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Sample records for hci-swwa ipw jtres

  1. [Inverse probability weighting (IPW) for evaluating and "correcting" selection bias].

    Science.gov (United States)

    Narduzzi, Silvia; Golini, Martina Nicole; Porta, Daniela; Stafoggia, Massimo; Forastiere, Francesco

    2014-01-01

    the Inverse probability weighting (IPW) is a methodology developed to account for missingness and selection bias caused by non-randomselection of observations, or non-random lack of some information in a subgroup of the population. to provide an overview of IPW methodology and an application in a cohort study of the association between exposure to traffic air pollution (nitrogen dioxide, NO₂) and 7-year children IQ. this methodology allows to correct the analysis by weighting the observations with the probability of being selected. The IPW is based on the assumption that individual information that can predict the probability of inclusion (non-missingness) are available for the entire study population, so that, after taking account of them, we can make inferences about the entire target population starting from the nonmissing observations alone.The procedure for the calculation is the following: firstly, we consider the entire population at study and calculate the probability of non-missing information using a logistic regression model, where the response is the nonmissingness and the covariates are its possible predictors.The weight of each subject is given by the inverse of the predicted probability. Then the analysis is performed only on the non-missing observations using a weighted model. IPW is a technique that allows to embed the selection process in the analysis of the estimates, but its effectiveness in "correcting" the selection bias depends on the availability of enough information, for the entire population, to predict the non-missingness probability. In the example proposed, the IPW application showed that the effect of exposure to NO2 on the area of verbal intelligence quotient of children is stronger than the effect showed from the analysis performed without regard to the selection processes.

  2. ipw: An R Package for Inverse Probability Weighting

    Directory of Open Access Journals (Sweden)

    Ronald B. Geskus

    2011-10-01

    Full Text Available We describe the R package ipw for estimating inverse probability weights. We show how to use the package to fit marginal structural models through inverse probability weighting, to estimate causal effects. Our package can be used with data from a point treatment situation as well as with a time-varying exposure and time-varying confounders. It can be used with binomial, categorical, ordinal and continuous exposure variables.

  3. Ground-Based Global Positioning System (GPS) Meteorology Integrated Precipitable Water Vapor (IPW)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Ground-Based Global Positioning System (GPS) Meteorology Integrated Precipitable Water Vapor (IPW) data set measures atmospheric water vapor using ground-based...

  4. GPS IPW as a Meteorological Parameter and Climate Global Change Indicator

    Science.gov (United States)

    Kruczyk, M.; Liwosz, T.

    2011-12-01

    Paper focuses on comprehensive investigation of the GPS derived IPW (Integrated Precipitable Water, also IWV) as a geophysical tool. GPS meteorology is now widely acknowledged indirect method of atmosphere sensing. First we demonstrate GPS IPW quality. Most thorough inter-technique comparisons of directly measured IPW are attainable only for some observatories (note modest percentage of GPS stations equipped with meteorological devices). Nonetheless we have managed to compare IPW series derived from GPS tropospheric solutions (ZTD mostly from IGS and EPN solutions) and some independent techniques. IPW values from meteorological sources we used are: radiosoundings, sun photometer and input fields of numerical weather prediction model. We can treat operational NWP models as meteorological database within which we can calculate IWV for all GPS stations independently from network of direct measurements (COSMO-LM model maintained by Polish Institute of Meteorology and Water Management was tried). Sunphotometer (CIMEL-318, Central Geophysical Observatory IGF PAS, Belsk, Poland) data seems the most genuine source - so we decided for direct collocation of GPS measurements and sunphotometer placing permanent GPS receiver on the roof of Belsk Observatory. Next we analyse IPW as geophysical parameter: IPW demonstrates some physical effects evoked by station location (height and series correlation coefficient as a function of distance) and weather patterns like dominant wind directions (in case of neighbouring stations). Deficiency of surface humidity data to model IPW is presented for different climates. This inadequacy and poor humidity data representation in NWP model extremely encourages investigating information exchange potential between Numerical Model and GPS network. The second and most important aspect of this study concerns long series of IPW (daily averaged) which can serve as climatological information indicator (water vapour role in climate system is hard to

  5. IPW and ZTD from numerical weather prediction model in the context of GNSS tropospheric products

    Science.gov (United States)

    Kruczyk, M.; Liwosz, T.; Mazur, A.

    2012-04-01

    Paper describes extensive experiences in dealing with operational numerical prediction models treated as a source of IPW and ZTD needed for GNSS tropospheric products quality assessment. Authors use operational numerical prediction model COSMO-LM (maintained by Polish Institute of Meteorology and Water Management) in two different resolution versions: 14 km and 2.8 km and global model GFS (operated by NCEP). Both input fields and first prognosis steps of operational numerical prediction model were processed as IPW source for comparisons and analyses. We discuss diversity of questions concerning precise derivation of IPW and ZTD from model grid e. g.: interpolation of data in space, numerical integration in zenith direction, correction for model topography, physical equations chosen for humidity parameters conversions etc. Results from NWP model are neatly collated with various GNSS tropospheric solutions: WUT EPN LAC solutions, EPN combined product and IGS solutions. Also meteorological water vapour data sources (radiosoundings and sun photometer CIMEL-318) were utilized for independent verification. Presented results of many comparisons lead to some clues about key factors in such calculations. We get also valuable information about GNSS tropospheric solutions quality.

  6. Persistent organic pollutants monitoring in marine coastal environment using beached plastic resin pellets and effective risk communication via International Pellet Watch (IPW) as a tool.

    Science.gov (United States)

    Yeo, B. G. M.; Takada, H.; Hosoda, J.

    2014-12-01

    International Pellet Watch (IPW) is an ongoing global monitoring of persistent organic pollutants (POPs) using preproduction plastic resin pellets. These pellets are easily collected and transported allowing the general public worldwide to get involved. Thus, risk communication toward the pellet collectors is a significant part of IPW to ensure continuous effort and interest. The pellet samples were analyzed for polychlorinated biphenyl (PCBs), dichlorodiphenyltrichloroethane and degradation products (DDTs), and hexachlorocyclohexanes (HCHs). Additional pollutants such as polycyclic aromatic hydrocarbons (PAHs) and Hopanes were also analyzed for some samples. Analytical results showed distinct patterns with high concentrations (pollution where PCBs were used extensively before the ban in the late 1980's. Pesticide DDTs instead were found to be higher in developing countries such as Brazil and Vietnam (> 500ng/g-pellet). These countries may still be using DDTs as a vector control mostly to combat malaria. High concentrations of DDTs were also found in Greece, China and Australia (> 100ng/g-pellet) suggesting the possibility of illegal usage as pesticide or anti fouling paint. HCHs concentrations were mostly low due to its low retention in the environment. However, high HCHs concentrations were mostly found in the southern hemisphere. Very high concentration of PAHs in pellet samples can be utilized for early identification of recent oil pollution. High PAHs concentration in Tauranga, New Zealand was found to be caused by local oil spill. Hopanes in pellets can be used for source identification of oil pollution. Global mapping and comparison among IPW data can be used to provide better explanations to IPW volunteers by sorting concentrations into pollution categories. Communication reports are tailor written based on the volunteers familiarity to IPW's issues, educational background, occupation and their potential to further spread awareness. Based on feedbacks, the

  7. Thermal and salinity signals across the San Lorenzo Sill in the Gulf of California. Are gulfies and IPW cascading down slope already in historical data?

    Science.gov (United States)

    Navarro Olache, L. F.; Robinson, I. S.; Godinez, V. M.

    2007-05-01

    Midscale high salinity structures known as "gulfies" are identified in the central regions of the Gulf of California using all available hydrographic historical data. Cluster of temperature and salinity data are arrayed in a 400 km line from Guaymas basin (26 N,112 W) to the upper limit of Angel de la Guardia Island with the propose of provide evidences of the outflow and inflows in the close proximity to San Lorenzo-San Esteban sill. Based on discrete data analysis three layers of fluid are identified over the sill, two layers in opposite directions and one deep layer of cold inflow (mouth to head), particularly active during winter. The first layer, near surface is a high salinity warm outflow across the sill, from head to mouth, within a depth of 150 m forming eddy like pulses with a form and structure that may be related to "gulfies". The second layer across the sill is in opposite direction (mouth to head). Temperature and salinity data shows that this layer is formed by Subsurface Subtropical Water of Pacific Ocean origin. The third layer cross the sill near bottom (450m), this layer is a cold temperature and low salinity inflow of Pacific Intermediate Water PIW available in the Guaymas Basin apparently with more predominance during winter time. Signal analysis shows that high salinity water outflow progressing over the sill with a velocity of 4 km day-1, apparently with a larger transport during winter. The PIW inflow progress over the sill with a velocity of 0.6 kmday- 1, cascading immediately down the slope one it had crossed the sill. The amount of heat integrated above 500 m reveals that the lowest overall temperature is in the region close to the sill; while the warmer overall temperature is in the west region of the gulf along Ballenas-Salsipuedes channel.

  8. Exploring Powered Wheelchair Users and Their Caregivers’ Perspectives on Potential Intelligent Power Wheelchair Use: A Qualitative Study

    Directory of Open Access Journals (Sweden)

    Dahlia Kairy

    2014-02-01

    Full Text Available Power wheelchairs (PWCs can have a positive impact on user well-being, self-esteem, pain, activity and participation. Newly developed intelligent power wheelchairs (IPWs, allowing autonomous or collaboratively-controlled navigation, could enhance mobility of individuals not able to use, or having difficulty using, standard PWCs. The objective of this study was to explore the perspectives of PWC users (PWUs and their caregivers regarding if and how IPWs could impact on current challenges faced by PWUs, as well as inform current development of IPWs. A qualitative exploratory study using individual interviews was conducted with PWUs (n = 12 and caregivers (n = 4. A semi-structured interview guide and video were used to facilitate informed discussion regarding IPWs. Thematic analysis revealed three main themes: (1 “challenging situations that may be overcome by an IPW” described how the IPW features of obstacle avoidance, path following, and target following could alleviate PWUs’ identified mobility difficulties; (2 “cautious optimism concerning IPW use revealed participants” addresses concerns regarding using an IPW as well as technological suggestions; (3 “defining the potential IPW user” revealed characteristics of PWUs that would benefit from IPW use. Findings indicate how IPW use may help overcome PWC difficulties and confirm the importance of user input in the ongoing development of IPWs.

  9. Long Series of GNSS Integrated Precipitable Water as a Climate Change Indicator

    Directory of Open Access Journals (Sweden)

    Kruczyk Michał

    2015-12-01

    Full Text Available This paper investigates information potential contained in tropospheric delay product for selected International GNSS Service (IGS stations in climatologic research. Long time series of daily averaged Integrated Precipitable Water (IPW can serve as climate indicator. The seasonal model of IPW change has been adjusted to the multi-year series (by the least square method. Author applied two modes: sinusoidal and composite (two or more oscillations. Even simple sinusoidal seasonal model (of daily IPW values series clearly represents diversity of world climates. Residuals in periods from 10 up to 17 years are searched for some long-term IPW trend – self-evident climate change indicator. Results are ambiguous: for some stations or periods IPW trends are quite clear, the following years (or the other station not visible. Method of fitting linear trend to IPW series does not influence considerably the value of linear trend. The results are mostly influenced by series length, completeness and data (e.g. meteorological quality. The longer and more homogenous IPW series, the better chance to estimate the magnitude of climatologic IPW changes.

