MTL damage and healthy controls constructed narratives about (a) future events, (b) past events, and (c) visually-presented pictures. While all three tasks place similar demands on narrative construction, only the past and future conditions require memory/future thinking to mentally generate relevant narrative information. Patients produced impoverished descriptions of both past and future events but were unimpaired at producing detailed picture narratives. In addition, future-thinking performance positively correlated with episodic memory performance but did not correlate with picture narrative performance. Finally, future-thinking impairments were present when MTL lesions were restricted to the hippocampus and did not depend on the presence of neural damage outside the MTL. These results indicate that the ability to generate and maintain a detailed narrative is preserved in amnesia and suggest that a common MTL mechanism supports both episodic memory and episodic future thinking. PMID:21753003

  13. Comparison of tissue damage caused by various laser systems with tissue tolerable plasma by light and laser scan microscopy

    International Nuclear Information System (INIS)

    Vandersee, Staffan; Lademann, Jürgen; Richter, Heike; Patzelt, Alexa; Lange-Asschenfeldt, Bernhard

    2013-01-01

    Tissue tolerable plasma (TTP) represents a novel therapeutic method with promising capabilities in the field of dermatological interventions, in particular disinfection but also wound antisepsis and regeneration. The energy transfer by plasma into living tissue is not easily educible, as a variety of features such as the medium’s actual molecule-stream, the ions, electrons and free radicals involved, as well as the emission of ultraviolet, visible and infrared light contribute to its increasingly well characterized effects. Thus, relating possible adversary effects, especially of prolonged exposure to a single component of the plasma’s mode of action, is difficult. Until now, severe adverse events connected to plasma exposure have not been reported when conducted according to existing therapeutic protocols. In this study, we have compared the tissue damage-potential of CO 2 and dye lasers with TTP in a porcine model. After exposure of pig ear skin to the three treatment modalities, all specimens were examined histologically and by means of laser scan microscopy (LSM). Light microscopical tissue damage could only be shown in the case of the CO 2 laser, whereas dye laser and plasma treatment resulted in no detectable impairment of the specimens. In the case of TTP, LSM examination revealed only an impairment of the uppermost corneal layers of the skin, thus stressing its safety when used in vivo. (letter)

  14. Oxcarbazepine causes neurocyte apoptosis and developing brain damage by triggering Bax/Bcl-2 signaling pathway mediated caspase 3 activation in neonatal rats.

    Science.gov (United States)

    Song, Y; Zhong, M; Cai, F-C

    2018-01-01

    Anti-epileptic drugs (AEDs) are the main methods for treatment of neonatal seizures; however, a few AEDs may cause developing brain damage of neonate. This study aims to investigate effects of oxcarbazepine (OXC) on developing brain damage of neonatal rats. Both of neonatal and adult rats were divided into 6 groups, including Control, OXC 187.5 mg/kg, OXC 281.25 mg/kg, OXC 375 mg/kg group, LEV and PHT group. Body weight and brain weight were evaluated. Hematoxylin and eosin (HE) and Nissl staining were used to observe neurocyte morphology and Nissl bodies, respectively. Apoptosis was examined using TUNEL assay, and caspase 8 activity was evaluated using spectrophotometer method. Cytochrome C-release was evaluated using flow cytometry. Western blot was used to examine Bax and Bcl-2 expression. OXC 375 mg/kg treatment significantly decreased brain weight compared to Control group in neonatal rats (P5 rats) (pOxcarbazepine at a concentration of 281.25 mg/kg or more causes neurocyte apoptosis and developing brain damage by triggering Bax/Bcl-2 signaling pathway mediated caspase 3 activation in neonatal rats.

  15. Damage caused to houses and equipment by underground nuclear explosions; Degats dus aux explosions nucleaires souterraines sur les habitations et les equipements

    Energy Technology Data Exchange (ETDEWEB)

    Delort, F; Guerrini, C [Commissariat a l' Energie Atomique, Bruyeres-le-Chatel (France). Centre d' Etudes

    1969-07-01

    A description is given of the damaged caused to various structures, buildings, houses, mechanical equipment and electrical equipment by underground nuclear explosions in granite. For each type of equipment or building are given the limiting distances for a given degree of damage. These distances have been related to a parameter characterizing the movement of the medium; it is thus possible to generalize the results obtained in granite, for different media. The problem of estimating the damage caused at a greater distance from the explosion is considered. (authors) [French] Les degats sur diverses structures, constructions, habitations, equipements mecaniques et materiels electriques provoques par des explosions nucleaires souterraines dans le granite sont decrits. On a indique pour chaque type de materiel ou de construction, les distances limites correspondant a un degre de gravite de dommage observe. Ces distances ont ete reliees a un parametre caracterisant le mouvement du milieu, permettant ainsi de generaliser les resultats obtenus dans le granite, a differents milieux. Le probleme de la prevision des degats en zone lointaine a ete aborde. (auteurs)

  16. Use of damage surveys and field inventories to evaluate oak and sugar maple health in the northern United States

    Science.gov (United States)

    Randall S Morin; Christopher W. Woodall; Jim Steinman; Charles H. Perry

    2009-01-01

    Oak species (Quercus spp.) and sugar maple (Acer saccharum) are substantial components of the forest ecosystems in the 24-state region spanning the northern U.S. During recent decades, both damage surveys and forest inventories have documented declines of sugar maple and oak health. In order to more fully assess the status of oak and sugar maple health, we examined...

  17. Cell wall damage and oxidative stress in Candida albicans ATCC10231 and Aspergillus niger caused by palladium nanoparticles.

    Science.gov (United States)

    Athie-García, Martha Samira; Piñón-Castillo, Hilda Amelia; Muñoz-Castellanos, Laila Nayzzel; Ulloa-Ogaz, Ana Laura; Martínez-Varela, Perla Ivonne; Quintero-Ramos, Armando; Duran, Robert; Murillo-Ramirez, José Guadalupe; Orrantia-Borunda, Erasmo

    2018-04-01

    In this work the toxic effect of Palladium nanoparticles (PdNPs) was investigated in two eukaryotic cell models, Candida albicans and Aspergillus niger. PdNPs were synthesized by chemical reduction method, obtaining spherical NPs with a primary size ranging from 3 to 15 nm. PdNPs showed a hydrodynamic size of 1548 nm in Lee's minimum media. Minimal inhibitory concentration was determined at 200 and 250 ppm for Candida albicans and Aspergillus niger respectively, revealing a significant cell growth inhibition (ANOVA and tukey analysis, α = 0.5). Reactive Oxygen Species levels were increased in both microorganisms. Confocal, scanning and transmission electron microscopy studies revealed cell wall damage and cellular morphology changes, induced by the interaction of PdNPs, in both microorganisms. Copyright © 2018 Elsevier Ltd. All rights reserved.

  18. Effect of certain natural antioxidants in protecting against damage caused by gamma radiation in ischemic rat intestine

    International Nuclear Information System (INIS)

    Hassan, T.A.A.

    2009-01-01

    Oxidative stress plays an important role in various clinical pathologies one of which is ischemia/reperfusion (I/R)- induced injury. Intestinal I/R enhances production of reactive oxygen species (ROS), inflammatory mediators and induces apoptosis. In other hand. the intestinal tract shows a high sensitivity to ionizing radiation due to a rapid cell turnover and is often implicated in radiation sickness the radiation damage may either be a consequence of a direct effect resulting in disruption of critical molecule (such as an enzyme or DNA) or an indirect effect through ionization of water molecules and formation of ROS. consequently, supplementation of antioxidants may be a beneficial approach to protect against cellular damages associated with oxidative stress. the current study was aimed to evaluate the possible protective effects of vitamin E (100 mg/kg p.o.), tomato extract (67 mg/kg. p.o.) and turmeric (100 mg/kg, p.o) against ileal injury induced in rats by total occlusion of the superior mesenteric artery for 30 min followed by reperfusion for another 30 min. Furthermore, this protective effect of the mentioned drugs was extended into injury that could happened in ileal tissues of rats exposed to (6 Gy) gamma radiation followed by intestinal I/R. Drugs were administered one daily for 14 consecutive days prior to the ischemic insult. Damage induced by I/R was manifested by depletion of ileal content of reduced glutathion (GSH) as well as Lactate dehydrogenas (LDH) activity, associated with elevation of ileal contents of thiobarbituric acid reactive substances (TBARS), nitrite, tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Intestinal ischemic insults were exacerbated by radiation injury on comparing different untreated controls; except the ileal content of GSH which has elevated due to the preconditioning effect of irradiation. Vitamin E provided a significant protection against the decrease in LDH activity as well as the increase in TBARS

  19. Assessment of DNA damages caused by exposure of bacterial cells and spores to the Mars surface environment

    Science.gov (United States)

    Fajardo-Cavazos, Patricia; Schuerger, Andrew; Robles-Martinez, Jose; Douki, Thierry; Nicholson, Wayne

    Joint NASA and ESA missions are planned for the next decade to investigate the possibility of present or past life on Mars [1]. Evidence of extraterrestrial life will likely rely on the de-tection of biomarkers, highlighting the importance of preventing forward contamination not only with viable microorganisms, but also with biomolecules that could compromise the valid-ity of life-detection experiments [2-4]. The designation of DNA as a high-priority biomarker makes it necessary to evaluate its persistence in extraterrestrial environments, and the effects of exposure on its biological activity. To accomplish this, we deposited naked DNA, cells and spores of Bacillus subtilis 168 or B. pumilus SAFR-032, or cells of Acinetobacter radioresistens 50v1 onto spacecraft-qualified aluminum coupons. Samples were exposed to a simulated Mars surface environment as described in detail previously [4, 5] for various periods of time, and DNA damage was assessed by a number of measurements. Double-and single-strand breaks were measured by neutral and alkaline agarose gel electrophoresis, and DNA bipyrimidine pho-toproducts were measured by HPLC-mass spectrometry, as described previously [6, 7]. Loss of functionality of DNA to serve as a template for replication by DNA polymerase was measured using a quantitative polymerase chain reaction (qPCR) assay [8]. In all cases, DNA damage was directly correlated with time of exposure to simulated martian solar radiation (UV, visible, and infrared wavelengths). Exposure of samples to Mars surface conditions, but shielded from solar radiation, did not result in appreciable damage over the time periods tested, relative to controls. DNA contained within cells or spores was much less susceptible to damage than was naked DNA. Using the qPCR assay, we found that inactivation of naked DNA or DNA extracted from exposed spores of B. subtilis followed a multiphasic dose-response, and that a fraction of DNA molecules retained functionality after

  20. Radiation in relation to mutation rate, mutational damage and human ill-health

    International Nuclear Information System (INIS)

    Roberts, P.B.

    1976-09-01

    The effect of radiation in increasing the frequency of gene mutations is now reasonably understood. We discuss first how an increase in the mutation rate is reflected in the mutational damage expressed in populations. It is shown that the mutational damage, assessed by the loss of fitness in a population or the number of eventual gene extinctions, is equal to the number of new mutations arising per generation or the mutation rate. In a population of stable size, a dose of 1 rem given to 10 6 people leads to roughly 600 gene extinctions when summed over all ensuing generations if the dose is applied to only one generation; this number of extinctions will occur in each succeeding generation if the dose is given to every generation. However, the concept of genetic extinction, although quantifiable, is of limited value in assessing radiation risks since its impact on human ill-health is very speculative. In particular, no estimate can be made of the total cost of effects which are minor in each individual in which they arise, but which, because they are so minor, persist in the population for many generations. The best current estimate is for 14-140 obvious defects in the first few generations following exposure of 10 6 people to a dose of 1 rem. (auth.)

  1. [Inhalation of gasoline and damage to health in workers at gas stations].

    Science.gov (United States)

    Pranjić, Nurka; Mujagić, H; Pavlović, S

    2003-01-01

    The aim of this study was to made assessment of chronic health effects in 37 workers exposed to gasoline, and its constituents at gasoline stations between 1985 and 1996. By the study we have involved thirty-seven persons who had been exposed to gasoline for more than five years were examined. The evaluation included a medical/occupational history, hematological and biochemical examination, a physical exam, standardized psychological tests, and ultrasound examination of kidneys and liver. The groups were identical in other common parameters including age, gender (all men), and level of education (P gasoline unexposed controls and 25 workers at gasoline stations exposed to organic lead for only nine months. Peripheral smear revealed basophilic punctuated eritrocytes and reticulocytosis. We found in chronic exposed gasoline workers haematological disorders: mild leukocytosis (7 of 37), lymphocytosis (20 of 37), mild lymhocytopenia (3 of 37), decrease of red blood cells count (11 of 37). Results indicated that they have suffered from liver disorders: lipoid degeneration of liver (14 of 37), chronic functional damages of liver (3 of 37), cirrhosis (1 of 37). Ultrasound examination indicated chronic kidney damages (8 of 37). These results significantly differed from those of controls (P gasoline stations exposed to gasoline for more than 5 years the symptom of depression and decreased reaction time and motor abilities were identified. The summary of diseases of workers exposed to organic lead and gasoline are discussed.

  2. Uncertainty Evaluation in the Design of Structural Health Monitoring Systems for Damage Detection†

    Directory of Open Access Journals (Sweden)

    Christine Schubert Kabban

    2018-04-01

    Full Text Available The validation of structural health monitoring (SHM systems for aircraft is complicated by the extent and number of factors that the SHM system must demonstrate for robust performance. Therefore, a time- and cost-efficient method for examining all of the sensitive factors must be conducted. In this paper, we demonstrate the utility of using the simulation modeling environment to determine the SHM sensitive factors that must be considered for subsequent experiments, in order to enable the SHM validation. We demonstrate this concept by examining the effect of SHM system configuration and flaw characteristics on the response of a signal from a known piezoelectric wafer active sensor (PWAS in an aluminum plate, using simulation models of a particular hot spot. We derive the signal responses mathematically and through the statistical design of experiments, we determine the significant factors that affect the damage indices that are computed from the signal, using only half the number of runs that are normally required. We determine that the transmitter angle is the largest source of variation for the damage indices that are considered, followed by signal frequency and transmitter distance to the hot spot. These results demonstrate that the use of efficient statistical design and simulation may enable a cost- and time-efficient sequential approach to quantifying sensitive SHM factors and system validation.

  3. Vibration based structural health monitoring of an arch bridge: From automated OMA to damage detection

    Science.gov (United States)

    Magalhães, F.; Cunha, A.; Caetano, E.

    2012-04-01

    In order to evaluate the usefulness of approaches based on modal parameters tracking for structural health monitoring of bridges, in September of 2007, a dynamic monitoring system was installed in a concrete arch bridge at the city of Porto, in Portugal. The implementation of algorithms to perform the continuous on-line identification of modal parameters based on structural responses to ambient excitation (automated Operational Modal Analysis) has permitted to create a very complete database with the time evolution of the bridge modal characteristics during more than 2 years. This paper describes the strategy that was followed to minimize the effects of environmental and operational factors on the bridge natural frequencies, enabling, in a subsequent stage, the identification of structural anomalies. Alternative static and dynamic regression models are tested and complemented by a Principal Components Analysis. Afterwards, the identification of damages is tried with control charts. At the end, it is demonstrated that the adopted processing methodology permits the detection of realistic damage scenarios, associated with frequency shifts around 0.2%, which were simulated with a numerical model.

  4. Understanding the distribution of strong motions and the damage caused during the September 19th, 2017 earthquake

    Science.gov (United States)

    Aguirre, J.; Ramirez-Guzman, L.; Leonardo Suárez, M.; Quintanar, L.

    2017-12-01

    On September 19, 2017, a normal fault earthquake of magnitude Mw 7.1 occurred 120 km from Mexico City. The quake generated large accelerations, more than 200 cm/s*s at least in two stations in Mexico City, where there was extensive damage. The damage pattern, which includes more than 40 building collapses, differs from the one induced by the 1985 Michoacan earthquake. While the observed accelerations in stations located in the Hill and Transition zones are the largest ever recorded, in the Lake zone the intensities were lower than those recorded in 1985. Even though the proximity of the epicenter could partially explain the accelerations, other factors need to be explored to understand the nuances of the ground motion. Unlike 1985, there is a substantially larger number of acceleration records in Mexico City, operated and maintained by different institutions. In this paper, we present the analysis of acceleration records and 3D numerical simulations to understand if effects such as focusing and directionality participate in the amplified motion. Finally, transfer functions between Lake and Hill zones and response and design spectral values are analyzed in regions where the building code requirements were exceeded. Acknowledgments: Records used in this research are obtained, processed and maintained by the National Autonomous University of Mexico through the Seismic Instrumentation Unit of the Institute of Engineering and the National Seismological Service of the Institute of Geophysics. The Centro de Intrumentacion y Registro Sismico A.C. (CIRES) kindly provided their records. This Project was funded in part by the Secretaria de Ciencia, Tecnología e Innovación (SECITI) of Mexico City. Project SECITI/073/2016.

  5. GIS UTILITY FOR HYDROLOGICAL IMPACT EVALUATION CAUSED BY DAMAGES OF WATER SUPPLY NETWORK IN RURAL AREAS. APPLICATIONS IN BAIA MARE DEPRESSION

    Directory of Open Access Journals (Sweden)

    RADU ALEXANDRU MARIAN

    2012-11-01

    Full Text Available GIS utility for hydrological impact evaluation caused by damages of water supply network in rural areas. Applications in Baia Mare Depression. Occurrence of a failure within the water supply network is an element of risk with important hydrological implications. Although at first glance you might think that a pipe diameter of only 20 cm can generate large effects, however, in case of significant damage or even burst pipe, a good part of high water flow in the pipe (approx. 25 m3/h on average in the Baia Mare associated with a long duration of failure (several hours may be in the drain area, impact on the local community. Regarding rural settlements, surface drainage allow a quantity of water retention tank underground infiltration but in many cases lack of a sewage system effectively contribute to increased negative consequences related to such damage (flooding farms, roads, crops compromise of flooding or drought in the event of damage to the hot water supply pipe and so on. This paper focuses on the role of Geographic Information Systems (GIS to assess the impact of runoff induced by damages in rural areas. The study therefore spatial aspect, through GIS, on the one hand runoff along the flow path with the start point of the network fault location and view previous hydrological conditions of the terrain, and on the other hand the impact of runoff the rural community. Study area Dumbrăviţa settlement located in Baia Mare Depression. This village is part of water supply system to the south and southeast of Baia Mare.

  6. Base excision repair of chemotherapeutically-induced alkylated DNA damage predominantly causes contractions of expanded GAA repeats associated with Friedreich's ataxia.

    Directory of Open Access Journals (Sweden)

    Yanhao Lai

    Full Text Available Expansion of GAA·TTC repeats within the first intron of the frataxin gene is the cause of Friedreich's ataxia (FRDA, an autosomal recessive neurodegenerative disorder. However, no effective treatment for the disease has been developed as yet. In this study, we explored a possibility of shortening expanded GAA repeats associated with FRDA through chemotherapeutically-induced DNA base lesions and subsequent base excision repair (BER. We provide the first evidence that alkylated DNA damage induced by temozolomide, a chemotherapeutic DNA damaging agent can induce massive GAA repeat contractions/deletions, but only limited expansions in FRDA patient lymphoblasts. We showed that temozolomide-induced GAA repeat instability was mediated by BER. Further characterization of BER of an abasic site in the context of (GAA20 repeats indicates that the lesion mainly resulted in a large deletion of 8 repeats along with small expansions. This was because temozolomide-induced single-stranded breaks initially led to DNA slippage and the formation of a small GAA repeat loop in the upstream region of the damaged strand and a small TTC loop on the template strand. This allowed limited pol β DNA synthesis and the formation of a short 5'-GAA repeat flap that was cleaved by FEN1, thereby leading to small repeat expansions. At a later stage of BER, the small template loop expanded into a large template loop that resulted in the formation of a long 5'-GAA repeat flap. Pol β then performed limited DNA synthesis to bypass the loop, and FEN1 removed the long repeat flap ultimately causing a large repeat deletion. Our study indicates that chemotherapeutically-induced alkylated DNA damage can induce large contractions/deletions of expanded GAA repeats through BER in FRDA patient cells. This further suggests the potential of developing chemotherapeutic alkylating agents to shorten expanded GAA repeats for treatment of FRDA.

  7. Understanding fear of cancer recurrence in terms of damage to 'everyday health competence'.

    Science.gov (United States)

    Horlick-Jones, Tom

    2011-09-01

    Advances in clinical treatments are resulting in cancer patients living longer, but with the threat of the disease returning at some later date. Anxiety associated with this fear of recurrence, which seems widespread among patients, can lead to an enhanced bodily awareness and a pronounced tendency to interpret mundane sensations as symptoms of pathology. Relatively little sociological work has been done to systematically document, understand, and find ways of addressing, this syndrome and its impact on the quality of patients' lives. It is argued that this syndrome is best understood not in cognitive terms, as a form of irrationality, but rather as resulting from damage to certain aspects of social competence, namely one's 'everyday health competence'. In investigating this issue, the author draws upon his personal experience of breast cancer diagnosis, surgery and adjuvant therapy; and on a broadly phenomenological approach to examining the relationship between bodily sensations and practical reasoning about experience. The implications for clinical practice are considered briefly. © 2011 The Author. Sociology of Health & Illness © 2011 Foundation for the Sociology of Health & Illness/Blackwell Publishing Ltd.

