The High Citadel: The Influence of Harvard Law School.

Science.gov (United States)

Seligman, Joel

The history of Harvard Law School, a modern critique, and a proposed new model for American legal education are covered in this book by a Harvard Law graduate. Harvard Law School is called the "high citadel" of American legal education. Its admissions procedures, faculty selection, curriculum, teaching methods, and placement practices…

Referencing handbook: Harvard

OpenAIRE

Elkin, Judith; Ortega, Marishona; Williams, Helen

2016-01-01

University of Lincoln approved guide to Harvard referencing. Providing guidelines on how to reference 75 sources of information. The second edition includes extended guidance on how to reference, all new examples, additional annotated diagrams and an index to help you locate sources.

Imagining Harvard: Changing Visions of Harvard in Fiction, 1890-1940

Science.gov (United States)

Anderson, Christian K.; Clark, Daniel A.

2012-01-01

Harvard is easily the most recognizable American institution of higher education, freighted with rich associations to the nation's leaders. This article provides an opportunity to examine the history of higher education through a lens often overlooked--fiction. By doing so, the authors provide a richer understanding of a particular institution and…

Harvard Education Letter. Volume 26, Number 4, July-August 2010

Science.gov (United States)

Chauncey, Caroline T., Ed.

2010-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Learning Progressions in Science: A New Approach Emphasizes Sustained Instruction in Big Ideas (Patti Hartigan); (2) Putting the "Boy Crisis" in…

Harvard Education Letter. Volume 23, Number 1, January-February 2007

Science.gov (United States)

Chauncey, Caroline, Ed.

2007-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Response to Intervention: A New Approach to Reading Instruction Aims to Catch Struggling Readers Early (Nancy Walser); (2) Getting Advisory Right: Focus and…

Harvard Education Letter. Volume 26, Number 2, March-April 2010

Science.gov (United States)

Chauncey, Caroline T., Ed.

2010-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Online Testing, Version 1.0: Oregon's Adaptive Computer-Based Accountability Test Offers a Peek at a Brave New Future (Robert Rothman); (2) Beyond…

Harvard Education Letter. Volume 26, Number 5, September-October 2010

Science.gov (United States)

Walser, Nancy, Ed.

2010-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Scenes from the School Turnaround Movement: Passion, Frustration, Mid-Course Corrections Mark Rapid Reforms (Laura Pappano); (2) The Media Savvy Educator:…

Harvard Education Letter. Volume 28, Number 2, March-April 2012

Science.gov (United States)

Chauncey, Caroline T., Ed.

2012-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Course Credits on the Quick: Controversial Online Recovery Programs Speed the Path to Graduation (Andrew Brownstein); (2) Collaborating to Make Schools More Inclusive…

Harvard Education Letter. Volume 27, Number 4, July-August 2011

Science.gov (United States)

Chauncey, Caroline T., Ed.

2011-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Integrated Data Systems Link Schools and Communities: Researchers Combine School and Non-School Data to Inform Interventions and Policy (Patti Hartigan);…

Harvard Education Letter. Volume 25, Number 3, May-June 2009

Science.gov (United States)

Chauncey, Caroline T., Ed.

2009-01-01

"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Improving Teaching and Learning through Instructional Rounds (Lee Teitel); (2) Developmentally Appropriate Practice in the Age of Testing: New Reports Outline Key Principles…

Harvard Education Letter. Volume 25, Number 6, November-December 2009

Science.gov (United States)

Chauncey, Caroline T., Ed.

2009-01-01

"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) "Platooning" Instruction: Districts Weigh Pros and Cons of Departmentalizing Elementary Schools (Lucy Hood); (2) Behind the Classroom Door: A Rare Glimpse Indicates the…

Harvard Education Letter. Volume 24, Number 4, July-August 2008

Science.gov (United States)

Chauncey, Caroline, Ed.

2008-01-01

"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Taking the Measure of New Teachers: California Shifts from Standardized Tests to Performance-Based Assessment as a Condition of Licensure (Robert Rothman);…

Harvard Education Letter. Volume 27, Number 1, January-February 2011

Science.gov (United States)

Walser, Caroline T., Ed.

2011-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) The Greening of Environmental Ed: Teachers Focus on Complexity, Evidence, and Letting Students Draw Their Own Conclusions (Lucy Hood); (2) Like Teacher,…

Harvard Education Letter. Volume 27, Number 3, May-June 2011

Science.gov (United States)

Chauncey, Caroline T., Ed.

2011-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Bringing Art into School, Byte by Byte: Innovative Programs Use Technology to Expand Access to the Arts (Patti Hartigan); (2) Differentiated Instruction…

Harvard Education Letter. Volume 25, Number 4, July-August 2009

Science.gov (United States)

Chauncey, Caroline T., Ed.

2009-01-01

"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Putting the Brakes on "Summer Slide": Modified School Calendars Build in Time to Enrich Learning and Sustain Gains (Brigid Schulte); (2) Closing…

Harvard Education Letter. Volume 25, Number 1, January-February 2009

Science.gov (United States)

Chauncey, Caroline, Ed.

2009-01-01

"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Learning Across Distance: Virtual-Instruction Programs Are Growing Rapidly, but the Impact on "Brick-and-Mortar" Classrooms Is Still up in the Air…

Harvard Education Letter. Volume 22, Number 6, November-December 2006

Science.gov (United States)

Chauncey, Caroline, Ed.

2006-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) (In)formative Assessments: New Tests and Activities Can Help Teachers Guide Student Learning (Robert Rothman); (2) Recent Research on the Achievement Gap: How Lifestyle…

Harvard Education Letter. Volume 25, Number 5, September-October 2009

Science.gov (United States)

Chauncey, Caroline T., Ed.

2009-01-01

"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) The Invisible Hand in Education Policy: Behind the Scenes, Economists Wield Unprecedented Influence (David McKay Wilson); (2) Bonding and Bridging: Schools Open Doors for…

Harvard Education Letter. Volume 26, Number 1, January-February 2010

Science.gov (United States)

Chauncey, Caroline T., Ed.

2010-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Charters and Unions: What's the Future for This Unorthodox Relationship? (Alexander Russo); (2) From Special Ed to Higher Ed: Transition Planning for Disabled Students Focuses…

Harvard Education Letter. Volume 24, Number 3, May-June 2008

Science.gov (United States)

Chauncey, Caroline, Ed.

2008-01-01

"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) "Equity, Access, and Opportunity": Despite Challenges, More Districts Adopt One-to-One Laptop Programs (Colleen Gillard); (2) Small Kids, Big Words: Research-Based Strategies…

Harvard Education Letter. Volume 26, Number 6, November-December 2010

Science.gov (United States)

Walser, Nancy, Ed.

2010-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Video Games Take Testing to the Next Level: Researchers See Promise in Game-Like Assessments That Measure Complex Skills (Robert Rothman); (2) An Academic…

Harvard Education Letter. Volume 28, Number 1, January-February 2012

Science.gov (United States)

Walser, Nancy, Ed.

2012-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Using Theater to Teach Social Skills: Researchers Document Improvements for Children with Autism (Patti Hartigan); (2) The Family Model of Schooling Revisited: Few Teachers,…

Harvard Education Letter. Volume 23, Number 5, September-October 2007

Science.gov (United States)

Chauncey, Caroline, Ed.

2007-01-01

"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Confronting the Autism Epidemic: New Expectations for Children with Autism Means a New Role for Public Schools (Kate McKenna); (2) Internet Research 101:…

Derek Bok after 20 Years at Harvard's Helm: An Interview.

Science.gov (United States)

Chronicle of Higher Education, 1990

1990-01-01

The interview with Derek Bok addresses his reasons for stepping down from the Harvard presidency; cost-cutting efforts at Harvard; "selective excellence" as a planning principle; current needs of Harvard; corruption of higher education by corporate ties; the changing college presidency; and the role of ethical considerations in decision…

Harvard Education Letter. Volume 21, Number 6, November-December 2005

Science.gov (United States)

Chauncey, Caroline, Ed.

2005-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Is History... History?: Standards, Accountability, and the Future of Our Nation's Past (Robert Rothman); (2) Curriculum Access for All: How Teachers Can Use Universal Design…

Harvard Education Letter. Volume 27, Number 2, March-April 2011

Science.gov (United States)

Walser, Nancy, Ed.

2011-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Hybrid Schools for the iGeneration: New Schools Combine "Bricks" and "Clicks" (Brigid Schulte); (2) Dual Language Programs on the Rise: "Enrichment" Model Puts Content Learning…

Harvard Education Letter. Volume 26, Number 3, May-June 2010

Science.gov (United States)

Chauncey, Caroline T., Ed.

2010-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Unleashing the "Brain Power" of Groups in the Classroom: The Neuroscience behind Collaborative Work (Nancy Walser); (2) Putting AP to the Test: New Research Assesses the…

Harvard Education Letter. Volume 25, Number 2, March-April 2009

Science.gov (United States)

Chauncey, Caroline, Ed.

2009-01-01

"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Money and Motivation: New Initiatives Rekindle Debate over the Link between Rewards and Student Achievement (David McKay Wilson); (2) An Inexact Science: What Are the Technical…

Harvard Education Letter. Volume 24, Number 6, November-December 2008

Science.gov (United States)

Chauncey, Caroline, Ed.

2008-01-01

"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) When Worlds Collide: Universal PreK Brings New Challenges for Public Elementary Schools (David McKay Wilson); (2) Answers and Questions: Schools Survey Their Students--and…

Harvard Education Letter. Volume 23, Number 6, November-December 2007

Science.gov (United States)

Chauncey, Caroline, Ed.

2007-01-01

"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Charting a New Course toward Racial Integration: Districts Seek Legal Routes to Capture the Benefits of Diversity (Brigid Schulte); (2) Voluntary Integration: Two Views--(a)…

Harvard Education Letter. Volume 27, Number 6, November-December 2011

Science.gov (United States)

Walser, Nancy, Ed.

2011-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) With Cheating on the Rise, Schools Respond (David McKay Wilson); (2) Waldorf Education in Public Schools: Educators Adopt--and Adapt--This Developmental, Arts-Rich Approach…

Harvard Education Letter. Volume 24, Number 2, March-April 2008

Science.gov (United States)

Chauncey, Caroline, Ed.

2008-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Educating Teenage Immigrants: High Schools Experiment with Ways to Group New English-Language Learners (Lucy Hood); (2) Hot Topics and Key Words: Pilot Project Brings Teachers…

Historical contributions from the Harvard system to adult spine surgery.

Science.gov (United States)

Schoenfeld, Andrew J

2011-10-15

Literature review. To document the historical contributions from the Harvard Medical School system to the field of adult spine surgery. Despite the fact that significant contributions to the discipline of spinal surgery have derived from the Harvard system, no prior study documents the history of the Harvard spine services in a cohesive narrative. This historical perspective reviews the history of adult spine surgery within the Harvard system and outlines the significant contributions made by orthopedic and neurosurgical practitioners to the field. Literature reviews were performed from historical works, as well as scientific publications to fashion a cohesive review covering the history of spine surgery at Harvard from the early 19th century to the present. The development of the spine surgical services at the three main Harvard hospitals, and significant spine surgical personalities within the system, are discussed, including W. Jason Mixter, MD, Joseph S. Barr Sr., MD, and Marius N. Smith-Petersen, MD. Substantial developments that have arisen from the Harvard teaching hospitals include the recognition of disc herniation as the cause of radicular symptoms in the lower extremities, the description of lumbar discectomy as a surgical treatment for radicular pain, osteotomy for the correction of spinal deformity, and the first attempt to create a systematic algorithm capable of informing treatment for cervical spine trauma. Despite humble beginnings, the surgeons and scientists at Harvard have influenced nearly every facet of spine surgery over the course of the last two centuries.

Harvard Education Letter. Volume 24, Number 1, January-February 2008

Science.gov (United States)

Chauncey, Caroline, Ed.

2008-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Leadership Lessons From Schools Becoming "Data Wise" (Jennifer L. Steele and Kathryn Parker Boudett); (2) A Guide on the Side: Mentors Help New Leaders Prepare for Life in the…

Harvard Education Letter. Volume 27, Number 5, September-October 2011

Science.gov (United States)

Chauncey, Caroline T., Ed.

2011-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Teaching Students to Ask Their Own Questions: One Small Change Can Yield Big Results (Dan Rothstein and Luz Santana); (2) Voice of Experience: Jerry Weast--Leading a System…

Harvard Education Letter. Volume 23, Number 2, March-April 2007

Science.gov (United States)

Chauncey, Caroline, Ed.

2007-01-01

"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) More Than "Making Nice": Getting Teachers to (Truly) Collaborate (Laura Pappano); (2) "Doing the Critical Things First": An Aligned Approach to PreK and Early Elementary Math;…

Harvard Education Letter. Volume 24, Number 5, September-October 2008

Science.gov (United States)

Chauncey, Caroline, Ed.

2008-01-01

"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Teaching 21st Century Skills: What Does It Look Like in Practice? (Nancy Walser); (2) Getting and Spending: Schools and Districts Share Lessons on the Effective Uses of…

Harvard Education Letter. Volume 23, Number 3, May-June 2007

Science.gov (United States)

Chauncey, Caroline, Ed.

2007-01-01

"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) The Road to School Improvement: It's Hard, It's Bumpy, and It Takes as Long as It Takes (Richard F. Elmore and Elizabeth A. City); (2) Better Teaching with Web Tools: How…

Harvard Education Letter. Volume 23, Number 4, July-August 2007

Science.gov (United States)

Chauncey, Caroline, Ed.

2007-01-01

"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) Meeting of the Minds: The Parent-Teacher Conference Is the Cornerstone of School-Home Relations. How Can It Work for All Families? (Laura Pappano); (2) In Search of That "Third…

Citing & Referencing Using the Harvard Style: Examples

OpenAIRE

Cullen, John G.

2016-01-01

This teaching resource supplements 2 videos which are available online on YouTube. These videos are titled: • ‘Citing and referencing using the Harvard Style (Part 1)’ - Available at https://www.youtube.com/watch?v=9X1UjtfgTU8 • Citing and referencing using the Harvard Style (Part 2)’ - Available at https://www.youtube.com/watch?v=Hj_EXIFviZA

K-12 Professional Development at the Harvard Forest LTER

Science.gov (United States)

Bennett, K.

2012-12-01

As part of the Long Term Ecological Research (LTER) program, the Harvard Forest in Petersham, Massachusetts seeks to train the next generation of researchers, by involving K-12 grade students and their teachers in hands-on, field-based, ecological research in their own schoolyard and community. Students learn to collect data on important long-term ecological issues and processes. Student data are then shared on the Harvard Forest website. To prepare teachers for project protocols, teachers are given direct access to Harvard ecologists with professional development workshops and on-line resources. With the Harvard Forest Schoolyard LTER program, students can participate in three different research projects focusing on phenology, invasive insects, and vernal pools. Teachers attend the Summer Institute for Teachers to learn project content and methods. They return in fall to participate in one of three levels of data workshops to learn how to input, manage, and analyze project data. In the spring, teachers again meet with the Harvard ecologists about project protocols, and to share, through a series of teacher presentations, the ways these project themes are being integrated into class curricula. These professional development opportunities result in long term collaborative partnerships with local schools and the Harvard Forest LTER. In addition to the LTER Schoolyard Ecology Program, the Harvard Forest has supported a successful Research Experience for Teachers (RET) program for the last six years. Throughout the summer, teachers work on research projects alongside Harvard Forest and affiliated scientists, post-docs, graduate students, and REU's (Research Experience for Undergraduates). The RET program provides teachers with the opportunity to build scientific knowledge, develop an understanding of research methods, and translate their new knowledge and experiences into cutting edge classroom lessons. The past two summers I have worked with Dr. Andrew Richardson

When Harvard said no to eugenics: the J. Ewing Mears Bequest, 1927.

Science.gov (United States)

Lombardo, Paul A

2014-01-01

James Ewing Mears (1838-1919) was a founding member of the Philadelphia Academy of Surgery. His 1910 book, The Problem of Race Betterment, laid the groundwork for later authors to explore the uses of surgical sterilization as a eugenic measure. Mears left $60,000 in his will to Harvard University to support the teaching of eugenics. Although numerous eugenic activists were on the Harvard faculty, and two of its Presidents were also associated with the eugenics movement, Harvard refused the Mears gift. The bequest was eventually awarded to Jefferson Medical College in Philadelphia. This article explains why Harvard turned its back on a donation that would have supported instruction in a popular subject. Harvard's decision illustrates the range of opinion that existed on the efficacy of eugenic sterilization at the time. The Mears case also highlights a powerful irony: the same week Harvard turned down the Mears legacy, the U.S. Supreme Court endorsed eugenic sterilization in the landmark case of Buck v. Bell. Justice Oliver Wendell Holmes, Jr., graduate of Harvard and former member of its law faculty wrote the opinion in that case, including the famous conclusion: "Three generations of imbeciles are enough."

33 CFR 100.101 - Harvard-Yale Regatta, Thames River, New London, CT.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Harvard-Yale Regatta, Thames... OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.101 Harvard... passed their positions. At that time, spectator vessels located south of the Harvard Boathouse may...

Alliances in Human Biology: The Harvard Committee on Industrial Physiology, 1929-1939.

Science.gov (United States)

Oakes, Jason

2015-08-01

In 1929 the newly-reorganized Rockefeller Foundation funded the work of a cross-disciplinary group at Harvard University called the Committee on Industrial Physiology (CIP). The committee's research and pedagogical work was oriented towards different things for different members of the alliance. The CIP program included a research component in the Harvard Fatigue Laboratory and Elton May's interpretation of the Hawthorne Studies; a pedagogical aspect as part of Wallace Donham's curriculum for Harvard Business School; and Lawrence Henderson's work with the Harvard Pareto Circle, his course Sociology 23, and the Harvard Society of Fellows. The key actors within the CIP alliance shared a concern with training men for elite careers in government service, business leadership, and academic prominence. But the first communications between the CIP and the Rockefeller Foundation did not emphasize training in human biology. Instead, the CIP presented itself as a coordinating body that would be able to organize all the varied work going on at Harvard that did not fit easily into one department, and it was on this basis that the CIP became legible to the President of Harvard, A. Lawrence Lowell, and to Rockefeller's Division of Social Sciences. The members of the CIP alliance used the term human biology for this project of research, training and institutional coordination.

Buying Access to Ivy--A Way to Revive Harvard

Science.gov (United States)

Halfond, Jay A.

2010-01-01

Of the many, many articles written on Harvard University's endowment woes, the author has yet to read one actually sympathetic with Harvard. Perhaps this reflects one's gleeful voyeurism when the high-and-mighty fall, or sense of justice that the reckless should pay for their recklessness, or belief that no university truly needs or deserves such…

Harvard Business Schoolis töötav ainus eestlane Toomas Laarits / intervjueerinud Luise Savik

Index Scriptorium Estoniae

Laarits, Toomas

2011-01-01

Intervjuu Harvard College'i bakalaureuseõppe lõpetanud ja Harvard Business Schoolis kahe õppejõu assistendina töötava eestlase Toomas Laaritsaga Harvard Business Schooli magistriõppest ja elust tudengina Harvardis

Conference Scene: Personalized Medicine comes to Harvard.

Science.gov (United States)

Greenberg, Tarryn

2012-01-01

The Seventh Annual Harvard Personalized Medicine Conference was held at The Joseph B Martin Conference Center at the Harvard Medical School in Boston, MA, USA on the 9-10 November 2011. The 2-day conference program was designed to highlight the impact that personalized medicine is currently making clinically as it enters the healthcare delivery system. Going forward, policies, plans and actions of stakeholders including those from government, academia and the private sector need to be informed and guided by recent experience - all of which the conference program set out to explore. The conference attracted over 600 national and international thought leaders all involved in personalized healthcare.

75 FR 33328 - Notice of Inventory Completion: Peabody Museum of Archaeology and Ethnology, Harvard University...

Science.gov (United States)

2010-06-11

... Archaeology and Ethnology, Harvard University, Cambridge, MA; Correction AGENCY: National Park Service..., Harvard University, Cambridge, MA. The human remains and associated funerary objects were removed from... Archaeology and Ethnology, Harvard [[Page 33329

77 FR 46120 - Notice of Inventory Completion: Peabody Museum of Archaeology and Ethnology, Harvard University...

Science.gov (United States)

2012-08-02

... Inventory Completion: Peabody Museum of Archaeology and Ethnology, Harvard University, Cambridge, MA... Museum of Archaeology and Ethnology, Harvard University, Cambridge, MA. The human remains and associated..., Repatriation Coordinator, Peabody Museum of Archaeology and Ethnology, Harvard University, 11 Divinity Avenue...

76 FR 62842 - Notice of Inventory Completion: Peabody Museum of Archaeology and Ethnology, Harvard University...

Science.gov (United States)

2011-10-11

...: Peabody Museum of Archaeology and Ethnology, Harvard University, Cambridge, MA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Peabody Museum of Archaeology and Ethnology, Harvard... the human remains may contact the Peabody Museum of Archaeology and Ethnology, Harvard University...

75 FR 58431 - Notice of Inventory Completion: Peabody Museum of Archaeology and Ethnology, Harvard University...

Science.gov (United States)

2010-09-24

... Archaeology and Ethnology, Harvard University, Cambridge, MA; Correction AGENCY: National Park Service... in the possession of the Peabody Museum of Archaeology and Ethnology, Harvard University, Cambridge... was a project of Harvard University faculty in 1972. No known individuals were identified. No...

Bit by Bit: Innovating at the Periphery to Extend Harvard's Core

Science.gov (United States)

Laserna, Catalina; Leitner, Henry

2008-01-01

Faculty instructional time is a critical resource at all universities, but particularly in a major research institution like Harvard. Operating on the periphery of the Faculty of Arts and Sciences, Harvard's division of Continuing Education is often at a disadvantage when attempting to recruit senior faculty. However, through its distance…

Space Radar Image of Harvard Forest

Science.gov (United States)

1999-01-01

This is a radar image of the area surrounding the Harvard Forest in north-central Massachusetts that has been operated as a ecological research facility by Harvard University since 1907. At the center of the image is the Quabbin Reservoir, and the Connecticut River is at the lower left of the image. The Harvard Forest itself is just above the reservoir. Researchers are comparing the naturally occurring physical disturbances in the forest and the recent and projected chemical disturbances and their effects on the forest ecosystem. Agricultural land appears dark blue/purple, along with low shrub vegetation and some wetlands. Urban development is bright pink; the yellow to green tints are conifer-dominated vegetation with the pitch pine sand plain at the middle left edge of the image appearing very distinctive. The green tint may indicate pure pine plantation stands, and deciduous broadleaf trees appear gray/pink with perhaps wetter sites being pinker. This image was acquired by the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) aboard the space shuttle Endeavour. SIR-C/X-SAR, a joint mission of the German, Italian and the United States space agencies, is part of NASA's Mission to Planet Earth. The image is centered at 42.50 degrees North latitude and 72.33 degrees West longitude and covers an area of 53 kilometers 63 by kilometers (33 miles by 39 miles). The colors in the image are assigned to different frequencies and polarizations of the radar as follows: red is L-band horizontally transmitted and horizontally received; green is L-band horizontally transmitted and vertically received; and blue is C-band horizontally transmitted and horizontally received.

Harvard Aging Brain Study : Dataset and accessibility

NARCIS (Netherlands)

Dagley, Alexander; LaPoint, Molly; Huijbers, Willem; Hedden, Trey; McLaren, Donald G.; Chatwal, Jasmeer P.; Papp, Kathryn V.; Amariglio, Rebecca E.; Blacker, Deborah; Rentz, Dorene M.; Johnson, Keith A.; Sperling, Reisa A.; Schultz, Aaron P.

2017-01-01

The Harvard Aging Brain Study is sharing its data with the global research community. The longitudinal dataset consists of a 284-subject cohort with the following modalities acquired: demographics, clinical assessment, comprehensive neuropsychological testing, clinical biomarkers, and neuroimaging.

The Harvard Project Physics Film Program

Science.gov (United States)

Bork, Alfred M.

1970-01-01

States the philosophy behind the Harvard Project Physics (HPP) film program. Describes the three long HPP films. Lists the 48 color film loops covering six broad topics, primarily motion and energy. The 8-mm silent loops are synchronized with the text materials. Explains some of the pedagogical possibilities of these film loops. (RR)

Cummings/Ju - Harvard; Emory | Division of Cancer Prevention

Science.gov (United States)

Principal Investigator: Richard D Cummings, PhDInstitution: Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA Principal Investigator: Tongzhong Ju, MD, PhDInstitution: Emory University, Atlanta, GA |

The Lowells of Boston and the Founding of University Extension at Harvard

Science.gov (United States)

Shinagel, Michael

2009-01-01

In this article, the author uses the occasion of the centennial of University Extension at Harvard to document how this unique educational institution came into being and why it became associated with Harvard University. He traces the prominent role played by the Lowell family in establishing the Lowell Institute of Boston in the late 1830s and…

Harvard and the Academic Glass Ceiling

Science.gov (United States)

Drago, Robert

2007-01-01

Drew Gilpin Faust was recently appointed president of Harvard University, and is the first female to hold the position. Women now lead half of the eight institutions that make up the Ivy League. But focusing on highly accomplished women such as Faust misses a larger point. Women may be taking faculty positions in record numbers, but most of those…

Study on decay of 118Xe and 119Xe by means of mass-separator on-line with a synchrocyclotron

International Nuclear Information System (INIS)

Berlovich, Eh.E.; Batist, L.Kh.; Blinnikov, Yu.S.

1976-01-01

The decay of sup(118, 119)Xe isotopes has been investigated. An experimental device involving a mass-separator operating in line with a synchrocyclotron is briefly outlined. The elements to be investigated were isolated from a proton-irradiated target by the 'on-beam-chemistry' methods and transferred into the mass-separator ion source. The Xe separated ions are transported to detectors in an experimental ha ll. The energies and relative γ ray intensities of 118 Xe → 118 J and of 119 Xe → 119 J decays ar presented. The error of the γ ray energy determination does not exceed 0.6 keV. Obtained are the periods of half-life: for 118 Xe - (3.8+-0.9) min, for 119 Xe - (5.8+-0.3) min. The decay scheme for 119 Xe is made up. The scheme of 119 Xe levels is well inscribed into the general systematics of the J odd isotope levels. On the basis of obtained and known data the spin values are described to the 119 J levels

The Harvard organic photovoltaic dataset.

Science.gov (United States)

Lopez, Steven A; Pyzer-Knapp, Edward O; Simm, Gregor N; Lutzow, Trevor; Li, Kewei; Seress, Laszlo R; Hachmann, Johannes; Aspuru-Guzik, Alán

2016-09-27

The Harvard Organic Photovoltaic Dataset (HOPV15) presented in this work is a collation of experimental photovoltaic data from the literature, and corresponding quantum-chemical calculations performed over a range of conformers, each with quantum chemical results using a variety of density functionals and basis sets. It is anticipated that this dataset will be of use in both relating electronic structure calculations to experimental observations through the generation of calibration schemes, as well as for the creation of new semi-empirical methods and the benchmarking of current and future model chemistries for organic electronic applications.

Address by William J. Bennett, United States Secretary of Education. (Harvard University, Cambridge, Massachusetts).

Science.gov (United States)

Bennett, William J.

The extent to which U.S. colleges and universities contribute to the fulfillment of students' lives is discussed by Secretary of Education William Bennett in an address to Harvard University. Secretary Bennett's observations are based on his experiences as a law student, freshman proctor, and tutor at Harvard University, as well as his subsequent…

Establishment of the Department of Anaesthesia at Harvard Medical School-1969.

Science.gov (United States)

Mizrahi, Ilan; Desai, Sukumar P

2016-02-01

The first academic departments of anesthesia were established in the United States at the University of Wisconsin-Madison in 1927, with Ralph M. Waters named as chairman, and in the UK at Oxford University in 1937, with Robert Macintosh as chairman. Compared to these early departments, more than 3 decades would pass before Harvard Medical School decided it was time to establish a department of anaesthesia, in 1969. We examine the forces on both sides of the issue, for and against, and how they played out in the late 1960s. Published articles, books, interviews, and biographical and autobiographical notes as well as primary source documents such as reports of department and medical school committee meetings were examined to obtain information relevant to our investigation. The late 1960s were an ideal time for the chiefs of anesthesia at the various Harvard teaching hospitals to make a strong argument in favor of establishment of an independent department of anaesthesia. Although strongly opposed by Francis Daniels Moore, Chief of Surgery at Peter Bent Brigham Hospital, an independent department at Harvard was established in 1969. The recognition of anesthesia as a distinctive specialty at universities across the country as well as the specific concerns over administration, hiring, and the future of the clinical service in the 1960s provided overwhelming support for the establishment of a separate, free-standing department of anaesthesia at one of the most tradition-bound universities in the United States-Harvard. Copyright © 2016 Elsevier Inc. All rights reserved.

Harvard Law School Proxy Access Roundtable

OpenAIRE

Bebchuk, Lucian Arye; Hirst, Scott

2010-01-01

This paper contains the proceedings of the Proxy Access Roundtable that was held by the Harvard Law School Program on Corporate Governance on October 7, 2009. The Roundtable brought together prominent participants in the debate - representing a range of perspectives and experiences - for a day of discussion on the subject. The day’s first two sessions focused on the question of whether the Securities and Exchange Commission should provide an access regime, or whether it should leave the adopt...

The Harvard organic photovoltaic dataset

Science.gov (United States)

Lopez, Steven A.; Pyzer-Knapp, Edward O.; Simm, Gregor N.; Lutzow, Trevor; Li, Kewei; Seress, Laszlo R.; Hachmann, Johannes; Aspuru-Guzik, Alán

2016-01-01

The Harvard Organic Photovoltaic Dataset (HOPV15) presented in this work is a collation of experimental photovoltaic data from the literature, and corresponding quantum-chemical calculations performed over a range of conformers, each with quantum chemical results using a variety of density functionals and basis sets. It is anticipated that this dataset will be of use in both relating electronic structure calculations to experimental observations through the generation of calibration schemes, as well as for the creation of new semi-empirical methods and the benchmarking of current and future model chemistries for organic electronic applications. PMID:27676312

Psychiatry in American Medical Education: The Case of Harvard's Medical School, 1900-1945.

Science.gov (United States)

Abraham, Tara H

2018-01-01

As American psychiatrists moved from the asylum to the private clinic during the early twentieth century, psychiatry acquired a growing presence within medical school curricula. This shift in disciplinary status took place at a time when medical education itself was experiencing a period of reform. By examining medical school registers at Harvard University, records from the Dean's office of Harvard's medical school, and oral histories, this paper examines the rise in prominence of psychiatry in medical education. Three builders of Harvard psychiatry - Elmer E. Southard, C. Macfie Campbell, and Harry C. Solomon - simultaneously sought to mark territory for psychiatry and its relevance. In doing so, they capitalized on three related elements: the fluidity that existed between psychiatry and neurology, the new venues whereby medical students gained training in psychiatry, and the broader role of patrons, professional associations, and certification boards, which sought to expand psychiatry's influence in the social and cultural life of twentieth-century America.

A guide to the Harvard referencing system.

Science.gov (United States)

Dwyer, M

This article explains how to reference an academic work using the Harvard system. Instructions comply with the relevant British standards, i.e. BS 5605:1990, BS 1629:1989 and BS 6371:1983. The importance of referencing in an approved manner is discussed and problem areas such as joint authors, corporate authorship and unpublished works are examined. The issue of second-hand references that are not addressed by the standards is also explained.

Much Ado about Something? James Bryant Conant, Harvard University, and Nazi Germany in the 1930s

Science.gov (United States)

Urban, Wayne J.; Smith, Marybeth

2015-01-01

This paper discusses the actions of noted Harvard University president James Bryant Conant, taken in regard to the Nazi government in Germany, from the time of Conant's becoming president of Harvard University in 1933 to the time of the widespread pogrom in Germany of 9-10 November 1938, known as Kristallnacht. Conant's attitudes and actions…

Harvard University High Energy Physics progress report

International Nuclear Information System (INIS)

1992-01-01

The principal goals of this work are to carry out forefront programs in high energy physics research and to provide first rate educational opportunities for students. The experimental program supported through HEPL is carried out at the major accelerator centers in the world and addresses some of the most important questions in high energy physics. The program is based at Harvard's High Energy Physics Laboratory, which has offices, computing facilities, and engineering support, and both electronics and machine shops

Harvard Boycott Turns out to Be Referendum on Affirmative Action.

Science.gov (United States)

Manners, Bernadette

1982-01-01

Discusses the controversy that arose at Harvard Law School as a proposed course on civil rights and racial discrimination, to be taught by Black and White lawyers, led to a boycott movement by minority students who demanded more Black faculty members at the school.(MJL)

Implementation of the Harvard Case Method through a Plan-Do-Check-Act Framework in a University Course

Science.gov (United States)

Shieh, Ruey S.; Lyu, Jr Jung; Cheng, Yun-Yao

2012-01-01

In 2005, the Harvard Business School began to promote the Harvard case method (HCM) within the Asian region. Because of differences in classroom culture between Asian and Western countries, Asian participants' reaction to the HCM implementation is of interest. This study explores how the western initiated method was implemented in one of the Asian…

Harvard University High Energy Physics

International Nuclear Information System (INIS)

1993-01-01

The mainly experimental research program in high energy physics at Harvard is summarized in a descriptive fashion according to the following outline: Proton endash antiproton colliding beam program at Fermilab -- CDF (forward/backward electromagnetic calorimeters -- FEM, central muon extension -- CMX, gas calorimetry and electronics development, front-end electronics upgrades, software development, physics analysis, timetable), electron -- positron collisions in the upsilon region -- CLEO (the hardware projects including CLEO II barrel TOF system and silicon drift detector R ampersand D, physics analysis), search for ν μ to ν τ oscillations with the NOMAD experiment at CERN, the solenoidal detector collaboration at the SSC, muon scattering at FNAL -- E665, the L3 experiment, and phenomenological analysis of high-energy bar pp cross sections. 149 refs

Crimson Tide: The Harvard Books on Astronomy

Science.gov (United States)

Lindner, R. P.

2001-12-01

The Harvard Books on Astronomy, a series of crimson clad, fully illustrated volumes, cornered, for more than a generation, the market of readers interested in astronomy. A large number of astronomers owe their first serious initiation to the literature of astronomy to these books. Their style, presentation, design, and tone marked a clear departure from the inherited traditions in the field. Each summed up a field, awarded points for merit, and staked out paths for future study. No doubt each of the more mature readers of this abstract has his or her favorite volume, and even his or her own favorite edition of a particular volume. How the volumes evolved and what happened to the series with Harlow Shapley's retirement are not only questions in the history of the book but also form a commentary on the standards of scientific writing for the educated public. For this the major evidence comes from the volumes by Shapley himself, Leo Goldberg and Lawrence Aller, and the Boks. This paper discusses the origins of the series, the purpose of the works, the varying successes of the volumes, and the impact they had on the future astronomical community. In part, this is a contribution to the impact of Harlow Shapley upon the wider field and the role of Harvard in the American astronomical community. It is also a meditation upon the ways of recruitment into the field and forming ways of looking at research problems.

Framework for Sustaining Innovation at Baker Library, Harvard Business School

Science.gov (United States)

Dolan, Meghan; Hemment, Michael; Oliver, Stephanie

2017-01-01

Baker Library at Harvard Business School is increasingly asked by the school's faculty to create custom digital information products to enhance course assignments and to find novel ways of electronically disseminating faculty research. In order to prioritize these requests, as well as facilitate, manage, and track the resulting projects, the…

Exceptional Portable Sundials at Harvard

Science.gov (United States)

Schechner, Sara

2014-06-01

The Collection of Historical Scientific Instruments at Harvard University has the largest assemblage of sundials in North America. The dials date from the 16th to the 19th centuries, and most are designed to be carried in one’s pocket or put on a window sill. They take advantage of the sun’s changing altitude, azimuth, hour angle, or a combination of the foregoing in order to find the time. Many are also usable at a wide range of latitudes, and therefore are suitable tools for travelers. Fashioned of wood, paper, ivory, brass, and silver, the sundials combine mathematical projections of the sun’s apparent motion with artistry, fashion, and exquisite craftsmanship. This paper will explore the wide variety of sundials and what they tell us about the people who made and used them.

Black Faculty at Harvard: Does the Pipeline Defense Hold Water?

Science.gov (United States)

Cross, Theodore

1994-01-01

The hiring practices of Harvard University are examined as they relate to the argument that black college faculty members are not available because there are no blacks in the "pipeline" of Ph.D.s. This spurious defense is an anachronism that must be reexamined in considering racial diversity at America's universities. (SLD)

The Harvard Automated Phone Task: new performance-based activities of daily living tests for early Alzheimer's disease.

Science.gov (United States)

Marshall, Gad A; Dekhtyar, Maria; Bruno, Jonathan M; Jethwani, Kamal; Amariglio, Rebecca E; Johnson, Keith A; Sperling, Reisa A; Rentz, Dorene M

2015-12-01

Impairment in activities of daily living is a major burden for Alzheimer's disease dementia patients and caregivers. Multiple subjective scales and a few performance-based instruments have been validated and proven to be reliable in measuring instrumental activities of daily living in Alzheimer's disease dementia but less so in amnestic mild cognitive impairment and preclinical Alzheimer's disease. To validate the Harvard Automated Phone Task, a new performance-based activities of daily living test for early Alzheimer's disease, which assesses high level tasks that challenge seniors in daily life. In a cross-sectional study, the Harvard Automated Phone Task was associated with demographics and cognitive measures through univariate and multivariate analyses; ability to discriminate across diagnostic groups was assessed; test-retest reliability with the same and alternate versions was assessed in a subset of participants; and the relationship with regional cortical thickness was assessed in a subset of participants. Academic clinical research center. One hundred and eighty two participants were recruited from the community (127 clinically normal elderly and 45 young normal participants) and memory disorders clinics at Brigham and Women's Hospital and Massachusetts General Hospital (10 participants with mild cognitive impairment). As part of the Harvard Automated Phone Task, participants navigated an interactive voice response system to refill a prescription (APT-Script), select a new primary care physician (APT-PCP), and make a bank account transfer and payment (APT-Bank). The 3 tasks were scored based on time, errors, and repetitions from which composite z-scores were derived, as well as a separate report of correct completion of the task. We found that the Harvard Automated Phone Task discriminated well between diagnostic groups (APT-Script: p=0.002; APT-PCP: pHarvard Automated Phone Task and executive function (APT-PCP: pHarvard Automated Phone Task, which

Harvard Air Pollution Health Study in six cites in the USA

Energy Technology Data Exchange (ETDEWEB)

Spengler, J D; Ferris, Jr, B G

1985-08-01

The Harvard Air Pollution Health Study has been a ten year prospective study of respiratory symptoms and pulmonary function of children and adults living in six US communities. Indices of acute and chronic effects of air pollution exposures have been studied. Evidence is presented for adverse effects of ambient and indoor air pollution on children. Relationships between ambient TSP concentrations and hospital emergency room admissions, temporary decreases in pulmonary functions and prevalence of community bronchitis all indicate a slight adverse effect. Refinements of these relationships will occur when fine fraction and acid sulfate aerosol concentrations are incorporated into the health analysis. Exposures to cigarette smoke at home are associated with increased reported respiratory symptoms in children. There is a negative relationship between maternal smoking and age and sex adjusted height for children. Results from indoor and personal exposure studies have lead to the design of an acute symptoms and indoor air pollution study. Between 1985 and 1988 1800 children will be tracked for a year while respirable particles, nitrogen dioxide, water vapor and air exchange will be measured in their homes. Using continuous sulfate/sulfuric acid monitors built at Harvard, we are characterizing the magnitude, duration and frequency of acid aerosol events in each of our study cities. This information will be utilized in the analysis of the respiratory symptom data. The Harvard Air Pollution Health Study is providing information on the relationship among health variables and air pollutant exposures. In addition, this study will add to our understanding of lung growth and aging and the risk factors associated with chronic respiratory disabilities.

"He sees the development of children's concepts upon a background of sociology": Jean Piaget's honorary degree at Harvard University in 1936.

Science.gov (United States)

Hsueh, Yeh

2004-02-01

In the recent memory, Jean Piaget has been known as a cognitive developmental psychologist. But in 1936 when Harvard gave him his first honorary degree, he was recognized mainly as a sociologist. Why did Harvard honor him in 1936? Who knew his work well enough to nominate him? This article will address these questions by exploring archival documents from different sources. Evidence draws our attention to a broad social and intellectual endeavor in philanthropy, other social sciences, and especially industrial research that brought Piaget across the water. This article also attempts to interpret the circumstances of the nomination process inside and outside of Harvard University by using a theory of institutional design. It suggests that embodied in Harvard's honor of Piaget in 1936 was an idealistic act in social designing for a future society.

Harvard Aging Brain Study: Dataset and accessibility.

Science.gov (United States)

Dagley, Alexander; LaPoint, Molly; Huijbers, Willem; Hedden, Trey; McLaren, Donald G; Chatwal, Jasmeer P; Papp, Kathryn V; Amariglio, Rebecca E; Blacker, Deborah; Rentz, Dorene M; Johnson, Keith A; Sperling, Reisa A; Schultz, Aaron P

2017-01-01

The Harvard Aging Brain Study is sharing its data with the global research community. The longitudinal dataset consists of a 284-subject cohort with the following modalities acquired: demographics, clinical assessment, comprehensive neuropsychological testing, clinical biomarkers, and neuroimaging. To promote more extensive analyses, imaging data was designed to be compatible with other publicly available datasets. A cloud-based system enables access to interested researchers with blinded data available contingent upon completion of a data usage agreement and administrative approval. Data collection is ongoing and currently in its fifth year. Copyright © 2015 Elsevier Inc. All rights reserved.

The two (quality) faces of HCHP (Harvard Community Health Plan).

Science.gov (United States)

Burda, D

1991-03-18

When it comes to total quality management, Harvard Community Health Plan has two personalities. It's using the principles espoused by such TQM gurus as Joseph Juran to reduce costs and improve quality in its clinics and offices. But HCHP also is enhancing its image in the healthcare industry by teaching TQM principles to others for big bucks.

Harvard Project Physics Newsletter 10. The Project Physics Course, Text.

Science.gov (United States)

Harvard Univ., Cambridge, MA. Harvard Project Physics.

A short description of the availability of Harvard Project Physics course components is given as is a discussion of the growth of the use of Project Physics in schools, including some enrollment data and survey results. Locations of the 1970 and 1971 Summer Institutes are listed. Adaptations of Project Physics course outside the United States are…

Activities of daily living measured by the Harvard Automated Phone Task track with cognitive decline over time in non-demented elderly

Science.gov (United States)

Marshall, Gad A.; Aghjayan, Sarah L.; Dekhtyar, Maria; Locascio, Joseph J.; Jethwani, Kamal; Amariglio, Rebecca E.; Johnson, Keith A.; Sperling, Reisa A.; Rentz, Dorene M.

2017-01-01

Background Impairment in activities of daily living is a major burden to both patients and caregivers. Mild impairment in instrumental activities of daily living is often seen at the stage of mild cognitive impairment. The field of Alzheimer’s disease is moving toward earlier diagnosis and intervention and more sensitive and ecologically valid assessments of instrumental or complex activities of daily living are needed. The Harvard Automated Phone Task, a novel performance-based activities of daily living instrument, has the potential to fill this gap. Objective To further validate the Harvard Automated Phone Task by assessing its longitudinal relationship to global cognition and specific cognitive domains in clinically normal elderly and individuals with mild cognitive impairment. Design In a longitudinal study, the Harvard Automated Phone Task was associated with cognitive measures using mixed effects models. The Harvard Automated Phone Task’s ability to discriminate across diagnostic groups at baseline was also assessed. Setting Academic clinical research center. Participants Two hundred and seven participants (45 young normal, 141 clinically normal elderly, and 21 mild cognitive impairment) were recruited from the community and the memory disorders clinics at Brigham and Women’s Hospital and Massachusetts General Hospital. Measurements Participants performed the three tasks of the Harvard Automated Phone Task, which consist of navigating an interactive voice response system to refill a prescription (APT-Script), select a new primary care physician (APT-PCP), and make a bank account transfer and payment (APT-Bank). The 3 tasks were scored based on time, errors, repetitions, and correct completion of the task. The primary outcome measure used for each of the tasks was total time adjusted for correct completion. Results The Harvard Automated Phone Task discriminated well between young normal, clinically normal elderly, and mild cognitive impairment

Program Spotlight: Dana Farber/Harvard Cancer Center Partnership Receives $8 Million Grant

Science.gov (United States)

The UMass Boston and Dana Farber/Harvard Cancer Center PACHE Partnership received a grant to start-up a Center for Personalized Cancer Therapy on the UMass Boston campus. The center is deigned to train underrepresented students to work in cancer research.

The "nuts and bolts" of implementing shared medical appointments: the Harvard Vanguard Medical Associates experience.

Science.gov (United States)

Berger-Fiffy, Jill

2012-01-01

Harvard Vanguard Medical Associates (Harvard Vanguard) decided to develop a Shared Medical Appointment (SMA) program in 2007 for a variety of reasons. The program has launched 86 SMAs in 17 specialties at 12 sites and has exceeded 13 000 patient visits. Currently, the practice offers 54 SMAs and is believed to be the largest program in the country. This article provides an overview regarding staffing, space and equipment, project planning, promotional materials, training programs, workflow development, and the use of quality improvement (ie, LEAN) tools used to monitor the work to be completed and the metrics to date.

The Harvard Automated Phone Task: new performance-based activities of daily living tests for early Alzheimer’s disease

Science.gov (United States)

Marshall, Gad A.; Dekhtyar, Maria; Bruno, Jonathan M.; Jethwani, Kamal; Amariglio, Rebecca E.; Johnson, Keith A.; Sperling, Reisa A.; Rentz, Dorene M.

2015-01-01

Background Impairment in activities of daily living is a major burden for Alzheimer’s disease dementia patients and caregivers. Multiple subjective scales and a few performance-based instruments have been validated and proven to be reliable in measuring instrumental activities of daily living in Alzheimer’s disease dementia but less so in amnestic mild cognitive impairment and preclinical Alzheimer’s disease. Objective To validate the Harvard Automated Phone Task, a new performance-based activities of daily living test for early Alzheimer’s disease, which assesses high level tasks that challenge seniors in daily life. Design In a cross-sectional study, the Harvard Automated Phone Task was associated with demographics and cognitive measures through univariate and multivariate analyses; ability to discriminate across diagnostic groups was assessed; test-retest reliability with the same and alternate versions was assessed in a subset of participants; and the relationship with regional cortical thickness was assessed in a subset of participants. Setting Academic clinical research center. Participants One hundred and eighty two participants were recruited from the community (127 clinically normal elderly and 45 young normal participants) and memory disorders clinics at Brigham and Women’s Hospital and Massachusetts General Hospital (10 participants with mild cognitive impairment). Measurements As part of the Harvard Automated Phone Task, participants navigated an interactive voice response system to refill a prescription (APT-Script), select a new primary care physician (APT-PCP), and make a bank account transfer and payment (APT-Bank). The 3 tasks were scored based on time, errors, and repetitions from which composite z-scores were derived, as well as a separate report of correct completion of the task. Results We found that the Harvard Automated Phone Task discriminated well between diagnostic groups (APT-Script: p=0.002; APT-PCP: pHarvard Automated Phone

College Board Response to "Harvard Educational Review" Article by Santelices and Wilson

Science.gov (United States)

College Board, 2010

2010-01-01

This is the College Board's response to a research article by Drs. Maria Veronica Santelices and Mark Wilson in the Harvard Educational Review, entitled "Unfair Treatment? The Case of Freedle, the SAT, and the Standardization Approach to Differential Item Functioning" (see EJ930622).

Harvard-MIT research program in short-lived radiopharmaceuticals. Progress report, March 1, 1985-February 28, 1986

International Nuclear Information System (INIS)

1986-03-01

The Harvard-MIT Research Program in Short-Lived Radiopharmaceuticals was established in 1977 to foster interaction among groups working at Harvard Medical School, the Massachusetts Institute of Technology and the Massachusetts General Hospital in fields related to radiopharmaceutical chemistry. From these collaborations and building upon the special, but different, strengths of the participating individuals, laboratories and institutions, it was hoped that original approaches would be found for the design of new, clinically useful, labeled compounds. We believe that examination of the record demonstrates that this has been a fruitful alliance

Newspaper Coverage of the Harvard Medicare Project: Regional Distinctions/Discreet Disregard?

Science.gov (United States)

Payne, J. Gregory

A study examined American newspaper coverage of the Harvard Medicare Project proposal of 1986, a major health policy proposal calling for comprehensive reforms in the national health program. Using Burrelle's news clipping service which includes every daily newspaper (over 1500) in the United States, all 75 newspaper articles on the project from…

Searching Harvard Business Review Online. . . Lessons in Searching a Full Text Database.

Science.gov (United States)

Tenopir, Carol

1985-01-01

This article examines the Harvard Business Review Online (HBRO) database (bibliographic description fields, abstracts, extracted information, full text, subject descriptors) and reports on 31 sample HBRO searches conducted in Bibliographic Retrieval Services to test differences between searching full text and searching bibliographic record. Sample…

A distributed model: redefining a robust research subject advocacy program at the Harvard Clinical and Translational Science Center.

Science.gov (United States)

Winkler, Sabune J; Cagliero, Enrico; Witte, Elizabeth; Bierer, Barbara E

2014-08-01

The Harvard Clinical and Translational Science Center ("Harvard Catalyst") Research Subject Advocacy (RSA) Program has reengineered subject advocacy, distributing the delivery of advocacy functions through a multi-institutional, central platform rather than vesting these roles and responsibilities in a single individual functioning as a subject advocate. The program is process-oriented and output-driven, drawing on the strengths of participating institutions to engage local stakeholders both in the protection of research subjects and in advocacy for subjects' rights. The program engages stakeholder communities in the collaborative development and distributed delivery of accessible and applicable educational programming and resources. The Harvard Catalyst RSA Program identifies, develops, and supports the sharing and distribution of expertise, education, and resources for the benefit of all institutions, with a particular focus on the frontline: research subjects, researchers, research coordinators, and research nurses. © 2014 Wiley Periodicals, Inc.

Neutron flux density and secondary-particle energy spectra at the 184-inch synchrocyclotron medical facility

International Nuclear Information System (INIS)

Smith, A.R.; Schimmerling, W.; Henson, A.M.; Kanstein, L.L.; McCaslin, J.B.; Stephens, L.D.; Thomas, R.H.; Ozawa, J.; Yeater, F.W.