  10. ELINT Sensor Parameterization and Definition.

    Science.gov (United States)

    1985-06-19

    CPRI - PRI SAMPLE COUNT * IPW -- PULSE WIDTH SAMPLE COUNT *PRI(N) -- MEASURED PULSE INTERVAL OF NTH PULSE PW(N) -- MEASURED PULSE WIDTH OF NTH PULSE...FREQ(N) -- MEASURED FREQUENCY OF NTH PULSE - --- --- ----- -- ’ ’’ .. ......- *DECLARATIONS INTEGER K, IPP, J, I, IFR, CPRI , IPW, L,O,O I ,Q Integer

  11. Models of inter professional working for older people living at home: a survey and review of the local strategies of english health and social care statutory organisations

    Directory of Open Access Journals (Sweden)

    Goodman Claire

    2011-12-01

    Full Text Available Abstract Background Most services provided by health and social care organisations for older people living at home rely on interprofessional working (IPW. Although there is research investigating what supports and inhibits how professionals work together, less is known about how different service models deliver care to older people and how effectiveness is measured. The aim of this study was to describe how IPW for older people living at home is delivered, enacted and evaluated in England. Method An online survey of health and social care managers across England directly involved in providing services to older people, and a review of local strategies for older people services produced by primary care organisations and local government adult services organisations in England. Results The online survey achieved a 31% response rate and search strategies identified 50 local strategies that addressed IPW for older people living at home across health and social care organisations. IPW definitions varied, but there was an internal consistency of language informed by budgeting and organisation specific definitions of IPW. Community Services for Older People, Intermediate Care and Re-enablement (rehabilitation Teams were the services most frequently identified as involving IPW. Other IPW services identified were problem or disease specific and reflected issues highlighted in local strategies. There was limited agreement about what interventions or strategies supported the process of IPW. Older people and their carers were not reported to be involved in the evaluation of the services they received and it was unclear how organisations and managers judged the effectiveness of IPW, particularly for services that had an open-ended commitment to the care of older people. Conclusion Health and social care organisations and their managers recognise the value and importance of IPW. There is a theoretical literature on what supports IPW and what it can achieve

  12. FLUID AND ION SECRETION BY MALPIGHIAN TUBULES OF LARVAL CHIRONOMIDS, Chironomus riparius: EFFECTS OF REARING SALINITY, TRANSPORT INHIBITORS, AND SEROTONIN.

    Science.gov (United States)

    Zadeh-Tahmasebi, Melika; Bui, Phuong; Donini, Andrew

    2016-10-01

    Larvae of Chironomus riparius respond to ion-poor and brackish water (IPW, BW) conditions by activating ion uptake mechanisms in the anal papillae and reducing ion absorption at the rectum, respectively. The role that the Malpighian tubules play in ion and osmoregulation under these conditions is not known in this species. This study examines rates of fluid secretion and major cation composition of secreted fluid from tubules of C. riparius reared in IPW, freshwater (FW) and BW. Fluid secretion of tubules from FW and BW larvae was similar but tubules from IPW larvae secrete fluid at higher rates, are more sensitive to serotonin stimulation, and the secreted fluid contains less Na(+) . Therefore in IPW, tubules work in concert with anal papillae to eliminate excess water while conserving Na(+) in the hemolymph. Tubules do not appear to play a significant role in ion/osmoregulation under BW. Serotonin immunoreactivity in the nervous system and gastrointestinal tract of larval C. riparius was similar to that seen in mosquito larvae with the exception that the hindgut was devoid of staining. Hemolymph serotonin titer was similar in FW and IPW; hence, serotonin is not responsible for the observed high rates of fluid secretion in IPW. Instead, it is suggested that serotonin may work in a synergistic manner with an unidentified hormonal factor in IPW. Ion transport mechanisms in the tubules of C. riparius are pharmacologically similar to those of other insects.

  13. Stemcell Information: SKIP000283 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available SKIP000283 ... Diseased HPS0082 HPS0082 iPWS5 iPWS5 プラダー・ウィリー症候群 Q871 Prader Wil...patient of Prader Willi syndrome(RCB1560 PWS-Yamaguchi). del(15) was found in lymphocytes of the patient. 疾患特異的iPS細胞株。プラダー

  14. Comparison of tropospheric integrated water vapor content by using GPS, radiosonde, radiometer data and models for the tropical Island of Tahiti (French Polynesia)

    Science.gov (United States)

    Serafini, J.; Barriot, J.; Fadil, A.; Sichoix, L.

    2011-12-01

    The integrated precipitable water (IPW) in the troposphere can be subject to strong spatial and temporal variations, in particular over tropical zones. The IPW is estimated at the Geodetic Tahiti Observatory site from GPS, radiosonde, radiometer measurements. 8 years (2001-2008) of GPS observations at the IGS THTI station are processed with the GIPSY-OASIS II software package following the precise point positioning (PPP) mode. We compare the IPW of the permanent GPS data with those derived from the collocated radiometer and radiosonde data. The Global Forecast System (GFS) model which covers the entire globe with one degree latitude and longitude grid spacing, is then used to obtain the IPW at the same site. The meteorological surface data (pressure, temperature and relative humidity) also help to compute the IPW by using the Saastamoinen model. Finally, the analysis of the correlation between all these IPW estimates leads us to re-adjust the Saastamoinen parameters such that correction coefficients now better constrain the tropospheric model.

  15. Integrated Precipitable Water from GPS Observations and CIMEL Sunphotometer Measurements at CGO Belsk

    Directory of Open Access Journals (Sweden)

    Kruczyk Michał

    2017-06-01

    Full Text Available This paper describes results of integrated precipitable water co-located measurements from two techniques: GPS solution and CIMEL-318 sunphotometer. Integrated Precipitable Water (IPW is an important meteorological parameter and is derived from GPS tropospheric solutions for GPS station at Central Geophysical Observatory (CGO, Polish Academy of Sciences (PAS, Belsk and compared with sunphotometer (CIMEL-318 device by Cimel Electronique data provided by Aerosol Robotic Network (AERONET. Two dedicated and independent GPS solutions: network solution in the sub-network of European Permanent Network (EPN and precise point positioning solution have been made to obtain tropospheric delays. The quality of dedicated tropospheric solutions has been verified by comparison with EPN tropospheric combined product. Several IPW comparisons and analyses revealed systematic difference between techniques (difference RMS is over 1 mm. IPW bias changes with season: annual close to 1 mm IPW (and semi-annual term also present. IPW bias is a function of atmospheric temperature. Probable cause of this systematic deficiency in solar photometry as IPW retrieval technique is a change of optical filter characteristics in CIMEL.

  16. Integrated Precipitable Water from GPS Observations and CIMEL Sunphotometer Measurements at CGO Belsk

    Science.gov (United States)

    Kruczyk, Michał; Liwosz, Tomasz; Pietruczuk, Aleksander

    2017-06-01

    This paper describes results of integrated precipitable water co-located measurements from two techniques: GPS solution and CIMEL-318 sunphotometer. Integrated Precipitable Water (IPW) is an important meteorological parameter and is derived from GPS tropospheric solutions for GPS station at Central Geophysical Observatory (CGO), Polish Academy of Sciences (PAS), Belsk and compared with sunphotometer (CIMEL-318 device by Cimel Electronique) data provided by Aerosol Robotic Network (AERONET). Two dedicated and independent GPS solutions: network solution in the sub-network of European Permanent Network (EPN) and precise point positioning solution have been made to obtain tropospheric delays. The quality of dedicated tropospheric solutions has been verified by comparison with EPN tropospheric combined product. Several IPW comparisons and analyses revealed systematic difference between techniques (difference RMS is over 1 mm). IPW bias changes with season: annual close to 1 mm IPW (and semi-annual term also present). IPW bias is a function of atmospheric temperature. Probable cause of this systematic deficiency in solar photometry as IPW retrieval technique is a change of optical filter characteristics in CIMEL.

  17. A generalisation of classical electrodynamics for the prediction of scalar field effects

    CERN Document Server

    van Vlaenderen, K J

    2003-01-01

    Within the framework of Classical Electrodynamics (CED) it is common practice to choose freely an arbitrary gauge condition with respect to a gauge transformation of the electromagnetic potentials. The Lorenz gauge condition allows for the derivation of the inhomogeneous potential wave equations (IPWE), but this also means that scalar derivatives of the electromagnetic potentials are considered to be \\emph{unphysical}. However, these scalar expressions might have the meaning of a new physical field, $\\mathsf S$. If this is the case, then a generalised CED is required such that scalar field effects are predicted and such that experiments can be performed in order to verify or falsify this generalised CED. The IPWE are viewed as a generalised Gauss law and a generalised Ampe\\`re law, that also contain derivatives of $\\mathsf S$, after reformulating the IPWE in terms of fields. Some recent experiment show positive results that are in qualitative agreement with the presented predictions of scalar field effects, b...

  18. Assessment of a Technique for Estimating Total Column Water Vapor Using Measurements of the Infrared Sky Temperature

    Science.gov (United States)

    Merceret, Francis J.; Huddleston, Lisa L.

    2014-01-01

    A method for estimating the integrated precipitable water (IPW) content of the atmosphere using measurements of indicated infrared zenith sky temperature was validated over east-central Florida. The method uses inexpensive, commercial off the shelf, hand-held infrared thermometers (IRT). Two such IRTs were obtained from a commercial vendor, calibrated against several laboratory reference sources at KSC, and used to make IR zenith sky temperature measurements in the vicinity of KSC and Cape Canaveral Air Force Station (CCAFS). The calibration and comparison data showed that these inexpensive IRTs provided reliable, stable IR temperature measurements that were well correlated with the NOAA IPW observations.