  8. Identification Of Damages Of Tribological Associations In Crankshaft And Piston Systems Of Two-Stroke Internal Combustion Engines Used As Main Propulsion In Sea-Going Vessels And Proposal Of Probabilistic Description Of Loads As Causes Of These Damages

    Directory of Open Access Journals (Sweden)

    Girtler Jerzy

    2015-04-01

    Full Text Available The article discusses damages of essential tribological associations in crankshaft and piston systems of large power two-stroke engines used as main engines, which take place during transport tasks performed by those ships. Difficulties are named which make preventing those damages impossible, despite the fact that the technical state of engines of this type is identified with the aid of complex diagnostic systems making use of advanced computer technology. It is demonstrated that one of causes of the damages is the lack of research activities oriented on recognising random properties of the loads leading to those damages. A proposal is made for the loads acting at a given time t on tribological associations in crankshaft and piston systems of internal combustion engines used as main engines to be considered as random variables Qt. At the same time the loads examined within a given time interval tr ≤ t ≤ tz would be considered stochastic processes {Q(t: t ≥ 0}. Essential properties of the loads of the abovementioned tribological associations are named and explained by formulating hypotheses which need empirical verification. Interval estimation is proposed for estimating the expected value E(Qt of the load Qt acting at time t. A relation is indicated between the mechanical load and the thermal load acting on tribological associations in the ship main engine crankshaft and piston system. A suggestion is formulated that a stochastic form of the relation between these types of load is to be searched for, rather than statistic relation, and a proposal is made to measure the intensity (strength of the stochastic relation using the Czuprow’s convergence coefficient.

  9. Systemic agonistic anti-CD40 treatment of tumor bearing mice modulates hepatic myeloid suppressive cells and causes immune-mediated liver damage

    Science.gov (United States)

    Medina-Echeverz, José; Ma, Chi; Duffy, Austin; Eggert, Tobias; Hawk, Nga; Kleiner, David E.; Korangy, Firouzeh; Greten, Tim F.

    2015-01-01

    Immune stimulatory monoclonal antibodies are currently evaluated as anti tumor agents. Although overall toxicity appears to be moderate, liver toxicities have been reported and are not completely understood. We studied the effect of systemic CD40 antibody treatment on myeloid cells in spleen and liver. Naïve and tumor-bearing mice were treated systemically with agonistic anti-CD40 antibody. Immune cell subsets in liver and spleen, serum transaminases and liver histologies were analyzed after antibody administration. Nox2−/−, Cd40−/− as well as bone marrow chimeric mice were used to study the mechanism by which agonistic anti-CD40 mediates its effects in vivo. Suppressor function of murine and human tumor-induced myeloid derived suppressive cells was studied upon CD40 ligation. Agonistic CD40 antibody caused liver damage within 24 hours after injection in two unrelated tumor models and mice strains. Using bone marrow chimeras we demonstrated that CD40 antibody-induced hepatitis in tumor-bearing mice was dependent on the presence of CD40-expressing hematopoietic cells. Agonistic CD40 ligation-dependent liver damage was induced by the generation of reactive oxygen species. Furthermore, agonistic CD40 antibody resulted in increased CD80 and CD40 positive liver CD11b+Gr-1+ immature myeloid cells. CD40 ligation on tumor-induced murine and human CD14+HLA-DRlow PBMC from cancer patients reduced their immune suppressor function. Collectively, agonistic CD40 antibody treatment activated tumor-induced, myeloid cells, caused myeloid dependent hepatotoxicity and ameliorated the suppressor function of murine and human MDSC. Collectively, our data suggests that CD40 may mature immunosuppressive myeloid cells and thereby cause liver damage in mice with an accumulation of tumor-induced hepatic MDSC. PMID:25637366

  10. 78 FR 4295 - Engaging in Public Health Research on the Causes and Prevention of Gun Violence

    Science.gov (United States)

    2013-01-22

    ... Public Health Research on the Causes and Prevention of Gun Violence Memorandum for the Secretary of Health and Human Services In addition to being a law enforcement challenge, gun violence is also a... violence and the successful efforts in place for preventing the misuse of firearms. Taking these steps will...

  11. Deficiency of methionine sulfoxide reductase A causes cellular dysfunction and mitochondrial damage in cardiac myocytes under physical and oxidative stresses

    International Nuclear Information System (INIS)

    Nan, Changlong; Li, Yuejin; Jean-Charles, Pierre-Yves; Chen, Guozhen; Kreymerman, Alexander; Prentice, Howard; Weissbach, Herbert; Huang, Xupei

    2010-01-01

    Research highlights: → Deficiency of MsrA in the heart renders myocardial cells more sensitive to oxidative stress. → Mitochondrial damage happens in the heart lacking MsrA. → More protein oxidation in myocardial cells lacking MsrA. → MsrA protects the heart against oxidative stress. -- Abstract: Methionine sulfoxide reductase A (MsrA) is an enzyme that reverses oxidation of methionine in proteins. Using a MsrA gene knockout (MsrA -/- ) mouse model, we have investigated the role of MsrA in the heart. Our data indicate that cellular contractility and cardiac function are not significantly changed in MsrA -/- mice if the hearts are not stressed. However, the cellular contractility, when stressed using a higher stimulation frequency (2 Hz), is significantly reduced in MsrA -/- cardiac myocytes. MsrA -/- cardiac myocytes also show a significant decrease in contractility after oxidative stress using H 2 O 2 . Corresponding changes in Ca 2+ transients are observed in MsrA -/- cardiomyocytes treated with 2 Hz stimulation or with H 2 O 2 . Electron microscope analyses reveal a dramatic morphological change of mitochondria in MsrA -/- mouse hearts. Further biochemical measurements indicate that protein oxidation levels in MsrA -/- mouse hearts are significantly higher than those in wild type controls. Our study demonstrates that the lack of MsrA in cardiac myocytes reduces myocardial cell's capability against stress stimulations resulting in a cellular dysfunction in the heart.

  12. Damage of niobium surfaces caused by bombardment with 4He+ ions of different energies typical for T-20

    International Nuclear Information System (INIS)

    Guseva, M.I.; Gusev, V.; Martynenko, Yu.V.; Das, S.K.; Kaminsky, N.

    1979-01-01

    The surface damage of cold worked and annealed polycrystalline Nb irradiated at room temperature with He + ions sequentially at different energies over the range from 0.5 keV to 1.8 MeV has been investigated. The individual energy and the dose of the He + ion was chosen to match the theoretically calculated He + ion spectrum expected in the Tokamak T-20. In one set of irradiations, targets were irradiated at Kurchatov Institute starting with 0.5 keV 4 He + ions and extending up to 90 keV in eleven steps. Subsequently, the same area was irradiated at ANL starting at 150 keV and increased in eight steps up to 1.8 MeV. The irradiations were carried out for a total dose of 5.0 C/cm 2 . In another set of irradiations the sequence was reversed. Scanning electron microscopy results show formation of blisters and exfoliation. For the same dose the broad energy implant (due to sequential irradiation) appears to decrease the blister diameter and density as compared to irradiation with monoenergetic He + ions at a given energy (in the energy range considered). Some estimates of surface erosion yields due to blistering are given

  13. Whole body proton irradiation causes acute damage to bone marrow hematopoietic progenitor and stem cells in mice.

    Science.gov (United States)

    Chang, Jianhui; Wang, Yingying; Pathak, Rupak; Sridharan, Vijayalakshmi; Jones, Tamako; Mao, Xiao Wen; Nelson, Gregory; Boerma, Marjan; Hauer-Jensen, Martin; Zhou, Daohong; Shao, Lijian

    2017-12-01

    Exposure to proton irradiation during missions in deep space can lead to bone marrow injury. The acute effects of proton irradiation on hematopoietic stem and progenitor cells remain undefined and thus were investigated. We exposed male C57BL/6 mice to 0.5 and 1.0 Gy proton total body irradiation (proton-TBI, 150 MeV) and examined changes in peripheral blood cells and bone marrow (BM) progenitors and LSK cells 2 weeks after exposure. 1.0 Gy proton-TBI significantly reduced the numbers of peripheral blood cells compared to 0.5 Gy proton-TBI and unirradiated animals, while the numbers of peripheral blood cell counts were comparable between 0.5 Gy proton-TBI and unirradiated mice. The frequencies and numbers of LSK cells and CMPs in BM of 0.5 and 1.0 Gy irradiated mice were decreased in comparison to those of normal controls. LSK cells and CMPs and their progeny exhibited a radiation-induced impairment in clonogenic function. Exposure to 1.0 Gy increased cellular apoptosis but not the production of reactive oxygen species (ROS) in CMPs two weeks after irradiation. LSK cells from irradiated mice exhibited an increase in ROS production and apoptosis. Exposure to proton-TBI can induce acute damage to BM progenitors and LSK cells.

  14. Effect of loperamide and delay of bowel motility on bile acid malabsorption caused by late radiation damage and ileal resection

    Energy Technology Data Exchange (ETDEWEB)

    Valdes Olmos, R. (Nederlands Kanker Inst., Amsterdam (Netherlands). Dept. of Nuclear Medicine); Hartog Jager, F. den; Hoefnagel, C.; Taal, B. (Nederlands Kanker Inst., Amsterdam (Netherlands). Dept. of Gastroenterology)

    1991-05-01

    Selenium-75 homocholic acid conjugated with taurine ({sup 75}Se-HCAT) was used during loperamide administration in seven patients suspected of having bile acid malabsorption due to late radiation damage and small-bowel resection in order to document the aetiology of ileal dysfunction and to adjust therapeutic mamagement. In two patients with ileal resection up to 50 cm and in one patient without resection, a reduction of bowel motility by loperamide resulted in marked normalization of the {sup 75}Se-HCAT retention measurements. Sequential scintigraphic {sup 75}Se-HCAT imaging demonstrated a significant improvement in the {sup 75}Se-HCAT reabsorption and recirculation, accompanied in one case by prolongation of colonic retention of the radiopharmaceutical. In four patients with more than 80 cm resection, the {sup 75}Se-HCAT test was abnormal during loperamide administration. In two of these patients for whom baseline values were available, no improvement in the pattern of {sup 75}Se-HCAT absorption was observed. In conclusion, the first results of loperamide {sup 75}Se-HCAT in patients suspected of having bile acid malabsorption and abnormal baseline {sup 75}Se-HCAT are promising. Intervention with loperamide is easy and seems to improve the clinical value of the test with direct therapeutic implications. Sequential {sup 75}Se-HCAT imaging is essential for interpreting changes in the {sup 75}Se-HCAT retention measurements. (orig.).

  15. Comparative study on hematopoietic damage of mice caused by high-dose of gamma-ray irradiation

    International Nuclear Information System (INIS)

    Wu Hongying; Wang Yueying; Li Deguan; Wang Xiaochun; Zhang Heng; Lu Lu; Chang Jianhui; Du Liqing; Wang Yan; Men Aimin

    2010-01-01

    Objective: To study the effect of high-dose of gamma-ray irradiation on hematopoiesis injury and recovery of IRM-2 and C57BL/6 J mouse. Methods: The experiment was designed to study the effects of radiation (4 Gy) on spleen index, CFU-S and DNA damage on the 9 th day of IRM-2 and ICR mice and the effects of radiation (6 Gy) on WBC change and its absolute value on the 45 th days of IRM-2 and C57BL/6 J mice. Results: The IRM-2 mouse spleen index, CFU-S and DNA were higher than ICR mouse on the 9 th days, and there were significant difference in CFU-S and DNA (P<0.01). The IRM-2 mouse WBC, RMC, HGB and HCT were higher than C57BL/6 J mouse on the 45 th days, and there were significant difference (P<0.01). Conclusion: IRM-2 mouse hematopoiesis resumes quicker than C57BL/6 J and ICR do after high-dose of gamma-ray irradiation. (authors)

  16. Tissue Damage Caused by Myeloablative, but Not Non-Myeloablative, Conditioning before Allogeneic Stem Cell Transplantation Results in Dermal Macrophage Recruitment without Active T-Cell Interaction

    Directory of Open Access Journals (Sweden)

    Peter van Balen

    2018-02-01

    Full Text Available IntroductionConditioning regimens preceding allogeneic stem cell transplantation (alloSCT can cause tissue damage and acceleration of the development of graft-versus-host disease (GVHD. T-cell-depleted alloSCT with postponed donor lymphocyte infusion (DLI may reduce GVHD, because tissue injury can be restored at the time of DLI. In this study, we investigated the presence of tissue injury and inflammation in skin during the period of hematologic recovery and immune reconstitution after alloSCT.MethodsSkin biopsies were immunohistochemically stained for HLA class II, CD1a, CD11c, CD40, CD54, CD68, CD86, CD206, CD3, and CD8. HLA class II-expressing cells were characterized as activated T-cells, antigen-presenting cells (APCs, or tissue repairing macrophages. In sex-mismatched patient and donor couples, origin of cells was determined by multiplex analysis combining XY-FISH and fluorescent immunohistochemistry.ResultsNo inflammatory environment due to pretransplant conditioning was detected at the time of alloSCT, irrespective of the conditioning regimen. An increase in HLA class II-positive macrophages and CD3 T-cells was observed 12–24 weeks after myeloablative alloSCT, but these macrophages did not show signs of interaction with the co-localized T-cells. In contrast, during GVHD, an increase in HLA class II-expressing cells coinciding with T-cell interaction was observed, resulting in an overt inflammatory reaction with the presence of activated APC, activated donor T-cells, and localized upregulation of HLA class II expression on epidermal cells. In the absence of GVHD, patient derived macrophages were gradually replaced by donor-derived macrophages although patient-derived macrophages were detectable even 24 weeks after alloSCT.ConclusionConditioning regimens cause tissue damage in the skin, but this does not result in a local increase of activated APC. In contrast to the inflamed situation in GVHD, when interaction takes place between

  17. EFFICACY OF REMAXOL AND ADEMETHIONINE IN EXPERIMENTAL LIVER DAMAGE CAUSED BY A COMBINATION OF RESERVE-SERIES ANTITUBERCULOSIS DRUGS AND ALCOHOL

    Directory of Open Access Journals (Sweden)

    D. S. Sukhanov

    2014-01-01

    Full Text Available The hepatic and endothelial protective effects of remaxol and S-adenosyl-L-methionine were studied on 24 male rats with liver damage caused by reserve-series antituberculosis drugs in combination with alcohol. The test agents were found to have a unilateral hepatoprotective effect in decreasing the blood levels of triglycerides, bilirubin, and alkaline phosphatase with a concurrent significant reduction in the manifestations of hyaline-drop and hydropic dystrophy of hepatocytes. Remaxol and ademethionine have the same endothelial protective activity manifested as normalization of an endothelium-dependent vasodilation response and endothelial dysfunction coefficient.

  18. The role of zinc supplementation in the inhibition of tissue damage caused by exposure to electromagnetic field in rat lung and liver tissues.

    Science.gov (United States)

    Baltaci, A K; Mogulkoc, R; Salbacak, A; Celik, I; Sivrikaya, A

    2012-01-01

    The objective of the present study was to examine the effects of zinc supplementation on the oxidant damage in lung and liver tissues in rats exposed to a 50-Hz frequency magnetic field for 5 minutes every other day over a period of 6 months. The study included 24 adult male Sprague-Dawley rats, which were divided into the three groups in equal numbers: Group 1, the control group (G1); Group 2, the group exposed to an electromagnetic field (G2); and Group 3, the group, which was exposed to an EMF and supplemented with zinc (G3). At the end of the 6-month procedures, the animals were decapitated to collect lung and liver tissue samples, in which MDA was analyzed using the "TBARS method (nmol/g/protein)", GSH by the "biuret method (mg/g/protein)" and zinc levels by atomic emission (µg/dl). MDA levels in lung and liver tissues in G2 were higher than those in G1 and G3, and the levels in G3 were higher than those in G1 (pelectromagnetic field caused cellular damage in lung and liver tissues and zinc supplementation inhibited the inflicted cellular damage. Another important result of this study that needs emphasis was that exposure to an electromagnetic field led to a significant decrease in zinc levels in lung and liver tissues (Tab. 3, Ref. 23).

  19. Restoration of a historic church in the Rhineland brown coal mining area after damage caused by mining; Bergschadensanierung einer historischen Kirche im rheinischen Braunkohlenrevier

    Energy Technology Data Exchange (ETDEWEB)

    Koether, M. [Rheinbraun AG, Koeln (Germany); Weiper, H. [Rheinbraun AG, Koeln (Germany); Jung, H.H. [Ingenieurgesellschaft J.-F. und P. Jung und Partner GmbH, Gelsenkirchen (Germany)

    1996-09-01

    From the 1960s onwards, the Catholic parish curch of St. Remigius in Bergheim, the oldest parts of which date back to the 12th century, suffered damage caused by ground subsidences induced by mining operations on a tectonic fault. As a result of the effects of damage on the building over decades and the occurrence of a slip of almost 60 mm along the fault line, the damage to this National Trust edifice was so extensive by the late 1980s that the existence of the three-nave churche was seriously endangered in view of the further ground subsidences that were to be expected. (orig./HS) [Deutsch] Die katholische Pfarrkirche St. Remigius in Bergheim, deren aelteste Bauabschnitte aus dem 12. Jahrhundert stammen, wurde seit den 60er Jahren durch bergbaulich induzierte Bodenbewegungen an einer tektonischen Stoerung geschaedigt. Aufgrund der jahrzehntelangen Schadenseinwirkungen auf das Bauwerk und eine Absatzbildung an der Stoerungslinie von insgesamt fast 60 mm fuehrten Ende der 80er Jahre an dem denkmalgeschuetzten Bauwerk zu so starken Schaeden, dass der Bestand der dreischiffigen Kirche unter Beruecksichtigung der noch zu erwartenden Bodenbewegungen gefaehrdet war. (orig./HS)

  20. An economic assessment of the health effects and crop yield losses caused by air pollution in mainland China.

    Science.gov (United States)

    Miao, Weijie; Huang, Xin; Song, Yu

    2017-06-01

    Air pollution is severe in China, and pollutants such as PM 2.5 and surface O 3 may cause major damage to human health and crops, respectively. Few studies have considered the health effects of PM 2.5 or the loss of crop yields due to surface O 3 using model-simulated air pollution data in China. We used gridded outputs from the WRF-Chem model, high resolution population data, and crop yield data to evaluate the effects on human health and crop yield in mainland China. Our results showed that outdoor PM 2.5 pollution was responsible for 1.70-1.99 million cases of all-cause mortality in 2006. The economic costs of these health effects were estimated to be 151.1-176.9 billion USD, of which 90% were attributed to mortality. The estimated crop yield losses for wheat, rice, maize, and soybean were approximately 9, 4.6, 0.44, and 0.34 million tons, respectively, resulting in economic losses of 3.4 billion USD. The total economic losses due to ambient air pollution were estimated to be 154.5-180.3 billion USD, accounting for approximately 5.7%-6.6% of the total GDP of China in 2006. Our results show that both population health and staple crop yields in China have been significantly affected by exposure to air pollution. Measures should be taken to reduce emissions, improve air quality, and mitigate the economic loss. Copyright © 2016. Published by Elsevier B.V.

  1. Sociodemographic disparities associated with perceived causes of unmet need for mental health care.

    Science.gov (United States)

    Alang, Sirry M

    2015-12-01

    Mental disorders are among the leading causes of disability in the United States. In 2011, over 10 million adults felt that even though they needed treatment for mental health problems, they received insufficient or no mental health care and reported unmet need. This article assesses associations between sociodemographic characteristics and perceived causes of unmet needs for mental health care. A sample of 2,564 adults with unmet mental health need was obtained from the National Survey on Drug Use and Health. Outcome variables were 5 main reasons for unmet need: cost, stigma, minimization, low perceived treatment effectiveness, and structural barriers. Each cause of unmet need was regressed on sociodemographic, health, and service use characteristics. Women had higher odds of cost-related reasons for unmet need than men. Odds of stigma and structural barriers were greater among Blacks than Whites, and among rural than metropolitan residents. Compared with the uninsured, insured persons were less likely to report cost barriers. However, insured persons had higher odds of stigma and minimization of mental disorders. Insurance alone is unlikely to resolve the problem of unmet need. Understanding the social epidemiology of perceived unmet need will help identify populations at risk of not receiving mental health care or insufficient care. Focusing on specific programs and services that are designed to address the causes of perceived unmet need in particular populations is important. Future research should explore how intersecting social statuses affect the likelihood of perceived unmet need. (c) 2015 APA, all rights reserved).

  2. Using an extended 2D hydrodynamic model for evaluating damage risk caused by extreme rain events: Flash-Flood-Risk-Map (FFRM) Upper Austria

    Science.gov (United States)

    Humer, Günter; Reithofer, Andreas

    2016-04-01

    Using an extended 2D hydrodynamic model for evaluating damage risk caused by extreme rain events: Flash-Flood-Risk-Map (FFRM) Upper Austria Considering the increase in flash flood events causing massive damage during the last years in urban but also rural areas [1-4], the requirement for hydrodynamic calculation of flash flood prone areas and possible countermeasures has arisen to many municipalities and local governments. Besides the German based URBAS project [1], also the EU-funded FP7 research project "SWITCH-ON" [5] addresses the damage risk caused by flash floods in the sub-project "FFRM" (Flash Flood Risk Map Upper Austria) by calculating damage risk for buildings and vulnerable infrastructure like schools and hospitals caused by flash-flood driven inundation. While danger zones in riverine flooding are established as an integral part of spatial planning, flash floods caused by overland runoff from extreme rain events have been for long an underrated safety hazard not only for buildings and infrastructure, but man and animals as well. Based on the widespread 2D-model "hydro_as-2D", an extension was developed, which calculates the runoff formation from a spatially and temporally variable precipitation and determines two dimensionally the land surface area runoff and its concentration. The conception of the model is to preprocess the precipitation data and calculate the effective runoff-volume for a short time step of e.g. five minutes. This volume is applied to the nodes of the 2D-model and the calculation of the hydrodynamic model is started. At the end of each time step, the model run is stopped, the preprocessing step is repeated and the hydraulic model calculation is continued. In view of the later use for the whole of Upper Austria (12.000 km²) a model grid of 25x25 m² was established using digital elevation data. Model parameters could be estimated for the small catchment of river Ach, which was hit by an intense rain event with up to 109 mm per hour

  3. Decrease in the damage of powerful turbogenerator stator caused by vibration in the end zones (analysis, hypotheses, experiment

    Directory of Open Access Journals (Sweden)

    Yu.A. Shumilov

    2014-03-01

    Full Text Available The analysis of the turbogenerators’ TВВ-1000-2Y3 failure has shown that the most vulnerable link in the stator is such of their elements as tightening prisms, the teeth of the end packet core, lead-out and connecting buses of the stator winding. The basic reason for the destruction of the elements mentioned is metal fatigue caused by excessive vibration under the influence of variable axial forces of electromagnetic origin. Preventing the destruction of the structural elements may be achieved by vibration monitoring and diagnostics.