1978-07-01

Helium ions, with an energy of 920 MeV, produced by the 184-inch synchrocyclotron of the Lawrence Berkeley Laboratory are now being used in a pilot series to determine their efficacy in the treatment of tumors of large volume. The techniques for production of the large uniform radiation fields required for these treatments involve the use of beam-limiting collimators and energy degraders. Interaction of the primary beam with these beam components produces secondary charged particles and neutrons. The sources of neutron production in the beam transport system of the alpha-particle beam have been identified and their magnitudes have been determined. Measurements with activation detectors and pulse counters of differing energy responses have been used to determine secondary particle spectra at various locations on the patient table. These spectra are compared to a calculation of neutron production based on best estimates derived from published cross sections. Agreement between the calculated spectra and those derived from experimental measurements is obtained (at the 10 to 20% level) when the presence of charged particles is taken into account. The adsorbed dose in soft tissue is not very sensitive to the shape of the incident neutron energy spectrum, and the values obtained from unfolding the experimental measurements agree with the values obtained from the calculated spectra within the estimated uncertainty of +-25%. These values are about 3 x 10 -3 rad on the beam axis and about 1 x 10 -3 rad at 20 cm or more from the beam axis, per rad deposited by the incident alpha-particle beam. Estimates of upper limit dose to the lens of the eye and red bone marrow are approximately 10 rad and approximately 1 rad, respectively, for a typical treatment plan. The absorbed dose to the lens of the eye is thus well below the threshold value for cataractogenesis estimated for fission neutrons. An upper limit for the risk of leukemia is estimated to be approximately 0.04%

Can Ethics Be Taught? Perspectives, Challenges, and Approaches at Harvard Business School.

Science.gov (United States)

Piper, Thomas R.; And Others

This book describes in five chapters how the Harvard Business School has redeveloped its curriculum to place leadership, ethics, and corporate responsibility at the center of its mission. Chapter 1, "Rediscovery of Purpose: The Genesis of the Leadership, Ethics, and Corporate Responsibility Initiative," (Thomas R. Piper) describes the…

Political Activity at Harvard College Observatory in the Shapley ERA (1921-1952): Controversy and Consequences.

Science.gov (United States)

Welther, Barbara L.

1993-12-01

Soon after Harlow Shapley became director of HCO in 1921, he established himself as a scientist who would speak out and take action on national and international issues. Recognizing the importance of international cooperation in astronomy, he frequently traveled abroad and in turn invited foreign scientists to visit and work at HCO. By the mid-1930s, Shapley was actively rescuing refugee scientists in war-torn Europe and placing them in American universities. Both Harvard and the FBI took note of his activities. Shapley feared intervention of any kind from either academia or the government. Desperate for funding, however, he finally went to Washington and lobbied Congress to set up the NSF. Through 1945, when Truman succeeded Roosevelt, Shapley pursued his political activities freely. That year he travelled to Moscow to represent Harvard at the 220th anniversary celebration of the Academy of Sciences. In Moscow he advocated international cooperation between Soviet and American scientists. Consequently, Shapley was subpoenaed for interrogation in 1946 by John Rankin, who served during the Truman administration as a one-man committee to investigate un-American activities. The ordeal infuriated Shapley. Headlines about it infuriated some Harvard alumni who urged the university to fire him. Although Shapley was nearing retirement, President Conant stood by his right to keep his job. By 1950, when Senator Joseph McCarthy was compiling a list of Communist sympathizers in the State Department, the FBI had a dossier on Shapley. McCarthy subpoenaed Shapley, but could not intimidate him. The Senator continued the witch hunt with Shapley's associates. First he harassed Martha Betz Shapley, then Donald Menzel. Both cleared themselves. Other associates, such as Bart Bok, were spared. Ultimately, the interrogation worked in Menzel's favor. It disassociated him from Shapley's ideology and political activities. When the Harvard Corporation sought the next director of HCO, Menzel

Science at Harvard University: Historical Perspectives, edited by Clark A. Elliott and Margaret W. Rossiter. Lehigh University Press, Bethlehem, 1992

OpenAIRE

Christenson, Andrew L.

1992-01-01

This volume contains historical studies of several sciences as practiced at Harvard University. Two of these studies have relevance to the history of archaeology. A chapter by Toby Appel focuses upon the scientific career of Jeffries Wyman, first curator of Harvard's Peabody Museum. She contrasts Wyman's unassuming character with the dominating personality of his mentor and contemporary Louis Agassiz. Trained as a medi...

Physiological effects of bioceramic material: harvard step, resting metabolic rate and treadmill running assessments.

Science.gov (United States)

Leung, Ting-Kai; Kuo, Chia-Hua; Lee, Chi-Ming; Kan, Nai-Wen; Hou, Chien-Wen

2013-12-31

Previous biomolecular and animal studies have shown that a room-temperature far-infrared-rayemitting ceramic material (bioceramic) demonstrates physical-biological effects, including the normalization of psychologically induced stress-conditioned elevated heart rate in animals. In this clinical study, the Harvard step test, the resting metabolic rate (RMR) assessment and the treadmill running test were conducted to evaluate possible physiological effects of the bioceramic material in human patients. The analysis of heart rate variability (HRV) during the Harvard step test indicated that the bioceramic material significantly increased the high-frequency (HF) power spectrum. In addition, the results of RMR analysis suggest that the bioceramic material reduced oxygen consumption (VO2). Our results demonstrate that the bioceramic material has the tendency to stimulate parasympathetic responses, which may reduce resting energy expenditure and improve cardiorespiratory recovery following exercise.

Harvard University Program on Technology and Society 1964-1972. A Final Review.

Science.gov (United States)

Harvard Univ., Cambridge, MA. Program on Technology and Society.

Eight years of research by the Harvard University's Program on Technology and Society are summarized. Lengthy abstracts of the 29 books and 164 articles that resulted from the Program, as well as interim accounts of projects not yet completed are presented. The report is divided into four parts; institutions (including business, education, and…

The 1951 Harvard student uprising against the intern match.

Science.gov (United States)

Nakayama, Don K; Hendren, W Hardy

2017-06-01

In the fall of 1951, a group of Harvard medical students led by W. Hardy Hendren, III organized a national movement against the newly instituted match that would assign graduating seniors to hospital internship programs. Before then, hospitals with intern positions to fill rushed to secure commitments from students, who in turn accepted the first decent offer that came their way. Knowing that students could not risk waiting for a better offer, hospitals pushed them into making early commitments. When some students began getting offers in their junior and sophomore years, medical schools, professional groups, and hospitals organized the National Inter-association Committee on Internships to deal with the issue. The intern match was thus organized and scheduled to take place in 1952. When the plan was announced in mid-October 1951, Hendren recognized that the proposed algorithm placed students at a disadvantage if they did not get their first choice of hospitals. Facing resistance at every step from the National Inter-association Committee on Internships and putting his standing at Harvard Medical School at risk, Hendren led a nationwide movement of medical students to change the procedure to one that favored students' choices. Their success <1 month later established in the inaugural match the fundamental ethic of today's National Resident Matching Program to favor students' preferences at every step of the process. Copyright © 2016 Elsevier Inc. All rights reserved.

Overview of Light-Ion Beam Therapy

International Nuclear Information System (INIS)

Chu, William T.

2006-01-01

In 1930, Ernest Orlando Lawrence at the University of California at Berkeley invented the cyclotron. One of his students, M. Stanley Livingston, constructed a 13-cm diameter model that had all the features of early cyclotrons, accelerating protons to 80 keV using less than 1 kV on a semi-circular accelerating electrode, now called the ''dee''. Soon after, Lawrence constructed the first two-dee 27-Inch (69-cm) Cyclotron, which produced protons and deuterons of 4.8 MeV. In 1939, Lawrence constructed the 60-Inch (150-cm) Cyclotron, which accelerated deuterons to 19 MeV. Just before WWII, Lawrence designed a 184-inch cyclotron, but the war prevented the building of this machine. Immediately after the war ended, the Veksler-McMillan principle of phase stability was put forward, which enabled the transformation of conventional cyclotrons to successful synchrocyclotrons. When completed, the 184-Inch Synchrocyclotron produced 340-MeV protons. Following it, more modern synchrocyclotrons were built around the globe, and the synchrocyclotrons in Berkeley and Uppsala, together with the Harvard cyclotron, would perform pioneering work in treatment of human cancer using accelerated hadrons (protons and light ions). When the 184-Inch Synchrocyclotron was built, Lawrence asked Robert Wilson, one of his former graduate students, to look into the shielding requirements for of the new accelerator. Wilson soon realized that the 184-Inch would produce a copious number of protons and other light ions that had enough energy to penetrate human body, and could be used for treatment of deep-seated diseases. Realizing the advantages of delivering a larger dose in the Bragg peak when placed inside deep-seated tumors, he published in a medical journal a seminal paper on the rationale to use accelerated protons and light ions for treatment of human cancer. The precise dose localization provided by protons and light ions means lower doses to normal tissues adjacent to the treatment volume

Overview of Light-Ion Beam Therapy

Energy Technology Data Exchange (ETDEWEB)

Chu, William T.

2006-03-16

In 1930, Ernest Orlando Lawrence at the University of California at Berkeley invented the cyclotron. One of his students, M. Stanley Livingston, constructed a 13-cm diameter model that had all the features of early cyclotrons, accelerating protons to 80 keV using less than 1 kV on a semi-circular accelerating electrode, now called the ''dee''. Soon after, Lawrence constructed the first two-dee 27-Inch (69-cm) Cyclotron, which produced protons and deuterons of 4.8 MeV. In 1939, Lawrence constructed the 60-Inch (150-cm) Cyclotron, which accelerated deuterons to 19 MeV. Just before WWII, Lawrence designed a 184-inch cyclotron, but the war prevented the building of this machine. Immediately after the war ended, the Veksler-McMillan principle of phase stability was put forward, which enabled the transformation of conventional cyclotrons to successful synchrocyclotrons. When completed, the 184-Inch Synchrocyclotron produced 340-MeV protons. Following it, more modern synchrocyclotrons were built around the globe, and the synchrocyclotrons in Berkeley and Uppsala, together with the Harvard cyclotron, would perform pioneering work in treatment of human cancer using accelerated hadrons (protons and light ions). When the 184-Inch Synchrocyclotron was built, Lawrence asked Robert Wilson, one of his former graduate students, to look into the shielding requirements for of the new accelerator. Wilson soon realized that the 184-Inch would produce a copious number of protons and other light ions that had enough energy to penetrate human body, and could be used for treatment of deep-seated diseases. Realizing the advantages of delivering a larger dose in the Bragg peak when placed inside deep-seated tumors, he published in a medical journal a seminal paper on the rationale to use accelerated protons and light ions for treatment of human cancer. The precise dose localization provided by protons and light ions means lower doses to normal tissues adjacent to the

DIGITAL ACCESS TO A SKY CENTURY AT HARVARD: INITIAL PHOTOMETRY AND ASTROMETRY

International Nuclear Information System (INIS)

Laycock, S.; Tang, S.; Grindlay, J.; Los, E.; Simcoe, R.; Mink, D.

2010-01-01

Digital Access to a Sky Century at Harvard (DASCH) is a project to digitize the collection of ∼500,000 glass photographic plates held at Harvard College Observatory. The collection spans the time period from 1880 to 1985, during which time every point on the sky was been observed from 500 to 1000 times. In this paper, we describe the DASCH commissioning run, during which we developed the data-reduction pipeline, characterized the plates and fine-tuned the digitizer's performance and operation. This initial run consisted of 500 plates taken from a variety of different plate series, all containing the open cluster Praeseppe (M44). We report that accurate photometry at the 0.1 mag level is possible on the majority of plates, and demonstrate century-long light curves of various types of variable stars in and around M44. DASCH will generate a public online archive of the entire plate collection, including images, source catalogs, and light curves for nearly all astronomical objects brighter than about 17th magnitude.

Digital Access to a Sky Century at Harvard: Initial Photometry and Astrometry

Science.gov (United States)

Laycock, S.; Tang, S.; Grindlay, J.; Los, E.; Simcoe, R.; Mink, D.

2010-10-01

Digital Access to a Sky Century at Harvard (DASCH) is a project to digitize the collection of ~500,000 glass photographic plates held at Harvard College Observatory. The collection spans the time period from 1880 to 1985, during which time every point on the sky was been observed from 500 to 1000 times. In this paper, we describe the DASCH commissioning run, during which we developed the data-reduction pipeline, characterized the plates and fine-tuned the digitizer's performance and operation. This initial run consisted of 500 plates taken from a variety of different plate series, all containing the open cluster Praeseppe (M44). We report that accurate photometry at the 0.1 mag level is possible on the majority of plates, and demonstrate century-long light curves of various types of variable stars in and around M44. DASCH will generate a public online archive of the entire plate collection, including images, source catalogs, and light curves for nearly all astronomical objects brighter than about 17th magnitude.

Harvard ER-2 OH laser-induced fluorescence instrument

Science.gov (United States)

Wennberg, Paul O.; Anderson, James G.

1994-01-01

The Harvard ER-2 OH instrument is scheduled to be integrated into the NASA ER-2 high altitude aircraft ozone payload in August 1992. Design and fabrication is presently underway. This experiment is a descendant of a balloon borne instrument designed and built in the mid-1980s. The ER-2 instrument is being designed to measure OH and HO2 as part of the NASA ozone payload for the investigation of processes controlling the concentration of stratospheric ozone. Although not specifically designed to do so, it is hoped that valid measurements of OH and HO2 can be made in the remote free troposphere with this instrument.

The Flip Sides of Full-Text: Superindex and the Harvard Business Review/Online.

Science.gov (United States)

Dadlez, Eva M.

1984-01-01

This article illustrates similarities between two different types of full-text databases--Superindex, Harvard Business Review/Online--and uses them as arena to demonstrate search and display applications of full-text. The selection of logical operators, full-text search strategies, and keywords and Bibliographic Retrieval Service's Occurrence…

Harvard-MIT research program in short-lived radiopharmaceuticals. Final report

International Nuclear Information System (INIS)

Adelstein, S.J.

1995-02-01

The Harvard-MIT Research Program in Short-lived Radiopharmaceuticals was established in 1977 to foster interaction among groups working in radiopharmaceutical chemistry at Harvard Medical School, the Massachusetts Institute of Technology, and the Massachusetts General Hospital. To this was added a group at The Childrens Hospital. From these collaborations and building upon the special strengths of the participating individuals, laboratories and institutions, it was hoped that original approaches would be found for the design of new, clinically useful, radiolabeled compounds. The original thrust of this proposal included: (a) examination of the coordination chemistry of technetium as a basis for rational radiopharmaceutical design, (b) development of an ultrashort-lived radionuclide generator for the diagnosis of congenital heart disease in newborns, (c) synthesis of receptor-site-directed halopharmaceuticals, (d) improved facile labeling of complex molecules with positron-emitting radionuclides. The authors' 1986 proposal was oriented toward organs and disease, emphasizing radiolabeled agents that delineate specific functions and the distribution of receptors in brain, heart, and tumors. In 1989, they further refined their purposes and focused on two major aims: (a) synthesis and utilization of neutral technetium and rhenium complexes of high specific activity, and (b) development of new approaches to the radiolabeling of proteins, peptides, immunoglobulins, and their fragments. In 1992, the authors amended this proposal to concentrate their efforts on biologically active peptides and proteins for targeted radiodiagnosis and therapy

Harvard-MIT research program in short-lived radiopharmaceuticals. Final report

Energy Technology Data Exchange (ETDEWEB)

Adelstein, S.J. [Massachusetts Inst. of Tech., Cambridge, MA (United States). Office of Sponsored Programs

1995-02-01

The Harvard-MIT Research Program in Short-lived Radiopharmaceuticals was established in 1977 to foster interaction among groups working in radiopharmaceutical chemistry at Harvard Medical School, the Massachusetts Institute of Technology, and the Massachusetts General Hospital. To this was added a group at The Childrens Hospital. From these collaborations and building upon the special strengths of the participating individuals, laboratories and institutions, it was hoped that original approaches would be found for the design of new, clinically useful, radiolabeled compounds. The original thrust of this proposal included: (a) examination of the coordination chemistry of technetium as a basis for rational radiopharmaceutical design, (b) development of an ultrashort-lived radionuclide generator for the diagnosis of congenital heart disease in newborns, (c) synthesis of receptor-site-directed halopharmaceuticals, (d) improved facile labeling of complex molecules with positron-emitting radionuclides. The authors` 1986 proposal was oriented toward organs and disease, emphasizing radiolabeled agents that delineate specific functions and the distribution of receptors in brain, heart, and tumors. In 1989, they further refined their purposes and focused on two major aims: (a) synthesis and utilization of neutral technetium and rhenium complexes of high specific activity, and (b) development of new approaches to the radiolabeling of proteins, peptides, immunoglobulins, and their fragments. In 1992, the authors amended this proposal to concentrate their efforts on biologically active peptides and proteins for targeted radiodiagnosis and therapy.

Stratigraphy, age, and depositional setting of the Miocene Barstow Formation at Harvard Hill, central Mojave Desert, California

Science.gov (United States)

Leslie, Shannon R.; Miller, David M.; Wooden, Joseph L.; Vazquez, Jorge A.

2010-01-01

New detailed geologic mapping and geochronology of the Barstow Formation at Harvard Hill, 30 km east of Barstow, CA, help to constrain Miocene paleogeography and tectonics of the central Mojave Desert. A northern strand of the Quaternary ENE-striking, sinistral Manix fault divides the Barstow Formation at Harvard Hill into two distinct lithologic assemblages. Strata north of the fault consist of: a green rhyolitic tuff, informally named the Shamrock tuff; lacustrine sandstone; partially silicified thin-bedded to massive limestone; and alluvial sandstone to pebble conglomerate. Strata south of the fault consist of: lacustrine siltstone and sandstone; a rhyolitic tuff dated at 19.1 Ma (U-Pb); rock-avalanche breccia deposits; partially silicified well-bedded to massive limestone; and alluvial sandstone and conglomerate. Our U-Pb zircon dating of the Shamrock tuff by SHRIMP-RG yields a peak probability age of 18.7 ± 0.1 Ma. Distinctive outcrop characteristics, mineralogy, remanent magnetization, and zircon geochemistry (Th/U) suggest that the Shamrock tuff represents a lacustrine facies of the regionally extensive Peach Spring Tuff (PST). Here we compare zircon age and geochemical analyses from the Shamrock tuff with those of the PST at Stoddard Wash and provide new insight into the age of zircon crystallization in the PST rhyolite. Results of our field studies show that Miocene strata at Harvard Hill mostly accumulated in a lacustrine environment, although depositional environments varied from a relatively deep lake to a very shallow lake or even onshore setting. Rock-avalanche breccias and alluvial deposits near the base of the exposed section indicate proximity to a steep basin margin and detrital studies suggest a southern source for coarse-grained deposits; therefore, we may infer a southern basin-margin setting at Harvard Hill during the early Miocene. Our geochronology demonstrates that deposition of the Barstow Formation at Harvard Hill extended from before

"They Sweat for Science": The Harvard Fatigue Laboratory and Self-Experimentation in American Exercise Physiology.

Science.gov (United States)

Johnson, Andi

2015-08-01

In many scientific fields, the practice of self-experimentation waned over the course of the twentieth century. For exercise physiologists working today, however, the practice of self-experimentation is alive and well. This paper considers the role of the Harvard Fatigue Laboratory and its scientific director, D. Bruce Dill, in legitimizing the practice of self-experimentation in exercise physiology. Descriptions of self-experimentation are drawn from papers published by members of the Harvard Fatigue Lab. Attention is paid to the ethical and practical justifications for self-experimentation in both the lab and the field. Born out of the practical, immediate demands of fatigue protocols, self-experimentation performed the long-term, epistemological function of uniting physiological data across time and space, enabling researchers to contribute to a general human biology program.

The Harvard Catalyst Common Reciprocal IRB Reliance Agreement: an innovative approach to multisite IRB review and oversight.

Science.gov (United States)

Winkler, Sabune J; Witte, Elizabeth; Bierer, Barbara E

2015-02-01

Reduction of duplicative Institutional Review Board (IRB) review for multiinstitutional studies is a desirable goal to improve IRB efficiency while enhancing human subject protections. Here we describe the Harvard Catalyst Master Reciprocal Common IRB Reliance Agreement (MRA), a system that provides a legal framework for IRB reliance, with the potential to streamline IRB review processes and reduce administrative burden and barriers to collaborative, multiinstitutional research. The MRA respects the legal autonomy of the signatory institutions while offering a pathway to eliminate duplicative IRB review when appropriate. The Harvard Catalyst MRA provides a robust and flexible model for reciprocal reliance that is both adaptable and scalable. © 2014 Wiley Periodicals, Inc.

Psychiatry in the Harvard Medical School-Cambridge Integrated Clerkship: An Innovative, Year-Long Program

Science.gov (United States)

Griswold, Todd; Bullock, Christopher; Gaufberg, Elizabeth; Albanese, Mark; Bonilla, Pedro; Dvorak, Ramona; Epelbaum, Claudia; Givon, Lior; Kueppenbender, Karsten; Joseph, Robert; Boyd, J. Wesley; Shtasel, Derri

2012-01-01

Objective: The authors present what is to their knowledge the first description of a model for longitudinal third-year medical student psychiatry education. Method: A longitudinal, integrated psychiatric curriculum was developed, implemented, and sustained within the Harvard Medical School-Cambridge Integrated Clerkship. Curriculum elements…

The watershed years of 1958-1962 in the Harvard Pigeon Lab.

OpenAIRE

Catania, A Charles

2002-01-01

During the years 1958-1962, the final years of support by the National Science Foundation for B. F. Skinner's Pigeon Lab in Memorial Hall at Harvard University, 20 or so pigeon experiments (plus some with other organisms) ran concurrently 7 days a week. The research style emphasized experimental analyses, exploratory procedures, and the parametric exploration of variables. This reminiscence describes some features of the laboratory, the context within which it operated, and the activities of ...

Psychiatry in the Harvard Medical School-Cambridge Integrated Clerkship: an innovative, year-long program.

Science.gov (United States)

Griswold, Todd; Bullock, Christopher; Gaufberg, Elizabeth; Albanese, Mark; Bonilla, Pedro; Dvorak, Ramona; Epelbaum, Claudia; Givon, Lior; Kueppenbender, Karsten; Joseph, Robert; Boyd, J Wesley; Shtasel, Derri

2012-09-01

The authors present what is to their knowledge the first description of a model for longitudinal third-year medical student psychiatry education. A longitudinal, integrated psychiatric curriculum was developed, implemented, and sustained within the Harvard Medical School-Cambridge Integrated Clerkship. Curriculum elements include longitudinal mentoring by attending physicians in an outpatient psychiatry clinic, exposure to the major psychotherapies, psychopharmacology training, acute psychiatry "immersion" experiences, and a variety of clinical and didactic teaching sessions. The longitudinal psychiatry curriculum has been sustained for 8 years to-date, providing effective learning as demonstrated by OSCE scores, NBME shelf exam scores, written work, and observed clinical work. The percentage of students in this clerkship choosing psychiatry as a residency specialty is significantly greater than those in traditional clerkships at Harvard Medical School and greater than the U.S. average. Longitudinal integrated clerkship experiences are effective and sustainable; they offer particular strengths and opportunities for psychiatry education, and may influence student choice of specialty.

Harvard Catalyst | The Clinical Translational Science Center IND/IDE Consult Service: providing an IND/IDE consult service in a decentralized network of academic healthcare centers.

Science.gov (United States)

Kim, Min J; Winkler, Sabune J; Bierer, Barbara E; Wolf, Delia

2014-04-01

The Food and Drug Administration (FDA) regulations require sponsors of clinical investigations involving an investigational drug or device to submit an Investigational New Drug (IND) or Investigational Device Exemption (IDE) application. Strict adherence to applicable regulations is vital to the success of clinical research. Unlike most major pharmaceutical sponsors, investigator sponsors often do not fully appreciate their regulatory obligations nor have resources to ensure compliance. As a result they can place themselves and their institutions at risk. Nevertheless, investigator-initiated clinical trials are vital to the further development of innovative drugs, biologics, and medical devices. The IND/IDE Subcommittee under the Regulatory Knowledge and Support Program at Harvard Catalyst, The Harvard Clinical and Translational Science Center worked in collaboration with Harvard and Harvard affiliated institutions to create and launch an IND/IDE Consult Service in a decentralized network of collaborating Academic Healthcare Centers (AHC). The IND/IDE Consult Service offers expertise, resources, and shared experiences to assist sponsor-investigators and IRBs in meeting regulatory requirements for conducting and reviewing investigator-initiated IND/IDE studies. The scope of the services provided by the Harvard Catalyst IND/IDE Consult Service are described, including the specifics of the service, lessons learned, and challenges faced, in a scalable model that builds inter-institutional capacity. © 2014 Wiley Periodicals, Inc.

Harvard Catalyst | The Clinical Translational Science Center IND/IDE Consult Service: Providing an IND/IDE Consult Service in a Decentralized Network of Academic Healthcare Centers

Science.gov (United States)

Winkler, Sabune J.; Bierer, Barbara E.; Wolf, Delia

2014-01-01

Abstract The Food and Drug Administration (FDA) regulations require sponsors of clinical investigations involving an investigational drug or device to submit an Investigational New Drug (IND) or Investigational Device Exemption (IDE) application. Strict adherence to applicable regulations is vital to the success of clinical research. Unlike most major pharmaceutical sponsors, investigator sponsors often do not fully appreciate their regulatory obligations nor have resources to ensure compliance. As a result they can place themselves and their institutions at risk. Nevertheless, investigator‐initiated clinical trials are vital to the further development of innovative drugs, biologics, and medical devices. The IND/IDE Subcommittee under the Regulatory Knowledge and Support Program at Harvard Catalyst, The Harvard Clinical and Translational Science Center worked in collaboration with Harvard and Harvard affiliated institutions to create and launch an IND/IDE Consult Service in a decentralized network of collaborating Academic Healthcare Centers (AHC). The IND/IDE Consult Service offers expertise, resources, and shared experiences to assist sponsor‐investigators and IRBs in meeting regulatory requirements for conducting and reviewing investigator‐initiated IND/IDE studies. The scope of the services provided by the Harvard Catalyst IND/IDE Consult Service are described, including the specifics of the service, lessons learned, and challenges faced, in a scalable model that builds inter‐institutional capacity. PMID:24455986

Project PHaEDRA: Preserving Harvard's Early Data and Research in Astronomy

Science.gov (United States)

Bouquin, Daina; Frey, Katie; Henneken, Edwin; McEachern, Maria; McGrath, Alex; Guarracino, Daniel; Koch, Jennifer; Damon, James; Brownell, Eric; Smith-Zrull, Lindsay; Daina Bouquin

2018-01-01

Material originally produced during 19th and early 20th century by researchers at the Harvard College Observatory (HCO) was recently re-discovered in the HCO Astronomical Plate Stacks collection. This material helps represent the history of the HCO and acts as an irreplaceable primary source on the evolution of observation methods and astronomy as a science. The material is also relevant to the history of women in science as the collection contains logbooks and notebooks produced by the Harvard Computers, women who have come back into the spotlight due to the recent release of books like "The Glass Universe," "Rise of the Rocket Girls," and movies like "Hidden Figures". To ensure that this remarkable set of items is as accessible and useful as possible Wolbach Library, in collaboration with the SAO/NASA Astrophysics Data System (ADS) and others, is working to catalog, digitize, and preserve the entire collection. The material is also being transcribed by volunteers through the Smithsonian Transcription Center in DC. The transcription will allow the collection to be full-text searchable in ADS and for the notebooks to eventually be linked to their original source material: 500,000 glass plate photographs representing the first ever picture of the visible universe. The novel workflow of this distributed repository and the significance of the PHaEDRA collection both stand to support the research of future generations.

Stepping from Belgium to the United States and back: the conceptualization and impact of the Harvard Step Test, 1942-2012.

Science.gov (United States)

Vangrunderbeek, Hans; Delheye, Pascal

2013-06-01

This article examines the contribution of the Belgian-American exercise physiologist Lucien Brouha in developing the Harvard Step Test (HST) at the'pioneering Harvard Fatigue Laboratory (HFL) during the Second World War and provides a better understanding of the importance of transnational relations concerning scientific progress. Analysis of sources in the University Archives of the State University in Liege (Belgium), the Archives and Documentation Centre of the Sportimonium at Hofstade (Belgium), the Harvard Business School Archives at Baker Library (Cambridge, MA), the Harvard Medical School Archives at Countway Library (Cambridge, MA), and the Brouha and Shaler private family archives (Sutton, VT). The outbreak of the Second World War shifted research at the interdisciplinary HFL toward the field of military physiology and resulted in the transfer of Brouha from Belgium to the HFL. Brouha's personal and academic experiences made him the right man in the right place to develop the HST in 1942. The HST--which has celebrated its 70th anniversary--was of immediate academic and practical significance during and after the war. Brouha' s case demonstrates the importance of personal experiences, transnational relations, and interdisciplinary research settings for the establishment of scientific (sub)disciplines. Studying internal scientific evolutions in relation to personal and work experiences of "mobile" and therefore often "forgotten" researchers like Brouha is necessary to better understand and interpret evolutions in science and corresponding processes of academic and social mobility.

Harvard University: Green Loan Fund. Green Revolving Funds in Action: Case Study Series

Science.gov (United States)

Foley, Robert

2011-01-01

The Green Loan Fund at Harvard University has been an active source of capital for energy efficiency and waste reduction projects for almost a decade. This case study examines the revolving fund's history from its inception as a pilot project in the 1990s to its regeneration in the early 2000s to its current operations today. The green revolving…

The rise of pathophysiologic research in the United States: the role of two Harvard hospitals.

Science.gov (United States)

Tishler, Peter V

2013-01-01

Pathophysiologic research, the major approach to understanding and treating disease, was created in the 20th century, and two Harvard-affiliated hospitals, the Peter Bent Brigham Hospital and Boston City Hospital, played a key role in its development. After the Flexner Report of 1910, medical students were assigned clinical clerkships in teaching hospitals. Rockefeller-trained Francis Weld Peabody, who was committed to investigative, pathophysiologic research, was a critical leader in these efforts. At the Brigham, Harvard medical students observed patients closely and asked provocative questions about their diseases. Additionally, physicians returned from World War I with questions concerning the pathophysiology of wartime injuries. At the Boston City Hospital's new Thorndike Memorial Laboratory, Peabody fostered investigative question-based research by physicians. These physicians expanded pathophysiologic investigation from the 1920s. Post-war, Watson and Crick's formulation of the structure of DNA led shortly to modern molecular biology and new research approaches that are being furthered at the Boston Hospitals.

Melioration behaviour in the Harvard game is reduced by simplifying decision outcomes.

Science.gov (United States)

Stillwell, David J; Tunney, Richard J

2009-11-01

Self-control experiments have previously been highlighted as examples of suboptimal decision making. In one such experiment, the Harvard game, participants make repeated choices between two alternatives. One alternative has a higher immediate pay-off than the other, but with repeated choices results in a lower overall pay-off. Preference for the alternative with the higher immediate pay-off seems to be impulsive and will result in a failure to maximize pay-offs. We report an experiment that modifies the Harvard game, dividing the pay-off from each choice into two separate consequences-the immediate and the historic components. Choosing the alternative with the higher immediate pay-off ends the session prematurely, leading to a loss of opportunities to earn further pay-offs and ultimately to a reduced overall pay-off. This makes it easier for participants to learn the outcomes of their actions. It also provides the opportunity for a further test of normative decision making by means of one of its most specific and paradoxical predictions-that the truly rational agent should switch from self-control to impulsivity toward the end of the experimental sessions. The finding that participants maximize their expected utility by both overcoming impulsivity and learning to switch implies that melioration behaviour is not due to the lure of impulsivity, but due to the difficulty of learning which components are included in the pay-off schedules.

BIS impulsivity and acute nicotine exposure are associated with discounting global consequences in the Harvard game.

Science.gov (United States)

Hogarth, Lee; Stillwell, David J; Tunney, Richard J

2013-01-01

The Barratt Impulsivity Scale (BIS) provides a transdiagnostic marker for a number of psychiatric conditions and drug abuse, but the precise psychological trait(s) tapped by this questionnaire remain obscure. To address this, 51 smokers completed in counterbalanced order the BIS, a delay discounting task and a Harvard game that measured choice between a response that yielded a high immediate monetary payoff but decreased opportunity to earn money overall (local choice) versus a response that yielded a lower immediate payoff but afforded a greater opportunity to earn overall (global choice). Individual level of BIS impulsivity and self-elected smoking prior to the study were independently associated with increased preference for the local over the global choice in the Harvard game, but not delay discounting. BIS impulsivity and acute nicotine exposure reflect a bias in the governance of choice by immediate reward contingencies over global consequences, consistent with contemporary dual-process instrumental learning theories. Copyright © 2013 John Wiley & Sons, Ltd.

The Ideological Profile of Harvard University Press: Categorizing 494 Books Published 2000-2010

OpenAIRE

David Gordon; Per Nilsson

2011-01-01

The principal author surveyed all Harvard University Press titles published (in first edition) between 2000 and well into 2010, making 10+ years of publication, in the subject areas of Business & Economics, History, Philosophy, Political Science, and Sociology, as well as a residual of Law titles. A large number of titles were initially removed from the survey because the book title suggested little connection or platform for political ideology. After making these removals, 494 titles remaine...

The Multi-unit Assignment Problem: Theory and Evidence from Course Allocation at Harvard

OpenAIRE

Budish, Eric; Cantillon, Estelle

2010-01-01

This paper uses data consisting of students' strategically reported preferences and their underlying true preferences to study the course allocation mechanism used at Harvard Business School. We show that the mechanism is manipulable in theory, manipulated in practice, and that these manipulations cause meaningful welfare losses. However, we also find that ex-ante welfare is higher than under the strategyproof and ex-post efficient alternative, the Random Serial Dictatorship. We trace the poo...

Cytotoxicity Comparison of Harvard Zinc Phosphate Cement Versus Panavia F2 and Rely X Plus Resin Cements on Rat L929-fibroblasts.

Science.gov (United States)

Mahasti, Sahabi; Sattari, Mandana; Romoozi, Elham; Akbar-Zadeh Baghban, Alireza

2011-01-01

Resin cements, regardless of their biocompatibility, have been widely used in restorative dentistry during the recent years. These cements contain hydroxy ethyl methacrylate (HEMA) molecules which are claimed to penetrate into dentinal tubules and may affect dental pulp. Since tooth preparation for metal ceramic restorations involves a large surface of the tooth, cytotoxicity of these cements would be more important in fixed prosthodontic treatments. The purpose of this study was to compare the cytotoxicity of two resin cements (Panavia F2 and Rely X Plus) versus zinc phosphate cement (Harvard) using rat L929-fibroblasts in vitro. In this experimental study, ninety hollow glass cylinders (internal diameter 5-mm, height 2-mm) were made and divided into three groups. Each group was filled with one of three experimental cements; Harvard Zinc Phosphate cement, Panavia F2 resin cement and Rely X Plus resin cement. L929- Fibroblast were passaged and subsequently cultured in 6-well plates of 5×10(5) cells each. The culture medium was RPMI_ 1640. All samples were incubated in CO2. Using enzyme-linked immune-sorbent assay (ELISA) and (3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) (MTT) assay, the cytotoxicity of the cements was investigated at 1 hour, 24 hours and one week post exposure. Statistical analyses were performed via two-way ANOVA and honestly significant difference (HSD) Tukey tests. This study revealed significant differences between the three cements at the different time intervals. Harvard cement displayed the greatest cytotoxicity at all three intervals. After 1 hour Panavia F2 showed the next greatest cytotoxicity, but after 24-hours and oneweek intervals Rely X Plus showed the next greatest cytotoxicity. The results further showed that cytotoxicity decreased significantly in the Panavia F2 group with time (pHarvard cement group failed to showed no noticeable change in cytotoxicity with time. Although this study has limitations, it provides

Playing with Quantum Toys: Julian Schwinger's Measurement Algebra and the Material Culture of Quantum Mechanics Pedagogy at Harvard in the 1960s

Science.gov (United States)

Gauvin, Jean-François

2018-03-01

In the early 1960s, a PhD student in physics, Costas Papaliolios, designed a simple—and playful—system of Polaroid polarizer filters with a specific goal in mind: explaining the core principles behind Julian Schwinger's quantum mechanical measurement algebra, developed at Harvard in the late 1940s and based on the Stern-Gerlach experiment confirming the quantization of electron spin. Papaliolios dubbed his invention "quantum toys." This article looks at the origins and function of this amusing pedagogical device, which landed half a century later in the Collection of Historical Scientific Instruments at Harvard University. Rendering the abstract tangible was one of Papaliolios's demonstration tactics in reforming basic teaching of quantum mechanics. This article contends that Papaliolios's motivation in creating the quantum toys came from a renowned endeavor aimed, inter alia, at reforming high-school physics training in the United States: Harvard Project Physics. The pedagogical study of these quantum toys, finally, compels us to revisit the central role playful discovery performs in pedagogy, at all levels of training and in all fields of knowledge.

Cardiorespiratory endurance evaluation using heart rate analysis during ski simulator exercise and the Harvard step test in elementary school students.

Science.gov (United States)

Lee, Hyo Taek; Roh, Hyo Lyun; Kim, Yoon Sang

2016-01-01

[Purpose] Efficient management using exercise programs with various benefits should be provided by educational institutions for children in their growth phase. We analyzed the heart rates of children during ski simulator exercise and the Harvard step test to evaluate the cardiopulmonary endurance by calculating their post-exercise recovery rate. [Subjects and Methods] The subjects (n = 77) were categorized into a normal weight and an overweight/obesity group by body mass index. They performed each exercise for 3 minutes. The cardiorespiratory endurance was calculated using the Physical Efficiency Index formula. [Results] The ski simulator and Harvard step test showed that there was a significant difference in the heart rates of the 2 body mass index-based groups at each minute. The normal weight and the ski-simulator group had higher Physical Efficiency Index levels. [Conclusion] This study showed that a simulator exercise can produce a cumulative load even when performed at low intensity, and can be effectively utilized as exercise equipment since it resulted in higher Physical Efficiency Index levels than the Harvard step test. If schools can increase sport durability by stimulating students' interests, the ski simulator exercise can be used in programs designed to improve and strengthen students' physical fitness.

Evolution of the New Pathway curriculum at Harvard Medical School: the new integrated curriculum.

Science.gov (United States)

Dienstag, Jules L

2011-01-01

In 1985, Harvard Medical School adopted a "New Pathway" curriculum, based on active, adult learning through problem-based, faculty-facilitated small-group tutorials designed to promote lifelong skills of self-directed learning. Despite the successful integration of clinically relevant material in basic science courses, the New Pathway goals were confined primarily to the preclinical years. In addition, the shifting balance in the delivery of health care from inpatient to ambulatory settings limited the richness of clinical education in clinical clerkships, creating obstacles for faculty in their traditional roles as teachers. In 2006, Harvard Medical School adopted a more integrated curriculum based on four principles that emerged after half a decade of self-reflection and planning: (1) integrate the teaching of basic/population science and clinical medicine throughout the entire student experience; (2) reestablish meaningful and intensive faculty-student interactions and reengage the faculty; (3) develop a new model of clinical education that offers longitudinal continuity of patient experience, cross-disciplinary curriculum, faculty mentoring, and student evaluation; and (4) provide opportunities for all students to pursue an in-depth, faculty-mentored scholarly project. These principles of our New Integrated Curriculum reflect our vision for a curriculum that fosters a partnership between students and faculty in the pursuit of scholarship and leadership.

"Teaching Physics as one of the humanities": The history of (harvard) project Physics, 1961-1970

Science.gov (United States)

Meshoulam, David

In the United States after World War II, science had come to occupy a central place in the minds of policy makers, scientists, and the public. Negotiating different views between these groups proved a difficult task and spilled into debates over the role and scope of science education. To examine this process, this dissertation traces the history of Harvard Project Physics (HPP), a high-school physics curriculum from the 1960s that incorporated a humanistic and historical approach to teaching science. The narrative begins with the rise of General Education in the 1940s. Under the leadership of Harvard president James Conant, faculty at Harvard developed several Natural Science courses that connected science to history as a way to teach students about science and its relationship to culture. By the late 1950s this historical approach faced resistance from scientists who viewed it as misrepresenting their disciplines and called for students to learn specialized subject matter. With the support of the National Science Foundation (NSF), in the early 1960s scientists' vision of science education emerged in high-school classrooms across the country. By the mid 1960s, with the passage of the Civil Rights Act, the Elementary and Secondary Education Act, and the Daddario Amendment to the NSF, the political and education landscape began to change. These laws transformed the goals of two of the NSF and the Office of Education (USOE). These organizations faced demands to work together to develop projects that would speak to domestic concerns over equity and diversity. Their first joint educational venture was HPP. In order to succeed, HPP had to speak to the needs of disciplinary-minded scientists at the NSF, equity-minded educators at the USOE, and results-focused politicians in Congress. This work argues that HPP succeeded because it met the needs of these various stakeholders regarding the roles of science and education in American society.

Study of neutron hole states in 207206205Pb with the (3He,α) reaction at 110MeV. First tests in (d,t) reaction of the Orsay synchrocyclotron spectrometric line

International Nuclear Information System (INIS)

Guillot, J.

1979-01-01

Neutron hole states in the 207 Pb, 206 Pb, 205 Pb isotopes were studied up to 25 MeV excitation energy using the ( 3 He,α) reaction at 100MeV incident energy, with 100 keV energy resolution. Angular distributions for the low-lying levels and inner hole states have been analyzed with DWBA and spectroscopic factors extracted for 1 > 3 levels. Missing strengths for the first levels from 1i13/2 and 1h9/2 orbits are found in the bump located around 5MeV excitation energy. The fragmented bump observed around 8MeV excitation energy is attributed to 1h11/2 pick-up with 45% of the sum-rule limit. Finally, the structure extending up to 21 MeV excitation energy is attributed to 1g7/2+1g9/2 pick-up with 80% of the total strength. In 207 Pb, the four first isobaric analog states Tsub(>) = 45/2 are identifierd around 20MeV excitation energy. The second part of this work presents the first tests in (d,t) reaction at 108 MeV on 90 Zr and 208 Pb using the achromatic line of the Orsay synchrocyclotron [fr

Design and Implementation of the Harvard Fellowship in Patient Safety and Quality.

Science.gov (United States)

Gandhi, Tejal K; Abookire, Susan A; Kachalia, Allen; Sands, Kenneth; Mort, Elizabeth; Bommarito, Grace; Gagne, Jane; Sato, Luke; Weingart, Saul N

2016-01-01

The Harvard Fellowship in Patient Safety and Quality is a 2-year physician-oriented training program with a strong operational orientation, embedding trainees in the quality departments of participating hospitals. It also integrates didactic and experiential learning and offers the option of obtaining a master's degree in public health. The program focuses on methodologically rigorous improvement and measurement, with an emphasis on the development and implementation of innovative practice. The operational orientation is intended to foster the professional development of future quality and safety leaders. The purpose of this article is to describe the design and development of the fellowship. © The Author(s) 2014.

Measurements of canopy chemistry with 1992 AVIRIS data at Blackhawk Island and Harvard Forest

Science.gov (United States)

Martin, Mary E.; Aber, John D.

1993-01-01

The research described in this paper was designed to determine if high spectral resolution imaging spectrometer data can be used to measure the chemical composition of forest foliage, specifically nitrogen and lignin concentration. Information about the chemical composition of forest canopies can be used to determine nutrient cycling rates and carbon balances in forest ecosystems. This paper will describe the results relating data from the Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) to field measured canopy chemistry at Blackhawk Island, WI and Harvard Forest, MA.

Root phenology at Harvard Forest and beyond

Science.gov (United States)

Abramoff, R. Z.; Finzi, A.

2013-12-01

Roots are hidden from view and heterogeneously distributed making them difficult to study in situ. As a result, the causes and timing of root production are not well understood. Researchers have long assumed that above and belowground phenology is synchronous; for example, most parameterizations of belowground carbon allocation in terrestrial biosphere models are based on allometry and represent a fixed fraction of net C uptake. However, using results from metaanalysis as well as empirical data from oak and hemlock stands at Harvard Forest, we show that synchronous root and shoot growth is the exception rather than the rule. We collected root and shoot phenology measurements from studies across four biomes (boreal, temperate, Mediterranean, and subtropical). General patterns of root phenology varied widely with 1-5 production peaks in a growing season. Surprisingly, in 9 out of the 15 studies, the first root production peak was not the largest peak. In the majority of cases maximum shoot production occurred before root production (Offset>0 in 32 out of 47 plant sample means). The number of days offset between maximum root and shoot growth was negatively correlated with median annual temperature and therefore differs significantly across biomes (ANOVA, F3,43=9.47, pGrowth form (woody or herbaceous) also influenced the relative timing of root and shoot growth. Woody plants had a larger range of days between root and shoot growth peaks as well as a greater number of growth peaks. To explore the range of phenological relationships within woody plants in the temperate biome, we focused on above and belowground phenology in two common northeastern tree species, Quercus rubra and Tsuga canadensis. Greenness index, rate of stem growth, root production and nonstructural carbohydrate content were measured beginning in April 2012 through August 2013 at the Harvard Forest in Petersham, MA, USA. Greenness and stem growth were highest in late May and early June with one clear

The Sociology of the Deceased Harvard Medical Unit at Boston City Hospital.

Science.gov (United States)

Tishler, Peter V

2015-12-01

Many graduates of the Harvard Medical Unit (HMU) at Boston City Hospital, in either the clinical training/residency program or the research program at the Thorndike Memorial Laboratory, contributed in major ways to the HMU and constantly relived their HMU experiences. The HMU staff physicians, descending from founder and mentor physicians Francis W. Peabody, Soma Weiss, and George R. Minot, were dedicated to the teaching, development, and leadership of its clinical and research trainees, whose confidence and dedication to patient care as a result of their mentorship led many to lifelong achievements as clinicians, teachers, and mentors. Their experience also led to a lifelong love of the HMU (despite its loss), camaraderie, happiness, and intense friendships with their associates.

French Norms for the Harvard Group Scale of Hypnotic Susceptibility, Form A.

Science.gov (United States)

Anlló, Hernán; Becchio, Jean; Sackur, Jérôme

2017-01-01

The authors present French norms for the Harvard Group Scale of Hypnotic Susceptibility, Form A (HGSHS:A). They administered an adapted translation of Shor and Orne's original text (1962) to a group of 126 paid volunteers. Participants also rated their own responses following our translation of Kihlstrom's Scale of Involuntariness (2006). Item pass rates, score distributions, and reliability were calculated and compared with several other reference samples. Analyses show that the present French norms are congruous with the reference samples. Interestingly, the passing rate for some items drops significantly if "entirely voluntary" responses (as identified by Kihlstrom's scale) are scored as "fail." Copies of the translated scales and response booklet are available online.

Excuse Me. Do You Speak Digital?: Harvard's John Palfrey Explores What It's Like to Be a Digital Native

Science.gov (United States)

Harris, Christopher

2009-01-01

John Palfrey is one busy guy, with an impressive gig. In 2008, he was named the Henry N. Ess III Professor of Law and Vice Dean for Library and Information Resources at Harvard Law School. And when he's not teaching courses on intellectual property and Internet law, there's a good chance he's overseeing the L school's research library. Palfrey,…

Library Technology and Architecture; Report of a Conference Held at the Harvard Graduate School of Education, February 9, 1967.

Science.gov (United States)

Harvard Univ., Cambridge, MA. Graduate School of Education.

The purpose of the conference was to investigate the implications of new technologies for library architecture and to use the findings in planning new Library Research Facility for the Harvard Graduate School of Education. The first half of this document consists of reports prepared by six consultants on such topics as microforms, computers,…

The Sociology of the Deceased Harvard Medical Unit at Boston City Hospital

Science.gov (United States)

Tishler, Peter V.

2015-01-01

Many graduates of the Harvard Medical Unit (HMU) at Boston City Hospital, in either the clinical training/residency program or the research program at the Thorndike Memorial Laboratory, contributed in major ways to the HMU and constantly relived their HMU experiences. The HMU staff physicians, descending from founder and mentor physicians Francis W. Peabody, Soma Weiss, and George R. Minot, were dedicated to the teaching, development, and leadership of its clinical and research trainees, whose confidence and dedication to patient care as a result of their mentorship led many to lifelong achievements as clinicians, teachers, and mentors. Their experience also led to a lifelong love of the HMU (despite its loss), camaraderie, happiness, and intense friendships with their associates. PMID:26604868

Hungarian norms for the Harvard Group Scale of Hypnotic Susceptibility, Form A.

Science.gov (United States)

Költő, András; Gősi-Greguss, Anna C; Varga, Katalin; Bányai, Éva I

2015-01-01

Hungarian norms for the Harvard Group Scale of Hypnotic Susceptibility, Form A (HGSHS:A) are presented. The Hungarian translation of the HGSHS:A was administered under standard conditions to 434 participants (190 males, 244 females) of several professions. In addition to the traditional self-scoring, hypnotic behavior was also recorded by trained observers. Female participants proved to be more hypnotizable than males and so were psychology students and professionals as compared to nonpsychologists. Hypnotizability varied across different group sizes. The normative data-including means, standard deviations, and indicators of reliability-are comparable with previously published results. The authors conclude that measuring observer-scores increases the ecological validity of the scale. The Hungarian version of the HGSHS:A seems to be a reliable and valid measure of hypnotizability.

Findings from the Harvard Medical School Cambridge Integrated Clerkship, a Year-Long Longitudinal Psychiatry Experience.

Science.gov (United States)

Cheng, Elisa; Hirsh, David; Gaufberg, Elizabeth; Griswold, Todd; Wesley Boyd, J

2018-06-01

The Harvard Medical School Cambridge Integrated Clerkship is a longitudinal integrated clerkship that has provided an alternative clinical model for medical education in psychiatry since its inception in 2004. This study was undertaken in an effort to better understand the student experience of the Cambridge Integrated Clerkship and how it may have impacted students' perceptions of and interest in psychiatry, as well as performance. Qualitative surveys were sent via e-mail to the first 11 student cohorts who had completed the Cambridge Integrated Clerkship (from 2004 to 2014) and for whom we had e-mail addresses (N = 100), and the free-text responses were coded thematically. All available standardized scoring data and residency match data for Cambridge Integrated Clerkship graduates were obtained. From 2006 to 2014, 12 out of 73 Cambridge Integrated Clerkship students who entered the match chose a psychiatry residency (16.4%), four times more than students in traditional clerkships at Harvard Medical School (3.8% of 1355 students) or the national average (4.1% of 146,066 US applicants). Thirty of the 100 surveyed Cambridge Integrated Clerkship graduates (30%) responded to the qualitative survey with free-text remarks on a number of themes. Cambridge Integrated Clerkship students compared positively to their classmates in terms of standardized test performance. Their fourfold higher match rate into psychiatry compared to other students raises intriguing questions as to what role a longitudinal clerkship might have played in developing interest in psychiatry as a career.

