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Sample records for hat nhan vao

  1. VAO Tools Enhance CANDELS Research Productivity

    Science.gov (United States)

    Greene, Gretchen; Donley, J.; Rodney, S.; LAZIO, J.; Koekemoer, A. M.; Busko, I.; Hanisch, R. J.; VAO Team; CANDELS Team

    2013-01-01

    The formation of galaxies and their co-evolution with black holes through cosmic time are prominent areas in current extragalactic astronomy. New methods in science research are building upon collaborations between scientists and archive data centers which span large volumes of multi-wavelength and heterogeneous data. A successful example of this form of teamwork is demonstrated by the CANDELS (Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey) and the Virtual Astronomical Observatory (VAO) collaboration. The CANDELS project archive data provider services are registered and discoverable in the VAO through an innovative web based Data Discovery Tool, providing a drill down capability and cross-referencing with other co-spatially located astronomical catalogs, images and spectra. The CANDELS team is working together with the VAO to define new methods for analyzing Spectral Energy Distributions of galaxies containing active galactic nuclei, and helping to evolve advanced catalog matching methods for exploring images of variable depths, wavelengths and resolution. Through the publication of VOEvents, the CANDELS project is publishing data streams for newly discovered supernovae that are bright enough to be followed from the ground.

  2. Characterization of Two VAO-Type Flavoprotein Oxidases from Myceliophthora thermophila

    Directory of Open Access Journals (Sweden)

    Alessandro R. Ferrari

    2018-01-01

    Full Text Available The VAO flavoprotein family consists mostly of oxidoreductases harboring a covalently linked flavin cofactor. The linkage can be either monocovalent at position 8 with a histidine or tyrosine or bicovalent at position 8 with a histidine and at position 6 with a cysteine. Bicovalently bound flavoproteins show a preference for bulkier substrates such as oligosaccharides or secondary metabolites. The genome of the thermophilic fungus Myceliophthora thermophila C1 was found to be rich in genes encoding putative covalent VAO-type flavoproteins. Enzymes from this fungus have the advantage of being rather thermostable and homologous overexpression in M. thermophila C1 is feasible. Recently we discovered a new and VAO-type carbohydrate oxidase from this fungus: xylooligosaccharide oxidase. In this study, two other putative VAO-type oxidases, protein sequence XP_003663615 (MtVAO615 and XP_003665713 (MtVAO713, were expressed in M. thermophila C1, purified and characterized. Enzyme MtVAO615 was found to contain a bicovalently bound FAD, while enzyme MtVAO713 contained a monocovalent histidyl-bound FAD. The crystal structures of both proteins were obtained which revealed atypical active site architectures. It could be experimentally verified that both proteins, when reduced, rapidly react with molecular oxygen, a hallmark of flavoprotein oxidases. A large panel of alcohols, including carbohydrates, steroids and secondary alcohols were tested as potential substrates. For enzyme MtVAO713 low oxidase activity was discovered towards ricinoleic acid.

  3. Ciclovía y carril bus en el VAO de la C58

    OpenAIRE

    Moreno Carral, Cristóbal

    2017-01-01

    El proyecto de la "ciclovía y carril bus en la infraestructura del VAO de la C58" se inicia en el taller PCH Ciutat Meridiana como una manera de mejorar el lugar gracias a la conectividad. Se desarrolla como PFC con Claudi Aguiló (Construcción) como tutor y Xavier Matilla (Urbanismo) e Ignacio Costales (Estructura) como asesores. El proyecto consiste en la adaptación de la infraestructura del VAO mediante la creación de nuevos accesos (Proyecto urbano) que puedan dotar a la plataforma existen...

  4. Power start up of the Dalat nuclear research reactor; Khoi dong nang luong lo phan ung hat nhan Da Lat

    Energy Technology Data Exchange (ETDEWEB)

    Hien, Pham Duy; Huy, Ngo Quang; Long, Vu Hai; Mai, Tran Khanh [Nuclear Research Inst., Da Lat (Viet Nam)

    1994-10-01

    After accomplishing the physical start-up of the reactor, the power start-up was carried out in February 1984. The power of the reactor has reached: 10 KW on 6/2/1984, 100 KW on 7/2/1984, 200 KW and 300 KW on 8/2/1984; 400 KW and nominal power 500 KW on 9/2/1984. The reactivity temperature coefficient and the xenon poisoning were determined. 3 figs., 12 tabs.

  5. Hat cycle dynamic simulation

    International Nuclear Information System (INIS)

    Trucco, A.; Corallo, C.; Pini Prato, A.; Porro, S.

    1999-01-01

    Among the innovative cycle recently proposed in literature, the Humid Air Turbine Cycle - Hat better seems to fulfil the main energy market requirements of today: High efficiency in a large power ranger, low pollution, low specific capital cost. The previous results of an analysis at partial load and transient conditions are here presented, where the Hat plant has been simulated using the original model implemented in LEGO environment [it

  6. Hard-hat day

    CERN Multimedia

    2003-01-01

    CERN will be organizing a special information day on Friday, 27th June, designed to promote the wearing of hard hats and ensure that they are worn correctly. A new prevention campaign will also be launched.The event will take place in the hall of the Main Building from 11.30 a.m. to 2.00 p.m., when you will be able to come and try on various models of hard hat, including some of the very latest innovative designs, ask questions and pass on any comments and suggestions.

  7. Physical Characteristics of the Dalat Nuclear Research Reactor; Cac dac trung vat ly lo cua lo phan ung hat nhan Da Lat

    Energy Technology Data Exchange (ETDEWEB)

    Huy, Ngo Quang [ed.; Nuclear Research Inst., Da Lat (Viet Nam)

    1994-10-01

    The operation of the TRIGA MARK II reactor of nominal power 250 KW has been stopped as all the fuel elements have been dismounted and taken away in 1968. The reconstruction of the reactor was accomplished with Russian technological assistance after 1975. The nominal power of the reconstructed reactor is of 500 KW. The recent Dalat reactor is unique of its kind in the world: Russian-designed core combined with left-over infrastructure of the American-made TRIGA II. The reactor was loaded in November 1983. It has reached physical criticality on 1/11/1983 (without central neutron trap) and on 18/12/1983 (with central neutron trap). The power start up occurred in February 1984 and from 20/3/1984 the reactor began to be operated at the nominal power 500 KW. The selected reports included in the proceedings reflect the start up procedures and numerous results obtained in the Dalat Nuclear Research Institute and the Centre of Nuclear Techniques on the determination of different physical characteristics of the reactor. These characteristics are of the first importance for the safe operation of the Dalat reactor.

  8. 'Nederlandismes' in HAT

    Directory of Open Access Journals (Sweden)

    F. van Houwelingen

    1998-04-01

    Full Text Available Dutch influence in HAT (1994 Although there is consensus among linguists that Afrikaans and Dutch are related languages, and that Afrikaans originated from 17th century Dutch, the differences between present-day varieties of Afrikaans and Dutch serve as proof that we are dealing with two separate languages. These differences should be clearly visible in descriptive as well as normative sources of the two languages. However, the third edition of Verklarende Handewoordeboek van die Afrikaanse Taal (HAT, one of the leading Afrikaans standard monolingual dictionaries, contains headwords as well as microstructural information that do not agree with the reality of the Afrikaans of today. An empirical investigation conducted among Afrikaans-speaking dictionary users has proven that a significant Dutch influence is still prominent - in the micro- as well as the macrostructure of the dictionary. It is believed that the Dutch "thread" of many Afrikaans dictionaries has indirectly contributed towards the creation of a super-standard norm, which is partially responsible for the estrangement between the cultural language and the vernacular.

  9. HAT-P-25b

    DEFF Research Database (Denmark)

    Quinn, S.N.; Bakos, G. 'A; Hartman, J.

    2012-01-01

    We report the discovery of HAT-P-25b, a transiting extrasolar planet orbiting the V = 13.19 G5 dwarf star GSC 1788-01237, with a period P = 3.652836 +/- 0.000019 days, transit epoch Tc = 2455176.85173 +/- 0.00047 (BJD), and transit duration 0.1174 +/- 0.0017 days. The host star has mass of 1.01 +...

  10. HAT-P-16b

    DEFF Research Database (Denmark)

    Buchhave, Lars A.; Bakos, G. A.; Hartman, J. D.

    2010-01-01

    We report the discovery of HAT-P-16b, a transiting extrasolar planet orbiting the V = 10.8 mag F8 dwarf GSC 2792-01700, with a period P = 2.775960 ± 0.000003 days, transit epoch Tc = 2455027.59293 ± 0.00031 (BJD10), and transit duration 0.1276 ± 0.0013 days. The host star has a mass of 1.22 ± 0.0...

  11. HAT-P-38h

    DEFF Research Database (Denmark)

    Sato, Bun'ei; Hartman, Joel D.; Bakos, Gaspar Á.

    2012-01-01

    We report on the discovery of HAT-P-38b, a Saturn-mass exoplanet, transiting the V = 12.56 dwarf star GSC 2314-00559 on a P = 4.6404 d circular orbit. The host star is a 0.89 M-circle dot late G dwarf, with solar metallicity and a radius of 0.92 R-circle dot. The planetary companion has a mass of...

  12. ERRATUM: Work smart, wear your hard hat

    CERN Multimedia

    2003-01-01

    An error appeared in the article «Work smart, wear your hard hat» published in Weekly Bulletin 27/2003, page 5. The impact which pierced a hole in the hard hat worn by Gerd Fetchenhauer was the equivalent of a box weighing 5 kg and not 50 kg.

  13. Become a CERN WhiteHat

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    Discovering CERN's weaknesses is as important as ever. Become a CERN WhiteHat and help us poking around CERN computing services and web applications. All you need is to apply and get the appropriate training...

  14. "Work smart, wear your hard hat"

    CERN Multimedia

    2003-01-01

    Falling objects and collisions are frequent occurrences in work sites and hazardous areas. Hard hats can help prevent many types of accident and can even save lives. Just imagine an 800 g spanner falling from a 13 m high scaffold onto the head of someone standing below - a nightmare scenario! The impact to the head is equivalent to that of a 5 kg weight falling from 2 metres. That is just what happened to Gerd Fetchenhauer when he was working on the UA1 experiment. Fortunately, he was wearing a hard hat at the time. "That hat saved my life," he explains. "It punched a hole right through the hat and I was a bit dazed for a couple of hours but otherwise I was OK." Since that day, Gerd Fetchenhauer, now working on CMS, is never seen on a work site without his hard hat on. Work sites have proliferated at CERN with the construction of the LHC and its detectors, and the wearing of hard hats is compulsory (not to mention life-saving). In the underground caverns and experiment halls, where gantry cranes and other h...

  15. Physical start up of the Dalat nuclear research reactor with the core configuration having a central neutron trap; Khoi dong vat ly lo phan ung hat nhan Da Lat voi cau hinh vung hoat co bay notron

    Energy Technology Data Exchange (ETDEWEB)

    Hien, Pham Duy; Huy, Ngo Quang; Long, Vu Hai; Mai, Tran Khanh [Nuclear Research Inst., Da Lat (Viet Nam)

    1994-10-01

    After the reactor has reached physical criticality with the core configuration exempt from central neutron trap on 1 November 1983, the core configuration with a central neutron trap has been arranged in the reactor and the reactor has reached physical criticality with this core configuration at 17h48 on 18 December 1983. The integral worths of different control rods are determined with accuracy. 2 refs., 24 figs., 18 tabs.

  16. Physical start up of the Dalat nuclear research reactor with the core configuration exempt from neutron trap; Khoi dong vat ly lo phan ung hat nhan Da Lat voi cau hinh vung hoat khong co bay notron

    Energy Technology Data Exchange (ETDEWEB)

    Hien, Pham Duy; Huy, Ngo Quang; Long, Vu Hai; Mai, Tran Khanh [Nuclear Research Inst., Da Lat (Viet Nam)

    1994-10-01

    The nominal power of the reconstructed Dalat reactor is of 500 KW. After a meticulous preparation the Russian and Vietnamese teams have proceeded to the physical reactor start-up in November 1983 with the core configuration exempt from the neutron trap. The reactor has reached the physical criticality at 19h50 on 1 November 1983. The report delineates different steps of the start-up procedure. 2 refs., 3 figs., 7 tabs.

  17. James J. Gallagher: Man in the White Hat

    Science.gov (United States)

    Jolly, Jennifer L.; Robinson, Ann

    2014-01-01

    In classic Western movies, the good guy could be frequently identified by his trademark white Stetson hat, whereas the bad guy always wore black. James J. Gallagher wore many hats during his career that spanned over six decades; he too would be known as the "man in the white hat,"--trusted to do the right thing. From 1967 to 1970,…

  18. Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p

    Directory of Open Access Journals (Sweden)

    Greenblatt Jack F

    2007-09-01

    Full Text Available Abstract Background Histone modifications have been implicated in the regulation of transcription and, more recently, in DNA replication and repair. In yeast, a major conserved histone acetyltransferase, Hat1p, preferentially acetylates lysine residues 5 and 12 on histone H4. Results Here, we report that a nuclear sub-complex consisting of Hat1p and its partner Hat2p interacts physically and functionally with the origin recognition complex (ORC. While mutational inactivation of the histone acetyltransferase (HAT gene HAT1 alone does not compromise origin firing or initiation of DNA replication, a deletion in HAT1 (or HAT2 exacerbates the growth defects of conditional orc-ts mutants. Thus, the ORC-associated Hat1p-dependent histone acetyltransferase activity suggests a novel linkage between histone modification and DNA replication. Additional genetic and biochemical evidence points to the existence of partly overlapping histone H3 acetyltransferase activities in addition to Hat1p/Hat2p for proper DNA replication efficiency. Furthermore, we demonstrated a dynamic association of Hat1p with chromatin during S-phase that suggests a role of this enzyme at the replication fork. Conclusion We have found an intriguing new association of the Hat1p-dependent histone acetyltransferase in addition to its previously known role in nuclear chromatin assembly (Hat1p/Hat2p-Hif1p. The participation of a distinct Hat1p/Hat2p sub-complex suggests a linkage of histone H4 modification with ORC-dependent DNA replication.

  19. Long-term surveillance plan for the Mexican Hat disposal site Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1997-06-01

    This long-term surveillance plan (LTSP) describes the U.S. Department of Energy's (DOE) long-term care program for the Uranium Mill Tailings Remedial Action (UMTRA) Project Mexican Hat, Utah, disposal site. This LSTP describes the long-term surveillance program the DOE will implement to ensure the Mexican Hat disposal site performs as designed and is cared for in a manner that protects the public health and safety and the environment. Before each disposal site is licensed for custody and long-term care, the Nuclear Regulatory Commission (NRC) requires the DOE to submit such a site-specific LTSP

  20. DIY teleport hats - the consolation of technology

    DEFF Research Database (Denmark)

    Hansen, Lone Koefoed

    2009-01-01

    or biking there. This particular set is made in the free-form crochet style: there is no exact pattern to crochet from, instead you crochet in an iterative process alternating between crocheting and trying the hat on for size and pattern adaptations. Disclaimer: It is of course not a functioning device...... but it works well as a gift for someone you miss or someone who misses another person madly as it provides an opportunity to take some kind of action when ordinary options like driving, jetting or biking are not feasible even if the action is only symbolic....

  1. Engineering assessment of inactive uranium mill tailings: Mexican Hat Site, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1981-09-01

    Ford, Bacon and Davis Utah Inc. has reevaluated the Mexican Hat site in order to revise the March 1977 engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at Mexican Hat, Utah. This engineering assessment has included the preparation of topographic maps, the performance of core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and radiation exposures of individuals and nearby populations, the investigations of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions. Radon gas released from the 2.2 million tons of tailings at the Mexican Hat site constitutes the most significant environmental impact, although windblown tailings and external gamma radiation also are factors. The four alternative actions presented in this engineering assessment range from millsite decontamination with the addition of 3 m of stabilization cover material to removal of the tailings to remote disposal sites and decontamination of the tailings site. Cost estimates for the four options range from about $15,200,000 for stabilization in place, to about $45,500,000 for disposal at a distance of about 16 mi. Three principal alternatives for the reprocessing of the Mexican Hat tailings were examined: heap leaching; treatment at an existing mill; and reprocessing at a new conventional mill constructed for tailings reprocessing. The cost of the uranium recovered would be about $115/lb of U 3 O 8 whether by heap leach or conventional plant processes. The spot market price for uranium was $25/lb early in 1981. Reprocessing the Mexican Hat tailings for uranium recovery is not economically attractive under present conditions

  2. Engineering assessment of inactive uranium mill tailings: Mexican Hat site, Mexican Hat, Utah. Summary

    International Nuclear Information System (INIS)

    1981-09-01

    Ford, Bacon and Davis Utah Inc. has reevaluated the Mexican Hat site in order to revise the March 1977 engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at Mexican Hat, Utah. This engineering assessment has included the preparation of topographic maps, the performance of core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and radiation exposures of individuals and nearby populations, the investigations of site hydrology and meteorology, and the investigations of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions. Radon gas released from the 2.2 million tons of tailings at the Mexican Hat site constitutes the most significant environmental impact, although windblown tailings and external gamma radiation also are factors. The four alternative actions presented in this engineering assessment range from millsite decontamination with the addition of 3 m of stabilization cover material to removal of the tailings to remote disposal sites and decontamination of the tailings site. Cost estimates for the four options range from about $15,200,000 for stabilization in place, to about $45,500,000 for disposal at a distance of about 16 mi. Three principal alternatives for the reprocessing of the Mexican Hat tailings were examined: (a) heap leaching; treatment at an existing mill; and reprocessing at a new conventional mill constructed for tailings reprocessing. The cost of the uranium recovered would be about $115/lb of U 3 O 8 whether by heap leach or conventional plant processes. The spot market price for uranium was $25/lb early in 1981. Reprocessing the Mexican Hat tailings for uranium recovery is not economically attractive under present conditions

  3. HATS-43b, HATS-44b, HATS-45b, and HATS-46b: Four Short-period Transiting Giant Planets in the Neptune–Jupiter Mass Range

    Science.gov (United States)

    Brahm, R.; Hartman, J. D.; Jordán, A.; Bakos, G. Á.; Espinoza, N.; Rabus, M.; Bhatti, W.; Penev, K.; Sarkis, P.; Suc, V.; Csubry, Z.; Bayliss, D.; Bento, J.; Zhou, G.; Mancini, L.; Henning, T.; Ciceri, S.; de Val-Borro, M.; Shectman, S.; Crane, J. D.; Arriagada, P.; Butler, P.; Teske, J.; Thompson, I.; Osip, D.; Díaz, M.; Schmidt, B.; Lázár, J.; Papp, I.; Sári, P.

    2018-03-01

    We report the discovery of four short-period extrasolar planets transiting moderately bright stars from photometric measurements of the HATSouth network coupled to additional spectroscopic and photometric follow-up observations. While the planet masses range from 0.26 to 0.90 {M}{{J}}, the radii are all approximately a Jupiter radii, resulting in a wide range of bulk densities. The orbital period of the planets ranges from 2.7 days to 4.7 days, with HATS-43b having an orbit that appears to be marginally non-circular (e = 0.173 ± 0.089). HATS-44 is notable for having a high metallicity ([{Fe}/{{H}}] = 0.320 ± 0.071). The host stars spectral types range from late F to early K, and all of them are moderately bright (13.3 Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. This paper includes data gathered with the MPG 2.2 m and ESO 3.6 m telescopes at the ESO Observatory in La Silla. This paper includes data gathered with the 6.5 meter Magellan Telescopes located at Las Campanas Observatory, Chile.

  4. WARM SPITZER PHOTOMETRY OF THREE HOT JUPITERS: HAT-P-3b, HAT-P-4b AND HAT-P-12b

    Energy Technology Data Exchange (ETDEWEB)

    Todorov, Kamen O. [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Deming, Drake [Department of Astronomy, University of Maryland at College Park, College Park, MD 20742 (United States); Knutson, Heather A. [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Burrows, Adam [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Fortney, Jonathan J.; Laughlin, Gregory [Department of Astronomy and Astrophysics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States); Lewis, Nikole K. [Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Cowan, Nicolas B. [Department of Physics and Astronomy, Northwestern University, Evanston, IL 60208 (United States); Agol, Eric [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Desert, Jean-Michel [Astronomy Department, California Institute of Technology, Pasadena, CA 91125 (United States); Sada, Pedro V. [Department of Physics and Mathematics, University of Monterrey, Monterrey (Mexico); Charbonneau, David [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Langton, Jonathan [Department of Physics, Principia College, Elsah, IL 62028 (United States); Showman, Adam P. [Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721 (United States)

    2013-06-20

    We present Warm Spitzer/IRAC secondary eclipse time series photometry of three short-period transiting exoplanets, HAT-P-3b, HAT-P-4b and HAT-P-12b, in both the available 3.6 and 4.5 {mu}m bands. HAT-P-3b and HAT-P-4b are Jupiter-mass objects orbiting an early K and an early G dwarf star, respectively. For HAT-P-3b we find eclipse depths of 0.112%+0.015%-0.030% (3.6 micron) and 0.094%+0.016%-0.009% (4.5 {mu}m). The HAT-P-4b values are 0.142%+0.014%-0.016% (3.6 micron) and 0.122%+0.012%-0.014% 4.5 {mu}m). The two planets' photometry is consistent with inefficient heat redistribution from their day to night sides (and low albedos), but it is inconclusive about possible temperature inversions in their atmospheres. HAT-P-12b is a Saturn-mass planet and is one of the coolest planets ever observed during secondary eclipse, along with the hot Neptune GJ 436b and the hot Saturn WASP-29b. We are able to place 3{sigma} upper limits on the secondary eclipse depth of HAT-P-12b in both wavelengths: <0.042% (3.6 {mu}m) and <0.085% (4.5 {mu}m). We discuss these results in the context of the Spitzer secondary eclipse measurements of GJ 436b and WASP-29b. It is possible that we do not detect the eclipses of HAT-P-12b due to high eccentricity, but find that weak planetary emission in these wavelengths is a more likely explanation. We place 3{sigma} upper limits on the |e cos {omega}| quantity (where e is eccentricity and {omega} is the argument of periapsis) for HAT-P-3b (<0.0081) and HAT-P-4b (<0.0042), based on the secondary eclipse timings.

  5. Spitzer Secondary Eclipses of HAT-P-13b

    Science.gov (United States)

    Hardy, Ryan A.; Harrington, J.; Hardin, M. R.; Madhusudhan, N.; Cubillos, P.; Blecic, J.; Bakos, G.; Hartman, J. D.

    2013-10-01

    HAT-P-13 b is a transiting hot Jupiter with a slightly eccentric orbit (e = 0.010) inhabiting a two-planet system. The two-planet arrangement provides an opportunity to probe the interior structure of HAT-P-13b. Under equilibrium-tide theory and confirmation that the apsides of planets b and c are in alignment, a measurement of the planet's eccentricity can be related to the planet's tidal Love number k2, which describes the central condensation of the planet's mass and its deformation under tidal effects. A measurement of k2 could constrain interior models of HAT-P-13b. HAT-P-13b's orbit is configured favorably for refinement of the eccentricity by secondary eclipse timing observations, which provide direct measurements of ecosω. In 2010, Spitzer observed two secondary eclipses of HAT-P-13b in the 3.6- and 4.5-μm IRAC bandpasses. We present secondary eclipse times and depths; joint models of the HAT-P-13 system that incorporate transit photometry and radial velocity data; and constraints on the atmospheric chemistry of HAT-P-13b that suggest solar-abundance composition without a thermal inversion. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA, which provided support for this work. This work was supported in part by NASA Planetary Atmospheres Grant NNX13AF38G.

  6. The "Burgundian" hat from Herjolfsnes, Greenland: new discoveries, new dates

    DEFF Research Database (Denmark)

    Smith, Michèle Hayeur; Arneborg, Jette; Smith, Kevin

    2016-01-01

    of the Greenland Norse colony but also its enduring cultural links with continental European fashions, following a comment to this effect published by Nørlund himself. In 1996, the hat was dated to the early fourteenth century by Arneborg, a century earlier than Nørlund’s dating, based on stylistic comparisons...... with European examples. Recent research on North Atlantic textiles led to a re-examination of the hat, with different sections sampled and resubmitted for accelerated mass spectrometry dating. The results suggest that the body of the hat and its crown are of different periods with c. 100 years between them...

  7. The boson and the Mexican hat

    International Nuclear Information System (INIS)

    Cohen-Tannoudji, Gilles; Spiro, Michel

    2013-01-01

    This document contains a brief presentation and the table of contents of a book in which the authors who reports the evolutions of the contemporary astrophysics theories, and the scientific, technological and human adventure of the CERN until the discovery of the Higgs boson by means of the LHC. The Mexican hat is the name given to the mechanism by which the boson reports the origin of the elementary particle masses. The first part reports the boson genealogy: the law of universal gravitation, the relativity and the limits of the rational mechanics, quantum mechanics, and particle physics at the end of the 1960's. The second part addresses the necessary existence of the boson: quantum electrodynamics, from the quark model to quantum chromo-dynamics, from intermediate bosons to the Brout, Englert and Higgs boson, the standard cosmology model. The third part deals with the perspectives opened by the existence and evidence of the boson: the search for physics theory and models beyond standard models

  8. Long-term surveillance plan for the Mexican Hat disposal site Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1997-05-01

    This long-term surveillance plan (LTSP) describes the U.S. Department of Energy's (DOE) long-term care program for the Uranium Mill Tailings Remedial Action (UMTRA) Project Mexican Hat, Utah, disposal site. The U.S. Nuclear Regulatory Commission (NRC) has developed regulations for the issuance of a general license for the custody and long-term care of UMTRA Project disposal sites in 10 CFR Part 40. The purpose of this general license is to ensure that the UMTRA Project disposal sites will be cared for in a manner that protects the public health and safety and the environment. Before each disposal site is licensed, the NRC requires the DOE to submit a site-specific LTSP. The DOE prepared this LTSP to meet this requirement for the Mexican Hat disposal site. The general license becomes effective when the NRC concurs with the DOE's determination of completion of remedial action for the disposal site and the NRC formally accepts this LTSP. This LTSP describes the long-term surveillance program the DOE will implement to ensure that the Mexican Hat disposal site performs as designed. The program is based on two distinct types of activities: (1) site inspections to identify potential threats to disposal cell integrity, and (2) monitoring of selected seeps to observe changes in flow rates and water quality. The LTSP is based on the UMTRA Project long-term surveillance program guidance and meets the requirements of 10 CFR section 40.27(b) and 40 CFR section 192.03. 18 refs., 6 figs., 1 tab

  9. Long-term surveillance plan for the Mexican Hat disposal site, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1996-01-01

    This plan describes the long-term surveillance activities for the Uranium Mill Tailings Remedial Action (UMTRA) Project disposal site at Mexican Hat, Utah. The US Department of Energy (DOE) will carry out these activities to ensure that the disposal site continues to function as designed. This long-term surveillance plan (LTSP) was prepared as a requirement for acceptance under the US Nuclear Regulatory Commission (NRC) general license for custody and long-term care of residual radioactive material (RRM). This LTSPC documents the land ownership interests and details how the long-term care of the disposal site will be accomplished

  10. Bi-Directional Communication: A Critical Component of HAT

    Science.gov (United States)

    Shively, Robert J.

    2016-01-01

    Known problems with automation include lack of mode awareness, automation brittleness, and risk of miscalibrated trust. Human-Autonomy Teaming (HAT) is essential for improving these problems. This presentation outlines critical components for Human-Autonomy Teaming.

  11. Application of Six Thinking Hats with the Theme „Profession of Sociologist”. Transcript of the Sequence of Green Hat

    Directory of Open Access Journals (Sweden)

    Gheorghe Onuţ

    2009-12-01

    Full Text Available The study is the transcription of the sequence of green hat from the application of the creative technique Six Thinking Hats (Edward de Bono’s creation that I did at the workshop with the theme „Profession of Sociologist”, of the international colloquium of social sciences ACUM 2008. The colloquium ACUM is the most important of the scientific manifestations organized by the Faculty of Law and Sociology of „Transilvania” University of Braşov.

  12. Long-term surveillance plan for the Mexican Hat Disposal Site, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1996-02-01

    This plan describes the long-term surveillance activities for the Uranium Mill Tailings Remedial Action (UMTRA) Project disposal site at Mexican Hat, Utah. The U.S. Department of Energy (DOE) will carry out these activities to ensure that the disposal site continues to function as designed. This long-term surveillance plan (LTSP) was prepared as a requirement for acceptance under the U.S. Nuclear Regulatory Commission (NRC) general license for custody and long-term care of residual radioactive material (RRM). This LTSP (based on the DOE's Guidance for Implementing the UMTRA Project Long-term Surveillance Program), documents the land ownership interests and details how the long-term care of the disposal site will be accomplished

  13. Environmental assessment of remedial action at the Mexican Hat uranium mill tailings site, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1987-10-01

    This document assesses the environmental impacts of the proposed remedial action at the Mexican Hat uranium mill tailings site located on the Navajo Reservation in southern Utah. The site covers 235 acres and contains 69 acres of tailings and several of the original mill structures. Remedial action must be performed in accordance with standards and with the concurrence of the US Nuclear Regulatory Commission and the Navajo Nation. The proposed action is to stabilize the tailings within the present tailings site by consolidating the tailings and associated contaminated soils into a recontoured pile. A radon barrier of compacted earth would be constructed over the pile, and various erosion control measures would be taken to assure the long-term stability of the pile. The no action alternative is also assessed in this document. 240 refs., 12 figs., 20 tabs

  14. Probing the parameters of the HAT-P-2 system

    Science.gov (United States)

    Bailey, Elizabeth; Naoz, Smadar; Batygin, Konstantin

    2018-04-01

    The HAT-P-2 system contributes an exceptional set of parameters to the exoplanetary inventory. HAT-P-2b weighs in at approximately 9 Jupiter masses, residing on one of the most eccentric, close-in orbits of any hot Jupiter (e~0.5, a~0.07). The identification of an RV trend points to the existence of an additional, long-period companion, which may have facilitated Kozai-Lidov cycles in the system over its multi-Gyr history. The well-constrained parameters of HAT-P-2b present an opportunity to predict the parameters of the perturber, and furthermore, to assess the tidal dissipation involved in the system's evolution. In this work, we employ an octupole-level secular model to account for the interaction of the two massive planets, thus classifying the system's deviations away from purely quadrupolar dynamics.

  15. Broad-band spectrophotometry of HAT-P-32 b

    DEFF Research Database (Denmark)

    Mallonn, M.; Bernt, I.; Herrero, E.

    2016-01-01

    Multicolour broad-band transit observations offer the opportunity to characterize the atmosphere of an extrasolar planet with small- to medium-sized telescopes. One of the most favourable targets is the hot Jupiter HAT-P-32 b. We combined 21 new transit observations of this planet with 36 previou...... makes a recent tentative detection of a scattering feature less likely. Instead, the available spectral measurements of HAT-P-32 b favour a completely flat spectrum from the near-UV to the near-IR. A plausible interpretation is a thick cloud cover at high altitudes....

  16. Effectiveness Of Six Thinking Hats Training In Improving The ...

    African Journals Online (AJOL)

    This study investigated the effectiveness of Six Thinking Hats Training in improving the psychological well- being of prisoners. The study consisted of 24 convicted prisoners whose ages ranged from 19-60 years with a mean of 22.50 years. A 2x2 experimental group design was adopted, and subjects were randomly ...

  17. FACTORS & ELEMENTAL ANALYSIS OF SIX THINKING HATS TECHNIQUE USING ABCD FRAMEWORK

    OpenAIRE

    Dr. P. S. Aithal; V. T. Shailashree; Dr. P. M. Suresh Kumar

    2017-01-01

    De Bono's Six Thinking Hats technique suggests different types of thinking corresponding to six thinking roles for the analyst, associated with hats of six different colors. The technique correlates different thinking styles used in a systematic problem solving procedure with different coloured hats. Alternately, by conceptualizing each type of hat, the person focuses on the style of thinking associated with each colour so that the problem can be analysed from different angles and frame of re...

  18. Measurements of the UVR protection provided by hats used at school.

    Science.gov (United States)

    Gies, Peter; Javorniczky, John; Roy, Colin; Henderson, Stuart

    2006-01-01

    The importance of protection against solar ultraviolet radiation (UVR) in childhood has lead to SunSmart policies at Australian schools, in particular primary schools, where children are encouraged and in many cases required to wear hats at school. Hat styles change regularly and the UVR protection provided by some of the hat types currently used and recommended for sun protection by the various Australian state cancer councils had not been previously evaluated. The UVR protection of the hats was measured using UVR sensitive polysulphone film badges attached to different facial sites on rotating headforms. The sun protection type hats included in this study were broad-brimmed hats, "bucket hats" and legionnaires hats. Baseball caps, which are very popular, were also included. The broad-brimmed hats and bucket hats provided the most UVR protection for the six different sites about the face and head. Legionnaires hats also provided satisfactory UVR protection, but the caps did not provide UVR protection to many of the facial sites. The highest measured UVR protection factors for facial sites other than the forehead were 8 to 10, indicating that, while some hats can be effective, they need to be used in combination with other forms of UVR protection.

  19. Atmospheric Retrievals of HAT-P-16b and WASP-11b/HAT-P-10b

    Science.gov (United States)

    McIntyre, Kathleen; Harrington, Joseph; Challener, Ryan; Lenius, Maria; Hartman, Joel D.; Bakos, Gaspar A.; Blecic, Jasmina; Cubillos, Patricio E.; Cameron, Andrew

    2018-01-01

    We report Bayesian atmospheric retrievals performed on the exoplanets HAT-P-16b and WASP-11b/HAT-P-10b. HAT-P-16b is a hot (equilibrium temperature 1626 ± 40 K, assuming zero Bond albedo and efficient energy redistribution), 4.19 ± 0.09 Jupiter-mass exoplanet orbiting an F8 star every 2.775960 ± 0.000003 days (Buchhave et al 2010). WASP-11b/HAT-P-10b is a cooler (1020 ± 17 K), 0.487 ± 0.018 Jupiter-mass exoplanet orbiting a K3 star every 3.7224747 ± 0.0000065 days (Bakos et al. 2009, co-discovered by West et al. 2008). We observed secondary eclipses of both planets using the 3.6 μm and 4.5 μm channels of the Spitzer Space Telescope's Infrared Array Camera (program ID 60003). We applied our Photometry for Orbits, Eclipses, and Transits (POET) code to produce normalized eclipse light curves, and our Bayesian Atmospheric Radiative Transfer (BART) code to constrain the temperature-pressure profiles and atmospheric molecular abundances of the two planets. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

  20. Thermodynamic studies of a HAT cycle and its components

    International Nuclear Information System (INIS)

    Nyberg, Bjoern; Thern, Marcus

    2012-01-01

    Highlights: → Performance maps for HAT cycles with different complexity are shown. → A suggestion, where to extract cooling air for the turbine is presented. → The influence of the makeup water on total efficiency is shown. → The optimal pressure level for intercooling is described. -- Abstract: The electric power grid contains more and more renewable power production such as wind and solar power. The use of renewable power sources increases the fluctuations in the power grid which increase the demand for highly efficient, fast-starting power-producing units that can cope with sudden production losses. One of the more innovative power plant cycles, that have the potential of competing with conventional combined power plants in efficiency but has a higher availability and faster start up time, is the Evaporative Gas Turbine (EvGT) or Humid Air Turbine (HAT). A thermodynamic evaluation of different HAT cycle layouts has been done in this paper. Each layout is evaluated separately which makes it possible to study different components individual contribution to the efficiency and specific power. The thermodynamic evaluation also shows that it is important to look at different cool-flow extracting positions. The effect of water temperature entering the cycle, called make-up water, and where it is introduced into the cycle has been evaluated. The make-up water temperature also affects the optimal pressure level for intercooling and it is shown that an optimal position can be decided considering design parameters of the compressor and the water circuit.

  1. Criticality in the configuration-mixed interacting boson model (1) $U(5)-\\hat{Q}(\\chi)\\cdot\\hat{Q}(\\chi)$ mixing

    CERN Document Server

    Hellemans, V; De Baerdemacker, S; Heyde, K

    2008-01-01

    The case of U(5)--$\\hat{Q}(\\chi)\\cdot\\hat{Q}(\\chi)$ mixing in the configuration-mixed Interacting Boson Model is studied in its mean-field approximation. Phase diagrams with analytical and numerical solutions are constructed and discussed. Indications for first-order and second-order shape phase transitions can be obtained from binding energies and from critical exponents, respectively.

  2. The elliptic quantum algebra Uq,p(sl-hatN) and its vertex operators

    International Nuclear Information System (INIS)

    Chang Wenjing; Ding Xiangmao

    2009-01-01

    We construct a realization of the elliptic quantum algebra U q,p (sl-hat N ) for any given level k in terms of free boson fields and their twisted partners. It can be considered as the elliptic deformation of the Wakimoto realization of the quantum affine algebra U q (sl-hat N ). We also construct a family of screening currents, which commute with the currents of U q,p (sl-hat N ) up to total q-differences. And we give explicit twisted expressions for the type I and type II vertex operators of U q,p (sl-hat N ) by twisting the known results of the type I vertex operators of the quantum affine algebra U q (sl-hat N ) and the new results of the type II vertex operators of U q (sl-hat N ) we obtained in this paper.

  3. UMTRA project water sampling and analysis plan, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1994-04-01

    The Mexican Hat, Utah, Uranium Mill Tailings Remedial Action (UMTRA) Project site is a former uranium mill that is undergoing surface remediation in the form of on-site tailings stabilization. Contaminated surface materials from the Monument Valley, Arizona, UMTRA Project site have been transported to the Mexican Hat site and are being consolidated with the Mexican Hat tailings. The scheduled completion of the tailings disposal cell is August 1995. Water is found in two geologic units at the site: the Halgaito Shale Formation and the Honaker Trail Formation. The tailings rest on the Halgaito Shale, and water contained in that unit is a result of milling activities and, to a lesser extent, water released from the tailings from compaction during remedial action construction of the disposal cell. Water in the Halgaito Shale flows through fractures and discharges at seeps along nearby arroyos. Flow from the seeps will diminish as water drains from the unit. Ground water in the lower unit, the Honaker Trail Formation, is protected from contamination by an upward hydraulic gradient. There are no nearby water supply wells because of widespread poor background ground water quality and quantity, and the San Juan River shows no impacts from the site. This water sampling and analysis plan (WSAP) recommends sampling six seeps and one upgradient monitor well compared in the Honaker Trail Formation. Samples will be taken in April 1994 (representative of high group water levels) and September 1994 (representative of low ground water levels). Analyses will be performed on filtered samples for plume indicator parameters

  4. Wie viel Kapazität hat ein Mobilfunknetz?

    Science.gov (United States)

    Eisenblätter, Andreas; Geerdes, Hans-Florian

    Wer hat das noch nicht erlebt? Der Akku ist aufgeladen und reichlich Guthaben vorhanden, doch das Telefonieren mit dem Handy klappt trotzdem nicht. Meist liegt das daran, dass man sich in einem Funkloch befindet. Aber manchmal ist auch das Netz überlastet. Anders gesagt: das Funknetz des Mobilfunkanbieters, das viele Antennen auf Hausdächern oder Masten umfasst, bietet entweder nicht genügend Abdeckung oder nicht genügend Kapazität. Genau das will der Anbieter natürlich vermeiden. Mathematik hilft, diese Herausforderungen mit einer guten Planung des Mobilfunknetzes zu bewältigen.

  5. Validation of buoyancy driven spectral tensor model using HATS data

    DEFF Research Database (Denmark)

    Chougule, A.; Mann, Jakob; Kelly, Mark C.

    2016-01-01

    We present a homogeneous spectral tensor model for wind velocity and temperature fluctuations, driven by mean vertical shear and mean temperature gradient. Results from the model, including one-dimensional velocity and temperature spectra and the associated co-spectra, are shown in this paper....... The model also reproduces two-point statistics, such as coherence and phases, via cross-spectra between two points separated in space. Model results are compared with observations from the Horizontal Array Turbulence Study (HATS) field program (Horst et al. 2004). The spectral velocity tensor in the model...

  6. USING SIX THINKING HATS AS A TOOL FOR LATERAL THINKING IN ORGANIZATIONAL PROBLEM SOLVING

    OpenAIRE

    Dr. P. S. Aithal; Dr. P. M. Suresh Kumar

    2016-01-01

    Six thinking hats is recently introduced technique which outlines different thinking styles required by an individual while analysing a given problem in an effective way. The technique correlates different thinking styles used in a systematic problem-solving procedure with different coloured hats. Alternately, by conceptualizing each type of hat, the person focuses on the style of thinking associated with each colour so that the problem can be analysed from different angles and frame of refer...

  7. HAT-P-16b: A Bayesian Atmospheric Retrieval

    Science.gov (United States)

    McIntyre, Kathleen; Harrington, Joseph; Blecic, Jasmina; Cubillos, Patricio; Challener, Ryan; Bakos, Gaspar

    2017-10-01

    HAT-P-16b is a hot (equilibrium temperature 1626 ± 40 K, assuming zero Bond albedo and efficient energy redistribution), 4.19 ± 0.09 Jupiter-mass exoplanet orbiting an F8 star every 2.775960 ± 0.000003 days (Buchhave et al 2010). We observed two secondary eclipses of HAT-P-16b using the 3.6 μm and 4.5 μm channels of the Spitzer Space Telescope's Infrared Array Camera (program ID 60003). We applied our Photometry for Orbits, Eclipses, and Transits (POET) code to produce normalized eclipse light curves, and our Bayesian Atmospheric Radiative Transfer (BART) code to constrain the temperature-pressure profiles and atmospheric molecular abundances of the planet. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

  8. Programmable temperature regulator of VAO-1 furnace

    International Nuclear Information System (INIS)

    Zahalka, F.

    1979-01-01

    A programmable temperature controller is described for a furnace for high-level waste processing. Furnace temperature is controlled by a program compiled from a combination of 3 parts with different linear increments or decrements of time dependent temperature and 2 parts with isothermal control for over a preset period. The equipment consists essentially of a programming unit, a programmed digital-to-analog converter and a power unit. The design is described in detail and its specifications are given. The maximum operating temperature of 1500 degC may be reached in the furnace charge section. (B.S.)

  9. Giant Paperclip Necklaces, Soup-Can Rings and Cherry-Pie Hats

    Science.gov (United States)

    Winters, Laurel A.

    2011-01-01

    In this article, the author describes an art project inspired by the wearable sculpture art created by artist Marjorie Schick. Students used wallpaper paste and newspapers to create papier-mache for a mountain hat, a cherry-pie mask/hat, a "dress" shoe and a Cubistic mask. Cardboard was used in many of these things, in addition to being used as…

  10. Home Automated Telemanagement (HAT System to Facilitate Self-Care of Patients with Chronic Diseases

    Directory of Open Access Journals (Sweden)

    Joseph Finkelstein

    2003-06-01

    Full Text Available Successful patient self-management requires a multidisciplinary approach that includes regular patient assessment, disease-specific education, control of medication adherence, implementation of health behavior change models and social support. Existing systems for computer-assisted disease management do not provide this multidisciplinary patient support and do not address treatment compliance issues. We developed the Home Automated Telemanagement (HAT system for patients with different chronic health conditions to facilitate their self-care. The HAT system consists of a home unit, HAT server, and clinician units. Patients at home use a palmtop or a laptop connected with a disease monitor on a regular basis. Each HAT session consists of self-testing, feedback, and educational components. The self-reported symptom data and objective results obtained from disease-specific sensors are automatically sent from patient homes to the HAT server in the hospital. Any web-enabled device can serve as a clinician unit to review patient results. The HAT system monitors self-testing results and patient compliance. The HAT system has been implemented and tested in patients receiving anticoagulation therapy, patients with asthma, COPD and other health conditions. Evaluation results indicated high level of acceptance of the HAT system by the patients and that the system has a positive impact on main clinical outcomes and patient satisfaction with medical care.

  11. Cross-section crushing behaviour of hat-sections (Part II: Analytical modelling)

    NARCIS (Netherlands)

    Hofmeyer, H.

    2005-01-01

    Hat-sections are often used to experimentally investigate building sheeting subject to a concentrated load and bending. In car doors, hat-sections are used for side-impact protection. Their crushing behaviour can partly be explained by only observing their cross-sectional behaviour [1]. This

  12. WARM SPITZER OBSERVATIONS OF THREE HOT EXOPLANETS: XO-4b, HAT-P-6b, AND HAT-P-8b

    Energy Technology Data Exchange (ETDEWEB)

    Todorov, Kamen O. [Department of Astronomy and Astrophysics, The Pennsylvania State University, University Park, PA 16802 (United States); Deming, Drake [Planetary Systems Laboratory, NASA' s Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Knutson, Heather A. [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Burrows, Adam [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 05844 (United States); Sada, Pedro V. [Department of Physics and Mathematics, University of Monterrey, Monterrey (Mexico); Cowan, Nicolas B. [Department of Physics and Astronomy, Northwestern University, Evanston, IL 60208 (United States); Agol, Eric [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Desert, Jean-Michel; Charbonneau, David [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Fortney, Jonathan J.; Laughlin, Gregory [Department of Astronomy and Astrophysics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States); Langton, Jonathan [Department of Physics, Principia College, Elsah, IL 62028 (United States); Showman, Adam P.; Lewis, Nikole K. [Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721 (United States)

    2012-02-10

    We analyze Warm Spitzer/Infrared Array Camera observations of the secondary eclipses of three planets, XO-4b, HAT-P-6b, and HAT-P-8b. We measure secondary eclipse amplitudes at 3.6 {mu}m and 4.5 {mu}m for each target. XO-4b exhibits a stronger eclipse depth at 4.5 {mu}m than at 3.6 {mu}m, which is consistent with the presence of a temperature inversion. HAT-P-8b shows a stronger eclipse amplitude at 3.6 {mu}m and is best described by models without a temperature inversion. The eclipse depths of HAT-P-6b can be fitted with models with a small or no temperature inversion. We consider our results in the context of a postulated relationship between stellar activity and temperature inversion and a relationship between irradiation level and planet dayside temperature, as discussed by Knutson et al. and Cowan and Agol, respectively. Our results are consistent with these hypotheses, but do not significantly strengthen them. To measure accurate secondary eclipse central phases, we require accurate ephemerides. We obtain primary transit observations and supplement them with publicly available observations to update the orbital ephemerides of the three planets. Based on the secondary eclipse timing, we set upper boundaries for ecos ({omega}) for HAT-P-6b, HAT-P-8b, and XO-4b and find that the values are consistent with circular orbits.

  13. Incidence of Hospital Acquired Thrombosis (HAT) in a Tertiary Care Hospital.

    LENUS (Irish Health Repository)

    Khan, MI

    2017-04-01

    Venous thromboembolism (VTE) is a major cause of preventable morbidity and mortality in hospitalized patients. In spite of guidelines, VTE prophylaxis continues to be underutilised, and hospital acquired thrombosis (HAT) continues to be a problem. This study was conducted to estimate the incidence of HAT in a tertiary referral centre and to examine whether VTE risk assessment and thromboprophylaxis (TP) were implemented. Patients 18 years and above, with a radiologically-confirmed acute VTE during the study period of 15 weeks were included. Acute VTE was diagnosed in 100 patients and HAT was diagnosed in 48. There were 12,024 admissions over the study period, therefore the incidence of HAT was 0.4%. TP was prescribed in only 35% of patients, and 65% did not receive any or appropriate TP. Hospitals without active implementation of a formal risk assessment tool and TP policy are likely to continue to have increased incidence of HAT.

  14. The man who mistook his wife for a hat

    CERN Document Server

    Sacks, Oliver

    2011-01-01

    Oliver Sacks’s The Man Who Mistook His Wife for a Hat tells the stories of individuals afflicted with fantastic perceptual and intellectual aberrations: patients who have lost their memories and with them the greater part of their pasts; who are no longer able to recognize people and common objects; who are stricken with violent tics and grimaces or who shout involuntary obscenities; whose limbs have become alien; who have been dismissed as retarded yet are gifted with uncanny artistic or mathematical talents. If inconceivably strange, these brilliant tales remain, in Dr. Sacks’s splendid and sympathetic telling, deeply human. They are studies of life struggling against incredible adversity, and they enable us to enter the world of the neurologically impaired, to imagine with our hearts what it must be to live and feel as they do. A great healer, Sacks never loses sight of medicine’s ultimate responsibility: “the suffering, afflicted, fighting human subject.”

  15. UMTRA Project Site Observational Work Plan, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1994-09-01

    Surface cleanup activities at the Mexican Hat UMTRA processing site are nearing completion. Ground Water contamination at the Mexican Hat site is a result of uranium milling operations. The extent of residual process water has been identified, and it is limited to the uppermost aquifer in the vicinity of the site. Deeper aquifers are not affected because of an upward hydraulic gradient and the presence of a confining unit (the deeper aquifers are protected by hydrogeologic isolation). The uppermost unit is returning to its pre-milling, mainly unsaturated state. The unit that contains the contaminated water is not a ground water resource because it qualifies as Class III (limited use) based on limited yield. Ground water in the uppermost unit is currently not used and is not anticipated to be used as a ground water resource. The nearby San Juan River and a converted oil exploration well provide all of the water needs for the area. There are no current threats to human health or livestock; and, because the zone of contamination does not represent a ground water resource, none are anticipated in the future. There are, however, seeps where contaminated water is exposed at land surface. The seeps create potential exposure pathways for plants and wildlife. It is not known at this time if there is a risk to the environment. Additional investigations are needed and are described in this document to confirm the presence or absence of potential environmental risks. Additional hydrogeologic investigations are not required. The proposed ground water compliance strategy for the site is no remediation, because the ground water in the uppermost aquifer (which is also the zone of contamination) qualifies for supplemental standards based on Class III, limited yield, and because there are no threats to human health. Domestic and agricultural water is pumped from a deeper aquifer that is isolated from the contaminated zone

  16. Monitoring of BTX by passive sampling in Hat Yai

    Directory of Open Access Journals (Sweden)

    Proespichaya Kanatharana

    2004-02-01

    Full Text Available Laboratory-built passive samplers were used for monitoring of trace benzene, toluene and xylene (BTX in Hat Yai from 28 July to 12 August, 2003. Sampler bottles contained activated Tenax TA 60/80 meshand a lab-built thermal well were developed and evaluated for the sampling and analysis of BTX. The sampling was carried out for two weeks before the passive samplers were thermally desorbed, trapped ina sampling loop by a laboratory built purge and trap system and analysed by gas chromatography (GC equipped with a flame ionization detector. After optimization and calibration, the developed method showed high selectivity, a good sensitivity with detection limits for BTX of 0.8, 1.1 and 13.0 µg/m3 respectively and an acceptable precision. Ambient BTX measurements were conducted at many monitoring site i.e. hot spots (high exposure, residential areas/work places (common exposure and park (low exposure. The concentration at hot spots range from 3.2 to 5.4 µg/m3 for benzene, 38.0 to 80.3 µg/m3 for toluene and 29.7 to 66.7 µg/m3 for xylene.The low BTX were found at the city periphery (Tesco-Lotus billboard sampling stations, roof level and in Hat Yai Municipal Park but no absolute background concentration could be defined. The monitoring results showed that at higher level from the street surface, the level of BTX tended to decrease and the BTX pollution built up along a street canyon (Sanehanuson Road according to the wind direction. The highest BTX were found at the underground parking, 23.5 725.1 and 267.9 µg/m3 respectively where both WHO guideline for Benzene (16.3 µg/m3 and Toluene (260 µg/m3 were exceeded.

  17. 30 CFR 75.1720-1 - Distinctively colored hard hats, or hard caps; identification for newly employed, inexperienced...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Distinctively colored hard hats, or hard caps... STANDARDS-UNDERGROUND COAL MINES Miscellaneous § 75.1720-1 Distinctively colored hard hats, or hard caps; identification for newly employed, inexperienced miners. Hard hats or hard caps distinctively different in color...

  18. 30 CFR 77.1710-1 - Distinctively colored hard hats or hard caps; identification for newly employed, inexperienced...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Distinctively colored hard hats or hard caps... Distinctively colored hard hats or hard caps; identification for newly employed, inexperienced miners. Hard hats or hard caps distinctively different in color from those worn by experienced miners shall be worn at...

  19. HAT-P-11: Discovery of a Second Planet and a Clue to Understanding Exoplanet Obliquities

    Science.gov (United States)

    Yee, Samuel W.; Petigura, Erik A.; Fulton, Benjamin J.; Knutson, Heather A.; Batygin, Konstantin; Bakos, Gáspár Á.; Hartman, Joel D.; Hirsch, Lea A.; Howard, Andrew W.; Isaacson, Howard; Kosiarek, Molly R.; Sinukoff, Evan; Weiss, Lauren M.

    2018-06-01

    HAT-P-11 is a mid-K dwarf that hosts one of the first Neptune-sized planets found outside the solar system. The orbit of HAT-P-11b is misaligned with the star’s spin—one of the few known cases of a misaligned planet orbiting a star less massive than the Sun. We find an additional planet in the system based on a decade of precision radial velocity (RV) measurements from Keck/High Resolution Echelle Spectrometer. HAT-P-11c is similar to Jupiter in its mass ({M}P\\sin i=1.6+/- 0.1 M J ) and orbital period (P={9.3}-0.5+1.0 year), but has a much more eccentric orbit (e = 0.60 ± 0.03). In our joint modeling of RV and stellar activity, we found an activity-induced RV signal of ∼7 {{m}} {{{s}}}-1, consistent with other active K dwarfs, but significantly smaller than the 31 {{m}} {{{s}}}-1 reflex motion due to HAT-P-11c. We investigated the dynamical coupling between HAT-P-11b and c as a possible explanation for HAT-P-11b’s misaligned orbit, finding that planet–planet Kozai interactions cannot tilt planet b’s orbit due to general relativistic precession; however, nodal precession operating on million year timescales is a viable mechanism to explain HAT-P-11b’s high obliquity. This leaves open the question of why HAT-P-11c may have such a tilted orbit. At a distance of 38 pc, the HAT-P-11 system offers rich opportunities for further exoplanet characterization through astrometry and direct imaging.

  20. Nipple Reduction With the Chullo-Hat Technique.

    Science.gov (United States)

    Sim, Hyung-Bo; Sun, Sang-Hoon

    2015-08-01

    Although various techniques of nipple reduction have been described in the literature, many are difficult to design or have unreliable outcomes. For men, as well as women who do not plan to breastfeed, it is not necessary to apply a complicated technique that protects the lactiferous ducts. The authors introduce a simple technique for nipple reduction that has achieved consistent, reproducible results. The desired nipple length is marked, and a chullo-hat excision pattern is drawn. After infiltration of a local anesthetic solution around the nipple, excision of the excess nipple tissue is performed, comprising 2 triangular flaps. The remaining 2 pillars are approximated with 5-0 Nylon simple interrupted sutures. However, the wound is not completely closed in the central area of the nipple, which promotes the drainage of discharge. Fifty-three women (106 nipples) underwent this surgery between December 2009 and December 2013. The follow-up period ranged from 6 months to 2 years (mean, 10 months). No major complications occurred, and the scars were very inconspicuous. The postoperative appearance of nipples was consistently similar in size and shape. This simple technique was safe and effective in nipples of different sizes. The results were reliable and consistent with expectations. Although this study included only women, the authors believe that outcomes would be successful in men as well. 4 Therapeutic. © 2015 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com.

  1. Application of Human-Autonomy Teaming (HAT) Patterns to Reduce Crew Operations (RCO)

    Science.gov (United States)

    Shively, R. Jay; Brandt, Summer L.; Lachter, Joel; Matessa, Mike; Sadler, Garrett; Battiste, Henri

    2016-01-01

    Unmanned aerial systems, robotics, advanced cockpits, and air traffic management are all examples of domains that are seeing dramatic increases in automation. While automation may take on some tasks previously performed by humans, humans will still be required, for the foreseeable future, to remain in the system. The collaboration with humans and these increasingly autonomous systems will begin to resemble cooperation between teammates, rather than simple task allocation. It is critical to understand this human-autonomy teaming (HAT) to optimize these systems in the future. One methodology to understand HAT is by identifying recurring patterns of HAT that have similar characteristics and solutions. This paper applies a methodology for identifying HAT patterns to an advanced cockpit project.

  2. Application of Human-Autonomy Teaming (HAT) Patterns to Reduced Crew Operations (RCO)

    Science.gov (United States)

    Shively, R. Jay; Brandt, Summer L.; Lachter, Joel; Matessa, Mike; Sadler, Garrett; Battiste, Henri

    2016-01-01

    As part of the Air Force - NASA Bi-Annual Research Council Meeting, slides will be presented on recent Reduced Crew Operations (RCO) work. Unmanned aerial systems, robotics, advanced cockpits, and air traffic management are all examples of domains that are seeing dramatic increases in automation. While automation may take on some tasks previously performed by humans, humans will still be required, for the foreseeable future, to remain in the system. The collaboration with humans and these increasingly autonomous systems will begin to resemble cooperation between teammates, rather than simple task allocation. It is critical to understand this human-autonomy teaming (HAT) to optimize these systems in the future. One methodology to understand HAT is by identifying recurring patterns of HAT that have similar characteristics and solutions. A methodology for identifying HAT patterns to an advanced cockpit project is discussed.

  3. Maximizing prosthetic valve size with the Top Hat supra-annular aortic valve

    DEFF Research Database (Denmark)

    Aagaard, Jan; Geha, Alexander S.

    2007-01-01

    BACKGROUND AND AIM OF THE STUDY: The CarboMedics Top Hat supra-annular aortic valve allows a one-size (and often two-size) increase over the standard intra-annular valve. This advantage should minimize the risk of patient-prosthesis mismatch, where the effective prosthetic valve orifice area....... This study evaluates the authors' clinical experience with Top Hat supra-annular aortic valve size selection, and the technical aspects of implantation. METHODS: Between January 1999 and October 2005, a total of 251 consecutive patients underwent 252 aortic valve replacements with Top Hat supra...... required unplanned coronary bypass, and 30-day mortality was 2.0% (5/251), indicating a good safety profile for the valves implanted in this series. CONCLUSION: The general distribution of implant sizes in the US indicates that cardiac surgeons may be under-sizing the Top Hat supra-annular aortic valve...

  4. Epigenetic control of learning and memory in Drosophila by Tip60 HAT action.

    Science.gov (United States)

    Xu, Songjun; Wilf, Rona; Menon, Trisha; Panikker, Priyalakshmi; Sarthi, Jessica; Elefant, Felice

    2014-12-01

    Disruption of epigenetic gene control mechanisms in the brain causes significant cognitive impairment that is a debilitating hallmark of most neurodegenerative disorders, including Alzheimer's disease (AD). Histone acetylation is one of the best characterized of these epigenetic mechanisms that is critical for regulating learning- and memory- associated gene expression profiles, yet the specific histone acetyltransferases (HATs) that mediate these effects have yet to be fully characterized. Here, we investigate an epigenetic role for the HAT Tip60 in learning and memory formation using the Drosophila CNS mushroom body (MB) as a well-characterized cognition model. We show that Tip60 is endogenously expressed in the Kenyon cells, the intrinsic neurons of the MB, and in the MB axonal lobes. Targeted loss of Tip60 HAT activity in the MB causes thinner and shorter axonal lobes while increasing Tip60 HAT levels cause no morphological defects. Functional consequences of both loss and gain of Tip60 HAT levels in the MB are evidenced by defects in immediate-recall memory. Our ChIP-Seq analysis reveals that Tip60 target genes are enriched for functions in cognitive processes, and, accordingly, key genes representing these pathways are misregulated in the Tip60 HAT mutant fly brain. Remarkably, we find that both learning and immediate-recall memory deficits that occur under AD-associated, amyloid precursor protein (APP)-induced neurodegenerative conditions can be effectively rescued by increasing Tip60 HAT levels specifically in the MB. Together, our findings uncover an epigenetic transcriptional regulatory role for Tip60 in cognitive function and highlight the potential of HAT activators as a therapeutic option for neurodegenerative disorders. Copyright © 2014 by the Genetics Society of America.

  5. Phase II, Title I engineering assessment of inactive uranium mill tailings, Mexican Hat site, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1977-01-01

    An engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at the Mexican Hat millsite in Utah is presented. Topographic maps, data on core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and other radium-contaminated materials, the evaluation of resulting radiation exposures of individuals residing nearby, the investigation of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions are presented. Radon gas release from the 2,200,000 tons of tailings on the site constitutes the most significant environmental impact. T he six alternative actions presented are directed towards restricting access to the site, returning the windblown tailings to the piles and stabilizing the piles with cover material, and consolidating the two piles into one pile and stabilizing it with cover material. Fencing around the site or the tailings and the decontamination of mill buildings is included in all options. Costs of the options range from $370,000 to $4,390,000

  6. Tip off the HAT- Epigenetic control of learning and memory by Drosophila Tip60.

    Science.gov (United States)

    Xu, Songjun; Elefant, Felice

    2015-01-01

    Disruption of epigenetic gene control mechanisms involving histone acetylation in the brain causes cognitive impairment, a debilitating hallmark of most neurodegenerative disorders. Histone acetylation regulates cognitive gene expression via chromatin packaging control in neurons. Unfortunately, the histone acetyltransferases (HATs) that generate such neural epigenetic signatures and their mechanisms of action remain unclear. Our recent findings provide insight into this question by demonstrating that Tip60 HAT action is critical for morphology and function of the mushroom body (MB), the learning and memory center in the Drosophila brain. We show that Tip60 is robustly produced in MB Kenyon cells and extending axonal lobes and that targeted MB Tip60 HAT loss results in axonal outgrowth disruption. Functional consequences of loss and gain of Tip60 HAT levels in the MB are evidenced by defects in memory. Tip60 ChIP-Seq analysis reveals enrichment for genes that function in cognitive processes and accordingly, key genes representing these pathways are misregulated in the Tip60 HAT mutant fly brain. Remarkably, increasing levels of Tip60 in the MB rescues learning and memory deficits resulting from Alzheimer's disease associated amyloid precursor protein (APP) induced neurodegeneration. Our studies highlight the potential of HAT activators as a therapeutic option for cognitive disorders.

  7. Supplement to the UMTRA Project water sampling and analysis plan, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1995-09-01

    This water sampling and analysis plan (WSAP) supplement supports the regulatory and technical basis for water sampling at the Mexican Hat, Utah, Uranium Mill Tailings Remedial Action (UMTRA) Project site, as defined in the 1994 WSAP document for Mexican Hat (DOE, 1994). Further, the supplement serves to confirm our present understanding of the site relative to the hydrogeology and contaminant distribution as well as our intention to continue to use the sampling strategy as presented in the 1994 WSAP document for Mexican Hat. Ground water and surface water monitoring activities are derived from the US Environmental Protection Agency regulations in 40 CFR Part 192 (1991) and 60 FR 2854 (1995). Sampling procedures are guided by the UMTRA Project standard operating procedures (JEG, n.d.), the Technical Approach Document (DOE, 1989), and the most effective technical approach for the site. Additional site-specific documents relevant to the Mexican Hat site are the Mexican Hat Long-Term Surveillance Plan (currently in progress), and the Mexican Hat Site Observational Work Plan (currently in progress)

  8. HATS-50b through HATS-53b: Four Transiting Hot Jupiters Orbiting G-type Stars Discovered by the HATSouth Survey

    Science.gov (United States)

    Henning, Th.; Mancini, L.; Sarkis, P.; Bakos, G. Á.; Hartman, J. D.; Bayliss, D.; Bento, J.; Bhatti, W.; Brahm, R.; Ciceri, S.; Csubry, Z.; de Val-Borro, M.; Espinoza, N.; Fulton, B. J.; Howard, A. W.; Isaacson, H. T.; Jordán, A.; Marcy, G. W.; Penev, K.; Rabus, M.; Suc, V.; Tan, T. G.; Tinney, C. G.; Wright, D. J.; Zhou, G.; Durkan, S.; Lazar, J.; Papp, I.; Sari, P.

    2018-02-01

    We report the discovery of four close-in transiting exoplanets (HATS-50b through HATS-53b), discovered using the HATSouth three-continent network of homogeneous and automated telescopes. These new exoplanets belong to the class of hot Jupiters and orbit G-type dwarf stars, with brightness in the range V = 12.5–14.0 mag. While HATS-53 has many physical characteristics similar to the Sun, the other three stars appear to be metal-rich ([{Fe}/{{H}}]=0.2{--}0.3), larger, and more massive. Three of the new exoplanets, namely HATS-50b, HATS-51b, and HATS-53b, have low density (HATS-50b: 0.39+/- 0.10 {M}{{J}}, 1.130+/- 0.075 {R}{{J}}; HATS-51b: 0.768+/- 0.045 {M}{{J}}, 1.41+/- 0.19 {R}{{J}}; HATS-53b: 0.595+/- 0.089 {M}{{J}}, 1.340+/- 0.056 {R}{{J}}) and similar orbital periods (3.8297 days, 3.3489 days, 3.8538 days, respectively). Instead, HATS-52b is more dense (mass 2.24+/- 0.15 {M}{{J}} and radius 1.382+/- 0.086 {R}{{J}}) and has a shorter orbital period (1.3667 days). It also receives an intensive radiation from its parent star and, consequently, presents a high equilibrium temperature ({T}{eq}=1834+/- 73 K). HATS-50 shows a marginal additional transit feature consistent with an ultra-short-period hot super Neptune (upper mass limit 0.16 {M}{{J}}), which will be able to be confirmed with TESS photometry. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. Based in part on observations made with the ESO 3.6 m, the NTT, the MPG 2.2 m and Euler 1.2 m Telescopes at the ESO Observatory in

  9. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah: Appendices C--E. Final report

    International Nuclear Information System (INIS)

    1993-02-01

    This document provides appendices C, D, and E this Remedial Action Plan (RAP) which is a revision of the original Mexican Hat Remedial Action Plan and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. Appendix C provide the Radiological Support Plan, Appendix D provides the Site Characterization, and Appendix E provides the Water Resources Protection Strategy

  10. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah: Appendices C--E. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-02-01

    This document provides appendices C, D, and E this Remedial Action Plan (RAP) which is a revision of the original Mexican Hat Remedial Action Plan and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. Appendix C provide the Radiological Support Plan, Appendix D provides the Site Characterization, and Appendix E provides the Water Resources Protection Strategy.

  11. The GAPS programme with HARPS-N at TNG. XVI. Measurement of the Rossiter-McLaughlin effect of transiting planetary systems HAT-P-3, HAT-P-12, HAT-P-22, WASP-39, and WASP-60

    Science.gov (United States)

    Mancini, L.; Esposito, M.; Covino, E.; Southworth, J.; Biazzo, K.; Bruni, I.; Ciceri, S.; Evans, D.; Lanza, A. F.; Poretti, E.; Sarkis, P.; Smith, A. M. S.; Brogi, M.; Affer, L.; Benatti, S.; Bignamini, A.; Boccato, C.; Bonomo, A. S.; Borsa, F.; Carleo, I.; Claudi, R.; Cosentino, R.; Damasso, M.; Desidera, S.; Giacobbe, P.; González-Álvarez, E.; Gratton, R.; Harutyunyan, A.; Leto, G.; Maggio, A.; Malavolta, L.; Maldonado, J.; Martinez-Fiorenzano, A.; Masiero, S.; Micela, G.; Molinari, E.; Nascimbeni, V.; Pagano, I.; Pedani, M.; Piotto, G.; Rainer, M.; Scandariato, G.; Smareglia, R.; Sozzetti, A.; Andreuzzi, G.; Henning, Th.