  19. Results of the Austrian CT dose study 2010. Typical effective doses of the most frequent CT examinations; Ergebnisse der Oesterreichischen CT-Dosisstudie 2010. Effektive Dosen der haeufigsten CT-Untersuchungen und Unterschiede zwischen Anwendern

    Energy Technology Data Exchange (ETDEWEB)

    Homolka, Peter; Leithner, Robert; Billinger, Jochen [Medizinische Universitaet Wien (Austria). Zentrum fuer Medizinische Physik und Biomedizinische Technik; Gruber, Michael [Medizinische Universitaet Wien (Austria). Universitaetsklinik fuer Radiologie und Nuklearmedizin

    2014-10-01

    Purpose: To determine typical doses from common CT examinations of standard sized adult patients and their variability between CT operators for common CT indications. Materials and Methods: In a nationwide Austrian CT dose survey doses from approx. 10,000 common CT examinations of adults during 2009 and 2010 were collected and 'typical' radiation doses to the 'average patient', which turned out to have 75.6 kg body mass, calculated. Conversion coefficients from DLP to effective dose were determined and effective doses calculated according to ICRP 103. Variations of typically applied doses to the 'average patient' were expressed as ratios between 90{sup th} and 10{sup th} percentile (inter-percentile width, IPW90/10), 1st and 3{sup rd} quartile (IPW75/25), and Maximum/Minimum. Results: Median effective doses to the average patients for standard head and neck scans were 1.8 mSv (cervical spine), 1.9 mSv (brain: trauma/bleeding, stroke) to 2.2 mSv (brain: masses) with typical variation between facilities of a factor 2.5 (IPW90/10) and 1.7 (IPW75/25). In the thorax region doses were 6.4 to 6.8 mSv (pulmonary embolism, pneumonia and inflammation, oncologic scans), the variation between facilities was by a factor of 2.1 (IPW90/10) and 1.5 (IPW75/25), respectively. In the abdominal region median effective doses from 6.5 mSv (kidney stone search) to 22 mSv (liver lesions) were found (acute abdomen, staging/metastases, lumbar spine: 9-12 mSv; oncologic abdomen plus chest 16 mSv; renal tumor 20 mSv). Variation factors between facilities were on average for abdominal scans 2.7 (IPW90/10) and 1.8 (IPW75/25). Conclusion: Variations between CT operators are generally moderate for most operators, but in some indications the ratio between the minimum and the maximum of average dose to the typical standard patients exceeds a factor of 4 or even 5. Therefore, comparing average doses to Diagnostic Reference Levels (DRLs) and optimizing protocols need to

  20. GPS Estimates of Integrated Precipitable Water Aid Weather Forecasters

    Science.gov (United States)

    Moore, Angelyn W.; Gutman, Seth I.; Holub, Kirk; Bock, Yehuda; Danielson, David; Laber, Jayme; Small, Ivory

    2013-01-01

    Global Positioning System (GPS) meteorology provides enhanced density, low-latency (30-min resolution), integrated precipitable water (IPW) estimates to NOAA NWS (National Oceanic and Atmospheric Adminis tration Nat ional Weather Service) Weather Forecast Offices (WFOs) to provide improved model and satellite data verification capability and more accurate forecasts of extreme weather such as flooding. An early activity of this project was to increase the number of stations contributing to the NOAA Earth System Research Laboratory (ESRL) GPS meteorology observing network in Southern California by about 27 stations. Following this, the Los Angeles/Oxnard and San Diego WFOs began using the enhanced GPS-based IPW measurements provided by ESRL in the 2012 and 2013 monsoon seasons. Forecasters found GPS IPW to be an effective tool in evaluating model performance, and in monitoring monsoon development between weather model runs for improved flood forecasting. GPS stations are multi-purpose, and routine processing for position solutions also yields estimates of tropospheric zenith delays, which can be converted into mm-accuracy PWV (precipitable water vapor) using in situ pressure and temperature measurements, the basis for GPS meteorology. NOAA ESRL has implemented this concept with a nationwide distribution of more than 300 "GPSMet" stations providing IPW estimates at sub-hourly resolution currently used in operational weather models in the U.S.

  1. Densified GPS Estimates of Integrated Precipitable Water Vapor Improve Weather Forecasting during the North American Monsoon

    Science.gov (United States)

    Moore, A. W.; Small, I.; Gutman, S. I.; Bock, Y.; Dumas, J.; Haase, J. S.; Laber, J. L.

    2013-12-01

    Continuous GPS (CGPS) stations for observing crustal motion in the western U.S. now number more than 1200, with over 500 of them operating in real time. Tropospheric wet delay from real-time processing of the GPS data, along with co-located or nearby surface and temperature measurements, are being operationally converted to Integrated Precipitable Water Vapor (IPW) for evaluation as a forecasting tool (Gutman, 2011). The available density of real-time GPS in southern California now allows us to explore usage of densified GPS IPW in operational weather forecasting during weather conditions involving moisture extremes. Under a NASA Advanced Information Systems Technology (AIST) project, 27 southern California stations have been added to the NOAA GPS-Met observing network providing 30-minute estimates of IPW for ingestion into operational NOAA weather models, as well as for direct use by National Weather Service forecasters in monitoring developing weather conditions. The densified network proved advantageous in the 2013 North American Monsoon season, allowing forecasters to visualize rapid moisture increases at intervals between model runs and radiosonde observations and assisting in flood watch/warning decisions. We discuss the observed relationship between IPW and onset of precipitation in monsoon events in southern California and possibilities for additional decision support tools for forecasters.

  2. Inverse Probability Weighted Generalised Empirical Likelihood Estimators : Firm Size and R&D Revisited

    NARCIS (Netherlands)

    Inkmann, J.

    2005-01-01

    The inverse probability weighted Generalised Empirical Likelihood (IPW-GEL) estimator is proposed for the estimation of the parameters of a vector of possibly non-linear unconditional moment functions in the presence of conditionally independent sample selection or attrition.The estimator is applied

  3. Assessing Mediation Using Marginal Structural Models in the Presence of Confounding and Moderation

    Science.gov (United States)

    Coffman, Donna L.; Zhong, Wei

    2012-01-01

    This article presents marginal structural models with inverse propensity weighting (IPW) for assessing mediation. Generally, individuals are not randomly assigned to levels of the mediator. Therefore, confounders of the mediator and outcome may exist that limit causal inferences, a goal of mediation analysis. Either regression adjustment or IPW…

  4. POPs monitoring in Australia and New Zealand using plastic resin pellets, and International Pellet Watch as a tool for education and raising public awareness on plastic debris and POPs.

    Science.gov (United States)

    Yeo, Bee Geok; Takada, Hideshige; Taylor, Heidi; Ito, Maki; Hosoda, Junki; Allinson, Mayumi; Connell, Sharnie; Greaves, Laura; McGrath, John

    2015-12-15

    Persistent organic pollutants (i.e. PCBs, DDTs, and HCHs) were analyzed along Australia and New Zealand North Island coastlines. PCB concentrations were high in urban areas (107-294 ng/g-pellet), with Sydney Harbour the most polluted. Hepta-chlorinated PCB was abundant, with ~30% in urban areas suggesting legacy pollution. DDT concentrations showed similar pattern except in rural agricultural sites, Taupo Bay and Ahipara, New Zealand (23 and 47 ng/g-pellet). p,p'-DDE predominance at these 2 sites suggested historical input; they also had high HCH concentrations (17 and 29 ng/g-pellet). The role of International Pellet Watch (IPW) in science communication was studied through feedbacks from IPW volunteers, case studies and examples. IPW data were categorized into understandable terms and tailored reports based on volunteers' backgrounds complemented with pollution maps. The effectiveness of IPW science communication has led to its use in awareness and education activities focusing on both POPs and plastic debris issues.

  5. Propensity Score Weighting with Error-Prone Covariates

    Science.gov (United States)

    McCaffrey, Daniel F.; Lockwood, J. R.; Setodji, Claude M.

    2011-01-01

    Inverse probability weighting (IPW) estimates are widely used in applications where data are missing due to nonresponse or censoring or in observational studies of causal effects where the counterfactuals cannot be observed. This extensive literature has shown the estimators to be consistent and asymptotically normal under very general conditions,…

  6. Analyzing the Interprofessional Working of a Home-Based Primary Care Team.

    Science.gov (United States)

    Smith-Carrier, Tracy; Neysmith, Sheila

    2014-09-01

    Increasingly, interprofessional teams are responsible for providing integrated health care services. Effective teams, however, are not the result of chance but require careful planning and ongoing attention to team processes. Based on a case study involving interviews, participant observation, and a survey, we identified key attributes for effective interprofessional working (IPW) within a home-based primary care (HBPC) setting. Recognizing the importance of a theoretical model that reflects the multidimensional nature of team effectiveness research, we employed the integrated team effectiveness model to analyze our findings. The results indicated that a shared vision, common goals, respect, and trust among team members – as well as processes for ongoing communication, effective leadership, and mechanisms for conflict resolution – are vital in the development of a high-functioning IPW team. The ambiguity and uncertainty surrounding the context of service provision (clients' homes), as well the negotiation of external relationships in the HBPC field, require further investigation.

  7. Oncogenic human papillomavirus (HPV) type distribution and HPV type 16 E6 variants in two Spanish population groups with different levels of HPV infection risk.

    Science.gov (United States)

    Ortiz, M; Torres, M; Muñoz, L; Fernández-García, E; Canals, J; Cabornero, A I; Aguilar, E; Ballesteros, J; Del Amo, J; García-Sáiz, A

    2006-04-01

    The aim of this study is to determine oncogenic human papillomavirus (HPV) types and HPV type 16 (HPV16) variant distribution in two Spanish population groups, commercial sex workers and imprisoned women (CSW/IPW) and the general population. A multicenter cross-sectional study of 1,889 women from five clinical settings in two Spanish cities was conducted from May to November 2004. Oncogenic HPV infection was tested by an Hybrid Capture II (HC2) test, and positive samples were genotyped by direct sequencing using three different primer sets in L1 (MY09/11 and GP5+/GP6+) and E6/E7. HPV16 variants were identified by sequencing the E6, E2, and L1 regions. Four hundred twenty-five samples were positive for the HC2 test, 31.5% from CSW/IPW and 10.7% from the general population. HPV16 was the most frequent type. Distinct profiles of oncogenic HPV type prevalence were observed across the two populations. In order of decreasing frequency, HPV types 16, 31, 58, 66, 56, and 18 were most frequent in CSW/IPW women, and types 16, 31, 52, 68, 51, and 53 were most frequent in the general population. We analyzed HPV16 intratype variants, and a large majority (78.7%) belonged to the European lineage. AA variants were detected in 16.0% of cases. African variants belonging to classes Af1 (4.0%) and Af2 (1.3%) were detected. Different HPV types and HPV16 intratype variants are involved in oncogenic HPV infections in our population. These results suggest that HPV type distribution differs in CSW/IPW women and in the general population, although further analysis is necessary.

  8. Polycyclic Aromatic Hydrocarbons (PAHs) and Hopanes in Plastic Resin Pellets as Markers of Oil Pollution via International Pellet Watch Monitoring.

    Science.gov (United States)

    Yeo, Bee Geok; Takada, Hideshige; Hosoda, Junki; Kondo, Atsuko; Yamashita, Rei; Saha, Mahua; Maes, Thomas

    2017-08-01

    Oil pollution in the marine environment is an unavoidable problem due to chronic input from local sources, particularly in urban areas and oil spills. Oil pollution not only causes immediate physical damages to surrounding wildlife but also some components, including higher molecular weight PAHs, can persist in the environment for many years and pose insidious threats to the ecosystem. Long-term and nontargeted monitoring of oil pollution is important. This paper examines the ability of International Pellet Watch (IPW) for initial identification and monitoring of oil pollution by analysing PAHs and hopanes in plastic pellet samples collected globally by volunteers. PAH concentrations with the sum of 28 parent and methyl PAHs vary geographically, ranging from 0.035 to 24.4 µg/g-pellet, in line with the presence or absence of local oil pollution sources, such as oil refineries or oil spill sites. This suggests that PAHs can be used to monitor petroleum pollution in IPW. A colour-coded categorization for PAH concentrations within IPW monitoring also is established to facilitate data presentation and understanding. PAH concentrations are generally higher in Western Europe, especially around the North Sea shorelines, moderate in East Asia and North America, and lower in South East Asia, Oceania, South America, and Africa. Hopane concentrations, with a smaller spatial variation (1.7-101 µg/g-pellet), showed no spatial pattern. This result and the poor correlation between hopanes and PAHs suggest that hopane concentrations alone are unsuited to identify petroleum pollution. However, hopane compositions can be used for fingerprinting sources of oil pollution. Thus, both PAHs and hopanes in IPW allow for low cost, remote monitoring of global oil pollution.