UBV(RI)sub(c) photometry of some standard sequences in the Harvard F regions and in the Magellanic Clouds

International Nuclear Information System (INIS)

Menzies, J.W.; Laing, J.D.

1988-01-01

This paper presents the results of a photometric programme aimed at improving the UBV(RI)sub(c) standard sequences in the Harvard F regions and in the Small and Large Magellanic Clouds. Magnitudes and colours are given for 99 stars, and they are compared with the current values which were obtained or compiled by a previous author. (author)

Norms of German adolescents for the Harvard Group Scale of Hypnotic Susceptibility, Form A.

Science.gov (United States)

Peter, Burkhard; Geiger, Emilia; Prade, Tanja; Vogel, Sarah; Piesbergen, Christoph

2015-01-01

The Harvard Group Scale of Hypnotic Susceptibility, Form A (HGSHS:A) has not been explicitly tested on an adolescent population. In this study, the German version of the HGSHS:A was administered to 99 German adolescents aged 15 to 19. In contrast to other studies, the gender distribution was relatively balanced: 57% female and 43% male. Results were comparable to 14 earlier studies with regard to distribution, mean, and standard deviation. Some peculiarities in contrast to the 14 previous studies are pointed out. It is concluded that the HGSHS:A can be used as a valid and reliable instrument to measure hypnotic suggestibility in adolescent samples.

Economics Case Study: Harvard Business School Pedagogy Techniques: From Teaching Entrepreneurship to Influencing Business Policy through Research

OpenAIRE

Mamoon, Dawood

2017-01-01

Abstract. The case study explains the need for social entrepreneurship while remaining in the premise of mainstream economics. A detailed discussion is carried out on the vulnerabilities of economic policy making that has led to some of the new initiatives at Harvard Business School to promote such pedagogy practices at Business Schools that may eventually influence national and international policy making to the benefit of the society and not only the economies of developed and developing co...

Comparison of Stem Map Developed from Crown Geometry Allometry Linked Census Data to Airborne and Terrestrial Lidar at Harvard Forest, MA

Science.gov (United States)

Sullivan, F.; Palace, M. W.; Ducey, M. J.; David, O.; Cook, B. D.; Lepine, L. C.

2014-12-01

Harvard Forest in Petersham, MA, USA is the location of one of the temperate forest plots established by the Center for Tropical Forest Science (CTFS) as a joint effort with Harvard Forest and the Smithsonian Institute's Forest Global Earth Observatory (ForestGEO) to characterize ecosystem processes and forest dynamics. Census of a 35 ha plot on Prospect Hill was completed during the winter of 2014 by researchers at Harvard Forest. Census data were collected according to CTFS protocol; measured variables included species, stem diameter, and relative X-Y locations. Airborne lidar data were collected over the censused plot using the high spatial resolution Goddard LiDAR, Hyperspectral, and Thermal sensor package (G-LiHT) during June 2012. As part of a separate study, 39 variable radius plots (VRPs) were randomly located and sampled within and throughout the Prospect Hill CTFS/ForestGEO plot during September and October 2013. On VRPs, biometric properties of trees were sampled, including species, stem diameter, total height, crown base height, crown radii, and relative location to plot centers using a 20 Basal Area Factor prism. In addition, a terrestrial-based lidar scanner was used to collect one lidar scan at plot center for 38 of the 39 VRPs. Leveraging allometric equations of crown geometry and tree height developed from 374 trees and 16 different species sampled on 39 VRPs, a 3-dimensional stem map will be created using the Harvard Forest ForestGEO Prospect Hill census. Vertical and horizontal structure of 3d field-based stem maps will be compared to terrestrial and airborne lidar scan data. Furthermore, to assess the quality of allometric equations, a 2d canopy height raster of the field-based stem map will be compared to a G-LiHT derived canopy height model for the 35 ha census plot. Our automated crown delineation methods will be applied to the 2d representation of the census stem map and the G-LiHT canopy height model. For future work related to this study

The Harvard experiment on OSO-6 - Instrumentation, calibration, operation, and description of observations.

Science.gov (United States)

Huber, M. C. E.; Dupree, A. K.; Goldberg, L.; Parkinson, W. H.; Reeves, E. M.; Withbroe, G. L.; Noyes, R. W.

1973-01-01

The Harvard experiment carried by OSO-6 was an extreme-ultraviolet (EUV) spectrometer-spectroheliometer with a wavelength range of 285 to 1385 A, a spatial and spectral bandwidth of 35 x 35(arc sec) squared and 3 A, respectively. The instrument acquired data that have been deposited with the National Space Science Data Center and World Data Center A at the Goddard Space Flight Center in Greenbelt, Maryland, and are now available in their entirety to the scientific community. Aspects of the experiment that are relevant to potential users of the data are described - namely, instrument configuration and parameters, laboratory and inflight calibrations, as well as operational capabilities and procedures. The observations obtained are reported, and the nature, number, and dates of observation, where relevant, are listed.

Limited effect of ozone reductions on the 20-year photosynthesis trend at Harvard forest.

Science.gov (United States)

Yue, Xu; Keenan, Trevor F; Munger, William; Unger, Nadine

2016-11-01

Ozone (O 3 ) damage to leaves can reduce plant photosynthesis, which suggests that declines in ambient O 3 concentrations ([O 3 ]) in the United States may have helped increase gross primary production (GPP) in recent decades. Here, we assess the effect of long-term changes in ambient [O 3 ] using 20 years of observations at Harvard forest. Using artificial neural networks, we found that the effect of the inclusion of [O 3 ] as a predictor was slight, and independent of O 3 concentrations, which suggests limited high-frequency O 3 inhibition of GPP at this site. Simulations with a terrestrial biosphere model, however, suggest an average long-term O 3 inhibition of 10.4% for 1992-2011. A decline of [O 3 ] over the measurement period resulted in moderate predicted GPP trends of 0.02-0.04 μmol C m -2  s -1  yr -1 , which is negligible relative to the total observed GPP trend of 0.41 μmol C m -2  s -1  yr -1 . A similar conclusion is achieved with the widely used AOT40 metric. Combined, our results suggest that ozone reductions at Harvard forest are unlikely to have had a large impact on the photosynthesis trend over the past 20 years. Such limited effects are mainly related to the slow responses of photosynthesis to changes in [O 3 ]. Furthermore, we estimate that 40% of photosynthesis happens in the shade, where stomatal conductance and thus [O 3 ] deposition is lower than for sunlit leaves. This portion of GPP remains unaffected by [O 3 ], thus helping to buffer the changes of total photosynthesis due to varied [O 3 ]. Our analyses suggest that current ozone reductions, although significant, cannot substantially alleviate the damages to forest ecosystems. © 2016 John Wiley & Sons Ltd.

Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study

Science.gov (United States)

Ding, Hongliu; Sarokhan, Alison K.; Roderick, Sarah S.; Bakshi, Rachit; Maher, Nancy E.; Ashourian, Paymon; Kan, Caroline G.; Chang, Sunny; Santarlasci, Andrea; Swords, Kyleen E.; Ravina, Bernard M.; Hayes, Michael T.; Sohur, U. Shivraj; Wills, Anne-Marie; Flaherty, Alice W.; Unni, Vivek K.; Hung, Albert Y.; Selkoe, Dennis J.; Schwarzschild, Michael A.; Schlossmacher, Michael G.; Sudarsky, Lewis R.; Growdon, John H.; Ivinson, Adrian J.; Hyman, Bradley T.; Scherzer, Clemens R.

2011-01-01

Background Mutations in the α-synuclein gene (SNCA) cause autosomal dominant forms of Parkinson’s disease, but the substantial risk conferred by this locus to the common sporadic disease has only recently emerged from genome-wide association studies. Methods Here we genotyped a prioritized non-coding variant in SNCA intron-4 in 344 patients with Parkinson’s and 275 controls from the longitudinal Harvard NeuroDiscovery Center Biomarker Study. Results The common minor allele of rs2736990 was associated with elevated disease susceptibility (odds ratio = 1.40, P value = 0.0032). Conclusions This result increases confidence in the notion that in many clinically well-characterized patients genetic variation in SNCA contributes to “sporadic” disease. PMID:21953863

Harvard Personal Genome Project: lessons from participatory public research

Science.gov (United States)

2014-01-01

Background Since its initiation in 2005, the Harvard Personal Genome Project has enrolled thousands of volunteers interested in publicly sharing their genome, health and trait data. Because these data are highly identifiable, we use an ‘open consent’ framework that purposefully excludes promises about privacy and requires participants to demonstrate comprehension prior to enrollment. Discussion Our model of non-anonymous, public genomes has led us to a highly participatory model of researcher-participant communication and interaction. The participants, who are highly committed volunteers, self-pursue and donate research-relevant datasets, and are actively engaged in conversations with both our staff and other Personal Genome Project participants. We have quantitatively assessed these communications and donations, and report our experiences with returning research-grade whole genome data to participants. We also observe some of the community growth and discussion that has occurred related to our project. Summary We find that public non-anonymous data is valuable and leads to a participatory research model, which we encourage others to consider. The implementation of this model is greatly facilitated by web-based tools and methods and participant education. Project results are long-term proactive participant involvement and the growth of a community that benefits both researchers and participants. PMID:24713084

Harvard Personal Genome Project: lessons from participatory public research.

Science.gov (United States)

Ball, Madeleine P; Bobe, Jason R; Chou, Michael F; Clegg, Tom; Estep, Preston W; Lunshof, Jeantine E; Vandewege, Ward; Zaranek, Alexander; Church, George M

2014-02-28

Since its initiation in 2005, the Harvard Personal Genome Project has enrolled thousands of volunteers interested in publicly sharing their genome, health and trait data. Because these data are highly identifiable, we use an 'open consent' framework that purposefully excludes promises about privacy and requires participants to demonstrate comprehension prior to enrollment. Our model of non-anonymous, public genomes has led us to a highly participatory model of researcher-participant communication and interaction. The participants, who are highly committed volunteers, self-pursue and donate research-relevant datasets, and are actively engaged in conversations with both our staff and other Personal Genome Project participants. We have quantitatively assessed these communications and donations, and report our experiences with returning research-grade whole genome data to participants. We also observe some of the community growth and discussion that has occurred related to our project. We find that public non-anonymous data is valuable and leads to a participatory research model, which we encourage others to consider. The implementation of this model is greatly facilitated by web-based tools and methods and participant education. Project results are long-term proactive participant involvement and the growth of a community that benefits both researchers and participants.

Is detection of adverse events affected by record review methodology? an evaluation of the "Harvard Medical Practice Study" method and the "Global Trigger Tool".

Science.gov (United States)

Unbeck, Maria; Schildmeijer, Kristina; Henriksson, Peter; Jürgensen, Urban; Muren, Olav; Nilsson, Lena; Pukk Härenstam, Karin

2013-04-15

There has been a theoretical debate as to which retrospective record review method is the most valid, reliable, cost efficient and feasible for detecting adverse events. The aim of the present study was to evaluate the feasibility and capability of two common retrospective record review methods, the "Harvard Medical Practice Study" method and the "Global Trigger Tool" in detecting adverse events in adult orthopaedic inpatients. We performed a three-stage structured retrospective record review process in a random sample of 350 orthopaedic admissions during 2009 at a Swedish university hospital. Two teams comprised each of a registered nurse and two physicians were assigned, one to each method. All records were primarily reviewed by registered nurses. Records containing a potential adverse event were forwarded to physicians for review in stage 2. Physicians made an independent review regarding, for example, healthcare causation, preventability and severity. In the third review stage all adverse events that were found with the two methods together were compared and all discrepancies after review stage 2 were analysed. Events that had not been identified by one of the methods in the first two review stages were reviewed by the respective physicians. Altogether, 160 different adverse events were identified in 105 (30.0%) of the 350 records with both methods combined. The "Harvard Medical Practice Study" method identified 155 of the 160 (96.9%, 95% CI: 92.9-99.0) adverse events in 104 (29.7%) records compared with 137 (85.6%, 95% CI: 79.2-90.7) adverse events in 98 (28.0%) records using the "Global Trigger Tool". Adverse events "causing harm without permanent disability" accounted for most of the observed difference. The overall positive predictive value for criteria and triggers using the "Harvard Medical Practice Study" method and the "Global Trigger Tool" was 40.3% and 30.4%, respectively. More adverse events were identified using the "Harvard Medical Practice Study

Educational outcomes of the Harvard Medical School-Cambridge integrated clerkship: a way forward for medical education.

Science.gov (United States)

Hirsh, David; Gaufberg, Elizabeth; Ogur, Barbara; Cohen, Pieter; Krupat, Edward; Cox, Malcolm; Pelletier, Stephen; Bor, David

2012-05-01

The authors report data from the Harvard Medical School-Cambridge Integrated Clerkship (CIC), a model of medical education in which students' entire third year consists of a longitudinal, integrated curriculum. The authors compare the knowledge, skills, and attitudes of students completing the CIC with those of students completing traditional third-year clerkships. The authors compared 27 students completing the first three years of the CIC (2004-2007) with 45 students completing clerkships at other Harvard teaching hospitals during the same period. At baseline, no significant between-group differences existed (Medical College Admission Test and Step 1 scores, second-year objective structured clinical examination [OSCE] performance, attitudes toward patient-centered care, and plans for future practice) in any year. The authors compared students' National Board of Medical Examiners Subject and Step 2 Clinical Knowledge scores, OSCE performance, perceptions of the learning environment, and attitudes toward patient-centeredness. CIC students performed as well as or better than their traditionally trained peers on measures of content knowledge and clinical skills. CIC students expressed higher satisfaction with the learning environment, more confidence in dealing with numerous domains of patient care, and a stronger sense of patient-centeredness. CIC students are at least as well as and in several ways better prepared than their peers. CIC students also demonstrate richer perspectives on the course of illness, more insight into social determinants of illness and recovery, and increased commitment to patients. These data suggest that longitudinal integrated clerkships offer students important intellectual, professional, and personal benefits.

Tropical veterinary parasites at Harvard University's Museum of Comparative Zoology.

Science.gov (United States)

Conn, David Bruce

2008-12-01

Tropical veterinary parasites have been maintained by the Museum of Comparative Zoology (MCZ) at Harvard University since the mid 1800s. Most of these are maintained by the Department of Invertebrate Zoology, but many vectors and intermediate hosts are maintained by the Departments of Entomology and Malacology. The largest collections are of avian and mammalian ticks (Acarina) that are important as both parasites and vectors. Nematodes are second in numbers, followed by cestodes, trematodes, and several minor helminth groups, crustacean parasites of fish, and protozoan parasites of various hosts. The MCZ directed or participated in several major expeditions to tropical areas around the globe in the early 1900s. Many of these expeditions focused on human parasites, but hundreds of veterinary and zoonotic parasites were also collected from these and numerous, smaller, tropical expeditions. Host sources include companion animals, livestock, laboratory species, domestic fowl, reptiles, amphibians, exotics/zoo animals, commercially important fishes, and other wildlife. Specimens are curated, either fixed whole in vials or mounted on slides as whole mounts or histopathological sections. The primary emphasis of MCZ's current work with tropical veterinary parasites is on voucher specimens from epidemiological, experimental, and clinical research.

Long-term trends of changes in pine and oak foliar nitrogen metabolism in response to chronic nitrogen amendments at Harvard Forest, MA

Science.gov (United States)

Rakesh Minocha; Swathi A. Turlapati; Stephanie Long; William H. McDowell; Subhash C. Minocha

2015-01-01

We evaluated the long-term (1995-2008) trends in foliar and sapwood metabolism, soil solution chemistry and tree mortality rates in response to chronic nitrogen (N) additions to pine and hardwood stands at the Harvard Forest Long Term Ecological Research (LTER) site. Common stress-related metabolites like polyamines (PAs), free amino acids (AAs) and inorganic elements...

[Simulation of water and carbon fluxes in harvard forest area based on data assimilation method].

Science.gov (United States)

Zhang, Ting-Long; Sun, Rui; Zhang, Rong-Hua; Zhang, Lei

2013-10-01

Model simulation and in situ observation are the two most important means in studying the water and carbon cycles of terrestrial ecosystems, but have their own advantages and shortcomings. To combine these two means would help to reflect the dynamic changes of ecosystem water and carbon fluxes more accurately. Data assimilation provides an effective way to integrate the model simulation and in situ observation. Based on the observation data from the Harvard Forest Environmental Monitoring Site (EMS), and by using ensemble Kalman Filter algorithm, this paper assimilated the field measured LAI and remote sensing LAI into the Biome-BGC model to simulate the water and carbon fluxes in Harvard forest area. As compared with the original model simulated without data assimilation, the improved Biome-BGC model with the assimilation of the field measured LAI in 1998, 1999, and 2006 increased the coefficient of determination R2 between model simulation and flux observation for the net ecosystem exchange (NEE) and evapotranspiration by 8.4% and 10.6%, decreased the sum of absolute error (SAE) and root mean square error (RMSE) of NEE by 17.7% and 21.2%, and decreased the SAE and RMSE of the evapotranspiration by 26. 8% and 28.3%, respectively. After assimilated the MODIS LAI products of 2000-2004 into the improved Biome-BGC model, the R2 between simulated and observed results of NEE and evapotranspiration was increased by 7.8% and 4.7%, the SAE and RMSE of NEE were decreased by 21.9% and 26.3%, and the SAE and RMSE of evapotranspiration were decreased by 24.5% and 25.5%, respectively. It was suggested that the simulation accuracy of ecosystem water and carbon fluxes could be effectively improved if the field measured LAI or remote sensing LAI was integrated into the model.

Models of the quiet and active solar atmosphere from Harvard OSO data.

Science.gov (United States)

Noyes, R. W.

1971-01-01

Review of some Harvard Observatory programs aimed at defining the physical conditions in quiet and active solar regions on the basis of data obtained from the OSO-IV and OSO-VI spacecraft. The spectral range covered is from 300 A to 1400 A. This spectral range consists of emission lines and continua from abundant elements such as hydrogen, helium, carbon, nitrogen, oxygen, silicon, magnesium, aluminum, neon, iron, and calcium in various ionization states ranging from neutral to 15 times ionized. The structure is discussed of the quiet solar atmosphere as deduced from center-to-limb behavior of spectral lines and continua formed in the chromosphere and corona. In reviewing investigations of solar active regions, it is shown that the structure of these regions varies in a complicated manner from point to point. The local structure is influenced by factors such as the magnetic field configuration within the active region and the age or evolutionary state of the region.

Producing physician-scientists: a survey of graduates from the Harvard--MIT Program in Health Sciences and Technology.

Science.gov (United States)

Wilkerson, L; Abelmann, W H

1993-03-01

The Harvard-MIT Program in Health Sciences and Technology (HST) is a flexible, preclinical curriculum, taught by members of the faculties of both Harvard University and the Massachusetts Institute of Technology, that stresses a rigorous, scientific, quantitative approach, small classes (usually fewer than 50 students), and student-faculty interaction. The program is aimed at students with strong backgrounds in quantitative and biological sciences who are interested in careers as physician-scientists. The first 234 students of the program, who graduated between 1975 and 1985, were asked to participate in a 1990 follow-up study by completing a four-page questionnaire and submitting curricula vitae and lists of publications, if available. Data were analyzed quantitatively and qualitatively. Of the 234 graduates, 211 (90%) responded. Sixty-three (30%) had received both MD and PhD degrees. The graduates were twice as likely to describe their primary professional roles as academic than as clinical practice; 94 held full-time faculty positions at 50 medical schools. The 154 (73%) in research spent an average of 51% of their time on this activity. According to the 179 graduates (85%) who stated that they would choose HST again, the most frequently mentioned reasons were the quantitative approach that emphasized integration of basic science and clinical practice (49%) and the small class size (37%). The HST MD curriculum, with its emphasis on basic science and research experience, has been successful in preparing carefully selected students for careers as physician-scientists, without necessarily requiring the completion of a PhD degree.

The Transgenic RNAi Project at Harvard Medical School: Resources and Validation.

Science.gov (United States)

Perkins, Lizabeth A; Holderbaum, Laura; Tao, Rong; Hu, Yanhui; Sopko, Richelle; McCall, Kim; Yang-Zhou, Donghui; Flockhart, Ian; Binari, Richard; Shim, Hye-Seok; Miller, Audrey; Housden, Amy; Foos, Marianna; Randkelv, Sakara; Kelley, Colleen; Namgyal, Pema; Villalta, Christians; Liu, Lu-Ping; Jiang, Xia; Huan-Huan, Qiao; Wang, Xia; Fujiyama, Asao; Toyoda, Atsushi; Ayers, Kathleen; Blum, Allison; Czech, Benjamin; Neumuller, Ralph; Yan, Dong; Cavallaro, Amanda; Hibbard, Karen; Hall, Don; Cooley, Lynn; Hannon, Gregory J; Lehmann, Ruth; Parks, Annette; Mohr, Stephanie E; Ueda, Ryu; Kondo, Shu; Ni, Jian-Quan; Perrimon, Norbert

2015-11-01

To facilitate large-scale functional studies in Drosophila, the Drosophila Transgenic RNAi Project (TRiP) at Harvard Medical School (HMS) was established along with several goals: developing efficient vectors for RNAi that work in all tissues, generating a genome-scale collection of RNAi stocks with input from the community, distributing the lines as they are generated through existing stock centers, validating as many lines as possible using RT-qPCR and phenotypic analyses, and developing tools and web resources for identifying RNAi lines and retrieving existing information on their quality. With these goals in mind, here we describe in detail the various tools we developed and the status of the collection, which is currently composed of 11,491 lines and covering 71% of Drosophila genes. Data on the characterization of the lines either by RT-qPCR or phenotype is available on a dedicated website, the RNAi Stock Validation and Phenotypes Project (RSVP, http://www.flyrnai.org/RSVP.html), and stocks are available from three stock centers, the Bloomington Drosophila Stock Center (United States), National Institute of Genetics (Japan), and TsingHua Fly Center (China). Copyright © 2015 by the Genetics Society of America.

The Transgenic RNAi Project at Harvard Medical School: Resources and Validation

Science.gov (United States)

Perkins, Lizabeth A.; Holderbaum, Laura; Tao, Rong; Hu, Yanhui; Sopko, Richelle; McCall, Kim; Yang-Zhou, Donghui; Flockhart, Ian; Binari, Richard; Shim, Hye-Seok; Miller, Audrey; Housden, Amy; Foos, Marianna; Randkelv, Sakara; Kelley, Colleen; Namgyal, Pema; Villalta, Christians; Liu, Lu-Ping; Jiang, Xia; Huan-Huan, Qiao; Wang, Xia; Fujiyama, Asao; Toyoda, Atsushi; Ayers, Kathleen; Blum, Allison; Czech, Benjamin; Neumuller, Ralph; Yan, Dong; Cavallaro, Amanda; Hibbard, Karen; Hall, Don; Cooley, Lynn; Hannon, Gregory J.; Lehmann, Ruth; Parks, Annette; Mohr, Stephanie E.; Ueda, Ryu; Kondo, Shu; Ni, Jian-Quan; Perrimon, Norbert

2015-01-01

To facilitate large-scale functional studies in Drosophila, the Drosophila Transgenic RNAi Project (TRiP) at Harvard Medical School (HMS) was established along with several goals: developing efficient vectors for RNAi that work in all tissues, generating a genome-scale collection of RNAi stocks with input from the community, distributing the lines as they are generated through existing stock centers, validating as many lines as possible using RT–qPCR and phenotypic analyses, and developing tools and web resources for identifying RNAi lines and retrieving existing information on their quality. With these goals in mind, here we describe in detail the various tools we developed and the status of the collection, which is currently composed of 11,491 lines and covering 71% of Drosophila genes. Data on the characterization of the lines either by RT–qPCR or phenotype is available on a dedicated website, the RNAi Stock Validation and Phenotypes Project (RSVP, http://www.flyrnai.org/RSVP.html), and stocks are available from three stock centers, the Bloomington Drosophila Stock Center (United States), National Institute of Genetics (Japan), and TsingHua Fly Center (China). PMID:26320097

Developing methods of determining unknown roational periods of asteroids via observations of (3122) Florence by the Harvard Observing Project

Science.gov (United States)

Abrams, Natasha Sarah; Bieryla, Allyson; Gomez, Sebastian; Huang, Jane; Lewis, John; Todd, Zoe; Alam, Munazza; Carmichael, Theron; Garrison, Lehman H.; Weaver, Ian; Chen, Chen; McGruder, Chima; Medina, Amber

2018-06-01

(3122) Florence is an asteroid that made the headlines with its close approach to Earth in late 2017. It is one of the biggest and brightest near-Earth asteroids that has been discovered and it has recently been found to have two moons. By observing the light reflected off an asteroid, we can measure its brightness over time and determine the rotational period of the asteroid. An asteroid’s rotational period can reveal information about its physical characteristics, such as its shape, and further our knowledge about processes that contribute to asteroid rotation in general. The Harvard Observing Project (HOP) is an initiative that allows undergraduates to learn about observational astronomy and take part in formal data collection and analysis. Over the course of the fall 2017 semester, HOP obtained four multi-hour, continuous observations in the R-band of the asteroid using the Harvard University 16-inch Clay Telescope. In our analysis, we reduced the images and performed astrometry and photometry on the data. The asteroid’s light curve was produced using AstroImageJ and we used the Python package gatspy to determine its rotational period. We found the rotational period to be 2.22 hours +/- 0.25, which agrees with the known rotational period of 2.3580 hours +/- 0.0002. This spring 2018 semester we are applying our methods to data collected on asteroids with unknown rotational periods and plan to present our findings.

Foliar free polyamine and inorganic ion content in relation to soil and soil solution chemistry in two fertilized forest stands at the Harvard Forest, Massachusetts

Science.gov (United States)

Rakesh Minocha; Stephanie Long; Alison H. Magill; John Aber; William H. McDowell

2000-01-01

Polyamines (putrescine, spermidine, and spermine) are low molecular weight, open-chained, organic polycations which are found in all organisms and have been linked with stress responses in plants. The objectives of our study were to investigate the effects of chronic N additions to pine and hardwood stands at Harvard Forest, Petersham, MA on foliar polyamine and...

A model for training medical student innovators: the Harvard Medical School Center for Primary Care Abundance Agents of Change program.

Science.gov (United States)

Duong, David B; Sullivan, Erin E; Minter-Jordan, Myechia; Giesen, Lindsay; Ellner, Andrew L

2016-01-01

In 2013, the Harvard Medical School Center for Primary Care established the Abundance Agents of Change (AoC) program to promote interprofessional learning and innovation, increase partnership between 15 academic and community health centers (CHCs) in Boston's most under-served communities, and increase medical student interest in primary care careers. The AoC is modeled in the form of a 'grants challenge', offering $20,000 to interprofessional student teams to develop an innovative solution that addresses a healthcare delivery need identified by CHCs. The program's initial two years were characterized by a four-stage process which included working with CHCs and crafting a request for proposals, forming interprofessional 20 student teams comprising students from across and outside of Harvard University, training students using a systems-based innovation curriculum, and performing program evaluation. Our evaluation data from cohorts 1 and 2 of the AoC program demonstrate that we succeeded in training students as innovators and members of interprofessional teams. We also learned valuable lessons regarding creating better alignment with CHC priorities, extending the program cycle from 12 to 18 months, and changing the way funding is disbursed to 25 students, which will be incorporated in later versions of the program. Based on our experience and evaluation data, we believe that this program is a replicable way to train students as innovators and members of interprofessional teams to address the current complex healthcare environment.

New life for CERN's first accelerator

CERN Multimedia

Anaïs Schaeffer

2011-01-01

Building 300 right in the middle of the CERN site houses a special "antique": the Laboratory's very first accelerator. After several years in the wilderness following its decommissioning in 1990, the Synchrocyclotron is set to take on a new lease of life in the near future, this time as a visitor attraction.   The Synchrocyclotron as it was in 1975; it will be restored to this configuration for public viewing. The Synchrocyclotron (SC) began operation in 1957, two years before the PS was commissioned. Running at an energy of 600 MeV and producing beams of protons, neutrons, muons and pions, it helped to further research in the nuclear physics field for no fewer than 33 years, providing beams for various decay experiments as well as the muon capture experiment (*). Since the SC was decommissioned in 1990, three of its four buildings (160, 161 and 301) have been converted into offices for members of the ALICE collaboration, but the shielded hall housing the machine it...

A phase-I clinical trial for cranial BNCT at Harvard-MIT

International Nuclear Information System (INIS)

Busse, P.M.; Palmer, M.R.; Harling, O.K.

2000-01-01

Phase I trial designed to determine the maximum tolerable dose to normal tissue for cranial BNCT (Boron Neutron Capture Therapy) irradiations was recently completed at Harvard Medical School and MIT. Twenty-two subjects diagnosed with either glioblastoma multiforme or intracranial melanoma were treated between 1996 and 1999. Subjects received either one or two administrations of boronophenylalanine intravenously at doses between 250 and 350 mg/kg body weight, then exposed in one, two or three fields to epithermal neutrons at the MIT Research Reactor in one or two fractions. Over the course of the study, the maximum normal tissue dose target was increased from 8.8 to 14.2 RBE (Relative Biological Effectiveness) Gy in 10% increments. Subjects have been followed clinically and radiographically. Of those patients surviving beyond six months, no MRI (Magnetic Resonance Image) white-matter changes were observed and no long-term complications attributable to BNCT were evident. Tumor responses were observed, particularly with the melanoma subjects. With increasing doses, difficulties arose from long irradiation times (approximately 3 hours) and the emergence of acute reactions in the skin and mucosa. The trial was stopped in May 1999. Future trials will be initiated with the new high intensity, low background fission converter beam at MIT. (author)

Modification of Harvard step-test for assessment of students’ with health problems functional potentials

Directory of Open Access Journals (Sweden)

E.N. Kopeikina

2016-08-01

Full Text Available Purpose: to substantiate, work out and experimentally prove modified test for assessment of students’ with health problems functional potentials. Material: in the research students and girl students of 18-20 years’ age (n=522 participated. According to the worked out modification of test during 30 seconds student ascended on bench (h=43 cm and descended from it. Then pulse was measured three times. In total the test took 4 minutes. Results: For working out the scale for interpretation of the received results we assessed new 30 seconds’ modification of Harvard step-test for validity. First, for this purpose all students fulfilled modified step-test. Then after full restoration (after 20 minutes they fulfilled its three minutes’ variant. Correlation analysis of the received results showed the presence of average correlation between two samples (r=0.64. Conclusions: application of this modified variant permits for pedagogues to completely assess functional potentials of students with heath problems.

Adaptation of Harvard Trauma questionnaire for working with refugees and asylum seekers in Serbia

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Vukčević Maša

2016-01-01

Full Text Available The number of refugees and asylum seekers in Serbia is significantly increasing. Many have experienced traumatic events and suffer from posttraumatic stress disorder and depression. In order to provide them with adequate assistance, caregivers need adjusted assessment tools. The main goal of this research was the adaptation of the Harvard Trauma Questionnaire for working with refugees and asylum seekers in Serbia. A total of 16 focus groups were interviewed in two phases in order to create an adequate list of traumatic events for this population. The adapted list was subsequently administered to 226 persons seeking asylum in Serbia, along with the remaining parts of HTQ, HSCL-25 and BDI-II. Results show that the adapted list of traumatic events, as well as a shorter version, has good validity and other metric properties. The adaptation of the first assessment tool for working with refugees and asylum seekers in Serbia has significant practical implications.

Oligotyping reveals stronger relationship of organic soil bacterial community structure with N-amendments and soil chemistry in comparison to that of mineral soil at Harvard Forest, MA, USA

Science.gov (United States)

Swathi A. Turlapati; Rakesh Minocha; Stephanie Long; Jordan Ramsdell; Subhash C. Minocha

2015-01-01

The impact of chronic nitrogen amendments on bacterial communities was evaluated at Harvard Forest, Petersham, MA, USA. Thirty soil samples (3 treatments × 2 soil horizons × 5 subplots) were collected in 2009 from untreated (control), low nitrogen-amended (LN; 50 kg NH4NO3ha-1yr

Science at Harvard University: Historical Perspectives, edited by Clark A. Elliott and Margaret W. Rossiter. Lehigh University Press, Bethlehem, 1992

Directory of Open Access Journals (Sweden)

Andrew L. Christenson

1992-05-01

Full Text Available This volume contains historical studies of several sciences as practiced at Harvard University. Two of these studies have relevance to the history of archaeology. A chapter by Toby Appel focuses upon the scientific career of Jeffries Wyman, first curator of Harvard's Peabody Museum. She contrasts Wyman's unassuming character with the dominating personality of his mentor and contemporary Louis Agassiz. Trained as a medical doctor, Wyman's main love was zoology, particularly comparative anatomy. In his mid-40s, he encountered his first shell midden and was bitten by the archaeology bug. Soon he was doing pioneering excavation in both New England and Florida. In 1866, he was selected to be the curator of the Peabody Museum, primarily upon his strong museum background but also because of the high regard with which he was held by certain influential people. His selection to this position may have made him America's first professional archaeologist. His principal responsibilities were to collect and display archaeological and ethnological specimens and he made great steps in this direction prior to his death in 1874. Wyman's scientific work was poorly known or studied (he is best noted for having made the first scientific description of the gorilla, in part, Appel argues, because he did not seek acclaim or controversy. His greatest influence was locally through personal interactions with students and colleagues. His archaeological work is only briefly discussed in this and the following article, and there is still much to be written about this man of high character.

The SC gets ready for visitors

CERN Multimedia

Antonella Del Rosso

2012-01-01

Hall 300, which houses the Synchrocyclotron (SC), CERN’s first accelerator, is getting ready to host a brand-new exhibition. The site will be one of the stops on the new visit itineraries that will be inaugurated for the 2013 CERN Open Day.   The Synchrocyclotron through the years. Just as it did in the late 1950s, when the accelerator was first installed, the gigantic red structure of the Synchrocyclotron's magnet occupies a large part of the 300-square-metre hall. “We have completed the first phase of the project that will give the SC a new lease of life,” says Marco Silari, the project leader and a member of CERN’s Radiation Protection Group. “We have removed all the equipment that was not an integral part of the accelerator. The hall is now ready for the civil-engineering work that will precede the installation of the exhibition.” The SC was witness to a big part of the history of CERN. The accelerator produced ...

Specific trauma subtypes improve the predictive validity of the Harvard Trauma Questionnaire in Iraqi refugees.

Science.gov (United States)

Arnetz, Bengt B; Broadbridge, Carissa L; Jamil, Hikmet; Lumley, Mark A; Pole, Nnamdi; Barkho, Evone; Fakhouri, Monty; Talia, Yousif Rofa; Arnetz, Judith E

2014-12-01

Trauma exposure contributes to poor mental health among refugees, and exposure often is measured using a cumulative index of items from the Harvard Trauma Questionnaire (HTQ). Few studies, however, have asked whether trauma subtypes derived from the HTQ could be superior to this cumulative index in predicting mental health outcomes. A community sample of recently arrived Iraqi refugees (N = 298) completed the HTQ and measures of posttraumatic stress disorder (PTSD) and depression symptoms. Principal components analysis of HTQ items revealed a 5-component subtype model of trauma that accounted for more item variance than a 1-component solution. These trauma subtypes also accounted for more variance in PTSD and depression symptoms (12 and 10%, respectively) than did the cumulative trauma index (7 and 3%, respectively). Trauma subtypes provided more information than cumulative trauma in the prediction of negative mental health outcomes. Therefore, use of these subtypes may enhance the utility of the HTQ when assessing at-risk populations.

Specific Trauma Subtypes Improve the Predictive Validity of the Harvard Trauma Questionnaire in Iraqi Refugees

Science.gov (United States)

Arnetz, Bengt B.; Broadbridge, Carissa L.; Jamil, Hikmet; Lumley, Mark A.; Pole, Nnamdi; Barkho, Evone; Fakhouri, Monty; Talia, Yousif Rofa; Arnetz, Judith E.

2014-01-01

Background Trauma exposure contributes to poor mental health among refugees, and exposure often is measured using a cumulative index of items from the Harvard Trauma Questionnaire (HTQ). Few studies, however, have asked whether trauma subtypes derived from the HTQ could be superior to this cumulative index in predicting mental health outcomes. Methods A community sample of recently arrived Iraqi refugees (N = 298) completed the HTQ and measures of posttraumatic stress disorder (PTSD) and depression symptoms. Results Principal components analysis of HTQ items revealed a 5-component subtype model of trauma that accounted for more item variance than a 1-component solution. These trauma subtypes also accounted for more variance in PTSD and depression symptoms (12% and 10%, respectively) than did the cumulative trauma index (7% and 3%, respectively). Discussion Trauma subtypes provided more information than cumulative trauma in the prediction of negative mental health outcomes. Therefore, use of these subtypes may enhance the utility of the HTQ when assessing at-risk populations. PMID:24549491

Clinical treatment planning for subjects undergoing boron neutron capture therapy at Harvard-MIT

International Nuclear Information System (INIS)

Zamenhof, R.G.; Palmer, M.R.; Buse, P.M.

2001-01-01

Treatment planning is a crucial component of the Harvard-MIT boron neutron capture therapy (BNCT) clinical trials. Treatment planning can be divided into five stages: (1) pre-planning, based on CT and MRI scans obtained when the subject arrives at the hospital and on assumed boron-10 distribution parameters; (2) subject set-up, or simulation, in the MITR-II medical therapy room to determine the boundary conditions for possible set-up configurations; (3) re-planning, following the subject simulation; (4) final localization of the subject in the medical therapy room for BNCT; and (5) final post facto recalculation of the doses delivered based on firm knowledge of the blood boron-10 concentration profiles and the neutron flux histories from precise online monitoring. The computer-assisted treatment planning is done using a specially written BNCT treatment planning code called MacNCTPLAN. The code uses the Los Alamos National Laboratory's Monte Carlo n-particle radiation transport code MCNPv.4b as the dose calculation engine and advanced anatomical model simulation based on an automatic evaluation of CT scan data. Results are displayed as isodose contours and dose-volume histograms, the latter correlated precisely with corresponding anatomical CT or MRI image planes. Examples of typical treatment planning scenarios will be presented. (author)

Cyclotron Development and Technical Aspects on Accelerator Based Laboratory Development

International Nuclear Information System (INIS)

Sunarhadijoso

2000-01-01

BATAN is planning to establish an accelerator-based laboratory at P3TM Yogyakarta as an effort in the development and use of accelerator technology for improving industrial performance and public welfare. This paper reviews several aspects of cyclotron technology and describes the combination of a linear accelerator - cyclotron system as an alternative to be considered in the planing of the laboratory. The progress of cyclotron technology is discussed covering three generations, i.e. conventional cyclotron, synchrocyclotron and AVF cyclotron generations. The planning should not consider the accelerator application for radioisotope production because it is established in Serpong with the existing negative ion cyclotron. The proposed facility at P3TM may comprise two linear accelerators coupled with a positive ion cyclotron of synchrocyclotron generation. In fact, the attachment of the synchrocyclotron unit is flexible and it can be installed subsequently if the higher energy particle beam, which can not be produced by the linear accelerators, is extremely needed. Some technical aspects related to ion beam application, building construction and infrastructure, human resources, and specification of function test are discussed for additional information in the implementation of the planning. (author)

Pilot Point-of-Care Ultrasound Curriculum at Harvard Medical School: Early Experience

Science.gov (United States)

Rempell, Joshua S.; Saldana, Fidencio; DiSalvo, Donald; Kumar, Navin; Stone, Michael B.; Chan, Wilma; Luz, Jennifer; Noble, Vicki E.; Liteplo, Andrew; Kimberly, Heidi; Kohler, Minna J.

2016-01-01

Introduction Point-of-care ultrasound (POCUS) is expanding across all medical specialties. As the benefits of US technology are becoming apparent, efforts to integrate US into pre-clinical medical education are growing. Our objective was to describe our process of integrating POCUS as an educational tool into the medical school curriculum and how such efforts are perceived by students. Methods This was a pilot study to introduce ultrasonography into the Harvard Medical School curriculum to first- and second-year medical students. Didactic and hands-on sessions were introduced to first-year students during gross anatomy and to second-year students in the physical exam course. Student-perceived attitudes, understanding, and knowledge of US, and its applications to learning the physical exam, were measured by a post-assessment survey. Results All first-year anatomy students (n=176) participated in small group hands-on US sessions. In the second-year physical diagnosis course, 38 students participated in four sessions. All students (91%) agreed or strongly agreed that additional US teaching should be incorporated throughout the four-year medical school curriculum. Conclusion POCUS can effectively be integrated into the existing medical school curriculum by using didactic and small group hands-on sessions. Medical students perceived US training as valuable in understanding human anatomy and in learning physical exam skills. This innovative program demonstrates US as an additional learning modality. Future goals include expanding on this work to incorporate US education into all four years of medical school. PMID:27833681

Geologic map of the Harvard Lakes 7.5' quadrangle, Park and Chaffee Counties, Colorado

Science.gov (United States)

Kellogg, Karl S.; Lee, Keenan; Premo, Wayne R.; Cosca, Michael A.

2013-01-01

The Harvard Lakes 1:24,000-scale quadrangle spans the Arkansas River Valley in central Colorado, and includes the foothills of the Sawatch Range on the west and Mosquito Range on the east. The Arkansas River valley lies in the northern end of the Rio Grande rift and is structurally controlled by Oligocene and younger normal faults mostly along the west side of the valley. Five separate pediment surfaces were mapped, and distinctions were made between terraces formed by the Arkansas River and surfaces that formed from erosion and alluviation that emanated from the Sawatch Range. Three flood deposits containing boulders as long as 15 m were deposited from glacial breakouts just north of the quadrangle. Miocene and Pliocene basin-fill deposits of the Dry Union Formation are exposed beneath terrace or pediment deposits in several places. The southwestern part of the late Eocene Buffalo Peaks volcanic center, mostly andesitic breccias and flows and ash-flow tuffs, occupy the northeastern corner of the map. Dated Tertiary intrusive rocks include Late Cretaceous or early Paleocene hornblende gabbro and hornblende monzonite. Numerous rhyolite and dacite dikes of inferred early Tertiary or Late Cretaceous age also intrude the basement rocks. Basement rocks are predominantly Mesoproterozoic granites, and subordinately Paleoproterozoic biotite gneiss and granitic gneiss.

[Variations in the epidemiolgy of adverse events: methodology of the Harvard Medical Practice Design].

Science.gov (United States)

Lessing, C; Schmitz, A; Schrappe, M

2012-02-01

The Harvard Medical Practice (HMP) Design is based on a multi-staged retrospective review of inpatient records and is used to assess the frequency of (preventable) adverse events ([P]AE) in large study populations. Up to now HMP studies have been conducted in 9 countries. Results differ largely from 2.9% to 3.7% of patients with AE in the USA up to 16.6% in Australia. In our analysis we systematically compare the methodology of 9 HMP studies published in the English language and discuss possible impacts on reported frequencies. Modifications in HMP studies can be individualised from each stage of planning, conducting, and reporting results. In doing so 2 studies from the USA with lowest rates of AE can be characterised by their context of liability and the absence of screening for nosocomial infections. Studies with a high proportion of AE are marked by an intense training of reviewers. Further conclusions are hindered by divergences in defining periods of observation, by presenting frequencies as cumulative prevalences, and differences in the reporting of study results. As a consequence future HMP studies should go for complete, consistent and transparent coverage. Further research should concentrate on advancing methods for collecting data on (P)AE. © Georg Thieme Verlag KG Stuttgart · New York.

Rethinking the Response to Emerging Microbes: Vaccines and Therapeutics in the Ebola Era--a Conference at Harvard Medical School.

Science.gov (United States)

Knipe, David M; Whelan, Sean P

2015-08-01

Harvard Medical School convened a meeting of biomedical and clinical experts on 5 March 2015 on the topic of "Rethinking the Response to Emerging Microbes: Vaccines and Therapeutics in the Ebola Era," with the goals of discussing the lessons from the recent Ebola outbreak and using those lessons as a case study to aid preparations for future emerging infections. The speakers and audience discussed the special challenges in combatting an infectious agent that causes sporadic outbreaks in resource-poor countries. The meeting led to a call for improved basic medical care for all and continued support of basic discovery research to provide the foundation for preparedness for future outbreaks in addition to the targeted emergency response to outbreaks and targeted research programs against Ebola virus and other specific emerging pathogens. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Policies to increase the social value of science and the scientist satisfaction. An exploratory survey among Harvard bioscientists.

Science.gov (United States)

Ballabeni, Andrea; Boggio, Andrea; Hemenway, David

2014-01-01

Basic research in the biomedical field generates both knowledge that has a value per se regardless of its possible practical outcome and knowledge that has the potential to produce more practical benefits. Policies can increase the benefit potential to society of basic biomedical research by offering various kinds of incentives to basic researchers. In this paper we argue that soft incentives or "nudges" are particularly promising. However, to be well designed, these incentives must take into account the motivations, goals and views of the basic scientists. In the paper we present the results of an investigation that involved more than 300 scientists at Harvard Medical School and affiliated institutes. The results of this study suggest that some soft incentives could be valuable tools to increase the transformative value of fundamental investigations without affecting the spirit of the basic research and scientists' work satisfaction. After discussing the findings, we discuss a few examples of nudges for basic researchers in the biomedical fields.

Validation of a French adaptation of the Harvard Trauma Questionnaire among torture survivors from sub-Saharan African countries

Science.gov (United States)

de Fouchier, Capucine; Blanchet, Alain; Hopkins, William; Bui, Eric; Ait-Aoudia, Malik; Jehel, Louis

2012-01-01

Background To date no validated instrument in the French language exists to screen for posttraumatic stress disorder (PTSD) in survivors of torture and organized violence. Objective The aim of this study is to adapt and validate the Harvard Trauma Questionnaire (HTQ) to this population. Method The adapted version was administered to 52 French-speaking torture survivors, originally from sub-Saharan African countries, receiving psychological treatment in specialized treatment centers. A structured clinical interview for DSM was also conducted in order to assess if they met criteria for PTSD. Results Cronbach's alpha coefficient for the HTQ Part 4 was adequate (0.95). Criterion validity was evaluated using receiver operating characteristic curve analysis that generated good classification accuracy for PTSD (0.83). At the original cut-off score of 2.5, the HTQ demonstrated high sensitivity and specificity (0.87 and 0.73, respectively). Conclusion Results support the reliability and validity of the French version of the HTQ. PMID:23233870

Policies to increase the social value of science and the scientist satisfaction. An exploratory survey among Harvard bioscientists.

Science.gov (United States)

Ballabeni, Andrea; Boggio, Andrea; Hemenway, David

2014-01-01

Basic research in the biomedical field generates both knowledge that has a value per se regardless of its possible practical outcome and knowledge that has the potential to produce more practical benefits. Policies can increase the benefit potential to society of basic biomedical research by offering various kinds of incentives to basic researchers. In this paper we argue that soft incentives or “nudges” are particularly promising. However, to be well designed, these incentives must take into account the motivations, goals and views of the basic scientists. In the paper we present the results of an investigation that involved more than 300 scientists at Harvard Medical School and affiliated institutes. The results of this study suggest that some soft incentives could be valuable tools to increase the transformative value of fundamental investigations without affecting the spirit of the basic research and scientists’ work satisfaction. After discussing the findings, we discuss a few examples of nudges for basic researchers in the biomedical fields. PMID:24795807

Validation of a French adaptation of the Harvard Trauma Questionnaire among torture survivors from sub-Saharan African countries

Directory of Open Access Journals (Sweden)

Capucine de Fouchier

2012-12-01

Full Text Available Background: To date no validated instrument in the French language exists to screen for posttraumatic stress disorder (PTSD in survivors of torture and organized violence. Objective: The aim of this study is to adapt and validate the Harvard Trauma Questionnaire (HTQ to this population. Method: The adapted version was administered to 52 French-speaking torture survivors, originally from sub-Saharan African countries, receiving psychological treatment in specialized treatment centers. A structured clinical interview for DSM was also conducted in order to assess if they met criteria for PTSD. Results: Cronbach's alpha coefficient for the HTQ Part 4 was adequate (0.95. Criterion validity was evaluated using receiver operating characteristic curve analysis that generated good classification accuracy for PTSD (0.83. At the original cut-off score of 2.5, the HTQ demonstrated high sensitivity and specificity (0.87 and 0.73, respectively. Conclusion: Results support the reliability and validity of the French version of the HTQ.

Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study.

Science.gov (United States)

Ding, Hongliu; Dhima, Kaltra; Lockhart, Kaitlin C; Locascio, Joseph J; Hoesing, Ashley N; Duong, Karen; Trisini-Lipsanopoulos, Ana; Hayes, Michael T; Sohur, U Shivraj; Wills, Anne-Marie; Mollenhauer, Brit; Flaherty, Alice W; Hung, Albert Y; Mejia, Nicte; Khurana, Vikram; Gomperts, Stephen N; Selkoe, Dennis J; Schwarzschild, Michael A; Schlossmacher, Michael G; Hyman, Bradley T; Sudarsky, Lewis R; Growdon, John H; Scherzer, Clemens R

2013-10-22

To conclusively test for a specific association between the biological marker 25-hydroxy-vitamin D3, a transcriptionally active hormone produced in human skin and liver, and the prevalence and severity of Parkinson disease (PD). We used liquid chromatography/tandem mass spectrometry to establish an association specifically between deficiency of 25-hydroxy-vitamin D3 and PD in a cross-sectional and longitudinal case-control study of 388 patients (mean Hoehn and Yahr stage of 2.1 ± 0.6) and 283 control subjects free of neurologic disease nested in the Harvard Biomarker Study. Plasma levels of 25-hydroxy-vitamin D3 were associated with PD in both univariate and multivariate analyses with p values = 0.0034 and 0.047, respectively. Total 25-hydroxy-vitamin D levels, the traditional composite measure of endogenous and exogenous vitamin D, were deficient in 17.6% of patients with PD compared with 9.3% of controls. Low 25-hydroxy-vitamin D3 as well as total 25-hydroxy-vitamin D levels were correlated with higher total Unified Parkinson's Disease Rating Scale scores at baseline and during follow-up. Our study reveals an association between 25-hydroxy-vitamin D3 and PD and suggests that thousands of patients with PD in North America alone may be vitamin D-deficient. This finding has immediate relevance for individual patients at risk of falls as well as public health, and warrants further investigation into the mechanism underlying this association.