    2018-05-01

    Context. The measurement of the orbital obliquity of hot Jupiters with different physical characteristics can provide clues to the mechanisms of migration and orbital evolution of this particular class of giant exoplanets. Aims: We aim to derive the degree of alignment between planetary orbit and stellar spin angular momentum vectors and look for possible links with other orbital and fundamental physical parameters of the star-planet system. We focus on the characterisation of five transiting planetary systems (HAT-P-3, HAT-P-12, HAT-P-22, WASP-39, and WASP-60) and the determination of their sky-projected planet orbital obliquity through the measurement of the Rossiter-McLaughlin effect. Methods: We used HARPS-N high-precision radial velocity measurements, gathered during transit events, to measure the Rossiter-McLaughlin effect in the target systems and determine the sky-projected angle between the planetary orbital plane and stellar equator. The characterisation of stellar atmospheric parameters was performed by exploiting the HARPS-N spectra, using line equivalent width ratios and spectral synthesis methods. Photometric parameters of the five transiting exoplanets were re-analysed through 17 new light curves, obtained with an array of medium-class telescopes, and other light curves from the literature. Survey-time-series photometric data were analysed for determining the rotation periods of the five stars and their spin inclination. Results: From the analysis of the Rossiter-McLaughlin effect we derived a sky-projected obliquity of λ = 21.2° ± 8.7°, λ = -54°-13°+41°, λ = -2.1° ± 3.0°, λ = 0° ± 11°, and λ = -129° ± 17° for HAT-P-3 b, HAT-P-12 b, HAT-P-22 b, WASP-39 b, and WASP-60 b, respectively. The latter value indicates that WASP-60 b is moving on a retrograde orbit. These values represent the first measurements of λ for the five exoplanetary systems under study. The stellar activity of HAT-P-22 indicates a rotation period of 28.7 ± 0

  12. HAT-P-10b: A LIGHT AND MODERATELY HOT JUPITER TRANSITING A K DWARF

    International Nuclear Information System (INIS)

    Bakos, G. A.; Pal, A.; Torres, G.; Sipocz, B.; Latham, D. W.; Noyes, R. W.; Hartman, J.; Esquerdo, G. A.; Sasselov, D. D.; Kovacs, Gabor; Stefanik, R. P.; Kovacs, Geza; Fischer, D. A.; Johnson, J. A.; Marcy, G. W.; Howard, A. W.; Butler, R. P.; Lazar, J.; Papp, I.; Sari, P.

    2009-01-01

    We report on the discovery of HAT-P-10b, one of the lowest mass (0.487 ± 0.018 M J ) transiting extrasolar planets (TEPs) discovered to date by transit searches. HAT-P-10b orbits the moderately bright V = 11.89 K dwarf GSC 02340-01714, with a period P = 3.7224747 ± 0.0000065 days, transit epoch T c = 2454759.68683 ± 0.00016 (BJD), and duration 0.1090 ± 0.0008 days. HAT-P-10b has a radius of 1.005 +0.032 -0.027 R J yielding a mean density of 0.594 ± 0.052 g cm -3 . Comparing these observations with recent theoretical models we find that HAT-P-10b is consistent with a ∼4.5 Gyr, almost pure hydrogen and helium gas giant planet with a 10 M + core. With an equilibrium temperature of T eq = 1020 ± 17 K, HAT-P-10b is one of the coldest TEPs. Curiously, its Safronov number θ = 0.053 ± 0.002 falls close to the dividing line between the two suggested TEP populations.

  13. Estimating q-hat in Quenched Lattice SU(2) Gauge Theory

    International Nuclear Information System (INIS)

    Majumder, Abhijit

    2013-01-01

    The propagation of a virtual quark in a thermal medium is considered. The non-perturbative jet transport coefficient q -hat is estimated in quark less SU(2) lattice gauge theory. The light like correlator which defines q -hat , defined in the regime where the jet has small virtuality compared to its energy, is analytically related to a series of local operators in the deep Euclidean region, where the jet's virtuality is of the same order as its energy. It is demonstrated that in this region, for temperatures in the range of T=400–600 MeV, and for jet energies above 20 GeV, the leading term in the series is dominant over the next-to-leading term and thus yields an estimate of the value of q -hat . In these proceedings we discuss the details of the numerical calculation

  14. Targeting Specific HATs for Neurodegenerative Disease Treatment: Translating Basic Biology to Therapeutic Possibilities

    Directory of Open Access Journals (Sweden)

    Sheila K. Pirooznia

    2013-03-01

    Full Text Available Dynamic epigenetic regulation of neurons is emerging as a fundamental mechanism by which neurons adapt their transcriptional responses to specific developmental and environmental cues. While defects within the neural epigenome have traditionally been studied in the context of early developmental and heritable cognitive disorders, recent studies point to aberrant histone acetylation status as a key mechanism underlying acquired inappropriate alterations of genome structure and function in post-mitotic neurons during the aging process. Indeed, it is becoming increasingly evident that chromatin acetylation status can be impaired during the lifetime of neurons through mechanisms related to loss of function of histone acetyltransferase (HATs activity. Several HATs have been shown to participate in vital neuronal functions such as regulation of neuronal plasticity and memory formation. As such, dysregulation of such HATs has been implicated in the pathogenesis associated with age-associated neurodegenerative diseases and cognitive decline. In order to counteract the loss of HAT function in neurodegenerative diseases, the current therapeutic strategies involve the use of small molecules called histone deacetylase (HDAC inhibitors that antagonize HDAC activity and thus enhance acetylation levels. Although this strategy has displayed promising therapeutic effects, currently used HDAC inhibitors lack target specificity, raising concerns about their applicability. With rapidly evolving literature on HATs and their respective functions in mediating neuronal survival and higher order brain function such as learning and memory, modulating the function of specific HATs holds new promises as a therapeutic tool in neurodegenerative diseases. In this review, we focus on the recent progress in research regarding epigenetic histone acetylation mechanisms underlying neuronal activity and cognitive function. We discuss the current understanding of specific HDACs and

  15. Flexural fatigue life prediction of closed hat-section using materially nonlinear axial fatigue characteristics

    Science.gov (United States)

    Razzaq, Zia

    1989-01-01

    Straight or curved hat-section members are often used as structural stiffeners in aircraft. For instance, they are employed as stiffeners for the dorsal skin as well as in the aerial refueling adjacent area structure in F-106 aircraft. The flanges of the hat-section are connected to the aircraft skin. Thus, the portion of the skin closing the hat-section interacts with the section itself when resisting the stresses due to service loads. The flexural fatigue life of such a closed section is estimated using materially nonlinear axial fatigue characteristics. It should be recognized that when a structural shape is subjected to bending, the fatigue life at the neutral axis is infinity since the normal stresses are zero at that location. Conversely, the fatigue life at the extreme fibers where the normal bending stresses are maximum can be expected to be finite. Thus, different fatigue life estimates can be visualized at various distances from the neural axis. The problem becomes compounded further when significant portions away from the neutral axis are stressed into plastic range. A theoretical analysis of the closed hat-section subjected to flexural cyclic loading is first conducted. The axial fatigue characteristics together with the related axial fatigue life formula and its inverted form given by Manson and Muralidharan are adopted for an aluminum alloy used in aircraft construction. A closed-form expression for predicting the flexural fatigue life is then derived for the closed hat-section including materially nonlinear action. A computer program is written to conduct a study of the variables such as the thicknesses of the hat-section and the skin, and the type of alloy used. The study has provided a fundamental understanding of the flexural fatigue life characteristics of a practical structural component used in aircraft when materially nonlinear action is present.

  16. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1993-02-01

    This document is a revision of the original Mexiacan Hat Remedial Action Plan (RAP) and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. This RAP has been developed to serve a two-fold purpose. It presents the activities proposed by the Department of Energy (DOE) to accomplish long-term stabilization and control of the residual radioactive materials (RRM) from Monument Valley, Arizona, and Mexican Hat, Utah, at the Mexican Hat disposal site. It also serves to document the concurrence of both the Navajo Nation and the Nuclear Regulatory Commission (NRC) in the remedial action. This agreement, upon execution by DOE and the Navajo Nation and concurrence by the NRC, becomes Appendix B of the Cooperative Agreement. This document has been structured to provide a comprehensive understanding of the remedial action proposed for the Monument Valley and Mexican Hat sites. It includes specific design and construction requirements for the remedial action. Pertinent information and data are included with reference given to the supporting documents. Section 2.0 presents the EPA standards, including a discussion of their objectives. Section 3. 0 summarizes the present site characteristics and provides a definition of site-specific problems. Section 4.0 is the site design for the proposed action. Section 5.0 presents the water resources protection strategy. Section 6.0 summarizes the plan for ensuring health and safety protection for the surrounding community and the on- site workers. Section 7.0 lists the responsibilities of the project participants. Section 8.0 describes the features of the long-term surveillance and maintenance plan

  17. Virtual Screening of Phytochemicals to Novel Target (HAT) Rtt109 in Pneumocystis Jirovecii using Bioinformatics Tools.

    Science.gov (United States)

    Sugumar, Ramya; Adithavarman, Abhinand Ponneri; Dakshinamoorthi, Anusha; David, Darling Chellathai; Ragunath, Padmavathi Kannan

    2016-03-01

    Pneumocystis jirovecii is a fungus that causes Pneumocystis pneumonia in HIV and other immunosuppressed patients. Treatment of Pneumocystis pneumonia with the currently available antifungals is challenging and associated with considerable adverse effects. There is a need to develop drugs against novel targets with minimal human toxicities. Histone Acetyl Transferase (HAT) Rtt109 is a potential therapeutic target in Pneumocystis jirovecii species. HAT is linked to transcription and is required to acetylate conserved lysine residues on histone proteins by transferring an acetyl group from acetyl CoA to form e-N-acetyl lysine. Therefore, inhibitors of HAT can be useful therapeutic options in Pneumocystis pneumonia. To screen phytochemicals against (HAT) Rtt109 using bioinformatics tool. The tertiary structure of Pneumocystis jirovecii (HAT) Rtt109 was modeled by Homology Modeling. The ideal template for modeling was obtained by performing Psi BLAST of the protein sequence. Rtt109-AcCoA/Vps75 protein from Saccharomyces cerevisiae (PDB structure 3Q35) was chosen as the template. The target protein was modeled using Swiss Modeler and validated using Ramachandran plot and Errat 2. Comprehensive text mining was performed to identify phytochemical compounds with antipneumonia and fungicidal properties and these compounds were filtered based on Lipinski's Rule of 5. The chosen compounds were subjected to virtual screening against the target protein (HAT) Rtt109 using Molegro Virtual Docker 4.5. Osiris Property Explorer and Open Tox Server were used to predict ADME-T properties of the chosen phytochemicals. Tertiary structure model of HAT Rtt 109 had a ProSA score of -6.57 and Errat 2 score of 87.34. Structure validation analysis by Ramachandran plot for the model revealed 97% of amino acids were in the favoured region. Of all the phytochemicals subjected to virtual screening against the target protein (HAT) Rtt109, baicalin exhibited highest binding affinity towards the

  18. WASP-12b and HAT-P-8b are Members of Triple Star Systems

    Science.gov (United States)

    Bechter, Eric B.; Crepp, Justin R.; Ngo, Henry; Knutson, Heather A.; Batygin, Konstantin; Hinkley, Sasha; Muirhead, Philip S.; Johnson, John Asher; Howard, Andrew W.; Montet, Benjamin T.; Matthews, Christopher T.; Morton, Timothy D.

    2014-06-01

    We present high spatial resolution images that demonstrate that WASP-12b and HAT-P-8b orbit the primary stars of hierarchical triple star systems. In each case, two distant companions with colors and brightnesses consistent with M dwarfs co-orbit the hot Jupiter planet host as well as one another. Our adaptive optics images spatially resolve the secondary around WASP-12, previously identified by Bergfors et al. and Crossfield et al. into two distinct sources separated by 84.3 ± 0.6 mas (21 ± 3 AU). We find that the secondary to HAT-P-8, also identified by Bergfors et al., is in fact composed of two stars separated by 65.3 ± 0.5 mas (15 ± 1 AU). Our follow-up observations demonstrate physical association through common proper motion. HAT-P-8 C has a particularly low mass, which we estimate to be 0.18 ± 0.02 M ⊙ using photometry. Due to their hierarchy, WASP-12 BC and HAT-P-8 BC will enable the first dynamical mass determination for hot Jupiter stellar companions. These previously well studied planet hosts now represent higher-order multi-star systems with potentially complex dynamics, underscoring the importance of diffraction-limited imaging and providing additional context for understanding the migrant population of transiting hot Jupiters.

  19. WASP-12b AND HAT-P-8b are members of triple star systems

    International Nuclear Information System (INIS)

    Bechter, Eric B.; Crepp, Justin R.; Matthews, Christopher T.; Ngo, Henry; Knutson, Heather A.; Batygin, Konstantin; Johnson, John Asher; Hinkley, Sasha; Muirhead, Philip S.; Montet, Benjamin T.; Morton, Timothy D.; Howard, Andrew W.

    2014-01-01

    We present high spatial resolution images that demonstrate that WASP-12b and HAT-P-8b orbit the primary stars of hierarchical triple star systems. In each case, two distant companions with colors and brightnesses consistent with M dwarfs co-orbit the hot Jupiter planet host as well as one another. Our adaptive optics images spatially resolve the secondary around WASP-12, previously identified by Bergfors et al. and Crossfield et al. into two distinct sources separated by 84.3 ± 0.6 mas (21 ± 3 AU). We find that the secondary to HAT-P-8, also identified by Bergfors et al., is in fact composed of two stars separated by 65.3 ± 0.5 mas (15 ± 1 AU). Our follow-up observations demonstrate physical association through common proper motion. HAT-P-8 C has a particularly low mass, which we estimate to be 0.18 ± 0.02 M ☉ using photometry. Due to their hierarchy, WASP-12 BC and HAT-P-8 BC will enable the first dynamical mass determination for hot Jupiter stellar companions. These previously well studied planet hosts now represent higher-order multi-star systems with potentially complex dynamics, underscoring the importance of diffraction-limited imaging and providing additional context for understanding the migrant population of transiting hot Jupiters.

  20. WASP-12b AND HAT-P-8b are members of triple star systems

    Energy Technology Data Exchange (ETDEWEB)

    Bechter, Eric B.; Crepp, Justin R.; Matthews, Christopher T. [Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall, Notre Dame, IN 46556 (United States); Ngo, Henry; Knutson, Heather A.; Batygin, Konstantin; Johnson, John Asher [Department of Planetary Science, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Hinkley, Sasha; Muirhead, Philip S.; Montet, Benjamin T.; Morton, Timothy D. [Department of Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Howard, Andrew W., E-mail: ebechter@nd.edu [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States)

    2014-06-10

    We present high spatial resolution images that demonstrate that WASP-12b and HAT-P-8b orbit the primary stars of hierarchical triple star systems. In each case, two distant companions with colors and brightnesses consistent with M dwarfs co-orbit the hot Jupiter planet host as well as one another. Our adaptive optics images spatially resolve the secondary around WASP-12, previously identified by Bergfors et al. and Crossfield et al. into two distinct sources separated by 84.3 ± 0.6 mas (21 ± 3 AU). We find that the secondary to HAT-P-8, also identified by Bergfors et al., is in fact composed of two stars separated by 65.3 ± 0.5 mas (15 ± 1 AU). Our follow-up observations demonstrate physical association through common proper motion. HAT-P-8 C has a particularly low mass, which we estimate to be 0.18 ± 0.02 M {sub ☉} using photometry. Due to their hierarchy, WASP-12 BC and HAT-P-8 BC will enable the first dynamical mass determination for hot Jupiter stellar companions. These previously well studied planet hosts now represent higher-order multi-star systems with potentially complex dynamics, underscoring the importance of diffraction-limited imaging and providing additional context for understanding the migrant population of transiting hot Jupiters.

  1. Six Thinking Hats and Social Workers' Innovative Competence: An Experimental Study

    Science.gov (United States)

    Azeez, Razaq Olugbenga

    2016-01-01

    Employees, no doubt, are the main force in organizations, and their innovative behaviours are vital for outcome efficacy. Innovative organisations, therefore, need creative employees who generate new ideas for product or process of innovation. This study investigated the effect of six thinking hats creativity technique on innovative competence of…

  2. The TopHat experiment: A balloon-borne instrument for mapping millimeter and submillimeter emission

    DEFF Research Database (Denmark)

    Silverberg, R.F.; Cheng, E.S.; Aguirre, J.E.

    2005-01-01

    The TopHat experiment was designed to measure the anisotropy in the cosmic microwave background radiation on angular scales from 0.degrees 3 to 30 degrees and the thermal emission from both Galactic and extragalactic dust. The balloon-borne instrument had five spectral bands spanning frequencies ...

  3. Planet-induced Stellar Pulsations in HAT-P-2's Eccentric System

    International Nuclear Information System (INIS)

    Wit, Julien de; Lewis, Nikole K.; Knutson, Heather A.; Batygin, Konstantin; Fuller, Jim; Antoci, Victoria; Fulton, Benjamin J.; Laughlin, Gregory; Deming, Drake; Shporer, Avi; Cowan, Nicolas B.; Agol, Eric; Burrows, Adam S.; Fortney, Jonathan J.; Langton, Jonathan; Showman, Adam P.

    2017-01-01

    Extrasolar planets on eccentric short-period orbits provide a laboratory in which to study radiative and tidal interactions between a planet and its host star under extreme forcing conditions. Studying such systems probes how the planet’s atmosphere redistributes the time-varying heat flux from its host and how the host star responds to transient tidal distortion. Here, we report the insights into the planet–star interactions in HAT-P-2's eccentric planetary system gained from the analysis of ∼350 hr of 4.5 μ m observations with the Spitzer Space Telescope . The observations show no sign of orbit-to-orbit variability nor of orbital evolution of the eccentric planetary companion, HAT-P-2 b. The extensive coverage allows us to better differentiate instrumental systematics from the transient heating of HAT-P-2 b’s 4.5 μ m photosphere and yields the detection of stellar pulsations with an amplitude of approximately 40 ppm. These pulsation modes correspond to exact harmonics of the planet’s orbital frequency, indicative of a tidal origin. Transient tidal effects can excite pulsation modes in the envelope of a star, but, to date, such pulsations had only been detected in highly eccentric stellar binaries. Current stellar models are unable to reproduce HAT-P-2's pulsations, suggesting that our understanding of the interactions at play in this system is incomplete.

  4. Planet-induced Stellar Pulsations in HAT-P-2's Eccentric System

    Energy Technology Data Exchange (ETDEWEB)

    Wit, Julien de [Department of Earth, Atmospheric and Planetary Sciences, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139 (United States); Lewis, Nikole K. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Knutson, Heather A.; Batygin, Konstantin [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Fuller, Jim [TAPIR, Walter Burke Institute for Theoretical Physics, Mailcode 350-17, California Institute of Technology, Pasadena, CA 91125 (United States); Antoci, Victoria [Stellar Astrophysics Centre, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, DK-8000 Aarhus C (Denmark); Fulton, Benjamin J. [Institute for Astronomy, University of Hawaii, Honolulu, HI 96822 (United States); Laughlin, Gregory [Department of Astronomy, Yale University, New Haven, CT 06511 (United States); Deming, Drake [Department of Astronomy, University of Maryland at College Park, College Park, MD 20742 (United States); Shporer, Avi [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91009 (United States); Cowan, Nicolas B. [Department of Physics, Department of Earth and Planetary Sciences, McGill University, 3550 rue University, Montreal, QC H3A 2A7 (Canada); Agol, Eric [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States); Burrows, Adam S. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Fortney, Jonathan J. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Langton, Jonathan [Department of Physics, Principia College, Elsah, IL 62028 (United States); Showman, Adam P. [Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721 (United States)

    2017-02-20

    Extrasolar planets on eccentric short-period orbits provide a laboratory in which to study radiative and tidal interactions between a planet and its host star under extreme forcing conditions. Studying such systems probes how the planet’s atmosphere redistributes the time-varying heat flux from its host and how the host star responds to transient tidal distortion. Here, we report the insights into the planet–star interactions in HAT-P-2's eccentric planetary system gained from the analysis of ∼350 hr of 4.5 μ m observations with the Spitzer Space Telescope . The observations show no sign of orbit-to-orbit variability nor of orbital evolution of the eccentric planetary companion, HAT-P-2 b. The extensive coverage allows us to better differentiate instrumental systematics from the transient heating of HAT-P-2 b’s 4.5 μ m photosphere and yields the detection of stellar pulsations with an amplitude of approximately 40 ppm. These pulsation modes correspond to exact harmonics of the planet’s orbital frequency, indicative of a tidal origin. Transient tidal effects can excite pulsation modes in the envelope of a star, but, to date, such pulsations had only been detected in highly eccentric stellar binaries. Current stellar models are unable to reproduce HAT-P-2's pulsations, suggesting that our understanding of the interactions at play in this system is incomplete.

  5. How a hat may affect 3-month-olds' recognition of a face: an eye-tracking study.

    Science.gov (United States)

    Bulf, Hermann; Valenza, Eloisa; Turati, Chiara

    2013-01-01

    Recent studies have shown that infants' face recognition rests on a robust face representation that is resilient to a variety of facial transformations such as rotations in depth, motion, occlusion or deprivation of inner/outer features. Here, we investigated whether 3-month-old infants' ability to represent the invariant aspects of a face is affected by the presence of an external add-on element, i.e. a hat. Using a visual habituation task, three experiments were carried out in which face recognition was investigated by manipulating the presence/absence of a hat during face encoding (i.e. habituation phase) and face recognition (i.e. test phase). An eye-tracker system was used to record the time infants spent looking at face-relevant information compared to the hat. The results showed that infants' face recognition was not affected by the presence of the external element when the type of the hat did not vary between the habituation and test phases, and when both the novel and the familiar face wore the same hat during the test phase (Experiment 1). Infants' ability to recognize the invariant aspects of a face was preserved also when the hat was absent in the habituation phase and the same hat was shown only during the test phase (Experiment 2). Conversely, when the novel face identity competed with a novel hat, the hat triggered the infants' attention, interfering with the recognition process and preventing the infants' preference for the novel face during the test phase (Experiment 3). Findings from the current study shed light on how faces and objects are processed when they are simultaneously presented in the same visual scene, contributing to an understanding of how infants respond to the multiple and composite information available in their surrounding environment.

  6. Potential ground water resources of Hat Yai Basin in Peninsular Thailand by gravity study

    Directory of Open Access Journals (Sweden)

    Warawutti Lohawijarn

    2005-05-01

    Full Text Available Residual gravity anomaly with a minimum of about -140 mm s-2 with approximately NS trend and a limited axial length was observed over Hat Yai Basin in Peninsular Thailand. The modeled Hat Yai basin is about 1 km deep at its deepest, 60 km long and 20 km wide. The porosity of basin sediment and the amount of potential ground water reserves within the basin are estimated to be 39% and 121.7±0.8 km3 respectively, assuming full saturation. Within the topmost 80 m of ground where the present extraction is concentrated, the estimated ground water reserve is 12.5±0.5 km3.

  7. HAT-P-68b: A Transiting Hot Jupiter Around a K5 Dwarf Star

    Science.gov (United States)

    Lindor, Bethlee; Hartman, Joel D.

    2018-01-01

    One of the main goals of the astrophysical society has been to detect sources of life outside of Earth. To aid this search, astronomers have spent the last 2 decades focused on the discovery and characterization of exoplanets. The most effective method for doing so has been transit photometry, wherein we measure the brightness of stars over periods of time. These measurements, or light curves, are later analyzed for dips in brightness caused by objects passing in front of the star. However, variations in these time series can also occur due to non-planetary systems and a meticulous process is needed to distinguish the planets from the various false positives that are detected. HATNet is one of many surveys involved in this endeavor, and in this work I analyze HAT-P-68. First, I model the system as a single star with a transiting planet and derive estimates of the stellar and planetary physical parameters. I also model HAT-P-68 as a number of a false positives such as a pair of stars in an eclipsing binary blended with a background star, and a planet-sized star orbiting a Sun-like star. In order to rule out the possibility that HAT-P-68 is a blend, I carried out a statistical blend analysis of the photometric data and find that all blend models tested can be ruled out. Thus, I conclude that HAT-P-68 is a system with a transiting hot jupiter and consider what future observations would be most promising to further characterize the system.

  8. Adoption of open source software in business models: a Red Hat and IBM case study

    CSIR Research Space (South Africa)

    Munga, N

    2009-10-01

    Full Text Available and its position in the market identified [15]. Various types of business models are discussed in the literature. Rappa [16], using the customer relationship as the primary dimension, defines the brokerage model, information intermediary model... is growing at twice the rate of the platform business [29]. The Market After years of trying to sell to the individual consumer market, Red Hat decided to follow the money and focus its efforts on the enterprise market. The enterprise business customers...

  9. Detection of the Secondary Eclipse of Exoplanet HAT P-11b

    Science.gov (United States)

    Barry, R. K.; Deming, L. D.; Bakos, G.; Harrington, J.; Madhusudhan, N.; Noyes, R.; Seager, S.

    2010-01-01

    We have successfully conducted secondary eclipse observations of exoplanet HAT-P-11b using the Spitzer Space Telescope. HAT-P-11b was, until very recently, the smallest transiting extrasolar planet yet found and one of only two known exo-Neptunes. We observed the system at 3.6 microns for a period of 22 hours centered on the anticipated secondary eclipse time, to detect the eclipse and determine its phase. Having detected the secondary eclipse, we are at present making a more focused series of observations in both the 3.6 and 4.5 micron bands to fully characterize it. HAT-P-11b has a period of 4.8878 days, radius of 0.422 RJ, mass of 0.081 MJ and semi-major axis 0.053 AU. Measurements of the secondary eclipse will serve to clarify two key issues; 1) the planetary brightness temperature and the nature of its atmosphere, and 2) the eccentricity of its orbit, with implications for its dynamical evolution. A precise determination of the orbit phase for the secondary eclipse will also be of great utility for Kepler observations of this system at visible wavelengths.

  10. iHAT: interactive Hierarchical Aggregation Table for Genetic Association Data

    Directory of Open Access Journals (Sweden)

    Heinrich Julian

    2012-05-01

    Full Text Available Abstract In the search for single-nucleotide polymorphisms which influence the observable phenotype, genome wide association studies have become an important technique for the identification of associations between genotype and phenotype of a diverse set of sequence-based data. We present a methodology for the visual assessment of single-nucleotide polymorphisms using interactive hierarchical aggregation techniques combined with methods known from traditional sequence browsers and cluster heatmaps. Our tool, the interactive Hierarchical Aggregation Table (iHAT, facilitates the visualization of multiple sequence alignments, associated metadata, and hierarchical clusterings. Different color maps and aggregation strategies as well as filtering options support the user in finding correlations between sequences and metadata. Similar to other visualizations such as parallel coordinates or heatmaps, iHAT relies on the human pattern-recognition ability for spotting patterns that might indicate correlation or anticorrelation. We demonstrate iHAT using artificial and real-world datasets for DNA and protein association studies as well as expression Quantitative Trait Locus data.

  11. On variable geometric factor systems for top-hat electrostatic space plasma analyzers

    International Nuclear Information System (INIS)

    Collinson, Glyn A; Kataria, Dhiren O

    2010-01-01

    Even in the relatively small region of space that is the Earth's magnetosphere, ion and electron fluxes can vary by several orders of magnitude. Top-hat electrostatic analyzers currently do not possess the dynamic range required to sample plasma under all conditions. The purpose of this study was to compare, through computer simulation, three new electrostatic methods that would allow the sensitivity of a sensor to be varied through control of its geometric factor (GF) (much like an aperture on a camera). The methods studied were inner filter plates, split hemispherical analyzer (SHA) and top-cap electrode. This is the first discussion of the filter plate concept and also the first study where all three systems are studied within a common analyzer design, so that their relative merits could be fairly compared. Filter plates were found to have the important advantage that they facilitate the reduction in instrument sensitivity whilst keeping all other instrument parameters constant. However, it was discovered that filter plates have numerous disadvantages that make such a system impracticable for a top-hat electrostatic analyzer. It was found that both the top-cap electrode and SHA are promising variable geometric factor system (VGFS) concepts for implementation into a top-hat electrostatic analyzer, each with distinct advantages over the other

  12. Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes

    Directory of Open Access Journals (Sweden)

    Yoichi Sunagawa

    2018-04-01

    Full Text Available The natural compound, curcumin (CUR, possesses several pharmacological properties, including p300-specific histone acetyltransferase (HAT inhibitory activity. In our previous study, we demonstrated that CUR could prevent the development of cardiac hypertrophy by inhibiting p300-HAT activity. Other major curcuminoids isolated from Curcuma longa including demethoxycurcumin (DMC and bisdemethoxycurcumin (BDMC are structural analogs of CUR. In present study, we first confirmed the effect of these three curcuminoid analogs on p300-HAT activity and cardiomyocyte hypertrophy.Our results showed that DMC and BDMC inhibited p300-HAT activity and cardiomyocyte hypertrophy to almost the same extent as CUR. As the three compounds have structural differences in methoxy groups at the 3-position of their phenol rings, our results suggest that these methoxy groups are not involved in the inhibitory effects on p300-HAT activity and cardiac hypertrophy. These findings provide useful insights into the structure–activity relationship and biological activity of curcuminoids for p300-HAT activity and cardiomyocyte hypertrophy. Keywords: Curcumin, Demethoxycurcumin, Bisdemethoxycurcumin, p300, Cardiomyocyte hypertrophy

  13. The elliptic quantum algebra U{sub q,p}(sl-hat{sub N}) and its vertex operators

    Energy Technology Data Exchange (ETDEWEB)

    Chang Wenjing [School of Mathematical Science, Capital Normal University, Beijing 100048 (China); Ding Xiangmao [Institute of Applied Mathematics, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190 (China)], E-mail: wjchang@amss.ac.cn, E-mail: xmding@amss.ac.cn

    2009-10-23

    We construct a realization of the elliptic quantum algebra U{sub q,p}(sl-hat{sub N}) for any given level k in terms of free boson fields and their twisted partners. It can be considered as the elliptic deformation of the Wakimoto realization of the quantum affine algebra U{sub q}(sl-hat{sub N}). We also construct a family of screening currents, which commute with the currents of U{sub q,p}(sl-hat{sub N}) up to total q-differences. And we give explicit twisted expressions for the type I and type II vertex operators of U{sub q,p}(sl-hat{sub N}) by twisting the known results of the type I vertex operators of the quantum affine algebra U{sub q}(sl-hat{sub N}) and the new results of the type II vertex operators of U{sub q}(sl-hat{sub N}) we obtained in this paper.

  14. Characterization of the atmosphere of the hot Jupiter HAT-P-32Ab and the M-dwarf companion HAT-P-32B

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Ming; Wright, Jason T.; Curtis, Jason [Department of Astronomy and Astrophysics, Pennsylvania State University, PA 16802 (United States); O' Rourke, Joseph G.; Knutson, Heather A.; Ngo, Henry [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Burrows, Adam [Department of Astrophysical Sciences, Princeton University, 4 Ivy Lane, Princeton, NJ 08544 (United States); Fortney, Johnathan [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Fulton, Benjamin J.; Baranec, Christoph [Institute for Astronomy, University of Hawai' i at Mānoa, Hilo, HI 96720-2700 (United States); Riddle, Reed; Hinkley, Sasha [Division of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, CA 91125 (United States); Law, Nicholas M. [Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3255 (United States); Muirhead, Philip S. [Department of Astronomy, Boston University, 725 Commonwealth Avenue, Boston, MA 02215 (United States); Showman, Adam P. [Department of Planetary Sciences and Lunar and Planetary Laboratory, The University of Arizona, Tucson, AZ 85721 (United States); Burruss, Rick, E-mail: mingzhao@psu.edu [Jet Propulsion Laboratory, California Institute of Technology, CA 91109 (United States)

    2014-12-01

    We report secondary eclipse photometry of the hot Jupiter HAT-P-32Ab, taken with Hale/Wide-field Infra-Red Camera (WIRC) in H and K{sub S} bands and with Spitzer/IRAC at 3.6 and 4.5 μm. We carried out adaptive optics imaging of the planet host star HAT-P-32A and its companion HAT-P-32B in the near-IR and the visible. We clearly resolve the two stars from each other and find a separation of 2.''923 ± 0.''004 and a position angle 110.°64 ± 0.°12. We measure the flux ratios of the binary in g'r'i'z' and H and K{sub S} bands, and determine T {sub eff}= 3565 ± 82 K for the companion star, corresponding to an M1.5 dwarf. We use PHOENIX stellar atmosphere models to correct the dilution of the secondary eclipse depths of the hot Jupiter due to the presence of the M1.5 companion. We also improve the secondary eclipse photometry by accounting for the non-classical, flux-dependent nonlinearity of the WIRC IR detector in the H band. We measure planet-to-star flux ratios of 0.090% ± 0.033%, 0.178% ± 0.057%, 0.364% ± 0.016%, and 0.438% ± 0.020% in the H, K{sub S} , 3.6 and 4.5 μm bands, respectively. We compare these with planetary atmospheric models, and find they prefer an atmosphere with a temperature inversion and inefficient heat redistribution. However, we also find that the data are equally well described by a blackbody model for the planet with T {sub p} = 2042 ± 50 K. Finally, we measure a secondary eclipse timing offset of 0.3 ± 1.3 minutes from the predicted mid-eclipse time, which constrains e = 0.0072{sub −0.0064}{sup +0.0700} when combined with radial velocity data and is more consistent with a circular orbit.

  15. Signatures of rocky planet engulfment in HAT-P-4. Implications for chemical tagging studies

    Science.gov (United States)

    Saffe, C.; Jofré, E.; Martioli, E.; Flores, M.; Petrucci, R.; Jaque Arancibia, M.

    2017-07-01

    Aims: We aim to explore the possible chemical signature of planet formation in the binary system HAT-P-4 by studying the trends of abundance vs. condensation temperature Tc. The star HAT-P-4 hosts a planet detected by transits, while its stellar companion does not have any detected planet. We also study the lithium content, which might shed light on the problem of Li depletion in exoplanet host stars. Methods: We derived for the first time both stellar parameters and high-precision chemical abundances by applying a line-by-line full differential approach. The stellar parameters were determined by imposing ionization and excitation equilibrium of Fe lines, with an updated version of the FUNDPAR program, together with ATLAS9 model atmospheres and the MOOG code. We derived detailed abundances of different species with equivalent widths and spectral synthesis with the MOOG program. Results: The exoplanet host star HAT-P-4 is found to be 0.1 dex more metal rich than its companion, which is one of the highest differences in metallicity observed in similar systems. This could have important implications for chemical tagging studies. We rule out a possible peculiar composition for each star, such as is the case for λ Boötis and δ Scuti, and neither is this binary a blue straggler. The star HAT-P-4 is enhanced in refractory elements relative to volatile when compared to its stellar companion. Notably, the Li abundance in HAT-P-4 is greater than that of its companion by 0.3 dex, which is contrary to the model that explains the Li depletion by the presence of planets. We propose a scenario where at the time of planet formation, the star HAT-P-4 locked the inner refractory material in planetesimals and rocky planets, and formed the outer gas giant planet at a greater distance. The refractories were then accreted onto the star, possibly as a result of the migration of the giant planet. This explains the higher metallicity, the higher Li content, and the negative Tc trend we

  16. A research on the postural stability of a person wearing the lower limb exoskeletal robot by the HAT model.

    Science.gov (United States)

    Chang, Minsu; Kim, Yeongmin; Lee, Yoseph; Jeon, Doyoung

    2017-07-01

    This paper proposes a method of detecting the postural stability of a person wearing the lower limb exoskeletal robot with the HAT(Head-Arm-Trunk) model. Previous studies have shown that the human posture is stable when the CoM(Center of Mass) of the human body is placed on the BoS(Base of Support). In the case of the lower limb exoskeletal robot, the motion data, which are used for the CoM estimation, are acquired by sensors in the robot. The upper body, however, does not have sensors in each segment so that it may cause the error of the CoM estimation. In this paper, the HAT(Head-Arm-Trunk) model which combines head, arms, and torso into a single segment is considered because the motion of head and arms are unknown due to the lack of sensors. To verify the feasibility of HAT model, the reflecting markers are attached to each segment of the whole human body and the exact motion data are acquired by the VICON to compare the COM of the full body model and HAT model. The difference between the CoM with full body and that with HAT model is within 20mm for the various motions of head and arms. Based on the HAT model, the XCoM(Extrapolated Center of Mass) which includes the velocity of the CoM is used for prediction of the postural stability. The experiment of making unstable posture shows that the XCoM of the whole body based on the HAT model is feasible to detect the instance of postural instability earlier than the CoM by 20-250 msec. This result may be used for the lower limb exoskeletal robot to prepare for any action to prevent the falling down.

  17. ORBITAL PHASE VARIATIONS OF THE ECCENTRIC GIANT PLANET HAT-P-2b

    International Nuclear Information System (INIS)

    Lewis, Nikole K.; Showman, Adam P.; Knutson, Heather A.; Désert, Jean-Michel; Kao, Melodie; Cowan, Nicolas B.; Laughlin, Gregory; Fortney, Jonathan J.; Burrows, Adam; Bakos, Gáspár Á.; Hartman, Joel D.; Deming, Drake; Crepp, Justin R.; Mighell, Kenneth J.; Agol, Eric; Charbonneau, David; Fischer, Debra A.; Hinkley, Sasha; Johnson, John Asher; Howard, Andrew W.

    2013-01-01

    We present the first secondary eclipse and phase curve observations for the highly eccentric hot Jupiter HAT-P-2b in the 3.6, 4.5, 5.8, and 8.0 μm bands of the Spitzer Space Telescope. The 3.6 and 4.5 μm data sets span an entire orbital period of HAT-P-2b (P = 5.6334729 d), making them the longest continuous phase curve observations obtained to date and the first full-orbit observations of a planet with an eccentricity exceeding 0.2. We present an improved non-parametric method for removing the intrapixel sensitivity variations in Spitzer data at 3.6 and 4.5 μm that robustly maps position-dependent flux variations. We find that the peak in planetary flux occurs at 4.39 ± 0.28, 5.84 ± 0.39, and 4.68 ± 0.37 hr after periapse passage with corresponding maxima in the planet/star flux ratio of 0.1138% ± 0.0089%, 0.1162% ± 0.0080%, and 0.1888% ± 0.0072% in the 3.6, 4.5, and 8.0 μm bands, respectively. Our measured secondary eclipse depths of 0.0996% ± 0.0072%, 0.1031% ± 0.0061%, 0.071% -0.013% +0.029, and 0.1392% ± 0.0095% in the 3.6, 4.5, 5.8, and 8.0 μm bands, respectively, indicate that the planet cools significantly from its peak temperature before we measure the dayside flux during secondary eclipse. We compare our measured secondary eclipse depths to the predictions from a one-dimensional radiative transfer model, which suggests the possible presence of a transient day side inversion in HAT-P-2b's atmosphere near periapse. We also derive improved estimates for the system parameters, including its mass, radius, and orbital ephemeris. Our simultaneous fit to the transit, secondary eclipse, and radial velocity data allows us to determine the eccentricity (e = 0.50910 ± 0.00048) and argument of periapse (ω = 188.°09 ± 0.°39) of HAT-P-2b's orbit with a greater precision than has been achieved for any other eccentric extrasolar planet. We also find evidence for a long-term linear trend in the radial velocity data. This trend suggests the presence of

  18. ORBITAL PHASE VARIATIONS OF THE ECCENTRIC GIANT PLANET HAT-P-2b

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, Nikole K.; Showman, Adam P. [Department of Planetary Sciences and Lunar and Planetary Laboratory, The University of Arizona, Tucson, AZ 85721 (United States); Knutson, Heather A.; Desert, Jean-Michel; Kao, Melodie [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Cowan, Nicolas B. [Center for Interdisciplinary Exploration and Research in Astrophysics and Department of Physics and Astronomy, Northwestern University, 2131 Tech Drive, Evanston, IL 60208 (United States); Laughlin, Gregory; Fortney, Jonathan J. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Burrows, Adam; Bakos, Gaspar A.; Hartman, Joel D. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Deming, Drake [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Crepp, Justin R. [Department of Physics, University of Notre Dame, Notre Dame, IN 46556 (United States); Mighell, Kenneth J. [National Optical Astronomy Observatories, Tucson, AZ 85726 (United States); Agol, Eric [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States); Charbonneau, David [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Fischer, Debra A. [Department of Astronomy, Yale University, New Haven, CT 06511 (United States); Hinkley, Sasha; Johnson, John Asher [Department of Astrophysics, California Institute of Technology, MC 249-17, Pasadena, CA 91125 (United States); Howard, Andrew W., E-mail: nklewis@mit.edu [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); and others

    2013-04-01

    We present the first secondary eclipse and phase curve observations for the highly eccentric hot Jupiter HAT-P-2b in the 3.6, 4.5, 5.8, and 8.0 {mu}m bands of the Spitzer Space Telescope. The 3.6 and 4.5 {mu}m data sets span an entire orbital period of HAT-P-2b (P = 5.6334729 d), making them the longest continuous phase curve observations obtained to date and the first full-orbit observations of a planet with an eccentricity exceeding 0.2. We present an improved non-parametric method for removing the intrapixel sensitivity variations in Spitzer data at 3.6 and 4.5 {mu}m that robustly maps position-dependent flux variations. We find that the peak in planetary flux occurs at 4.39 {+-} 0.28, 5.84 {+-} 0.39, and 4.68 {+-} 0.37 hr after periapse passage with corresponding maxima in the planet/star flux ratio of 0.1138% {+-} 0.0089%, 0.1162% {+-} 0.0080%, and 0.1888% {+-} 0.0072% in the 3.6, 4.5, and 8.0 {mu}m bands, respectively. Our measured secondary eclipse depths of 0.0996% {+-} 0.0072%, 0.1031% {+-} 0.0061%, 0.071%{sub -0.013%}{sup +0.029,} and 0.1392% {+-} 0.0095% in the 3.6, 4.5, 5.8, and 8.0 {mu}m bands, respectively, indicate that the planet cools significantly from its peak temperature before we measure the dayside flux during secondary eclipse. We compare our measured secondary eclipse depths to the predictions from a one-dimensional radiative transfer model, which suggests the possible presence of a transient day side inversion in HAT-P-2b's atmosphere near periapse. We also derive improved estimates for the system parameters, including its mass, radius, and orbital ephemeris. Our simultaneous fit to the transit, secondary eclipse, and radial velocity data allows us to determine the eccentricity (e = 0.50910 {+-} 0.00048) and argument of periapse ({omega} = 188. Degree-Sign 09 {+-} 0. Degree-Sign 39) of HAT-P-2b's orbit with a greater precision than has been achieved for any other eccentric extrasolar planet. We also find evidence for a long

  19. REFINED SYSTEM PARAMETERS AND TTV STUDY OF TRANSITING EXOPLANETARY SYSTEM HAT-P-20

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Leilei; Gu, Shenghong; Wang, Xiaobin; Cao, Dongtao; Wang, Yibo; Xiang, Yue [Yunnan Observatories, Chinese Academy of Sciences, Kunming 650011 (China); Cameron, Andrew Collier [School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews, Fife KY16 9SS (United Kingdom); Hui, Ho-Keung; Kwok, Chi-Tai [Ho Koon Nature Education cum Astronomical Centre, Sik Sik Yuen, Hong Kong (China); Yeung, Bill; Ng, Eric [Hong Kong Astronomical Society, Hong Kong (China); Horta, Ferran Grau, E-mail: wangxb@ynao.ac.cn [Observatori Ca l’Ou, C/de Dalt 18, Sant Martí Sesgueioles (Spain)

    2017-01-01

    We report new photometric observations of the transiting exoplanetary system HAT-P-20, obtained using CCD cameras at Yunnan Observatories and Ho Koon Nature Education cum Astronomical Centre, China, from 2010 to 2013, and Observatori Ca l’Ou, Sant Marti Sesgueioles, Spain, from 2013 to 2015. The observed data are corrected for systematic errors according to the coarse de-correlation and SYSREM algorithms, so as to enhance the signal of the transit events. In order to consistently model the star spots and transits of this exoplanetary system, we develop a highly efficient tool STMT based on the analytic models of Mandel and Agol and Montalto et al. The physical parameters of HAT-P-20 are refined by homogeneously analyzing our new data, the radial velocity data, and the earlier photometric data in the literature with the Markov chain Monte Carlo technique. New radii and masses of both host star and planet are larger than those in the discovery paper due to the discrepancy of the radius among K-dwarfs between predicted values by standard stellar models and empirical calibration from observations. Through the analysis of all available mid-transit times calculated with the normal model and spotted model, we conclude that the periodic transit timing variations in these transit events revealed by employing the normal model are probably induced by spot crossing events. From the analysis of the distribution of occulted spots by HAT-P-20b, we constrain the misaligned architecture between the planetary orbit and the spin of the host star.

  20. The Discovery of Ellipsoidal Variations in the Kepler Light Curve of HAT-P-7

    OpenAIRE

    Welsh, William F.; Orosz, Jerome A.; Seager, Sara; Fortney, Jonathan J.; Jenkins, Jon; Rowe, Jason F.; Koch, David; Borucki, William J.

    2010-01-01

    We present an analysis of the early Kepler observations of the previously discovered transiting planet HAT-P-7b. The light curve shows the transit of the star, the occultation of the planet, and the orbit phase-dependent light from the planet. In addition, phase-dependent light from the star is present, known as "ellipsoidal variations". The very nearby planet (only 4 stellar radii away) gravitationally distorts the star and results in a flux modulation twice per orbit. The ellipsoidal variat...

  1. RG domain wall for the general (su)-hat (2) coset models

    Energy Technology Data Exchange (ETDEWEB)

    Stanishkov, Marian [Institute for Nuclear Research and Nuclear Energy,Bulgarian Academy of Sciences, 1784 Sofia (Bulgaria)

    2016-08-16

    We consider a RG flow in a general (su)-hat (2) coset model induced by the least relevant field. This is done using two different approaches. We first compute the mixing coefficients of certain fields in the UV and IR theories using a conformal perturbation theory. The necessary structure constants are computed. The same coefficients can be calculated using the RG domain wall construction of Gaiotto. We compute the corresponding one-point functions and show that the two approaches give the same result in the leading order.

  2. Calculating the Jet Transport Coefficient q-hat in Lattice Gauge Theory

    International Nuclear Information System (INIS)

    Majumder, Abhijit

    2013-01-01

    The formalism of jet modification in the higher twist approach is modified to describe a hard parton propagating through a hot thermalized medium. The leading order contribution to the transverse momentum broadening of a high energy (near on-shell) quark in a thermal medium is calculated. This involves a factorization of the perturbative process of scattering of the quark from the non-perturbative transport coefficient. An operator product expansion of the non-perturbative operator product which represents q -hat is carried out and related via dispersion relations to the expectation of local operators. These local operators are then evaluated in quenched SU(2) lattice gauge theory

  3. The Multiscale Bowler-Hat Transform for Vessel Enhancement in 3D Biomedical Images

    OpenAIRE

    Sazak, Cigdem; Nelson, Carl J.; Obara, Boguslaw

    2018-01-01

    Enhancement and detection of 3D vessel-like structures has long been an open problem as most existing image processing methods fail in many aspects, including a lack of uniform enhancement between vessels of different radii and a lack of enhancement at the junctions. Here, we propose a method based on mathematical morphology to enhance 3D vessel-like structures in biomedical images. The proposed method, 3D bowler-hat transform, combines sphere and line structuring elements to enhance vessel-l...

  4. Mexican hat curve for hydrogen and antihydrogen-states in natural atom H

    CERN Document Server

    Van Hooydonk, G

    2004-01-01

    Molecular band spectra as well as atomic line spectra reveal a left-right symmetry for atoms (Van Hooydonk, Spectrochim. Acta A, 2000, 56, 2273 and CERN-Ext-2002-041). We now extract a Mexican hat shaped or double well curve from the line spectrum (Lyman ns1/2 singlets) of natural atom H. An H CSB theory and its oscillator contribution (1-0.5pi/n)esp2/nexp2 lead to unprecedented results for antihydrogen physics, ahead of the CERN AD-project on artificial antihydrogen.

  5. The first successful laparoscopic Whipple procedure at Hat Yai Hospital: surgical technique and a case report.

    Science.gov (United States)

    Khaimook, Araya; Borkird, Jumpot; Alapach, Sakda

    2010-09-01

    Whipple procedure is the most complex abdominal surgical procedure to treat periampullary carcinoma. With the benefit of minimally invasive approach, many institutes attempt to do Whipple procedure laparoscopically. However, only 146 cases of laparoscopic Whipple procedure have yet been reported in the literature worldwide between 1994 and 2008. The authors reported the first laparoscopic Whipple procedure at Hat Yai Hospital in December 2009. The patient was a 40-year-old, Thai-Muslim female, with the diagnosis of ampullary carcinoma. The operating time was 685 minutes. The patient was discharged on postoperative day 14 without serious complication. The surgical technique and postoperative progress of the patient were described.

  6. Description of rainfall variability in Br hat -samhita of Varâha-mihira

    OpenAIRE

    Iyengar, RN

    2004-01-01

    Br hat -samhita of Varâha-mihira (5–6th century AD) provides valuable information on the approach in ancient India towards monsoon rainfall, including its measurement and forecasting. In this context, we come across a description of the expected amount of total seasonal rainfall depending on the first rains under the 27 naks atras of Indian astronomy. This provides a rough statistical picture of what might have been the rainfall and its variability in the region around Ujjain, where Varâha-mi...

  7. FURTHER CONSTRAINTS ON THE OPTICAL TRANSMISSION SPECTRUM OF HAT-P-1b

    International Nuclear Information System (INIS)

    Montalto, M.; Santos, N. C.; Martins, J. H. C.; Figueira, P.; Alonso, R.; Iro, N.; Desidera, S.

    2015-01-01

    We report on novel observations of HAT-P-1 aimed at constraining the optical transmission spectrum of the atmosphere of its transiting hot-Jupiter exoplanet. Ground-based differential spectrophotometry was performed over two transit windows using the DOLORES spectrograph at the Telescopio Nazionale Galileo. Our measurements imply an average planet to star radius ratio equal to R p /R * = (0.1159 ± 0.0005). This result is consistent with the value obtained from recent near-infrared measurements of this object, but differs from previously reported optical measurements, being lower by around 4.4 exoplanet scale heights. Analyzing the data over five different spectral bins of ∼600 Å wide, we observed a single peaked spectrum (3.7 σ level) with a blue cutoff corresponding to the blue edge of the broad absorption wing of sodium and an increased absorption in the region in-between 6180 and 7400 Å. We also infer that the width of the broad absorption wings due to alkali metals is likely narrower than the one implied by solar abundance clear atmospheric models. We interpret the result as evidence that HAT-P-1b has a partially clear atmosphere at optical wavelengths with a more modest contribution from an optical absorber than previously reported

  8. A Bayesian analysis of HAT-P-7b using the EXONEST algorithm

    International Nuclear Information System (INIS)

    Placek, Ben; Knuth, Kevin H.

    2015-01-01

    The study of exoplanets (planets orbiting other stars) is revolutionizing the way we view our universe. High-precision photometric data provided by the Kepler Space Telescope (Kepler) enables not only the detection of such planets, but also their characterization. This presents a unique opportunity to apply Bayesian methods to better characterize the multitude of previously confirmed exoplanets. This paper focuses on applying the EXONEST algorithm to characterize the transiting short-period-hot-Jupiter, HAT-P-7b (also referred to as Kepler-2b). EXONEST evaluates a suite of exoplanet photometric models by applying Bayesian Model Selection, which is implemented with the MultiNest algorithm. These models take into account planetary effects, such as reflected light and thermal emissions, as well as the effect of the planetary motion on the host star, such as Doppler beaming, or boosting, of light from the reflex motion of the host star, and photometric variations due to the planet-induced ellipsoidal shape of the host star. By calculating model evidences, one can determine which model best describes the observed data, thus identifying which effects dominate the planetary system. Presented are parameter estimates and model evidences for HAT-P-7b

  9. FURTHER CONSTRAINTS ON THE OPTICAL TRANSMISSION SPECTRUM OF HAT-P-1b

    Energy Technology Data Exchange (ETDEWEB)

    Montalto, M.; Santos, N. C.; Martins, J. H. C.; Figueira, P.; Alonso, R. [Instituto de Astrofísica e Ciências do Espaço, Universidade do Porto, CAUP, Rua das Estrelas, PT4150-762 Porto (Portugal); Iro, N. [Theoretical Meteorology Group Klimacampus, University of Hamburg Grindelberg 5, D-20144, Hamburg (Germany); Desidera, S., E-mail: Marco.Montalto@astro.up.pt [INAF—Osservatorio Astronomico di Padova, Vicolo dellOsservatorio 5, Padova, I-35122 (Italy)

    2015-09-20

    We report on novel observations of HAT-P-1 aimed at constraining the optical transmission spectrum of the atmosphere of its transiting hot-Jupiter exoplanet. Ground-based differential spectrophotometry was performed over two transit windows using the DOLORES spectrograph at the Telescopio Nazionale Galileo. Our measurements imply an average planet to star radius ratio equal to R{sub p}/R{sub *} = (0.1159 ± 0.0005). This result is consistent with the value obtained from recent near-infrared measurements of this object, but differs from previously reported optical measurements, being lower by around 4.4 exoplanet scale heights. Analyzing the data over five different spectral bins of ∼600 Å wide, we observed a single peaked spectrum (3.7 σ level) with a blue cutoff corresponding to the blue edge of the broad absorption wing of sodium and an increased absorption in the region in-between 6180 and 7400 Å. We also infer that the width of the broad absorption wings due to alkali metals is likely narrower than the one implied by solar abundance clear atmospheric models. We interpret the result as evidence that HAT-P-1b has a partially clear atmosphere at optical wavelengths with a more modest contribution from an optical absorber than previously reported.

  10. The G-HAT Search for Advanced Extraterrestrial Civilizations: The Reddest Extended WISE Sources

    Science.gov (United States)

    Maldonado, Jessica; Povich, Matthew S.; Wright, Jason; Griffith, Roger; Sigurdsson, Steinn; Mullan, Brendan L.

    2015-01-01

    Freeman Dyson (1960) theorized how to identify possible signatures of advanced extra-terrestrial civilizations by their waste heat, an inevitable byproduct of a civilization using a significant fraction of the luminosity from their host star. If a civilizations could tap the starlight throughout their host galaxy their waste heat would be easily detectable by recent infrared surveys. The Glimpsing Heat from Alien Technologies (G-HAT) pilot project aims to place limits on the existence of extraterrestrial civilizations at pan-galactic scales. We present results from the G-HAT cleaned catalog of 563 extremely red, extended high Galactic latitude (|b| ≥ 10) sources from the WISE All-Sky Catalog. Our catalog includes sources new to the scientific literature along with well-studied objects (e.g. starburst galaxies, AGN, and planetary nebulae) that exemplify extreme WISE colors. Objects of particular interest include a supergiant Be star (48 Librae) surrounded by a resolved, mid-infrared nebula, possibly indicating dust in the stellar wind ejecta, and a curious cluster of seven extremely red WISE sources (associated with IRAS 04287+6444) that have no optical counterparts.

  11. Implications of the Secondary Eclipse of Exoplanet HAT-P-11b

    Science.gov (United States)

    Barry, Richard K.; Deming, L. D.; Bakos, G.; Harrington, J.; Madhusudhan, N.; Noyes, R.; Seager, S.

    2010-01-01

    We observed exoplanet HAT-P-11b and have successfully detected its secondary eclipse. We conducted observations using the Spitzer Space Telescope in the post-cryo mission at 3.6 microns for a period of 22 hours centered on the anticipated secondary eclipse time, to detect the eclipse and determine its phase. Having detected the secondary eclipse, we are at present making a more focused series of observations in both the 3.6 and 4.5 micron bands to fully characterize it. HAT-P-11b is one of only two known exo-Neptunes and has a period of 4.8878 days, radius of 0.422 RJ, mass of 0.081 MJ and semi-major axis 0.053 AU. Measurements of the secondary eclipse will serve to clarify two key issues; 1) the planetary brightness temperature and the nature of its atmosphere, and 2) the eccentricity of its orbit, with implications for its dynamical evolution. We discuss implications of these observations.

  12. Magic hat economics: counter-cultural ideals and practices of the Nordic Ting community

    Directory of Open Access Journals (Sweden)

    Janne Juhana Rantala

    2009-01-01

    Full Text Available The author's anthropological study concerns one of today’s communities with no shared belief system, but with a clear spiritualist orientation. The Nordic Ting Community does not have any defined or committing roles, specialized distribution of tasks, entrance fee to their two annual gatherings, membership or any formal hierarchy. This exiguity of structural differentiation could well be understood to represent ‘subjective spirituality’. This thesis refers to the decline of institutional forms of religion with, instead, an increase in subjective experience in spirituality. This presentation shows that at least in the author's field of study, there hardly exists any increase in emphasis on individualism in spirituality. Instead the material indicates a relatively long continuum of a self-organized type of communality which could be understood as neither individualistic nor collectivistic. The type of agency observed in the social action of the studied network-like field is intersubjective. This article focuses on the use of the magic hat and the combination of ideals and practices characteristic to the Ting Community, which the author calls the magic hat economics. It is argued that by looking at these kinds of intermediating objects, the problem of individualization can be seen much more clearly

  13. The Occupancy Rate Modeling of Kendari Hotel Room using Mexican Hat Transformation and Partial Least Squares

    Directory of Open Access Journals (Sweden)

    Margaretha Ohyver

    2016-12-01

    Full Text Available Partial Least Squares (PLS method was developed in 1960 by Herman Wold. The method particularly suits with construct a regression model when the number of independent variables is many and highly collinear. The PLS can be combined with other methods, one of which is a Continuous Wavelet Transformation (CWT. By considering that the presence of outliers can lead to a less reliable model, and this kind of transformation may be required at a stage of pre-processing, the data is free of noise or outliers. Based on the previous study, Kendari hotel room occupancy rate was affected by the outlier, and it had a low value of R2. Therefore, this research aimed to obtain a good model by combining the PLS method and CWT transformation using the Mexican Hats them other wavelet of CWT. The research concludes that merging the PLS and the Mexican Hat transformation has resulted in a better model compared to the model that combined the PLS and the Haar wavelet transformation as shown in the previous study. The research shows that by changing the mother of the wavelet, the value of R2 can be improved significantly. The result provides information on how to increase the value of R2. The other advantage is the information for hotel managements to notice the age of the hotel, the maximum rates, the facilities, and the number of rooms to increase the number of visitors.

  14. Assessment of seeps in the vicinity of the Mexican Hat tailings disposal cell

    International Nuclear Information System (INIS)

    1990-10-01

    The Phase II remedial action at the Mexican Hat site began in September 1988, and involved the excavation, transportation, and placement of contaminated materials onto the lower tailings pile. These materials were from the upper tailings pile, portions of the lower tailings pile, off-pile contaminated areas, and demolition material stockpiled at the former-mill site. By December 1989, all of the contaminated soils on the upper tailings pile area and most of the off-pile windblown and waterborne contamination had been removed and placed on the lower pile. Since that time, several seeps have been observed near the site. These seeps and some previously identified seeps may be related to remedial action construction activities or the past disposal of mill tailings at the Mexican Hat site. The objectives of this report are to: summarize the geology and hydrostratigraphy of the site; discuss field investigation of the locations, chronology, and flow rates of the seeps; discuss background groundwater quality, tailings pore fluid characterization, and water quality of the seeps; identify possible sources of the seeps; interpret the data; make recommendations for continued site characterization and assessment

  15. Climatic change and environmental implications in the Medicine Hat region using Billings, Montana as an analogue

    International Nuclear Information System (INIS)

    Proudfoot, W.A.

    1994-01-01

    There is concern that climatic change due to anthropogenic enhancement of the greenhouse effect may have considerable impacts on the natural and agricultural environments in Canada. The Palliser Triangle in the southern prairie region is an area in which the impacts of climatic change could be significant; it is an important agricultural zone and is already sensitive due to its semi-arid climate. The possible effects of a change in the climate of the Medicine Hat (Alberta) area in the Palliser Triangle is examined through the use of a regional analogue in a warmer, more southerly area. The selected analogue region is the area around Billings, Montana. Aspects of the natural environment, including potential vegetation distribution, frost-free period, and drought, as well as aspects of the agricultural environment, including agricultural practices and examination of wheat yields, are studied within each region. Comparisons are drawn between the two regions to evaluate whether significant differences exist in the environmental aspects examined. It is shown that although a change in Medicine Hat's climate to one more like that of Billings may not have drastic impacts on the environment, such a change may require adjustments in current practices or adaptations to altered environmental conditions. Reviews of several policy areas will be necessary to ensure appropriate adjustments in agricultural or resource management practices. Regional analogy is shown to be an essential preliminary tool for determining possible effects of climatic change. 138 refs., 42 figs., 22 tabs

  16. HAT-P-26b: A Neptune-mass exoplanet with a well-constrained heavy element abundance.

    Science.gov (United States)

    Wakeford, Hannah R; Sing, David K; Kataria, Tiffany; Deming, Drake; Nikolov, Nikolay; Lopez, Eric D; Tremblin, Pascal; Amundsen, David S; Lewis, Nikole K; Mandell, Avi M; Fortney, Jonathan J; Knutson, Heather; Benneke, Björn; Evans, Thomas M

    2017-05-12

    A correlation between giant-planet mass and atmospheric heavy elemental abundance was first noted in the past century from observations of planets in our own Solar System and has served as a cornerstone of planet-formation theory. Using data from the Hubble and Spitzer Space Telescopes from 0.5 to 5 micrometers, we conducted a detailed atmospheric study of the transiting Neptune-mass exoplanet HAT-P-26b. We detected prominent H 2 O absorption bands with a maximum base-to-peak amplitude of 525 parts per million in the transmission spectrum. Using the water abundance as a proxy for metallicity, we measured HAT-P-26b's atmospheric heavy element content ([Formula: see text] times solar). This likely indicates that HAT-P-26b's atmosphere is primordial and obtained its gaseous envelope late in its disk lifetime, with little contamination from metal-rich planetesimals. Copyright © 2017, American Association for the Advancement of Science.

  17. Radiologic characterization of the Mexican Hat, Utah, uranium mill tailings remedial action site: Appendix D, Addenda D1--D7

    Energy Technology Data Exchange (ETDEWEB)

    Ludlam, J.R.

    1985-01-01

    This radiologic characterization of the inactive uranium millsite at Mexican Hat, Utah, was conducted by Bendix Field Engineering Corporation foe the US Department of Energy (DOE), Grand Junction Project Office, in response to and in accord with a Statement of Work prepared by the DOE Uranium Mill tailings Remedial Action Project (UMTRAP) Technical Assistance Contractor, Jacobs Engineering Group, Inc. the objective of this project was to determine the horizontal and vertical extent of contamination that exceeds the US Environmental Protection Agency (EPA) standards at the Mexican Hat site. The data presented in this report are required for characterization of the areas adjacent to the Mexican Hat tailings piles and for the subsequent design of cleanup activities. Some on-pile sampling was required to determine the depth of the 15-pCi/g Ra-226 interface in an area where wind and water erosion has taken place.

  18. Engineering assessment of inactive uranium mill tailings, Mexican Hat site, Mexican Hat, Utah. A summary of the Phase II, Title I

    International Nuclear Information System (INIS)

    1977-01-01

    Ford, Bacon and Davis Utah Inc. has performed an engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at the Mexican Hat millsite in Utah. The Phase II, Title I services include the preparation of topographic maps, the performance of core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and other radium-contaminated materials, the evaluation of resulting radiation exposures of individuals residing nearby, the investigation of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions. Radon gas release from the 2,200,000 tons of tailings on the site constitutes the most significant environmental impact. The six alternative actions presented are directed towards restricting access to the site (Option I), returning the windblown tailings to the piles and stabilizing the piles with cover material (Options II, III, and IV), and consolidating the two piles into one pile and stabilizing it with cover material (Options V and VI). Fencing around the site or the tailings and the decontamination of mill buildings is included in all options. Options II and V provide 2 ft of cover material on the tailings, Options III, IV, and VI provide 4 ft, 13 ft, and 10 ft of cover, respectively. Costs of the options range from $370,000 to $4,390,000. Reprocessing the tailings for uranium is not feasible at present

  19. Observations and modeling of the transiting exoplanets XO-2b, HAT-P-18b, and WASP-80b

    Directory of Open Access Journals (Sweden)

    Kjurkchieva Diana P.

    2017-01-01

    Full Text Available We present photometric observations and transit solutions of the exoplanets XO-2b, HAT-P-18b and WASP 80b. Our solution of the XO-2b transit gave system parameters whose values are close to those of the previous studies. The solutions of the new transits of HAT-P-18b and WASP 80b differ from the previous ones by bigger stellar and planet radii. We obtained new values of the target initial epochs corresponding to slightly different periods. Our investigation reaffirmed that small telescopes can be used successfully for the study of exoplanets orbiting stars brighter than 13 mag.

  20. Final audit report of remedial action construction at the UMTRA Project Mexican Hat, Utah -- Monument Valley, Arizona, sites

    International Nuclear Information System (INIS)

    1995-10-01

    The final audit report for remedial action at the Mexican Hat, Utah, Monument Valley, Arizona, Uranium Mill Tailings Remedial Action (UMTRA) Project sites consists of a summary of the radiological surveillances/audits, quality assurance (QA) in-process surveillances, and QA remedial action close-out inspections performed by the US Department of Energy (DOE) and the Technical Assistance Contractor (TAC); on-site construction reviews (OSCR) performed by the US Nuclear Regulatory Commission (NRC); and a surveillance performed by the Navajo Nation. This report refers to remedial action activities performed at the Mexican Hat, Utah--Monument Valley, Arizona, Uranium Mill Tailings Remedial Action (UMTRA) Project sites

  1. Spontaneous breaking of chiral symmetry, and eventually of parity, in a σ-model with two Mexican hats

    International Nuclear Information System (INIS)

    Giacosa, Francesco

    2010-01-01

    A σ-model with two linked Mexican hats is discussed. This scenario could be realized in low-energy QCD when the ground state and the first excited (pseudo)scalar mesons are included, and where not only in the subspace of the ground states, but also in that of the first excited states, a Mexican hat potential is present. This possibility can change some basic features of a low-energy hadronic theory of QCD. It is also shown that spontaneous breaking of parity can occur in the vacuum for some parameter choice of the model. (orig.)

  2. Kavunda ebeveyn hat ile melezlerinin bazı tohum ve tohum çıkışı özelliklerinin belirlenmesi

    OpenAIRE

    TUR, Ayşegül; SEYMEN, Musa; TÜRKMEN, Önder

    2018-01-01

    Bu çalışma, 2015-2016 yıllarında yürütülmüş ve bitkisel materyal olarak, 13 genotip (SÇ-1: Sel-1-1. SÇ-2: Sel-1-2. SÇ-3: Sel-2. SÇ-4: Sel-3. SÇ-5: Sel-4. SÇ-6: Sel-6-1. SÇ-7: Sel-6-2. SÇ-8: Sel-7. SÇ-9: Sel-8. SÇ-10: Sel-9. SÇ-11: Sel-10. SÇ-12: Sel-11. SÇ-13: Pop. Diyarbakır). 4 ebeveyn hat (EB-1: saf hat-7. EB-2: saf hat-A4. EB-3: saf hat-G22. EB-4: saf hat-136) ve 9 melez (M-1: safhat 7xsafhat-136. M-2: safhat-7xsafhat-A4. M-3: safhat-7xsafhat-G22. M-4: safhat-G22xsafhat-136. M-5: safhat-G...

  3. HAT-P-65b and HAT-P-66b: Two Transiting Inflated Hot Jupiters and Observational Evidence for the Reinflation of Close-in Giant Planets

    Science.gov (United States)

    Hartman, J. D.; Bakos, G. Á.; Bhatti, W.; Penev, K.; Bieryla, A.; Latham, D. W.; Kovács, G.; Torres, G.; Csubry, Z.; de Val-Borro, M.; Buchhave, L.; Kovács, T.; Quinn, S.; Howard, A. W.; Isaacson, H.; Fulton, B. J.; Everett, M. E.; Esquerdo, G.; Béky, B.; Szklenar, T.; Falco, E.; Santerne, A.; Boisse, I.; Hébrard, G.; Burrows, A.; Lázár, J.; Papp, I.; Sári, P.