  9. Involvement of endogenous prostaglandins in ischemic preconditioning in pigs.

    Science.gov (United States)

    Gres, Petra; Schulz, Rainer; Jansen, Johanna; Umschlag, Christian; Heusch, Gerd

    2002-08-15

    In pigs, the infarct size (IS) reduction achieved by a strong preconditioning stimulus (IPs) of 10 min ischemia and 15 min reperfusion is greater than that by a weaker preconditioning stimulus (IPw) of 3 min ischemia and 15 min reperfusion. The cardioprotection achieved by IPw is completely abolished by blockade of bradykinin-B(2)-receptors. Since activation of bradykinin-B(2)-receptors subsequently activates cyclooxygenase, we now tested whether or not inhibition of cyclooxygenase with indomethacin interferes with IS reduction by IP. In 42 enflurane-anesthetized pigs, the LAD coronary artery was cannulated, and subendocardial blood flow (ENDO, microspheres, ml/min/g) and IS (%, TTC-staining) were determined. Following 90 min ischemia and 120 min reperfusion, IS averaged 25.5+/-3.8 (S.E.M.) (ENDO: 0.05+/-0.01). IS was reduced by IPw to 6.3+/-2.1 (ENDO: 0.07+/-0.01) and further reduced by IPs to 2.4+/-1.0 (ENDO: 0.06+/-0.01). Indomethacin (10 mg/kg i.v.) did not alter IS per se (20.9+/-5.4, ENDO: 0.06+/-0.02), but completely abolished the IS reduction by IPw (23.2+/-5.9, ENDO: 0.06+/-0.01). In contrast, indomethacin abolished the IS reduction by IPs in only two of seven pigs (16.1+/-7.4, ENDO: 0.05+/-0.01). Prostaglandins are involved in IP. However, with stronger IP stimuli other triggers/mediators can compensate for the lack of prostaglandins.

  10. Inverse Probability Weighted Generalised Empirical Likelihood Estimators : Firm Size and R&D Revisited

    OpenAIRE

    2005-01-01

    The inverse probability weighted Generalised Empirical Likelihood (IPW-GEL) estimator is proposed for the estimation of the parameters of a vector of possibly non-linear unconditional moment functions in the presence of conditionally independent sample selection or attrition.The estimator is applied to the estimation of the firm size elasticity of product and process R&D expenditures using a panel of German manufacturing firms, which is affected by attrition and selection into R&D activities....

  11. Estimating the treatment effect from non-randomized studies: The example of reduced intensity conditioning allogeneic stem cell transplantation in hematological diseases

    Directory of Open Access Journals (Sweden)

    Resche-Rigon Matthieu

    2012-08-01

    Full Text Available Abstract Background In some clinical situations, for which RCT are rare or impossible, the majority of the evidence comes from observational studies, but standard estimations could be biased because they ignore covariates that confound treatment decisions and outcomes. Methods Three observational studies were conducted to assess the benefit of Allo-SCT in hematological malignancies of multiple myeloma, follicular lymphoma and Hodgkin’s disease. Two statistical analyses were performed: the propensity score (PS matching approach and the inverse probability weighting (IPW approach. Results Based on PS-matched samples, a survival benefit in MM patients treated by Allo-SCT, as compared to similar non-allo treated patients, was observed with an HR of death at 0.35 (95%CI: 0.14-0.88. Similar results were observed in HD, 0.23 (0.07-0.80 but not in FL, 1.28 (0.43-3.77. Estimated benefits of Allo-SCT for the original population using IPW were erased in HR for death at 0.72 (0.37-1.39 for MM patients, 0.60 (0.19-1.89 for HD patients, and 2.02 (0.88-4.66 for FL patients. Conclusion Differences in estimated benefits rely on whether the underlying population to which they apply is an ideal randomized experimental population (PS or the original population (IPW. These useful methods should be employed when assessing the effects of innovative treatment in non-randomized experiments.

  12. Wastewater quality monitoring system using sensor fusion and machine learning techniques.

    Science.gov (United States)

    Qin, Xusong; Gao, Furong; Chen, Guohua

    2012-03-15

    A multi-sensor water quality monitoring system incorporating an UV/Vis spectrometer and a turbidimeter was used to monitor the Chemical Oxygen Demand (COD), Total Suspended Solids (TSS) and Oil & Grease (O&G) concentrations of the effluents from the Chinese restaurant on campus and an electrocoagulation-electroflotation (EC-EF) pilot plant. In order to handle the noise and information unbalance in the fused UV/Vis spectra and turbidity measurements during the calibration model building, an improved boosting method, Boosting-Iterative Predictor Weighting-Partial Least Squares (Boosting-IPW-PLS), was developed in the present study. The Boosting-IPW-PLS method incorporates IPW into boosting scheme to suppress the quality-irrelevant variables by assigning small weights, and builds up the models for the wastewater quality predictions based on the weighted variables. The monitoring system was tested in the field with satisfactory results, underlying the potential of this technique for the online monitoring of water quality. Copyright © 2011 Elsevier Ltd. All rights reserved.

  13. Kernel machine testing for risk prediction with stratified case cohort studies.

    Science.gov (United States)

    Payne, Rebecca; Neykov, Matey; Jensen, Majken Karoline; Cai, Tianxi

    2016-06-01

    Large assembled cohorts with banked biospecimens offer valuable opportunities to identify novel markers for risk prediction. When the outcome of interest is rare, an effective strategy to conserve limited biological resources while maintaining reasonable statistical power is the case cohort (CCH) sampling design, in which expensive markers are measured on a subset of cases and controls. However, the CCH design introduces significant analytical complexity due to outcome-dependent, finite-population sampling. Current methods for analyzing CCH studies focus primarily on the estimation of simple survival models with linear effects; testing and estimation procedures that can efficiently capture complex non-linear marker effects for CCH data remain elusive. In this article, we propose inverse probability weighted (IPW) variance component type tests for identifying important marker sets through a Cox proportional hazards kernel machine (CoxKM) regression framework previously considered for full cohort studies (Cai et al., 2011). The optimal choice of kernel, while vitally important to attain high power, is typically unknown for a given dataset. Thus, we also develop robust testing procedures that adaptively combine information from multiple kernels. The proposed IPW test statistics have complex null distributions that cannot easily be approximated explicitly. Furthermore, due to the correlation induced by CCH sampling, standard resampling methods such as the bootstrap fail to approximate the distribution correctly. We, therefore, propose a novel perturbation resampling scheme that can effectively recover the induced correlation structure. Results from extensive simulation studies suggest that the proposed IPW CoxKM testing procedures work well in finite samples. The proposed methods are further illustrated by application to a Danish CCH study of Apolipoprotein C-III markers on the risk of coronary heart disease. © 2015, The International Biometric Society.

  14. New York City International Polar Weekend at the American Museum of Natural History

    Science.gov (United States)

    Pfirman, S.; Turrin, M.; Macphee, R.

    2008-12-01

    The American Museum of Natural History, in partnership with Lamont-Doherty Earth Observatory and the Earth Institute of Columbia University and Barnard College, is featuring the International Polar Year through a New York City International Polar Weekend (NYC-IPW) in 2007, 2008 and 2009. The event showcases current polar research, polar environmental changes, history and culture during two days of family programs and activities, performances, and lectures. The goal of the NYC-IPW is to engage diverse audiences and enhance the public understanding of polar science, in particular IPY research, through close interactions with polar experts. Activities for the public include many disciplines, ranging from the physical sciences and cultural anthropology to music and art, and are presented in many forms, from lectures, panels and films to posters and play. Highlights of the NYC-IPW include: 1) A polar fair for youth and adults, showcasing scientists, artists, and educators who have worked at one or both poles and including many interactive exhibits featuring such topics as life in New York at the end of the last Ice Age, how Arctic sea ice is changing, and life on and under the ice. 2) Performances and presentations oriented towards children and families, including Inuit Throat Singers, Central Park Zoo Theater Group, and a northern lights show. 3) Lectures showcasing current IPY research and addressing such issues as the possible effects of climate change on the poles and the rest of the world, as well as polar poetry, art and film. 4) A partnership with New York City Urban Advantage program for Middle School students in the city to meet with scientists, teachers and students who had participated in polar research and travel. 5) Norwegian Consulate sponsorship of science presenters and Sami performers. The March 2007 event involved 85 presenters and volunteers from 22 institutions, and attracted ca. 3,500 visitors. Approximately 5,000 visitors attended the February 2008

  15. The liquorice root derivative glycyrrhetinic acid can ameliorate ionoregulatory disturbance in rainbow trout (Oncorhynchus mykiss) abruptly exposed to ion-poor water.

    Science.gov (United States)

    Chen, Chun Chih; Kolosov, Dennis; Kelly, Scott P

    2016-09-01

    To consider the idea that a dietary botanical supplement could act as an adaptogen in a teleost fish, the effect of a liquorice root derivative (18β-glycyrrhetinic acid, 18βGA) on rainbow trout following an acute ionoregulatory stressor was examined. Freshwater (FW) trout were fed a control or 18βGA supplemented diet (0, 5, or 50μg 18βGA/g diet) for 2weeks, then abruptly exposed to ion-poor water (IPW) for 24h. Following IPW exposure, muscle moisture content and serum cortisol levels elevated and serum [Na(+)] and/or [Cl(-)] reduced in control and 50μg/g 18βGA-fed fish. However, these endpoints were unaltered in 5μg/g 18βGA-fed fish. Gill tissue was investigated for potential mechanisms of 18βGA action by examining mRNA abundance of genes encoding corticosteroid receptors (CRs), 11β-hydroxysteroid dehydrogenase 2 (11β-hsd2), and tight junction (TJ) proteins, as well as Na(+)-K(+)-ATPase and H(+)-ATPase activity, and mitochondrion-rich cell (MRC) morphometrics. Following IPW exposure, CR and 11β-hsd2 mRNA, MRC fractional surface, Na(+)-K(+)-ATPase and H(+)-ATPase activity were unaltered or decreased in 50μg 18βGA fish, as was mRNA encoding select TJ proteins. In contrast, 5μg 18βGA-fed fish exhibited elevated 11β-hsd2 and CR mRNA abundance versus 50μg 18βGA-fed, and reduced MRC apical area as well as some differences in TJ protein mRNA abundance versus control fish. Data suggest that 18βGA, at low levels, may be adaptogenic in trout and might help to ameliorate ionoregulatory perturbation following IPW exposure. This seems to occur, in part, through 18βGA-induced alterations in the biochemistry and physiology of the gill.