The psychopharmacology algorithm project at the Harvard South Shore Program: an update on schizophrenia.

Science.gov (United States)

Osser, David N; Roudsari, Mohsen Jalali; Manschreck, Theo

2013-01-01

This article is an update of the algorithm for schizophrenia from the Psychopharmacology Algorithm Project at the Harvard South Shore Program. A literature review was conducted focusing on new data since the last published version (1999-2001). The first-line treatment recommendation for new-onset schizophrenia is with amisulpride, aripiprazole, risperidone, or ziprasidone for four to six weeks. In some settings the trial could be shorter, considering that evidence of clear improvement with antipsychotics usually occurs within the first two weeks. If the trial of the first antipsychotic cannot be completed due to intolerance, try another until one of the four is tolerated and given an adequate trial. There should be evidence of bioavailability. If the response to this adequate trial is unsatisfactory, try a second monotherapy. If the response to this second adequate trial is also unsatisfactory, and if at least one of the first two trials was with risperidone, olanzapine, or a first-generation (typical) antipsychotic, then clozapine is recommended for the third trial. If neither trial was with any these three options, a third trial prior to clozapine should occur, using one of those three. If the response to monotherapy with clozapine (with dose adjusted by using plasma levels) is unsatisfactory, consider adding risperidone, lamotrigine, or ECT. Beyond that point, there is little solid evidence to support further psychopharmacological treatment choices, though we do review possible options.

Proton beam dosimetry for radiosurgery: implementation of the ICRU Report 59 at the Harvard Cyclotron Laboratory

International Nuclear Information System (INIS)

Newhauser, Wayne D.; Myers, Karla D.; Rosenthal, Stanley J.; Smith, Alfred R.

2002-01-01

Recent proton dosimetry intercomparisons have demonstrated that the adoption of a common protocol, e.g. ICRU Report 59, can lead to improved consistency in absorbed dose determinations. We compared absorbed dose values, measured in the 160 MeV proton radiosurgery beamline at the Harvard Cyclotron Laboratory, based on ionization chamber methods with those from a Faraday cup technique. The Faraday cup method is based on a proton fluence determination that allows the estimation of absorbed dose with the CEMA approximation, under which the dose is equal to the fluence times the mean mass stopping power. The ionization chamber technique employs an air-kerma calibration coefficient for 60 Co radiation and a calculated correction in order to take into account the differences in response to 60 Co and proton beam radiations. The absorbed dose to water, based on a diode measurement calibrated with a Faraday cup technique, is approximately 2% higher than was obtained from an ionization chamber measurement. At the Bragg peak depth, the techniques agree to within their respective uncertainties, which are both approximately 4% (1 standard deviation). The ionization chamber technique exhibited superior reproducibility and was adopted in our standard clinical practice for radiosurgery. (author)

The Harvard Medical School Academic Innovations Collaborative: transforming primary care practice and education.

Science.gov (United States)

Bitton, Asaf; Ellner, Andrew; Pabo, Erika; Stout, Somava; Sugarman, Jonathan R; Sevin, Cory; Goodell, Kristen; Bassett, Jill S; Phillips, Russell S

2014-09-01

Academic medical centers (AMCs) need new approaches to delivering higher-quality care at lower costs, and engaging trainees in the work of high-functioning primary care practices. In 2012, the Harvard Medical School Center for Primary Care, in partnership with with local AMCs, established an Academic Innovations Collaborative (AIC) with the goal of transforming primary care education and practice. This novel two-year learning collaborative consisted of hospital- and community-based primary care teaching practices, committed to building highly functional teams, managing populations, and engaging patients. The AIC built on models developed by Qualis Health and the Institute for Healthcare Improvement, optimized for the local AMC context. Foundational elements included leadership engagement and development, application of rapid-cycle process improvement, and the creation of teams to care for defined patient populations. Nineteen practices across six AMCs participated, with nearly 260,000 patients and 450 resident learners. The collaborative offered three 1.5-day learning sessions each year featuring shared learning, practice coaches, and improvement measures, along with monthly data reporting, webinars, and site visits. Validated self-reports by transformation teams showed that practices made substantial improvement across all areas of change. Important factors for success included leadership development, practice-level resources, and engaging patients and trainees. The AIC model shows promise as a path for AMCs to catalyze health system transformation through primary care improvement. In addition to further evaluating the impact of practice transformation, expansion will require support from AMCs and payers, and the application of similar approaches on a broader scale.

The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An Algorithm for Generalized Anxiety Disorder.

Science.gov (United States)

Abejuela, Harmony Raylen; Osser, David N

2016-01-01

This revision of previous algorithms for the pharmacotherapy of generalized anxiety disorder was developed by the Psychopharmacology Algorithm Project at the Harvard South Shore Program. Algorithms from 1999 and 2010 and associated references were reevaluated. Newer studies and reviews published from 2008-14 were obtained from PubMed and analyzed with a focus on their potential to justify changes in the recommendations. Exceptions to the main algorithm for special patient populations, such as women of childbearing potential, pregnant women, the elderly, and those with common medical and psychiatric comorbidities, were considered. Selective serotonin reuptake inhibitors (SSRIs) are still the basic first-line medication. Early alternatives include duloxetine, buspirone, hydroxyzine, pregabalin, or bupropion, in that order. If response is inadequate, then the second recommendation is to try a different SSRI. Additional alternatives now include benzodiazepines, venlafaxine, kava, and agomelatine. If the response to the second SSRI is unsatisfactory, then the recommendation is to try a serotonin-norepinephrine reuptake inhibitor (SNRI). Other alternatives to SSRIs and SNRIs for treatment-resistant or treatment-intolerant patients include tricyclic antidepressants, second-generation antipsychotics, and valproate. This revision of the GAD algorithm responds to issues raised by new treatments under development (such as pregabalin) and organizes the evidence systematically for practical clinical application.

Assessment of orientation practices for ethics consultation at Harvard Medical School-affiliated hospitals.

Science.gov (United States)

Zaidi, Danish; Kesselheim, Jennifer C

2018-02-01

Few studies have been conducted to assess the quality of orientation practices for ethics advisory committees that conduct ethics consultation. This survey study focused on several Harvard teaching hospitals, exploring orientation quality and committee members' self-evaluation in the American Society of Bioethics and Humanities (ASBH) ethics consultation competencies. We conducted a survey study that involved 116 members and 16 chairs of ethics advisory committees, respectively (52% and 62.5% response rates). Predictor variables included professional demographics, duration on committees and level of training. Outcome variables included familiarity with and preparedness in the ASBH competencies and satisfaction with orientations. We hypothesised that responses would be associated with both the aforementioned predictors and whether or not participants had encountered the ASBH competencies in training. A majority of respondents found their orientation curricula to be helpful (62%), although a significant portion of respondents did not receive any orientation (24%) or were unsatisfied with their orientation (14%). Familiarity with ASBH competencies was a statistically significant predictor of respondents' self-evaluation in particular categories (54% had heard of the competencies). Standard educational materials were reported as offered during orientation, such as readings (50%) and case studies (41%); different medium resources were less evidenced such as videos on ethics consultation (19%). Institutions should re-evaluate orientation practices for ethics committee members that perform ethics consultation. Integrating ASBH competencies and useful methods into a resourceful pedagogy will help improve both member satisfaction with orientation and preparation in consultation. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Progress report, 1978

International Nuclear Information System (INIS)

During the calendar year 1978 upgrading of the synchrocyclotron was completed and proton, deuteron and alpha beams were extensively used. Research continued into far-unstable nuclei, complex nuclear reaction and nuclear fission mechanisms, and positron tomography. (LL)

Accelerator Division annual report, January 1976--September 1977

International Nuclear Information System (INIS)

1977-01-01

Accelerator operations of the Bevatron/Bevalac, the SuperHILAC, and the 184-Inch Synchrocyclotron are described. The PEP storage ring is described. The superconducting accelerator (ESCAR) construction is reported, and experiments in heavy ion fusion are described

The potential to characterize ecological data with terrestrial laser scanning in Harvard Forest, MA

Science.gov (United States)

Boucher, P.; Saenz, E.; Li, Z.

2018-01-01

Contemporary terrestrial laser scanning (TLS) is being used widely in forest ecology applications to examine ecosystem properties at increasing spatial and temporal scales. Harvard Forest (HF) in Petersham, MA, USA, is a long-term ecological research (LTER) site, a National Ecological Observatory Network (NEON) location and contains a 35 ha plot which is part of Smithsonian Institution's Forest Global Earth Observatory (ForestGEO). The combination of long-term field plots, eddy flux towers and the detailed past historical records has made HF very appealing for a variety of remote sensing studies. Terrestrial laser scanners, including three pioneering research instruments: the Echidna Validation Instrument, the Dual-Wavelength Echidna Lidar and the Compact Biomass Lidar, have already been used both independently and in conjunction with airborne laser scanning data and forest census data to characterize forest dynamics. TLS approaches include three-dimensional reconstructions of a plot over time, establishing the impact of ice storm damage on forest canopy structure, and characterizing eastern hemlock (Tsuga canadensis) canopy health affected by an invasive insect, the hemlock woolly adelgid (Adelges tsugae). Efforts such as those deployed at HF are demonstrating the power of TLS as a tool for monitoring ecological dynamics, identifying emerging forest health issues, measuring forest biomass and capturing ecological data relevant to other disciplines. This paper highlights various aspects of the ForestGEO plot that are important to current TLS work, the potential for exchange between forest ecology and TLS, and emphasizes the strength of combining TLS data with long-term ecological field data to create emerging opportunities for scientific study. PMID:29503723

The potential to characterize ecological data with terrestrial laser scanning in Harvard Forest, MA.

Science.gov (United States)

Orwig, D A; Boucher, P; Paynter, I; Saenz, E; Li, Z; Schaaf, C

2018-04-06

Contemporary terrestrial laser scanning (TLS) is being used widely in forest ecology applications to examine ecosystem properties at increasing spatial and temporal scales. Harvard Forest (HF) in Petersham, MA, USA, is a long-term ecological research (LTER) site, a National Ecological Observatory Network (NEON) location and contains a 35 ha plot which is part of Smithsonian Institution's Forest Global Earth Observatory (ForestGEO). The combination of long-term field plots, eddy flux towers and the detailed past historical records has made HF very appealing for a variety of remote sensing studies. Terrestrial laser scanners, including three pioneering research instruments: the Echidna Validation Instrument, the Dual-Wavelength Echidna Lidar and the Compact Biomass Lidar, have already been used both independently and in conjunction with airborne laser scanning data and forest census data to characterize forest dynamics. TLS approaches include three-dimensional reconstructions of a plot over time, establishing the impact of ice storm damage on forest canopy structure, and characterizing eastern hemlock ( Tsuga canadensis ) canopy health affected by an invasive insect, the hemlock woolly adelgid ( Adelges tsugae ). Efforts such as those deployed at HF are demonstrating the power of TLS as a tool for monitoring ecological dynamics, identifying emerging forest health issues, measuring forest biomass and capturing ecological data relevant to other disciplines. This paper highlights various aspects of the ForestGEO plot that are important to current TLS work, the potential for exchange between forest ecology and TLS, and emphasizes the strength of combining TLS data with long-term ecological field data to create emerging opportunities for scientific study.

Experiments at CERN in 1981

International Nuclear Information System (INIS)

1981-08-01

This report contains the preliminary abstracts of the current experiments at the CERN SPS synchrotron, the anti p colliding beams, the CERN ISR, the CERN PS synchrotron, and the CERN synchrocyclotron. See hints under the relevant topics. (HSI)

Evaluation of environmental filtration control of engineered nanoparticles using the Harvard Versatile Engineered Nanomaterial Generation System (VENGES)

Science.gov (United States)

Echevarría-Vega, Manuel E.; Sotiriou, Georgios A.; Santeufemio, Christopher; Schmidt, Daniel; Demokritou, Philip; Ellenbecker, Michael

2013-01-01

Applying engineering controls to airborne engineered nanoparticles (ENPs) is critical to prevent environmental releases and worker exposure. This study evaluated the effectiveness of two air sampling and six air cleaning fabric filters at collecting ENPs using industrially relevant flame-made engineered nanoparticles generated using a versatile engineered nanomaterial generation system (VENGES), recently designed and constructed at Harvard University. VENGES has the ability to generate metal and metal oxide exposure atmospheres while controlling important particle properties such as primary particle size, aerosol size distribution, and agglomeration state. For this study, amorphous SiO2 ENPs with a 15.4 nm primary particle size were generated and diluted with HEPA-filtered air. The aerosol was passed through the filter samples at two different filtration face velocities (2.3 and 3.5 m/min). Particle concentrations as a function of particle size were measured upstream and downstream of the filters using a specially designed filter test system to evaluate filtration efficiency. Real time instruments (FMPS and APS) were used to measure particle concentration for diameters from 5 to 20,000 nm. Membrane-coated fabric filters were found to have enhanced nanoparticle collection efficiency by 20–46 % points compared to non-coated fabric and could provide collection efficiency above 95 %. PMID:23412707

Dosimetry for ocular proton beam therapy at the Harvard Cyclotron Laboratory based on the ICRU Report 59

International Nuclear Information System (INIS)

Newhauser, W.D.; Burns, J.; Smith, A.R.

2002-01-01

The Massachusetts General Hospital, the Harvard Cyclotron Laboratory (HCL), and the Massachusetts Eye and Ear Infirmary have treated almost 3000 patients with ocular disease using high-energy external-beam proton radiation therapy since 1975. The absorbed dose standard for ocular proton therapy beams at HCL was based on a fluence measurement with a Faraday cup (FC). A majority of proton therapy centers worldwide, however, use an absorbed dose standard that is based on an ionization chamber (IC) technique. The ion chamber calibration is deduced from a measurement in a reference 60 Co photon field together with a calculated correction factor that takes into account differences in a chamber's response in 60 Co and proton fields. In this work, we implemented an ionization chamber-based absolute dosimetry system for the HCL ocular beamline based on the recommendations given in Report 59 by the International Commission on Radiation Units and Measurements. Comparative measurements revealed that the FC system yields an absorbed dose to water value that is 1.1% higher than was obtained with the IC system. That difference is small compared with the experimental uncertainties and is clinically insignificant. In June of 1998, we adopted the IC-based method as our standard practice for the ocular beam

Evaluation of environmental filtration control of engineered nanoparticles using the Harvard Versatile Engineered Nanomaterial Generation System (VENGES)

International Nuclear Information System (INIS)

Tsai, Candace S.-J.; Echevarría-Vega, Manuel E.; Sotiriou, Georgios A.; Santeufemio, Christopher; Schmidt, Daniel; Demokritou, Philip; Ellenbecker, Michael

2012-01-01

Applying engineering controls to airborne engineered nanoparticles (ENPs) is critical to prevent environmental releases and worker exposure. This study evaluated the effectiveness of two air sampling and six air cleaning fabric filters at collecting ENPs using industrially relevant flame-made engineered nanoparticles generated using a versatile engineered nanomaterial generation system (VENGES), recently designed and constructed at Harvard University. VENGES has the ability to generate metal and metal oxide exposure atmospheres while controlling important particle properties such as primary particle size, aerosol size distribution, and agglomeration state. For this study, amorphous SiO 2 ENPs with a 15.4 nm primary particle size were generated and diluted with HEPA-filtered air. The aerosol was passed through the filter samples at two different filtration face velocities (2.3 and 3.5 m/min). Particle concentrations as a function of particle size were measured upstream and downstream of the filters using a specially designed filter test system to evaluate filtration efficiency. Real time instruments (FMPS and APS) were used to measure particle concentration for diameters from 5 to 20,000 nm. Membrane-coated fabric filters were found to have enhanced nanoparticle collection efficiency by 20–46 % points compared to non-coated fabric and could provide collection efficiency above 95%.

Evidence for stagnation of the Harvard sublobe (Lake Michigan lobe) in Northeastern Illinois, U.S.A., from 24 000 to 17 600 BP and subsequent tundra-like ice-marginal paleoenvironments from 17 600 to 15 700 BP

Science.gov (United States)

Curry, B. Brandon; Yansa, C.H.

2004-01-01

Glacial deposits of the last glaciation associated with the Harvard sublobe (Lake Michigan lobe) in northeastern Illinois, U.S.A., occur between sediment with dateable organics. The lower organics include fragments of Picea sp. as young as 24 000 ?? 270 BP. The supraglacial organics occur sparsely in laminated silt and fine sand in landforms that are positioned relatively high on the landscape, such as deposits from ice-walled lakes. These terrestrial organics yield ages that are 2500 to 1300 14C years older than organics at the base of sediment successions in nearby kettle basins. Basal 14C ages from four upland sites range from 17 610 ?? 270 to 16 120 ?? 80 BP. Our revised time-distance diagram of the Harvard sublobe now reflects a period of stagnation from 24 000 to about 17 600 BP. The supraglacial lacustrine silt yielded plant macrofossil assemblages of primarily tundra plants, including Salix herbacea and Dryas integrifolia. These plants likely grew in supraglacial and ice-marginal environments. The ostracode fauna include Cytherissa lacustris and Limnocythere friabilis. Geomorphic relations and ostracode ecology indicate that more than 17 m of ice buttressed some of the supraglacial lakes.

Of mice and men

CERN Multimedia

1973-01-01

At the end of March , sixty mice were irradiated at the synchro-cyclotron in the course of an experimental programme studying radiation effects on mice and plants (Vicia faba bean roots) being carried out by the CERN Health Physics Group.

Accelerator operations

International Nuclear Information System (INIS)

Anon.

1979-01-01

Operations of the SuperHILAC, the Bevatron/Bevalac, and the 184-inch Synchrocyclotron during the period from October 1977 to September 1978 are discussed. These include ion source development, accelerator facilities, the Heavy Ion Spectrometer System, and Bevelac biomedical operations

Building laboratory capacity to support HIV care in Nigeria: Harvard/APIN PEPFAR, 2004-2012.

Science.gov (United States)

Hamel, Donald J; Sankalé, Jean-Louis; Samuels, Jay Osi; Sarr, Abdoulaye D; Chaplin, Beth; Ofuche, Eke; Meloni, Seema T; Okonkwo, Prosper; Kanki, Phyllis J

From 2004-2012, the Harvard/AIDS Prevention Initiative in Nigeria, funded through the US President's Emergency Plan for AIDS Relief programme, scaled up HIV care and treatment services in Nigeria. We describe the methodologies and collaborative processes developed to improve laboratory capacity significantly in a resource-limited setting. These methods were implemented at 35 clinic and laboratory locations. Systems were established and modified to optimise numerous laboratory processes. These included strategies for clinic selection and management, equipment and reagent procurement, supply chains, laboratory renovations, equipment maintenance, electronic data management, quality development programmes and trainings. Over the eight-year programme, laboratories supported 160 000 patients receiving HIV care in Nigeria, delivering over 2.5 million test results, including regular viral load quantitation. External quality assurance systems were established for CD4+ cell count enumeration, blood chemistries and viral load monitoring. Laboratory equipment platforms were improved and standardised and use of point-of-care analysers was expanded. Laboratory training workshops supported laboratories toward increasing staff skills and improving overall quality. Participation in a World Health Organisation-led African laboratory quality improvement system resulted in significant gains in quality measures at five laboratories. Targeted implementation of laboratory development processes, during simultaneous scale-up of HIV treatment programmes in a resource-limited setting, can elicit meaningful gains in laboratory quality and capacity. Systems to improve the physical laboratory environment, develop laboratory staff, create improvements to reduce costs and increase quality are available for future health and laboratory strengthening programmes. We hope that the strategies employed may inform and encourage the development of other laboratories in resource-limited settings.

arXiv Cyclotrons: Magnetic Design and Beam Dynamics

CERN Document Server

Zaremba, Simon

Classical, isochronous, and synchro-cyclotrons are introduced. Transverse and longitudinal beam dynamics in these accelerators are covered. The problem of vertical focusing and iscochronism in compact isochronous cyclotrons is treated in some detail. Different methods for isochronization of the cyclotron magnetic field are discussed. The limits of the classical cyclotron are explained. Typical features of the synchro-cyclotron, such as the beam capture problem, stable phase motion, and the extraction problem are discussed. The main design goals for beam injection are explained and special problems related to a central region with an internal ion source are considered. The principle of a Penning ion gauge source is addressed. The issue of vertical focusing in the cyclotron centre is briefly discussed. Several examples of numerical simulations are given. Different methods of (axial) injection are briefly outlined. Different solutions for beam extraction are described. These include the internal target, extracti...

The Harvard Beat Assessment Test (H-BAT): a battery for assessing beat perception and production and their dissociation

Science.gov (United States)

Fujii, Shinya; Schlaug, Gottfried

2013-01-01

Humans have the abilities to perceive, produce, and synchronize with a musical beat, yet there are widespread individual differences. To investigate these abilities and to determine if a dissociation between beat perception and production exists, we developed the Harvard Beat Assessment Test (H-BAT), a new battery that assesses beat perception and production abilities. H-BAT consists of four subtests: (1) music tapping test (MTT), (2) beat saliency test (BST), (3) beat interval test (BIT), and (4) beat finding and interval test (BFIT). MTT measures the degree of tapping synchronization with the beat of music, whereas BST, BIT, and BFIT measure perception and production thresholds via psychophysical adaptive stair-case methods. We administered the H-BAT on thirty individuals and investigated the performance distribution across these individuals in each subtest. There was a wide distribution in individual abilities to tap in synchrony with the beat of music during the MTT. The degree of synchronization consistency was negatively correlated with thresholds in the BST, BIT, and BFIT: a lower degree of synchronization was associated with higher perception and production thresholds. H-BAT can be a useful tool in determining an individual's ability to perceive and produce a beat within a single session. PMID:24324421

The Harvard Beat Assessment Test (H-BAT): a battery for assessing beat perception and production and their dissociation.

Science.gov (United States)

Fujii, Shinya; Schlaug, Gottfried

2013-01-01

Humans have the abilities to perceive, produce, and synchronize with a musical beat, yet there are widespread individual differences. To investigate these abilities and to determine if a dissociation between beat perception and production exists, we developed the Harvard Beat Assessment Test (H-BAT), a new battery that assesses beat perception and production abilities. H-BAT consists of four subtests: (1) music tapping test (MTT), (2) beat saliency test (BST), (3) beat interval test (BIT), and (4) beat finding and interval test (BFIT). MTT measures the degree of tapping synchronization with the beat of music, whereas BST, BIT, and BFIT measure perception and production thresholds via psychophysical adaptive stair-case methods. We administered the H-BAT on thirty individuals and investigated the performance distribution across these individuals in each subtest. There was a wide distribution in individual abilities to tap in synchrony with the beat of music during the MTT. The degree of synchronization consistency was negatively correlated with thresholds in the BST, BIT, and BFIT: a lower degree of synchronization was associated with higher perception and production thresholds. H-BAT can be a useful tool in determining an individual's ability to perceive and produce a beat within a single session.

Posttraumatic stress disorder among refugees: Measurement invariance of Harvard Trauma Questionnaire scores across global regions and response patterns.

Science.gov (United States)

Rasmussen, Andrew; Verkuilen, Jay; Ho, Emily; Fan, Yuyu

2015-12-01

Despite the central role of posttraumatic stress disorder (PTSD) in international humanitarian aid work, there has been little examination of the measurement invariance of PTSD measures across culturally defined refugee subgroups. This leaves mental health workers in disaster settings with little to support inferences made using the results of standard clinical assessment tools, such as the severity of symptoms and prevalence rates. We examined measurement invariance in scores from the most widely used PTSD measure in refugee populations, the Harvard Trauma Questionnaire (HTQ; Mollica et al., 1992), in a multinational and multilingual sample of asylum seekers from 81 countries of origin in 11 global regions. Clustering HTQ responses to justify grouping regional groups by response patterns resulted in 3 groups for testing measurement invariance: West Africans, Himalayans, and all others. Comparing log-likelihood ratios showed that while configural invariance seemed to hold, metric and scalar invariance did not. These findings call into question the common practice of using standard cut-off scores on PTSD measures across culturally dissimilar refugee populations. In addition, high correlation between factors suggests that the construct validity of scores from North American and European measures of PTSD may not hold globally. (c) 2015 APA, all rights reserved).

CERN: SC-33

Energy Technology Data Exchange (ETDEWEB)

Anon.

1991-06-15

On 22 April a forward-looking CERN also looked back for a day, when the 'SC-33' event reviewed the achievements of CERN's first machine, the 600 MeV SynchroCyclotron (SC), which closed down on 17 December after 33 years of valiant service.

Spectrometer based on the silicon semiconductor detectors for a study of the two charged particles correlation

International Nuclear Information System (INIS)

Krumsztein, Z.W.; Siemiarczuk, T.; Szawlowski, M.

1974-01-01

The spectrometer based on the silicon semiconductor detectors for a study of the correlation between two charged particles is described. The results of the time resolution and particles identification measurements are presented. The tests were performed in the proton beam of the JINR synchrocyclotron. (author)

Diffusion proton-proton à petits angles (2° lab 8°) entre 290 et 570 MeV

CERN Document Server

Aebischer, D; Heer, E; Hess, R; Junod, A; Lechanom, C; Nikles, J C; Serre, C; Werren, D W

1972-01-01

Abstract only given. Measurements of the differential cross section for elastic proton-proton scattering in the Coulomb interference region have been made using the CERN synchrocyclotron. The experimental device, consisting essentially of an ensemble of multiwire proportional counters, is described and preliminary results presented.

John Reginald Richardson

International Nuclear Information System (INIS)

Craddock, M.K.

1999-01-01

The recent death of Reg Richardson has robbed the cyclotron community of its most senior figure. His many achievements over a long career include the first demonstration of phase stability, the first synchrocyclotron, the first sector-focused cyclotron, and one of the two cyclotron meson factories. (authors)

The Omicron Spectrometer

CERN Document Server

Allardyce, B W

1976-01-01

It is intended to build a spectrometer with a large solid angle and a large momentum acceptance at the reconstructed synchrocyclotron at CERN. This spectrometer will have an energy resolution of about 1 MeV for particles with momenta up to about 400 MeV/c.

Frank Blythe (1924-2010)

CERN Multimedia

2010-01-01

Frank Blythe, one of the very first engineers engaged in the CERN adventure, passed away on October 22. Born and educated in Salford (England), after a time spent at Metropolitan-Vickers in Manchester, in January 1954 he joined the group at the Nuclear Physics Research Laboratory in Liverpool that was working on the first CERN accelerator, the Synchrocyclotron (SC). At that time CERN had not yet officially been constituted, yet had a well defined work programme, the design and construction work being carried out in various European laboratories. In Liverpool the work included the SC vacuum and cooling system, radiation shielding, experimental areas and beams. By the end of 1954, Frank reached the CERN premises in Geneva, and contributed significantly to the successful construction work of the Synchrocyclotron. He later became responsible for the drawing office and the mechanical workshop (Engineering Group) attached to the MSC Division, and also serving the NP/EP Division. He kept this position until ...

Seen it in the Bulletin? Now see it in real-life!

CERN Multimedia

CERN Bulletin

2013-01-01

Detector Technologies (Map: C4): Read more about the construction and physics of the new NA62 straw chambers in “Straw Detector: 1 - Vacuum: 0”.   The Synchrocyclotron (Map: B2): Read more about the newly opened synchrocyclotron (SC) in “New life for CERN's first accelerator”.   Linac 4 (Map: D4): Visit the site of CERN’s newest linear accelerator: Linac4. Read more about the accelerator in “Linac4: the final assembly stage is under way” (2013), “Testing begins on Linac4” (2012), and “Sixteen silver wires to assemble 350 kg of copper” (2010).   Alpha Magnetic Spectrometer (AMS) (Map: I3): AMS is the most sensitive particle physics spectrometer ever deployed in space. Read about its launch in “AMS: From the ISS to CERN”.   COMPASS (Map: I1): COMPASS is a high-energy physics experiment at the SPS. Read more about its newest phase in ...

Building laboratory capacity to support HIV care in Nigeria: Harvard/APIN PEPFAR, 2004–2012

Science.gov (United States)

Hamel, Donald J.; Sankalé, Jean-Louis; Samuels, Jay Osi; Sarr, Abdoulaye D.; Chaplin, Beth; Ofuche, Eke; Meloni, Seema T.; Okonkwo, Prosper; Kanki, Phyllis J.

2015-01-01

Introduction From 2004–2012, the Harvard/AIDS Prevention Initiative in Nigeria, funded through the US President’s Emergency Plan for AIDS Relief programme, scaled up HIV care and treatment services in Nigeria. We describe the methodologies and collaborative processes developed to improve laboratory capacity significantly in a resource-limited setting. These methods were implemented at 35 clinic and laboratory locations. Methods Systems were established and modified to optimise numerous laboratory processes. These included strategies for clinic selection and management, equipment and reagent procurement, supply chains, laboratory renovations, equipment maintenance, electronic data management, quality development programmes and trainings. Results Over the eight-year programme, laboratories supported 160 000 patients receiving HIV care in Nigeria, delivering over 2.5 million test results, including regular viral load quantitation. External quality assurance systems were established for CD4+ cell count enumeration, blood chemistries and viral load monitoring. Laboratory equipment platforms were improved and standardised and use of point-of-care analysers was expanded. Laboratory training workshops supported laboratories toward increasing staff skills and improving overall quality. Participation in a World Health Organisation-led African laboratory quality improvement system resulted in significant gains in quality measures at five laboratories. Conclusions Targeted implementation of laboratory development processes, during simultaneous scale-up of HIV treatment programmes in a resource-limited setting, can elicit meaningful gains in laboratory quality and capacity. Systems to improve the physical laboratory environment, develop laboratory staff, create improvements to reduce costs and increase quality are available for future health and laboratory strengthening programmes. We hope that the strategies employed may inform and encourage the development of other

CERN: SC-33

International Nuclear Information System (INIS)

Anon.

1991-01-01

On 22 April a forward-looking CERN also looked back for a day, when the 'SC-33' event reviewed the achievements of CERN's first machine, the 600 MeV SynchroCyclotron (SC), which closed down on 17 December after 33 years of valiant service

Nuclear Physics Division progress report for the period 1st April 1975 - 31 March 1976

International Nuclear Information System (INIS)

Gayther, D.B.; Ivanovich, M.; Sanders, L.G.

1976-01-01

The report is in sections entitled: nuclear data and technology for nuclear power; nuclear studies; other studies and applications (Synchrocyclotron Group, Mossbauer Effect Group, Ion-crystal Interactions Group, High Voltage Group, Hydrology and Coastal Sediment Group, Industrial Physics Group); accelerator operation, maintenance and development; reports and publications. (U.K.)

Muse at CERN

CERN Multimedia

CERN Bulletin

2016-01-01

On 19 July, the world-famous, English rock band, Muse, visited CERN before taking centre-stage at Nyon’s Paléo Festival. They toured some of CERN’s installations, including the Synchrocyclotron and the Microcosm exhibition, and also looked in on CMS and the Antimatter Factory.    

VALIDITATION OF A LIGHT QUESTIONNAIRE WITH REAL-LIFE PHOTOPIC ILLUMINANCE MEASUREMENTS: THE HARVARD LIGHT EXPOSURE ASSESSMENT QUESTIONNAIRE

Science.gov (United States)

Bajaj, Archna; Rosner, Bernard; Lockley, Steven; Schernhammer, Eva S.

2011-01-01

Background Light exposure at night is now considered a probable carcinogen. To study the effects of light on chronic diseases like cancer, methods to measure light exposure in large observational studies are needed. We aimed to investigate the validity of self-reported current light exposure. Methods We developed a self-administered semiquantitative light questionnaire, the Harvard Light Exposure Assessment (H-LEA) questionnaire, and compared photopic scores derived from this questionnaire with actual photopic and circadian measures obtained from a real-life 7-day light meter application among 132 women (85 rotating night shift workers and 47 day workers) participating in the Nurses' Health Study II. Results After adjustment for age, BMI, collection day, and night work status, the overall partial Spearman correlation between self-report of light exposure and actual photopic light measurements was 0.72 (P<0.001; Kendall τ =0.57) and 0.73 (P<0.0001; Kendall τ =0.58) when correlating circadian light measurements. There were only minimal differences in accuracy of self-report of light exposure and photopic or circadian light measurement between day (r=0.77 and 0.78, respectively) and rotating night shift workers (r=0.68 and 0.69, respectively). Conclusions The results of this study provide evidence of the criterion validity of self-reported light exposure using the H-LEA questionnaire. Impact: This questionnaire is a practical method of assessing light exposure in large scale epidemiologic studies. PMID:21737411

Nuclear physics division progress report for the period 1st January 1977 to 31st December 1977

International Nuclear Information System (INIS)

Ivanovich, M.; Syme, D.B.; Hartley, N.E.W.

1978-06-01

The report is in sections: nuclear data and technology for nuclear power; nuclear studies; other studies and applications (including sections dealing with the work of the following Groups: Synchrocyclotron, Moessbauer Effect, Ion-Crystal Interaction, High Voltages, Industrial Physics (nuclear techniques, radiation instruments, tracer techniques), Accelerator Operation Maintenance and Development). (U.K.)

The psychopharmacology algorithm project at the Harvard South Shore Program: an algorithm for acute mania.

Science.gov (United States)

Mohammad, Othman; Osser, David N

2014-01-01

This new algorithm for the pharmacotherapy of acute mania was developed by the Psychopharmacology Algorithm Project at the Harvard South Shore Program. The authors conducted a literature search in PubMed and reviewed key studies, other algorithms and guidelines, and their references. Treatments were prioritized considering three main considerations: (1) effectiveness in treating the current episode, (2) preventing potential relapses to depression, and (3) minimizing side effects over the short and long term. The algorithm presupposes that clinicians have made an accurate diagnosis, decided how to manage contributing medical causes (including substance misuse), discontinued antidepressants, and considered the patient's childbearing potential. We propose different algorithms for mixed and nonmixed mania. Patients with mixed mania may be treated first with a second-generation antipsychotic, of which the first choice is quetiapine because of its greater efficacy for depressive symptoms and episodes in bipolar disorder. Valproate and then either lithium or carbamazepine may be added. For nonmixed mania, lithium is the first-line recommendation. A second-generation antipsychotic can be added. Again, quetiapine is favored, but if quetiapine is unacceptable, risperidone is the next choice. Olanzapine is not considered a first-line treatment due to its long-term side effects, but it could be second-line. If the patient, whether mixed or nonmixed, is still refractory to the above medications, then depending on what has already been tried, consider carbamazepine, haloperidol, olanzapine, risperidone, and valproate first tier; aripiprazole, asenapine, and ziprasidone second tier; and clozapine third tier (because of its weaker evidence base and greater side effects). Electroconvulsive therapy may be considered at any point in the algorithm if the patient has a history of positive response or is intolerant of medications.

Building laboratory capacity to support HIV care in Nigeria: Harvard/APIN PEPFAR, 2004–2012

Directory of Open Access Journals (Sweden)

Donald J. Hamel

2015-05-01

Full Text Available Introduction: From 2004–2012, the Harvard/AIDS Prevention Initiative in Nigeria, funded through the US President’s Emergency Plan for AIDS Relief programme, scaled up HIV care and treatment services in Nigeria. We describe the methodologies and collaborative processes developed to improve laboratory capacity significantly in a resource-limited setting. These methods were implemented at 35 clinic and laboratory locations. Methods: Systems were established and modified to optimise numerous laboratory processes. These included strategies for clinic selection and management, equipment and reagent procurement, supply chains, laboratory renovations, equipment maintenance, electronic data management, quality development programmes and trainings. Results: Over the eight-year programme, laboratories supported 160 000 patients receiving HIV care in Nigeria, delivering over 2.5 million test results, including regular viral load quantitation. External quality assurance systems were established for CD4+ cell count enumeration, blood chemistries and viral load monitoring. Laboratory equipment platforms were improved and standardised and use of point-of-care analysers was expanded. Laboratory training workshops supported laboratories toward increasing staff skills and improving overall quality. Participation in a World Health Organisation-led African laboratory quality improvement system resulted in significant gains in quality measures at five laboratories. Conclusions: Targeted implementation of laboratory development processes, during simultaneous scale-up of HIV treatment programmes in a resource-limited setting, can elicit meaningful gains in laboratory quality and capacity. Systems to improve the physical laboratory environment, develop laboratory staff, create improvements to reduce costs and increase quality are available for future health and laboratory strengthening programmes. We hope that the strategies employed may inform

The milestones in patient safety -The Harvard Medical Practice Study I , Study II and Study III

Directory of Open Access Journals (Sweden)

Giuseppe La Torre

2005-12-01

Full Text Available

Over the past decade there has been a steady increase in the number of malpractice claims brought against healthcare providers [1,2] and in the monetary damages awarded to plaintiffs [1,3]. This increase has precipitated numerous state programs designed to moderate the number of claims and encourage providers to develop quality of care initiatives [4,5].

It is important to develop more reliable estimates of the incidence of adverse events and negligence in hospitalized patients.An adverse event is defined as an injury caused by medical management (rather than the underlying disease that prolongs the hospitalization and results in disability at the time of discharge, or both. Negligence is defined as care that has fallen below the standard expected of physicians in their community.

The Harvard Medical Practice Study (HMPS was first published in 1991 and was based on 1984 case records of more than 30,000 randomly selected records from 51 randomly selected acute care, nonpsychiatric hospitals.The study attempts to measure the extent of medical malpractice in hospitals in the state of New York, and compare the resulting patterns with the negligence claims actually filed [6-8]. The HMPS reviews randomly selected records with disability injuries caused by medical treatment.To establish that an adverse event or negligence has occurred, it uses as a criterion an average confidence score of four or more (on a six point scale. Data identified are age, sex, and primary discharge diagnosis. The significance of the differences in rates of adverse events and negligence according to sex and age were tested.

Musiclub

CERN Document Server

Musiclub

2016-01-01

On January 28th, theremin virtuoso Dorit Chrysler came to visit CERN, and played one of her songs, "Avalanche", in the Synchrocyclotron hall. Helped by the media service, the MusiClub produced a short clip of the performance. "Dorit Chrysler with the filming team Ron Suykerbuyk, Django Manglunki and Jacques-Hervé Fichet"

The Annie Jump Cannon Video Project at the Harvard-Smithsonian Center for Astrophysics.

Science.gov (United States)

Lupfer, C.; Welther, B. L.; Griswold, A.

1993-05-01

The heart of this poster paper is the screening of the new 25-minute educational video, ``Annie and the Stars of Many Colors.'' It explores the life and work of Annie Jump Cannon through the eyes of sixth-grade students. A production of the Science Media Group at the CfA, the video was created to interest and inspire girls and minorities, in particular, to continue their study of history and physical science in high school. Recent studies show that science teachers are successfully using videotapes in the classroom to supplement traditional methods of teaching. Other reports show that capable girls and minority students tend to drop science in high school. Our goal, then, was to create a video to stimulate the curiosity and natural interest in science of these younger students. With the help of the Public Affairs Office at the CfA, we arranged to visit local schools to talk to sixth-grade science teachers and their students about the video project. Boys and girls were both eager to participate in it. By lottery, we chose a dozen youngsters of multi-cultural backgrounds to attend a three-day workshop, during which we videotaped them discovering facts about Cannon's childhood and career. Barbara Welther, historian and principal investigator, took the group to the Harvard University Archives to look at some Cannon memorabilia. To learn about spectra, each student assembled a spectroscope from a kit and observed solar lines. CfA astronomers then led the group in various activities to explore the types of stellar spectra that Cannon classified and published in The Henry Draper Catalogue 75 years ago.% and that astronomers still study today. ``Annie and the Stars of Many Colors'' shows young people actively engaged in the process of discovery and offers teachers a novel tool to stimulate discussion of topics in science, history, women's studies, and careers. It is intended for use in schools, libraries, museums, planetariums, as well as for personal interest. For more

Comprehensive MALDI-TOF biotyping of the non-redundant Harvard Pseudomonas aeruginosa PA14 transposon insertion mutant library.

Science.gov (United States)

Oumeraci, Tonio; Jensen, Vanessa; Talbot, Steven R; Hofmann, Winfried; Kostrzewa, Markus; Schlegelberger, Brigitte; von Neuhoff, Nils; Häussler, Susanne

2015-01-01

Pseudomonas aeruginosa is a gram-negative bacterium that is ubiquitously present in the aerobic biosphere. As an antibiotic-resistant facultative pathogen, it is a major cause of hospital-acquired infections. Its rapid and accurate identification is crucial in clinical and therapeutic environments. In a large-scale MALDI-TOF mass spectrometry-based screen of the Harvard transposon insertion mutant library of P. aeruginosa strain PA14, intact-cell proteome profile spectra of 5547 PA14 transposon mutants exhibiting a plethora of different phenotypes were acquired and analyzed. Of all P. aeruginosa PA14 mutant profiles 99.7% were correctly identified as P. aeruginosa with the Biotyper software on the species level. On the strain level, 99.99% of the profiles were mapped to five different individual P. aeruginosa Biotyper database entries. A principal component analysis-based approach was used to determine the most important discriminatory mass features between these Biotyper groups. Although technical replicas were consistently categorized to specific Biotyper groups in 94.2% of the mutant profiles, biological replicas were not, indicating that the distinct proteotypes are affected by growth conditions. The PA14 mutant profile collection presented here constitutes the largest coherent P. aeruginosa MALDI-TOF spectral dataset publicly available today. Transposon insertions in thousands of different P. aeruginosa genes did not affect species identification from MALDI-TOF mass spectra, clearly demonstrating the robustness of the approach. However, the assignment of the individual spectra to sub-groups proved to be non-consistent in biological replicas, indicating that the differentiation between biotyper groups in this nosocomial pathogen is unassured.

From the Harvard Medical Practice Study to the Luxembourg Declaration. Changes in the approach to patient safety. Closing remarks

Directory of Open Access Journals (Sweden)

Gianfranco Damiani

2005-12-01

Full Text Available Since the Harvard Medical Practice Study was published in 1991 the growing mass of international literature has demonstrated that medical adverse events can cause iatrogenic illnesses, prolonged hospitalisations and increased costs. In 1999-2001, reports made by the Institute of Medicine (IOM in the USA, the Department of Health (DoH in the UK and the Australian Patient Safety Foundation (APSF stressed the necessity for creating a safer environment and a reporting culture throughout healthcare systems. They also emphasized the need for researchers to investigate means of turning policies into practice. Since their publication a lot of effort has gone into collecting data on adverse events and near misses. As a result, in 2001, the AHRQ published a Health Technology Assessment report on best practices for patient safety. While in Australia national meetings have been dedicated to address important issues across the whole spectrum of healthcare. In the UK the Audit Commission has published a report that is also focused on medication safety: “A spoonful of sugar”. In 2004 the World Health Organisation promoted a Patient Safety Alliance; while in April 2005the Standing Committee of European Doctors organised a Conference in Luxembourg called “Patient safety - Making it happen!”. The issue of patient safety is therefore seen as a priority by EU institutional bodies and by many European health stakeholders.

Experiment list: SRX150684 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available sue Diagnosis=Fibrocystic Disease 174026370,97.9,12.7,1654 GSM935605: Harvard ChipSeq MCF10A-Er-Src Input Harvard... Control source_name=MCF10A-Er-Src || biomaterial_provider=Struhl laboratory || lab=Harvard || lab description=Struhl - Harvard...before peaks are called. || control=Harvard_Control || control description=input library was prepared at Harvard. || control=Harvard..._Control || control description=input library was prepared at Harvard. || controlid=

Nuclear Physics Division Progress Report for the period 1st April 1976 to 31 December 1976

International Nuclear Information System (INIS)

Ivanovich, M.; Sanders, L.G.; Syme, D.B.

1977-05-01

The main contents of the report are as follows: nuclear data and technology for nuclear power; nuclear studies; other studies and applications (Synchrocyclotron Group, Moessbauer Effect Group, Ion-Crystal Interactions Group, High Voltage Group, Hydrology and Coastal Sediment Group, Industrial Physics Group); accelerator operation, maintenance and development; reports, publications and conference papers. (U.K.)

Rotary capacitor

CERN Multimedia

CERN PhotoLab

1971-01-01

The rotating wheel of the rotary capacitor representing the most critical part of the new radio-frequency system of the synchro-cyclotron. The three rows of teeth on the circumference of the wheel pass between four rows of stator blades with a minimum clearance of 1 mm at a velocity of 1700 rev/min.

ISOLDE 1985-1987: In the shadow of LEP construction

CERN Multimedia

CERN. Geneva

2014-01-01

This report describes my time at CERN from 1985 to 1987. Only very briefly before, ISOLDE was recognized by the CERN Management as a CERN facility and not only as a collaboration performing experiments at the synchrocyclotron (SC). Due to LEP construction the human resources were extremely restricted and I acted in one person as ISOLDE Group Leader, as Coordinator of the Synchrocyclotron, and as person responsible for the ISOLDE Technical Group. In addition, I was responsible for the students of my research groups from Mainz University which were active in laser spectroscopy of neutron-deficient nuclides in the mercury region and in getting ISOLTRAP on the floor and into operation. Due to LEP construction also the financial resources were extremely limited and my requests to the EP Division Leader B. Hyams and to the Director General H. Schopper for financial support for installation of a laser ion source and ISOLTRAP were turned down. Still, I and my students had a lot of fun at ISOLDE and I am very happy th...

Stemcell Information: SKIP000915 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available s Immunostaining ... Yes Teratoma formation ... Salvatore Iovino Salvatore Iovino Harvard... Medical School Harvard Medical School Harvard Medical School Harvard Medical School C. Rona...ld Kahn C. Ronald Kahn Not Available Harvard Medical School Harvard Medical School ... 26831110 10.1073/pna

Stemcell Information: SKIP000914 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available ining ... Yes Teratoma formation ... Salvatore Iovino Salvatore Iovino Harvard Medical School Harv...ard Medical School Harvard Medical School Harvard Medical School C. Ronald Kahn C. ...Ronald Kahn Not Available Harvard Medical School Harvard Medical School ... 26831110 10.1073/pnas.152566511

Stemcell Information: SKIP000913 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available unostaining ... Yes Teratoma formation ... Salvatore Iovino Salvatore Iovino Harvard... Medical School Harvard Medical School Harvard Medical School Harvard Medical School C. Ronald Ka...hn C. Ronald Kahn Not Available Harvard Medical School Harvard Medical School ... 26831110 10.1073/pnas.152

Evaluation of statistical designs in phase I expansion cohorts: the Dana-Farber/Harvard Cancer Center experience.

Science.gov (United States)

Dahlberg, Suzanne E; Shapiro, Geoffrey I; Clark, Jeffrey W; Johnson, Bruce E

2014-07-01

Phase I trials have traditionally been designed to assess toxicity and establish phase II doses with dose-finding studies and expansion cohorts but are frequently exceeding the traditional sample size to further assess endpoints in specific patient subsets. The scientific objectives of phase I expansion cohorts and their evolving role in the current era of targeted therapies have yet to be systematically examined. Adult therapeutic phase I trials opened within Dana-Farber/Harvard Cancer Center (DF/HCC) from 1988 to 2012 were identified for sample size details. Statistical designs and study objectives of those submitted in 2011 were reviewed for expansion cohort details. Five hundred twenty-two adult therapeutic phase I trials were identified during the 25 years. The average sample size of a phase I study has increased from 33.8 patients to 73.1 patients over that time. The proportion of trials with planned enrollment of 50 or fewer patients dropped from 93.0% during the time period 1988 to 1992 to 46.0% between 2008 and 2012; at the same time, the proportion of trials enrolling 51 to 100 patients and more than 100 patients increased from 5.3% and 1.8%, respectively, to 40.5% and 13.5% (χ(2) test, two-sided P < .001). Sixteen of the 60 trials (26.7%) in 2011 enrolled patients to three or more sub-cohorts in the expansion phase. Sixty percent of studies provided no statistical justification of the sample size, although 91.7% of trials stated response as an objective. Our data suggest that phase I studies have dramatically changed in size and scientific scope within the last decade. Additional studies addressing the implications of this trend on research processes, ethical concerns, and resource burden are needed. © The Author 2014. Published by Oxford University Press. All rights reserved.

Stemcell Information: SKIP000912 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available ing ... Yes Teratoma formation ... Salvatore Iovino Salvatore Iovino Harvard Medical School Harvar...d Medical School Harvard Medical School Harvard Medical School C. Ronald Kahn C. Ro...nald Kahn Information Only Harvard Medical School Harvard Medical School ... 26831110 10.1073/pnas.15256651

Association Between National Board Dental Examination Part II Scores and Comprehensive Examinations at Harvard School of Dental Medicine.

Science.gov (United States)

Lee, Min Kyeong; Allareddy, Veerasathpurush; Howell, T Howard; Karimbux, Nadeem Y

2011-01-01

Harvard School of Dental Medicine (HSDM) uses a hybrid problem-based approach to teaching in the predoctoral program. The objective structured clinical examination (OSCE) is a formative examination designed to assess the performance of students in the problem-based learning (PBL) curriculum. At HSDM three comprehensive examinations with OSCE components are administered during the third and fourth years of clinical training. The National Board Dental Examination (NBDE) Part II is taken in the final year of the predoctoral program. This study examines the association between the NBDE Part II and the comprehensive exams held at HSDM. Predoctoral students from the HSDM classes of 2005 and 2006 were included in this study. The outcome variable of interest was the scores obtained by students in the NBDE Part II, and the main independent variable of interest was the performance of students in the comprehensive exams (honors, pass, make-up exam to pass). The Mann-Whitney U-test was used to examine the association between the grades obtained in the each of the three comprehensive exams and the NBDE Part II scores. Multivariable linear regression analysis was also used to examine the association between the NBDE Part II scores and the comprehensive exam grades. The effect of potential confounding factors including age, sex, and race/ethnicity was adjusted. The results suggest that students who performed well in the comprehensive exams performed better on the NBDE Part II, even after adjusting for confounding factors. Future studies will examine the long-term impact of PBL on postdoctoral plans and career choices.

Experiment list: SRX150478 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available osis=Fibrocystic Disease 66690540,98.1,24.9,110111 GSM935398: Harvard ChipSeq MCF10A-Er-Src 4OHTAM 1uM 12hr c-Fos Harvard... Control source_name=MCF10A-Er-Src || biomaterial_provider=Struhl laboratory || lab=Harvard || ...lab description=Struhl - Harvard University || datatype=ChipSeq || datatype descr... is a leucine-zipper. || antibody vendorname=Santa Cruz Biotech || antibody vendorid=sc-7202 || control=Harvard..._Control || control description=input library was prepared at Harvard. || control=Harvard

Transport of one SC coil through the village of Meyrin

CERN Multimedia

1956-01-01

The energizing coils of the Synchro-cyclotron magnet were manufactured in Belgium before travelling to Basel in Switzerland by boat and continuing by road to Geneva. The first coil reached Geneva in December 1955, with the second following in early 1956. The coils were stored in a hangar at the Geneva airport before they were brought to CERN in May 1956.

