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Sample records for harness test based

  1. Automation of Electrical Cable Harnesses Testing

    Directory of Open Access Journals (Sweden)

    Zhuming Bi

    2017-12-01

    Full Text Available Traditional automated systems, such as industrial robots, are applied in well-structured environments, and many automated systems have a limited adaptability to deal with complexity and uncertainty; therefore, the applications of industrial robots in small- and medium-sized enterprises (SMEs are very limited. The majority of manual operations in SMEs are too complicated for automation. The rapidly developed information technologies (IT has brought new opportunities for the automation of manufacturing and assembly processes in the ill-structured environments. Note that an automation solution should be designed to meet the given requirements of the specified application, and it differs from one application to another. In this paper, we look into the feasibility of automated testing for electric cable harnesses, and our focus is on some of the generic strategies for the improvement of the adaptability of automation solutions. Especially, the concept of modularization is adopted in developing hardware and software to maximize system adaptability in testing a wide scope of products. A proposed system has been implemented, and the system performances have been evaluated by executing tests on actual products. The testing experiments have shown that the automated system outperformed manual operations greatly in terms of cost-saving, productivity and reliability. Due to the potential of increasing system adaptability and cost reduction, the presented work has its theoretical and practical significance for an extension for other automation solutions in SMEs.

  2. Developing a TTCN-3 Test Harness for Legacy Software

    DEFF Research Database (Denmark)

    Okika, Joseph C.; Ravn, Anders Peter; Siddalingaiah, Lokesh

    2006-01-01

    We describe a prototype test harness for an embedded system which is the control software for a modern marine diesel engine. The operations of such control software requires complete certification. We adopt Testing and Test Control Notation (TTCN-3) to define test cases for this purpose. The main...... challenge in developing the test harness is to interface a generic test driver to the legacy software and provide a suitable interface for test engineers. The main contribution of this paper is a demonstration of a suitable design for such a test harness. It includes: a TTCN-3 test driver in C++, the legacy...

  3. A test harness for accelerating physics parameterization advancements into operations

    Science.gov (United States)

    Firl, G. J.; Bernardet, L.; Harrold, M.; Henderson, J.; Wolff, J.; Zhang, M.

    2017-12-01

    The process of transitioning advances in parameterization of sub-grid scale processes from initial idea to implementation is often much quicker than the transition from implementation to use in an operational setting. After all, considerable work must be undertaken by operational centers to fully test, evaluate, and implement new physics. The process is complicated by the scarcity of like-to-like comparisons, availability of HPC resources, and the ``tuning problem" whereby advances in physics schemes are difficult to properly evaluate without first undertaking the expensive and time-consuming process of tuning to other schemes within a suite. To address this process shortcoming, the Global Model TestBed (GMTB), supported by the NWS NGGPS project and undertaken by the Developmental Testbed Center, has developed a physics test harness. It implements the concept of hierarchical testing, where the same code can be tested in model configurations of varying complexity from single column models (SCM) to fully coupled, cycled global simulations. Developers and users may choose at which level of complexity to engage. Several components of the physics test harness have been implemented, including a SCM and an end-to-end workflow that expands upon the one used at NOAA/EMC to run the GFS operationally, although the testbed components will necessarily morph to coincide with changes to the operational configuration (FV3-GFS). A standard, relatively user-friendly interface known as the Interoperable Physics Driver (IPD) is available for physics developers to connect their codes. This prerequisite exercise allows access to the testbed tools and removes a technical hurdle for potential inclusion into the Common Community Physics Package (CCPP). The testbed offers users the opportunity to conduct like-to-like comparisons between the operational physics suite and new development as well as among multiple developments. GMTB staff have demonstrated use of the testbed through a

  4. Albumin-based drug delivery: harnessing nature to cure disease.

    Science.gov (United States)

    Larsen, Maja Thim; Kuhlmann, Matthias; Hvam, Michael Lykke; Howard, Kenneth A

    2016-01-01

    The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand binding sites, cellular receptor engagement, and a long circulatory half-life due to interaction with the recycling neonatal Fc receptor. Exploitation of these properties promotes albumin as an attractive candidate for half-life extension and targeted intracellular delivery of drugs attached by covalent conjugation, genetic fusions, association or ligand-mediated association. This review will give an overview of albumin-based products with focus on the natural biological properties and molecular interactions that can be harnessed for the design of a next-generation drug delivery platform.

  5. Harnessing scientific literature reports for pharmacovigilance. Prototype software analytical tool development and usability testing.

    Science.gov (United States)

    Sorbello, Alfred; Ripple, Anna; Tonning, Joseph; Munoz, Monica; Hasan, Rashedul; Ly, Thomas; Francis, Henry; Bodenreider, Olivier

    2017-03-22

    We seek to develop a prototype software analytical tool to augment FDA regulatory reviewers' capacity to harness scientific literature reports in PubMed/MEDLINE for pharmacovigilance and adverse drug event (ADE) safety signal detection. We also aim to gather feedback through usability testing to assess design, performance, and user satisfaction with the tool. A prototype, open source, web-based, software analytical tool generated statistical disproportionality data mining signal scores and dynamic visual analytics for ADE safety signal detection and management. We leveraged Medical Subject Heading (MeSH) indexing terms assigned to published citations in PubMed/MEDLINE to generate candidate drug-adverse event pairs for quantitative data mining. Six FDA regulatory reviewers participated in usability testing by employing the tool as part of their ongoing real-life pharmacovigilance activities to provide subjective feedback on its practical impact, added value, and fitness for use. All usability test participants cited the tool's ease of learning, ease of use, and generation of quantitative ADE safety signals, some of which corresponded to known established adverse drug reactions. Potential concerns included the comparability of the tool's automated literature search relative to a manual 'all fields' PubMed search, missing drugs and adverse event terms, interpretation of signal scores, and integration with existing computer-based analytical tools. Usability testing demonstrated that this novel tool can automate the detection of ADE safety signals from published literature reports. Various mitigation strategies are described to foster improvements in design, productivity, and end user satisfaction.

  6. Determining Damping Trends from a Range of Cable Harness Assemblies on a Launch Vehicle Panel from Test Measurements

    Science.gov (United States)

    Smith, Andrew; Davis, R. Ben; LaVerde, Bruce; Jones, Douglas

    2012-01-01

    The team of authors at Marshall Space Flight Center (MSFC) has been investigating estimating techniques for the vibration response of launch vehicle panels excited by acoustics and/or aero-fluctuating pressures. Validation of the approaches used to estimate these environments based on ground tests of flight like hardware is of major importance to new vehicle programs. The team at MSFC has recently expanded upon the first series of ground test cases completed in December 2010. The follow on tests recently completed are intended to illustrate differences in damping that might be expected when cable harnesses are added to the configurations under test. This validation study examines the effect on vibroacoustic response resulting from the installation of cable bundles on a curved orthogrid panel. Of interest is the level of damping provided by the installation of the cable bundles and whether this damping could be potentially leveraged in launch vehicle design. The results of this test are compared with baseline acoustic response tests without cables. Damping estimates from the measured response data are made using a new software tool that employs a finite element model (FEM) of the panel in conjunction with advanced optimization techniques. This paper will report on the \\damping trend differences. observed from response measurements for several different configurations of cable harnesses. The data should assist vibroacoustics engineers to make more informed damping assumptions when calculating vibration response estimates when using model based analysis approach. Achieving conservative estimates that have more flight like accuracy is desired. The paper may also assist analysts in determining how ground test data may relate to expected flight response levels. Empirical response estimates may also need to be adjusted if the measured response used as an input to the study came from a test article without flight like cable harnesses.

  7. Automatic recognition of falls in gait-slip training: Harness load cell based criteria.

    Science.gov (United States)

    Yang, Feng; Pai, Yi-Chung

    2011-08-11

    Over-head-harness systems, equipped with load cell sensors, are essential to the participants' safety and to the outcome assessment in perturbation training. The purpose of this study was to first develop an automatic outcome recognition criterion among young adults for gait-slip training and then verify such criterion among older adults. Each of 39 young and 71 older subjects, all protected by safety harness, experienced 8 unannounced, repeated slips, while walking on a 7m walkway. Each trial was monitored with a motion capture system, bilateral ground reaction force (GRF), harness force, and video recording. The fall trials were first unambiguously indentified with careful visual inspection of all video records. The recoveries without balance loss (in which subjects' trailing foot landed anteriorly to the slipping foot) were also first fully recognized from motion and GRF analyses. These analyses then set the gold standard for the outcome recognition with load cell measurements. Logistic regression analyses based on young subjects' data revealed that the peak load cell force was the best predictor of falls (with 100% accuracy) at the threshold of 30% body weight. On the other hand, the peak moving average force of load cell across 1s period, was the best predictor (with 100% accuracy) separating recoveries with backward balance loss (in which the recovery step landed posterior to slipping foot) from harness assistance at the threshold of 4.5% body weight. These threshold values were fully verified using the data from older adults (100% accuracy in recognizing falls). Because of the increasing popularity in the perturbation training coupling with the protective over-head-harness system, this new criterion could have far reaching implications in automatic outcome recognition during the movement therapy. Copyright © 2011 Elsevier Ltd. All rights reserved.

  8. AUTOMATIC RECOGNITION OF FALLS IN GAIT-SLIP: A HARNESS LOAD CELL BASED CRITERION

    Science.gov (United States)

    Yang, Feng; Pai, Yi-Chung

    2012-01-01

    Over-head-harness systems, equipped with load cell sensors, are essential to the participants’ safety and to the outcome assessment in perturbation training. The purpose of this study was to first develop an automatic outcome recognition criterion among young adults for gait-slip training and then verify such criterion among older adults. Each of 39 young and 71 older subjects, all protected by safety harness, experienced 8 unannounced, repeated slips, while walking on a 7-m walkway. Each trial was monitored with a motion capture system, bilateral ground reaction force (GRF), harness force and video recording. The fall trials were first unambiguously indentified with careful visual inspection of all video records. The recoveries without balance loss (in which subjects’ trailing foot landed anteriorly to the slipping foot) were also first fully recognized from motion and GRF analyses. These analyses then set the gold standard for the outcome recognition with load cell measurements. Logistic regression analyses based on young subjects’ data revealed that peak load cell force was the best predictor of falls (with 100% accuracy) at the threshold of 30% body weight. On the other hand, the peak moving average force of load cell across 1-s period, was the best predictor (with 100% accuracy) separating recoveries with backward balance loss (in which the recovery step landed posterior to slipping foot) from harness assistance at the threshold of 4.5% body weight. These threshold values were fully verified using the data from older adults (100% accuracy in recognizing falls). Because of the increasing popularity in the perturbation training coupling with the protective over-head-harness system, this new criterion could have far reaching implications in automatic outcome recognition during the movement therapy. PMID:21696744

  9. Harnessing complexity: taking advantage of context and relationships in dissemination of school-based interventions.

    Science.gov (United States)

    Butler, Helen; Bowes, Glenn; Drew, Sarah; Glover, Sara; Godfrey, Celia; Patton, George; Trafford, Lea; Bond, Lyndal

    2010-03-01

    Schools and school systems are increasingly asked to use evidence-based strategies to promote the health and well-being of students. The dissemination of school-based health promotion research, however, offers particular challenges to conventional approaches to dissemination. Schools and education systems are multifaceted organizations that sit within constantly shifting broader contexts. This article argues that health promotion dissemination needs to be rethought for school communities as complex systems and that this requires understanding and harnessing the dynamic ecology of the sociopolitical context. In developing this argument, the authors draw on their experience of the dissemination process of a multilevel school-based intervention in a complex educational context. Building on this experience, they argue for the need to move beyond conventional dissemination strategies to a focus on active partnerships between developers and users of school-based intervention research and offer a conceptual tool for planning dissemination.

  10. Research on the Statistical Characteristics of Crosstalk in Naval Ships Wiring Harness Based on Polynomial Chaos Expansion Method

    Directory of Open Access Journals (Sweden)

    Chi Yaodan

    2017-08-01

    Full Text Available Crosstalk in wiring harness has been studied extensively for its importance in the naval ships electromagnetic compatibility field. An effective and high-efficiency method is proposed in this paper for analyzing Statistical Characteristics of crosstalk in wiring harness with random variation of position based on Polynomial Chaos Expansion (PCE. A typical 14-cable wiring harness was simulated as the object of research. Distance among interfering cable, affected cable and GND is synthesized and analyzed in both frequency domain and time domain. The model of naval ships wiring harness distribution parameter was established by utilizing Legendre orthogonal polynomials as basis functions along with prediction model of statistical characters. Detailed mean value, mean square error, probability density function and reasonable varying range of crosstalk in naval ships wiring harness are described in both time domain and frequency domain. Numerical experiment proves that the method proposed in this paper, not only has good consistency with the MC method can be applied in the naval ships EMC research field to provide theoretical support for guaranteeing safety, but also has better time-efficiency than the MC method. Therefore, the Polynomial Chaos Expansion method.

  11. AUTOMATIC RECOGNITION OF FALLS IN GAIT-SLIP: A HARNESS LOAD CELL BASED CRITERION

    OpenAIRE

    Yang, Feng; Pai, Yi-Chung

    2011-01-01

    Over-head-harness systems, equipped with load cell sensors, are essential to the participants’ safety and to the outcome assessment in perturbation training. The purpose of this study was to first develop an automatic outcome recognition criterion among young adults for gait-slip training and then verify such criterion among older adults. Each of 39 young and 71 older subjects, all protected by safety harness, experienced 8 unannounced, repeated slips, while walking on a 7-m walkway. Each tri...

  12. Environmental Control Unit Harness Project

    Science.gov (United States)

    Oliva-Buisson, Yvette J.

    2014-01-01

    Testing four new Environmental Control Unit Harnesses for improved user comfort during SCAPE operations. Phase I, testing in a lab environment, Phase II will continue testing the best candidates in a field environment.

  13. Harnessing Sun’s Energy with Quantum Dots Based Next Generation Solar Cell

    Science.gov (United States)

    Halim, Mohammad A.

    2012-01-01

    Our energy consumption relies heavily on the three components of fossil fuels (oil, natural gas and coal) and nearly 83% of our current energy is consumed from those sources. The use of fossil fuels, however, has been viewed as a major environmental threat because of their substantial contribution to greenhouse gases which are responsible for increasing the global average temperature. Last four decades, scientists have been searching for alternative sources of energy which need to be environmentally clean, efficient, cost-effective, renewable, and sustainable. One of the promising sustainable sources of energy can be achieved by harnessing sun energy through silicon wafer, organic polymer, inorganic dye, and quantum dots based solar cells. Among them, quantum dots have an exceptional property in that they can excite multiple electrons using only one photon. These dots can easily be synthesized, processed in solution, and incorporated into solar cell application. Interestingly, the quantum dots solar cells can exceed the Shockley-Queisser limit; however, it is a great challenge for other solar cell materials to exceed the limit. Theoretically, the quantum dots solar cell can boost the power conversion efficiency up to 66% and even higher to 80%. Moreover, in changing the size of the quantum dots one can utilize the Sun’s broad spectrum of visible and infrared ranges. This review briefly overviews the present performance of different materials-based solar cells including silicon wafer, dye-sensitized, and organic solar cells. In addition, recent advances of the quantum dots based solar cells which utilize cadmium sulfide/selenide, lead sulfide/selenide, and new carbon dots as light harvesting materials has been reviewed. A future outlook is sketched as to how one could improve the efficiency up to 10% from the current highest efficiency of 6.6%. PMID:28348320

  14. Harnessing Sun's Energy with Quantum Dots Based Next Generation Solar Cell.

    Science.gov (United States)

    Halim, Mohammad A

    2012-12-27

    Our energy consumption relies heavily on the three components of fossil fuels (oil, natural gas and coal) and nearly 83% of our current energy is consumed from those sources. The use of fossil fuels, however, has been viewed as a major environmental threat because of their substantial contribution to greenhouse gases which are responsible for increasing the global average temperature. Last four decades, scientists have been searching for alternative sources of energy which need to be environmentally clean, efficient, cost-effective, renewable, and sustainable. One of the promising sustainable sources of energy can be achieved by harnessing sun energy through silicon wafer, organic polymer, inorganic dye, and quantum dots based solar cells. Among them, quantum dots have an exceptional property in that they can excite multiple electrons using only one photon. These dots can easily be synthesized, processed in solution, and incorporated into solar cell application. Interestingly, the quantum dots solar cells can exceed the Shockley - Queisser limit; however, it is a great challenge for other solar cell materials to exceed the limit. Theoretically, the quantum dots solar cell can boost the power conversion efficiency up to 66% and even higher to 80%. Moreover, in changing the size of the quantum dots one can utilize the Sun's broad spectrum of visible and infrared ranges. This review briefly overviews the present performance of different materials-based solar cells including silicon wafer, dye-sensitized, and organic solar cells. In addition, recent advances of the quantum dots based solar cells which utilize cadmium sulfide/selenide, lead sulfide/selenide, and new carbon dots as light harvesting materials has been reviewed. A future outlook is sketched as to how one could improve the efficiency up to 10% from the current highest efficiency of 6.6%.

  15. Riding Horse Harness (Based on Materials from the Chulkovo Burial Ground

    Directory of Open Access Journals (Sweden)

    Grishakov Valeriy V.

    2013-12-01

    Full Text Available The items of riding horse harness (bits with psalia, stirrups, buckles, decorations of bridles are analyzed in the article on the basis of the materials from the Chulkovo (Murom burial ground site of the 8th-10th centuries, located on right bank of the Oka river. It has been established that the use of horse harness items by the Muroma culture population, which had left the Chulkovo burial ground, is in full correspondence with the general traditions of the Finno-Ugric peoples of the Volga river region characteristic of the 8th-10th centuries. The shapes of the bits correspond to both the steppe (bits with S-shaped and straight psalia and the local traditions (bits with two and three moving rings. A tendency to uniformity is observed in the tradition of stirrups production. The main differences of the Muroma burial grounds from the neighboring Mordovian ones consist in the presence of horse burials (not known among the Mordovians, and, on the other hand, in a practically complete lack of horse harness in the funeral set of human burials. It can be assumed that the importance of cavalry with the Muromа was lower than with the Mordovians who were living next to the steppe world.

  16. Har erhvervsuddannelserne en fremtid?

    DEFF Research Database (Denmark)

    Jørgensen, Christian Helms

    2012-01-01

    Har erhvervsuddannelserne en fremtid? Eller mere præcist: Har de en fremtid med den grundform som nu har fungeret i over 50 år? Det vil sige som et separat system baseret på vekseluddannelser, hvor hovedparten af uddannelserne foregår i praktik, og som i vid udstrækning styres af arbejdsmarkedets...

  17. Upgrading Wood-Based Industries: Harnessing the Social Network of Small-Scale Furniture Producers and Their Institutions

    Directory of Open Access Journals (Sweden)

    Melati ,

    2011-05-01

    Full Text Available Furniture is a major export commodity in Indonesia with a total value of USD 1.96 million in 2007.  Jepara District is one of the key location for wood furniture production with 15,271 furniture related business units employing 176,469 workers.  However, inefficiencies and power imbalances throughout the furniture value chain have resulted in overharvesting and uneven distribution of gains among the industry’s actors.  In contrast to price-setting international furniture retailers, small-scale producers enjoy the least value from their products.  In order to increase added value and competitiveness, small-scale furniture producers have made efforts to upgrade by harnessing their social network and institutions.  This paper describes small-scale furniture producers’ efforts to upgrade by utilising their social network and institutions in Jepara.  Data was collected through in-depth interviews with members of the small-scale furniture producers’ association.  The research provides insight into the nature of social networks and information flow and develops future scenarios to upgrade.  The scenarios will not only benefit the furniture industry in Jepara, but may also be adopted for similar industries throughout Indonesia and the world, and potentially improve many people’s economies and livelihoods.Keywords: wood-based industry, furniture, small-scale, social network, institution

  18. Harnessing the web information ecosystem with wiki-based visualization dashboards.

    Science.gov (United States)

    McKeon, Matt

    2009-01-01

    We describe the design and deployment of Dashiki, a public website where users may collaboratively build visualization dashboards through a combination of a wiki-like syntax and interactive editors. Our goals are to extend existing research on social data analysis into presentation and organization of data from multiple sources, explore new metaphors for these activities, and participate more fully in the web!s information ecology by providing tighter integration with real-time data. To support these goals, our design includes novel and low-barrier mechanisms for editing and layout of dashboard pages and visualizations, connection to data sources, and coordinating interaction between visualizations. In addition to describing these technologies, we provide a preliminary report on the public launch of a prototype based on this design, including a description of the activities of our users derived from observation and interviews.

  19. Harnessing cellular differentiation to improve ALA-based photodynamic therapy in an artificial skin model

    Science.gov (United States)

    Maytin, Edward; Anand, Sanjay; Sato, Nobuyuki; Mack, Judith; Ortel, Bernhard

    2005-04-01

    During ALA-based photodynamic therapy (PDT), a pro-drug (aminolevulinic acid; ALA) is taken up by tumor cells and metabolically converted to a photosensitizing intermediate (protoporphyrin IX; PpIX). ALA-based PDT, while an emerging treatment modality, remains suboptimal for most cancers (e.g. squamous cell carcinoma of the skin). Many treatment failures may be largely due to insufficient conversion of ALA to PpIX within cells. We discovered a novel way to increase the conversion of ALA to PpIX, by administering agents that can drive terminal differentiation (i.e., accelerate cellular maturation). Terminally-differentiated epithelial cells show higher levels of intracellular PpIX, apparently via increased levels of a rate-limiting enzyme, coproporphyrinogen oxidase (CPO). To study these mechanisms in a three-dimensional tissue, we developed an organotypic model that mimics true epidermal physiology in a majority of respects. A line of rat epidermal keratinocytes (REKs), when grown in raft cultures, displays all the features of a fully-differentiated epidermis. Addition of ALA to the culture medium results in ALA uptake and PpIX synthesis, with subsequent death of keratinocytes upon exposure to blue light. Using this model, we can manipulate cellular differentiation via three different approaches. (1) Vitamin D, a hormone that enhances keratinocyte differentiation; (2) Hoxb13, a nuclear transcription factor that affects the genetically-controlled differentiation program of stratifying cells (3) Hyaluronan, an abundant extracellular matrix molecule that regulates epidermal differentiation. Because the raft cultures contain only a single cell type (no blood, fibroblasts, etc.) the effects of terminal differentiation upon CPO, PpIX, and keratinocyte cell death can be specifically defined.

  20. Har Gobind Khorana

    Indian Academy of Sciences (India)

    IAS Admin

    Har Gobind Khorana, whose scientific career spanned a period of more than sixty ... Vancouver to the Institute for Enzyme Research at the University of Wisconsin in .... Khorana was very excited at the opportunity ... development of simplified ...

  1. Khorana, Prof. Har Gobind

    Indian Academy of Sciences (India)

    Elected: 1976 Honorary. Khorana, Prof. Har Gobind Nobel Laureate (Medicine) - 1968. Date of birth: 9 January 1922. Date of death: 9 November 2011. Last known address: Alfred P. Sloan Professor of, Biology and Chemistry, Massachusetts Institute of, Technology, 77 Massachusetts Ave., Cambridge, MA 02139, U.S.A..

  2. Har vi en virkelighedssans?

    DEFF Research Database (Denmark)

    Trettvik, Johan

    2013-01-01

    Vores teoretiske forhold til virkeligheden er meget omdiskuteret, og særlig spørgsmålet om, hvorvidt vores viden afspejler noget virkeligt, er centralt i diskussionen af begrebet om virkelighed. I psykologien har det sat sine spor ved enten en reduktionistisk holdning til sit genstandsfelt eller ...

  3. Har Gobind Khorana

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 17; Issue 12. Har Gobind Khorana - Early Years in Science and Transition from Chemistry to Chemical Biology. Uttam L Rajbhandary. General Article Volume 17 Issue 12 December 2012 pp 1125-1135 ...

  4. Kumar, Prof. Har Darshan

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1975 Section: Plant Sciences. Kumar, Prof. Har Darshan Ph.D. (London), FNA, FNASc. Date of birth: 25 February 1934. Specialization: Algology, Microbial Biotechnology, Genetics, Ecology and Environment Address: Mrigtrishna, B.32/32, H.K. 214, Saketnagar Colony, Naria, Varanasi 221 005, U.P.

  5. Divide and Conquer-Based 1D CNN Human Activity Recognition Using Test Data Sharpening.

    Science.gov (United States)

    Cho, Heeryon; Yoon, Sang Min

    2018-04-01

    Human Activity Recognition (HAR) aims to identify the actions performed by humans using signals collected from various sensors embedded in mobile devices. In recent years, deep learning techniques have further improved HAR performance on several benchmark datasets. In this paper, we propose one-dimensional Convolutional Neural Network (1D CNN) for HAR that employs a divide and conquer-based classifier learning coupled with test data sharpening. Our approach leverages a two-stage learning of multiple 1D CNN models; we first build a binary classifier for recognizing abstract activities, and then build two multi-class 1D CNN models for recognizing individual activities. We then introduce test data sharpening during prediction phase to further improve the activity recognition accuracy. While there have been numerous researches exploring the benefits of activity signal denoising for HAR, few researches have examined the effect of test data sharpening for HAR. We evaluate the effectiveness of our approach on two popular HAR benchmark datasets, and show that our approach outperforms both the two-stage 1D CNN-only method and other state of the art approaches.

  6. Divide and Conquer-Based 1D CNN Human Activity Recognition Using Test Data Sharpening

    Directory of Open Access Journals (Sweden)

    Heeryon Cho

    2018-04-01

    Full Text Available Human Activity Recognition (HAR aims to identify the actions performed by humans using signals collected from various sensors embedded in mobile devices. In recent years, deep learning techniques have further improved HAR performance on several benchmark datasets. In this paper, we propose one-dimensional Convolutional Neural Network (1D CNN for HAR that employs a divide and conquer-based classifier learning coupled with test data sharpening. Our approach leverages a two-stage learning of multiple 1D CNN models; we first build a binary classifier for recognizing abstract activities, and then build two multi-class 1D CNN models for recognizing individual activities. We then introduce test data sharpening during prediction phase to further improve the activity recognition accuracy. While there have been numerous researches exploring the benefits of activity signal denoising for HAR, few researches have examined the effect of test data sharpening for HAR. We evaluate the effectiveness of our approach on two popular HAR benchmark datasets, and show that our approach outperforms both the two-stage 1D CNN-only method and other state of the art approaches.

  7. Divide and Conquer-Based 1D CNN Human Activity Recognition Using Test Data Sharpening †

    Science.gov (United States)

    Yoon, Sang Min

    2018-01-01

    Human Activity Recognition (HAR) aims to identify the actions performed by humans using signals collected from various sensors embedded in mobile devices. In recent years, deep learning techniques have further improved HAR performance on several benchmark datasets. In this paper, we propose one-dimensional Convolutional Neural Network (1D CNN) for HAR that employs a divide and conquer-based classifier learning coupled with test data sharpening. Our approach leverages a two-stage learning of multiple 1D CNN models; we first build a binary classifier for recognizing abstract activities, and then build two multi-class 1D CNN models for recognizing individual activities. We then introduce test data sharpening during prediction phase to further improve the activity recognition accuracy. While there have been numerous researches exploring the benefits of activity signal denoising for HAR, few researches have examined the effect of test data sharpening for HAR. We evaluate the effectiveness of our approach on two popular HAR benchmark datasets, and show that our approach outperforms both the two-stage 1D CNN-only method and other state of the art approaches. PMID:29614767

  8. Dine marker har DNA

    DEFF Research Database (Denmark)

    Eckholdt, Annette; Winding, Anne; Krogh, Paul Henning

    2017-01-01

    Ordet "biodiversitet" og at det er noget, vi skal have mere af, nævnes hyppigt. Men hvad er biodiversitet, og hvordan måles det? Agrologisk har bedt et par eksperter fra Aarhus Universitet forklare, hvordan et DNA-aftryk af jord og vand kan erstatte optællinger i felten og sige noget om biodivers......Ordet "biodiversitet" og at det er noget, vi skal have mere af, nævnes hyppigt. Men hvad er biodiversitet, og hvordan måles det? Agrologisk har bedt et par eksperter fra Aarhus Universitet forklare, hvordan et DNA-aftryk af jord og vand kan erstatte optællinger i felten og sige noget om...