    2016-12-01

    We present the discovery of the transiting exoplanets HAT-P-65b and HAT-P-66b, with orbital periods of 2.6055 and 2.9721 days, masses of 0.527+/- 0.083 {M}{{J}} and 0.783+/- 0.057 {M}{{J}}, and inflated radii of 1.89+/- 0.13 {R}{{J}} and {1.59}-0.10+0.16 {R}{{J}}, respectively. They orbit moderately bright (V=13.145+/- 0.029 and V=12.993+/- 0.052) stars of mass 1.212+/- 0.050 {M}⊙ and {1.255}-0.054+0.107 {M}⊙ . The stars are at the main-sequence turnoff. While it is well known that the radii of close-in giant planets are correlated with their equilibrium temperatures, whether or not the radii of planets increase in time as their hosts evolve and become more luminous is an open question. Looking at the broader sample of well-characterized close-in transiting giant planets, we find that there is a statistically significant correlation between planetary radii and the fractional ages of their host stars, with a false-alarm probability of only 0.0041%. We find that the correlation between the radii of planets and the fractional ages of their hosts is fully explained by the known correlation between planetary radii and their present-day equilibrium temperatures; however, if the zero-age main-sequence equilibrium temperature is used in place of the present-day equilibrium temperature, then a correlation with age must also be included to explain the planetary radii. This suggests that, after contracting during the pre-main-sequence, close-in giant planets are reinflated over time due to the increasing level of irradiation received from their host stars. Prior theoretical work indicates that such a dynamic response to irradiation requires a significant fraction of the incident energy to be deposited deep within the planetary interiors. Based on observations obtained with the Hungarian-made Automated Telescope Network. Based on observations obtained at the W. M. Keck Observatory, which is operated by the University of California and the California Institute of Technology

  4. Spherical top-hat collapse of a viscous unified dark fluid

    Energy Technology Data Exchange (ETDEWEB)

    Li, Wei [Bohai University, Department of Physics, Jinzhou (China); Dalian University of Technology, Institute of Theoretical Physics, Dalian (China); Xu, Lixin [Dalian University of Technology, Institute of Theoretical Physics, Dalian (China)

    2014-05-15

    In this paper, we test the spherical collapse of a viscous unified dark fluid (VUDF) which has constant adiabatic sound speed and show the nonlinear collapse for VUDF, baryons, and darkmatter, which are important in forming the large-scale structure of our Universe. By varying the values of the model parameters α and ζ{sub 0}, we discuss their effects on the nonlinear collapse of the VUDF model, and we compare its result to the ΛCDM model. The results of the analysis show that, within the spherical top-hat collapse framework, larger values of α and smaller values of ζ{sub 0} make the structure formation earlier and faster, and the other collapse curves are almost distinguished with the curve of ΛCDM model if the bulk viscosity coefficient ζ{sub 0} is less than 10{sup -3}. (orig.)

  5. Sum of top-hat transform based algorithm for vessel enhancement in MRA images

    Science.gov (United States)

    Ouazaa, Hibet-Allah; Jlassi, Hajer; Hamrouni, Kamel

    2018-04-01

    The Magnetic Resonance Angiography (MRA) is rich with information's. But, they suffer from poor contrast, illumination and noise. Thus, it is required to enhance the images. But, these significant information can be lost if improper techniques are applied. Therefore, in this paper, we propose a new method of enhancement. We applied firstly the CLAHE method to increase the contrast of the image. Then, we applied the sum of Top-Hat Transform to increase the brightness of vessels. It is performed with the structuring element oriented in different angles. The methodology is tested and evaluated on the publicly available database BRAINIX. And, we used the measurement methods MSE (Mean Square Error), PSNR (Peak Signal to Noise Ratio) and SNR (Signal to Noise Ratio) for the evaluation. The results demonstrate that the proposed method could efficiently enhance the image details and is comparable with state of the art algorithms. Hence, the proposed method could be broadly used in various applications.

  6. Logarithmic sℓ-hat (2) CFT models from Nichols algebras: I

    International Nuclear Information System (INIS)

    Semikhatov, A M; Tipunin, I Yu

    2013-01-01

    We construct chiral algebras that centralize rank-2 Nichols algebras with at least one fermionic generator. This gives ‘logarithmic’ W-algebra extensions of a fractional-level sℓ-hat (2) algebra. We discuss crucial aspects of the emerging general relation between Nichols algebras and logarithmic conformal field theory (CFT) models: (i) the extra input, beyond the Nichols algebra proper, needed to uniquely specify a conformal model; (ii) a relation between the CFT counterparts of Nichols algebras connected by Weyl groupoid maps; and (iii) the common double bosonization U(X) of such Nichols algebras. For an extended chiral algebra, candidates for its simple modules that are counterparts of the U(X) simple modules are proposed, as a first step toward a functorial relation between U(X) and W-algebra representation categories. (paper)

  7. Assessment of the radiological impact of the inactive uranium-mill tailings at Mexican Hat, Utah

    Energy Technology Data Exchange (ETDEWEB)

    Haywood, F.F.; Goldsmith, W.A.; Ellis, B.S.; Hubbard, H.M. Jr.; Fox, W.F.; Shinpaugh, W.H.

    1980-03-01

    High surface soil concentrations of /sup 226/Ra and high above-ground measurements of gamma-ray intensity in the vicinity of the inactive uranium-mill tailings at Mexican Hat show both wind and water erosion of the tailings. The former mill area, occupied by a trade school at the time of this survey, shows a comparatively high level of contamination, probably from unprocessed ore on the surface of the ore storage area near the location of the former mill buildings. However, the estimated health effect of exposure to gamma rays during a 2000-hr work year in the area represents an increase of 0.1% in the risk of death from cancer. Exposure of less than 600 persons within 1.6 km of the tailings to radon daughters results in an estimated 0.2%/year increase in risk of lung cancer.

  8. A 82Br tracer study of coastal groundwater movement at Hat Head, NSW

    International Nuclear Information System (INIS)

    Hughes, C.; Stone, D.

    2003-01-01

    At Hat Head, NSW, on the eastern Australian coast, a radioisotope tracer study of groundwater flow in response to tidal forcing was conducted adjacent to a tidal creek. Using radiotracer, 82 Br, groundwater movement was tracked in-situ over 5 days on two occasions encompassing both neap and spring tide conditions. The tracer was injected into one borehole and gamma counts monitored from an adjacent borehole using NaI(Th) detectors. This technique maps the path of the slow moving tracer without sampling and allows the net groundwater movement to be distinguished from short term tidally driven fluxes. During the neap tide period net groundwater movement of 0.1 m/d was observed with horizontal tidal fluctuations in the order of 0.04 m. This contrasts with the tidally dominated spring tide period where net groundwater movement was negligible but tidally driven fluctuations of up to 0.13 m were observed

  9. "It's your badge of inclusion": the Red Hat Society as a gendered subculture of aging.

    Science.gov (United States)

    Barrett, Anne E; Pai, Manacy; Redmond, Rebecca

    2012-12-01

    Although studies document the health-enhancing effects of social engagement, they reveal little about the underlying mechanisms operating within specific organizational contexts. Limited attention is given to the role of inequality--particularly age and gender--in shaping either the organizations to which we belong or their consequences for our well-being. We address this issue by examining the Red Hat Society, a social organization for middle-aged and older women. Interviews with members (n=52) illustrate how age and gender inequality interact to shape the organization, which can be viewed as a gendered subculture of aging. Drawing on this framework, we discuss four processes through which participation generates benefits for older women involved in age- and gender-segregated organizations: enhancing social networks, countering invisibility, creating positive frames for aging experiences, and promoting youthful identities. Copyright © 2012 Elsevier Inc. All rights reserved.

  10. 3D spin-orbit angle of Kepler-25 and HAT-P-7

    Directory of Open Access Journals (Sweden)

    Benomar Othman

    2015-01-01

    Full Text Available The number of discovered exoplanets now exceeds 1500, mostly due to the Kepler space instrument observations. Many of these planet orbit in less than a week around their host stars. This implies that the inward migration of those planets is a basic ingredient of successful theories of planet formation and evolution. Several mechanisms have been proposed to explain the observed periods, which lead to different orbit eccentricity and obliquity distributions. Here we summarise and discuss the results of obliquities for two Kepler stars: HAT-P-7 and Kepler-25. These are interesting stellar systems as we could carry out a joint analysis using asteroseismology, transit lightcurve and the Rossiter-McLaughlin effect in order to measure the three dimensional obliquity.

  11. Assessment of the radiological impact of the inactive uranium-mill tailings at Mexican Hat, Utah

    International Nuclear Information System (INIS)

    Haywood, F.F.; Goldsmith, W.A.; Ellis, B.S.; Hubbard, H.M. Jr.; Fox, W.F.; Shinpaugh, W.H.

    1980-03-01

    High surface soil concentrations of 226 Ra and high above-ground measurements of gamma-ray intensity in the vicinity of the inactive uranium-mill tailings at Mexican Hat show both wind and water erosion of the tailings. The former mill area, occupied by a trade school at the time of this survey, shows a comparatively high level of contamination, probably from unprocessed ore on the surface of the ore storage area near the location of the former mill buildings. However, the estimated health effect of exposure to gamma rays during a 2000-hr work year in the area represents an increase of 0.1% in the risk of death from cancer. Exposure of less than 600 persons within 1.6 km of the tailings to radon daughters results in an estimated 0.2%/year increase in risk of lung cancer

  12. A near-infrared transmission spectrum for the warm Saturn HAT-P-12b

    Energy Technology Data Exchange (ETDEWEB)

    Line, Michael R.; Knutson, Heather; Desert, Jean-Michel [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Deming, Drake; Wilkins, Ashlee, E-mail: mrl@gps.caltech.edu [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States)

    2013-12-01

    We present a Hubble Space Telescope Wide Field Camera-3 (WFC3) transmission spectrum for the transiting exoplanet HAT-P-12b. This warm (1000 K) sub-Saturn-mass planet has a smaller mass and a lower temperature than the hot Jupiters that have been studied so far. We find that the planet's measured transmission spectrum lacks the expected water absorption feature for a hydrogen-dominated atmosphere and is instead best described by a model with high-altitude clouds. Using a frequentist hypothesis testing procedure, we can rule out a hydrogen-dominated cloud-free atmosphere to 4.9σ. When combined with other recent WFC3 studies, our observations suggest that clouds may be common in exoplanetary atmospheres.

  13. SPITZER IRAC SECONDARY ECLIPSE PHOTOMETRY OF THE TRANSITING EXTRASOLAR PLANET HAT-P-1b

    International Nuclear Information System (INIS)

    Todorov, Kamen; Deming, Drake; Harrington, Jospeph; Stevenson, Kevin B.; Bowman, William C.; Nymeyer, Sarah; Fortney, Jonathan J.; Bakos, Gaspar A.

    2010-01-01

    We report Spitzer/IRAC photometry of the transiting giant exoplanet HAT-P-1b during its secondary eclipse. This planet lies near the postulated boundary between the pM and pL-class of hot Jupiters, and is important as a test of models for temperature inversions in hot Jupiter atmospheres. We derive eclipse depths for HAT-P-1b, in units of the stellar flux, that are: 0.080% ± 0.008% [3.6 μm], 0.135% ± 0.022% [4.5 μm], 0.203% ± 0.031% [5.8 μm], and 0.238% ± 0.040% [8.0 μm]. These values are best fit using an atmosphere with a modest temperature inversion, intermediate between the archetype inverted atmosphere (HD 209458b) and a model without an inversion. The observations also suggest that this planet is radiating a large fraction of the available stellar irradiance on its dayside, with little available for redistribution by circulation. This planet has sometimes been speculated to be inflated by tidal dissipation, based on its large radius in discovery observations, and on a non-zero orbital eccentricity allowed by the radial velocity data. The timing of the secondary eclipse is very sensitive to orbital eccentricity, and we find that the central phase of the eclipse is 0.4999 ± 0.0005. The difference between the expected and observed phase indicates that the orbit is close to circular, with a 3σ limit of |e cos ω| < 0.002.

  14. TCUP: A novel hAT transposon active in maize tissue culture

    Directory of Open Access Journals (Sweden)

    Alan eSmith

    2012-01-01

    Full Text Available Transposable elements are capable of inducing heritable de novo genetic variation. The sequences capable of reactivation, and environmental factors that induce mobilization, remain poorly defined even in well-studied genomes such as maize. We treated maize tissue culture with the demethylating agent 5-aza-2-deoxcytidine and examined long-term tissue culture lines to discover silenced transposable elements that have the potential to induce heritable genetic variation. Through these screens we have identified a novel low copy number hAT transposon, Tissue Culture Up-Regulated (TCUP, which is transcribed at high levels in long-term maize Black Mexican Sweet (BMS tissue culture and up-regulated in response to treatment with 5-aza-2-deoxycytidine. Analysis of the TIGR Maize Gene Index revealed that this element is the most frequently represented EST from the BMS cell culture library and is not represented in other tissue libraries, which is the basis for its name. A full-length sequence was assembled in inbred B73 that contains the putative functional motifs required for autonomous movement of a hAT transposon. Transposon display detected movement of TCUP in two long-term tissue cultured cell lines of the genotype Hi-II AxB and BMS. This research implicates TCUP as a transposon that is capable of reactivation and which may also be particularly sensitive to the stress of the tissue culture environment. Our findings are consistent with the hypothesis that epigenetic alterations potentiate genomic responses to stress during clonal propagation of plants.

  15. Kepler and Ground-Based Transits of the exo-Neptune HAT-P-11b

    Science.gov (United States)

    Deming, Drake; Sada, Pedro V.; Jackson, Brian; Peterson, Steven W.; Agol, Eric; Knutson, Heather A.; Jennings, Donald E.; Haase, Plynn; Bays, Kevin

    2011-01-01

    We analyze 26 archival Kepler transits of the exo-Neptune HAT-P-11b, supplemented by ground-based transits observed in the blue (B band) and near-IR (J band). Both the planet and host star are smaller than previously believed; our analysis yields Rp = 4.31 R xor 0.06 R xor and Rs = 0.683 R solar mass 0.009 R solar mass, both about 3 sigma smaller than the discovery values. Our ground-based transit data at wavelengths bracketing the Kepler bandpass serve to check the wavelength dependence of stellar limb darkening, and the J-band transit provides a precise and independent constraint on the transit duration. Both the limb darkening and transit duration from our ground-based data are consistent with the new Kepler values for the system parameters. Our smaller radius for the planet implies that its gaseous envelope can be less extensive than previously believed, being very similar to the H-He envelope of GJ 436b and Kepler-4b. HAT-P-11 is an active star, and signatures of star spot crossings are ubiquitous in the Kepler transit data. We develop and apply a methodology to correct the planetary radius for the presence of both crossed and uncrossed star spots. Star spot crossings are concentrated at phases 0.002 and +0.006. This is consistent with inferences from Rossiter-McLaughlin measurements that the planet transits nearly perpendicular to the stellar equator. We identify the dominant phases of star spot crossings with active latitudes on the star, and infer that the stellar rotational pole is inclined at about 12 deg 5 deg to the plane of the sky. We point out that precise transit measurements over long durations could in principle allow us to construct a stellar Butterfly diagram to probe the cyclic evolution of magnetic activity on this active K-dwarf star.

  16. Density functional calculations of potential energy surface and charge transfer integrals in molecular triphenylene derivative HAT6

    NARCIS (Netherlands)

    Zbiri, M.; Johnson, M.R.; Kearley, G.J.; Mulder, F.M.

    2009-01-01

    We investigate the effect of structural fluctuations on charge transfer integrals, overlap integrals, and site energies in a system of two stacked molecular 2,3,6,7,10,11-hexakishexyloxytriphenylene (HAT6), which is a model system for conducting devices in organic photocell applications. A density

  17. BALTIMORE’S M.S. LEVY AND SONS: Straw Hat Makers to the World, 1870-1960

    Directory of Open Access Journals (Sweden)

    Jessica I. Elfenbein

    2008-01-01

    Full Text Available From 1860 to 1960, Baltimore was an important center of the men’s ready-to- wear clothing industries. German-speaking Jews created many businesses that manufactured and sold underwear, men’s suits, and specialty items like hats and umbrellas. The straw hat making firm started by M.S. Levy is an interesting example of a Baltimore-based, family-owned niche business that existedfor 90 years, through three generations ofa singlefamily. The M.S. Levy and Sons story has two main chapters. The first covers the period from its founding by Michael Simon Levy in the 1870s through his son Julius’ death in 1926. This is the story of ascension. A premonition about the coming popularity of straw hats, together with a small but important technological breakthrough, positioned a family and a small industry for significant expansion. The second period began in 1930 with the introduction of wool felt hats and the death of William, M.S. Levy’s oldest son, and includes the Great Depression, unionization, merger, third generation leadership, and finally, in 1959, the family’s withdrawal from the industry. This later period, as told by grandsons of the founder, is the story of struggle followed by decline.

  18. Inhibition of Different Histone Acetyltransferases (HATs) Uncovers Transcription-Dependent and -Independent Acetylation-Mediated Mechanisms in Memory Formation

    Science.gov (United States)

    Merschbaecher, Katja; Hatko, Lucyna; Folz, Jennifer; Mueller, Uli

    2016-01-01

    Acetylation of histones changes the efficiency of the transcription processes and thus contributes to the formation of long-term memory (LTM). In our comparative study, we used two inhibitors to characterize the contribution of different histone acetyl transferases (HATs) to appetitive associative learning in the honeybee. For one we applied…

  19. Path representation of su-hat (2){sub k} states I: Operators and particles for k=1,2

    Energy Technology Data Exchange (ETDEWEB)

    Lamy-Poirier, Joel, E-mail: jlamypoirier@perimeterinstitute.c [Departement de physique, de genie physique et d' optique, Universite Laval, Quebec, G1K 7P4 (Canada); Mathieu, Pierre, E-mail: pmathieu@phy.ulaval.c [Departement de physique, de genie physique et d' optique, Universite Laval, Quebec, G1K 7P4 (Canada)

    2011-04-11

    This is the first of two articles devoted to the analysis of the path description of the states in su-hat (2){sub k} WZW models, a representation well suited for constructive derivations of the fermionic characters. In this first article, the cases k=1,2 are treated in detail, emphasizing a different description in each case (operators vs particles). For k=1, we first prove, as a side result, the equivalence of two known path representations for the finitized su-hat (2){sub 1} states by displaying an explicit bijection. An immediate offshoot is the gain of a new and simple weighting for the (Kyoto) path representation that generalizes to level k. The bijection also suggests two operator constructions for the su-hat (2){sub 1} paths, a local and a nonlocal one, both interrelated. These are formal operators that map a path to another path, so that any path can be obtained by successive applications of these operators on a simple reference (ground-state) path. The nonlocal operator description is the starting point for a direct and elementary derivation of the su-hat (2){sub 1} spinon character. The second part presents an extensive study of the su-hat (2){sub 2} paths from their particle point of view, where the particles are defined as the path building blocks. The resulting generating functions appear to provide new (at least superficially) fermionic forms of the characters. In particular, a nice relationship between the sum of the j=0,1 characters at k=2 and the two ones at k=1 is unraveled.

  20. Imbalance between HAT and HDAC activities in the PBMCs of patients with ankylosing spondylitis or rheumatoid arthritis and influence of HDAC inhibitors on TNF alpha production.

    Directory of Open Access Journals (Sweden)

    Eric Toussirot

    Full Text Available OBJECTIVE: Acetylation or deacetylation of histone proteins may modulate cytokine gene transcription such as TNF alpha (TNF. We evaluated the balance between histone deacetytlase (HDAC and histone acetyltransferase (HAT in patients with rheumatoid arthritis (RA or ankylosing spondylitis (AS compared to healthy controls (HC and determined the influence of HDAC inhibitors (trichostatin A -TSA- or Sirtinol -Sirt- on these enzymatic activities and on the PBMC production of TNF. METHODS: 52 patients with RA, 21 with AS and 38 HC were evaluated. HAT and HDAC activities were measured on nuclear extracts from PBMC using colorimetric assays. Enzymatic activities were determined prior to and after ex vivo treatment of PBMC by TSA or Sirt. TNF levels were evaluated in PBMC culture supernatants in the absence or presence of TSA or Sirt. RESULTS: HAT and HDAC activities were significantly reduced in AS, while these activities reached similar levels in RA and HC. Ex vivo treatment of PBMC by HDACi tended to decrease HDAC expression in HC, but Sirt significantly reduced HAT in RA. TNF production by PBMC was significantly down-regulated by Sirt in HC and AS patients. CONCLUSION: HAT and HDAC were disturbed in AS while no major changes were found in RA. HDACi may modulate HDAC and HAT PBMC expression, especially Sirt in RA. Sirtinol was able to down regulate TNF production by PBMC in HC and AS. An imbalance between HAT and HDAC activities might provide the rationale for the development of HDACi in the therapeutic approach to inflammatory rheumatic diseases.

  1. HAT-P-13b,c: A TRANSITING HOT JUPITER WITH A MASSIVE OUTER COMPANION ON AN ECCENTRIC ORBIT

    International Nuclear Information System (INIS)

    Bakos, G. A.; Noyes, R. W.; Hartman, J.; Torres, G.; Latham, D. W.; Sasselov, D. D.; Stefanik, R. P.; Sipocz, B.; Kovacs, Gabor; Esquerdo, G. A.; Pal, A.; Howard, A. W.; Marcy, G. W.; Kovacs, Geza; Fischer, D. A.; Johnson, J. A.; Lazar, J.; Papp, I.; Sari, P.

    2009-01-01

    We report on the discovery of a planetary system with a close-in transiting hot Jupiter on a near circular orbit and a massive outer planet on a highly eccentric orbit. The inner planet, HAT-P-13b, transits the bright V = 10.622 G4 dwarf star GSC 3416 - 00543 every P = 2.916260 ± 0.000010 days, with transit epoch T c = 2454779.92979 ± 0.00038 (BJD) and duration 0.1345 ± 0.0017 days. The outer planet HAT-P-13c orbits the star every P 2 = 428.5 ± 3.0 days with a nominal transit center (assuming zero impact parameter) of T 2c = 2454870.4 ± 1.8 (BJD) or time of periastron passage T 2,peri = 2454890.05 ± 0.48 (BJD). Transits of the outer planet have not been observed, and may not be present. The host star has a mass of 1.22 +0.05 -0.10 M sun , radius of 1.56 ± 0.08 R sun , effective temperature of 5653 ± 90 K, and is rather metal-rich with [Fe/H] = +0.41 ± 0.08. The inner planetary companion has a mass of 0.853 +0.029 -0.046 M J , and radius of 1.281 ± 0.079 R J , yielding a mean density of 0.498 +0.103 -0.069 g cm -3 . The outer companion has m 2 sin i 2 = 15.2 ± 1.0 M J , and orbits on a highly eccentric orbit of e 2 = 0.691 ± 0.018. While we have not detected significant transit timing variations of HAT-P-13b, due to gravitational and light-travel time effects, future observations will constrain the orbital inclination of HAT-P-13c, along with its mutual inclination to HAT-P-13b. The HAT-P-13 (b, c) double-planet system may prove extremely valuable for theoretical studies of the formation and dynamics of planetary systems.

  2. Structure of the Hat Creek graben region: Implications for the structure of the Hat Creek graben and transfer of right-lateral shear from the Walker Lane north of Lassen Peak, northern California, from gravity and magnetic anomalies

    Science.gov (United States)

    Langenheim, Victoria; Jachens, Robert C.; Clynne, Michael A.; Muffler, L. J. Patrick

    2016-01-01

    Interpretation of magnetic and new gravity data provides constraints on the geometry of the Hat Creek Fault, the amount of right-lateral offset in the area between Mt. Shasta and Lassen Peak, and confirmation of the influence of pre-existing structure on Quaternary faulting. Neogene volcanic rocks coincide with short-wavelength magnetic anomalies of both normal and reversed polarity, whereas a markedly smoother magnetic field occurs over the Klamath Mountains and its Paleogene cover. Although the magnetic field over the Neogene volcanic rocks is complex, the Hat Creek Fault, which is one of the most prominent normal faults in the region and forms the eastern margin of the Hat Creek Valley, is marked by the eastern edge of a north-trending magnetic and gravity high 20-30 km long. Modeling of these anomalies indicates that the fault is a steeply dipping (~75-85°) structure. The spatial relationship of the fault as modeled by the potential-field data, the youngest strand of the fault, and relocated seismicity suggests that deformation continues to step westward across the valley, consistent with a component of right-lateral slip in an extensional environment. Filtered aeromagnetic data highlight a concealed magnetic body of Mesozoic or older age north of Hat Creek Valley. The body’s northwest margin strikes northeast and is linear over a distance of ~40 km. Within the resolution of the aeromagnetic data (1-2 km), we discern no right-lateral offset of this body. Furthermore, Quaternary faults change strike or appear to end, as if to avoid this concealed magnetic body and to pass along its southeast edge, suggesting that pre-existing crustal structure influenced younger faulting, as previously proposed based on gravity data.

  3. Design and evaluation of a foam-filled hat-stiffened panel concept for aircraft primary structural applications

    Science.gov (United States)

    Ambur, Damodar R.

    1995-01-01

    A structurally efficient hat-stiffened panel concept that utilizes a structural foam as stiffener core has been designed for aircraft primary structural applications. This stiffener concept utilizes a manufacturing process that can be adapted readily to grid-stiffened structural configurations which possess inherent damage tolerance characteristics due to their multiplicity of load paths. The foam-filled hat-stiffener concept in a prismatically stiffened panel configuration is more efficient than most other stiffened panel configurations in a load range that is typical for both fuselage and wing structures. The prismatically stiffened panel concept investigated here has been designed using AS4/3502 preimpregnated tape and Rohacell foam core and evaluated for its buckling and postbuckling behavior with and without low-speed impact damage. The results from single-stiffener and multi-stiffener specimens suggest that this structural concept responds to loading as anticipated and has good damage tolerance characteristics.

  4. Three Point Bending of Top-Hat Stiffened Chopped Short Fibre Ramie/HDPE Thermoplastic Composite Beam

    Science.gov (United States)

    Hadi, Bambang K.; Nuril, Yogie S.

    2018-04-01

    The use of natural fibre and thermoplastic matrices in composite materials increased significantly during the last decade especially in the automotive industries. Ramie is one of these potential natural fibres. In this paper, a three point bending of top-hat beam made of ramie/HDPE (High-Density-Polyethylene) composites was performed. Top-hat stiffened structures were common structures found in the aerospace industries. Nevertheless, these structures are beginning to be applied in automotive structures in the forms of chassis and bumpers. The ramie/HDPE composite was manufactured using hot-press technique. The temperature was set to be 135°C and the pressure was 6 bars. Chopped short ramie fibre was used, due to good drape ability characteristics. The experiments showed that the beams produced a large non-linearity. Linear Finite Element Analysis was carried out to be compared with the experimental data. The differences are reasonable.

  5. Sampling of BTX in Hat Yai city using cost effective laboratory-built PCB passive sampler.

    Science.gov (United States)

    Subba, Jas Raj; Thammakhet, Chongdee; Thavarungkul, Panote; Kanatharana, Proespichaya

    2016-08-23

    A laboratory-built printed circuit board (PCB) passive sampler used for the monitoring of xylene and styrene in copy print shops was re-validated for detecting benzene, toluene and xylene (BTX) and applied for the sampling of ambient air from Hat Yai city, Songkhla, Thailand, in the month of November 2014. For monitoring, the PCB passive samplers were exposed to target analytes in 16 locations covering high to low exposure areas. After sampling, the samplers were thermally desorbed and the analytes were trapped by multi-walled carbon nanotubes packed into a micro-preconcentrator coupled to a gas chromatograph (GC) equipped with a flame ionization detector. At the optimum GC operating conditions, the linear dynamic ranges for BTX were 0.06-5.6 µg for benzene, 0.07-2.2 µg for toluene and 0.23-2.5 µg for xylene with R(2) > 0.99 with the limits of detection being 6.6, 6.8 and 19 ng for benzene, toluene and xylene, respectively. The concentrations of BTX in the 16 sampling sites were in the range of N.D.-1.3 ± 1.6, 4.50 ± 0.76-49.6 ± 3.7 and 1.00 ± 0.21-39.6 ± 3.1 µg m(-3), respectively. When compared to past studies, there had been an increase in the benzene concentration.

  6. Bayesian estimation inherent in a Mexican-hat-type neural network

    Science.gov (United States)

    Takiyama, Ken

    2016-05-01

    Brain functions, such as perception, motor control and learning, and decision making, have been explained based on a Bayesian framework, i.e., to decrease the effects of noise inherent in the human nervous system or external environment, our brain integrates sensory and a priori information in a Bayesian optimal manner. However, it remains unclear how Bayesian computations are implemented in the brain. Herein, I address this issue by analyzing a Mexican-hat-type neural network, which was used as a model of the visual cortex, motor cortex, and prefrontal cortex. I analytically demonstrate that the dynamics of an order parameter in the model corresponds exactly to a variational inference of a linear Gaussian state-space model, a Bayesian estimation, when the strength of recurrent synaptic connectivity is appropriately stronger than that of an external stimulus, a plausible condition in the brain. This exact correspondence can reveal the relationship between the parameters in the Bayesian estimation and those in the neural network, providing insight for understanding brain functions.

  7. Hospital Acquired Thrombosis (HAT) Prevention in an Acute Hospital; A Single Centre Cross-Sectional Study

    LENUS (Irish Health Repository)

    Khan, MI

    2017-04-01

    Evidence based guidelines are effective in reducing incidence of venous thromboembolism (VTE) which is associated with morbidly, mortality and economic burden. This study aimed to identify the proportion of inpatients who had a VTE risk assessment (RA) performed and who received thromboprophylaxis (TP), in Cork University Hospital. There was no structured RA tool at the time; information was obtained from medical and drug charts to ascertain if a RA was performed. Patients were then RA by researchers and stratified as per NICE guidelines and the proportion who received TP was calculated. One thousand and nineteen inpatients were screened. Risk was documented in 24% of cases. TP was prescribed in 43.2% of inpatients. Following application of a RA tool >80% were at high risk of VTE with low risk of bleeding with TP prescription in 46.3% of inpatients. A national collaborative effort should be encouraged to develop a standardized approach for safe RA of inpatients and prescription of TP for prevention of HAT

  8. Effects of metric hierarchy and rhyme predictability on word duration in The Cat in the Hat.

    Science.gov (United States)

    Breen, Mara

    2018-05-01

    Word durations convey many types of linguistic information, including intrinsic lexical features like length and frequency and contextual features like syntactic and semantic structure. The current study was designed to investigate whether hierarchical metric structure and rhyme predictability account for durational variation over and above other features in productions of a rhyming, metrically-regular children's book: The Cat in the Hat (Dr. Seuss, 1957). One-syllable word durations and inter-onset intervals were modeled as functions of segment number, lexical frequency, word class, syntactic structure, repetition, and font emphasis. Consistent with prior work, factors predicting longer word durations and inter-onset intervals included more phonemes, lower frequency, first mention, alignment with a syntactic boundary, and capitalization. A model parameter corresponding to metric grid height improved model fit of word durations and inter-onset intervals. Specifically, speakers realized five levels of metric hierarchy with inter-onset intervals such that interval duration increased linearly with increased height in the metric hierarchy. Conversely, speakers realized only three levels of metric hierarchy with word duration, demonstrating that they shortened the highly predictable rhyme resolutions. These results further understanding of the factors that affect spoken word duration, and demonstrate the myriad cues that children receive about linguistic structure from nursery rhymes. Copyright © 2018 Elsevier B.V. All rights reserved.

  9. Synchrony, waves and ripple in spatially coupled Kuramoto oscillators with Mexican hat connectivity.

    Science.gov (United States)

    Heitmann, Stewart; Ermentrout, G Bard

    2015-06-01

    Spatiotemporal waves of synchronized activity are known to arise in oscillatory neural networks with lateral inhibitory coupling. How such patterns respond to dynamic changes in coupling strength is largely unexplored. The present study uses analysis and simulation to investigate the evolution of wave patterns when the strength of lateral inhibition is varied dynamically. Neural synchronization was modeled by a spatial ring of Kuramoto oscillators with Mexican hat lateral coupling. Broad bands of coexisting stable wave solutions were observed at all levels of inhibition. The stability of these waves was formally analyzed in both the infinite ring and the finite ring. The broad range of multi-stability predicted hysteresis in transitions between neighboring wave solutions when inhibition is slowly varied. Numerical simulation confirmed the predicted transitions when inhibition was ramped down from a high initial value. However, non-wave solutions emerged from the uniform solution when inhibition was ramped upward from zero. These solutions correspond to spatially periodic deviations of phase that we call ripple states. Numerical continuation showed that stable ripple states emerge from synchrony via a supercritical pitchfork bifurcation. The normal form of this bifurcation was derived analytically, and its predictions compared against the numerical results. Ripple states were also found to bifurcate from wave solutions, but these were locally unstable. Simulation also confirmed the existence of hysteresis and ripple states in two spatial dimensions. Our findings show that spatial synchronization patterns can remain structurally stable despite substantial changes in network connectivity.

  10. The HAT Score-A Simple Risk Stratification Score for Coagulopathic Bleeding During Adult Extracorporeal Membrane Oxygenation.

    Science.gov (United States)

    Lonergan, Terence; Herr, Daniel; Kon, Zachary; Menaker, Jay; Rector, Raymond; Tanaka, Kenichi; Mazzeffi, Michael

    2017-06-01

    The study objective was to create an adult extracorporeal membrane oxygenation (ECMO) coagulopathic bleeding risk score. Secondary analysis was performed on an existing retrospective cohort. Pre-ECMO variables were tested for association with coagulopathic bleeding, and those with the strongest association were included in a multivariable model. Using this model, a risk stratification score was created. The score's utility was validated by comparing bleeding and transfusion rates between score levels. Bleeding also was examined after stratifying by nadir platelet count and overanticoagulation. Predictive power of the score was compared against the risk score for major bleeding during anti-coagulation for atrial fibrillation (HAS-BLED). Tertiary care academic medical center. The study comprised patients who received venoarterial or venovenous ECMO over a 3-year period, excluding those with an identified source of surgical bleeding during exploration. None. Fifty-three (47.3%) of 112 patients experienced coagulopathic bleeding. A 3-variable score-hypertension, age greater than 65, and ECMO type (HAT)-had fair predictive value (area under the receiver operating characteristic curve [AUC] = 0.66) and was superior to HAS-BLED (AUC = 0.64). As the HAT score increased from 0 to 3, bleeding rates also increased as follows: 30.8%, 48.7%, 63.0%, and 71.4%, respectively. Platelet and fresh frozen plasma transfusion tended to increase with the HAT score, but red blood cell transfusion did not. Nadir platelet count less than 50×10 3 /µL and overanticoagulation during ECMO increased the AUC for the model to 0.73, suggesting additive risk. The HAT score may allow for bleeding risk stratification in adult ECMO patients. Future studies in larger cohorts are necessary to confirm these findings. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. HATS-36b and 24 Other Transiting/Eclipsing Systems from the HATSouth-K2 Campaign 7 Program

    Science.gov (United States)

    Bayliss, D.; Hartman, J. D.; Zhou, G.; Bakos, G. Á.; Vanderburg, A.; Bento, J.; Mancini, L.; Ciceri, S.; Brahm, R.; Jordán, A.; Espinoza, N.; Rabus, M.; Tan, T. G.; Penev, K.; Bhatti, W.; de Val-Borro, M.; Suc, V.; Csubry, Z.; Henning, Th.; Sarkis, P.; Lázár, J.; Papp, I.; Sári, P.

    2018-03-01

    We report on the result of a campaign to monitor 25 HATSouth candidates using the Kepler space telescope during Campaign 7 of the K2 mission. We discover HATS-36b (EPIC 215969174b, K2-145b), an eccentric (e=0.105+/- 0.028) hot Jupiter with a mass of 3.216+/- 0.062 {M}{{J}} and a radius of 1.235+/- 0.043 {R}{{J}}, which transits a solar-type G0V star (V = 14.386) in a 4.1752-day period. We also refine the properties of three previously discovered HATSouth transiting planets (HATS-9b, HATS-11b, and HATS-12b) and search the K2 data for TTVs and additional transiting planets in these systems. In addition, we also report on a further three systems that remain as Jupiter-radius transiting exoplanet candidates. These candidates do not have determined masses, however pass all of our other vetting observations. Finally, we report on the 18 candidates that we are now able to classify as eclipsing binary or blended eclipsing binary systems based on a combination of the HATSouth data, the K2 data, and follow-up ground-based photometry and spectroscopy. These range in periods from 0.7 day to 16.7 days, and down to 1.5 mmag in eclipse depths. Our results show the power of combining ground-based imaging and spectroscopy with higher precision space-based photometry, and serve as an illustration as to what will be possible when combining ground-based observations with TESS data.

  12. Ideologiekritik des E-Learnings. Welchen Nutzen hat die Einführung von E-Learning?

    Directory of Open Access Journals (Sweden)

    Katharina Kaiser-Müller

    2015-03-01

    Full Text Available Vor etwa sieben Jahren hat das damalige Bundesministerium für Unterricht, Kunst und Kultur (bm:ukk, das seit 2014 Bundesministerium für Bildung und Frauen (BMBF genannt wird, verschiedene Maßnahmen im Blick auf neuen Medien – insbesondere im Blick auf das E-Learning – gesetzt, um einen Beitrag zur Vorbereitung der Lernenden auf eine Informations- und Wissensgesellschaft zu leisten. E-Learning wurde als Erfolgsfaktor für die Zukunft gesehen und mit der Begründung, es fördere das individuelle und selbst gesteuerte Lernen, gefördert. Die zentrale Frage ist dabei: Welchen Nutzen hat die Einführung von E-Learning? In diesem Artikel wird dahingehend aufgezeigt, dass E-Learning nicht wegen pädagogischem Bedarf, sondern durch ministeriell gesetzte Maßnahmen eingeführt wurde und dadurch – wenn auch nicht bewusst und schon gar nicht als solches kommuniziert – neoliberale Strukturen durchgesetzt wurden. Die Einführung von E-Learning hat somit für deren Akzeptanz gesorgt.

  13. HAT-P-11b: A SUPER-NEPTUNE PLANET TRANSITING A BRIGHT K STAR IN THE KEPLER FIELD

    International Nuclear Information System (INIS)

    Bakos, G. A.; Torres, G.; Pal, A.; Hartman, J.; Noyes, R. W.; Latham, D. W.; Sasselov, D. D.; Sipocz, B.; Esquerdo, G. A.; Kovacs, Gabor; Fernandez, J.; Kovacs, Geza; Moor, A.; Fischer, D. A.; Isaacson, H.; Johnson, J. A.; Marcy, G. W.; Howard, A.; Butler, R. P.; Vogt, S.

    2010-01-01

    We report on the discovery of HAT-P-11b, the smallest radius transiting extrasolar planet (TEP) discovered from the ground, and the first hot Neptune discovered to date by transit searches. HAT-P-11b orbits the bright (V = 9.587) and metal rich ([Fe/H] = +0.31 ± 0.05) K4 dwarf star GSC 03561-02092 with P = 4.8878162 ± 0.0000071 days and produces a transit signal with depth of 4.2 mmag, the shallowest found by transit searches that is due to a confirmed planet. We present a global analysis of the available photometric and radial velocity (RV) data that result in stellar and planetary parameters, with simultaneous treatment of systematic variations. The planet, like its near-twin GJ 436b, is somewhat larger than Neptune (17 M + , 3.8 R + ) both in mass M p = 0.081 ± 0.009 M J (25.8 ± 2.9 M + ) and radius R p = 0.422 ± 0.014 R J (4.73 ± 0.16 R + ). HAT-P-11b orbits in an eccentric orbit with e = 0.198 ± 0.046 and ω = 355. 0 2 ± 17. 0 3, causing a reflex motion of its parent star with amplitude 11.6 ± 1.2 m s -1 , a challenging detection due to the high level of chromospheric activity of the parent star. Our ephemeris for the transit events is T c = 2454605.89132 ± 0.00032 (BJD), with duration 0.0957 ± 0.0012 days, and secondary eclipse epoch of 2454608.96 ± 0.15 days (BJD). The basic stellar parameters of the host star are M * = 0.809 +0.020 -0.027 M sun , R * = 0.752 ± 0.021 R sun , and T eff* = 4780 ± 50 K. Importantly, HAT-P-11 will lie on one of the detectors of the forthcoming Kepler mission; this should make possible fruitful investigations of the detailed physical characteristic of both the planet and its parent star at unprecedented precision. We discuss an interesting constraint on the eccentricity of the system by the transit light curve and stellar parameters. This will be particularly useful for eccentric TEPs with low-amplitude RV variations in Kepler's field. We also present a blend analysis, that for the first time treats the case of a

  14. Numerical simulation on chain-die forming of an AHSS top-hat section

    Science.gov (United States)

    Majji, Raju; Xiang, Yang; Ding, Scott; Yang, Chunhui

    2018-05-01

    The applications of Advanced High-Strength Steels (AHSS) in the automotive industry are rapidly increasing due to a demand for a lightweight material that significantly reduces fuel consumption without compromising passenger safety. Automotive industries and material suppliers are expected by consumers to deliver reliable and affordable products, thus stimulating these manufacturers to research solutions to meet these customer requirements. The primary advantage of AHSS is its extremely high strength to weight ratio, an ideal material for the automotive industry. However, its low ductility is a major disadvantage, in particular, when using traditional cold forming processes such as roll forming and deep drawing process to form profiles. Consequently, AHSS parts frequently fail to form. Thereby, in order to improve quality and reliability on manufacturing AHSS products, a recently-developed incremental cold sheet metal forming technology called Chain-die Forming (CDF) is recognised as a potential solution to the forming process of AHSS. The typical CDF process is a combination of bending and roll forming processes which is equivalent to a roll with a large deforming radius, and incrementally forms the desired shape with split die and segments. This study focuses on manufacturing an AHSS top-hat section with minimum passes without geometrical or surface defects by using finite element modelling and simulations. The developed numerical simulation is employed to investigate the influences on the main control parameter of the CDF process while forming AHSS products and further develop new die-punch sets of compensation design via a numerical optimal process. In addition, the study focuses on the tool design to compensate spring-back and reduce friction between tooling and sheet-metal. This reduces the number of passes, thereby improving productivity and reducing energy consumption and material waste. This numerical study reveals that CDF forms AHSS products of complex

  15. Groundwater evolution beneath Hat Yai, a rapidly developing city in Thailand

    Science.gov (United States)

    Lawrence, A. R.; Gooddy, D. C.; Kanatharana, P.; Meesilp, W.; Ramnarong, V.

    2000-09-01

    Many cities and towns in South and Southeast Asia are unsewered, and urban wastewaters are often discharged either directly to the ground or to surface-water canals and channels. This practice can result in widespread contamination of the shallow groundwater. In Hat Yai, southern Thailand, seepage of urban wastewaters has produced substantial deterioration in the quality of the shallow groundwater directly beneath the city. For this reason, the majority of the potable water supply is obtained from groundwater in deeper semi-confined aquifers 30-50 m below the surface. However, downward leakage of shallow groundwater from beneath the city is a significant component of recharge to the deeper aquifer, which has long-term implications for water quality. Results from cored boreholes and shallow nested piezometers are presented. The combination of high organic content of the urban recharge and the shallow depth to the water table has produced strongly reducing conditions in the upper layer and the mobilisation of arsenic. A simple analytical model shows that time scales for downward leakage, from the surface through the upper aquitard to the semi-confined aquifer, are of the order of several decades. Résumé. De nombreuses villes du sud et du sud-est de l'Asie ne possèdent pas de réseaux d'égouts et les eaux usées domestiques s'écoulent souvent directement sur le sol ou dans des canaux et des cours d'eau de surface. Ces pratiques peuvent provoquer une contamination dispersée de la nappe phréatique. A Hat Yai (sud de la Thaïlande), les infiltrations d'eaux usées domestiques sont responsables d'une détérioration notable de la qualité de la nappe phréatique directement sous la ville. Pour cette raison, la majorité de l'eau potable est prélevée dans des aquifères semi-captifs plus profonds, situés entre 30 et 50 m sous la surface. Cependant, une drainance à partir de la nappe phréatique sous la ville constitue une composante significative de la recharge

  16. Assessment of efficiency of water supply system in Prince of Songkla University, Hat Yai Campus

    Directory of Open Access Journals (Sweden)

    Chaivisit, P.

    2007-03-01

    Full Text Available Assessment of efficiency of water production system in Prince of Songkla University, Hat Yai Campus, was conducted in this study. Topics covered include 1 quality and quantity of raw water, 2 water productionprocess, 3 management and maintenance of water production system, and 4 quality of finished water. Totally, 494 water samples were collected during the study. All water samples were analyzed for turbidity,pH, temperature, conductivity, TDS, total coliforms, fecal coliforms and residual chlorine. In addition to the mentioned parameters, 30 of these water samples were also analyzed for hardness, chloride, nitratenitrogen,sulfate and heavy metals (manganese, copper, zinc, iron, chromium, cadmium, lead and mercury. All water samples were collected during November, 2004 (rainy season and March, 2005 (summer season.It was found that the quality of the water in the Sritrang reservoir fell into Class 2 of Thailand Surface Water Quality Standard that requires ordinary water treatment processes prior to consumptions.Cadmium, lead and mercury were not detected by Inductively Coupled Plasma (ICP method. There are 2 sets of water production system. The first set consists of 4 pressure filters which could reduce turbidity atvarying efficiencies: 33.83%, 18.26%, 42.76% and 65.67% depending mainly on the extent of chemical dosing control and the maintenance of the filter media. Another system employed sedimentation tank andrapid sand filter, which could remove turbidity at 89.28%. When combined finished water from both systems were analyzed, it was found that removals of manganese, copper, zinc, iron and chromium were 42.65%,30.02%, 19.54%, 56.82% and 15.12%, respectively. Residual chlorine concentration of the finished water was not more than 0.2 mg/L and no total coliforms or fecal coliforms were detected. The plant had sufficientand competent personnel to carry out their normal tasks but occasional negligence and lack of specific water testing or

  17. Treatment efficiency in wastewater treatment plant of Hat Yai Municipality by quantitative removal of microbial indicators

    Directory of Open Access Journals (Sweden)

    Duangporn Kantachote

    2009-11-01

    Full Text Available The efficiency of treatment in a wastewater treatment plant of Hat Yai Municipality through stabilization ponds and constructed wetlands was monitored by using the bacterial indicators, total coliforms (TC, fecal coliforms (FC, Escherichia coli and fecal streptococci (FS, and photosynthetic microbes. The sequence of water flow in the wastewater treatment plant is as follows: primary or anaerobic pond (P, facultative pond (F, maturation pond (M, constructed wetlands (W1, W2 and W3, and an effluent storage pond (S for the treated wastewater. The wastewater treatment plant has an approximate area of 3,264,000 m2 (2,040 rai and its dry weather flow was running at only 40,000 m3/ day. There were 10 sampling times used for all the 7 ponds during July-October, 2006.Statistical analysis using a Two-Factorial Design model, indicated that pond types significantly affected temperature, dissolved oxygen (DO, and pH (p<0.05, whereas the time of sampling during the day had a significant effect (p<0.05 only on the temperature and light intensity available to the ponds. There were also significant different removal efficiencies of the different bacterial indicator groups tested (p<0.05. The overall performance of the wastewater treatment plant effectively removed TC, FC, E. coli, and FS as follows, 99.8%, 99.8%, 75.8% and 98.8%, respectively. The amounts of bacterial indicators, except for E. coli, showed a negative correlation with levels of light intensity and DO, whereas there was no correlation between the pH and the different indicator bacteria. There was a positive middle level correlation between pHand chlorophyll a.There were five different divisions of photosynthetic organisms detected throughout the plant as follows, Cyanophyta, Chlorophyta, Bacillariophyta, Euglenophyta, and Pyrrhophyta. The least diversity was found in the anaerobic pond (P as there were only 15 genera. Euglena, an indicator of dirty water, was detected only in this pond. The

  18. Point source detection using the Spherical Mexican Hat Wavelet on simulated all-sky Planck maps

    Science.gov (United States)

    Vielva, P.; Martínez-González, E.; Gallegos, J. E.; Toffolatti, L.; Sanz, J. L.

    2003-09-01

    We present an estimation of the point source (PS) catalogue that could be extracted from the forthcoming ESA Planck mission data. We have applied the Spherical Mexican Hat Wavelet (SMHW) to simulated all-sky maps that include cosmic microwave background (CMB), Galactic emission (thermal dust, free-free and synchrotron), thermal Sunyaev-Zel'dovich effect and PS emission, as well as instrumental white noise. This work is an extension of the one presented in Vielva et al. We have developed an algorithm focused on a fast local optimal scale determination, that is crucial to achieve a PS catalogue with a large number of detections and a low flux limit. An important effort has been also done to reduce the CPU time processor for spherical harmonic transformation, in order to perform the PS detection in a reasonable time. The presented algorithm is able to provide a PS catalogue above fluxes: 0.48 Jy (857 GHz), 0.49 Jy (545 GHz), 0.18 Jy (353 GHz), 0.12 Jy (217 GHz), 0.13 Jy (143 GHz), 0.16 Jy (100 GHz HFI), 0.19 Jy (100 GHz LFI), 0.24 Jy (70 GHz), 0.25 Jy (44 GHz) and 0.23 Jy (30 GHz). We detect around 27 700 PS at the highest frequency Planck channel and 2900 at the 30-GHz one. The completeness level are: 70 per cent (857 GHz), 75 per cent (545 GHz), 70 per cent (353 GHz), 80 per cent (217 GHz), 90 per cent (143 GHz), 85 per cent (100 GHz HFI), 80 per cent (100 GHz LFI), 80 per cent (70 GHz), 85 per cent (44 GHz) and 80 per cent (30 GHz). In addition, we can find several PS at different channels, allowing the study of the spectral behaviour and the physical processes acting on them. We also present the basic procedure to apply the method in maps convolved with asymmetric beams. The algorithm takes ~72 h for the most CPU time-demanding channel (857 GHz) in a Compaq HPC320 (Alpha EV68 1-GHz processor) and requires 4 GB of RAM memory; the CPU time goes as O[NRoN3/2pix log(Npix)], where Npix is the number of pixels in the map and NRo is the number of optimal scales needed.

  19. Possible detection of a bimodal cloud distribution in the atmosphere of HAT-P-32 A b from multiband photometry

    Science.gov (United States)

    Tregloan-Reed, J.; Southworth, J.; Mancini, L.; Mollière, P.; Ciceri, S.; Bruni, I.; Ricci, D.; Ayala-Loera, C.; Henning, T.

    2018-03-01

    We present high-precision photometry of eight separate transit events in the HAT-P-32 planetary system. One transit event was observed simultaneously by two telescopes of which one obtained a simultaneous multiband light curve in three optical bands, giving a total of 11 transit light curves. Due to the filter selection and in conjunction with using the defocused photometry technique, we were able to obtain an extremely high-precision, ground-based transit in the u band (350 nm), with an rms scatter of ≈1 mmag. All 11 transits were modelled using PRISM and GEMC, and the physical properties of the system calculated. We find the mass and radius of the host star to be 1.182 ± 0.041 M⊙ and 1.225 ± 0.015 R⊙, respectively. For the planet, we find a mass of 0.80 ± 0.14 MJup, a radius of 1.807 ± 0.022 RJup, and a density of 0.126 ± 0.023 ρJup. These values are consistent with those found in the literature. We also obtain a new orbital ephemeris for the system T0 = BJD/TDB 2 454 420.447187(96) + 2.15000800(10) × E. We measured the transmission spectrum of HAT-P-32 A b and compared it to theoretical transmission spectra. Our results indicate a bimodal cloud particle distribution consisting of Rayleigh-like haze and grey absorbing cloud particles within the atmosphere of HAT-P-32 A b.

  20. An Algorithm of Building Extraction in Urban Area Based on Improved Top-hat Transformations and LBP Elevation Texture

    Directory of Open Access Journals (Sweden)

    HE Manyun

    2017-09-01

    Full Text Available Classification of building and vegetation is difficult solely by LiDAR data and vegetation in shadows can't be eliminated only by aerial images. The improved top-hat transformations and local binary patterns (LBP elevation texture analysis for building extraction are proposed based on the fusion of aerial images and LiDAR data. Firstly, LiDAR data is reorganized into grid cell, the algorithm removes ground points through top-hat transform. Then, the vegetation points are extracted by normalized difference vegetation index (NDVI. Thirdly, according to the elevation information of LiDAR points, LBP elevation texture is calculated and achieving precise elimination of vegetation in shadows or surrounding to the buildings. At last, morphological operations are used to fill the holes of building roofs, and region growing for complete building edges. The simulation is based on the complex urban area in Vaihingen benchmark provided by ISPRS, the results show that the algorithm affording higher classification accuracy.

  1. ANALYSIS OF SPIN-ORBIT ALIGNMENT IN THE WASP-32, WASP-38, AND HAT-P-27/WASP-40 SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Brown, D. J. A.; Collier Cameron, A.; Enoch, B.; Miller, G. R. M. [SUPA, School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews, Fife KY16 9SS (United Kingdom); Diaz, R. F. [LAM (Laboratoire d' Astrophysique de Marseille), Aix Marseille Universite, CNRS, UMR 7326, F-13388 Marseille (France); Doyle, A. P.; Smalley, B.; Anderson, D. R.; Hellier, C.; Maxted, P. F. L. [Astrophysics Group, School of Physical and Geographical Sciences, Lennard-Jones Building, Keele University, Staffordshire ST5 5BG (United Kingdom); Gillon, M. [Institut d' Astrophysique et de Geophysique, Universite de Liege, Allee du 6 Aout, 17 (Bat. B5C) Sart Tilman, B-4000 Liege (Belgium); Lendl, M.; Triaud, A. H. M. J.; Queloz, D. [Observatoire Astronomique de l' Universite de Geneve, 51 Chemin des Maillettes, CH-1290 Sauverny (Switzerland); Pollacco, D. [Astrophysics Research Centre, School of Mathematics and Physics, Queen' s University, University Road, Belfast BT7 1NN (United Kingdom); Boisse, I. [Centro de Astrofisica, Universidade do Porto, Rua das Estrelas, 4150-762 Porto (Portugal); Hebrard, G., E-mail: djab@st-andrews.ac.uk [Institut dAstrophysique de Paris, UMR7095 CNRS, Universite Pierre and Marie Curie, 98bis boulevard Arago, F-75014 Paris (France)

    2012-12-01

    We present measurements of the spin-orbit alignment angle, {lambda}, for the hot Jupiter systems WASP-32, WASP-38, and HAT-P-27/WASP-40, based on data obtained using the HARPS spectrograph. We analyze the Rossiter-McLaughlin effect for all three systems and also carry out Doppler tomography for WASP-32 and WASP-38. We find that WASP-32 (T {sub eff} = 6140{sup +90} {sub -100} K) is aligned, with an alignment angle of {lambda} = 10.{sup 0}5{sup +6.4} {sub -6.5} obtained through tomography, and that WASP-38 (T {sub eff} = 6180{sup +40} {sub -60} K) is also aligned, with tomographic analysis yielding {lambda} = 7.{sup 0}5{sup +4.7} {sub -6.1}. The latter result provides an order-of-magnitude improvement in the uncertainty in {lambda} compared to the previous analysis of Simpson et al. We are only able to loosely constrain the angle for HAT-P-27/WASP-40 (T{sub eff} = 5190{sup +160} {sub -170} K) to {lambda} = 24.{sup 0}2{sup +76.0}{sub -44.5}, owing to the poor signal-to-noise ratio of our data. We consider this result a non-detection under a slightly updated version of the alignment test of Brown et al. We place our results in the context of the full sample of spin-orbit alignment measurements, finding that they provide further support for previously established trends.

  2. ATMOSPHERE AND SPECTRAL MODELS OF THE KEPLER-FIELD PLANETS HAT-P-7b AND TrES-2

    International Nuclear Information System (INIS)

    Spiegel, David S.; Burrows, Adam

    2010-01-01

    We develop atmosphere models of two of the three Kepler-field planets that were known prior to the start of the Kepler mission (HAT-P-7b and TrES-2). We find that published Kepler and Spitzer data for HAT-P-7b appear to require an extremely hot upper atmosphere on the dayside, with a strong thermal inversion and little day-night redistribution. The Spitzer data for TrES-2 suggest a mild thermal inversion with moderate day-night redistribution. We examine the effect of nonequilibrium chemistry on TrES-2 model atmospheres and find that methane levels must be adjusted by extreme amounts in order to cause even mild changes in atmospheric structure and emergent spectra. Our best-fit models to the Spitzer data for TrES-2 lead us to predict a low secondary eclipse planet-star flux ratio (∼ -5 ) in the Kepler bandpass, which is consistent with what very recent observations have found. Finally, we consider how the Kepler-band optical flux from a hot exoplanet depends on the strength of a possible extra optical absorber in the upper atmosphere. We find that the optical flux is not monotonic in optical opacity, and the non-monotonicity is greater for brighter, hotter stars.

  3. Structural basis of hAT transposon end recognition by Hermes, an octameric DNA transposase from Musca domestica.

    Science.gov (United States)

    Hickman, Alison B; Ewis, Hosam E; Li, Xianghong; Knapp, Joshua A; Laver, Thomas; Doss, Anna-Louise; Tolun, Gökhan; Steven, Alasdair C; Grishaev, Alexander; Bax, Ad; Atkinson, Peter W; Craig, Nancy L; Dyda, Fred

    2014-07-17

    Hermes is a member of the hAT transposon superfamily that has active representatives, including McClintock's archetypal Ac mobile genetic element, in many eukaryotic species. The crystal structure of the Hermes transposase-DNA complex reveals that Hermes forms an octameric ring organized as a tetramer of dimers. Although isolated dimers are active in vitro for all the chemical steps of transposition, only octamers are active in vivo. The octamer can provide not only multiple specific DNA-binding domains to recognize repeated subterminal sequences within the transposon ends, which are important for activity, but also multiple nonspecific DNA binding surfaces for target capture. The unusual assembly explains the basis of bipartite DNA recognition at hAT transposon ends, provides a rationale for transposon end asymmetry, and suggests how the avidity provided by multiple sites of interaction could allow a transposase to locate its transposon ends amidst a sea of chromosomal DNA. Copyright © 2014 Elsevier Inc. All rights reserved.

  4. A SEARCH FOR WATER IN THE ATMOSPHERE OF HAT-P-26b USING LDSS-3C

    Energy Technology Data Exchange (ETDEWEB)

    Stevenson, Kevin B.; Bean, Jacob L.; Seifahrt, Andreas; Gilbert, Gregory J. [Department of Astronomy and Astrophysics, University of Chicago, 5640 S Ellis Avenue, Chicago, IL 60637 (United States); Line, Michael R. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Désert, Jean-Michel [Anton Pannekoek Institute for Astronomy, University of Amsterdam, Amsterdam (Netherlands); Fortney, Jonathan J., E-mail: kbs@uchicago.edu [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States)

    2016-02-01

    The characterization of a physically diverse set of transiting exoplanets is an important and necessary step toward establishing the physical properties linked to the production of obscuring clouds or hazes. It is those planets with identifiable spectroscopic features that can most effectively enhance our understanding of atmospheric chemistry and metallicity. The newly commissioned LDSS-3C instrument on Magellan provides enhanced sensitivity and suppressed fringing in the red optical, thus advancing the search for the spectroscopic signature of water in exoplanetary atmospheres from the ground. Using data acquired by LDSS-3C and the Spitzer Space Telescope, we search for evidence of water vapor in the transmission spectrum of the Neptune-mass planet HAT-P-26b. Our measured spectrum is best explained by the presence of water vapor, a lack of potassium, and either a high-metallicity, cloud-free atmosphere or a solar-metallicity atmosphere with a cloud deck at ∼10 mbar. The emergence of multi-scale-height spectral features in our data suggests that future observations at higher precision could break this degeneracy and reveal the planet’s atmospheric chemical abundances. We also update HAT-P-26b’s transit ephemeris, t{sub 0} = 2455304.65218(25) BJD{sub TDB}, and orbital period, p = 4.2345023(7) days.

  5. H4 replication-dependent diacetylation and Hat1 promote S-phase chromatin assembly in vivo

    Science.gov (United States)

    Ejlassi-Lassallette, Aïda; Mocquard, Eloïse; Arnaud, Marie-Claire; Thiriet, Christophe

    2011-01-01

    While specific posttranslational modification patterns within the H3 and H4 tail domains are associated with the S-phase, their actual functions in replication-dependent chromatin assembly have not yet been defined. Here we used incorporation of trace amounts of recombinant proteins into naturally synchronous macroplasmodia of Physarum polycephalum to examine the function of H3 and H4 tail domains in replication-coupled chromatin assembly. We found that the H3/H4 complex lacking the H4 tail domain was not efficiently recovered in nuclei, whereas depletion of the H3 tail domain did not impede nuclear import but chromatin assembly failed. Furthermore, our results revealed that the proper pattern of acetylation on the H4 tail domain is required for nuclear import and chromatin assembly. This is most likely due to binding of Hat1, as coimmunoprecipitation experiments showed Hat1 associated with predeposition histones in the cytoplasm and with replicating chromatin. These results suggest that the type B histone acetyltransferase assists in shuttling the H3/H4 complex from cytoplasm to the replication forks. PMID:21118997

  6. Transiting Exoplanet Monitoring Project (TEMP). II. Refined System Parameters and Transit Timing Analysis of HAT-P-33b

    Science.gov (United States)

    Wang, Yong-Hao; Wang, Songhu; Liu, Hui-Gen; Hinse, Tobias C.; Laughlin, Gregory; Wu, Dong-Hong; Zhang, Xiaojia; Zhou, Xu; Wu, Zhenyu; Zhou, Ji-Lin; Wittenmyer, R. A.; Eastman, Jason; Zhang, Hui; Hori, Yasunori; Narita, Norio; Chen, Yuanyuan; Ma, Jun; Peng, Xiyan; Zhang, Tian-Meng; Zou, Hu; Nie, Jun-Dan; Zhou, Zhi-Min

    2017-08-01

    We present 10 R-band photometric observations of eight different transits of the hot Jupiter HAT-P-33b, which has been targeted by our Transiting Exoplanet Monitoring Project. The data were obtained by two telescopes at the Xinglong Station of National Astronomical Observatories of China (NAOC) from 2013 December through 2016 January, and exhibit photometric scatter of 1.6{--}3.0 {mmag}. After jointly analyzing the previously published photometric data, radial-velocity (RV) measurements, and our new light curves, we revisit the system parameters and orbital ephemeris for the HAT-P-33b system. Our results are consistent with the published values except for the planet to star radius ratio ({R}{{P}}/{R}* ), the ingress/egress duration (τ) and the total duration (T 14), which together indicate a slightly shallower and shorter transit shape. Our results are based on more complete light curves, whereas the previously published work had only one complete transit light curve. No significant anomalies in Transit Timing Variations (TTVs) are found, and we place upper mass limits on potential perturbers, largely supplanting the loose constraints provided by the extant RV data. The TTV limits are stronger near mean-motion resonances, especially for the low-order commensurabilities. We can exclude the existence of a perturber with mass larger than 0.6, 0.3, 0.5, 0.5, and 0.3 {M}\\oplus near the 1:3, 1:2, 2:3, 3:2, and 2:1 resonances, respectively.

  7. En hat er vel en hat ... eller?

    DEFF Research Database (Denmark)

    Bøilerehauge, Dorrit

    2007-01-01

    Mens vi kører i høj fart på "the information highway" - i den helt store bus midt på vejen - glemmer vi ofte noget meget vigtigt i vores glæde over, at verden tilsyneladende åbner sig for os, og vi kan kommunikere med hele verden med ét klik. Vi glemmer, at selvom trafikskilte som oftest er ens -...... - så er selve trafikken og forventningerne blandt medtrafikanterne helt forskellige fra det, vi er vant til. Udgivelsesdato: Februar...

  8. Radiological audit of remedial action activities at the processing sites Mexican Hat, Utah and Monument Valley, Arizona. Audit date: May 3--7, 1993, Final report

    International Nuclear Information System (INIS)

    1993-05-01

    The Uranium Mill Tailings Remedial Action (UMTRA) Project's Technical Assistance Contractor (TAC) performed a radiological audit of the Remedial Action Contractor (RAC), MK-Ferguson and CWM Federal Environmental Services, Inc., at the processing sites in Mexican Hat, Utah, and Monument Valley, Arizona. This audit was conducted May 3--7, 1993, by Bill James and Gerry Simiele of the TAC. Three site-specific findings and four observations were identified during the audit and are presented in this report. The overall conclusion from the audit is that the majority of the radiological aspects of the Mexican Hat, Utah, and Monument Valley, Arizona, remedial action programs are performed adequately. However, the findings identify that there is some inconsistency in following procedures and meeting requirements for contamination control, and a lack of communication between the RAC and the DOE on variances from the published remedial action plan (RAP)

  9. Peak center and area estimation in gamma-ray energy spectra using a Mexican-hat wavelet

    Energy Technology Data Exchange (ETDEWEB)

    Qin, Zhang-jian; Chen, Chuan; Luo, Jun-song; Xie, Xing-hong; Ge, Liang-quan [School of Information Science & Technology, Chengdu University of Technology, Chengdu (China); Wu, Qi-fan [Department of Engineering Physics, Tsinghua University, Beijing (China)

    2017-06-21

    Wavelet analysis is commonly used to detect and localize peaks within a signal, such as in Gamma-ray energy spectra. This paper presents a peak area estimation method based on a new wavelet analysis. Another Mexican Hat Wavelet Signal (MHWS) named after the new MHWS is obtained with the convolution of a Gaussian signal and a MHWS. During the transform, the overlapping background on the Gaussian signal caused by Compton scattering can be subtracted because the impulse response function MHWS is a second-order smooth function, and the amplitude of the maximum within the new MHWS is the net height corresponding to the Gaussian signal height, which can be used to estimate the Gaussian peak area. Moreover, the zero-crossing points within the new MHWS contain the information of the Gaussian variance whose valve should be obtained when the Gaussian peak area is estimated. Further, the new MHWS center is also the Gaussian peak center. With that distinguishing feature, the channel address of a characteristic peak center can be accurately obtained which is very useful in the stabilization of airborne Gamma energy spectra. In particular, a method for determining the correction coefficient k is given, where the peak area is calculated inaccurately because the value of the scale factor in wavelet transform is too small. The simulation and practical applications show the feasibility of the proposed peak center and area estimation method.

  10. Two hAT transposon genes were transferred from Brassicaceae to broomrapes and are actively expressed in some recipients

    Science.gov (United States)

    Sun, Ting; Renner, Susanne S.; Xu, Yuxing; Qin, Yan; Wu, Jianqiang; Sun, Guiling

    2016-01-01

    A growing body of evidence is pointing to an important role of horizontal gene transfer (HGT) in the evolution of higher plants. However, reports of HGTs of transposable elements (TEs) in plants are still scarce, and only one case is known of a class II transposon horizontally transferred between grasses. To investigate possible TE transfers in dicots, we performed transcriptome screening in the obligate root parasite Phelipanche aegyptiaca (Orobanchaceae), data-mining in the draft genome assemblies of four other Orobanchaceae, gene cloning, gene annotation in species with genomic information, and a molecular phylogenetic analysis. We discovered that the broomrape genera Phelipanche and Orobanche acquired two related nuclear genes (christened BO transposase genes), a new group of the hAT superfamily of class II transposons, from Asian Sisymbrieae or a closely related tribe of Brassicaceae, by HGT. The collinearity of the flanking genes, lack of a classic border structure, and low expression levels suggest that BO transposase genes cannot transpose in Brassicaceae, whereas they are highly expressed in P. aegyptiaca. PMID:27452947

  11. Spatial and social factors associated with transportation and recreational physical activity among adults in Hat Yai City, Songkhla,Thailand.