Experiments at the time-of-flight neutron spectrometer GNEIS in Gatchina

International Nuclear Information System (INIS)

Shcherbakov, O.A.

1990-01-01

A brief description of the Gatchina neutron time-of-flight spectrometer GNEIS at the 1 GeV proton synchrocyclotron and its main characteristics are given. Some results of the nuclear fission experiments and neutron cross section measurements are presented not only to illustrate the facility performance but to outline the basic directions of the researches as well. 28 refs.; 10 figs

Accelerator and Fusion Research Division. Annual report, October 1978-September 1979

International Nuclear Information System (INIS)

1980-03-01

Topics covered include: Super HILAC and Bevalac operations; high intensity uranium beams line item; advanced high charge state ion source; 184-inch synchrocyclotron; VENUS project; positron-electron project; high field superconducting accelerator magnets; beam cooling; accelerator theory; induction linac drivers; RF linacs and storage rings; theory; neutral beam systems development; experimental atomic physics; neutral beam plasma research; plasma theory; and the Tormac project

Experiment list: SRX150477 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available osis=Fibrocystic Disease 70636654,97.7,24.3,106225 GSM935397: Harvard ChipSeq MCF10A-Er-Src 4OHTAM 1uM 4hr c-Fos Harvard... Control source_name=MCF10A-Er-Src || biomaterial_provider=Struhl laboratory || lab=Harvard || l... a leucine-zipper. || antibody vendorname=Santa Cruz Biotech || antibody vendorid=sc-7202 || control=Harvard..._Control || control description=input library was prepared at Harvard. || control=Harvard..._Control || control description=input library was prepared at Harvard. || controlid=wgEncodeEH002871

Experiment list: SRX150476 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available osis=Fibrocystic Disease 60050220,94.5,18.5,85444 GSM935396: Harvard ChipSeq MCF10A-Er-Src 4OHTAM 1uM 36hr c-Fos Harvard... Control source_name=MCF10A-Er-Src || biomaterial_provider=Struhl laboratory || lab=Harvard || l...is a leucine-zipper. || antibody vendorname=Santa Cruz Biotech || antibody vendorid=sc-7202 || control=Harvard..._Control || control description=input library was prepared at Harvard. || control=Harvard..._Control || control description=input library was prepared at Harvard. || controlid=wgEncodeEH0028

The Harvard Automated Processing Pipeline for Electroencephalography (HAPPE): Standardized Processing Software for Developmental and High-Artifact Data.

Science.gov (United States)

Gabard-Durnam, Laurel J; Mendez Leal, Adriana S; Wilkinson, Carol L; Levin, April R

2018-01-01

Electroenchephalography (EEG) recordings collected with developmental populations present particular challenges from a data processing perspective. These EEGs have a high degree of artifact contamination and often short recording lengths. As both sample sizes and EEG channel densities increase, traditional processing approaches like manual data rejection are becoming unsustainable. Moreover, such subjective approaches preclude standardized metrics of data quality, despite the heightened importance of such measures for EEGs with high rates of initial artifact contamination. There is presently a paucity of automated resources for processing these EEG data and no consistent reporting of data quality measures. To address these challenges, we propose the Harvard Automated Processing Pipeline for EEG (HAPPE) as a standardized, automated pipeline compatible with EEG recordings of variable lengths and artifact contamination levels, including high-artifact and short EEG recordings from young children or those with neurodevelopmental disorders. HAPPE processes event-related and resting-state EEG data from raw files through a series of filtering, artifact rejection, and re-referencing steps to processed EEG suitable for time-frequency-domain analyses. HAPPE also includes a post-processing report of data quality metrics to facilitate the evaluation and reporting of data quality in a standardized manner. Here, we describe each processing step in HAPPE, perform an example analysis with EEG files we have made freely available, and show that HAPPE outperforms seven alternative, widely-used processing approaches. HAPPE removes more artifact than all alternative approaches while simultaneously preserving greater or equivalent amounts of EEG signal in almost all instances. We also provide distributions of HAPPE's data quality metrics in an 867 file dataset as a reference distribution and in support of HAPPE's performance across EEG data with variable artifact contamination and

The Harvard Automated Processing Pipeline for Electroencephalography (HAPPE: Standardized Processing Software for Developmental and High-Artifact Data

Directory of Open Access Journals (Sweden)

Laurel J. Gabard-Durnam

2018-02-01

Full Text Available Electroenchephalography (EEG recordings collected with developmental populations present particular challenges from a data processing perspective. These EEGs have a high degree of artifact contamination and often short recording lengths. As both sample sizes and EEG channel densities increase, traditional processing approaches like manual data rejection are becoming unsustainable. Moreover, such subjective approaches preclude standardized metrics of data quality, despite the heightened importance of such measures for EEGs with high rates of initial artifact contamination. There is presently a paucity of automated resources for processing these EEG data and no consistent reporting of data quality measures. To address these challenges, we propose the Harvard Automated Processing Pipeline for EEG (HAPPE as a standardized, automated pipeline compatible with EEG recordings of variable lengths and artifact contamination levels, including high-artifact and short EEG recordings from young children or those with neurodevelopmental disorders. HAPPE processes event-related and resting-state EEG data from raw files through a series of filtering, artifact rejection, and re-referencing steps to processed EEG suitable for time-frequency-domain analyses. HAPPE also includes a post-processing report of data quality metrics to facilitate the evaluation and reporting of data quality in a standardized manner. Here, we describe each processing step in HAPPE, perform an example analysis with EEG files we have made freely available, and show that HAPPE outperforms seven alternative, widely-used processing approaches. HAPPE removes more artifact than all alternative approaches while simultaneously preserving greater or equivalent amounts of EEG signal in almost all instances. We also provide distributions of HAPPE's data quality metrics in an 867 file dataset as a reference distribution and in support of HAPPE's performance across EEG data with variable artifact

Experiment list: SRX150517 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available osis=Fibrocystic Disease 50667127,93.3,23.9,80828 GSM935438: Harvard ChipSeq MCF10A-Er-Src EtOH 0.01pct c-Fos Harvard... Control source_name=MCF10A-Er-Src || biomaterial_provider=Struhl laboratory || lab=Harvard || lab description=Struhl - Harv...me=Santa Cruz Biotech || antibody vendorid=sc-7202 || control=Harvard_Control || control description=input l...ibrary was prepared at Harvard. || control=Harvard_Control || control description...=input library was prepared at Harvard. || controlid=wgEncodeEH002871 || replicate=1 http://dbarchive.biosci

Experiment list: SRX150570 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available osis=Fibrocystic Disease 64692659,93.8,19.3,37417 GSM935491: Harvard ChipSeq MCF10A-Er-Src 4OHTAM 1uM 4hr c-Myc Harvard... Control source_name=MCF10A-Er-Src || biomaterial_provider=Struhl laboratory || lab=Harvard || la...ntibody vendorname=Santa Cruz Biotech || antibody vendorid=sc-764 || control=Harvard_Control || control desc...ription=input library was prepared at Harvard. || control=Harvard_Control || cont...rol description=input library was prepared at Harvard. || controlid=wgEncodeEH002871 || replicate=1 http://d

Impact of severe ADAMTS13 deficiency on clinical presentation and outcomes in patients with thrombotic microangiopathies: the experience of the Harvard TMA Research Collaborative.

Science.gov (United States)

Bendapudi, Pavan K; Li, Ang; Hamdan, Ayad; Uhl, Lynne; Kaufman, Richard; Stowell, Christopher; Dzik, Walter; Makar, Robert S

2015-12-01

The Harvard TMA Research Collaborative is a multi-institutional registry-based effort to study thrombotic microangiopathies (TMA). Laboratory and clinical parameters were recorded for 254 cases of suspected autoimmune thrombotic thrombocytopenic purpura (TTP). Patients with severe ADAMTS13 deficiency (activity ≤10%, N = 68) were more likely to be young, female and without a history of cancer treatment or transplantation. While all patients with severe deficiency were diagnosed with autoimmune TTP, those without severe deficiency frequently had disseminated intravascular coagulation, drug-associated TMA and transplant-related TMA. Patients with severe ADAMTS13 deficiency had superior overall survival at 360 d compared to those without severe deficiency (93·0% vs. 47·5%, P 10% varied significantly across the institutions in our consortium (13·2-63·8%, P 10% between the three hospitals (P = 0·98). Our data show that patients with severe ADAMTS13 deficiency represent a clinically distinct cohort that responds well to TPE. In contrast, TMA without severe ADAMTS13 deficiency is associated with increased mortality that may not be influenced by TPE. © 2015 John Wiley & Sons Ltd.

Enrico Fermi: The First Chain Reactor (with Film) and Pion-Proton Scattering

International Nuclear Information System (INIS)

Martin, Ron

2003-01-01

A twenty minute film will be shown depicting the first nuclear chain reactor at the University of Chicago on December 2, 1942. The film was made of a re-enactment in 1952 and is narrated by Arthur Compton and Enrico Fermi. After the film, Ronald Martin will talk about his experiences on pion-proton scattering with Enrico Fermi at the Chicago synchrocyclotron in the fifties.

Precise measurements of mass of Rb isotopes with A=91-97

International Nuclear Information System (INIS)

Alkhazov, G.D.; Belyaev, B.N.; Domkin, V.D.; Korobulin, Yu.G.; Lukashevich, V.V.; Mukhin, V.S.; AN SSSR, Leningrad

1989-01-01

A new scheme of the experiment on measuring the short-living nuclide atom masses, based on applying the isobar doublet method for mass scale gauging, is proposed. Results of measuring masses of Rb isotope atom with A=91-97, performed using a prism mass-spectrometer on line with the LiYaF mass-separator and synchrocyclotron with 30-80 keV error are presented

Experiment list: SRX150520 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available osis=Fibrocystic Disease 49296691,89.4,24.9,46885 GSM935441: Harvard ChipSeq MCF10A-Er-Src EtOH 0.01pct c-Myc Harvard... Control source_name=MCF10A-Er-Src || biomaterial_provider=Struhl laboratory || lab=Harvard || lab description=Struhl - Harv...|| antibody vendorid=sc-764 || control=Harvard_Control || control description=input library was prepared at Harvard. || control=Harva...rd_Control || control description=input library was prepared at Harvard...ard University || datatype=ChipSeq || datatype descripti

Thirty-three years of physics at the CERN synchro-cyclotron

International Nuclear Information System (INIS)

Fidecaro, G.

1993-01-01

The SC33 Symposium was organized as a series of invited talks, each one summarizing a particular aspect of the research life of the SC. In the short time available it would have been impossible to have talks on each of the many subjects dealt with in the 33-year lifetime of the SC, and we apologize if not all the subjects could be covered by the speakers. The Symposium was also intended to be an occasion for a gathering of all those who took part in the construction of the SC, and all those who, over a period of 33 years, contributed to the research work at the SC, and in fact a considerable effort was put into searching for names and addresses of people who had been working at the SC decades ago and who could still be reached, starting from unfortunately incomplete lists of publications. (orig.)

A study of the importance of education and cost incentives on individual food choices at the Harvard School of Public Health cafeteria.

Science.gov (United States)

Michels, Karin B; Bloom, Barry R; Riccardi, Paul; Rosner, Bernard A; Willett, Walter C

2008-02-01

To investigate the importance of cost and awareness of health- or disease-promoting properties of foods and meals for choices by customers of a cafeteria. A non-randomized intervention study. A medium size cafeteria in the Harvard School of Public Health. Customers of the cafeteria mainly consisting of public health students, faculty, and school staff and workers from the medical campus. The purchase of healthy foods and dishes was subsidized and their prices reduced by 20%. This promotion was accompanied by the distribution of educational material. Change in consumption of healthy and less healthy foods. The geometric mean was used to calculate the change in consumption. During the intervention, we observed a 6% increase in the consumption of healthy foods (95% confidence interval [CI]; 5% to 8%), and a 2% decline in the consumption of less-healthy foods (95% CI; -1% to -4%). After the prices returned to their original levels, the consumption of healthy foods increased further to 17% (95% CI; 13% to 20%) and a 2% decline in the consumption of less-healthy foods (95% CI; % 1 to -5%) persisted. Subsidizing healthful meals and educating consumers about the importance of a healthy diet can result in a modest increase in the selection of healthy foods and meals that can be maintained beyond the periods of subsidy and promotion.

Comparison of Elastic Modulus and Compressive Strength of Ariadent and Harvard Polycarboxylate Cement and Vitremer Resin Modified Glass Ionomer

Directory of Open Access Journals (Sweden)

Ahmadian Khoshemehr Leila

2009-09-01

Full Text Available Background: Luting agents are used to attach indirect restoration into or on the tooth. Poor mechanical properties of cement may be a cause of fracture of this layer and lead to caries and restoration removal. The purpose of this study was to compare the elastic modulus and compressive strength of Ariadent (A Poly and Harvard polycarboxylate (H Poly cements and Vitremer resin modified glass ionomer (RGl.Materials & Methods: In this experimental study 15 specimens were prepared form each experimental cement in Laboratory of Tehran Oil Refining Company. The cylindrical specimens were compressed in Instron machine after 24 hours. Elastic modulus and compressive strength were calculated from stress/strain curve of each specimen. One way ANOVA and Tukey tests were used for statistical analysis and P values<0.05 were considered to be statistically significant.Results: The mean elastic modulus and mean compressive strength were 2.2 GPa and 87.8MPa in H poly, 2.4 GPa and 56.5 MPa in A Poly, and 0.8GPa and 105.6 MPa in RGI, respectively. Statistical analysis showed that compressive strength and elastic modulus of both polycarboxylate cements were significantly different from hybrid ionomer (P<0.05, but the difference between elastic modulus of two types of polycarboxilate cements was not statistically significant. Compressive strength of two polycarboxilate cements were significantly different (P<0.05. Conclusion: An ideal lutting agent must have the best mechanical properties. Between the tested luttins RGl cement had the lowest elastic modulus and the highest compressive strength, but the A poly cement had the highest elastic modulus and the lowest compressive strength. Therefore none of them was the best.

Production cross sections and isomeric ratios for sup(110m)In/sup(110g)In formed in Cd (d,xn) reactions

International Nuclear Information System (INIS)

Herreros Usher, Oscar; Maceiras de Jefimowicz, Elena; De la Vega Vedoya, Mario; Jorge Nassiff, Sonia

1980-01-01

Excitation functions and isomeric cross sections ratios have been measured for the 110 Cd (d,2n) and 111 Cd (d,3n) reactions in which the isomeric pair sup(110m)In/sup(110g)In is produced. Activation method was employed and the irradiations were performed at the synchrocyclotron of the Comision Nacional de Energia Atomica, Argentina, with an incident energy of 27.MeV. (author) [es

Calibration of a large multi-element neutron counter in the energy range 85-430 MeV

CERN Document Server

Strong, J A; Esterling, R J; Garvey, J; Green, M G; Harnew, N; Jane, M R; Jobes, M; Mawson, J; McMahon, T; Robertson, A W; Thomas, D H

1978-01-01

Describes the calibration of a large 60 element neutron counter with a threshold of 2.7 MeV equivalent electron energy. The performance of the counter has been measured in the neutron kinetic energy range 8.5-430 MeV using a neutron beam at the CERN Synchrocyclotron. The results obtained for the efficiency as a function of energy are in reasonable agreement with a Monte Carlo calculation. (7 refs).

Experiments at CERN in 1986

International Nuclear Information System (INIS)

1986-11-01

This report is a compilation of the current experimental programme at CERN. The experiments listed are being performed at one of the following machines: The Super Proton Synchrotron, the Proton Synchrotron and the Synchro-Cyclotron. The four experiments planned for the Large Electron Positron machine are also listed. Each experiment is briefly described and a schematic layout of its apparatus is included, together with lists of participants and institutions. (orig./HSI)

Experiments at CERN in 1984

International Nuclear Information System (INIS)

1984-11-01

This book is a compilation of the current experimental program at CERN. The experiments listed are being performed at one of the following machines: the Super Proton Synchrotron (SPS), the Proton Synchrotron (PS) and the Synchro-Cyclotron (SC). The Intersecting Storage Rings (ISR) have ceased functioning early this year. The four approved experiments to be done by means of the Large Electron Positron machine (LEP) are also listed. (orig./HSI)

Production of high specific activity /sup 123/I for protein iodination for medical use

Energy Technology Data Exchange (ETDEWEB)

Legoux, Y; Cieur, M [Paris-11 Univ., 91 - Orsay (France). Inst. de Physique Nucleaire; Goutheraud, R; Drouet, J [Centre National de Transfusion Sanguine, 75 - Paris (France); Crouzel, C; Syrota, A [CEA, 91 - Orsay (France). Service Hospitalier Frederic Joliot

1985-01-01

Iodine-123 is produced via xenon-133 by irradiation of a sodium iodide target with 108 MeV deuterons from the synchrocyclotron of IPN. The on-line production method is described. The specific activity of the iodine is determined by neutron activation analysis and by a radioimmunological method. The conditions labelling different proteins (insulin, angiotensin) are given and also the purification method to obtain a product ready for injection to patients.

Intermediate energy heavy ion reactions. A program for CELSIUS

International Nuclear Information System (INIS)

Jakobsson, B.

1986-02-01

The accelerator system under construction in Uppsala with the ECR-source + the K equals 200 synchrocyclotron + the CELSIUS synchrotron ring for storage, cooling and acceleration opens up possibilities for a very fruitful heavy ion physics program. Some recently obtained results and some recent ideas on intermediate energy reactions are discussed and speculations are made about some experiments where the unconventional qualities of CELSIUS beams could be utilized. (author)

Policies to increase the social value of science and the scientist satisfaction. An exploratory survey among Harvard bioscientists. [v1; ref status: indexed, http://f1000r.es/2iq

Directory of Open Access Journals (Sweden)

Andrea Ballabeni

2014-01-01

Full Text Available Basic research in the biomedical field generates both knowledge that has a value per se regardless of its possible practical outcome and that has the potential to produce more practical benefits. Policies can increase the benefit potential to society of basic biomedical research by offering various kinds of incentives to basic researchers. In this paper we argue that soft incentives or “nudges” are particularly promising. However, to be well designed, these incentives must take into account the motivations, goals and views of the basic scientists. In the paper we present the results of an investigation that involved more than 300 scientists at Harvard Medical School and affiliated institutes. The study shows that basic researchers’ support for soft incentives is such that the transformative value of fundamental investigations can be increased without affecting the spirit of the basic research and scientists’ work satisfaction. After discussing the findings, we suggest a few examples of nudges and discuss one in more detail.

Policies to increase the social value of science and the scientist satisfaction. An exploratory survey among Harvard bioscientists. [v2; ref status: indexed, http://f1000r.es/3jw

Directory of Open Access Journals (Sweden)

Andrea Ballabeni

2014-06-01

Full Text Available Basic research in the biomedical field generates both knowledge that has a value per se regardless of its possible practical outcome and knowledge that has the potential to produce more practical benefits. Policies can increase the benefit potential to society of basic biomedical research by offering various kinds of incentives to basic researchers. In this paper we argue that soft incentives or “nudges” are particularly promising. However, to be well designed, these incentives must take into account the motivations, goals and views of the basic scientists. In the paper we present the results of an investigation that involved more than 300 scientists at Harvard Medical School and affiliated institutes. The results of this study suggest that some soft incentives could be valuable tools to increase the transformative value of fundamental investigations without affecting the spirit of the basic research and scientists’ work satisfaction. After discussing the findings, we discuss a few examples of nudges for basic researchers in the biomedical fields.

INFLUENCE OF THE INTELLIGENCE PROJECT AT HARVARD COGNITIVE DEVELOPMENT OF STUDENTS IN PRIMARY EDUCATION. IMPLICATIONS FOR ORGANIZATIONAL AND PROFESSIONAL DEVELOPMENT IN SECOND AND THIRD CYCLE OF PRIMARY EDUCATION

Directory of Open Access Journals (Sweden)

Mercedes Ramos Fresno

2014-12-01

Full Text Available This study aims to identify the influence of the Harvard Project on IQ Intelligence students of second and third cycle of primary education and the implications for the organizational and professional development of teachers . The experience has been developed over four courses in a public school in Madrid. The methodology used , complementary , included group designs with pretest-posttest measures , participant observation and interviews. The results show the positive impact of PIH on IQ and can say that the application of PIH produce cognitive improvements in students , as measured by the intelligence test "g" of Cattell . Regarding the implications for the organizational and professional development, we have found that the implementation of PIH promotes the development of teacher professional autonomy , commitment to teaching practice , and the necessary self-criticism to constantly evaluate , creating flexible educational proposals through self-reflection. The communication of this experience positively influences both the school community and the local community, encouraging them to participate in educational projects aimed at improving the quality of teaching- learning and education.

The Power of Exercise and the Exercise of Power: The Harvard Fatigue Laboratory, Distance Running, and the Disappearance of Work, 1919-1947.

Science.gov (United States)

Scheffler, Robin Wolfe

2015-08-01

In the early twentieth century, fatigue research marked an area of conflicting scientific, industrial, and cultural understandings of working bodies. These different understandings of the working body marked a key site of political conflict during the growth of industrial capitalism. Many fatigue researchers understood fatigue to be a physiological fact and allied themselves with Progressive-era reformers in urging industrial regulation. Opposed to these researchers were advocates of Taylorism and scientific management, who held that fatigue was a mental event and that productivity could be perpetually increased through managerial efficiency. Histories of this conflict typically cease with the end of the First World War, when it is assumed that industrial fatigue research withered away. This article extends the history of fatigue research through examining the activities of the Harvard Fatigue Laboratory in the 1920s and 1930s. The Laboratory developed sophisticated biochemical techniques to study the blood of exercising individuals. In particular, it found that exercising individuals could attain a biochemically "steady state," or equilibrium, and extrapolated from this to assert that fatigue was psychological, not physiological, in nature. In contrast to Progressive-era research, the Laboratory reached this conclusion through laboratory examination, not of industrial workers, but of Laboratory staff members and champion marathon runners. The translation of laboratory research to industrial settings, and the eventual erasure of physiological fatigue from discussions of labor, was a complex function of institutional settings, scientific innovation, and the cultural meanings of work and sport.

A Study of the Importance of Education and Cost Incentives on Individual Food Choices at the Harvard School of Public Health Cafeteria

Science.gov (United States)

Michels, Karin B.; Bloom, Barry R.; Riccardi, Paul; Rosner, Bernard A.; Willett, Walter C.

2013-01-01

Objectives To investigate the importance of cost and awareness of health- or disease-promoting properties of foods and meals for choices by customers of a cafeteria. Design A non-randomized intervention study. Setting A medium size cafeteria in the Harvard School of Public Health. Participants Customers of the cafeteria mainly consisting of public health students, faculty, and school staff and workers from the medical campus. Intervention The purchase of healthy foods and dishes was subsidized and their prices reduced by 20%. This promotion was accompanied by the distribution of educational material. Main Outcome Measures Change in consumption of healthy and less healthy foods. Analysis The geometric mean was used to calculate the change in consumption. Results During the intervention, we observed a 6% increase in the consumption of healthy foods (95% confidence interval [CI]; 5% to 8%), and a 2% decline in the consumption of less-healthy foods (95% CI; −1% to −4%). After the prices returned to their original levels, the consumption of healthy foods increased further to 17% (95% CI; 13% to 20%) and a 2% decline in the consumption of less-healthy foods (95% CI; % 1 to −5%) persisted. Conclusions Subsidizing healthful meals and educating consumers about the importance of a healthy diet can result in a modest increase in the selection of healthy foods and meals that can be maintained beyond the periods of subsidy and promotion. PMID:18460476

TH-CD-201-10: Highly Efficient Synchronized High-Speed Scintillation Camera System for Measuring Proton Range, SOBP and Dose Distributions in a 2D-Plane

International Nuclear Information System (INIS)

Goddu, S; Sun, B; Grantham, K; Zhao, T; Zhang, T; Bradley, J; Mutic, S

2016-01-01

Purpose: Proton therapy (PT) delivery is complex and extremely dynamic. Therefore, quality assurance testing is vital, but highly time-consuming. We have developed a High-Speed Scintillation-Camera-System (HS-SCS) for simultaneously measuring multiple beam characteristics. Methods: High-speed camera was placed in a light-tight housing and dual-layer neutron shield. HS-SCS is synchronized with a synchrocyclotron to capture individual proton-beam-pulses (PBPs) at ∼504 frames/sec. The PBPs from synchrocyclotron trigger the HS-SCS to open its shutter for programmed exposure-time. Light emissions within 30×30×5cm3 plastic-scintillator (BC-408) were captured by a CCD-camera as individual images revealing dose-deposition in a 2D-plane with a resolution of 0.7mm for range and SOBP measurements and 1.67mm for profiles. The CCD response as well as signal to noise ratio (SNR) was characterized for varying exposure times, gains for different light intensities using a TV-Optoliner system. Software tools were developed to analyze ∼5000 images to extract different beam parameters. Quenching correction-factors were established by comparing scintillation Bragg-Peaks with water scanned ionization-chamber measurements. Quenching corrected Bragg-peaks were integrated to ascertain proton-beam range (PBR), width of Spared-Out-Bragg-Peak (MOD) and distal

TH-CD-201-10: Highly Efficient Synchronized High-Speed Scintillation Camera System for Measuring Proton Range, SOBP and Dose Distributions in a 2D-Plane

Energy Technology Data Exchange (ETDEWEB)

Goddu, S; Sun, B; Grantham, K; Zhao, T; Zhang, T; Bradley, J; Mutic, S [Washington University School of Medicine, Saint Louis, MO (United States)

2016-06-15

Purpose: Proton therapy (PT) delivery is complex and extremely dynamic. Therefore, quality assurance testing is vital, but highly time-consuming. We have developed a High-Speed Scintillation-Camera-System (HS-SCS) for simultaneously measuring multiple beam characteristics. Methods: High-speed camera was placed in a light-tight housing and dual-layer neutron shield. HS-SCS is synchronized with a synchrocyclotron to capture individual proton-beam-pulses (PBPs) at ∼504 frames/sec. The PBPs from synchrocyclotron trigger the HS-SCS to open its shutter for programmed exposure-time. Light emissions within 30×30×5cm3 plastic-scintillator (BC-408) were captured by a CCD-camera as individual images revealing dose-deposition in a 2D-plane with a resolution of 0.7mm for range and SOBP measurements and 1.67mm for profiles. The CCD response as well as signal to noise ratio (SNR) was characterized for varying exposure times, gains for different light intensities using a TV-Optoliner system. Software tools were developed to analyze ∼5000 images to extract different beam parameters. Quenching correction-factors were established by comparing scintillation Bragg-Peaks with water scanned ionization-chamber measurements. Quenching corrected Bragg-peaks were integrated to ascertain proton-beam range (PBR), width of Spared-Out-Bragg-Peak (MOD) and distal.

Chronic Exposure to Fine Particles and Mortality: An Extended Follow-up of the Harvard Six Cities Study from 1974 to 2009

Science.gov (United States)

Laden, Francine; Dockery, Douglas; Schwartz, Joel

2012-01-01

Background: Epidemiologic studies have reported associations between fine particles (aerodynamic diameter ≤ 2.5 µm; PM2.5) and mortality. However, concerns have been raised regarding the sensitivity of the results to model specifications, lower exposures, and averaging time. Objective: We addressed these issues using 11 additional years of follow-up of the Harvard Six Cities study, incorporating recent lower exposures. Methods: We replicated the previously applied Cox regression, and examined different time lags, the shape of the concentration–response relationship using penalized splines, and changes in the slope of the relation over time. We then conducted Poisson survival analysis with time-varying effects for smoking, sex, and education. Results: Since 2001, average PM2.5 levels, for all six cities, were < 18 µg/m3. Each increase in PM2.5 (10 µg/m3) was associated with an adjusted increased risk of all-cause mortality (PM2.5 average on previous year) of 14% [95% confidence interval (CI): 7, 22], and with 26% (95% CI: 14, 40) and 37% (95% CI: 7, 75) increases in cardiovascular and lung-cancer mortality (PM2.5 average of three previous years), respectively. The concentration–response relationship was linear down to PM2.5 concentrations of 8 µg/m3. Mortality rate ratios for PM2.5 fluctuated over time, but without clear trends despite a substantial drop in the sulfate fraction. Poisson models produced similar results. Conclusions: These results suggest that further public policy efforts that reduce fine particulate matter air pollution are likely to have continuing public health benefits. PMID:22456598

Progress report, 1980

International Nuclear Information System (INIS)

1980-01-01

The operation and development of facilities in the Foster Radiation Laboratory and the research carried out from November 1979 to October 1980 are summarized. The upgrading process for the synchrocyclotron is continuing. The main research activities are the studies of nuclear properties far from beta stability, complex nuclear reactions, the nuclear fission mechanism, and positron emission tomography. A mini-cyclotron is being installed at the Montreal Neurological Institute. Lists of personnel and publications are included

Production of high specific activity 123I for protein iodination for medical use

International Nuclear Information System (INIS)

Legoux, Y.; Cieur, M.; Crouzel, C.; Syrota, A.

1985-01-01

Iodine-123 is produced via xenon-133 by irradiation of a sodium iodide target with 108 MeV deuterons from the synchrocyclotron of IPN. The on-line production method is described. The specific activity of the iodine is determined by neutron activation analysis and by a radioimmunological method. The conditions labelling different proteins (insulin, angiotensin) are given and also the purification method to obtain a product ready for injection to patients. (author)

Generation of physician-scientists manpower: a follow-up study of the first 294 graduates of the Harvard-MIT Program of Health Sciences and Technology.

Science.gov (United States)

Abelmann, W H; Nave, B D; Wilkerson, L

1997-06-01

The MD program of the Harvard-MIT Division of Health Sciences and Technology was founded in 1970. One of its goals was the application of the academic resources of the two universities to the education of leaders in academic medicine and biomedical sciences. The first MD class was admitted in 1971. Prerequisites for admission are a strong background in quantitative sciences and demonstrated interest in research. Research and a thesis are obligatory. Enrollment in a PhD program is elective. Questionnaires were sent to 293 alumni who graduated from the MD program between 1975 and 1988, followed up by letters and telephone calls. By 1988, 296 students had graduated, 207 with an MD only, 89 with MD-PhD degrees. Follow-up by questionnaires of 293 living graduates (92%), plus indirect data on 11 others, revealed that 212 (75%) held faculty appointments in 64 medical schools. Overall, 73.5% of respondents were engaged in research: 68% of MDs and 86% of MD-PhDs. One hundred and four (38%) respondents spent more than 50% of their time on research: 54 (29%) of MDs and 50 (60%) of MD-PhDs. Seventy-five percent of respondents were active in teaching. Our experience indicates that both an MD-PhD program and a research-oriented MD program are effective in producing physician-scientists and leaders in academic medicine.

The CERN Synchro-Cyclotron Improvement Programme (SCIP) and its managerial problems

CERN Document Server

Lustig, H D

1976-01-01

This project proved that for large-scale projects comprising more than one thousand activities and involving the participation of several divisions and companies, the application of network planning techniques is essential, but that for some purposes the additional use of bar chart planning techniques is very helpful. Since the use of network planning is still not yet as widely spread as one would hope, special attention has to be paid to these questions before orders are placed and a close planning collaboration between manufacturer and client is required. For this the use of computer program for the evaluation of time-tables and for the supervision of information-flow can be of great help. (3 refs).

Measurement of neutron-induced fission cross-sections of Th232, U238, U233 and Np237 relative to U235 from 1 MeV to 200 MeV

Energy Technology Data Exchange (ETDEWEB)

Shcherbakov, O.A.; Laptev, A.B.; Petrov, G.A. [Petersburg Nuclear Physics Inst., Gatchina, Leningrad district (Russian Federation); Fomichev, A.V.; Donets, A.Y.; Osetrov, O.I.

1998-11-01

The measurements of neutron-induced cross-section ratios for Th232, U238, U233 and Np237 relative to U235 have been carried out in the energy range from 1 MeV up to 200 MeV using the neutron time-of-flight spectrometer GNEIS based on 1 GeV proton synchrocyclotron. Below 20 MeV, the results of present measurements are roughly in agreement with evaluated data though there are some discrepances to be resolved. (author)

Coherent pion production with the 910 MeV 3He beam at the CERN S.C

International Nuclear Information System (INIS)

Aslanides, E.

1979-01-01

The first experiment carried out at the CERN synchrocyclotron, 3 He + nucleus → X + π - , is analysed. The inclusive pion spectrum is given up to the kinematic limit covering cross sections from a few μb/sr MeV/C to 0.1 pb/sr MeV/C. An attempt is made to see how far these results are consistent with an interpretation based on the NN→NNπ process by means of nuclear form factors and by scaling [fr

Experiment list: SRX150451 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available is=Leukemia Chronic Myelogenous 39880346,54.9,7.2,2209 GSM935371: Harvard ChipSeq K562 SIRT6 std source_name...=K562 || biomaterial_provider=ATCC || lab=Harvard || lab description=Struhl - Harvard University || datatype

Experiment list: SRX150472 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available is=Leukemia Chronic Myelogenous 38544300,59.2,11.1,1031 GSM935392: Harvard ChipSeq K562 NELFe std source_nam...e=K562 || biomaterial_provider=ATCC || lab=Harvard || lab description=Struhl - Harvard University || datatyp

Experiment list: SRX150623 [Chip-atlas[Archive

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Experiment list: SRX150471 [Chip-atlas[Archive

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Experiment list: SRX150423 [Chip-atlas[Archive

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Experiment list: SRX150474 [Chip-atlas[Archive

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Experiment list: SRX150452 [Chip-atlas[Archive

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Experiment list: SRX150674 [Chip-atlas[Archive

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Full Text Available s=Leukemia Chronic Myelogenous 18469470,89.4,7.1,725 GSM935595: Harvard ChipSeq K562 BRF1 std source_name=K5...62 || biomaterial_provider=ATCC || lab=Harvard || lab description=Struhl - Harvard University || datatype=Ch

Experiment list: SRX150569 [Chip-atlas[Archive

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Full Text Available s=Leukemia Chronic Myelogenous 51487836,63.2,7.7,861 GSM935490: Harvard ChipSeq K562 BRF2 std source_name=K5...62 || biomaterial_provider=ATCC || lab=Harvard || lab description=Struhl - Harvard University || datatype=Ch

Use of modified Harvard step test for the evaluation of exercise tolerance in patients with a functional single ventricle after total cavopulmonary connection

Directory of Open Access Journals (Sweden)

A. A. Tupikina

2016-01-01

Full Text Available According to the literature, nearly one-third of patients with congenital heart diseases have signs of heart failure. Objective: to assess the possibility and results of using a modified Harvard step test (MHST for the evaluation of exercise tolerance in children with a functional single ventricle. The investigation covered 110 healthy children aged 6 to 16 years and 29 patients aged 3 to 16 years with a functional single ventricle after total cavopulmonary connection with an extracardiac conduit a year after surgery and fenestration closure. MHST using a complete protocol was carried out in 44,8% of the patients. In the other examinees, the reason for stopping the test was premature muscle weakness and dyspnea. This could establish Functional Class (FC II heart failure in 55,2% of the sick children. In the examinees, the MHST index (MHSTI characterizing exercise tolerance ranged from 22,4 to 111. The median MHSTI scores significantly differed between the groups of patients with FC I and II heart failure (p=0,021. Exercise tolerance was lower in 17,2% of the patients with a functional single ventricle; in the others it was average and above average (41,5 and 41,3%, respectively, which was suggestive of good hemodynamic adaptation in patients after surgery. The findings prove the safety and efficiency of using the above test in the evaluation of exercise tolerance in children 3 years of age and older.

Experiment list: SRX150720 [Chip-atlas[Archive

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Full Text Available sue Diagnosis=Fibrocystic Disease 71490650,87.2,15.5,1356 GSM935641: Harvard ChipSeq MCF10A-Er-Src Input std... source_name=MCF10A-Er-Src || biomaterial_provider=Struhl laboratory || lab=Harvard || lab description=Struhl - Harvard

Experiment list: SRX150587 [Chip-atlas[Archive

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Full Text Available is=Adenocarcinoma 32859626,93.1,16.6,6448 GSM935508: Harvard ChipSeq HeLa-S3 NF-YA IgG-rab source_name=HeLa-...S3 || biomaterial_provider=ATCC || lab=Harvard || lab description=Struhl - Harvard University || datatype=Ch

Experiment list: SRX150568 [Chip-atlas[Archive

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Full Text Available is=Adenocarcinoma 59265240,72.4,16.4,4779 GSM935489: Harvard ChipSeq HeLa-S3 RPC155 std source_name=HeLa-S3 ...|| biomaterial_provider=ATCC || lab=Harvard || lab description=Struhl - Harvard University || datatype=ChipS

Experiment list: SRX150661 [Chip-atlas[Archive

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Full Text Available is=Adenocarcinoma 59396606,71.7,11.1,1200 GSM935582: Harvard ChipSeq HeLa-S3 BRF1 std source_name=HeLa-S3 ||... biomaterial_provider=ATCC || lab=Harvard || lab description=Struhl - Harvard University || datatype=ChipSeq

Experiment list: SRX150495 [Chip-atlas[Archive

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Full Text Available is=Adenocarcinoma 62508352,67.6,8.4,1556 GSM935416: Harvard ChipSeq HeLa-S3 ZZZ3 std source_name=HeLa-S3 || ...biomaterial_provider=ATCC || lab=Harvard || lab description=Struhl - Harvard University || datatype=ChipSeq

Experiment list: SRX150565 [Chip-atlas[Archive

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Full Text Available =Adenocarcinoma 54953593,74.3,12.2,1703 GSM935486: Harvard ChipSeq HeLa-S3 BDP1 std source_name=HeLa-S3 || b...iomaterial_provider=ATCC || lab=Harvard || lab description=Struhl - Harvard University || datatype=ChipSeq |

Fine particulate air pollution and all-cause mortality within the Harvard Six-Cities Study: variations in risk by period of exposure.

Science.gov (United States)

Villeneuve, Paul J; Goldberg, Mark S; Krewski, Daniel; Burnett, Richard T; Chen, Yue

2002-11-01

We used Poisson regression methods to examine the relation between temporal changes in the levels of fine particulate air pollution (PM(2.5)) and the risk of mortality among participants of the Harvard Six Cities longitudinal study. Our analyses were based on 1430 deaths that occurred between 1974 and 1991 in a cohort that accumulated 105,714 person-years of follow-up. For each city, indices of PM(2.5) were derived using daily samples. Individual level data were collected on several risk factors including: smoking, education, body mass index (BMI), and occupational exposure to dusts. Time-dependent indices of PM(2.5) were created across 13 calendar periods (/= 1990) to explore whether recent or chronic exposures were more important predictors of mortality. The relative risk (RR) of mortality calculated using Poisson regression based on average city-specific exposures that remained constant during follow-up was 1.31 [95% confidence interval (CI) = 1.12-1.52] per 18.6 microg/m(3) of PM(2.5). This result was similar to the risk calculated using the Cox model (RR = 1.26, 95% CI = 1.08-1.46). The RR of mortality was attenuated when the Poisson regression model included a time-dependent estimate of exposure (RR = 1.19, 95% CI = 1.04-1.36). There was little variation in RR across time-dependent indices of PM(2.5). The attenuated risk of mortality that was observed with a time-dependent index of PM(2.5) is due to the combined influence of city-specific variations in mortality rates and decreasing levels of air pollution that occurred during follow-up. The RR of mortality associated with PM(2.5) did not depend on when exposure occurred in relation to death, possibly because of little variation between the time-dependent city-specific exposure indices.

NASA FACILITY FOR THE STUDY OF SPACE RADIATION EFFECTS

Energy Technology Data Exchange (ETDEWEB)

Johnson, David R.

1963-04-15

Information on the energies andd fluxes of trapped electrons and protons in space is summarized, and the Space Radiation Effects Laboratory being constructed to simulate most of the space particulate-energy spectrum is described. A 600-Mev proton synchrocyclotron of variable energy and electron accelerators of 1 to 10 Mev will be included. The accelerator characteristics and the arrangement of the experimental and support buildings, particularly the beam facilities, are discussed; and the planned activities of the laboratory are given. (D.C.W.)

Hydrostatic control system for the height position of the JINR synchrotron

International Nuclear Information System (INIS)

Vasyutinskij, I.Yu.; Zinov'ev, L.P.; Karpov, I.I.

1978-01-01

Hydrostatic system with remote read-out is created for a more operative control of height position of synchrocyclotrone electromagnet. 3 hydrostatic heads with electrocontact registration of liquid level position were mounted on every electromagnet quadrant. The heads are placed under the magnet in centers of survey channel of the foundation and are switched on in series. Teh schemes of the main system units are given. The order of assembling and adjustment of hydrostatic system elements of the accelerator is described

Harvard Business School energy report. Energie-Report der Harvard Business School

Energy Technology Data Exchange (ETDEWEB)

Stobaugh, R; Yergin, D

1979-01-01

With the help of cost-benefit calculations which include also the - to a great extent - neglected external social costs, the team of authors of the Havard Businees School conclude that energy conservation as well as alternative energies such as solar energy are the most important energy sources of the future. This conclusion clearly contradicts the present prevailing opinion which says the expansion of energy consumption and the improvement of power supply by nuclear power plants are indispensable for the securing of economic growth and the economic structure. Although the authors keep up an option for nuclear energy (as it may perhaps be possible to solve the problem of radioactive waste disposal) they put forward the sober statement that - last not least because of its questionable economic efficiency - nuclear power cannot be a solution to energy crisis for the rest of the century, let alone to the politically precarious dependence of the Western Countries on the Saudi-Arabic import oil. The Havard Analysis is based on the latest numerical data and it is not only valid for the USA. It shall have even more impact for a country like the Federal Republic of Germany which is short of raw material. Therefore the American figures are put in relation to the German situation in an additional chapter.

Innovative curriculum for second-year Harvard-MIT medical students: practicing communication skills with volunteer patients giving immediate feedback

Directory of Open Access Journals (Sweden)

Ali NB

2017-05-01

Full Text Available Nadaa B Ali,1 Stephen R Pelletier,2 Helen M Shields1 1Department of Medicine, Brigham and Women’s Hospital, 2Center for Evaluation, Harvard Medical School, Boston, MA, USA Purpose: Medical students are expected to develop excellent communication skills. The purpose of our study was to create an innovative communication skills exercise using real volunteer patients and physician co-teachers for students to practice communication skills while receiving immediate feedback.Method: This is a mixed methods study where second-year medical students participated in the communication skills exercise with real patients and physician co-teachers giving immediate feedback. Clinical scenarios reflected the patients’ actual experiences. Students acted out roles as physicians. Physicians co-taught with the patients and gave immediate feedback to students. Students completed an anonymous written survey at the end of the exercise. Qualitative and quantitative responses were recorded. Student feedback from the 2014 surveys was used to modify the teaching designs to increase active role play opportunities by having only two students in each group and doubling the number of stations with real patients.Results: Students rated the overall exercise and the utility of patient volunteers in learning how to communicate on a Likert scale of 1–5, where in this medical school traditionally 1 is excellent and 5 is poor. In 2014, the exercises were rated with a mean score of 1.47 (SD 0.621. In 2015, the exercises were rated with a mean score of 1.03 (SD 0.62. In 2016, the exercises were rated with a mean score of 1.27 (SD 0.52. ANOVA analysis (p=0.002 and Bonferroni corrections indicate a statistically significant difference between combined mean scores of the exercise in 2014 and 2015 (p=0.001. No difference was shown between 2014 and 2016 or 2015 and 2016.Conclusions: Medical students rated practicing communication skills with real patient volunteers and physician co

Experiment list: SRX150586 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available -Barr Virus 33195472,90.4,25.9,15633 GSM935507: Harvard ChipSeq GM12878 NF-YB IgG-mus source_name=GM12878 ||...?PgId=165&q=GM12878 || lab=Harvard || lab description=Struhl - Harvard University || datatype=ChipSeq || dat

Experiment list: SRX150496 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ein-Barr Virus 63040797,85.0,19.7,1435 GSM935417: Harvard ChipSeq GM12878 SPT20 std source_name=GM12878 || b...gId=165&q=GM12878 || lab=Harvard || lab description=Struhl - Harvard University || datatype=ChipSeq || datat

Experiment list: SRX150585 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available -Barr Virus 32926476,94.0,12.0,2668 GSM935506: Harvard ChipSeq GM12878 NF-YA IgG-mus source_name=GM12878 || ...PgId=165&q=GM12878 || lab=Harvard || lab description=Struhl - Harvard University || datatype=ChipSeq || data

Nocera, Prof. Daniel G

Indian Academy of Sciences (India)

Fellow Profile. Elected: 2013 Honorary. Nocera, Prof. Daniel G. Date of birth: 1957. Address: Dept. of Chemistry & Chem. Biol., Harvard University, 12, Oxford Street, Cambridge, MA 02138, USA Contact: Office: (+1-617) 495 8904. Email: dnocera@fas.harvard.edu. http://chemistry.harvard.edu/people/daniel-g-nocera.

Experiment list: SRX150670 [Chip-atlas[Archive

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Full Text Available gnosis=Fibrocystic Disease 53773968,83.9,44.3,13035 GSM935591: Harvard ChipSeq MCF10A-Er-Src EtOH 0.01pct ST...AT3 std source_name=MCF10A-Er-Src || biomaterial_provider=Struhl laboratory || lab=Harvard || lab description=Struhl - Harvard

Experiment list: SRX150630 [Chip-atlas[Archive

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Full Text Available gnosis=Fibrocystic Disease 42446970,82.6,25.1,47688 GSM935551: Harvard ChipSeq MCF10A-Er-Src EtOH 0.01pct 12...hr STAT3 std source_name=MCF10A-Er-Src || biomaterial_provider=Struhl laboratory || lab=Harvard || lab description=Struhl - Harvard

2015 Soft Condensed Matter Physics: Self-Assembly and Active Matter GRC/GRS

Science.gov (United States)

2015-10-20

Broad Institute of MIT and Harvard Poster Presenter Registered Beller, Daniel A Harvard University Poster Presenter Registered Bi, Dapeng Syracuse...Poster Presenter Registered Deforet, Maxime Memorial Sloan Kettering Cancer Center Poster Presenter Registered Del Gado, Emanuela Georgetown...Registered Dullens, Roel University of Oxford Poster Presenter Registered Fakhri, Nikta MIT Poster Presenter Registered Fan, Jing Harvard

Experiment list: SRX150629 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available sue Diagnosis=Fibrocystic Disease 27949151,89.1,5.9,589 GSM935550: Harvard ChipSeq MCF10A-Er-Src EtOH 0.01pc...t 12hr Input std source_name=MCF10A-Er-Src || biomaterial_provider=Struhl laboratory || lab=Harvard || lab description=Struhl - Harva...rd University || datatype=ChipSeq || datatype descriptio

Experiment list: SRX150667 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available t|Tissue Diagnosis=Fibrocystic Disease 69172664,86.5,35.3,28780 GSM935588: Harvard ChipSeq MCF10A-Er-Src EtO...H 0.01pct Pol2 std source_name=MCF10A-Er-Src || biomaterial_provider=Struhl laboratory || lab=Harvard || lab description=Struhl - Har...vard University || datatype=ChipSeq || datatype descript

Experiment list: SRX150535 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available t|Tissue Diagnosis=Fibrocystic Disease 69171580,86.8,43.7,20874 GSM935456: Harvard ChipSeq MCF10A-Er-Src 4OH...TAM 1uM 36hr Pol2 std source_name=MCF10A-Er-Src || biomaterial_provider=Struhl laboratory || lab=Harvard || ...lab description=Struhl - Harvard University || datatype=ChipSeq || datatype descr

Acta Structilia: Submissions

African Journals Online (AJOL)

After that use a) etc. 11. Source references in the text must be in the Harvard style of referencing (Author, date: pages). i. e. (Schleien, 2006: 20-40). 12. Foot- and endnotes are likewise done in the Harvard style of referencing. 13. The references list (Harvard style of referencing) should contain all the relevant information, ...

Experimental verification of the relativistic fine-structure term of the Klein-Gordon equation in pionic titanium atoms

International Nuclear Information System (INIS)

Delker, L.; Dugan, G.; Wu, C.S.; Lu, D.C.; Caffrey, A.J.; Cheng, Y.T.; Lee, Y.K.

1979-01-01

A newly designed, large-aperture and high-resolution bent-crystal spectrometer has been used to observe high-intensity sources of pionic x rays. The pionic x-ray source was a target of natural titanium which was placed adjacent to a copper pion-production target in the external beam of the Nevis synchrocyclotron. The energy difference between the 5g → 4f and 5f → 4d transitions in pionic titanium was measured to be 87.6 +- 1.8 eV. Comparison with the prediction of the Klein-Gordon equation is made

Some aspects of radiation protection near high-energy proton accelerators

CERN Document Server

Tuyn, Jan Willem Nicolaas

1977-01-01

The CERN site near Geneva borders Satigny and Meyrin in Switzerland and Saint-Genis-Pouilly and Prevention in France. The 600 MeV proton synchrocyclotron (SC) has been in operation since 1957, the 28 GeV proton synchrotron (PS) since 1960, and the Intersecting Storage Rings (ISR) since 1971. A fourth large accelerator, the 400 GeV super proton synchrotron (SPS), will soon be in service. The internal and external radiation protection problems caused by these machines, together with the solutions, are reviewed in the light of experience. (5 refs).

Scaling gross ecosystem production at Harvard Forest with remote sensing: a comparison of estimates from a constrained quantum-use efficiency model and eddy correlation

International Nuclear Information System (INIS)

Waring, R.H.; Law, B.E.; Goulden, M.L.; Bassow, S.L.; McCreight, R.W.; Wofsy, S.C.; Bazzaz, F.A.