  9. Harnessing solar heat

    CERN Document Server

    Norton, Brian

    2013-01-01

    Systems engineered by man to harness solar heat in a controlled manner now include a diverse range of technologies each serving distinctive needs in particular climate contexts. This text covers the breadth of solar energy technologies for the conversion of solar energy to provide heat, either as the directly-used output or as an intermediary to other uses such as power generation or cooling. It is a wholly updated, extended and revised version of “Solar Energy Thermal Technology” first published in 1992. The text draws on the own author’s research and that of numerous colleagues and

  10. Design Process Improvement for Electric CAR Harness

    Science.gov (United States)

    Sawatdee, Thiwarat; Chutima, Parames

    2017-06-01

    In an automobile parts design company, the customer satisfaction is one of the most important factors for product design. Therefore, the company employs all means to focus its product design process based on the various requirements of customers resulting in high number of design changes. The objective of this research is to improve the design process of the electric car harness that effects the production scheduling by using Fault Tree Analysis (FTA) and Failure Mode and Effect Analysis (FMEA) as the main tools. FTA is employed for root cause analysis and FMEA is used to ranking a High Risk Priority Number (RPN) which is shows the priority of factors in the electric car harness that have high impact to the design of the electric car harness. After the implementation, the improvements are realized significantly since the number of design change is reduced from 0.26% to 0.08%.

  11. HARNESSING BIG DATA VOLUMES

    Directory of Open Access Journals (Sweden)

    Bogdan DINU

    2014-04-01

    Full Text Available Big Data can revolutionize humanity. Hidden within the huge amounts and variety of the data we are creating we may find information, facts, social insights and benchmarks that were once virtually impossible to find or were simply inexistent. Large volumes of data allow organizations to tap in real time the full potential of all the internal or external information they possess. Big data calls for quick decisions and innovative ways to assist customers and the society as a whole. Big data platforms and product portfolio will help customers harness to the full the value of big data volumes. This paper deals with technical and technological issues related to handling big data volumes in the Big Data environment.

  12. Computer-Based Testing: Test Site Security.

    Science.gov (United States)

    Rosen, Gerald A.

    Computer-based testing places great burdens on all involved parties to ensure test security. A task analysis of test site security might identify the areas of protecting the test, protecting the data, and protecting the environment as essential issues in test security. Protecting the test involves transmission of the examinations, identifying the…

  13. Building a bio-based industry in the Middle East through harnessing the potential of the Red Sea biodiversity

    DEFF Research Database (Denmark)

    Nielsen, Jens; Archer, John; Essack, Magbubah

    2017-01-01

    , represents a remarkable source of biodiversity that can be geared towards economical and sustainable bioproduction processes in the local area and can be competitive in the international bio-based economy. Recent bioprospecting studies, conducted by the King Abdullah University of Science and Technology...

  14. Building a bio-based industry in the Middle East through harnessing the potential of the Red Sea biodiversity

    KAUST Repository

    Nielsen, Jens; Archer, John A.C.; Essack, Magbubah; Bajic, Vladimir B.; Gojobori, Takashi; Mijakovic, Ivan

    2017-01-01

    The incentive for developing microbial cell factories for production of fuels and chemicals comes from the ability of microbes to deliver these valuable compounds at a reduced cost and with a smaller environmental impact compared to the analogous chemical synthesis. Another crucial advantage of microbes is their great biological diversity, which offers a much larger “catalog” of molecules than the one obtainable by chemical synthesis. Adaptation to different environments is one of the important drives behind microbial diversity. We argue that the Red Sea, which is a rather unique marine niche, represents a remarkable source of biodiversity that can be geared towards economical and sustainable bioproduction processes in the local area and can be competitive in the international bio-based economy. Recent bioprospecting studies, conducted by the King Abdullah University of Science and Technology, have established important leads on the Red Sea biological potential, with newly isolated strains of Bacilli and Cyanobacteria. We argue that these two groups of local organisms are currently most promising in terms of developing cell factories, due to their ability to operate in saline conditions, thus reducing the cost of desalination and sterilization. The ability of Cyanobacteria to perform photosynthesis can be fully exploited in this particular environment with one of the highest levels of irradiation on the planet. We highlight the importance of new experimental and in silico methodologies needed to overcome the hurdles of developing efficient cell factories from the Red Sea isolates.

  15. Building a bio-based industry in the Middle East through harnessing the potential of the Red Sea biodiversity.

    Science.gov (United States)

    Nielsen, Jens; Archer, John; Essack, Magbubah; Bajic, Vladimir B; Gojobori, Takashi; Mijakovic, Ivan

    2017-06-01

    The incentive for developing microbial cell factories for production of fuels and chemicals comes from the ability of microbes to deliver these valuable compounds at a reduced cost and with a smaller environmental impact compared to the analogous chemical synthesis. Another crucial advantage of microbes is their great biological diversity, which offers a much larger "catalog" of molecules than the one obtainable by chemical synthesis. Adaptation to different environments is one of the important drives behind microbial diversity. We argue that the Red Sea, which is a rather unique marine niche, represents a remarkable source of biodiversity that can be geared towards economical and sustainable bioproduction processes in the local area and can be competitive in the international bio-based economy. Recent bioprospecting studies, conducted by the King Abdullah University of Science and Technology, have established important leads on the Red Sea biological potential, with newly isolated strains of Bacilli and Cyanobacteria. We argue that these two groups of local organisms are currently most promising in terms of developing cell factories, due to their ability to operate in saline conditions, thus reducing the cost of desalination and sterilization. The ability of Cyanobacteria to perform photosynthesis can be fully exploited in this particular environment with one of the highest levels of irradiation on the planet. We highlight the importance of new experimental and in silico methodologies needed to overcome the hurdles of developing efficient cell factories from the Red Sea isolates.

  16. Building a bio-based industry in the Middle East through harnessing the potential of the Red Sea biodiversity

    KAUST Repository

    Nielsen, Jens

    2017-05-20

    The incentive for developing microbial cell factories for production of fuels and chemicals comes from the ability of microbes to deliver these valuable compounds at a reduced cost and with a smaller environmental impact compared to the analogous chemical synthesis. Another crucial advantage of microbes is their great biological diversity, which offers a much larger “catalog” of molecules than the one obtainable by chemical synthesis. Adaptation to different environments is one of the important drives behind microbial diversity. We argue that the Red Sea, which is a rather unique marine niche, represents a remarkable source of biodiversity that can be geared towards economical and sustainable bioproduction processes in the local area and can be competitive in the international bio-based economy. Recent bioprospecting studies, conducted by the King Abdullah University of Science and Technology, have established important leads on the Red Sea biological potential, with newly isolated strains of Bacilli and Cyanobacteria. We argue that these two groups of local organisms are currently most promising in terms of developing cell factories, due to their ability to operate in saline conditions, thus reducing the cost of desalination and sterilization. The ability of Cyanobacteria to perform photosynthesis can be fully exploited in this particular environment with one of the highest levels of irradiation on the planet. We highlight the importance of new experimental and in silico methodologies needed to overcome the hurdles of developing efficient cell factories from the Red Sea isolates.

  17. Targeting Rapamycin to Podocytes Using a Vascular Cell Adhesion Molecule-1 (VCAM-1-Harnessed SAINT-Based Lipid Carrier System.

    Directory of Open Access Journals (Sweden)

    Ganesh Ram R Visweswaran

    Full Text Available Together with mesangial cells, glomerular endothelial cells and the basement membrane, podocytes constitute the glomerular filtration barrier (GFB of the kidney. Podocytes play a pivotal role in the progression of various kidney-related diseases such as glomerular sclerosis and glomerulonephritis that finally lead to chronic end-stage renal disease. During podocytopathies, the slit-diaphragm connecting the adjacent podocytes are detached leading to severe loss of proteins in the urine. The pathophysiology of podocytopathies makes podocytes a potential and challenging target for nanomedicine development, though there is a lack of known molecular targets for cell selective drug delivery. To identify VCAM-1 as a cell-surface receptor that is suitable for binding and internalization of nanomedicine carrier systems by podocytes, we investigated its expression in the immortalized podocyte cell lines AB8/13 and MPC-5, and in primary podocytes. Gene and protein expression analyses revealed that VCAM-1 expression is increased by podocytes upon TNFα-activation for up to 24 h. This was paralleled by anti-VCAM-1 antibody binding to the TNFα-activated cells, which can be employed as a ligand to facilitate the uptake of nanocarriers under inflammatory conditions. Hence, we next explored the possibilities of using VCAM-1 as a cell-surface receptor to deliver the potent immunosuppressant rapamycin to TNFα-activated podocytes using the lipid-based nanocarrier system Saint-O-Somes. Anti-VCAM-1-rapamycin-SAINT-O-Somes more effectively inhibited the cell migration of AB8/13 cells than free rapamycin and non-targeted rapamycin-SAINT-O-Somes indicating the potential of VCAM-1 targeted drug delivery to podocytes.

  18. Sea floor topography and backscatter intensity of the Historic Area Remediation Site (HARS), offshore of New York, based on multibeam surveys conducted in 1996, 1998, and 2000

    Science.gov (United States)

    Butman, Bradford; Danforth, W.W.; Knowles, S.C.; May, Brian; Serrett, Laurie

    2000-01-01

    An area offshore of Sandy Hook, New Jersey, has been used extensively for disposal of dredged and other materials, derived from the New York/New Jersey Harbor and surrounding areas, since the late 1800's (Figure 1). Between 1976 and 1995, the New York Bight Dredged Material Disposal Site, also known as the Mud Dump Site (Figure 2), received on average about 6 million cubic yards of material each year from federal and private maintenance dredging and from harbor deepening activities (Massa and others, 1996). In September 1997 the Mud Dump Site (MDS) was closed as an official ocean disposal site by the U.S. Environmental Protection Agency (http://www.epa.gov/), and the MDS and surrounding areas were designated as the Historic Area Remediation Site (HARS). The HARS is subdivided into a Primary Remediation Area (PRA, subdivided into 9 cells), a Buffer Zone, and a No-Discharge Zone (Figure 2). The sea floor of the HARS, approximately 9 square nautical miles in area, is being remediated by placing at least a one-meter cap of Category I (clean) dredged material on top of the existing surface sediments that exhibit varying degrees of degradation. (See http://www.nan.usace.army.mil/business/prjlinks/dmmp/benefic/hars.htm)(Category I sediments have no potential short or long-term impacts and are acceptable for unrestricted ocean disposal (EPA, 1996)). About 1.1 million cubic yards of dredged material for remediation was placed in the HARS in 1999, and 2.5 million cubic yards in 2000. Three multibeam echosounder surveys were carried out to map the topography and surficial geology of the HARS. The surveys were conducted November 23 - December 3, 1996, October 26 - November 11, 1998, and April 6 - 30, 2000. The surveys were carried out as part of a larger survey of the Hudson Shelf Valley and adjacent shelf (Butman and others, 1998, (http://pubs.usgs.gov/openfile/of98-616/). This report presents maps showing topography, shaded relief, and backscatter intensity (a measure of sea

  19. Harnessing off-target effects

    DEFF Research Database (Denmark)

    Saginc, Gaye; Voellmy, Franziska; Linding, Rune

    2017-01-01

    The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action....

  20. Harness the Power of Technology

    Science.gov (United States)

    Duncan, Arne

    2011-01-01

    Today, U.S. educators are teaching in the midst of a technological revolution. Technology promises to provide innovative solutions in the nation's classrooms, just as it has transformed the way people communicate, socialize, and conduct business. In this article, the author argues that now is the time to harness technology to revolutionize the way…

  1. Which is the better forecasting model? A comparison between HAR-RV and multifractality volatility

    Science.gov (United States)

    Ma, Feng; Wei, Yu; Huang, Dengshi; Chen, Yixiang

    2014-07-01

    In this paper, by taking the 5-min high frequency data of the Shanghai Composite Index as example, we compare the forecasting performance of HAR-RV and Multifractal volatility, Realized volatility, Realized Bipower Variation and their corresponding short memory model with rolling windows forecasting method and the Model Confidence Set which is proved superior to SPA test. The empirical results show that, for six loss functions, HAR-RV outperforms other models. Moreover, to make the conclusions more precise and robust, we use the MCS test to compare the performance of their logarithms form models, and find that the HAR-log(RV) has a better performance in predicting future volatility. Furthermore, by comparing the two models of HAR-RV and HAR-log(RV), we conclude that, in terms of performance forecasting, the HAR-log(RV) model is the best model among models we have discussed in this paper.

  2. IRT-based test construction

    OpenAIRE

    van der Linden, Willem J.; Theunissen, T.J.J.M.; Boekkooi-Timminga, Ellen; Kelderman, Henk

    1987-01-01

    Four discussions of test construction based on item response theory (IRT) are presented. The first discussion, "Test Design as Model Building in Mathematical Programming" (T.J.J.M. Theunissen), presents test design as a decision process under certainty. A natural way of modeling this process leads to mathematical programming. General models of test construction are discussed, with information about algorithms and heuristics; ideas about the analysis and refinement of test constraints are also...

  3. Model-based security testing

    OpenAIRE

    Schieferdecker, Ina; Großmann, Jürgen; Schneider, Martin

    2012-01-01

    Security testing aims at validating software system requirements related to security properties like confidentiality, integrity, authentication, authorization, availability, and non-repudiation. Although security testing techniques are available for many years, there has been little approaches that allow for specification of test cases at a higher level of abstraction, for enabling guidance on test identification and specification as well as for automated test generation. Model-based security...

  4. Design, development, manufacture, testing, and delivery of devices for connection of solar cell panel circuitry to flat conductor cable solar cell array harness

    Science.gov (United States)

    Dillard, P. A.; Waddington, D.

    1971-01-01

    The technology status and problem areas which exist for the application of flat conductor cabling to solar cell arrays are summarized. Details covering the design, connector manufacture, and prototype test results are also summarized.

  5. Har lægers risikovillighed og symptomer på udbrændthed betydning for brugen af PSA-tests?

    DEFF Research Database (Denmark)

    Pedersen, Anette Fischer; Carlsen, Anders Helles; Vedsted, Peter

    2016-01-01

    Denne artikel er baseret på undersøgelsen "Association of GP's risk attitudes, level of empathy, and burnout status with PSA testing in primary care, som er publiceret i British Journal of General Practice, December 2015; 65(44): 845-851......Denne artikel er baseret på undersøgelsen "Association of GP's risk attitudes, level of empathy, and burnout status with PSA testing in primary care, som er publiceret i British Journal of General Practice, December 2015; 65(44): 845-851...

  6. Model-Based Security Testing

    Directory of Open Access Journals (Sweden)

    Ina Schieferdecker

    2012-02-01

    Full Text Available Security testing aims at validating software system requirements related to security properties like confidentiality, integrity, authentication, authorization, availability, and non-repudiation. Although security testing techniques are available for many years, there has been little approaches that allow for specification of test cases at a higher level of abstraction, for enabling guidance on test identification and specification as well as for automated test generation. Model-based security testing (MBST is a relatively new field and especially dedicated to the systematic and efficient specification and documentation of security test objectives, security test cases and test suites, as well as to their automated or semi-automated generation. In particular, the combination of security modelling and test generation approaches is still a challenge in research and of high interest for industrial applications. MBST includes e.g. security functional testing, model-based fuzzing, risk- and threat-oriented testing, and the usage of security test patterns. This paper provides a survey on MBST techniques and the related models as well as samples of new methods and tools that are under development in the European ITEA2-project DIAMONDS.

  7. Synthesis of Fluorescent Carbon Dots by Gastrointestinal Fluid Treatment of Mongolia Har Gabur

    Directory of Open Access Journals (Sweden)

    Tegexibaiyin Wang

    2017-01-01

    Full Text Available Har Gabur is the carbide obtained from pig manure by burning. The fluorescent carbon dots (CDs of Har Gabur were successfully synthesized through simulating the digestion process of human gastrointestinal tract. Transmission Electron Microscope (TEM analysis showed that the average size of the prepared Har Gabur CDs was 4 nm, with good solubility in water and strong fluorescence under UV irradiation. The X-ray and Raman results showed that the Har Gabur CDs were mainly composed of oxygen “O” and carbon “C” elements, in the forms of “C=O” and “C-O.” The bond energy results showed that the nitrogen “N” atom presented as “C-N” form, which indicated that Har Gabur CDs also contain “N.” In photobleaching assay, Har Gabur CDs showed excellent light stability compared with ordinary organic dye, fluorescein, and Rhodamine B. The fluorescence intensity of Har Gabur CDs was fairly stable within a wide pH range of 3–10. When L-lysine and L-cysteine were applied for the passivation stage, the relative quantum yields were improved by 1.53 and 3.68 times, respectively. Finally, the fluorescence properties of Har Gabur CDs were tested in cells and zebrafish, illustrating that Har Gabur CD has potential in the application of biological labeling and imaging.

  8. A New Harness For Use with Exercise Countermeasures-Validation of Improved Comfort and Loading with the Center for Space Medicine (CSM) Harness

    Data.gov (United States)

    National Aeronautics and Space Administration — The on-orbit treadmill harness Station Development Test Objective (SDTO) evaluation ran from Increment 21 through 25 aboard the International Space Station...

  9. Harnessing supramolecular peptide nanotechnology in biomedical applications.

    Science.gov (United States)

    Chan, Kiat Hwa; Lee, Wei Hao; Zhuo, Shuangmu; Ni, Ming

    2017-01-01

    The harnessing of peptides in biomedical applications is a recent hot topic. This arises mainly from the general biocompatibility of peptides, as well as from the ease of tunability of peptide structure to engineer desired properties. The ease of progression from laboratory testing to clinical trials is evident from the plethora of examples available. In this review, we compare and contrast how three distinct self-assembled peptide nanostructures possess different functions. We have 1) nanofibrils in biomaterials that can interact with cells, 2) nanoparticles that can traverse the bloodstream to deliver its payload and also be bioimaged, and 3) nanotubes that can serve as cross-membrane conduits and as a template for nanowire formation. Through this review, we aim to illustrate how various peptides, in their various self-assembled nanostructures, possess great promise in a wide range of biomedical applications and what more can be expected.

  10. Harness cavitation to improve processing

    Energy Technology Data Exchange (ETDEWEB)

    Pandit, A.G.; Moholkar, V.S. [Univ. of Bombay (India)

    1996-07-01

    Mention cavitation to most chemical engineers, and they undoubtedly think of it as an operational problem. Indeed, the rapid creation and then collapse of bubbles, which is after all what cavitation involves, can destroy pumps and erode other equipment. Cavitation, however, also can have a positive side--presuming it is designed for and not unplanned. In this article, the authors look at how cavitation can be harnessed to improve processes, and the mechanisms for inducing cavitation--ultrasonics and hydrodynamics--and their likely roles. Sonication, that is, the use of ultrasound, is the conventional approach for creating cavitation, and so they turn to it first. Over the past few years, a number of groups have attempted to solve the problem of scale-up and design of ultrasonic reactors. The authors review the systems that already exist and also explore a simpler and efficient alternative to the ultrasonic reactor, the hydrodynamic cavitation reactor.

  11. Kvote 2 optagelse og akademiske præstationer: Hvor stor betydning har det adgangsgivende eksamenssnit?

    Directory of Open Access Journals (Sweden)

    Lotte Dyhrberg ONeill

    2013-03-01

    Full Text Available Kvote 2 optagelse (optagelsesprøver til medicinstudiet har vist sig at have virket beskyttende på tidligt studiefrafald sammenlignet med kvote 1 optagelse på Syddansk Universitet. Dette prospektive kohorte studie af de samme kohorter viser, at de lavere adgangsgivende karakterer i kvote 2 gruppen samtidigt kun var forbundet med lidt lavere bachelor karaktergennemsnit. Admission testing appears to be protective against early dropout compared to grade-based admission for undergraduate medical students at the University of Southern Denmark. This prospective cohort study shows that the lower entry grades of the admission tested students were simultaneously associated with obtaining only slightly lower medical school grades.

  12. Harnessing dendritic cells in inflammatory skin diseases.

    Science.gov (United States)

    Chu, Chung-Ching; Di Meglio, Paola; Nestle, Frank O

    2011-02-01

    The skin immune system harbors a complex network of dendritic cells (DCs). Recent studies highlight a diverse functional specialization of skin DC subsets. In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms to ensure the maintenance of immune homeostasis, as well as in pathogenesis of chronic inflammation in the skin when excessive immune responses are initiated and unrestrained. Harnessing DCs by directly targeting DC-derived molecules or selectively modulate DC subsets is a convincing strategy to tackle inflammatory skin diseases. In this review we discuss recent advances underlining the functional specialization of skin DCs and discuss the potential implication for future DC-based therapeutic strategies. Copyright © 2011 Elsevier Ltd. All rights reserved.

  13. Risk Based Optimal Fatigue Testing

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Faber, M.H.; Kroon, I.B.

    1992-01-01

    Optimal fatigue life testing of materials is considered. Based on minimization of the total expected costs of a mechanical component a strategy is suggested to determine the optimal stress range levels for which additional experiments are to be performed together with an optimal value...

  14. Interface-based software testing

    Directory of Open Access Journals (Sweden)

    Aziz Ahmad Rais

    2016-10-01

    Full Text Available Software quality is determined by assessing the characteristics that specify how it should work, which are verified through testing. If it were possible to touch, see, or measure software, it would be easier to analyze and prove its quality. Unfortunately, software is an intangible asset, which makes testing complex. This is especially true when software quality is not a question of particular functions that can be tested through a graphical user interface. The primary objective of software architecture is to design quality of software through modeling and visualization. There are many methods and standards that define how to control and manage quality. However, many IT software development projects still fail due to the difficulties involved in measuring, controlling, and managing software quality. Software quality failure factors are numerous. Examples include beginning to test software too late in the development process, or failing properly to understand, or design, the software architecture and the software component structure. The goal of this article is to provide an interface-based software testing technique that better measures software quality, automates software quality testing, encourages early testing, and increases the software’s overall testability

  15. A Key Review of Non-Industrial Greywater Heat Harnessing

    Directory of Open Access Journals (Sweden)

    Abdur Rehman Mazhar

    2018-02-01

    Full Text Available The ever-growing concerns about making buildings more energy efficient and increasing the share of renewable energy used in them, has led to the development of ultra-low carbon buildings or passive houses. However, a huge potential still exists to lower the hot water energy demand, especially by harnessing heat from waste water exiting these buildings. Reusing this heat makes buildings more energy-efficient and this source is considered as a third-generation renewable energy technology, both factors conforming to energy policies throughout the world. Based on several theoretical and experimental studies, the potential to harness non-industrial waste water is quite high. As an estimate about 3.5 kWh of energy, per person per day could be harnessed and used directly, in many applications. A promising example of such an application, are low temperature fourth generation District Heating grids, with decentralized sources of heat. At the moment, heat exchangers and heat pumps are the only viable options to harness non-industrial waste heat. Both are used at different scales and levels of the waste-water treatment hierarchical pyramid. Apart from several unfavourable characteristics of these technologies, the associated exergetic efficiencies are low, in the range of 20–50%, even when cascaded combinations of both are used. To tackle these shortcomings, several promising trends and technologies are in the pipeline, to scavenge this small-scale source of heat to a large-scale benefit.

  16. Harnessing Intellectual Property for Development: Some Thoughts ...

    African Journals Online (AJOL)

    Harnessing Intellectual Property for Development: Some Thoughts on an Appropriate ... This will be achieved through the creation of an IP system that provides ... the good being protected and the manner in which the creative process unfolds.

  17. Harnessing supramolecular peptide nanotechnology in biomedical applications

    Directory of Open Access Journals (Sweden)

    Chan KH

    2017-02-01

    Full Text Available Kiat Hwa Chan,1 Wei Hao Lee,2 Shuangmu Zhuo,3 Ming Ni3 1Division of Science, Yale-NUS College, Singapore; 2Department of Chemistry, Krieger School of Arts & Sciences, Johns Hopkins University, Baltimore, MD, USA; 3Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, People’s Republic of China Abstract: The harnessing of peptides in biomedical applications is a recent hot topic. This arises mainly from the general biocompatibility of peptides, as well as from the ease of tunability of peptide structure to engineer desired properties. The ease of progression from laboratory testing to clinical trials is evident from the plethora of examples available. In this review, we compare and contrast how three distinct self-assembled peptide nanostructures possess different functions. We have 1 nanofibrils in biomaterials that can interact with cells, 2 nanoparticles that can traverse the bloodstream to deliver its payload and also be bioimaged, and 3 nanotubes that can serve as cross-membrane conduits and as a template for nanowire formation. Through this review, we aim to illustrate how various peptides, in their various self-assembled nanostructures, possess great promise in a wide range of biomedical applications and what more can be expected. Keywords: peptides, self-assembly, nanotechnology

  18. Me, Myself and My Team : How communications teams can harness the power of online impression management

    OpenAIRE

    Fieseler, Christian; Meckel, Miriam; Ranzini, Giulia

    2012-01-01

    The article is a short piece based on our EACD survey on the identity management practices of marketing and communication professeionals on how communications teams can harness the power of online impression management

  19. Interface-based software testing

    OpenAIRE

    Aziz Ahmad Rais

    2016-01-01

    Software quality is determined by assessing the characteristics that specify how it should work, which are verified through testing. If it were possible to touch, see, or measure software, it would be easier to analyze and prove its quality. Unfortunately, software is an intangible asset, which makes testing complex. This is especially true when software quality is not a question of particular functions that can be tested through a graphical user interface. The primary objective of softwar...

  20. Medicinalindustrien har brug for diagnoser som ADHD

    DEFF Research Database (Denmark)

    Fugl, Marie

    2008-01-01

    Det er ikke første gang, at medicinalindustriens evne til at finde nye markeder har medført nye eller bredere diagnoser. I det forrige årti så vi et parallelt forløb mellem et boom i antallet af depressionsdiagnoser og forbruget af lykkepiller. Interview med sociolog Thomas Brante. Udgivelsesdato...

  1. Appropriate administrative structures in harnessing water resources ...

    African Journals Online (AJOL)

    Appropriate administrative structures in harnessing water resources for sustainable growth in Nigeria. Lekan Oyebande. Abstract. No Abstract. Journal of Mining and Geology Vol. 42(1) 2006: 21-30. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT.

  2. Kyllinger har effektivt immunforsvar mod herpes

    DEFF Research Database (Denmark)

    Buchmann, Kurt

    2008-01-01

    Forskere ved Københavns Universitet, Fakultet for Biovidenskab har studeret kyllingens MHC molekyler og kan derigennem forklare hvorfor en særlig stamme indenfor denne art er modstandsdygtige mod en særlig herpesvirus. Udgivelsesdato: 18. januar 2008...

  3. Harnessing Collaborative Annotations on Online Formative Assessments

    Science.gov (United States)

    Lin, Jian-Wei; Lai, Yuan-Cheng

    2013-01-01

    This paper harnesses collaborative annotations by students as learning feedback on online formative assessments to improve the learning achievements of students. Through the developed Web platform, students can conduct formative assessments, collaboratively annotate, and review historical records in a convenient way, while teachers can generate…

  4. Harnessing Disorder in Compression Based Nanofabrication

    Science.gov (United States)

    Engel, Clifford John

    The future of nanotechnologies depends on the successful development of versatile, low-cost techniques for patterning micro- and nanoarchitectures. While most approaches to nanofabrication have focused primarily on making periodic structures at ever smaller length scales with an ultimate goal of massively scaling their production, I have focused on introducing control into relatively disordered nanofabrication systems. Well-ordered patterns are increasingly unnecessary for a growing range of applications, from anti-biofouling coatings to light trapping to omniphobic surfaces. The ability to manipulate disorder, at will and over multiple length scales, starting with the nanoscale, can open new prospects for textured substrates and unconventional applications. Taking advantage of previously considered defects; I have been able to develop nanofabrication techniques with potential for massive scalability and the incorporation into a wide range of potential application. This thesis first describes the manipulation of the non-Newtonian properties of liquid Ga and Ga alloys to confine the metal and metal alloys in gratings with sub-wavelength periodicities. Through a solid to liquid phase change, I was able to access the superior plasmonic properties of liquid Ga for the generation of surface plasmon polaritons (SPP). The switching contract between solid and liquid Ga confine in the nanogratings allowed for reversible manipulation of SPP properties through heating and cooling around the relatively low melting temperature of Ga (29.8 °C). The remaining chapters focus on the development and characterization of an all polymer wrinkle material system. Wrinkles, spontaneous disordered features that are produced in response to compressive force, are an ideal for a growing number of applications where fine feature control is no longer the main motivation. However the mechanical limitations of many wrinkle systems have restricted the potential applications of wrinkled surfaces. We developed a wrinkle material system that could be both tuned in feature size from as small as 30 nm up 10 ?m while maximizing the wrinkle amplitude at all wavelengths. By charactering the material properties of both the skin and substrate, we were able to generate wrinkle patterns with fine control over periodicity, amplitude, and orientation. The final chapters of this thesis focuses on the transfer of the wrinkle structure into functional materials aimed at manipulating biological adhesion of cells, optical absorption of solar cells, and sensor sensitivity of Raman substrates. The success of these applications was directly relative to the capabilities of our wrinkle system in controlling the surface chemistry, tuning the periodicity, and maximizing the amplitude for each application.