  16. Airborne Measurements of European Sky and Terrain Radiances.

    Science.gov (United States)

    1981-08-01

    su Me (rim) Into PmbllW W[,ml#w) AwW C~mn Wm Ipw m) Tfuwt 0. 4 478 199 5.14EPE03 31VE+0E 4.07E+07 4,H4E+0S S 01 I "a0 664 30 2 1 57E +03 2 30E+07 I 75E...altitudes, A-292M end 1-1175de. 9 TAkl 4.1. (CoAN) Summary orsk ad Tupima ainu m SrM r ir 2 Aveibbl Rodia.VitaFILT NO DATE S dEoigt Al itudse (mnAU

  17. Modeling of tropospheric integrated water vapor content using GPS, radiosonde, radiometer, rain gauge, and surface meteorological data in a tropical region (French Polynesia)

    Science.gov (United States)

    Serafini, Jonathan; Barriot, Jean-Pierre; Hopuare, Marania; Sichoix, Lydie; Fadil, Abdelali

    2012-11-01

    The integrated precipitable water vapor (IPW) is characterized by strong spatial and temporal variability, especially over tropical regions where the troposhere is not purely in hydrostatic equilibrium (convection). As an evidence, the survey of water vapor distibution as permanently as possible is an important issue and should serve as inputs for tropical climate modelling. In this paper, we present an estimation of the IPV from ground­ ba,.sed GPS receivers, which we compare to radiosondes and microwave radiometer. The data used here were collected in the vicinity of French Polynesia University site, during eight years from 2001 to 2008. In addition, we also include the IPW calculated using Era-Interim reanalyses (ECMWF). The main purpose of this paper is to highlight precision, qualities and limitations of each method available on the Island of Tahiti. During wet periods, the radiosondes vertical profiles of water vapor show an efficient mixing of water vapor between the the boundary layer (below trade winds inversion at Tahiti) and the free troposphere. Thus the rainy event detection allows to better constrain the validity range of a model of the vertical distribution of water vapor, which is based on a pseudo-adiabatic saturated evolution of the temperature.

  18. Crowd sourcing a new paradigm for interactome driven drug target identification in Mycobacterium tuberculosis.

    Science.gov (United States)

    Vashisht, Rohit; Mondal, Anupam Kumar; Jain, Akanksha; Shah, Anup; Vishnoi, Priti; Priyadarshini, Priyanka; Bhattacharyya, Kausik; Rohira, Harsha; Bhat, Ashwini G; Passi, Anurag; Mukherjee, Keya; Choudhary, Kumari Sonal; Kumar, Vikas; Arora, Anshula; Munusamy, Prabhakaran; Subramanian, Ahalyaa; Venkatachalam, Aparna; Gayathri, S; Raj, Sweety; Chitra, Vijaya; Verma, Kaveri; Zaheer, Salman; Balaganesh, J; Gurusamy, Malarvizhi; Razeeth, Mohammed; Raja, Ilamathi; Thandapani, Madhumohan; Mevada, Vishal; Soni, Raviraj; Rana, Shruti; Ramanna, Girish Muthagadhalli; Raghavan, Swetha; Subramanya, Sunil N; Kholia, Trupti; Patel, Rajesh; Bhavnani, Varsha; Chiranjeevi, Lakavath; Sengupta, Soumi; Singh, Pankaj Kumar; Atray, Naresh; Gandhi, Swati; Avasthi, Tiruvayipati Suma; Nisthar, Shefin; Anurag, Meenakshi; Sharma, Pratibha; Hasija, Yasha; Dash, Debasis; Sharma, Arun; Scaria, Vinod; Thomas, Zakir; Chandra, Nagasuma; Brahmachari, Samir K; Bhardwaj, Anshu

    2012-01-01

    A decade since the availability of Mycobacterium tuberculosis (Mtb) genome sequence, no promising drug has seen the light of the day. This not only indicates the challenges in discovering new drugs but also suggests a gap in our current understanding of Mtb biology. We attempt to bridge this gap by carrying out extensive re-annotation and constructing a systems level protein interaction map of Mtb with an objective of finding novel drug target candidates. Towards this, we synergized crowd sourcing and social networking methods through an initiative 'Connect to Decode' (C2D) to generate the first and largest manually curated interactome of Mtb termed 'interactome pathway' (IPW), encompassing a total of 1434 proteins connected through 2575 functional relationships. Interactions leading to gene regulation, signal transduction, metabolism, structural complex formation have been catalogued. In the process, we have functionally annotated 87% of the Mtb genome in context of gene products. We further combine IPW with STRING based network to report central proteins, which may be assessed as potential drug targets for development of drugs with least possible side effects. The fact that five of the 17 predicted drug targets are already experimentally validated either genetically or biochemically lends credence to our unique approach.

  19. Crowd sourcing a new paradigm for interactome driven drug target identification in Mycobacterium tuberculosis.

    Directory of Open Access Journals (Sweden)

    Rohit Vashisht

    Full Text Available A decade since the availability of Mycobacterium tuberculosis (Mtb genome sequence, no promising drug has seen the light of the day. This not only indicates the challenges in discovering new drugs but also suggests a gap in our current understanding of Mtb biology. We attempt to bridge this gap by carrying out extensive re-annotation and constructing a systems level protein interaction map of Mtb with an objective of finding novel drug target candidates. Towards this, we synergized crowd sourcing and social networking methods through an initiative 'Connect to Decode' (C2D to generate the first and largest manually curated interactome of Mtb termed 'interactome pathway' (IPW, encompassing a total of 1434 proteins connected through 2575 functional relationships. Interactions leading to gene regulation, signal transduction, metabolism, structural complex formation have been catalogued. In the process, we have functionally annotated 87% of the Mtb genome in context of gene products. We further combine IPW with STRING based network to report central proteins, which may be assessed as potential drug targets for development of drugs with least possible side effects. The fact that five of the 17 predicted drug targets are already experimentally validated either genetically or biochemically lends credence to our unique approach.

  20. Mark-specific hazard ratio model with missing multivariate marks.

    Science.gov (United States)

    Juraska, Michal; Gilbert, Peter B

    2016-10-01

    An objective of randomized placebo-controlled preventive HIV vaccine efficacy (VE) trials is to assess the relationship between vaccine effects to prevent HIV acquisition and continuous genetic distances of the exposing HIVs to multiple HIV strains represented in the vaccine. The set of genetic distances, only observed in failures, is collectively termed the 'mark.' The objective has motivated a recent study of a multivariate mark-specific hazard ratio model in the competing risks failure time analysis framework. Marks of interest, however, are commonly subject to substantial missingness, largely due to rapid post-acquisition viral evolution. In this article, we investigate the mark-specific hazard ratio model with missing multivariate marks and develop two inferential procedures based on (i) inverse probability weighting (IPW) of the complete cases, and (ii) augmentation of the IPW estimating functions by leveraging auxiliary data predictive of the mark. Asymptotic properties and finite-sample performance of the inferential procedures are presented. This research also provides general inferential methods for semiparametric density ratio/biased sampling models with missing data. We apply the developed procedures to data from the HVTN 502 'Step' HIV VE trial.

  1. Future agriculture with minimized phosphorus losses to waters: Research needs and direction.

    Science.gov (United States)

    Sharpley, Andrew N; Bergström, Lars; Aronsson, Helena; Bechmann, Marianne; Bolster, Carl H; Börling, Katarina; Djodjic, Faruk; Jarvie, Helen P; Schoumans, Oscar F; Stamm, Christian; Tonderski, Karin S; Ulén, Barbro; Uusitalo, Risto; Withers, Paul J A

    2015-03-01

    The series of papers in this issue of AMBIO represent technical presentations made at the 7th International Phosphorus Workshop (IPW7), held in September, 2013 in Uppsala, Sweden. At that meeting, the 150 delegates were involved in round table discussions on major, predetermined themes facing the management of agricultural phosphorus (P) for optimum production goals with minimal water quality impairment. The six themes were (1) P management in a changing world; (2) transport pathways of P from soil to water; (3) monitoring, modeling, and communication; (4) importance of manure and agricultural production systems for P management; (5) identification of appropriate mitigation measures for reduction of P loss; and (6) implementation of mitigation strategies to reduce P loss. This paper details the major challenges and research needs that were identified for each theme and identifies a future roadmap for catchment management that cost-effectively minimizes P loss from agricultural activities.

  2. Spectroscopic Classification of AT2016cvw as a normal Type Ia Supernova

    Science.gov (United States)

    Leonard, D. C.; Sheehan, P.; McCarthy, D.; Follette, K.; Moustakas, J.; Alaniz, M.; Beaumont, C.; Batterman, T.; Black, E.; Bowers, T.; Cryder, M.; Davis, C.; Dawsey, R.; Douglas, E.; Gordon, S.; Gramze, S.; Greiner, M.; Hart, K.; Holt, A.; Hu, J.; Ingebretsen, C.; Iyer, D.; Josephson, R.; Kapko, A.; Keane, J.; Kimberlin, T.; Kinman, S.; Klusmeyer, J.; Kolderup, E.; Kresina, K.; Madden, M.; Meiman, E.; Miniconi, S.; Morton, A.; Neumann, K.; Noguerra, T.; Regester, B.; Regester, J.; Rosenthal, M.; Schlingman, A.; Schlingman, W.; Schlingman, W.; Smith, A.; Svoboda, B.; Watson, L.; Whitesell, R.

    2016-06-01

    We report spectroscopic classification of AT2016cvw (also known as PTSS-16ipw), discovered 2016 June 18.813 UT by the PMO-Tsinghua Supernova Survey (PTSS) in MCG +02-58-008 (z=0.038877; Huchra et al. 2012, ApJS, 199, 26, via NED), through inspection of an optical spectrum (range 370-690 nm, resolution 0.8 nm) obtained with the 2.3-m Bok telescope (+ Boller & Chivens spectrograph) at Kitt Peak on 2016 June 20.423 UT. Cross-correlation with a library of supernova spectra using the "Supernova Identification" code (SNID; Blondin and Tonry 2007, ApJ, 666, 1024) and GELATO (Harutyunyan et al. 2008, A & A, 488, 383) finds convincing spectral matches with a number of normal Type-Ia supernovae roughly 3 days before maximum light.

  3. Monitoring of substrate and product concentrations in acetic fermentation processes for onion vinegar production by NIR spectroscopy: value addition to worthless onions.