    Science.gov (United States)

    Churangsarit, Saowaphan; Chongsuvivatwong, Virasakdi

    2011-08-01

    Transportation physical activity (TPA) and recreational physical activity (RPA) in an urban area can be sources of physical activity (PA) in addition to working. This study was conducted in Hat Yai City Municipality, the fourth most populous city in Thailand, to describe the magnitude of these physical activities and identify their associated factors. 369 adults were selected from a random sampling of registered households. Based on the Global Physical Activity Questionnaire (GPAQ), subjects were interviewed on their modes of TPA and RPA during the past week. Hurdle regression was used to examine predictors for having PA separately from predictor of intensity of PA among the active. Metabolic equivalent (MET) of TPA and RPA were computed. Prevalence of not having TPA and RPA were 71.3% and 45.8%, respectively. TPA and RPA contributed 1.5% and 9.2% of total PA. Active commuters were more common in females 40 or more years old, less sedentary persons, and those living near shopping places. Persons having RPA were more likely to be less sedentary, whereas the intensity of RPA was higher among single persons and males. TPA and RPA in this study area were uncommon. Further strategies are needed to improve the situation, especially among sedentary persons.

  12. Single step synthesis of gold-amino acid composite, with the evidence of the catalytic hydrogen atom transfer (HAT) reaction, for the electrochemical recognition of Serotonin

    Science.gov (United States)

    Choudhary, Meenakshi; Siwal, Samarjeet; Nandi, Debkumar; Mallick, Kaushik

    2016-03-01

    A composite architecture of amino acid and gold nanoparticles has been synthesized using a generic route of 'in-situ polymerization and composite formation (IPCF)' [1,2]. The formation mechanism of the composite has been supported by a model hydrogen atom (H•≡H++e-) transfer (HAT) type of reaction which belongs to the proton coupled electron transfer (PCET) mechanism. The 'gold-amino acid composite' was used as a catalyst for the electrochemical recognition of Serotonin.

  13. Warm Spitzer and Palomar near-IR secondary eclipse photometry of two hot Jupiters: WASP-48b and HAT-P-23b

    Energy Technology Data Exchange (ETDEWEB)

    O' Rourke, Joseph G.; Knutson, Heather A.; Désert, Jean-Michel [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Zhao, Ming [Department of Astronomy and Astrophysics, 525 Davey Laboratory, The Pennsylvania State University, University Park, PA 16802 (United States); Fortney, Jonathan J. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Burrows, Adam [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 05844 (United States); Agol, Eric [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Deming, Drake [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Howard, Andrew W. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Lewis, Nikole K. [Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Showman, Adam P. [Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721 (United States); Todorov, Kamen O. [Institute for Astronomy, ETH Zürich, Wolfgang-Pauli-Strasse 27, 8093 Zürich (Switzerland)

    2014-02-01

    We report secondary eclipse photometry of two hot Jupiters, WASP-48b and HAT-P-23b, at 3.6 and 4.5 μm taken with the InfraRed Array Camera aboard the Spitzer Space Telescope during the warm Spitzer mission and in the H and K{sub S} bands with the Wide Field IR Camera at the Palomar 200 inch Hale Telescope. WASP-48b and HAT-P-23b are Jupiter-mass and twice Jupiter-mass objects orbiting an old, slightly evolved F star and an early G dwarf star, respectively. In the H, K{sub S} , 3.6 μm, and 4.5 μm bands, respectively, we measure secondary eclipse depths of 0.047% ± 0.016%, 0.109% ± 0.027%, 0.176% ± 0.013%, and 0.214% ± 0.020% for WASP-48b. In the K{sub S} , 3.6 μm, and 4.5 μm bands, respectively, we measure secondary eclipse depths of 0.234% ± 0.046%, 0.248% ± 0.019%, and 0.309% ± 0.026% for HAT-P-23b. For WASP-48b and HAT-P-23b, respectively, we measure delays of 2.6 ± 3.9 minutes and 4.0 ± 2.4 minutes relative to the predicted times of secondary eclipse for circular orbits, placing 2σ upper limits on |ecos ω| of 0.0053 and 0.0080, both of which are consistent with circular orbits. The dayside emission spectra of these planets are well-described by blackbodies with effective temperatures of 2158 ± 100 K (WASP-48b) and 2154 ± 90 K (HAT-P-23b), corresponding to moderate recirculation in the zero albedo case. Our measured eclipse depths are also consistent with one-dimensional radiative transfer models featuring varying degrees of recirculation and weak thermal inversions or no inversions at all. We discuss how the absence of strong temperature inversions on these planets may be related to the activity levels and metallicities of their host stars.

  14. Clinical study on HAT and SEDAN score scales and related risk factors for predicting hemorrhagic transformation following thrombolysis in acute ischemic stroke

    Directory of Open Access Journals (Sweden)

    Heng WEI

    2015-03-01

    Full Text Available Objective To investigate the value of HAT and SEDAN score scales in predicting hemorrhagic transformation (HT following the recombinant tissue-type plasminogen activator (rt-PA intravenous thrombolysis in acute ischemic stroke patients and risk factors affecting HT.  Methods A total of 143 patients with acute ischemic stroke underwent rt-PA intravenous thrombolysis within 4.50 h of onset and their clinical data were collected. According to head CT after thrombolysis, patients were divided into HT group (18 cases and non-HT group (125 cases. Single factor analysis was used to assess differences in HAT and SEDAN score scales and related risk factors of ischemic stroke in 2 groups, and further Logistic regression analysis was used to investigate independent predictors of HT. Receiver operating characteristic (ROC curve was used to evaluate the sensitivity and specificity of HAT and SEDAN score scales in predicting HT.  Results Univariate Logistic regression analysis showed that history of atrial fibrillation (AF, admission systolic blood pressure (SBP, admission blood glucose level, early low density of head CT, thrombolytic time window, National Institute of Health Stroke Scale (NIHSS, HAT and SEDAN scores were all risk factors for HT after thrombolysis (P < 0.05, for all. Multivariate Logistic regression analysis showed that history of AF (OR = 1.677, 95% CI: 1.332-2.111; P = 0.000, admission SBP (OR = 1.102, 95% CI: 1.009-1.204; P = 0.031, admission blood glucose level (OR = 1.870, 95% CI: 1.119-3.125; P = 0.017, thrombolysis time window (OR = 1.030, 95%CI: 1.009-1.052; P = 0.005, NIHSS score (OR = 1.574, 95%CI: 1.186-2.090; P = 0.002, HAT score (OR = 2.515, 95%CI: 1.273-4.970;P = 0.008 and SEDAN score (OR = 2.413, 95%CI: 1.123-5.185; P = 0.024 were risk factors for HT after thrombolysis. ROC curve analysis showed that HAT score could predict HT with 94.40% sensitivity and 41.60% specificity, and area under curve (AUC was 0.70. SEDAN

  15. Classification of Ultra-High Resolution Orthophotos Combined with DSM Using a Dual Morphological Top Hat Profile

    Directory of Open Access Journals (Sweden)

    Qian Zhang

    2015-12-01

    Full Text Available New aerial sensors and platforms (e.g., unmanned aerial vehicles (UAVs are capable of providing ultra-high resolution remote sensing data (less than a 30-cm ground sampling distance (GSD. This type of data is an important source for interpreting sub-building level objects; however, it has not yet been explored. The large-scale differences of urban objects, the high spectral variability and the large perspective effect bring difficulties to the design of descriptive features. Therefore, features representing the spatial information of the objects are essential for dealing with the spectral ambiguity. In this paper, we proposed a dual morphology top-hat profile (DMTHP using both morphology reconstruction and erosion with different granularities. Due to the high dimensional feature space, we have proposed an adaptive scale selection procedure to reduce the feature dimension according to the training samples. The DMTHP is extracted from both images and Digital Surface Models (DSM to obtain complimentary information. The random forest classifier is used to classify the features hierarchically. Quantitative experimental results on aerial images with 9-cm and UAV images with 5-cm GSD are performed. Under our experiments, improvements of 10% and 2% in overall accuracy are obtained in comparison with the well-known differential morphological profile (DMP feature, and superior performance is observed over other tested features. Large format data with 20,000 × 20,000 pixels are used to perform a qualitative experiment using the proposed method, which shows its promising potential. The experiments also demonstrate that the DSM information has greatly enhanced the classification accuracy. In the best case in our experiment, it gives rise to a classification accuracy from 63.93% (spectral information only to 94.48% (the proposed method.

  16. Characterization and biological treatment of colored textile wastewaters from the typical Tunisian hat Chechia dyeing using newly isolated Aspergillus niger

    Directory of Open Access Journals (Sweden)

    Hajer Barouni

    2016-09-01

    Full Text Available This study aimed to characterize and investigate, for the first time, the treatment of real colored wastewaters from the artisanal dyeing of the typical Tunisian hat Chechia, using a newly isolated fungal strain. This textile effluent was a mixture called Mix of colored wastewaters from the three main types of Chechia. The major pollutant of the Mix was the toxic Azo dye Amaranth Acid or Acid Red 27. The fungal strain that made the cleanup was discovered in a Chechia dyeing wastewater’s container and identified by ITS rDNA gene sequencing. This isolated Aspergillus niger showed interesting performances on the demonstration of Chechia wastewater’s biodegradation in batch cultures. In order to understand the effect of agitation, Mix dilution and inoculum size on decolourisation and pollution removal, a full factorial experimental design 23 was set up. At the optimal conditions which were 20% inoculum size, 25% Chechia Mix dilution and an agitation of 100 rpm, Aspergillus niger was able to remove color as high as 70.18±2.84% at an initial dye concentration of 1346.6±0.01 mg/L, and to reduce COD to 74.17±14.52% at an initial COD of 4157±422 mg/L. FT-IR spectra analysis confirmed the decolourisation by biodegradation and transformation of the dyes. The treatment by the isolated Aspergillus niger could be successfully applied as a sustainable method to solve one of handicraft dyeing plants environmental management issues.

  17. Household wireless electroencephalogram hat

    Science.gov (United States)

    Szu, Harold; Hsu, Charles; Moon, Gyu; Yamakawa, Takeshi; Tran, Binh

    2012-06-01

    We applied Compressive Sensing to design an affordable, convenient Brain Machine Interface (BMI) measuring the high spatial density, and real-time process of Electroencephalogram (EEG) brainwaves by a Smartphone. It is useful for therapeutic and mental health monitoring, learning disability biofeedback, handicap interfaces, and war gaming. Its spec is adequate for a biomedical laboratory, without the cables hanging over the head and tethered to a fixed computer terminal. Our improved the intrinsic signal to noise ratio (SNR) by using the non-uniform placement of the measuring electrodes to create the proximity of measurement to the source effect. We computing a spatiotemporal average the larger magnitude of EEG data centers in 0.3 second taking on tethered laboratory data, using fuzzy logic, and computing the inside brainwave sources, by Independent Component Analysis (ICA). Consequently, we can overlay them together by non-uniform electrode distribution enhancing the signal noise ratio and therefore the degree of sparseness by threshold. We overcame the conflicting requirements between a high spatial electrode density and precise temporal resolution (beyond Event Related Potential (ERP) P300 brainwave at 0.3 sec), and Smartphone wireless bottleneck of spatiotemporal throughput rate. Our main contribution in this paper is the quality and the speed of iterative compressed image recovery algorithm based on a Block Sparse Code (Baranuick et al, IEEE/IT 2008). As a result, we achieved real-time wireless dynamic measurement of EEG brainwaves, matching well with traditionally tethered high density EEG.

  18. HAT-P-12b: A LOW-DENSITY SUB-SATURN MASS PLANET TRANSITING A METAL-POOR K DWARF

    International Nuclear Information System (INIS)

    Hartman, J. D.; Bakos, G. A.; Torres, G.; Noyes, R. W.; Pal, A.; Latham, D. W.; Sipocz, B.; Esquerdo, G. A.; Sasselov, D. D.; Kovacs, Gabor; Stefanik, R. P.; Fernandez, J. M.; Kovacs, Geza; Fischer, D. A.; Johnson, J. A.; Marcy, G. W.; Howard, A. W.; Butler, R. P.; Lazar, J.; Papp, I.

    2009-01-01

    We report on the discovery of HAT-P-12b, a transiting extrasolar planet orbiting the moderately bright V ∼ 12.8 K4 dwarf GSC 03033 - 00706, with a period P = 3.2130598 ± 0.0000021 d, transit epoch T c = 2454419.19556 ± 0.00020 (BJD), and transit duration 0.0974 ± 0.0006 d. The host star has a mass of 0.73 ± 0.02 M sun , radius of 0.70 +0.02 -0.01 R sun , effective temperature 4650 ± 60 K, and metallicity [Fe/H] = -0.29 ± 0.05. We find a slight correlation between the observed spectral line bisector spans and the radial velocity, so we consider, and rule out, various blend configurations including a blend with a background eclipsing binary, and hierarchical triple systems where the eclipsing body is a star or a planet. We conclude that a model consisting of a single star with a transiting planet best fits the observations, and show that a likely explanation for the apparent correlation is contamination from scattered moonlight. Based on this model, the planetary companion has a mass of 0.211 ± 0.012 M J and radius of 0.959 +0.029 -0.021 R J yielding a mean density of 0.295 ± 0.025 g cm -3 . Comparing these observations with recent theoretical models, we find that HAT-P-12b is consistent with a ∼1-4.5 Gyr, mildly irradiated, H/He-dominated planet with a core mass M C ∼ + . HAT-P-12b is thus the least massive H/He-dominated gas giant planet found to date. This record was previously held by Saturn.

  19. Transiting Exoplanet Monitoring Project (TEMP). IV. Refined System Parameters, Transit Timing Variations, and Orbital Stability of the Transiting Planetary System HAT-P-25

    Science.gov (United States)

    Wang, Xian-Yu; Wang, Songhu; Hinse, Tobias C.; Li, Kai; Wang, Yong-Hao; Laughlin, Gregory; Liu, Hui-Gen; Zhang, Hui; Wu, Zhen-Yu; Zhou, Xu; Zhou, Ji-Lin; Hu, Shao-Ming; Wu, Dong-Hong; Peng, Xi-Yan; Chen, Yuan-Yuan

    2018-06-01

    We present eight new light curves of the transiting extra-solar planet HAT-P-25b obtained from 2013 to 2016 with three telescopes at two observatories. We use the new light curves, along with recent literature material, to estimate the physical and orbital parameters of the transiting planet. Specifically, we determine the mid-transit times (T C ) and update the linear ephemeris, T C[0] = 2456418.80996 ± 0.00025 [BJDTDB] and P = 3.65281572 ± 0.00000095 days. We carry out a search for transit timing variations (TTVs), and find no significant TTV signal at the ΔT = 80 s-level, placing a limit on the possible strength of planet–planet interactions (TTVG). In the course of our analysis, we calculate the upper mass-limits of the potential nearby perturbers. Near the 1:2, 2:1, and 3:1 resonances with HAT-P-25b, perturbers with masses greater than 0.5, 0.3, and 0.5 M ⊕ respectively, can be excluded. Furthermore, based on the analysis of TTVs caused by light travel time effect (LTTE) we also eliminate the possibility that a long-period perturber exists with M p > 3000 MJ within a = 11.2 au of the parent star.

  20. HAT-P-49b: a 1.7 M {sub J} planet transiting a bright 1.5 M {sub ☉} F-star

    Energy Technology Data Exchange (ETDEWEB)

    Bieryla, A.; Latham, D. W.; Buchhave, L. A.; Béky, B.; Falco, E.; Torres, G.; Noyes, R. W.; Berlind, P.; Calkins, M. C.; Esquerdo, G. A. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Hartman, J. D.; Bakos, G. Á.; Bhatti, W.; Csubry, Z.; Penev, K.; De Val-Borro, M. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Kovács, G. [Konkoly Observatory, Budapest 1121 (Hungary); Boisse, I. [Centro de Astrofísica, Universidade do Porto, Rua das Estrelas, 4150-762 Porto (Portugal); Lázár, J.; Papp, I., E-mail: abieryla@cfa.harvard.edu, E-mail: gbakos@astro.princeton.edu [Hungarian Astronomical Association (HAA), Budapest 1461 (Hungary); and others

    2014-04-01

    We report the discovery of the transiting extrasolar planet HAT-P-49b. The planet transits the bright (V = 10.3) slightly evolved F-star HD 340099 with a mass of 1.54 M {sub ☉} and a radius of 1.83 R {sub ☉}. HAT-P-49b is orbiting one of the 25 brightest stars to host a transiting planet which makes this a favorable candidate for detailed follow-up. This system is an especially strong target for Rossiter-McLaughlin follow-up due to the host star's fast rotation, 16 km s{sup –1}. The planetary companion has a period of 2.6915 days, mass of 1.73 M {sub J}, and radius of 1.41 R {sub J}. The planetary characteristics are consistent with that of a classical hot Jupiter but we note that this is the fourth most massive star to host a transiting planet with both M{sub p} and R{sub p} well determined.

  1. Path representation of su-hat (2){sub k} states II: Operator construction of the fermionic character and spin-1/2 -RSOS factorization

    Energy Technology Data Exchange (ETDEWEB)

    Lamy-Poirier, Joel, E-mail: jlamypoirier@perimeterinstitute.c [Departement de Physique, de Genie Physique et d' Optique, Universite Laval, Quebec, Canada, G1V 0A6 (Canada); Mathieu, Pierre, E-mail: pmathieu@phy.ulaval.c [Departement de Physique, de Genie Physique et d' Optique, Universite Laval, Quebec, Canada, G1V 0A6 (Canada)

    2011-06-01

    This is the second of two articles (independent of each other) devoted to the analysis of the path description of the states in su-hat (2){sub k} WZW models. Here we present a constructive derivation of the fermionic character at level k based on these paths. The starting point is the expression of a path in terms of a sequence of nonlocal (formal) operators acting on the vacuum ground-state path. Within this framework, the key step is the construction of the level-k operator sequences out of those at level-1 by the action of a new type of operators. These actions of operators on operators turn out to have a path interpretation: these paths are precisely the finitized RSOS paths related to the unitary minimal models M(k+1,k+2). We thus unravel - at the level of the path representation of the states - a direct factorization into a k=1 spinon part times a RSOS factor. It is also pointed out that since there are two fermionic forms describing these finite RSOS paths, the resulting fermionic su-hat (2){sub k} characters arise in two versions. Finally, the relation between the present construction and the Nagoya spectral decomposition of the path space is sketched.

  2. KEPLER'S OPTICAL SECONDARY ECLIPSE OF HAT-P-7b AND PROBABLE DETECTION OF PLANET-INDUCED STELLAR GRAVITY DARKENING

    Energy Technology Data Exchange (ETDEWEB)

    Morris, Brett M.; Deming, Drake [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Mandell, Avi M. [Goddard Center for Astrobiology, NASA' s Goddard Space Flight Center, Greenbelt, MD 20771 (United States)

    2013-02-20

    We present observations spanning 355 orbital phases of HAT-P-7 observed by Kepler from 2009 May to 2011 March (Q1-9). We find a shallower secondary eclipse depth than initially announced, consistent with a low optical albedo and detection of nearly exclusively thermal emission, without a reflected light component. We find an approximately 10 ppm perturbation to the average transit light curve near phase -0.02 that we attribute to a temperature decrease on the surface of the star, phased to the orbit of the planet. This cooler spot is consistent with planet-induced gravity darkening, slightly lagging the sub-planet position due to the finite response time of the stellar atmosphere. The brightness temperature of HAT-P-7b in the Kepler bandpass is T{sub B} = 2733 {+-} 21 K and the amplitude of the deviation in stellar surface temperature due to gravity darkening is approximately -0.18 K. The detection of the spot is not statistically unequivocal due its small amplitude, though additional Kepler observations should be able to verify the astrophysical nature of the anomaly.

  3. Ein Nachkömmling Tristans : Warum hat Theodor Storm in seiner Novelle „Späte Rosen" Gottfried von Straßburgs „Tristan und Isolde" erwähnt?

    OpenAIRE

    田淵, 昌太

    2010-01-01

    Man hat bisher Theodor Storms Novelle „Späte Rosen" für ein Werk gehalten, das ein friedliches Familienleben beziehungweise das tägliche Zusammenleben eines Ehepaars schildert. Zum Beispiel hat Beate Charlotte Göhler in ihrer umfangreichen Storm-Biografie geschrieben, dass Theodor Storm mit diesem Werk seiner Frau Constanze eine Liebeserklärung machte („Ein Leben für die Graue Stadt" S.198). Wenn man diese Novelle nur oberflächlich liest, ist es eine mögliche Folge, dass man „Späte Rosen"...

  4. The HAT TRICK programme for improving physical activity, healthy eating and connectedness among overweight, inactive men: study protocol of a pragmatic feasibility trial.

    Science.gov (United States)

    Caperchione, Cristina M; Bottorff, Joan L; Oliffe, John L; Johnson, Steven T; Hunt, Kate; Sharp, Paul; Fitzpatrick, Kayla M; Price, Ryley; Goldenberg, S Larry

    2017-09-06

    Physical activity, healthy eating and maintaining a healthy weight are associated with reduced risk of cardiovascular disease, type 2 diabetes and cancer and with improved mental health. Despite these benefits, many men do not meet recommended physical activity guidelines and have poor eating behaviours. Many health promotion programmes hold little appeal to men and consequently fail to influence men's health practices. HAT TRICK was designed as a 12-week face-to-face, gender-sensitised intervention for overweight and inactive men focusing on physical activity, healthy eating and social connectedness and was delivered in collaboration with a major junior Canadian ice hockey team (age range 16-20 years). The programme was implemented and evaluated to assess its feasibility. This article describes the intervention design and study protocol of HAT TRICK. HAT TRICK participants (n=60) were men age 35 years, residing in the Okanagan Region of British Columbia, who accumulate 150 min of moderate to vigorous physical activity a week, with a body mass index of >25 kg/m 2 and a pant waist size of >38'. Each 90 min weekly session included targeted health education and theory-guided behavioural change techniques, as well as a progressive (ie, an increase in duration and intensity) group physical activity component. Outcome measures were collected at baseline, 12 weeks and 9 months and included the following: objectively measured anthropometrics, blood pressure, heart rate, physical activity and sedentary behaviour, as well as self-reported physical activity, sedentary behaviour, diet, smoking, alcohol consumption, sleep habits, risk of depression, health-related quality of life and social connectedness. Programme feasibility data (eg, recruitment, satisfaction, adherence, content delivery) were assessed at 12 weeks via interviews and self-report. Ethical approval was obtained from the University of British Columbia Okanagan Behavioural Research Ethics Board (reference no H

  5. Estimation of gas-particle partitioning coefficients (Kp) of carcinogenic polycyclic aromatic hydrocarbons in carbonaceous aerosols collected at Chiang-Mai, Bangkok and Hat-Yai, Thailand.

    Science.gov (United States)

    Pongpiachan, Siwatt; Ho, Kin Fai; Cao, Junji

    2013-01-01

    To assess environmental contamination with carcinogens, carbonaceous compounds, water-soluble ionic species and trace gaseous species were identified and quantified every three hours for three days at three different atmospheric layers at the heart of Chiang-Mai, Bangkok and Hat-Yai from December 2006 to February 2007. A DRI Model 2001 Thermal/Optical Carbon Analyzer with the IMPROVE thermal/optical reflectance (TOR) protocol was used to quantify the organic carbon (OC) and elemental carbon (EC) contents in PM10. Diurnal and vertical variability was also carefully investigated. In general, OC and EC mass concentration showed the highest values at the monitoring period of 21.00-00.00 as consequences of human activities at night bazaar coupled with reduction of mixing layer, decreased wind speed and termination of photolysis at nighttime. Morning peaks of carbonaceous compounds were observed during the sampling period of 06:00-09:00, emphasizing the main contribution of traffic emission in the three cities. The estimation of incremental lifetime particulate matter exposure (ILPE) raises concern of high risk of carbonaceous accumulation over workers and residents living close to the observatory sites. The average values of incremental lifetime particulate matter exposure (ILPE) of total carbon at Baiyoke Suit Hotel and Baiyoke Sky Hotel are approximately ten times higher than those air samples collected at Prince of Songkla University Hat-Yai campus corpse incinerator and fish-can manufacturing factory but only slightly higher than those of rice straw burning in Songkla province. This indicates a high risk of developing lung cancer and other respiratory diseases across workers and residents living in high buildings located in Pratunam area. Using knowledge of carbonaceous fractions in PM10, one can estimate the gas-particle partitioning of polycyclic aromatic hydrocarbons (PAHs). Dachs-Eisenreich model highlights the crucial role of adsorption in gas

  6. "Das Konkrete ist das Abstrakte, an das man sich schließlich gewöhnt hat." (Laurent Schwartz) Über den Ablauf des mathematischen Verstehens

    Science.gov (United States)

    Lowsky, Martin

    Die im Titel genannte Aussage findet sich in den Lebenserinnerungen von Laurent Schwartz (1915-2002), einem der fruchtbarsten Mathematiker, Mitglied der Gruppe Bourbaki. Im Original lautet die Aussage: "un objet concret est un objet abstrait auquel on a fini par s'habituer." Schwartz erläutert sie am Beispiel des Integrals über {e^{-1/2{x^2}}} , das den Wert Wurzel aus 2π hat und in dem sich also die Zahlen e und π verknüpfen. Was Schwartz aber vor allem ausdrücken will, ist dies: Das mathematische Verständnisd geht langsam vor sich und es bedarf der Anstrengung. "Es ist eine Frage der Zeit und der Energie", sagt Schwartz, und gerade dies mache es so schwer, die höhere Mathematik unter das Volk zu bringen. Das Lernen und Lehren von Mathematik laufe eben mühevoll und langsam ab.

  7. Co-located hAT transposable element and 5S rDNA in an interstitial telomeric sequence suggest the formation of Robertsonian fusion in armored catfish.

    Science.gov (United States)

    Glugoski, Larissa; Giuliano-Caetano, Lucia; Moreira-Filho, Orlando; Vicari, Marcelo R; Nogaroto, Viviane

    2018-04-15

    Co-located 5S rDNA genes and interstitial telomeric sites (ITS) revealed the involvement of multiple 5S rDNA clusters in chromosome rearrangements of Loricariidae. Interstitial (TTAGGG)n vestiges, in addition to telomeric sites, can coincide with locations of chromosomal rearrangements, and they are considered to be hotspots for chromosome breaks. This study aimed the molecular characterization of 5S rDNA in two Rineloricaria latirostris populations and examination of roles of 5S rDNA in breakpoint sites and its in situ localization. Rineloricaria latirostris from Brazil's Das Pedras river (2n = 46 chromosomes) presented five pairs identified using a 5S rDNA probe, in addition to a pair bearing a co-located ITS/5S rDNA. Rineloricaria latirostris from the Piumhi river (2n = 48 chromosomes) revealed two pairs containing 5S rDNA, without ITS. A 702-bp amplified sequence, using 5S rDNA primers, revealed an insertion of the hAT transposable element (TE), referred to as a degenerate 5S rDNA. Double-FISH (fluorescence in situ hybridization) demonstrated co-localization of 5S rDNA/degenerate 5S rDNA, 5S rDNA/hAT and ITS/5S rDNA from the Das Pedras river population. Piumhi river isolates possessed only 5S rDNA sites. We suggest that the degenerate 5S rDNA was generated by unequal crossing over, which was driven by invasion of hAT, establishing a breakpoint region susceptible to chromosome breakage, non-homologous recombination and Robertsonian (Rb) fusion. Furthermore, the presence of clusters of 5S rDNA at fusion points in other armored catfish species suggests its re-use and that these regions represent hotspots for evolutionary rearrangements within Loricariidae genomes. Copyright © 2018 Elsevier B.V. All rights reserved.

  8. Hypoglycaemia in patients with type 1 and type 2 diabetes mellitus on insulin therapy. Results of the global HAT study in Argentina

    Directory of Open Access Journals (Sweden)

    José E. Costa Gil

    2017-12-01

    Full Text Available We describe the results of the HAT study in 433 Argentinean patients with type 1 diabetes (T1D and 823 with type 2 diabetes (T2D. HAT was an international non-interventional study assessing severe and non-severe hypoglycaemia in patients with T1D and T2D under insulin treatment through a two-part self-assessment questionnaire (retrospective and prospective. The annual incidence of at least one hypoglycaemic episode was 46 episode/patient/year in T1D and 14.2 in T2D (retrospective, 96.5 and 24.6 episode/patient/year in T1D and T2D, respectively (prospective. Hypoglycaemia affected quality of life (on a scale of 0-10 for fear of hypoglycaemia: 60% in T1D and 37.6% in T2D scored 5 to 10, daily life, occupational or academic performance (2.1% with T1D and 3.2% with T2D did not attend to their work after hypoglycaemia, and induced an increased use of health resources (T1D: 66.1% increased glucose monitoring, 60.5% food intake, 51% consultations, 3.5% hospital admissions; 60.5% reduced insulin and 20.9% exercises; T2D increased 46.2% glucose monitoring, 43.8% consultations, 38.6% food intake, 24.1% reduced and 13.9% skipped the insulin dose and 14.3% suspended exercises. Greater numbers of episodes were recorded in the prospective period. An instrument to assess hypoglycaemia in clinical practice and strategies to reduce their risk are required. It is also important to ask about the episodes and reinforce the education of patients and close relatives on hypoglycaemia prevention and treatment

  9. Tectonic geomorphology and volcano-tectonic interaction in the eastern boundary of the Southern Cascades (Hat Creek Graben region, California, USA

    Directory of Open Access Journals (Sweden)

    Engielle Mae Raot-raot Paguican

    2016-07-01

    Full Text Available The eastern boundary of the Southern Cascades (Hat Creek Graben region, California, USA, is an extensively faulted volcanic corridor between the Cascade Range and Modoc Plateau. The east-west extending region is in the transition zone between the convergence and subduction of the Gorda Plate underneath the North American Plate; north-south shortening within the Klamath Mountain region; and transcurrent movement in the Walker Lane. We describe the geomorphological and tectonic features, their alignment and distribution, in order to understand the tectonic geomorphology and volcano-tectonic relationships. One outcome of the work is a more refined morpho-structural description that will affect future hazard assessment in the area.A database of volcanic centers and structures was created from interpretations of topographic models generated from satellite images. Volcanic centers in the region were classified by morphological type into cones, sub-cones, shields and massifs. A second classification by height separated the bigger and smaller edifices and revealed an evolutionary trend. Poisson Nearest Neighbor analysis shows that bigger volcanoes are spatially dispersed while smaller ones are clustered. Using volcano centroid locations, about 90 lineaments consisting of at least three centers within 6km of one another were found, revealing that preferential north-northwest directed pathways control the transport of magma from the source to the surface, consistent with the strikes of the major fault systems. Most of the volcano crater openings are perpendicular to the maximum horizontal stress, expected for extensional environments with dominant normal regional faults. These results imply that the extension of the Hat Creek Graben region and impingement of the Walker Lane is accommodated mostly by extensional faults and partly by the intrusions that formed the volcanoes. Early in the history of a volcano or volcano cluster, melt produced at depth in the

  10. HAT-TR-318-007: A Double-lined M Dwarf Binary with Total Secondary Eclipses Discovered by HATNet and Observed by K2

    Science.gov (United States)

    Hartman, J. D.; Quinn, S. N.; Bakos, G. Á.; Torres, G.; Kovács, G.; Latham, D. W.; Noyes, R. W.; Shporer, A.; Fulton, B. J.; Esquerdo, G. A.; Everett, M. E.; Penev, K.; Bhatti, W.; Csubry, Z.

    2018-03-01

    We report the discovery by the HATNet survey of HAT-TR-318-007, a P=3.34395390+/- 0.00000020 day period detached double-lined M dwarf binary with total secondary eclipses. We combine radial velocity (RV) measurements from TRES/FLWO 1.5 m and time-series photometry from HATNet, FLWO 1.2 m, BOS 0.8 m, and NASA K2 Campaign 5, to determine the masses and radii of the component stars: MA=0.448+/-0.011 M⊙N, MB=0.2721-0.0042+0.0041 M⊙N, RA=0.4548-0.0036+0.0035 R⊙N, and RB=0.2913-0.0024+0.0023 R⊙N. We obtained a FIRE/Magellan near-infrared spectrum of the primary star during a total secondary eclipse, and we use this to obtain disentangled spectra of both components. We determine spectral types of STA=M 3.71+/- 0.69 and STB=M 5.01+/- 0.73 and effective temperatures of Teff, A= 3190+/-110 K and Teff, B=3100+/- 110 K for the primary and secondary star, respectively. We also measure a metallicity of [Fe/H] = +0.298+/- 0.080 for the system. We find that the system has a small, but significant, nonzero eccentricity of 0.0136+/- 0.0026. The K2 light curve shows a coherent variation at a period of 3.41315-0.00032+0.00030 days, which is slightly longer than the orbital period, and which we demonstrate comes from the primary star. We interpret this as the rotation period of the primary. We perform a quantitative comparison between the Dartmouth stellar evolution models and the seven systems, including HAT-TR-318-007, that contain M dwarfs with 0.2 M⊙N< M< 0.5 M⊙N, have metallicity measurements, and have masses and radii determined to better than 5% precision. Discrepancies between the predicted and observed masses and radii are found for three of the systems.

  11. Evolutionary origin of Rosaceae-specific active non-autonomous hAT elements and their contribution to gene regulation and genomic structural variation.

    Science.gov (United States)

    Wang, Lu; Peng, Qian; Zhao, Jianbo; Ren, Fei; Zhou, Hui; Wang, Wei; Liao, Liao; Owiti, Albert; Jiang, Quan; Han, Yuepeng

    2016-05-01

    Transposable elements account for approximately 30 % of the Prunus genome; however, their evolutionary origin and functionality remain largely unclear. In this study, we identified a hAT transposon family, termed Moshan, in Prunus. The Moshan elements consist of three types, aMoshan, tMoshan, and mMoshan. The aMoshan and tMoshan types contain intact or truncated transposase genes, respectively, while the mMoshan type is miniature inverted-repeat transposable element (MITE). The Moshan transposons are unique to Rosaceae, and the copy numbers of different Moshan types are significantly correlated. Sequence homology analysis reveals that the mMoshan MITEs are direct deletion derivatives of the tMoshan progenitors, and one kind of mMoshan containing a MuDR-derived fragment were amplified predominately in the peach genome. The mMoshan sequences contain cis-regulatory elements that can enhance gene expression up to 100-fold. The mMoshan MITEs can serve as potential sources of micro and long noncoding RNAs. Whole-genome re-sequencing analysis indicates that mMoshan elements are highly active, and an insertion into S-haplotype-specific F-box gene was reported to cause the breakdown of self-incompatibility in sour cherry. Taken together, all these results suggest that the mMoshan elements play important roles in regulating gene expression and driving genomic structural variation in Prunus.

  12. Investigations of solution-processed charge generation unit with low concentration of small molecule doped in p-type/HAT-CN{sub 6} for tandem OLED

    Energy Technology Data Exchange (ETDEWEB)

    Talik, N.A., E-mail: azrina_talik@hotmail.com [Low Dimensional Material Research Centre (LDMRC), Physics Dept., Faculty of Science, University of Malaya, 50603 Kuala Lumpur (Malaysia); Yeoh, K.H. [Low Dimensional Material Research Centre (LDMRC), Physics Dept., Faculty of Science, University of Malaya, 50603 Kuala Lumpur (Malaysia); Centre for Photonics and Advanced Materials Research (CPR), Lee Kong Chian Faculty of Engineering and Science, University Tunku Abdul Rahman, 43000 Kajang, Selangor (Malaysia); Ng, C.Y.B. [Low Dimensional Material Research Centre (LDMRC), Physics Dept., Faculty of Science, University of Malaya, 50603 Kuala Lumpur (Malaysia); Tan, C.Y. [Centre of Advanced Manufacturing & Material Processing (AMMP), Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur (Malaysia); Yap, B.K., E-mail: kbyap@uniten.edu.my [Centre of Microelectronic and Nano Engineering (CeMNE), College of Engineering, Universiti Tenaga Nasional, 43000 Kajang, Selangor (Malaysia)

    2016-01-15

    We investigated the charge generation and injection mechanism in solution processed charge generation unit (CGU) used in our high performance tandem organic light emitting diode (OLED) via capacitance–voltage (C–V) and current density–voltage (J–V) measurements. By doping 2 wt% of small molecule 1,1-bis-(4-bis(4-tolyl)-aminophenyl) cyclohexene (TAPC) into Poly (N-vinylcarbazole) (PVK) as p-type layer of the CGU, we obtained more than two folds improvement in the tandem device efficiency compared to single device. The performance improvement of the TAPC doped CGU could be attributed to low built-in potential, large vacuum level shift as well as high charge density for efficient charge generation. - Highlights: • Charge-generation and injection mechanism in CGU for tandem OLED is investigated. • Small molecule, TAPC doped in p-type/HAT-CN{sub 6} has been used for tandem OLED. • The improvement attributes to the lower V{sub bi} and larger ΔV{sub L} in doped layer. • Narrower W and high carrier density also contribute to efficiency improvement.

  13. Investigations of solution-processed charge generation unit with low concentration of small molecule doped in p-type/HAT-CN6 for tandem OLED

    International Nuclear Information System (INIS)

    Talik, N.A.; Yeoh, K.H.; Ng, C.Y.B.; Tan, C.Y.; Yap, B.K.

    2016-01-01

    We investigated the charge generation and injection mechanism in solution processed charge generation unit (CGU) used in our high performance tandem organic light emitting diode (OLED) via capacitance–voltage (C–V) and current density–voltage (J–V) measurements. By doping 2 wt% of small molecule 1,1-bis-(4-bis(4-tolyl)-aminophenyl) cyclohexene (TAPC) into Poly (N-vinylcarbazole) (PVK) as p-type layer of the CGU, we obtained more than two folds improvement in the tandem device efficiency compared to single device. The performance improvement of the TAPC doped CGU could be attributed to low built-in potential, large vacuum level shift as well as high charge density for efficient charge generation. - Highlights: • Charge-generation and injection mechanism in CGU for tandem OLED is investigated. • Small molecule, TAPC doped in p-type/HAT-CN 6 has been used for tandem OLED. • The improvement attributes to the lower V bi and larger ΔV L in doped layer. • Narrower W and high carrier density also contribute to efficiency improvement.

  14. Comparison of the effects of 665 nm low level diode Laser Hat versus and a combination of 665 nm and 808nm low level diode Laser Scanner of hair growth in androgenic alopecia.

    Science.gov (United States)

    Barikbin, Behrooz; Khodamrdi, Zeinab; Kholoosi, Leila; Akhgri, Mohammad Reza; Haj Abbasi, Majid; Hajabbasi, Mojgan; Razzaghi, Zahra; Akbarpour, Samaneh

    2017-05-17

    This study aimed to evaluate the effectiveness of a combined set of low level diode laser scanner (665 nm and 808nm) on hair growth, and assessment of safety and effectiveness of a new laser scanner on hair growth treatment procedure in androgenic alopecia. 90 patients (18 to 70 years) with androgenic alopecia were randomized into three groups. The first group (n=30) received 655 nm red light using laser hat, the second group (n=30) received 655 nm red laser plus 808 nm infrared laser using a laser scanner of hair growth device (with the patent number: 77733) and the third group (n=30) received no laser as the control group. Patients in laser scanner group had better results and showed a higher increase in terminal hair density compared with laser hat group (mean of 9.61 versus 9.16 per cm 2 ). We found significant decrease in terminal hair density from baseline in control group (mean -1.8 per cm 2 , plaser scanner of the hair growth group compared with laser hat and the control group. The study showed that treatment with new laser devise had a promising result without any observable adverse effects.

  15. Histone acetyltransferase (HAT) activity of p300 modulates human T lymphotropic virus type 1 p30II-mediated repression of LTR transcriptional activity

    International Nuclear Information System (INIS)

    Michael, Bindhu; Nair, Amrithraj M.; Datta, Antara; Hiraragi, Hajime; Ratner, Lee; Lairmore, Michael D.

    2006-01-01

    Human T-lymphotropic virus type-1 (HTLV-1) is a deltaretrovirus that causes adult T cell leukemia/lymphoma, and is implicated in a variety of lymphocyte-mediated inflammatory disorders. HTLV-1 provirus has regulatory and accessory genes in four pX open reading frames. HTLV-1 pX ORF-II encodes two proteins, p13 II and p30 II , which are incompletely defined in virus replication or pathogenesis. We have demonstrated that pX ORF-II mutations block virus replication in vivo and that ORF-II encoded p30 II , a nuclear-localizing protein that binds with CREB-binding protein (CBP)/p300, represses CREB and Tax responsive element (TRE)-mediated transcription. Herein, we have identified p30 II motifs important for p300 binding and in regulating TRE-mediated transcription in the absence and presence of HTLV-1 provirus. Within amino acids 100-179 of p30 II , a region important for repression of LTR-mediated transcription, we identified a single lysine residue at amino acid 106 (K3) that significantly modulates the ability of p30 II to repress TRE-mediated transcription. Exogenous p300, in a dose-responsive manner, reverses p30 II -dependent repression of TRE-mediated transcription, in the absence or presence of the provirus, In contrast to wild type p300, p300 HAT mutants (defective in histone acetyltransferase activity) only partially rescued p30 II -mediated LTR repression. Deacetylation by histone deacetylase-1 (HDAC-1) enhanced p30 II -mediated LTR repression, while inhibition of deacetylation by trichostatin A decreases p30 II -mediated LTR repression. Collectively, our data indicate that HTLV-1 p30 II modulates viral gene expression in a cooperative manner with p300-mediated acetylation

  16. Origin and potential geothermal significance of China Hat and other late Pleistocene topaz rhyolite lava domes of the Blackfoot Volcanic Field, SE Idaho

    Science.gov (United States)

    McCurry, M. O.; Pearson, D. M.; Welhan, J. A.; Kobs-Nawotniak, S. E.; Fisher, M. A.

    2014-12-01

    The Snake River Plain and neighboring regions are well known for their high heat flow and robust Neogene-Quaternary tectonic and magmatic activity. Interestingly, however, there are comparatively few surficial manifestations of geothermal activity. This study is part of a renewed examination of this region as a possible hidden or blind geothermal resource. We present a testable, integrated volcanological, petrogenetic, tectonic and hydrothermal conceptual model for 57 ka China Hat and cogenetic topaz rhyolite lava domes of the Blackfoot Volcanic Field. This field is well suited for analysis as a blind resource because of its distinctive combination of (1) young bimodal volcanism, petrogenetic evidence of shallow magma storage and evolution, presence of coeval extension, voluminous travertine deposits, and C- and He-isotopic evidence of active magma degassing; (2) a paucity of hot springs or other obvious indicators of a geothermal resource in the immediate vicinity of the lava domes; and (3) proximity to a region of high crustal heat flow, high-T geothermal fluids at 2.5-5 km depth and micro-seismicity characterized by its swarming nature. Eruptions of both basalt and rhyolite commonly evolve from minor phreatomagmatic to effusive. In our model, transport of both magmatic and possible deep crustal aqueous fluids may be controlled by preexisting crustal structures, including west-dipping thrust faults. Geochemical evolution of rhyolite magma is dominated by mid- to upper-crustal fractional crystallization (with pre-eruption storage and phenocryst formation at ~14 km). Approximately 1.2 km3 of topaz rhyolite have been erupted since 1.4 Ma, yielding an average eruption rate of 0.8 km3/m.y. Given reasonable assumptions of magma cumulate formation and eruption rates, and initial and final volatile concentrations, we infer average H2O and CO2 volatile fluxes from the rhyolite source region of ~2MT/year and 340 T/day, respectively. Lithium flux may be comparable to CO2.

  17. THE EVIL-MC MODEL FOR ELLIPSOIDAL VARIATIONS OF PLANET-HOSTING STARS AND APPLICATIONS TO THE HAT-P-7 SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, Brian K. [Carnegie Institution for Science, Washington, DC 20015 (United States); Lewis, Nikole K.; Showman, Adam P. [Lunar and Planetary Laboratory, University of Arizona, Kuiper Space Sciences Building, Tucson, AZ 85721 (United States); Barnes, Jason W. [Department of Physics, University of Idaho, Engineering-Physics Building, Moscow, ID 83844 (United States); Deming, L. Drake [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Fortney, Jonathan J., E-mail: bjackson@dtm.ciw.edu [Department of Astronomy and Astrophysics, UCO/Lick Observatory, University of California, Santa Cruz, CA 95064 (United States)

    2012-06-01

    We present a new model for Ellipsoidal Variations Induced by a Low-Mass Companion, the EVIL-MC model. We employ several approximations appropriate for planetary systems to substantially increase the computational efficiency of our model relative to more general ellipsoidal variation models and improve upon the accuracy of simpler models. This new approach gives us a unique ability to rapidly and accurately determine planetary system parameters. We use the EVIL-MC model to analyze Kepler Quarter 0-2 (Q0-2) observations of the HAT-P-7 system, an F-type star orbited by a {approx} Jupiter-mass companion. Our analysis corroborates previous estimates of the planet-star mass ratio q = (1.10 {+-} 0.06) Multiplication-Sign 10{sup -3}, and we have revised the planet's dayside brightness temperature to 2680{sup +10}{sub -20} K. We also find a large difference between the day- and nightside planetary flux, with little nightside emission. Preliminary dynamical+radiative modeling of the atmosphere indicates that this result is qualitatively consistent with high altitude absorption of stellar heating. Similar analyses of Kepler and CoRoT photometry of other planets using EVIL-MC will play a key role in providing constraints on the properties of many extrasolar systems, especially given the limited resources for follow-up and characterization of these systems. However, as we highlight, there are important degeneracies between the contributions from ellipsoidal variations and planetary emission and reflection. Consequently, for many of the hottest and brightest Kepler and CoRoT planets, accurate estimates of the planetary emission and reflection, diagnostic of atmospheric heat budgets, will require accurate modeling of the photometric contribution from the stellar ellipsoidal variation.

  18. All Hat and No Cattle

    Science.gov (United States)

    Holloway-Libell, Jessica; Amrein-Beardsley, Audrey; Collins, Clarin

    2012-01-01

    Recently, two of the authors (Amrein-Beardsley & Collins, 2012) studied the impact of Education Value-Added Assessment System (EVAAS), a value-added model used to judge Houston teachers' performance. They examined the cases of four teachers who were terminated in summer 2011, at least in part because of their subpar EVAAS scores. Talking to…

  19. Smartphone Household Wireless Electroencephalogram Hat

    Directory of Open Access Journals (Sweden)

    Harold Szu

    2013-01-01

    Full Text Available Rudimentary brain machine interface has existed for the gaming industry. Here, we propose a wireless, real-time, and smartphone-based electroencephalogram (EEG system for homecare applications. The system uses high-density dry electrodes and compressive sensing strategies to overcome conflicting requirements between spatial electrode density, temporal resolution, and spatiotemporal throughput rate. Spatial sparseness is addressed by close proximity between active electrodes and desired source locations and using an adaptive selection of N active among 10N passive electrodes to form m-organized random linear combinations of readouts, m≪N≪10N. Temporal sparseness is addressed via parallel frame differences in hardware. During the design phase, we took tethered laboratory EEG dataset and applied fuzzy logic to compute (a spatiotemporal average of larger magnitude EEG data centers in 0.3 second intervals and (b inside brainwave sources by Independent Component Analysis blind deconvolution without knowing the impulse response function. Our main contributions are the fidelity of quality wireless EEG data compared to original tethered data and the speed of compressive image recovery. We have compared our recovery of ill-posed inverse data against results using Block Sparse Code. Future work includes development of strategies to filter unwanted artifact from high-density EEGs (i.e., facial muscle-related events and wireless environmental electromagnetic interferences.

  20. Wearing more than one hat?

    DEFF Research Database (Denmark)

    Høgedahl, Laust Kristian; Ibsen, Flemming

    . But there is a big difference in the premises and conditions upon which collective industrial conflict proceeds when comparing the public and private sectors in Denmark. This article presents a critical analysis of the use of collective industrial conflicts in the Danish public sector in light of collective......This article investigates the use of collective industrial conflict in the public sector by analysing the Danish teacher lockout in 2013. The social partners in the public sector in Denmark (and the other Scandinavian countries) engage in negotiations and reach agreements regarding wages...... bargaining round and the teacher lockout in 2013. The article shows how the use of collective industrial conflicts in the public sector has a number of built-in systemic flaws, as the public employers are at one and the same time the budgetary authority and legislators. This is not a new finding, however...

  1. Tarih Algısı Bağlamında Postmodern Bir Anlatı: İstanbul Hatırası A Postmodern Narration in the Context of History Perception: İstanbul Hatırası

    Directory of Open Access Journals (Sweden)

    Mustafa AYDEMİR

    2012-09-01

    Full Text Available Detective novel, formed around an intelligently planned murder and a detective who tries to solve it and find the murderer, shows a significant improvement with the influence of Postmodernism, which rose in the second half of 20th Century. That improvement first shows its face in translation, then writing in Turkish Literature. The history of detective novel, which began to take its place inliterary history due to the emergence of crime and along withurbanization, is as old as the concept of crime history. Having aparticular history, it can be claimed that it prepared the ground for theemergence of novel. However, two major war, which happened in the20th century, has led to a rapid development of the detective novel, thebest way to tell the story of the crimes.Ahmet Ümit’s novel İstanbul Hatırası is important as it shows thechange of detective novel in Turkish novel. A real – up to date and anunreal – historical, two different engaging fictions are being narrated inthat detective novel. Beginning with the murder, a journey to thehistorical sites of Istanbul is made. In addition, the importances ofthese sites, which are close to be destroyed, are pointed out.In this study, after mentioning how detective novel emerged inWest and Turkish Literature and its historic development, Ahmet Ümit’sİstanbul Hatırası has been analyzed and postmodern features in thisnovel has been emphasized. With this method, postmoderncharacteristics of the novel has been taken care in terms of plot, time,place, characters and the classical elements of the novel has beenevaluated with a postmodernist approach. Zekice plânlanmış bir cinayet ve onu çözmeye, katili bulmaya çalışan bir dedektif etrafında şekillenen polisiye roman, 20. yüzyılın ikinci yarısında ortaya çıkan postmodernizmin de etkisiyle önemli bir gelişme gösterir. Bu gelişme, Türk edebiyatında önce çeviri, sonra da telif yoluyla kendini gösterir. Suçun ortaya

  2. hatü’l-İnsân (Pend-Nâme-i Enûşîrvân’ın Türkçe Bir Tercümesi A Turkish Translation of Râhatü’l-İnsân (Pend-Nâme-i Enûşîrvân

    Directory of Open Access Journals (Sweden)

    Müjgân ÇAKIR

    2012-09-01

    Full Text Available Islamic literatures include many texts on the justice and counsels of Sassanian ruler Nûşîrevân. One of these is a work of Persian Literature which recounts the counsels written on his crown and figures with the titles of “Râhatü’l-insân” or “Pend-nâme-i Enûşîrvân” in some sources. Rıza Kulı Han Hidayet states that the text belongs to Bedâyi‛-i Belhî; however the identity of the author is disputed. It is also argued that the “Şerîf-i Şair,” whose name appears in the introduction to the text edited by Charles Schefer in his work entitled Chrestomathie Persane, is Ebû Şerîf Muhalledi-yi Gurgânî. Râhatü’l-insân has manuscripts in Turkish libraries. This article treats this work and its Turkish prose translation located at Süleymaniye Library, Fatih Section No. 5385 under the title “Pend-i Nûşîrevân-ı Âdil.” In this translation, the counsels written on the seventeen slices (küngüre of Nûşîrevân’s crown are given and it is told that this ruler had his crown put up somewhere appropriate every year for the soldiers to read his counsels. The purposes of Nûşîrevân’s counsels are proving a moral education to the public, directing his relations with his people as well as organizing the relations between them. Some of the counsels written on Nûşîrevân’s crown are as follows: “Respect the old and the weak, observe the rights of your parents, consult scholars before you do your business, have a command of your speech, do not betray trust, think before you speak.” The article will also treat some of the differences between the Persian manuscripts of the work and its Turkish translation. The transcription of the Turkish translation will be given. İslâmî edebiyatlarda Sasani hükümdarı Nûşîrevân’ın adaleti ve nasihatlarıyla ilgili birçok metin yazılmıştır. Bu metinlerden biri Fars Edebiyatı’nda onun tacının üzerinde yazılı olan nasihatları anlatan ve baz

  3. Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells.

    Science.gov (United States)

    Chen, Huang-Hui; Chang, Hsin-Huei; Chang, Jang-Yang; Tang, Ya-Chu; Cheng, Yung-Chi; Lin, Li-Mei; Cheng, Shu-Ying; Huang, Chih-Hsiang; Sun, Man-Wu; Chen, Chiung-Tong; Kuo, Ching-Chuan

    2017-12-01

    Nuclear factor erythroid-2-related factor 2 (NRF2) mainly regulates transcriptional activation through antioxidant-responsive elements (AREs) present in the promoters of NRF2 target genes. Recently, we found that NRF2 was overexpressed in a KB-derived drug-resistant cancer cell panel. In this panel, KB-7D cells, which show acquired resistance to topoisomerase II (Top II) poisons, exhibited the highest NRF2 activation. To investigate whether NRF2 directly contributed to acquired resistance against Top II poisons, we manipulated NRF2 by genetic and pharmacological approaches. The result demonstrated that silencing of NRF2 by RNA interference increased the sensitivity and treatment with NRF2 activator decreased the sensitivity of KB and KB-7D cells toward Top II poisons. Further, increased B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation activated NRF2 signaling in KB-7D cells. Moreover, increased binding of NRF2 to an ARE in the promoter of ATP-binding cassette subfamily C member 1 (ABCC1) directly contributed to Top II poison resistance. In addition, activation of NRF2 increased glutathione level and antioxidant capacity in KB-7D cells compared with that in KB cells; moreover, high glutathione level provided survival advantage to KB-7D cells. Our study is the first to show that aberrant NRF2 activation is via increased B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation, which increases the acquired resistance and promote the survival of Top II poison-resistant cancer cells. Importantly, NRF2 downstream effectors ABCC1 and glutathione directly contribute to acquired resistance and survival, respectively. These results suggest that blockade of NRF2 signaling may enhance therapeutic efficacy and reduce the survival of Top II poison-refractory tumors in clinical. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. MEŞÎHAT ARŞİV KAYITLARINDA HACI BEKTAŞ VELÎ VE BEKTAŞİLİK İLE İLGİLİ YAZILI KAYNAĞIN TESPİTİ [DETECTION OF WRITTEN SOURCES RELATED TO HAJI BEKTASH VELI AND BEKTASHI ORDER IN THE MEŞÎHAT ARCHIVE RECORDS

    Directory of Open Access Journals (Sweden)

    Uğur Sümer

    2017-09-01

    order to get their views on the information and demands included in the document, consists of three chapters and a conclusion part. The translation of the document dated 1920 was conducted by Asst. Prof. Ayhan Işık who detected the document in the meşîhat archive of the Istanbul Mufti’s Office, on behalf of the Turkish Culture and Haji Bektash Veli Association (Türk Kültürü ve Hacı Bektaş Velî Vakfı. The original images and transcription of the document is included in the appendix of the study. A simplified Turkish text which contains the following information was examined by our association and evaluated with the present written sources: Haji Bektash Veli’s genealogy, his spiritual lineage of Hodja Ahmed Yesevi, the education he received from Lokman Perende, his marital status being single, his following representatives who were not his children but companions, the number of dervishes he raised, the customary practices of the Bektashi order.

  5. Az ipar 4.0 fogalma, összetevői és hatása az értékláncra ----- Industry 4.0: definition, elements and effect on corporate value chain

    OpenAIRE

    Nagy, Judit

    2017-01-01

    Absztrakt: A tanulmány célja, hogy meghatározza az Ipar 4.0 fogalmát és mögé tekintsen, azaz magyarázatot találjon kialakulására, mozgatórugóira és legfőképpen, jelentőségére a vállalati értéklánc szempontjából. A dolgozat során rövid kitekintés erejéig foglalkozom makro, vagy gazdaságpolitikai kérdésekkel, de legfőképpen a vállalati szint vizsgálatára fókuszálok. A tanulmány megírása során azt tapasztaltam, hogy a szakirodalom is még ismerkedik a fogalommal, annak gazdasági hatásaival...

  6. Spitzer Secondary Eclipse Depths with Multiple Intrapixel Sensitivity Correction Methods Observations of WASP-13b, WASP-15b, WASP-16b, WASP-62b, and HAT-P-22b

    Science.gov (United States)

    Kilpatrick, Brian M.; Lewis, Nikole K.; Kataria, Tiffany; Deming, Drake; Ingalls, James G.; Krick, Jessica E.; Tucker, Gregory S.

    2017-01-01

    We measure the 4.5 μm thermal emission of five transiting hot Jupiters, WASP-13b, WASP-15b, WASP-16b, WASP-62b, and HAT-P-22b using channel 2 of the Infrared Array Camera (IRAC) on the Spitzer Space Telescope. Significant intrapixel sensitivity variations in Spitzer IRAC data require careful correction in order to achieve precision on the order of several hundred parts per million (ppm) for the measurement of exoplanet secondary eclipses. We determine eclipse depths by first correcting the raw data using three independent data reduction methods. The Pixel Gain Map (PMAP), Nearest Neighbors (NNBR), and Pixel Level Decorrelation (PLD) each correct for the intrapixel sensitivity effect in Spitzer photometric time-series observations. The results from each methodology are compared against each other to establish if they reach a statistically equivalent result in every case and to evaluate their ability to minimize uncertainty in the measurement. We find that all three methods produce reliable results. For every planet examined here NNBR and PLD produce results that are in statistical agreement. However, the PMAP method appears to produce results in slight disagreement in cases where the stellar centroid is not kept consistently on the most well characterized area of the detector. We evaluate the ability of each method to reduce the scatter in the residuals as well as in the correlated noise in the corrected data. The NNBR and PLD methods consistently minimize both white and red noise levels and should be considered reliable and consistent. The planets in this study span equilibrium temperatures from 1100 to 2000 K and have brightness temperatures that require either high albedo or efficient recirculation. However, it is possible that other processes such as clouds or disequilibrium chemistry may also be responsible for producing these brightness temperatures.

  7. The Parameterization of Top-Hat Particle Sensors with Microchannel-Plate-Based Detection Systems and its Application to the Fast Plasma Investigation on NASA's Magnetospheric MultiScale Mission

    Science.gov (United States)

    Gershman, Daniel J.; Gliese, Ulrik; Dorelli, John C.; Avanov, Levon A.; Barrie, Alexander C.; Chornay, Dennis J.; MacDonald, Elizabeth A.; Holland, Matthew P.; Pollock, Craig J.

    2015-01-01

    The most common instrument for low energy plasmas consists of a top-hat electrostatic analyzer geometry coupled with a microchannel-plate (MCP)-based detection system. While the electrostatic optics for such sensors are readily simulated and parameterized during the laboratory calibration process, the detection system is often less well characterized. Furthermore, due to finite resources, for large sensor suites such as the Fast Plasma Investigation (FPI) on NASA's Magnetospheric Multiscale (MMS) mission, calibration data are increasingly sparse. Measurements must be interpolated and extrapolated to understand instrument behavior for untestable operating modes and yet sensor inter-calibration is critical to mission success. To characterize instruments from a minimal set of parameters we have developed the first comprehensive mathematical description of both sensor electrostatic optics and particle detection systems. We include effects of MCP efficiency, gain, scattering, capacitive crosstalk, and charge cloud spreading at the detector output. Our parameterization enables the interpolation and extrapolation of instrument response to all relevant particle energies, detector high voltage settings, and polar angles from a small set of calibration data. We apply this model to the 32 sensor heads in the Dual Electron Sensor (DES) and 32 sensor heads in the Dual Ion Sensor (DIS) instruments on the 4 MMS observatories and use least squares fitting of calibration data to extract all key instrument parameters. Parameters that will evolve in flight, namely MCP gain, will be determined daily through application of this model to specifically tailored in-flight calibration activities, providing a robust characterization of sensor suite performance throughout mission lifetime. Beyond FPI, our model provides a valuable framework for the simulation and evaluation of future detection system designs and can be used to maximize instrument understanding with minimal calibration

  8. Indonesia Cohort of IO HAT Study to Evaluate Diabetes Management, Control, and Complications in Retrospective and Prospective Periods Among Insulin-Treated Patients with Type 1 and Type 2 Diabetes

    Directory of Open Access Journals (Sweden)

    Achmad Rudijanto

    2018-04-01

    Full Text Available Background: hypoglycemia is a major adverse event of insulin therapy for diabetes mellitus patients. The study was conducted to evaluate the incidence of hypoglycemia among insulin treated patients with type 1 diabetes mellitus (T1DM or type 2 diabetes mellitus (T2DM in the Indonesian cohort. Methods: this Indonesian cohort study consisted of retrospective and prospective evaluation of hypoglycemic episodes, using International Operations Hypoglycemia Assessment Tool (IO HAT in 374 patients with diabetes (T1DM; n=17 or T2DM; n=357. The patients of ≥18 years of age and treated with insulin for >12 months were selected for this study (ClinicalTrials.gov number: NCT02306681. Results: a total of 374 patients were enrolled in this study and completed SAQ1. All patients with T1DM (17 [100%], and 347 (97.2% patients with T2DM completed SAQ2. Almost all the patients in the 4-week prospective period reported at least one hypoglycemic event (T1DM 100%, T2DM 99.4% and the incidence rate of any hypoglycemia was 67.5 events per patient-year (PPY and 25.7 events PPY for T1DM and T2DM patients, respectively. Among patients with T1DM and T2DM, 5.9% and 36.4%, respectively, did not know what hypoglycemia was at baseline, also high proportion of patients had impaired hypoglycemic awareness in the study (82.4% and 62.7%, respectively. Conclusion: overall, high proportion of patients reported hypoglycemic events in the prospective period indicating under reporting during the retrospective period due to recall bias. Therefore, there is a need for patient education program to improve the awareness of hypoglycemia in diabetes patient in Indonesia.

  9. SPITZER SECONDARY ECLIPSE DEPTHS WITH MULTIPLE INTRAPIXEL SENSITIVITY CORRECTION METHODS OBSERVATIONS OF WASP-13b, WASP-15b, WASP-16b, WASP-62b, AND HAT-P-22b

    Energy Technology Data Exchange (ETDEWEB)

    Kilpatrick, Brian M.; Tucker, Gregory S. [Department of Physics, Box 1843, Brown University, Providence, RI 02904 (United States); Lewis, Nikole K. [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Kataria, Tiffany [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Deming, Drake [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Ingalls, James G.; Krick, Jessica E., E-mail: brian_kilpatrick@brown.edu, E-mail: nlewis@stsci.org, E-mail: tiffany.kataria@jpl.nasa.gov, E-mail: ddeming@astro.umd.edu, E-mail: krick@ipac.caltech.edu [Spitzer Science Center, Infrared Processing and Analysis Center, California Institute of Technology, Mail Code 220-6, Pasadena, CA 91125 (United States)

    2017-01-01

    We measure the 4.5 μ m thermal emission of five transiting hot Jupiters, WASP-13b, WASP-15b, WASP-16b, WASP-62b, and HAT-P-22b using channel 2 of the Infrared Array Camera (IRAC) on the Spitzer Space Telescope . Significant intrapixel sensitivity variations in Spitzer IRAC data require careful correction in order to achieve precision on the order of several hundred parts per million (ppm) for the measurement of exoplanet secondary eclipses. We determine eclipse depths by first correcting the raw data using three independent data reduction methods. The Pixel Gain Map (PMAP), Nearest Neighbors (NNBR), and Pixel Level Decorrelation (PLD) each correct for the intrapixel sensitivity effect in Spitzer photometric time-series observations. The results from each methodology are compared against each other to establish if they reach a statistically equivalent result in every case and to evaluate their ability to minimize uncertainty in the measurement. We find that all three methods produce reliable results. For every planet examined here NNBR and PLD produce results that are in statistical agreement. However, the PMAP method appears to produce results in slight disagreement in cases where the stellar centroid is not kept consistently on the most well characterized area of the detector. We evaluate the ability of each method to reduce the scatter in the residuals as well as in the correlated noise in the corrected data. The NNBR and PLD methods consistently minimize both white and red noise levels and should be considered reliable and consistent. The planets in this study span equilibrium temperatures from 1100 to 2000 K and have brightness temperatures that require either high albedo or efficient recirculation. However, it is possible that other processes such as clouds or disequilibrium chemistry may also be responsible for producing these brightness temperatures.

  10. ALICE doffs hat to two companies

    CERN Multimedia

    2007-01-01

    During the fifth annual ALICE Industrial Awards ceremony, the ALICE Collaboration honoured two companies for their outstanding contributions to the construction of the experiment.For the past five years, the ALICE collaboration has been presenting its industrial partners with awards for meeting demanding or unusual requirements, for excellence in design or execution, for delivery on-time and on-budget and for outstanding cooperation. This year, on 9 March, ALICE presented awards to two companies for their exceptional performance. From left to right: Kees Oskamp (ALICE SSD), Arie de Haas (ALICE SSD), Gert-Jan Nooren (ALICE SSD), Shon Shmuel (FIBERNET), Yehuda Mor-Yosef (FIBERNET), Hans Boggild (ALICE), Jurgen Schukraft (ALICE Spokesperson), Catherine Decosse (ALICE) and Jean-Robert Lutz (ALICE SSD). FIBERNET Ltd., based in Yokneam, Israel, was rewarded for the excellent and timely assembly of the Silicon Strip Detector boards (SSD) of the Inner Tracking System with cable connections. Special low-mass cables, ...

  11. Jede Nation hat eben ihre eigen Wahrheit

    Czech Academy of Sciences Publication Activity Database

    Stach, Stephan

    Č. 118 (2016), s. 13 ISSN 0174-4909 R&D Projects: GA ČR(CZ) GJ16-01775Y Institutional support: RVO:68378114 Keywords : politics of memory * Museum of the Second World War * Poland Subject RIV: AB - History

  12. Verbreitung rassistischen Gedankenguts – Meinungsfreiheit hat Grenzen

    Directory of Open Access Journals (Sweden)

    Hendrik Cremer

    2017-12-01

    Full Text Available Die Meinungsfreiheit ist ein zentrales Menschenrecht, das – so formuliert es das Bundesverfassungsgericht – für die freiheitlich-demokratische Staatsordnung „schlechthin konstituierend“ ist. Die Meinungsfreiheit ist jedoch kein Freifahrtschein für rassistische Diffamierungen und Parolen. Dies ergibt sich aus der grund- und menschenrechtlichen Schutzpflicht des Staates, die Bevölkerung vor rassistischer Propaganda zu schützen.

  13. Hats off to the particle suppliers

    CERN Multimedia

    Rolf Heuer

    2010-01-01

    A couple of weeks into the LHC’s first high energy physics run, and we’ve already got an impressive story to tell. Long fills for physics are becoming routine, luminosity scans have increased the collision rate. The operators are becoming adept at squeezing the beams ever smaller, and higher intensity studies are progressing well. With the experiments, it’s the same story.   Following the plots that the spokespersons were able to show on 30 March after just one hour of running, the experiments have already made significant inroads into re-measuring all the Standard Model parameters necessary to ensure that they fully understand their detectors before any new discoveries can be announced. It’s impressive stuff, and the attention is rightly on the LHC and its experiments. But we shouldn’t lose sight of the fact that all this relies on the seamless operation of many other systems. Starting from a deceptively simple bottle of hydrogen, an LHC proton ...

  14. Wer hat Recht? Who Has Legal Rights?

    Directory of Open Access Journals (Sweden)

    Swantje Lichtenstein

    2004-07-01

    Full Text Available Der Zusammenhang zwischen sexueller Differenz und deren juristischen Folgen wird in der Wiener Studie näher beleuchtet. Auch wenn die Zeiten der offenen Diskriminierung vorüber zu sein scheinen, die Ungleichheit vor dem Recht bleibt bestehen. Noch immer liegen die Verdienste von Frauen deutlich unter denen von Männern, immer noch wird – auch gesetzlich – der Bereich des Privaten als genuin weiblicher verstanden, die Öffentlichkeit dagegen ist männlich. Hier setzen die Fragen zur gerechten Machtverteilung an, die der Band behandelt. Die Interdependenz von gesellschaftlicher Veränderung und rechtlichem Wandel wird von Elisabeth Holzleithner anhand verschiedener Diskurse vorgeführt.The connection between sexual difference and its juridicial consequences is examined more closely in this Viennese study. Even when the times of open discrimination seem to have subsided, inequality in the legal sphere still remains. Women’s incomes are still distinctly below those of men. The private sphere is still understood—also legally—as being genuinely feminine, whereas the public sphere is considered masculine. The questions considered in the volume regarding the just distribution of power stem from these issues. The interdependence of societal change and legal transformation is presented by Elisabeth Holzleithner on the basis of various discourses.