  5. Harnessing quantum transport by transient chaos.

    Science.gov (United States)

    Yang, Rui; Huang, Liang; Lai, Ying-Cheng; Grebogi, Celso; Pecora, Louis M

    2013-03-01

    Chaos has long been recognized to be generally advantageous from the perspective of control. In particular, the infinite number of unstable periodic orbits embedded in a chaotic set and the intrinsically sensitive dependence on initial conditions imply that a chaotic system can be controlled to a desirable state by using small perturbations. Investigation of chaos control, however, was largely limited to nonlinear dynamical systems in the classical realm. In this paper, we show that chaos may be used to modulate or harness quantum mechanical systems. To be concrete, we focus on quantum transport through nanostructures, a problem of considerable interest in nanoscience, where a key feature is conductance fluctuations. We articulate and demonstrate that chaos, more specifically transient chaos, can be effective in modulating the conductance-fluctuation patterns. Experimentally, this can be achieved by applying an external gate voltage in a device of suitable geometry to generate classically inaccessible potential barriers. Adjusting the gate voltage allows the characteristics of the dynamical invariant set responsible for transient chaos to be varied in a desirable manner which, in turn, can induce continuous changes in the statistical characteristics of the quantum conductance-fluctuation pattern. To understand the physical mechanism of our scheme, we develop a theory based on analyzing the spectrum of the generalized non-Hermitian Hamiltonian that includes the effect of leads, or electronic waveguides, as self-energy terms. As the escape rate of the underlying non-attracting chaotic set is increased, the imaginary part of the complex eigenenergy becomes increasingly large so that pointer states are more difficult to form, making smoother the conductance-fluctuation pattern.

  6. Semantics-based Automated Web Testing

    Directory of Open Access Journals (Sweden)

    Hai-Feng Guo

    2015-08-01

    Full Text Available We present TAO, a software testing tool performing automated test and oracle generation based on a semantic approach. TAO entangles grammar-based test generation with automated semantics evaluation using a denotational semantics framework. We show how TAO can be incorporated with the Selenium automation tool for automated web testing, and how TAO can be further extended to support automated delta debugging, where a failing web test script can be systematically reduced based on grammar-directed strategies. A real-life parking website is adopted throughout the paper to demonstrate the effectivity of our semantics-based web testing approach.

  7. Solar Radiation: Harnessing the Power

    Science.gov (United States)

    Rowland, Teri; Chambers, Lin; Holzer, Missy; Moore, Susan

    2009-01-01

    My NASA Data (Chambers et al. 2008) is a teaching tool available on NASA's website that offers microsets of real data in an easily accessible, user-friendly format. In this article, the authors describe a lesson plan based on an activity from My NASA Data, in which students explore parts of the United States where they would want to live if they…

  8. Harnessing Theories for Tool Support

    DEFF Research Database (Denmark)

    Liu, Zhiming; Mencl, Vladimir; Ravn, Anders Peter

    2006-01-01

    quality of such add-ins is to base them on sound formal foundations. In order to know where such add-ins will fit, we investigate the use of an existing successful commercial tool and identify suitable places for adding formally supported checking, transformation and generation modules. The paper...

  9. Harness the Energy of Collaboration

    Science.gov (United States)

    Lieberman, Ann; Miller, Lynne

    2016-01-01

    As they write about the Learning Communities standard in "Reach the Highest Standard in Professional Learning: Learning Communities," authors Ann Lieberman and Lynne Miller consider why communities have gained widespread attention and support and summarize the established research base about them. They also describe three contexts in…

  10. Arbejdsulykker! Alle har en historie

    DEFF Research Database (Denmark)

    Richter, Anne; Pedersen, Elsebet Frydendal

    in a trade school and in three carpentry companies in relation to five construction sites. The project draws on organizational culture theories of symbolic interactionism and on practice based learning i communities of practice. The methodological approach is primarily ethnographic. Four different cultures...

  11. Team-Based Testing Improves Individual Learning

    Science.gov (United States)

    Vogler, Jane S.; Robinson, Daniel H.

    2016-01-01

    In two experiments, 90 undergraduates took six tests as part of an educational psychology course. Using a crossover design, students took three tests individually without feedback and then took the same test again, following the process of team-based testing (TBT), in teams in which the members reached consensus for each question and answered…

  12. Model-based testing for software safety

    NARCIS (Netherlands)

    Gurbuz, Havva Gulay; Tekinerdogan, Bedir

    2017-01-01

    Testing safety-critical systems is crucial since a failure or malfunction may result in death or serious injuries to people, equipment, or environment. An important challenge in testing is the derivation of test cases that can identify the potential faults. Model-based testing adopts models of a

  13. Harnessing the Potential of Additive Manufacturing

    Science.gov (United States)

    2016-12-01

    31 Defense AT&L: November-December 2016 Harnessing the Potential of Additive Manufacturing Bill Decker Decker is director of Technology...achieve its goal of competition throughout the acquisition life cycle. When we look at additive manufacturing , we have a much different environment. To...Titanium-6 Aluminum-4 Vanadium with Powder Bed Fusion. This specification covers additively manufactured titanium-6 aluminum-4 vanadium (Ti-6Al-4V

  14. Harnessing supramolecular peptide nanotechnology in biomedical applications

    OpenAIRE

    Chan, Kiat Hwa; Lee, Wei Hao; Zhuo, Shuangmu; Ni, Ming

    2017-01-01

    Kiat Hwa Chan,1 Wei Hao Lee,2 Shuangmu Zhuo,3 Ming Ni3 1Division of Science, Yale-NUS College, Singapore; 2Department of Chemistry, Krieger School of Arts & Sciences, Johns Hopkins University, Baltimore, MD, USA; 3Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, People’s Republic of China Abstract: The harnessing of peptides in biomedic...

  15. Strain measurement based battery testing

    Science.gov (United States)

    Xu, Jeff Qiang; Steiber, Joe; Wall, Craig M.; Smith, Robert; Ng, Cheuk

    2017-05-23

    A method and system for strain-based estimation of the state of health of a battery, from an initial state to an aged state, is provided. A strain gauge is applied to the battery. A first strain measurement is performed on the battery, using the strain gauge, at a selected charge capacity of the battery and at the initial state of the battery. A second strain measurement is performed on the battery, using the strain gauge, at the selected charge capacity of the battery and at the aged state of the battery. The capacity degradation of the battery is estimated as the difference between the first and second strain measurements divided by the first strain measurement.

  16. Automation for a base station stability testing

    OpenAIRE

    Punnek, Elvis

    2016-01-01

    This Batchelor’s thesis was commissioned by Oy LM Ericsson Ab Oulu. The aim of it was to help to investigate and create a test automation solution for the stability testing of the LTE base station. The main objective was to create a test automation for a predefined test set. This test automation solution had to be created for specific environments and equipment. This work included creating the automation for the test cases and putting them to daily test automation jobs. The key factor...

  17. How can developing countries harness biotechnology to improve health?

    Directory of Open Access Journals (Sweden)

    Persad Deepa L

    2007-12-01

    Full Text Available Abstract Background The benefits of genomics and biotechnology are concentrated primarily in the industrialized world, while their potential to combat neglected diseases in the developing world has been largely untapped. Without building developing world biotechnology capacity to address local health needs, this disparity will only intensify. To assess the potential of genomics to address health needs in the developing world, the McLaughlin-Rotman Centre for Global Health, along with local partners, organized five courses on Genomics and Public Health Policy in the developing world. The overall objective of the courses was to collectively explore how to best harness genomics to improve health in each region. This article presents and analyzes the recommendations from all five courses. Discussion In this paper we analyze recommendations from 232 developing world experts from 58 countries who sought to answer how best to harness biotechnology to improve health in their regions. We divide their recommendations into four categories: science; finance; ethics, society and culture; and politics. Summary The Courses' recommendations can be summarized across the four categories listed above: Science - Collaborate through national, regional, and international networks - Survey and build capacity based on proven models through education, training, and needs assessments Finance - Develop regulatory and intellectual property frameworks for commercialization of biotechnology - Enhance funding and affordability of biotechnology - Improve the academic-industry interface and the role of small and medium enterprise Ethics, Society, Culture - Develop public engagement strategies to inform and educate the public about developments in genomics and biotechnology - Develop capacity to address ethical, social and cultural issues - Improve accessibility and equity Politics - Strengthen understanding, leadership and support at the political level for biotechnology

  18. Simulation-based Testing of Control Software

    Energy Technology Data Exchange (ETDEWEB)

    Ozmen, Ozgur [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Nutaro, James J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sanyal, Jibonananda [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Olama, Mohammed M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-02-10

    It is impossible to adequately test complex software by examining its operation in a physical prototype of the system monitored. Adequate test coverage can require millions of test cases, and the cost of equipment prototypes combined with the real-time constraints of testing with them makes it infeasible to sample more than a small number of these tests. Model based testing seeks to avoid this problem by allowing for large numbers of relatively inexpensive virtual prototypes that operate in simulation time at a speed limited only by the available computing resources. In this report, we describe how a computer system emulator can be used as part of a model based testing environment; specifically, we show that a complete software stack including operating system and application software - can be deployed within a simulated environment, and that these simulations can proceed as fast as possible. To illustrate this approach to model based testing, we describe how it is being used to test several building control systems that act to coordinate air conditioning loads for the purpose of reducing peak demand. These tests involve the use of ADEVS (A Discrete Event System Simulator) and QEMU (Quick Emulator) to host the operational software within the simulation, and a building model developed with the MODELICA programming language using Buildings Library and packaged as an FMU (Functional Mock-up Unit) that serves as the virtual test environment.

  19. Model-based testing for embedded systems

    CERN Document Server

    Zander, Justyna; Mosterman, Pieter J

    2011-01-01

    What the experts have to say about Model-Based Testing for Embedded Systems: "This book is exactly what is needed at the exact right time in this fast-growing area. From its beginnings over 10 years ago of deriving tests from UML statecharts, model-based testing has matured into a topic with both breadth and depth. Testing embedded systems is a natural application of MBT, and this book hits the nail exactly on the head. Numerous topics are presented clearly, thoroughly, and concisely in this cutting-edge book. The authors are world-class leading experts in this area and teach us well-used

  20. Kernel-based tests for joint independence

    DEFF Research Database (Denmark)

    Pfister, Niklas; Bühlmann, Peter; Schölkopf, Bernhard

    2018-01-01

    if the $d$ variables are jointly independent, as long as the kernel is characteristic. Based on an empirical estimate of dHSIC, we define three different non-parametric hypothesis tests: a permutation test, a bootstrap test and a test based on a Gamma approximation. We prove that the permutation test......We investigate the problem of testing whether $d$ random variables, which may or may not be continuous, are jointly (or mutually) independent. Our method builds on ideas of the two variable Hilbert-Schmidt independence criterion (HSIC) but allows for an arbitrary number of variables. We embed...... the $d$-dimensional joint distribution and the product of the marginals into a reproducing kernel Hilbert space and define the $d$-variable Hilbert-Schmidt independence criterion (dHSIC) as the squared distance between the embeddings. In the population case, the value of dHSIC is zero if and only...

  1. Validity evidence based on test content.

    Science.gov (United States)

    Sireci, Stephen; Faulkner-Bond, Molly

    2014-01-01

    Validity evidence based on test content is one of the five forms of validity evidence stipulated in the Standards for Educational and Psychological Testing developed by the American Educational Research Association, American Psychological Association, and National Council on Measurement in Education. In this paper, we describe the logic and theory underlying such evidence and describe traditional and modern methods for gathering and analyzing content validity data. A comprehensive review of the literature and of the aforementioned Standards is presented. For educational tests and other assessments targeting knowledge and skill possessed by examinees, validity evidence based on test content is necessary for building a validity argument to support the use of a test for a particular purpose. By following the methods described in this article, practitioners have a wide arsenal of tools available for determining how well the content of an assessment is congruent with and appropriate for the specific testing purposes.

  2. Methodology for testing and validating knowledge bases

    Science.gov (United States)

    Krishnamurthy, C.; Padalkar, S.; Sztipanovits, J.; Purves, B. R.

    1987-01-01

    A test and validation toolset developed for artificial intelligence programs is described. The basic premises of this method are: (1) knowledge bases have a strongly declarative character and represent mostly structural information about different domains, (2) the conditions for integrity, consistency, and correctness can be transformed into structural properties of knowledge bases, and (3) structural information and structural properties can be uniformly represented by graphs and checked by graph algorithms. The interactive test and validation environment have been implemented on a SUN workstation.

  3. Traceability in Model-Based Testing

    Directory of Open Access Journals (Sweden)

    Mathew George

    2012-11-01

    Full Text Available The growing complexities of software and the demand for shorter time to market are two important challenges that face today’s IT industry. These challenges demand the increase of both productivity and quality of software. Model-based testing is a promising technique for meeting these challenges. Traceability modeling is a key issue and challenge in model-based testing. Relationships between the different models will help to navigate from one model to another, and trace back to the respective requirements and the design model when the test fails. In this paper, we present an approach for bridging the gaps between the different models in model-based testing. We propose relation definition markup language (RDML for defining the relationships between models.

  4. Testlet-Based Multidimensional Adaptive Testing.

    Science.gov (United States)

    Frey, Andreas; Seitz, Nicki-Nils; Brandt, Steffen

    2016-01-01

    Multidimensional adaptive testing (MAT) is a highly efficient method for the simultaneous measurement of several latent traits. Currently, no psychometrically sound approach is available for the use of MAT in testlet-based tests. Testlets are sets of items sharing a common stimulus such as a graph or a text. They are frequently used in large operational testing programs like TOEFL, PISA, PIRLS, or NAEP. To make MAT accessible for such testing programs, we present a novel combination of MAT with a multidimensional generalization of the random effects testlet model (MAT-MTIRT). MAT-MTIRT compared to non-adaptive testing is examined for several combinations of testlet effect variances (0.0, 0.5, 1.0, and 1.5) and testlet sizes (3, 6, and 9 items) with a simulation study considering three ability dimensions with simple loading structure. MAT-MTIRT outperformed non-adaptive testing regarding the measurement precision of the ability estimates. Further, the measurement precision decreased when testlet effect variances and testlet sizes increased. The suggested combination of the MTIRT model therefore provides a solution to the substantial problems of testlet-based tests while keeping the length of the test within an acceptable range.

  5. Testlet-based Multidimensional Adaptive Testing

    Directory of Open Access Journals (Sweden)

    Andreas Frey

    2016-11-01

    Full Text Available Multidimensional adaptive testing (MAT is a highly efficient method for the simultaneous measurement of several latent traits. Currently, no psychometrically sound approach is available for the use of MAT in testlet-based tests. Testlets are sets of items sharing a common stimulus such as a graph or a text. They are frequently used in large operational testing programs like TOEFL, PISA, PIRLS, or NAEP. To make MAT accessible for such testing programs, we present a novel combination of MAT with a multidimensional generalization of the random effects testlet model (MAT-MTIRT. MAT-MTIRT compared to non-adaptive testing is examined for several combinations of testlet effect variances (0.0, 0.5, 1.0, 1.5 and testlet sizes (3 items, 6 items, 9 items with a simulation study considering three ability dimensions with simple loading structure. MAT-MTIRT outperformed non-adaptive testing regarding the measurement precision of the ability estimates. Further, the measurement precision decreased when testlet effect variances and testlet sizes increased. The suggested combination of the MTIRT model therefore provides a solution to the substantial problems of testlet-based tests while keeping the length of the test within an acceptable range.

  6. Harnessing Dendritic Cells for Tumor Antigen Presentation

    Energy Technology Data Exchange (ETDEWEB)

    Nierkens, Stefan [Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, Nijmegen 6525 GA (Netherlands); Janssen, Edith M., E-mail: edith.janssen@cchmc.org [Division of Molecular Immunology, Cincinnati Children' s Hospital Research Foundation, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 (United States)

    2011-04-26

    Dendritic cells (DC) are professional antigen presenting cells that are crucial for the induction of anti-tumor T cell responses. As a consequence, research has focused on the harnessing of DCs for therapeutic interventions. Although current strategies employing ex vivo-generated and tumor-antigen loaded DCs have been proven feasible, there are still many obstacles to overcome in order to improve clinical trial successes and offset the cost and complexity of customized cell therapy. This review focuses on one of these obstacles and a pivotal step for the priming of tumor-specific CD8{sup +} and CD4{sup +} T cells; the in vitro loading of DCs with tumor antigens.

  7. Diagnostic tests based on human basophils

    DEFF Research Database (Denmark)

    Kleine-Tebbe, Jörg; Erdmann, Stephan; Knol, Edward F

    2006-01-01

    -maximal responses, termed 'intrinsic sensitivity'. These variables give rise to shifts in the dose-response curves which, in a diagnostic setting where only a single antigen concentration is employed, may produce false-negative data. Thus, in order to meaningfully utilize the current basophil activation tests....... Diagnostic studies using CD63 or CD203c in hymenoptera, food and drug allergy are critically discussed. Basophil-based tests are indicated for allergy testing in selected cases but should only be performed by experienced laboratories....

  8. Harnessing Multiple Internal Reflections to Design Highly Absorptive Acoustic Metasurfaces

    Science.gov (United States)

    Shen, Chen; Cummer, Steven A.

    2018-05-01

    The rapid development of metasurfaces has enabled numerous intriguing applications with acoustically thin sheets. Here we report the theory and experimental realization of a nonresonant sound-absorbing strategy using metasurfaces by harnessing multiple internal reflections. We theoretically and numerically show that the higher-order diffraction of thin gradient-index metasurfaces is tied to multiple internal reflections inside the unit cells. Highly absorbing acoustic metasurfaces can be realized by enforcing multiple internal reflections together with a small amount of loss. A reflective gradient-index acoustic metasurface is designed based on the theory, and we further experimentally verify the performance using a three-dimensional printed prototype. Measurements show over 99% energy absorption at the peak frequency and a 95% energy absorption bandwidth of around 600 Hz. The proposed mechanism provides an alternative route for sound absorption without the necessity of high absorption of the individual unit cells.

  9. Safety Testing of Ammonium Nitrate Based Mixtures

    Science.gov (United States)

    Phillips, Jason; Lappo, Karmen; Phelan, James; Peterson, Nathan; Gilbert, Don

    2013-06-01

    Ammonium nitrate (AN)/ammonium nitrate based explosives have a lengthy documented history of use by adversaries in acts of terror. While historical research has been conducted on AN-based explosive mixtures, it has primarily focused on detonation performance while varying the oxygen balance between the oxidizer and fuel components. Similarly, historical safety data on these materials is often lacking in pertinent details such as specific fuel type, particle size parameters, oxidizer form, etc. A variety of AN-based fuel-oxidizer mixtures were tested for small-scale sensitivity in preparation for large-scale testing. Current efforts focus on maintaining a zero oxygen-balance (a stoichiometric ratio for active chemical participants) while varying factors such as charge geometry, oxidizer form, particle size, and inert diluent ratios. Small-scale safety testing was conducted on various mixtures and fuels. It was found that ESD sensitivity is significantly affected by particle size, while this is less so for impact and friction. Thermal testing is in progress to evaluate hazards that may be experienced during large-scale testing.

  10. Simple sorting algorithm test based on CUDA

    OpenAIRE

    Meng, Hongyu; Guo, Fangjin

    2015-01-01

    With the development of computing technology, CUDA has become a very important tool. In computer programming, sorting algorithm is widely used. There are many simple sorting algorithms such as enumeration sort, bubble sort and merge sort. In this paper, we test some simple sorting algorithm based on CUDA and draw some useful conclusions.

  11. Forum: Is Test-Based Accountability Dead?

    Science.gov (United States)

    Polikoff, Morgan S.; Greene, Jay P.; Huffman, Kevin

    2017-01-01

    Since the 2001 passage of the No Child Left Behind Act (NCLB), test-based accountability has been an organizing principle--perhaps "the" organizing principle--of efforts to improve American schools. But lately, accountability has been under fire from many critics, including Common Core opponents and those calling for more multifaceted…

  12. Fault tolerant system based on IDDQ testing

    Science.gov (United States)

    Guibane, Badi; Hamdi, Belgacem; Mtibaa, Abdellatif; Bensalem, Brahim

    2018-06-01

    Offline test is essential to ensure good manufacturing quality. However, for permanent or transient faults that occur during the use of the integrated circuit in an application, an online integrated test is needed as well. This procedure should ensure the detection and possibly the correction or the masking of these faults. This requirement of self-correction is sometimes necessary, especially in critical applications that require high security such as automotive, space or biomedical applications. We propose a fault-tolerant design for analogue and mixed-signal design complementary metal oxide (CMOS) circuits based on the quiescent current supply (IDDQ) testing. A defect can cause an increase in current consumption. IDDQ testing technique is based on the measurement of power supply current to distinguish between functional and failed circuits. The technique has been an effective testing method for detecting physical defects such as gate-oxide shorts, floating gates (open) and bridging defects in CMOS integrated circuits. An architecture called BICS (Built In Current Sensor) is used for monitoring the supply current (IDDQ) of the connected integrated circuit. If the measured current is not within the normal range, a defect is signalled and the system switches connection from the defective to a functional integrated circuit. The fault-tolerant technique is composed essentially by a double mirror built-in current sensor, allowing the detection of abnormal current consumption and blocks allowing the connection to redundant circuits, if a defect occurs. Spices simulations are performed to valid the proposed design.

  13. Using a micro computer based test bank

    International Nuclear Information System (INIS)

    Hamel, R.T.

    1987-01-01

    Utilizing a micro computer based test bank offers a training department many advantages and can have a positive impact upon training procedures and examination standards. Prior to data entry, Training Department management must pre-review the examination questions and answers to ensure compliance with examination standards and to verify the validity of all questions. Management must adhere to the TSD format since all questions require an enabling objective numbering scheme. Each question is entered under the enabling objective upon which it is based. Then the question is selected via the enabling objective. This eliminates any instructor bias because a random number generator chooses the test question. However, the instructor may load specific questions to create an emphasis theme for any test. The examination, answer and cover sheets are produced and printed within minutes. The test bank eliminates the large amount of time that is normally required for an instructor to formulate an examination. The need for clerical support is reduced by the elimination of typing examinations and also by the software's ability to maintain and generate student/course lists, attendance sheets, and grades. Software security measures limit access to the test bank, and the impromptu method used to generate and print an examination enhance its security

  14. Harnessing the power of emerging petascale platforms

    International Nuclear Information System (INIS)

    Mellor-Crummey, John

    2007-01-01

    As part of the US Department of Energy's Scientific Discovery through Advanced Computing (SciDAC-2) program, science teams are tackling problems that require computational simulation and modeling at the petascale. A grand challenge for computer science is to develop software technology that makes it easier to harness the power of these systems to aid scientific discovery. As part of its activities, the SciDAC-2 Center for Scalable Application Development Software (CScADS) is building open source software tools to support efficient scientific computing on the emerging leadership-class platforms. In this paper, we describe two tools for performance analysis and tuning that are being developed as part of CScADS: a tool for analyzing scalability and performance, and a tool for optimizing loop nests for better node performance. We motivate these tools by showing how they apply to S3D, a turbulent combustion code under development at Sandia National Laboratory. For S3D, our node performance analysis tool helped uncover several performance bottlenecks. Using our loop nest optimization tool, we transformed S3D's most costly loop nest to reduce execution time by a factor of 2.94 for a processor working on a 50 3 domain

  15. Harnessing the power of emerging petascale platforms

    Energy Technology Data Exchange (ETDEWEB)

    Mellor-Crummey, John [Associate Professor, Department of Computer Science, Rice University, Houston, TX (United States)

    2007-07-15

    As part of the US Department of Energy's Scientific Discovery through Advanced Computing (SciDAC-2) program, science teams are tackling problems that require computational simulation and modeling at the petascale. A grand challenge for computer science is to develop software technology that makes it easier to harness the power of these systems to aid scientific discovery. As part of its activities, the SciDAC-2 Center for Scalable Application Development Software (CScADS) is building open source software tools to support efficient scientific computing on the emerging leadership-class platforms. In this paper, we describe two tools for performance analysis and tuning that are being developed as part of CScADS: a tool for analyzing scalability and performance, and a tool for optimizing loop nests for better node performance. We motivate these tools by showing how they apply to S3D, a turbulent combustion code under development at Sandia National Laboratory. For S3D, our node performance analysis tool helped uncover several performance bottlenecks. Using our loop nest optimization tool, we transformed S3D's most costly loop nest to reduce execution time by a factor of 2.94 for a processor working on a 50{sup 3} domain.

  16. Enhancing SAT-Based Test Pattern Generation

    Institute of Scientific and Technical Information of China (English)

    LIU Xin; XIONG You-lun

    2005-01-01

    This paper presents modeling tools based on Boolean satisfiability (SAT) to solve problems of test generation for combinational circuits. It exploits an added layer to maintain circuit-related information and value justification relations to a generic SAT algorithm. It dovetails binary decision graphs (BDD) and SAT techniques to improve the efficiency of automatic test pattern generation (ATPG). More specifically, it first exploits inexpensive reconvergent fanout analysis of circuit to gather information on the local signal correlation by using BDD learning, then uses the above learned information to restrict and focus the overall search space of SAT-based ATPG. Its learning technique is effective and lightweight. The experimental results demonstrate the effectiveness of the approach.

  17. Black hole based tests of general relativity

    International Nuclear Information System (INIS)

    Yagi, Kent; Stein, Leo C

    2016-01-01

    General relativity has passed all solar system experiments and neutron star based tests, such as binary pulsar observations, with flying colors. A more exotic arena for testing general relativity is in systems that contain one or more black holes. Black holes are the most compact objects in the Universe, providing probes of the strongest-possible gravitational fields. We are motivated to study strong-field gravity since many theories give large deviations from general relativity only at large field strengths, while recovering the weak-field behavior. In this article, we review how one can probe general relativity and various alternative theories of gravity by using electromagnetic waves from a black hole with an accretion disk, and gravitational waves from black hole binaries. We first review model-independent ways of testing gravity with electromagnetic/gravitational waves from a black hole system. We then focus on selected examples of theories that extend general relativity in rather simple ways. Some important characteristics of general relativity include (but are not limited to) (i) only tensor gravitational degrees of freedom, (ii) the graviton is massless, (iii) no quadratic or higher curvatures in the action, and (iv) the theory is four-dimensional. Altering a characteristic leads to a different extension of general relativity: (i) scalar–tensor theories, (ii) massive gravity theories, (iii) quadratic gravity, and (iv) theories with large extra dimensions. Within each theory, we describe black hole solutions, their properties, and current and projected constraints on each theory using black hole based tests of gravity. We close this review by listing some of the open problems in model-independent tests and within each specific theory. (paper)

  18. Technical bases for the DWPF testing program

    International Nuclear Information System (INIS)

    Plodinec, M.J.