1995-01-01

Two independent methods of estimating gross ecosystem production (GEP) were compared over a period of 2 years at monthly integrals for a mixed forest of conifers and deciduous hardwoods at Harvard Forest in central Massachusetts. Continuous eddy flux measurements of net ecosystem exchange (NEE) provided one estimate of GEP by taking day to night temperature differences into account to estimate autotrophic and heterotrophic respiration. GEP was also estimated with a quantum efficiency model based on measurements of maximum quantum efficiency (Qmax), seasonal variation in canopy phenology and chlorophyll content, incident PAR, and the constraints of freezing temperatures and vapour pressure deficits on stomatal conductance. Quantum efficiency model estimates of GEP and those derived from eddy flux measurements compared well at monthly integrals over two consecutive years (R 2 = 0–98). Remotely sensed data were acquired seasonally with an ultralight aircraft to provide a means of scaling the leaf area and leaf pigmentation changes that affected the light absorption of photosynthetically active radiation to larger areas. A linear correlation between chlorophyll concentrations in the upper canopy leaves of four hardwood species and their quantum efficiencies (R 2 = 0–99) suggested that seasonal changes in quantum efficiency for the entire canopy can be quantified with remotely sensed indices of chlorophyll. Analysis of video data collected from the ultralight aircraft indicated that the fraction of conifer cover varied from < 7% near the instrument tower to about 25% for a larger sized area. At 25% conifer cover, the quantum efficiency model predicted an increase in the estimate of annual GEP of < 5% because unfavourable environmental conditions limited conifer photosynthesis in much of the non-growing season when hardwoods lacked leaves

Transcriptional and Chromatin Dynamics of Muscle Regeneration After Severe Trauma

Science.gov (United States)

2016-10-12

02127. 2Broad Institute of MIT and Harvard, Cambridge , MA 02142, Harvard Stem Cell Institute, Cambridge , MA 02138, Dept. of Stem Cell and...Regenerative Biology, Harvard University, Cambridge , MA 02138. 3United States Army Institute of Environmental Medicine - Military Performance Division, Natick...throughout the regenerative process in a mouse model of traumatic muscle injury. We first illustrate how the transcriptional landscape of coding and

Venezuela’s Corruption On the Rise: Fourteen Years of Chavismo

Science.gov (United States)

2016-09-01

Venezuela’s abundance of oil has led to a history of failed economic models used to attempt to temper the Resource Curse. Javier Corrales from Harvard ...the 1990s and beyond,” ReVista Harvard Review of Latin America, no. Fall (1999), accessed March 11, 2016, http://revista.drclas.harvard.edu/ book ...incorporate a three-prong anti-corruption approach, including political, economic , and social accountability reforms with market-friendly social democratic

Zatlers addresses Harvard audience

Index Scriptorium Estoniae

2010-01-01

Läti presidendi Valdis Zatlersi Harvardi ülikoolis peetud kõnest, milles ta märgib, et üks tema jaoks tähtsamatest küsimustest on, kes võiks Läti uue peaministrina riigi praegust majanduskurssi jätkata, ja leiab, et Läti kuulub oma rahvaarvu arvestades Afganistani enam panustavate riikide hulka

Modelling the impact of soil Carbonic Anhydrase on the net ecosystem exchange of OCS at Harvard forest using the MuSICA model

Science.gov (United States)

Launois, Thomas; Ogée, Jérôme; Commane, Roisin; Wehr, Rchard; Meredith, Laura; Munger, Bill; Nelson, David; Saleska, Scott; Wofsy, Steve; Zahniser, Mark; Wingate, Lisa

2016-04-01

The exchange of CO2 between the terrestrial biosphere and the atmosphere is driven by photosynthetic uptake and respiratory loss, two fluxes currently estimated with considerable uncertainty at large scales. Model predictions indicate that these biosphere fluxes will be modified in the future as CO2 concentrations and temperatures increase; however, it still unclear to what extent. To address this challenge there is a need for better constraints on land surface model parameterisations. Additional atmospheric tracers of large-scale CO2 fluxes have been identified as potential candidates for this task. In particular carbonyl sulphide (OCS) has been proposed as a complementary tracer of gross photosynthesis over land, since OCS uptake by plants is dominated by carbonic anhydrase (CA) activity, an enzyme abundant in leaves that catalyses CO2 hydration during photosynthesis. However, although the mass budget at the ecosystem is dominated by the flux of OCS into leaves, some OCS is also exchanged between the atmosphere and the soil and this component of the budget requires constraining. In this study, we adapted the process-based isotope-enabled model MuSICA (Multi-layer Simulator of the Interactions between a vegetation Canopy and the Atmosphere) to include the transport, reaction, diffusion and production of OCS within a forested ecosystem. This model was combined with 3 years (2011-2013) of in situ measurements of OCS atmospheric concentration profiles and fluxes at the Harvard Forest (Massachussets, USA) to test hypotheses on the mechanisms responsible for CA-driven uptake by leaves and soils as well as possible OCS emissions during litter decomposition. Model simulations over the three years captured well the impact of diurnally and seasonally varying environmental conditions on the net ecosystem OCS flux. A sensitivity analysis on soil CA activity and soil OCS emission rates was also performed to quantify their impact on the vertical profiles of OCS inside the

What Factors Underlie Vertical and Horizontal Export Diversification

African Journals Online (AJOL)

Ritsumeikan Asia Pacific University

progress in initiating process of economic and social development. .... Source: UNCTAD Hand Book of Statistics, UNCTAD database. Though many ...... Development and Harvard Institute for International Development: Harvard University,.

Pion radiation therapy

International Nuclear Information System (INIS)

Kligerman, M.M.

1975-01-01

Results are summarized from studies on the relative biological effects as compared with x or γ radiation and OER of negative pi mesons produced by the Berkeley 184-inch synchrocyclotron or the NIMROD 7-GeV proton synchrocyclotron at the Rutherford High Energy Laboratory in England using cultured animal cells or Vicia faba cells as the test system. Preliminary results are reported from similar radiobiological studies at the Los Alamos Meson Physics Facility. The relative response of human tissues to peak pion irradiation was compared with 140 kV x rays in a single patient with multiple malignant melanoma by observing the acute response of the skin surrounding metastatic modules following exposure to either pions or x radiation. Color photographs of the irradiated areas made at least twice weekly and densitometry measurements and observations by radiation therapists indicated that maximum erythemia occurred during the fifth, sixth, or seventh week after the start of a schedule of fractionated exposure to 15 fractions over 19 elapsed days. X irradiation was delivered at a dose rate of 500 rads/min to modules to deliver 55, 66, or 75 percent of a skin surface dose of 5,200 rads and pion irradiation, at doses numerically 50 percent of the x ray dose, was delivered at a dose rate of 5 to 7 rads/min. Dose response curves were plotted. Results of histological examinations of skin samples taken 24 weeks following irradiation are reported. Results are discussed relative to the destruction of melanoma cells following pion or x ray treatment

77 FR 57086 - Open Internet Advisory Committee

Science.gov (United States)

2012-09-17

... Student Center, Harvard Law School, 1585 Massachusetts Avenue, Cambridge, MA 02138. FOR FURTHER... be broadcast live with open captioning over the Internet at http://cyber.law.harvard.edu/events/2012...

Progress report, 1979

International Nuclear Information System (INIS)

During 1979 the synchrocyclotron 3 He and alpha beam intensities have been improved and a stochastic beam stretcher for alpha and deuteron beams has been installed. The PDP-11 memory has been enlarged and a terminal for the PDP-15 installed at the cyclotron control desk. The angular correlation facility for on-line γ-spectrographic studies has been completed, and a microprocessor-controlled tape transport system integrated into the helium jet transport facilities. The main research interests continued to be the properties of nuclei far from beta stability, complex nuclear reactions, the fission mechanism, and positron tomography. (LL)

Annual report 1976

International Nuclear Information System (INIS)

Lindh, U.; Sundberg, O.

1977-01-01

The Gustaf Werner Institute (GWI) annual report for the year 1976 presents in a condensed form the scientific activities in the disciplines High Energy Physics and Physical Biology at Uppsala University. The activities in High Energy Physics fall into three domains: Research with the local accelerator, participation in collaborations at international centers and work on the rebuilding of the Uppsala synchrocyclotron. A major subject of research in Physical Biology is control of growth and differentiation, as reflected in the kinetics of biochemical reactions or in the behaviour of healthy or malignant cells at various levels of organization. (Auth.)

p- and n-induced U-fission tracks as possible error sources in the fission track dating of extraterrestric samples

International Nuclear Information System (INIS)

Thiel, K.

1975-01-01

Using the fission track dating method by means of uranium fission tracks in meteorites and moon samples (according to the successful Apollo and Luna missions), special problems arise, as the samples frequently have a very great age and were subjected to the inmediate effect of primary cosmic radiation. To determine the share of induced fission tracks, an extended 'cosmic ray' simulation experiment was carried out on the p-synchrocyclotron in CERN, Geneva; the performance and results of the test with the proton flux and U fission track measurements are dealt with in detail. (HK/LH) [de

Charged particle cross-section data and their systematization

International Nuclear Information System (INIS)

Nassif, S.

1982-07-01

The reaction cross-sections and the thick target yields of (α,αxn) and (α,xn), induced by the alpha particles from the Buenos Aires 60 inch synchrocyclotron for Cu, Y, Zr, Rh, Te, Ta, Au and Pb were obtained. The ''stocked foil'' method was applied. The ''nuclear spin density'' parameter was determined using a phenomenological approximation from the cross section data for 181 Ta(α,n) reaction producing isomeric pairs of sup(184m)Re and sup(184g)Re. The systematic behaviour of the present result and the results of other authors were demonstrated

Progress report, 1975

International Nuclear Information System (INIS)

The properties of the exotic nuclides lying off the valley of beta stability are under study and new nuclides continue to be identified. A new ion source for the on-line mass spectrometer for isotope separation allows the investigation of neutron deficient and neutron rich nuclei. A superconducting beta ray spectrometer has been used to study nuclear mass in high energy nuclear beta decay. The Proton Synchrocyclotron is being upgraded to allow acceleration of particles like d, 3 He ++ , and 4 He ++ , to improve proton beam intensity, and to improve the cyclotron operating stability and vacuum system. (E.C.B.)

Spinal muscular atrophy type I and the dual role of viruses: An interview with Professor Basil T. Darras, Professor of Neurology (Pediatrics) at Harvard Medical School.

Science.gov (United States)

Mammas, Ioannis N; Spandidos, Demetrios A

2018-04-01

According to Professor Basil T. Darras, Professor of Neurology (Pediatrics) at Harvard Medical School and Director of the Spinal Muscular Atrophy (SMA) Program at Boston Children's Hospital in Boston (MA, USA), the diagnosis of SMA type I is clinical and is based on detailed general physical and neurological examinations. SMA type I remains the most common genetic disease resulting in death in infancy and is really devastating for the child, the parents, as well as the medical professionals with the privilege of caring for patients with SMA and their parents. The proposed management options include: i) no respiratory support; ii) non-invasive ventilation; and iii) tracheotomy with mechanical ventilation. Deciding, which option is the best, is indeed a very personal decision. The optimal clinical care should be extremely mindful of parents' wishes and management goals with regard to the quality of life. Since the end of 2016 in the USA, and recently in Europe, there exists the possibility of accessing a novel treatment drug for SMA, namely Nusinersen. This antisense oligonucleotide is administered intrathecally and increases the production of the fully functional SMN protein, thus improving motor function, the quality of life and survival. Among the ongoing clinical trials, oral treatment with RG7916, a small molecule SMN2 splicing modifier, appears to be really promising. Gene therapy using viral vectors is expected to offer an 'one and done' therapy and possibly a cure, if administered early in life, before any symptoms appear. It is really interesting that viruses, which at the moment are the cause of death of children with SMA, if genetically modified, may be used for their treatment.

Combined proton and photon irradiation for craniopharyngioma: Long-term results of the early cohort of patients treated at Harvard Cyclotron Laboratory and Massachusetts General Hospital

International Nuclear Information System (INIS)

Fitzek, Markus M.; Linggood, Rita M.; Adams, Judy; Munzenrider, John E.

2006-01-01

Purpose: We report the results of the early cohort of patients treated for craniopharyngioma with combined proton-photon irradiation at the Massachusetts General Hospital and the Harvard Cyclotron Laboratory. Methods and Materials: Between 1981 and 1988, 15 patients with craniopharyngioma were treated in part or entirely with fractionated 160 MeV proton beam therapy. The group consisted of 5 children (median age, 15.9 years) and 10 adults (median age, 36.2 years). Median dose prescribed to the tumor was 56.9 cobalt Gray equivalent (CGE; 1 proton Gray = 1.1 CGE). The median proton component was 26.9 CGE. Patients were treated after documented recurrence after initial surgery (n = 6) or after subtotal resection or biopsy (n = 9). None had had prior radiation therapy. Results: Median observation period of surviving patients (n = 11) was 13.1 years from radiotherapy. One patient was lost to follow-up with tumor control after 5.2 years. Actuarial 10-year survival rate was 72%. Four patients have died 5-9.1 years after treatment, two from local failure. Actuarial 5- and 10-year local control rates were 93% and 85%, respectively. The functional status of the living adult patients is unaltered from their preradiotherapy status; all of them continued leading normal or near normal working lives. None of the patients treated as a child had experienced recurrence of tumor. One child shows learning difficulties and slight retardation, comparable to his preradiotherapy status. The others have professional achievements within the normal range. Conclusion: Results in terms of survival and local control are comparable with other contemporary series. Although no formal neuropsychological testing was performed, the surrogate measures of lifestyle and professional accomplishments appear to be satisfactory

Think Piece: Pioneers as Relational Subjects? Probing Relationality ...

African Journals Online (AJOL)

therefore offers a possible framework for more detailed empirical studies on relationality in collective learning .... pioneers. This idea is also reflected in a book co-authored by Hermansen called Commonities ..... studies. Harvard MS: Harvard.

Design: More than a cool chair

DEFF Research Database (Denmark)

Friis, Silje Alberthe Kamille; Austin, Robert; Sullivan, Erin

2006-01-01

Austin, R., Friis, K., Sullivan, E. 2006. Design: More than a cool chair. Boston: Harvard Business School Publishing.......Austin, R., Friis, K., Sullivan, E. 2006. Design: More than a cool chair. Boston: Harvard Business School Publishing....

Timothy Leary, Richard Alpert (Ram Dass) and the changing definition of psilocybin.

Science.gov (United States)

Wark, Colin; Galliher, John F

2010-05-01

This research focuses on the events leading to the 1968 U.S. federal prohibition of psilocybin. It is a study of duelling moral entrepreneurs-Timothy Leary and Richard Alpert vs. the Harvard University Administration. The goal is to show how the primary active compound in an ostensibly harmless fungus (the psilocybin mushroom) became controversial in less than a decade. We used books, newspapers, magazine articles and previously unpublished materials (including documents from the Harvard Archives) to analyze Leary and Alpert's lives and careers through the early 1970s. The prohibition of psilocybin in the U.S. was largely a product of Leary and Alpert's involvement in the "Harvard drug scandal" and their transformation from Harvard professors to countercultural icons. They tested the substance on a variety of human subjects and in doing so piqued the interest of Harvard undergraduates while drawing condemnation from other faculty and Harvard administrators. This case is theoretically interesting because unlike most illegal drugs, psilocybin was never linked to a threatening minority group, but to some of the nation's most privileged youth. The Harvard administrators were not really moral entrepreneurs but Leary and Alpert clearly were. Although they were far from being prohibitionists, they were self-righteous crusaders on different but equally holy missions for the good of young and minority Americans. Ironically, due to their successes the possession of psilocybin was criminalized under United States federal law in 1968 (Pub. L. No. 90-639, Stat. 1361 1968 and Boire, 2002). This case study demonstrates that crusaders can be successful in changing culture even when laws are passed in futile attempts to control their behaviour, just as Leary predicted. Copyright 2009 Elsevier B.V. All rights reserved.

Stemcell Information: SKIP000183 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available m's F12 deficient Medium with 2mM L-glutamine ... Yes 46XY ... George Q Daley George Q Daley Harvard... Stem Cell Institute Harvard Stem Cell Institute ... Available NIGMS Coriell Cell Repository NIGMS Cor

Other Resources for Researchers

African Journals Online (AJOL)

The AfricaPortal is an online resource of policy research on African issues. ... Over 3000 Open Access books, journals and digital documents relating to African ... guides. http://www.lib.monash.edu.au/tutorials/citing/harvard.html Harvard Style.

IT-projekter er stadig risikable

DEFF Research Database (Denmark)

Harboe, Peter Georg

2011-01-01

Anmeldelse af Bent Flyvbjergs artikel i Harvard Business Review "Why your IT-projects may be riskier than you think"......Anmeldelse af Bent Flyvbjergs artikel i Harvard Business Review "Why your IT-projects may be riskier than you think"...

Implementing the 2009 Institute of Medicine recommendations on resident physician work hours, supervision, and safety

Directory of Open Access Journals (Sweden)

Blum AB

2011-06-01

Full Text Available Alexander B Blum1, Sandra Shea2, Charles A Czeisler3,4, Christopher P Landrigan3-5, Lucian Leape61Department of Health and Evidence Policy, Mount Sinai School of Medicine, New York, NY, USA; 2Committee of Interns and Residents, SEIU Healthcare Division, Service Employees International Union, New York, NY, USA; 3Harvard Work Hours, Health and Safety Group, Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA; 4Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; 5Division of General Pediatrics, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA; 6Department of Health Policy and Management, Harvard School of Public Health, Boston, MA, USAAbstract: Long working hours and sleep deprivation have been a facet of physician training in the US since the advent of the modern residency system. However, the scientific evidence linking fatigue with deficits in human performance, accidents and errors in industries from aeronautics to medicine, nuclear power, and transportation has mounted over the last 40 years. This evidence has also spawned regulations to help ensure public safety across safety-sensitive industries, with the notable exception of medicine.

Magnitude and predictors of excessive alcohol use in Ethiopia ...

African Journals Online (AJOL)

user

11Harvard T.H. Chan School of Public Health, Harvard University, E-mail: ST: solomon.teferra@gmail.com USA. Magnitude ..... cigarettes while drinking (34). ... Addiction. 2011;106(10):. 1718–24. 3. Alcohol an Obstacle to Development in East.

Challenges in the Study of Ancient Legal Influence

Directory of Open Access Journals (Sweden)

Nicholas H. D. Foster

2006-01-01

Full Text Available Review of: Gideon Libson, Jewish and Islamic Law. A Comparative Study of Custom during the Geonic Period (Islamic Legal Studies Program, Harvard Law School, Cambridge, MA: Harvard University Press 2003, xi, 367 p., ISBN 0-674-01106-6

Model of Dees and Rotco for the 600 MeV SC

CERN Multimedia

CERN PhotoLab

1978-01-01

The accelerating frequency of the 600 MeV Synchro-Cyclotron (SC) was modulated by the varying capacity of a rotating condenser ("Rotco", the most delicate component of the SC). A 1/5-scale model, dating from the design-period of the SC, was used to study improvements to the SC RF-system, and also the acceleration of ions, first Helium and, at the time of this picture, Carbon. In the middle of the picture is the case containing the Dees. To the left, at the wide end of the cone, a rotco. Reinhold Hohbach is busy with measurements. See also 7805235 (Annual Report 1978, p.110).

Particle unstable excited states in /sup 9/Be influence of beta recoil and width on delayed particle spectra

CERN Document Server

Nyman, G H; Jonson, B; Kratz, K L; Larsson, P O; Mattsson, S; Ziegert, W

1981-01-01

The light nucleus /sup 9/Be has been studied through the emission of beta-delayed neutrons and alpha particles from /sup 9/Li. The activity is produced at the ISOLDE facility in fragmentation reactions induced either by 600 MeV proton or 910 MeV /sup 3/He beams from the CERN Synchro-cyclotron. After mass separation neutron spectra are recorded using /sup 3/He-filled proportional counters, while surface barrier detectors are used for the spectroscopy of alpha particles. Effects on the spectrum shape induced by recoil and polarization phenomena as well as large widths of the intermediate states are discussed. (14 refs).

Experiments at CERN in 1977

International Nuclear Information System (INIS)

1977-08-01

This report catalogues approved experiments at CERN and has been compiled as a guide to the status of the experimental research programme at the 400 GeV Proton Synchrotron (SPS), the Intersecting Storage Rings (ISR), the 25 GeV Proton Synchrotron (PS) and the Synchro-Cyclotron (SC). The schematic layouts of beams and experiments at the various machines are given in the beginning of the report and are followed by descriptive material on the experiments. In general, a short summary of each of the approved experiments is given with a description of the physics purpose, the apparatus employed, a list of the participants and the name of the collaboration. (Auth.)

Experiments at CERN in 1979

International Nuclear Information System (INIS)

Anon.

1979-08-01

The 1979 catalogue of approved experiments at CERN has been compiled as a guide to the status of the experimental research programme at the 400 GeV Proton Synchrotron (SPS), the Intersecting Storage Rings (ISR), the 25 GeV Proton Synchrotron (PS), and the Synchrocyclotron (SC). The schematic layouts of beams and experiments at the various machines are given in the beginning of the report and are followed by descriptive material on the experiments. In general, a short summary of each of the approved experiments is given, with a description of the physics purpose, the apparatus employed, a list of the participants and the name of the collaboration. (Auth.)

Computer codes for beam dynamics analysis of cyclotronlike accelerators

Science.gov (United States)

Smirnov, V.

2017-12-01

Computer codes suitable for the study of beam dynamics in cyclotronlike (classical and isochronous cyclotrons, synchrocyclotrons, and fixed field alternating gradient) accelerators are reviewed. Computer modeling of cyclotron segments, such as the central zone, acceleration region, and extraction system is considered. The author does not claim to give a full and detailed description of the methods and algorithms used in the codes. Special attention is paid to the codes already proven and confirmed at the existing accelerating facilities. The description of the programs prepared in the worldwide known accelerator centers is provided. The basic features of the programs available to users and limitations of their applicability are described.

Contributions to a systematic examination of deformed transition nuclei by the study of the decay of 188Tl and 190Tl

International Nuclear Information System (INIS)

Waetzig, W.

1980-01-01

Using the reaction 197 Au( 3 He,xn) Tl the decay of the nuclides 188 Tl and 190 Tl to 188 Hg (Tsub(1/2) = 70s) respectively to 190 Hg(Tsub(1/2) = 3.0 min) was studied at the mass separator ISOCELE of the Orsay-synchrocyclotron by gamma, conversion electron, gamma-gamma coincidence, and electron-gamma coincidence spectroscopy. The level schemes of 188 Hg and 190 Hg could be remarkably extended in comparison with earlier works. By a statistical analysis of the nuclear level density the nuclear temperature was calculated as a measure for the number of excitation modes of these nuclei. (orig./HSI) [de

Sam Ting at the ISR intersection I-2 (experiment R209)

CERN Multimedia

CERN PhotoLab

1976-01-01

The Genova-Harvard-MIT-Pisa Collaboration, later CERN-Harvard-Frascati-MIT-Naples-Pisa Collaboration, set up an experiment to search for the electromagnetic properties of protons in the time-like region and search for the neutral boson Z0 (Muon pair production)

Stemcell Information: SKIP000181 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available Eagles Medium, 1:1 mixture with 2mM L-glutamine ... Yes 46,XX.arr(1-22,X)x2 ... George Q Daley George Q Daley Harvard... Stem Cell Institute Harvard Stem Cell Institute ... Available NIGMS Coriell Cell Rep

Kundetilpasset masseproduktion

DEFF Research Database (Denmark)

Bukh, Per Nikolaj

2010-01-01

Anmeldelse af Do you want to keep your customers forever, B. Joseph Pine II, Don Peppers & Martha Rogers, Harvard Business Press.......Anmeldelse af Do you want to keep your customers forever, B. Joseph Pine II, Don Peppers & Martha Rogers, Harvard Business Press....

Florence Jessie MacWilliams (1917-1990)

Indian Academy of Sciences (India)

Preeti Shankar

Johns Hopkins University, following him to Harvard University to study with him for a year. There was a ... was a student in Harvard at the same time. ... neers. It was one of the major works responsible for laying the foundation for a revolution.

List of Institutes who have agreed to send material on loan to contributors of Flora Malesiana

NARCIS (Netherlands)

NN,

1947-01-01

The Arnold Arboretum of Harvard University, Jamaica Plain, Mass. The Gray Herbarium of Harvard University, Cambridge, Mass. U.S. National Herbarium, Smithonian Institution, Washington, DC. New York Botanical Gardens, Bronx Park, Fordham Br.P.O., N.Y. Bot. Gardens, Ann. Arbor, Mich. University of

Accounting for disagreements on average cone loss rates in retinitis pigmentosa with a new kinetic model: Its relevance for clinical trials.

Science.gov (United States)

Baumgartner, W A; Baumgartner, A M

2016-04-01

Since 1985, at least nine studies of the average rate of cone loss in retinitis pigmentosa (RP) populations have yielded conflicting average rate constant values (-k), differing by 90-160%. This is surprising, since, except for the first two investigations, the Harvard or Johns Hopkins' protocols used in these studies were identical with respect to: use of the same exponential decline model, calculation of average -k from individual patient k values, monitoring patients over similarly large time frames, and excluding data exhibiting floor and ceiling effects. A detailed analysis of Harvard's and Hopkins' protocols and data revealed two subtle differences: (i) Hopkins' use of half-life t0.5 (or t(1/e)) for expressing patient cone-loss rates rather than k as used by Harvard; (ii) Harvard obtaining substantially more +k from improving fields due to dormant-cone recovery effects and "small -k" values than Hopkins' ("small -k" is defined as less than -0.040 year(-1)), e.g., 16% +k, 31% small -k, vs. Hopkins' 3% and 6% respectively. Since t0.5=0.693/k, it follows that when k=0, or is very small, t0.5 (or t(1/e)) is respectively infinity or a very large number. This unfortunate mathematical property (which also prevents t0.5 (t(1/e)) histogram construction corresponding to -k to +k) caused Hopkins' to delete all "small -k" and all +k due to "strong leverage". Naturally this contributed to Hopkins' larger average -k. Difference (ii) led us to re-evaluate the Harvard/Hopkins' exponential unchanging -k model. In its place we propose a model of increasing biochemical stresses from dying rods on cones during RP progression: increasing oxidative stresses and trophic factor deficiencies (e.g., RdCVF), and RPE malfunction. Our kinetic analysis showed rod loss to follow exponential kinetics with unchanging -k due to constant genetic stresses, thereby providing a theoretical basis for Clarke et al.'s empirical observation of such kinetics with eleven animal models of RP. In

[Activities of Harvard College Observatory

Science.gov (United States)

Dalgarno, A.; Smith, Peter L.; Stark, G.; Yoshino, K.

2002-01-01

With support from this grant, we have: 1) Developed techniques for improving wavelengths and f-values for singly and doubly charged ions of the iron group and have improved the accuracy of Fe III wavelengths by an order of magnitude. New Fe II f-values have also resulted from this work. 2) Measured line oscillator strengths and photoabsorption cross sections for UV molecular spectral feature that have been, or could be, used for searches for and detection of molecules in diffuse and translucent interstellar clouds and for determination of molecular column densities there. In addition, we have determined other molecular parameters -- line assignments, wavelengths, and line widths -- that are essential for theoretical descriptions of the abundance, fractionation, and excitation of interstellar molecules and for comparison of predictions with observations. 3) Measured A-values for spin-changing and other weak lines in low-Z ions. When A-values are available, these spectral features are useful for astrophysical plasma density and temperature diagnostics. Such lines are also used in interstellar abundance determinations in cases where the stronger allowed lines are saturated in astronomical spectra. 4) Taken an activist approach to ensuring that, (i), astronomers have ready access to our data, and, (ii), avenues of communication between data users and producers are strengthened.

Harvard Business School energy report

International Nuclear Information System (INIS)

Stobaugh, R.; Yergin, D.

1979-01-01

With the help of cost-benefit calculations which include also the - to a great extent - neglected external resp. social costs the team of authors of the Havard Businees School conclude that energy conservation as well as alternative energies as solar energy are the most important energy sources of the future - a conclusion which clearly contradicts the present prevailing opinion according to which the expansion of energy consumption and the improvement of power supply by nuclear power plants are indispensable for the securing of economic growth and the economic structure. Although the authors keep up an option for nuclear energy (as it may perhaps be possible to solve the problem of radioactive waste disposal) they put forward the sober statement that - last not least because of its questionable economic efficiency - nuclear power cannot be a solution to energy crisis for the rest of the century, let alone to the politically precarious dependence of the Western Countries on the Saudi-Arabic import oil. The Havard Analysis is based on the latest numerical data and it is not only valid for the USA. It shall have even more impact for a country like the Federal Republic of Germany which is short of raw material. Therefore the American figures are put in relation to the German situation in an additional chapter. (orig./UA) [de

Disruptive Technology: What Is It? How Can It Work for Professional Writing?

Science.gov (United States)

Godwin, Mary

2010-01-01

Writing in 1995 for the "Harvard Business Review" audience of executive managers, Harvard business professor Clayton Christensen coined the term "disruptive technologies" to describe innovations that improve a product, service, or operation in ways wholly unanticipated by leaders of existing markets. Christensen's economic theory offers a launch…

Cosmic ray-induced spallation recoil tracks in meteoritic phosphates: simulation at the CERN synchrocyclotron

Energy Technology Data Exchange (ETDEWEB)

Perron, C [Centre National de la Recherche Scientifique (CNRS), 75 - Paris (France). Inst. d` Astrophysique; [Museum National d` Histoire Naturelle, 75 - Paris (France)

1994-12-31

Annealed meteoritic phosphate crystals have been irradiated by 600 MeV protons to simulate cosmic ray irradiation in space. Spallation recoil tracks were then revealed, which mimic fission tracks, specially when observed in the SEM. A production yield of 9.3 {+-} 2.2 x 10{sup 8} spallation track per proton has been obtained for merrillite, and a substantially lower value (2.5 per proton) for apatite. A nominal production yield in space of 6 tracks per year has been derived, which may be used for a rough estimate of spallation track densities in chondritic merrillite. (Author).

Long-term trends of changes in pine and oak foliar nitrogen metabolism in response to chronic nitrogen amendments at Harvard Forest, MA.

Science.gov (United States)

Minocha, Rakesh; Turlapati, Swathi A; Long, Stephanie; McDowell, William H; Minocha, Subhash C

2015-08-01

We evaluated the long-term (1995-2008) trends in foliar and sapwood metabolism, soil solution chemistry and tree mortality rates in response to chronic nitrogen (N) additions to pine and hardwood stands at the Harvard Forest Long Term Ecological Research (LTER) site. Common stress-related metabolites like polyamines (PAs), free amino acids (AAs) and inorganic elements were analyzed for control, low N (LN, 50 kg NH4NO3 ha(-1) year(-1)) and high N (HN, 150 kg NH4NO3 ha(-1) year(-1)) treatments. In the pine stands, partitioning of excess N into foliar PAs and AAs increased with both N treatments until 2002. By 2005, several of these effects on N metabolites disappeared for HN, and by 2008 they were mostly observed for LN plot. A significant decline in foliar Ca and P was observed mostly with HN for a few years until 2005. However, sapwood data actually showed an increase in Ca, Mg and Mn and no change in PAs in the HN plot for 2008, while AAs data revealed trends that were generally similar to foliage for 2008. Concomitant with these changes, mortality data revealed a large number of dead trees in HN pine plots by 2002; the mortality rate started to decline by 2005. Oak trees in the hardwood plot did not exhibit any major changes in PAs, AAs, nutrients and mortality rate with LN treatment, indicating that oak trees were able to tolerate the yearly doses of 50 kg NH4NO3 ha(-1) year(-1). However, HN trees suffered from physiological and nutritional stress along with increased mortality in 2008. In this case also, foliar data were supported by the sapwood data. Overall, both low and high N applications resulted in greater physiological stress to the pine trees than the oaks. In general, the time course of changes in metabolic data are in agreement with the published reports on changes in soil chemistry and microbial community structure, rates of soil carbon sequestration and production of woody biomass for this chronic N study. This correspondence of selected metabolites

Engaging Undergraduates in Economics

Science.gov (United States)

Gajwani, Kiran; Miron, Jeffrey

2015-01-01

Siegfried and Stock (2007) explore the undergraduate training of PhD economists. Their findings show that among U.S. undergraduate economics programs, the Harvard University Economics Department produces many eventual economics PhD recipients. In this article, the authors discuss Harvard's undergraduate economics program and highlight some key…

Hartl, Prof. Daniel L

Indian Academy of Sciences (India)

Hartl, Prof. Daniel L. Date of birth: 1 January 1943. Address: Higgins Professor of Biology, Dept. of Organismic & Evolutionary, Biology, The Biological Lab., Harvard University, 16 Divinity Ave, Cambridge, MA 02138, USA Contact: Office: (+1-617) 496 3917. Email: dhartl@oeb.harvard.edu. YouTube; Twitter; Facebook; Blog ...

77 FR 68891 - Medicare Program; Revisions to Payment Policies Under the Physician Fee Schedule, DME Face-to...

Science.gov (United States)

2012-11-16

... comments, phone 1 (800) 743-3951. Table of Contents To assist readers in referencing sections contained in... from the physician community. A research team at the Harvard School of Public Health developed the..., Harvard worked with panels of experts, both inside and outside the federal government, and obtained input...

76 FR 69927 - Approval of Air Quality Implementation Plans; California; South Coast; Attainment Plan for 1997...

Science.gov (United States)

2011-11-09

...). See TSD at Section II.A (referencing, inter alia, South Coast 2007 AQMP at Appendix III and 2007 State... these assertions, CBE states that: (1) A 2002 Harvard University modeling study \\11\\ concludes that... satisfy RACT/RACM requirements. \\11\\ Fiore, et al, Harvard University, Linking ozone pollution and climate...

Experiment list: SRX150497 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available sue Diagnosis=Fibrocystic Disease 30305817,89.0,5.1,579 GSM935418: Harvard ChipSeq MCF10A-Er-Src EtOH 0.01pc...t 4hr Input std source_name=MCF10A-Er-Src || biomaterial_provider=Struhl laboratory || lab=Harvard || lab description=Struhl - Harvar

Refining the Eye: Dermatology and Visual Literacy

Science.gov (United States)

Zimmermann, Corinne; Huang, Jennifer T.; Buzney, Elizabeth A.

2016-01-01

In 2014 the Museum of Fine Arts Boston and Harvard Medical School began a partnership focused on building visual literacy skills for dermatology residents in the Harvard Combined Dermatology Residency Program. "Refining the Eye: Art and Dermatology", a four session workshop, took place in the museum's galleries and utilized the Visual…

Institutional Repositories: Thinking beyond the Box

Science.gov (United States)

Albanese, Andrew Richard

2009-01-01

In February 2008, the faculty of Arts and Sciences at Harvard University made history, unanimously passing a revolutionary open access mandate that, for the first time, would require faculty to give the university copies of their research, along with a nonexclusive license to distribute them electronically. In the press, Harvard University…

Diet and Cancer: The Fourth Paradigm

Science.gov (United States)

Walter C. Willett, MD, DrPH, an international expert in diet and nutrition, with posts as a Professor of Epidemiology and Nutrition and Chairman of the Department of Nutrition at Harvard School of Public Health and as Professor of Medicine at Harvard Medical School, presented "Diet and Cancer: The Fourth Paradigm".

Databases in Healthcare.

Science.gov (United States)

1980-03-01

the Harvard School of Public Health.) The Division of Biostatistics and Epidemiology in the Sidney Farber Cancer Institute of the Harvard School of...34; NCHSR Research Digest Series, DHEW, Pub. no. (PHS) 78-3219, 1978. Duncan78 Duncan, K.A.: "A Total System for Dentistry " in Information Technology in

Perspectives on "Bakke": Equal Protection, Procedural Fairness, or Structural Justice?

Science.gov (United States)

Tribe, Laurence H.

1979-01-01

The "Bakke" case is examined for what it has to say regarding first the area of equal protection, then the idea of procedural fairness as distinct from accuracy of result, and finally the notion of structural justice. Available from Harvard Law Review, Harvard Law Review Association, Gannett House, Cambridge, Massachusetts 02138; sc…

Fission cross section measurements at intermediate energies

International Nuclear Information System (INIS)

Laptev, Alexander

2005-01-01

The activity in intermediate energy particle induced fission cross-section measurements of Pu, U isotopes, minor actinides and sub-actinides in PNPI of Russia is reviewed. The neutron-induced fission cross-section measurements are under way in the wide energy range of incident neutrons from 0.5 MeV to 200 MeV at the GNEIS facility. In number of experiments at the GNEIS facility, the neutron-induced fission cross sections were obtained for many nuclei. In another group of experiments the proton-induced fission cross-section have been measured for proton energies ranging from 200 to 1000 MeV at 100 MeV intervals using the proton beam of PNPI synchrocyclotron. (author)

Pion minus energy measurement by a multilayer semiconductor spectrometer

International Nuclear Information System (INIS)

Gornov, M.G.; Gurov, Yu.B.; Lapushkin, S.V.

1981-01-01

A technique for determining π - meson energy by a laminated semiconductor spectrometer is described. Results of experimental test of the technique carried out using beams of meson track of the JINR synchrocyclotron and three Si(Li) detectors are given. A specific feature of the technique is that chi 2 criterium with a functional written through exact thicknesses of semiconductor detectors was used for separating events with disturbance of ionization dependence and determining particle energy. It is shown that the absolute resolution can be not worse than 0.5 MeV in a wide energy range. It is concluded that the technique suggested is suitable for measuring energy of any charged particles with indefinite energy release during stoppage [ru

ISOLDE PROGRAMME

CERN Multimedia

Fedosseev, V; Herfurth, F; Scheidenberger, C; Geppert, C; Gorges, C; Ratajczyk, T; Wiederhold, J C; Vogel, S; Munch, M K; Nieminen, P; Pakarinen, J J A; Lecesne, N; Bouzomita, H; Grinyer, J; Marques moreno, F M; Parlog, M; Blank, B A; Pedroza, J; Ghetta, V; Lozeva, R; Zacarias, S M; Guillemaud mueller, D S; Cottereau, E; Cheikh mhamed, M; Tusseau nenez, S; Tungate, G; Walker, P M; Smith, A G; Fitzpatrick, C; Dominik, W M; Karny, M; Ciemny, A A; Nyman, G H; Thies, R M A; Lindberg, S K G; Langouche, G F; Velten, P; Araujo escalona, V I; Boudreau, M; Domnanich, K A; Richter, D; Lutter, R J; Javaji, A; Engel, R Y; Wiehr, S; Nacher gonzalez, E; Jungclaus, A; Ribeiro jimenez, G; Marroquin alonso, I; Cal gonzalez, J; Paziy, V; Salsac, M; Murphy, C; Podolyak, Z F; Bajoga, A D; Butler, P; Pritchard, A; Colosimo, S J; Steer, A N; Fox, S P; Wadsworth, B A; Truesdale, V L; Al monthery, M; Bracco, A; Guttormsen, M S; Badea, M N; Calinescu, S; Ujeniuc, S; Cederkall, J A; Zemlyanoy, S; Donets, E D; Golovkov, M; Schweitzer, D K; Vranicar, A; Harrichunder, S; Ncube, M; Nannini, A; Strisovska, J; Wolf, E; Gerten, R F; Lehnert, J; Rainovski, G I; Pospisil, S; Datta pramanik, U; Benzoni, G; Fedorov, D; Maier, F M; Bonanni, A; Pfeiffer, B; Griesel, T; Wehner, L W; Mikkelsen, M; Recchia, F; Lenzi, S M; Smith, J F; Kelly, C M; Acosta sanchez, L A; Chavez lomeli, E R; De melo bandeira tavares, P M; Vieira, J M; Martins da silva, M A; Lima lopes, A M; Lopes leal, T J; Mader, J; Kessler, P; Laurent, B G; Schweikhard, L C; Marx, G H; Kulczycka, E; Komorowska, M; Da silva, M F; Goncalves marques, C P; Baptista peres, M A; Welander, J E; Reiter, P; Miller, C; Martin sanchez-cano, D; Wiens, A; Blazhev, A A; Braun, N; Cappellazzo, M V; Birkenbach, B; Gerst, R; Dannhoff, M F; Sithole, M J; Bilgier, B; Nardelli, S; Araujo mendes, C M; Agramunt ros, J; Valencia marin, E; Pantea, E; Hessberger, F P; Leduc, A J; Mitsuoka, S; Carbonari, A W; Buchegger, F J; Garzon camacho, A; Dapo, H; Papka, P; Stachura, M K; Stora, T; Marsh, B A; Thiboud, J A; Heylen, H; Antalic, S; Stahl, C; Bauer, C; Thurauf, M; Maass, B; Sturm, S; Boehm, C; Wolf, N R; Ways, M; Steinsberger, T P; Riisager, K; Ruotsalainen, P A; Bastin, B; Duval, F T; Penessot, G; Flechard, X D; Desrues, P; Giovinazzo, J; Kurtukian nieto, T; Ascher, P E L; Roccia, S; Matea, I; Croizet, H A G; Bonnin, C M; Morfouace, P; Smith, A J; Guin, R; Banerjee, D; Gunnlaugsson, H P; Ohtsubo, T; Zhukov, M V; Tengborn, E A; Welker, A; Giannopoulos, E; Dessagne, P; Juscamaita vivanco, Y; Da costa pereira, L M; Hustings, J; Yu, H; Kruecken, R; Nowak, A K; Jankowski, M; Cano ott, D; Galve lahoz, P; Murphy, A S J; Shand, C M; Jones, G D; Herzberg, R; Ikin, P; Revill, J P; Everett, C; Napoli, D R; Scarel, G; Larsen, A; Tornyi, T G; Pascu, S G; Stroe, L; Toma, S; Jansson, K; Dronjak fahlander, M; Krupko, S; Hurst, A M; Veskovic, M; Nikolov, J; Masenda, H; Sibanda, W N; Rocchini, M; Klimo, J; Deicher, M; Wichert, T; Kronenberg, J; Helmke, A; Meliani, Z; Ivanov, V S; Green, B L; Keatings, J M; Kuti, I; Halasz, Z; Henry, M O; Bras de sequeira amaral, V; Espirito santo, F; Da silva, D J; Rosendahl, S; Vianden, R J; Speidel, K; Agarwal, I; Faul, T; Kownacki, J M; Martins correia, J G; Lorenz, K; Costa miranda, S M; Granadeiro costa, A R; Zyabkin, D; Kotthaus, T; Pfeiffer, M; Gironi, L; Jensen, A; Romstedt, F; Constantino silva furtado, I; Heredia cardona, J A; Jordan martin, M D; Montaner piza, A; Zacate, M O; Plewinski, F; Mesli, A; Akakpo, E H; Pichard, A; Hergemoller, F; Neu, W; Fallis starhunter, J P; Voulot, D; Mrazek, J; Ugryumov, V; Savreux, R P; Kojouharov, I M; Kern, R O; Papst, O; Fitting, J; Lauer, M; Kirsebom, O S; Jensen, K L; Jokinen, A; Rahkila, P J; Hager, U D K; Konki, J P; Dubois, M; Orr, N A; Fabian, X; Huikari, J E; Goigoux, T; Magron, C; Zakari, A A; Maietta, M; Bachelet, C E M; Roussiere, B; Li, R; Canavan, R L; Lorfing, C; Foster, R M; Gislason, H P; Shayestehaminzadeh, S; Qi, B; Mukai, M; Watanabe, Y; Willmann, L; Kurcewicz, W; Wimmer, K; Meisel, Z P; Dorvaux, O; Nowacki, F; Koudriavtsev, I; Lievens, P; Delaure, B J P; Neyens, G; Ceruti, S; Bunka, M; Vermeulen, C; Umbricht, C A; De boer, J; Podadera aliseda, I; Alcorta moreno, M; Pesudo fortes, V; Zielinska, M; Korten, W; Wang, C H; Lotay, G J; Mason, P; Rice, S J; Regan, P H; Willenegger, L M; Andreev, A; Yavuzkanat, N; Hass, M; Kumar, V; Valiente dobon, J J; Crespo campo, L; Zamfir, N - V; Deleanu, D; Clisu, C; Jeppesen, H B; Wu, C; Pain, S D; Stracener, D W; Wuosmaa, A H; Szilner, S; Colovic, P; Matousek, V; Venhart, M; Birova, M; Li, X; Stuchbery, A E; Lellep, G M; Chakraborty, S; Leoni, S; Chupp, T; Yilmaz, C; Severin, G; Garcia ramos, J E; Newton, M E; Hadinia, B; Mc glynn, E; Monteiro de sena silvares de carvalho, I; Friedag, P; Figuera, P; Koos, V; Meot, V H; Pauwels, D B; Jancso, A; Srebrny, J; Alves, E J; David bosne, E; Bengtsson, L; Kalkuehler, M; Albers, M; Bharuth-ram, K; Akkus, B; Hemmingsen, L B S; Pedersen, J T; Dos santos redondo, L M; Rubio barroso, B; Algora, A; Kozlov, V; Mavela, D L; Mokhles gerami, A; Keeley, N; Bernardo da silva, E; Unzueta solozabal, I; Schell, J; Szybowicz, M; Yang, X; Plavec, J; Lassen, J; Johnston, K; Coquard, L; Bloch, T P; Bonig, E S; Stegmann, R; Ignatov, A; Paschalis, S; Fernandez martinez, G; Schilling, M; Habermann, T; Von hahn, R; Minaya ramirez, E E; Moore, I D; Wang, Y; Saastamoinen, A J; Grahn, T; Herzan, A; Stolze, S M; Clement, E; Dijon, A; Shornikov, A; Lienard, E; Gibelin, J D; Pain, C; Canchel, G; Simpson, G S; Latrasse, L P; Huang, W; Forest, D H; Billowes, J; Flanagan, K; Strashnov, I; Binnersley, C L; Sanchez poncela, M; Simpson, J; Morrall, P S; Grant, A F; Charisopoulos, S; Lagogiannis, A; Bhattacharya, C; Olafsson, S; Stepaniuk, M; Tornqvist, H T; Heinz, A M; White iv, E R; Courtin, S; Marechal, F; Da silva fenta, A E; De lemos lima, T A; Stryjczyk, M; Dockx, K; Haller, S; Rizzi, M; Reichert, S B; Bonn, J; Thirolf, P G; Garcia rios, A R; Gugliermina, V M; Cubero campos, M A; Sanchez tembleque, V; Benito garcia, J; Senoville, M; Mountford, D J; Gelletly, W; Alharbi, T S T; Wilson, E; Rigby, S V; Andreoiu, C; Paul, E S; Harkness, L J; Judson, D S; Wraith, C; Van esbroeck, K; Wadsworth, R; Cubiss, J G; Harding, R D; Vaintraub, S; Mandal, S K; Scarpa, D; Hoff, P; Syed naeemul, H; Borcea, R; Balabanski, D L; Marginean, R; Rotaru, F; Rudolph, D; Fahlander, C H; Chudoba, V; Kay, B P; Soic, N; Naidoo, D; Veselsky, M; Kliman, J; Raisanen, J A; Dietrich, M; Maung maung than, M M T; Reed, M W; Danchev, M T; Ray, J; Roy, M; Hammen, M; Capponi, L; Veghne csatlos, M M; Fryar, J; Mirzadeh vaghefi, S P; Trindade pereira, A M; De pinho oliveira, G N; Bakenecker, A; Tramm, C; Germic, V; Morel, P A; Kowalczyk, M; Matejska-minda, M; Wolinska-cichocka, M; Ringvall moberg, A; Mantovan, R; Fransen, C H; Radeck, F; Schneiders, D W; Steinbach, T; Vibenholt, J E; Magnussen, M J; Stevnhoved, H M; Comas lijachev, V; Dasenbrock-gammon, N M; Perkowski, J; O'neill, G G; Matveev, Y; Wegner, M; Liu, Z; Perez alvarez, T; Cerato, L; Radchenko, V; Molholt, T E; Tabares giraldo, J A; Srnka, D; Dlouhy, Z; Beck, D; Werner, V R; Homm, I; Eliseev, S; Blaum, K; Probst, M B; Kaiser, C J; Martin, J A; Refsgaard, J; Peura, P J; Greenlees, P T; Auranen, K; Delahaye, P; Traykov, E K; Perez loureiro, D; Mery, A A; Couratin, C; Tsekhanovich, I; Lunney, D; Gaulard, C V; Mottram, A D; Cullen, D M; Das, S K; Van de walle, J; Mazzocchi, C; Jonson, B N G; Woehr, A; Lesher, S R; Zuber, K T; Filippin, L; De witte, H J; Van den bergh, P A M; Raabe, R; Dirkx, D; Parnefjord gustafsson, F O A; Dunlop, R A; Tarasava, K; Gernhaeuser, R A; Weinzierl, W; Berger, C; Wendt, K; Achtzehn, T; Gottwald, T; Schug, M; Rossel, R E; Dominguez reyes, R R; Fraile prieto, L M; Briz monago, J A; Koester, U H; Bunce, M R; Bowry, M D; Nakhostin, M; Shearman, R; Cresswell, J R; Joss, D T; Gredley, A; Groombridge, D; Laird, A M; Aslanoglou, X; Siem, S; Weterings, J A; Renstrom, T; Szpak, B T; Luczkowski, M J; Ghita, D; Bezbakh, A; Soltz, R A; Bollmann, J; Bhattacharya, P; Roy, S; Rahaman, M A; Wlodarski, T; Carvalho soares, J; Barzakh, A; Schertz, F; Froemmgen, N E; Liberati, V; Foy, B E; Baptista barbosa, M; Weinheimer, C P; Zboril, M; Simon, R E; Popescu, L A; Czosnyka, T; Miranda jana, P A; Leimbach, D; Naskrecki, R; Plociennik, W A; Ruchowska, E E; Chiara, C J; Walters, W; Eberth, J H; Thomas, T; Thole, P; Queiser, M T; Lo bianco, G; D'amico, F; Muller, S; Sanchez alarcon, R M; Tain enriquez, J L; Orrigo, S E A; Orlandi, R; Masango, S; Plazaola muguruza, F C; Lepareur, N G; Fiebig, J M; Ceylan, N; Wildner, E; Kowalska, M; Malbrunot, S; Garcia ruiz, R F; Pallada, S; Slezak, M; Roeckl, E; Schrieder, G H; Ilieva, S K; Koenig, K L; Amoretti, M A; Lommen, J M; Fynbo, H O U; Weyer, G O P; Koldste, G T; Madsboll, K; Jensen, J H; Nieminen, A M; Reponen, M; Villari, A; Thomas, J; Saint-laurent, M; Sorlin, O H; Carniol, B; Pereira lopez, J; Grevy, S; Plaisir, C; Marie-jeanne, M J; Georgiev, G P; Etile, A M; Le blanc, F M; Verney, D; Stefan, G I; Assie, M; Suzuki, D; Guillot, J; Vazquez rodriguez, L; Campbell, P; Deacon, A N; Ware, T; Flueras, A; Xie, L; Banerjee, K; Piersa, M; Galaviz redondo, D; Johansson, H T; Schwarz, S; Toysa, A S; Aumont, J; Van duppen, P L E; Atanasov, D; Zadvornaya, A; Renaud, M A; Xu, Z; Garrett, P E; Rapisarda, E; Reber, J A; Mattolat, C F; Raeder, S; Habs, D; Vidal, M; Perez liva, M; Calvo portela, P; Ulla pedrera, F J; Wood, R T; Lalkovski, S; Page, R; Petri, M; Barton, C J; Nichols, A J; Vermeulen, M J; Bloor, D M; Henderson, J; Wilson, G L; De angelis, G; Buerger, A; Modamio hoybjor, V; Klintefjord, M L; Ingeberg, V W; Fornal, B A; Marginean, R; Sava, T; Kusoglu, A; Suvaila, R; Lica, R; Costache, C; Mihai, R; Ionescu, A; Baeck, T M; Hoffman, C R; Sedlak, M; Koskelo, O K; Kyaw myat, K M; Gladnishki, K A; Ganguly, B; Goncalves marques, J; Cardoso, S; Seliverstov, M; Niessen, B D; Gutt, L E; Chapman, R; Spagnoletti, P N; Lopes, C; De oliveira amorim, C; Batista lopes, C M; Araujo, J; Schielke, S J; Daugas, J R; Gaudefroy, L; Chevrier, R; Szunyogh, D M; Napiorkowski, P J; Wrzosek-lipska, K; Wahl, U; Catarino, N; Pereira carvalho alves de sequeira, M; Hess, H E; Holler, A; Bettermann, L; Geibel, K; Taprogge, J; Lewandowski, L T N; Manchado de sola, F; Cakirli mutlu, R B; Das gupta, S; Thulstrup, P W; Heinz, U; Nogwanya, T; Neidherr, D M; Morales lopez, A I; Gumenyuk, O; Peaker, A R; Wakabayashi, Y; Abrahams, K J; Martin montes, E J; Mach, H A; Souza ribeiro junior, I; He, J; Chalil, A; Xing, R; Dos santos augusto, R M; Giles, T J; Dorsival, A; Trujillo hernandez, J S; Kalaninova, Z; Andel, B; Venos, D; Kraemer, J; Saha, S; Neugart, R; Eronen, T O; Kreim, K D; Heck, M K; Goncharov, M; Karthein, J; Julin, R J; Eleon, C; Achouri, N L; Grinyer, G F; Fontbonne, C M; Alfaurt, P; Lynch, K M; Wilkins, S G; Brown, A R; Imai, N; Pomorski, M J; Janiak, L; Nilsson, T; Stroke, H H; Stanja, J; Dangelser, E; Heenen, P; Godefroid, M; Mallion, S N; Gins, W A M; Stegemann, S T; Koszorus, A; Mcnulty, J F; Lin, P; Ohlert, C M; Schwerdtfeger, W; Tengblad, O; Becerril reyes, A D; Perea martinez, A; Martinez perez, M C; Margerin, V; Rudigier, M; Alexander, T D; Patel, Z V; Hammond, N; Wearing, F; Patel, A; Jenkins, D G; Corradi, L; Galtarossa, F; Debernardi, A; Giacoppo, F; Tveten, G M; Malatji, K L; Krolas, W A; Stanoiu, M A; Rickert, E U; Ter-akopian, G; Cline, D; Riihimaeki, I A; Simon, K D; Wagner, F E; Turker, M; Neef, M H; Coombes, B J; Jakubek, J; Vagena, E; Bottoni, S; Nishimura, K; Correia, J; Rodrigues valdrez, C J; Molkanov, P; Adhikari, R; Ostrowski, A N; Hallmann, O; Scheck, M; Wady, P T; Lane, J; Krasznahorkay, A J; Kunne sohler, D; Meaney, A J; Hochschulz, F; Roig, O; Behan, C C; Kargoll, S; Kemnitz, S; Carvalho teixeira, R C; Redondo cubero, A; Tallarida, G; Kaczarowski, R; Finke, F; Linnemann, A; Altenkirch, R; Saed-samii, N; Ansari, S H; Dlamini, W B; Adoons, V N; Ronning, C R; Wiedeking, M; Herlert, A J; Mehl, C V; Judge, S M; Gaertner, D; Divinskyi, S; Karabasov, M O; Zagoraios, G; Boztosun, I; Van zyl, J J; Catherall, R; Lettry, J; Wenander, F J C; Zakoucky, D; Catchen, G L; Noertershaeuser, W; Kroell, T; Leske, J; Shubina, D; Murray, I M; Pancin, J; Delaunay, F; Poincheval, J J L; Audirac, L L; Gerbaux, M T; Aouadi, M; Sole, P G P; Fallot, M P; Onillon, A; Duchemin, C; Formento cavaier, R; Audi, G; Boukhari, A; Lau, C; Martin, J A; Barre, N H; Berry, T A; Procter, T J; Bladen, L K; Axiotis, M; Muto, S; Jeong, S C; Hirayama, Y; Korgul, A B; Minamisono, K; Bingham, C R; Aprahamian, A; Bucher, B M; Severijns, N; Huyse, M L; Ferrer garcia, R; Verlinde, M N S; Romano, N; Maugeri, E A; Klupp, S C; Dehn, M H; Heinke, R M; Naubereit, P; Maira vidal, A; Vedia fernandez, M V; Ibanez garcia, P B; Bruyneel, B J E; Materna, T; Hadynska-klek, K; Al-dahan, N; Alazemi, N; Carroll, R J; Babcock, C; Patronis, N; Eleme, Z; Dhal, A; Sahin, E; Goergen, A; Maj, A; Bednarczyk, P A; Borcea, C; Negoita, F; Suliman, G; Marginean, N M; Sotty, C O; Negret, A L; Nae, S A; Nita, C; Golubev, P I; Knyazev, A; Jost, C U; Petrik, K; Vaeyrynen, S A; Dracoulis, G D; Uher, J; Fernandez dominguez, B; Chakraborty, P; Avigo, R; Falahat, S; Lekovic, F; Dorrer, H J; Mengoni, D; Derkx, X; Angus, L J; Sandhu, K S; Gregor, E; Kelly, N A; Byrne, D J; Haas, H; Lourenco, A A; Sousa pereira, S M; Sousa, J B; De melo mendonca, T M; Tavares de sousa, C; Guerreiro dos santos oliveira custodio, L M; Da rocha rodrigues, P M; Yamaguchi, T; Thompson, P C; Rosenbusch, M; Wienholtz, F; Fischer, P; Iwanicki, J S; Rusek, K M; Hanstorp, D; Vetter, U; Wolak, J M; Park, S H; Warr, N V; Doornenbal, P C; Imig, A; Seidlitz, M; Moschner, K; Vogt, A; Kaya, L; Martel bravo, I; Orduz, A K; Serot, O; Majola, S N; Litvinov, Y; Bommert, M; Hensel, S; Markevich, V; Nishio, K; Ota, S; Matos, I; Zenkevich, A; Picado sandi, E; Forstner, O; Hu, B; Ntshangase, S S; Sanchez-segovia, J

2002-01-01

The experiments aim at a broad exploration of the properties of atomic nuclei far away from the region of beta stability. Furthermore, the unique radioactive beams of over 60~elements produced at the on-line isotope separators ISOLDE-2 and ISOLDE-3 are used in a wide programme of atomic, solid state and surface physics. Around 300 scientists are involved in the project, coming from about 70 laboratories. \\\\ \\\\ The electromagnetic isotope separators are connected on-line with their production targets in the extracted 600 MeV proton or 910~MeV Helium-3 beam of the Synchro-Cyclotron. Secondary beams of radioactive isotopes are available at the facility in intensities of 10$^1

Small-angle p--p elastic scattering at energies between 285 and 572 MeV

International Nuclear Information System (INIS)

Aebischer, D.; Favier, B.; Greeniaus, L.G.; Hess, R.; Junod, A.; Lechanoine, C.; Nikles, J.C.; Rapin, D.; Richard-Serre, C.; Werren, D.W.