  15. Computer Security: White hats for CERN

    CERN Multimedia

    Stefan Lueders, Computer Security Team

    2016-01-01

    CERN is under attack. Permanently. Even right now. In particular, the CERN web environment, with its thousands of websites and millions of webpages, is a popular target for evil-doers as well as for security researchers.   Usually, their attacks are unsuccessful and fade away over time. Sometimes, however, they are successful and manage to break into a CERN website or web server… It is imperative that we learn about our weaknesses before others do – and fix them! Hackers with bad intentions are usually named “black hats” as they misuse their power to cause destruction or downtime via any weakness they can find. “Grey hats” are more moderate and might just have some fun with the weaknesses they find, for example by putting naked teddy bears or a personal message (such as “I hacked U”) on the compromised website. Last but not least, “white hats” report their findings directly to us and suggest that...

  16. Getting started with Red Hat Enterprise virtualization

    CERN Document Server

    Subramanian, Pradeep

    2014-01-01

    If you are a system administrator who is interested in implementing and managing open source virtualization infrastructures, this is the book for you. A basic knowledge of virtualization and basic Linux command line experience is needed.

  17. Hats off to CERN's Master of Apprenticeships!

    CERN Multimedia

    2004-01-01

    Roland Gay of the HR Department (at right) recently received a special diploma from the Geneva Industrial Union (UIG). Presented by Carlo Lamprecht, Head of the Department of Economy, Employment and External Affairs of the State of Geneva, the diploma was awarded in recognition of the 199 CERN apprentices Roland has guided through the Certificat Fédéral de Capacité (CFC), an end-of-apprenticeship certificate awarded by the Cantonal authorities. Roland will be retiring in December 2004 after 37 years of service, 32 of which he spent in the role of apprenticeship supervisor.

  18. Estudi i anàlisi del funcionament del carril bus-VAO de la C-58. Propostes per millorar el seu funcionament

    OpenAIRE

    Torras i Guitart, Alex

    2015-01-01

    En aquest treball he repassat diferents aspectes de mobilitat, tot veient quin és el flux de població que es dóna diàriament dins de l'àrea metropolitana; concretament, entre les comarques del Vallès Occidental i el Barcelonès. Així doncs, s'ha pogut analitzar més a fons, no només la població que es desplaça diàriament, sinó també com es distribueix aquesta. És a dir, mirant quines vies utiltzen, en quines franges horàries es donen els majors nivells de trànsit, etc. Tot això ve degut a la p...

  19. Fedora Linux A Complete Guide to Red Hat's Community Distribution

    CERN Document Server

    Tyler, Chris

    2009-01-01

    Whether you are running the stable version of Fedora Core or bleeding-edge Rawhide releases, this book has something for every level of user. The modular, lab-based approach not only shows you how things work--but also explains why--and provides you with the answers you need to get up and running with Fedora Linux.

  20. Census taking in the hat: FRW/CFT duality

    International Nuclear Information System (INIS)

    Sekino, Yasuhiro; Susskind, Leonard

    2009-01-01

    In this paper a holographic description of eternal inflation is developed. We focus on the description of an open Friedmann-Robertson-Walker (FRW) universe that results from a tunneling event in which a false vacuum with positive vacuum energy decays to a supersymmetric vacuum with vanishing cosmological constant. The observations of a 'census taker' in the final vacuum can be organized into a holographic dual conformal field theory that lives on the asymptotic boundary of space. We refer to this bulk-boundary correspondence as FRW/CFT duality. The dual conformal field theory (CFT) is a Euclidean two-dimensional theory that includes a Liouville 2D gravity sector describing geometric fluctuations of the boundary. The renormalization-group flow of the theory is richer than in the AdS/CFT correspondence, and generates two space-time dimensions--one spacelike and one timelike. We discuss a number of phenomena such as bubble collisions, and the Garriga, Guth Vilenkin 'persistence of memory', from the dual viewpoint.

  1. Big Hat, No Cattle: Managing Human Resources, Part 2.

    Science.gov (United States)

    Skinner, Wickham

    1982-01-01

    The author discusses why business has difficulty in motivating its employees and proposes a new approach to developing human resources. Discusses mistaken premises, personnel and supervision, setting a long-term goal, changing management's philosophy, and selling human resource development as a company priority. (CT)

  2. Big Hat, No Cattle: Managing Human Resources, Part 1.

    Science.gov (United States)

    Skinner, Wickham

    1982-01-01

    Presents an in-depth analysis of problems and a suggested approach to developing human resources which goes beyond identifying symptoms and provides a comprehensive perspective for building an effective work force. (JOW)

  3. The White-hat Bot: A Novel Botnet Defense Strategy

    Science.gov (United States)

    2012-06-14

    etc. I will briefly discuss one common exploit here. One fraudulent activity 4 perpetuated by botnets involves ad services such as Google’s AdSense ...which pays website owners revenue for posting the AdSense banner on their web site (Google, 2012). The AdSense banner displays messages from...botmaster creates a bot that is programmed to visit the botmaster’s own websites to click on the advertisements displayed in the AdSense banners. Since

  4. Computer Security: Join the CERN WhiteHat Challenge!

    CERN Multimedia

    Computer Security Team

    2014-01-01

    Over the past couple of months, several CERN users have reported vulnerabilities they have found in computing services and servers running at CERN. All were relevant, many were interesting and a few even surprising. Spotting weaknesses and areas for improvement before malicious people can exploit them is paramount. It helps protect the operation of our accelerators and experiments as well as the reputation of the Organization. Therefore, we would like to express our gratitude to those people for having reported these weaknesses! Great job and well done!   Seizing the opportunity, we would like to reopen the hunt for bugs, vulnerabilities and insecure configurations of CERN applications, websites and devices. You might recall we ran a similar initiative (“Hide & Seek”) in 2012 where we asked you to sift through CERN’s webpages and send us those that hold sensitive and confidential information. Quite a number of juicy documents were found and subsequently remov...

  5. Middle School Girls Sample "Hard Hat" Life at Construction Camp

    Science.gov (United States)

    Brown, Aneeta

    2013-01-01

    On a Monday morning in July, a fan as tall as a refrigerator churned noisily in the cavernous classroom. As the outdoor temperature crept higher, teenage girls wearing hardhats and safety glasses wiped perspiration and sawdust from their faces. This was not a field trip. This was the second hour of camp at Ranken Technical College in St. Louis,…

  6. Antioxidant mechanism of bilirubin: both HAT and SET are possible

    International Nuclear Information System (INIS)

    Adhikari, Soumyakanti; Joshi, Ravi; Mukherjee, Tulsi

    2008-01-01

    Bilirubin (BR) plays two extreme roles in physiology, one hand it is a toxic metabolite while at micromolar concentration it acts as antioxidant. It has been observed that hydroxyl, glutathiyl and Linoleic peroxyl radicals abstract hydrogen atom from bilirubin, whereas N 3 , Br 2 , CCl 3 OO, NO 2 radicals react via single electron transfer action. Our study demonstrates that oxidation of bilirubin occurs via both hydrogen atom transfer and single electron transfer depending on the nature of the radical. (author)

  7. Hard-Hat Detection for Construction Safety Visualization

    OpenAIRE

    Shrestha, Kishor; Shrestha, Pramen P.; Bajracharya, Dinesh; Yfantis, Evangelos A.

    2015-01-01

    In 2012, 775 fatalities were recorded, and many more were injured at construction sites in the United States. Of these, 415 fatalities (54%) were due to fall, slips, and trips as well as being struck by falling objects. In order to decrease fatalities at construction sites to these types of events, the Occupational Safety and Health Administration (OSHA) provides Fall Prevention and OSHA-10 trainings to construction workers. Moreover, safety personnel monitor whether the workers use personal ...

  8. Welches Geschlecht hat die Avantgarde? Which gender has the Avantgarde?

    Directory of Open Access Journals (Sweden)

    Gertrud Lehnert

    2000-07-01

    Full Text Available Das Buch betrachtet das Theater der französischen und amerikanischen ‚Avantgarde‘ der Moderne und Postmoderne unter dem Aspekt des Geschlechts: Welcher Verfahren bedient sich avantgardistische Kunst, ist avantgardistische Kunst in geschlechtlicher Hinsicht restriktiv, oder ermöglicht sie die subversive feministische oder auch lesbisch-schwule Ausformung spezifischer Formen?In this book the French and American avantgarde theatre of the modern and postmodern period is analysed from aspects of gender. The questions raised are which processes serve to develop avantgarde art, whether avantgarde art is restrictive with regard to gender, or whether it enables a subversive feminist or specific lesbian/gay forms of theatre?

  9. Veils, Caps and Hats: The Language of Headgear between the ...

    African Journals Online (AJOL)

    L'autrice tratta l'uso del copricapo nel Medievo e all'inizio dell'Età moderna, con continui riferimenti ai testi di San Paolo e alle prediche quattrocentesche dei frati minori dell'osservanza francescana. Viene altresì considerato l'impiego della mantellina, del velo e del piumaggio, tipiche della moda del tempo, in relazione alle ...

  10. Black Hats and White Hats: The Effect of Organizational Culture and Institutional Identity on the Twenty-third Air Force

    Science.gov (United States)

    2006-12-01

    the two communities, their institutional histories have played a significant role in their organizational development. According to Col Ken Pribyla...Low IIIs, UH-60 Blackhawks (the Army’s first operational company of UH-60s), CH-47C Chi- nooks from the 101st Airborne Division, and OH-6 Loach ...Blackhawks (the Army’s first operational company of UH-60s), CH-47C Chinooks from the 101st Airborne Division, and OH-6 Loach helicopters that could

  11. Black Hats and White Hats: The Effect of Organizational Culture and Institutional Identity on the Twenty-third Air Force

    National Research Council Canada - National Science Library

    Koskinas, Ioannis

    2006-01-01

    .... Although brief, the Twenty-third Air Force's experience provides sufficient data for a thorough analysis of the effect of organizational culture and institutional agendas on the evolution of a nascent organization...

  12. Görsellerle Desteklenmiş Altı Şapka Düşünme Tekniğinin Öğrencilerin Konuşma Becerilerini Geliştirmesine Etkisi Six Thinking Hats Technique Supported Visuals Effects of Students' Speaking Skills Develop

    Directory of Open Access Journals (Sweden)

    Salih ORHAN

    2012-09-01

    Full Text Available to express oneself to communicate as a society to provide others. Inthis sense, individuals benefit from the ability to talk in daily life themost. Speaking a language skill can be developed which are used in avariety of methods to be used more effectively.The main objective of this study, elementary school studentsimprove their speaking skills supported by visuals than the traditionalmethod to determine the effect of six hat thinking techniques. Theprimary purpose of research 8th grade students for a period of fourweeks 'of Science and Technology' theme applied The data "SpeakingObservation Form" (Orhan, 2010 collected the data. Visuals supportedby the experimental group, while speaking activities, speaking in thecontrol group were carried out according to conventional method. Inthis context, information about the method, first given to students inthe experimental group, how to implement this method, the researcherexplained to the students by students. Then, for each color of the sixhat thinking techniques were made in the speech handed out picturesto students. The data were evaluated with SPSS 19.0, to compare withthose of the pre-test and post-test "for the measurements associatedwith the Wilcoxon signed Ranks Test" was used. As a result 'speechrules, Effective use of voice and body language, be prepared to makespeeches, their speech evaluation' goals and achievements, such as thedevelopment of speech in the Turkish Course Programme of theexperimental group students was found to be more successful than thecontrol group students and and a variety of applications related toproposing and speaking skills teachers can use this method unlessotherwise indicated. Eğitimin en temel hedeflerinden biri de insanın kendisini ifade edebilmesini ve toplumsal bir varlık olarak toplumun diğer bireyleriyle iletişim kurabilmesini sağlamaktır. Bu anlamda bireyler günlük hayatta en çok konuşma becerisinden faydalanmaktadırlar. Geliştirilebilir bir

  13. The Organization and Management of the Virtual Astronomical Observatory

    Science.gov (United States)

    Berriman, G. Bruce; Hanisch, Robert J.; Lazio, T. Joseph W.; Szalay, Alexander; Fabbiano, Giussepina

    2012-01-01

    The U.S. Virtual Astronomical Observatory (VAO; http://www.us-vao.org/) has been in operation since May 2010. Its goal is to enable new science through efficient integration of distributed multi-wavelength data. This paper describes the management and organization of the VAO, and emphasizes the techniques used to ensure efficiency in a distributed organization. Management methods include using an annual program plan as the basis for establishing contracts with member organizations, regular communication, and monitoring of processes.

  14. Enzymatic synthesis of vanillin

    NARCIS (Netherlands)

    van den Heuvel, RHH; Fraaije, MW; Laane, C; van Berkel, WJH; Heuvel, Robert H.H. van den; Berkel, Willem J.H. van

    Due to increasing interest in natural vanillin, two enzymatic routes for the synthesis of vanillin were developed. The flavoprotein vanillyl alcohol oxidase (VAO) acts on a wide range of phenolic compounds and converts both creosol and vanillylamine to vanillin with high yield. The VAO-mediated

  15. Enzymatic synthesis of vanillin

    NARCIS (Netherlands)

    Heuvel, van den R.H.H.; Fraaije, M.W.; Laane, C.; Berkel, van W.J.H.

    2001-01-01

    Due to increasing interest in natural vanillin, two enzymatic routes for the synthesis of vanillin were developed. The flavoprotein vanillyl alcohol oxidase (VAO) acts on a wide range of phenolic compounds and converts both creosol and vanillylamine to vanillin with high yield. The VAO-mediated

  16. Toward a 21st-Century Understanding of Humans' Relation to Nature: Two Hats?

    Science.gov (United States)

    Rennie, Scott

    2008-01-01

    From its inception, environmental education (EE) has shouldered the imposition of impartiality on its methods and practices. Considering the reality of global climate change, the author urges the adoption of the more accurate theory of humans' relation to the natural world. This theory necessitates partiality toward healthy, functioning natural…

  17. Moccasins into Slippers: Woodlands Indian Hats, Bags, and Shoes in Tradition and Transformation.

    Science.gov (United States)

    Phillips, Ruth B.

    1990-01-01

    In the mid-nineteenth century, an abrupt transformation occurred in textiles and other art forms of northeastern Woodlands Indians. Trade, tourism, and survival needs sparked changes in materials used and garment types produced, as well as substitution of a new vocabulary of floral imagery for "pagan" iconographic traditions. (SV)

  18. Visual structure analysis of compound reliefs of milli hats used by ...

    African Journals Online (AJOL)

    The major part of Kurdish arts has been traditionally created by women. These women have inherited old distant memories generations after generations and will also leave them as inheritance to succeeding generations. The most significant of these arts is the art of knitting which bears significant importance amongst ...

  19. Hard Hats, Octopuses and Rubber Boots- Operational Managers in Building Processes

    DEFF Research Database (Denmark)

    Koch, Christian

    2004-01-01

    This paper discusses Operation management (OM) in the production of buildings. It is initially contended that OM needs to be improved, from a theoretical and practical perspective. Departing from a criticism of present modeling and management of processes it is suggested to develop an understanding...... of the steps and interdependencies in the process. The field study shows a vast amount of interruptions in operational managers work at the building site. The site managers studied typically worked with four main activities and were interrupted some 126 times during a workday. The prime reason...

  20. "...dass man einen festen Glauben daran hat, dass das jetzige System die Rettung sei"

    DEFF Research Database (Denmark)

    Lammers, Karl Christian

    2011-01-01

    Undersøgelse af den danske gesandt i Berlin Herluf Zahles beretning om og vurdering af forholdet mellem Hitler og tyskerne.......Undersøgelse af den danske gesandt i Berlin Herluf Zahles beretning om og vurdering af forholdet mellem Hitler og tyskerne....

  1. Clare Soper's Hat: New Education Fellowship Correspondence between Bloomsbury and New Zealand, 1938-1946

    Science.gov (United States)

    Middleton, Sue

    2013-01-01

    Broadening horizons beyond nations, transnational histories trace global flows connecting people and places. Historians have studied the New Education Fellowship (NEF) as a global network. Focused within the nation, research on New Zealand's involvement with NEF has emphasised how its activities before the Second World War impacted on the Labour…

  2. CALLIGRAPHY OF STACKED FRUIT IN ART OF CALLIGRAPHY / HAT SANATINDA MEYVE ISTIFLI HATLAR

    Directory of Open Access Journals (Sweden)

    Dr. Zübeyde Cihan ÖZSAYINER

    2008-10-01

    Full Text Available Calligraphy with stacked fruit in the art ofcalligraphy In Turkish culture fruit has created afundamental element used lovingly in architecture,calligraphy, miniatures, woodwork, metalwork, porcelain art, carpets, towels, edging, printed cloth, embroidery,folk art and gravestones. As a result of studies, it hasbeen shown that fruit has the symbolic meanings ofimmortality, the existence that is the core of something, ajewel and truth. It is seen that the symbolisms of fruit byitself changes according to societies. The apple becamethe fruit of the tree in paradise and the “golden apple” isthe symbol of immortality. The grape symbolizes autumn,the pomegranate bountifulness, reproduction, maternityand birth. As a result of my research in the art ofcalligraphy it has been proven that there are manuscriptsreflecting religious and mystic subjects have beenstacked neatly in the forms of pears, apples andpomegranate. In the Turkish Foundation CalligraphicArts Museum, the only such one in Turkey and in theworld there are three examples of calligraphy neatlystacked in pear form. It seems that the stacked fruit inthe form of pears, apples and pomegranates and writtenin various techniques were lovingly used by calligrapherswho had great creative power, sought change in theTurkish art of calligraphy and worked in religious andmystic circles.

  3. Das Recht auf Vergessenwerden als Menschenrecht : Hat Menschenwürde im Informationszeitalter Zukunft?

    NARCIS (Netherlands)

    Gstrein, Oskar Josef

    2016-01-01

    The processing of personal data is becoming ubiquitous and affects almost all areas of society. At the same time the possibility to permanently analyze personal behavior threatens to become an unbearable burden for the future development of the individual. Faced with a world of informational

  4. Cylinders out of a top hat: counts-in-cells for projected densities

    Science.gov (United States)

    Uhlemann, Cora; Pichon, Christophe; Codis, Sandrine; L'Huillier, Benjamin; Kim, Juhan; Bernardeau, Francis; Park, Changbom; Prunet, Simon

    2018-06-01

    Large deviation statistics is implemented to predict the statistics of cosmic densities in cylinders applicable to photometric surveys. It yields few per cent accurate analytical predictions for the one-point probability distribution function (PDF) of densities in concentric or compensated cylinders; and also captures the density dependence of their angular clustering (cylinder bias). All predictions are found to be in excellent agreement with the cosmological simulation Horizon Run 4 in the quasi-linear regime where standard perturbation theory normally breaks down. These results are combined with a simple local bias model that relates dark matter and tracer densities in cylinders and validated on simulated halo catalogues. This formalism can be used to probe cosmology with existing and upcoming photometric surveys like DES, Euclid or WFIRST containing billions of galaxies.

  5. Toward a common identity for relationally oriented clinicians: a place to hang one's hat.

    Science.gov (United States)

    Markin, Rayna D

    2014-09-01

    The goal of this special section is to work toward establishing a common identity for relationally inclined clinicians across proscribed theoretical orientations, facilitating a shared identity among diverse psychotherapists while placing a spotlight on relationship research. This article discusses the need for a more coherent and less polarizing professional identity for psychotherapists and why a more universal relational orientation to psychotherapy is timely given the current state of psychotherapy practice and research. Lastly, common relational themes that run throughout the diverse treatment paradigms presented in this special section are discussed, framing what it means to be a relational psychotherapist while hopefully providing some direction for future research and clinical training. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  6. Hat das humane Wachtumshormon (hGH eine Relevanz in der Kontrolle der penilen Erektion?

    Directory of Open Access Journals (Sweden)

    Ückert St

    2003-01-01

    Full Text Available Allgemeines: Schon seit langem wird die Frage einer Beteiligung des Hypophysenhormons Human Growth Hormone (Wachstumshormon, hGH, GH an der Kontrolle der sexuellen Maturation und der Reproduktionsfunktion des Menschen diskutiert. Die Symptome eines GH-Defizits beim Mann sind u. a. allgemeine Antriebslosigkeit, Oligo- oder Azoospermie, eine Verminderung der Libido sowie eine Beeinträchtigung der normalen Erektionsfähigkeit. Es wird vermutet, daß die biologischen Effekte des GH eine durch das Somatomedin Insulin-like Growth Factor 1 (IGF-1 vermittelte Stimulation der Produktion von Stickoxid (NO durch die endotheliale und neuronale Form des Enzyms NO-Synthase einschließen. So konnte gezeigt werden, daß physiologische Konzentrationen von GH den adrenergen Tonus isolierter Streifenpräparate humaner Schwellkörpermuskulatur antagonisieren und den Gewebegehalt des Second Messengers cGMP erhöhen. Im Rahmen dieser Studie haben wir in einem Kollektiv gesunder Männer und in einer Gruppe von Patienten mit erektiler Dysfunktion (ED die systemischen und cavernösen Serumkonzentrationen von GH während verschiedener peniler Funktionszustände, d. h. verschiedener Stadien der sexuellen Erregung, untersucht. Methoden: 35 gesunden männlichen Probanden und 45 Patienten mit einer ED organogener oder psychogener Genese wurden während der penilen Flakzidität, Tumeszenz, Rigidität - dieses Stadium wurde nur von den Gesunden erreicht - und Detumeszenz zeitgleich Blutproben aus einer Cubitalvene und dem Corpus cavernosum penis entnommen. Tumeszenz und Rigidität wurden durch visuelle und taktile Stimulation ausgelöst. Die Quantifizierung von GH in Aliquots der Serumfraktionen erfolgte mit immunradiometrischen Methoden (IRMA. Ergebnisse: In der Gruppe der gesunden Männer stieg die mittlere systemische und cavernöse Serumkonzentration von GH während der Tumeszenz an, während in den Phasen der Rigidität und Detumeszenz eine Abnahme registriert wurde. Eine Unterteilung des Patientenkollektivs nach einer psychogenen und organogenen Genese der ED ergab, daß die mittleren GH-Konzentrationen im Blut der psychogenen Patienten in den Stadien der Flakzidität, Tumeszenz und Detumeszenz sich nicht wesentlich von denen im Serum der gesunden Männer unterschieden. Die GH-Spiegel im systemischen und cavernösen Blut der organogenen Patienten waren nicht nur deutlich erniedrigt, auch eine Erhöhung der mittleren GH-Serumkonzentration während der penilen Tumeszenz wurde nur in geringem Maße registriert. Schlußfolgerung: Unsere Resultate lassen vermuten, daß dem GH wahrscheinlich eine zentrale Rolle in der Aufrechterhaltung der erektilen Funktion zukommt und daß eine Störung der normalen GH-Sekretion zur Manifestation einer ED beitragen kann.

  7. Who has priority during the regulation?; Wer hat Vorrang beim Abregeln?

    Energy Technology Data Exchange (ETDEWEB)

    Janzing, Bernward

    2013-04-15

    The remote control of wind power plants by direct marketers raises questions - not only on the technology, but also on the hierarchy of actors. From the technical perspective, the current practice of feed-in is not particularly well developed. So far, the regulation of wind turbines via radio ripple control is carried out in stages to 60, 30 and 0 %. The traditional ripple control technology does not send a message back to the sender if the wind turbine has received the signal and reacts to it. Smart meter and digital control technology can provide assistance in this case. Consequences for the plant safety result from this regulation: The performance of a wind turbine shall be reduced only with a gradient of ten percent of the initial output per minute. If the data transfer is interrupted, the reduction of the power will be closed automatically after 30 minutes.

  8. Nuclear phase-out in Switzerland. Rationality first; Atomausstieg in der Schweiz. Vernunft hat Vorfahrt

    Energy Technology Data Exchange (ETDEWEB)

    Leidinger, Tobias [Luther Rechtsanwaltsgesellschaft, Duesseldorf (Germany).

    2017-05-15

    Just a few months ago, the Swiss voters have rejected the initiative of the Green Party to accelerate the nuclear phase-out in Switzerland with an impressive majority. Once again, it becomes clear that in Switzerland on issues of energy policy rationality and not ideology is leading. With their vote against an accelerated nuclear phase-out, the Swiss citizens underlined that they have no sympathy for radical, ideologically proposals for solutions, which on closer inspection are expensive, risky and immature. The majority has understood that the extensive expansion of renewable energies and power grids is burdened with numerous risks and uncertainties.

  9. Score a Facilities Hat Trick: Strategic Goals for Successful Hiring, Training, and Team Commitment

    Science.gov (United States)

    Loy, Darcy

    2012-01-01

    Granted, it might be a bit of a stretch to find comparable attributes between an ice hockey team and facilities management organizations. However, if you are open-minded to the possibility and begin to analyze each of these entities, you will find there are some distinct similarities. Ice hockey is a fast-paced and ever-changing game, much like a…

  10. Stimulation of cytolytic T lymphocytes by azaguanine-resistant mouse tumor cells in selective hat medium

    International Nuclear Information System (INIS)

    Snick, J. van; Uyttenhove, C.; Pel, A. van; Boon, T.

    1981-01-01

    Primed syngeneic or umprimed allogeneic mouse spleen cells were stimulated with azaguanine-resistant P815 tumor cells that were killed by the addition of aminopterin to the stimulation medium. The recovery of lymphocytes and their cytolytic activity and specificity were similar to those obtained after stimulation with irradiated cells. This method conveniently replaces the inactivation of stimulatory cells by irradiation or mitomycin treatment. Moreover, it has the advantage of inactivating not only the stimulatory cells but also the tumor cells that often contaminate the spleens of tumor-bearing animals, provided these animals have been inoculated with azaguanine-resistant tumor cell mutants. (Auth.)

  11. "Die Nato hat einen grossen Fehler begangen" / Toomas Hendrik Ilves ; interv. Ansgar Graw

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2008-01-01

    Eesti president räägib sõjalistest kokkupõrgetest Gruusias, vajadusest uue rahvusvahelise julgeolekustruktuuri järele, ootustest rahvusvahelise üldsuse suhtes, Balti riikide julgeolekust ning kritiseerib NATO otsust mitte anda Gruusiale NATO liikmelisuse tegevuskava

  12. Aging Trajectories in Different Body Systems Share Common Environmental Etiology: The Healthy Aging Twin Study (HATS).

    Science.gov (United States)

    Moayyeri, Alireza; Hart, Deborah J; Snieder, Harold; Hammond, Christopher J; Spector, Timothy D; Steves, Claire J

    2016-02-01

    Little is known about the extent to which aging trajectories of different body systems share common sources of variance. We here present a large twin study investigating the trajectories of change in five systems: cardiovascular, respiratory, skeletal, morphometric, and metabolic. Longitudinal clinical data were collected on 3,508 female twins in the TwinsUK registry (complete pairs:740 monozygotic (MZ), 986 dizygotic (DZ), mean age at entry 48.9 ± 10.4, range 18-75 years; mean follow-up 10.2 ± 2.8 years, range 4-17.8 years). Panel data on multiple age-related variables were used to estimate biological ages for each individual at each time point, in linear mixed effects models. A weighted average approach was used to combine variables within predefined body system groups. Aging trajectories for each system in each individual were then constructed using linear modeling. Multivariate structural equation modeling of these aging trajectories showed low genetic effects (heritability), ranging from 2% in metabolic aging to 22% in cardiovascular aging. However, we found a significant effect of shared environmental factors on the variations in aging trajectories in cardiovascular (54%), skeletal (34%), morphometric (53%), and metabolic systems (53%). The remainder was due to environmental factors unique to each individual plus error. Multivariate Cholesky decomposition showed that among aging trajectories for various body systems there were significant and substantial correlations between the unique environmental latent factors as well as shared environmental factors. However, there was no evidence for a single common factor for aging. This study, the first of its kind in aging, suggests that diverse organ systems share non-genetic sources of variance for aging trajectories. Confirmatory studies are needed using population-based twin cohorts and alternative methods of handling missing data.

  13. On being an individual, or: the man in the red hat.

    Science.gov (United States)

    Scriver, C R

    If health is a state of equilibrium between intrinsic (genetic) functions and extrinsic (environmental) factors, then disease can be defined as a state of disequilibrium. Medicine has traditionally emphasized extrinsic factors in the origin of human diseases; medical genetics is concerned with the intrinsic factors (mutations) that either yield disease in the universal environment or constitute states of risk for individuals in particular (or universal) enviroments. Genetic screening is a process that defines specific risks for particular individuals. Screening is an ineffective activity if there is no participation by clients. Newborn (and homozygote) screening, on the basis of an experience involving 35 million infants, is usually considered as a 'successful' enterprise. But adult screening, usually for heterozygosity, is quantitatively a much more important activity in its execution, judging from current experience. Comprehension of risk and perceived importance of biological individuality by potential participants and advocates are part of the problem. A major revision in the education of medical personnel and citizens is indicated if medical genetics is to achieve its goals.

  14. Hatefulle ytringer. Delrapport 2: Forskning på hat og diskriminering

    OpenAIRE

    Eggebø, Helga; Stubberud, Elisabeth

    2016-01-01

    De siste årene har hatefulle ytringer blitt aktualisert som et viktig demokratisk spørsmål på den offentlige og politiske dagsordenen. Likevel finnes det foreløpig lite forskningsbasert kunnskap om hatefulle ytringer i norsk sammenheng. Denne rapporten har som formål å samle, oppsummere og vurdere forskning som belyser sammenhengen mellom hatefulle ytringer og diskriminering, mobbing og vold på den ene siden, og forskning om konsekvenser for samfunnet og for de gruppene som er utsatt på den a...

  15. Basic Business and Economics: Did You Throw Your Hat in the Arena?

    Science.gov (United States)

    Scriven, Jolene D.

    1977-01-01

    The author suggests that teachers of basic business and economics need to be involved in introducing current social and political issues in the classroom. If teachers encourage students to critically examine issues it should improve students' decision making skills and make classes more exciting and challenging. (HD)

  16. hat is the Relationship between Entrepreneurship and Unemployment in Visegrad Countries?

    Directory of Open Access Journals (Sweden)

    Ondrej Dvoulety

    2017-06-01

    Full Text Available The presented study aims to quantify the determinants of entrepreneurship in the four countries of the Visegrad (V4 group (the Czech Republic, Hungary, Poland and Slovakia with a particular focus on the relationship between entrepreneurship and unemployment. The purpose of the research was to analyze whether, during the periods of higher unemployment rate, individuals more likely engage into entrepreneurial activity. Data were collected from the national statistical offices of the Visegrad countries, World Bank, Eurostat and Heritage Foundation. The collected sample covered years 1998-2015. To achieve the main objective of the article, regression models with the dependent variable, the rate of registered businesses per economically active inhabitant, were quantified. Estimated regressions proved a positive relationship between entrepreneurship and unemployment. A higher unemployment rate was associated with the increase in overall entrepreneurial activity. Estimated models further confirmed the negative influence of the administrative barriers on the overall entrepreneurial activity. Several policy and research implications are discussed in the study.

  17. Indigenous Knowledge in the Life Sciences Classroom: Put on Your de Bono Hats!

    Science.gov (United States)

    de Beer, Josef; Whitlock, Elrina

    2009-01-01

    The whole world was united in its condemnation of the pre-1994 apartheid regime in South Africa. Apartheid meant that many South Africans were robbed of their democratic voices and cultural identities. In this article, the authors pose the question: Are you guilty of "knowledge apartheid" in your biology classroom? Does every student have a voice…

  18. The problem of low variance voxels in statistical parametric mapping; a new hat avoids a 'haircut'.

    Science.gov (United States)

    Ridgway, Gerard R; Litvak, Vladimir; Flandin, Guillaume; Friston, Karl J; Penny, Will D

    2012-02-01

    Statistical parametric mapping (SPM) locates significant clusters based on a ratio of signal to noise (a 'contrast' of the parameters divided by its standard error) meaning that very low noise regions, for example outside the brain, can attain artefactually high statistical values. Similarly, the commonly applied preprocessing step of Gaussian spatial smoothing can shift the peak statistical significance away from the peak of the contrast and towards regions of lower variance. These problems have previously been identified in positron emission tomography (PET) (Reimold et al., 2006) and voxel-based morphometry (VBM) (Acosta-Cabronero et al., 2008), but can also appear in functional magnetic resonance imaging (fMRI) studies. Additionally, for source-reconstructed magneto- and electro-encephalography (M/EEG), the problems are particularly severe because sparsity-favouring priors constrain meaningfully large signal and variance to a small set of compactly supported regions within the brain. (Acosta-Cabronero et al., 2008) suggested adding noise to background voxels (the 'haircut'), effectively increasing their noise variance, but at the cost of contaminating neighbouring regions with the added noise once smoothed. Following theory and simulations, we propose to modify--directly and solely--the noise variance estimate, and investigate this solution on real imaging data from a range of modalities. Copyright © 2011 Elsevier Inc. All rights reserved.

  19. „Strenger Geschmack hat bei uns keine Freunde”. Griechenland in der deutschen Werbung

    OpenAIRE

    Reimann, Sandra

    2016-01-01

    Den im Band präsentierten Beiträgen liegt sowohl theoretisch als auch empirisch eine medienlinguistische Perspektive in der Betrachtung gegenwärtiger gesellschaftspolitischer Ereignisse in Deutschland und Polen, die in letzter Zeit viele kontroverse Debatten hervorgerufen haben, zugrunde. Die gezeigten unterschiedlichen Möglichkeiten der Vernetzung linguistischer und medienorientierter Forschungen resultieren deshalb aus der Überzeugung, dass die Medien die Welt der Politik auf ihre Art inter...

  20. The Epidemiology of Childhood Asthma in Red Deer and Medicine Hat, Alberta

    Directory of Open Access Journals (Sweden)

    Patrick A Hessel

    2001-01-01

    Full Text Available OBJECTIVES: To document the prevalence of asthma among school-aged children in two Alberta communities, to understand host and indoor environmental factors associated with asthma, and to compare these factors between the two communities.

  1. Decommissioning. Success with preparation; Mit kompetenten Mitarbeitern gelingt der Rueckbau. Erfolg hat, wer darauf vorbereitet ist

    Energy Technology Data Exchange (ETDEWEB)

    Klasen, Joerg [ENBW Kernkraft GmbH, Neckarwestheim (Germany); Schulz, Rolf [Rolf Schulz HR Consultants AG, Baden-Baden (Germany); Wilhelm, Oliver

    2017-02-15

    The decommissioning of a nuclear power plant poses a significant challenge for the operating company. The business model is turned upside down and a working culture developed for power operation has to be adapted while necessary know- how for the upcoming tasks has to be built up. The trauma for the employees induced by the final plant shut-down has to be considered and respected. The change of working culture in the enterprise has to be managed and the organization has to be prepared for the future. Here the methods of Change-Management offer a systematic and effective approach. Confidence in the employee's competencies is one of the key success factors for the change into the future.

  2. Measurement of the diffractive structure function in deep inelastic scattering hat HERA

    International Nuclear Information System (INIS)

    Derrick, M.; Krakauer, D.; Magill, S.

    1995-05-01

    This paper presents an analysis of the inclusive properties of diffractive deep inelastic scattering events produced in ep interactions at HERA. The events are characterised by a rapidity gap between the outgoing proton system and the remaining hadronic system. Inclusive distributions are presented and compared with Monte Carlo models for diffractive processes. The data are consistent with models where the pomeron structure function has a hard and a soft contribution. The diffractive structure function is measured as a function of x IP , the momentum fraction lost by the proton, of β, the momentum fraction of the struck quark with respect to x IP , and of Q 2 . The x IP dependence is consistent with the form (1/x IP ) a where a=1.30-±0.80(stat) -0.14 +0.08 (sys) in all bins of βand Q 2 . In the measured Q 2 range, the diffractive structure function approximately scales with Q 2 at fixed β. In an Ingelman-Schlein type model, where commonly used pomeron flux factor normalisations are assumed, it is found that the quarks within the pomeron do not saturate the momentum sum rule. (orig.)

  3. BRD4 Regulates Transcription via Intrinsic HAT Activity | Center for Cancer Research

    Science.gov (United States)

    In order to express a gene, its DNA must be accessible to the transcription machinery. This requires chromatin de-compaction, which depends on the addition of acetyl groups to lysine residues on histones, thereby weakening interactions between histones and DNA and between adjacent nucleosomes.

  4. Commodity Cluster Computing for Remote Sensing Applications using Red Hat LINUX

    Science.gov (United States)

    Dorband, John

    2003-01-01

    Since 1994, we have been doing research at Goddard Space Flight Center on implementing a wide variety of applications on commodity based computing clusters. This talk is about these clusters and haw they are used on these applications including ones for remote sensing.

  5. Am I Wearing the Right Hat? Navigating Professional Relationships between Parent-Teachers and Their Colleagues

    Science.gov (United States)

    Lipsky, Eliana; Friedman, Ilana Dvorin; Harkema, Rebecca

    2017-01-01

    Utilizing organizational role theory and cognitive role theory as a theoretical framework, this phenomenological study examined the experience of parent-teachers and colleague-teachers in small educational settings and their perceptions of these dynamic relationships and potential areas of conflict. Findings highlighted perceived strengths, yet…

  6. Aging Trajectories in Different Body Systems Share Common Environmental Etiology : The Healthy Aging Twin Study (HATS)

    NARCIS (Netherlands)

    Moayyeri, Alireza; Hart, Deborah J.; Snieder, Harold; Hammond, Christopher J.; Spector, Timothy D.; Steves, Claire J.

    Little is known about the extent to which aging trajectories of different body systems share common sources of variance. We here present a large twin study investigating the trajectories of change in five systems: cardiovascular, respiratory, skeletal, morphometric, and metabolic. Longitudinal

  7. White hats or Don Quixotes? Human rights vigilantes in the global economy

    OpenAIRE

    Kimberly Ann Elliot; Richard B. Freeman

    2004-01-01

    With the continuing expansion of global economic integration, labor standards in developing countries have become a hot button issue. One result has been a proliferation of efforts to use the market to put pressure directly on multinational corporations to improve wages and working conditions in their overseas operations and to insist that their suppliers do so as well. This paper analyzes the dynamics of these efforts in terms of a 'market for standards' in which consumers, stimulated by hum...

  8. Shear dominated failure in the 'hat' specimen from the 2013 Sandia Fracture Challenge.

    Energy Technology Data Exchange (ETDEWEB)

    Corona, Edmundo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-11-01

    The objective of this memo is to present a brief report of the progress achieved during FY2016 on the investigation of ductile failure in the 2013 Sandia Fracture Challenge specimen. It is a follow-up to the results of an experimental investigation presented in [1]. The experi- mental investigation was conducted with both the original steel A286 material used in the fracture challenge as well as with Al 7075-T651. The new results include further microscopy work for the steel A286 specimens, failure criterion veri cation for both materials and the implementation of a nite element model containing `material imperfections' to simulate the limit load in the response of the steel A286 specimens. Funding used to conduct the work presented here was provided by the ASC V&V program on validation of shear failure (Benjamin Reedlunn, PI) and from Sandia's LDRD program. This memo assumes that the reader is familiar with the material in [1].

  9. Shear dominated failure in the 'hat' specimen from the 2013 Sandia Fracture Challenge.

    Energy Technology Data Exchange (ETDEWEB)

    Corona, Edmundo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-11-01

    The objective of this memo is to present a brief report of the progress achieved during FY2016 on the investigation of ductile failure in the 2013 Sandia Fracture Challenge specimen. The experimental investigation was conducted with both the original steel A286 material used in the fracture challenge as well as with Al 7075-T651. The new results include further microscopy work for the steel A286 specimens, failure criterion verification for both materials and the implementation of a finite element model containing `material imperfections' to simulate the limit load in the response of the steel A286 specimens. Funding used to conduct the work presented here was provided by the ASC V&V program on validation of shear failure (Benjamin Reedlunn, PI) and from Sandia's LDRD program.

  10. Construction legislation and energy efficiency. A discussion on the covered open spaces for ventilation adopted by the Rio de Janeiro city building code, Brazil; Legislacao edilicia e eficiencia energetica. Uma discussao sobre os vaos de ventilacao adotados pelo codigo de obras do Rio de Janeiro

    Energy Technology Data Exchange (ETDEWEB)

    Pimenta, Gustavo Carvalho; Barroso-Krause, Claudia [Universidade Federal, Rio de Janeiro, RJ (Brazil). Faculdade de Arquitetura e Urbanismo. Programa de Pos-graduacao em Arquitetura]. E-mails: gparj@terra.com.br; bkrause@ufrj.br

    2002-07-01

    This paper analyses, under the energetic efficiency viewpoint, the critical points of the Rio de Janeiro city construction legislation, by the time that decrees the directives for covered open spaces for ventilation in multi-familiar buildings. The paper also demonstrates where and how the building code influences the architectonic project to induce energy consumption not contributing for an efficient architecture.

  11. Demokraatia on vastuolus loodusega / Leszek Kolakowski ; tõlk. Hendrik Lindepuu

    Index Scriptorium Estoniae

    Kolakowski, Leszek

    2007-01-01

    Autor avaldab arvamust, et demokraatia ohustab rahvust ja rahvus ohustab demokraatiat. Tuleb analüüsida rahvuslikke kirgi ning vajaduse korral peavad demokraatlikud institutsioonid neid kirgi vaos hoidma

  12. Vanillyl-alcohol oxidase, a tasteful biocatalyst

    NARCIS (Netherlands)

    Heuvel, van den R.H.H.; Fraaije, M.W.; Mattevi, A.; Laane, C.; Berkel, van W.J.H.

    2001-01-01

    The covalent flavoenzyme vanillyl-alcohol oxidase (VAO) is a versatile biocatalyst. It converts a wide range of phenolic compounds by catalysing oxidation, deamination, demethylation, dehydrogenation and hydroxylation reactions. The production of natural vanillin, 4-hydroxybenzaldehyde, coniferyl

  13. The development of a practical tool for risk assessment of manual work – the HAT-tool

    NARCIS (Netherlands)

    Kraker, H. de; Douwes, M.

    2008-01-01

    For the Dutch Ministry of Social Affairs and Employment we developed a tool to assess the risks of developing complaints of the arm, neck or shoulders during manual work. The tool was developed for every type of organization and is easy to use, does not require measurements other than time and can

  14. Evaluation of Contact Heat Transfer Coefficient and Phase Transformation during Hot Stamping of a Hat-Type Part

    Science.gov (United States)

    Kim, Heung-Kyu; Lee, Seong Hyeon; Choi, Hyunjoo

    2015-01-01

    Using an inverse analysis technique, the heat transfer coefficient on the die-workpiece contact surface of a hot stamping process was evaluated as a power law function of contact pressure. This evaluation was to determine whether the heat transfer coefficient on the contact surface could be used for finite element analysis of the entire hot stamping process. By comparing results of the finite element analysis and experimental measurements of the phase transformation, an evaluation was performed to determine whether the obtained heat transfer coefficient function could provide reasonable finite element prediction for workpiece properties affected by the hot stamping process. PMID:28788046

  15. Schreiben hat auch eine Stimme. Eine explorative Untersuchung über die Beziehung zwischen lautem Sprechen und Schreiben.

    OpenAIRE

    Lohmeier-Weidner, Yvonne (B. A.)

    2017-01-01

    Die Aufgabe in dieser Arbeit ist die Untersuchung der Beziehung zwischen lautem Sprechen und Schreiben im Schreibprozess. Grundlage ist die Annahme, dass beides zusammengehört und das Verbalisieren von Gedanken zum Schreiben, ob im Dialog oder im Selbstgespräch, selbiges positiv unterstützt. Dazu werden drei Studentinnen der Universität Paderborn, die an einem Abschlussarbeitenworkshop des Kompetenzzentrums Schreiben teilnahmen, durch ein fokussiertes Interview befragt. Diese Interviews werde...

  16. Purple Boas, Lesbian Affection, and John Deere Hats: Teacher Educators' Role in Addressing Homophobia in Secondary Schools

    Science.gov (United States)

    Jones, Joseph R.

    2014-01-01

    This article examines how one group of teachers discussed their perceptions of homophobia in their schools. A qualitative study was conducted that utilized the following: individual and group interviews, participant reflective journals, professional development sessions, and a research journal. The study illuminated how the role of hegemonic…

  17. Electron optical study of the Venus Express ASPERA-4 Electron Spectrometer (ELS) top-hat electrostatic analyser

    International Nuclear Information System (INIS)

    Collinson, Glyn A; Kataria, D O; Coates, Andrew J; Tsang, Sharon M E; Arridge, Christopher S; Lewis, Gethyn R; Frahm, Rudy A; Winningham, J David; Barabash, Stas

    2009-01-01

    The performance of the Venus Express (VEX) ASPERA-4 Electron Spectrometer (ELS) is different from the nominal response shown by the ASPERA-3 ELS aboard Mars Express due to machining tolerance. Up to now, the precise mechanism for this was unknown and, therefore, the results of the experimental calibration could not be supported with a theoretical understanding of the fundamental instrument science behind the device. In this study, we show that the difference is due to a misalignment of the inner hemisphere and a widening of the entrance aperture of the instrument. The response of the VEX ELS can be approximated by a combination of a vertical offset of the inner hemisphere of ≈0.6 mm and a lateral offset of less than 0.125 mm, combined with an aperture that is ≈0.54 mm wider than nominal. The resulting K-factor, geometric factor, energy resolution and peak elevation are in good agreement with those observed experimentally. Therefore, we now have a good agreement between both laboratory calibration data and computer simulation, giving a firm foundation for future scientific data analysis

  18. Square-Toed Boots and Felt Hats: Irish Revolutionaries and the Invasion of Canada (1848-1871

    Directory of Open Access Journals (Sweden)

    Marta Ramón-García

    2010-03-01

    Full Text Available The Fenian movement was born in 1858 as an alliance between the Irish Republican Brotherhood, a revolutionary secret society, and the Fenian Brotherhood, an Irish-American organisation intended to supply this society with funds and trained officers. This was not the first time that Irish nationalists on both sides of the Atlantic had tried to cooperate, but it was the first time that there was a steady arrangement in place. The Fenian partnership was extremely successful on the surface, but it was undermined by fundamental differences in customs, political attitudes and ultimate goals between Irish and American Fenians. The clearest evidence of these differences was afforded by the Fenian Brotherhood’s successive attempts to invade Canada between 1866 and 1871. As military episodes the Canadian raids were negligible; as Irish revolutionary attempts they seem absurd. However, they were a perfectly coherent manifestation of the Irish-American “hyphenated identity”. The present article traces the parallel evolution of the Irish Republican Brotherhood and the Fenian Brotherhood up to 1866, and reconstructs the cultural and political reasons for the revival of the Canadian scheme, the ensuing split in the Fenian Brotherhood, and the final collapse of the Fenian alliance.

  19. Selective Hydrogen Atom Abstraction through Induced Bond Polarization: Direct α-Arylation of Alcohols through Photoredox, HAT, and Nickel Catalysis.

    Science.gov (United States)

    Twilton, Jack; Christensen, Melodie; DiRocco, Daniel A; Ruck, Rebecca T; Davies, Ian W; MacMillan, David W C

    2018-05-04

    The combination of nickel metallaphotoredox catalysis, hydrogen atom transfer catalysis, and a Lewis acid activation mode, has led to the development of an arylation method for the selective functionalization of alcohol α-hydroxy C-H bonds. This approach employs zinc-mediated alcohol deprotonation to activate α-hydroxy C-H bonds while simultaneously suppressing C-O bond formation by inhibiting the formation of nickel alkoxide species. The use of Zn-based Lewis acids also deactivates other hydridic bonds such as α-amino and α-oxy C-H bonds. This approach facilitates rapid access to benzylic alcohols, an important motif in drug discovery. A 3-step synthesis of the drug Prozac exemplifies the utility of this new method. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. An Algorithm Computing the Local $b$ Function by an Approximate Division Algorithm in $\\hat{\\mathcal{D}}$

    OpenAIRE

    Nakayama, Hiromasa

    2006-01-01

    We give an algorithm to compute the local $b$ function. In this algorithm, we use the Mora division algorithm in the ring of differential operators and an approximate division algorithm in the ring of differential operators with power series coefficient.

  1. Convolutional Neural Networks with Batch Normalization for Classifying Hi-hat, Snare, and Bass Percussion Sound Samples

    DEFF Research Database (Denmark)

    Gajhede, Nicolai; Beck, Oliver; Purwins, Hendrik

    2016-01-01

    After having revolutionized image and speech processing, convolu- tional neural networks (CNN) are now starting to become more and more successful in music information retrieval as well. We compare four CNN types for classifying a dataset of more than 3000 acoustic and synthesized samples...

  2. Engineering Encounters: The Cat in the Hat Builds Satellites. A Unit Promoting Scientific Literacy and the Engineering Design Process

    Science.gov (United States)

    Rehmat, Abeera P.; Owens, Marissa C.

    2016-01-01

    This column presents ideas and techniques to enhance your science teaching. This month's issue shares information about a unit promoting scientific literacy and the engineering design process. The integration of engineering with scientific practices in K-12 education can promote creativity, hands-on learning, and an improvement in students'…

  3. DSM-IV und DSM-5: Was hat sich tatsächlich verändert?

    OpenAIRE

    Ehret, Anna M.; Berking, Matthias

    2013-01-01

    Im Mai 2013 ist die fünfte Auflage des Diagnostischen und Statistischen Manuals Psychischer Störungen (DSM-5) der American Psychiatric Association erschienen. Um die Vor- und Nachteile des DSM-5 beurteilen und gegebenenfalls in Forschung und Praxis angemessen berücksichtigen zu können, sollten Wissenschaftler und Praktiker gleichermaßen über die Änderungen gegenüber dem DSM-IV informiert sein. In diesem Beitrag werden die wesentlichen Unterschiede zwischen dem DSM-IV und DSM-5 beschrieben. Ze...

  4. Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA HAT complexes

    Directory of Open Access Journals (Sweden)

    Lee Kenneth K

    2009-02-01

    Full Text Available Abstract Spinocerebellar ataxia (SCA is a physically devastating, genetically inherited disorder characterized by abnormal brain function that results in the progressive loss of the ability to coordinate movements. There are many types of SCAs as there are various gene mutations that can cause this disease. SCA types 1–3, 6–10, 12, and 17 result from a trinucleotide repeat expansion in the DNA-coding sequence. Intriguingly, recent work has demonstrated that increased trinucleotde expansions in the SCA7 gene result in defect in the function of the SAGA histone acetyltransferase complex. The SCA7 gene encodes a subunit of the SAGA complex. This subunit is conserved in yeast as the SGF73 gene. We demonstrate that Sgf73 is required to recruit the histone deubiquitination module into both SAGA and the related SliK(SALSA complex, and to maintain levels of histone ubiquitination, which is necessary for regulation of transcription at a number of genes.

  5. In vitro antioxidant capacity of tea of Echinodorus grandiforus, “leather hat,” in Wistar rat liver

    Directory of Open Access Journals (Sweden)

    RAFAELA F. LUNARDI

    2014-09-01

    Full Text Available Oxidative stress has been considered as one of the factors responsible for hepatic diseases, which sometimes require new ways of treatment. The present study aimed to evaluate the in vitro antioxidant capacity of the tea of Echinodorus grandiforus (“leather hat” plant in rat liver. Different preparations of tea were evaluated for phenolic composition, antioxidant activity by DPPH assay and ability to inhibit lipid peroxidation induced by copper sulfate. The antioxidant activity was assessed in liver tissue treated with sodium azide in the presence or absence of tea by assays for lipid peroxidation (TBARS, protein oxidation (carbonyl and the antioxidant enzymes catalase (CAT and superoxide dismutase (SOD. The results show that different preparations of tea are important sources of polyphenols and contain theobromine, catechin and vitexin. Furthermore, the results indicate that this tea exhibits an antioxidant activity by its ability to scavenge DPPH radical. Different preparations of tea prevented damage to lipids and proteins induced by sodium azide, as well as assisting in restoring CAT and SOD activities. Thus, it can be seen that E. grandiforus tea had antioxidant activity in serum and liver being able to prevent oxidative damages generated by sodium azide.

  6. Transcriptional Regulation by KLF6, A Novel Tumor Suppressor Gene in Prostate Cancer, Through Interaction with HATS and HDACS

    Science.gov (United States)

    2006-03-01

    Kimmelman1, Rui F Qiao1, Goutham Narla2, Asoka Banno1, Nelson Lau3, Paula D Bos1, Nelson Nuñez Rodriguez1, Bertrand C Liang4, Abhijit Guha3, John A...Shen Yao, 1 Asoka Banno, 3 Eldad Hod, 1 Helen L. Reeves, 1 Rui F. Qiao, 3 Olga Camacho-Vanegas, 2 Alice Levine, 1 Alexander Kirschenbaum, 1,4 Andrew M

  7. Effect of Web Assisted Education Supported by Six Thinking Hats on Students' Academic Achievement in Science and Technology Classes

    Science.gov (United States)

    Ercan, Orhan; Bilen, Kadir

    2014-01-01

    Advances in computer technologies and adoption of related methods and techniques in education have developed parallel to each other. This study focuses on the need to utilize more than one teaching method and technique in education rather than focusing on a single teaching method. By using the pre-test post-test and control group semi-experimental…

  8. A Xylenol Orange-Based Screening Assay for the Substrate Specificity of Flavin-Dependent para-Phenol Oxidases

    Directory of Open Access Journals (Sweden)

    Tom A. Ewing

    2018-01-01

    Full Text Available Vanillyl alcohol oxidase (VAO and eugenol oxidase (EUGO are flavin-dependent enzymes that catalyse the oxidation of para-substituted phenols. This makes them potentially interesting biocatalysts for the conversion of lignin-derived aromatic monomers to value-added compounds. To facilitate their biocatalytic exploitation, it is important to develop methods by which variants of the enzymes can be rapidly screened for increased activity towards substrates of interest. Here, we present the development of a screening assay for the substrate specificity of para-phenol oxidases based on the detection of hydrogen peroxide using the ferric-xylenol orange complex method. The assay was used to screen the activity of VAO and EUGO towards a set of twenty-four potential substrates. This led to the identification of 4-cyclopentylphenol as a new substrate of VAO and EUGO and 4-cyclohexylphenol as a new substrate of VAO. Screening of a small library of VAO and EUGO active-site variants for alterations in their substrate specificity led to the identification of a VAO variant (T457Q with increased activity towards vanillyl alcohol (4-hydroxy-3-methoxybenzyl alcohol and a EUGO variant (V436I with increased activity towards chavicol (4-allylphenol and 4-cyclopentylphenol. This assay provides a quick and efficient method to screen the substrate specificity of para-phenol oxidases, facilitating the enzyme engineering of known para-phenol oxidases and the evaluation of the substrate specificity of novel para-phenol oxidases.

  9. A Xylenol Orange-Based Screening Assay for the Substrate Specificity of Flavin-Dependent para-Phenol Oxidases.

    Science.gov (United States)

    Ewing, Tom A; van Noord, Aster; Paul, Caroline E; van Berkel, Willem J H

    2018-01-14

    Vanillyl alcohol oxidase (VAO) and eugenol oxidase (EUGO) are flavin-dependent enzymes that catalyse the oxidation of para -substituted phenols. This makes them potentially interesting biocatalysts for the conversion of lignin-derived aromatic monomers to value-added compounds. To facilitate their biocatalytic exploitation, it is important to develop methods by which variants of the enzymes can be rapidly screened for increased activity towards substrates of interest. Here, we present the development of a screening assay for the substrate specificity of para -phenol oxidases based on the detection of hydrogen peroxide using the ferric-xylenol orange complex method. The assay was used to screen the activity of VAO and EUGO towards a set of twenty-four potential substrates. This led to the identification of 4-cyclopentylphenol as a new substrate of VAO and EUGO and 4-cyclohexylphenol as a new substrate of VAO. Screening of a small library of VAO and EUGO active-site variants for alterations in their substrate specificity led to the identification of a VAO variant (T457Q) with increased activity towards vanillyl alcohol (4-hydroxy-3-methoxybenzyl alcohol) and a EUGO variant (V436I) with increased activity towards chavicol (4-allylphenol) and 4-cyclopentylphenol. This assay provides a quick and efficient method to screen the substrate specificity of para -phenol oxidases, facilitating the enzyme engineering of known para- phenol oxidases and the evaluation of the substrate specificity of novel para -phenol oxidases.

  10. JPRS Report East Asia Southeast Asia

    Science.gov (United States)

    1987-06-30

    uti - lization of natural resources." "The, Stale shall from lime.1.6 lime, review to upgrade pensions and other benefits due to retirees of both the...VIETNAM RATIONAL, INTENSIVE EXPORT OF PHARMACEUTICALS PROPOSED Hanoi NHAN DAN in Vietnamese 14 Apr 87 p 3 [Article by pharmacist Nguyen Duy Cuong

  11. The Role in the Virtual Astronomical Observatory in the Era of Massive Data Sets

    Science.gov (United States)

    Berriman, G. Bruce; Hanisch, Robert J.; Lazio, T. Joseph W.

    2012-01-01

    The Virtual Observatory (VO) is realizing global electronic integration of astronomy data. One of the long-term goals of the U.S. VO project, the Virtual Astronomical Observatory (VAO), is development of services and protocols that respond to the growing size and complexity of astronomy data sets. This paper describes how VAO staff are active in such development efforts, especially in innovative strategies and techniques that recognize the limited operating budgets likely available to astronomers even as demand increases. The project has a program of professional outreach whereby new services and protocols are evaluated.

  12. Power assistant systems as the ultimate goal. Exchanging meters is not enough; Energieassistenzsysteme als Zielsetzung. Wer nur an den Zaehleraustausch denkt, hat schon verloren

    Energy Technology Data Exchange (ETDEWEB)

    Hein, Franz [mpc Management Project Coaching, Esslingen (Germany)

    2009-12-14

    In the cost-profit calculation, the energy advantage of power assistant systems must be higher than their power consumption. It is inacceptable to regard only the views of individual market partners or only certain time periods during a system's life. Purely monetary considerations are off the mark because no amount of money can buy a new environment for mankind. The current one is the only one we have. (orig.)

  13. More than one rabbit out of the hat: Radiation, transgenic and symbiont-based approaches for sustainable management of mosquito and tsetse fly populations

    International Nuclear Information System (INIS)

    Bourtzis, K.; Lees, R.S.; Hendrichs, J.; Vreysen, M.J.B.

    2016-01-01

    Mosquitoes (Diptera: Culicidae) and tsetse flies (Diptera: Glossinidae) are bloodsucking vectors of human and animal pathogens. Mosquito-borne diseases (malaria, filariasis, dengue, chikungunya and Zika) cause severe mortality and morbidity annually, and tsetse fly-borne diseases (African trypanosomes causing sleeping sickness in humans and nagana in livestock) cost Sub-Saharan Africa an estimated US$ 4750 million annually. Current reliance on insecticides for vector control is unsustainable: due to increasing insecticide resistance and growing concerns about health and environmental impacts of chemical control there is a growing need for novel, effective and safe biologically- based methods that are more sustainable. The integration of the sterile insect technique has proven successful to manage crop pests and disease vectors, particularly tsetse flies, and is likely to prove effective against mosquito vectors, particularly once sexseparation methods are improved. Transgenic and symbiont-based approaches are in development, and more advanced in (particularly Aedes) mosquitoes than in tsetse flies; however, issues around stability, sustainability and biosecurity have to be addressed, especially when considering population replacement approaches. Regulatory issues and those relating to intellectual property and economic cost of application must also be overcome. Standardised methods to assess insect quality are required to compare and predict efficacy of the different approaches. Different combinations of these three approaches could be integrated to maximise their benefits, and all have the potential to be used in tsetse and mosquito area-wide integrated pest management programmes. (author)

  14. Die Einsetzung parlamentarischer Untersuchungsausschüsse im Deutschen Bundestag: welchen Einfluss hat die Auffälligkeit eines Themas? / Marco Radojevic

    Index Scriptorium Estoniae

    Radojevic, Marco

    2016-01-01

    Parlamendi uurimiskomisjonide osast parlamentaarses kontrollisüsteemis; avaliku arvamuse, meedia ja teema olulisuse seosest uurimiskomisjoni moodustamiseks Saksa parlamendi uurimiskomisjonide liikmete küsitluse põhjal

  15. “Wer jetzt kein Haus hat, baut sich keines mehr”. Notes on Bruce O’Neill’s "The Space of Boredom"

    Directory of Open Access Journals (Sweden)

    George Tudorie

    2017-12-01

    Full Text Available Bruce O’Neill describes homeless men and women in Bucharest who could not navigate the downward spiral which followed the meltdown of the state-run economy after 1989. Deprived of the culturally treasured anchors of work, home, and family, and unable to participate in anything recognizably meaningful, these individuals are forced into a position of malignant contemplation, even when busy surviving. It is an experience of paralyzed restlessness which resonates with the ruins they zigzag through. The Space of Boredom captures this landscape convincingly, and in elegant prose. The book moves effortlessly from the discussion of scholarly works in a number of fields, to observation of sometimes cinematic quality. It is well argued, abundantly researched, and clear about its theoretical assumptions. If some questions remain to be answered, at least to this reader, this may be an artifact of background. Assumptions, including important ones about the nature of affects, and about boredom itself, may not be shared. Some questions of this kind will be raised in the following.

  16. Mating and memory: an educational primer for use with "epigenetic control of learning and memory in Drosophila by Tip60 HAT action".

    Science.gov (United States)

    Schmidt, Rebecca L; Sheeley, Sara L

    2015-05-01

    An article by Xu et al. in the December 2014 issue of GENETICS can be used to illustrate epigenetic modification of gene expression, reverse genetic manipulation, genetic/epigenetic influence on behavioral studies, and studies using the Drosophila model organism applied to human disease. This Primer provides background information; technical explanations of genetic, biochemical, and behavioral approaches from the study; and an example of an approach for classroom use with discussion questions to aid in student comprehension of the research article. Copyright © 2015 by the Genetics Society of America.

  17. Pisanello’s hat. The costume and weapons depicted in Pisanello’s medal for John VIII Palaeologus. A discussion of the saber and related weapons

    Directory of Open Access Journals (Sweden)

    Alexander, David

    2004-12-01

    Full Text Available A group of six drawings by the Veronese artist Antonio Pisano depicted the Bizantine Emperor John VIII Paleologus wearing costumes and weapons according to islamic types. This paper studies these objects in relation to other contemporary islamic weapons.

    Un grupo de seis dibujos del artista veronés Antonio Pisano representa al emperador bizantino Juan VIII Paleólogo vestido y armado según modelos islámicos. Este trabajo estudia dichos objetos en relación a otras armas islámicas contemporáneas.

  18. More than one rabbit out of the hat: Radiation, transgenic and symbiont-based approaches for sustainable management of mosquito and tsetse fly populations.

    Science.gov (United States)

    Bourtzis, Kostas; Lees, Rosemary Susan; Hendrichs, Jorge; Vreysen, Marc J B

    2016-05-01

    Mosquitoes (Diptera: Culicidae) and tsetse flies (Diptera: Glossinidae) are bloodsucking vectors of human and animal pathogens. Mosquito-borne diseases (malaria, filariasis, dengue, zika, and chikungunya) cause severe mortality and morbidity annually, and tsetse fly-borne diseases (African trypanosomes causing sleeping sickness in humans and nagana in livestock) cost Sub-Saharan Africa an estimated US$ 4750 million annually. Current reliance on insecticides for vector control is unsustainable: due to increasing insecticide resistance and growing concerns about health and environmental impacts of chemical control there is a growing need for novel, effective and safe biologically-based methods that are more sustainable. The integration of the sterile insect technique has proven successful to manage crop pests and disease vectors, particularly tsetse flies, and is likely to prove effective against mosquito vectors, particularly once sex-separation methods are improved. Transgenic and symbiont-based approaches are in development, and more advanced in (particularly Aedes) mosquitoes than in tsetse flies; however, issues around stability, sustainability and biosecurity have to be addressed, especially when considering population replacement approaches. Regulatory issues and those relating to intellectual property and economic cost of application must also be overcome. Standardised methods to assess insect quality are required to compare and predict efficacy of the different approaches. Different combinations of these three approaches could be integrated to maximise their benefits, and all have the potential to be used in tsetse and mosquito area-wide integrated pest management programmes. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  19. PRIZREN UNION SOCIETY IN THE AGE OF NATIONALISM MİLLİYETÇİLİK ÇAĞINDA PRIZREN İTTİHAT CEMİYETİ

    Directory of Open Access Journals (Sweden)

    Yücel YİĞİT

    2009-12-01

    Full Text Available On XVIII and XIX Centuries, modernization and nationalism had started in spreading with acceleration and had caused holistic nature with the cracks and distinctions between the east-west, also this situation over time had become downright deep. The unrest that started in this century, continued until World War II. Founded after the 1878 Berlin Congress, Prizren Union Society had intended to establish an independent state by being feed up with nationalism, in Albanian geography. Prizren Union Society, by discarding itself from the first decision of the society foundation, had gained power after became the locomotive of nationalism among the Albanians. However, as it was known at the beginning Prizren Union Society was not in the mood of establishing a free state, also even they didn’t want to part from Ottoman Empire. Despite the uncertainty and incapability on society ideas, Prizren Union Society could achieve to start Albanian national awakening and further more, had prepared the ground for Albanian’s separation from Ottoman Empire as being a free state at 1913. During this period, Britain, Russia, Austria-Hungary and Italy, such a large states, had even opened consulates in Prizren to follow the events closely. XVIII. ve XIX. Yüzyıllarda başlayıp hız kazanan milliyetçilik ve modernleşme; doğu-batı arasında bütünsel nitelikte çatlamalara yol açmış, ayrımlar zamanla büsbütün derinleşmiştir. Bu yüzyıllarda başlayan huzursuzluk II. Dünya Savaşı’na kadar devam etmiştir. 1878 Berlin Kongresi sonrası kurulan Prizren İttihat Cemiyeti ise milliyetçilik damarından beslenerek Arnavut coğrafyasında müstakil bir devlet kurmaya niyetlendi. Cemiyet, ilk kuruluş amacından saparak Arnavut milliyetçiliğinin lokomotifi haline geldikten sonra Arnavutlar arasında güç kazanmıştır. Hâlbuki başlangıçta Cemiyet’in milliyetçi bir hareket noktasında yola çıkmadığı aksine Osmanlı Devleti’nden ayrılmak gibi bir niyetle kurulmadığı bilinmektedir. Fikir belirsizliği ve uyumsuzluğa rağmen cemiyet, Arnavut milli uyanışını başlatmış ve 1913 tarihinde Osmanlı Devleti’nden koparak müstakil bir devlet haline gelecek olan Arnavutluk Devleti’ne zemin hazırlamıştır. Bu dönemde İngiltere, Rusya, Avusturya-Macaristan ve İtalya gibi büyük devletler olayları yakından takip etmek için Prizren’de konsolosluklar bile açmışlardır.

  20. Hats off to CERN's Master of Apprenticeships ! Roland Gay of the HR Department (at right) recently received a special diploma from the Geneva Industrial Union (UIG).

    CERN Multimedia

    2004-01-01

    Presented by Carlo Lamprecht, Head of the Department of Economy, Employment and External Affairs of the State of Geneva, the diploma was awarded in recognition of the 199 CERN apprentices Roland has guided through the Certificat Fédéral de Capacité (CFC), an end-of-apprenticeship certificate awarded by the Cantonal authorities. Roland will be retiring in December 2004 after 37 years of service, 32 of which he spent in the role of apprenticeship supervisor.