  4. Prevention of noise damages causes by shooting fire of Kalashnikov (AK-47) rifle by regulation of suitable distance

    OpenAIRE

    Gholamhossein Pourtaghi; Hamidreza Mokarami; Firouz Valipour; Mohammad Ghasemi

    2014-01-01

    The aims of this study were control of rifle shooting noise by regulation of suitable distance and investigation of frequency characteristic of the noise caused by single Kalashnikov rifle (AK-47) in an open shooting field. Due to the condition of the trainees and other people in the shooting fields, the measurements were done in 2 stages of individual and groups of 20 individuals and at 1, 30 and 50 meters distance, respectively. At each stage of the experiment the sound pressure level and p...

  5. Effect of silicon and nanosilicon on reduction of damage caused by salt stress in maize (Zea mays seedlings

    Directory of Open Access Journals (Sweden)

    Assieh Behdad

    2015-12-01

    Full Text Available Salinity reduced the efficiency of agricultural production like maize as one of the most important cereals for food and oil for humans. Silicon is the second most abundant element in the soil and alleviates the biotic and abiotic stresses in plants. The aim of this study is evaluate the effect of silicon and nanosilicon on improvement of salt stress in maize (Zea mays. For this propose, the interaction between the effects of different levels of salinity (0 and 100 mM, silicon and nanosilicon (50, 100 and 150 mg /mL was studied in completely randomized block design with factorial experiments and with three replications. The results showed that salinity significantly decreased root and shoot growth, amount of chlorophyll and carotenoid pigments, protein and potassium contents, compared to control. Treating plants with silicon and nanosilicon caused reduction of salinity effects and increase above indices. Salinity stress also caused a significant increase in proline, anthocyanin and soluble carbohydrate contents, lipid peroxidation, and catalase activity and treatment with silicon and nanosilicon alleviates effects of salt stress and reduced the amount of above indices. 150 mg/mL of nanosilicon showed the maximum effect on diminishing negative effects of salt stress on all examined parameters. So, the use of this element is proposed as alleviator of salt stress on maize.

  6. Damage of niobium surfaces caused by bombardment with 4He+ ions of different energies typical for T-20

    International Nuclear Information System (INIS)

    Guseva, M.I.; Gusev, V.; Martynenko, Yu.V.; Das, S.K.; Kaminsky, M.

    1979-01-01

    The aim of the present studies was to study surface damage due to blistering of both annealed and cold-worked niobium (a candidate first wall material for keV) irradiated sequentially with 4 He + ions with energies of 0.5 to 1800 keV for a total dose of 5.0 C/cm 2 . A typical surface of cold-worked Nb after irradiations with 4 He + ions with increasing energy from 0.5 to 90 keV is shown. The blister diameters range from 0.1 μm to 3 μm, and most of the blisters have exfoliated. The blisters fall into several size classes, the two most dominant ones having most probable blister diameters of approx. 0.27 μm and approx. 2.0 μm. The skin thickness of the larger blisters was measured to be approx. 0.23 μm. Also shown is the same area after irradiation with 150-1800-keV 4 He + irradiation for a dose of 0.66 C/cm 2 . A few additional blisters can be seen. A cold-worked Nb surface that was irradiated only with 150-1800-keV 4 He + ions is also shown. It is seen that prior irradiation with 0.5-90-keV 4 He + helped in significantly reducing blistering. For a total dose of 0.5 C/cm 2 , the erosion yield due to helium blistering of Nb ranges from (5.4 +- 2.0) x 10 -3 to (1.5 +- 0.7) x 10 -2 atoms/ion. For the cold-worked Nb target the results indicate clearly that the 4 He + implantations for the energy range from 0.5 to 90 keV help to reduce both the density and diameter of blisters formed by subsequent He-implantation for the energy ranging from 150 to 1800 keV. 2 figures

  7. Identification of Causes of the Occupational Stress for Health Providers at Different Levels of Health Care.

    Science.gov (United States)

    Trifunovic, Natasa; Jatic, Zaim; Kulenovic, Alma Dzubur

    2017-06-01

    To identify and compare the stressors in the work environment experienced by employees in primary health care and secondary health care, amongphysiciansand nurses. The survey was conducted to identify types of stressors by assessing health care workers employed in the primary and secondary health care services of the Public Institution, the Health Centre of the Sarajevo Canton, using a questionnaire about stress in the workplace. Among all study participants stressors connected to the organization of work, finance and communication were found to affect their mental health most strongly. The results show a significant difference between primary and secondary health care in experience of stressors related to the organization of work, communication, and stressors related to the emotional and physical risks. Primary health care physicians report a significantly higher experience of stress and impact on mental health compared with other physicians related to emotional difficulties when working in the field of palliative care. Our results also indicate a significant difference between primary and secondary health providers in experiencing stressors related to the organization of work, such as: on-call duty shifts, an inadequate working environment and in the assessment of administrative work overload. The survey identified the most intense stressors for doctors and nurses at primary and secondary levels of health care services. The results of the study indicate that doctors and nurses have a different hierarchy of stressors, as well as subjects at Primary and Secondary Health Care. The results of the study indicate that subjects et Primary Health Care perceive more stressful organizational, emotional and communicational problems.

  8. Analysis of the causes and recommendations on elimination of biological damage of structures during the repair and reconstruction of the State Biological Museum in Moscow.

    Directory of Open Access Journals (Sweden)

    Kamskov Victor

    2017-01-01

    Full Text Available The article presents the results of mycological research on buildings of the State Biological Museum located in Moscow. The problems have been considered as for a complex of buildings of the State Biological Museum built in the late nineteenth century which, to the present time, has been operated almost in its original form. Over time, the building maintenance conditions have worsened, in particular because of construction of high-rise buildings in the immediate vicinity of the museum, as well as construction of a greenhouse above the underground passage tunnel between buildings 1 and 2. Over the years, the temperature gradients, high humidity, wear and damage of wall waterproofing and foundations have caused leaks in the underpass tunnel and the biological corrosion of stone, wood and metal structures in indoor exhibition halls. In this connection, part of the survey was to determine the types and size of biological lesions in structures, determination of the causes of biological damage, and the development of measures to eliminate the mycological problems during repair and reconstruction works in the museum.

  9. The cancer-germline antigen SSX2 causes cell cycle arrest and DNA damage in cancer cells

    DEFF Research Database (Denmark)

    Greve, Katrine Buch Vidén; Lindgreen, Jonas; Terp, Mikkel Green

    2011-01-01

    The SSX family of cancer and germline antigens is mainly expressed in the germ cells of healthy individuals as well as wide range of cancers and is therefore potential targets for immunotherapy. However, little is known about the role of SSX proteins in tumorigenesis and normal cell function. Here......, we show that SSX2 is involved in regulation of cancer cell growth. We found that ectopic expression of SSX2 in melanoma and colon cancer cells strongly reduced cell growth and induced apoptosis in vitro. Importantly, in a xenograft mouse model, the growth of tumors derived from SSX2 overexpressing...... melanoma cells was severely reduced compared to those derived from the isogenic parental cell line. Cell cycle analysis showed that SSX2 caused an accumulation of cells arrested in G1. Consistent with this, we observed a marked decrease in cells expressing the proliferation marker Ki67 and concomitantly...

  10. Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice

    Directory of Open Access Journals (Sweden)

    Isabela Finamor

    2017-04-01

    Full Text Available No-caloric sweeteners, such as aspartame, are widely used in various food and beverages to prevent the increasing rates of obesity and diabetes mellitus, acting as tools in helping control caloric intake. Aspartame is metabolized to phenylalanine, aspartic acid, and methanol. Our aim was to study the effect of chronic administration of aspartame on glutathione redox status and on the trans-sulphuration pathway in mouse liver. Mice were divided into three groups: control; treated daily with aspartame for 90 days; and treated with aspartame plus N-acetylcysteine (NAC. Chronic administration of aspartame increased plasma alanine aminotransferase (ALT and aspartate aminotransferase activities and caused liver injury as well as marked decreased hepatic levels of reduced glutathione (GSH, oxidized glutathione (GSSG, γ-glutamylcysteine ​​(γ-GC, and most metabolites of the trans-sulphuration pathway, such as cysteine, S-adenosylmethionine (SAM, and S-adenosylhomocysteine ​​(SAH. Aspartame also triggered a decrease in mRNA and protein levels of the catalytic subunit of glutamate cysteine ligase (GCLc and cystathionine γ-lyase, and in protein levels of methionine adenosyltransferase 1A and 2A. N-acetylcysteine prevented the aspartame-induced liver injury and the increase in plasma ALT activity as well as the decrease in GSH, γ-GC, cysteine, SAM and SAH levels and GCLc protein levels. In conclusion, chronic administration of aspartame caused marked hepatic GSH depletion, which should be ascribed to GCLc down-regulation and decreased cysteine levels. Aspartame triggered blockade of the trans-sulphuration pathway at two steps, cystathionine γ-lyase and methionine adenosyltransferases. NAC restored glutathione levels as well as the impairment of the trans-sulphuration pathway.

  11. Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice.

    Science.gov (United States)

    Finamor, Isabela; Pérez, Salvador; Bressan, Caroline A; Brenner, Carlos E; Rius-Pérez, Sergio; Brittes, Patricia C; Cheiran, Gabriele; Rocha, Maria I; da Veiga, Marcelo; Sastre, Juan; Pavanato, Maria A

    2017-04-01

    No-caloric sweeteners, such as aspartame, are widely used in various food and beverages to prevent the increasing rates of obesity and diabetes mellitus, acting as tools in helping control caloric intake. Aspartame is metabolized to phenylalanine, aspartic acid, and methanol. Our aim was to study the effect of chronic administration of aspartame on glutathione redox status and on the trans-sulphuration pathway in mouse liver. Mice were divided into three groups: control; treated daily with aspartame for 90 days; and treated with aspartame plus N-acetylcysteine (NAC). Chronic administration of aspartame increased plasma alanine aminotransferase (ALT) and aspartate aminotransferase activities and caused liver injury as well as marked decreased hepatic levels of reduced glutathione (GSH), oxidized glutathione (GSSG), γ-glutamylcysteine ​​(γ-GC), and most metabolites of the trans-sulphuration pathway, such as cysteine, S-adenosylmethionine (SAM), and S-adenosylhomocysteine ​​(SAH). Aspartame also triggered a decrease in mRNA and protein levels of the catalytic subunit of glutamate cysteine ligase (GCLc) and cystathionine γ-lyase, and in protein levels of methionine adenosyltransferase 1A and 2A. N-acetylcysteine prevented the aspartame-induced liver injury and the increase in plasma ALT activity as well as the decrease in GSH, γ-GC, cysteine, SAM and SAH levels and GCLc protein levels. In conclusion, chronic administration of aspartame caused marked hepatic GSH depletion, which should be ascribed to GCLc down-regulation and decreased cysteine levels. Aspartame triggered blockade of the trans-sulphuration pathway at two steps, cystathionine γ-lyase and methionine adenosyltransferases. NAC restored glutathione levels as well as the impairment of the trans-sulphuration pathway. Copyright © 2017. Published by Elsevier B.V.

  12. Social inequalities in causes of death amenable to health care in Norway

    Directory of Open Access Journals (Sweden)

    Camilla Hem

    2007-01-01

    Full Text Available Objective: Investigate if there are educational inequalities in causes of death considered amenable to health care in Norway and compare this with non-amenable causes. Methods: The study used the concept of “amenable mortality”, which here includes 34 specific causes of death. A linked data file, with information from the Norwegian Causes of Death Registry and the Educational Registry was analyzed. The study population included the whole Norwegian population in two age groups of interest (25-49 and 50-74 years. Information on deaths was from the period 1990-2001. Education was recorded in 1990 and it was grouped in four categories as: basic, lower secondary, higher secondary and higher. In the study men and women were analysed seperately. The analysis was conducted for all amenable causes pooled with and without ischemic heart disease. A Cox proportional hazard regression model was fitted to estimate hazard rate ratios. Results: The study showed educational differences in mortality from causes of death considered amenable to health care, in both age groups and sexes. This was seen both when including and excluding ischemic heart disease. The effect sizes were comparable for amenable and non-amenable causes in both age groups and sexes. Conclusions: This study revealed systematic higher risk of death in lower educational groups in causes of death considered amenable to health care. This indicates potential weaknesses in equitable provision of health care for the Norwegian population. Additional research is needed to identify domains within the health care system of particular concern.

  13. Impact of weight change after quitting cigarettes on all-cause and cause-specific mortality in middle-aged male smokers: national health screening cohort study

    OpenAIRE

    Kyuwoong Kim; Seulggie Choi; Mi Hee Cho; Ji Hye Jun; Jooyoung Chang; Sung Min Kim; Kiheon Lee; Sang Min Park

    2018-01-01

    Background We aimed to investigate the association between weight change after smoking cessation and the risk of all-cause and cause-specific mortality among middle-aged male smokers. Methods We conducted a prospective cohort study using the National Health Insurance Service National Health Screening Cohort (NHIS-HealS) database. Male Participants (n=102,403) without critical conditions aged between 40 and 79 at baseline who underwent biennial health examination ...

  14. Zika virus infection in immunocompetent pregnant mice causes fetal damage and placental pathology in the absence of fetal infection

    Science.gov (United States)

    Kummer, Lawrence W.; Lanthier, Paula; Kim, In-Jeong; Kuki, Atsuo; Thomas, Stephen J.

    2018-01-01

    Zika virus (ZIKV) infection during human pregnancy may cause diverse and serious congenital defects in the developing fetus. Previous efforts to generate animal models of human ZIKV infection and clinical symptoms often involved manipulating mice to impair their Type I interferon (IFN) signaling, thereby allowing enhanced infection and vertical transmission of virus to the embryo. Here, we show that even pregnant mice competent to generate Type I IFN responses that can limit ZIKV infection nonetheless develop profound placental pathology and high frequency of fetal demise. We consistently found that maternal ZIKV exposure led to placental pathology and that ZIKV RNA levels measured in maternal, placental or embryonic tissues were not predictive of the pathological effects seen in the embryos. Placental pathology included trophoblast hyperplasia in the labyrinth, trophoblast giant cell necrosis in the junctional zone, and loss of embryonic vessels. Our findings suggest that, in this context of limited infection, placental pathology rather than embryonic/fetal viral infection may be a stronger contributor to adverse pregnancy outcomes in mice. Our finding demonstrates that in immunocompetent mice, direct viral infection of the embryo is not essential for fetal demise. Our immunologically unmanipulated pregnancy mouse model provides a consistent and easily measurable congenital abnormality readout to assess fetal outcome, and may serve as an additional model to test prophylactic and therapeutic interventions to protect the fetus during pregnancy, and for studying the mechanisms of ZIKV congenital immunopathogenesis. PMID:29634758

  15. Fetal and neonatal nicotine exposure in Wistar rats causes progressive pancreatic mitochondrial damage and beta cell dysfunction.

    Directory of Open Access Journals (Sweden)

    Jennifer E Bruin

    Full Text Available Nicotine replacement therapy (NRT is currently recommended as a safe smoking cessation aid for pregnant women. However, fetal and neonatal nicotine exposure in rats causes mitochondrial-mediated beta cell apoptosis at weaning, and adult-onset dysglycemia, which we hypothesize is related to progressive mitochondrial dysfunction in the pancreas. Therefore in this study we examined the effect of fetal and neonatal exposure to nicotine on pancreatic mitochondrial structure and function during postnatal development. Female Wistar rats were given saline (vehicle control or nicotine bitartrate (1 mg/kg/d via subcutaneous injection for 2 weeks prior to mating until weaning. At 3-4, 15 and 26 weeks of age, oral glucose tolerance tests were performed, and pancreas tissue was collected for electron microscopy, enzyme activity assays and islet isolation. Following nicotine exposure mitochondrial structural abnormalities were observed beginning at 3 weeks and worsened with advancing age. Importantly the appearance of these structural defects in nicotine-exposed animals preceded the onset of glucose intolerance. Nicotine exposure also resulted in significantly reduced pancreatic respiratory chain enzyme activity, degranulation of beta cells, elevated islet oxidative stress and impaired glucose-stimulated insulin secretion compared to saline controls at 26 weeks of age. Taken together, these data suggest that maternal nicotine use during pregnancy results in postnatal mitochondrial dysfunction that may explain, in part, the dysglycemia observed in the offspring from this animal model. These results clearly indicate that further investigation into the safety of NRT use during pregnancy is warranted.

  16. Causes and determinants of inequity in maternal and child health in Vietnam

    Directory of Open Access Journals (Sweden)

    Målqvist Mats

    2012-08-01

    Full Text Available Abstract Background Inequities in health are a major challenge for health care planners and policymakers globally. In Vietnam, rapid societal development presents a considerable risk for disadvantaged populations to be left behind. The aim of this review is to map the known causes and determinants of inequity in maternal and child health in Vietnam in order to promote policy action. Methods A review was performed through systematic searches of Pubmed and Proquest and manual searches of “grey literature.” A thematic content analysis guided by the conceptual framework suggested by the Commission on Social Determinants of Health was performed. Results More than thirty different causes and determinants of inequity in maternal and child health were identified. Some determinants worth highlighting were the influence of informal fees and the many testimonies of discrimination and negative attitudes from health staff towards women in general and ethnic minorities in particular. Research gaps were identified, such as a lack of studies investigating the influence of education on health care utilization, informal costs of care, and how psychosocial factors mediate inequity. Conclusions The evidence of corruption and discrimination as mediators of health inequity in Vietnam calls for attention and indicates a need for more structural interventions such as better governance and anti-discriminatory laws. More research is needed in order to fully understand the pathways of inequities in health in Vietnam and suggest areas for intervention for policy action to reach disadvantaged populations.

  17. Causes and determinants of inequity in maternal and child health in Vietnam.

    Science.gov (United States)

    Målqvist, Mats; Hoa, Dinh Thi Phuong; Thomsen, Sarah

    2012-08-11

    Inequities in health are a major challenge for health care planners and policymakers globally. In Vietnam, rapid societal development presents a considerable risk for disadvantaged populations to be left behind. The aim of this review is to map the known causes and determinants of inequity in maternal and child health in Vietnam in order to promote policy action. A review was performed through systematic searches of Pubmed and Proquest and manual searches of "grey literature." A thematic content analysis guided by the conceptual framework suggested by the Commission on Social Determinants of Health was performed. More than thirty different causes and determinants of inequity in maternal and child health were identified. Some determinants worth highlighting were the influence of informal fees and the many testimonies of discrimination and negative attitudes from health staff towards women in general and ethnic minorities in particular. Research gaps were identified, such as a lack of studies investigating the influence of education on health care utilization, informal costs of care, and how psychosocial factors mediate inequity. The evidence of corruption and discrimination as mediators of health inequity in Vietnam calls for attention and indicates a need for more structural interventions such as better governance and anti-discriminatory laws. More research is needed in order to fully understand the pathways of inequities in health in Vietnam and suggest areas for intervention for policy action to reach disadvantaged populations.

  18. Passion for a Cause: How It Affects Health and Subjective Well-Being.

    Science.gov (United States)

    St-Louis, Ariane C; Carbonneau, Noémie; Vallerand, Robert J

    2016-06-01

    Using the dualistic model of passion (Vallerand et al., 2003), this research investigated how harmonious passion (HP) or obsessive passion (OP) for a cause can affect volunteers' health and subjective well-being. Three studies with volunteers for local (local emergency crises and community help) and international (humanitarian missions) causes assessed physical and psychological health using cross-sectional and longitudinal designs. Study 1 (N = 108) showed that HP was positively related to satisfaction with one's involvement in the cause and unrelated to physical injuries due to cause involvement. OP was unrelated to satisfaction but positively associated with injuries. Findings were replicated in Study 2 (N = 83). Moreover, self-neglect mediated the positive and negative effects of HP and OP, respectively, on injuries. Study 3 (N = 77) revealed that HP predicted an increase in satisfaction and health over a 3-month mission. OP predicted an increase in physical symptoms and a decrease in health. Furthermore, OP before a mission was positively related to self-neglect that was positively associated with physical symptoms after a mission. OP also positively predicted rumination that was conducive to posttraumatic stress disorder. HP was unrelated to these variables. Findings underscore the role of passion for a cause in predicting intrapersonal outcomes of volunteers. © 2014 Wiley Periodicals, Inc.

  19. Intelligence: is it the epidemiologists' elusive "fundamental cause" of social class inequalities in health?

    Science.gov (United States)

    Gottfredson, Linda S

    2004-01-01

    Virtually all indicators of physical health and mental competence favor persons of higher socioeconomic status (SES). Conventional theories in the social sciences assume that the material disadvantages of lower SES are primarily responsible for these inequalities, either directly or by inducing psychosocial harm. These theories cannot explain, however, why the relation between SES and health outcomes (knowledge, behavior, morbidity, and mortality) is not only remarkably general across time, place, disease, and kind of health system but also so finely graded up the entire SES continuum. Epidemiologists have therefore posited, but not yet identified, a more general "fundamental cause" of health inequalities. This article concatenates various bodies of evidence to demonstrate that differences in general intelligence (g) may be that fundamental cause.