    1990-01-01

    The Defense Waste Processing Facility (DWPF) at the Savannah River Site (SRS) will be the first production facility in the United States for the immobilization of high-level nuclear waste. Production of DWPF canistered wasteforms will begin prior to repository licensing, so decisions on facility startup will have to be made before the final decisions on repository design are made. The Department of Energy's Office of Civilian Radioactive Waste Management (RW) has addressed this discrepancy by defining a Waste Acceptance Process. This process provides assurance that the borosilicate-glass wasteform, in a stainless-steel canister, produced by the DWPF will be acceptable for permanent storage in a federal repository. As part of this process, detailed technical specifications have been developed for the DWPF product. SRS has developed detailed strategies for demonstrating compliance with each of the Waste Acceptance Process specifications. An important part of the compliance is the testing which will be carried out in the DWPF. In this paper, the bases for each of the tests to be performed in the DWPF to establish compliance with the specifications are described, and the tests are detailed. The results of initial tests relating to characterization of sealed canisters are reported

  19. Flow Control in Wells Turbines for Harnessing Maximum Wave Power

    Science.gov (United States)

    Garrido, Aitor J.; Garrido, Izaskun; Otaola, Erlantz; Maseda, Javier

    2018-01-01

    Oceans, and particularly waves, offer a huge potential for energy harnessing all over the world. Nevertheless, the performance of current energy converters does not yet allow us to use the wave energy efficiently. However, new control techniques can improve the efficiency of energy converters. In this sense, the plant sensors play a key role within the control scheme, as necessary tools for parameter measuring and monitoring that are then used as control input variables to the feedback loop. Therefore, the aim of this work is to manage the rotational speed control loop in order to optimize the output power. With the help of outward looking sensors, a Maximum Power Point Tracking (MPPT) technique is employed to maximize the system efficiency. Then, the control decisions are based on the pressure drop measured by pressure sensors located along the turbine. A complete wave-to-wire model is developed so as to validate the performance of the proposed control method. For this purpose, a novel sensor-based flow controller is implemented based on the different measured signals. Thus, the performance of the proposed controller has been analyzed and compared with a case of uncontrolled plant. The simulations demonstrate that the flow control-based MPPT strategy is able to increase the output power, and they confirm both the viability and goodness. PMID:29439408

  20. Flow Control in Wells Turbines for Harnessing Maximum Wave Power.

    Science.gov (United States)

    Lekube, Jon; Garrido, Aitor J; Garrido, Izaskun; Otaola, Erlantz; Maseda, Javier

    2018-02-10

    Oceans, and particularly waves, offer a huge potential for energy harnessing all over the world. Nevertheless, the performance of current energy converters does not yet allow us to use the wave energy efficiently. However, new control techniques can improve the efficiency of energy converters. In this sense, the plant sensors play a key role within the control scheme, as necessary tools for parameter measuring and monitoring that are then used as control input variables to the feedback loop. Therefore, the aim of this work is to manage the rotational speed control loop in order to optimize the output power. With the help of outward looking sensors, a Maximum Power Point Tracking (MPPT) technique is employed to maximize the system efficiency. Then, the control decisions are based on the pressure drop measured by pressure sensors located along the turbine. A complete wave-to-wire model is developed so as to validate the performance of the proposed control method. For this purpose, a novel sensor-based flow controller is implemented based on the different measured signals. Thus, the performance of the proposed controller has been analyzed and compared with a case of uncontrolled plant. The simulations demonstrate that the flow control-based MPPT strategy is able to increase the output power, and they confirm both the viability and goodness.

  1. Tests results of skutterudite based thermoelectric unicouples

    International Nuclear Information System (INIS)

    Saber, Hamed H.; El-Genk, Mohamed S.; Caillat, Thierry

    2007-01-01

    Tests were performed of skutterudite based unicouples with (MAY-04) and without (MAR-03) metallic coating on the legs near the hot junction to quantify the effect on reducing performance degradation with operation time. The p-legs in the unicouples were made of CeFe 3.5 Co 0.5 Sb 12 and the n-legs of CoSb 3 . The MAY-04 test was performed in vacuum (∼9 x 10 -7 torr) for ∼2000 h at hot and cold junction temperatures of 892.1 ± 11.9 K and 316.1 ± 5.5 K, respectively, while the MAR-03 test was performed in argon cover gas (0.051-0.068 MPa) at 972.61 ± 10.0 K and 301.1 ± 5.1 K, respectively. The argon cover gas decreased antimony loss from the legs in the MAR-03 test, but marked degradation in performance occurred over time. Conversely, the metallic coating in the MAY-04 test was very effective in reducing performance degradation of the unicouple. Because the cross sectional areas of the legs in MAY-04 were larger than those in MAR-03, the measured electrical power of the former is much higher than that of the latter, but the Beginning of Test (BOT) open circuit voltages, V oc (204.2 mV) for both unicouples were almost the same. The peak electrical power of the MAY-04 unicouple decreased 12.35% from 1.62W e at BOT to 1.42W e after ∼2000 h of testing, while that of the MAR-03 unicouple decreased 25.37% from 0.67 to 0.5W e after 261 h of testing at the above temperatures. The estimated peak efficiency of the MAY-04 unicouple, shortly after BOT (10.65%), was only ∼0.37% points lower than the theoretical value, calculated assuming zero side heat losses and zero contact resistance per leg

  2. Har læreplanen (stadig) minimal betydning?

    DEFF Research Database (Denmark)

    Poulsen, Jens Aage

    2016-01-01

    Undervisningsministeriets læreplaner for skolens fag er centrale styredokumenter, der fastlægger formål og rammesætter indhold og form for undervisningen. Men hvilken betydning har de i praksis?...

  3. Harnessing two language games to enhance students' achievement ...

    African Journals Online (AJOL)

    Harnessing two language games to enhance students' achievement in English vocabulary: implications for ... This study investigated the use of games strategies on Senior Secondary One (SS1) students' ... AJOL African Journals Online.

  4. Divergence-based tests for model diagnostic

    Czech Academy of Sciences Publication Activity Database

    Hobza, Tomáš; Esteban, M. D.; Morales, D.; Marhuenda, Y.

    2008-01-01

    Roč. 78, č. 13 (2008), s. 1702-1710 ISSN 0167-7152 R&D Projects: GA MŠk 1M0572 Grant - others:Instituto Nacional de Estadistica (ES) MTM2006-05693 Institutional research plan: CEZ:AV0Z10750506 Keywords : goodness of fit * devergence statistics * GLM * model checking * bootstrap Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 0.445, year: 2008 http://library.utia.cas.cz/separaty/2008/SI/hobza-divergence-based%20tests%20for%20model%20diagnostic.pdf

  5. Antirandom Testing: A Distance-Based Approach

    Directory of Open Access Journals (Sweden)

    Shen Hui Wu

    2008-01-01

    Full Text Available Random testing requires each test to be selected randomly regardless of the tests previously applied. This paper introduces the concept of antirandom testing where each test applied is chosen such that its total distance from all previous tests is maximum. This spans the test vector space to the maximum extent possible for a given number of vectors. An algorithm for generating antirandom tests is presented. Compared with traditional pseudorandom testing, antirandom testing is found to be very effective when a high-fault coverage needs to be achieved with a limited number of test vectors. The superiority of the new approach is even more significant for testing bridging faults.

  6. Corneal topographer based on the Hartmann test.

    Science.gov (United States)

    Mejía, Yobani; Galeano, Janneth C

    2009-04-01

    The purpose of this article is to show the performance of a topographer based on the Hartmann test for convex surfaces of F/# approximately 1. This topographer, called "Hartmann Test topographer (HT topographer)," is a prototype developed in the Physics Department of the Universidad Nacional de Colombia. From the Hartmann pattern generated by the surface under test, and by the Fourier analysis and the optical aberration theory we obtain the sagitta (elevation map) of the surface. Then, taking the first and the second derivatives of the sagitta in the radial direction we obtain the meridional curvature map. The method is illustrated with an example. To check the performance of the HT topographer a toric surface, a revolution aspherical surface, and two human corneas were measured. Our results are compared with those obtained with a Placido ring topographer (Tomey TMS-4 videokeratoscope), and we show that our curvature maps are similar to those obtained with the Placido ring topographer. The HT topographer is able to reconstruct the corneal topography potentially eradicating the skew ray problem, therefore, corneal defects can be visualized more. The results are presented by elevation and meridional curvature maps.

  7. Harnessing the Flexibility of Thermostatic Loads in Microgrids with Solar Power Generation

    Directory of Open Access Journals (Sweden)

    Rosa Morales González

    2016-07-01

    Full Text Available This paper presents a demand response (DR framework that intertwines thermodynamic building models with a genetic algorithm (GA-based optimization method. The framework optimizes heating/cooling schedules of end-users inside a business park microgrid with local distributed generation from renewable energy sources (DG-RES based on two separate objectives: net load minimization and electricity cost minimization. DG-RES is treated as a curtailable resource in anticipation of future scenarios where the infeed of DG-RES to the regional distribution network could be limited. We test the DR framework with a case study of a refrigerated warehouse and an office building located in a business park with local PV generation. Results show the technical potential of the DR framework in harnessing the flexibility of the thermal masses from end-user sites in order to: (1 reduce the energy exchange at the point of connection; (2 reduce the cost of electricity for the microgrid end-users; and (3 increase the local utilization of DG-RES in cases where DG-RES exports to the grid are restricted. The results of this work can aid end-users and distribution network operators to reduce energy costs and energy consumption.

  8. Edge and core dynamics in harness

    International Nuclear Information System (INIS)

    Ball, R.

    2007-01-01

    Resistive kink oscillations in tokamak plasmas are usually treated as core localized events, yet there there are several mechanisms by which they may interact with the edge dynamics. This suggests that we may regulate edge oscillatory behaviour, or ELMs, by harnessing the natural or contrived sawtooth period and amplitude. In this work I investigate core-edge oscillatory entrainment through direct propagation of heat pulses, inductive coupling, and global higher order resonance effects. In the core of auxiliary heated tokamak plasmas the ineluctable rhythm of slow buildup and rapid conversion of potential energy governs electron and heat radial transport. The growth phase of the sawtooth is accompanied by significant reconnection, then during the collapse the temperature and density in the core fall dramatically. There is evidence from experiments in reversed field pinch devices that ensuing energy fluxes can affect flow shear and confinement at the edge. The basis for this study is the dynamical (BDS) model for edge plasma behavior that was derived from electrostatic resistive MHD equations. The BDS model reflects the major qualitative features of edge dynamics that have been observed, such as L-H transitions and associated ELMs, hysteresis, and spontaneous reversal of poloidal shear flow. Under poorly dissipative conditions the transient behavior of the model can exhibit period-doubling, blue-sky, homoclinic, and other exotic bifurcations. Thus we might ask questions such as: Is it possible to mode-lock the edge dynamics to the core sawteeth? Can we induce, or prevent, a change in direction of shear flow? What about MHD effects? Is core-edge communication one way or is there some feedback? In the simplest prototype for coupled core-edge dynamics I model the sawtooth crash as a periodic power input to the edge potential energy reservoir. This is effected by coupling the BDS model to the dynamical system u = u(1 - u 2 - x 2 ) - ω s x, x = x(1-u 2 -x 2 ) + ω s u

  9. Neuromarkers for Mental Disorders: Harnessing Population Neuroscience

    Directory of Open Access Journals (Sweden)

    Lee Jollans

    2018-06-01

    Full Text Available Despite abundant research into the neurobiology of mental disorders, to date neurobiological insights have had very little impact on psychiatric diagnosis or treatment. In this review, we contend that the search for neuroimaging biomarkers—neuromarkers—of mental disorders is a highly promising avenue toward improved psychiatric healthcare. However, many of the traditional tools used for psychiatric neuroimaging are inadequate for the identification of neuromarkers. Specifically, we highlight the need for larger samples and for multivariate analysis. Approaches such as machine learning are likely to be beneficial for interrogating high-dimensional neuroimaging data. We suggest that broad, population-based study designs will be important for developing neuromarkers of mental disorders, and will facilitate a move away from a phenomenological definition of mental disorder categories and toward psychiatric nosology based on biological evidence. We provide an outline of how the development of neuromarkers should occur, emphasizing the need for tests of external and construct validity, and for collaborative research efforts. Finally, we highlight some concerns regarding the development, and use of, neuromarkers in psychiatric healthcare.

  10. Model-Based Software Testing for Object-Oriented Software

    Science.gov (United States)

    Biju, Soly Mathew

    2008-01-01

    Model-based testing is one of the best solutions for testing object-oriented software. It has a better test coverage than other testing styles. Model-based testing takes into consideration behavioural aspects of a class, which are usually unchecked in other testing methods. An increase in the complexity of software has forced the software industry…

  11. NEIGHBORHOOD TEST DESIGN BASED ON HISTORIC PRECEDENTS

    Directory of Open Access Journals (Sweden)

    Besim S. Hakim

    2012-07-01

    Full Text Available There have been various attempts to emulate traditional architecture and to experiment with the form and aesthetics of building design. However, learning from precedents of urban morphology is rare. This design study is a test at the neighborhood level using the pattern of traditional courtyard housing that is prevalent in the majority of historic towns and cities of North Africa and the Middle East. The study is undertaken at five levels of design enquiry: dwelling types, dwelling groups, neighborhood segment and community center. All of which are synthesized into a full prototype neighborhood comprising of 428 dwelling units covering an area that includes circulation and the community center, of 17.6 hectares. The test demonstrates that the traditional pattern of neighborhoods that are based on the typology of the courtyard dwelling as the initial generator of urban form may be used to develop a contemporary settlement pattern that is compatible with current necessities of lifestyle, vehicular circulation,  including parking and infrastructure achieving an attractive livable environment with an overall gross density, that includes a community center, of about 24 dwelling units per hectare.

  12. Advances and limitations of visual conditioning protocols in harnessed bees.

    Science.gov (United States)

    Avarguès-Weber, Aurore; Mota, Theo

    2016-10-01

    Bees are excellent invertebrate models for studying visual learning and memory mechanisms, because of their sophisticated visual system and impressive cognitive capacities associated with a relatively simple brain. Visual learning in free-flying bees has been traditionally studied using an operant conditioning paradigm. This well-established protocol, however, can hardly be combined with invasive procedures for studying the neurobiological basis of visual learning. Different efforts have been made to develop protocols in which harnessed honey bees could associate visual cues with reinforcement, though learning performances remain poorer than those obtained with free-flying animals. Especially in the last decade, the intention of improving visual learning performances of harnessed bees led many authors to adopt distinct visual conditioning protocols, altering parameters like harnessing method, nature and duration of visual stimulation, number of trials, inter-trial intervals, among others. As a result, the literature provides data hardly comparable and sometimes contradictory. In the present review, we provide an extensive analysis of the literature available on visual conditioning of harnessed bees, with special emphasis on the comparison of diverse conditioning parameters adopted by different authors. Together with this comparative overview, we discuss how these diverse conditioning parameters could modulate visual learning performances of harnessed bees. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Accelerated load testing of geosynthetic base reinforced pavement test sections.

    Science.gov (United States)

    2011-02-01

    The main objective of this research is to evaluate the benefits of geosynthetic stabilization and reinforcement of subgrade/base aggregate layers in flexible pavements built on weak subgrades and the effect of pre-rut pavement sections, prior to the ...

  14. Validation of programmable industrial automation systems for safety critical applications in NPP's dynamic testing

    International Nuclear Information System (INIS)

    Haapanen, P.; Korhonen, J.

    1995-01-01

    The safety assessment of programmable automation systems can not totally be based on conventional probabilistic methods because of the difficulties in quantification of the reliability of the software as well as the hardware. Additional means shall therefore be used to gain more confidence on the system dependability. One central confidence building measure is the independent dynamic testing of the completed system. An automated test harness is needed to run the required large amount of test cases in a restricted time span. The prototype dynamic testing harness for programmable digital systems developed at the Technical Research Centre of Finland (VTT) is described in the presentation. (12 refs., 2 figs., 2 tabs.)

  15. Validation of programmable industrial automation systems for safety critical applications in NPP's; dynamic testing

    International Nuclear Information System (INIS)

    Haapanen, P.; Korhonen, J.

    1995-01-01

    The safety assessment of programmable automation systems cannot be totally be based on conventional probabilistic methods because of the difficulties in quantification of the reliability of the software as well as the hardware. Additional means shall therefore be used to gain more confidence on the system dependability. One central confidence building measure is the independent dynamic testing of the completed system. An automated test harness is needed to run the required large amount of test cases in a restricted time span. This paper describes a prototype dynamic testing harness for programmable digital systems developed at VTT. (author). 12 refs, 2 figs, 2 tabs

  16. Rule-based Test Generation with Mind Maps

    Directory of Open Access Journals (Sweden)

    Dimitry Polivaev

    2012-02-01

    Full Text Available This paper introduces basic concepts of rule based test generation with mind maps, and reports experiences learned from industrial application of this technique in the domain of smart card testing by Giesecke & Devrient GmbH over the last years. It describes the formalization of test selection criteria used by our test generator, our test generation architecture and test generation framework.

  17. Validity of selected cardiovascular field-based test among Malaysian ...

    African Journals Online (AJOL)

    Based on emerge obese problem among Malaysian, this research is formulated to validate published tests among healthy female adult. Selected test namely; 20 meter multi-stage shuttle run, 2.4km run test, 1 mile walk test and Harvard Step test were correlated with laboratory test (Bruce protocol) to find the criterion validity ...

  18. Neutron Sources for Standard-Based Testing

    Energy Technology Data Exchange (ETDEWEB)

    Radev, Radoslav [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); McLean, Thomas [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-11-10

    The DHS TC Standards and the consensus ANSI Standards use 252Cf as the neutron source for performance testing because its energy spectrum is similar to the 235U and 239Pu fission sources used in nuclear weapons. An emission rate of 20,000 ± 20% neutrons per second is used for testing of the radiological requirements both in the ANSI standards and the TCS. Determination of the accurate neutron emission rate of the test source is important for maintaining consistency and agreement between testing results obtained at different testing facilities. Several characteristics in the manufacture and the decay of the source need to be understood and accounted for in order to make an accurate measurement of the performance of the neutron detection instrument. Additionally, neutron response characteristics of the particular instrument need to be known and taken into account as well as neutron scattering in the testing environment.

  19. FMIT test-end instrumentation development bases

    International Nuclear Information System (INIS)

    Fuller, J.L.

    1982-06-01

    FMIT test-end measurements proposed for deuteron beam control, target diagnostics, and irradiation sample dosimetry are listed. The test-end refers to the area inside the test cell, but includes measurements inside and outside the cell. Justification, categorization, and limits qualification are presented for each measurement. Methods are purposefully de-emphasized in order to clarify the measurement needs, not techniques. Some discussion of techniques currently under investigation is given in the last section of the report

  20. GPS Device Testing Based on User Performance Metrics

    Science.gov (United States)

    2015-10-02

    1. Rationale for a Test Program Based on User Performance Metrics ; 2. Roberson and Associates Test Program ; 3. Status of, and Revisions to, the Roberson and Associates Test Program ; 4. Comparison of Roberson and DOT/Volpe Programs

  1. Efficient p-value evaluation for resampling-based tests

    KAUST Repository

    Yu, K.; Liang, F.; Ciampa, J.; Chatterjee, N.

    2011-01-01

    The resampling-based test, which often relies on permutation or bootstrap procedures, has been widely used for statistical hypothesis testing when the asymptotic distribution of the test statistic is unavailable or unreliable. It requires repeated

  2. Multi-objective Search-based Mobile Testing

    OpenAIRE

    Mao, K.

    2017-01-01

    Despite the tremendous popularity of mobile applications, mobile testing still relies heavily on manual testing. This thesis presents mobile test automation approaches based on multi-objective search. We introduce three approaches: Sapienz (for native Android app testing), Octopuz (for hybrid/web JavaScript app testing) and Polariz (for using crowdsourcing to support search-based mobile testing). These three approaches represent the primary scientific and technical contributions of the thesis...

  3. Computer-Aided Test Flow in Core-Based Design

    NARCIS (Netherlands)

    Zivkovic, V.; Tangelder, R.J.W.T.; Kerkhoff, Hans G.

    2000-01-01

    This paper copes with the efficient test-pattern generation in a core-based design. A consistent Computer-Aided Test (CAT) flow is proposed based on the required core-test strategy. It generates a test-pattern set for the embedded cores with high fault coverage and low DfT area overhead. The CAT

  4. Oscillation-based test in mixed-signal circuits

    CERN Document Server

    Sánchez, Gloria Huertas; Rueda, Adoración Rueda

    2007-01-01

    This book presents the development and experimental validation of the structural test strategy called Oscillation-Based Test - OBT in short. The results presented here assert, not only from a theoretical point of view, but also based on a wide experimental support, that OBT is an efficient defect-oriented test solution, complementing the existing functional test techniques for mixed-signal circuits.

  5. A rule-based software test data generator

    Science.gov (United States)

    Deason, William H.; Brown, David B.; Chang, Kai-Hsiung; Cross, James H., II

    1991-01-01

    Rule-based software test data generation is proposed as an alternative to either path/predicate analysis or random data generation. A prototype rule-based test data generator for Ada programs is constructed and compared to a random test data generator. Four Ada procedures are used in the comparison. Approximately 2000 rule-based test cases and 100,000 randomly generated test cases are automatically generated and executed. The success of the two methods is compared using standard coverage metrics. Simple statistical tests showing that even the primitive rule-based test data generation prototype is significantly better than random data generation are performed. This result demonstrates that rule-based test data generation is feasible and shows great promise in assisting test engineers, especially when the rule base is developed further.

  6. Reliability Estimation Based Upon Test Plan Results

    National Research Council Canada - National Science Library

    Read, Robert

    1997-01-01

    The report contains a brief summary of aspects of the Maximus reliability point and interval estimation technique as it has been applied to the reliability of a device whose surveillance tests contain...

  7. Harnessing the crowd to accelerate molecular medicine research.

    Science.gov (United States)

    Smith, Robert J; Merchant, Raina M

    2015-07-01

    Crowdsourcing presents a novel approach to solving complex problems within molecular medicine. By leveraging the expertise of fellow scientists across the globe, broadcasting to and engaging the public for idea generation, harnessing a scalable workforce for quick data management, and fundraising for research endeavors, crowdsourcing creates novel opportunities for accelerating scientific progress. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Har jeg forstået det rigtigt?

    DEFF Research Database (Denmark)

    Horsted, Mette Wenzel; Herly, Lene

    2009-01-01

    Interviews med sygeplejestuderende, der har problemer i forhold til biokemi, anatomi og fysiologi, gav indsigt i disse studerendes læringsstrategier i undervisningen. Ved bevidst at inddrage motiverende faktorer som inklusion, attitude, mening og kompetence (1), kan der skabes et læringsmiljø, hvor...

  9. Dansk Taxi Råd har brug for et sprogkursus

    DEFF Research Database (Denmark)

    Riis, Helle Bach

    2011-01-01

    16.10. afviser formanden for Dansk Taxi Råd, John Lindbom, at det nyindførte pointsystem har til hensigt at holde indvandrere fra at blive vognmænd. I stedet siger han, at det handler om at højne fagets status og serviceniveau. Dansk Taxi Råd kan komme langt ved at forbedre sin interkulturelle...

  10. Harness: Development of a multifunctional protective ship bulkhead

    NARCIS (Netherlands)

    Wal, R. van der; Meuers, R.J.C.

    2016-01-01

    HARNESS is a joint project between governments, industry and TNO with the objective to develop a multifunctional protective bulkhead for application on naval vessels. The multifunctional bulkhead aims at increasing the resilience of naval vessels, reduce damage and repair time and provide a safer

  11. Taso Mähar : avatud vannitoaga vanalinna korter / Gitte Hint

    Index Scriptorium Estoniae

    Hint, Gitte

    2003-01-01

    Modernne korter (220 m2). Sisearhitekt Taso Mähar, tema kommentaarid. Kogu korteri ulatuses on sisekujundusmaterjalidena kasutatud väärispuitu, metalli, marmorit ja klaasi. T. Mähari projekteeritud on trepp ja piirded, kamin, baarilett ja õhukesed alumiiniumraamidel mattklaasidega uksed. Ill.: I ja II korruse plaan, 8 värv. vaadet

  12. Likelihood based testing for no fractional cointegration

    DEFF Research Database (Denmark)

    Lasak, Katarzyna

    . The standard cointegration analysis only considers the assumption that deviations from equilibrium can be integrated of order zero, which is very restrictive in many cases and may imply an important loss of power in the fractional case. We consider the alternative hypotheses with equilibrium deviations...... that can be mean reverting with order of integration possibly greater than zero. Moreover, the degree of fractional cointegration is not assumed to be known, and the asymptotic null distribution of both tests is found when considering an interval of possible values. The power of the proposed tests under...

  13. TREAT (TREe-based Association Test)

    Science.gov (United States)

    TREAT is an R package for detecting complex joint effects in case-control studies. The test statistic is derived from a tree-structure model by recursive partitioning the data. Ultra-fast algorithm is designed to evaluate the significance of association between candidate gene and disease outcome

  14. Gamifying quantum research: harnessing human intuition

    Science.gov (United States)

    Sherson, Jacob

    In the emerging field of citizen science ordinary citizens have already contributed to research in as diverse fields as astronomy, protein and RNA folding, and neuron mapping by playing online games. In the www.scienceathome.org project, we have extended this democratized research to the realm of quantum physics by gamifying a class of challenges related to optimization of gate operations in a quantum computer. The games have been played by more than 150,000 players and perhaps surprisingly we observe that a large fraction of the players outperform state-of-the-art optimization algorithms. With a palette of additional games within cognitive science, behavioral economics, and corporate innovation we investigate the general features of individual and collaborative problem solving to shed additional light on the process of human intuition and innovation and potentially develop novel models of artificial intelligence. We have also developed and tested in classrooms educational games within classical and quantum physics and mathematics at high-school and university level. The games provide individualized learning and enhance motivation for the core curriculum by actively creating links to modern research challenges, see eg. Finally, we have recently launched our new democratic lab: an easily accessible remote interface for our ultra-cold atoms experiment allowing amateur scientists, students, and research institutions world-wide to perform state-of-the-art quantum experimentation. In first tests, nearly a thousand players helped optimize the production of our BEC and discovered novel efficient strategies.

  15. Automated Search-Based Robustness Testing for Autonomous Vehicle Software

    Directory of Open Access Journals (Sweden)

    Kevin M. Betts

    2016-01-01

    Full Text Available Autonomous systems must successfully operate in complex time-varying spatial environments even when dealing with system faults that may occur during a mission. Consequently, evaluating the robustness, or ability to operate correctly under unexpected conditions, of autonomous vehicle control software is an increasingly important issue in software testing. New methods to automatically generate test cases for robustness testing of autonomous vehicle control software in closed-loop simulation are needed. Search-based testing techniques were used to automatically generate test cases, consisting of initial conditions and fault sequences, intended to challenge the control software more than test cases generated using current methods. Two different search-based testing methods, genetic algorithms and surrogate-based optimization, were used to generate test cases for a simulated unmanned aerial vehicle attempting to fly through an entryway. The effectiveness of the search-based methods in generating challenging test cases was compared to both a truth reference (full combinatorial testing and the method most commonly used today (Monte Carlo testing. The search-based testing techniques demonstrated better performance than Monte Carlo testing for both of the test case generation performance metrics: (1 finding the single most challenging test case and (2 finding the set of fifty test cases with the highest mean degree of challenge.

  16. Trialing a Tablet PC Based Language Test

    Science.gov (United States)

    Litzler, Mary Frances; Garcia Laborda, Jesus

    2015-01-01

    Designing tests is a sophisticated task due to issues such as rubrics, validation and impact. Delivery has become another key issue in recent years. Recent research projects in Spain (García Laborda et al.s, 2010, García Laborda, 2012; García Laborda et al., 2014; Bueno Alastuey et al., 2014) have been working mainly with technological devices as…

  17. Computer-Aided Test Flow in Core-Based Design

    NARCIS (Netherlands)

    Zivkovic, V.; Tangelder, R.J.W.T.; Kerkhoff, Hans G.

    2000-01-01

    This paper copes with the test-pattern generation and fault coverage determination in the core based design. The basic core-test strategy that one has to apply in the core-based design is stated in this work. A Computer-Aided Test (CAT) flow is proposed resulting in accurate fault coverage of

  18. Association test based on SNP set: logistic kernel machine based test vs. principal component analysis.

    Directory of Open Access Journals (Sweden)

    Yang Zhao

    Full Text Available GWAS has facilitated greatly the discovery of risk SNPs associated with complex diseases. Traditional methods analyze SNP individually and are limited by low power and reproducibility since correction for multiple comparisons is necessary. Several methods have been proposed based on grouping SNPs into SNP sets using biological knowledge and/or genomic features. In this article, we compare the linear kernel machine based test (LKM and principal components analysis based approach (PCA using simulated datasets under the scenarios of 0 to 3 causal SNPs, as well as simple and complex linkage disequilibrium (LD structures of the simulated regions. Our simulation study demonstrates that both LKM and PCA can control the type I error at the significance level of 0.05. If the causal SNP is in strong LD with the genotyped SNPs, both the PCA with a small number of principal components (PCs and the LKM with kernel of linear or identical-by-state function are valid tests. However, if the LD structure is complex, such as several LD blocks in the SNP set, or when the causal SNP is not in the LD block in which most of the genotyped SNPs reside, more PCs should be included to capture the information of the causal SNP. Simulation studies also demonstrate the ability of LKM and PCA to combine information from multiple causal SNPs and to provide increased power over individual SNP analysis. We also apply LKM and PCA to analyze two SNP sets extracted from an actual GWAS dataset on non-small cell lung cancer.