    Science.gov (United States)

    González-Sáiz, J M; Esteban-Díez, I; Sánchez-Gallardo, C; Pizarro, C

    2008-08-01

    Wastes and by-products of the onion-processing industry pose an increasing disposal and environmental problem and represent a loss of valuable sources of nutrients. The present study focused on the production of vinegar from worthless onions as a potential valorisation route which could provide a viable solution to multiple disposal and environmental problems, simultaneously offering the possibility of converting waste materials into a useful food-grade product and of exploiting the unique properties and health benefits of onions. This study deals specifically with the second and definitive step of the onion vinegar production process: the efficient production of vinegar from onion waste by transforming onion ethanol, previously produced by alcoholic fermentation, into acetic acid via acetic fermentation. Near-infrared spectroscopy (NIRS), coupled with multivariate calibration methods, has been used to monitor the concentrations of both substrates and products in acetic fermentation. Separate partial least squares (PLS) regression models, correlating NIR spectral data of fermentation samples with each kinetic parameter studied, were developed. Wavelength selection was also performed applying the iterative predictor weighting-PLS (IPW-PLS) method in order to only consider significant spectral features in each model development to improve the quality of the final models constructed. Biomass, substrate (ethanol) and product (acetic acid) concentration were predicted in the acetic fermentation of onion alcohol with high accuracy using IPW-PLS models with a root-mean-square error of the residuals in external prediction (RMSEP) lower than 2.5% for both ethanol and acetic acid, and an RMSEP of 6.1% for total biomass concentration (a very satisfactory result considering the relatively low precision and accuracy associated with the reference method used for determining the latter). Thus, the simple and reliable calibration models proposed in this study suggest that they

  4. The human NTT gene: Identification of a novel 17-kb noncoding nuclear RNA expressed in activated CD4{sup +} T cells

    Energy Technology Data Exchange (ETDEWEB)

    Liu, A.Y.; Torchia, B.S.; Migeon, B.R. [Johns Hopkins Univ. School of Medicine, Baltimore, MD (United States)] [and others

    1997-01-15

    We describe the cloning and characterization of the NTT gene (noncoding transcript in T cells), identified by differential display RT-PCR based on the differential presence of its transcript in a subset of activated, human CD4{sup +} T-cell clones. The full-length cDNA and genomic sequences were cloned and found to produce a 17-kb transcript that is polyadenylated, but is not spliced. Consistent with the transcript`s nuclear predominance, NTT has no open reading frame larger than 270 bp. It is transcribed in a select subset of CD4{sup +} T-cell clones propagated in vitro. Its transcription can also be induced in freshly isolated T cells by in vitro activation with PHA or with PMA and ionomycin. In vivo, NTT transcripts are found only in activated, but not resting, T cells. Transcripts were absent in a variety of lymphoid cell lines and transformed lines from other tissues. NTT is a new member of the small group of genes including XIST (X{sub i}-specific transcript), H19, and IPW (imprinted gene in the Prader-Willi syndrome region), which are transcribed but not translated, and may have a role in the regulation of neighboring genes. XIST, H19, and IPW exhibit monoallelic expression, but both NTT alleles are expressed in CD4{sup +} T-cell clones. Southern blot and fluorescence in situ hybridization analyses show that NTT is a single-copy gene residing in chromosome 6q23-q24, near the interferon-{gamma} receptor gene (IFN-{gamma}R). Their proximity and shared expression pattern suggest a possible functional relationship. 57 refs., 10 figs., 1 tab.

  5. Early cannabis initiation and educational attainment: is the association causal? Data from the French TEMPO study.

    Science.gov (United States)

    Melchior, Maria; Bolze, Camille; Fombonne, Eric; Surkan, Pamela J; Pryor, Laura; Jauffret-Roustide, Marie

    2017-05-18

    : Adolescent cannabis use has been reported to predict later educational attainment; however, results of past studies may be confounded by inappropriate control for factors that make some youths more likely to use cannabis precociously than others. We aimed to test the possibility of a causal relationship between early cannabis initiation and later academic achievement. : Analyses are based on data collected among TEMPO cohort study participants (France, 2009, n  = 1103, 22-35 years). Participants were previously assessed in childhood (1991) and adolescence (1999); additionally, their parents had taken part in a longitudinal epidemiological cohort study (GAZEL). Early cannabis initiation was defined as use at age 16 or earlier. Educational attainment was defined as the completion of a high-school degree ('Baccalauréat'). Early (up to and including age 16 years) and late (after age 16 years) cannabis-use initiators were compared with non-users using logistic regression models controlled for inverse probability weights (IPWs) of exposure calculated based on participants' socio-demographic, juvenile and parental characteristics. : In age- and sex-adjusted analyses, early cannabis initiators were more likely than non-users to have low educational attainment [odds ratio (OR): 1.77, 95% confidence interval (CI) 1.22-2.55]. In IPWs-controlled analyses, this association somewhat decreased (OR: 1.64, 95% CI 1.13-2.40). Late cannabis initiators did not have lower educational attainment than non-users. Early cannabis use and educational attainment appeared more strongly associated in young women than in young men. : Early cannabis can cause low educational attainment. Youths who initiate cannabis use early require attention from addiction and education specialists to reduce their odds of poor long-term outcomes.

  6. Evaluating Propensity Score Methods in a Quasi-Experimental Study of the Impact of Menu-Labeling.

    Directory of Open Access Journals (Sweden)

    Stephanie L Mayne

    Full Text Available Quasi-experimental studies of menu labeling have found mixed results for improving diet. Differences between experimental groups can hinder interpretation. Propensity scores are an increasingly common method to improve covariate balance, but multiple methods exist and the improvements associated with each method have rarely been compared. In this re-analysis of the impact of menu labeling, we compare multiple propensity score methods to determine which methods optimize balance between experimental groups.Study participants included adult customers who visited full-service restaurants with menu labeling (treatment and without (control. We compared the balance between treatment groups obtained by four propensity score methods: 1 1:1 nearest neighbor matching (NN, 2 augmented 1:1 NN (using caliper of 0.2 and an exact match on an imbalanced covariate, 3 full matching, and 4 inverse probability weighting (IPW. We then evaluated the treatment effect on differences in nutrients purchased across the different methods.1:1 NN resulted in worse balance than the original unmatched sample (average standardized absolute mean distance [ASAM]: 0.185 compared to 0.171. Augmented 1:1 NN improved balance (ASAM: 0.038 but resulted in a large reduction in sample size. Full matching and IPW improved balance over the unmatched sample without a reduction in sample size (ASAM: 0.049 and 0.031, respectively. Menu labeling was associated with decreased calories, fat, sodium and carbohydrates in the unmatched analysis. Results were qualitatively similar in the propensity score matched/weighted models.While propensity scores offer an increasingly popular tool to improve causal inference, choosing the correct method can be challenging. Our results emphasize the benefit of examining multiple methods to ensure results are consistent, and considering approaches beyond the most popular method of 1:1 NN matching.

  7. A role for tight junction-associated MARVEL proteins in larval sea lamprey (Petromyzon marinus) osmoregulation.

    Science.gov (United States)

    Kolosov, Dennis; Bui, Phuong; Donini, Andrew; Wilkie, Mike P; Kelly, Scott P

    2017-08-10

    This study reports on tight junction-associated MARVEL proteins of larval sea lamprey (Petromyzon marinus) and their potential role in ammocoete osmoregulation. Two Occludin isoforms (designated Ocln and Ocln-a) and a tricellulin (Tric) were identified. Transcripts encoding ocln, ocln-a, and tric were broadly expressed in larval lamprey, with greatest abundance of ocln in gut, liver and kidney, ocln-a in the gill and skin, and tric in the kidney. Ocln and Ocln-a resolved as ∼63 kDa and ∼35 kDa MW proteins respectively while Tric resolved as a ∼50 kDa protein. Ocln immunolocalized to the gill vasculature and in gill mucous cells while Ocln-a localized to the gill pouch and gill epithelium. Both Ocln and Ocln-a localized in the nephron, the epidermis and the luminal side of the gut. In branchial tissue, Tric exhibited punctate localization, consistent with its presence at regions of tricellular contact. Following ion-poor water (IPW) acclimation of ammocoetes, serum [Na(+)] and [Cl(-)] reduced, but not [Ca(++)], and carcass moisture content increased. In association, Ocln abundance increased in skin and kidney, but reduced in gill of IPW-acclimated ammocoetes while Ocln-a abundance reduced in the kidney only. Tric abundance increased in the gill. Region-specific alterations in ocln, ocln-a and tric mRNA abundance was also observed in the gut. Data support a role for Ocln, Ocln-a and Tric in the osmoregulatory strategies of a basal vertebrate. © 2017. Published by The Company of Biologists Ltd.

  8. Food and water security scenarios for East Africa over next 20 years

    Science.gov (United States)

    Shukla, S.; Funk, C. C.; Verdin, J. P.; Peters-Lidard, C. D.

    2013-12-01

    of the Indo-Pacific warming signal (IPWS). These modes are used in conjunction with CMIP5-estimates of IPWS to project 2030 climate conditions. In the second approach we use the much simpler Composite Delta Method to generate climate projections. Future climate projections are generated by simply altering the mean observed climate to match the mean climate of the climate model projections. Projections of precipitation and temperature from both approaches were then used to drive NASA's FEWS NET Land Data Assimilation System (FLDAS) to simulate the hydrologic variables most relevant to agriculture and water security: runoff, soil moisture and evapotranspiration. These outputs inform 2030 food and water security scenarios for East Africa. Finally we also investigate the impact of precipitation versus temperature changes on agriculture and water security in East Africa. We do so by keeping either one of those forcings constant while using the actual projections of the other variable to generate projections of hydrologic variables as described above.

  9. Cluster adjusted regression for displaced subject data (CARDS): Marginal inference under potentially informative temporal cluster size profiles.

    Science.gov (United States)

    Bible, Joe; Beck, James D; Datta, Somnath

    2016-06-01

    Ignorance of the mechanisms responsible for the availability of information presents an unusual problem for analysts. It is often the case that the availability of information is dependent on the outcome. In the analysis of cluster data we say that a condition for informative cluster size (ICS) exists when the inference drawn from analysis of hypothetical balanced data varies from that of inference drawn on observed data. Much work has been done in order to address the analysis of clustered data with informative cluster size; examples include Inverse Probability Weighting (IPW), Cluster Weighted Generalized Estimating Equations (CWGEE), and Doubly Weighted Generalized Estimating Equations (DWGEE). When cluster size changes with time, i.e., the data set possess temporally varying cluster sizes (TVCS), these methods may produce biased inference for the underlying marginal distribution of interest. We propose a new marginalization that may be appropriate for addressing clustered longitudinal data with TVCS. The principal motivation for our present work is to analyze the periodontal data collected by Beck et al. (1997, Journal of Periodontal Research 6, 497-505). Longitudinal periodontal data often exhibits both ICS and TVCS as the number of teeth possessed by participants at the onset of study is not constant and teeth as well as individuals may be displaced throughout the study.

  10. [Cooperation of medical and pharmaceutical sciences between private and national universities to educate professionals in the fields of drug development and rational pharmacotherapy].

    Science.gov (United States)

    Iwakawa, Seigo

    2012-01-01

    Cooperation in education and research in medical and pharmaceutical sciences between Kobe Pharmaceutical University and Kobe University was started in 2008 for training professionals in drug development and rational pharmacotherapy. Initially, we started a two-year pharmacy residency program. Our pharmacy residents can attend lectures at our universities, and they also help pharmacist preceptors educate undergraduate pharmacy students in practical training. As curricula for cooperative education of pharmacy, nursing and medical students, we developed two new elective subjects (early exposure to clinical training for first year students and IPW (inter-professional work) seminar for fifth year pharmacy students) to learn about the roles of health care professionals in a medical team. Cooperative research between faculty members and graduate students is also in progress. For faculty and staff developments, invited lectures by clinical pharmacy and medical professors from the United States on the clinical education system in pharmacy and medicine in the United States have been held. This systematic cooperation will contribute to the promotion of a new curriculum for inter-professional education in the health-science fields.

  11. Rapid Retrieval and Assimilation of Ground Based GPS-Met Observations at the NOAA Forecast Systems Laboratory: Impact on Weather Forecasts

    Science.gov (United States)

    Gutman, S.