  20. Development of a wireless, self-sustaining damage detection sensor system based on chemiluminescence for structural health monitoring

    Science.gov (United States)

    Kuang, K. S. C.

    2014-03-01

    A novel application of chemiluminescence resulting from the chemical reaction in a glow-stick as sensors for structural health monitoring is demonstrated here. By detecting the presence of light emitting from these glow-sticks, it is possible to develop a low-cost sensing device with the potential to provide early warning of damage in a variety of engineering applications such as monitoring of cracks or damage in concrete shear walls, detecting of ground settlement, soil liquefaction, slope instability, liquefaction-related damage of underground structure and others. In addition, this paper demonstrates the ease of incorporating wireless capability to the sensor device and the possibility of making the sensor system self-sustaining by means of a renewable power source for the wireless module. A significant advantage of the system compared to previous work on the use of plastic optical fibre (POF) for damage detection is that here the system does not require an electrically-powered light source. Here, the sensing device, embedded in a cement host, is shown to be capable of detecting damage. A series of specimens with embedded glow-sticks have been investigated and an assessment of their damage detection capability will be reported. The specimens were loaded under flexure and the sensor responses were transmitted via a wireless connection.

  1. Damage Evaluation and Analysis of Composite Pressure Vessels Using Fiber Bragg Gratings to Determine Structural Health

    National Research Council Canada - National Science Library

    Kunzler, Marley; Udd, Eric; Kreger, Stephen; Johnson, Mont; Henrie, Vaughn

    2005-01-01

    .... Using fiber Bragg gratings embedded into the weave structure of carbon fiber epoxy composites allow the capability to monitor these composites during manufacture, cure, general aging, and damage...

  2. How Thailand's greater convergence created sustainable funding for emerging health priorities caused by globalization

    Science.gov (United States)

    Charoenca, Naowarut; Kungskulniti, Nipapun; Mock, Jeremiah; Hamann, Stephen; Vathesatogkit, Prakit

    2015-01-01

    Background Global health is shifting gradually from a limited focus on individual communicable disease goals to the formulation of broader sustainable health development goals. A major impediment to this shift is that most low- and middle-income countries (LMICs) have not established adequate sustainable funding for health promotion and health infrastructure. Objective In this article, we analyze how Thailand, a middle-income country, created a mechanism for sustainable funding for health. Design We analyzed the progression of tobacco control and health promotion policies over the past three decades within the wider political-economic and sociocultural context. We constructed a parallel longitudinal analysis of statistical data on one emerging priority – road accidents – to determine whether policy shifts resulted in reduced injuries, hospitalizations and deaths. Results In Thailand, the convergence of priorities among national interest groups for sustainable health development created an opportunity to use domestic tax policy and to create a semi-autonomous foundation (ThaiHealth) to address a range of pressing health priorities, including programs that substantially reduced road accidents. Conclusions Thailand's strategic process to develop a domestic mechanism for sustainable funding for health may provide LMICs with a roadmap to address emerging health priorities, especially those caused by modernization and globalization. PMID:26328948

  3. How Thailand's greater convergence created sustainable funding for emerging health priorities caused by globalization.

    Science.gov (United States)

    Charoenca, Naowarut; Kungskulniti, Nipapun; Mock, Jeremiah; Hamann, Stephen; Vathesatogkit, Prakit

    2015-01-01

    Global health is shifting gradually from a limited focus on individual communicable disease goals to the formulation of broader sustainable health development goals. A major impediment to this shift is that most low- and middle-income countries (LMICs) have not established adequate sustainable funding for health promotion and health infrastructure. In this article, we analyze how Thailand, a middle-income country, created a mechanism for sustainable funding for health. We analyzed the progression of tobacco control and health promotion policies over the past three decades within the wider political-economic and sociocultural context. We constructed a parallel longitudinal analysis of statistical data on one emerging priority - road accidents - to determine whether policy shifts resulted in reduced injuries, hospitalizations and deaths. In Thailand, the convergence of priorities among national interest groups for sustainable health development created an opportunity to use domestic tax policy and to create a semi-autonomous foundation (ThaiHealth) to address a range of pressing health priorities, including programs that substantially reduced road accidents. Thailand's strategic process to develop a domestic mechanism for sustainable funding for health may provide LMICs with a roadmap to address emerging health priorities, especially those caused by modernization and globalization.

  4. How Thailand's greater convergence created sustainable funding for emerging health priorities caused by globalization

    Directory of Open Access Journals (Sweden)

    Naowarut Charoenca

    2015-08-01

    Full Text Available Background: Global health is shifting gradually from a limited focus on individual communicable disease goals to the formulation of broader sustainable health development goals. A major impediment to this shift is that most low- and middle-income countries (LMICs have not established adequate sustainable funding for health promotion and health infrastructure. Objective: In this article, we analyze how Thailand, a middle-income country, created a mechanism for sustainable funding for health. Design: We analyzed the progression of tobacco control and health promotion policies over the past three decades within the wider political-economic and sociocultural context. We constructed a parallel longitudinal analysis of statistical data on one emerging priority – road accidents – to determine whether policy shifts resulted in reduced injuries, hospitalizations and deaths. Results: In Thailand, the convergence of priorities among national interest groups for sustainable health development created an opportunity to use domestic tax policy and to create a semi-autonomous foundation (ThaiHealth to address a range of pressing health priorities, including programs that substantially reduced road accidents. Conclusions: Thailand's strategic process to develop a domestic mechanism for sustainable funding for health may provide LMICs with a roadmap to address emerging health priorities, especially those caused by modernization and globalization.

  5. Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line

    International Nuclear Information System (INIS)

    Li Hui; Berlo, Damien van; Shi Tingming; Speit, Guenter; Knaapen, Ad M.; Borm, Paul J.A.; Albrecht, Catrin; Schins, Roel P.F.

    2008-01-01

    Chronic inhalation of high concentrations of respirable quartz particles has been implicated in various lung diseases including lung fibrosis and cancer. Generation of reactive oxygen species (ROS) and oxidative stress is considered a major mechanism of quartz toxicity. Curcumin, a yellow pigment from Curcuma longa, has been considered as nutraceutical because of its strong anti-inflammatory, antitumour and antioxidant properties. The aim of our present study was to investigate whether curcumin can protect lung epithelial cells from the cytotoxic, genotoxic and inflammatory effects associated with quartz (DQ12) exposure. Electron paramagnetic resonance (EPR) measurements using the spin-trap DMPO demonstrated that curcumin reduces hydrogen peroxide-dependent hydroxyl-radical formation by quartz. Curcumin was also found to reduce quartz-induced cytotoxicity and cyclooxygenase 2 (COX-2) mRNA expression in RLE-6TN rat lung epithelial cells (RLE). Curcumin also inhibited the release of macrophage inflammatory protein-2 (MIP-2) from RLE cells as observed upon treatment with interleukin-1 beta (IL-1β) and tumour necrosis factor-alpha (TNFα). However, curcumin failed to protect the RLE cells from oxidative DNA damage induced by quartz, as shown by formamidopyrimidine glycosylase (FPG)-modified comet assay and by immunocytochemistry for 8-hydroxydeoxyguanosine. In contrast, curcumin was found to be a strong inducer of oxidative DNA damage itself at non-cytotoxic and anti-inflammatory concentrations. In line with this, curcumin also enhanced the mRNA expression of the oxidative stress response gene heme oxygenase-1 (ho-1). Curcumin also caused oxidative DNA damage in NR8383 rat alveolar macrophages and A549 human lung epithelial cells. Taken together, these observations indicate that one should be cautious in considering the potential use of curcumin in the prevention or treatment of lung diseases associated with quartz exposure

  6. Regionalized life cycle impact assessment of air pollution on the global scale: Damage to human health and vegetation

    Science.gov (United States)

    van Zelm, Rosalie; Preiss, Philipp; van Goethem, Thomas; Van Dingenen, Rita; Huijbregts, Mark

    2016-06-01

    We developed regionalized characterization factors (CFs) for human health damage from particulate matter (PM2.5) and ozone, and for damage to vegetation from ozone, at the global scale. These factors can be used in the impact assessment phase of an environmental life cycle assessment. CFs express the overall damage of a certain pollutant per unit of emission of a precursor, i.e. primary PM2.5, nitrogen oxides (NOx), ammonia (NH3), sulfur dioxide (SO2) and non-methane volatile organic compounds (NMVOCs). The global chemical transport model TM5 was used to calculate intake fractions of PM2.5 and ozone for 56 world regions covering the whole globe. Furthermore, region-specific effect and damage factors were derived, using mortality rates, background concentrations and years of life lost. The emission-weighted world average CF for primary PM2.5 emissions is 629 yr kton-1, varying up to 3 orders of magnitude over the regions. Larger CFs were obtained for emissions in central Asia and Europe, and smaller factors in Australia and South America. The world average CFs for PM2.5 from secondary aerosols, i.e. NOx, NH3, and SO2, is 67.2 to 183.4 yr kton-1. We found that the CFs for ozone human health damage are 2-4 orders of magnitude lower compared to the CFs for damage due to primary PM2.5 and PM2.5 precursor emissions. Human health damage due to the priority air pollutants considered in this study was 1.7·10-2 yr capita-1 worldwide in year 2010, with primary PM2.5 emissions as the main contributor (62%). The emission-weighted world average CF for ecosystem damage due to ozone was 2.5 km2 yr kton-1 for NMVOCs and 8.7 m2 yr kg-1 for NOx emissions, varying 2-3 orders of magnitude over the regions. Ecosystem damage due to the priority air pollutants considered in this study was 1.6·10-4 km2 capita-1 worldwide in 2010, with NOx as the main contributor (72%). The spatial range in CFs stresses the importance of including spatial variation in life cycle impact assessment of

  7. [A sense of responsibility in health personnel as a cause of work-related stress].

    Science.gov (United States)

    Nedić, Olesja; Jocić, Neda; Filipović, Danka; Solak, Zdravko

    2002-01-01

    Job stress is a great problem in developed countries of the world, but in Yugoslavia, it is increased due to additional reasons associated with economic crisis in the society. Health services and health workers are in particularly difficult conditions. The aim of this paper was to examine sources and causes of job stress in health workers. The research was undertaken among health workers treated at Health Centre "Hospital" in Novi Sad. The study group included health workers--doctors, nurses and laboratory workers, and the control group included the rest of non-medical staff. Adapted Siegrist questionnaire was used. Three factors were examined: extrinsic efforts (disturbances at work, sense of great job responsibility and the need for overtime work); intrinsinc efforts (major criticism, thinking about the job from the early morning, getting nervous because of minor problems, discontentment because of unsolved problems at work, relaxation at home and so on), and low reward (respect from the superiors and colleagues, support and security at workplace). Answers were scored indicating intensity (high, moderate, low, not at all). Statistic analysis included testing the level of significance in health workers in relation to non-medical staff (t test and Fisher's exact test). Applying the scoring system it has been established that health workers are exposed to greater job stress, great sense of very high job responsibility and frequent overtime work (p stress increases absenteeism, reduces work productivity, causes higher expenses of medical treatment, rehabilitation and staff retraining. It is of great importance to identify factors which cause job dissatisfaction in order to decrease them to the lowest level. High sense of responsibility in health workers is a course of job stress.

  8. Meat Intake and the Dose of Vitamin B – Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?

    Directory of Open Access Journals (Sweden)

    Lisa J Hill

    2017-05-01

    Full Text Available Meat and vitamin B 3 – nicotinamide – intake was high during hunter-gatherer times. Intake then fell and variances increased during and after the Neolithic agricultural revolution. Health, height, and IQ deteriorated. Low dietary doses are buffered by ‘welcoming’ gut symbionts and tuberculosis that can supply nicotinamide, but this co-evolved homeostatic metagenomic strategy risks dysbioses and impaired resistance to pathogens. Vitamin B 3 deficiency may now be common among the poor billions on a low-meat diet. Disease transitions to non-communicable inflammatory disorders (but longer lives may be driven by positive ‘meat transitions’. High doses of nicotinamide lead to reduced regulatory T cells and immune intolerance. Loss of no longer needed symbiotic ‘old friends’ compounds immunological over-reactivity to cause allergic and auto-immune diseases. Inhibition of nicotinamide adenine dinucleotide consumers and loss of methyl groups or production of toxins may cause cancers, metabolic toxicity, or neurodegeneration. An optimal dosage of vitamin B 3 could lead to better health, but such a preventive approach needs more equitable meat distribution. Some people may require personalised doses depending on genetic make-up or, temporarily, when under stress.

  9. Damages and causes of death in plantations with containerised seedlings of Scots pine and Norway spruce in the central of Sweden

    Energy Technology Data Exchange (ETDEWEB)

    Naumburg, Jan

    2000-07-01

    In 1972, 94 forest areas were planted with containerised seedlings, 83 with Scots pine (Pinus sylvestris L.) and 11 with Norway spruce (Picea abies (L.) Karst.), in the central of Sweden. In the first season after planting, 99% of the Scots pine and 98% of the Norway spruce seedlings survived. Three seasons after plantation, 67% of Scots pine and 62% of Norway spruce were alive. The most common type of known damages causing mortality were mammals and insects. Vegetation was registered as the cause of mortality at some occasions in Scots pine plantations, whereas vegetation never was considered as the cause of death in Norway spruce plantations. The average size of the scarification patches were 0.25 m{sup 2} and 0.4 m{sup 2} in Scots pine and Norway spruce respectively. In Scots pine plantations there were 1600 planted seedlings ha{sup -1} and in Norway spruce there were 1550 ha{sup -1}. After the third growing season, the numbers of main crop plants, including naturally regenerated hardwood and softwood plants, were 1500 ha{sup -1} for Scots pine and 1350 ha{sup -1} for Norway spruce. The studied plantings had been approved if the recommended number of seedlings had been planted. As there always is some mortality among planted seedlings, in the present study 35-40%, this phenomenon has to be taken into consideration when dimensioning the number of seedlings which are to be planted.

  10. Oxidative stress and DNA damage caused by the urban air pollutant 3-NBA and its isomer 2-NBA in human lung cells analyzed with three independent methods.

    Science.gov (United States)

    Nagy, Eszter; Johansson, Clara; Zeisig, Magnus; Möller, Lennart

    2005-11-15

    The air pollutant 3-nitrobenzanthrone (3-NBA), emitted in diesel exhaust, is a potent mutagen and genotoxin. 3-NBA can isomerise to 2-nitrobenzanthrone (2-NBA), which can become more than 70-fold higher in concentration in ambient air. In this study, three independent methods have been employed to evaluate the oxidative stress and genotoxicity of 2-NBA compared to 3-NBA in the human A549 lung cell line. HPLC-EC/UV was applied for measurements of oxidative damage in the form of 8-oxo-2'-deoxyguanosine (8-oxodG), (32)P-HPLC for measurements of lipophilic DNA-adducts, and the Comet assay to measure a variety of DNA lesions, including oxidative stress. No significant oxidative damage from either isomer was found regarding formation of 8-oxodG analysed using HPLC-EC/UV. However, the Comet assay (with FPG-treatment), which is more sensitive and detects more types of damages compared to HPLC-EC/UV, showed a significant effect from both 3-NBA and 2-NBA. (32)P-HPLC revealed a strong DNA-adduct formation from both 3-NBA and 2-NBA, and also a significant difference between both isomers compared to negative control. These results clearly show that 2-NBA has a genotoxic potential. Even if the DNA-adduct forming capacity and the amount of DNA lesions measured with the (32)P-HPLC and Comet assay is about one third of 3-NBA, the high abundance of 2-NBA in ambient air calls for further investigation and evaluation of its health hazard.

  11. Probability estimation of potential harm to human health and life caused by a hypothetical nuclear accident at the nuclear power plant

    International Nuclear Information System (INIS)

    Soloviov, Vladyslav; Pysmenniy, Yevgen

    2015-01-01

    This paper describes some general methodological aspects of the assessment of the damage to human life and health caused by a hypothetical nuclear accident at the nuclear power plant (NPP). Probability estimation of death (due to cancer and non-cancer effects of radiation injury), disability and incapacity of individuals were made by taking into account the regulations of Ukraine. According to the assessment, the probability of death due to cancer and non-cancer effects of radiation damage to individuals who received radiation dose of 1 Sv is equal to 0.09. Probability of disability of 1, 2 or 3 group regardless of the radiation dose is 0.009, 0.0054, 0.027, respectively. Probability of temporary disability of the individual who received dose equal to 33 mSv (the level of potential exposure in a hypothetical nuclear accident at the NPP) is equal 0.16. This probability estimation of potential harm to human health and life caused by a hypothetical nuclear accident can be used for NPP in different countries using requirements of regulations in these countries. And also to estimate the amount of insurance payments due to the nuclear damage in the event of a nuclear accident at the NPP or other nuclear industry enterprise. (author)

  12. Pre-anthesis high-temperature acclimation alleviates damage to the flag leaf caused by post-anthesis heat stress in wheat

    DEFF Research Database (Denmark)

    Wang, Xiao; Cai, Jian; Jian, Dong

    2011-01-01

    and enhanced cell membrane peroxidation, as exemplified by increased O2-• production rate and reduction in activities of antioxiditave enzymes. However, under post-anthesis heat stress, plants with pre-anthesis hightemperature acclimation (HH)showedmuchhigher photosynthetic rates than those without pre...... all up-regulated under HH, whereas a gene encoding a major chlorophyll a/b-binding protein (Cab) was up-regulated by post-anthesis heat stress at 10 DAA, but was down-regulated at 13 DAA. The changes in the expression levels of the HH plants were more pronounced than those for the CH. Collectively......, the results indicated that pre-anthesis high-temperature acclimation could effectively alleviate the photosynthetic and oxidative damage caused by post-anthesis heat stress in wheat flag leaves, which was partially attributable to modifications in the expression of the photosythesis-responsive and antioxidant...

  13. Estimating the willingness to pay to protect coral reefs from potential damage caused by climate change--The evidence from Taiwan.

    Science.gov (United States)

    Tseng, William Wei-Chun; Hsu, Shu-Han; Chen, Chi-Chung

    2015-12-30

    Coral reefs constitute the most biologically productive and diverse ecosystem, and provide various goods and services including those related to fisheries, marine tourism, coastal protection, and medicine. However, they are sensitive to climate change and rising temperatures. Taiwan is located in the central part of the world's distribution of coral reefs and has about one third of the coral species in the world. This study estimates the welfare losses associated with the potential damage to coral reefs in Taiwan caused by climate change. The contingent valuation method adopted includes a pre-survey, a face-to-face formal survey, and photo illustrations used to obtain reliable data. Average annual personal willingness to pay is found to be around US$35.75 resulting in a total annual willingness to pay of around US$0.43 billion. These high values demonstrate that coral reefs in Taiwan deserve to be well preserved, which would require a dedicated agency and ocean reserves.

  14. The root causes of ineffective and inefficient healthcare technology management in Benin public health sector

    NARCIS (Netherlands)

    Houngbo, T.; Zweekhorst, M.B.M.; Bunders- Aelen, J.G.F.; Coleman, H.L.S.; Medenou, D.; Dakpanon, L.Y.; de Cock Buning, Tjard

    2017-01-01

    This study aims to identify the root causes and solutions of main problems facing Healthcare Technology Management in Benin׳s public health sector. Conducted in Benin from 2008 to 2010, two surveys were used with key actors in Healthcare Technology Management. The first survey was based on 377

  15. Oral Health Problems And Causes Of Tooth Loss At The University ...

    African Journals Online (AJOL)

    Context Several oral diseases and conditions are associated with tooth loss. Objective: The aim of this study was to determine the prevalence of oral health problems seen at the University of Nigeria Teaching Hospital (UNTH) in one year with the view to highlighting causes of tooth loss in this environment. Methods This ...

  16. Ground water pollution by arsenic and its effects on health. Involvement of metabolic methylation in arsenic-induced genetic damage and tumorigenesis; Muki hiso no mechiru ka taisha to idenshi shogaisei narabini shuyo yuhatsusei

    Energy Technology Data Exchange (ETDEWEB)

    Yamanaka, K. [Nihon Univ., Tokyo (Japan)] Okada, S. [Shizuoka Prefecture (Japan)

    1997-07-10

    Drinking water contamination has become a worldwide problem. It is pointed out that re-evaluation of genetic damage with carcinogen is considered as an important problem particularly arsenic`s effects on health. To explain the genetic damage development mechanism of arsenic compound, results of the research conducted on the action of arsenic compound which develops during metabolic methylation process and inorganic arsenic are explained in this paper. The results of the study are summarized as follows. Arsenic genetic damage mutation is caused by dimethyl arsenic in main metabolism than inorganic arsenic. Lung DNA damage is induced by the interaction of O2 and arsenic peroxide radical. Dimethyl arsenic shows very important effect on lung cancer formation process which is induced based on 4-nitroquinoline-1-oxide (4NQO). It not only promotes lung cancer but it also plays an important role in malignant tumor`s mutation. 25 refs., 2 figs.