  1. "Und immer hat's geklungen...". Zu Dämonie und Erlebniskrise in Brentanos "Lore Lay" und in der von Hoffmann und Kierkegaard gedeuteten Mozartschen Don-Juan-Figur

    DEFF Research Database (Denmark)

    Ekmann, Bjørn

    1995-01-01

    Clemens Brentano, fremmedgørelse, indlevelse, romantik, oplevelseskrise, Mozart, E.T.A. Hoffmann, Søren Kierkegaard, forførelsesmotiv......Clemens Brentano, fremmedgørelse, indlevelse, romantik, oplevelseskrise, Mozart, E.T.A. Hoffmann, Søren Kierkegaard, forførelsesmotiv...

  2. What are the consequences of the reactor accident in Fukushima for the evaluation of nuclear risk?; Welche Folgen hat der Kernkraftwerksunfall in Fukushima fuer die Bewertung von Kernenergierisiken?

    Energy Technology Data Exchange (ETDEWEB)

    Renn, Ortwin [Univ. Stuttgart (Germany). Inst. Sozialwissenshaften V; Gallego Carrera, Diana [Univ. Stuttgart (Germany). ZIRIUS Zentrum fuer Interdiszipliaere Risiko- und Innovationsforschung

    2015-06-01

    There are historical breaks in the relation of risk analysis, risk perception and regulation policy. The year 2011 with the reactor accident in the NPP Fukushima was such a break, especially in Germany. The nuclear phase-out was reduced to ten years the energy policy turnaround received a broad societal agreement. Nuclear facilities loose public acceptance, the risk perception has changed. The Japanese evaluation results on faulty and nontransparent behavior and the lack of governance of responsible persons and authorities including a poor accident management have further decreased the public confidence. A new concept of safety culture for all nuclear facilities including the radioactive waste management is required, the communication processes between plant operator, authorities, science and the public have to be intensified.

  3. Environmental science and pleasing architecture. Yale university's most energy-efficient building; Umweltwissenschaft mit Eleganz. Die Universitaet von Yale hat ihr bisher energieeffizientestes Gebaeude eingeweiht

    Energy Technology Data Exchange (ETDEWEB)

    Hirsch, Matthew; Wagner, Neelke

    2010-01-15

    The department of forestry and environmental science of Yale University has a new administrative building. The building has a 105 kW solar power system which supplies 25 percent of the required power. The system was installed on the roof in the conventional way but with an unusual assembly system that resulted in pleasing architecture. (orig.)

  4. Trouble in paradise. Did Chinese solar producer Jinko Solar pollute water with toxic effluents?; Aerger im Paradies. Hat der chinesische Solarkonzern Jinko Solar Giftstoffe ins Abwasser geleitet?

    Energy Technology Data Exchange (ETDEWEB)

    Siemer, Jochen

    2011-10-15

    When neighbours protested against toxic effluents emitted by a Chinese industrial plant, this received international attention, especially as the plant in question is producing solar cells for Jinko Solar at Haining. However, the real facts are impossible to obtain.

  5. Anaerobic Pseudomonas aeruginosa and other obligately anaerobic bacterial biofilms growing in the thick airway mucus of chronically infected cystic fibrosis patients: an emerging paradigm or "Old Hat"?

    Science.gov (United States)

    Su, Shengchang; Hassett, Daniel J

    2012-09-01

    The cystic fibrosis (CF) airway mucus is an ideal niche in which many bacteria can develop antibiotic- and phagocyte-resistance in unique structures known as "mode II biofilms" where bacteria are embedded within the mucus, yet unattached to airway epithelial cells. Pseudomonas aeruginosa is the dominant CF pathogen, yet herein the authors provide burgeoning evidence that obligate anaerobic bacteria (e.g., Prevotella) actually thrive within the CF mucus, a paradigmatic shift that chronic CF is an "aerobic" disease. Interestingly, CF organisms repress virulence factor production (e.g., P. aeruginosa) while others (e.g., S. aureus) increase them under anaerobic conditions. The authors shed additional light on (i) the anoxic nature of the CF airway mucus, (ii) the relative commonality of anaerobic bacteria isolated from CF sputum, (iii) virulence factor production and cross-talk between obligate anaerobes and P. aeruginosa relative to disease progression/remission, (iv) the role of mucoidy in CF, and (v) the role of nitrosative stress in activation of bacteriophage and pyocins within biofilms. The authors conclude with insight as to how we might treat some CF bacteria during mode II biofilm infections that utilizes a metabolite of bacterial anaerobic respiration and an aerobic oxidation product of airway-generated NO, acidified NO(2)(-).

  6. Calcium in pollen-pistil interaction in `Petunia hybrida Hat`. Pt. 3. Localization of Ca{sup 2+} ions and Ca{sup 2+}-ATPase in pollinated pistil

    Energy Technology Data Exchange (ETDEWEB)

    Bednarska, E.; Butowt, R. [Uniwersytet Mikolaja Kopernika, Torun (Poland)

    1995-12-31

    Studies were carried out of Ca{sup 2+} and Ca{sup 2+}-ATPase localization in pollinated (6 and 48 h after pollination) pistils of `Petunia hybrida`. The results were confronted with Ca{sup 2+} localization in mature pollen grain and in unpollinated pistil. It has been found that after pollination the number of Ca{sup 2+} sequestered in the stigmal exudate and in the sporoderm of the pollen grain gets lower. That phenomenon was associated with the appearance of a large number of Sb/Ca precipitates in the submembrane cytoplasm of the germinating pollen. In the vacuolized pollen grain, i.e. grown into a pollen tube, there were only a few precipitates. In the pollen tube, Ca{sup 2+} were found in the organelles of the tip cytoplasm and in the external pectin cell wall. Studies with the use of {sup 45}Ca{sup 2+} have revealed that the source of calcium ions incorporated into the pollen tube tip and its pectin wall is the transmitting tract of the style. In the transmitting tract overgrown with pollen tubes, Ca{sup 2+} were localized in the intercellular matrix and in the transmitting cell. Sb/Ca precipitates occurred in the nuclei, around the secretary vesicles and on the plasmalemma in the transverse walls region. Elevated Ca{sup 2+} level was found in degenerating cells (inhibited pollen tubes, transmitting cells, nucellar cells). The progressing degeneration process of the cells of the transmitting tract of the pollinated pistil was associated with a decrease in the activity of plasmalemma Ca{sup 2+}-ATPase. (author). 30 refs, 19 figs.

  7. Calcium in pollen-pistil interaction in 'Petunia hybrida Hat'. Pt. 3. Localization of Ca2+ ions and Ca2+-ATPase in pollinated pistil

    International Nuclear Information System (INIS)

    Bednarska, E.; Butowt, R.

    1995-01-01

    Studies were carried out of Ca 2+ and Ca 2+ -ATPase localization in pollinated (6 and 48 h after pollination) pistils of 'Petunia hybrida'. The results were confronted with Ca 2+ localization in mature pollen grain and in unpollinated pistil. It has been found that after pollination the number of Ca 2+ sequestered in the stigmal exudate and in the sporoderm of the pollen grain gets lower. That phenomenon was associated with the appearance of a large number of Sb/Ca precipitates in the submembrane cytoplasm of the germinating pollen. In the vacuolized pollen grain, i.e. grown into a pollen tube, there were only a few precipitates. In the pollen tube, Ca 2+ were found in the organelles of the tip cytoplasm and in the external pectin cell wall. Studies with the use of 45 Ca 2+ have revealed that the source of calcium ions incorporated into the pollen tube tip and its pectin wall is the transmitting tract of the style. In the transmitting tract overgrown with pollen tubes, Ca 2+ were localized in the intercellular matrix and in the transmitting cell. Sb/Ca precipitates occurred in the nuclei, around the secretary vesicles and on the plasmalemma in the transverse walls region. Elevated Ca 2+ level was found in degenerating cells (inhibited pollen tubes, transmitting cells, nucellar cells). The progressing degeneration process of the cells of the transmitting tract of the pollinated pistil was associated with a decrease in the activity of plasmalemma Ca 2+ -ATPase. (author). 30 refs, 19 figs

  8. Reduction of motor fuel consumption - Which recipes does the state have at its disposal?; Absenkung des Treibstoffverbrauchs: Welche Rezepte hat der Staat?

    Energy Technology Data Exchange (ETDEWEB)

    Volken, T.

    2008-07-01

    This presentation made at the Swiss 2008 research conference on traffic by Thomas Volken from the Energy Policy Section of the Swiss Federal Office of Energy SFOE takes a look at how motor-fuel consumption can be reduced. First of all, the present situation with regard to heating oil and motor fuels is examined and the gap between actual CO{sub 2} emissions from motor fuels and the target aimed for is discussed. Various legal and economical measures available are examined as are the promotion of technical innovation and motivational measures. The federal energy efficiency action plan and bonus/malus schemes are discussed and the environment label for cars is examined. Further, the situation in the European Union is discussed.

  9. The Spacecraft Earth has no emergency exit. Energy and politics in the anthropocene; Das Raumschiff Erde hat keinen Notausgang. Energie und Politik im Anthropozaen

    Energy Technology Data Exchange (ETDEWEB)

    Crutzen, Paul J.; Mastrandrea, Michael D.; Schneider, Stephen H.; Davis, Mike; Sloterdijk, Peter

    2011-07-01

    The accident at the nuclear power plant in Fukushima reminds us that the handling of the people with their planet looks like a disaster movie, where rival mafia groups deliver a gun battle with large caliber weapons on board of an aircraft at an altitude of 12,000 meters. In this book contributions of climate scientists, sociologists and philosophers are compared. Michael Mastrandrea and Stephen Schneider from the Intergovernmental Panel on Climate Change (IPCC) provide a compact overview of their work and their recommendations for policy makers. Mike Davis talks about the criticism of the IPCC reports and explains why ecologic and truly democratic cities can offer a way out of the climate crisis. Peter Sloterdijk thinks about Buckminster Fuller's metaphor of the 'spaceship earth' and the end of the 'kinetic expressionism.

  10. Female orgasm(s): one, two, several.

    Science.gov (United States)

    Jannini, Emmanuele A; Rubio-Casillas, Alberto; Whipple, Beverly; Buisson, Odile; Komisaruk, Barry R; Brody, Stuart

    2012-04-01

    There is general agreement that it is possible to have an orgasm thru the direct simulation of the external clitoris. In contrast, the possibility of achieving climax during penetration has been controversial. Six scientists with different experimental evidence debate the existence of the vaginally activated orgasm (VAO). To give reader of The Journal of Sexual Medicine sufficient data to form her/his own opinion on an important topic of female sexuality. Expert #1, the Controversy's section Editor, together with Expert #2, reviewed data from the literature demonstrating the anatomical possibility for the VAO. Expert #3 presents validating women's reports of pleasurable sexual responses and adaptive significance of the VAO. Echographic dynamic evidence induced Expert # 4 to describe one single orgasm, obtained from stimulation of either the external or internal clitoris, during penetration. Expert #5 reviewed his elegant experiments showing the uniquely different sensory responses to clitoral, vaginal, and cervical stimulation. Finally, the last Expert presented findings on the psychological scenario behind VAO. The assumption that women may experience only the clitoral, external orgasm is not based on the best available scientific evidence. © 2012 International Society for Sexual Medicine.

  11. Biodegradation of hydrocarbons exploiting spent substrate from ...

    African Journals Online (AJOL)

    SAM

    2014-08-13

    Aug 13, 2014 ... Key words: Bioremediation, diesel, laccase, veratryl alcohol oxidase, Pleurotus ostreatus. ... Abbreviations: Lac, Laccases; MnP, Manganese peroxidases; VP, versatile peroxidases; VAO, veratryl alcohol oxidases; SMS, ..... Hacia un desarrollo sostenible del sistema de producción-consumo de los hongos ...

  12. Vanillyl alcohol oxidases produced in Komagataella phaffii contain a highly stable non-covalently bound anionic FAD semiquinone

    NARCIS (Netherlands)

    Gygli, G.A.; Berkel, van W.J.H.

    2017-01-01

    Vanillyl alcohol oxidase (VAO) from Penicillium simplicissimum is a covalent flavoprotein that has emerged as a promising biocatalyst for the production of aromatic fine chemicals such as vanillin, coniferyl alcohol and enantiopure 1-(4’-hydroxyphenyl) alcohols. The largescale production of this

  13. Effect of argan and olive oil consumption on the hormonal profile of androgens among healthy adult Moroccan men.

    Science.gov (United States)

    Derouiche, Abdelfettah; Jafri, Ali; Driouch, Issam; El Khasmi, Mohammed; Adlouni, Ahmed; Benajiba, Nada; Bamou, Youssef; Saile, Rachid; Benouhoud, Mohammed

    2013-01-01

    This study aimed to assess the effect of virgin argan oil (VAO) and extra virgin olive oil (EVO) on the hormonal profile of androgens and anthropometric parameters among healthy adult Moroccan men during a controlled nutritional intervention. The study was carried out on 60 young and healthy male volunteers aged between 23 and 40 years old. During a stabilization period of 2 weeks they consumed butter. The group was then randomized into two categories, the first one consuming VAO and the second EVO for 3 weeks. Testosterone (T), luteinizing hormone (LH) and dehydroepiandrosterone (DHEAS) serum concentrations were measured at the beginning of the study and at the end of each period. The Mann-Whitney test was used to compare the two groups (VAO and EVO) during each step of the study. Differences in androgens and anthropometric parameters between the baseline and after 3 weeks of the diet in the VAO and EVO groups were analyzed using the Wilcoxon test. T and LH serum concentrations significantly increased after the intervention period. T levels increased by 19.9% and 17.4% (p consumption of AVO and EVO might be the origin of a positive action on the androgen hormonal profile of men.

  14. Direction of the reactivity of vanillyl-alcohol oxidase with 4-alkylphenols

    NARCIS (Netherlands)

    van den Heuvel, RHH; Fraaije, MW; van Berkel, WJH; Heuvel, Robert H.H. van den; Berkel, Willem J.H. van

    2000-01-01

    The covalent flavoprotein vanillyl-alcohol oxidase (VAO) predominantly converts short-chain 4-alkylphenols, like 4-ethylphenol, to (R)-1-(4'-hydroxyphenyl)alcohols and medium-chain 4-alkylphenols, like 4-butylphenol, to 1-(4'-hydroxyphenyl)alkenes. Crystallographic studies have indicated that the

  15. Use of Self-Expanding Stents for the Treatment of Vertebral Artery Ostial Stenosis: a Single Center Experience

    International Nuclear Information System (INIS)

    Chung, Sun Young; Lee, Deok Hee; Choi, Jin Woo; Choi, Byung Se; In, Hyun Sin; Kim, Sun Mi; Choi, Choong Gon; Kim, Sang Joon; Suh, Dae Chul

    2010-01-01

    To evaluate our early experience using self-expanding stents to treat atherosclerotic vertebral artery ostial stenosis (VAOS), with respect to technical feasibility and clinical and imaging follow-up results. A total of 20 lesions in 20 patients underwent stenting of the VAOS using a self-expanding stent (Precise RX; Cordis Neurovascular, Miami Lakes, FL). Two patients were asymptomatic. We analyzed the technical success rate, causes of technical failure, occurrence of any vascular or neurological event, and the occurrence of any neurological abnormality or in-stent restenosis (ISR) seen on follow-up. The imaging follow-up was performed with Doppler ultrasound (DUS) as a primary screening modality. One instance of technical failure was caused by failure of the guidewire passage. The stent diameter was 5 mm, and post-stenting balloon dilatations were necessary in all cases. Stent misplacement requiring placement of an additional stent occurred in four cases. Following a 14.8 month average clinical follow-up time, two patients showed anterior circulation ischemia, which was not attributed to the VAOS we treated. Following a 13.7 month average DUS follow-up, five patients showed a mild degree of diffuse or focal intimal thickening in the stent lumen; however, none of the stenosis showed luminal loss of more than 50% and no stent fracture was noted. The use of self-expanding stents for treating VAOS was technically feasible and helped to improve artery patency during our limited follow-up interval

  16. Edebî Tür Olarak Mektup, Hatıra ve Günlüklere Yansıyanlar: Çanakkale’de Savaşan Askerlerin Mektup Hatıra ve Günlüklerinde Yer Alan Motivasyon Unsurları

    Directory of Open Access Journals (Sweden)

    Korhan Altunyay

    2014-01-01

    Full Text Available Science of literature uses different genres such as diaries, memories and letters as both literary genres and a resource of research. These genres/resources are also used for psychological researches. Letters, memories and diaries are used to analyze the writer’s subconscious and to understand from which angle the writer looks at the problems, events and life. memories and diaries. In this paper, we will use letters, memories and diaries of our soldiers in the Battle of Canakkale in order to reveal the motivation behind their behavior.

  17. Southeast Asia Report.

    Science.gov (United States)

    1985-09-12

    Minister of Justice Comments on New Criminal Code (Phan Hien; NHAN DAN, 2, 3 Jul 85) m Army Paper Discusses Induction Task of Localities...administrative code , the local executives are responsible for the maintenance of peace and order in their respective jurisdiction. It is necessary...Albay 9 days ago. He died clutching the Philipping national flag as a touching symbol of what he fought and died for. 58 But M/Sgt Isaias Silvestre

  18. Poisson sampling - The adjusted and unadjusted estimator revisited

    Science.gov (United States)

    Michael S. Williams; Hans T. Schreuder; Gerardo H. Terrazas

    1998-01-01

    The prevailing assumption, that for Poisson sampling the adjusted estimator "Y-hat a" is always substantially more efficient than the unadjusted estimator "Y-hat u" , is shown to be incorrect. Some well known theoretical results are applicable since "Y-hat a" is a ratio-of-means estimator and "Y-hat u" a simple unbiased estimator...

  19. A szélsőséges időjárási jelenségek hatásai (Effects of the Extreme Weather Events

    Directory of Open Access Journals (Sweden)

    Tamás Molnár

    2015-04-01

    Full Text Available Economist Sir Nicholas Stern warned that the global warming could cause major blow to the world economy than the two world wars and the crisis in the 1930s. But where are we in this process now and what can be expected in the near future and what opportunities we are to curb the negative effects and to slow down the global warming. The world’s population is more than 7 billion people now and we will live more than 9 billion on the planet in 2050 according to the conservative estimation because daily the number of inhabitants increases by approximitaly a quarter of a million people (National Rural Strategy, 2020. The water and ecosystem resources are diminishing due to overuse and the values of ecological footprint are very high especially in the developed countries. The increase of extreme weather events and its effects associated with the global warming have also growing impact on agricultural production. This phenomenon is important because to solve the famine and the water shortage will be much bigger problem due to climate change than today. The VAHAVA reports (change-impact-response draw also attention to the issue which is also important for experts of climate change: Is it clearly climate change and if so than what the role of the human activity in it is? It seems clear that the assumption is almost poetic as the earth sends clear messages: the concentration of greenhouse gases increased suddenly in the atmosphere (carbon-dioxide, methan, nitrous oxide, etc, the average temperature continues to rise (increasing number of hot records, the sea temperature is also rising, the area of glaciers is shrinking dramatically and prolonged drought and flood waters in some places appear. The habitats of plans and animals, routes of bird migration change. The negative effects of extreme weather events thus represent a broad problem area. The effects can be devide into several groups. Some of them have impact already relatively short-term (for example affect of health of people another part of them, however, exerts a negative influence in an indirect way for a long period of time. According to our present knowledge these processes are irreversible. The 4th Water Report published by UNESCO is dealing with the one of the biggest problems which draws attention to hazards which are related water quality, groundwater, desertification, land degradation and drought (UNESCO, 2013. The report finds that the water problem occurs globally and it stresses the dangers of „isolated” thinking related to climate chnage. However, the isolated thinking appears not only within the geographical boundaries but it also can be observed in sectors together with the „isolated” solution search. Solution to the problems outlined as an innovation process have already begun in developed countries, however, the developing countries need serious help in that regard. The situation is further aggravated by perpetual competition for water between the ecosystem and socio-economic sectors.

  20. The countdown for the negotiations on the exit of Great Britain from the EU and Euratom has begun; Alea iacta est. Der Countdown fuer die Verhandlungen ueber den Ausstieg Grossbritanniens aus EU und EURATOM hat begonnen

    Energy Technology Data Exchange (ETDEWEB)

    Feldmann, Ulrike

    2017-07-15

    On 29 March 2017 the official letter from the United Kingdom to the President of the EU Council was presented to inform the European Council of its intention to withdraw from the European Union (EU). The period of 2 years in Article 50 of the EU Treaty provided for the exit negotiations has thus begun to run. In the letter to the President of the Council, the UK Government expressly declares its intention to withdraw from the EU and from the Euratom Treaty (EAV). Thus the controversy about the conjunction of the withdrawal from the EU and Euratom has become obsolete.

  1. Moorovo prokletí : na alternativní zdroje energie si počkáme, spoléhat na rychlý pokrok techniky je zrádné

    Czech Academy of Sciences Publication Activity Database

    Cílek, Václav

    2009-01-01

    Roč. 20, č. 3 (2009), s. 66-67 ISSN 0862-6545 Institutional research plan: CEZ:AV0Z30130516 Keywords : energy * energy sources * coal * petroleum * renewable resources Subject RIV: DB - Geology ; Mineralogy

  2. The dream has ended. The German solar industry has just completed a bad year - and has any good year ahead; Aus der Traum. Die deutsche Solarindustrie hat ein schlechtes Jahr hinter sich - und wohl kein gutes vor sich

    Energy Technology Data Exchange (ETDEWEB)

    Podewils, Christoph

    2013-01-15

    In the year 2012, the German solar industry lost one-third of the production level in comparison to the year 2011. Also the production capacities decreased significantly. A number of companies have bowed out from the market. Other companies had to reorganize their planning completely. In the bulk business, at least the solar cell produces as well as solar module produces have lost the contact. These produces only have the possibility of the withdrawal into the niche market. The picture looks better in the area of producers of inverters.

  3. Yaşar Şâdi Efendi’nin “Hutût-ı Meşâhir” İsimli Hatıra Defteri ve Muhtevası

    OpenAIRE

    BERK, Süleyman

    2015-01-01

    The periodicals of “Hutût-ı Meşâhir” can be considered as a type of journal. (Hutût-i meşâhir: The writings of celebrities) Many different people may be offered to write on these journals with their handwriting and they are expected to express themselves via anything like poems, aphorism or any other artistic skills spontaneously. The most comprehensive journal among the reprints of “Hutût-ı Meşâhir” that are discovered up to now, is the one that belongs to Yaşar Sadi. In the period coveri...

  4. 1:0 for Spain. After the soccer World Championship, Spain won an important solar contest in South Africa; 1:0 fuer Spanien. Nach der Fussball-WM hat Spanien in Suedafrika nun einen wichtigen Solarwettbewerb gewonnen

    Energy Technology Data Exchange (ETDEWEB)

    Rosell, Alejandro Diego; Mattke, Sascha

    2012-03-15

    Spanish manufacturers acquired more orders for construction of industrial-scale PV systems in South Africa than their competitors from other countries. German manufacturers managed to get contracts as partners in several projects.

  5. The judgement of the Federal Constitutional Court on the nuclear phase-out in Germany. Every light hat its shadow; Das Urteil des BVerfG zum Atomausstieg in Deutschland. Licht und Schatten

    Energy Technology Data Exchange (ETDEWEB)

    Leidinger, Tobias [Luther Rechtsanwaltsgesellschaft, Duesseldorf (Germany)

    2017-01-15

    The 13th amendment of the German Atomic Energy Act (AtG) was a direct result of the accident in Fukushima in March 2011. As a result, not only the provisional (three-month) shutdown of the eight nuclear power plants immediately shut down after the accident finally passed the parliament, but fixed shutdown times were also decided for the remaining nine NPP's. This was both an increase of the AtG amendment of 2002 and the extension of the NPP licenses decided a few months earlier. Nuclear energy should therefore continue to serve as a ''bridge technology'' within the framework of the Federal Government's energy concept for a longer period. On 6 December 2016 the Federal Constitutional Court (BVerfG) has decided that the act on the accelerated phasing-out of nuclear energy in Germany is partly unconstitutional. The judgment is clear on a whole series of legal issues. At the same time, it raises new questions with a view to the final clarification of the compensation.

  6. Gaby Temme, Christine Künzel (Hg.: Hat Strafrecht ein Geschlecht? Zur Deutung und Bedeutung der Kategorie Geschlecht in strafrechtlichen Diskursen vom 18. Jahrhundert bis heute. Bielefeld: transcript Verlag 2010.

    Directory of Open Access Journals (Sweden)

    Monika Frommel

    2011-03-01

    Full Text Available Das moderne Strafrecht sollte informelle Geschlechternormen neutralisieren. Dies gelingt auch, kann aber bei der Strafzumessung unterlaufen werden. Wie der vorliegende Band in historisch ausgerichteten Einzelstudien zeigt, war das Strafrecht nie so objektivierend, wie es die Reformen seit den 1970er Jahren anstreben. Am Beispiel der Kindsmörderin wird nachgewiesen, dass der Verstoß gegen Geschlechtertugenden auch heute noch jederzeit mit harten Strafen sanktioniert werden kann.Modern criminal law should neutralize informal gender norms. This is by and large successful; however, it can be circumvented in the assessment of penalty. As shown by the historically orientated individual articles of this anthology, criminal law has never been as objectifying as the reforms since the 1970s are aspiring. Using the example of the female infanticide, the anthology proves that the violation of gender virtues can at all times still be sanctioned with severe penalties.

  7. „Ob man an die kleinen Kinder gedacht hat ...?“ Die Verhandlungen über medizinische Hilfe für deutsche Flüchtlinge in Dänemark am Ende des Zweiten Weltkriegs.

    Directory of Open Access Journals (Sweden)

    Michael Schultheiss

    2009-12-01

    Full Text Available At the beginning of May 1945 almost 250.000 refugees from the eastern parts of Germany were in Denmark, having been evacuated into the occupied kingdom. From the arrival of the first refugee in February until the German capitulation in Denmark on May 5, 1945, 6.580 refugees lost their lives. Among them were more than 4.000 children who mostly died of malnutrition and pneumonia.This article examines the reasons behind this death toll and sheds light on the negotiations pertaining to medical help for the refugees between the Danish administration and the German authorities. However, due to egoistical and political considerations both on the German and Danish sides, an agreement was never settled upon.

  8. Solar beats wind. Bundesnetzagentur counted 3.8 GW of newly installed solar capacity in 2009; Solar schlaegt Wind. Die Bundesnetzagentur hat fuer 2009 3,8 Gigawatt neue Solarleistung gezaehlt

    Energy Technology Data Exchange (ETDEWEB)

    Podewils, Christoph

    2010-05-15

    This is the first detail analysis ever of the German solar market, based on the solar power plant register published by the Bundesnetzagentur shortly after Easter. The result was surprising: Solar power plants with a total power of nearly 1.5 GW were commissioned in December 2009. In all, the German solar market approached the 4 GW mark in 2009. So far, there has been no public debate, and even the BSW-Solar association issued only scarce comments. (orig.)

  9. "Kann jemand, der diese Musik gehört hat, […] noch ein schlechter Mensch sein?" – om Wieslers forandring og kunstens påståtte rolle i denne prosessen

    Directory of Open Access Journals (Sweden)

    Roswitha Skare

    2012-10-01

    Full Text Available The Life of Others (2006 has been a successful film, winning the Oscar for Best Foreign Feature in 2007. It is a film about surveillance, but also about  the lives of artists and writers in East Berlin in the middle of the 1980s, and about what role  literature and art played in the GDR and in the events of autumn 1989. The article focuses on the way the film portrays Wiesler’s transformation from hard-boiled Stasi officer into the guardian angel of his target, and shows how art – both literature and music – plays an important role in this process.

  10. Science Initiatives of the US Virtual Astronomical Observatory

    Science.gov (United States)

    Hanisch, R. J.

    2012-09-01

    The United States Virtual Astronomical Observatory program is the operational facility successor to the National Virtual Observatory development project. The primary goal of the US VAO is to build on the standards, protocols, and associated infrastructure developed by NVO and the International Virtual Observatory Alliance partners and to bring to fruition a suite of applications and web-based tools that greatly enhance the research productivity of professional astronomers. To this end, and guided by the advice of our Science Council (Fabbiano et al. 2011), we have focused on five science initiatives in the first two years of VAO operations: 1) scalable cross-comparisons between astronomical source catalogs, 2) dynamic spectral energy distribution construction, visualization, and model fitting, 3) integration and periodogram analysis of time series data from the Harvard Time Series Center and NASA Star and Exoplanet Database, 4) integration of VO data discovery and access tools into the IRAF data analysis environment, and 5) a web-based portal to VO data discovery, access, and display tools. We are also developing tools for data linking and semantic discovery, and have a plan for providing data mining and advanced statistical analysis resources for VAO users. Initial versions of these applications and web-based services are being released over the course of the summer and fall of 2011, with further updates and enhancements planned for throughout 2012 and beyond.

  11. Hemodynamics in stented vertebral artery ostial stenosis based on computational fluid dynamics simulations.

    Science.gov (United States)

    Qiao, Aike; Dai, Xuan; Niu, Jing; Jiao, Liqun

    2016-01-01

    Hemodynamic factors may affect the potential occurrence of in-stent restenosis (ISR) after intervention procedure of vertebral artery ostial stenosis (VAOS). The purpose of the present study is to investigate the influence of stent protrusion length in implantation strategy on the local hemodynamics of the VAOS. CTA images of a 58-year-old female patient with posterior circulation transient ischemic attack were used to perform a 3D reconstruction of the vertebral artery. Five models of the vertebral artery before and after the stent implantation were established. Model 1 was without stent implantation, Model 2-5 was with stent protruding into the subclavian artery for 0, 1, 2, 3 mm, respectively. Computational fluid dynamics simulations based on finite element analysis were employed to mimic the blood flow in arteries and to assess hemodynamic conditions, particularly the blood flow velocity and wall shear stress (WSS). The WSS and the blood flow velocity at the vertebral artery ostium were reduced by 85.33 and 35.36% respectively after stents implantation. The phenomenon of helical flow disappeared. Hemodynamics comparison showed that stent struts that protruded 1 mm into the subclavian artery induced the least decrease in blood speed and WSS. The results suggest that stent implantation can improve the hemodynamics of VAOS, while stent struts that had protruded 1 mm into the subclavian artery would result in less thrombogenesis and neointimal hyperplasia and most likely decrease the risk of ISR.

  12. Science Initiatives of the US Virtual Astronomical Observatory

    Directory of Open Access Journals (Sweden)

    Hanisch Robert J.

    2012-09-01

    Full Text Available The United States Virtual Astronomical Observatory program is the operational facility successor to the National Virtual Observatory development project. The primary goal of the US VAO is to build on the standards, protocols, and associated infrastructure developed by NVO and the International Virtual Observatory Alliance partners and to bring to fruition a suite of applications and web-based tools that greatly enhance the research productivity of professional astronomers. To this end, and guided by the advice of our Science Council (advisory committee, we are focusing on five science initiatives in the first two years of VAO operations: (1 scalable cross-comparisons between astronomical source catalogs, (2 dynamic spectral energy distribution construction, visualization, and model fitting, (3 integration and periodogram analysis of time series data from the Harvard Time Series Center and NASA Star and Exoplanet Database, (4 integration of VO data discovery and access tools into the IR AF data analysis environment, and (5 a web-based portal to VO data discovery, access, and display tools. We are also developing tools for data linking and semantic discovery, and have a plan for providing data mining and advanced statistical analysis resources for VAO users. Initial versions of these applications and web-based services are being released over the course of the summer and fall of 2011, with further updates and enhancements planned for throughout 2012 and beyond.

  13. Aproximació a les conceptualitzacions gramaticals d’alumnes de secundària a propòsit de les classes de mots

    OpenAIRE

    Macià, Jaume

    2007-01-01

    El treball vol aprofundir en les conceptualitzacions gramaticals dels alumnes de secundària, particularment en els sabers que mobilitzen quan han de determinar la classe lèxica de certes paraules (els mots analitzats pertanyen a categories “simples” com les de nom, verb, adjectiu i adverbi). Per a tal fi s'han enquestat 141 alumnes i se n'han entrevistat 18 (es tracta d'estudiants de tots els nivells de secundària d'un mateix institut). L'estudi posa en evidència la diversitat de procediments...

  14. The unknown risk of vertical transmission in sleeping sickness--a literature review.

    Directory of Open Access Journals (Sweden)

    Andreas K Lindner

    Full Text Available BACKGROUND: Children with human African trypanosomiasis (HAT present with a range of generally non-specific symptoms. Late diagnosis is frequent with often tragic outcomes. Trypanosomes can infect the foetus by crossing the placenta. Unequivocal cases of congenital infection that have been reported include newborn babies of infected mothers who were diagnosed with HAT in the first 5 days of life and children of infected mothers who had never entered an endemic country themselves. METHODS: This review systematically summarizes the literature on the vertical transmission of HAT, to our knowledge for the first time. To approach the broader aspects of the subject, articles considering the epidemiology of childhood HAT and HAT in pregnancy were also included. The HAT guidelines and technical reports of the World Health Organisation, Médecins Sans Frontières, Institut de Recherche pour le Développement, and of one endemic country were reviewed. RESULTS: Publications describing congenital HAT are very limited and consist only of single case reports and small case series. Generally it is assumed to be a rare event, but it has never been systematically investigated. In two publications, it is hypothesized that congenital HAT occurs more often than suspected. Not all guidelines and not all HAT literature mention this transmission route. CONCLUSIONS: The risk of vertical transmission is unknown. Awareness of congenital HAT is insufficient, and as a result opportunities for an early diagnosis in newborns may be missed. All HAT guidelines and local HAT protocols should stress that in endemic areas pregnant women should be systematically checked for HAT and that newborns of HAT infected mothers should be assessed for the disease as soon as possible. Studies on the impact of HAT on fertility and pregnancy and studies on congenital HAT are long overdue.

  15. The Evolution of a Symbol: Mokorotlo and National Identity in Lesotho

    African Journals Online (AJOL)

    The conical grass hat known as Mokorotlo is considered to be part of the national dress of Lesotho. This paper will trace the physical and cultural evolution of the hat, as part of the emergence of a national identity in Lesotho during the twentieth century. The level of cultural prominence which these hats have obtained ...

  16. Matrix transformation of Fibonacci band matrix on generalized $bv$-space and its dual spaces

    Directory of Open Access Journals (Sweden)

    Anupam Das

    2018-07-01

    Full Text Available In this paper we introduce a new sequence space $bv(\\hat{F}$ by using the Fibonacci band matrix $\\hat{F}.$ We also establish a few inclusion relations concerning this space and determine its $\\alpha-,\\beta-,\\gamma-$duals. Finally we characterize some matrix classes on the space $bv(\\hat{F}.$

  17. Subregion-Specific p300 Conditional Knock-Out Mice Exhibit Long-Term Memory Impairments

    Science.gov (United States)

    Oliveira, Ana M. M.; Estevez, Marcel A.; Hawk, Joshua D.; Grimes, Shannon; Brindle, Paul K.; Abel, Ted

    2011-01-01

    Histone acetylation plays a critical role during long-term memory formation. Several studies have demonstrated that the histone acetyltransferase (HAT) CBP is required during long-term memory formation, but the involvement of other HAT proteins has not been extensively investigated. The HATs CBP and p300 have at least 400 described interacting…

  18. A Phase III Diagnostic Accuracy Study of a Rapid Diagnostic Test for Diagnosis of Second-Stage Human African Trypanosomiasis in the Democratic Republic of the Congo

    Directory of Open Access Journals (Sweden)

    Marleen Boelaert

    2018-01-01

    Conclusion: The high sensitivity of the HAT Sero K-SeT is in line with previously published estimates, though the sample of HAT cases in this study was small. The specificity estimate was very high and precise. This test, when negative, allows the clinician to rule out HAT in a clinical suspect in a hospital setting in this endemic region.

  19. Managing distributed software development in the Virtual Astronomical Observatory

    Science.gov (United States)

    Evans, Janet D.; Plante, Raymond L.; Boneventura, Nina; Busko, Ivo; Cresitello-Dittmar, Mark; D'Abrusco, Raffaele; Doe, Stephen; Ebert, Rick; Laurino, Omar; Pevunova, Olga; Refsdal, Brian; Thomas, Brian

    2012-09-01

    The U.S. Virtual Astronomical Observatory (VAO) is a product-driven organization that provides new scientific research capabilities to the astronomical community. Software development for the VAO follows a lightweight framework that guides development of science applications and infrastructure. Challenges to be overcome include distributed development teams, part-time efforts, and highly constrained schedules. We describe the process we followed to conquer these challenges while developing Iris, the VAO application for analysis of 1-D astronomical spectral energy distributions (SEDs). Iris was successfully built and released in less than a year with a team distributed across four institutions. The project followed existing International Virtual Observatory Alliance inter-operability standards for spectral data and contributed a SED library as a by-product of the project. We emphasize lessons learned that will be folded into future development efforts. In our experience, a well-defined process that provides guidelines to ensure the project is cohesive and stays on track is key to success. Internal product deliveries with a planned test and feedback loop are critical. Release candidates are measured against use cases established early in the process, and provide the opportunity to assess priorities and make course corrections during development. Also key is the participation of a stakeholder such as a lead scientist who manages the technical questions, advises on priorities, and is actively involved as a lead tester. Finally, frequent scheduled communications (for example a bi-weekly tele-conference) assure issues are resolved quickly and the team is working toward a common vision.

  20. All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 3. (Lomita, California-San Bernardino, California).

    Science.gov (United States)

    1988-01-01

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  1. Vastased tähistavad ette Saakashvili põrmustumist / Triin Oppi, Evelyn Kaldoja

    Index Scriptorium Estoniae

    Oppi, Triin

    2007-01-01

    Gruusias toimunud meeleavalduste mahasurumisest, president Mihheil Saakashvili poolt väljakuulutatud eriolukorrast ja erakorralistest valimistest ning läänemaailma suhtumisest. Kaart: Gruusia. Kommenteerivad Riigikogu Euroopa Liidu asjade komisjoni esimees Marko Mihkelson ja Thbilisi kaitseuuringute keskuse politoloog Bidzina Lebanidze. Vt. samas: Ilves ja Paet veensid grusiine rahu otsima. Välisminister Urmas Paet ja president Toomas Hendrik Ilves helistasid oma Gruusia kolleegidele, et neilt toimuva kohta aru pärida. President T.H. Ilves rõhutas Gruusia ametivennale vajadust kõiki pooli vaos hoida

  2. Operation HARDTACK. Volume 2. Radiological Safety. Extracted Version

    Science.gov (United States)

    1979-10-01

    8217 ,-- vAo pc-blcm.rrn f tzf ,C thW’ c:m thipt c-pr-t-16-M, Cormni- 𔃼Z 2Int2.Z’ pIi-iv ’.: LL’h. bz. ~ vih th Bou-.r and mo’RIt-. ’J%-, f~ei-)m F&6 V...3--n Prancisco, Califor.a 7 Au-, ist 1058 *EN11 FTOK C--S7.7n) "-T! UM A1JC’.UCIT 195C SeLee rslx 1009.S mb: Vi sj’lit-v 1mie !-eatber Pone CLOUDS

  3. Spatial predictions of Rhodesian Human African Trypanosomiasis (sleeping sickness prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda.

    Directory of Open Access Journals (Sweden)

    Nicola A Batchelor

    2009-12-01

    Full Text Available The continued northwards spread of Rhodesian sleeping sickness or Human African Trypanosomiasis (HAT within Uganda is raising concerns of overlap with the Gambian form of the disease. Disease convergence would result in compromised diagnosis and treatment for HAT. Spatial determinants for HAT are poorly understood across small areas. This study examines the relationships between Rhodesian HAT and several environmental, climatic and social factors in two newly affected districts, Kaberamaido and Dokolo. A one-step logistic regression analysis of HAT prevalence and a two-step logistic regression method permitted separate analysis of both HAT occurrence and HAT prevalence. Both the occurrence and prevalence of HAT were negatively correlated with distance to the closest livestock market in all models. The significance of distance to the closest livestock market strongly indicates that HAT may have been introduced to this previously unaffected area via the movement of infected, untreated livestock from endemic areas. This illustrates the importance of the animal reservoir in disease transmission, and highlights the need for trypanosomiasis control in livestock and the stringent implementation of regulations requiring the treatment of cattle prior to sale at livestock markets to prevent any further spread of Rhodesian HAT within Uganda.

  4. The relationship between the biomass of Cameroonian tropical forests and radiation reflected in middle infrared wavelengths (3.0-5.0 micro m)

    International Nuclear Information System (INIS)

    Boyd, D.S.; Foody, G.M.; Curran, P.J.

    1999-01-01

    The continued northwards spread of Rhodesian sleeping sickness or Human African Trypanosomiasis (HAT) within Uganda is raising concerns of overlap with the Gambian form of the disease. Disease convergence would result in compromised diagnosis and treatment for HAT. Spatial determinants for HAT are poorly understood across small areas. This study examines the relationships between Rhodesian HAT and several environmental, climatic and social factors in two newly affected districts, Kaberamaido and Dokolo. A one-step logistic regression analysis of HAT prevalence and a two-step logistic regression method permitted separate analysis of both HAT occurrence and HAT prevalence. Both the occurrence and prevalence of HAT were negatively correlated with distance to the closest livestock market in all models. The significance of distance to the closest livestock market strongly indicates that HAT may have been introduced to this previously unaffected area via the movement of infected, untreated livestock from endemic areas. This illustrates the importance of the animal reservoir in disease transmission, and highlights the need for trypanosomiasis control in livestock and the stringent implementation of regulations requiring the treatment of cattle prior to sale at livestock markets to prevent any further spread of Rhodesian HAT within Uganda. (author)

  5. New concepts for power generation in three dams on the Iller river. Concepts in dependence of underwater supporting strength; Gewaehrleistung der Energieumwandlung an drei Iller-Staustufen. Konzepte in Abhaengigkeit von der Unterwasserstuetzkraft

    Energy Technology Data Exchange (ETDEWEB)

    Lang, T. [Technische Univ. Muenchen, Obernach (Germany). Versuchsanstalt fuer Wasserbau und Wassermengenwirtschaft; Klocke, R. [Lech-Elektrizitaetswerke AG, Augsburg (Germany)

    1998-07-01

    After 50 years of operation, Lech-Elektrizitaetswerke AG, Augsburg (LEW) intend to modernize their hydroelectric power stations on the upper Iller river. New concepts will be developed for three further dams in order to avoid a costly new construction project at Tosbecken. For this purpose, LEW authorized the Institute of Experimental Hydrological Engineering at Obernach (VAO) of TU Munich University to develop concepts and test them in model experiments. The contribution presents a number of concepts adapted to the dam under investigation. [German] In einem Zeitraum von 10 Jahren plant die Lech-Elektrizitaetswerke AG, Augsburg (LEW) ihre Wasserkraftwerke an der oberen Iller nach 50jaehrigem Betrieb zu ueberholen. Fuer drei weitere Illerstufen sollten aufgrund der vorliegenden Erfahrungen neue Konzepte entwickelt werden. Ziel war es, den aufwendigen Tosbeckenneubau durch kostenguenstigere Massnahmen zur Energieumwandlung zu ersetzen. Zu diesem Zweck beauftragte die LEW die Versuchsanstalt fuer Wasserbau in Obernach (VAO) der Technischen Universitaet Muenchen (TUM) Konzepte zu entwickeln und deren Wirksamkeit anhand von Modellversuchen zu ueberpruefen. Im folgenden Beitrag werden verschiedene, an die jeweilige Situation der Staustufe angepasste, Konzepte zur Energieumwandlung vorgestellt. (orig.)

  6. The Kyoto meeting has given a clear signal. The 3rd conference of signatory states to the UN Framework Convention on Climate Change: Current situation, negotiation dynamics, results; Kyoto-Gipfel hat deutliches Signal gesetzt. Die 3. VSK zur KRK: Ausgangslage, Verhandlungsdynamik, Ergebnis

    Energy Technology Data Exchange (ETDEWEB)

    Lamprecht, F.

    1998-01-01

    This third meeting of the Parties to the UN Framework Convention on Climate Change, held from 1-10 December 1997 in Kyoto/Japan, on which high expectations had been placed, just as on the Berlin meeting two years ago, has certainly not come up to expectations, but still agreed upon a Protocol that can be called an important signpost in international policy for protection of the environment. The envisaged greenhouse gas reduction by 5.2 per cent (of 1990 emissions) laid down in the Protocol, to be achieved by the industrialized countries either individually or by Joint Implementation over the period from 2008 until 2012, is a positive result considering the present situation. Although the agreed cutback falls short of the figures given by climate experts (who demand at least a 20% reduction by the year 2005), the obligation of the USA, the worldwide biggest emitter of greenhouse gases, to achieve a mandatory minimum cutback in emissions of 7% can be considered a big success. (orig./CB) [Deutsch] Auf der wie vor zwei Jahren in Berlin mit stark ueberzogenen Erwartungen ueberfrachteten 3. Vertragsstaatenkonferenz (VSK) zur Klimarahmenkonvention (KRK) vom 1.-10. Dezember 1997 in Kyoto/Japan ist ein zwar bescheidender, aber wichtiger Meilenstein der internationalen Umweltpoltik gesetzt worden. Die im Kyoto-Protokoll festgeschriebene, von den Industrielaendern individuell oder gemeinsam in der Periode 2008-2012 im Durchschnitt zu erzielende Treibhausgasreduktion von insgesamt 5,2% (Basis 1990) ist, gemessen an der Ausgangslage, positiv zu werten. Wenngleich damit die Forderung der Klimaforscher (mindestens 20%-Reduktion bis 2005) nicht erreicht wurde, muss die 7%-Minderungsverpflichtung des weltgroessten Treibhausgasemittenten USA als grosser Erfolg gesehen werden. (orig./RHM)

  7. A határon túli vasútállomások neve a vasúti utastájékoztatásban. [Names for railway stations beyond the borders of Hungary in information services for railway passengers

    Directory of Open Access Journals (Sweden)

    Perger, Imre

    2013-12-01

    Full Text Available This paper presents the problems in identifying the contemporary Hungarian names for railway stations in the Carpathian Basin that formerly were known only by their Hungarian names. The author describes the changes of the names for the relevant settlements as well as those of the names for their railway stations from the time of the official settlement names standardization up to the present (i.e. between 1898 and 2013, which have led to misunderstandings in everyday communication and, especially, in information services for railway passengers. The paper presents the international rules and requirements for naming railway stations, and discusses the relevant regulations by the Hungarian Railways. The author explains why the Hungarian names cannot be used in timetables and why the exclusive use of Hungarian names for railway stations beyond the borders of the present-day Hungary cannot be claimed in information services. The author also discusses the queries on name use posed by the Hungarian Railways to the Hungarian Committee on Geographical Names; and based on the decisions involving an accepted list of railway station names, summarizes the principles to be followed in name use, exploring the professional background of the actual decisions. Because of the lack of unified practice concerning the use of the Hungarian names for settlements beyond the borders of the present-day Hungary, the author initiates the compilation of a standardized historical and administrative gazetteer.

  8. Foglalkoztatási lehetőségek a határon túl – avagy a migrációs folyamatok vizsgálata a kelet-közép-európai térben (Employment Opportunities beyond the Border – Analysis of Migration Trends in Central-Eastern-European Space

    Directory of Open Access Journals (Sweden)

    Katalin Lipták

    2015-12-01

    Full Text Available In this study I examine the main factors of migration, in particular to globalization, as well as the unemployment. This factor affects the migration processes. The main effect of globalization on labor market is manifested most in demand for labor flexibility and growth rather than an overall reduction in demand site. The factors of production in the global economy will be higher mobility than before, so the workforce as an economic factor in the globalization movement across national boundaries thereof. The processes associated with adverse global decline in the working age population (whose evolution I demonstrate this with calculating the Hoover index. A variety of factors can not easily be separated from each other of migration trends with respect. An increasing number of skilled workers get work in Eastern Europe.

  9. William Wordsworth's 'Double Awareness' of Memory in Virginia Woolf's Mrs Dalloway = William Wordsworth'un 'Hatıranın Çift Yönlü Algılaması' Kavramının Virgina Woolf'un Mrs Dalloway Adlı Romanındaki Kullanımı

    Directory of Open Access Journals (Sweden)

    Ali GÜNEŞ

    2003-06-01

    Full Text Available This article deals with Romanticism in modernist British writer Virginia Woolf's novel, Mrs Dalloway. Although her works are experimental and new, they are part of a wider and developing perspective in the historical process of literary tradition, so that they cannot be viewed as completely breaking away from literary tradition, but rather as a reworking and redevelopment in its evolution. In her reworking of the traditional novel, this paper may suggest that Woolf made it "new" by returning to the Romantics, particularly to Wordsworth. By this claim, this paper does not mean that Woolf copied Wordsworth exactly, but was profoundly and pervasively influenced by his aesthetic views, especially in relation to her understanding of life as "consciousness". By returning to the Romantics, Woolf develops her sense of "reality" as both fragmented and whole, and of the "self" as fragmented but desiring and imagining unity. Hence she not only strove to construct a poetical or lyrical novel to express that contradictory view but also used her fiction to explore the mystery of the subjective consciousness as the dominant modernist view. In order to express her perception of modernist identity, Woolf used memory as a device in Mrs Dalloway and thus developed a new way of narration as well as a new view of human identity. By means of this new method, she left the objective narration of the traditional novel, and thus meaning or the view of identity in Woolf's late fiction is not static but undecided, unfinished and mysterious.

  10. Birleştirme-II Tekniğinin Fransızca Okuma Dersinde Öğrenilen Sözcükleri Hatırda Tutmaya Etkisi (Effect of Jigsaw-II on the Retention of New Words Learned in the Course of Reading in French

    Directory of Open Access Journals (Sweden)

    Zühre YILMAZ GÜNGÖR

    2011-10-01

    Full Text Available The purpose of this research is to find the effect of the Jigsaw-II technique regarding the retention of new words learned in the French reading course conducted with freshman of the French Foreign Language Department. In this research, comparative unsynchronized group post-test model was used. The participants of this research are 1st year students studying in the French Foreign Language Department of the Anadolu University (Eskişehir during the spring semester of the academic year 2009-2010. There were 16 participants in the experimental group, 14 participants in the control group. The data were analyzed by analysis of frequency and percentage. As a result, in contrast to the control group using traditional teaching methods, students of the experimental group were greatly remembered new words learned in French reading course.

  11. Székelymagyar nemzeti- és kulturálisidentitás-stratégiák a trianoni határokon túl (Székely-Hungarian National and Cultural Identity Strategies beyond the Trianon Borders

    Directory of Open Access Journals (Sweden)

    Erzsébet Dani

    2016-10-01

    Full Text Available In twenty-first century Europe the issue of majority/minority conflicts, national identity, and different forms of intercultural communication have become more and more foregrounded. Hungarian identity is a complex problematic in itself because Hungary suffered a serious historical trauma as a result of the 1921 Trianon treaties, in which Székely-Hungarians present an interesting case. This ethnic group had always had an identity of its own in Transylvania. However, the post-Trianon situation differs in that while formerly the Székelys defined themselves and claimed self-determination within (Hungarian culture, they now found themselves in a multicultural world, in which no permissive multiculturality was allowed in the sense we conceive multiculturalism today. They were trapped in an antagonistic intercultural situation, where the borders were redrawn around them so that without leaving their homeland they nevertheless became beyond-the-borders citizens, which has led them to the need to apply various identitymanagement strategies. Post-Trianon Székely literature documents this very struggle of intercultural communication and identity-management strategies. Paradoxically, Transylvanian literature owes its existence as an autonomous entity to Trianon. It is by examining literary texts by Áron Tamási, Rózsa Ignácz, and György Bözödi that I am going to set up a typology of identity-management as reflected in the literature under discussion, a typology which this literature would not yield through traditional critical methods, and one which could be helpful in dealing not only with Székely literature in particular, but with contemporary European intercultural communicative crises in general.

  12. Chernobyl - 30 years thereafter. Has radiation protection in Switzerland been improved for the handling of emergency situations and the long-term consequences?; Tschernobyl. 30 Jahre danach. Hat sich der Strahlenschutz in der Schweiz zur Bewaeltigung einer Notfallsituation und deren langfristiger Konsequenzen verbessert?

    Energy Technology Data Exchange (ETDEWEB)

    Murith, Christophe [Bundesamt fuer Gesundheit (BAG), Bern (Switzerland). Abt. Strahlenschutz

    2016-05-01

    30 years ago the Chernobyl reactor accident has surprised the whole world. It was shown that severe nuclear accidents contaminating large areas for a long time are possible. At this time each state was overstrained and unable to cope with the situation. Switzerland was oscillating between the French disregard and the German psychosis resulting in chaotic communication increased by incoherency and missing consultation with the neighboring countries.

  13. Entanglement Potential Versus Negativity of Wigner Function for SUP-Operated Quantum States

    Science.gov (United States)

    Chatterjee, Arpita

    2018-02-01

    We construct a distinct category of nonclassical quantum states by applying a superposition of products (SUP) of field annihilation (\\hat {a}) and creation (\\hat {a}^{\\dagger }) operators of the type (s\\hat {a}\\hat {a}^{\\dagger }+t\\hat {a}^{\\dagger }\\hat {a}), with s2+t2=1, upon thermal and even coherent states. We allow these SUP operated states to undergo a decoherence process and then describe the nonclassical features of the resulted field by using the entanglement potential (EP) and the negativity of the Wigner distribution function. Our analysis reveals that both the measures are reduced in the linear loss process. The partial negativity of the Wigner function disappears when losses exceed 50% but EP exists always.

  14. Demonstration of Human-Autonomy Teaming Principles

    Science.gov (United States)

    Shively, Robert Jay

    2016-01-01

    Known problems with automation include lack of mode awareness, automation brittleness, and risk of miscalibrated trust. Human-Autonomy Teaming (HAT) is essential for improving these problems. We have identified some critical components of HAT and ran a part-task study to introduce these components to a ground station that supports flight following of multiple aircraft. Our goal was to demonstrate, evaluate, and refine HAT principles. This presentation provides a brief summary of the study and initial findings.

  15. Accuracy of individual rapid tests for serodiagnosis of gambiense sleeping sickness in West Africa.

    Directory of Open Access Journals (Sweden)

    Vincent Jamonneau

    2015-02-01

    Full Text Available Individual rapid tests for serodiagnosis (RDT of human African trypanosomiasis (HAT are particularly suited for passive screening and surveillance. However, so far, no large scale evaluation of RDTs has been performed for diagnosis of Trypanosoma brucei gambiense HAT in West Africa. The objective of this study was to assess the diagnostic accuracy of 2 commercial HAT-RDTs on stored plasma samples from West Africa.SD Bioline HAT and HAT Sero-K-Set were performed on 722 plasma samples originating from Guinea and Côte d'Ivoire, including 231 parasitologically confirmed HAT patients, 257 healthy controls, and 234 unconfirmed individuals whose blood tested antibody positive in the card agglutination test but negative by parasitological tests. Immune trypanolysis was performed as a reference test for trypanosome specific antibody presence. Sensitivities in HAT patients were respectively 99.6% for SD Bioline HAT, and 99.1% for HAT Sero-K-Set, specificities in healthy controls were respectively 87.9% and 88.3%. Considering combined positivity in both RDTs, increased the specificity significantly (p ≤ 0.0003 to 93.4%, while 98.7% sensitivity was maintained. Specificities in controls were 98.7-99.6% for the combination of one or two RDTs with trypanolysis, maintaining a sensitivity of at least 98.1%.The observed specificity of the single RDTs was relatively low. Serial application of SD Bioline HAT and HAT Sero-K-Set might offer superior specificity compared to a single RDT, maintaining high sensitivity. The combination of one or two RDTs with trypanolysis seems promising for HAT surveillance.

  16. Clinical Presentation and Treatment Outcome of Sleeping Sickness in Sudanese Pre-School Children.

    OpenAIRE

    Eperon, G; Schmid, C; Loutan, L; Chappuis, F

    2007-01-01

    BACKGROUND: Existing data on human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense among children are limited. Here, we described the demographic, clinical, diagnostic, treatment and outcome characteristics of HAT in pre-school children from Kajo-Keji County, South Sudan in comparison with older patients. METHODS: We did a retrospective analysis of HAT patients treated at the Kiri Sleeping Sickness Treatment Centre (SSTC), Kajo-Keji County, from June 2000 to December 2002. R...

  17. Some properties of Generalized Fibonacci difference bounded and $p$-absolutely convergent sequences

    Directory of Open Access Journals (Sweden)

    Bipan Hazarika

    2018-01-01

    Full Text Available The main objective of this paper is to introduced a new sequence space $l_{p}(\\hat{F}(r,s,$ $ 1\\leq p \\leq \\infty$ by using the band matrix $\\hat{F}(r,s.$ We also establish a few inclusion relations concerning this space and determine its $\\alpha-,\\beta-,\\gamma-$duals. We also characterize some matrix classes on the space $l_{p}(\\hat{F}(r,s$ and examine some geometric properties of this space.

  18. Introducción al desarrollo de software

    OpenAIRE

    Pérez López, Josep Anton; Ribas Xirgo, Lluís

    2009-01-01

    El coneixement profund d'un llenguatge de programació parteix no solament de la comprensió del seu lèxic, de la seva sintaxi i de la seva semàntica, sinó que a més requereix la comprensió dels objectius que n'han motivat el desenvolupament. Així doncs, en aquesta unitat es repassa la història del llenguatge de programació C des del prisma de la programació dels computadors. Els programes descrits en un llenguatge de programació com C no els pot executar directament cap màquina. Per tant, é...

  19. Introduction to software development

    OpenAIRE

    Pérez López, Josep Anton; Ribas Xirgo, Lluís

    2009-01-01

    El coneixement profund d'un llenguatge de programació parteix no solament de la comprensió del seu lèxic, de la seva sintaxi i de la seva semàntica, sinó que a més requereix la comprensió dels objectius que n'han motivat el desenvolupament. Així doncs, en aquesta unitat es repassa la història del llenguatge de programació C des del prisma de la programació dels computadors. Els programes descrits en un llenguatge de programació com C no els pot executar directament cap màquina. Per tant, és n...

  20. L'antropologia lingüística : etnografia i conceptes

    OpenAIRE

    Argenter, Joan A. (Joan Albert)

    2011-01-01

    Entenent que la recerca etnogràfica és pròpia de l'antropologia lingüística, l'article se centra en els treballs que n'han fet un ús metodològic i heurístic. Des d'un punt de vista conceptual s'aborden els conceptes de significat social, comunitat i context, i també la funció de la indexicalitat, en particular la no referencial. A continuació, s'identifiquen diversos fenòmens estudiats per la sociolingüística catalana sota aquest patró i se'n destaquen contribucions significatives en...

  1. Oscillator representations for self-adjoint Calogero Hamiltonians

    Energy Technology Data Exchange (ETDEWEB)

    Gitman, D M [Institute of Physics, University of Sao Paulo (Brazil); Tyutin, I V; Voronov, B L, E-mail: gitman@dfn.if.usp.br, E-mail: tyutin@lpi.ru, E-mail: voronov@lpi.ru [Lebedev Physical Institute, Moscow (Russian Federation)

    2011-10-21

    In Gitman et al (2010 J. Phys. A: Math. Theor. 43 145205), we presented a mathematically rigorous quantum-mechanical treatment of a one-dimensional motion of a particle in the Calogero potential V(x) = {alpha}x{sup -2}. We described all possible self-adjoint (s.a.) operators (s.a. Hamiltonians) associated with the differential operation H=-d{sub x}{sup 2}+{alpha}x{sup -2} for the Calogero Hamiltonian. Here, we discuss a new aspect of the problem, the so-called oscillator representations for the Calogero Hamiltonians. As is known, operators of the form N-hat = a-hat{sup +} a-hat and A-hat = a-hat a-hat{sup +} are called operators of oscillator type. Oscillator-type operators possess a number of useful properties in the case when the elementary operators a-hat are closed. It turns out that some s.a. Calogero Hamiltonians allow oscillator-type representations. We describe such Hamiltonians and find the corresponding mutually adjoint elementary operators a-hat and a-hat{sup +}. An oscillator-type representation for a given Hamiltonian is generally not unique. (paper)

  2. Oscillator representations for self-adjoint Calogero Hamiltonians

    International Nuclear Information System (INIS)

    Gitman, D M; Tyutin, I V; Voronov, B L

    2011-01-01

    In Gitman et al (2010 J. Phys. A: Math. Theor. 43 145205), we presented a mathematically rigorous quantum-mechanical treatment of a one-dimensional motion of a particle in the Calogero potential V(x) = αx -2 . We described all possible self-adjoint (s.a.) operators (s.a. Hamiltonians) associated with the differential operation H=-d x 2 +αx -2 for the Calogero Hamiltonian. Here, we discuss a new aspect of the problem, the so-called oscillator representations for the Calogero Hamiltonians. As is known, operators of the form N-hat = a-hat + a-hat and A-hat = a-hat a-hat + are called operators of oscillator type. Oscillator-type operators possess a number of useful properties in the case when the elementary operators a-hat are closed. It turns out that some s.a. Calogero Hamiltonians allow oscillator-type representations. We describe such Hamiltonians and find the corresponding mutually adjoint elementary operators a-hat and a-hat + . An oscillator-type representation for a given Hamiltonian is generally not unique. (paper)

  3. 'n Evaluasie van Pharos Aanleerderwoordeboek vir skole/ Learner's ...

    African Journals Online (AJOL)

    'n Evaluasie van Pharos Aanleerderwoordeboek vir skole/ Learner's Dictionary for Schools en Longman-HAT Afrikaans Dictionary and Grammar for English Speakers in 'n Afrikaanse taalverwerwingskursus op universiteitsvlak.

  4. Estimating the economic and social consequences for patients diagnosed with human African trypanosomiasis in Muchinga, Lusaka and Eastern Provinces of Zambia (2004–2014)

    OpenAIRE

    Mwiinde, Allan Mayaba; Simuunza, Martin; Namangala, Boniface; Chama-Chiliba, Chitalu Miriam; Machila, Noreen; Anderson, Neil; Shaw, Alexandra; Welburn, Susan C.

    2017-01-01

    Background Acute human African trypanosomiasis (rHAT) caused by Trypanosoma brucei rhodesiense is associated with high mortality and is fatal if left untreated. Only a few studies have examined the psychological, social and economic impacts of rHAT. In this study, mixed qualitative and quantitative research methods were used to evaluate the socio-economic impacts of rHAT in Mambwe, Rufunsa, Mpika and Chama Districts of Zambia. Methods Individuals diagnosed with rHAT from 2004 to 2014 were tra...

  5. Factors influencing passive surveillance for T. b. rhodesiense human african trypanosomiasis in Uganda.

    Science.gov (United States)

    Acup, Christine; Bardosh, Kevin Louis; Picozzi, Kim; Waiswa, Charles; Welburn, Susan Christina

    2017-01-01

    Sleeping sickness or Human African Trypanosomiasis (HAT) is a neglected tropical disease of public health importance across much of Sub-Saharan Africa. In Uganda, chronic T. b. gambiense HAT (gHAT) and acute T. b. rhodesiense HAT (rHAT) occur in two large but discrete geographical foci. Both forms are difficult to diagnose, expensive to treat and ultimately fatal in the absence of treatment. The area affected by zoonotic rHAT has been steadily expanding, placing a high burden on local health systems. HAT is a disease of neglected populations and is notorious for being under-reported. Here we examine the factors that influence passive rHAT surveillance within the district health system in four Ugandan districts into which the disease had recently been introduced, focusing on staff knowledge, infrastructure and data management. A mixed methods study was undertaken between 2011 and 2013 in Dokolo, Kaberamaido, Soroti and Serere districts to explore health facility capacity and clinical service provision, diagnostic capacity, HAT knowledge and case reporting. Structured interviews were undertaken with 86 medical personnel, including clinicians, nurses, midwives and technicians across 65 HC-II and HC-III medical facilities, where the health infrastructure was also directly observed. Eleven semi-structured interviews were undertaken with medical staff in each of the three designated HAT treatment facilities (Dokolo, Lwala and Serere HC-IV) in the area. HAT treatment centre case records, collected between 2009 and 2012, were analyzed. Most medical staff in HC-II and HC-III facilities had been made aware of HAT from radio broadcasts, newspapers and by word of mouth, suggestive of a lack of formal training. Key knowledge as regards the causative agent, clinical signs and that HAT drugs are provided free of charge was lower amongst HC-II than HC-III staff. Many respondents did not know whether HAT was endemic in their district. In rHAT specialist treatment centres, staff

  6. Conflict and human African trypanosomiasis.

    Science.gov (United States)

    Berrang-Ford, Lea; Lundine, Jamie; Breau, Sebastien

    2011-02-01

    Human African Trypanosomiasis (HAT) has reemerged in sub-Saharan Africa as a disease of major public health importance. The success of HAT elimination in sub-Saharan Africa is subject to the feasibility of controlling, eliminating, or mitigating the determinants of incidence in affected countries. Conflict has been widely recognized and cited as a contributing factor to the resurgence of HAT in many countries, as well as to continuing HAT incidence in politically unstable and resource-poor regions. Despite extensive anecdotal and qualitative recognition of the role of conflict, there has been no quantitative research of this topic at the population level in affected African countries. We characterize the qualitative and quantitative associations between HAT incidence and conflict-related processes in HAT-affected African countries over the past 30 years. HAT and conflict-related data were collected for 35 affected countries in sub-Saharan Africa for the years 1976-2004. Descriptive and univariate inferential statistics, as well as negative binomial regression modeling, are used to assess the associations between HAT and conflict. A space-time scan statistic is used to identify significant incidence clusters. Clusters of HAT incidence over the past 30 years have predominantly coincided with periods of conflict or socio-political instability. HAT cases occurred significantly more often in countries and during years with conflict, high political terror, and internationalized civil war. The results indicate a lag period between the start of conflict events and a peak in incidence of approximately 10 years. We recommend explicit consideration and quantification of socio-political measures such as conflict and terror indices in GIS (Geographic Information Systems)-based risk assessments for HAT policy and intervention. Copyright © 2010 Elsevier Ltd. All rights reserved.

  7. 78 FR 5205 - Native American Graves Protection and Repatriation Review Committee Findings Related to the...

    Science.gov (United States)

    2013-01-24

    ... than not, that the conveyor of the Clan Hat to the Alaska State Museum had consented to transfer... conveyor to transfer possession of the Clan Hat to the Alaska State Museum was voluntary. By a vote of four... from the Tlingit Teeyh[iacute]ttaan Clan, the transferor consented to transfer possession, the...

  8. Human African Trypanosomiasis and challenges to its control in ...

    African Journals Online (AJOL)

    There was poor capacity for most of the health facilities in the diagnosis, treatment and control of HAT. In both districts, communities were knowledgeable of the tsetse identity (82.4%) and had experienced tsetse bites (94%). The majority (91.4%) of the community members knew that they were at risk of acquiring HAT.

  9. First Things First: Similar List Length and Output Order Effects for Verbal and Nonverbal Stimuli

    Science.gov (United States)

    Cortis, Cathleen; Dent, Kevin; Kennett, Steffan; Ward, Geoff

    2015-01-01

    When participants are presented with a short list of unrelated words and they are instructed that they may recall in any order, they nevertheless show a very strong tendency to recall in forward serial order. Thus, if asked to recall "in any orde"r: "hat, mouse, tea, stairs," participants often respond "hat, mouse, tea,…

  10. Vorgehensmodelle in Deutschland

    DEFF Research Database (Denmark)

    Kuhrmann, Marco; Linssen, Oliver

    2015-01-01

    sich die Anwendung von Vorgehensmodellen über die Zeit entwickelt hat. Die Studie hat gezeigt, dass eine Vielzahl von Vorgehensmodellen im Einsatz ist. Obwohl ein Trend weg von großen Standards zu beobachten ist, werden sowohl agile wie auch klassische Ansätze angewendet. Die Studie zeigt auch, dass...