    2003-04-01

    This year, 2003, marks the tenth anniversary of ground-based Global Positioning System meteorology. GPS-Met as we now know it started in 1992 with the definition of the essential techniques to retrieve integrated (total column) precipitable water vapor (IPW) from zenith-scaled neutral atmospheric signal delays (Bevis et al., 1992). It culminated with the GPS/Storm experiment in 1993, which demonstrated the ability to make IPW measurements with about the predicted accuracy under warm-weather conditions (Rocken et al., 1995). Since then, most of the major advances in GPS-Met data processing have been in the form of improved mapping functions (Niell, 1996), the estimation of GPS signal delays in an absolute (Duan et al., 1996) versus a relative sense (Rocken et al., 1993), and improved GPS satellite orbit accuracy with reduced latency (Fang et al., 1998). Experiments with other GPS-Met data processing techniques, such as the estimation of line-of-sight GPS signal delays using a double-difference to zero-difference technique described by Alber et al. (2000) and Braun et al. (2001) are noted, but lingering questions about the validity of this approach (Gutman, 2002), and not the potential value of a slant-path measurements per se, (as enumerated by MacDonald and Xie, 2001 or Ha et al., 2002) have thus far precluded its routine implementation at the National Oceanic and Atmospheric Administration Forecast Systems Laboratory (NOAA/FSL). Since 1994, NOAA/FSL has concentrated on evaluating the scientific and engineering bases of ground-based GPS-Met and assessing its utility for operational weather forecasting, climate monitoring, satellite calibration and validation, and improved differential GPS positioning and navigation. The term “rapid” in the title of this paper is defined as “available in time to be used for a specific application.” The requirement for high accuracy GPS-Met retrievals with lower latency is primarily driven by two factors: the trend toward

  12. Variable allelic expression of imprinted genes in human pluripotent stem cells during differentiation into specialized cell types in vitro.

    Science.gov (United States)

    Park, Sang-Wook; Kim, Jihoon; Park, Jong-Lyul; Ko, Ji-Yun; Im, Ilkyun; Do, Hyo-Sang; Kim, Hyemin; Tran, Ngoc-Tung; Lee, Sang-Hun; Kim, Yong Sung; Cho, Yee Sook; Lee, Dong Ryul; Han, Yong-Mahn

    2014-04-01

    Genomic imprinting is an epigenetic phenomenon by which a subset of genes is asymmetrically expressed in a parent-of-origin manner. However, little is known regarding the epigenetic behaviors of imprinted genes during human development. Here, we show dynamic epigenetic changes in imprinted genes in hESCs during in vitro differentiation into specialized cell types. Out of 9 imprinted genes with single nucleotide polymorphisms, mono-allelic expression for three imprinted genes (H19, KCNQ1OT1, and IPW), and bi- or partial-allelic expression for three imprinted genes (OSBPL5, PPP1R9A, and RTL1) were stably retained in H9-hESCs throughout differentiation, representing imprinting stability. Three imprinted genes (KCNK9, ATP10A, and SLC22A3) showed a loss and a gain of imprinting in a lineage-specific manner during differentiation. Changes in allelic expression of imprinted genes were observed in another hESC line during in vitro differentiation. These findings indicate that the allelic expression of imprinted genes may be vulnerable in a lineage-specific manner in human pluripotent stem cells during differentiation.

  13. Genomic imprinting: potential function and mechanisms revealed by the Prader-Willi and Angelman syndromes.

    Science.gov (United States)

    Glenn, C C; Driscoll, D J; Yang, T P; Nicholls, R D

    1997-04-01

    The Prader-Willi (PWS) and Angelman (AS) syndromes are two clinically distinct syndromes which result from lack of expression of imprinted genes within chromosome 15q11-q13. These two syndromes result from 15q11-q13 deletions, chromosome 15 uniparental disomy (UPD), imprinting centre mutations and, for AS, probable mutations in a single gene. The differential phenotype results from a paternal genetic deficiency in PWS patients and a maternal genetic deficiency in AS patients. Within 15q11-q13, four genes (SNRPN, IPW, ZNF127, FNZ127) and two expressed sequence tags (PAR1 and PAR5) have been found to be expressed only from the paternally inherited chromosome, and therefore all must be considered candidate genes involved in the pathogenesis of PWS. A candidate AS gene (UBE3A) has very recently been identified. The mechanisms of imprinted gene expression are not yet understood, but it is clear that DNA methylation is involved in both somatic cell expression and inheritance of the imprint. The presence of DNA methylation imprints that distinguish the paternally and maternally inherited alleles is a common characteristic of all known imprinted genes which have been studied extensively, including SNRPN and ZNF127. Recently, several PWS and AS patients have been found that have microdeletions in a region upstream of the SNRPN gene referred to as the imprinting centre, or IC. Paternal IC deletions in PWS patients and maternal IC deletions in AS patients result in uniparental DNA methylation and uniparental gene expression at biparentally inherited loci. The IC is a novel genetic element which controls initial resetting of the parental imprint in the germline for all imprinted gene expression over a 1.5-2.5 Mb region within chromosome 15q11-q13.

  14. Measurements of downwelling far-infrared radiance during the RHUBC-II campaign at Cerro Toco, Chile and comparisons with line-by-line radiative transfer calculations

    Science.gov (United States)

    Mast, Jeffrey C.; Mlynczak, Martin G.; Cageao, Richard P.; Kratz, David P.; Latvakoski, Harri; Johnson, David G.; Turner, David D.; Mlawer, Eli J.

    2017-09-01

    Downwelling radiances at the Earth's surface measured by the Far-Infrared Spectroscopy of the Troposphere (FIRST) instrument in an environment with integrated precipitable water (IPW) as low as 0.03 cm are compared with calculated spectra in the far-infrared and mid-infrared. FIRST (a Fourier transform spectrometer) was deployed from August through October 2009 at 5.38 km MSL on Cerro Toco, a mountain in the Atacama Desert of Chile. There FIRST took part in the Radiative Heating in Unexplored Bands Campaign Part 2 (RHUBC-II), the goal of which is the assessment of water vapor spectroscopy. Radiosonde water vapor and temperature vertical profiles are input into the Atmospheric and Environmental Research (AER) Line-by-Line Radiative Transfer Model (LBLRTM) to compute modeled radiances. The LBLRTM minus FIRST residual spectrum is calculated to assess agreement. Uncertainties (1-σ) in both the measured and modeled radiances are also determined. Measured and modeled radiances nearly all agree to within combined (total) uncertainties. Features exceeding uncertainties can be corrected into the combined uncertainty by increasing water vapor and model continuum absorption, however this may not be necessary due to 1-σ uncertainties (68% confidence). Furthermore, the uncertainty in the measurement-model residual is very large and no additional information on the adequacy of current water vapor spectral line or continuum absorption parameters may be derived. Similar future experiments in similarly cold and dry environments will require absolute accuracy of 0.1% of a 273 K blackbody in radiance and water vapor accuracy of ∼3% in the profile layers contributing to downwelling radiance at the surface.

  15. Fine Particulate Matter Predictions Using High Resolution Aerosol Optical Depth (AOD) Retrievals

    Science.gov (United States)

    Chudnovsky, Alexandra A.; Koutrakis, Petros; Kloog, Itai; Melly, Steven; Nordio, Francesco; Lyapustin, Alexei; Wang, Jujie; Schwartz, Joel

    2014-01-01

    To date, spatial-temporal patterns of particulate matter (PM) within urban areas have primarily been examined using models. On the other hand, satellites extend spatial coverage but their spatial resolution is too coarse. In order to address this issue, here we report on spatial variability in PM levels derived from high 1 km resolution AOD product of Multi-Angle Implementation of Atmospheric Correction (MAIAC) algorithm developed for MODIS satellite. We apply day-specific calibrations of AOD data to predict PM(sub 2.5) concentrations within the New England area of the United States. To improve the accuracy of our model, land use and meteorological variables were incorporated. We used inverse probability weighting (IPW) to account for nonrandom missingness of AOD and nested regions within days to capture spatial variation. With this approach we can control for the inherent day-to-day variability in the AOD-PM(sub 2.5) relationship, which depends on time-varying parameters such as particle optical properties, vertical and diurnal concentration profiles and ground surface reflectance among others. Out-of-sample "ten-fold" cross-validation was used to quantify the accuracy of model predictions. Our results show that the model-predicted PM(sub 2.5) mass concentrations are highly correlated with the actual observations, with out-of- sample R(sub 2) of 0.89. Furthermore, our study shows that the model captures the pollution levels along highways and many urban locations thereby extending our ability to investigate the spatial patterns of urban air quality, such as examining exposures in areas with high traffic. Our results also show high accuracy within the cities of Boston and New Haven thereby indicating that MAIAC data can be used to examine intra-urban exposure contrasts in PM(sub 2.5) levels.

  16. Northeast weather variability and atmospheric teleconnections

    Science.gov (United States)

    Mackey, Frederick Douglas

    This research examined the effects of simultaneous occurrences of different phases of the North Atlantic Oscillation (NAO) and Pacific North American (PNA) teleconnection patterns on daily variations in Northeast climate variables. 30-day normalized Temperature, MSLP, and IPW anomalies gathered from Northeast data locations were compared to daily indices of the NAO and PNA. The computed anomalies from each location were sorted into 25 potential NAO/PNA phase combinations which were based off of the standard deviations of the NAO/PNA daily indices in an 11-year data set from 2004-2014. These anomalies and their relationships to daily NAO/PNA index values were analyzed using regression, correlation, and chi-square analysis. Additionally, each of the 25 combinations and their associated average anomalies were analyzed using composite analysis. This process was done for a full time series and a cool season time series using the months from October-March in the same 11-year data set. Regression analysis revealed that no variation in the analyzed variables can be explained by either the NAO or the PNA daily indices individually or together (using multi-regression). Chi-square analysis revealed that the distribution of the average anomalies associated with the 25 possible combinations was most likely random. Cross correlation tests suggested little to no relationship between daily anomalies in the analyzed variables and the NAO/PNA daily indices. The greatest observed average anomalies in the 25 xv combinations were consistent at 4/5 data locations and in some cases could be explained by composite analysis. The majority of these significant anomalies occurred when either the NAO or PNA was in an extreme phase (Very Positive/Very Negative). The ability to explain some of these average anomalies with composite analyses of the geopotential height field suggests that NAO/PNA daily indices could prove useful for long term forecasting.