  17. Algorithms for enhancing public health utility of national causes-of-death data

    Directory of Open Access Journals (Sweden)

    Pourmalek Farshad

    2010-05-01

    Full Text Available Abstract Background Coverage and quality of cause-of-death (CoD data varies across countries and time. Valid, reliable, and comparable assessments of trends in causes of death from even the best systems are limited by three problems: a changes in the International Statistical Classification of Diseases and Related Health Problems (ICD over time; b the use of tabulation lists where substantial detail on causes of death is lost; and c many deaths assigned to causes that cannot or should not be considered underlying causes of death, often called garbage codes (GCs. The Global Burden of Disease Study and the World Health Organization have developed various methods to enhance comparability of CoD data. In this study, we attempt to build on these approaches to enhance the utility of national cause-of-death data for public health analysis. Methods Based on careful consideration of 4,434 country-years of CoD data from 145 countries from 1901 to 2008, encompassing 743 million deaths in ICD versions 1 to 10 as well as country-specific cause lists, we have developed a public health-oriented cause-of-death list. These 56 causes are organized hierarchically and encompass all deaths. Each cause has been mapped from ICD-6 to ICD-10 and, where possible, they have also been mapped to the International List of Causes of Death 1-5. We developed a typology of different classes of GCs. In each ICD revision, GCs have been identified. Target causes to which these GCs should be redistributed have been identified based on certification practice and/or pathophysiology. Proportionate redistribution, statistical models, and expert algorithms have been developed to redistribute GCs to target codes for each age-sex group. Results The fraction of all deaths assigned to GCs varies tremendously across countries and revisions of the ICD. In general, across all country-years of data available, GCs have declined from more than 43% in ICD-7 to 24% in ICD-10. In some regions, such

  18. All-Cause and Acute Pancreatitis Health Care Costs in Patients With Severe Hypertriglyceridemia.

    Science.gov (United States)

    Rashid, Nazia; Sharma, Puza P; Scott, Ronald D; Lin, Kathy J; Toth, Peter P

    2017-01-01

    The aim of this study was to assess health care utilization and costs related to acute pancreatitis (AP) in patients with severe hypertriglyceridemia (sHTG) levels. Patients with sHTG levels 1000 mg/dL or higher were identified from January 1, 2007, to June 30, 2013. The first identified incident triglyceride level was labeled as index date. All-cause, AP-related health care visits, and mean total all-cause costs in patients with and without AP were compared during 12 months postindex. A generalized linear model regression was used to compare costs while controlling for patient characteristics and comorbidities. Five thousand five hundred fifty sHTG patients were identified, and 5.4% of these patients developed AP during postindex. Patients with AP had significantly (P < 0.05) more all-cause outpatient visits, hospitalizations, longer length of stays during the hospital visits, and emergency department visits versus patients without AP. Mean (SD) unadjusted all-cause health care costs in the 12 months postindex were $25,343 ($33,139) for patients with AP compared with $15,195 ($24,040) for patients with no AP. The regression showed annual all-cause costs were 49.9% higher (P < 0.01) for patients with AP versus without AP. Patients who developed AP were associated with higher costs; managing patients with sHTG at risk of developing AP may help reduce unnecessary costs.

  19. Patulin causes DNA damage leading to cell cycle arrest and apoptosis through modulation of Bax, p53 and p21/WAF1 proteins in skin of mice

    International Nuclear Information System (INIS)

    Saxena, Neha; Ansari, Kausar M.; Kumar, Rahul; Dhawan, Alok; Dwivedi, Premendra D.; Das, Mukul

    2009-01-01

    Patulin (PAT), a mycotoxin found in apples, grapes, oranges, pear and peaches, is a potent genotoxic compound. WHO has highlighted the need for the study of cutaneous toxicity of PAT as manual labour is employed during pre and post harvest stages, thereby causing direct exposure to skin. In the present study cutaneous toxicity of PAT was evaluated following topical application to Swiss Albino mice. Dermal exposure of PAT, to mice for 4 h resulted in a dose (40-160 μg/animal) and time (up to 6 h) dependent enhancement of ornithine decarboxylase (ODC), a marker enzyme of cell proliferation. The ODC activity was found to be normal after 12 and 24 h treatment of patulin. Topical application of PAT (160 μg/100 μl acetone) for 24-72 h caused (a) DNA damage in skin cells showing significant increase (34-63%) in olive tail moment, a parameter of Comet assay (b) significant G 1 and S-phase arrest along with induction of apoptosis (2.8-10 folds) as shown by annexin V and PI staining assay through flow cytometer. Moreover PAT leads to over expression of p 21/WAF1 (3.6-3.9 fold), pro apoptotic protein Bax (1.3-2.6) and tumor suppressor wild type p 53 (2.8-3.9 fold) protein. It was also shown that PAT induced apoptosis was mediated through mitochondrial intrinsic pathway as revealed through the release of cytochrome C protein in cytosol leading to enhancement of caspase-3 activity in skin cells of mice. These results suggest that PAT has a potential to induce DNA damage leading to p 53 mediated cell cycle arrest along with intrinsic pathway mediated apoptosis that may also be correlated with enhanced polyamine production as evident by induction of ODC activity, which may have dermal toxicological implications

  20. Visualisation of γH2AX Foci Caused by Heavy Ion Particle Traversal; Distinction between Core Track versus Non-Track Damage

    Science.gov (United States)

    Nakajima, Nakako Izumi; Brunton, Holly; Watanabe, Ritsuko; Shrikhande, Amruta; Hirayama, Ryoichi; Matsufuji, Naruhiro; Fujimori, Akira; Murakami, Takeshi; Okayasu, Ryuichi; Jeggo, Penny; Shibata, Atsushi

    2013-01-01

    Heavy particle irradiation produces complex DNA double strand breaks (DSBs) which can arise from primary ionisation events within the particle trajectory. Additionally, secondary electrons, termed delta-electrons, which have a range of distributions can create low linear energy transfer (LET) damage within but also distant from the track. DNA damage by delta-electrons distant from the track has not previously been carefully characterised. Using imaging with deconvolution, we show that at 8 hours after exposure to Fe (∼200 keV/µm) ions, γH2AX foci forming at DSBs within the particle track are large and encompass multiple smaller and closely localised foci, which we designate as clustered γH2AX foci. These foci are repaired with slow kinetics by DNA non-homologous end-joining (NHEJ) in G1 phase with the magnitude of complexity diminishing with time. These clustered foci (containing 10 or more individual foci) represent a signature of DSBs caused by high LET heavy particle radiation. We also identified simple γH2AX foci distant from the track, which resemble those arising after X-ray exposure, which we attribute to low LET delta-electron induced DSBs. They are rapidly repaired by NHEJ. Clustered γH2AX foci induced by heavy particle radiation cause prolonged checkpoint arrest compared to simple γH2AX foci following X-irradiation. However, mitotic entry was observed when ∼10 clustered foci remain. Thus, cells can progress into mitosis with multiple clusters of DSBs following the traversal of a heavy particle. PMID:23967070

  1. Impact of the Phoretic Phase on Reproduction and Damage Caused by Varroa destructor (Anderson and Trueman to Its Host, the European Honey Bee (Apis mellifera L..

    Directory of Open Access Journals (Sweden)

    Vincent Piou

    Full Text Available Varroa destructor is a parasitic mite of the honeybee that causes thousands of colony losses worldwide. The parasite cycle is composed of a phoretic and a reproductive phase. During the former, mites stay on adult bees, mostly on nurses, to feed on hemolymph. During the latter, the parasites enter brood cells and reproduce. We investigated if the type of bees on which Varroa stays during the phoretic phase and if the duration of this stay influenced the reproductive success of the parasite and the damage caused to bees. For that purpose, we used an in vitro rearing method developed in our laboratory to assess egg laying rate and the presence and number of fully molted daughters. The expression level of two Varroa vitellogenin genes (VdVg1 and VdVg2, known to vary throughout reproduction, was also quantified. Results showed that the status of the bees or time spent during the phoretic phase impacts neither reproduction parameters nor the Varroa vitellogenin genes levels of expression. However, we correlated these parameters to the gene expression and demonstrated that daughters expressed the vitellogenin genes at lower levels than their mother. Regarding the damage to bees, the data indicated that a longer stay on adult bees during the phoretic phase resulted in more frequent physical deformity in newborn bees. We showed that those mites carry more viral loads of the Deformed Wing Virus and hence trigger more frequently overt infections. This study provides new perspectives towards a better understanding of the Varroa-honeybee interactions.

  2. Scanning electron microscopy of damage caused by Mesocyclops thermocyclopoides (Copepoda: Cyclopoidea on larvae of the Dengue fever vector Aedes aegypti (Diptera: Culicidae

    Directory of Open Access Journals (Sweden)

    Stefan Schaper

    2006-09-01

    Full Text Available Dengue fever is a mosquito-borne viral disease, whose main biological vector is Aedes aegypti. This mosquito colonizes tropical areas where the disease is endemic. The most obvious action against dengue is attacking its vector. Biological control appears to be an alternative approach, using natural enemies of the mosquitoes, such as predatory copepods. Thus, the morphological study of the damage caused by copepods is important to understand its predatory capacity. Twenty-five A. aegypti larvae were exposed to the copepod Mesocyclops thermocyclopoides and the damage caused by the copepods was evaluated using scanning electron microscopy. The larvae showed damage mainly at the anal segment, the siphon and the abdomen; only three attacks to the head were observed. The size of the siphon might be of importance in determining whether or not a copepod will attack a mosquito larva. Rev. Biol. Trop. 54 (3: 843-846. Epub 2006 Sept. 29.El dengue es una enfermedad viral transmitida por mosquitos, cuyo principal vector es Aedes aegypti. Este mosquito coloniza muchas áreas tropicales donde la enfermedad es endémica. La acción más obvia contra el dengue es el ataque a su vector. El control biológico parece una buena alternativa, empleando enemigos naturales de los mosquitos, como los copépodos. Por lo tanto, es importante el estudio morfológico del daño causado por los copépodos para comprender su capacidad depredadora. Veinticinco larvas de A. aegypti fueron expuestas a la actividad depredadora del copépodo Mesocyclops thermocyclopoides. Mediante microscopia electrónica de rastreo se evaluó el daño causado por los copépodos. Éstos atacaron principalmente el segmento anal, el sifón y el abdomen de las larvas; sólo vimos tres ataques a la cabeza. El tamaño del sifón podría ser de importancia para predecir si los copépodos pudiesen atacar larvas de determinado mosquito.

  3. Causes and consequences of the sinkhole at El Trébol of Quito, Ecuador - implications for economic damage and risk assessment

    Science.gov (United States)

    Toulkeridis, Theofilos; Rodríguez, Fabián; Arias Jiménez, Nelson; Simón Baile, Débora; Salazar Martínez, Rodolfo; Addison, Aaron; Carreón Freyre, Dora; Mato, Fernando; Díaz Perez, Carmen

    2016-09-01

    The so-called El Trébol is a critical road interchange in Quito connecting the north and south regions of the city. In addition, it connects Quito with the highly populated Los Chillos Valley, one of the most traveled zones in the Ecuadorian capital. El Trébol was constructed in the late 1960s in order to resolve the traffic jams of the capital city and for that purpose the Machángara River was rerouted through an underground concrete box tunnel. In March 2008, the tunnel contained a high amount of discarded furniture that had been impacting the top portion of the tunnel, compromising the structural integrity. On 31 March 2008 after a heavy rainfall a sinkhole of great proportions formed in the Trébol traffic hub. In the first few minutes, the sinkhole reached an initial diameter of 30 m. The collapse continued to grow in the following days until the final dimensions of 120 m in diameter and some 40 m of depth, revealing the Machángara River at the base of the sinkhole.A state of emergency was declared. The cause of the sinkhole was a result of the lack of monitoring of the older subterranean infrastructure where trash had accumulated and damaged the concrete tunnel that channelized the Machángara River until it was worn away for a length of some 20 m, leaving behind the sinkhole and the fear of recurrence in populated areas.With the intent to understand the causes and consequences of this sinkhole event, rainfall data are shown together with hydrogeological characteristics and a view back to the recent history of sinkhole lineation or arrangement of the city of Quito. The economic impact is also emphasized, where the direct costs of the damage and the reconstruction are presented and compared to indirect costs associated with this socio-natural disaster. These analyses suggest that the costs of indirect financial damage, like time loss or delay, and subsequent higher expenses for different types of vehicles, are equivalent to many times the costs of the

  4. Health Risk Assessment and DNA Damage of Volatile Organic Compounds in Car Painting Houses

    Directory of Open Access Journals (Sweden)

    Patpida Siripongpokin

    2014-06-01

    Full Text Available Car painters who work near volatile organic compounds (VOCs sources, including paints, solvents and painting processes may be exposed to highly elevated VOCs levels. This study investigates air samples from car painting houses in Thailand to evaluate the health risks following inhalation exposure. Personal air samplings were obtained at nine garages in Phitsanulok, Thailand from June to September 2012. The concentrations of benzene, toluene, ethylbenzene, xylenes, and styrene in the air workplaces were significantly higher than in a control group of office workers (p < 0.05. Toluene, xylene and ethylbenzene were the most abundant species. However, all VOCs in these air samples were lower than TWA limit of Thailand and the OSHA standard. The lifetime cancer and non-cancer risks for the workers exposed to VOCs were also assessed. The average lifetime cancer risk was 41.0 (38.2-47.2 per million, which is in the acceptable risk. The average lifetime non-cancer risk, the HI, was 0.962 (0.643-1.397, which is well below the reference hazard level. Urine samples, collected after 8-h work periods which were analyzed for VOCs metabolites, including t,t muconic acid, hippuric acid, mandelic acid and m-hippuric acid, demonstrate that the average levels of metabolites in car painters and in controls were close. All VOCs metabolites in urine samples were lower than BEI of ACGIH standard. Blood samples, collected after 8-h work periods which were analyzed by single cell gel electrophoresis (comet assay. The DNA damage, assessed by tail moment, demonstrates that the average of tail moment in car painters were significantly higher than in the controls (p < 0.05.

  5. A study of two unsupervised data driven statistical methodologies for detecting and classifying damages in structural health monitoring

    Science.gov (United States)

    Tibaduiza, D.-A.; Torres-Arredondo, M.-A.; Mujica, L. E.; Rodellar, J.; Fritzen, C.-P.

    2013-12-01

    This article is concerned with the practical use of Multiway Principal Component Analysis (MPCA), Discrete Wavelet Transform (DWT), Squared Prediction Error (SPE) measures and Self-Organizing Maps (SOM) to detect and classify damages in mechanical structures. The formalism is based on a distributed piezoelectric active sensor network for the excitation and detection of structural dynamic responses. Statistical models are built using PCA when the structure is known to be healthy either directly from the dynamic responses or from wavelet coefficients at different scales representing Time-frequency information. Different damages on the tested structures are simulated by adding masses at different positions. The data from the structure in different states (damaged or not) are then projected into the different principal component models by each actuator in order to obtain the input feature vectors for a SOM from the scores and the SPE measures. An aircraft fuselage from an Airbus A320 and a multi-layered carbon fiber reinforced plastic (CFRP) plate are used as examples to test the approaches. Results are presented, compared and discussed in order to determine their potential in structural health monitoring. These results showed that all the simulated damages were detectable and the selected features proved capable of separating all damage conditions from the undamaged state for both approaches.

  6. The resources that matter: fundamental social causes of health disparities and the challenge of intelligence.

    Science.gov (United States)

    Link, Bruce G; Phelan, Jo C; Miech, Richard; Westin, Emily Leckman

    2008-03-01

    A robust and very persistent association between indicators of socioeconomic status (SES) and the onset of life-threatening disease is a prominent concern of medical sociology. The persistence of the association over time and its generality across very different places suggests that no fixed set of intervening risk and protective factors can account for the connection. Instead, fundamental-cause theory views SES-related resources of knowledge, money, power prestige, and beneficial social connections as flexible resources that allow people to avoid risks and adopt protective strategies no matter what the risk and protective factors are in a given place or time. Recently, however, intelligence has been proposed as an alternative flexible resource that could fully account for the association between SES and health and thereby find its place as the epidemiologists' "elusive fundamental cause" (Gottfredson 2004). We examine the direct effects of intelligence test scores and adult SES in two data sets containing measures of intelligence, SES, and health. In analyses of prospective data from both the Wisconsin Longitudinal Study and the Health and Retirement Survey, we find little evidence of a direct effect of intelligence on health once adult education and income are held constant. In contrast, the significant effects of education and income on health change very little when intelligence is controlled. Although data limitations do not allow a definitive resolution of the issue, this evidence is inconsistent with the claim that intelligence is the elusive fundamental cause of health disparities, and instead supports the idea that the flexible resources people actively use to gain a health advantage are the SES-related resources of knowledge, money, power, prestige, and beneficial social connections.

  7. Damage mapping in structural health monitoring using a multi-grid architecture

    Energy Technology Data Exchange (ETDEWEB)

    Mathews, V. John [Dept. of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT 84112 (United States)

    2015-03-31

    This paper presents a multi-grid architecture for tomography-based damage mapping of composite aerospace structures. The system employs an array of piezo-electric transducers bonded on the structure. Each transducer may be used as an actuator as well as a sensor. The structure is excited sequentially using the actuators and the guided waves arriving at the sensors in response to the excitations are recorded for further analysis. The sensor signals are compared to their baseline counterparts and a damage index is computed for each actuator-sensor pair. These damage indices are then used as inputs to the tomographic reconstruction system. Preliminary damage maps are reconstructed on multiple coordinate grids defined on the structure. These grids are shifted versions of each other where the shift is a fraction of the spatial sampling interval associated with each grid. These preliminary damage maps are then combined to provide a reconstruction that is more robust to measurement noise in the sensor signals and the ill-conditioned problem formulation for single-grid algorithms. Experimental results on a composite structure with complexity that is representative of aerospace structures included in the paper demonstrate that for sufficiently high sensor densities, the algorithm of this paper is capable of providing damage detection and characterization with accuracy comparable to traditional C-scan and A-scan-based ultrasound non-destructive inspection systems quickly and without human supervision.

  8. Structural health monitoring using DOG multi-scale space: an approach for analyzing damage characteristics

    Science.gov (United States)

    Guo, Tian; Xu, Zili

    2018-03-01

    Measurement noise is inevitable in practice; thus, it is difficult to identify defects, cracks or damage in a structure while suppressing noise simultaneously. In this work, a novel method is introduced to detect multiple damage in noisy environments. Based on multi-scale space analysis for discrete signals, a method for extracting damage characteristics from the measured displacement mode shape is illustrated. Moreover, the proposed method incorporates a data fusion algorithm to further eliminate measurement noise-based interference. The effectiveness of the method is verified by numerical and experimental methods applied to different structural types. The results demonstrate that there are two advantages to the proposed method. First, damage features are extracted by the difference of the multi-scale representation; this step is taken such that the interference of noise amplification can be avoided. Second, a data fusion technique applied to the proposed method provides a global decision, which retains the damage features while maximally eliminating the uncertainty. Monte Carlo simulations are utilized to validate that the proposed method has a higher accuracy in damage detection.

  9. Genome health nutrigenomics and nutrigenetics--diagnosis and nutritional treatment of genome damage on an individual basis.

    Science.gov (United States)

    Fenech, Michael

    2008-04-01

    The term nutrigenomics refers to the effect of diet on gene expression. The term nutrigenetics refers to the impact of inherited traits on the response to a specific dietary pattern, functional food or supplement on a specific health outcome. The specific fields of genome health nutrigenomics and genome health nutrigenetics are emerging as important new research areas because it is becoming increasingly evident that (a) risk for developmental and degenerative disease increases with DNA damage which in turn is dependent on nutritional status and (b) optimal concentration of micronutrients for prevention of genome damage is also dependent on genetic polymorphisms that alter function of genes involved directly or indirectly in uptake and metabolism of micronutrients required for DNA repair and DNA replication. Development of dietary patterns, functional foods and supplements that are designed to improve genome health maintenance in humans with specific genetic backgrounds may provide an important contribution to a new optimum health strategy based on the diagnosis and individualised nutritional treatment of genome instability i.e. Genome Health Clinics.

  10. Preventive Effect of the Korean Traditional Health Drink (Taemyeongcheong) on Acetaminophen-Induced Hepatic Damage in ICR Mice

    OpenAIRE

    Yi, Ruo-Kun; Song, Jia-Le; Lim, Yaung-Iee; Kim, Yong-Kyu; Park, Kun-Young

    2015-01-01

    This study was to investigate the preventive effect of taemyeongcheong (TMC, a Korean traditional health drink) on acetaminophen (APAP, 800 mg/kg BW)-induced hepatic damage in ICR mice. TMC is prepared from Saururus chinensis, Taraxacum officinale, Zingiber officinale, Cirsium setidens, Salicornia herbacea, and Glycyrrhizae. A high dose of TMC (500 mg/kg BW) was found to decrease APAP-induced increases in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphata...

  11. Effect of mucoprotective plant-derived therapies on damage to colonic mucosa caused by carprofen and robenacoxib administered to healthy dogs for 21 days.

    Science.gov (United States)

    Szweda, Magdalena; Szarek, Józef; Dublan, Krystyna; Męcik-Kronenberg, Tomasz; Kiełbowicz, Zdzisław; Bigoszewski, Marcin

    2014-01-01

    Non-steroidal anti-inflammatory drugs (NSAIDs) may cause gastrointestinal damage in dogs. To determine the extent to which lansoprazole, liquorice extract, and a herbal solution exhibit protective effects on colonic mucosa when administered to dogs concurrently with the NSAIDs carprofen or robenacoxib. Thirty-five healthy beagle dogs (15 male and 20 female) aged 13-14 weeks and weighing 4.3-5.5 kg at the beginning of the experiment were included. Endoscopy and biopsy of the caudal gastrointestinal tract were performed pretreatment and on the last day of a 21-day treatment period with (1) oral carprofen; (2) carprofen and the proton-pump inhibitor lansoprazole; (3) carprofen, liquorice extract, and a herbal solution that contained extracts of thyme, icelandic lichen, hyssop, and saponariae root; (4) robenacoxib; (5) robenacoxib and lansoprazole; (6) robenacoxib, liquorice extract, and herbal solution; or (7) an empty gelatin capsule. Statistical analyses were performed with the Kruskal-Wallis, Cochran's Q, and chi-squared test with p carprofen and robenacoxib tested damaged the colonic mucosa with most severe microscopic lesions following administration of robenacoxib with lansoprazole. The risk of histopathological lesions in the colon increased most rapidly in robenacoxib with lansoprazole (absolute risk increase -0.85) similar to robenacoxib only (-0.75), whereas the best result was recorded following the plant remedies together with carprofen (-0.15) and the plant remedies together with robenacoxib (-0.2). Concurrent administration of liquorice extract and an herbal solution with robenacoxib was associated with decreased severity of the NSAID-induced mucosal lesions.