  11. Histone acetyltransferases : challenges in targeting bi-substrate enzymes

    NARCIS (Netherlands)

    Wapenaar, Hannah; Dekker, Frank J

    2016-01-01

    Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors, and enzymes. HATs have been shown to play a role in diseases ranging from cancer and inflammatory diseases to

  12. Beiträge zu einer kognitiv ausgerichteten Lexikographie

    African Journals Online (AJOL)

    rbr

    Jahrhunderten immer wieder abgelegte Bekenntnis zu dem Satz Sprache dient dem Ausdruck von Gedanken oder einer seiner Varianten zeigt, kognitive Orien- tierung ein altes Programm mit Sprache befaßter Disziplinen ist, hat sich eine. Linguistik, die dieses Programm wirklich auf ihre Fahnen geschrieben hat, erst.

  13. Journal of Agriculture, Forestry and the Social Sciences: Submissions

    African Journals Online (AJOL)

    REFERENCES This should take the format of the current American Psychological Society Association (APA) editorial style. For Books Busola,A.E.(2004) :Hat making in the 21st Century.2nd ed.: Madandola Publishers, Calabar. For Journal articles Busola, A.E.(2004): Hat and Birthday cakes in the humid tropics of Africa and ...

  14. Knowledge and prevalence of Human African Trypanosomiasis ...

    African Journals Online (AJOL)

    Knowledge and prevalence of Human African Trypanosomiasis among residents of Kachia grazing reserve, Kachia local government area, Kaduna state, ... Knowledge of HAT was scored 0-5 and categorized good (3-5) and poor (0-2) based on score, predisposition to risk of HAT as exposure to ≥two risk factors and, ...

  15. Detection of Trypanosoma brucei parasites in blood samples using real-time nucleic acid sequence-based amplification

    NARCIS (Netherlands)

    Mugasa, Claire M.; Schoone, Gerard J.; Ekangu, Rosine A.; Lubega, George W.; Kager, Piet A.; Schallig, Henk D. F. H.

    2008-01-01

    Currently, the conventional diagnosis of human African trypanosomiasis (HAT) is by microscopic demonstration of trypomastigotes in blood, lymph, and/or cerebrospinal fluid. However, microscopic diagnosis of HAT is not sensitive enough and may give false-negative results, thus, denying the patient

  16. Spin Triplet Nematic Pairing Symmetry and Superconducting Double Transition in U1-xThxBe13

    Science.gov (United States)

    Machida, Kazushige

    2018-03-01

    Motivated by a recent experiment on U1-xThxBe13 with x = 3%, we develop a theory to narrow down the possible pair symmetry to consistently describe the double transition utilizing various theoretical tools, including group theory and Ginzburg-Landau theory. It is explained in terms of the two-dimensional representation Eu with spin triplet. Symmetry breaking causes the degenerate Tc to split into two. The low-temperature phase is identified as the cyclic p wave: d(k) = \\hat{x}kx + ɛ \\hat{y}ky + ɛ 2\\hat{z}kz with ɛ3 = 1, whereas the biaxial nematic phase: d(k) = √{3} (\\hat{x}kx - \\hat{y}ky) is the high-temperature one. This allows us to simultaneously identify the uniaxial nematic phase: d(k) = 2\\hat{z}kz - \\hat{x}kx - \\hat{y}ky for UBe13, which spontaneously breaks the cubic symmetry of the system. Those pair functions are fully consistent with this description and existing data. We comment on the accidental scenario in addition to this degeneracy scenario and the intriguing topological nature hidden in this long-known material.

  17. Palladium-Catalyzed Atom-Transfer Radical Cyclization at Remote Unactivated C(sp3 )-H Sites: Hydrogen-Atom Transfer of Hybrid Vinyl Palladium Radical Intermediates.

    Science.gov (United States)

    Ratushnyy, Maxim; Parasram, Marvin; Wang, Yang; Gevorgyan, Vladimir

    2018-03-01

    A novel mild, visible-light-induced palladium-catalyzed hydrogen atom translocation/atom-transfer radical cyclization (HAT/ATRC) cascade has been developed. This protocol involves a 1,5-HAT process of previously unknown hybrid vinyl palladium radical intermediates, thus leading to iodomethyl carbo- and heterocyclic structures. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Die Korallenfauna des Perm von Timor und die permische Vereisung

    NARCIS (Netherlands)

    Gerth, H.

    1926-01-01

    Bei den zahlreichen Rekonstruktionen der klimatologischen Verhältnisse, die man für das Ende des Palaeozoikums gemacht hat, ist man fast immer von der Kohlenbildung, der Florenverbreitung und den Vereisungserscheinungen ausgegangen. Der marinen Tierwelt hat man bei der Behandlung dieser Fragen meist

  19. Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation

    Directory of Open Access Journals (Sweden)

    Wright Anthony PH

    2010-01-01

    Full Text Available Abstract Background Histone acetyltransferase enzymes (HATs are implicated in regulation of transcription. HATs from different families may overlap in target and substrate specificity. Results We isolated the elp3+ gene encoding the histone acetyltransferase subunit of the Elongator complex in fission yeast and characterized the phenotype of an Δelp3 mutant. We examined genetic interactions between Δelp3 and two other HAT mutants, Δmst2 and Δgcn5 and used whole genome microarray analysis to analyze their effects on gene expression. Conclusions Comparison of phenotypes and expression profiles in single, double and triple mutants indicate that these HAT enzymes have overlapping functions. Consistent with this, overlapping specificity in histone H3 acetylation is observed. However, there is no evidence for overlap with another HAT enzyme, encoded by the essential mst1+ gene.

  20. Versatile Auxiliary Orthodontic Spring for Orthodontic Correction of Impacted Teeth

    Directory of Open Access Journals (Sweden)

    Pavankumar Janardan Vibhute

    2011-01-01

    Full Text Available Malocclusion such as impacted tooth is not uncommon. Many approaches with various auxiliary springs have been reported in literature till date for correction of such malocclusions. They had biomechanical, retentive and stability drawbacks inherent in their designs. This article presents the innovative approach for orthodontic correction of impacted tooth, especially with light force appliance, i.e. Begg′s appliance, where round wires in round molar tubes are used throughout treatment. A versatile auxiliary orthodontic spring (VAOS is fabricated in the 0.018 inch Australian stainless steel round wire, which may be anchored on round molar buccal tube, and desirable force vector may be applied in any of the three dimensions. Fabrication and its clinical application are discussed.

  1. Astronomical Data and Information Visualization

    Science.gov (United States)

    Goodman, Alyssa A.

    2010-01-01

    As the size and complexity of data sets increases, the need to "see" them more clearly increases as well. In the past, many scientists saw "fancy" data and information visualization as necessary for "outreach," but not for research. In this talk, I wlll demonstrate, using specific examples, why more and more scientists--not just astronomers--are coming to rely upon the development of new visualization strategies not just to present their data, but to understand it. Principal examples will be drawn from the "Astronomical Medicine" project at Harvard's Initiative in Innovative Computing, and from the "Seamless Astronomy" effort, which is co-sponsored by the VAO (NASA/NSF) and Microsoft Research.

  2. A munkaerő-piaci politika hatása a nemek közötti egyenlőségre a gazdasági átalakulás és az EU-csatlakozás időszakában: Csehország, Magyarország és Szlovénia összehasonlítása

    Czech Academy of Sciences Publication Activity Database

    Nagy, B.; Křížková, Alena; Kanjuo-Mrčela, A.

    2012-01-01

    Roč. 22, č. 1 (2012), s. 30-60 ISSN 1216-2051 R&D Projects: GA ČR GAP404/10/0021 Institutional support: RVO:68378025 Keywords : female employment * gender equality * child care institutions Subject RIV: AO - Sociology, Demography

  3. Factorizing the time evolution operator

    International Nuclear Information System (INIS)

    Garcia Quijas, P C; Arevalo Aguilar, L M

    2007-01-01

    There is a widespread belief in the quantum physical community, and textbooks used to teach quantum mechanics, that it is a difficult task to apply the time evolution operator e itH-hat/h on an initial wavefunction. Because the Hamiltonian operator is, generally, the sum of two operators, then it is not possible to apply the time evolution operator on an initial wavefunction ψ(x, 0), for it implies using terms like (a-hat + b-hat). A possible solution is to factorize the time evolution operator and then apply successively the individual exponential operator on the initial wavefunction. However, the exponential operator does not directly factorize, i.e. e a-hat+b-hat ≠ e a-hat e b-hat . In this study we present a useful procedure for factorizing the time evolution operator when the argument of the exponential is a sum of two operators, which obey specific commutation relations. Then, we apply the exponential operator as an evolution operator for the case of elementary unidimensional potentials, like a particle subject to a constant force and a harmonic oscillator. Also, we discuss an apparent paradox concerning the time evolution operator and non-spreading wave packets addressed previously in the literature

  4. Quantum-Classical Phase Transition of the Escape Rate of Two-Sublattice Antiferromagnetic Large Spins

    Science.gov (United States)

    Owerre, Solomon Akaraka; Paranjape, M. B.

    2014-11-01

    The Hamiltonian of a two-sublattice antiferromagnetic spins, with single (hard-axis) and double ion anisotropies described by H = J {\\hat S}1...\\hatS 2-2Jz \\hat {S}1z\\hat {S}2z+K(\\hat {S}1z2 +\\hat {S}2z2) is investigated using the method of effective potential. The problem is mapped to a single particle quantum-mechanical Hamiltonian in terms of the relative coordinate and reduced mass. We study the quantum-classical phase transition of the escape rate of this model. We show that the first-order phase transition for this model sets in at the critical value Jc = (Kc+Jz, c)/2 while for the anisotropic Heisenberg coupling H = J(S1xS2x +S1yS2y) + JzS1zS2z + K(S1z2+ S2z2) we obtain Jc = (2Kc-Jz, c)/3. The phase diagrams of the transition are also studied.

  5. Human-Autonomy Teaming in a Flight Following Task

    Science.gov (United States)

    Shively, Robert J.

    2017-01-01

    The NATO HFM-247 Working Group is creating a summary report of the group's activities on human-autonomy teaming. This chapter is a summary of our at NASA Ames work toward developing a framework for human-autonomy teaming (HAT) in aviation. The purpose of this project was to demonstrate and evaluate proposed tenets of HAT. The HAT features were derived from three tenets and were built into an automated recommender system on a ground station. These tenets include bi-directional communication, automation transparency, and operator directed interface. This study focused primarily on interactions with one piece of automation, the Autonomous Constrained Flight Planner (ACFP). The ACFP is designed to support rapid diversion decisions for commercial pilots in off-nominal situations. Much effort has gone into enhancing this tool not only in capability but also in transparency. In this study, participants used the ACFP at a ground station designed to aid dispatchers in a flight following role to reroute aircraft in situations such as inclement weather, system failures and medical emergencies. Participants performed this task both with HAT features enabled and without and provided feedback. We examined subjective and behavioral indicators of HAT collaborations using a proof-of-concept demonstration of HAT tenets. The data collected suggest potential advantages and disadvantages of HAT.

  6. Headgear Accessories Classification Using an Overhead Depth Sensor

    Directory of Open Access Journals (Sweden)

    Carlos A. Luna

    2017-08-01

    Full Text Available In this paper, we address the generation of semantic labels describing the headgear accessories carried out by people in a scene under surveillance, only using depth information obtained from a Time-of-Flight (ToF camera placed in an overhead position. We propose a new method for headgear accessories classification based on the design of a robust processing strategy that includes the estimation of a meaningful feature vector that provides the relevant information about the people’s head and shoulder areas. This paper includes a detailed description of the proposed algorithmic approach, and the results obtained in tests with persons with and without headgear accessories, and with different types of hats and caps. In order to evaluate the proposal, a wide experimental validation has been carried out on a fully labeled database (that has been made available to the scientific community, including a broad variety of people and headgear accessories. For the validation, three different levels of detail have been defined, considering a different number of classes: the first level only includes two classes (hat/cap, and no hat/cap, the second one considers three classes (hat, cap and no hat/cap, and the last one includes the full class set with the five classes (no hat/cap, cap, small size hat, medium size hat, and large size hat. The achieved performance is satisfactory in every case: the average classification rates for the first level reaches 95.25%, for the second one is 92.34%, and for the full class set equals 84.60%. In addition, the online stage processing time is 5.75 ms per frame in a standard PC, thus allowing for real-time operation.

  7. Easter

    Institute of Scientific and Technical Information of China (English)

    孟娜

    2016-01-01

    教学内容Look at these children's hats,There are toy chicks,bunnies and flowers on the hats,Do you know why?They are Easter hats.Easter is in spring.On that day,children make Easter eggs with their parents and give eggs to each other.Some Easter eggs are big and some are small.Sometimes there are small eggs in the big eggs,Children also play egg-rolling and egg-hunting for fun.

  8. Challenges of controlling sleeping sickness in areas of violent conflict: experience in the Democratic Republic of Congo.

    Science.gov (United States)

    Tong, Jacqueline; Valverde, Olaf; Mahoudeau, Claude; Yun, Oliver; Chappuis, François

    2011-05-26

    Human African trypanosomiasis (HAT), or sleeping sickness, is a fatal neglected tropical disease if left untreated. HAT primarily affects people living in rural sub-Saharan Africa, often in regions afflicted by violent conflict. Screening and treatment of HAT is complex and resource-intensive, and especially difficult in insecure, resource-constrained settings. The country with the highest endemicity of HAT is the Democratic Republic of Congo (DRC), which has a number of foci of high disease prevalence. We present here the challenges of carrying out HAT control programmes in general and in a conflict-affected region of DRC. We discuss the difficulties of measuring disease burden, medical care complexities, waning international support, and research and development barriers for HAT. In 2007, Médecins Sans Frontières (MSF) began screening for HAT in the Haut-Uélé and Bas-Uélé districts of Orientale Province in northeastern DRC, an area of high prevalence affected by armed conflict. Through early 2009, HAT prevalence rate of 3.4% was found, reaching 10% in some villages. More than 46,000 patients were screened and 1,570 treated for HAT during this time. In March 2009, two treatment centres were forced to close due to insecurity, disrupting patient treatment, follow-up, and transmission-control efforts. One project was reopened in December 2009 when the security situation improved, and another in late 2010 based on concerns that population displacement might reactivate historic foci. In all of 2010, 770 patients were treated at these sites, despite a limited geographical range of action for the mobile teams. In conflict settings where HAT is prevalent, targeted medical interventions are needed to provide care to the patients caught in these areas. Strategies of integrating care into existing health systems may be unfeasible since such infrastructure is often absent in resource-poor contexts. HAT care in conflict areas must balance logistical and medical capacity

  9. Heroin assisted treatment and research networks

    DEFF Research Database (Denmark)

    Houborg, Esben; Munksgaard, Rasmus

    2015-01-01

    Purpose – The purpose of this paper is to map research communities related to heroin-assisted treatment (HAT) and the scientific network they are part of to determine their structure and content. Design/methodology/approach – Co-authorship as the basis for conducting social network analysis....... In total, 11 research communities were constructed with different scientific content. HAT research communities are closely connected to medical, psychiatric, and epidemiological research and very loosely connected to social research. Originality/value – The first mapping of the collaborative network HAT...... researchers using social network methodology...

  10. Auf dem Weg zur Digitalen Bibliothek

    OpenAIRE

    Degkwitz, Andreas; Frank, Nina; Hendrix, Imma; Pfeifenberger, Regina; Tollkühn, Katharina

    2013-01-01

    Nichts hat den Lebensalltag in den vergangenen zwanzig Jahren mehr verändert als das Internet, das uns mit Handys, Laptops, Net- und Notebooks, Smartphones und Tablet-PCs allgegenwärtig begleitet. Das iPhone bietet den permanenten Zugang zu weltweit verfügbarer Information in der Westentasche und hat damit einen völlig neuen Umgang mit Interaktion und Informationsrecherche herbeigeführt. Der tief greifende Wandel hat sich massiv auf die Weiterentwicklung der Serviceprofile wissenschaftl...

  11. Estimating the burden of rhodesiense sleeping sickness during an outbreak in Serere, eastern Uganda

    Directory of Open Access Journals (Sweden)

    Coleman Paul G

    2008-03-01

    Full Text Available Abstract Background Zoonotic sleeping sickness, or HAT (Human African Trypanosomiasis, caused by infection with Trypanosoma brucei rhodesiense, is an under-reported and neglected tropical disease. Previous assessments of the disease burden expressed as Disability-Adjusted Life Years (DALYs for this infection have not distinguished T.b. rhodesiense from infection with the related, but clinically distinct Trypanosoma brucei gambiense form. T.b. rhodesiense occurs focally, and it is important to assess the burden at the scale at which resource-allocation decisions are made. Methods The burden of T.b. rhodesiense was estimated during an outbreak of HAT in Serere, Uganda. We identified the unique characteristics affecting the burden of rhodesiense HAT such as age, severity, level of under-reporting and duration of hospitalisation, and use field data and empirical estimates of these to model the burden imposed by this and other important diseases in this study population. While we modelled DALYs using standard methods, we also modelled uncertainty of our parameter estimates through a simulation approach. We distinguish between early and late stage HAT morbidity, and used disability weightings appropriate for the T.b. rhodesiense form of HAT. We also use a model of under-reporting of HAT to estimate the contribution of un-reported mortality to the overall disease burden in this community, and estimate the cost-effectiveness of hospital-based HAT control. Results Under-reporting accounts for 93% of the DALY estimate of rhodesiense HAT. The ratio of reported malaria cases to reported HAT cases in the same health unit was 133:1, however, the ratio of DALYs was 3:1. The age productive function curve had a close correspondence with the HAT case distribution, and HAT cases occupied more patient admission time in Serere during 1999 than all other infectious diseases other than malaria. The DALY estimate for HAT in Serere shows that the burden is much greater

  12. アイヒマンの悪における「陳腐さ」について

    OpenAIRE

    香月, 恵里

    2016-01-01

    Adolf Eichmann, einer der bekanntesten Täter des Holocaust, der seit 1950 in Argentinien untertaucht war, wurde im Mai 1960 vom israelischen Geheimdienst entführt und saß im folgenden Jahr vor dem Jerusalemer Gericht. Die Philosophin Hannah Arendt hat als Reporterin Eichmann hinter dem Panzerglas im Gericht beobachtet und die Reportage „Eichmann in Jerusalem“ geschrieben. Doch der Untertitel ihres Berichtes, die „Banalität des Bösen“ hat eine wilde Kontroverse ausgelöst. Man hat ihre These al...

  13. Challenges of controlling sleeping sickness in areas of violent conflict: experience in the Democratic Republic of Congo

    Directory of Open Access Journals (Sweden)

    Yun Oliver

    2011-05-01

    Full Text Available Abstract Background Human African trypanosomiasis (HAT, or sleeping sickness, is a fatal neglected tropical disease if left untreated. HAT primarily affects people living in rural sub-Saharan Africa, often in regions afflicted by violent conflict. Screening and treatment of HAT is complex and resource-intensive, and especially difficult in insecure, resource-constrained settings. The country with the highest endemicity of HAT is the Democratic Republic of Congo (DRC, which has a number of foci of high disease prevalence. We present here the challenges of carrying out HAT control programmes in general and in a conflict-affected region of DRC. We discuss the difficulties of measuring disease burden, medical care complexities, waning international support, and research and development barriers for HAT. Discussion In 2007, Médecins Sans Frontières (MSF began screening for HAT in the Haut-Uélé and Bas-Uélé districts of Orientale Province in northeastern DRC, an area of high prevalence affected by armed conflict. Through early 2009, HAT prevalence rate of 3.4% was found, reaching 10% in some villages. More than 46,000 patients were screened and 1,570 treated for HAT during this time. In March 2009, two treatment centres were forced to close due to insecurity, disrupting patient treatment, follow-up, and transmission-control efforts. One project was reopened in December 2009 when the security situation improved, and another in late 2010 based on concerns that population displacement might reactivate historic foci. In all of 2010, 770 patients were treated at these sites, despite a limited geographical range of action for the mobile teams. Summary In conflict settings where HAT is prevalent, targeted medical interventions are needed to provide care to the patients caught in these areas. Strategies of integrating care into existing health systems may be unfeasible since such infrastructure is often absent in resource-poor contexts. HAT care in

  14. Sensitivity of tropical cyclone Jal simulations to physics ...

    Indian Academy of Sciences (India)

    tial to predict a mesoscale weather system. Previ- ous sensitivity studies ... Forecast System (GFS) real time prediction. In this study, the ... time prediction is akin to running a real time fore- cast. Furthermore ...... Operating system. Red hat Linux.

  15. Dynamical correlation functions of the quadratic coupling spin-Boson model

    Science.gov (United States)

    Zheng, Da-Chuan; Tong, Ning-Hua

    2017-06-01

    The spin-boson model with quadratic coupling is studied using the bosonic numerical renormalization group method. We focus on the dynamical auto-correlation functions {C}O(ω ), with the operator \\hat{O} taken as {\\hat{{{σ }}}}x, {\\hat{{{σ }}}}z, and \\hat{X}, respectively. In the weak-coupling regime α qualitatively, showing enhanced dephasing at the spin flip point. Project supported by the National Key Basic Research Program of China (Grant No. 2012CB921704), the National Natural Science Foundation of China (Grant No. 11374362), the Fundamental Research Funds for the Central Universities, China, and the Research Funds of Renmin University of China (Grant No. 15XNLQ03).

  16. Quantitative Zusammensetzung des Gehirns der Mitteleuropäischen Fledermäuse (Rhinolophidae und Vespertilionidae)

    NARCIS (Netherlands)

    Sigmund, Leo; Zajícová, Anna

    1970-01-01

    Die Hirnanalyse der untersuchten Hirnstrukturen von 12 einheimischen Fledermausarten hat gezeigt, dass die Microchiroptera im Hirnbau nicht einheitlich sind. Es lassen sich deutlich die Vertreter der Gattung Myotis, von den Vertretern der Gattung Rhinolophus und Eptesicus unterscheiden. Die Gattung

  17. Race Matters… Still. Rezension zu Tom Angotti und Sylvia Morse (Hg. (2016: Zoned Out! Race, Displacement, and City Planning in New York City. New York City: Terreform.

    Directory of Open Access Journals (Sweden)

    Yuca Meubrink

    2017-06-01

    Full Text Available In ihrem Sammelband Zoned Out! identifizieren Tom Angotti und Sylvia Morse zoning als eines der Planungsinstrumente, welches die historischen Muster ethnischer Diskriminierung und Segregation in New York bis heute immer wieder reproduziert hat. [...

  18. Mixed Estimates for Degenerate Multilinear Operators Associated to Simplexes

    OpenAIRE

    Kesler, Robert

    2013-01-01

    We prove that the degenerate trilinear operator $C_3^{-1,1,1}$ given by the formula \\begin{eqnarray*} C_3^{-1,1,1}(f_1, f_2, f_3)(x)=\\int_{x_1 < x_2 < x_3} \\hat{f_1}(x_1) \\hat{f_2}(x_2) \\hat{f_3}(x_3) e^{2\\pi i x (-x_1 + x_2 + x_3)} dx_1dx_2 dx_3 \\end{eqnarray*} satisfies the new estimates \\begin{eqnarray*} ||C_3^{-1,1,1}(f_1, f_2, f_3)||_{\\frac{1}{\\frac{1}{p_1}+\\frac{1}{p_2}+\\frac{1}{p_3}}} \\lesssim_{p_1, p_2, p_3} ||\\hat{f}_1||_{p^\\prime_1} ||f_2||_{p_2}||f_3||_{p_3} \\end{eqnarray*} for all...

  19. Characterization of High Altitude Turbulence for Air Force Platforms

    National Research Council Canada - National Science Library

    Ruggiero, Frank H; Werne, Joe; Mahalov, Alex; Nichols, Basil; Wroblewski, Donald E

    2007-01-01

    ...) on systems that operate at or propagate through those attitudes. Examples of systems affected by HAT include surveillance aircraft such as the U-2 and the unmanned Global Hawk, developing weapons systems such as the Airborne Laser (ABL...

  20. Safety audits/Verkehrssicherheitsaudits : ein vielsprechendes Instrument zur Förderung der Verkehrssicherheit ?

    NARCIS (Netherlands)

    Wegman, F.C.M. & Schagen, I.N.L.G. van

    1998-01-01

    Das Instrument `Verkehrssicherheitsaudit' (`Audits') hat zum Zweck die infrastrukturellen Bedingungen für Verkehrssicherheit bereits während der Entwurf- und Realisierungsphase der Verkehrsinfrastruktur einzubauen. Dieser Bericht gibt ein Übersicht der Tragweite des Audits. Ausserdem werden

  1. Dandruff: How to Treat

    Medline Plus

    Full Text Available ... from the sun by wearing a hat when outdoors and seeking shade whenever possible. For most people, ... Search Explore the Academy Member resources Practice Tools Education Meetings & events Advocacy Public & patients Academy resources for: ...

  2. Small molecule inhibitors of histone deacetylases and acetyltransferases as potential therapeutics in oncology

    NARCIS (Netherlands)

    van den Bosch, Thea; Leus, Niek; Timmerman, Tirza; Dekker, Frank J

    2016-01-01

    Uncontrolled cell proliferation and resistance to apoptosis in cancer are, among others, regulated by post-translational modifications of histone proteins. The most investigated type of histone modification is lysine acetylation. Histone acetyltransferases (HATs), acetylate histone lysine residues,

  3. Retransplantation in Late Hepatic Artery Thrombosis: Graft Access and Transplant Outcome

    Directory of Open Access Journals (Sweden)

    Bettina M. Buchholz, MD, FEBS

    2017-08-01

    Conclusions. Inequity in graft access and peritransplant sepsis are fundamental obstacles for successful re-LT in L-HAT. Offering a graft for those in need at the best window of opportunity could facilitate earlier engrafting with improved outcomes.

  4. Entwicklung der Reglementierung von 10 MEM-Berufen im Kontext von Bildungsreformen und dem Wandel in der Arbeitswelt: Eine Kurzstudie im Auftrag von LIBS: Eine Kurzstudie im Auftrag von LIBS Industrielle Berufslehren Schweiz, Baden

    OpenAIRE

    Egg, Maria Esther; Renold, Ursula

    2015-01-01

    Im Auftrag der LIBS Industrielle Berufslehren Schweiz, hat die KOF die Entwicklung von 10 MEM1-Berufsbildern seit dem ersten Berufsbildungsgesetz dargestellt und diese eingebettet in eine kurze Zusammenfassung der wichtigsten Etappenschritte des Schweizer Berufsbildungssystems.

  5. "Wir wissen, dass man 2050 über unsere Prognosen lachen wird"

    OpenAIRE

    Gugerli, David

    2011-01-01

    Euro, Atom, Umwelt – es kriselt allenthalben. Historiker David Gugerli ist überzeugt, dass der Glaube an die Technik abgenommen hat. Gleichzeitig wir lernen, mit den vielen Optionen unserer Zeit umzugehen.

  6. Commuting periodic operators and the periodic Wigner function

    International Nuclear Information System (INIS)

    Zak, J

    2004-01-01

    Commuting periodic operators (CPO) depending on the coordinate x-hat and the momentum p-hat operators are defined. The CPO are functions of the two basic commuting operators exp(i x-hat 2π/a) and exp(i/h p-hat a), with a being an arbitrary constant. A periodic Wigner function (PWF) w(x, p) is defined and it is shown that it is applicable in a normal expectation value calculation to the CPO, as done in the original Wigner paper. Moreover, this PWF is non-negative everywhere, and it can therefore be interpreted as an actual probability distribution. The PWF w(x, p) is shown to be given as an expectation value of the periodic Dirac delta function in the phase plane. (letter to the editor)

  7. Turning palm leaves into wood: Opportunities for Egypt's rural ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-04-27

    Apr 27, 2016 ... Bedouin women weave handmade baskets, hats, and lamps using dried palm leaves. ... palm tree leaves into hardwood and high-quality wooden products, ... of wood and open doors to job opportunities for rural communities.

  8. Disease: H01676 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available hat cause inflammation of the arachnoid, such as subarachnoid hemorrhage, traumatic brain injury, or menin...gitis. As many as half of patients with NPH have no identifiable risk factor, and i

  9. Diagnostic Accuracy of Molecular Amplification Tests for Human African Trypanosomiasis-Systematic Review

    NARCIS (Netherlands)

    Mugasa, Claire M.; Adams, Emily R.; Boer, Kimberly R.; Dyserinck, Heleen C.; Büscher, Philippe; Schallig, Henk D. H. F.; Leeflang, Mariska M. G.

    2012-01-01

    Background: A range of molecular amplification techniques have been developed for the diagnosis of Human African Trypanosomiasis (HAT); however, careful evaluation of these tests must precede implementation to ensure their high clinical accuracy. Here, we investigated the diagnostic accuracy of

  10. Rezension: Digitale Körperinnenwelten. Endoskopische 3D-Animationen zwischen Medien und Populärkultur. von Sven Stollfuß

    Directory of Open Access Journals (Sweden)

    Petra Missomelius

    2015-09-01

    Full Text Available Sven Stollfuß’ Studie über die digitale Darstellung körperlicher Innenwelten bewegt sich zwischen medienwissenschaftlicher Theoriebildung, Bildtheorie und Science and Technology Studies. Petra Missomelius hat rezensiert ...

  11. Should You Put Sunscreen on Infants? Not Usually

    Science.gov (United States)

    ... brimmed hats that shade the neck to prevent sunburn. Tight weaves are better than loose. Keep in ... or she doesn’t show warning signs of sunburn or dehydration. These include fussiness, redness and excessive ...

  12. Rezension: Ada Lovelace. Die Pionierin der Computertechnik und ihre Nachfolgerinnen von Sybille Krämer (Hg.)

    OpenAIRE

    Bettina Schabschneider

    2015-01-01

    Ein aktueller von Sybille Krämer herausgegebener Sammelband beleuchtet die Bedeutung der Computertechnik-Pionierin Ada Lovelace. Bettina Schabschneider hat den Band einer detaillierten Lektüre unterzogen und für die MEDIENIMPULSE rezensiert …

  13. 17 CFR 2.4 - Employee Recreation Association's use of Commission seal.

    Science.gov (United States)

    2010-04-01

    ... imprint upon sport apparel (e.g., hats, clothing, accessories, etc.) and novelty items (e.g., office mugs... fundraising goals and/or in conjunction with its sports, social or similar events. [72 FR 29247, May 25, 2007] ...

  14. Virial expansion for almost diagonal random matrices

    Science.gov (United States)

    Yevtushenko, Oleg; Kravtsov, Vladimir E.

    2003-08-01

    Energy level statistics of Hermitian random matrices hat H with Gaussian independent random entries Higeqj is studied for a generic ensemble of almost diagonal random matrices with langle|Hii|2rangle ~ 1 and langle|Hi\

  15. Netzformen und VDE-Bestimmungen

    Science.gov (United States)

    Bernstein, Herbert

    Der Verband Deutscher Elektrotechniker (VDE) hat eine Reihe von Vorschriften ausgearbeitet, die dem Schutz von Leben und Sachen beim Umgang mit elektrischer Energie dienen. Besonders wichtig sind die in den VDE-Bestimmungen 0100 und 0411 festgelegten Vorschriften.

  16. Disease: H01626 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available nclude age, male gender, smoking, hypertension, hyperlipidemia, diabetes mellitus...hat some micro RNAs could be serum markers for early-stage ASO. Vascular disease ... Cigarette smoking

  17. 76 FR 9049 - Notice of Intent To Repatriate Cultural Items: University of Pennsylvania Museum of Archaeology...

    Science.gov (United States)

    2011-02-16

    ... piece, from the root of the red cedar, and is painted with greenish-blue, red, black, and white pigment...). It is a basketry hat, woven of spruce tree roots, which has been painted white. A design representing...

  18. Chemotherapy

    Science.gov (United States)

    ... cause nerve problems and burning, numbness, tingling, or shooting pain in the fingers and toes. Certain types ... more comfortable wearing hats, scarves, or wigs to school or other events. Or, you may look great ...

  19. Cutaneous Cancers in Nigerian Albinos: A Review of 22 Cases

    African Journals Online (AJOL)

    2018-04-20

    Apr 20, 2018 ... this protective pigment in albinos predisposed them to sunburns and subsequent ... The most common of the skin cancers documented among the albinos ..... hats, application of sunscreen creams and always using umbrella ...

  20. Sierra Leone Journal of Biomedical Research 38 Original Article

    African Journals Online (AJOL)

    ). 38 ... Sleeping sickness or Human African Trypanosomiasis (HAT) caused by Trypanosoma brucei .... end of the 1930th produced new social and .... use) resulted in the radical diminishing of the game ..... strains isolated from pigs in Liberia.

  1. Survival Bayesian Estimation of Exponential-Gamma Under Linex Loss Function

    Science.gov (United States)

    Rizki, S. W.; Mara, M. N.; Sulistianingsih, E.

    2017-06-01

    This paper elaborates a research of the cancer patients after receiving a treatment in cencored data using Bayesian estimation under Linex Loss function for Survival Model which is assumed as an exponential distribution. By giving Gamma distribution as prior and likelihood function produces a gamma distribution as posterior distribution. The posterior distribution is used to find estimatior {\\hat{λ }}BL by using Linex approximation. After getting {\\hat{λ }}BL, the estimators of hazard function {\\hat{h}}BL and survival function {\\hat{S}}BL can be found. Finally, we compare the result of Maximum Likelihood Estimation (MLE) and Linex approximation to find the best method for this observation by finding smaller MSE. The result shows that MSE of hazard and survival under MLE are 2.91728E-07 and 0.000309004 and by using Bayesian Linex worths 2.8727E-07 and 0.000304131, respectively. It concludes that the Bayesian Linex is better than MLE.

  2. Browse Title Index

    African Journals Online (AJOL)

    Items 201 - 250 of 788 ... Vol 8, No 1 (2000), Development of Education of the Hearing Impaired in Nigeria. ... Vol 15, No 2 (2007), Effectiveness Of Six Thinking Hats Training In ... performance of choking-susceptible university athletes, Abstract.

  3. RADICAL SCAVENGING ACTIVITY OF SOME NATURAL ...

    African Journals Online (AJOL)

    Hydrogen atom transfer (HAT) and one-electron transfer mechanisms have ... In this work, the structural, electronic and molecular properties were ..... modification to tune the electronic and charge transport properties of solar cell materials:.

  4. Dandruff: How to Treat

    Medline Plus

    Full Text Available ... potential to make your scalp more sensitive to sunlight. If you use this type of dandruff shampoo, it’s important to protect your scalp from the sun by wearing a hat when outdoors and seeking ...

  5. Die Welt als Puppenhaus. Die verzauberten Filme des Wes Anderson als Retrospektive im Kino Xenix

    OpenAIRE

    Binotto, Johannes

    2012-01-01

    Nur gerade sieben Filme hat der Regisseur und Autor Wes Anderson bisher gemacht, damit aber ein einzigartiges Œuvre geschaffen. Das Xenix zeigt diese melancholischen und verspielten Kunstwerke, zusammen mit Filmen, die als Inspiration dienten.

  6. Pesticide knowledge, practice and attitude and how it affects the ...

    African Journals Online (AJOL)

    2014-06-02

    scale farmers in Uganda: a cross-sectional ... protective equipment (PPE (e.g. mask, boots, gloves, long sleeved shirt, overalls, hat)) ..... What do you wear doing pesticide spraying (PPE)?. Ordinary clothing. 229 (73) 105 (70).

  7. Resonance April Cover Pg TP

    Indian Academy of Sciences (India)

    Admin

    word possibly having its origin in Sanskrit). W hat is ... History and Some Perspectives on Intermolecular Forces. E Arunan. Keywords van der Waals forces, hydrogen bonding. ... A tom s have rem ained a dom ain of physics, rather than.

  8. Sequence Classification: 889373 [

    Lifescience Database Archive (English)

    Full Text Available hat stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis; Tsc3p || http://www.ncbi.nlm.nih.gov/protein/14270689 ...

  9. Die Landschaft in der Geschichte, in der Kultur, in der Kunts und in der Stadtplanung: theoretische Annahmen und Erfahrungen

    Directory of Open Access Journals (Sweden)

    Mario Coletta

    2013-01-01

    Full Text Available Das vorgeschlagene Thema hat das Ziel, dem Konzept der Landschaft eine neue Definition zu geben. Sie soll nicht nur als Umhuellung des staedtischen und laendlichen Territoriums gesehen werden, das besiedelt und produktiv ist, zivilisiet und natuerlich belassen, sondern wie ein lebender Koerper, wenn auch nicht bei bester Gesundheit, der trotz seines Altes noch den vielen Veraenderungen standhaelt. Veraenderungen durch Naturkatatrophen herforgerufen, und besonders durch die vielen Wunden die das Werk der Menschen ihm zugefuegt hat. Als lebendes Wesen leidet die Landschaft und freut sich in guten Zeiten, kleidert sich lieber arm, aber schicklich, als reich und anmassend: Zeuge guter und schlechter Haushaltsfuehrung, jedoch Erbe einer Geschichte die sie erhebt, die Geschichte, Literatur, Ausdruecke der Kunts, kreative Planung beseelt hat. All das ist zusammengefasst in dem Wort "Kultur", die es verdient hat, erworben zu werden, vertieft und den naeschsten Generationen weitergegeben, moeglicherweise noch bereichert von dem, das die heutige Kultur ausarbeiten kann, auch auf dem Weg der Stadtplanung.

  10. Understanding and Managing Head Lice | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... to share hats, combs, or brushes with others. Policies regarding school attendance for children with head lice vary. Sources: National Library of Medicine, Centers for Disease Control and Prevention, ...

  11. Human African trypanosomiasis in the Democratic Republic of the Congo: disease distribution and risk.

    Science.gov (United States)

    Lumbala, Crispin; Simarro, Pere P; Cecchi, Giuliano; Paone, Massimo; Franco, José R; Kande Betu Ku Mesu, Victor; Makabuza, Jacquies; Diarra, Abdoulaye; Chansy, Shampa; Priotto, Gerardo; Mattioli, Raffaele C; Jannin, Jean G

    2015-06-06

    For the past three decades, the Democratic Republic of the Congo (DRC) has been the country reporting the highest number of cases of human African trypanosomiasis (HAT). In 2012, DRC continued to bear the heaviest burden of gambiense HAT, accounting for 84 % of all cases reported at the continental level (i.e., 5,968/7,106). This paper reviews the status of sleeping sickness in DRC between 2000 and 2012, with a focus on spatio-temporal patterns. Epidemiological trends at the national and provincial level are presented. The number of HAT cases reported yearly from DRC decreased by 65 % from 2000 to 2012, i.e., from 16,951 to 5,968. At the provincial level a more complex picture emerges. Whilst HAT control in the Equateur province has had a spectacular impact on the number of cases (97 % reduction), the disease has proved more difficult to tackle in other provinces, most notably in Bandundu and Kasai, where, despite substantial progress, HAT remains entrenched. HAT prevalence presents its highest values in the northern part of the Province Orientale, where a number of constraints hinder surveillance and control. Significant coordinated efforts by the National Sleeping Sickness Control Programme and the World Health Organization in data collection, reporting, management and mapping, culminating in the Atlas of HAT, have enabled HAT distribution and risk in DRC to be known with more accuracy than ever before. Over 18,000 locations of epidemiological interest have been geo-referenced (average accuracy ≈ 1.7 km), corresponding to 93.6 % of reported cases (period 2000-2012). The population at risk of contracting sleeping sickness has been calculated for two five-year periods (2003-2007 and 2008-2012), resulting in estimates of 33 and 37 million people respectively. The progressive decrease in HAT cases reported since 2000 in DRC is likely to reflect a real decline in disease incidence. If this result is to be sustained, and if further progress is to be made

  12. Subunits of ADA-two-A-containing (ATAC) or Spt-Ada-Gcn5-acetyltrasferase (SAGA) Coactivator Complexes Enhance the Acetyltransferase Activity of GCN5.

    Science.gov (United States)

    Riss, Anne; Scheer, Elisabeth; Joint, Mathilde; Trowitzsch, Simon; Berger, Imre; Tora, László

    2015-11-27

    Histone acetyl transferases (HATs) play a crucial role in eukaryotes by regulating chromatin architecture and locus specific transcription. GCN5 (KAT2A) is a member of the GNAT (Gcn5-related N-acetyltransferase) family of HATs. In metazoans this enzyme is found in two functionally distinct coactivator complexes, SAGA (Spt Ada Gcn5 acetyltransferase) and ATAC (Ada Two A-containing). These two multiprotein complexes comprise complex-specific and shared subunits, which are organized in functional modules. The HAT module of ATAC is composed of GCN5, ADA2a, ADA3, and SGF29, whereas in the SAGA HAT module ADA2b is present instead of ADA2a. To better understand how the activity of human (h) hGCN5 is regulated in the two related, but different, HAT complexes we carried out in vitro HAT assays. We compared the activity of hGCN5 alone with its activity when it was part of purified recombinant hATAC or hSAGA HAT modules or endogenous hATAC or hSAGA complexes using histone tail peptides and full-length histones as substrates. We demonstrated that the subunit environment of the HAT complexes into which GCN5 incorporates determines the enhancement of GCN5 activity. On histone peptides we show that all the tested GCN5-containing complexes acetylate mainly histone H3K14. Our results suggest a stronger influence of ADA2b as compared with ADA2a on the activity of GCN5. However, the lysine acetylation specificity of GCN5 on histone tails or full-length histones was not changed when incorporated in the HAT modules of ATAC or SAGA complexes. Our results thus demonstrate that the catalytic activity of GCN5 is stimulated by subunits of the ADA2a- or ADA2b-containing HAT modules and is further increased by incorporation of the distinct HAT modules in the ATAC or SAGA holo-complexes. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  13. Single multivalent vaccination boosted by trickle larval infection confers protection against experimental lymphatic filariasis

    Science.gov (United States)

    Joseph, SK; Ramaswamy, K

    2013-01-01

    The multivalent vaccine BmHAT, consisting of the Brugia malayi infective larval (L3) antigens heat shock protein12.6 (HSP12.6), abundant larval transcript-2 (ALT-2) and tetraspanin large extra cellular loop (TSP-LEL), was shown to be protective in rodent models from our laboratory. We hypothesize that since these antigens were identified using protective antibodies from immune endemic normal individuals, the multivalent vaccine can be augmented by natural L3 infections providing protection to the vaccinated host. This hypothesis was tested using single dose of DNA and Protein or Protein alone of the BmHAT vaccination in gerbils followed by live trickle L3 infection as booster dose. Vaccine-induced protection in gerbils was determined by worm establishment, micropore chamber assay and by antibody dependant cell cytotoxicity (ADCC) assay. Results were compared with the traditional prime-boost vaccination regimen. Gerbils vaccinated with BmHAT and boosted with L3 trickle infection were protected 51% (BmHAT DNA-Protein) and 48% (BmHAT Protein) respectively. BmHAT vaccination plus L3 trickle booster generated significant titer of antigen-specific IgG antibodies comparable to the traditional prime boost vaccination approach. BmHAT vaccination plus L3 trickle booster also generated antigen-specific cells in the spleen of vaccinated animals and these cells secreted predominantly IFN-γ and IL-4 in response to the vaccine antigens. These studies thus show that single dose of BmHAT multivalent vaccination followed by L3 trickle booster infection can confer significant protection against lymphatic filariasis. PMID:23735679

  14. Socio-economic and cultural determinants of human african trypanosomiasis at the Kenya - Uganda transboundary.

    Directory of Open Access Journals (Sweden)

    Jane Jemeli Rutto

    Full Text Available BACKGROUND: Kenya and Uganda have reported different Human African Trypanosomiasis incidences in the past more than three decades, with the latter recording more cases. This cross-sectional study assessed the demographic characteristics, tsetse and trypanosomiasis control practices, socio-economic and cultural risk factors influencing Trypanosoma brucei rhodesiense (T.b.r. infection in Teso and Busia Districts, Western Kenya and Tororo and Busia Districts, Southeast Uganda. A conceptual framework was postulated to explain interactions of various socio-economic, cultural and tsetse control factors that predispose individuals and populations to HAT. METHODS: A cross-sectional household survey was conducted between April and October 2008. Four administrative districts reporting T.b.r and lying adjacent to each other at the international boundary of Kenya and Uganda were purposely selected. Household data collection was carried out in two villages that had experienced HAT and one other village that had no reported HAT case from 1977 to 2008 in each district. A structured questionnaire was administered to 384 randomly selected household heads or their representatives in each country. The percent of respondents giving a specific answer was reported. Secondary data was also obtained on socio-economic and political issues in both countries. RESULTS: Inadequate knowledge on the disease cycle and intervention measures contributed considerable barriers to HAT, and more so in Uganda than in Kenya. Gender-associated socio-cultural practices greatly predisposed individuals to HAT. Pesticides-based crop husbandry in the 1970's reportedly reduced vector population while vegetation of coffee and banana's and livestock husbandry directly increased occurrence of HAT. Livestock husbandry practices in the villages were strong predictors of HAT incidence. The residents in Kenya (6.7% applied chemoprophylaxis and chemotherapeutic controls against trypanosomiasis to a

  15. Eine ökonomische Analyse der wissensintensiven Dienstleistung Coaching

    OpenAIRE

    Gross, Peter-Paul

    2013-01-01

    Über die letzten 20 Jahre hat sich Coaching zu einer der gefragtesten Personalentwicklungsdienstleistungen entwickelt. Aus dem Sport kommend, wurde Coaching zunächst als exklusive Maßnahme für Top-Führungskräfte konzipiert. In den 1980er Jahren wurden erste Angebote von Top-Executive-Coaching, orientiert an amerikanischen Vorbildern, in Deutschland angeboten. Bis heute hat Coaching darauf einen unglaublichen Boom erlebt. Da ...

  16. 15-Deoxy-{Delta}{sup 12,14}-prostaglandin J{sub 2} impairs the functions of histone acetyltransferases through their insolubilization in cells

    Energy Technology Data Exchange (ETDEWEB)

    Hironaka, Asako [Department of Biochemistry, Nara Medical University, Shijo-Cho 840, Kashihara, Nara 634-8521 (Japan); Morisugi, Toshiaki; Kawakami, Tetsuji [Department of Oral and Maxillofacial Surgery, Nara Medical University, Shijo-Cho 840, Kashihara, Nara 634-8521 (Japan); Miyagi, Ikuko [Laboratory of Biometabolic Chemistry, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara-Cho, Okinawa 903-0215 (Japan); Tanaka, Yasuharu, E-mail: yatanaka@med.u-ryukyu.ac.jp [Laboratory of Biometabolic Chemistry, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara-Cho, Okinawa 903-0215 (Japan)

    2009-12-11

    The cyclopentenonic prostaglandin 15-deoxy-{Delta}{sup 12,14}-PG J{sub 2} (15d-PGJ{sub 2}) is a metabolite derived from PGD{sub 2}. Although 15d-PGJ{sub 2} has been demonstrated to be a potent ligand for peroxisome proliferator activated receptor {gamma} (PPAR{gamma}), the functions are not fully understood. In order to examine the effect of 15d-PGJ{sub 2} on histone acetyltransferases (HATs), several lines of cell including mouse embryonic fibroblast (MEF) cells were exposed to 15d-PGJ{sub 2}. Three types of HAT, p300, CREB-binding protein (CBP), and p300/CBP-associated factor (PCAF), selectively disappeared from the soluble fraction in time- and dose-dependent manners. Inversely, HATs in the insoluble fraction increased, suggesting their conformational changes. The decrease in the soluble form of HATs resulted in the attenuation of NF-{kappa}B-, p53-, and heat shock factor-dependent reporter gene expressions, implying that the insoluble HATs are inactive. The resultant insoluble PCAF and p300 seemed to be digested by proteasome, because proteasome inhibitors caused the accumulation of insoluble HATs. Taken together, these results indicate that 15d-PGJ{sub 2} attenuates some gene expressions that require HATs. This inhibitory action of 15d-PGJ{sub 2} on the function of HATs was independent of PPAR{gamma}, because PPAR{gamma} agonists could not mimick 15d-PGJ{sub 2} and PPAR{gamma} antagonists did not inhibit 15d-PGJ{sub 2}.

  17. Enhancements to PCRSM.

    Science.gov (United States)

    1991-03-01

    the A parameters; yhatf, to calculate the y-hat statistics; ssrf, to calculate the uncorrected SSR; sstof, to calculate the uncorrected SSTO ; matmulmm...DEGREES OF FREEDOM * int sstocdf, ssrcdf, ssecdf; float ssr, ssto , sse; /* SUM OF SQUARES * float ssrc, sstoc, ssec; float insr, insto, inse; float...Y-HAT STATSISTICS * yhatf(x,beta,stats,n,n); /* CALCULATE UNCORRECTED SSR * ssrf(beta, x, y, mn, n, ss); ssr = ss[l][l]; /* CALCULATE UNCORRECTED SSTO

  18. 3D-Druckverfahren für kompakte und mechanisch stabile Formkörper

    OpenAIRE

    Kottlorz, Christoph

    2014-01-01

    Der Computer hat die Strategie der Entwicklung neuer Produkte revolutioniert. Mit dem CAD-Verfahren (computer-aided design), können heute virtuelle Modelle in nahezu uneingeschränkter Formvielfalt entworfen werden. Produkteigenschaften müssen aber noch immer an realen Formkörpern evaluiert werden. Dies hat einen Bedarf an schnellen Formgebungsmethoden erzeugt, mit denen Prototypen hergestellt werden können (RP: rapid prototyping). Diese Arbeit befasste sich mit dem generativen Fertigu...

  19. China - Nicht alles Gold, was glänzt!

    OpenAIRE

    Kolle, Christian

    2008-01-01

    Anlässlich der XXIX. olympischen Sommerspiele in Peking beschäftigt sich die August-Ausgabe der Recherche Spezial mit den zahlreichen sozialwissenschaftlichen Aspekten und Facetten, die der bevölkerungsreichste Staat der Erde zu bieten hat. Der rasante Aufstieg zur Wirtschaftsmacht innerhalb von nur drei Jahrzehnten hat dem chinesischen Staat zwar internationale Anerkennung gepaart mit ängstlicher Ehrfurcht beschert, ist aber gleichzeitig auch Ursprung einer Reihe von sozialen Problemen i...

  20. THE CLINICAL, FUNCTIONAL AND BIOMECHANICAL PRESENTATION OF PATIENTS WITH SYMPTOMATIC HIP ABDUCTOR TENDON TEARS.

    Science.gov (United States)

    Ebert, Jay R; Retheesh, Theertha; Mutreja, Rinky; Janes, Gregory C

    2016-10-01

    Hip abductor tendon (HAT) tearing is commonly implicated in greater trochanteric pain syndrome (GTPS), though limited information exists on the disability associated with this condition and specific presentation of these patients. To describe the clinical, functional and biomechanical presentation of patients with symptomatic HAT tears. Secondary purposes were to investigate the association between these clinical and functional measures, and to compare the pain and disability reported by HAT tear patients to those with end-stage hip osteoarthritis (OA). Prospective case series. One hundred forty-nine consecutive patients with symptomatic HAT tears were evaluated using the Harris (HHS) and Oxford (OHS) Hip Scores, SF-12, an additional series of 10 questions more pertinent to those with lateral hip pain, active hip range of motion (ROM), maximal isometric hip abduction strength, six-minute walk capacity and 30-second single limb stance (SLS) test. The presence of a Trendelenburg sign and pelvis-on-femur (POF) angle were determined via 2D video analysis. An age matched comparative sample of patients with end-stage hip OA was recruited for comparison of all patient-reported outcome scores. Independent t-tests investigated group and limb differences, while analysis of variance evaluated pain changes during the functional tests. Pearson's correlation coefficients investigated the correlation between clinical measures in the HAT tear group. No differences existed in patient demographics and patient-reported outcome scores between HAT tear and hip OA cohorts, apart from significantly worse SF-12 mental subscale scores (p = 0.032) in the HAT tear group. Patients with HAT tears demonstrated significantly lower (p presentation of these patients. Level 3 case-controlled study, with matched comparison.

  1. Einkaufen unter veränderten Vorzeichen: Ausgewählte Erfolgsfaktoren des "Konsortial-Benchmarking Einkauf 2010"

    OpenAIRE

    Kreysa, Jennifer

    2010-01-01

    Die Finanz- und Wirtschaftskrise hat für viele Unternehmen nicht nur das externe Einkaufsumfeld, sondern auch die internen Anforderungen an den Einkauf stark verändert. Für das diesjährige Konsortial-Benchmarking im Einkauf hat die Abteilung Technologiemanagement des Fraunhofer IPT gemeinsam mit einem hochkarätigen Industriekonsortium erneut die Vorgehensweisen und Ansätze besonders erfolgreicher Einkaufsabteilungen analysiert. Die Ergebnisse des Projekts geben nicht nur Aufschluss darüber, w...

  2. Zur Standardisierung der DSH-Prüfungen: Bestandsaufnahme und Perspektiven des Online-Angebotes

    OpenAIRE

    Schneider, Agnieszka

    2010-01-01

    Das Internet ist im 21. Jahrhundert zum wichtigsten Informations- und Kommunikationsmedium geworden und hat auch in der Hochschullandschaft einen festen Platz eingenommen. Das Lernen mit und auf Internetplattformen hat sich im universitären Bereich stark etabliert. Auch die Bedeutung von Online-Prüfungen ist infolge der unter dem Schlagwort "Bologna-Prozess" bekannten Umstrukturierungen stark angestiegen. Da im Bereich der deutschen Sprachprüfung für den Hochschulzugang (DSH) bisher nur wenig...

  3. Single multivalent vaccination boosted by trickle larval infection confers protection against experimental lymphatic filariasis.

    Science.gov (United States)

    Joseph, S K; Ramaswamy, K

    2013-07-18

    The multivalent vaccine BmHAT, consisting of the Brugia malayi infective larval (L3) antigens heat shock protein12.6 (HSP12.6), abundant larval transcript-2 (ALT-2) and tetraspanin large extra cellular loop (TSP-LEL), was shown to be protective in rodent models from our laboratory. We hypothesize that since these antigens were identified using protective antibodies from immune endemic normal individuals, the multivalent vaccine can be augmented by natural L3 infections providing protection to the vaccinated host. This hypothesis was tested using single dose of DNA and protein or protein alone of the BmHAT vaccination in gerbils followed by live trickle L3 infection as booster dose. Vaccine-induced protection in gerbils was determined by worm establishment, micropore chamber assay and by antibody dependant cell cytotoxicity (ADCC) assay. Results were compared with the traditional prime-boost vaccination regimen. Gerbils vaccinated with BmHAT and boosted with L3 trickle infection were protected 51% (BmHAT DNA-protein) and 48% (BmHAT protein) respectively. BmHAT vaccination plus L3 trickle booster generated significant titer of antigen-specific IgG antibodies comparable to the traditional prime boost vaccination approach. BmHAT vaccination plus L3 trickle booster also generated antigen-specific cells in the spleen of vaccinated animals and these cells secreted predominantly IFN-γ and IL-4 in response to the vaccine antigens. These studies thus show that single dose of BmHAT multivalent vaccination followed by L3 trickle booster infection can confer significant protection against lymphatic filariasis. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. Wilhelm Wundts Nachlass. Eine Übersicht.

    OpenAIRE

    Fahrenberg, Jochen

    2016-01-01

    Wilhelm Wundts Publikationen bilden wahrscheinlich das umfangreichste, zweifellos aber das vielseitigste Werk eines Psychologen. Auch sein wissenschaftlicher Nachlass an Manuskripten, Exzerpten und Korrespondenz hat einen ungewöhnlichen Umfang. Während es an guten Digitalisaten seiner Publikationen noch mangelt, ist der allergrößte Teil des Wundt-Nachlasses seit Ende 2015 dokumentiert und digitalisiert (Meyer, 2015). Die Übersicht hat 12 Abschnitte: (1) Wundts Publikationen, Bibliographie...

  5. Marktkonstitution und Regulierung der unabhängigen Film- und Fernsehproduktion : Staat, Verbände und Gewerkschaften im deutsch-britischen Vergleich

    OpenAIRE

    Elbing, Sabine; Voelzkow, Helmut

    2006-01-01

    "In einem internationalen Vergleich von Deutschland und Großbritannien wird untersucht, welche Beiträge die staatliche Politik und die Wirtschafts- und Sozialpartner (Wirtschafts- und Arbeitgeberverbände sowie Gewerkschaften) zur Förderung der unabhängigen Film- und Fernsehproduktion leisten. Es wird gezeigt, dass die britische Medienpolitik die Position der unabhängigen Film- und Fernsehproduktion gegenüber den Fernsehsendern gestärkt hat. In Deutschland hat die Medienpolitik darauf verzicht...

  6. Concurrent Hepatic Artery and Portal Vein Thrombosis after Orthotopic Liver Transplantation with Preserved Allografts

    Directory of Open Access Journals (Sweden)

    Arshad Khan

    2014-01-01

    Full Text Available In contrast to early HAT, late HAT has an insidious clinical presentation. Nevertheless, biliary and vascular reconstructions in this late setting are unlikely to improve outcome. Patent portal flow makes an important contribution to the viability of liver in case of late HAT while the allograft reconstitutes intrahepatic arterial flow through neovascularization. Concurrent HAT with PVT without immediate graft necrosis is extremely rare, and allograft and patient survival are seemingly impossible without retransplantation. In fact, hepatopetal arterial and portal venous neovascularization are known albeit obscure phenomena that can preserve posttransplant hepatic function under the extenuating circumstances of complete interruption of blood flow to the graft. We describe two such cases that developed combined HAT and PVT more than six months after OLT with perfect preservation of graft function. The survival of allografts in our cases was due to extensive hepatopetal arterial and portal venous collateralization. Simultaneous HAT and PVT after OLT are rare events and almost uniformly fatal, if they occur early. Due to paucity of such cases, however, underlying mechanisms and etiology remain elusive, and despite radiological diagnosis of these complications, there is no way to predict these events in the wake of stable graft function.

  7. “SALOME gave my dignity back”: The role of randomized heroin trials in transforming lives in the Downtown Eastside of Vancouver, Canada

    Directory of Open Access Journals (Sweden)

    Ehsan Jozaghi

    2014-03-01

    Full Text Available Although numerous studies on heroin-assisted treatment (HAT have been published in leading international journals, little attention has been given to HAT's clients, their stories, and what constitutes the most influential factor in the treatment process. The present study investigates the role of HAT in transforming the lives of injection drug users (IDUs in Vancouver, Canada. This study is qualitative focusing on 16 in-depth interviews with patients from the randomized trials of HAT. Interviews were transcribed verbatim and analyzed thematically using NVivo 10 software. The findings revealed a positive change in many respects: the randomized trials reduce criminal activity, sex work, and illicit drug use. In addition, the trials improved the health and social functioning of its clients, with some participants acquiring work or volunteer positions. Many of the participants have been able to reconnect with their family members, which was not possible before the program. Furthermore, the relationship between the staff and patients at the project appears to have transformed the behavior of participants. Attending HAT in Vancouver has been particularly effective in creating a unique microenvironment where IDUs who have attended HAT have been able to form a collective identity advocating for their rights. The result of this research points to the need for continuation of the project beyond the current study, leading toward a permanent program.

  8. Involvement of H2O2 in fluazifop-P-butyl-induced cell death in bristly starbur seedlings.

    Science.gov (United States)

    Luo, Xiaoyong; Liu, Zhihang; Sunohara, Yukari; Matsumoto, Hiroshi; Li, Pingliang

    2017-11-01

    In order to understand the action mechanism of fluazifop-P-butyl (FB) in bristly starbur (Acanthospermum hispidum D.C.), a susceptible plant, the role of active oxygen species (ROS) in herbicide-induced cell death in shoots was investigated. FB-induced phytotoxicity was not reduced by the antioxidants, 1,4-diazabicyclooctane (dabaco), sodium azide, l-tryptophan, d-tryptophan, hydroquinone and dimethyl pyridine N-oxide (DMPO). The activities of superoxide dismutase (SOD) and catalase (CAT), in bristly starbur seedlings were significantly increased by FB at 12 HAT and 24 HAT, while ascorbate peroxidase (APX) and glutathione reductase (GR) activities increased only at 12 HAT. The contents of H 2 O 2 in FB-treated bristly starbur seedlings were significantly higher to that of control between 8 and 24 HAT. According to the analysis of potassium iodide - starch or 3,3-diaminobenzidine, the accumulation of hydrogen peroxide was observed in the apical growing point, stem, petiole and veins of FB-treated bristly starbur seedlings at 24 HAT. The cell viability of bristly starbur seedlings treated by 10μM FB decreased at 18 HAT. These results suggested that FB-induced cell death in bristly starbur shoots may be caused by ROS (O 2 - and H 2 O 2 ) generation and lipid peroxidation. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. KAM for the non-linear Schroedinger equation

    CERN Document Server

    Eliasson, L H

    2006-01-01

    We consider the $d$-dimensional nonlinear Schr\\"o\\-dinger equation under periodic boundary conditions:-i\\dot u=\\Delta u+V(x)*u+\\ep|u|^2u;\\quad u=u(t,x),\\;x\\in\\T^dwhere $V(x)=\\sum \\hat V(a)e^{i\\sc{a,x}}$ is an analytic function with $\\hat V$ real. (This equation is a popular model for the `real' NLS equation, where instead of the convolution term $V*u$ we have the potential term $Vu$.) For $\\ep=0$ the equation is linear and has time--quasi-periodic solutions $u$,u(t,x)=\\sum_{s\\in \\AA}\\hat u_0(a)e^{i(|a|^2+\\hat V(a))t}e^{i\\sc{a,x}}, \\quad 0<|\\hat u_0(a)|\\le1,where $\\AA$ is any finite subset of $\\Z^d$. We shall treat $\\omega_a=|a|^2+\\hat V(a)$, $a\\in\\AA$, as free parameters in some domain $U\\subset\\R^{\\AA}$. This is a Hamiltonian system in infinite degrees of freedom, degenerate but with external parameters, and we shall describe a KAM-theory which, in particular, will have the following consequence: \\smallskip {\\it If $|\\ep|$ is sufficiently small, then there is a large subset $U'$ of $U$ such that for all $...

  10. KAM for the non-linear Schroedinger equation a short presentation

    CERN Document Server

    Eliasson, H L

    2006-01-01

    We consider the $d$-dimensional nonlinear Schr\\"o\\-dinger equation under periodic boundary conditions:-i\\dot u=\\Delta u+V(x)*u+\\ep \\frac{\\p F}{\\p \\bar u}(x,u,\\bar u) ;\\quad u=u(t,x),\\;x\\in\\T^dwhere $V(x)=\\sum \\hat V(a)e^{i\\sc{a,x}}$ is an analytic function with $\\hat V$ real and $F$ is a real analytic function in $\\Re u$, $\\Im u$ and $x$. (This equation is a popular model for the `real' NLS equation, where instead of the convolution term $V*u$ we have the potential term $Vu$.) For $\\ep=0$ the equation is linear and has time--quasi-periodic solutions $u$,u(t,x)=\\sum_{s\\in \\AA}\\hat u_0(a)e^{i(|a|^2+\\hat V(a))t}e^{i\\sc{a,x}}, \\quad 0<|\\hat u_0(a)|\\le1,where $\\AA$ is any finite subset of $\\Z^d$. We shall treat $\\omega_a=|a|^2+\\hat V(a)$, $a\\in\\AA$, as free parameters in some domain $U\\subset\\R^{\\AA}$. This is a Hamiltonian system in infinite degrees of freedom, degenerate but with external parameters, and we shall describe a KAM-theory which, in particular, will have the following consequence: \\smallskip {\\it ...

  11. Association of adipocyte genes with ASP expression: a microarray analysis of subcutaneous and omental adipose tissue in morbidly obese subjects

    Directory of Open Access Journals (Sweden)

    Lu HuiLing

    2010-01-01

    Full Text Available Abstract Background Prevalence of obesity is increasing to pandemic proportions. However, obese subjects differ in insulin resistance, adipokine production and co-morbidities. Based on fasting plasma analysis, obese subjects were grouped as Low Acylation Stimulating protein (ASP and Triglyceride (TG (LAT vs High ASP and TG (HAT. Subcutaneous (SC and omental (OM adipose tissues (n = 21 were analysed by microarray, and biologic pathways in lipid metabolism and inflammation were specifically examined. Methods LAT and HAT groups were matched in age, obesity, insulin, and glucose, and had similar expression of insulin-related genes (InsR, IRS-1. ASP related genes tended to be increased in the HAT group and were correlated (factor B, adipsin, complement C3, p Results HAT adipose tissue demonstrated increased lipid related genes for storage (CD36, DGAT1, DGAT2, SCD1, FASN, and LPL, lipolysis (HSL, CES1, perilipin, fatty acid binding proteins (FABP1, FABP3 and adipocyte differentiation markers (CEBPα, CEBPβ, PPARγ. By contrast, oxidation related genes were decreased (AMPK, UCP1, CPT1, FABP7. HAT subjects had increased anti-inflammatory genes TGFB1, TIMP1, TIMP3, and TIMP4 while proinflammatory PIG7 and MMP2 were also significantly increased; all genes, p Conclusion Taken together, the profile of C5L2 receptor, ASP gene expression and metabolic factors in adipose tissue from morbidly obese HAT subjects suggests a compensatory response associated with the increased plasma ASP and TG.

  12. Heparin-associated thrombocytopenia: antibody binding specificity to platelet antigens.

    Science.gov (United States)

    Lynch, D M; Howe, S E

    1985-11-01

    Sera from four patients with heparin-associated thrombocytopenia (HAT) were evaluated by a quantitative enzyme-linked immunosorbent assay (ELISA) to detect heparin-dependent serum platelet-bindable immunoglobulin (S-PBIg) and by Western blotting and immunoprecipitation to investigate the specificity of the antibody binding. All HAT sera showed mildly increased S-PBIg (mean, 7.8 fg per platelet; normal, less than 6.0 fg per platelet) to intact target platelets in the ELISA, which was markedly increased in the presence of heparin (mean, 20.9 fg per platelet). This increase was 20-fold greater than normal control sera, which showed a mean differential increase of only 0.5 fg per platelet. Immunoglobulin binding specificity to platelet antigens was investigated using sodium dodecyl sulfate-polyacrylamide gel electrophoresis of platelet lysate with transfer of the platelet fractions onto nitrocellulose strips (Western blotting) and subsequent immunoassay using HAT and normal sera. In the presence of heparin, the four HAT patients demonstrated increased binding of immunoglobulin to platelet antigens of apparent molecular weights of 180, 124, and 82 kd. Radiolabeled heparin when incubated with HAT sera, normal sera, or albumin blanks bound to platelet proteins of the same apparent molecular weights. These observations are consistent with current hypotheses suggesting that HAT antibody is directed to heparin-platelet complexes or, alternatively, that heparin induces conformational change of antigenic sites on the platelet membrane.

  13. A Statistical Study of Serum Cholesterol Level by Gender and Race.

    Science.gov (United States)

    Tharu, Bhikhari Prasad; Tsokos, Chris P

    2017-07-25

    Cholesterol level (CL) is growing concerned as health issue in human health since it is considered one of the causes in heart diseases. A study of cholesterol level can provide insight about its nature and characteristics. A cross-sectional study. National Health and Nutrition Examination Survey (NHANS) II was conducted on a probability sample of approximately 28,000 persons in the USA and cholesterol level is obtained from laboratory results. Samples were selected so that certain population groups thought to be at high risk of malnutrition. Study included 11,864 persons for CL cases with 9,602 males and 2,262 females with races: whites, blacks, and others. Non-parametric statistical tests and goodness of fit test have been used to identify probability distributions. The study concludes that the cholesterol level exhibits significant racial and gender differences in terms of probability distributions. The study has concluded that white people are relatively higher at risk than black people to have risk line and high risk cholesterol. The study clearly indicates that black males normally have higher cholesterol. Females have lower variation in cholesterol than males. There exists gender and racial discrepancies in cholesterol which has been identified as lognormal and gamma probability distributions. White individuals seem to be at a higher risk of having high risk cholesterol level than blacks. Females tend to have higher variation in cholesterol level than males.