  17. Effect of Breastfeeding Promotion on Early Childhood Caries and Breastfeeding Duration among 5 Year Old Children in Eastern Uganda: A Cluster Randomized Trial

    Science.gov (United States)

    Birungi, Nancy; Fadnes, Lars T.; Okullo, Isaac; Kasangaki, Arabat; Nankabirwa, Victoria; Ndeezi, Grace; Tumwine, James K.; Tylleskär, Thorkild; Lie, Stein Atle; Åstrøm, Anne Nordrehaug

    2015-01-01

    Background Although several studies have shown short term health benefits of exclusive breastfeeding (EBF), its long term consequences have not been studied extensively in low-income contexts. This study assessed the impact of an EBF promotion initiative for 6 months on early childhood caries (ECC) and breastfeeding duration in children aged 5 years in Mbale, Eastern Uganda. Methods Participants were recruited from the Ugandan site of the PROMISE- EBF cluster randomised trial (ClinicalTrials.gov no: NCT00397150). A total of 765 pregnant women from 24 clusters were included in the ratio 1:1 to receive peer counselled promotion of EBF as the intervention or standard of care. At the 5 year follow-up, ECC was recorded under field conditions using the World Health Organization’s decayed missing filled tooth (dmft) index. Adjusted negative binomial and linear regression were used in the analysis. Results Mean breastfeeding duration in the intervention and control groups (n=417) were 21.8 (CI 20.7–22.9) and 21.3(CI 20.7–21.9) months, respectively. The mean dmft was 1.5 (standard deviation [SD] 2.9) and 1.7 (SD 2.9) in the intervention and control groups, respectively. Corresponding prevalence estimates of ECC were 38% and 41%. Negative binomial regression analysis adjusted for cluster effects and loss-to-follow-up by inverse probability weights (IPW) showed an incidence-rate ratio (IRR) of 0.91 (95% CI 0.65–1.2). Comparing the effect of the trial arm on breastfeeding duration showed a difference in months of 0.48 (-0.72 to 1.7). Conclusion PROMISE EBF trial did not impact on early childhood caries or breastfeeding duration at 5 years of age. This study contributes to the body of evidence that promotion of exclusive breastfeeding does not raise oral health concerns. However, the high burden of caries calls for efforts to improve the oral health condition in this setting. Trial Registration ClinicalTrials.gov NCT00397150 PMID:25938681

  18. Association between the Fatty Liver Index and Risk of Type 2 Diabetes in the EPIC-Potsdam Study.

    Directory of Open Access Journals (Sweden)

    Susanne Jäger

    Full Text Available The fatty liver index (FLI predicts fatty liver by using BMI, waist circumference, γ-glutamyltransferase and triglycerides. We investigated the association between the FLI and the risk of type 2 diabetes and evaluated to what extent single FLI components contribute to the diabetes risk. We analysed a case-cohort study (random sub-cohort: 1922; incident cases: 563 nested within the European Prospective Investigation into Cancer and Nutrition (EPIC-Potsdam study. The proportion of exposure effect (PEE explained by single FLI components was evaluated and effect decomposition using inverse probability weighting (IPW was applied. Women and men with a FLI ≥ 60 compared to those with a FLI < 30 had a multivariable-adjusted Hazard Ratio (HR of 17.6; 95% confidence interval (CI 11.1-28.0 and HR: 10.9; 95% CI 6.22-19.2, respectively. Adjustment for BMI or waist circumference attenuated this association in men [PEE BMI (95% CI = 53.8% (43.9%-65.8%; PEE waist (95% CI = 54.8% (44.2%-68.8%]. In women, adjustment for waist circumference attenuated the association to a lesser degree than in men [PEE waist (95% CI = 31.1%; (21.9%-43.1%] while BMI had no appreciable effect [PEE BMI (95% CI = 11.0% (2.68%-21.0%]. γ-glutamyltransferase and triglycerides showed only a small attenuation in women [PEE GGT(95% CI = 3.11% (-0.72%-4.48%; PEE TG (95% CI = 6.36% (3.81%-9.92%] and in men [PEE GGT = 0%; PEE TG (95% CI = 6.23% (2.03%-11.8%]. In women, the total effect was decomposed into a direct effect and 4 indirect effects (HR BMI = 1.10; HR waist = 1.28; HR GGT = 0.97 and HR TG = 1.03. In men, the 4 indirect effects were HR BMI = 1.25; HR waist = 1.29; HR GGT = 0.97 and HR TG = 0.99. These data suggest that the FLI, as a proxy for fatty liver, is associated with risk of type 2 diabetes. This association is only partly explained by standard estimates of overall and abdominal body fatness, particularly among women.

  19. Effect of Breastfeeding Promotion on Early Childhood Caries and Breastfeeding Duration among 5 Year Old Children in Eastern Uganda: A Cluster Randomized Trial.

    Directory of Open Access Journals (Sweden)

    Nancy Birungi

    Full Text Available Although several studies have shown short term health benefits of exclusive breastfeeding (EBF, its long term consequences have not been studied extensively in low-income contexts. This study assessed the impact of an EBF promotion initiative for 6 months on early childhood caries (ECC and breastfeeding duration in children aged 5 years in Mbale, Eastern Uganda.Participants were recruited from the Ugandan site of the PROMISE- EBF cluster randomised trial (ClinicalTrials.gov no: NCT00397150. A total of 765 pregnant women from 24 clusters were included in the ratio 1:1 to receive peer counselled promotion of EBF as the intervention or standard of care. At the 5 year follow-up, ECC was recorded under field conditions using the World Health Organization's decayed missing filled tooth (dmft index. Adjusted negative binomial and linear regression were used in the analysis.Mean breastfeeding duration in the intervention and control groups (n=417 were 21.8 (CI 20.7-22.9 and 21.3(CI 20.7-21.9 months, respectively. The mean dmft was 1.5 (standard deviation [SD] 2.9 and 1.7 (SD 2.9 in the intervention and control groups, respectively. Corresponding prevalence estimates of ECC were 38% and 41%. Negative binomial regression analysis adjusted for cluster effects and loss-to-follow-up by inverse probability weights (IPW showed an incidence-rate ratio (IRR of 0.91 (95% CI 0.65-1.2. Comparing the effect of the trial arm on breastfeeding duration showed a difference in months of 0.48 (-0.72 to 1.7.PROMISE EBF trial did not impact on early childhood caries or breastfeeding duration at 5 years of age. This study contributes to the body of evidence that promotion of exclusive breastfeeding does not raise oral health concerns. However, the high burden of caries calls for efforts to improve the oral health condition in this setting.ClinicalTrials.gov NCT00397150.

  20. Causal Inference and Model Selection in Complex Settings

    Science.gov (United States)

    Zhao, Shandong

    Propensity score methods have become a part of the standard toolkit for applied researchers who wish to ascertain causal effects from observational data. While they were originally developed for binary treatments, several researchers have proposed generalizations of the propensity score methodology for non-binary treatment regimes. In this article, we firstly review three main methods that generalize propensity scores in this direction, namely, inverse propensity weighting (IPW), the propensity function (P-FUNCTION), and the generalized propensity score (GPS), along with recent extensions of the GPS that aim to improve its robustness. We compare the assumptions, theoretical properties, and empirical performance of these methods. We propose three new methods that provide robust causal estimation based on the P-FUNCTION and GPS. While our proposed P-FUNCTION-based estimator preforms well, we generally advise caution in that all available methods can be biased by model misspecification and extrapolation. In a related line of research, we consider adjustment for posttreatment covariates in causal inference. Even in a randomized experiment, observations might have different compliance performance under treatment and control assignment. This posttreatment covariate cannot be adjusted using standard statistical methods. We review the principal stratification framework which allows for modeling this effect as part of its Bayesian hierarchical models. We generalize the current model to add the possibility of adjusting for pretreatment covariates. We also propose a new estimator of the average treatment effect over the entire population. In a third line of research, we discuss the spectral line detection problem in high energy astrophysics. We carefully review how this problem can be statistically formulated as a precise hypothesis test with point null hypothesis, why a usual likelihood ratio test does not apply for problem of this nature, and a doable fix to correctly

  1. Anatomic and radiographic measurement for related parameters in term of lower cervical pedicle screw fixation%下颈椎椎弓根螺钉内固定相关参数的解剖学和影像学测量

    Institute of Scientific and Technical Information of China (English)

    刘景堂; 刘兴炎; 唐天驷; 葛宝丰

    2009-01-01

    . Additionally,cervical pedicle width and length,transverse angle (TA) of 100 patients' CT scans of C3-C7 cervical segment were measured.Result:There was no statistic difference between the data of pedicle width and height of 20 cadaver specimens ob-tained from manual and CT measurements individually.At C3-C6,the average internal pedicle width (IPW) ranged from 2.5 to 2.8mm,and the average internal pedicle height(IPH) ranged from 2.9 to 3.0mm.At C7,the IPW and IPH was approximately 4.0mm.The pedicle sagittal angel (SA) was 8.6° at C3,4.6° at C4,-1.3° at C5,-4.0° at C6,and -8.2° at C7 respectively.Based on the CT measurements of 100 patients,the data of the pedicle width varied from a minimum of 3.1mm for the C3 pedicle,to a maximum of 9.3mm for the C7 pedi-cle,and in 92.8% cases,the pedicle width was larger than 3.5mm.Pedicle length (PL) was about 19.1-20.5mm,and total leugth(TL) of pedicle path was about 33.2-35.0mm.The pedicle TA was about 43.2°-45.1°at C3-C5,40.8° at C6,and 37.5 at° C7 respectively.Conclusion:CT measurement can provide valuable datafor cervical pedicle screw placement and lower cervical pedicle can hold screw with 3.5mm diameter.

  2. Influence of plant productivity over variability of soil respiration: a multi-scale approach

    Science.gov (United States)

    Curiel Yuste, J.

    2009-04-01

    .pumpanen@helsinki.fi) 18. Institute for the Study of Earth, Oceans and Space, University of New Hampshire Durham, USA (andrew.richardson@unh.edu) 19. Institute of Plant Sciences, ETH Zurich, Zurich, Switzerland (nadine.ruehr@ipw.agrl.ethz.ch)

  3. GNSS反演资料在GRAPES Meso三维变分中的应用%Operational Assimilation of Data Retrieved by GNSS Observations into GRAPES Meso 3DVar System

    Institute of Scientific and Technical Information of China (English)

    王金成; 龚建东; 邓莲堂

    2014-01-01

    Radio occultation (RO)observations using the Global Navigation Satellite System (GNSS)provides valuable data to support operational numerical weather prediction,and it is proved that the assimilation of RO data has the potential to significantly improve the accuracy of global and regional meteorological analy-sis and weather prediction.RO observations have many advantages such as high precision,global coverage and high vertical resolution compared with other observations.RO observations provide phase (Level 1a), bending angle (Level 1b),refractivity (Level 2a),retrieved pressure,temperature and humidity profiles (Level 2b),all of which can be assimilated into numerical model.Bending angle and refractivity are proved better choices for assimilation as observation operators are less complicated,and have no disadvantages as-sociated with the modeling of ionospheric effects in the assimilation model.However,assimilation of water vapor,temperature or pressure derived from RO observations have advantages that data forms are same as model variables,and it is proved that assimilation of retrieved data also improve the accuracy of global ana-lyses and forecasts significantly. In the operational GRAPES (Global/Regional Assimilation and Prediction System ) regional (GRAPES Meso)3-dimensional variational (3DVar)system,the analysis is performed in model vertical level,but it can only assimilate the upper-level wind,pressure and humidity from radiosonde report (TEMP),upper-level wind and humidity by AIREP,cloud drift wind (SATOB),the pressure from sur-face station report over land (SYNOP)and over sea,integrated column precipitable water vapor (IPW)re-trieved by ground-based GPS observations and radar wind profiles.In order to assimilate RO retrieved at-mosphere data and address their impacts on analyses and forecasts,observation operators of retrieved hu-midity and pressur eassimilation are developed first,and then quality control and vertical thinning scheme are formed and