  12. Hepatitis B virus induces IL-23 production in antigen presenting cells and causes liver damage via the IL-23/IL-17 axis.

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    Qinghong Wang

    Full Text Available IL-23 regulates myriad processes in the innate and adaptive immune systems, and is a critical mediator of the proinflammatory effects exerted by Th17 cells in many diseases. In this study, we investigated whether and how hepatitis B virus (HBV causes liver damage directly through the IL-23 signaling pathway. In biopsied liver tissues from HBV-infected patients, expression of both IL-23 and IL-23R was remarkably elevated. In vivo observations also indicated that the main sources of IL-23 were myeloid dendritic cells (mDCs and macrophages. Analysis of in vitro differentiated immature DCs and macrophages isolated from healthy donors revealed that the HBV surface antigen (HBsAg efficiently induces IL-23 secretion in a mannose receptor (MR-dependent manner. Culture with an endosomal acidification inhibitor and the dynamin inhibitor showed that, upon binding to the MR, the HBsAg is taken up by mDCs and macrophages through an endocytosis mechanism. In contrast, although the HBV core antigen (HBcAg can also stimulate IL-23 secretion from mDCs, the process was MR- and endocytosis-independent. In addition, IL-23 was shown to be indispensible for HBsAg-stimulated differentiation of naïve CD4(+ T cells into Th17 cells, which were determined to be the primary source of IL-17 in HBV-infected livers. The cognate receptor, IL-17R, was found to exist on the hepatic stellate cells and mDCs, both of which might represent the potential target cells of IL-17 in hepatitis B disease. These data provide novel insights into a yet unrecognized mechanism of HBV-induced hepatitis, by which increases in IL-23 expression, through an MR/endocytosis-dependent or -independent manner, produce liver damage through the IL-23/IL-17 axis.

  13. [Three-month rehabilitation of a patient with the III, IV and VI cranial nerve damage caused by a neurosurgery of the left internal carotid artery aneurysm].

    Science.gov (United States)

    Mosiński, Eliasz; Kikowski, Łukasz; Irzmański, Robert

    Introduction: Oculomotor nerve palsy is an eye condition resulting from damage to the third cranial nerve or a branch thereof. Third nerve damage weakens the muscles innervated by the nerve . Also adversely affect the fourth and sixth nerve , causing impairment of their activity. Rehabilitation third nerve palsy is rarely described in the available literature . The whole process is very difficult , but the effects of physiotherapy is very beneficial for the patient. The aim:The assessment of the influence of the outpatient rehabilitation on the patient's condition after a three-month treatment and the use of physical therapy. Material and methods:Case studies of the 38-yerar-old patient after having operated a big aneurism of the left ICA, which was clipped. After the procedure, the III, IV and VI cranial nerves were deeply impaired and the amnesic aphasia occurred. The patient started the rehabilitation a month after the incident. To assess the process of rehabilitation, the own movement examination of the eyeball was implemented. Active and passive exercises, Tigger Point therapy, kinesiotaping, laser and electrostimulation were inserted. Results: The significant improvement of the eyeball movement has been proved on the basis of the same own examination. A physiotherapy has had a positive influence on the speech disorder, namely amnesic aphasia, and after the month of the rehabilitation it has been completely removed. The positive influence of the rehabilitation, which has been pointed out, is clinically essential. Conclusions: Obtained results have not been described in literature yet, that is why it is essential to widen further research and emphasise the importance of the rehabilitation, which is rarely implemented in an intense way in such medical conditions.

  14. Improving the Health of Cambodian Americans: Grassroots Approaches and Root Causes.

    Science.gov (United States)

    Lee, Juliet P; Kirkpatrick, Sean; Rojas-Cheatham, Ann; Sin, Talaya; Moore, Roland S; Tan, Sotheavy; Godoy, Shadia; Ercia, Angelo

    2016-01-01

    Cambodian Americans experience great disparities in health compared to other Americans, yet may be underserved by conventional healthcare systems. Community-based participatory research (CBPR) is a means to engage underserved communities in health research and programming. We describe results of our efforts to engage the Cambodian grassroots members as well as formal leaders in Oakland, California. In addition to a community advisory group, we convened a Community Work Group (CWG), composed of 10 grassroots community women of varying ages and backgrounds. The project aimed to leverage the lived experiences of these women and their understandings of health and wellness in identifying specific health issues and developing culturally resonant strategies. The CWG met weekly with staff facilitators using methods for collective analysis including theater, body mapping, and other expressive arts. The approach proved logistically challenging, but resulted in novel analyses and strategies. The group identified trauma, along with poor access to education, unemployment and underemployment, social isolation, and generation gap, together with community violence, as root causes of key behavioral health issues, namely, alcohol abuse, gambling, prescription drug misuse, and domestic violence. Strategies proposed and implemented by the group and project staff were a community garden, Cambodian New Year's celebrations, and a museum exhibit on the Cambodian refugee experiences. Grassroots community engagement can support projects in identifying social determinants of health and developing the capacities of community members to conduct research and actions to improve health.

  15. Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems

    Directory of Open Access Journals (Sweden)

    Suliman Khan

    2018-01-01

    Full Text Available Shiftwork became common during the last few decades with the growing demands of human life. Despite the social inactivity and irregularity in habits, working in continuous irregular shifts causes serious health issues including sleep disorders, psychiatric disorders, cancer, and metabolic disorders. These health problems arise due to the disruption in circadian clock system, which is associated with alterations in genetic expressions. Alteration in clock controlling genes further affects genes linked with disorders including major depression disorder, bipolar disorder, phase delay and phase advance sleep syndromes, breast cancer, and colon cancer. A diverse research work is needed focusing on broad spectrum changes caused by jet lag in brain and neuronal system. This review is an attempt to motivate the researchers to conduct advanced studies in this area to identify the risk factors and mechanisms. Its goal is extended to make the shift workers aware about the risks associated with shiftwork.

  16. Important knowledge gaps among pastoralists on causes and treatment of udder health problems in livestock in southern Ethiopia: results of qualitative investigation.

    Science.gov (United States)

    Amenu, Kebede; Szonyi, Barbara; Grace, Delia; Wieland, Barbara

    2017-10-23

    Ethiopia has high prevalences of udder health problems including clinical and subclinical mastitis across production systems in different livestock species. Previous studies on udder health problems have largely focused on identification of mastitis causing microbial pathogens and associated risk factors. However, relatively little is known about the knowledge and beliefs of livestock keepers regarding udder health problems. An understanding of the beliefs on the other hand would facilitate effective communication between livestock keepers and animal health professionals. Therefore, this study aimed at exploring the knowledge and belief surrounding the causes, clinical signs and treatments for udder health problems in (agro-) pastoral communities in southern Ethiopia using qualitative investigation. The result showed that udder health problem, locally known as 'dhukkuba muchaa', which translates to 'disease of teats', was classified into three main types: (1) tick infestation (dirandisa), (2) swelling of udder often with pus discharge (nyaqarsa) and (3) acute mastitis caused by evil eye (buda) with 'bloody milk'. Tick infestation was perceived to directly cause mechanical damage to udder tissue or to resulting in swelling leading to nyaqarsa. Our analysis also revealed the strong misperception that acute and severe swelling of udder was caused by evil eye. According to the pastoralists, cows with large udders in the late pregnancy are prone to evil eye infliction upon giving birth. The pastoralists often treat udder health problems by combining both modern and traditional methods. Removal of ticks by hand and acarcide application were the preferred methods for limiting tick infestation while swelling and evil eye cases were treated with antibiotics (e.g. oxytetracycline). The study also revealed that specific herbs, only known by the herbalists, were used for traditional treatment of udder health. Although this information could not be divulged at the time, it

  17. Root-Zone Redox Dynamics - In Search for the Cause of Damage to Treated-Wastewater Irrigated Orchards in Clay Soils

    Science.gov (United States)

    Yalin, David; Shenker, Moshe; Schwartz, Amnon; Assouline, Shmuel; Tarchitzky, Jorge

    2016-04-01

    Treated wastewater (TW) has become a common source of water for agriculture. However recent findings raise concern regarding its use: a marked decrease (up to 40%) in yield appeared in orchards irrigated with TW compared with fresh water (FW) irrigated orchards. These detrimental effects appeared predominantly in orchards cultivated in clay soils. The association of the damage with clay soils rather than sandy soils led us to hypothesize that the damage is linked to soil aeration problems. We suspected that in clay soils, high sodium adsorption ratio (SAR) and high levels of organic material, both typical of TW, may jointly lead to an extreme decrease in soil oxygen levels, so as to shift soil reduction-oxidation (redox) state down to levels that are known to damage plants. Two-year continuous measurement of redox potential, pH, water tension, and oxygen were conducted in the root-zone (20-35 cm depth) of avocado trees planted in clay soil and irrigated with either TW or FW. Soil solution composition was sampled periodically in-situ and mineral composition was sampled in tree leaves and woody organs biannually. In dry periods the pe+pH values indicated oxic conditions (pe+pH>14), and the fluctuations in redox values were small in both TW and FW plots. Decreases in soil water tension following irrigation or rain were followed by drops in soil oxygen and pe+pH values. TW irrigated plots had significantly lower minimum pe+pH values compared with FW-irrigated plots, the most significant differences occurred during the irrigation season rather than the rain season. A linear correlation appeared between irrigation volume and reduction severity in TW-irrigated plots, but not in the FW plots, indicating a direct link to the irrigation regime in TW-irrigated plots. The minimum pe+pH values measured in the TW plots are indicative of suboxic conditions (9water tension and oxygen concentration levels. The consequences of our findings to plant health will be discussed, and

  18. [Health as utopia. Grounds and causes of lack of demand for early diagnostic measures (author's transl)].

    Science.gov (United States)

    Buser, K; Oeter, K

    1981-11-27

    The quite obvious neglect of prophylactic measures cannot be attributed to a single cause only. Ground are rather to be found both in the psychic disposition and in the social stratum of the population as well as in the nature of the prophylaxis available. A synopsis leads to the conclusion that effective prevention requires not only changing the attitude of the patient or the population but also that of the supplier of the health promoting services.

  19. A novel nonlinear damage resonance intermodulation effect for structural health monitoring

    Science.gov (United States)

    Ciampa, Francesco; Scarselli, Gennaro; Meo, Michele

    2017-04-01

    This paper is aimed at developing a theoretical model able to predict the generation of nonlinear elastic effects associated to the interaction of ultrasonic waves with the steady-state nonlinear response of local defect resonance (LDR). The LDR effect is used in nonlinear elastic wave spectroscopy to enhance the excitation of the material damage at its local resonance, thus to dramatically increase the vibrational amplitude of material nonlinear phenomena. The main result of this work is to prove both analytically and experimentally the generation of novel nonlinear elastic wave effects, here named as nonlinear damage resonance intermodulation, which correspond to a nonlinear intermodulation between the driving frequency and the LDR one. Beside this intermodulation effect, other nonlinear elastic wave phenomena such as higher harmonics of the input frequency and superharmonics of LDR frequency were found. The analytical model relies on solving the nonlinear equation of motion governing bending displacement under the assumption of both quadratic and cubic nonlinear defect approximation. Experimental tests on a damaged composite laminate confirmed and validated these predictions and showed that using continuous periodic excitation, the nonlinear structural phenomena associated to LDR could also be featured at locations different from the damage resonance. These findings will provide new opportunities for material damage detection using nonlinear ultrasounds.

  20. Causes for the underreporting of adverse drug events by health professionals: a systematic review

    Directory of Open Access Journals (Sweden)

    Fabiana Rossi Varallo

    2014-08-01

    Full Text Available Objective: Identifying the main causes for underreporting of Adverse Drug Reaction (ADR by health professionals. Method: A systematic review carried out in the following databases: LILACS, PAHO, SciELO, EMBASE and PubMed in the period between 1992 and 2012. Descriptors were used in the search for articles, and the identified causes of underreporting were analyzed according to the classification of Inman. Results: In total, were identified 149 articles, among which 29 were selected. Most studies were carried out in hospitals (24/29 for physicians (22/29, and pharmacists (10/29. The main causes related to underreporting were ignorance (24/29, insecurity (24/29 and indifference (23/29. Conclusion: The data show the eighth sin in underreporting, which is the lack of training in pharmacovigilance. Therefore, continuing education can increase adherence of professionals to the service and improve knowledge and communication of risks due to drug use.

  1. [Effect of oxidative stress-associated damage to the lung tissue caused by different body mass index in the rat models].

    Science.gov (United States)

    Li, X Y; Zhang, X J; Zhao, J H; Xu, J Y

    2016-12-12

    Objective: To investigate the influence of different diets on serum protein expression levels of 4-hydroxynonenal (4-HNE), thioredoxin (Trx), thioredoxin reductase (TrxR) and the activities of Trx and TrxR, and to explore the effect of damage to the lung tissue and the underlying mechanisms of different body mass index caused by different diets in the rat models . Method: Healthy clean male SD rats were randomly divided into normal group, emaciation group and fat group, which were raised by different diets for 6 months.Then the rats were sacrificed and the serum and lung tissue were prepared. The levels of 4-HNE, Trx and TrxR in peripheral blood were quantitatively analyzed by enzyme-linked immunosorbent assay(ELISA), and the activities of Trx and TrxR were measured by chemical methods. Results: Compared with the normal group, the lung tissue had more apparent emphysema in the emaciation and the fat groups under light microscope, and more inflammatory cell infiltration in alveolar septum was observed in the fat group.The levels of 4-HNE in the fat group[(24.7±8.7)mg/L]was significantly higher than that in the normal group[(15.4±4.7)mg/L, P 0.05)in the levels of 4-HNE between the emaciation and the normal groups. The levels of TrxR in the emaciation group[(7.7±1.4)μg/ml]was significantly higher than that in the normal and the fat groups[(6.2±1.1), (4.9±1.4)μg/ml, all P 0.05). The activity of Trx in the emaciation group[(32.4±8.5)×10 -3 A ·min -1 ·mg -1 ]was significantly higher than that in the normal group[(19.6±3.3)×10 -3 A ·min -1 ·mg -1 ]and the fat group[(11.3±7.5)×10 -3 A ·min -1 ·mg -1 , all P 0.05). Conclusion: Both high BMI and low BMI can affect the oxidative stress of the body, resulting in increased oxidants and decreased antioxidants, and can cause damage to the lung tissue in the rat models.

  2. Changes in bacterial flora associated with skin damage on hands of health care personnel.

    Science.gov (United States)

    Larson, E L; Hughes, C A; Pyrek, J D; Sparks, S M; Cagatay, E U; Bartkus, J M

    1998-10-01

    In a prospective observational study of 40 nurses (20 with diagnosed hand irritation and 20 without), nurses with damaged hands did not have higher microbial counts (P = .63), but did have a greater number of colonizing species (means: 3.35 and 2.63, P = .03). Although numbers were small, nurses with damaged hands were significantly more likely to be colonized with Staphylococcus hominis (P = .03). Fifty-nine percent of S hominis isolates from nurses with damaged hands were resistant to methicillin compared with 27% of isolates from those with healthy skin (P = .14). Twenty percent of nurses with damaged hands were colonized with Staphylococcus aureus compared with none of the nurses with normal hands (P = .11). Nurses with damaged hands were also twice as likely to have gram-negative bacteria (P = .20), entercocci (P = .13), and Candida (P = .30) present on the hands. Antimicrobial resistance of the coagulase-negative staphylococcal flora (with the exception of S hominis) did not differ between the 2 groups, nor did a trend toward increasing resistance exist when compared with other studies during the past decade. Skin moisturizers and protectant products were used almost universally by nurses at work, primarily products brought from home. Efforts to improve hand condition are warranted because skin damage can change microbial flora. Such efforts should include assessment or monitoring of hand care practices, formal institutional policy adoption and control of use of skin protectant products or lotions, and prudent use of latex gloves or more widespread use of powder-free and nonlatex products.

  3. The "brain drain" of health care workers: causes, solutions and the example of Jamaica.

    Science.gov (United States)

    Lofters, Aisha K

    2012-07-18

    Despite much media attention being given to the physician shortage in Canada in recent years, this shortage pales in comparison to that seen in many middle- and low-income countries. A major cause of the shortage in these countries is the migration of health care workers from developing to developed nations, a phenomenon known as the "brain drain". The loss of these workers is having devastating impacts globally, particularly in Sub-Saharan Africa and the Caribbean. Causes of the "brain drain" are numerous and include poor working conditions in poorer countries and active recruitment by richer countries. Jamaica has been one of the countries in the Caribbean hardest hit by mass migration of health care workers. The multiple dimensions of Jamaica's health worker "brain drain" illustrate both the complexity of the issues reviewed in this commentary, and the net loss for low- and middle-income countries. Creative and sustainable solutions to the problem are actively being sought globally, but will require commitment and support from all nations as well as from international funding bodies if meaningful impacts on health are to be realized.

  4. Smoking Prevalence Among Mugla School of Health Sciences Students and Causes of Leading Increase in Smoking

    Directory of Open Access Journals (Sweden)

    Metin Picakciefe

    2007-08-01

    Full Text Available The purpose of this study was to determine the smoking prevalence among Mugla School of Health Sciences students, to determine the effects the increasing causes of smoking and their education about adverse health outcome of smoking. A cross-sectional study was performed among Mugla School of Health Sciences students in Mugla University. All students (417 in Mugla School of Health Sciences included in the study. The participation rates was 85.1%. Data were obtained by the self-administered questionnaire without teachers in classes. SPSS 11.0 was used for data analysis, and the differentiation was assessed by Chi-square analysis. P < 0.05 was accepted statistically significant. The prevalence of current smokers was 25.3% among students in Mugla School of Health Sciences. The students stated that the most important factor of smoking initiation was stress (59.2%. The univariable analysis showed that the friends’ smoking (p: 0.000 , having knowledge about smoking habits of teachers (p: 0.020 , alcohol consumption (p: 0.000, and other smokers out of parent in the home (p: 0.000 was significantly associated with increasing rate of smoking prevalence. The smoking prevalence was quite high (25.3% among Mugla School of Health Sciences students in Mugla University. It is needed to decreasing smoking prevalence among students that antismoking education should be reevaluated, that antismoking campaign should be administered in schools. [TAF Prev Med Bull 2007; 6(4.000: 267-272

  5. Health professionals' migration in emerging market economies: patterns, causes and possible solutions.

    Science.gov (United States)

    Nair, Manisha; Webster, Premila

    2013-03-01

    About a third of the countries affected by shortage of human resources for health are the emerging market economies (EMEs). The greatest shortage in absolute terms was found to be in India and Indonesia leading to health system crisis. This review identifies the patterns of migration of health workers, causes and possible solutions in these EMEs. A qualitative synthesis approach based on the 'critical review' and 'realist review' approaches to the literature review was used. The patterns of migration of health professionals' in the EMEs have led to two types of discrepancies between health needs and healthcare workers: (i) within country (rural-urban, public-private or government healthcare sector-private sector) and (ii) across countries (south to north). Factors that influence migration include lack of employment opportunities, appropriate work environment and wages in EMEs, growing demand in high-income countries due to demographic transition, favourable country policies for financial remittances by migrant workers and medical education system of EMEs. A range of successful national and international initiatives to address health workforce migration were identified. Measures to control migration should be country specific and designed in accordance with the push and pull factors existing in the EMEs.

  6. Exploring occupational and health behavioral causes of firefighter obesity: a qualitative study.

    Science.gov (United States)

    Dobson, Marnie; Choi, BongKyoo; Schnall, Peter L; Wigger, Erin; Garcia-Rivas, Javier; Israel, Leslie; Baker, Dean B

    2013-07-01

    Firefighters, as an occupational group, have one of the highest prevalence rates of obesity. A qualitative study investigated occupational and health behavioral determinants of obesity among firefighters. Four focus groups were conducted with firefighters of every rank as Phase I of the FORWARD study which was designed to assess health behavioral and occupational characteristics related to obesity in firefighters. Analysis revealed five main themes of central importance to firefighters: (1) fire station eating culture; (2) night calls and sleep interruption; (3) supervisor leadership and physical fitness; (4) sedentary work; and (5) age and generational influences. The results showed a strong interrelationship between occupational and health behavioral causes of obesity in firefighters. The relevance of these qualitative findings are discussed along with the implications for future obesity interventions with firefighters. Copyright © 2013 Wiley Periodicals, Inc.

  7. Structural health monitoring and damage assessment using measured FRFs from multiple sensors. Part II. Decision making with RBF networks

    Energy Technology Data Exchange (ETDEWEB)

    Zang, C.; Friswell, M.I. [Dept. of Aerospace Engineering, Univ. of Bristol, Bristol (United Kingdom); Imregun, M. [Dept. of Mechanical Engineering, Imperial Coll., London (United Kingdom)

    2003-07-01

    This paper is the second of two papers concerned with structural health monitoring and damage assessment using measured FRFs from multiple sensors, and discusses the decision making technique with radial basis function (RBF) neural networks. In PART 1 of the paper, the correlation criteria showed their capability to indicate various changes to the structure's state. PART 2, presented here, develops the methodology of decision theory to identify precisely all of the structure states. Although, the statistical approach can be used for classification, interpreting the information is difficult. Neural network techniques have been proven to possess many advantages for classification due to their learning ability and good generalization. In this paper, the radial basis function neural network is applied for function approximation and recognition. The key idea is to partition the input space (the indicators of the correlation criteria) into a number of subspaces that are in the form of hyper spheres. Then, the widely used k-mean clustering algorithm was selected as a logical approach to detecting the structure states. A bookshelf structure with measured frequency responses from 24 accelerometers was used to demonstrate the effectiveness of the method. The results show the successful classification of all structure states, for instance, the undamaged and damage states, damage locations and damage levels, and the environmental variability. (orig.)