  14. Topological relics of symmetry breaking: winding numbers and scaling tilts from random vortex–antivortex pairs

    International Nuclear Information System (INIS)

    Zurek, W H

    2013-01-01

    I show that random distributions of vortex–antivortex pairs (rather than of individual vortices) lead to scaling of typical winding numbers W trapped inside a loop of circumference C with the square root of that circumference, W∼√C, when the expected winding numbers are large, |W| ≫ 1. Such scaling is consistent with the Kibble–Zurek mechanism (KZM), with 〈W 2 〉 inversely proportional to ξ-hat , the typical size of the domain that can break symmetry in unison. (The dependence of ξ-hat on quench rate is predicted by KZM from critical exponents of the phase transition.) Thus, according to KZM, the dispersion √ 2 > scales as √(C/ ξ-hat ) for large W. By contrast, a distribution of individual vortices with randomly assigned topological charges would result in the dispersion scaling with the square root of the area inside C (i.e., √ 2 > ∼ C). Scaling of the dispersion of W as well as of the probability of detection of non-zero W with C and ξ-hat can be also studied for loops so small that non-zero windings are rare. In this case I show that dispersion varies not as 1/√( ξ-hat ), but as 1/ ξ-hat , which results in a doubling of the scaling of dispersion with the quench rate when compared to the large |W| regime. Moreover, the probability of trapping of non-zero W becomes approximately equal to 〈W 2 〉, and scales as 1/ ξ-hat 2 . This quadruples—as compared with √ 2 > ≃ √C/ξ-circumflex valid for large W—the exponent in the power law dependence of the frequency of trapping of |W| = 1 on ξ-hat when the probability of |W| > 1 is negligible. This change of the power law exponent by a factor of four—from 1/√( ξ-hat ) for the dispersion of large W to 1/ ξ-hat 2 for the frequency of non-zero W when |W| > 1 is negligibly rare—is of paramount importance for experimental tests of KZM. (paper)

  15. The socio-economic burden of human African trypanosomiasis and the coping strategies of households in the South Western Kenya foci.

    Directory of Open Access Journals (Sweden)

    Salome A Bukachi

    2017-10-01

    Full Text Available Human African Trypanosomiasis (HAT, a disease caused by protozoan parasites transmitted by tsetse flies, is an important neglected tropical disease endemic in remote regions of sub-Saharan Africa. Although the determination of the burden of HAT has been based on incidence, mortality and morbidity rates, the true burden of HAT goes beyond these metrics. This study sought to establish the socio-economic burden that households with HAT faced and the coping strategies they employed to deal with the increased burden.A mixed methods approach was used and data were obtained through: review of hospital records; structured interviews (152; key informant interviews (11; case narratives (12 and focus group discussions (15 with participants drawn from sleeping sickness patients in the south western HAT foci in Kenya. Quantitative data were analysed using descriptive statistics while qualitative data was analysed based on emerging themes.Socio-economic impacts included, disruption of daily activities, food insecurity, neglect of homestead, poor academic performance/school drop-outs and death. Delayed diagnosis of HAT caused 93% of the affected households to experience an increase in financial expenditure (ranging from US$ 60-170 in seeking treatment. Out of these, 81.5% experienced difficulties in raising money for treatment resorting to various ways of raising it. The coping strategies employed to deal with the increased financial expenditure included: sale of agricultural produce (64%; seeking assistance from family and friends (54%; sale/lease of family assets (22%; seeking credit (22% and use of personal savings (17%.Coping strategies outlined in this study impacted negatively on the affected households leading to further food insecurity and impoverishment. Calculation of the true burden of disease needs to go beyond incidence, mortality and morbidity rates to capture socio-economic variables entailed in seeking treatment and coping strategies of HAT

  16. Novel insect leaf-mining after the end-Cretaceous extinction and the demise of cretaceous leaf miners, Great Plains, USA.

    Directory of Open Access Journals (Sweden)

    Michael P Donovan

    Full Text Available Plant and associated insect-damage diversity in the western U.S.A. decreased significantly at the Cretaceous-Paleogene (K-Pg boundary and remained low until the late Paleocene. However, the Mexican Hat locality (ca. 65 Ma in southeastern Montana, with a typical, low-diversity flora, uniquely exhibits high damage diversity on nearly all its host plants, when compared to all known local and regional early Paleocene sites. The same plant species show minimal damage elsewhere during the early Paleocene. We asked whether the high insect damage diversity at Mexican Hat was more likely related to the survival of Cretaceous insects from refugia or to an influx of novel Paleocene taxa. We compared damage on 1073 leaf fossils from Mexican Hat to over 9000 terminal Cretaceous leaf fossils from the Hell Creek Formation of nearby southwestern North Dakota and to over 9000 Paleocene leaf fossils from the Fort Union Formation in North Dakota, Montana, and Wyoming. We described the entire insect-feeding ichnofauna at Mexican Hat and focused our analysis on leaf mines because they are typically host-specialized and preserve a number of diagnostic morphological characters. Nine mine damage types attributable to three of the four orders of leaf-mining insects are found at Mexican Hat, six of them so far unique to the site. We found no evidence linking any of the diverse Hell Creek mines with those found at Mexican Hat, nor for the survival of any Cretaceous leaf miners over the K-Pg boundary regionally, even on well-sampled, surviving plant families. Overall, our results strongly relate the high damage diversity on the depauperate Mexican Hat flora to an influx of novel insect herbivores during the early Paleocene, possibly caused by a transient warming event and range expansion, and indicate drastic extinction rather than survivorship of Cretaceous insect taxa from refugia.

  17. Novel insect leaf-mining after the end-Cretaceous extinction and the demise of cretaceous leaf miners, Great Plains, USA.

    Science.gov (United States)

    Donovan, Michael P; Wilf, Peter; Labandeira, Conrad C; Johnson, Kirk R; Peppe, Daniel J

    2014-01-01

    Plant and associated insect-damage diversity in the western U.S.A. decreased significantly at the Cretaceous-Paleogene (K-Pg) boundary and remained low until the late Paleocene. However, the Mexican Hat locality (ca. 65 Ma) in southeastern Montana, with a typical, low-diversity flora, uniquely exhibits high damage diversity on nearly all its host plants, when compared to all known local and regional early Paleocene sites. The same plant species show minimal damage elsewhere during the early Paleocene. We asked whether the high insect damage diversity at Mexican Hat was more likely related to the survival of Cretaceous insects from refugia or to an influx of novel Paleocene taxa. We compared damage on 1073 leaf fossils from Mexican Hat to over 9000 terminal Cretaceous leaf fossils from the Hell Creek Formation of nearby southwestern North Dakota and to over 9000 Paleocene leaf fossils from the Fort Union Formation in North Dakota, Montana, and Wyoming. We described the entire insect-feeding ichnofauna at Mexican Hat and focused our analysis on leaf mines because they are typically host-specialized and preserve a number of diagnostic morphological characters. Nine mine damage types attributable to three of the four orders of leaf-mining insects are found at Mexican Hat, six of them so far unique to the site. We found no evidence linking any of the diverse Hell Creek mines with those found at Mexican Hat, nor for the survival of any Cretaceous leaf miners over the K-Pg boundary regionally, even on well-sampled, surviving plant families. Overall, our results strongly relate the high damage diversity on the depauperate Mexican Hat flora to an influx of novel insect herbivores during the early Paleocene, possibly caused by a transient warming event and range expansion, and indicate drastic extinction rather than survivorship of Cretaceous insect taxa from refugia.

  18. Gravitational collapse of conventional polytropic cylinder

    Science.gov (United States)

    Lou, Yu-Qing; Hu, Xu-Yao

    2017-07-01

    In reference to general polytropic and conventional polytropic hydrodynamic cylinders of infinite length with axial uniformity and axisymmetry under self-gravity, the dynamic evolution of central collapsing mass string in free-fall dynamic accretion phase is re-examined in details. We compare the central mass accretion rate and the envelope mass infall rate at small radii. Among others, we correct mistakes and typos of Kawachi & Hanawa (KH hereafter) and in particular prove that their key asymptotic free-fall solution involving polytropic index γ in the two power exponents is erroneous by analytical analyses and numerical tests. The correct free-fall asymptotic solutions at sufficiently small \\hat{r} (the dimensionless independent self-similar variable) scale as {˜ } -|ln \\hat{r}|^{1/2} in contrast to KH's ˜ -|ln \\hat{r}|^{(2-γ )/2} for the reduced bulk radial flow velocity and as {˜ } \\hat{r}^{-1}|ln \\hat{r}|^{-1/2} in contrast to KH's {˜ } \\hat{r}^{-1} |ln \\hat{r}|^{-(2-γ )/2} for the reduced mass density. We offer consistent scenarios for numerical simulation code testing and theoretical study on dynamic filamentary structure formation and evolution as well as pertinent stability properties. Due to unavoidable Jeans instabilities along the cylinder, such collapsing massive filaments or strings can further break up into clumps and segments of various lengths as well as clumps embedded within segments and evolve into chains of gravitationally collapsed objects (such as gaseous planets, brown dwarfs, protostars, white dwarfs, neutron stars, black holes in a wide mass range, globular clusters, dwarf spheroidals, galaxies, galaxy clusters and even larger mass reservoirs etc.) in various astrophysical and cosmological contexts as articulated by Lou & Hu recently. As an example, we present a model scheme for comparing with observations of molecular filaments for forming protostars, brown dwarfs and gaseous planets and so forth.

  19. Humidified micro gas turbines for domestic users: An economic and primary energy savings analysis

    International Nuclear Information System (INIS)

    Montero Carrero, Marina; De Paepe, Ward; Bram, Svend; Musin, Frédéric; Parente, Alessandro; Contino, Francesco

    2016-01-01

    Micro Gas Turbines (mGTs) offer valuable advantages for small-scale Combined Heat and Power (CHP) production compared to reciprocating Internal Combustion Engines (ICEs): lower maintenance costs per kWh_e, cleaner exhaust, lower vibration levels and concentration of the residual heat in a single source (the exhaust gases). Nevertheless, mGTs have lower electrical efficiencies, fact that has prevented them from penetrating in the CHP market. Hot liquid water injection—by means of a saturation tower within the micro Humid Air Turbine (mHAT) cycle—allows both improving the flexibility of heat production and the electrical efficiency of mGTs; two qualities that if enhanced would increase the economic feasibility of the technology. Although the advantages of mHAT technology have been proven from a thermodynamic point of view, its economic performance has not yet been fully investigated. This paper presents a comparison of the economic profitability and the primary energy savings of an mGT, an ICE and an mHAT unit operating in real network conditions. Our aim is to investigate whether the increase in flexibility and electrical efficiency, achieved when transforming an mGT into an mHAT, allows this technology to economically outperform ICEs. Results show that the three units are viable in scenarios with high electricity and low natural gas prices. For the cases in which investment is feasible, the revenues with mHAT are the highest: thanks to their flexibility in heat generation, mHAT units are able to run all year long. On the other hand, the greatest primary energy savings are achieved with ICE units—which have the highest overall efficiencies—while mHAT savings are substantially lower. - Highlights: • We analyse the economics and primary energy savings of an ICE, an mGT and an mHAT. • We consider hourly heat and electricity demand profiles and 25 price scenarios. • Our analysis is carried out for two domestic users with distinctive demand profiles. • If

  20. Estimating the economic and social consequences for patients diagnosed with human African trypanosomiasis in Muchinga, Lusaka and Eastern Provinces of Zambia (2004-2014).

    Science.gov (United States)

    Mwiinde, Allan Mayaba; Simuunza, Martin; Namangala, Boniface; Chama-Chiliba, Chitalu Miriam; Machila, Noreen; Anderson, Neil; Shaw, Alexandra; Welburn, Susan C

    2017-10-10

    Acute human African trypanosomiasis (rHAT) caused by Trypanosoma brucei rhodesiense is associated with high mortality and is fatal if left untreated. Only a few studies have examined the psychological, social and economic impacts of rHAT. In this study, mixed qualitative and quantitative research methods were used to evaluate the socio-economic impacts of rHAT in Mambwe, Rufunsa, Mpika and Chama Districts of Zambia. Individuals diagnosed with rHAT from 2004 to 2014 were traced using hospital records and discussions with communities. Either they, or their families, were interviewed using a structured questionnaire and focus group discussions were conducted with affected communities. The burden of the disease was investigated using disability adjusted life years (DALYs), with and without discounting and age-weighting. The impact of long-term disabilities on the rHAT burden was also investigated. Sixty four cases were identified in the study. The majority were identified in second stage, and the mortality rate was high (12.5%). The total number of DALYs was 285 without discounting or age-weighting. When long-term disabilities were included this estimate increased by 50% to 462. The proportion of years lived with disability (YLD) increased from 6.4% to 37% of the undiscounted and un-age-weighted DALY total. When a more active surveillance method was applied in 2013-2014 the cases identified increased dramatically, suggesting a high level of under-reporting. Similarly, the proportion of females increased substantially, indicating that passive surveillance may be especially failing this group. An average of 4.9 months of productive time was lost per patient as a consequence of infection. The health consequences included pain, amnesia and physical disability. The social consequences included stigma, dropping out of education, loss of friends and self-esteem. Results obtained from focus group discussions revealed misconceptions among community members which could be

  1. Transfection using hydroxyapatite nanoparticles in the inner ear via an intact round window membrane in chinchilla

    Energy Technology Data Exchange (ETDEWEB)

    Wu Xuewen; Ding Dalian [Central South University, Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital (China); Jiang Haiyan [State University of New York at Buffalo, Center for Hearing and Deafness (United States); XingXiaowei [Central South University, Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital (China); Huang, Suping [Central South University, State Key Laboratory of Powder Metallurgy (China); Liu Hong [Central South University, Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital (China); Chen Zhedong [Central South University, State Key Laboratory of Powder Metallurgy (China); Sun Hong, E-mail: shjhaj@vip.163.com [Central South University, Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital (China)

    2012-01-15

    Hydroxyapatite nanoparticles (nHAT) are known to have excellent biocompatibility, and have attracted increasing attention as new candidates of non-viral vectors for gene therapy. In our previous studies, nHAT carrying a therapeutic gene and a reporter gene were successfully transfected into the spiral ganglion neurons in the inner ear of guinea pigs in vivo as well as in the cultured cell lines, although the transfection efficiencies were never higher than 30%. In this study, the surface modification of nHAT with polyethylenimine (PEI) was made (PEI-nHAT, diameter = 73.09 {+-} 27.32 nm) and a recombinant plasmid carrying enhanced green fluorescent protein (EGFP) gene and neurotrophin-3 (NT-3) gene was constructed as pEGFPC2-NT3. The PEI modified nHAT and the recombinant plasmid was then connected to form the nHAT-based vector-gene complex (PEI-nHAT-pEGFPC2-NT3). This complex was then placed onto the intact round window membranes of the chinchillas for inner ear transfection. Auditory brainstem response (ABR) was tested to evaluate auditory function. Green fluorescence of EGFP was observed using confocal microscopy 48 h after administering vector-gene complexes. There was no significant threshold shift in tone burst-evoked ABR at any tested frequency. Abundant, condensed green fluorescence was found in dark cells on both sides of the crista and around the macula of the utricle. Scattered EGFP signals were also detected in vestibular hair cells, some Schwann cells in the cochlear spiral ganglion region, some outer pillar cells in the organ of Corti, and a few cells in the stria vascularis. The density of green fluorescence-marked cells was obviously higher in the vestibular dark cell area than in other areas of the inner ear, suggesting that vestibular dark cells may have the ability to actively engulf the nHAT-based vector-gene complexes. Considering the high transfection efficiency in the vestibular system, PEI-nHAT may be a potential vector for gene therapy of

  2. Valproic acid exposure decreases Cbp/p300 protein expression and histone acetyltransferase activity in P19 cells

    Energy Technology Data Exchange (ETDEWEB)

    Lamparter, Christina L. [Department of Biomedical and Molecular Sciences, Graduate Program in Pharmacology and Toxicology, Queen' s University, Kingston, Ontario K7L 3N6 (Canada); Winn, Louise M., E-mail: winnl@queensu.ca [Department of Biomedical and Molecular Sciences, Graduate Program in Pharmacology and Toxicology, Queen' s University, Kingston, Ontario K7L 3N6 (Canada); School of Environmental Studies, Queen' s University, Kingston, Ontario K7L 3N6 (Canada)

    2016-09-01

    The teratogenicity of the antiepileptic drug valproic acid (VPA) is well established and its inhibition of histone deacetylases (HDAC) is proposed as an initiating factor. Recently, VPA-mediated HDAC inhibition was demonstrated to involve transcriptional downregulation of histone acetyltransferases (HATs), which was proposed to compensate for the increased acetylation resulting from HDAC inhibition. Cbp and p300 are HATs required for embryonic development and deficiencies in either are associated with congenital malformations and embryolethality. The objective of the present study was to characterize Cbp/p300 following VPA exposure in P19 cells. Consistent with previous studies, exposure to 5 mM VPA over 24 h induced a moderate decrease in Cbp/p300 mRNA, which preceded a strong decrease in total cellular protein mediated by ubiquitin-proteasome degradation. Nuclear Cbp/p300 protein was also decreased following VPA exposure, although to a lesser extent. Total cellular and nuclear p300 HAT activity was reduced proportionately to p300 protein levels, however while total cellular HAT activity also decreased, nuclear HAT activity was unaffected. Using the Cbp/p300 HAT inhibitor C646, we demonstrated that HAT inhibition similarly affected many of the same endpoints as VPA, including increased reactive oxygen species and caspase-3 cleavage, the latter of which could be attenuated by pre-treatment with the antioxidant catalase. C646 exposure also decreased NF-κB/p65 protein, which was not due to reduced mRNA and was not attenuated with catalase pre-treatment. This study provides support for an adaptive HAT response following VPA exposure and suggests that reduced Cbp/p300 HAT activity could contribute to VPA-mediated alterations. - Highlights: • VPA exposure in vitro downregulates Cbp/p300 mRNA and induces protein degradation. • Cbp/p300 histone acetyltransferase activity is similarly reduced with VPA exposure. • Inhibition of Cbp/p300 acetyltransferase activity

  3. Alpha-tocopherol transfer factor (aTTF) from rat liver mediates the transfer of d-alpha-[3H]-tocopherol from liposomes to human erythrocyte ghosts and exhibits saturation kinetics

    International Nuclear Information System (INIS)

    Verdon, C.P.; Blumberg, J.B.

    1986-01-01

    aTTF was observed to transfer d-alpha-[ 3 H]-tocopherol ( 3 HaT) from egg lecithin liposomes to human erythrocyte ghosts (EG). aTTF may be associated with the 32,000-35,000 MW alpha-Tocopherol Binding Protein previously described to transfer 3 HaT from liposomes to rat liver microsomes and mitochondria prepared by ammonium sulfate precipitation of rat liver cytosol followed by dialysis against 50 mM TRIS-HCl/1 mM EDTA buffer, pH 7.4. Assay for aTTF activity consisted of incubating liposomal 3 HaT and EG in the presence of aTTF or buffer blank for various time periods at 37 0 C, then counting the resulting radioactivity in washed EG after pelleting by centrifugation. Liposomes were prelabeled-with non-exchangable glycerol-[ 14 C]-trioleate to correct for liposomes adhering to pelleted EG. Greater than 50% of the tritium found with the EG pellet was recovered by HPLC as 3 HaT. aTTF activity increased with increasing liposomal 3 HaT concentration before reaching a plateau. aTTF activity was similarly saturated by increasing EG concentrations. The same assay conditions with buffer blank along resulted in negligible transfer activity

  4. Sufficient condition for a quantum state to be genuinely quantum non-Gaussian

    Science.gov (United States)

    Happ, L.; Efremov, M. A.; Nha, H.; Schleich, W. P.

    2018-02-01

    We show that the expectation value of the operator \\hat{{ \\mathcal O }}\\equiv \\exp (-c{\\hat{x}}2)+\\exp (-c{\\hat{p}}2) defined by the position and momentum operators \\hat{x} and \\hat{p} with a positive parameter c can serve as a tool to identify quantum non-Gaussian states, that is states that cannot be represented as a mixture of Gaussian states. Our condition can be readily tested employing a highly efficient homodyne detection which unlike quantum-state tomography requires the measurements of only two orthogonal quadratures. We demonstrate that our method is even able to detect quantum non-Gaussian states with positive–definite Wigner functions. This situation cannot be addressed in terms of the negativity of the phase-space distribution. Moreover, we demonstrate that our condition can characterize quantum non-Gaussianity for the class of superposition states consisting of a vacuum and integer multiples of four photons under more than 50 % signal attenuation.

  5. Emotion recognition through static faces and moving bodies: a comparison between typically developed adults and individuals with high level of autistic traits.

    Science.gov (United States)

    Actis-Grosso, Rossana; Bossi, Francesco; Ricciardelli, Paola

    2015-01-01

    We investigated whether the type of stimulus (pictures of static faces vs. body motion) contributes differently to the recognition of emotions. The performance (accuracy and response times) of 25 Low Autistic Traits (LAT group) young adults (21 males) and 20 young adults (16 males) with either High Autistic Traits or with High Functioning Autism Spectrum Disorder (HAT group) was compared in the recognition of four emotions (Happiness, Anger, Fear, and Sadness) either shown in static faces or conveyed by moving body patch-light displays (PLDs). Overall, HAT individuals were as accurate as LAT ones in perceiving emotions both with faces and with PLDs. Moreover, they correctly described non-emotional actions depicted by PLDs, indicating that they perceived the motion conveyed by the PLDs per se. For LAT participants, happiness proved to be the easiest emotion to be recognized: in line with previous studies we found a happy face advantage for faces, which for the first time was also found for bodies (happy body advantage). Furthermore, LAT participants recognized sadness better by static faces and fear by PLDs. This advantage for motion kinematics in the recognition of fear was not present in HAT participants, suggesting that (i) emotion recognition is not generally impaired in HAT individuals, (ii) the cues exploited for emotion recognition by LAT and HAT groups are not always the same. These findings are discussed against the background of emotional processing in typically and atypically developed individuals.

  6. Investigating the potential of a novel low-energy house concept with hybrid adaptable thermal storage

    International Nuclear Information System (INIS)

    Hoes, P.; Trcka, M.; Hensen, J.L.M.; Hoekstra Bonnema, B.

    2011-01-01

    Research highlights: → In conventional buildings thermal mass is a permanent building characteristic. → Permanent thermal mass concepts are not optimal in all operational conditions. → We propose a concept that combines the benefits of low and high thermal mass. → Building simulation shows the concept is able to reduce the energy demand with 35%. → Furthermore, the concept increases the performance robustness of the building. -- Abstract: In conventional buildings thermal mass is a permanent building characteristic depending on the building design. However, none of the permanent thermal mass concepts are optimal in all operational conditions. We propose a concept that combines the benefits of buildings with low and high thermal mass by applying hybrid adaptable thermal storage (HATS) systems and materials to a lightweight building. The HATS concept increases building performance and the robustness to changing user behavior, seasonal variations and future climate changes. Building performance simulation is used to investigate the potential of the novel concept for reducing heating energy demand and increasing thermal comfort. Simulation results of a case study in the Netherlands show that the optimal quantity of the thermal mass is sensitive to the change of seasons. This implies that the building performance will benefit from implementing HATS. Furthermore, the potential of HATS is quantified using a simplified HATS model. Calculations show heating energy demand reductions of up to 35% and increased thermal comfort compared to conventional thermal mass concepts.

  7. Design and Parametric Sizing of Deep Space Habitats Supporting NASA'S Human Space Flight Architecture Team

    Science.gov (United States)

    Toups, Larry; Simon, Matthew; Smitherman, David; Spexarth, Gary

    2012-01-01

    NASA's Human Space Flight Architecture Team (HAT) is a multi-disciplinary, cross-agency study team that conducts strategic analysis of integrated development approaches for human and robotic space exploration architectures. During each analysis cycle, HAT iterates and refines the definition of design reference missions (DRMs), which inform the definition of a set of integrated capabilities required to explore multiple destinations. An important capability identified in this capability-driven approach is habitation, which is necessary for crewmembers to live and work effectively during long duration transits to and operations at exploration destinations beyond Low Earth Orbit (LEO). This capability is captured by an element referred to as the Deep Space Habitat (DSH), which provides all equipment and resources for the functions required to support crew safety, health, and work including: life support, food preparation, waste management, sleep quarters, and housekeeping.The purpose of this paper is to describe the design of the DSH capable of supporting crew during exploration missions. First, the paper describes the functionality required in a DSH to support the HAT defined exploration missions, the parameters affecting its design, and the assumptions used in the sizing of the habitat. Then, the process used for arriving at parametric sizing estimates to support additional HAT analyses is detailed. Finally, results from the HAT Cycle C DSH sizing are presented followed by a brief description of the remaining design trades and technological advancements necessary to enable the exploration habitation capability.

  8. IL-6 is Upregulated in Late-Stage Disease in Monkeys Experimentally Infected with Trypanosoma brucei rhodesiense

    Directory of Open Access Journals (Sweden)

    Dawn Nyawira Maranga

    2013-01-01

    Full Text Available The management of human African trypanosomiasis (HAT is constrained by lack of simple-to-use diagnostic, staging, and treatment tools. The search for novel biomarkers is, therefore, essential in the fight against HAT. The current study aimed at investigating the potential of IL-6 as an adjunct parameter for HAT stage determination in vervet monkey model. Four adult vervet monkeys (Chlorocebus aethiops were experimentally infected with Trypanosoma brucei rhodesiense and treated subcuratively at 28 days after infection (dpi to induce late stage disease. Three noninfected monkeys formed the control group. Cerebrospinal fluid (CSF and blood samples were obtained at weekly intervals and assessed for various biological parameters. A typical HAT-like infection was observed. The late stage was characterized by significant (P<0.05 elevation of CSF IL-6, white blood cell count, and total protein starting 35 dpi with peak levels of these parameters coinciding with relapse parasitaemia. Brain immunohistochemical staining revealed an increase in brain glial fibrillary acidic protein expression indicative of reactive astrogliosis in infected animals which were euthanized in late-stage disease. The elevation of IL-6 in CSF which accompanied other HAT biomarkers indicates onset of parasite neuroinvasion and show potential for use as an adjunct late-stage disease biomarker in the Rhodesian sleeping sickness.

  9. Emotion recognition through static faces and moving bodies: a comparison between typically-developed adults and individuals with high level of autistic traits

    Directory of Open Access Journals (Sweden)

    Rossana eActis-Grosso

    2015-10-01

    Full Text Available We investigated whether the type of stimulus (pictures of static faces vs. body motion contributes differently to the recognition of emotions. The performance (accuracy and response times of 25 Low Autistic Traits (LAT group young adults (21 males and 20 young adults (16 males with either High Autistic Traits (HAT group or with High Functioning Autism Spectrum Disorder was compared in the recognition of four emotions (Happiness, Anger, Fear and Sadness either shown in static faces or conveyed by moving bodies (patch-light displays, PLDs. Overall, HAT individuals were as accurate as LAT ones in perceiving emotions both with faces and with PLDs. Moreover, they correctly described non-emotional actions depicted by PLDs, indicating that they perceived the motion conveyed by the PLDs per se. For LAT participants, happiness proved to be the easiest emotion to be recognized: in line with previous studies we found a happy face advantage for faces, which for the first time was also found for bodies (happy body advantage. Furthermore, LAT participants recognized sadness better by static faces and fear by PLDs. This advantage for motion kinematics in the recognition of fear was not present in HAT participants, suggesting that i emotion recognition is not generally impaired in HAT individuals, ii the cues exploited for emotion recognition by LAT and HAT groups are not always the same. These findings are discussed against the background of emotional processing in typically and atypically developed individuals.

  10. Acetylation of Mammalian ADA3 Is Required for Its Functional Roles in Histone Acetylation and Cell Proliferation.

    Science.gov (United States)

    Mohibi, Shakur; Srivastava, Shashank; Bele, Aditya; Mirza, Sameer; Band, Hamid; Band, Vimla

    2016-10-01

    Alteration/deficiency in activation 3 (ADA3) is an essential component of specific histone acetyltransferase (HAT) complexes. We have previously shown that ADA3 is required for establishing global histone acetylation patterns and for normal cell cycle progression (S. Mohibi et al., J Biol Chem 287:29442-29456, 2012, http://dx.doi.org/10.1074/jbc.M112.378901). Here, we report that these functional roles of ADA3 require its acetylation. We show that ADA3 acetylation, which is dynamically regulated in a cell cycle-dependent manner, reflects a balance of coordinated actions of its associated HATs, GCN5, PCAF, and p300, and a new partner that we define, the deacetylase SIRT1. We use mass spectrometry and site-directed mutagenesis to identify major sites of ADA3 acetylated by GCN5 and p300. Acetylation-defective mutants are capable of interacting with HATs and other components of HAT complexes but are deficient in their ability to restore ADA3-dependent global or locus-specific histone acetylation marks and cell proliferation in Ada3-deleted murine embryonic fibroblasts (MEFs). Given the key importance of ADA3-containing HAT complexes in the regulation of various biological processes, including the cell cycle, our study presents a novel mechanism to regulate the function of these complexes through dynamic ADA3 acetylation. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  11. Influence of different seasons during late gestation on Holstein cows' colostrum and postnatal adaptive capability of their calves

    Science.gov (United States)

    Trifković, Julijana; Jovanović, Ljubomir; Đurić, Miloje; Stevanović-Đorđević, Snežana; Milanović, Svetlana; Lazarević, Miodrag; Sladojević, Željko; Kirovski, Danijela

    2018-02-01

    Season may affect calves' thermal comfort and behavior, but the data related to the overall influence of seasonal variations on dams' colostrum and postnatal adaptive capability of calves are limited. The aim of this study was to measure the effects of a 49-day-long low air temperature (LAT) season (5.20 ± 0.46 °C mean air temperature) and a 53-day-long high air temperature (HAT) season (27.40 ± 0.39 °C mean air temperature) on dams' colostrum quality and physiological, biochemical, hormonal, and oxidative stress parameters of their calves during the first 7 days of life. The dams' colostrum was sampled at 2, 14, and 26 h after calving, before feeding of their calves. Calves' blood samples were taken before the first colostrum intake and on days 1, 2, 3, and 7 of life. Calves' physiological parameters were measured on days 0 and 7. HAT season significantly reduced the quality of dams' colostrum. The ingestion of the low-quality colostrum, combined with the thermal discomfort during HAT season, probably provoked impaired physiological, biochemical, hormonal, and oxidative stress parameters in samples taken from the post-colostral calves. Additionally, intravenous glucose tolerance test was performed on day 7, which suggested an enhanced insulin response in HAT season calves. This study highlights the importance of adequate supporting strategies for the care of the late gestation cows and postnatal calves during the HAT season.

  12. Potential of Rhodococcus strains for biotechnological vanillin production from ferulic acid and eugenol.

    Science.gov (United States)

    Plaggenborg, Rainer; Overhage, Jörg; Loos, Andrea; Archer, John A C; Lessard, Philip; Sinskey, Anthony J; Steinbüchel, Alexander; Priefert, Horst

    2006-10-01

    The potential of two Rhodococcus strains for biotechnological vanillin production from ferulic acid and eugenol was investigated. Genome sequence data of Rhodococcus sp. I24 suggested a coenzyme A-dependent, non-beta-oxidative pathway for ferulic acid bioconversion, which involves feruloyl-CoA synthetase (Fcs), enoyl-CoA hydratase/aldolase (Ech), and vanillin dehydrogenase (Vdh). This pathway was proven for Rhodococcus opacus PD630 by physiological characterization of knockout mutants. However, expression and functional characterization of corresponding structural genes from I24 suggested that degradation of ferulic acid in this strain proceeds via a beta-oxidative pathway. The vanillin precursor eugenol facilitated growth of I24 but not of PD630. Coniferyl aldehyde was an intermediate of eugenol degradation by I24. Since the genome sequence of I24 is devoid of eugenol hydroxylase homologous genes (ehyAB), eugenol bioconversion is most probably initiated by a new step in this bacterium. To establish eugenol bioconversion in PD630, the vanillyl alcohol oxidase gene (vaoA) from Penicillium simplicissimum CBS 170.90 was expressed in PD630 together with coniferyl alcohol dehydrogenase (calA) and coniferyl aldehyde dehydrogenase (calB) genes from Pseudomonas sp. HR199. The recombinant strain converted eugenol to ferulic acid. The obtained data suggest that genetically engineered strains of I24 and PD630 are suitable candidates for vanillin production from eugenol.

  13. Microfossil and Fourier transform infrared analyses of Lapita and post-Lapita human dental calculus from Vanuatu, southwest Pacific

    International Nuclear Information System (INIS)

    Horrocks, M.; Nieuwoudt, M.K.; Kinaston, R.; Buckley, H.; Bedford, S.

    2014-01-01

    Here we report on microfossil analysis of human dental calculus from Lapita (3000-2600 yr BP) and post-Lapita (2300-2000 yr BP) burials from Vao and Uripiv, Vanuatu. Phytoliths of introduced Musa and indigenous Heliconia in the calculus suggest the use of these taxa as food wrappings. Phytoliths and most other material in the calculus, namely sponge spicules, calcium oxalate crystals, xylem and charcoal, are unequivocal identifications. Another type of material, comprising degraded objects with a general morphology suggesting starch grains, is uncertain, however, as the unequivocal starch indicator, the Maltese cross, was not observed. We used a new method for calculus analysis, Fourier Transform InfraRed spectroscopy (FTIR), comparing the suspected starch with modern reference starch of prehistoric Pacific crops. Although the ancient FTIR analysis was limited to a small number of suspected starch grains, the results provide another line of evidence for starch. The calculus data are consistent with previous microfossil studies of Lapita deposits at the sites, and demonstrate the efficacy of this technique in contributing to the definition of the history of plant use and diet of early Pacific Island populations. (author)

  14. Limit order book and its modeling in terms of Gibbs Grand-Canonical Ensemble

    Science.gov (United States)

    Bicci, Alberto

    2016-12-01

    In the domain of so called Econophysics some attempts have been already made for applying the theory of thermodynamics and statistical mechanics to economics and financial markets. In this paper a similar approach is made from a different perspective, trying to model the limit order book and price formation process of a given stock by the Grand-Canonical Gibbs Ensemble for the bid and ask orders. The application of the Bose-Einstein statistics to this ensemble allows then to derive the distribution of the sell and buy orders as a function of price. As a consequence we can define in a meaningful way expressions for the temperatures of the ensembles of bid orders and of ask orders, which are a function of minimum bid, maximum ask and closure prices of the stock as well as of the exchanged volume of shares. It is demonstrated that the difference between the ask and bid orders temperatures can be related to the VAO (Volume Accumulation Oscillator), an indicator empirically defined in Technical Analysis of stock markets. Furthermore the derived distributions for aggregate bid and ask orders can be subject to well defined validations against real data, giving a falsifiable character to the model.

  15. Zero-Adjective Contrast in Much-less Ellipsis: The Advantage for Parallel Syntax.

    Science.gov (United States)

    Carlson, Katy; Harris, Jesse A

    2018-01-01

    This paper explores the processing of sentences with a much less coordinator ( I don't own a pink hat, much less a red one ). This understudied ellipsis sentence, one of several focus-sensitive coordination structures, imposes syntactic and semantic conditions on the relationship between the correlate ( a pink hat ) and remnant ( a red one ). We present the case of zero-adjective contrast, in which an NP remnant introduces an adjective without an overt counterpart in the correlate ( I don't own a hat, much less a red one ). Although zero-adjective contrast could in principle ease comprehension by limiting the possible relationships between the remnant and correlate to entailment, we find that zero-adjective contrast is avoided in production and taxing in online processing. Results from several studies support a processing model in which syntactic parallelism is the primary guide for determining contrast in ellipsis structures, even when violating parallelism would assist in computing semantic relationships.

  16. A novel system for continuous protein refolding and on-line capture by expanded bed adsorption

    DEFF Research Database (Denmark)

    Ferré, Henrik; Ruffet, E; Nielsen, L.L.B

    2005-01-01

    A novel two-step protein refolding strategy has been developed, where continuous renaturation-by-dilution is followed by direct capture on an expanded bed adsorption (EBA) column. The performance of the overall process was tested on a N-terminally tagged version of human beta(2)-microglobulin (HAT......-h beta(2)m) both at analytical, small, and preparative scale. In a single scalable operation, extracted and denatured inclusion body proteins from Escherichia coli were continuously diluted into refolding buffer, using a short pipe reactor, allowing for a defined retention and refolding time...... of the overall process was 45%, and the product loss was primarily a consequence of the refolding reaction rather than the EBA step. Full biological activity of HAT-h beta(2)m was demonstrated after removal of the HAT-tag. In contrast to batch refolding, a continuous refolding strategy allows the conditions...

  17. Web security a whitehat perspective

    CERN Document Server

    Wu, Hanqing

    2015-01-01

    MY VIEW OF THE SECURITY WORLDView of the IT Security WorldBrief History of Web SecurityBrief History of Chinese HackersDevelopment Process of Hacking TechniquesRise of Web SecurityBlack Hat, White HatBack to Nature: The Essence of Secret SecuritySuperstition: There Is No Silver BulletSecurity Is an Ongoing ProcessSecurity ElementsHow to Implement Safety AssessmentAsset ClassificationThreat AnalysisRisk AnalysisDesign of Security ProgramsArt of War of White HatPrinciples of Secure by DefaultBlacklist, WhitelistPrinciple of Least PrivilegePrinciple of Defense in DepthPrinciples of Data and Code

  18. Otázka slobodnej vôle v helenistickej filozofii (na pozadí Ciceronovho spisu De fato (Die Frage des freien Willens in der hellenistischen Philosophie (In Anbetracht der Ciceros Schrift De fato

    Directory of Open Access Journals (Sweden)

    Peter Fraňo

    2010-06-01

    Full Text Available In diesem Beitrag ich beschäftige mich mit der Frage: Ist das menschliche handeln vorbestimmt, oder kann der Einzelne frei entscheiden? Diese problematik wurde in der hellenistischen Philosophie sehr verbreitet. Das erste mal hat diese Frage Aristoteles in seinen Werken: Die Nikomachische Etik und vor allem De Interpretatione erforscht, wo hat sich die logische Problematik des sogenannten περὶ δυνατῶν berührt. Die megarischen Philosophen Diodoros Kronos und Philon von Megara hat auf die Lösung des Aristoteles reagiert. Außer der Logik ist die Problematik des freien Willes der Bestandteil der stoischen Physik (Astrologie, Sympathie uns stoische Ursachen gewesen. In meinem Beitrag ich habe auf diese Gesichtspunkte in Anbetracht der Ciceros Schrift De fato hingewiesen.

  19. Key indicators for the monitoring and evaluation of control programmes of human African trypanosomiasis due to Trypanosoma brucei gambiense.

    Science.gov (United States)

    Bouchet, B; Legros, D; Lee, E

    1998-06-01

    Very little research has been devoted to the design of epidemiological tools for the monitoring and evaluation of National Human African Trypanosomiasis (HAT) Control Programmes and daily management decisions are made in the absence of accurate knowledge of the situation. This paper identifies key indicators necessary to make decisions in the field and constantly adjust control activities to changing situations. Examples are derived from the Médecins Sans Frontières (MSF) HAT Control Programme in Adjumani, Uganda. Based on the principles of quality assurance, the focus is placed on process indicators. A conceptual framework derived from a system view/planning cycle perspective is also described for the construction of indicators. Finally, some specific challenging aspects of the epidemiology of HAT are presented and the limitations of the interpretation of the indicators discussed.

  20. The Substitution Effect on Reaction Enthalpies of Antioxidant Mechanisms of Juglone and Its Derivatives in Gas and Solution Phase: DFT Study

    Directory of Open Access Journals (Sweden)

    Aymard Didier Tamafo Fouegue

    2018-01-01

    Full Text Available We examined the structure-reaction enthalpies-antioxidant activity relationship of the molecule library built around juglone and its derivatives at B3LYP/6-31+G(d,p level. Three major antioxidant mechanisms (hydrogen atom transfer (HAT, single electron transfer-proton transfer (SET-PT, and sequential proton loss electron transfer (SPLET have been investigated in five solvents and in the gas phase. The delocalization of the unpaired electrons in the radicals or cation radicals has been explored by the natural bond orbital analysis and the interpretation of spin density maps. The results obtained have proven that the HAT mechanism is the thermodynamically preferred mechanism in the gas phase. But, in the solution phase, the SPLET mechanism has been shown to be more predominant than HAT. The reactivity order of compounds towards selected reactive oxygen species has also been studied.

  1. Trends in tans and skin protection in Australian fashion magazines, 1982 through 1991.

    Science.gov (United States)

    Chapman, S; Marks, R; King, M

    1992-01-01

    We rated 3971 photographs of models from midsummer editions of six Australian fashion magazines from 1982-1983 to 1990-1991 for tan on a 9-point scale, for the presence of hats, for sun-protective clothing, and for shade setting. With the exception of the 1990-1991 sample, there was an increasing proportion of light tans over the years. Men were more likely to be deeply tanned than were women. The proportion of models wearing hats followed an increasing linear trend across the five periods. Three quarters of the outdoor photographs were taken in unshaded settings. In unshaded settings, 17% of the women and 5% of the men wore hats. PMID:1456348

  2. Determination of Spin Inversion Probability, H-Tunneling Correction, and Regioselectivity in the Two-State Reactivity of Nonheme Iron(IV)-Oxo Complexes.

    Science.gov (United States)

    Kwon, Yoon Hye; Mai, Binh Khanh; Lee, Yong-Min; Dhuri, Sunder N; Mandal, Debasish; Cho, Kyung-Bin; Kim, Yongho; Shaik, Sason; Nam, Wonwoo

    2015-04-16

    We show by experiments that nonheme Fe(IV)O species react with cyclohexene to yield selective hydrogen atom transfer (HAT) reactions with virtually no C═C epoxidation. Straightforward DFT calculations reveal, however, that C═C epoxidation on the S = 2 state possesses a low-energy barrier and should contribute substantially to the oxidation of cyclohexene by the nonheme Fe(IV)O species. By modeling the selectivity of this two-site reactivity, we show that an interplay of tunneling and spin inversion probability (SIP) reverses the apparent barriers and prefers exclusive S = 1 HAT over mixed HAT and C═C epoxidation on S = 2. The model enables us to derive a SIP value by combining experimental and theoretical results.

  3. Frequency-domain terahertz transmission spectra of Mn3 and Mn12 single-molecule magnets

    Science.gov (United States)

    Liu, RuiYuan; Zuo, JunWei; Li, YanRong; Zhou, YuRong; Wang, YunPing

    2012-07-01

    Frequency-domain terahertz transmission spectra of Mn3 and Mn12 single molecule magnets (SMMs) have been measured at different temperatures, and hence the anisotropic parameters D 2 and D 4 of the spin Hamiltonian hat H = D_2 hat S_z^2 + D_4 hat S_z^4 have been calculated. For Mn12 SMM, D 2=-10.9 GHz and D 4=-2.59×10-2 GHz, while for Mn3 SMM, D 2=-22.0 GHz and D 4 can be considered negligible. This suggests Mn3 SMM can be considered as a simpler and more suitable candidate for magnetic quantum tunneling research.

  4. An Advanced Microturbine System with Water-Lubricated Bearings

    Directory of Open Access Journals (Sweden)

    Susumu Nakano

    2009-01-01

    Full Text Available A prototype of the next-generation, high-performance microturbine system was developed for laboratory evaluation. Its unique feature is its utilization of water. Water is the lubricant for the bearings in this first reported application of water-lubricated bearings in gas turbines. Bearing losses and limitations under usage conditions were found from component tests done on the bearings and load tests done on the prototype microturbine. The rotor system using the water-lubricated bearings achieved stable rotating conditions at a rated rotational speed of 51,000 rpm. An electrical output of 135 kW with an efficiency of more than 33% was obtained. Water was also utilized to improve electrical output and efficiency through water atomizing inlet air cooling (WAC and a humid air turbine (HAT. The operation test results for the WAC and HAT revealed the WAC and HAT operations had significant effects on both electrical output and electrical efficiency.

  5. Detergent-induced stabilization and improved 3D map of the human heteromeric amino acid transporter 4F2hc-LAT2.

    Science.gov (United States)

    Meury, Marcel; Costa, Meritxell; Harder, Daniel; Stauffer, Mirko; Jeckelmann, Jean-Marc; Brühlmann, Béla; Rosell, Albert; Ilgü, Hüseyin; Kovar, Karin; Palacín, Manuel; Fotiadis, Dimitrios

    2014-01-01

    Human heteromeric amino acid transporters (HATs) are membrane protein complexes that facilitate the transport of specific amino acids across cell membranes. Loss of function or overexpression of these transporters is implicated in several human diseases such as renal aminoacidurias and cancer. HATs are composed of two subunits, a heavy and a light subunit, that are covalently connected by a disulphide bridge. Light subunits catalyse amino acid transport and consist of twelve transmembrane α-helix domains. Heavy subunits are type II membrane N-glycoproteins with a large extracellular domain and are involved in the trafficking of the complex to the plasma membrane. Structural information on HATs is scarce because of the difficulty in heterologous overexpression. Recently, we had a major breakthrough with the overexpression of a recombinant HAT, 4F2hc-LAT2, in the methylotrophic yeast Pichia pastoris. Microgram amounts of purified protein made possible the reconstruction of the first 3D map of a human HAT by negative-stain transmission electron microscopy. Here we report the important stabilization of purified human 4F2hc-LAT2 using a combination of two detergents, i.e., n-dodecyl-β-D-maltopyranoside and lauryl maltose neopentyl glycol, and cholesteryl hemisuccinate. The superior quality and stability of purified 4F2hc-LAT2 allowed the measurement of substrate binding by scintillation proximity assay. In addition, an improved 3D map of this HAT could be obtained. The detergent-induced stabilization of the purified human 4F2hc-LAT2 complex presented here paves the way towards its crystallization and structure determination at high-resolution, and thus the elucidation of the working mechanism of this important protein complex at the molecular level.

  6. Detergent-induced stabilization and improved 3D map of the human heteromeric amino acid transporter 4F2hc-LAT2.

    Directory of Open Access Journals (Sweden)

    Marcel Meury

    Full Text Available Human heteromeric amino acid transporters (HATs are membrane protein complexes that facilitate the transport of specific amino acids across cell membranes. Loss of function or overexpression of these transporters is implicated in several human diseases such as renal aminoacidurias and cancer. HATs are composed of two subunits, a heavy and a light subunit, that are covalently connected by a disulphide bridge. Light subunits catalyse amino acid transport and consist of twelve transmembrane α-helix domains. Heavy subunits are type II membrane N-glycoproteins with a large extracellular domain and are involved in the trafficking of the complex to the plasma membrane. Structural information on HATs is scarce because of the difficulty in heterologous overexpression. Recently, we had a major breakthrough with the overexpression of a recombinant HAT, 4F2hc-LAT2, in the methylotrophic yeast Pichia pastoris. Microgram amounts of purified protein made possible the reconstruction of the first 3D map of a human HAT by negative-stain transmission electron microscopy. Here we report the important stabilization of purified human 4F2hc-LAT2 using a combination of two detergents, i.e., n-dodecyl-β-D-maltopyranoside and lauryl maltose neopentyl glycol, and cholesteryl hemisuccinate. The superior quality and stability of purified 4F2hc-LAT2 allowed the measurement of substrate binding by scintillation proximity assay. In addition, an improved 3D map of this HAT could be obtained. The detergent-induced stabilization of the purified human 4F2hc-LAT2 complex presented here paves the way towards its crystallization and structure determination at high-resolution, and thus the elucidation of the working mechanism of this important protein complex at the molecular level.

  7. Electronic Effects on Room-Temperature, Gas-Phase C-H Bond Activations by Cluster Oxides and Metal Carbides: The Methane Challenge.

    Science.gov (United States)

    Schwarz, Helmut; Shaik, Sason; Li, Jilai

    2017-12-06

    This Perspective discusses a story of one molecule (methane), a few metal-oxide cationic clusters (MOCCs), dopants, metal-carbide cations, oriented-electric fields (OEFs), and a dizzying mechanistic landscape of methane activation! One mechanism is hydrogen atom transfer (HAT), which occurs whenever the MOCC possesses a localized oxyl radical (M-O • ). Whenever the radical is delocalized, e.g., in [MgO] n •+ the HAT barrier increases due to the penalty of radical localization. Adding a dopant (Ga 2 O 3 ) to [MgO] 2 •+ localizes the radical and HAT transpires. Whenever the radical is located on the metal centers as in [Al 2 O 2 ] •+ the mechanism crosses over to proton-coupled electron transfer (PCET), wherein the positive Al center acts as a Lewis acid that coordinates the methane molecule, while one of the bridging oxygen atoms abstracts a proton, and the negatively charged CH 3 moiety relocates to the metal fragment. We provide a diagnostic plot of barriers vs reactants' distortion energies, which allows the chemist to distinguish HAT from PCET. Thus, doping of [MgO] 2 •+ by Al 2 O 3 enables HAT and PCET to compete. Similarly, [ZnO] •+ activates methane by PCET generating many products. Adding a CH 3 CN ligand to form [(CH 3 CN)ZnO] •+ leads to a single HAT product. The CH 3 CN dipole acts as an OEF that switches off PCET. [MC] + cations (M = Au, Cu) act by different mechanisms, dictated by the M + -C bond covalence. For example, Cu + , which bonds the carbon atom mostly electrostatically, performs coupling of C to methane to yield ethylene, in a single almost barrier-free step, with an unprecedented atomic choreography catalyzed by the OEF of Cu + .

  8. Predicting the Impact of Intervention Strategies for Sleeping Sickness in Two High-Endemicity Health Zones of the Democratic Republic of Congo.

    Directory of Open Access Journals (Sweden)

    Kat S Rock

    2017-01-01

    Full Text Available Two goals have been set for Gambian human African trypanosomiasis (HAT, the first is to achieve elimination as a public health problem in 90% of foci by 2020, and the second is to achieve zero transmission globally by 2030. It remains unclear if certain HAT hotspots could achieve elimination as a public health problem by 2020 and, of greater concern, it appears that current interventions to control HAT in these areas may not be sufficient to achieve zero transmission by 2030. A mathematical model of disease dynamics was used to assess the potential impact of changing the intervention strategy in two high-endemicity health zones of Kwilu province, Democratic Republic of Congo. Six key strategies and twelve variations were considered which covered a range of recruitment strategies for screening and vector control. It was found that effectiveness of HAT screening could be improved by increasing effort to recruit high-risk groups for screening. Furthermore, seven proposed strategies which included vector control were predicted to be sufficient to achieve an incidence of less than 1 reported case per 10,000 people by 2020 in the study region. All vector control strategies simulated reduced transmission enough to meet the 2030 goal, even if vector control was only moderately effective (60% tsetse population reduction. At this level of control the full elimination threshold was expected to be met within six years following the start of the change in strategy and over 6000 additional cases would be averted between 2017 and 2030 compared to current screening alone. It is recommended that a two-pronged strategy including both enhanced active screening and tsetse control is implemented in this region and in other persistent HAT foci to ensure the success of the control programme and meet the 2030 elimination goal for HAT.

  9. Performance analysis of humid air turbine cycle with solar energy for methanol decomposition

    International Nuclear Information System (INIS)

    Zhao, Hongbin; Yue, Pengxiu

    2011-01-01

    According to the physical and chemical energy cascade utilization and concept of synthesis integration of variety cycle systems, a new humid air turbine (HAT) cycle with solar energy for methanol decomposition has been proposed in this paper. The solar energy is utilized for methanol decomposing as a heat source in the HAT cycle. The low energy level of solar energy is supposed to convert the high energy level of chemical energy through methanol absorption, realizing the combination of clean energy and normal chemical fuels as compared to the normal chemical recuperative cycle. As a result, the performance of normal chemical fuel thermal cycle can be improved to some extent. Though the energy level of decomposed syngas from methanol is decreased, the cascade utilization of methanol is upgraded. The energy level and exergy losses in the system are graphically displayed with the energy utilization diagrams (EUD). The results show that the cycle's exergy efficiency is higher than that of the conventional HAT cycle by at least 5 percentage points under the same operating conditions. In addition, the cycle's thermal efficiency, exergy efficiency and solar thermal efficiency respond to an optimal methanol conversion. -- Highlights: → This paper proposed and studied the humid air turbine (HAT) cycle with methanol through decomposition with solar energy. → The cycle's exergy efficiency is higher than that of the conventional HAT cycle by at least 5 percentage points. → It is estimated that the solar heat-work conversion efficiency is about 39%, higher than usual. → There is an optimal methanol conversation for the cycle's thermal efficiency and exergy efficiency at given π and TIT. → Using EUD, the exergy loss is decreased by 8 percentage points compared with the conventional HAT cycle.

  10. Simultaneous use of mark-recapture and radiotelemetry to estimate survival, movement, and capture rates

    Science.gov (United States)

    Powell, L.A.; Conroy, M.J.; Hines, J.E.; Nichols, J.D.; Krementz, D.G.

    2000-01-01

    Biologists often estimate separate survival and movement rates from radio-telemetry and mark-recapture data from the same study population. We describe a method for combining these data types in a single model to obtain joint, potentially less biased estimates of survival and movement that use all available data. We furnish an example using wood thrushes (Hylocichla mustelina) captured at the Piedmont National Wildlife Refuge in central Georgia in 1996. The model structure allows estimation of survival and capture probabilities, as well as estimation of movements away from and into the study area. In addition, the model structure provides many possibilities for hypothesis testing. Using the combined model structure, we estimated that wood thrush weekly survival was 0.989 ? 0.007 ( ?SE). Survival rates of banded and radio-marked individuals were not different (alpha hat [S_radioed, ~ S_banded]=log [S hat _radioed/ S hat _banded]=0.0239 ? 0.0435). Fidelity rates (weekly probability of remaining in a stratum) did not differ between geographic strata (psi hat=0.911 ? 0.020; alpha hat [psi11, psi22]=0.0161 ? 0.047), and recapture rates ( = 0.097 ? 0.016) banded and radio-marked individuals were not different (alpha hat [p_radioed, p_banded]=0.145 ? 0.655). Combining these data types in a common model resulted in more precise estimates of movement and recapture rates than separate estimation, but ability to detect stratum or mark-specific differences in parameters was week. We conducted simulation trials to investigate the effects of varying study designs on parameter accuracy and statistical power to detect important differences. Parameter accuracy was high (relative bias [RBIAS] inference from this model, study designs should seek a minimum of 25 animals of each marking type observed (marked or observed via telemetry) in each time period and geographic stratum.

  11. Determinants of Human African Trypanosomiasis Elimination via Paratransgenesis.

    Directory of Open Access Journals (Sweden)

    Jennifer A Gilbert

    2016-03-01

    Full Text Available Human African trypanosomiasis (HAT, transmitted by tsetse flies, has historically infected hundreds of thousands of individuals annually in sub-Saharan Africa. Over the last decade, concerted control efforts have reduced reported cases to below 10,000 annually, bringing complete elimination within reach. A potential technology to eliminate HAT involves rendering the flies resistant to trypanosome infection. This approach can be achieved through the introduction of transgenic Sodalis symbiotic bacteria that have been modified to produce a trypanocide, and propagated via Wolbachia symbionts, which confer a reproductive advantage to the paratransgenic tsetse. However, the population dynamics of these symbionts within tsetse flies have not yet been evaluated. Specifically, the key factors that determine the effectiveness of paratransgenesis have yet to be quantified. To identify the impact of these determinants on T.b. gambiense and T.b. rhodesiense transmission, we developed a mathematical model of trypanosome transmission that incorporates tsetse and symbiont population dynamics. We found that fecundity and mortality penalties associated with Wolbachia or recombinant Sodalis colonization, probabilities of vertical transmission, and tsetse migration rates are fundamental to the feasibility of HAT elimination. For example, we determined that HAT elimination could be sustained over 25 years when Wolbachia colonization minimally impacted fecundity or mortality, and when the probability of recombinant Sodalis vertical transmission exceeded 99.9%. We also found that for a narrow range of recombinant Sodalis vertical transmission probability (99.9-90.6% for T.b. gambiense and 99.9-85.8% for T.b. rhodesiense, cumulative HAT incidence was reduced between 30% and 1% for T.b. gambiense and between 21% and 3% for T.b. rhodesiense, although elimination was not predicted. Our findings indicate that fitness and mortality penalties associated with paratransgenic

  12. Influence of an azolla layer on growth, production and efficiency and use of 15N Labelled urea fertilizer of lowland rice

    International Nuclear Information System (INIS)

    Hendrarti, Etty; Sopandie, Didy; Komarudin Idris; Sisworo, Elsje L

    1998-01-01

    The purpose of this experiment was to study the effect of an Azolla mat on rice growth, percentage of N-total, N derived from fertilizer and urea efficiency. The experiment used a factorial design which consists of 2 factors : the using of an Azolla mat and the doses of N fertilizer. The first factor comprised 2 levels, with (A1) and without an azolla mat (A0). The second factor comprised 4 levels, 0(N0), 30 (N1), 60(N2) and 90 kg N/ha(N3).Application of 15 N labeled Urea done to determine percentage N-derived from Urea efficiency , which was divided in 2 experiment series as follows : application Urea at planting (experiment I) and one month after planting (experiment II). The experiments were carried out in the green house of Agricultural Faculty of IPB and continued in the laboratory of BATAN. Parameters observed were plant height, number of tillers, number of panicles, number of grains/panicle, dry weight of grain, straw and percentage of empty grain. Result of the experiment showed that an Azolla mat, the doses of N fertilizer and interaction of both increased all the parameters observed yield, except for percentage of empathy grain, up to the dose of N fertilizer at 60 kg N/ha and decreased at the dose of N fertilizer at 90 kg N/ha. The treatment of Urea fertilizer doses resulted in a significant difference on the percentage of N- derived from Urea for both experiment, but not for the treatment of an Azolla mat and the interaction of both treatment. An azolla mat, N fertilizer and interaction of both did not result in a significantly difference on the percentage of total-N and Urea efficiency. The best treatment combination was treatment of an azolla mat and dose of Urea fertilizer of 60 kg N/ha. (author)

  13. Cellular Analysis of Boltzmann Most Probable Ideal Gas Statistics

    Science.gov (United States)

    Cahill, Michael E.

    2018-04-01

    Exact treatment of Boltzmann's Most Probable Statistics for an Ideal Gas of Identical Mass Particles having Translational Kinetic Energy gives a Distribution Law for Velocity Phase Space Cell j which relates the Particle Energy and the Particle Population according toB e(j) = A - Ψ(n(j) + 1)where A & B are the Lagrange Multipliers and Ψ is the Digamma Function defined byΨ(x + 1) = d/dx ln(x!)A useful sufficiently accurate approximation for Ψ is given byΨ(x +1) ≈ ln(e-γ + x)where γ is the Euler constant (≈.5772156649) & so the above distribution equation is approximatelyB e(j) = A - ln(e-γ + n(j))which can be inverted to solve for n(j) givingn(j) = (eB (eH - e(j)) - 1) e-γwhere B eH = A + γ& where B eH is a unitless particle energy which replaces the parameter A. The 2 approximate distribution equations imply that eH is the highest particle energy and the highest particle population isnH = (eB eH - 1) e-γwhich is due to the facts that population becomes negative if e(j) > eH and kinetic energy becomes negative if n(j) > nH.An explicit construction of Cells in Velocity Space which are equal in volume and homogeneous for almost all cells is shown to be useful in the analysis.Plots for sample distribution properties using e(j) as the independent variable are presented.

  14. Downregulation of CD44 reduces doxorubicin resistance of CD44+CD24- breast cancer cells

    Directory of Open Access Journals (Sweden)

    Phuc PV

    2011-06-01

    Full Text Available Pham Van Phuc, Phan Lu Chinh Nhan, Truong Hai Nhung, Nguyen Thanh Tam, Nguyen Minh Hoang, Vuong Gia Tue, Duong Thanh Thuy, Phan Kim NgocLaboratory of Stem Cell Research and Application, University of Science, Vietnam National University, Ho Chi Minh, VietnamBackground: Cells within breast cancer stem cell populations have been confirmed to have a CD44+CD24- phenotype. Strong expression of CD44 plays a critical role in numerous types of human cancers. CD44 is involved in cell differentiation, adhesion, and metastasis of cancer cells.Methods: In this study, we reduced CD44 expression in CD44+CD24- breast cancer stem cells and investigated their sensitivity to an antitumor drug. The CD44+CD24- breast cancer stem cells were isolated from breast tumors; CD44 expression was downregulated with siRNAs followed by treatment with different concentrations of the antitumor drug.Results: The proliferation of CD44 downregulated CD44+CD24- breast cancer stem cells was decreased after drug treatment. We noticed treated cells were more sensitive to doxorubicin, even at low doses, compared with the control groups.Conclusions: It would appear that expression of CD44 is integral among the CD44+CD24- cell population. Reducing the expression level of CD44, combined with doxorubicin treatment, yields promising results for eradicating breast cancer stem cells in vitro. This study opens a new direction in treating breast cancer through gene therapy in conjunction with chemotherapy.Keywords: antitumor drugs, breast cancer stem cells, CD44, CD44+CD24- cells, doxorubicin

  15. Sleeping sickness in travelers - do they really sleep?

    Directory of Open Access Journals (Sweden)

    Karin Urech

    2011-11-01

    Full Text Available The number of imported Human African Trypanosomiasis (HAT cases in non-endemic countries has increased over the last years. The objective of this analysis is to describe the clinical presentation of HAT in Caucasian travelers. Literature was screened (MEDLINE, Pubmed using the terms "Human African Trypanosomiasis", "travelers" and "expatriates"; all European languages except Slavic ones were included. Publications without clinical description of patients were only included in the epidemiological analysis. Forty-five reports on Caucasians with T.b. rhodesiense and 15 with T.b. gambiense infections were included in the analysis of the clinical parameters. Both species have presented with fever (T.b. rhodesiense 97.8% and T.b. gambiense 93.3%, headache (50% each and a trypanosomal chancre (T.b. rhodesiense 84.4%, T.b. gambiense 46.7%. While sleeping disorders dominate the clinical presentation of HAT in endemic regions, there have been only rare reports in travelers: insomnia (T.b. rhodesiense 7.1%, T.b. gambiense 21.4%, diurnal somnolence (T.b. rhodesiense 4.8%, T.b. gambiense none. Surprisingly, jaundice has been seen in 24.2% of the Caucasian T.b. rhodesiense patients, but has never been described in HAT patients in endemic regions. These results contrast to the clinical presentation of T.b. gambiense and T.b. rhodesiense HAT in Africans in endemic regions, where the presentation of chronic T.b. gambiense and acute T.b. rhodesiense HAT is different. The analysis of 14 reports on T.b. gambiense HAT in Africans living in a non-endemic country shows that neurological symptoms such as somnolence (46.2%, motor deficit (64.3% and reflex anomalies (14.3% as well as psychiatric symptoms such as hallucinations (21.4% or depression (21.4% may dominate the clinical picture. Often, the diagnosis has been missed initially: some patients have even been hospitalized in psychiatric clinics. In travelers T.b. rhodesiense and gambiense present as acute illnesses

  16. Gauge invariant definition of the jet quenching parameter

    International Nuclear Information System (INIS)

    Benzke, Michael

    2013-01-01

    We use the framework of Glauber extended Soft-Collinear Effective Theory to explicitly derive a gauge invariant expression of the jet quenching parameter q -hat . The effective theory approach offers a systematic power counting scheme at the Lagrangian level and allows for a consistent treatment of the relevant scales in the problem. Employing this approach in a covariant gauge scenario lead to an expression for q -hat containing the expectation value of two light-cone Wilson lines. We find that in a general gauge, additional interaction terms in the Lagrangian have to be considered, leading to the introduction of transverse gauge links

  17. The Scientific Method, Diagnostic Bayes, and How to Detect Epistemic Errors

    Science.gov (United States)

    Vrugt, J. A.

    2015-12-01

    In the past decades, Bayesian methods have found widespread application and use in environmental systems modeling. Bayes theorem states that the posterior probability, P(H|D) of a hypothesis, H is proportional to the product of the prior probability, P(H) of this hypothesis and the likelihood, L(H|hat{D}) of the same hypothesis given the new/incoming observations, \\hat {D}. In science and engineering, H often constitutes some numerical simulation model, D = F(x,.) which summarizes using algebraic, empirical, and differential equations, state variables and fluxes, all our theoretical and/or practical knowledge of the system of interest, and x are the d unknown parameters which are subject to inference using some data, \\hat {D} of the observed system response. The Bayesian approach is intimately related to the scientific method and uses an iterative cycle of hypothesis formulation (model), experimentation and data collection, and theory/hypothesis refinement to elucidate the rules that govern the natural world. Unfortunately, model refinement has proven to be very difficult in large part because of the poor diagnostic power of residual based likelihood functions tep{gupta2008}. This has inspired te{vrugt2013} to advocate the use of 'likelihood-free' inference using approximate Bayesian computation (ABC). This approach uses one or more summary statistics, S(\\hat {D}) of the original data, \\hat {D} designed ideally to be sensitive only to one particular process in the model. Any mismatch between the observed and simulated summary metrics is then easily linked to a specific model component. A recurrent issue with the application of ABC is self-sufficiency of the summary statistics. In theory, S(.) should contain as much information as the original data itself, yet complex systems rarely admit sufficient statistics. In this article, we propose to combine the ideas of ABC and regular Bayesian inference to guarantee that no information is lost in diagnostic model

  18. Information geometry of density matrices and state estimation

    International Nuclear Information System (INIS)

    Brody, Dorje C

    2011-01-01

    Given a pure state vector |x) and a density matrix ρ-hat, the function p(x|ρ-hat)= defines a probability density on the space of pure states parameterised by density matrices. The associated Fisher-Rao information measure is used to define a unitary invariant Riemannian metric on the space of density matrices. An alternative derivation of the metric, based on square-root density matrices and trace norms, is provided. This is applied to the problem of quantum-state estimation. In the simplest case of unitary parameter estimation, new higher-order corrections to the uncertainty relations, applicable to general mixed states, are derived. (fast track communication)

  19. Silizium-Kohlenstoff-Hohlraumstrukturen als Anodenmaterial in Lithium-Ionen- und Lithium-Schwefel-Batterien: Paper präsentiert beim 15. Mitteldeutschen Anorganiker-Nachwuchssymposium, Leipzig, 31.8.2017

    OpenAIRE

    Baasner, Anne; Dörfler, Susanne; Althues, Holger; Kaskel, Stefan

    2017-01-01

    Die Nachfrage nach günstigen Batterien mit hohen Energiedichten hat in den letzten Jahren stark zugenommen. Silizium wird für die nächste Generation von Anodenmaterialien für Lithium-Ionen-Batterien hoch gehandelt. So hat es eine fast zehnmal höhere gravimetrische Kapazität (3590 Ah kg-1 Li15Si4) als die bisher eingesetzten Graphitanoden (370 Ah kg-1) [1]. Mit Lithium-Schwefel-Batterien ist theoretisch eine weitaus höhere Steigerung der Energiedichten möglich. Allerdings haben gegenwärtige Li...

  20. Richard H. Thaler: Wirtschaftsnobelpreisträger 2017

    OpenAIRE

    Bruttel, Lisa Verena; Stolley, Florian

    2017-01-01

    Der diesjährige Nobelpreisträger Richard H. Thaler ist einer breiteren Öffentlichkeit vor allem durch sein mit Cass R. Sunstein gemeinsam verfasstes Buch zum Nudging bekannt geworden. Tatsächlich hat er in den vergangenen 40 Jahren die Entwicklung der Verhaltensökonomie entscheidend mitgeprägt und vorangebracht. Thaler hat die Annahmen hinter dem Modell des Homo oeconomicus untersucht und die Abweichungen menschlichen Verhaltens von den Rationalitätsannahmen auf zwei wesentliche Ursachen zurü...