1976-01-01

Differential cross sections for elastic p--p scattering have been measured at 285, 348, 398, 414, 455, 497, 530, and 572 MeV kinetic energy. The experiment was performed at the CERN synchrocyclotron, using multiwire proportional chambers placed directly in a proton beam. Scattering was observed for theta between approx. 15 and 10 0 in the laboratory system. The ratio α/sub p/ of the real and imaginary parts of the non-spin-flip nuclear forward amplitude was derived from the interference between the Coulomb and nuclear amplitudes. The values obtained are model dependent, but in this energy range α/sub p/ is positive and decreases with energy. Qualitatively good agreement with dispersion-relation predictions is observed

Induction of Harderian gland tumors in mice by heavy ion irradiation

International Nuclear Information System (INIS)

Alpen, E.L.; Powers-Risius, P.; Fry, R.J.M.; Ainsworth, E.J.; DeGuzman, R.J.; Harrison, L.D.; Havens, V.C.

1983-01-01

This project was undertaken as part of the program to evaluate the biological effects of charged particle beams generated by the LBL Bevelac and 184-Inch Synchrocyclotron. Experiments have been designed to investigate the relationship of LET to the effectivenesss of radiation of different qualities to induce tumors; and to study the factors that may influence the shape of the dose-response curve for cancer induction by high-LET radiation. The Harderian gland in mice has been chosen as a model tumor system. Although the total number of cells in these glands is small and the natural incidence is low (approx. 2.7%) they are reasonably susceptible to the induction of tumors by irradiation

Tritium production in thorium by 135 MeV protons

International Nuclear Information System (INIS)

Lefort, M.; Simonoff, G.; Tarrago, X.; Bibron, R.

1960-01-01

We have measured the cross-section of tritium production by bombardment of thorium by 135 MeV protons in the Orsay synchro-cyclotron. The tritium was separated from the targets by heating in a graphite crucible with a high-frequency generator, under hydrogen gas pressure. Tritiated water was synthesised and the tritium was measured with liquid scintillator. A value of 19.5 ± 0.05 mbarns was obtained for the tritium-cross section and ten percent of tritons have energies higher than 35 MeV. This large cross-section is attributed to a double pick-up process. Reprint of a paper published in Le Journal de Physique et le Radium, t. 20, p. 959, dec 1959 [fr

Minxin Pei, China's Crony Capitalism: The Dynamics of Regime Decay

DEFF Research Database (Denmark)

Brødsgaard, Kjeld Erik

2017-01-01

Book review of: Minxin Pei, China's Crony Capitalism: The Dynamics of Regime Decay. Cambridge, Mass.: Harvard University Press, 2016. 365 pp., including references and index. ISBN 9780674737297.......Book review of: Minxin Pei, China's Crony Capitalism: The Dynamics of Regime Decay. Cambridge, Mass.: Harvard University Press, 2016. 365 pp., including references and index. ISBN 9780674737297....

For Youth, by Youth: A Third Student-Run Homeless Shelter

Science.gov (United States)

Seider, Scott C.

2016-01-01

This past winter, the third student-run homeless shelter in the United States came into being. Two recent Harvard graduates, Sam Greenberg and Sarah Rosenkrantz, who had volunteered at the Harvard Square Homeless Shelter as college students, saw a need within the Boston and Cambridge communities for a homeless shelter serving young adults. Drawing…

Improve Leadership Quality

Institute of Scientific and Technical Information of China (English)

无

2005-01-01

About the Authors Dana Telford is a researcher and guest lecturer at Harvard University and a management consultant with clients in North and South America, the Middle East, and Europe. Dana has appeared on numerous television and radio programs. He earned an MBA from Harvard Business School and has rich experience in business management.

The US and Canadian Army Strategies: Failures in Understanding

Science.gov (United States)

2003-04-07

STRATEGIC INTENT Hamel and Prahalad describe strategic intent as... Prahalad , “ Strategic Intent ”, HBR (May-June 1989). Reprinted 25 July 1997. 64 122 For other interpretations of strategic intent the author...Strategy As Revolution,” Harvard Business Review, July-August, 1996 Hamel, Gary, and C.K. Prahalad ,” Strategic Intent ,” Harvard Business Review,

Summer Nudging: Can Personalized Text Messages and Peer Mentor Outreach Increase College Going among Low-Income High School Graduates?

Science.gov (United States)

Castleman, Benjamin L.; Page, Lindsay C.

2016-01-01

A report released in April 2013 by Benjamin L Castleman of Harvard University and Lindsay C. Page of the Center for Education Policy Research at Harvard University examines the implications of two forms of interventions during the summer between high school and the first year of college on college enrollment. "Summer Nudging: Can Personalized…

Experiment list: SRX150494 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available n-Barr Virus 44912180,85.6,7.7,1806 GSM935415: Harvard ChipSeq GM12878 GCN5 std source_name=GM12878 || bioma...ard || lab description=Struhl - Harvard University || datatype=ChipSeq || datatype ...terial_provider=Coriell; http://ccr.coriell.org/Sections/Search/Search.aspx?PgId=165&q=GM12878 || lab=Harv

Experiment list: SRX150562 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available -Barr Virus 57294082,73.4,6.6,1909 GSM935483: Harvard ChipSeq GM12878 ZZZ3 std source_name=GM12878 || biomat...rd || lab description=Struhl - Harvard University || datatype=ChipSeq || datatype d...erial_provider=Coriell; http://ccr.coriell.org/Sections/Search/Search.aspx?PgId=165&q=GM12878 || lab=Harva

Capital in the Twenty-First Century

DEFF Research Database (Denmark)

Hansen, Per H.

2014-01-01

Review essay on: Capital in the Twenty-First Century. By Thomas Piketty . Translated by Arthur Goldhammer . Cambridge, Mass.: The Belknap Press of Harvard University Press, 2014. viii + 685 pp......Review essay on: Capital in the Twenty-First Century. By Thomas Piketty . Translated by Arthur Goldhammer . Cambridge, Mass.: The Belknap Press of Harvard University Press, 2014. viii + 685 pp...

Nitrogen fertilization decreases forest soil fungal and bacterial biomass in three long-term experiments

Science.gov (United States)

Matthew D. Wallenstein; Steven McNulty; Ivan J. Fernandez; Johnny Boggs; William H. Schlesinger

2006-01-01

We examined the effects of N fertilization on forest soil fungal and bacterial biomass at three long-term experiments in New England (Harvard Forest, MA; Mt. Ascutney, VT; Bear Brook, ME). At Harvard Forest, chronic N fertilization has decreased organic soil microbial biomass C (MBC) by an average of 54% and substrate induced respiration (SIR) was decreased by an...

Page 1 "C e:::::l0•..Cl e: -" s: (,)

African Journals Online (AJOL)

The unit once again got a new commanding officer when Lt D. Mills was promoted to captain on 29 October 1952. On 9 March 1953 tragedy struck the Squa- dron when two Harvards collided in mid-air over Blaauwberg. 2 Lt M. Crous and 2 Lt P. Theron were killed instantly when their air- craft was struck by a Harvard piloted ...

Installing an Ethics Pledge within K-12 Academia: A Restoration of Humanism

Science.gov (United States)

McBath, Gabrielle

2012-01-01

In May 2009, 33 Harvard M.B.A. Candidates proposed and published an ethics pledge entitled the M.B.A. Oath. It is a "voluntary student-led pledge that the goal of business managers is to 'serve the greater good.' It promises that Harvard M.B.A.[s] will act responsibly, ethically, and refrain from advancing their 'own narrow ambitions' at the…

Discovery Driven Growth

DEFF Research Database (Denmark)

Bukh, Per Nikolaj

2009-01-01

Anmeldelse af Discovery Driven Growh : A breakthrough process to reduce risk and seize opportunity, af Rita G. McGrath & Ian C. MacMillan, Boston: Harvard Business Press. Udgivelsesdato: 14 august......Anmeldelse af Discovery Driven Growh : A breakthrough process to reduce risk and seize opportunity, af Rita G. McGrath & Ian C. MacMillan, Boston: Harvard Business Press. Udgivelsesdato: 14 august...

Educational "Goodwill": Measuring the Intangible Assets at Highly Selective Private Colleges and Universities. NBER Working Paper No. 17412

Science.gov (United States)

Nurnberg, Peter; Schapiro, Morton; Zimmerman, David

2011-01-01

In this paper we utilize data on the head-to-head loss rate for students accepted at Williams College, but who opt to enroll elsewhere. For example, we employ data that measure the fraction of students admitted to Williams and to Amherst (or Harvard or Yale, etc.) but who opt to attend Amherst (or Harvard or Yale, etc.) instead of Williams. We…

Oligotyping reveals stronger relationship of organic soil bacterial community structure with N-amendments and soil chemistry in comparison to that of mineral soil at Harvard Forest, MA, USA.

Science.gov (United States)

Turlapati, Swathi A; Minocha, Rakesh; Long, Stephanie; Ramsdell, Jordan; Minocha, Subhash C

2015-01-01

The impact of chronic nitrogen amendments on bacterial communities was evaluated at Harvard Forest, Petersham, MA, USA. Thirty soil samples (3 treatments × 2 soil horizons × 5 subplots) were collected in 2009 from untreated (control), low nitrogen-amended (LN; 50 kg NH4NO3 ha(-1) yr(-1)) and high nitrogen-amended (HN; 150 kg NH4NO3 ha(-1) yr(-1)) plots. PCR-amplified partial 16S rRNA gene sequences made from soil DNA were subjected to pyrosequencing (Turlapati et al., 2013) and analyses using oligotyping. The parameters M (the minimum count of the most abundant unique sequence in an oligotype) and s (the minimum number of samples in which an oligotype is expected to be present) had to be optimized for forest soils because of high diversity and the presence of rare organisms. Comparative analyses of the pyrosequencing data by oligotyping and operational taxonomic unit clustering tools indicated that the former yields more refined units of taxonomy with sequence similarity of ≥99.5%. Sequences affiliated with four new phyla and 73 genera were identified in the present study as compared to 27 genera reported earlier from the same data (Turlapati et al., 2013). Significant rearrangements in the bacterial community structure were observed with N-amendments revealing the presence of additional genera in N-amended plots with the absence of some that were present in the control plots. Permutational MANOVA analyses indicated significant variation associated with soil horizon and N treatment for a majority of the phyla. In most cases soil horizon partitioned more variation relative to treatment and treatment effects were more evident for the organic (Org) horizon. Mantel test results for Org soil showed significant positive correlations between bacterial communities and most soil parameters including NH4 and NO3. In mineral soil, correlations were seen only with pH, NH4, and NO3. Regardless of the pipeline used, a major hindrance for such a study remains to be the lack

Oligotyping reveals stronger relationship of organic soil bacterial community structure with N-amendments and soil chemistry in comparison to that of mineral soil at Harvard Forest, MA, USA

Directory of Open Access Journals (Sweden)

Swathi Anuradha Turlapati

2015-02-01

Full Text Available The impact of chronic nitrogen amendments on bacterial communities was evaluated at Harvard Forest, Petersham MA. Thirty soil samples (3 treatments x 2 soil horizons x 5 subplots were collected in 2009 from untreated (control, low nitrogen-amended (LN; 50 kg NH4NO3 ha-1 yr-1 and high nitrogen-amended (HN; 150 kg NH4NO3 ha-1 yr-1 plots. PCR-amplified partial 16S rDNA sequences made from soil DNA were subjected to pyrosequencing (Turlapati et al., 2013 and analyses using oligotyping. The parameters M (the minimum count of the most abundant unique sequence in an oligotype and s (minimum number of samples in which an oligotype is expected to be present had to be optimized for forest soils because of high diversity and the presence of rare organisms. Comparative analyses of the pyrosequencing data by oligotyping and OTU (Operational Taxonomic Unit clustering tools indicated that the former yields more refined units of taxonomy with sequence similarity of ≥99.5%. Sequences affiliated with 4 new phyla and 73 genera were identified in the present study as compared to 27 genera reported earlier from the same data (Turlapati et al., 2013. Significant rearrangements in the bacterial community structure were observed with N-amendments revealing the presence of additional genera in N-amended plots with the absence of some that were present in the control plots. Permutational MANOVA analyses indicated significant variation associated with soil horizon and N treatment for a majority of the phyla. In most cases soil horizon partitioned more variation relative to treatment and treatment effects were more evident for the organic horizon. Mantel test results for organic soil showed significant positive correlations between bacterial communities and most soil parameters including NH4 and NO3. In mineral soil, correlations were seen only with pH, NH4 and NO3. Regardless of the pipeline used, a major hindrance for such a study remains to be the lack of reference

Clinical results of stereotactic heavy-charged-particle radiosurgery for intracranial angiographically occult vascular malformations

International Nuclear Information System (INIS)

Levy, R.P.; Fabrikant, J.I.; Phillips, M.H.; Frankel, K.A.; Steinberg, G.K.; Marks, M.P.; DeLaPaz, R.L.; Chuang, F.Y.S.; Lyman, J.T.

1989-12-01

Angiographically occult vascular malformations (AOVMs) of the brain have been recognized for many years to cause neurologic morbidity and mortality. They generally become symptomatic due to intracranial hemorrhage, focal mass effect, seizures or headaches. The true incidence of AOVMs is unknown, but autopsy studies suggest that they are more common than high-flow angiographically demonstrable arteriovenous malformations (AVMs). We have developed stereotactic heavy-charged-particle Bragg peak radiosurgery for the treatment of inoperable intracranial vascular malformations, using the helium ion beams at the Lawrence Berkeley Laboratory 184-inch Synchrocyclotron and Bevatron. This report describes the protocol for patient selection, radiosurgical treatment planning method, clinical and neuroradiologic results and complications encountered, and discusses the strengths and limitations of the method. 10 refs., 1 fig

CAMAC-system for calibration and control of experimental apparatus with scintillation counters

International Nuclear Information System (INIS)

Petrov, A.G.; Sinaev, A.N.

1977-01-01

The CAMAC-system is described, connected to the minicomputer PH-2116C, for calibration and control of an experiment on pion scattering on He-nuclei performed with a streamer chamber triggered by a scintillation hodoscope. The following operations are performed: -delay calibration in telescope and hodoscope tracts involving 22 scintillation counters; -control of relative efficiency of hodoscope counters and other parameters of the experiments; -control of HV supply of photomultipliers; -control of the currents of magnets and lenses of the muon track of the synchrocyclotron; -measurement of pulse-hight spectra from a Cherenkov counter to determine the beam composition. The working programs are initiated and the dialogue with the computer is carried out using an alphanumerical display connected to the PH-2116C via a CAMAC interface

Arguments pro and contra the European laboratory in the participating countries

International Nuclear Information System (INIS)

Hermann, A.

1989-01-01

This chapter looks at how the decisions to participate in CERN, the European high energy particle physics laboratory founded in the 1950s, were made by certain participating countries, namely the United Kingdom, France, Italy and Germany. The idea of a united Europe was given high priority in France, Italy and Germany, all of which lacked accelerators and lagged behind the United Kingdom (UK), with its 400MeV Liverpool synchrocyclotron, in nuclear physics research. The UK thus remained as observer only until CERN was officially founded in September 1954. The French were particularly anxious to gain national prestige by influencing the development of the organization. All agreed that from the political point of view, developed science guarantees a high level of war technology. (UK)

Cross Sections for the Production of Residual Nuclides by Proton-Induced Reactions with Uranium at Medium Energies

International Nuclear Information System (INIS)

Issa, S.A.M.; Michel, R.; Uosif, M.A.M.; Issa, S.A.M.; Flamentc, J.L.; David, J.C.; Leray, S.

2009-01-01

The production of residual nuclides by proton-induced reactions on uranium is investigated using activated targets from irradiation experiments at Saturne II synchrocyclotron at the Laboratory National Saturne/Saclay. These investigations contribute to the European research project NUDATRA within the IP EUROTRANS in which the feasibility of accelerator-driven transmutation of nuclear waste is evaluated. Experimental cross sections are derived from gamma-spectrometric measurements. A total of 1894 cross-section was deter-mined covering 44 residual nuclides in the energy range from 211 MeV to 2530 MeV. The experimental data together with those of earlier work of our group are discussed in the context of theoretical excitation functions calculated by the newly developed INCL4 + ABLA and the TALYS codes

Medical Cyclotrons

Science.gov (United States)

Friesel, D. L.; Antaya, T. A.

Particle accelerators were initially developed to address specific scientific research goals, yet they were used for practical applications, particularly medical applications, within a few years of their invention. The cyclotron's potential for producing beams for cancer therapy and medical radioisotope production was realized with the early Lawrence cyclotrons and has continued with their more technically advanced successors — synchrocyclotrons, sector-focused cyclotrons and superconducting cyclotrons. While a variety of other accelerator technologies were developed to achieve today's high energy particles, this article will chronicle the development of one type of accelerator — the cyclotron, and its medical applications. These medical and industrial applications eventually led to the commercial manufacture of both small and large cyclotrons and facilities specifically designed for applications other than scientific research.

Clinical results of stereotactic heavy-charged-particle radiosurgery for intracranial angiographically occult vascular malformations

Energy Technology Data Exchange (ETDEWEB)

Levy, R.P.; Fabrikant, J.I.; Phillips, M.H.; Frankel, K.A.; Steinberg, G.K.; Marks, M.P.; DeLaPaz, R.L.; Chuang, F.Y.S.; Lyman, J.T.

1989-12-01

Angiographically occult vascular malformations (AOVMs) of the brain have been recognized for many years to cause neurologic morbidity and mortality. They generally become symptomatic due to intracranial hemorrhage, focal mass effect, seizures or headaches. The true incidence of AOVMs is unknown, but autopsy studies suggest that they are more common than high-flow angiographically demonstrable arteriovenous malformations (AVMs). We have developed stereotactic heavy-charged-particle Bragg peak radiosurgery for the treatment of inoperable intracranial vascular malformations, using the helium ion beams at the Lawrence Berkeley Laboratory 184-inch Synchrocyclotron and Bevatron. This report describes the protocol for patient selection, radiosurgical treatment planning method, clinical and neuroradiologic results and complications encountered, and discusses the strengths and limitations of the method. 10 refs., 1 fig.

Beta-delayed proton emitter $^{113}Xe$

CERN Document Server

Hagberg, E; Jonson, B; Jørgensen, B; Kugler, E; Mowinckel, T

1973-01-01

The ISOLDE facility at the CERN synchrocyclotron has been used for extending the series of beta -delayed proton emitters in xenon to masses lighter than those previously observed (/sup 115,117/Xe). Owing to the rapid decrease of the yields, experiments with solid-state counters were inconclusive, and instead a new and much more sensitive method based on nuclear emulsions was developed. The mass range 111-114 showed one new activity, /sup 113/Xe, with a half-life of 2.8+or-0.2 sec. From measurements of the track lengths for a total of 1130 protons from /sup 113/Xe it was possible to determine the energy spectrum. The results extend the systematics of beta -strength functions in the light xenon isotopes. (19 refs).

Small-angle p-p elastic scattering at energies between 285 and 572 Me V

CERN Document Server

Aebischer, D; Greeniaus, L G; Hess, R; Junod, A; Lechanoine-Leluc, C; Nikles, J C; Rapin, D; Serre, Claude; Werren, D W

1976-01-01

Low energy proton-proton elastic scattering has been studied using an arrangement of multiwire proportional chambers at the CERN synchrocyclotron. Accurate measurements of the angular distribution for laboratory scattering angles in the range 1.5 to 10 degrees have been made at eight incident kinetic energies between 285 and 572 MeV. The interferences between the Coulomb and nuclear scattering amplitudes is used to determine the ratio alpha /sub p/=Re phi /sup N //sub +/(o)/Im phi /sup N//sub +/(o), where phi /sup N//sub +/(o) is the non-flip nuclear forward amplitude. alpha p is found to be positive and falling with energy, but is sensitive to the type of parameterization used. Reasonable consistency with dispersion relation calculations is obtained. (21 refs).

Car Talk: Ethnic And Religious Identity In The Central African Republic

Science.gov (United States)

2017-12-01

distinctions and can aide mobilizers both internally and externally.15 Now that the fact that identities can shift or change has been established, it is...Civil War, and International Order,” BCSIA Discussion Papers, Kennedy School of Government, Harvard University (2006): 1; Alexander De Juan, “A Pact... International Order.” BCSIA Discussion Papers, Kennedy School of Government, Harvard University, 2006, 1. United States Commission on International

Army Transformation: Navigating into the Blue Ocean

Science.gov (United States)

2012-03-22

learning, customisable and transformational organization, where education is a continuous process, and knowledge acquired by the organization transcends... Mass .: Harvard Business School Press, 2005). 12 According to 2011 estimates, the population of Malaysia in 2011 is 28.3 million people. 67.4% are...in any significant way. John P. Kotter, Leading Change (Boston, Mass .: Harvard Business Review Press, 1996) 30. 22 32 These are ongoing schemes

The psychological toll of slum living—an assessment of mental health, disability, and slum-related adversities in Mumbai, India

Directory of Open Access Journals (Sweden)

Dr. Ramnath Subbaraman, MD

2014-05-01

Funding: The Fogarty International Clinical Research Fellows Program at Vanderbilt (R24 TW007988, Harvard T32 post-doctoral clinical research fellowship (NIAID AI 007433, the Eunice Kennedy Shriver National Institute for Child Health and Human Development (5R24HD047879, the National Institutes of Health (5T32HD007163, the Rockefeller Foundation, and the Weatherhead Center for International Affairs at Harvard University.

Mission from Anti-Terrorism to Peace in Sri Lanka

Science.gov (United States)

2009-03-24

citizens working together. Endnotes 1 Asoka Bandarage, “The Sri Lankan Conflict a Multi-Polar Approach,” Harvard International Review, 15 June 2008...8 Asoka Bandarage, “The Sri Lankan Conflict a Multi-Polar Approach”, Harvard International Review, 15 June 2008, available from...Eastern University Press, 2003), 222. 24 H. Kaunaratna. BA (Ceylon) University of Peradeniya, Sri Lanka, interviewed by author, 25 November 2008. 25 Asoka

Millions and Billions of Channels

Science.gov (United States)

Leigh, Darren; Horowitz, Paul

The history of the Harvard SETI group is inextricably linked with the history of Paul Horowitz. Horowitz became enamored with SETI as a student at Harvard, reading Ed Purcell's paper "Radio Astronomy and Communication Through Space" (Purcell, 1960), discussing with his roommates a class that Carl Sagan was teaching there using a draft of Shklovskii and Sagan's "Intelligent Life in the Universe" (Shklovskii and Sagan, 1966) as a text, and finally attending a Loeb Lecture series at Harvard by Frank Drake (Drake, 1969). The series was officially about pulsars but Drake did manage to slip in one inspiring talk about SETI. Horowitz says that "It was this lecture that launched me into this field; it was a revelation that you could go beyond idle speculation - you could actually calculate stuff."

Risk Stratification of Stress Fractures and Prediction of Return-to-Duty

Science.gov (United States)

2016-12-01

mgh.harvard.edu; mbouxsei@bidmc.harvard.edu 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Massachusetts General Hospital AND...ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Boston, MA 02114-2554 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR...with recent stress fracture enrolled. 15. SUBJECT TERMS bone microarchitecture, HRpQCT, race, gender , sex, bone mineral density, vBMD, bone geometry

Don’t Ask, Don’t Tell: Law or DoD Policy Deciphering the Differences

Science.gov (United States)

2009-12-11

the Gay Ban Undermines the Military and Weakens America. New York: St Martin’s Press, 2009. Goleman , Daniel , Richard E. Boyatzis, and Annie McKee...Primal Leadership: Learning to Lead with Emotional Intelligence . Harvard: Harvard Business Press, 2004. Hall, Kermit L. The Oxford Companion to...differences in the language and the policies in order to speak intelligently about the issues and propose solutions that are logical and in consonance with

MYC RNAi-PT Combination Nanotherapy for Metastatic Prostate Cancer Treatment

Science.gov (United States)

2017-10-01

Women’s Hospital (BWH)/Harvard Medical School (HMS), Partnering PIs Dr. Charles Bieberich from the University of Maryland Baltimore County (UMBC) and Dr...BWH)/Harvard Medical School (HMS), Partnering PIs Dr. Charles Bieberich from the University of Maryland Baltimore County (UMBC) and Dr. Angelo De...siRNA in cytotoxicity studies with Pt-resistant PC3 cells. Simultaneously, the Pt-resistant cells will be given to Drs. De Marzo and Yegnasubramanian

5. Bibliographie de D. N. McCloskey1

OpenAIRE

2014-01-01

Ouvrages individuels Histoire économique Economic Maturity and Entrepreneurial Decline : British Iron and Steel, 1870-1913, Boston, Harvard University Press (Harvard Economic Studies), 1973. (David A. Wells Prize.) Enterprise and Trade in Victorian Britain : Essays in Historical Economics, Londres / Boston, Allen and Unwin, 1981 (2e édition, 1993). Econometric History, British Economic History Society, Houndmills, Basingstoke, Hampshire, Macmillan, 1987. Critique économique et historique The ...

A Framework for Human Microbiome Research

Science.gov (United States)

2012-06-14

Biostatistics President and Fellows of Harvard College Boston, MA 02115 -6028 REPORT DOCUMENTATION PAGE b. ABSTRACT UU c. THIS PAGE UU 2. REPORT TYPE...Institute for Genome Sciences 801 W. Baltimore Street, Baltimore, Maryland 21201, USA. 4Harvard School of Public Health, Department of Biostatistics , 655...School of Dentistry , Department of Periodontics, 6516 MD Anderson Blvd, Houston, Texas 77030, USA. 50San Diego State University, Department of Biology

Tendencias actuales de citación en los trabajos de investigación filosófica Modern referencing trends in philosophical research papers

OpenAIRE

Gemma Muñoz-Alonso López

2006-01-01

El artículo propone unificar los criterios para citar y elaborar bibliografías en la investigación en filosofía y en ciencias humanas. Se analizan las ventajas y los inconvenientes del sistema tradicional y del sistema Harvard.The paper attempts to unify criteria for referencing documents and elaborating bibliographies in philosophy and human sciences research. The advantages and disadvantages of the Harvard system are confronted with more traditional methods.

The Future of Learning Institute

DEFF Research Database (Denmark)

Chemi, Tatiana

2009-01-01

this article describes Harvard University’s learning institute, which focuses on several fundamental issues on the future of learning. Specific focus is given to the effect og globalising, digitalising and brain research on learning and education.......this article describes Harvard University’s learning institute, which focuses on several fundamental issues on the future of learning. Specific focus is given to the effect og globalising, digitalising and brain research on learning and education....

Language and Empire, c. 1800

OpenAIRE

Rothschild, Emma

2005-01-01

Emma Rothschild is director of the Centre for History and Economics at King’s College, Cambridge, and Visiting Professor of History at Harvard University. Recent publications include Economic Sentiments: Adam Smith, Condorcet and the Enlightenment (Harvard University Press, 2001), "Global Commerce and the Question of Sovereignty in the 18th Century Provinces" (Modern Intellectual History, 2004) and “Real, Pretended or Imaginary Dangers” (The New York Review of Books, 2004). She is working on ...

Water demand prediction using artificial neural networks and support vector regression

CSIR Research Space (South Africa)

Msiza, IS

2008-11-01

Full Text Available Neural Networks and Support Vector Regression Ishmael S. Msiza1, Fulufhelo V. Nelwamondo1,2, Tshilidzi Marwala3 . 1Modelling and Digital Science, CSIR, Johannesburg,SOUTH AFRICA 2Graduate School of Arts and Sciences, Harvard University, Cambridge..., Massachusetts, USA 3School of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg, SOUTH AFRICA Email: imsiza@csir.co.za, nelwamon@fas.harvard.edu, tshilidzi.marwala@wits.ac.za Abstract— Computational Intelligence techniques...

Journal of Special Operations Medicine. Volume 10, Edition 3, Summer 2010

Science.gov (United States)

2010-01-01

Harvard School of Public Health at (www.hsph.harvard.edu) 5. Journal of Nutrition at (www.jn.nutrition.org) 6. University of Maryland Medical Center at... recoveries , manifested as large swings in vital signs that increased the overall data range (i.e., vital sign variability) even in the absence of strong...whether it was baseball, basketball, soccer , or football. Now add to that the 10-15 years lifespan of active Special Operations deployments, where

Extensible Open-Source Zero-Footprint Web Viewer for Oncologic Imaging Research | Informatics Technology for Cancer Research (ITCR)

Science.gov (United States)

The Tumor Imaging Metrics Core (TIMC), a CCSG Shared-Resource of the Dana-Farber/Harvard Cancer Center, has developed software for managing the workflow and image measurements for oncology clinical trials. This system currently is in use across the five Harvard hospitals to manage over 600 active clinical trials, with 800 users, and has been licensed and implemented at several other Cancer Centers, including Yale, Utah/Huntsman Cancer Institute, and UW/Seattle Cancer Care Alliance.

Lisa B Signorello, ScD, ScM | Division of Cancer Prevention

Science.gov (United States)

Lisa Signorello is the Director and Chief of the Cancer Prevention Fellowship Program (CPFP) Branch in the National Cancer Institute's Division of Cancer Prevention. Dr. Signorello served as Deputy Director of the CPFP from August 2014 to November 2017 and came to the NCI after having held academic positions at the Harvard School of Public Health, Harvard Medical School, and Vanderbilt University, as well as having had significant private sector research experience. |

Modern referencing trends in philosophical research papers

OpenAIRE

Muñoz-Alonso López, Gemma

2006-01-01

El artículo propone unificar los criterios para citar y elaborar bibliografías en la investigación en filosofía y en ciencias humanas. Se analizan las ventajas y los inconvenientes del sistema tradicional y del sistema Harvard.The paper attempts to unify criteria for referencing documents and elaborating bibliographies in philosophy and human sciences research. The advantages and disadvantages of the Harvard system are confronted with more traditional methods.

Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study.

Science.gov (United States)

Rabin, Jennifer S; Schultz, Aaron P; Hedden, Trey; Viswanathan, Anand; Marshall, Gad A; Kilpatrick, Emily; Klein, Hannah; Buckley, Rachel F; Yang, Hyun-Sik; Properzi, Michael; Rao, Vaishnavi; Kirn, Dylan R; Papp, Kathryn V; Rentz, Dorene M; Johnson, Keith A; Sperling, Reisa A; Chhatwal, Jasmeer P

2018-05-21

Identifying asymptomatic individuals at high risk of impending cognitive decline because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk and β-amyloid (Aβ) pathology commonly co-occur in older adults and are significant causes of cognitive impairment. To determine whether vascular risk and Aβ burden act additively or synergistically to promote cognitive decline in clinically normal older adults; and, secondarily, to evaluate the unique influence of vascular risk on prospective cognitive decline beyond that of commonly used imaging biomarkers, including Aβ burden, hippocampal volume, fludeoxyglucose F18-labeled (FDG) positron emission tomography (PET), and white matter hyperintensities, a marker of cerebrovascular disease. In this longitudinal observational study, we examined clinically normal older adults from the Harvard Aging Brain Study. Participants were required to have baseline imaging data (FDG-PET, Aβ-PET, and magnetic resonance imaging), baseline medical data to quantify vascular risk, and at least 1 follow-up neuropsychological visit. Data collection began in 2010 and is ongoing. Data analysis was performed on data collected between 2010 and 2017. Vascular risk was quantified using the Framingham Heart Study general cardiovascular disease (FHS-CVD) risk score. We measured Aβ burden with Pittsburgh Compound-B PET. Cognition was measured annually with the Preclinical Alzheimer Cognitive Composite. Models were corrected for baseline age, sex, years of education, and apolipoprotein E ε4 status. Of the 223 participants, 130 (58.3%) were women. The mean (SD) age was 73.7 (6.0) years, and the mean (SD) follow-up time was 3.7 (1.2) years. Faster cognitive decline was associated with both a higher FHS-CVD risk score (β = -0.064; 95% CI, -0.094 to -0.033; P < .001) and higher Aβ burden (β = -0.058; 95% CI, -0.079 to -0.037; P < .001). The interaction of the FHS-CVD risk score and Aβ burden with time

Transport of one SC coil through the village of Meyrin

CERN Multimedia

1956-01-01

In 1952, before CERN was officially founded, two accelerator projects were launched: one for an innovative accelerator to operate at an energy level unequalled at the time, the other for a more standard machine, a Synchro-Cyclotron (SC) to operate at 600 MeV. Design work on the SC was started in 1952 and carried out by teams scattered throughout Europe. Once construction began in 1954, CERN had to arrange road transport for the first of what has since been a long series of spectacular component deliveries, such as those of the machine's two magnetic coils each weighing 60 tonnes and measuring 7.2 metres in diameter. Above, one of them is seen passing through the village of Meyrin. The SC was commissioned in 1957 and was operational for 34 years!

Measurements of multipolarities in 227Ra as tests of evidence for stable octupole deformation

International Nuclear Information System (INIS)

Borge, M.J.G.; Burke, D.G.; Gietz, H.; Hill, P.; Kaffrell, N.

1987-01-01

Multipolarities of ∝30 transitions in 227 Ra have been established by measuring conversion electrons following the β - decay of 227 Fr. For this purpose a 'mini-orange'-type electron spectrometer has been constructed. The 227 Fr isotopes were produced by the ISOLDE on-line separator at the CERN Synchro-cyclotron. Internal conversion coefficients were obtained from singles spectra and also from simultaneous γe - and γγ coincidence measurements. The new results support the placement of levels and transitions in the earlier level scheme but require changes in the previously assigned parities for four of the levels. Also, one E0 transition was identified. The results are consistent with previous interpretations for most of the levels that have been used to argue in favour of a small permanent octupole deformation for 227 Ra. (orig.)

The Paradox of Fight or Flight - A Leadership Guide to Understanding and Mitigating Operational Stress Injuries

Science.gov (United States)

2006-04-01

Forces,” Canadian Military Journal 1, no. 3 (Autumn 2000): 35. 56 Brown, “Notes on Nostalgia… 57 Craig Lambert, “ Hypochondria of the Heart,” Harvard...59 Brown, “Notes on Nostalgia… 60 Craig Lambert, “ Hypochondria of the Heart… 61 Toffler and Toffler, War and Anti-war…, 38. 62 Ibid. 63 The...Sons Ltd., 1991. Lambert, Craig. “ Hypochondria of the Heart.” Harvard Magazine 104, no. 1 (September-October 2001): Journal on-line; available

Purcell and NMR

Science.gov (United States)

Bloembergen, Nicolaas

2012-02-01

In 1946 and 1947 the author carried out research at Harvard University under the guydance of Professor Edward M.Purcell. The results were communicated in a frequently cited paper,often referred to as BPP, after the authors Bloembergen, Purcell and Pound. The same material appeared in my 1948 Ph. D. Leiden thesis ``Nuclear Magnetic Relaxation.'' Some personal interactions with Ed Purcell and Bob Pound in these early and in later years at Harvard will be recounted.

Evaluating the Contribution of Climate Forcing and Forest Dynamics to Accelerating Carbon Sequestration by Forest Ecosystems in the Northeastern U.S.: Final Report

Energy Technology Data Exchange (ETDEWEB)

Munger, J. William [Harvard University, SEAS; Foster, David R. [Harvard University, Harvard Forest; Richardson, Andrew D. [Harvard University, OEB

2014-10-01

This report summarizes work to improve quantitative understanding of the terrestrial ecosystem processes that control carbon sequestration in unmanaged forests It builds upon the comprehensive long-term observations of CO2 fluxes, climate and forest structure and function at the Harvard Forest in Petersham, MA. This record includes the longest CO2 flux time series in the world. The site is a keystone for the AmeriFlux network. Project Description The project synthesizes observations made at the Harvard Forest HFEMS and Hemlock towers, which represent the dominant mixed deciduous and coniferous forest types in the northeastern United States. The 20+ year record of carbon uptake at Harvard Forest and the associated comprehensive meteorological and biometric data, comprise one of the best data sets to challenge ecosystem models on time scales spanning hourly, daily, monthly, interannual and multi-decadal intervals, as needed to understand ecosystem change and climate feedbacks.

Budget projections 1990, 1991, and 1992 for research in high energy nuclear physics

International Nuclear Information System (INIS)

1990-05-01

Research programs in experimental high energy physics are carried out at Harvard under the general supervision of a departmental faculty committee on high energy physics. The committee members are: G.W. Brandenburg, M. Franklin, S. Geer, R. J. Glauber, K. Kinoshita, F. M. Pipkin, R. F. Schwitters, K. Strauch, M. E. Law, and R. Wilson. Of these individuals, Professors R.J. Glauber, F.M. Pipkin, R.F.Schwitters, K. Strauch, and R. Wilson are the principal investigators with whom a number of junior faculty members and post-doctoral research fellows are associated. Dr. Brandenburg is the Director of the High Energy Physics Laboratory and administers the DOE high energy physics contract. Professor Schwitters is currently on leave of absence as Director of the Superconducting Super Collider project. In the fall of 1990 Professor G. Feldman, who is currently at SLAC, will join the Harvard faculty and become a principal investigator. Harvard is planning to make one or two additional senior faculty appointments in experimental high energy physics over the next two years. The principal goals of the work described here are to carry out forefront programs in high energy physics research and to provide first rate educational opportunities for students. The experimental program supported through HEPL is carried out at the major accelerator centers in the world and addresses some of the most important questions in high energy physics. Harvard's educational efforts are concentrated in graduate education. These budget projections cover all of the Harvard based high energy physics experimental activities. The open-quotes umbrellaclose quotes nature of this contract greatly simplifies support of essential central technical and computer services and helps the group to take advantage of new physics opportunities and to respond to unexpected needs. The funding for the operation of the HEPL facility is shared equally by the experimental groups

Encounters with John Van Vleck: Elevating the Self-Esteem of an Experimentalist

Science.gov (United States)

Wynne, James

2011-03-01

As a Harvard freshman in 1960, John H. Van Vleck was assigned to guide me through physics course selections. As a Harvard first year graduate student in 1964, I took his course on Group Theory. He was an esteemed theoretician, and I was an experimentalist. Nevertheless, I liked him, and he both educated me and gave me good advice. Later, I learned that Van Vleck was responsible for bringing Nicolaas Bloembergen, my Ph. D. advisor, back to Harvard from Holland, with a faculty appointment in the Division of Engineering and Applied Physics. (Bloembergen had done his Ph.D. thesis with Ed Purcell, making NMR into a science, and Purcell was one of the best teachers I encountered in 9 years at Harvard.) Stepping forward in time to May, 1969, just after defending my doctoral thesis, I ran into Van Vleck in the hallway. I told him I had earned my Ph.D., and he asked me what I had done for my thesis. Feeling defensive while talking to a great theoretician, I started out cautiously to say that I had built a carbon dioxide laser. He immediately started praising me as the best of the breed, someone who could build things and actually make them work. The praise continued, he told some stories (which I will share), and I left the building on ``Cloud 9.'' It was a really good day.

High Resolution Astrophysical Observations Using Speckle Imaging

Science.gov (United States)

1986-04-11

reserved. Printed in U.S A . A NEW OPTICAL SOURCE ASSOCIATED WITH T TAURI P. NISENSON, R. V. STACHNIK, M. KAROVSKA , AND R. NOYES Harvard-Smithsonian Center...NISENSON, STACHNIK, KAROVSKA . AND NoYEs (see page L18) APPENDIX F ON THE a ORIONIS TRIPLE SYSTEM M. Karovska , P. Nisenson, R. Noyes Harvard-Smithsonian...3.5 and 4.0 at a wavelengtRh of 530 nm. In Addition, Karovska (1984) inferred the possible existence of a second companion from an image recon

The Drawings of the Florentine Painters: From Print Catalog to Linked Open Data

Directory of Open Access Journals (Sweden)

Lukas Klic,

2017-10-01

Full Text Available The Drawings of The Florentine Painters project created the first online database of Florentine Renaissance drawings by applying Linked Open Data (LOD techniques to a foundational text of the same name, first published by Bernard Berenson in 1903 (revised and expanded editions, 1938 and 1961. The goal was to make Berenson’s catalog information—still an essential information resource today—available in a machine-readable format, allowing researchers to access the source content through open data services. This paper provides a technical overview of the methods and processes applied in the conversion of Berenson’s catalog to LOD using the CIDOC-CRM ontology; it also discusses the different phases of the project, focusing on the challenges and issues of data transformation and publishing. The project was funded by the Samuel H. Kress Foundation and organized by Villa I Tatti, The Harvard University Center for Italian Renaissance Studies. Catalog: http://florentinedrawings.itatti.harvard.edu Data Endpoint: http://data.itatti.harvard.edu

Islams gyldne alder

DEFF Research Database (Denmark)

Pedersen, Jens Olaf Pepke

2016-01-01

I stå. Forskningen i den arabisk-islamiske verden nåede sit højdepunkt mellem det ottende og 12. århundrede, men siden gik den i stå. En Harvard-økonom forsøger at kaste lys over årsagerne.......I stå. Forskningen i den arabisk-islamiske verden nåede sit højdepunkt mellem det ottende og 12. århundrede, men siden gik den i stå. En Harvard-økonom forsøger at kaste lys over årsagerne....

Japanese History, Post-Japan

Directory of Open Access Journals (Sweden)

George Lazopoulos

2014-03-01

Full Text Available Jason Ānanda Josephson, The Invention of Religion in Japan. Chicago, IL: University of Chicago Press, 2012. 408 pp. $90 (cloth, $30 (paper. Hwansoo Ilmee Kim, Empire of the Dharma: Korean and Japanese Buddhism, 1877–1912. Cambridge, MA: Harvard University Asia Center, 2012. 444 pp. $50 (cloth. Jung-Sun N. Han, An Imperial Path to Modernity: Yoshino Sakuzō and a New Liberal Order in East Asia, 1905–1937. Cambridge, MA: Harvard University Asia Center, 2012. 244 pp. $40 (cloth.

Mobile facilitation of science and technology awareness for preschool children

CSIR Research Space (South Africa)

Botha, Adèle

2009-09-01

Full Text Available on the Developing Child. They state that the quality of a child’s early environment and the availability of appropriate experiences at the right stages of development are crucial in determining the strength or weakness of the brain’s architecture, which, in turn... on the Developing Child. Available from: Center on the Developing Child at Harvard University. Web site: http://www.developingchild.harvard.edu. Traxler, J. (2007). Making Good Use of Mobile Phone Capabilities, 2nd International Conference on ICT for Development...

Higher Education Tarred with a Harvard Brush.

Science.gov (United States)

Trachtenberg, Stephen Joel

1987-01-01

The Secretary of Education Bennett and Michael Kinsley in an article in the Wall Street Journal claim that colleges are wasteful and ineffective, but the picture they paint of American higher education is essentially mythical. Higher education is seen as a scapegoat for politicians in an election year. (MLW)

Report on the R&D of Uranium Carbide targets by the PLOG collaboration at PNPI-Gatchina

CERN Document Server

A.E. Barzakh, D.V. Fedorov, A.M. Ionan, V.S. Ivanov, M.P. Levchenko, K.A. Mezilev, F.V. Moroz, S.Yu. Orlov, V.N. Panteleev, Yu.M. Volkov,O. Alyakrinskiy, A. Andrighetto, A. Lanchais, G. Lhersonneau*, V. Rizzi, L. Stroe#, L.B. Tecchio,O. Bajeat, M. Cheikh Mhamed, S. Essabaa, C. Lau, B. Roussière,M. Dubois, C. Eléon, G. Gaubert, P. Jardin, N. Lecesne, R. Leroy, J.Y. Pacquet, M. -G. Saint Laurent, A.C.C. Villari.