  8. Downsizing of a provincial department of health--causes and implications for fiscal policy.

    Science.gov (United States)

    Blecher, Mark

    2002-06-01

    To analyse the financial basis for downsizing of a provincial health department and suggest implications for fiscal policy. Analysis of relevant departmental, provincial and national financing and expenditure trends from 1995/96 to 2002/03. Western Cape (WC) Department of Health (DOH). Downsizing involving 9,282 health workers (27.9%) and closure of 3,601 hospital beds (24.4%) over 5 years. Total aggregate provincial transfers (all provinces) remained fairly constant in real terms. The WC's share decreased from 11.8% in 1996/97 to 9.8% in 2002/03. This was offset by the DOH's share of the WC budget increasing from 25.6% to 29.6%, mainly because of an increase in national health conditional grants. The net effect of financing changes was that the DOH's allocation in real terms was similar in 2002/03 and 1995/96, which suggests that financing changes are not the major cause of downsizing. Expenditure analysis revealed a 39.7% real rise in the average cost of health personnel. Substantial interprovincial inequities remain. The major cause of downsizing was wage growth, particularly following the 1996 wage agreement. Disjointed fiscal and wage policy has affected health services. Simultaneous application of policies of fiscal constraint, redistribution and substantial real wage growth has resulted in substantial downsizing with limited inroads into inequities. Inequities will continue to call for further redistribution, reduction in conditional grants and downsizing, much of which could have been avoided if fiscal and wage policy choices had been optimal.

  9. CT patterns of pleuro-pulmonary damage caused by inhalation of pumice as a model of pneumoconiosis from non-fibrous amorphous silicates.

    Science.gov (United States)

    Costa, Chiara; Ascenti, Giorgio; Scribano, Emanuele; D'Angelo, Tommaso; Gaeta, Michele; Fenga, Concettina; Blandino, Alfredo; Mazziotti, Silvio

    2016-01-01

    The aim of this article is to correlate the radiological features of pleuro-pulmonary damage caused by inhalation of pumice (an extrusive volcanic rock classified as a non-fibrous, amorphous, complex silicate) with exposure conditions. 36 subjects employed in the pumice quarries were evaluated for annual follow-up in a preventive medical surveillance program including spirometry, chest CT lasting from 1999 to 2014. They were only male subjects, mean age 56.92 ± 16.45 years. Subjects had worked in the quarries for an average of 25.03 ± 9.39 years. Domestic or occupational exposure to asbestos or other mineral dusts other than pumice was excluded. Subjects were also classified as smokers, former smokers and nonsmokers. Among the 36 workers examined, we identified four CT patterns which resulted to be dependent on exposure duration and intensity, FVC, FEV1 and FEF25-75, but not on cigarette smoking. The most common symptoms reported by clinical examination were dyspnoea, cough and asthenia. In no case it was proven an evolution of CT findings during follow-up for 10 years. Liparitosis, caused by pumice inhalation, can be considered a representative example of pneumoconiosis derived by amorphous silica compounds, which are extremely widespread for industrial manufacturing as well as for applicative uses, such as nano-materials. Moreover, being pumice free of quartz contamination, it can represent a disease model for exposure to pure non-fibrous silicates.

  10. Inhibition of ErbB2 by receptor tyrosine kinase inhibitors causes myofibrillar structural damage without cell death in adult rat cardiomyocytes

    International Nuclear Information System (INIS)

    Pentassuglia, Laura; Graf, Michael; Lane, Heidi; Kuramochi, Yukio; Cote, Gregory; Timolati, Francesco; Sawyer, Douglas B.; Zuppinger, Christian; Suter, Thomas M.

    2009-01-01

    Inhibition of ErbB2 (HER2) with monoclonal antibodies, an effective therapy in some forms of breast cancer, is associated with cardiotoxicity, the pathophysiology of which is poorly understood. Recent data suggest, that dual inhibition of ErbB1 (EGFR) and ErbB2 signaling is more efficient in cancer therapy, however, cardiac safety of this therapeutic approach is unknown. We therefore tested an ErbB1-(CGP059326) and an ErbB1/ErbB2-(PKI166) tyrosine kinase inhibitor in an in-vitro system of adult rat ventricular cardiomyocytes and assessed their effects on 1. cell viability, 2. myofibrillar structure, 3. contractile function, and 4. MAPK- and Akt-signaling alone or in combination with Doxorubicin. Neither CGP nor PKI induced cardiomyocyte necrosis or apoptosis. PKI but not CGP caused myofibrillar structural damage that was additive to that induced by Doxorubicin at clinically relevant doses. These changes were associated with an inhibition of excitation-contraction coupling. PKI but not CGP decreased p-Erk1/2, suggesting a role for this MAP-kinase signaling pathway in the maintenance of myofibrils. These data indicate that the ErbB2 signaling pathway is critical for the maintenance of myofibrillar structure and function. Clinical studies using ErbB2-targeted inhibitors for the treatment of cancer should be designed to include careful monitoring for cardiac dysfunction.

  11. High-grain diet feeding altered the composition and functions of the rumen bacterial community and caused the damage to the laminar tissues of goats.

    Science.gov (United States)

    Zhang, R Y; Jin, W; Feng, P F; Liu, J H; Mao, S Y

    2018-03-19

    In the current intensive production system, ruminants are often fed high-grain (HG) diets. However, this feeding pattern often causes rumen metabolic disorders and may further trigger laminitis, the exact mechanism is not clear. This study investigated the effect of HG diet feeding on fermentative and microbial changes in the rumen and on the expression of pro-inflammatory cytokines and matrix metalloproteinases (MMPs) in the lamellar tissue. In all, 12 male goats were fed a hay diet (0% grain; n=6) or an HG diet (56.5% grain; n=6). On day 50 of treatment, samples of blood, rumen content, and lamellar tissue of hooves of goats were collected. The data showed that compared with the hay group, HG-fed goats had lower (Pdiet feeding altered the composition of rumen bacterial community, and correspondingly, the results suggested that their functions in the HG group were also altered. HG diet feeding increased (Pbacterial community, and lead to higher levels of LPS in the peripheral blood, and further activated the inflammatory response in lamellar tissues, which may progress to the level of laminar damage.

  12. Quantitative and qualitative damage caused by Oebalus poecilus (Hemiptera, Pentatomidae to upland rice cultivated in new agricultural frontier of the Amazon rainforest (Brazil

    Directory of Open Access Journals (Sweden)

    Diones Krinski

    Full Text Available ABSTRACT Oebalus poecilus (Dallas 1851 is one of the stink bug species of great economic importance for rice producers in Brazil of irrigated, flood and upland cropping systems. These pentatomids are known as stink bugs of panicles, because both nymphs and adults feed mainly on panicles. Stink bug attacks result in pecky (spots seeds, lower mass, germinative reduction and deformed grains. Bearing these factors in mind, the aim of this study was to evaluate the quantitative and qualitative losses in commercial cultivars of upland rice (Cambará variety, submitted to different population levels of stink bugs of panicles, O. poecilus, at different reproductive growth stages. The results show that in upland rice (Cambará variety, the rice grains are susceptible to quantitative (number and weight and qualitative (pecky, atrophy, chalky and broken grains damage during all panicle development. However, when the insects feed during anthesis/caryopsis and milky stage cause significantly greater percentage of empty grains (up to 83% than when they feed of grains during later phases of panicle development. This characteristic was also observed for the reduction in grain weight. This information may benefit producers and other researchers, allowing them to focus on the monitoring efforts of O. poecilus in most susceptible phases of the attack of this insect. This will enable decision-making about what control measures should be taken, and when, in order to control stink bugs of panicles.

  13. Dental practitioners and ill health retirement: a qualitative investigation into the causes and effects.

    Science.gov (United States)

    Hill, K B; Burke, F J T; Brown, J; Macdonald, E B; Morris, A J; White, D A; Murray, K

    2010-09-11

    Data published in 1999 from the Government Actuary on the National Health Service Pension Scheme (1989-1994) have indicated that the frequency of ill health premature retirement (IHR) was four times more prevalent among dentists at age 42 years compared with doctors.Objective The aim of this project was to determine the factors that contributed to IHR in dental practitioners, and the effects of IHR on their lives. Semi-structured interviews were carried out during 2007. A topic list was developed, piloted and used to guide the interviewer. A purposive sampling technique was used to recruit the respondents from an insurance company database. A framework approach to data analysis was utilised. Twenty-three respondents were interviewed, 19 male and 4 female, aged between 39-59 years. Depression, stress and anxiety were reported by respondents to be major causes of their retirement, followed by musculoskeletal disease and premature disability caused by trauma. This is illustrated by the following: '...just went straight into general practice but with some regrets. Practice was so depressing' (GDS/NHS); 'I withdraw, I don't engage ... I found it more and more difficult and one morning... I collapsed in tears at the practice' (GDS/NHS). Dentists reported both negative and positive comments in relation to support received from their health insurance company. The main causes of IHR were depression, musculoskeletal disease and specific skin conditions. Respondents expressed concern regarding the level of support available to dentists in distress. Respondents to this study found that continuing to work had a positive impact on their health.

  14. Political Economy, Capability Development, and Fundamental Cause: Integrating Perspectives on Child Health in Developing Countries

    Directory of Open Access Journals (Sweden)

    Rebekah Burroway

    2017-02-01

    Full Text Available Several dominant theoretical perspectives attempt to account for health disparities in developing countries, including political economy, the capability approach, and fundamental cause. This study combines the perspectives in a multi-level analysis of child malnutrition and diarrhea in order to gain a more comprehensive understanding of who faces increased health risks and who is shielded from them. Using the Demographic and Health Surveys and World Bank data, I estimate a series of models that predict the likelihood of child malnutrition and diarrhea, based on a set of country- and individual-level explanatory variables. Results suggest that at the individual-level, household wealth and maternal education are the most robust predictors of child health. These social factors are even more important than more proximate factors like clean water or sanitation. At the country-level, gross domestic product (GDP per capita reduces malnutrition, but does not significantly affect incidence of diarrhea. Contrary to the predominant economic development paradigm, health care and education are more important in accounting for the prevalence of diarrhea than GDP. Finally, trade in and of itself is not harmful to well-being in developing countries. It is when countries become too dependent on one or a few commodities that trade starts to have detrimental costs. Thus, a synthesis of theoretical frameworks best illustrates the complex web of social structural factors that manifest as unequal life chances for children.

  15. Characterization of hospitalizations due to external causes in the public health system, Brazil, 2011.

    Science.gov (United States)

    Mascarenhas, Márcio Dênis Medeiros; Barros, Marilisa Berti de Azevedo

    2015-01-01

    The aim of this work is to describe the characteristics of hospital admissions owing to external causes in the public health system in Brazil in 2011. Data from the Hospital Information System of the Unified Health System (SIH/SUS) were analyzed to obtain the frequency, coefficient of hospitalization, and hospital morbidity indicators. Of the 973,015 admissions, falls (38.4%) predominated, followed by traffic accidents (15.8%). The estimated coefficient of hospitalization owing to external causes increased with the age, and it was higher in male patients and in the midwest region of the country. The average stay was higher in hospitalizations for traffic accidents (6.1 days) and assaults (6.0 days), while the hospital mortality rate reached higher values in hospitalizations for assaults (4.7%) and self-harms (4.0%). It is evident from the knowledge of the characteristics described the usefulness of hospital morbidity data for planning care actions and prevention of the external causes.

  16. Preventive Effect of the Korean Traditional Health Drink (Taemyeongcheong) on Acetaminophen-Induced Hepatic Damage in ICR Mice.

    Science.gov (United States)

    Yi, Ruo-Kun; Song, Jia-Le; Lim, Yaung-Iee; Kim, Yong-Kyu; Park, Kun-Young

    2015-03-01

    This study was to investigate the preventive effect of taemyeongcheong (TMC, a Korean traditional health drink) on acetaminophen (APAP, 800 mg/kg BW)-induced hepatic damage in ICR mice. TMC is prepared from Saururus chinensis, Taraxacum officinale, Zingiber officinale, Cirsium setidens, Salicornia herbacea, and Glycyrrhizae. A high dose of TMC (500 mg/kg BW) was found to decrease APAP-induced increases in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase. TMC pretreatment also increased the hepatic levels of hepatic catalase, superoxide dismutase, glutathione peroxidase, and glutathione, and reduced serum levels of the inflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6 in mice administered APAP (Phepatic mRNA levels of TNF-α, IL-1β, IL-6, COX-2, and iNOS by 87%, 84%, 89%, 85%, and 88%, respectively, in mice treated with APAP (Phepatic damage.

  17. Investigations of nephrotoxicity caused by ionic and non-ionic contrast media in rats with previously damaged and not previously damaged kidneys and special view to urinary enzyme determinations

    International Nuclear Information System (INIS)

    Hofmeister, R.

    1988-01-01

    In this study ionic (meglumine amidotrizoate) and non-ionic contrast media (SHH 340 AB, Iohexol, Iopromide, Iosimide and Iopamidol) were tested for their nephrotoxicity in rats. During the experiment detections of urea nitrogen, serum creatinine and urinary enzymes as well as histological examinations of the kidneys were carried out for the diagnosis of acute renal damage. The results obtained in this study demonstrate that rats are not very sensitive to non-ionic contrast media with regard to kidney damage and determinations of urinary enzymes are valuable for the diagnosis of contrast media induced acute kidney damage in living animals. (orig./MG) [de

  18. Technical solutions for mitigating security threats caused by health professionals in clinical settings.

    Science.gov (United States)

    Fernandez-Aleman, Jose Luis; Belen Sanchez Garcia, Ana; Garcia-Mateos, Gines; Toval, Ambrosio

    2015-08-01

    The objective of this paper is to present a brief description of technical solutions for health information system security threats caused by inadequate security and privacy practices in healthcare professionals. A literature search was carried out in ScienceDirect, ACM Digital Library and IEEE Digital Library to find papers reporting technical solutions for certain security problems in information systems used in clinical settings. A total of 17 technical solutions were identified: measures for password security, the secure use of e-mail, the Internet, portable storage devices, printers and screens. Although technical safeguards are essential to the security of healthcare organization's information systems, good training, awareness programs and adopting a proper information security policy are particularly important to prevent insiders from causing security incidents.

  19. Novel Damage Detection Techniques for Structural Health Monitoring Using a Hybrid Sensor

    Directory of Open Access Journals (Sweden)

    Dengjiang Wang

    2016-01-01

    Full Text Available This study presents a technique for detecting fatigue cracks based on a hybrid sensor monitoring system consisting of a combination of intelligent coating monitoring (ICM and piezoelectric transducer (PZT sensors. An experimental procedure using this hybrid sensor system was designed to monitor the cracks generated by fatigue testing in plate structures. A probability of detection (POD model that quantifies the reliability of damage detection for a specific sensor or the nondestructive testing (NDT method was used to evaluate the weight factor for the ICM and PZT sensors. To estimate the uncertainty of model parameters in this study, the Bayesian method was employed. Realistic data from fatigue testing was used to validate the overall method, and the results show that the novel damage detection technique using a hybrid sensor can quantify fatigue cracks more accurately than results obtained by conventional sensor methods.

  20. Choropampa case: mercury spilland damage to health in rural exppsed population

    OpenAIRE

    Arana-Zegarra, Marco; Teólogo. Máster en Sociología. Diplomado en Agua y Saneamiento. Diplomado en Gerencia Social. Miembro del Consejo Directivo de la Red Muqui y ex Director de la ONG Grupo de formación e Intervención para el Desarrollo Sostenible. Cajamarca, Perú.

    2009-01-01

    In 2000, a spill of metallic mercury is evaporated into the atmosphere, and it affected the health of over a thousand peasants, who, eight years later, still are suffering the consequences on their health. Modern mining does not guarantee an adequate management, control and mitigation of environmental impacts and public authority does not grant the right to health of populations in environments which miners from the point of view of the right to environmental health should be sites consid...

  1. A Multidisciplinary Approach to Health Monitoring and Materials Damage Prognosis for Metallic Aerospace Systems

    Science.gov (United States)

    2013-03-01

    50 signals were used from Figure 24. Fatigue damage classification in an aluminum lug joint specimen using PZT sensor data without and with...modeling, the single fatigue crack is assumed to be non-breathing during the deformation of the beam. The surface-bonded piezoceramic ( PZT ) actuator...25. Beam with a single fatigue crack under PZT actuation and temperature variations. 20 beam through material expansionis negligible compared

  2. Model-Based Structural Health Monitoring of Fatigue Damage Test-Bed Specimens

    Science.gov (United States)

    2011-11-15

    the hull welds or notches along component edges are good initial candidates for the hypothetical damage initiation areas. The branching process adds...to it off-center. The base plate and the stiffener plate are rigidly welded by a tungsten inert gas ( TIG ) weld . Three different crack paths...shown in Figure 9(a), an 18 in long stiffener plate has been welded to each of the tested plates with 0.625 in long discrete TIG welds at 5 locations

  3. Automatic recognition of damaged town buildings caused by earthquake using remote sensing information: Taking the 2001 Bhuj, India, earthquake and the 1976 Tangshan, China, earthquake as examples

    Science.gov (United States)

    Liu, Jia-Hang; Shan, Xin-Jian; Yin, Jing-Yuan

    2004-11-01

    In the high-resolution images, the undamaged buildings generally show a natural textural feature, while the damaged or semi-damaged buildings always exhibit some low-grayscale blocks because of their coarsely damaged sections. If we use a proper threshold to classify the grayscale of image, some independent holes will appear in the damaged regions. By using such statistical information as the number of holes in every region, or the ratio between the area of holes and that of the region, etc, the damaged buildings can be separated from the undamaged, thus automatic detection of damaged buildings can be realized. Based on these characteristics, a new method to automatically detect the damage buildings by using regional structure and statistical information of texture is presented in the paper. In order to test its validity, 1-m-resolution iKonos merged image of the 2001 Bhuj earthquake and grayscale aerial photos of the 1976 Tangshan earthquake are selected as two examples to automatically detect the damaged buildings. Satisfied results are obtained.

  4. Association between changes in lifestyle and all-cause mortality: the Health and Lifestyle Survey.

    OpenAIRE

    White, J.; Greene, G.; Kivimaki, M.; Batty, G. D.

    2018-01-01

    BACKGROUND: To examine the combined influence of changes in physical activity, diet, smoking and alcohol consumption on all-cause mortality. METHODS: Health behaviours were assessed in 1984/1985 and 1991/1992 in 8123 adults from the UK (4666 women, median age 41.0 years). An unhealthy lifestyle score was calculated, allocating one point for smoking, fruits and vegetables 21 units of alcohol (men) per week. RESULTS: There were 2003 deaths over a median follow-up of 6.6 years (IQR 5.9-7.2) foll...

  5. Concerns and perceptions immediately following Superstorm Sandy: ratings for property damage were higher than for health issues.

    Science.gov (United States)

    Burger, Joanna; Gochfeld, Michael

    Governmental officials, health and safety professionals, early responders, and the public are interested in the perceptions and concerns of people faced with a crisis, especially during and immediately after a disaster strikes. Reliable information can lead to increased individual and community preparedness for upcoming crises. The objective of this research was to evaluate concerns of coastal and central New Jersey residents within the first 100 days of Superstorm Sandy's landfall. Respondents living in central New Jersey and Jersey shore communities were differentially impacted by the storm, with shore residents having higher evacuation rates (47% vs. 13%), more flood waters in their homes, longer power outages (average 23 vs. 6 days), and longer periods without Internet (29 vs. 6 days). Ratings of concerns varied both among and within categories as a function of location (central vs. coastal New Jersey), stressor level (ranging from 1 to 3 for combinations of power outages, high winds, and flooding), and demographics. Respondents were most concerned about property damage, health, inconveniences, ecological services, and nuclear power plants in that order. Respondents from the shore gave higher ratings to the concerns within each major category, compared to those from central Jersey. Four findings have implications for understanding future risk, recovery, and resiliency: (1) respondents with the highest stressor level (level 3) were more concerned about water damage than others, (2) respondents with flood damage were more concerned about water drainage and mold than others, (3) respondents with the highest stressor levels rated all ecological services higher than others, and (4) shore respondents rated all ecological services higher than central Jersey residents. These data provide information to design future preparedness plans, improve resiliency for future severe weather events, and reduce public health risk.

  6. Record-low primary productivity and high plant damage in the Nordic Arctic Region in 2012 caused by multiple weather events and pest outbreaks

    International Nuclear Information System (INIS)

    Bjerke, Jarle W; Jepsen, Jane U; Lovibond, Sarah; Tømmervik, Hans; Rune Karlsen, Stein; Arild Høgda, Kjell; Malnes, Eirik; Vikhamar-Schuler, Dagrun

    2014-01-01

    The release of cold temperature constraints on photosynthesis has led to increased productivity (greening) in significant parts (32–39%) of the Arctic, but much of the Arctic shows stable (57–64%) or reduced productivity (browning, <4%). Summer drought and wildfires are the best-documented drivers causing browning of continental areas, but factors dampening the greening effect of more maritime regions have remained elusive. Here we show how multiple anomalous weather events severely affected the terrestrial productivity during one water year (October 2011–September 2012) in a maritime region north of the Arctic Circle, the Nordic Arctic Region, and contributed to the lowest mean vegetation greenness (normalized difference vegetation index) recorded this century. Procedures for field data sampling were designed during or shortly after the events in order to assess both the variability in effects and the maximum effects of the stressors. Outbreaks of insect and fungal pests also contributed to low greenness. Vegetation greenness in 2012 was 6.8% lower than the 2000–11 average and 58% lower in the worst affected areas that were under multiple stressors. These results indicate the importance of events (some being mostly neglected in climate change effect studies and monitoring) for primary productivity in a high-latitude maritime region, and highlight the importance of monitoring plant damage in the field and including frequencies of stress events in models of carbon economy and ecosystem change in the Arctic. Fourteen weather events and anomalies and 32 hypothesized impacts on plant productivity are summarized as an aid for directing future research. (letter)

  7. The Snow Must Go On: Ground Ice Encasement, Snow Compaction and Absence of Snow Differently Cause Soil Hypoxia, CO2 Accumulation and Tree Seedling Damage in Boreal Forest.