  19. Harnessing Context for Vandalism Detection in Wikipedia

    Directory of Open Access Journals (Sweden)

    Lakshmish Ramaswamy

    2014-05-01

    Full Text Available The importance of collaborative social media (CSM applications such as Wikipedia to modern free societies can hardly be overemphasized. By allowing end users to freely create and edit content, Wikipedia has greatly facilitated democratization of information. However, over the past several years, Wikipedia has also become susceptible to vandalism, which has adversely affected its information quality. Traditional vandalism detection techniques that rely upon simple textual features such as spammy or abusive words have not been very effective in combating sophisticated vandal attacks that do not contain common vandalism markers. In this paper, we propose a context-based vandalism detection framework for Wikipedia. We first propose a contextenhanced finite state model for representing the context evolution ofWikipedia articles. This paper identifies two distinct types of context that are potentially valuable for vandalism detection, namely content-context and contributor-context. The distinguishing powers of these contexts are discussed by providing empirical results. We design two novel metrics for measuring how well the content-context of an incoming edit fits into the topic and the existing content of a Wikipedia article. We outline machine learning-based vandalism identification schemes that utilize these metrics. Our experiments indicate that utilizing context can substantially improve vandalism detection accuracy.

  20. Test Review: Test of English as a Foreign Language[TM]--Internet-Based Test (TOEFL iBT[R])

    Science.gov (United States)

    Alderson, J. Charles

    2009-01-01

    In this article, the author reviews the TOEFL iBT which is the latest version of the TOEFL, whose history stretches back to 1961. The TOEFL iBT was introduced in the USA, Canada, France, Germany and Italy in late 2005. Currently the TOEFL test is offered in two testing formats: (1) Internet-based testing (iBT); and (2) paper-based testing (PBT).…

  1. Testing for Statistical Discrimination based on Gender

    OpenAIRE

    Lesner, Rune Vammen

    2016-01-01

    This paper develops a model which incorporates the two most commonly cited strands of the literature on statistical discrimination, namely screening discrimination and stereotyping. The model is used to provide empirical evidence of statistical discrimination based on gender in the labour market. It is shown that the implications of both screening discrimination and stereotyping are consistent with observable wage dynamics. In addition, it is found that the gender wage gap decreases in tenure...

  2. [Generalized neonatal screening based on laboratory tests].

    Science.gov (United States)

    Ardaillou, Raymond; Le Gall, Jean-Yves

    2006-11-01

    Implementation of a generalized screening program for neonatal diseases must obey precise rules. The disease must be severe, recognizable at an early stage, amenable to an effective treatment, detectable with a non expensive and widely applicable test; it must also be a significant public health problem. Subjects with positive results must be offered immediate treatment or prevention. All screening programs must be regularly evaluated. In France, since 1978, a national screening program has been organized by a private association ("Association française pour le dépistage et la prévention des handicaps de l'enfant") and supervised by the "Caisse nationale d'assurance maladie" and "Direction Générale de la Sante". Five diseases are now included in the screening program: phenylketonuria, hypothyroidism, congenital adrenal hyperplasia, cystic fibrosis and sickle cell disease (the latter only in at-risk newborns). Toxoplasmosis is a particular problem because only the children of mothers who were not tested during the pregnancy or who seroconverted are screened. Neonatal screening for phenylketonuria and hypothyrodism is unanimously recommended. Screening for congenital adrenal hyperplasia is approved in most countries. Cases of sickle cell disease and cystic fibrosis are more complex because--not all children who carry the mutations develop severe forms;--there is no curative treatment;--parents may become anxious, even though the phenotype is sometimes mild or even asymptomatic. Supporters of screening stress the benefits of early diagnosis (which extends the life expectancy of these children, particularly in the case of sickle cell disease), the fact that it opens up the possibility of prenatal screening of future pregnancies, and the utility of informing heterozygous carriers identified by familial screening. Neonatal screening for other diseases is under discussion. Indeed, technical advances such as tandem mass spectrometry make it possible to detect about 50

  3. Harnessing the power of the grassroots to conduct public health research in sub-Saharan Africa: a case study from western Kenya in the adaptation of community-based participatory research (CBPR) approaches

    Science.gov (United States)

    2013-01-01

    Background Community-based participatory research (CBPR) is a collaborative approach to research that involves the equitable participation of those affected by an issue. As the field of global public health grows, the potential of CBPR to build capacity and to engage communities in identification of problems and development and implementation of solutions in sub-Saharan Africa has yet to be fully tapped. The Orphaned and Separated Children’s Assessments Related to their Health and Well-Being (OSCAR) project is a longitudinal cohort of orphaned and non-orphaned children in Kenya. This paper will describe how CBPR approaches and principles can be incorporated and adapted into the study design and methods of a longitudinal epidemiological study in sub-Saharan Africa using this project as an example. Methods The CBPR framework we used involves problem identification, feasibility and planning; implementation; and evaluation and dissemination. This case study will describe how we have engaged the community and adapted CBPR methods to OSCAR’s Health and Well-being Project’s corresponding to this framework in four phases: 1) community engagement, 2) sampling and recruitment, 3) retention, validation, and follow-up, and 4) analysis, interpretation and dissemination. Results To date the study has enrolled 3130 orphaned and separated children, including children living in institutional environments, those living in extended family or other households in the community, and street-involved children and youth. Community engagement and participation was integral in refining the study design and identifying research questions that were impacting the community. Through the participation of village Chiefs and elders we were able to successfully identify eligible households and randomize the selection of participants. The on-going contribution of the community in the research process has been vital to participant retention and data validation while ensuring cultural and

  4. Harnessing natural diversity to probe metabolic pathways.

    Directory of Open Access Journals (Sweden)

    Oliver R Homann

    2005-12-01

    Full Text Available Analyses of cellular processes in the yeast Saccharomyces cerevisiae rely primarily upon a small number of highly domesticated laboratory strains, leaving the extensive natural genetic diversity of the model organism largely unexplored and unexploited. We asked if this diversity could be used to enrich our understanding of basic biological processes. As a test case, we examined a simple trait: the utilization of di/tripeptides as nitrogen sources. The capacity to import small peptides is likely to be under opposing selective pressures (nutrient utilization versus toxin vulnerability and may therefore be sculpted by diverse pathways and strategies. Hitherto, dipeptide utilization in S. cerevisiae was solely ascribed to the activity of a single protein, the Ptr2p transporter. Using high-throughput phenotyping and several genetically diverse strains, we identified previously unknown cellular activities that contribute to this trait. We find that the Dal5p allantoate/ureidosuccinate permease is also capable of facilitating di/tripeptide transport. Moreover, even in the absence of Dal5p and Ptr2p, an additional activity--almost certainly the periplasmic asparaginase II Asp3p--facilitates the utilization of dipeptides with C-terminal asparagine residues by a different strategy. Another, as-yet-unidentified activity enables the utilization of dipeptides with C-terminal arginine residues. The relative contributions of these activities to the utilization of di/tripeptides vary among the strains analyzed, as does the vulnerability of these strains to a toxic dipeptide. Only by sampling the genetic diversity of multiple strains were we able to uncover several previously unrecognized layers of complexity in this metabolic pathway. High-throughput phenotyping facilitates the rapid exploration of the molecular basis of biological complexity, allowing for future detailed investigation of the selective pressures that drive microbial evolution.

  5. Performance-based containment leakage testing

    International Nuclear Information System (INIS)

    Cybulskis, P.

    1995-01-01

    The U.S. Nuclear Regulatory Commission (NRC) is reviewing regulatory requirements in an effort to revise those that are marginal to safety but impose significant burdens on licensees. Identification of requirements marginal to safety and development and evaluation of alternatives utilize the NRC safety goals and insights from probabilistic risk assessments (PRAs). Since earlier studies found design-basis containment leakage to be a minor contributor to reactor accident risk, containment leakage testing has been selected as a candidate for change in regulations. This paper summarizes the technical analyses supporting the NRC proposal to amend Appendix J of 10 CFR Part 50 as its first effort to decrease unnecessary regulatory burdens on licensees

  6. Protein-Based Urine Test Predicts Kidney Transplant Outcomes

    Science.gov (United States)

    ... News Releases News Release Thursday, August 22, 2013 Protein-based urine test predicts kidney transplant outcomes NIH- ... supporting development of noninvasive tests. Levels of a protein in the urine of kidney transplant recipients can ...

  7. Harnessing biomechanics to develop cartilage regeneration strategies.

    Science.gov (United States)

    Athanasiou, Kyriacos A; Responte, Donald J; Brown, Wendy E; Hu, Jerry C

    2015-02-01

    As this review was prepared specifically for the American Society of Mechanical Engineers H.R. Lissner Medal, it primarily discusses work toward cartilage regeneration performed in Dr. Kyriacos A. Athanasiou's laboratory over the past 25 years. The prevalence and severity of degeneration of articular cartilage, a tissue whose main function is largely biomechanical, have motivated the development of cartilage tissue engineering approaches informed by biomechanics. This article provides a review of important steps toward regeneration of articular cartilage with suitable biomechanical properties. As a first step, biomechanical and biochemical characterization studies at the tissue level were used to provide design criteria for engineering neotissues. Extending this work to the single cell and subcellular levels has helped to develop biochemical and mechanical stimuli for tissue engineering studies. This strong mechanobiological foundation guided studies on regenerating hyaline articular cartilage, the knee meniscus, and temporomandibular joint (TMJ) fibrocartilage. Initial tissue engineering efforts centered on developing biodegradable scaffolds for cartilage regeneration. After many years of studying scaffold-based cartilage engineering, scaffoldless approaches were developed to address deficiencies of scaffold-based systems, resulting in the self-assembling process. This process was further improved by employing exogenous stimuli, such as hydrostatic pressure, growth factors, and matrix-modifying and catabolic agents, both singly and in synergistic combination to enhance neocartilage functional properties. Due to the high cell needs for tissue engineering and the limited supply of native articular chondrocytes, costochondral cells are emerging as a suitable cell source. Looking forward, additional cell sources are investigated to render these technologies more translatable. For example, dermis isolated adult stem (DIAS) cells show potential as a source of

  8. Operational Based Vision Assessment Automated Vision Test Collection User Guide

    Science.gov (United States)

    2017-05-15

    AFRL-SA-WP-SR-2017-0012 Operational Based Vision Assessment Automated Vision Test Collection User Guide Elizabeth Shoda, Alex...June 2015 – May 2017 4. TITLE AND SUBTITLE Operational Based Vision Assessment Automated Vision Test Collection User Guide 5a. CONTRACT NUMBER... automated vision tests , or AVT. Development of the AVT was required to support threshold-level vision testing capability needed to investigate the

  9. Computer-Aided Test Flow in Core-Based Design

    OpenAIRE

    Zivkovic, V.; Tangelder, R.J.W.T.; Kerkhoff, Hans G.

    2000-01-01

    This paper copes with the test-pattern generation and fault coverage determination in the core based design. The basic core-test strategy that one has to apply in the core-based design is stated in this work. A Computer-Aided Test (CAT) flow is proposed resulting in accurate fault coverage of embedded cores. The CAT now is applied to a few cores within the Philips Core Test Pilot IC project

  10. Testing for Statistical Discrimination based on Gender

    DEFF Research Database (Denmark)

    Lesner, Rune Vammen

    . It is shown that the implications of both screening discrimination and stereotyping are consistent with observable wage dynamics. In addition, it is found that the gender wage gap decreases in tenure but increases in job transitions and that the fraction of women in high-ranking positions within a firm does......This paper develops a model which incorporates the two most commonly cited strands of the literature on statistical discrimination, namely screening discrimination and stereotyping. The model is used to provide empirical evidence of statistical discrimination based on gender in the labour market...... not affect the level of statistical discrimination by gender....

  11. Comparison of the Clock Test and a questionnaire-based test for ...

    African Journals Online (AJOL)

    Comparison of the Clock Test and a questionnaire-based test for screening for cognitive impairment in Nigerians. D J VanderJagt, S Ganga, M O Obadofin, P Stanley, M Zimmerman, B J Skipper, R H Glew ...

  12. Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity

    Science.gov (United States)

    Charlier, Caroline; Touchon, Marie; Chenal-Francisque, Viviane; Leclercq, Alexandre; Criscuolo, Alexis; Gaultier, Charlotte; Roussel, Sophie; Brisabois, Anne; Disson, Olivier; Rocha, Eduardo P. C.; Brisse, Sylvain; Lecuit, Marc

    2016-01-01

    Microbial pathogenesis studies are typically performed with reference strains, thereby overlooking microbial intra-species virulence heterogeneity. Here we integrated human epidemiological and clinical data with bacterial population genomics to harness the biodiversity of the model foodborne pathogen Listeria monocytogenes and decipher the basis of its neural and placental tropisms. Taking advantage of the clonal structure of this bacterial species, we identify clones epidemiologically associated with either food or human central nervous system (CNS) and maternal-neonatal (MN) listeriosis. The latter are also most prevalent in patients without immunosuppressive comorbidities. Strikingly, CNS and MN clones are hypervirulent in a humanized mouse model of listeriosis. By integrating epidemiological data and comparative genomics, we uncovered multiple novel putative virulence factors and demonstrated experimentally the contribution of the first gene cluster mediating Listeria monocytogenes neural and placental tropisms. This study illustrates the exceptional power of harnessing microbial biodiversity to identify clinically relevant microbial virulence attributes. PMID:26829754

  13. HARNESSING THE CHEMISTRY OF CO2

    Energy Technology Data Exchange (ETDEWEB)

    Louie, Janis

    2010-05-11

    Our research program is broadly focused on activating CO{sub 2} through the use of organic and organometallic based catalysts. Some of our methods have centered on annulation reactions of unsaturated hydrocarbons (and carbonyl substrates) to provide a diverse array of carbocycles and heterocycles. We use a combination of catalyst discovery and optimization in conjunction with classical physical organic chemistry to elucidate the key mechanistic features of the cycloaddition reactions such that the next big advances in catalyst development can be made. Key to all of our cycloaddition reactions is the use of a sterically hindered, electron donating N heterocyclic carbene (NHC) ligand, namely IPr (or SIPr), in conjunction with a low valent nickel pre-catalyst. The efficacy of this ligand is two-fold: (1) the high {delta}-donating ability of the NHC increases the nucleophilicity of the metal center which thereby facilitates interaction with the electrophilic carbonyl and (2) the steric hindrance prevents an otherwise competitive side reaction involving only the alkyne substrate. Such a system has allowed for the facile cycloaddition to prepare highly functionalized pyrones, pyridones, pyrans, as well as novel carbocycles. Importantly, all reactions proceed under extremely mild conditions (room temperature, atmospheric pressures, and short reaction times), require only catalytic amounts of Ni/NHC and readily available starting materials, and afford annulated products in excellent yields. Our current focus revolves around understanding the fundamental processes that govern these cycloadditions such that the next big advance in the cyclization chemistry of CO{sub 2} can be made. Concurrent to our annulation chemistry is our investigation of the potential for imidazolylidenes to function as thermally-actuated CO{sub 2} sequestering and delivery agents.

  14. Testing of advanced chromium - iron based steel

    International Nuclear Information System (INIS)

    Simeg Veternikova, J.; Degmova, J.; Sabelova, V.; Sojak, S.; Petriska, M.; Slugen, V.; Simko, F.; Pekarcikova, M.

    2015-01-01

    Research and Development of advanced nuclear reactors in Generation IV (GEN IV) are limited by the selection of proper construction materials. Suitable candidate materials are still under extensive investigation, because their properties must be excellent to achieve high level of reactor system safety. NF 709 (Fe-20Cr-25Ni) is new austenitic steel with improved properties in compare to AISI steels; therefore it is also one of candidate materials. Our study is focused on investigation of radiation resistance as well as thermal stability of this steel - NF 709. New austenitic steel NF 709, candidate materials for construction of Generation IV reactors, was observed in term of its stability after an exposure to very high temperature and irradiation. The change of microstructure was observed by positron annihilation techniques which demonstrated the growth of vacancy defects from di-vacancies in as-received material to three-vacancies in material after the thermal and implantation treatments; although the total change of structure was very small. Thus, NF 709 showed good resistance to tested strains and according to our preliminary results. Therefore, this material could be used for high temperature applications and interchangeable components of Generation IV reactors. (authors)

  15. Hello World: Harnessing social media for the Rosetta mission

    Science.gov (United States)

    Baldwin, E.; Mignone, C.; O'Flaherty, K. S.; Homfeld, A.-M.; Bauer, M.; McCaughrean, M. J.

    2015-10-01

    The European Space Agency's (ESA) comet-chasing Rosetta mission was launched in 2004, before social media became a popular tool for mainstream communication. By harnessing a range of platforms for communicating the key messages of this unprecedented space adventure as the spacecraft reached its destination ten years later, a wide range of new audiences were reached and could follow this once-in-a-lifetime mission.

  16. Tosprogede har en trumf i ærmet

    DEFF Research Database (Denmark)

    Henriksen, Carsten

    2010-01-01

    Solstrålehistorier om afghanske superstudenter ændrer ikke ved det faktum, at tosprogede børns faglige niveau halter bagefter deres danske klassekammeraters. Vi har brug for at skrue op for den pædagogiske målrettethed og ned for skrækken for andre sprog, hvis vi skal rette op på skævheden, mener...

  17. BEAT: A Web-Based Boolean Expression Fault-Based Test Case Generation Tool

    Science.gov (United States)

    Chen, T. Y.; Grant, D. D.; Lau, M. F.; Ng, S. P.; Vasa, V. R.

    2006-01-01

    BEAT is a Web-based system that generates fault-based test cases from Boolean expressions. It is based on the integration of our several fault-based test case selection strategies. The generated test cases are considered to be fault-based, because they are aiming at the detection of particular faults. For example, when the Boolean expression is in…

  18. Enhanced Harnessing of the Graviola Bioactive Components Using a Neoteric Sonication Cum Microwave Coadjuvant Extraction Protocol

    Directory of Open Access Journals (Sweden)

    Se Chul Chun

    2018-02-01

    Full Text Available Graviola is one of the most accomplished natural anticancer therapists gaining popularity in recent times. Harnessing the full benefit from tapping all of its rich bioactive reservoirs is absolutely worthy and mandatory. It is in this regard that a well optimized extraction methodology gains paramount importance. In case of Graviola, no sophistication in terms of extraction methods is reported. A neoteric sonication cum microwave combined extraction technology was introduced that maximized the extraction process and minimized (7 min the extraction time. The extraction efficiency was validated based on the significant enrichment of bioactive ingredients in Graviola extracts following the sonication cum microwave combined protocol.

  19. Network harness: bundles of routes in public transport networks

    Science.gov (United States)

    Berche, B.; von Ferber, C.; Holovatch, T.

    2009-12-01

    Public transport routes sharing the same grid of streets and tracks are often found to proceed in parallel along shorter or longer sequences of stations. Similar phenomena are observed in other networks built with space consuming links such as cables, vessels, pipes, neurons, etc. In the case of public transport networks (PTNs) this behavior may be easily worked out on the basis of sequences of stations serviced by each route. To quantify this behavior we use the recently introduced notion of network harness. It is described by the harness distribution P(r, s): the number of sequences of s consecutive stations that are serviced by r parallel routes. For certain PTNs that we have analyzed we observe that the harness distribution may be described by power laws. These power laws indicate a certain level of organization and planning which may be driven by the need to minimize the costs of infrastructure and secondly by the fact that points of interest tend to be clustered in certain locations of a city. This effect may be seen as a result of the strong interdependence of the evolutions of both the city and its PTN. To further investigate the significance of the empirical results we have studied one- and two-dimensional models of randomly placed routes modeled by different types of walks. While in one dimension an analytic treatment was successful, the two dimensional case was studied by simulations showing that the empirical results for real PTNs deviate significantly from those expected for randomly placed routes.

  20. Harnessing indigenous knowledge for sustainable forest management in Ghana

    Directory of Open Access Journals (Sweden)

    Margaret Sraku-Lartey

    2015-01-01

    Full Text Available This paper makes a case for harnessing indigenous knowledge (IK for sustainable national development in Ghana. IK according to the World Bank is the basic component of any country’s knowledge system and it is upon this knowledge that scientific research builds. In Ghana the Government has recognized the need to harness IK for sustainable national development and has therefore incorporated it into the National Science, Technology and Innovation Development Programme. But there is no evidence however that scientific research in Ghana actually takes IK into consideration during the research process. This paper discusses the concept of indigenous knowledge, its relevance in scientific discourse and the need for harnessing it for national development in Ghana. A desk study was conducted using journal publications, research and technical reports, online databases and the internet. About sixty articles were analysed using the thematic synthesis method under the following broad headings: Importance of Indigenous knowledge, Indigenous forest foods, Indigenous medicines, IK and food security, the management and processing of IK and the protection of Indigenous Knowledge.The results of the study established the need to document the local knowledge using appropriate procedures and strategies. It also concludes by suggesting that IK in Ghana must be protected by law and integrated into formal science.

  1. DLP™-based dichoptic vision test system

    Science.gov (United States)

    Woods, Russell L.; Apfelbaum, Henry L.; Peli, Eli

    2010-01-01

    It can be useful to present a different image to each of the two eyes while they cooperatively view the world. Such dichoptic presentation can occur in investigations of stereoscopic and binocular vision (e.g., strabismus, amblyopia) and vision rehabilitation in clinical and research settings. Various techniques have been used to construct dichoptic displays. The most common and most flexible modern technique uses liquid-crystal (LC) shutters. When used in combination with cathode ray tube (CRT) displays, there is often leakage of light from the image intended for one eye into the view of the other eye. Such interocular crosstalk is 14% even in our state of the art CRT-based dichoptic system. While such crosstalk may have minimal impact on stereo movie or video game experiences, it can defeat clinical and research investigations. We use micromirror digital light processing (DLP™) technology to create a novel dichoptic visual display system with substantially lower interocular crosstalk (0.3% remaining crosstalk comes from the LC shutters). The DLP system normally uses a color wheel to display color images. Our approach is to disable the color wheel, synchronize the display directly to the computer's sync signal, allocate each of the three (former) color presentations to one or both eyes, and open and close the LC shutters in synchrony with those color events.

  2. Wind turbine blade testing system using base excitation

    Science.gov (United States)

    Cotrell, Jason; Thresher, Robert; Lambert, Scott; Hughes, Scott; Johnson, Jay

    2014-03-25

    An apparatus (500) for fatigue testing elongate test articles (404) including wind turbine blades through forced or resonant excitation of the base (406) of the test articles (404). The apparatus (500) includes a testing platform or foundation (402). A blade support (410) is provided for retaining or supporting a base (406) of an elongate test article (404), and the blade support (410) is pivotally mounted on the testing platform (402) with at least two degrees of freedom of motion relative to the testing platform (402). An excitation input assembly (540) is interconnected with the blade support (410) and includes first and second actuators (444, 446, 541) that act to concurrently apply forces or loads to the blade support (410). The actuator forces are cyclically applied in first and second transverse directions. The test article (404) responds to shaking of its base (406) by oscillating in two, transverse directions (505, 507).

  3. Formal Specification Based Automatic Test Generation for Embedded Network Systems

    Directory of Open Access Journals (Sweden)

    Eun Hye Choi

    2014-01-01

    Full Text Available Embedded systems have become increasingly connected and communicate with each other, forming large-scaled and complicated network systems. To make their design and testing more reliable and robust, this paper proposes a formal specification language called SENS and a SENS-based automatic test generation tool called TGSENS. Our approach is summarized as follows: (1 A user describes requirements of target embedded network systems by logical property-based constraints using SENS. (2 Given SENS specifications, test cases are automatically generated using a SAT-based solver. Filtering mechanisms to select efficient test cases are also available in our tool. (3 In addition, given a testing goal by the user, test sequences are automatically extracted from exhaustive test cases. We’ve implemented our approach and conducted several experiments on practical case studies. Through the experiments, we confirmed the efficiency of our approach in design and test generation of real embedded air-conditioning network systems.

  4. Algorithm of automatic generation of technology process and process relations of automotive wiring harnesses

    Institute of Scientific and Technical Information of China (English)

    XU Benzhu; ZHU Jiman; LIU Xiaoping

    2012-01-01

    Identifying each process and their constraint relations from the complex wiring harness drawings quickly and accurately is the basis for formulating process routes. According to the knowledge of automotive wiring harness and the characteristics of wiring harness components, we established the model of wiring harness graph. Then we research the algorithm of identifying technology processes automatically, finally we describe the relationships between processes by introducing the constraint matrix, which is in or- der to lay a good foundation for harness process planning and production scheduling.

  5. Model-Based GUI Testing Using Uppaal at Novo Nordisk

    Science.gov (United States)

    Hjort, Ulrik H.; Illum, Jacob; Larsen, Kim G.; Petersen, Michael A.; Skou, Arne

    This paper details a collaboration between Aalborg University and Novo Nordiskin developing an automatic model-based test generation tool for system testing of the graphical user interface of a medical device on an embedded platform. The tool takes as input an UML Statemachine model and generates a test suite satisfying some testing criterion, such as edge or state coverage, and converts the individual test case into a scripting language that can be automatically executed against the target. The tool has significantly reduced the time required for test construction and generation, and reduced the number of test scripts while increasing the coverage.

  6. Analysing Test-Takers’ Views on a Computer-Based Speaking Test

    Directory of Open Access Journals (Sweden)

    Marian Amengual-Pizarro

    2017-11-01

    Full Text Available This study examines test-takers’ views on a computer-delivered speaking test in order to investigate the aspects they consider most relevant in technology-based oral assessment, and to explore the main advantages and disadvantages computer-based tests may offer as compared to face-to-face speaking tests. A small-scale open questionnaire was administered to 80 test-takers who took the APTIS speaking test at the Universidad de Alcalá in April 2016. Results reveal that examinees believe computer-based tests provide a valid measure of oral competence in English and are considered to be an adequate method for the assessment of speaking. Interestingly, the data suggest that personal characteristics of test-takers seem to play a key role in deciding upon the most suitable and reliable delivery mode.

  7. Observation-Based Modeling for Model-Based Testing

    NARCIS (Netherlands)

    Kanstrén, T.; Piel, E.; Gross, H.G.

    2009-01-01

    One of the single most important reasons that modeling and modelbased testing are not yet common practice in industry is the perceived difficulty of making the models up to the level of detail and quality required for their automated processing. Models unleash their full potential only through

  8. A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases.

    Directory of Open Access Journals (Sweden)

    Ashley L Waldron

    Full Text Available Histidyl tRNA Synthetase (HARS is a member of the aminoacyl tRNA synthetase (ARS family of enzymes. This family of 20 enzymes is responsible for attaching specific amino acids to their cognate tRNA molecules, a critical step in protein synthesis. However, recent work highlighting a growing number of associations between ARS genes and diverse human diseases raises the possibility of new and unexpected functions in this ancient enzyme family. For example, mutations in HARS have been linked to two different neurological disorders, Usher Syndrome Type IIIB and Charcot Marie Tooth peripheral neuropathy. These connections raise the possibility of previously undiscovered roles for HARS in metazoan development, with alterations in these functions leading to complex diseases. In an attempt to establish Danio rerio as a model for studying HARS functions in human disease, we characterized the Danio rerio hars gene and compared it to that of human HARS. Using a combination of bioinformatics, molecular biology, and cellular approaches, we found that while the human genome encodes separate genes for cytoplasmic and mitochondrial HARS protein, the Danio rerio genome encodes a single hars gene which undergoes alternative splicing to produce the respective cytoplasmic and mitochondrial versions of Hars. Nevertheless, while the HARS genes of humans and Danio differ significantly at the genomic level, we found that they are still highly conserved at the amino acid level, underscoring the potential utility of Danio rerio as a model organism for investigating HARS function and its link to human diseases in vivo.

  9. Heat radiation approach for harnessing heat of the cook stove to generate electricity for lighting system and charging of mobile phone

    Science.gov (United States)

    Muñoz, Rodrigo C., Jr.; Manansala, Chad Deo G.