The aim of this report is to summarize the experimental results of the R&D program on Uranium Carbide targets for Radioactive Ion Beam (RIB) production performed at the Petersburg Nuclear Physics Institute (PNPI) of Gatchina (Russia). The targets have been irradiated with 1 GeV protons delivered by the Synchrocyclotron and the measurements were carried out at the IRIS isotope separator on-line. Different compositions of Uranium Carbide targets as well as different kinds of ion sources have been tested in order to evaluate efficiency and release times of the reaction products. The report includes the results of experiments performed in the period of time going from November 2001 up to March 2006. This R&D program was performed in the framework of the collaboration with the EURISOL, SPES and SPIRAL-2 projects and ISTC program.

People and things. CERN Courier, Jul-Aug 1989, v. 29(6)

International Nuclear Information System (INIS)

Anon.

1989-01-01

The article reports on achievements of various people, staff changes and position opportunities within the CERN organization and contains news updates on upcoming or past events. CERN's 600 MeV Synchro-Cyclotron (SC) is to make fluorine-18 for radiopharmaceuticals used to develop positron-emission tomography (PET) imaging techniques at Geneva's Cantonal Hospital. PET itself is a spinoff from particle physics ideas: CERN and the Geneva hospital closely collaborated in the development of the technique. At the Real-Time Conference at Williamsburg, Virginia, in May, Rene Brun of CERN's Data Handling Division was presented with the second CANPS Award attributed by the 'Computer Applications in Nuclear and Plasma Sciences' technical subcommittee of the Nuclear and Plasma Sciences Society of the IEEE for outstanding achievements in the applications of computers in nuclear and/or plasma sciences

The production of iodine-123 on the Harwell variable energy cyclotron

International Nuclear Information System (INIS)

Cuninghame, J.G.; Hill, J.I.S.; Nichols, A.L.; Taylor, N.K.

1978-01-01

123 I has often been called the isotope of choice for dynamic body function studies in nuclear medicine. There has therefore, been a keen interest in the possibility of regular supply of high purity 123 I produced by the Harwell Variable Energy Cyclotron (VEC) and Synchrocyclotron (SC). This report describes a three year research and development programme on the VEC which has resulted in a method for the safe and reliable large scale production of 123 I by irradiation of di-iodomethane with 58 MeV protons. The quality of the product, and the medical trials which have been carried out with it, are also discussed. The processing and handling of the hundreds of millicuries produced during a run presents serious handling problems. These have been solved and the methods and equipment developed are described. (author)

Golden Jubilee photos

CERN Multimedia

2004-01-01

Flash-back on 50 years of history. The SC, the first Machine In 1952, before CERN was officially founded, two accelerator projects were launched: one for an innovative accelerator to operate at an energy level unequalled at the time, the other for a more standard machine, a Synchro-Cyclotron (SC) to operate at 600 MeV. Design work on the SC was started in 1952 and carried out by teams scattered throughout Europe. Once construction began in 1954, CERN had to arrange road transport for the first of what has since been a long series of spectacular component deliveries, such as those of the machine's two magnetic coils each weighing 60 tonnes and measuring 7.2 metres in diameter. Above, one of them is seen passing through the village of Meyrin. The SC was commissioned in 1957 and was operational for 34 years!

The data acquisition system (DAS) for the improved CERN SC

CERN Document Server

Beger, H; Fiebig, A; Schroot, H

1975-01-01

A digital data acquisition system (DAS) based on a minicomputer is described which registers the failure sequences in various equipment areas of the CERN synchrocyclotron (henceforward referred to as the SC). The avalanches of failure signals which occur from time to time are tapped from the alarm/security systems, time-resolved to 10 msec and recorded on a printer in order to aid SC failure diagnosis. The mechanisms of the DAS and its relation to the SC equipment are explained in some detail. All programs were constructed at assembler language level for speed and for ease of on-line program maintenance. The alarm sequences recorded have been of considerable help during the running in of the new radiofrequency system. Now that the new SC is operational, the DAS furnishes useful data from several equipment areas to the operators and engineers.

The United Nuclear Research Institute

International Nuclear Information System (INIS)

Kiss, D.

1978-01-01

The UNRI, the only common institute of the socialist countries was founded in 1956 in Dubna. The scientists of small countries have the opportunity to take part in fundamental research with very expensive devices which are usually not available for them. There are six research laboratories and one department in the UNRI namely: the theoretical physical laboratory; the laboratory of high energies - there is a synchrophasotron of 1a GeV there; the laboratory of nuclear problems - there is a synchrocyclotron of 680 MeV there; the laboratory of nuclear reactions with the cyclotron U-300 which can accelerate heavy ions; the neutronphysical laboratory with the impulse reactor IBM-30; the laboratory of computation and automatization with two big computers; the department of new acceleration methods. The main results obtained by Hungarian scientist in Dubna are described. (V.N.)

Educational "Goodwill": Measuring the Intangible Assets at Highly Selective Private Colleges and Universities

OpenAIRE

Peter Nurnberg; Morton Schapiro; David Zimmerman

2011-01-01

In this paper we utilize data on the head-to-head loss rate for students accepted at Williams College, but who opt to enroll elsewhere. For example, we employ data that measure the fraction of students admitted to Williams and to Amherst (or Harvard or Yale, etc.) but who opt to attend Amherst (or Harvard or Yale, etc.) instead of Williams. We then model this head-to-head loss rate using data from a variety of sources. A better understanding of the head-to-head loss rate can assist an institu...

ISOLDE looks forward

International Nuclear Information System (INIS)

Anon.

1984-01-01

The original ISOLDE on-line isotope separator at the CERN 600 MeV Synchro-Cyclotron (SC) was commissioned in 1967 and worked successfully until being essentially rebuilt in 1973/74 at the same time as the SC was upgraded to give higher extracted intensities. Since then there have been continual improvements to practically every aspect of the facility, but two fundamental limitations appeared; the lack of running time for experiments and the lack of space to house those experiments. At the end of the 1970s and the early 1980s, ISOLDE-2 used close to 250 shifts per year but it became clear that this was the maximum the facility could handle. At about this time the CERN management decided the SC should become more and more an accelerator dedicated to ISOLDE experiments, with the aim of doubling the time allocation to 500 shifts per year

ISOLDE looks forward

Energy Technology Data Exchange (ETDEWEB)

Anon.

1984-11-15

The original ISOLDE on-line isotope separator at the CERN 600 MeV Synchro-Cyclotron (SC) was commissioned in 1967 and worked successfully until being essentially rebuilt in 1973/74 at the same time as the SC was upgraded to give higher extracted intensities. Since then there have been continual improvements to practically every aspect of the facility, but two fundamental limitations appeared; the lack of running time for experiments and the lack of space to house those experiments. At the end of the 1970s and the early 1980s, ISOLDE-2 used close to 250 shifts per year but it became clear that this was the maximum the facility could handle. At about this time the CERN management decided the SC should become more and more an accelerator dedicated to ISOLDE experiments, with the aim of doubling the time allocation to 500 shifts per year.

The history of CERN during the early 1950s

International Nuclear Information System (INIS)

Amaldi, E.

1989-01-01

This paper, written by CERN's first secretary general, looks at the history of CERN, the first example of an intergovernmental research laboratory created in Europe, which has now been operating successfully for more than thirty years. Three distinct periods of development are identified. Early initiatives sprang from a growing sense of European union, and a desire to gain the benefits of collaboration in scale, that United States examples such as Brookhaven National Laboratory had offered. The first big project was to build a 10GeV proton-synchrotron, at that time the largest in the world. The middle era corresponds to the establishment of the organization, with personnel assembling, and buildings and plant coming on line. In October 1954, with Felix Bloch as its director general, CERN entered its final permanent form. The synchrocyclotron operated in 1958 and a proton beam circulated in the proton-synchrotron in November 1959. (UK)

Franco Bonaudi 1928-2008

CERN Multimedia

2009-01-01

The famous photograph taken during the first interactions in the ISR in 1971. Kjell Johnsen speaks into the microphone. Franco Bonaudi can be seen on the far left. Franco Bonaudi, one of the true pioneers of CERN’s accelerators, passed away on 21 December 2008. In 1951, Franco Bonaudi was a young research engineer specialising in electronics and radiofrequency at the Politecnico di Torino, when he was invited by Edoardo Amaldi, one of the founders of CERN, to consider working for the provisional organisation that became known as CERN (European Organization for Nuclear Research). Accepting the challenge, he was sent to Liverpool in July 1952 to work with the study group led by Cornelius Bakker for the first CERN accelerator, the 600 MeV Synchrocyclotron (SC). After two years in Liverpool, he joined the rest of the newly appointed staff in the Geneva Airport hangar, where the future SC Divis...

Some reflections on the history of particle physics in the 1950s

International Nuclear Information System (INIS)

Schweber, S.S.

1989-01-01

This paper reflects on the differences in attitude, area of study and type of physicist between those attending the Solvay conferences in 1948 and 1961. These reflect wider historical and political changes which affected high-energy particle physics in the nineteen fifties. The growth of the field reflected post-war funding on a huge scale to ensure adequate scientific manpower for military purposes. Large synchrocyclotrons and proton-synchrotrons were built and high-energy installations became widespread in universities. Theoreticians worked closely with experimentalists using a pragmatic utilitarian approach. Later military needs began to dictate funding allocation and many theoreticians worked on military as well as their own projects. This pragmatic, group approach became accepted world-wide as the way to ''do'' big science. The funding system, including peer-review, tended only to reinforce the dominant view of theorists as valuable accessories of experimentalists. (UK)

The Chemistry Departement of the Institute for Nuclear Physics Research, Amsterdam, The Netherlands

International Nuclear Information System (INIS)

Lindner, L.

1977-01-01

In 1946, the Institute for Nuclear Physics Research (IKO) in Amsterdam was founded as a typical post World War II effort to cope with the surge in scientific research, primarily in the USA. At present, the Institute encompasses almost 250 workers - including a Philips research group - out of which nearly 30 are members of the Chemistry Department. In the beginning, the investigations dealt with more or less conventional tracerwork using long-lived radionuclides produced in nuclear reactors. This changed rapidly with the synchrocyclotron coming into operation in 1947. The present can be best characterized as a sort of a transition state. Emphasis has been laid upon more typical chemical aspects of the research program: a shift from ''nuclear'' chemistry to ''radio'' chemistry. The future is determined by the 500 MeV linear electron accelerator, dubbed MEA (Medium Energy Accelerator) already under construction. (T.G.)

The corporate practice of health care ... a panel discussion.

Science.gov (United States)

Calhoun, M J; Collins, M; Hasan, M; Klein, J I; Lundberg, G D; Mulligan, D H; Restuccia, R; Sapers, C M; Schram, R B; Woolhandler, S

1996-06-01

The pros and cons of treating health care as a profit-making business got a lively airing in Boston May 16, when the Harvard School of Public Health's "Second Conference on Strategic Alliances in the Evolving Health Care Market" presented what was billed as a "Socratic panel." The moderator was Charles R. Nesson, J.D., a Harvard Law School professor of 30 years' standing whose knack for guiding lively discussions is well known to viewers of such Public Broadcasting Service series as "The Constitution: That Delicate Balance. "As one panelist mentioned, Boston was an interesting place for this conversation. With a large and eminent medical establishment consisting mostly of traditionally not-for-profit institutions, the metropolis of the only state carried in 1972 by liberal Presidential candidate George McGovern is in one sense a skeptical holdout against the wave of aggressive investment capitalism that has been sweeping the health care industry since the 1994 failure of the Clinton health plan. In another sense, though, managed care-heavy Boston is an innovative crucible of change, just like its dominant HMO, the not-for-profit but merger-minded Harvard Pilgrim Health Care. Both of these facets of Beantown's health care psychology could be discerned in the comments heard during the panel discussion. With the permission of the Harvard School of Public Health--and asking due indulgence for the limitations of tape-recording technology in a room often buzzing with amateur comment--MANAGED CARE is pleased to present selections from the discussion in the hope that they will shed light on the business of health care.

Interview with James Bradner. Interviewed by Hannah Coaker.

Science.gov (United States)

Bradner, James E

2013-08-01

James E Bradner is an Assistant Professor in Medicine at Harvard Medical School (MA, USA) as well as a Staff Physician in the Division of Hematologic Malignancies at Dana-Farber Cancer Institute (MA, USA). The present research focus of the Bradner laboratory concerns the discovery and optimization of prototype drugs targeting cancer gene regulation. The clinical objective of the Bradner group is to deliver novel therapeutics for human clinical investigation in hematologic diseases. Bradner's awards and honors include the Damon Runyon-Rachleff Innovation Award, the Smith Family Award for Excellence in Biomedical Research, the Dunkin' Donuts Rising Star Award and the HMS Distinguished Excellence in Teaching Award. He is a member of the American Society of Clinical Investigation, the American Society of Hematology, the American Chemical Society and the American Association of Cancer Research. His recent research has been published in Nature, Cell, Nature Chemical Biology and the Journal of the American Chemical Society. He has authored more than 20 US Patent applications, licensed to five pharmaceutical companies, and is a scientific founder of Acetylon Pharmaceuticals, SHAPE Pharmaceuticals, Tensha Therapeutics and Syros Pharmaceuticals. Bradner received his AB from Harvard University, his MD from the University of Chicago (IL, USA) and a MMS from Harvard Medical School. He completed his postgraduate training in Internal Medicine at Brigham & Women's Hospital (MA, USA), followed by a fellowship in Medical Oncology and Hematology at Dana-Farber Cancer Institute. Following additional post-doctoral training in Chemistry at Harvard University and the Broad Institute (MA, USA) with Professor Stuart Schreiber, Bradner joined the research faculty of Dana-Farber in 2008. Interview conducted by Hannah Coaker, Assistant Commissioning Editor.

Budget projections - 1991 through 1996 for research in high energy physics

International Nuclear Information System (INIS)

1991-05-01

This research program in high energy physics is carried out under the general supervision of a committee which is composed of G.W. Brandenburg, G.J. Feldman, M.E. Franklin, R.J. Glauber, K. Kinoshita, F.M. Pipkin, K. Strauch, R. Wilson, and H. Yamamoto. Professor G.J. Feldman currently serves as chair of this committee. Dr. Brandenburg is the Director of the High Energy Physics Laboratory and administers the DOE high energy physics contract. In the fall of 1991 S. Mishra will join this committee. Harvard is planning to make one or two additional senior faculty appointments in experimental high energy physics over the next two years. The principal goals of the work described here are to carry out forefront programs in high energy physics research and to provide first rate educational opportunities for students. The experimental program supported through HEPL is carried out at the major accelerator centers in the world and addresses some of the most important questions in high energy physics. Harvard's educational efforts are concentrated in graduate education, where they are currently supporting thirteen research students. In addition, undergraduate students work in projects at HEPL during the academic year and over summers. These budget projections cover all of the Harvard based high energy physics experimental activities. The open-quotes umbrellaclose quotes nature of this contract greatly simplifies support of essential central technical and computer services and helps the group to take advantage of new physics opportunities and to respond to unexpected needs. The funding for the operation of the HEPL facility is shared proportionally by the experimental groups. Harvard financially supports this high energy physics research program in many ways

Training fellows in paediatric cardiology: the Harvard experience.

Science.gov (United States)

Brown, David W; Allan, Catherine K; Newburger, Jane W

2016-12-01

The Fellowship Program of the Department of Cardiology at Boston Children's Hospital seeks to train academically oriented leaders in clinical care and laboratory and clinical investigation of cardiovascular disease in the young. The core clinical fellowship involves 3 years in training, comprising 24 months of clinical rotations and 12 months of elective and research experience. Trainees have access to a vast array of research opportunities - clinical, basic, and translational. Clinical fellows interested in basic science may reverse the usual sequence and start their training in the laboratory, deferring clinical training for 1 or more years. An increasing number of clinical trainees apply to spend a fourth year as a senior fellow in one of the subspecialty areas of paediatric cardiology. From the founding of the Department to the present, we have maintained a fundamental and unwavering commitment to training and education in clinical care and research in basic science and clinical investigation, as well as to the training of outstanding young clinicians and investigators.

Harvard--MIT research program in short-lived radiopharmaceuticals

International Nuclear Information System (INIS)

1991-03-01

This report describes progress on five projects. The first project showed a 1000 fold concentration of the cationic complex 99m Tc (MIBI) in heart cell mitochondria vs heart cell cytoplasm, as determined by high resolution electron probe microanalysis. Additional technetium-99m based complexes are being developed and tested. The second project involves evaluating technetium acetylacteonates as potential indicators of cerebral blood flow. An intermediate in the synthesis of a technetium porphyrin complex has been synthesized; an oxotechnetium(V)-2,4-pentanedione complex has been prepared and is currently being characterized. The third project involves using radio labelled antibodies for diagnosis and treatment of cancer. An early discovery was that chloramine-T based iodination protocols resulted in a reversal of the charge on mouse lgGs. Immunoperoxidase-labelled monoclonal antibody MOv 18 was shown to bind specifically to the most frequent ovarian aderon carcinomas, and not to healthy tissue, making this antibody a good candidate for immunotherapy or immunodetection. Work on a specific immunotherapy protocol suffered a setback when one reagent, a 125 I-biotin complex, proved to be unstable in vivo. The fourth project involves labelling antibodies with positron emitting radionuclides. Radiofluorination was accomplished through reductive alkylation of 18 F-aldehyde, or pentafluorophenyl esters. Radioiodination was accomplished using alkyl-tin derivation exchange. The fifth project examined antibody modification for use in radioimmune imaging. Technetium-99m-labelled lgG was shown to be biologically equivalent to Indium-III-labelled lgG for imaging focal sites of inflamation. Also, Indium III labelling of small bioactive peptides was examined as a means of imaging important physiological processes. 44 refs., 2 figs

Early interventions and lessons from Harvard Business Review.

Science.gov (United States)

Chong, Siow-Ann

2007-11-01

To describe the establishment and development of an Early Psychosis Intervention Programme in Singapore that is based on a business model and with concepts drawn from the corporate world. The author who directed this programme describes the circumstances that led to this initiative, the ideas borrowed and adapted from the corporate world, and the lessons learnt in setting up this intervention programme. The modus operandi of the programme is based on the Balanced Scorecard - a model which stresses four equally important components: customers, internal processes, financial health and learning and innovation. Other complementary actions like creating a sense of urgency, forging a vision with a core ideology, empowerment of team members, creating short-term wins, anchoring the changes and finding meaning in the work are vital for the programme to thrive. This model also emphasizes the importance of accountability through the measurability of indicators. These indicators included a significant reduction in the duration of untreated psychosis, a positive change in the referral patterns with better engagement of the primary health-care sector and an improvement in the quality of care for the patients. Much can be learnt from the business world in building and maintaining a public mental health programme. Effective change also requires effective leadership, and the successful implementation of certain strategic steps.

Harvard-MIT research program in short-lived radiopharmaceuticals

Energy Technology Data Exchange (ETDEWEB)

Adelstein, S.J.

1991-01-01

This report presents research on radiopharmaceuticals. The following topics are discussed: antibody labeling with positron-emitting radionuclides; antibody modification for radioimmune imaging; labeling antibodies; evaluation of technetium acetlyacetonates as potential cerebral blood flow agents; and studies in technetium chemistry. (CBS)

Proton activation analysis at the Harvard Cyclotron Laboratory

International Nuclear Information System (INIS)

Sisterson, J.M.; Koehler, A.M.

1984-01-01

High-energy proton activation analysis (PAA), a simple non-destructive technique, has been developed for use as an adjunct to neutron activation analysis. Potential advantages of protons include the ability to achieve very precise localization of the activation volume over a pre-determined depth in the target. To demonstrate the versatility of PAA, results are reported on the measurement of the whole body calcium content in animals and on the determination of the Ca/P molar ratio in small quantities (<50 mg) of chemical and biological samples. The animal experiments demonstrate the ability to achieve a uniform irradiation over a large volume and utilizes large NaI crystals with a special chamber for uniform combined detection efficiency, where the Ca/P molar ratio determination requires a Ge/Li detector and analysis of the resulting gamma ray spectrum. The feasibility is being assessed of using proton beam activation of the eye to measure blood flow in the rabbit choroid, based on earlier work where it was used to measure blood in mouse skeletal tissue. 6 references, 7 figures, 4 tables

Joint Services Electronics Program (Harvard University. Cambridge, Massachusetts)

Science.gov (United States)

1988-09-30

34Band Structures of Semimagnetic Compounds," Acta Physica Polonica bf A73 (6), 933-941 (1988). (Partially supported by N00014-86-K-0760). c. Books...Journals K.L. Babcock and R.M. Westervelt, "Dynamics of Simple Electronic neural Net- works," Physica 28D, 305 (1987). C.M. Marcus and R.M. Westervelt

Strateegiaguru Porter, klastriguru Porter, sponsorlusguru Porter. Peaaegu, et gurude guru!

Index Scriptorium Estoniae

2005-01-01

Maailma juhtiva strateegiaguru, Harvard Business Schooli professori Michael Porteri seisukohtadest ja ideedest ettevõtete heategevuse, Interneti kui majandusharu ning klastrite kohta. Lisa: Michael Porter

"PhD Comics" author Jorge Cham on the power of procrastination

CERN Multimedia

Stefania Pandolfi

2015-01-01

From Tuesday, 22 to Friday, 25 September, Jorge Cham visited CERN. The PHD Movie 2 was screened in the Main Auditorium  and the cartoonist also took part in one of the Researchers' Night events.    Jorge Cham in the CERN Control Centre. On the first day, the author of the comic strip Piled Higher and Deeper (PhD Comics) visited the CERN Control Centre, the Synchrocyclotron, the CMS Service Cavern and the ATLAS control room. On Thursday, he had a busy afternoon, starting with signing copies of his books and then giving a talk entitled “The Power of Procrastination” in a packed Main Auditorium. He made the audience laugh by narrating his experience as a graduate student in robotics at Stanford University, recounting how he started drawing PhD Comics and how it rapidly became popular in universities all over the world. He then analysed the frustrations and anxieties commonly experienced by any graduate student, causing...

Frank Krienen (1917-2008)

CERN Multimedia

2008-01-01

Amsterdam, summer 1952: it was here that the first recruits for CERN ‘s 600 MeV Synchrocyclotron project met Frank Krienen for the first time. A young assistant to Prof. C.J. Bakker at the Physics Institute, he soon became the mastermind behind the most daring aspects of the project: the frequency modulating circuit, based on a vibrating tuning fork, was his creation. He was a respected and inspiring leader throughout the construction period of the accelerator and, at the same time, an older brother and an exacting mentor. Frank later devoted himself to developing particle detectors, in particular spark wire chambers using different types of readout. His next major involvement at CERN was his contribution to the glorious g-2 saga. Frank’s contributions to the last experiment of the anomalous magnetic moment of the muon (g-2) done at CERN (1969-1977) were very important in many aspects. The last (g-2) experiment was based on many...

Klaus Goebel - 1926-2009

CERN Multimedia

Horst Wenninger

Klaus Goebel, an early leading figure in radiation protection at CERN, passed away on 1 October 2009. Klaus came to CERN in 1956 together with Wolfgang Gentner for whom he had worked as an assistant from 1954-55, after gaining a diploma in economics and a doctorate in physics at the University of Freiburg, Germany. During these early years at the Laboratory, Klaus measured isotope concentrations in meteorites and as leader of the Spallation Research Group he used the Synchrocyclotron (SC) to measure isotope production by protons. This interest in trace measurements carried over to his work in CERN’s Health Physics Group, which he joined in 1962. He took over successively the radiation protection work at the SC and the Proton Synchrotron as section leader and became deputy group leader. In 1969-70 he spent a sabbatical as a health physicist at the Lawrence Radiation Laboratory in Berkeley, California. When Klaus came back to CERN the preparatory work for the construction of the Super Proton Sy...

Effect of nonaxial and hexadecapole deformation on the hyperfine splitting of energy levels in 238U muonic atoms

International Nuclear Information System (INIS)

Bagaev, V.I.; Mikhajlov, I.N.; Ortlepp, Kh.G.; Fromm, V.D.

1979-01-01

The effect of nonaxial and hexadecapole deformation on spectra of moun atoms is considered, the model of rigid nonaxial rotator being used. Experimental data on μ -238 U obtained on the JINR synchrocyclotron are presented. The effect of monopolar, quadrupolar and hexadecapolar parts of potential on muon spectrum is studied using a separated beam of negative 105 MeV/c muons, as the contribution of other harmonics is negligible. Wave functions of 238 U nucleus are determined in the framework of the Davydov-Filipov model. The values of charge distribution parameters obtained for 238 U are compared with available ones. The comparison shows that the effect of nuclear polarization on quadrupolar splitting of n→n-1 transitions decreases with the growth of n. Quadrupolar splitting of 4F→3D transitions is sufficiently large for experimental studies. Besides, vacuum polarization, radial charge distribution etc. produce an insignificant effect on the above transitions

Calculation of beam injection and modes of acceleration for the JINR phasotron

International Nuclear Information System (INIS)

Vorozhtsov, S.B.; Dmitrievsky, V.P.

1981-01-01

On the basis of computer simulation of particles motion from the injection region up to the final radius of the accelerated proton beam behaviour together with different modes of the JINR high current synchrocyclotron operation is investigated. The THOUR modified computer code is used for calculations. The calculations have been performed with allowance for particle radial-phase motion and particle axial motion and although with beam collective effects. Beam dynamics during first turns of particles has been considered by integrating equations of motion. Tolerances for magnetic field structure in the region of first phase oscillation are obtained. Verifications of time dependences of accelerated voltage amplitude are performed. Time dependences of beam intensity (with and without account for space charge effect) and of mean magnetic field disturbance and the dependence of the separatrice dimension on the orbit radius of the accelerated beam are given. The conclusion is drawn on the correctness of the earlier appreciation of beam intensity equaling 40-45 mkA

The Children of the Night need your help

CERN Multimedia

Antonella Del Rosso

2015-01-01

The “Children of the Night” is a colloquial name given to children suffering from Xeroderma pigmentosum (XP), a genetic disorder that causes extreme sensitivity to ultraviolet light. When affected individuals are exposed to the sun, their skin undergoes alterations that can quickly develop into cancer. Special equipment has been developed to protect them from UV exposure but it is uncomfortable and very expensive. The association THE Port has a project to help the children afflicted by the disorder and their families and is looking for experts who can contribute.   Visiting the Synchrocyclotron. Their homes are kept in darkness and they leave them only at nighttime. During the day they can’t go anywhere without a special suit that protects their skin and eyes from the sun’s rays. Mutant genes in their DNA impair their bodies’ capacity to repair and accurately replicate DNA damaged by UV light. This deficiency causes cancers to develo...

Maria and Giuseppe: lives intertwined with CERN’s history

CERN Multimedia

Pauline Gagnon

2014-01-01

CERN will be celebrating its 60th anniversary this year. That means 60 years of pioneering scientific research and exciting discoveries. Two Italian physicists, Maria and Giuseppe Fidecaro, remember nearly all of it since they arrived in 1956. Most impressively, they are still hard at work, every day!   Giuseppe and Maria Fidecaro in Restaurant No. 1, at CERN, in 2014, 60 years after they joined the Organization. The couple is easy to spot, even in the cafeteria during busy lunchtimes, where they usually engage in the liveliest discussions. “We argue quite a lot,” Maria tells me with a big smile. “We have very different styles.” “But in general, in the end, we agree,” completes Giuseppe. In October 1954, Giuseppe went to the University of Liverpool as a CERN Fellow to do research at its brand new synchrocyclotron. Maria also joined, having obtained a fellowship from the International Federation of University Women. After getting m...

Werner Albrecht (1924 - 2014)

CERN Multimedia

2014-01-01

Werner Albrecht, one of the very first mechanical designers recruited by CERN, passed away on 28 March. Born and educated in Zurich, where he spent the first years of his professional life, he joined CERN in June 1955.   Thanks to his experience and personality, he soon became the deputy to Frank Blythe, the head of the Synchrocyclotron (SC) technical office. The office, which included a large mechanical workshop, had been created in the light of the development and construction of the SC - the first of CERN’s accelerators. For around 25 years Werner kept this position at Frank’s side while the services under their responsibility evolved to become the natural facility to provide design and development for a large range of apparatus required by experimental physicists. After Frank’s retirement in 1980, Werner became head of the office, maintaining its typical character as an efficient, informal and friendly service. Omega, UA1, Aleph, Opal and Delphi are example...

Bruno Pontecorvo 1913-1993

International Nuclear Information System (INIS)

Anon.

1993-01-01

Academician Bruno Pontecorvo, one of the outstanding physicists of our times, died on 24 September 1993 at the age of 80. He was born on 22 August 1913 in Pisa, Italy. As a student he was noticed by Enrico Fermi and admitted to his world famous group in 1933, where he participated in the classical investigations of slow neutrons which paved the way for practical applications of nuclear power. In 1936 Pontecorvo joined Joliot- Curie's group in Paris, again participating in research which laid a foundation for modern nuclear physics, and making significant discoveries of his own. From 1940- 42 he worked in the USA, where he devised and introduced a neutron logging technique which is still used in oil prospecting. Then he worked in Canada, the UK (Harwell), and in 1950 moved to the Soviet Union, immediately joining the research at the world's then most powerful synchrocyclotron, which had just been put into operation at Dubna

Training course for eighteen teachers at CERN

CERN Multimedia

Laurianne Noemie Trimoulla

2015-01-01

From 8 to 10 December, 18 teachers from all over France attended a three-day training course on matter, organised by the LAMAP Foundation (Fondation La main à la pâte, see here) and hosted by CERN and S'Cool Lab. The LAMAP Foundation, set up by Georges Charpak in 1995, aims to help primary school teachers use the investigative process to instil the scientific spirit in their pupils.      Fired by curiosity and eager to learn, the teachers were introduced to the many and varied activities on offer at CERN, including the cloud chamber experiment, the Masterclass programme and the "Be a physicist" learning scheme. They particularly enjoyed their tours of Microcosm, the Synchrocyclotron and the ATLAS visitor centre, which stimulated many questions. They are eagerly looking forward to passing on their newly found knowledge to their pupils and perhaps even inspiring some to take up a career in physics! Last but not least, they were treat...

Annual report 1975

International Nuclear Information System (INIS)

1976-01-01

The progress report is divided into two parts, for Laboratory I (basic and ISR programmes) and Laboratory II (300-GeV accelerator programme) respectively. In the first part, a general survey is given of the research results achieved in 1975 with the 28-GeV Proton Synchrotron and the Intersecting Storage Rings, as well as of corresponding theoretical and technological developments. More detailed accounts are given under Departmental and Divisional headings - Nuclear Physics, Synchrocyclotron Machine, Track Chambers, Theoretical Studies, Proton Synchrotron Machine, Data Handling, Intersecting Storage Rings, Finance, Personnel, Technical Services and Buildings, Health and Safety, and Central Services. The second part of the report describes the progress with the construction of the 300-400-GeV Super Proton Synchrotron. Organigrams of the Council and the two Laboratories, as well as a brief account of CERN's history, are included. Appendices provide a bibliography of CERN publications in 1975 and lists of lectures and seminars, training programmes, and scientific conferences and schools organized during the year. (AGH/AJ)

Literature in focus: The history of radioactivity

CERN Document Server

2006-01-01

René Bimbot, an expert in nuclear physics, will be coming to present his book - The History of Radioactivity. The work provides a summary of our accumulated knowledge of radioactivity and its applications, from its discovery to the present day. Presented in layman's terms, and backed by plenty of illustrations, the work creates the link between the rudimentary knowledge available in the times of Becquerel and the Curies and contemporary physics. It takes us on a great physics adventure, from the nucleus to the quark, from artificial radioactivity to radiotherapy, from the discovery of fission to nuclear reactors, not forgetting dating methods. Finally, the work provides a wealth of practical information on radiation and on matters relating to nuclear waste. A former Research Director at the CNRS, a heavy-ion physicist at the Orsay Nuclear Physics Institute, René Bimbot is no stranger to CERN. At the beginning of the 1980s, he worked on the CERN Synchrocyclotron, before joining the GANIL experiment in 1985...

Who lost the health care revolution?

Science.gov (United States)

Curry, W

1990-01-01

Just a year ago, in the March-April 1989 issue of Harvard Business Review, Professor Regina E. Herzlinger of the Harvard Business School took a long look at the U.S. health care system and declared the much touted revolution in the health care delivery system a failure. This article is a summary of the arguments that Professor Herzlinger marshaled for her treatise. In the following two articles, members of the College assess those arguments in terms of the medical management profession and in terms of the organizations, a hospital and a managed care company, for which they work. Finally, Professor Herzlinger returns to the subject with a response to these physician executives.

Sociological-Dysfunctionality(SD) Tyrrany-of-Arrogance((ToA) Versus (So Miscalled) "Wisdom-of-Crowds" Fascism; Jargonial-Obfuscation(JO) Egocentrism Enabling Would Be "Sciences" to be Alas Mere SEANCES!!!.

Science.gov (United States)

Bradshaw, John; Martin, Brian; Carl-Ludwig Siegel, Edward; Euclid, Alexandria; Young, Frederic; Clay, London

2013-03-01

The effort to get more women to continue in physics is ongoing and many hypotheses exist as to why the gender ratio lags more in physics than in other fields. A historical investigation can offer insights to the origin of this persistent problem. Radcliffe College offered to female students an education supposedly equivalent to that offered to male students at Harvard. I track physics classes at Radcliffe and Harvard from Radcliffe's charter year to the year the physics classes fully merged. Data on instructors, enrollment, and later employment offers insights to trends in physics education over time and how the genders were affected differently even when multiple variables are isolated across the two single-gender groups.

Acromegaly said to respond to proton therapy

International Nuclear Information System (INIS)

Raymond, C.A.

1988-01-01

A news article is presented which discusses a new use for proton therapy. As physicians and physicists continue to refine the clinical applications for charged particles, they can point to at least one notable success story: the treatment of acromegaly, a disorder that afflicts an estimated 250 persons in the United States each year. Bernard Kliman, MD, reported at the annual Endocrine Society meeting in Indianapolis that his group at Harvard Medical School, Boston, and the Harvard cyclotron has cured 479 (85.5%) of 560 patients with acromegaly or gigantism. Cure is defined as reducing growth hormone level to less than 5 μg/L and shrinking the soft tissue growth characteristic of the disease

Acromegaly said to respond to proton therapy

Energy Technology Data Exchange (ETDEWEB)

Raymond, C.A.

1988-02-12

A news article is presented which discusses a new use for proton therapy. As physicians and physicists continue to refine the clinical applications for charged particles, they can point to at least one notable success story: the treatment of acromegaly, a disorder that afflicts an estimated 250 persons in the United States each year. Bernard Kliman, MD, reported at the annual Endocrine Society meeting in Indianapolis that his group at Harvard Medical School, Boston, and the Harvard cyclotron has cured 479 (85.5%) of 560 patients with acromegaly or gigantism. Cure is defined as reducing growth hormone level to less than 5 ..mu..g/L and shrinking the soft tissue growth characteristic of the disease.

75 FR 9006 - President's Council of Advisors on Science and Technology; Notice of Meeting: Partially Closed...

Science.gov (United States)

2010-02-26

.... Varmus, President, Memorial Sloan-Kettering Cancer Center; and Dr. Eric S. Lander, President and Director, Broad Institute of MIT and Harvard. Meeting Accomodations: Individuals requiring special accommodation...

Resenha de: Business History Review

Directory of Open Access Journals (Sweden)

José Sebastião Witter

1966-09-01

Full Text Available BUSINESS HISTORY REVIEW. — Published quaterly by The Harvard Graduate School of Business Administration. Volume XXXIX, number 4. Winter 1965. Soldiers Field, Boston, Massachussets.

Two different formulations of the heavy quark effective theory

International Nuclear Information System (INIS)

Balk, S.; Ilakovac, A.; Koerner, J.G.; Pirjol, D.

1994-01-01

We point out that there exist two different formulations of the Heavy Quark Effective Theory (HQET). The one formulation of HQET was mostly developed at Harvard and involves the use of the equation of motion to eliminate the small components of the heavy quark field. The second formulation, developed in Mainz, involves a series of Foldy-Wouthuysen-type field transformations which diagonalizes the heavy quark Lagrangian in terms of an effective quark and antiquark sector. Starting at O(1/m Q 2 ) the two formulations are different in that their effective Lagrangians, their effective currents, and their effective wave functions differ. However, when these three differences are properly taken into account, the two alternative formulations lead to identical transition or S-matrix elements. This is demonstrated in an explicit example at O(1/m Q 2 ). We point to an essential difficulty of the Harvard HQET in that the Harvard effective fields are not properly normalized starting at order O(1/m Q 2 ). We provide explicit higher order expressions for the effective fields and the Lagrangian in the Mainz approach, and write down an O(1/m Q 2 ) nonabelian version of the Pauli equation for the heavy quark effective field. (orig.)

Community‐Based Participatory Research Skills and Training Needs in a Sample of Academic Researchers from a Clinical and Translational Science Center in the Northeast

Science.gov (United States)

DiGirolamo, Ann; Geller, Alan C.; Tendulkar, Shalini A.; Patil, Pratima; Hacker, Karen

2012-01-01

Abstract Purpose: To determine the community‐based participatory research (CBPR) training interests and needs of researchers interested in CBPR to inform efforts to build infrastructure for conducting community‐engaged research. Method: A 20‐item survey was completed by 127 academic health researchers at Harvard Medical School, Harvard School of Public Health, and Harvard affiliated hospitals. Results: Slightly more than half of the participants reported current or prior experience with CBPR (58 %). Across all levels of academic involvement, approximately half of the participants with CBPR experience reported lacking skills in research methods and dissemination, with even fewer reporting skills in training of community partners. Regardless of prior CBPR experience, about half of the respondents reported having training needs in funding, partnership development, evaluation, and dissemination of CBPR projects. Among those with CBPR experience, more than one‐third of the participants wanted a mentor in CBPR; however only 19 % were willing to act as a mentor. Conclusions: Despite having experience with CBPR, many respondents did not have the comprehensive package of CBPR skills, reporting a need for training in a variety of CBPR skill sets. Further, the apparent mismatch between the need for mentors and availability in this sample suggests an important area for development. Clin Trans Sci 2012; Volume #: 1–5 PMID:22686211

Medications (for IBS)

Medline Plus

Full Text Available ... Anthony J. Lembo, MD, Instructor of Medicine, Harvard Medical School; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA. Last modified on February 23, ...

Leadership and Administrative Skills for Optimal Universal Basic ...

African Journals Online (AJOL)

DR Nneka

dimensional and contingency theories respectively. ... understanding of the concept, Peretomode's (2003) views of leadership is .... People-Oriented – Administration, whether in small or large organizations is ..... Harvard Business Review.

A pedagogical approach to socially just relations in a Grade 11 ...

African Journals Online (AJOL)

zayd

namely sustainable development, equity (including equality) and economic development, ... working towards education for social justice in an Economics Grade 11 classroom is a ...... Mansfield, OH: Book Masters. ... Harvard University Press.

03 Inkanyiso Onyancha.fm

African Journals Online (AJOL)

user

American Society for Information Science), newspapers, and books as well as on the Internet. Publications count ... economic rate of return, case studies, retrospective analysis or questionnaire surveys? ...... Harvard: Analytic Technologies.

An Investigation on the Rate of Crime in Sokoto State Using ...

African Journals Online (AJOL)

natural vegetation, location and socio-economic characteristics has .... between crime and socio-economic status in Ottawa and Saskatoon, the ..... Ibadan: Spectrum Books Limited. Exp (2008). ... Cambridge, MA.: Harvard University press,:.

75 FR 22635 - President's Council of Advisors on Science and Technology; Meeting

Science.gov (United States)

2010-04-29

... President, The White House; Dr. Harold E. Varmus, President, Memorial Sloan-Kettering Cancer Center; and Dr. Eric S. Lander, President and Director, Broad Institute of MIT and Harvard. Meeting Accomodations...

Hotel shows health system keys to service excellence.

Science.gov (United States)

2003-08-01

Ritz-Carlton partnership part of broader program pursuing service excellence. Nearly 600 system leaders will participate in day-long seminars. GE, Harvard serve as strategic partners for ongoing educational efforts.

Human Cloning

National Research Council Canada - National Science Library

Johnson, Judith A; Williams, Erin D

2006-01-01

.... Scientists in other labs, including Harvard University and the University of California at San Francisco, intend to produce cloned human embryos in order to derive stem cells for medical research...

Footprint of Sandia's August 15 2016 Informal Idea Exploration Session on "Towards an Engineering and Applied Science of Research".

Energy Technology Data Exchange (ETDEWEB)

Tsao, Jeffrey Y. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Fleming Lindsley, Elizabeth S. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Heffelfinger, Grant S. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Narayanamurti, Venkatesh [Harvard Univ., Cambridge, MA (United States); Schneider, Rick [glo USA, Sunnyvale, CA (United States); Starkweather, Lynne M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ting, Christina [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Yajima, Rieko [Stanford Univ., CA (United States); Bauer, Travis L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Coltrin, Michael E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Guy, Donald W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Wendell [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Mareda, John F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Nenoff, Tina M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Turnley, Jessica Glicken [Galisteo Consulting Group, Albuquerque, NM (United States)

2017-02-01

On August 15, 2016, Sandia hosted a visit by Professor Venkatesh Narayanamurti. Prof Narayanamurti (Benjamin Peirce Research Professor of Technology and Public Policy at Harvard, Board Member of the Belfer Center for Science and International Affairs, former Dean of the School of Engineering and Applied Science at Harvard, former Dean of Engineering at UC Santa Barbara, and former Vice President of Division 1000 at Sandia). During the visit, a small, informal, all-day idea exploration session on "Towards an Engineering and Applied Science of Research" was conducted. This document is a brief synopsis or "footprint" of the presentations and discussions at this Idea Exploration Session. The intent of this document is to stimulate further discussion about pathways Sandia can take to improve its Research practices.

OBJEKTIVNOST REGULACIJSKIH TESTOVA (HARVARDSKI STEP-TEST U PROCENI STANJA FIZIČKE PRIPREMLJENOSTI MLADIH SPORTISTA

Directory of Open Access Journals (Sweden)

Goran Šekeljić

2005-05-01

Full Text Available The need of estimation of one of the phisical characteristics of men (the aerobic capacity led to the appearance of the first test (Harvard step-test in 1943. and consequently to the appearance of the first instrument for testing functional abilities (step-bench. Despite the subsequente appearance of the step-bench – it is simple, economic and available to wide-spread use – have favourized step-test as test of choise, and in certain circumstance they are the only possible test. The aim of this research has been to check and possibly improve standardization of the Harvard step-test. A sample of 64 male athletes aged 15 to 17 has been chosen. Statiscally signifant in the estimation of maximum oxygen uptake have been fond

Memória digital e o futuro da comunicação: entrevista com Robert Darnton

Directory of Open Access Journals (Sweden)

Aline Strelow

2013-06-01

Full Text Available Robert Darnton é diretor da Biblioteca da Universidade Harvard e referência internacional nos estudos de história da comunicação e história cultural. Dirige também, atualmente, a Digital Public Library of America, biblioteca digital lançada em abril de 2013, que reúne acervos de bibliotecas, arquivos e museus. Autor de dezenas de livros, nesta entrevista, ele fala sobre o desenvolvimento da DPLA, sobre os desafios enfrentados pelos projetos de digitalização, sobre o futuro do livro, do jornalismo e da pesquisa em história da comunicação diante das novas tecnologias. A entrevista foi realizada em outubro de 2012, no escritório do autor na Universidade Harvard.

The Responsibility to Protect: Report of the International ...

International Development Research Centre (IDRC) Digital Library (Canada)

Book cover The Responsibility to Protect: Report of the International Commission ... for Human Rights Policy, Kennedy School of Government, Harvard University. ... (1987-1999) and Switzerland's State Secretary for External Economic Affairs.

Know Stroke: Know the Signs, Act in Time Video

Medline Plus

Full Text Available ... sickle cell disease, high cholesterol, or a family history of stroke. Dr. Galen Henderson, Harvard Medical School, Brigham and Women's Hospital: "Strokes are preventable, they can be prevented, ...

R-ES-ONAN--CEI

Indian Academy of Sciences (India)

... assigned to work at the Bureau of Ordinance Computation Project at Harvard ... Programming this electro-mechanical relay computer was laborious as there was ... massive investments and rapid developments of information technology.

Research Paper Reliability of self report questionnaires for ...

African Journals Online (AJOL)

The scales used were: the Short Mood and Feelings Questionnaire (SMFQ), Zung Self-rating Anxiety Scale (SAS), Self-esteem Questionnaire (SEQ), Harvard ... (HTQ) and Multi-Dimensional Scale of Perceived Social Support (MSPSS).

The 2006 Lebanon Campaign and the Future of Warfare: Implications for Army and Defense Policy

National Research Council Canada - National Science Library

Biddle, Stephen; Friedman, Jeffrey A

2008-01-01

.... Stephen Biddle of the Council on Foreign Relations and Mr. Jeffrey Friedman, Harvard Kennedy School of Government, seeks to inform this debate by examining in detail Hezbollah's conduct of the 2006 campaign...

TOWARDS RELEVANT THEOLOGICAL EDUCATION IN AFRICA ...

African Journals Online (AJOL)

political and social-economic problems in Africa; a challenge theological education needs to ... current scholarship but are actively contributing to it through books, journals and higher ...... Cambridge: Harvard University. BAnks, r. 1999.

AFRICAN JOURNAL OF ECONOMIC REVIEW

African Journals Online (AJOL)

Dr Kazungu

SME Credit Financing, Financial Development and Economic Growth in Nigeria. Alimi, Y. Olorunfemi1 and ..... Economic Backwardness in Historical Perspective: A Book of Essays. Cambridge, Mass: Harvard University Press. Hicks, J. (1969).

(2013) VOL. 1 ISSUE 1 On behalf of our Editorial Board, I am ...

African Journals Online (AJOL)

OLAWUYI

journal features research articles, book reviews and commentaries on matters of ... or nothing to show in terms of development, economic prosperity, social stability and ... Glasgow, Hull, Harvard, Oxford, Calgary, Liverpool, British Columbia,.

Fostering Corporate Entrepreneurship

African Journals Online (AJOL)

The global. economy is no doubt creating profound and substantial changes for .... book outlined guidelines and recommendations for people inside organizations to bring forth and ..... Innovation, Harvard Business School Press, Boston. 34.

Download this PDF file

African Journals Online (AJOL)

development and agricultural extension was the focus of this study. .... Harvard Analytical Framework or Gender Roles Framework. ...... C Overholt Gender Analysis in Development Planning: A Case. Book. West Hartford, CT: Kumarian Press.

Operational Ocean Modelling with the Harvard Ocean Prediction System

Science.gov (United States)

2008-11-01

tno.nl TNO-rapportnummer TNO-DV2008 A417 Opdrachtnummer Datum november 2008 Auteur (s) dr. F.P.A. Lam dr. ir. M.W. Schouten dr. L.A. te Raa...area of theory and implementation of numerical schemes and parameterizations, ocean models have grown from experimental tools to full-blown ocean...sound propagation through mesoscale features using 3-D coupled mode theory , Thesis, Naval Postgraduate School, Monterey, USA. 1992. [9] Robinson

Global Oncology; Harvard Global Health Catalyst summit lecture notes

Science.gov (United States)

Ngwa, Wilfred; Nguyen, Paul

2017-08-01

The material presented in this book is at the cutting-edge of global oncology and provides highly illuminating examples, addresses frequently asked questions, and provides information and a reference for future work in global oncology care, research, education, and outreach.

Influence of Students’ Mental and Physical Performance on Development of Technical and Tactical Skills in Fencing

Directory of Open Access Journals (Sweden)

І. В. Кривенцова

2016-04-01

Full Text Available Study objective: to reveal the relations between the indicators of physical and mental performance and the development of technical and tactical skills in fencers, to determine the significant criteria and tests for selecting students for health-improving and sports fencing groups. Methods: study and analysis of literature; pedagogical observations; physiological methods (physical performance by the Harvard step test with HSTI (Harvard step test Index calculation, mental performance by the correction tables, special exercises to assess fencers’ technical and tactical skills; statistical methods. The reference group students (9 female fencers had five workouts a week, the students (13 female students of test group 1 (TG1 had 2 hours of physical training per week, the TG2 and TG3  (8 and 10 female students respectively had 4 hours of fencing workouts per week. The TG2 had 4 months of fencing experience, and TG3 had one year and 4 months thereof. Results. The reciprocal effects of the performance indicators and the correlation between the indicators of technical and tactical skills of the student fencers allowed to establish the informative value of individual indicators for quality selection of students for the fencing group. The Harvard step test index and the standardized number of errors of the correction test can serve as the prognostic criteria for developing technical and tactical skills in student fencing.

Causal inference as an emerging statistical approach in neurology: an example for epilepsy in the elderly

Directory of Open Access Journals (Sweden)

Moura LMVR

2016-12-01

Full Text Available Lidia MVR Moura,1,2 M Brandon Westover,1,2 David Kwasnik,1 Andrew J Cole,1,2 John Hsu3–5 1Massachusetts General Hospital, Department of Neurology, Epilepsy Service, Boston, MA, USA; 2Harvard Medical School, Boston, MA, USA; 3Massachusetts General Hospital, Mongan Institute, Boston, MA, USA; 4Harvard Medical School, Department of Medicine, Boston, MA, USA; 5Harvard Medical School, Department of Health Care Policy, Boston, MA, USA Abstract: The elderly population faces an increasing number of cases of chronic neurological conditions, such as epilepsy and Alzheimer’s disease. Because the elderly with epilepsy are commonly excluded from randomized controlled clinical trials, there are few rigorous studies to guide clinical practice. When the elderly are eligible for trials, they either rarely participate or frequently have poor adherence to therapy, thus limiting both generalizability and validity. In contrast, large observational data sets are increasingly available, but are susceptible to bias when using common analytic approaches. Recent developments in causal inference-analytic approaches also introduce the possibility of emulating randomized controlled trials to yield valid estimates. We provide a practical example of the application of the principles of causal inference to a large observational data set of patients with epilepsy. This review also provides a framework for comparative-effectiveness research in chronic neurological conditions. Keywords: epilepsy, epidemiology, neurostatistics, causal inference