    Science.gov (United States)

    Martz, Françoise; Vuosku, Jaana; Ovaskainen, Anu; Stark, Sari; Rautio, Pasi

    2016-01-01

    At high latitudes, the climate has warmed at twice the rate of the global average with most changes observed in autumn, winter and spring. Increasing winter temperatures and wide temperature fluctuations are leading to more frequent rain-on-snow events and freeze-thaw cycles causing snow compaction and formation of ice layers in the snowpack, thus creating ice encasement (IE). By decreasing the snowpack insulation capacity and restricting soil-atmosphere gas exchange, modification of the snow properties may lead to colder soil but also to hypoxia and accumulation of trace gases in the subnivean environment. To test the effects of these overwintering conditions changes on plant winter survival and growth, we established a snow manipulation experiment in a coniferous forest in Northern Finland with Norway spruce and Scots pine seedlings. In addition to ambient conditions and prevention of IE, we applied three snow manipulation levels: IE created by artificial rain-on-snow events, snow compaction and complete snow removal. Snow removal led to deeper soil frost during winter, but no clear effect of IE or snow compaction done in early winter was observed on soil temperature. Hypoxia and accumulation of CO2 were highest in the IE plots but, more importantly, the duration of CO2 concentration above 5% was 17 days in IE plots compared to 0 days in ambient plots. IE was the most damaging winter condition for both species, decreasing the proportion of healthy seedlings by 47% for spruce and 76% for pine compared to ambient conditions. Seedlings in all three treatments tended to grow less than seedlings in ambient conditions but only IE had a significant effect on spruce growth. Our results demonstrate a negative impact of winter climate change on boreal forest regeneration and productivity. Changing snow conditions may thus partially mitigate the positive effect of increasing growing season temperatures on boreal forest productivity.

  8. The responsibility of the agents responsible for environmental damage caused by oil spilling in Brazil; A responsabilidade dos agentes causadores de dano ambiental por derramamento de oleo no Brasil

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This essay talks about the responsibility of the agents that cause damage to the environment, both civil liability, as well as criminal and administrative responsibility. It analyzes the most important brazilian juridical rules, emphasizing the National Environmental Politics Law, the Brazilian Federal Republic Constitution and the Environmental Crimes Law. Specially, due to the amount and importance of the oil and gas activities in Brazil, it talks about the environmental responsibility, in the above mentioned fields, related to damage resulting from the Oil and Gas Industry's activities. It focuses the rules that rule this subject in the brazilian juridical system, emphasizing the cases of environmental damage resulting from oil spills in Brazil and the probable juridical consequences to the agents responsible for this damage. (author)

  9. Study of damages caused by drill fluids in sandstone samples using energy dispersive X-ray fluorescence (EDXRF); Estudo dos danos causados por fluido de perfuracao em amostras de arenito utilizando a fluorescencia de raios X dispersiva em energia (EDXRF)

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro, Joao Luiz B.; Lopes, Ricardo T.; Anjos, Marcelino J. dos; Leite, Jaques C. [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia. Lab. de Instrumentacao Nuclear; Queiroz Neto, Joao C. [PETROBRAS, Rio de Janeiro, RJ (Brazil). Centro de Pesquisas

    2002-07-01

    The performance of an X ray fluorescence (EDXRF) system was evaluated for the determination of solids invasion profile. The EDXRF was used to identify the elements, that are present in the rock core after the damage tests. Results are presented of an experimental study of formation permeability damage caused by invasion of the inert and extraneous solids simulated by CaCO{sub 3} particles. Laboratory damage tests were performed using two types of sandstones core. Vila Velha, low permeability (15 mD) and Rio Bonito, high permeability (800 mD). The damage tests were performed with utilization of SIRF-P, which simulates the conditions find in-situ (petroleum well). (author)

  10. Prevalence and causes of hearing impairment in Fundong Health District, North-West Cameroon.

    Science.gov (United States)

    Ferrite, Silvia; Mactaggart, Islay; Kuper, Hannah; Oye, Joseph; Polack, Sarah

    2017-04-01

    To estimate the prevalence and causes of hearing impairment in Fundong Health District, North-West Cameroon. We selected 51 clusters of 80 people (all ages) through probability proportionate to size sampling. Initial hearing screening was undertaken through an otoacoustic emission (OAE) test. Participants aged 4+ years who failed this test in both ears or for whom an OAE reading could not be taken underwent a manual pure-tone audiometry (PTA) screening. Cases of hearing impairment were defined as those with pure-tone average ≥41 dBHL in adults and ≥35 dBHL in children in the better ear, or children under age 4 who failed the OAE test in both ears. Each case with hearing loss was examined by an ear, nose and throat nurse who indicated the main likely cause. We examined 3567 (86.9%) of 4104 eligible people. The overall prevalence of hearing impairment was 3.6% (95% confidence interval [CI]: 2.8-4.6). The prevalence was low in people aged 0-17 (1.1%, 0.7-1.8%) and 18-49 (1.1%, 0.5-2.6%) and then rose sharply in people aged 50+ (14.8%, 11.7-19.1%). Among cases, the majority were classified as moderate (76%), followed by severe (15%) and profound (9%). More than one-third of cases of hearing impairment were classified as unknown (37%) or conductive (37%) causes, while sensorineural causes were less common (26%). Prevalence of hearing impairment in North-West Cameroon is in line with the WHO estimate for sub-Saharan Africa. The majority of cases with known causes are treatable, with impacted wax playing a major role. © 2017 John Wiley & Sons Ltd.

  11. Root causes investigation of catastrophic optical bulk damage in high-power InGaAs-AlGaAs strained QW lasers

    Science.gov (United States)

    Sin, Yongkun; Lingley, Zachary; Ayvazian, Talin; Brodie, Miles; Ives, Neil

    2018-02-01

    High-power single-mode (SM) and multi-mode (MM) InGaAs-AlGaAs strained quantum well (QW) lasers are critical components for both terrestrial and space satellite communications systems. Since these lasers predominantly fail by catastrophic and sudden degradation due to COD, it is especially crucial for space satellite applications to investigate reliability, failure modes, and degradation mechanisms of these lasers. Our group reported a new failure mode in MM and SM InGaAs-AlGaAs strained QW lasers in 2009 and 2016, respectively. Our group also reported in 2017 that bulk failure due to catastrophic optical bulk damage (COBD) is the dominant failure mode of both SM and MM lasers that were subject to long-term life-tests. For the present study, we report root causes investigation of COBD by performing long-term lifetests followed by failure mode analysis (FMA) using various micro-analytical techniques including electron beam induced current (EBIC), time-resolved electroluminescence (EL), focused ion beam (FIB), high-resolution transmission electron microscopy (TEM), and deep level transient spectroscopy (DLTS). Our life-tests with accumulated test hours of over 25,000 hours for SM lasers and over 35,000 hours for MM lasers generated a number of COBD failures with various failure times. EBIC techniques were employed to study dark line defects (DLDs) generated in SM COBD failures stressed under different test conditions. FIB and high-resolution TEM were employed to prepare cross sectional and plan view TEM specimens to study DLD areas (dislocations) in post-aged SM lasers. Time-resolved EL techniques were employed to study initiation and progressions of dark spots and dark lines in real time as MM lasers were aged. Lastly, to investigate precursor signatures of failure and degradation mechanisms responsible for COBD in both SM and MM lasers, we employed DLTS techniques to study a role that electron traps (non-radiative recombination centers) play in degradation of these

  12. Multi-site damage localization in anisotropic plate-like structures using an active guided wave structural health monitoring system

    International Nuclear Information System (INIS)

    Moll, J; Schulte, R T; Fritzen, C-P; Hartmann, B; Nelles, O

    2010-01-01

    A new approach for structural health monitoring using guided waves in plate-like structures has been developed. In contrast to previous approaches, which mainly focused on isotropic or quasi-isotropic plates, the proposed algorithm does not assume any simplifications regarding anisotropic wave propagation. Thus, it can be used to improve the probability of detection. In this paper the mathematical background for damage localization in anisotropic plates will be introduced. This is an extension of the widely known ellipse method. The formalism is based on a distributed sensor network, where each piezoelectric sensor acts in turn as an actuator. The automatic extraction of the onset time of the first waveform in the differential signal in combination with a statistical post-processing via a two-dimensional probability density function and the application of the expectation-maximization algorithm allows a completely automatic localization procedure. Thus, multiple damages can be identified at the same time. The present study uses ultrasonic signals provided by the spectral element method. This simulation approach shows good agreement with experimental measurements. A local linear neural network is used to model the nonlinear dispersion curves. The benefit of using a neural network approach is to increase the angular resolution that results from the sparse sensor network. Furthermore, it can be used to shorten the computational time for the damage localization procedure

  13. Allostatic load as a predictor of all-cause and cause-specific mortality in the general population: Evidence from the Scottish Health Survey.

    Science.gov (United States)

    Robertson, Tony; Beveridge, Gayle; Bromley, Catherine

    2017-01-01

    Allostatic load is a multiple biomarker measure of physiological 'wear and tear' that has shown some promise as marker of overall physiological health, but its power as a risk predictor for mortality and morbidity is less well known. This study has used data from the 2003 Scottish Health Survey (SHeS) (nationally representative sample of Scottish population) linked to mortality records to assess how well allostatic load predicts all-cause and cause-specific mortality. From the sample, data from 4,488 men and women were available with mortality status at 5 and 9.5 (rounded to 10) years after sampling in 2003. Cox proportional hazard models estimated the risk of death (all-cause and the five major causes of death in the population) according to allostatic load score. Multiple imputation was used to address missing values in the dataset. Analyses were also adjusted for potential confounders (sex, age and deprivation). There were 258 and 618 deaths over the 5-year and 10-year follow-up period, respectively. In the fully-adjusted model, higher allostatic load (poorer physiological 'health') was not associated with an increased risk of all-cause mortality after 5 years (HR = 1.07, 95% CI 0.94 to 1.22; p = 0.269), but it was after 10 years (HR = 1.08, 95% CI 1.01 to 1.16; p = 0.026). Allostatic load was not associated with specific causes of death over the same follow-up period. In conclusions, greater physiological wear and tear across multiple physiological systems, as measured by allostatic load, is associated with an increased risk of death, but may not be as useful as a predictor for specific causes of death.

  14. Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing

    Directory of Open Access Journals (Sweden)

    Kirsty Porter

    2016-11-01

    Full Text Available The potential protective roles of folate and the metabolically related B-vitamins (vitamins B12, B6 and riboflavin in diseases of ageing are of increasing research interest. The most common cause of folate and riboflavin deficiencies in older people is low dietary intake, whereas low B12 status is primarily associated with food-bound malabsorption, while sub-optimal vitamin B6 status is attributed to increased requirements in ageing. Observational evidence links low status of folate and the related B-vitamins (and/or elevated concentrations of homocysteine with a higher risk of degenerative diseases including cardiovascular disease (CVD, cognitive dysfunction and osteoporosis. Deficient or low status of these B-vitamins alone or in combination with genetic polymorphisms, including the common MTHFR 677 C → T polymorphism, could contribute to greater disease risk in ageing by causing perturbations in one carbon metabolism. Moreover, interventions with the relevant B-vitamins to optimise status may have beneficial effects in preventing degenerative diseases. The precise mechanisms are unknown but many have been proposed involving the role of folate and the related B-vitamins as co-factors for one-carbon transfer reactions, which are fundamental for DNA and RNA biosynthesis and the maintenance of methylation reactions. This review will examine the evidence linking folate and related B-vitamins with health and disease in ageing, associated mechanisms and public health implications.

  15. An estimation of the health impact of groundwater pollution caused by dumping of chlorinated solvents

    International Nuclear Information System (INIS)

    Lee, Lukas Jyuhn-Hsiarn; Chen, Chien-Hung; Chang, Yu-Yin; Liou, Saou-Hsing; Wang, Jung-Der

    2010-01-01

    Background: Hazardous waste sites are major environmental concerns, but few studies have quantified their expected utility loss on health. Objectives: To evaluate the health impact of groundwater pollution by an electronics manufacturing factory, we conducted a health risk assessment based on expected utility loss from liver cancer. Methods: Based on measurements of major pollutants, we estimated the likelihood of developing liver cancer after exposure to groundwater contamination. All patients with liver cancer between 1990 and 2005 in the Taiwan Cancer Registry were followed through 2007 using the National Mortality Registry to obtain survival function. Quality of life was assessed with two cross-sectional surveys, one employing the standard gamble method, and the other using the EQ-5D instrument. Quality-adjusted life expectancy (QALE) was estimated by multiplying the utility values with survival function under the unit of quality-adjusted life year (QALY). The difference of QALE between the cancer cohort and the age- and gender-matched reference population was calculated to represent the utility loss due to liver cancer. Results: A total of 94,144 patients with liver cancer were identified. The average utility loss to development of liver cancer was 17.5 QALYs. Based on toxicological approach, we estimated that groundwater pollution caused 1.7 extra cases of liver cancer, with an overall loss of 29.8 QALYs. Based on epidemiological approach, the expected annual excess number of liver cancer would be 3.65, which would have been accumulated through the years, had the pollution not mitigated. Conclusions: We demonstrated a practical approach for comparative health risk assessment using QALY as the common unit. This approach can be used for policy decisions based on possible health risks.

  16. An estimation of the health impact of groundwater pollution caused by dumping of chlorinated solvents

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Lukas Jyuhn-Hsiarn [Department of Environmental and Occupational Medicine, National Taiwan University Hospital, Taipei, Taiwan (China); Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan (China); Chen, Chien-Hung [Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (China); Chang, Yu-Yin [Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan (China); Liou, Saou-Hsing [Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan (China); Wang, Jung-Der, E-mail: jdwang@ntu.edu.tw [Department of Environmental and Occupational Medicine, National Taiwan University Hospital, Taipei, Taiwan (China); Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan (China); Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (China)

    2010-02-15

    Background: Hazardous waste sites are major environmental concerns, but few studies have quantified their expected utility loss on health. Objectives: To evaluate the health impact of groundwater pollution by an electronics manufacturing factory, we conducted a health risk assessment based on expected utility loss from liver cancer. Methods: Based on measurements of major pollutants, we estimated the likelihood of developing liver cancer after exposure to groundwater contamination. All patients with liver cancer between 1990 and 2005 in the Taiwan Cancer Registry were followed through 2007 using the National Mortality Registry to obtain survival function. Quality of life was assessed with two cross-sectional surveys, one employing the standard gamble method, and the other using the EQ-5D instrument. Quality-adjusted life expectancy (QALE) was estimated by multiplying the utility values with survival function under the unit of quality-adjusted life year (QALY). The difference of QALE between the cancer cohort and the age- and gender-matched reference population was calculated to represent the utility loss due to liver cancer. Results: A total of 94,144 patients with liver cancer were identified. The average utility loss to development of liver cancer was 17.5 QALYs. Based on toxicological approach, we estimated that groundwater pollution caused 1.7 extra cases of liver cancer, with an overall loss of 29.8 QALYs. Based on epidemiological approach, the expected annual excess number of liver cancer would be 3.65, which would have been accumulated through the years, had the pollution not mitigated. Conclusions: We demonstrated a practical approach for comparative health risk assessment using QALY as the common unit. This approach can be used for policy decisions based on possible health risks.

  17. Bisphenol A Causes Liver Damage and Selectively Alters the Neurochemical Coding of Intrahepatic Parasympathetic Nerves in Juvenile Porcine Models under Physiological Conditions

    Directory of Open Access Journals (Sweden)

    Michael Thoene

    2017-12-01

    Full Text Available Bisphenol A (BPA is an extremely common polymer that is used in typical everyday products throughout the world, especially in food and beverage containers. Within the last ten years, it has been found that the BPA monomer tends to leach into foodstuffs, and nanogram concentrations of it may cause a variety of deleterious health effects. These health problems are very evident in developing children and in young adults. The aim of this study was to expose developing pigs to dietary BPA at both legally acceptable and ten-fold higher levels. Livers that had been exposed to BPA showed vacuolar degeneration, sinusoidal dilatation, vascular congestion and glycogen depletion that increased with exposure levels. Furthermore, the livers of these models were then examined for irregularities and double-labeled immunofluorescence was used to check the innervated hepatic samples for varying neuronal expression of selected neuronal markers in the parasympathetic nervous system (PSNS. It was found that both the PSNS and all of the neuronal markers showed increased expression, with some of them being significant even at recommended safe exposure levels. The implications are quite serious since these effects have been observed at recommended safe levels with expression increasing in-line with exposure levels. The increased neuronal markers studied here have been previously correlated with behavioral/psychological disorders of children and young adults, as well as with childhood obesity and diabetes. However, further research must be performed in order to develop a mechanism for the above-mentioned correlations.

  18. Damage Characterization and Real-Time Health Monitoring of Aerospace Materials Using Innovative NDE Tools

    Science.gov (United States)

    Matikas, Theodore E.

    2010-07-01

    The objective of this work is to characterize the damage and monitor in real-time aging structural components used in aerospace applications by means of advanced nondestructive evaluation techniques. Two novel experimental methodologies are used in this study, based on ultrasonic microscopy and nonlinear acoustics. It is demonstrated in this work that ultrasonic microscopy can be successfully utilized for local elastic property measurement, crack-size determination as well as for interfacial damage evaluation in high-temperature materials, such as metal matrix composites. Nonlinear acoustics enables real-time monitoring of material degradation in aerospace structures. When a sinusoidal ultrasonic wave of a given frequency and of sufficient amplitude is introduced into a nonharmonic solid, the fundamental wave distorts as it propagates, and therefore the second and higher harmonics of the fundamental frequency are generated. Measurements of the amplitude of these harmonics provide information on the coefficient of second- and higher-order terms of the stress-strain relation for a nonlinear solid. It is shown in this article that the material bulk nonlinear parameter for metallic alloy samples at different fatigue levels exhibits large changes compared to linear ultrasonic parameters, such as velocity and attenuation.

  19. Damage of the Unit 1 reactor building overhead bridge crane at Onagawa Nuclear Power Station caused by the Great East Japan Earthquake and its repair works

    International Nuclear Information System (INIS)

    Sugamata, Norihiko

    2014-01-01

    The driving shaft bearings of the Unit 1 overhead bridge crane were damaged by the Great East Japan Earthquake at Onagawa Nuclear Power Station. The situation, investigation and repair works of the bearing failure are introduced in this paper. (author)

  20. The causes of bullying: results from the National Survey of School Health (PeNSE

    Directory of Open Access Journals (Sweden)

    Wanderlei Abadio de Oliveira

    2015-04-01

    Full Text Available Objective: to identify the characteristics and reasons reported by Brazilian students for school bullying. Method: this cross-sectional study uses data from an epidemiological survey (National Survey of School Health conducted in 2012. A total of 109,104 9th grade students from private and public schools participated. Data were collected through a self-applied questionnaire and the analysis was performed using SPSS, version 20, Complex Samples Module. Results: the prevalence of bullying was 7.2%, most frequently affecting Afro-descendant or indigenous younger boys, whose mothers were characterized by low levels of education. In regard to the reasons/causes of bullying, 51.2% did not specify; the second highest frequency of victimization was related to body appearance (18.6%; followed by facial appearance (16.2%; race/color (6.8%; sexual orientation 2.9%; religion 2.5%; and region of origin 1.7%. The results are similar to those found in other sociocultural contexts. Conclusion: the problem belongs to the health field because it gathers aspects that determine the students' health-disease-care continuum.

  1. [Risks and health problems caused by the use of video terminals].

    Science.gov (United States)

    Tamez González, Silvia; Ortiz-Hernández, Luis; Martínez-Alcántara, Susana; Méndez-Ramírez, Ignacio

    2003-01-01

    To evaluate the association between video display terminal (VDT) use and health hazards, occupational risks, and psychosocial factors, in newspaper workers. A cross-sectional study was conducted in 1998 in a representative sample (n = 68) drawn from a population of 218 VDT operators in Mexico City. Data were collected using a self-administered questionnaire. Data were confirmed by performing physical examinations. The research hypothesis was that both the current and cumulative use of VDT are associated with visual, musculoskeletal system, and skin illnesses, as well as with fatigue and mental or psychosomatic disorders. Occupational health hazards were assessed (visual problems, postural risks, sedentary work, computer mouse use, excessive heat, and overcrowding), as well as psychosocial factors related to work organization (psychological demands, work control, and social support). Prevalence ratios were adjusted for confounding variables like age, sex and schooling. Women were more likely than men to have upper extremity musculoskeletal disorders (MSD), dermatitis, and seborrheic eczema. VDT use was associated with neuro-visual fatigue, upper extremity MSD, dermatitis, and seborrheic eczema. Computer mouse use and postural risks were significantly associated with health problems. Psychosocial factors were mainly associated with mental problems, psychosomatic disorders, and fatigue. Intense use of video screens has been found to cause musculoskeletal disorders of the hand. The diversification of tasks and control of labor processes itself had a protective effect against psychosomatic disorders and pathological fatigue.

  2. Assessment of the State of the Art of Integrated Vehicle Health Management Technologies as Applicable to Damage Conditions

    Science.gov (United States)

    Reveley, Mary S.; Kurtoglu, Tolga; Leone, Karen M.; Briggs, Jeffrey L.; Withrow, Colleen A.

    2010-01-01

    A survey of literature from academia, industry, and other Government agenc