    2018-01-01

    This study is based on the potential of thermoelectric coupling such as the thermoelectric cooler module. A thermoelectric cooler converts the heat coming from the cook stove into electricity and store in a battery. A dc-dc boost converter will be used to produce enough voltage to light a minimum house dwelling or charge phone battery. This device will be helpful to those that faces a problem on electricity especially in the isolated areas. The study aims (1) to harness heat from the cook stove up to 110 °C (2) To automatically cool-off the system to protect the thermoelectric cooler from damage due to excessive heat using an electronic solenoid; (3) To store energy harnessed in the battery; (4) To amplify the output voltages of the battery using DC to DC boost converter for lighting system and charging of mobile phone battery. From various tests conducted, it can fully charge a mobile phone in 3 hours observing the unit’s battery voltage drop from 4.06V to 3.98V. In the testing it used different orientation of steel rod by conduction to transfer heat and by radiation through tubular steel with its different dimensions. Most recent testing proved that the 2x2x9 tubular steel by radiation had the best result. The temperature reached more than a hundred degree Celsius that met the objective. The test resulted of boosting the voltage of the battery output from 3.7V to 4.96V on the average. The boosted voltage decrease as the system’s cool-off mechanism operated when the temperature reached above 110 degree Celsius decreasing output voltage to 0.8V resulting the boosted voltage to drop to zero. Therefore, the proponents concluded that heat waste can be converted to electrical energy by harnessing heat through radiation, with the help of TEC that generates voltage for lighting and can be boosted to be used for mobile charging. Furthermore, the study proved that the excess heat can damaged the TEC which was prevented by using of cooling-off mechanism, making it more

  10. Moving beyond the Failure of Test-Based Accountability

    Science.gov (United States)

    Koretz, Daniel

    2018-01-01

    In "The Testing Charade: Pretending to Make Schools Better", the author's new book from which this article is drawn, the failures of test-based accountability are documented and some of the most egregious misuses and outright abuses of testing are described, along with some of the most serious negative effects. Neither good intentions…

  11. Ethernet-based test stand for a CAN network

    Science.gov (United States)

    Ziebinski, Adam; Cupek, Rafal; Drewniak, Marek

    2017-11-01

    This paper presents a test stand for the CAN-based systems that are used in automotive systems. The authors propose applying an Ethernet-based test system that supports the virtualisation of a CAN network. The proposed solution has many advantages compared to classical test beds that are based on dedicated CAN-PC interfaces: it allows the physical constraints associated with the number of interfaces that can be simultaneously connected to a tested system to be avoided, which enables the test time for parallel tests to be shortened; the high speed of Ethernet transmission allows for more frequent sampling of the messages that are transmitted by a CAN network (as the authors show in the experiment results section) and the cost of the proposed solution is much lower than the traditional lab-based dedicated CAN interfaces for PCs.

  12. Security Considerations and Recommendations in Computer-Based Testing

    Directory of Open Access Journals (Sweden)

    Saleh M. Al-Saleem

    2014-01-01

    Full Text Available Many organizations and institutions around the globe are moving or planning to move their paper-and-pencil based testing to computer-based testing (CBT. However, this conversion will not be the best option for all kinds of exams and it will require significant resources. These resources may include the preparation of item banks, methods for test delivery, procedures for test administration, and last but not least test security. Security aspects may include but are not limited to the identification and authentication of examinee, the risks that are associated with cheating on the exam, and the procedures related to test delivery to the examinee. This paper will mainly investigate the security considerations associated with CBT and will provide some recommendations for the security of these kinds of tests. We will also propose a palm-based biometric authentication system incorporated with basic authentication system (username/password in order to check the identity and authenticity of the examinee.

  13. Correlations between power and test reactor data bases

    International Nuclear Information System (INIS)

    Guthrie, G.L.; Simonen, E.P.

    1989-02-01

    Differences between power reactor and test reactor data bases have been evaluated. Charpy shift data has been assembled from specimens irradiated in both high-flux test reactors and low-flux power reactors. Preliminary tests for the existence of a bias between test and power reactor data bases indicate a possible bias between the weld data bases. The bias is nonconservative for power predictive purposes, using test reactor data. The lesser shift for test reactor data compared to power reactor data is interpreted primarily in terms of greater point defect recombination for test reactor fluxes compared to power reactor fluxes. The possibility of greater thermal aging effects during lower damage rates is also discussed. 15 refs., 5 figs., 2 tabs

  14. Security considerations and recommendations in computer-based testing.

    Science.gov (United States)

    Al-Saleem, Saleh M; Ullah, Hanif

    2014-01-01

    Many organizations and institutions around the globe are moving or planning to move their paper-and-pencil based testing to computer-based testing (CBT). However, this conversion will not be the best option for all kinds of exams and it will require significant resources. These resources may include the preparation of item banks, methods for test delivery, procedures for test administration, and last but not least test security. Security aspects may include but are not limited to the identification and authentication of examinee, the risks that are associated with cheating on the exam, and the procedures related to test delivery to the examinee. This paper will mainly investigate the security considerations associated with CBT and will provide some recommendations for the security of these kinds of tests. We will also propose a palm-based biometric authentication system incorporated with basic authentication system (username/password) in order to check the identity and authenticity of the examinee.

  15. A comparison of test statistics for the recovery of rapid growth-based enumeration tests

    NARCIS (Netherlands)

    van den Heuvel, Edwin R.; IJzerman-Boon, Pieta C.

    This paper considers five test statistics for comparing the recovery of a rapid growth-based enumeration test with respect to the compendial microbiological method using a specific nonserial dilution experiment. The finite sample distributions of these test statistics are unknown, because they are

  16. Using the noninformative families in family-based association tests : A powerful new testing strategy

    NARCIS (Netherlands)

    Lange, C; DeMeo, D; Silverman, EK; Weiss, ST; Laird, NM

    2003-01-01

    For genetic association studies with multiple phenotypes, we propose a new strategy for multiple testing with family-based association tests (FBATs). The strategy increases the power by both using all available family data and reducing the number of hypotheses tested while being robust against

  17. An isotropic suspension system for a biaxial accelerometer using electroplated thick metal with a HAR SU-8 mold

    International Nuclear Information System (INIS)

    Lee, Jin Seung; Lee, Seung S

    2008-01-01

    In this paper, a novel approach is developed to design an isotropic suspension system using thick metal freestanding micro-structures combining bulk micro-machining with electroplating based on a HAR SU-8 mold. An omega-shape isotropic suspension system composed of circular curved beams that have free switching of imaginary boundary conditions is proposed. This novel isotropic suspension design is not affected by geometric dimensional parameters and always achieves matching stiffness along the principle axes of elasticity. Using the finite element method, the isotropic suspension system was compared with an S-shaped meandering suspension system. In order to realize the suggested isotropic suspension system, a cost-effective fabrication process using electroplating with the SU-8 mold was developed to avoid expensive equipment and materials such as deep reactive-ion etching (DRIE) or a silicon-on-insulator (SOI) wafer. The fabricated isotropic suspension system was verified by electromagnetic actuation experiments. Finally, a biaxial accelerometer with isotropic suspension system was realized and tested using a vibration generator system. The proposed isotropic suspension system and the modified surface micro-machining technique based on electroplating with an SU-8 mold can contribute towards minimizing the system size, simplifying the system configuration, reducing the system price of and facilitating mass production of various types of low-cost sensors and actuators

  18. Geometrical error calibration in reflective surface testing based on reverse Hartmann test

    Science.gov (United States)

    Gong, Zhidong; Wang, Daodang; Xu, Ping; Wang, Chao; Liang, Rongguang; Kong, Ming; Zhao, Jun; Mo, Linhai; Mo, Shuhui

    2017-08-01

    In the fringe-illumination deflectometry based on reverse-Hartmann-test configuration, ray tracing of the modeled testing system is performed to reconstruct the test surface error. Careful calibration of system geometry is required to achieve high testing accuracy. To realize the high-precision surface testing with reverse Hartmann test, a computer-aided geometrical error calibration method is proposed. The aberrations corresponding to various geometrical errors are studied. With the aberration weights for various geometrical errors, the computer-aided optimization of system geometry with iterative ray tracing is carried out to calibration the geometrical error, and the accuracy in the order of subnanometer is achieved.

  19. Cross-Mode Comparability of Computer-Based Testing (CBT) versus Paper-Pencil Based Testing (PPT): An Investigation of Testing Administration Mode among Iranian Intermediate EFL Learners

    Science.gov (United States)

    Khoshsima, Hooshang; Hosseini, Monirosadat; Toroujeni, Seyyed Morteza Hashemi

    2017-01-01

    Advent of technology has caused growing interest in using computers to convert conventional paper and pencil-based testing (Henceforth PPT) into Computer-based testing (Henceforth CBT) in the field of education during last decades. This constant promulgation of computers to reshape the conventional tests into computerized format permeated the…

  20. Effects of harness transmitters on behavior and reproduction of wild mallards

    Science.gov (United States)

    Pietz, Pamela J.; Krapu, Gary L.; Greenwood, Raymond J.; Lokemoen, John T.

    1993-01-01

    Radio telemetry has been an important research tool in waterfowl studies for >20 years, yet little effort has been made to evaluate potential effects of transmitters on the birds that carry them. As part of a 4-year mallard (Anas platyrhynchos) study in the prairie pothole region of North Dakota and Minnesota, we compared radio-marked and unmarked female mallards in terms of percent time observed feeding, resting, and preening; nest initiation date; and clutch size and egg volume. Radio-marked females carried a 23-g back-mounted transmitter attached with a 2-loop harness (Dwyer 1972). On average, radio-marked females tended to feed less, rest and preen more, initiate nests later, and lay smaller clutches and eggs than unmarked females. Thus, behavioral and reproductive data from ducks marked with back-mounted harness-attached transmitters may be biased. We recommend that new designs of radio packages be field tested and caution that effects may be masked under extreme environmental conditions.

  1. "Hello, World!" Harnessing Social Media for the Rosetta Mission

    Science.gov (United States)

    Baldwin, E.; Mignone, C.; Scuka, D.; Homfeld, A. M.; Ranero, K.; Rolfe, E.; Bennett, M.; Schepers, A.; O'Flaherty, K. S.; Bauer, M.; McCaughrean, M.

    2016-03-01

    The European Space Agency's comet-chasing Rosetta mission was launched in 2004, before social media became a popular tool for mainstream communication. As it reached its destination ten years later, new audiences were reached and inspired by this once-in-a-lifetime event by harnessing a range of outlets for communicating the key messages. These included traditional online platforms, such as news websites, blogs, and Livestream, as well as Twitter, Facebook, Instagram, Flickr, YouTube, Google+ and SoundCloud. In this article, we outline the role social media channels played in making Rosetta one of the European Space Agency's biggest communication and public engagement successes.

  2. When sparks fly harnessing the power of group creativity

    CERN Document Server

    Leonard, Dorothy

    2005-01-01

    Creativity and innovation are evergreen topics. Particularly in today's tough marketplace, companies in every industry are looking for ways to harness creativity and innovation to spur growth and enhance competitiveness. This book differs from many books on creativity in that its focus is on how to manage a group, rather than individual creativity. It refutes much conventional wisdom about where creativity comes from, particularly that creativity does not stem from the random genius of individuals. The authors reveal specific group configurations and strategies that can unleash the collective creativity of any team or group.

  3. Harnessing natural product assembly lines: structure, promiscuity, and engineering.

    Science.gov (United States)

    Ladner, Christopher C; Williams, Gavin J

    2016-03-01

    Many therapeutically relevant natural products are biosynthesized by the action of giant mega-enzyme assembly lines. By leveraging the specificity, promiscuity, and modularity of assembly lines, a variety of strategies has been developed that enables the biosynthesis of modified natural products. This review briefly summarizes recent structural advances related to natural product assembly lines, discusses chemical approaches to probing assembly line structures in the absence of traditional biophysical data, and surveys efforts that harness the inherent or engineered promiscuity of assembly lines for the synthesis of non-natural polyketides and non-ribosomal peptide analogues.

  4. Model Based Analysis and Test Generation for Flight Software

    Science.gov (United States)

    Pasareanu, Corina S.; Schumann, Johann M.; Mehlitz, Peter C.; Lowry, Mike R.; Karsai, Gabor; Nine, Harmon; Neema, Sandeep

    2009-01-01

    We describe a framework for model-based analysis and test case generation in the context of a heterogeneous model-based development paradigm that uses and combines Math- Works and UML 2.0 models and the associated code generation tools. This paradigm poses novel challenges to analysis and test case generation that, to the best of our knowledge, have not been addressed before. The framework is based on a common intermediate representation for different modeling formalisms and leverages and extends model checking and symbolic execution tools for model analysis and test case generation, respectively. We discuss the application of our framework to software models for a NASA flight mission.

  5. Towards model-based testing of electronic funds transfer systems

    OpenAIRE

    Asaadi, H.R.; Khosravi, R.; Mousavi, M.R.; Noroozi, N.

    2010-01-01

    We report on our first experience with applying model-based testing techniques to an operational Electronic Funds Transfer (EFT) switch. The goal is to test the conformance of the EFT switch to the standard flows described by the ISO 8583 standard. To this end, we first make a formalization of the transaction flows specified in the ISO 8583 standard in terms of a Labeled Transition System (LTS). This formalization paves the way for model-based testing based on the formal notion of Input-Outpu...

  6. Design Of Computer Based Test Using The Unified Modeling Language

    Science.gov (United States)

    Tedyyana, Agus; Danuri; Lidyawati

    2017-12-01

    The Admission selection of Politeknik Negeri Bengkalis through interest and talent search (PMDK), Joint Selection of admission test for state Polytechnics (SB-UMPN) and Independent (UM-Polbeng) were conducted by using paper-based Test (PBT). Paper Based Test model has some weaknesses. They are wasting too much paper, the leaking of the questios to the public, and data manipulation of the test result. This reasearch was Aimed to create a Computer-based Test (CBT) models by using Unified Modeling Language (UML) the which consists of Use Case diagrams, Activity diagram and sequence diagrams. During the designing process of the application, it is important to pay attention on the process of giving the password for the test questions before they were shown through encryption and description process. RSA cryptography algorithm was used in this process. Then, the questions shown in the questions banks were randomized by using the Fisher-Yates Shuffle method. The network architecture used in Computer Based test application was a client-server network models and Local Area Network (LAN). The result of the design was the Computer Based Test application for admission to the selection of Politeknik Negeri Bengkalis.

  7. PLC based control system for RAM assembly test facility

    International Nuclear Information System (INIS)

    Kulkarni, S.S.; Kumar, Vinaya; Chandra, Umesh

    1994-01-01

    The flexibility, expandability, ease of programming and diagnostic features makes the programmable logic controller (PLC) suitable for a variety of control applications in engineering system test facilities. A PLC based control system for RAM assembly test facility (RATF) and for testing the related hydraulic components is being developed and installed at BARC. This paper describes the approach taken for meeting the control requirements and illustrates the PLC software that has been developed. (author). 1 fig

  8. Functions and Design Scheme of Tibet High Altitude Test Base

    Institute of Scientific and Technical Information of China (English)

    Yu Yongqing; Guo Jian; Yin Yu; Mao Yan; Li Guangfan; Fan Jianbin; Lu Jiayu; Su Zhiyi; Li Peng; Li Qingfeng; Liao Weiming; Zhou Jun

    2010-01-01

    @@ The functional orientation of the Tibet High Altitude Test Base, subordinated to the State Grid Corporation of China (SGCC), is to serve power transmission projects in high altitude areas, especially to provide technical support for southwestern hydropower delivery projects by UHVDC transmission and Qinghai-Tibet grid interconnection project. This paper presents the matters concerned during siting and planning, functions,design scheme, the main performances and parameters of the test facilities, as well as the tests and research tasks already carried out.

  9. A LabVIEWTM-based detector testing system

    International Nuclear Information System (INIS)

    Yang Haori; Li Yuanjing; Wang Yi; Li Yulan; Li Jin

    2003-01-01

    The construction of a LabVIEW-based detector testing system is described in this paper. In this system, the signal of detector is magnified and digitized, so amplitude or time spectrum can be obtained. The Analog-to-Digital Converter is a peak-sensitive ADC based on VME bus. The virtual instrument constructed by LabVIEW can be used to acquire data, draw spectrum and save testing results

  10. Home-based HIV counselling and testing in Western Kenya ...

    African Journals Online (AJOL)

    Home-based HIV counselling and testing was feasible among this rural population in western Kenya, with a majority of the population accepting to get tested. These data suggest that scaling-up of HBCT is possible and may enable large numbers of individuals to know their HIV serostatus in sub-Saharan Africa.

  11. Model-Based GUI Testing Using Uppaal at Novo Nordisk

    DEFF Research Database (Denmark)

    H. Hjort, Ulrik; Rasmussen, Jacob Illum; Larsen, Kim Guldstrand

    2009-01-01

    This paper details a collaboration between Aalborg University and Novo Nordiskin developing an automatic model-based test generation tool for system testing of the graphical user interface of a medical device on an embedded platform. The tool takes as input an UML Statemachine model and generates...

  12. Automated model-based testing of hybrid systems

    NARCIS (Netherlands)

    Osch, van M.P.W.J.

    2009-01-01

    In automated model-based input-output conformance testing, tests are automati- cally generated from a speci¯cation and automatically executed on an implemen- tation. Input is applied to the implementation and output is observed from the implementation. If the observed output is allowed according to

  13. Towards model-based testing of electronic funds transfer systems

    NARCIS (Netherlands)

    Asaadi, H.R.; Khosravi, R.; Mousavi, M.R.; Noroozi, N.; Arbab, F.; Sirjani, M.

    2012-01-01

    We report on our first experience with applying model-based testing techniques to an operational Electronic Funds Transfer (EFT) switch. The goal is to test the conformance of the EFT switch to the standard flows described by the ISO 8583 standard. To this end, we first make a formalization of the

  14. Towards model-based testing of electronic funds transfer systems

    NARCIS (Netherlands)

    Asaadi, H.R.; Khosravi, R.; Mousavi, M.R.; Noroozi, N.

    2010-01-01

    We report on our first experience with applying model-based testing techniques to an operational Electronic Funds Transfer (EFT) switch. The goal is to test the conformance of the EFT switch to the standard flows described by the ISO 8583 standard. To this end, we first make a formalization of the

  15. Conceptualizing Teaching to the Test under Standards-Based Reform

    Science.gov (United States)

    Welsh, Megan E.; Eastwood, Melissa; D'Agostino, Jerome V.

    2014-01-01

    Teacher and school accountability systems based on high-stakes tests are ubiquitous throughout the United States and appear to be growing as a catalyst for reform. As a result, educators have increased the proportion of instructional time devoted to test preparation. Although guidelines for what constitutes appropriate and inappropriate test…

  16. Microcomputer based test system for charge coupled devices

    International Nuclear Information System (INIS)

    Sidman, S.

    1981-02-01

    A microcomputer based system for testing analog charge coupled integrated circuits has been developed. It measures device performance for three parameters: dynamic range, baseline shift due to leakage current, and transfer efficiency. A companion board tester has also been developed. The software consists of a collection of BASIC and assembly language routines developed on the test system microcomputer

  17. Defect-based testing of LTS digital circuits

    NARCIS (Netherlands)

    Arun, A.J.

    2006-01-01

    A Defect-Based Test (DBT) methodology for Superconductor Electronics (SCE) is presented in this thesis, so that commercial production and efficient testing of systems can be implemented in this technology in the future. In the first chapter, the features and prospects for SCE have been presented.

  18. To harness, transport and store the CO2

    International Nuclear Information System (INIS)

    Anon.

    2009-01-01

    This article about the CO 2 sequestration is divided in eight parts. The first part concerns the question of why it is important to harness the carbon dioxide. The second part reviews the different technologies to harness it. In part three, the conditioning and transport of CO 2 are studied. Then, the question of geological storage is tackled. The economical aspect of the CO 2 sequestration makes the following part. The acceptability of a underground storage is evoked because of the risk relative to the CO 2 storage. Some examples and projects (Usa, Canada, France) are presented. The conclusion ends this article with the assurance that the CO 2 sequestration is possible, but expansive on the energy level and financing (double investment cost and increasing at least 30% for the production costs for the energy coming from coal). It should be realized on a big scale only if significant tax are imposed to the atmospheric releases in CO 2 as it is the case in the Norwegian example (Sleipner field). The storage potentials are important by calling for aquifer layers. The questions of law and acceptability by the public are uncertain but not insurmountable if we think to the aquifers under the seas. (N.C.)

  19. Uncertainty management in knowledge based systems for nondestructive testing-an example from ultrasonic testing

    International Nuclear Information System (INIS)

    Rajagopalan, C.; Kalyanasundaram, P.; Baldev Raj

    1996-01-01

    The use of fuzzy logic, as a framework for uncertainty management, in a knowledge-based system (KBS) for ultrasonic testing of austenitic stainless steels is described. Parameters that may contain uncertain values are identified. Methodologies to handle uncertainty in these parameters using fuzzy logic are detailed. The overall improvement in the performance of the knowledge-based system after incorporating fuzzy logic is discussed. The methodology developed being universal, its extension to other KBS for nondestructive testing and evaluation is highlighted. (author)

  20. HEV Test Bench Based on CAN Bus Sensor Communication

    Directory of Open Access Journals (Sweden)

    Shupeng ZHAO

    2014-02-01

    Full Text Available The HEV test bench based on Controller Area Network bus was studied and developed. Control system of HEV power test bench used the CAN bus technology. The application of CAN bus technology on control system development has opened up a new research direction for domestic automobile experimental platform. The HEV power control system development work was completed, including power master controller, electric throttle controller, driving simulation platform, CAN2.0 B communication protocol procedures for formulation, CAN communication monitoring system, the simulation model based on MATLAB code automatic generation technology research, etc. Maximum absorption power of the test bench is 90 kW, the test bench top speed is 6000 r/min, the CAN communication data baud rate is 10~500 k, the conventional electric measurement parameter part precision satisfies the requirement of development of HEV. On the HEV test bench the result of regenerative braking experiment shows that the result got by the test bench was closer to the results got by outdoor road test. And the fuel consumption experiment test results show that the HEV fuel consumption and the charge-discharge character are in linear relationship. The establishment of the test platform for the evaluation of the development of hybrid electric vehicle and power provides physical simulation and test platform.

  1. Space Launch System Base Heating Test: Experimental Operations & Results

    Science.gov (United States)

    Dufrene, Aaron; Mehta, Manish; MacLean, Matthew; Seaford, Mark; Holden, Michael

    2016-01-01

    NASA's Space Launch System (SLS) uses four clustered liquid rocket engines along with two solid rocket boosters. The interaction between all six rocket exhaust plumes will produce a complex and severe thermal environment in the base of the vehicle. This work focuses on a recent 2% scale, hot-fire SLS base heating test. These base heating tests are short-duration tests executed with chamber pressures near the full-scale values with gaseous hydrogen/oxygen engines and RSRMV analogous solid propellant motors. The LENS II shock tunnel/Ludwieg tube tunnel was used at or near flight duplicated conditions up to Mach 5. Model development was based on the Space Shuttle base heating tests with several improvements including doubling of the maximum chamber pressures and duplication of freestream conditions. Test methodology and conditions are presented, and base heating results from 76 runs are reported in non-dimensional form. Regions of high heating are identified and comparisons of various configuration and conditions are highlighted. Base pressure and radiometer results are also reported.

  2. On school choice and test-based accountability.

    Directory of Open Access Journals (Sweden)

    Damian W. Betebenner

    2005-10-01

    Full Text Available Among the two most prominent school reform measures currently being implemented in The United States are school choice and test-based accountability. Until recently, the two policy initiatives remained relatively distinct from one another. With the passage of the No Child Left Behind Act of 2001 (NCLB, a mutualism between choice and accountability emerged whereby school choice complements test-based accountability. In the first portion of this study we present a conceptual overview of school choice and test-based accountability and explicate connections between the two that are explicit in reform implementations like NCLB or implicit within the market-based reform literature in which school choice and test-based accountability reside. In the second portion we scrutinize the connections, in particular, between school choice and test-based accountability using a large western school district with a popular choice system in place. Data from three sources are combined to explore the ways in which school choice and test-based accountability draw on each other: state assessment data of children in the district, school choice data for every participating student in the district choice program, and a parental survey of both participants and non-participants of choice asking their attitudes concerning the use of school report cards in the district. Results suggest that choice is of benefit academically to only the lowest achieving students, choice participation is not uniform across different ethnic groups in the district, and parents' primary motivations as reported on a survey for participation in choice are not due to test scores, though this is not consistent with choice preferences among parents in the district. As such, our results generally confirm the hypotheses of choice critics more so than advocates. Keywords: school choice; accountability; student testing.

  3. Efficient p-value evaluation for resampling-based tests

    KAUST Repository

    Yu, K.

    2011-01-05

    The resampling-based test, which often relies on permutation or bootstrap procedures, has been widely used for statistical hypothesis testing when the asymptotic distribution of the test statistic is unavailable or unreliable. It requires repeated calculations of the test statistic on a large number of simulated data sets for its significance level assessment, and thus it could become very computationally intensive. Here, we propose an efficient p-value evaluation procedure by adapting the stochastic approximation Markov chain Monte Carlo algorithm. The new procedure can be used easily for estimating the p-value for any resampling-based test. We show through numeric simulations that the proposed procedure can be 100-500 000 times as efficient (in term of computing time) as the standard resampling-based procedure when evaluating a test statistic with a small p-value (e.g. less than 10( - 6)). With its computational burden reduced by this proposed procedure, the versatile resampling-based test would become computationally feasible for a much wider range of applications. We demonstrate the application of the new method by applying it to a large-scale genetic association study of prostate cancer.

  4. Development of a new test method for Mineral Based Composites

    DEFF Research Database (Denmark)

    Täljsten, Björn; Orosz, Katalin

    2008-01-01

    The well-known wedge splitting test, often used for characterizing brittle materials has been modified and adapted to testing MBC-reinforced concrete under splitting load. MBC (Mineral Based Composites) is a newly developed strengthening system for existing concrete structures where FRPs, mainly...... CFRP grids are externally bonded to the concrete surface by means of cementitious bonding agents. Crack development, crack patterns, crack opening displacement (COD) versus splitting load and fracture energy are investigated and evaluated. Development of a suitable test specimen and test setup has been...

  5. Development of seismic technology and reliability based on vibration tests

    International Nuclear Information System (INIS)

    Sasaki, Youichi

    1997-01-01

    This paper deals with some of the vibration tests and investigations on the seismic safety of nuclear power plants (NPPs) in Japan. To ensure the reliability of the seismic safety of nuclear power plants, nuclear power plants in Japan have been designed according to the Technical Guidelines for Aseismic Design of Nuclear Power Plants. This guideline has been developed based on technical date base and findings which were obtained from many vibration tests and investigations. Besides the tests for the guideline, proving tests on seismic reliability of operating nuclear power plants equipment and systems have been carried out. In this paper some vibration tests and their evaluation results are presented. They have crucially contributed to develop the guideline. (J.P.N.)

  6. Web based aphasia test using service oriented architecture (SOA)

    International Nuclear Information System (INIS)

    Voos, J A; Vigliecca, N S; Gonzalez, E A

    2007-01-01

    Based on an aphasia test for Spanish speakers which analyze the patient's basic resources of verbal communication, a web-enabled software was developed to automate its execution. A clinical database was designed as a complement, in order to evaluate the antecedents (risk factors, pharmacological and medical backgrounds, neurological or psychiatric symptoms, brain injury -anatomical and physiological characteristics, etc) which are necessary to carry out a multi-factor statistical analysis in different samples of patients. The automated test was developed following service oriented architecture and implemented in a web site which contains a tests suite, which would allow both integrating the aphasia test with other neuropsychological instruments and increasing the available site information for scientific research. The test design, the database and the study of its psychometric properties (validity, reliability and objectivity) were made in conjunction with neuropsychological researchers, who participate actively in the software design, based on the patients or other subjects of investigation feedback

  7. Development of seismic technology and reliability based on vibration tests

    Energy Technology Data Exchange (ETDEWEB)

    Sasaki, Youichi [Nuclear Power Engineering Corp., Tokyo (Japan)

    1997-03-01

    This paper deals with some of the vibration tests and investigations on the seismic safety of nuclear power plants (NPPs) in Japan. To ensure the reliability of the seismic safety of nuclear power plants, nuclear power plants in Japan have been designed according to the Technical Guidelines for Aseismic Design of Nuclear Power Plants. This guideline has been developed based on technical date base and findings which were obtained from many vibration tests and investigations. Besides the tests for the guideline, proving tests on seismic reliability of operating nuclear power plants equipment and systems have been carried out. In this paper some vibration tests and their evaluation results are presented. They have crucially contributed to develop the guideline. (J.P.N.)

  8. Web based aphasia test using service oriented architecture (SOA)

    Energy Technology Data Exchange (ETDEWEB)

    Voos, J A [Clinical Engineering R and D Center, Universidad Tecnologica Nacional, Facultad Regional Cordoba, Cordoba (Argentina); Vigliecca, N S [Consejo Nacional de Investigaciones Cientificas y Tecnicas, CONICET, Cordoba (Argentina); Gonzalez, E A [Clinical Engineering R and D Center, Universidad Tecnologica Nacional, Facultad Regional Cordoba, Cordoba (Argentina)

    2007-11-15

    Based on an aphasia test for Spanish speakers which analyze the patient's basic resources of verbal communication, a web-enabled software was developed to automate its execution. A clinical database was designed as a complement, in order to evaluate the antecedents (risk factors, pharmacological and medical backgrounds, neurological or psychiatric symptoms, brain injury -anatomical and physiological characteristics, etc) which are necessary to carry out a multi-factor statistical analysis in different samples of patients. The automated test was developed following service oriented architecture and implemented in a web site which contains a tests suite, which would allow both integrating the aphasia test with other neuropsychological instruments and increasing the available site information for scientific research. The test design, the database and the study of its psychometric properties (validity, reliability and objectivity) were made in conjunction with neuropsychological researchers, who participate actively in the software design, based on the patients or other subjects of investigation feedback.

  9. MATT: Multi Agents Testing Tool Based Nets within Nets

    Directory of Open Access Journals (Sweden)

    Sara Kerraoui

    2016-12-01

    As part of this effort, we propose a model based testing approach for multi agent systems based on such a model called Reference net, where a tool, which aims to providing a uniform and automated approach is developed. The feasibility and the advantage of the proposed approach are shown through a short case study.

  10. Evolution of a Computer-Based Testing Laboratory

    Science.gov (United States)

    Moskal, Patrick; Caldwell, Richard; Ellis, Taylor

    2009-01-01

    In 2003, faced with increasing growth in technology-based and large-enrollment courses, the College of Business Administration at the University of Central Florida opened a computer-based testing lab to facilitate administration of course examinations. Patrick Moskal, Richard Caldwell, and Taylor Ellis describe the development and evolution of the…

  11. Test-Access Planning and Test Scheduling for Embedded Core-Based System Chips

    OpenAIRE

    Goel, Sandeep Kumar

    2005-01-01

    Advances in the semiconductor process technology enable the creation of a complete system on one single die, the so-called system chip or SOC. To reduce time-to-market for large SOCs, reuse of pre-designed and pre-veried blocks called cores is employed. Like the design style, testing of SOCs can be best approached in a core-based fashion. In order to enable core-based test development, an embedded core should be isolated from its surrounding circuitry and electrical test access from chip pins...

  12. Modeling H-ARS using hematological parameters: a comparison between the non-human primate and mini-pig

    International Nuclear Information System (INIS)

    Bolduc, David L.; Buenger, Rolf; Moroni, Maria; Blakely, William F.

    2016-01-01

    Multiple hematological biomarkers (i.e. complete blood counts and serum chemistry parameters) were used in a multivariate linear-regression fit to create predictive algorithms for estimating the severity of hematopoietic acute radiation syndrome (H-ARS) using two different species (i.e. Goettingen Mini-pig and non-human primate (NHP) (Macacca mulatta)). Biomarker data were analyzed prior to irradiation and between 1-60 days (mini-pig) and 1-30 days (NHP) after irradiation exposures of 1.6-3.5 Gy (mini-pig) and 6.5 Gy (NHP) 60 Co gamma ray doses at 0.5-0.6 Gy min -1 and 0.4 Gy min -1 , respectively. Fitted radiation risk and injury categorization (RRIC) values and RRIC prediction percent accuracies were compared between the two models. Both models estimated H-ARS severity with over 80% overall predictive power and with receiver operating characteristic curve area values of 0.884 and 0.825. These results based on two animal radiation models support the concept for the use of a hematopoietic-based algorithm for predicting the risk of H-ARS in humans. (authors)

  13. Frequency of Testing for Dyslipidemia: An Evidence-Based Analysis

    Science.gov (United States)

    2014-01-01

    Background Dyslipidemias include high levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides and low levels of high-density lipoprotein (HDL) cholesterol. Dyslipidemia is a risk factor for cardiovascular disease, which is a major contributor to mortality in Canada. Approximately 23% of the 2009/11 Canadian Health Measures Survey (CHMS) participants had a high level of LDL cholesterol, with prevalence increasing with age, and approximately 15% had a total cholesterol to HDL ratio above the threshold. Objectives To evaluate the frequency of lipid testing in adults not diagnosed with dyslipidemia and in adults on treatment for dyslipidemia. Research Methods A systematic review of the literature set out to identify randomized controlled trials (RCTs), systematic reviews, health technology assessments (HTAs), and observational studies published between January 1, 2000, and November 29, 2012, that evaluated the frequency of testing for dyslipidemia in the 2 populations. Results Two observational studies assessed the frequency of lipid testing, 1 in individuals not on lipid-lowering medications and 1 in treated individuals. Both studies were based on previously collected data intended for a different objective and, therefore, no conclusions could be reached about the frequency of testing at intervals other than the ones used in the original studies. Given this limitation and generalizability issues, the quality of evidence was considered very low. No evidence for the frequency of lipid testing was identified in the 2 HTAs included. Canadian and international guidelines recommend testing for dyslipidemia in individuals at an increased risk for cardiovascular disease. The frequency of testing recommended is based on expert consensus. Conclusions Conclusions on the frequency of lipid testing could not be made based on the 2 observational studies. Current guidelines recommend lipid testing in adults with increased cardiovascular risk, with

  14. Test of cold asphalt storability based on alternative approaches

    Science.gov (United States)

    Abaffyová, Zora; Komačka, Jozef

    2017-09-01

    Cold asphalt products for potholes repairs should be workable (soft enough) for long time to ensure their applicability. Storability is assessed indirectly using various tests of workability. Therefore, simple test methods (self-compaction and disintegration test) was developed and verified to investigate changes of storability of this group of cold asphalts. Selfcompaction of the tested mixture in the upturned Abram’s cone for the cement concrete slump test and in the mould for the California Bearing Ratio test was assessed in first stage. After that the video record of disintegration test was taken. During this test, the mould was lifted up and the mixture fell off the mould (Abram’s cone) or disintegrate (CBR mould). The drop of surface after 10 min self-compaction and netto time related to falling out or disintegration of the mixture were used to evaluate the mixture from storability point of view. It was found out the self-compaction test has not a potential to reveal and prove changes of mixture properties. Based on the disintegration test results it can be stated this test at 5 °C using the upturned Abram’s cone could be a suitable approach to determine qualitative changes of a cold mixture from storability point of view.

  15. Moisture distribution in sludges based on different testing methods

    Institute of Scientific and Technical Information of China (English)

    Wenyi Deng; Xiaodong Li; Jianhua Yan; Fei Wang; Yong Chi; Kefa Cen

    2011-01-01

    Moisture distributions in municipal sewage sludge, printing and dyeing sludge and paper mill sludge were experimentally studied based on four different methods, i.e., drying test, thermogravimetric-differential thermal analysis (TG-DTA) test, thermogravimetricdifferential scanning calorimetry (TG-DSC) test and water activity test. The results indicated that the moistures in the mechanically dewatered sludges were interstitial water, surface water and bound water. The interstitial water accounted for more than 50% wet basis (wb) of the total moisture content. The bond strength of sludge moisture increased with decreasing moisture content, especially when the moisture content was lower than 50% wb. Furthermore, the comparison among the four different testing methods was presented.The drying test was advantaged by its ability to quantify free water, interstitial water, surface water and bound water; while TG-DSC test, TG-DTA test and water activity test were capable of determining the bond strength of moisture in sludge. It was found that the results from TG-DSC and TG-DTA test are more persuasive than water activity test.

  16. Testing ESL sociopragmatics development and validation of a web-based test battery

    CERN Document Server

    Roever, Carsten; Elder, Catherine

    2014-01-01

    Testing of second language pragmatics has grown as a research area but still suffers from a tension between construct coverage and practicality. In this book, the authors describe the development and validation of a web-based test of second language pragmatics for learners of English. The test has a sociopragmatic orientation and strives for a broad coverage of the construct by assessing learners'' metapragmatic judgments as well as their ability to co-construct discourse. To ensure practicality, the test is delivered online and is scored partially automatically and partially by human raters.

  17. Testing Game-Based Performance in Team-Handball.

    Science.gov (United States)

    Wagner, Herbert; Orwat, Matthias; Hinz, Matthias; Pfusterschmied, Jürgen; Bacharach, David W; von Duvillard, Serge P; Müller, Erich

    2016-10-01

    Wagner, H, Orwat, M, Hinz, M, Pfusterschmied, J, Bacharach, DW, von Duvillard, SP, and Müller, E. Testing game-based performance in team-handball. J Strength Cond Res 30(10): 2794-2801, 2016-Team-handball is a fast paced game of defensive and offensive action that includes specific movements of jumping, passing, throwing, checking, and screening. To date and to the best of our knowledge, a game-based performance test (GBPT) for team-handball does not exist. Therefore, the aim of this study was to develop and validate such a test. Seventeen experienced team-handball players performed 2 GBPTs separated by 7 days between each test, an incremental treadmill running test, and a team-handball test game (TG) (2 × 20 minutes). Peak oxygen uptake (V[Combining Dot Above]O2peak), blood lactate concentration (BLC), heart rate (HR), sprinting time, time of offensive and defensive actions as well as running intensities, ball velocity, and jump height were measured in the game-based test. Reliability of the tests was calculated using an intraclass correlation coefficient (ICC). Additionally, we measured V[Combining Dot Above]O2peak in the incremental treadmill running test and BLC, HR, and running intensities in the team-handball TG to determine the validity of the GBPT. For the test-retest reliability, we found an ICC >0.70 for the peak BLC and HR, mean offense and defense time, as well as ball velocity that yielded an ICC >0.90 for the V[Combining Dot Above]O2peak in the GBPT. Percent walking and standing constituted 73% of total time. Moderate (18%) and high (9%) intensity running in the GBPT was similar to the team-handball TG. Our results indicated that the GBPT is a valid and reliable test to analyze team-handball performance (physiological and biomechanical variables) under conditions similar to competition.

  18. Does the Test Work? Evaluating a Web-Based Language Placement Test

    Science.gov (United States)

    Long, Avizia Y.; Shin, Sun-Young; Geeslin, Kimberly; Willis, Erik W.

    2018-01-01

    In response to the need for examples of test validation from which everyday language programs can benefit, this paper reports on a study that used Bachman's (2005) assessment use argument (AUA) framework to examine evidence to support claims made about the intended interpretations and uses of scores based on a new web-based Spanish language…

  19. Qualitative tests for the determination of inorganic bases

    OpenAIRE

    Založnik, Urša

    2013-01-01

    The unit on acids, bases and salts is dealt with in primary and secondary schools and can be very interesting to students because they encounter these substances on an everyday basis. In my Diploma thesis I will focus on bases, especially on how the students could determine in the most interesting way whether a solution is acid or base and which solution (base) that actually is. My goal is to develop simple qualitative tests to determine inorganic bases in primary schools. In nature, ba...

  20. Automated Functional Testing based on the Navigation of Web Applications

    Directory of Open Access Journals (Sweden)

    Boni García

    2011-08-01

    Full Text Available Web applications are becoming more and more complex. Testing such applications is an intricate hard and time-consuming activity. Therefore, testing is often poorly performed or skipped by practitioners. Test automation can help to avoid this situation. Hence, this paper presents a novel approach to perform automated software testing for web applications based on its navigation. On the one hand, web navigation is the process of traversing a web application using a browser. On the other hand, functional requirements are actions that an application must do. Therefore, the evaluation of the correct navigation of web applications results in the assessment of the specified functional requirements. The proposed method to perform the automation is done in four levels: test case generation, test data derivation, test case execution, and test case reporting. This method is driven by three kinds of inputs: i UML models; ii Selenium scripts; iii XML files. We have implemented our approach in an open-source testing framework named Automatic Testing Platform. The validation of this work has been carried out by means of a case study, in which the target is a real invoice management system developed using a model-driven approach.

  1. Exploring pharmacy and home-based sexually transmissible infection testing.

    Science.gov (United States)

    Habel, Melissa A; Scheinmann, Roberta; Verdesoto, Elizabeth; Gaydos, Charlotte; Bertisch, Maggie; Chiasson, Mary Ann

    2015-11-01

    Background This study assessed the feasibility and acceptability of pharmacy and home-based sexually transmissible infection (STI) screening as alternate testing venues among emergency contraception (EC) users. The study included two phases in February 2011-July 2012. In Phase I, customers purchasing EC from eight pharmacies in Manhattan received vouchers for free STI testing at onsite medical clinics. In Phase II, three Facebook ads targeted EC users to connect them with free home-based STI test kits ordered online. Participants completed a self-administered survey. Only 38 participants enrolled in Phase I: 90% female, ≤29 years (74%), 45% White non-Hispanic and 75% college graduates; 71% were not tested for STIs in the past year and 68% reported a new partner in the past 3 months. None tested positive for STIs. In Phase II, ads led to >45000 click-throughs, 382 completed the survey and 290 requested kits; 28% were returned. Phase II participants were younger and less educated than Phase I participants; six tested positive for STIs. Challenges included recruitment, pharmacy staff participation, advertising with discretion and cost. This study found low uptake of pharmacy and home-based testing among EC users; however, STI testing in these settings is feasible and the acceptability findings indicate an appeal among younger women for testing in non-traditional settings. Collaborating with and training pharmacy and medical staff are key elements of service provision. Future research should explore how different permutations of expanding screening in non-traditional settings could improve testing uptake and detect additional STI cases.

  2. Wind turbine blades for harnessing energy from Malaysian low speed wind - manufacturing technique

    International Nuclear Information System (INIS)

    Abas Abd Wahab; Azmin Shakrine

    2000-01-01

    Blades for wind turbine to harness energy in the Malaysia low speed winds have been designed. During wind tunnel testing, wind turbine model using this type of blades has cut in speed of 1.5 m/s and turned at 450 rpm at 4 m/s wind. The blades, due to their critical dimensions of 1.2 m length, 5 cm thickness, tapered and 15 degree twist, were difficult to produce especially in large number. Several production methods have been studied but for economical mass production, fibreglass blades using CNC cutting mould were chosen. The blade and mould designs and the manufacturing processes are briefly outlined in this paper. (Author)

  3. Worldwide Research, Worldwide Participation: Web-Based Test Logger

    Science.gov (United States)

    Clark, David A.

    1998-01-01

    Thanks to the World Wide Web, a new paradigm has been born. ESCORT (steady state data system) facilities can now be configured to use a Web-based test logger, enabling worldwide participation in tests. NASA Lewis Research Center's new Web-based test logger for ESCORT automatically writes selected test and facility parameters to a browser and allows researchers to insert comments. All data can be viewed in real time via Internet connections, so anyone with a Web browser and the correct URL (universal resource locator, or Web address) can interactively participate. As the test proceeds and ESCORT data are taken, Web browsers connected to the logger are updated automatically. The use of this logger has demonstrated several benefits. First, researchers are free from manual data entry and are able to focus more on the tests. Second, research logs can be printed in report format immediately after (or during) a test. And finally, all test information is readily available to an international public.

  4. OCL-BASED TEST CASE GENERATION USING CATEGORY PARTITIONING METHOD

    Directory of Open Access Journals (Sweden)

    A. Jalila

    2015-10-01

    Full Text Available The adoption of fault detection techniques during initial stages of software development life cycle urges to improve reliability of a software product. Specification-based testing is one of the major criterions to detect faults in the requirement specification or design of a software system. However, due to the non-availability of implementation details, test case generation from formal specifications become a challenging task. As a novel approach, the proposed work presents a methodology to generate test cases from OCL (Object constraint Language formal specification using Category Partitioning Method (CPM. The experiment results indicate that the proposed methodology is more effective in revealing specification based faults. Furthermore, it has been observed that OCL and CPM form an excellent combination for performing functional testing at the earliest to improve software quality with reduced cost.

  5. Spil har potentiale som motivation for læring

    DEFF Research Database (Denmark)

    Hedegaard, Lars Norup

    En designbaseret empirisk undersøgelse af almindeligt anvendte gamification elementer. Gamification har til formål at skabe fornøjelse, samt en følelse af leg, i ikke-spil miljøer. Grundet en øget brug af gamification på arbejdspladser og i læreprocesser ses området vigtigt at undersøge yderligere....... Projektet søger at belyse, hvordan gamification påvirker motivationen for læring, herunder hvordan almindeligt anvendte spil-elementer og -genrer kan indgå i planlægningen af læringsaktiviteter. Projektet tager omdrejningspunkt i de studerendes oplevede erfaringer, med den antagelse, at intervention i...

  6. Overheating Anomalies during Flight Test Due to the Base Bleeding

    Science.gov (United States)

    Luchinsky, Dmitry; Hafiychuck, Halyna; Osipov, Slava; Ponizhovskaya, Ekaterina; Smelyanskiy, Vadim; Dagostino, Mark; Canabal, Francisco; Mobley, Brandon L.

    2012-01-01

    In this paper we present the results of the analytical and numerical studies of the plume interaction with the base flow in the presence of base out-gassing. The physics-based analysis and CFD modeling of the base heating for single solid rocket motor performed in this research addressed the following questions: what are the key factors making base flow so different from that in the Shuttle [1]; why CFD analysis of this problem reveals small plume recirculation; what major factors influence base temperature; and why overheating was initiated at a given time in the flight. To answer these questions topological analysis of the base flow was performed and Korst theory was used to estimate relative contributions of radiation, plume recirculation, and chemically reactive out-gassing to the base heating. It was shown that base bleeding and small base volume are the key factors contributing to the overheating, while plume recirculation is effectively suppressed by asymmetric configuration of the flow formed earlier in the flight. These findings are further verified using CFD simulations that include multi-species gas environment both in the plume and in the base. Solid particles in the exhaust plume (Al2O3) and char particles in the base bleeding were also included into the simulations and their relative contributions into the base temperature rise were estimated. The results of simulations are in good agreement with the temperature and pressure in the base measured during the test.

  7. Diagnosis of Food Allergy Based on Oral Food Challenge Test

    OpenAIRE

    Komei Ito; Atsuo Urisu

    2009-01-01

    Diagnosis of food allergy should be based on the observation of allergic symptoms after intake of the suspected food. The oral food challenge test (OFC) is the most reliable clinical procedure for diagnosing food allergy. The OFC is also applied for the diagnosis of tolerance of food allergy. The Japanese Society of Pediatric Allergy and Clinical Immunology issued the 'Japanese Pediatric Guideline for Oral Food Challenge Test in Food Allergy 2009' in April 2009, to provide information on a sa...

  8. Towards Automatic Testing of Reference Point Based Interactive Methods

    OpenAIRE

    Ojalehto, Vesa; Podkopaev, Dmitry; Miettinen, Kaisa

    2016-01-01

    In order to understand strengths and weaknesses of optimization algorithms, it is important to have access to different types of test problems, well defined performance indicators and analysis tools. Such tools are widely available for testing evolutionary multiobjective optimization algorithms. To our knowledge, there do not exist tools for analyzing the performance of interactive multiobjective optimization methods based on the reference point approach to communicating ...

  9. A model based security testing method for protocol implementation.

    Science.gov (United States)

    Fu, Yu Long; Xin, Xiao Long

    2014-01-01

    The security of protocol implementation is important and hard to be verified. Since the penetration testing is usually based on the experience of the security tester and the specific protocol specifications, a formal and automatic verification method is always required. In this paper, we propose an extended model of IOLTS to describe the legal roles and intruders of security protocol implementations, and then combine them together to generate the suitable test cases to verify the security of protocol implementation.

  10. Validation test case generation based on safety analysis ontology

    International Nuclear Information System (INIS)

    Fan, Chin-Feng; Wang, Wen-Shing

    2012-01-01

    Highlights: ► Current practice in validation test case generation for nuclear system is mainly ad hoc. ► This study designs a systematic approach to generate validation test cases from a Safety Analysis Report. ► It is based on a domain-specific ontology. ► Test coverage criteria have been defined and satisfied. ► A computerized toolset has been implemented to assist the proposed approach. - Abstract: Validation tests in the current nuclear industry practice are typically performed in an ad hoc fashion. This study presents a systematic and objective method of generating validation test cases from a Safety Analysis Report (SAR). A domain-specific ontology was designed and used to mark up a SAR; relevant information was then extracted from the marked-up document for use in automatically generating validation test cases that satisfy the proposed test coverage criteria; namely, single parameter coverage, use case coverage, abnormal condition coverage, and scenario coverage. The novelty of this technique is its systematic rather than ad hoc test case generation from a SAR to achieve high test coverage.

  11. Realistic evaluation of tester exposure based on Florida testing experience

    International Nuclear Information System (INIS)

    Schreiber, R.A.

    1990-01-01

    This paper reports on a radon decay product exposure model for Florida Certified Radon Measurement Technicians that has been formulated based on the guidance of 10CFR20. This model was used to estimate the exposure of 44 Florida measurement technicians from January through November of 1989. Comparing estimated testing and home exposure shows that 100% of the technicians observed received more exposure in the home than during testing activities. Exposure during normal office hours also exceed testing exposure in 86% of the technicians observed. Health and safety exposure data for radon measurement technicians does not follow the standard concepts of occupational radiation exposure normally accepted in 10CFR20

  12. FARO base case post-test analysis by COMETA code

    Energy Technology Data Exchange (ETDEWEB)

    Annunziato, A.; Addabbo, C. [Joint Research Centre, Ispra (Italy)

    1995-09-01

    The paper analyzes the COMETA (Core Melt Thermal-Hydraulic Analysis) post test calculations of FARO Test L-11, the so-called Base Case Test. The FARO Facility, located at JRC Ispra, is used to simulate the consequences of Severe Accidents in Nuclear Power Plants under a variety of conditions. The COMETA Code has a 6 equations two phase flow field and a 3 phases corium field: the jet, the droplets and the fused-debris bed. The analysis shown that the code is able to pick-up all the major phenomena occurring during the fuel-coolant interaction pre-mixing phase.

  13. Design of Test Wrapper Scan Chain Based on Differential Evolution

    Directory of Open Access Journals (Sweden)

    Aijun Zhu

    2013-08-01

    Full Text Available Integrated Circuit has entered the era of design of the IP-based SoC (System on Chip, which makes the IP core reuse become a key issue. SoC test wrapper design for scan chain is a NP Hard problem, we propose an algorithm based on Differential Evolution (DE to design wrapper scan chain. Through group’s mutation, crossover and selection operations, the design of test wrapper scan chain is achieved. Experimental verification is carried out according to the international standard benchmark ITC’02. The results show that the algorithm can obtain shorter longest wrapper scan chains, compared with other algorithms.

  14. Diagnosis of Food Allergy Based on Oral Food Challenge Test

    Directory of Open Access Journals (Sweden)

    Komei Ito

    2009-01-01

    Full Text Available Diagnosis of food allergy should be based on the observation of allergic symptoms after intake of the suspected food. The oral food challenge test (OFC is the most reliable clinical procedure for diagnosing food allergy. The OFC is also applied for the diagnosis of tolerance of food allergy. The Japanese Society of Pediatric Allergy and Clinical Immunology issued the 'Japanese Pediatric Guideline for Oral Food Challenge Test in Food Allergy 2009' in April 2009, to provide information on a safe and standardized method for administering the OFC. This review focuses on the clinical applications and procedure for the OFC, based on the Japanese OFC guideline.

  15. Social inequality and HIV-testing: Comparing home- and clinic-based testing in rural Malawi

    Directory of Open Access Journals (Sweden)

    Alexander A. Weinreb

    2009-10-01

    Full Text Available The plan to increase HIV testing is a cornerstone of the international health strategy against the HIV/AIDS epidemic, particularly in sub-Saharan Africa. This paper highlights a problematic aspect of that plan: the reliance on clinic- rather than home-based testing. First, drawing on DHS data from across Africa, we demonstrate the substantial differences in socio-demographic and economic profiles between those who report having ever had an HIV test, and those who report never having had one. Then, using data from a random household survey in rural Malawi, we show that substituting home-based for clinic-based testing may eliminate this source of inequality between those tested and those not tested. This result, which is stable across modeling frameworks, has important implications for accurately and equitably addressing the counseling and treatment programs that comprise the international health strategy against AIDS, and that promise to shape the future trajectory of the epidemic in Africa and beyond.

  16. Pharmacists performing quality spirometry testing: an evidence based review.

    Science.gov (United States)

    Cawley, Michael J; Warning, William J

    2015-10-01

    The scope of pharmacist services for patients with pulmonary disease has primarily focused on drug related outcomes; however pharmacists have the ability to broaden the scope of clinical services by performing diagnostic testing including quality spirometry testing. Studies have demonstrated that pharmacists can perform quality spirometry testing based upon international guidelines. The primary aim of this review was to assess the published evidence of pharmacists performing quality spirometry testing based upon American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines. In order to accomplish this, the description of evidence and type of outcome from these services were reviewed. A literature search was conducted using five databases [PubMed (1946-January 2015), International Pharmaceutical Abstracts (1970 to January 2015), Cumulative Index of Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews] with search terms including pharmacy, spirometry, pulmonary function, asthma or COPD was conducted. Searches were limited to publications in English and reported in humans. In addition, Uniform Resource Locators and Google Scholar searches were implemented to include any additional supplemental information. Eight studies (six prospective multi-center trials, two retrospective single center studies) were included. Pharmacists in all studies received specialized training in performing spirometry testing. Of the eight studies meeting inclusion and exclusion criteria, 8 (100%) demonstrated acceptable repeatability of spirometry testing based upon standards set by the ATS/ERS guidelines. Acceptable repeatability of seven studies ranged from 70 to 99% consistent with published data. Available evidence suggests that quality spirometry testing can be performed by pharmacists. More prospective studies are needed to add to the current evidence of quality spirometry testing performed by

  17. Vi har brug for dystopierne - men de kan ikke stå alene

    DEFF Research Database (Denmark)

    Baron, Christian

    2017-01-01

    Filmatiseringen af Margaret Atwoods »The Handmaid’s Tale« har aktualiseret dystopiens potentiale som samfundskritisk betydningsbærer. I sagens natur er dystopiens evne til at formulere alternativer til den udvikling, den advarer imod, imidlertid begrænsede. Vi har brug for litteratur, der tager...

  18. Harnessing the Power of Information Technology: Open Business Models in Higher Education

    Science.gov (United States)

    Sheets, Robert G.; Crawford, Stephen

    2012-01-01

    Higher education is under enormous pressure to improve outcomes and reduce costs. Information technology can help achieve these goals, but only if it is properly harnessed. This article argues that one key to harnessing information technology is business model innovation that results in more "open" and "unbundled" operations in learning and…

  19. Når sex er en ret, hvem har så pligt?

    DEFF Research Database (Denmark)

    Munk-Madsen, Eva

    2007-01-01

    Socialministeriet har fastslået i en vejledning, at samfundet har omsorgspligt for funktionshæmmedes borgeres  seksuelle udfoldelsesmulighder. Tre grupper er udpeget som dem der skal varetage denne omsorgspligt på samfundets vegne: ansatte hjælpepersoner, seksualvejledere og prostituerede. I modt...

  20. Jagttider: Hare, agerhøne og ederfugl har behov for mere beskyttelse

    DEFF Research Database (Denmark)

    Pedersen, Jens Christian

    2009-01-01

    De fleste bestande af de jagtbare arter har det rigtigt godt, men tre af de klassiske vildtarter, hare, agerhøne og ederfugl, er i problemer. Det fremgår af en 284-siders udredning som Danmarks Miljøundersøgelser ved Aarhus Universitet (DMU) har udarbejdet som fagligt grundlag for revisionen af...

  1. Harnessing type I and type III CRISPR-Cas systems for genome editing

    DEFF Research Database (Denmark)

    Li, Yingjun; Pan, Saifu; Zhang, Yan

    2016-01-01

    CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) systems are widespread in archaea and bacteria, and research on their molecular mechanisms has led to the development of genome-editing techniques based on a few Type II systems. However, there has not been any...... report on harnessing a Type I or Type III system for genome editing. Here, a method was developed to repurpose both CRISPR-Cas systems for genetic manipulation in Sulfolobus islandicus, a thermophilic archaeon. A novel type of genome-editing plasmid (pGE) was constructed, carrying an artificial mini-CRISPR...... and selectively retained as transformants. Using this strategy, different types of mutation were generated, including deletion, insertion and point mutations. We envision this method is readily applicable to different bacteria and archaea that carry an active CRISPR-Cas system of DNA interference provided...

  2. Antiviral Goes Viral: Harnessing CRISPR/Cas9 to Combat Viruses in Humans.

    Science.gov (United States)

    Soppe, Jasper Adriaan; Lebbink, Robert Jan

    2017-10-01

    The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) systems are RNA-guided sequence-specific prokaryotic antiviral immune systems. In prokaryotes, small RNA molecules guide Cas effector endonucleases to invading foreign genetic elements in a sequence-dependent manner, resulting in DNA cleavage by the endonuclease upon target binding. A rewired CRISPR/Cas9 system can be used for targeted and precise genome editing in eukaryotic cells. CRISPR/Cas has also been harnessed to target human pathogenic viruses as a potential new antiviral strategy. Here, we review recent CRISPR/Cas9-based approaches to combat specific human viruses in humans and discuss challenges that need to be overcome before CRISPR/Cas9 may be used in the clinic as an antiviral strategy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. An authoring tool for building both mobile adaptable tests and web-based adaptive or classic tests

    NARCIS (Netherlands)

    Romero, C.; Ventura, S.; Hervás, C.; De Bra, P.M.E.; Wade, V.; Ashman, H.; Smyth, B.

    2006-01-01

    This paper describes Test Editor, an authoring tool for building both mobile adaptable tests and web-based adaptive or classic tests. This tool facilitates the development and maintenance of different types of XML-based multiple- choice tests for using in web-based education systems and wireless

  4. High Frequency Vibration Based Fatigue Testing of Developmental Alloys

    Science.gov (United States)

    Holycross, Casey M.; Srinivasan, Raghavan; George, Tommy J.; Tamirisakandala, Seshacharyulu; Russ, Stephan M.

    Many fatigue test methods have been previously developed to rapidly evaluate fatigue behavior. This increased test speed can come at some expense, since these methods may require non-standard specimen geometry or increased facility and equipment capability. One such method, developed by George et al, involves a base-excited plate specimen driven into a high frequency bending resonant mode. This resonant mode is of sufficient frequency (typically 1200 to 1700 Hertz) to accumulate 107 cycles in a few hours. One of the main limitations of this test method is that fatigue cracking is almost certainly guaranteed to be surface initiated at regions of high stress. This brings into question the validity of the fatigue test results, as compared to more traditional uniaxial, smooth-bar testing, since high stresses are subjecting only a small volume to fatigue damage. This limitation also brings into question the suitability of this method to screen developmental alloys, should their initiation life be governed by subsurface flaws. However, if applicable, the rapid generation of fatigue data using this method would facilitate faster design iterations, identifying more quickly, material and manufacturing process deficiencies. The developmental alloy used in this study was a powder metallurgy boron-modified Ti-6Al-4V, a new alloy currently being considered for gas turbine engine fan blades. Plate specimens were subjected to fully reversed bending fatigue. Results are compared with existing data from commercially available Ti-6Al-4V using both vibration based and more traditional fatigue test methods.

  5. A sequential hypothesis test based on a generalized Azuma inequality

    NARCIS (Netherlands)

    Reijsbergen, D.P.; Scheinhardt, Willem R.W.; de Boer, Pieter-Tjerk

    We present a new power-one sequential hypothesis test based on a bound for the probability that a bounded zero-mean martingale ever crosses a curve of the form $a(n+k)^b$. The proof of the bound is of independent interest.

  6. Invariant-Based Automatic Testing of Modern Web Applications

    NARCIS (Netherlands)

    Mesbah, A.; Van Deursen, A.; Roest, D.

    2011-01-01

    AJAX-based Web 2.0 applications rely on stateful asynchronous client/server communication, and client-side run-time manipulation of the DOM tree. This not only makes them fundamentally different from traditional web applications, but also more error-prone and harder to test. We propose a method for

  7. Heart rate-based lactate minimum test: a reproducible method.

    NARCIS (Netherlands)

    Strupler, M.; Muller, G.; Perret, C.

    2009-01-01

    OBJECTIVE: To find the individual intensity for aerobic endurance training, the lactate minimum test (LMT) seems to be a promising method. LMTs described in the literature consist of speed or work rate-based protocols, but for training prescription in daily practice mostly heart rate is used. The

  8. Applications of decision theory to test-based decision making

    NARCIS (Netherlands)

    van der Linden, Willem J.

    1987-01-01

    The use of Bayesian decision theory to solve problems in test-based decision making is discussed. Four basic decision problems are distinguished: (1) selection; (2) mastery; (3) placement; and (4) classification, the situation where each treatment has its own criterion. Each type of decision can be

  9. Correlation Based Testing for Passive Sonar Picture Rationalization

    National Research Council Canada - National Science Library

    Mellema, Garfield R

    2007-01-01

    .... The sample correlation coefficient, is a statistical measure of relatedness. This paper describes the application of a test based on that measure to compare tracks produced by a probabilistic data association filter from a set of towed array sonar data. Keywords.

  10. A valuation-Based Test of Market Timing

    NARCIS (Netherlands)

    Koeter-Kant, J.; Elliott, W.B.; Warr, R.S.

    2007-01-01

    We implement an earnings-based fundamental valuation model to test the impact of market timing on the firm's method of funding the financing deficit. We argue that our valuation metric provides a superior measure of equity misvaluation because it avoids multiple interpretation problems faced by the

  11. Laboratory test of an APS-based sun sensor prototype

    Science.gov (United States)

    Rufino, Giancarlo; Perrotta, Alessandro; Grassi, Michele

    2017-11-01

    This paper deals with design and prototype development of an Active Pixel Sensor - based miniature sun sensor and a laboratory facility for its indoor test and calibration. The miniature sun sensor is described and the laboratory test facility is presented in detail. The major focus of the paper is on tests and calibration of the sensor. Two different calibration functions have been adopted. They are based, respectively, on a geometrical model, which has required least-squares optimisation of system physical parameters estimates, and on neural networks. Calibration results are presented for the above solutions, showing that accuracy in the order of 0.01° has been achieved. Neural calibration functions have attained better performance thanks to their intrinsic auto-adaptive structure.

  12. Computer Based Test Untuk Seleksi Masuk Politeknik Negeri Bengkalis

    Directory of Open Access Journals (Sweden)

    Agus Tedyyana

    2017-11-01

    Full Text Available AbstrakPenyeleksian calon mahasiswa baru dapat dilakukan dengan aplikasi Computer Based Test (CBT. Metode yang digunakan meliputi teknik pengumpulan data, analisis sistem, model perancangan, implementasi dan pengujian. Penelitian ini menghasilkan aplikasi CBT dimana soal yang dimunculkan dari bank soal melalui proses pengacakan dengan tidak akan memunculkan soal yang sama dengan menggunakan metoda Fisher-Yates Shuffle. Dalam proses pengamanan informasi soal saat terhubung ke jaringan maka diperlukan teknik untuk penyandian pesan agar soal tersebut sebeum dimunculkan melewati proses enkripsi dan deskripsi data terlebih dahulu maka digunakan algoritma kriptografi  RSA. Metode perancangan perangkat lunak menggunakan model waterfall, perancangan database menggunakan entity relationship diagram, perancangan antarmuka menggunakan hypertext markup language (HTML Cascading Style Sheet (CSS dan jQuery serta diimplementasikan berbasis web dengan menggunakan bahasa pemrograman PHP dan database MySQL, Arsitektur jaringan yang digunakan aplikasi Computer Based Test adalah model jaringan client-server dengan jaringan Local Area Network (LAN. Kata kunci: Computer Based Test, Fisher-Yates Shuffle, Criptography, Local Area Network AbstractSelection of new student candidates can be done with Computer Based Test (CBT application. The methods used include data collection techniques, system analysis, design model, implementation and testing. This study produces a CBT application where the questions raised from the question bank through randomization process will not bring up the same problem using the Fisher-Yates Shuffle method. In the process of securing information about the problem when connected to the network it is necessary techniques for encoding the message so that the problem before appear through the process of encryption and description of data first then used RSA cryptography algorithm. Software design method using waterfall model, database design

  13. Pile Design Based on Cone Penetration Test Results

    OpenAIRE

    Salgado, Rodrigo; Lee, Junhwan

    1999-01-01

    The bearing capacity of piles consists of both base resistance and side resistance. The side resistance of piles is in most cases fully mobilized well before the maximum base resistance is reached. As the side resistance is mobilized early in the loading process, the determination of pile base resistance is a key element of pile design. Static cone penetration is well related to the pile loading process, since it is performed quasi-statically and resembles a scaled-down pile load test. In ord...

  14. Communicative Language Testing: Implications for Computer Based Language Testing in French for Specific Purposes

    Science.gov (United States)

    García Laborda, Jesús; López Santiago, Mercedes; Otero de Juan, Nuria; Álvarez Álvarez, Alfredo

    2014-01-01

    Current evolutions of language testing have led to integrating computers in FSP assessments both in oral and written communicative tasks. This paper deals with two main issues: learners' expectations about the types of questions in FSP computer based assessments and the relation with their own experience. This paper describes the experience of 23…

  15. Failing Tests: Commentary on "Adapting Educational Measurement to the Demands of Test-Based Accountability"

    Science.gov (United States)

    Thissen, David

    2015-01-01

    In "Adapting Educational Measurement to the Demands of Test-Based Accountability" Koretz takes the time-honored engineering approach to educational measurement, identifying specific problems with current practice and proposing minimal modifications of the system to alleviate those problems. In response to that article, David Thissen…

  16. Computer-based tests: The impact of test design and problem of equivalency

    Czech Academy of Sciences Publication Activity Database

    Květon, Petr; Jelínek, Martin; Vobořil, Dalibor; Klimusová, H.

    -, č. 23 (2007), s. 32-51 ISSN 0747-5632 R&D Projects: GA ČR(CZ) GA406/99/1052; GA AV ČR(CZ) KSK9058117 Institutional research plan: CEZ:AV0Z7025918 Keywords : Computer-based assessment * speeded test * equivalency Subject RIV: AN - Psychology Impact factor: 1.344, year: 2007

  17. Examining the Use of Web-Based Tests for Testing Academic Vocabulary in EAP Instruction

    Science.gov (United States)

    Dashtestani, Reza

    2015-01-01

    Interest in Web-based and computer-assisted language testing is growing in the field of English for academic purposes (EAP). In this study, four groups of undergraduate EAP students (n = 120), each group consisted of 30 students, were randomly selected from four different disciplines, i.e. biology, political sciences, psychology, and law. The four…

  18. Students Perception on the Use of Computer Based Test

    Science.gov (United States)

    Nugroho, R. A.; Kusumawati, N. S.; Ambarwati, O. C.

    2018-02-01

    Teaching nowadays might use technology in order to disseminate science and knowledge. As part of teaching, the way evaluating study progress and result has also benefited from this IT rapid progress. The computer-based test (CBT) has been introduced to replace the more conventional Paper and Pencil Test (PPT). CBT are considered more advantageous than PPT. It is considered as more efficient, transparent, and has the ability of minimising fraud in cognitive evaluation. Current studies have indicated the debate of CBT vs PPT usage. Most of the current research compares the two methods without exploring the students’ perception about the test. This study will fill the gap in the literature by providing students’ perception on the two tests method. Survey approach is conducted to obtain the data. The sample is collected in two identical classes with similar subject in a public university in Indonesia. Mann-Whitney U test used to analyse the data. The result indicates that there is a significant difference between two groups of students regarding CBT usage. Student with different test method prefers to have test other than what they were having. Further discussion and research implication is discussed in the paper.

  19. A novel PMT test system based on waveform sampling

    Science.gov (United States)

    Yin, S.; Ma, L.; Ning, Z.; Qian, S.; Wang, Y.; Jiang, X.; Wang, Z.; Yu, B.; Gao, F.; Zhu, Y.; Wang, Z.

    2018-01-01

    Comparing with the traditional test system based on a QDC and TDC and scaler, a test system based on waveform sampling is constructed for signal sampling of the 8"R5912 and the 20"R12860 Hamamatsu PMT in different energy states from single to multiple photoelectrons. In order to achieve high throughput and to reduce the dead time in data processing, the data acquisition software based on LabVIEW is developed and runs with a parallel mechanism. The analysis algorithm is realized in LabVIEW and the spectra of charge, amplitude, signal width and rising time are analyzed offline. The results from Charge-to-Digital Converter, Time-to-Digital Converter and waveform sampling are discussed in detailed comparison.

  20. Bayesian models based on test statistics for multiple hypothesis testing problems.

    Science.gov (United States)

    Ji, Yuan; Lu, Yiling; Mills, Gordon B

    2008-04-01

    We propose a Bayesian method for the problem of multiple hypothesis testing that is routinely encountered in bioinformatics research, such as the differential gene expression analysis. Our algorithm is based on modeling the distributions of test statistics under both null and alternative hypotheses. We substantially reduce the complexity of the process of defining posterior model probabilities by modeling the test statistics directly instead of modeling the full data. Computationally, we apply a Bayesian FDR approach to control the number of rejections of null hypotheses. To check if our model assumptions for the test statistics are valid for various bioinformatics experiments, we also propose a simple graphical model-assessment tool. Using extensive simulations, we demonstrate the performance of our models and the utility of the model-assessment tool. In the end, we apply the proposed methodology to an siRNA screening and a gene expression experiment.

  1. Psychometric properties of a test in evidence based practice: the Spanish version of the Fresno test

    Directory of Open Access Journals (Sweden)

    Jiménez-Villa Josep

    2010-06-01

    Full Text Available Abstract Background Validated instruments are needed to evaluate the programmatic impact of Evidence Based Practice (EBP training and to document the competence of individual trainees. This study aimed to translate the Fresno test into Spanish and subsequently validate it, in order to ensure the equivalence of the Spanish version against the original English version. Methods Before and after study performed between October 2007 and June 2008. Three groups of participants: (a Mentors of family medicine residents (expert group (n = 56; (b Family medicine physicians (intermediate experience group (n = 17; (c Family medicine residents (novice group (n = 202; Medical residents attended an EBP course, and two sets of the test were administered before and after the course. The Fresno test is a performance based measure for use in medical education that assesses EBP skills. The outcome measures were: inter-rater and intra-rater reliability, internal consistency, item analyses, construct validity, feasibility of administration, and responsiveness. Results Inter-rater correlations were 0.95 and 0.85 in the pre-test and the post-test respectively. The overall intra-rater reliability was 0.71 and 0.81 in the pre-test and post-test questionnaire, respectively. Cronbach's alpha was 0.88 and 0.77, respectively. 152 residents (75.2% returned both sets of the questionnaire. The observed effect size for the residents was 1.77 (CI 95%: 1.57-1.95, the standardised response mean was 1.65 (CI 95%:1.47-1.82. Conclusions The Spanish version of the Fresno test is a useful tool in assessing the knowledge and skills of EBP in Spanish-speaking residents of Family Medicine.

  2. TR-EDB: Test Reactor Embrittlement Data Base, Version 1

    Energy Technology Data Exchange (ETDEWEB)

    Stallmann, F.W.; Wang, J.A.; Kam, F.B.K. [Oak Ridge National Lab., TN (United States)

    1994-01-01

    The Test Reactor Embrittlement Data Base (TR-EDB) is a collection of results from irradiation in materials test reactors. It complements the Power Reactor Embrittlement Data Base (PR-EDB), whose data are restricted to the results from the analysis of surveillance capsules in commercial power reactors. The rationale behind their restriction was the assumption that the results of test reactor experiments may not be applicable to power reactors and could, therefore, be challenged if such data were included. For this very reason the embrittlement predictions in the Reg. Guide 1.99, Rev. 2, were based exclusively on power reactor data. However, test reactor experiments are able to cover a much wider range of materials and irradiation conditions that are needed to explore more fully a variety of models for the prediction of irradiation embrittlement. These data are also needed for the study of effects of annealing for life extension of reactor pressure vessels that are difficult to obtain from surveillance capsule results.

  3. TR-EDB: Test Reactor Embrittlement Data Base, Version 1

    International Nuclear Information System (INIS)

    Stallmann, F.W.; Wang, J.A.; Kam, F.B.K.

    1994-01-01

    The Test Reactor Embrittlement Data Base (TR-EDB) is a collection of results from irradiation in materials test reactors. It complements the Power Reactor Embrittlement Data Base (PR-EDB), whose data are restricted to the results from the analysis of surveillance capsules in commercial power reactors. The rationale behind their restriction was the assumption that the results of test reactor experiments may not be applicable to power reactors and could, therefore, be challenged if such data were included. For this very reason the embrittlement predictions in the Reg. Guide 1.99, Rev. 2, were based exclusively on power reactor data. However, test reactor experiments are able to cover a much wider range of materials and irradiation conditions that are needed to explore more fully a variety of models for the prediction of irradiation embrittlement. These data are also needed for the study of effects of annealing for life extension of reactor pressure vessels that are difficult to obtain from surveillance capsule results

  4. Tests of gravity with future space-based experiments

    Science.gov (United States)

    Sakstein, Jeremy

    2018-03-01

    Future space-based tests of relativistic gravitation—laser ranging to Phobos, accelerometers in orbit, and optical networks surrounding Earth—will constrain the theory of gravity with unprecedented precision by testing the inverse-square law, the strong and weak equivalence principles, and the deflection and time delay of light by massive bodies. In this paper, we estimate the bounds that could be obtained on alternative gravity theories that use screening mechanisms to suppress deviations from general relativity in the Solar System: chameleon, symmetron, and Galileon models. We find that space-based tests of the parametrized post-Newtonian parameter γ will constrain chameleon and symmetron theories to new levels, and that tests of the inverse-square law using laser ranging to Phobos will provide the most stringent constraints on Galileon theories to date. We end by discussing the potential for constraining these theories using upcoming tests of the weak equivalence principle, and conclude that further theoretical modeling is required in order to fully utilize the data.

  5. Titan TTCN-3 Based Test Framework for Resource Constrained Systems

    Directory of Open Access Journals (Sweden)

    Yushev Artem

    2016-01-01

    Full Text Available Wireless communication systems more and more become part of our daily live. Especially with the Internet of Things (IoT the overall connectivity increases rapidly since everyday objects become part of the global network. For this purpose several new wireless protocols have arisen, whereas 6LoWPAN (IPv6 over Low power Wireless Personal Area Networks can be seen as one of the most important protocols within this sector. Originally designed on top of the IEEE802.15.4 standard it is a subject to various adaptions that will allow to use 6LoWPAN over different technologies; e.g. DECT Ultra Low Energy (ULE. Although this high connectivity offers a lot of new possibilities, there are several requirements and pitfalls coming along with such new systems. With an increasing number of connected devices the interoperability between different providers is one of the biggest challenges, which makes it necessary to verify the functionality and stability of the devices and the network. Therefore testing becomes one of the key components that decides on success or failure of such a system. Although there are several protocol implementations commonly available; e.g., for IoT based systems, there is still a lack of according tools and environments as well as for functional and conformance testing. This article describes the architecture and functioning of the proposed test framework based on Testing and Test Control Notation Version 3 (TTCN-3 for 6LoWPAN over ULE networks.

  6. A test beam upgrade based on the BEPC-LINAC

    International Nuclear Information System (INIS)

    Li Jiacai; Wu Yuanming; Cui Xiangzong; Zhang Liangsheng; Zhou Baoqing; Liu Zhengquan; Zhang Shaoping; Sun Changchun; Zhang Zhuxiang; Zhang Caidi; Zheng Linsheng; Liu Shixing; Shen Ji; Yin Zejie; Zhang Yongming; Chen Ziyu

    2004-01-01

    A total of three beam lines, E1, E2 and E3 have based on the LINAC of BEPC. The E1 beam is to be used for intense slow-positron facility. The E2 is a primary positron or electron beam with an energy of 1.3-1.5 GeV. The E3 is a secondary electron or pion test beam with a momentum can be adjustable continuously. The position accuracy of a detected particle is 0.2-0.4 mm with an event rate of 3 - 4 Hz. This beam has been successfully used for some detectors beam test. (author)

  7. Model-based automated testing of critical PLC programs.

    CERN Document Server

    Fernández Adiego, B; Tournier, J-C; González Suárez, V M; Bliudze, S

    2014-01-01

    Testing of critical PLC (Programmable Logic Controller) programs remains a challenging task for control system engineers as it can rarely be automated. This paper proposes a model based approach which uses the BIP (Behavior, Interactions and Priorities) framework to perform automated testing of PLC programs developed with the UNICOS (UNified Industrial COntrol System) framework. This paper defines the translation procedure and rules from UNICOS to BIP which can be fully automated in order to hide the complexity of the underlying model from the control engineers. The approach is illustrated and validated through the study of a water treatment process.

  8. Timer-based data acquisitioning of creep testing machines

    International Nuclear Information System (INIS)

    Rana, M.A.; Farooq, M.A.; Ali, L.

    1998-01-01

    Duration of a creep test may be short or long term extending over several years. Continuous operation of a computer for automatic data acquisition of creep testing machines is useless. Timer based data acquisitioning of the machines already interface with IBM-Pc/AT and compatibles has been streamlined for economical use of the computer. A locally designed and fabricated timer has been introduced in the system in this regard to meet the requirements of the system. The timer switches on the computer according to pre scheduled interval of time of capture creep data in Real time. The periodically captured data is logged on the hard disk for analysis and report generation. (author)

  9. Universal Verification Methodology Based Register Test Automation Flow.

    Science.gov (United States)

    Woo, Jae Hun; Cho, Yong Kwan; Park, Sun Kyu

    2016-05-01

    In today's SoC design, the number of registers has been increased along with complexity of hardware blocks. Register validation is a time-consuming and error-pron task. Therefore, we need an efficient way to perform verification with less effort in shorter time. In this work, we suggest register test automation flow based UVM (Universal Verification Methodology). UVM provides a standard methodology, called a register model, to facilitate stimulus generation and functional checking of registers. However, it is not easy for designers to create register models for their functional blocks or integrate models in test-bench environment because it requires knowledge of SystemVerilog and UVM libraries. For the creation of register models, many commercial tools support a register model generation from register specification described in IP-XACT, but it is time-consuming to describe register specification in IP-XACT format. For easy creation of register model, we propose spreadsheet-based register template which is translated to IP-XACT description, from which register models can be easily generated using commercial tools. On the other hand, we also automate all the steps involved integrating test-bench and generating test-cases, so that designers may use register model without detailed knowledge of UVM or SystemVerilog. This automation flow involves generating and connecting test-bench components (e.g., driver, checker, bus adaptor, etc.) and writing test sequence for each type of register test-case. With the proposed flow, designers can save considerable amount of time to verify functionality of registers.

  10. Salt Fog Testing Iron-Based Amorphous Alloys

    International Nuclear Information System (INIS)

    Rebak, Raul B.; Aprigliano, Louis F.; Day, S. Daniel; Farmer, Joseph C.

    2007-01-01

    Iron-based amorphous alloys are hard and highly corrosion resistant, which make them desirable for salt water and other applications. These alloys can be produced as powder and can be deposited as coatings on any surface that needs to be protected from the environment. It was of interest to examine the behavior of these amorphous alloys in the standard salt-fog testing ASTM B 117. Three different amorphous coating compositions were deposited on 316L SS coupons and exposed for many cycles of the salt fog test. Other common engineering alloys such as 1018 carbon steel, 316L SS and Hastelloy C-22 were also tested together with the amorphous coatings. Results show that amorphous coatings are resistant to rusting in salt fog. Partial devitrification may be responsible for isolated rust spots in one of the coatings. (authors)

  11. Tests of beam-based alignement at FACET

    CERN Document Server

    Latina, A; Schulte, D; Adli, E

    2014-01-01

    The performance of future linear colliders will depend critically on beam-based alignment (BBA) and feedback systems, which will play a crucial role in guaranteeing the low emittance transport throughout such machines. BBA algorithms designed to improve the beam transmission in a linac by simultaneously optimising the trajectory and minimising the residual dispersion, have thoughtfully been studied in theory over the last years, and successfully verified experimentally. One such technique is called Dispersion-Free Steering (DFS). A careful study of the DFS performance at the SLAC test facility FACET lead us to design a beam-based technique specifically targeted to reduce the impact of transverse short-range wakefields, rather than of the dispersion, being the wakefields the limiting factor to the FACET performance. This technique is called Wakefield-Free Steering (WFS). The results of the first tests of WFS at FACET are presented in this paper.

  12. Syndromic Panel-Based Testing in Clinical Microbiology.

    Science.gov (United States)

    Ramanan, Poornima; Bryson, Alexandra L; Binnicker, Matthew J; Pritt, Bobbi S; Patel, Robin

    2018-01-01

    The recent development of commercial panel-based molecular diagnostics for the rapid detection of pathogens in positive blood culture bottles, respiratory specimens, stool, and cerebrospinal fluid has resulted in a paradigm shift in clinical microbiology and clinical practice. This review focuses on U.S. Food and Drug Administration (FDA)-approved/cleared multiplex molecular panels with more than five targets designed to assist in the diagnosis of bloodstream, respiratory tract, gastrointestinal, or central nervous system infections. While these panel-based assays have the clear advantages of a rapid turnaround time and the detection of a large number of microorganisms and promise to improve health care, they present certain challenges, including cost and the definition of ideal test utilization strategies (i.e., optimal ordering) and test interpretation. Copyright © 2017 American Society for Microbiology.

  13. Testing R&D-Based Endogenous Growth Models

    DEFF Research Database (Denmark)

    Kruse-Andersen, Peter Kjær

    2017-01-01

    R&D-based growth models are tested using US data for the period 1953-2014. A general growth model is developed which nests the model varieties of interest. The model implies a cointegrating relationship between multifactor productivity, research intensity, and employment. This relationship...... is estimated using cointegrated VAR models. The results provide evidence against the widely used fully endogenous variety and in favor of the semi-endogenous variety. Forecasts based on the empirical estimates suggest that the slowdown in US productivity growth will continue. Particularly, the annual long...

  14. High volume tidal or current flow harnessing system

    Energy Technology Data Exchange (ETDEWEB)

    Gorlov, A.M.

    1984-08-07

    Apparatus permitting the utilization of large volumes of water in the harnessing and extracting of a portion of the power generated by the rise and fall of ocean tides, ocean currents, or flowing rivers includes the provision of a dam, and a specialized single cavity chamber of limited size as compared with the water head enclosed by the dam, and an extremely high volume gating system in which all or nearly all of the water between the high and low levels on either side of the dam is cyclically gated through the single chamber from one side of the dam to the other so as to alternately provide positive air pressure and a partial vacuum within the single chamber. In one embodiment, the specialized chamber has a barrier at the bottom which divides the bottom of the chamber in half, large ports at the bottom of the chamber to permit inflow and outflow of high volumes of water, and ganged structures having a higher total area than that of corresponding ports, in which the structures form sluice gates to selectively seal off and open different sets of ports. In another embodiment, a single chamber is used without a barrier. In this embodiment, vertical sluice gates are used which may be activated automatically by pressures acting on the sluice gates as a result of ingested and expelled water.

  15. Health as foreign policy: harnessing globalization for health.

    Science.gov (United States)

    Fidler, David P

    2006-12-01

    This paper explores the importance for health promotion of the rise of public health as a foreign policy issue. Although health promotion encompassed foreign policy as part of 'healthy public policy', mainstream foreign policy neglected public health and health promotion's role in it. Globalization forces health promotion, however, to address directly the relationship between public health and foreign policy. The need for 'health as foreign policy' is apparent from the prominence public health now has in all the basic governance functions served by foreign policy. The Secretary-General's United Nations (UN) reform proposals demonstrate the importance of foreign policy to health promotion as a core component of public health because the proposals embed public health in each element of the Secretary-General's vision for the UN in the 21st century. The emergence of health as foreign policy presents opportunities and risks for health promotion that can be managed by emphasizing that public health constitutes an integrated public good that benefits all governance tasks served by foreign policy. Any effort to harness globalization for public health will have to make health as foreign policy a centerpiece of its ambitions, and this task is now health promotion's burden and opportunity.

  16. Weakly supervised visual dictionary learning by harnessing image attributes.

    Science.gov (United States)

    Gao, Yue; Ji, Rongrong; Liu, Wei; Dai, Qionghai; Hua, Gang

    2014-12-01

    Bag-of-features (BoFs) representation has been extensively applied to deal with various computer vision applications. To extract discriminative and descriptive BoF, one important step is to learn a good dictionary to minimize the quantization loss between local features and codewords. While most existing visual dictionary learning approaches are engaged with unsupervised feature quantization, the latest trend has turned to supervised learning by harnessing the semantic labels of images or regions. However, such labels are typically too expensive to acquire, which restricts the scalability of supervised dictionary learning approaches. In this paper, we propose to leverage image attributes to weakly supervise the dictionary learning procedure without requiring any actual labels. As a key contribution, our approach establishes a generative hidden Markov random field (HMRF), which models the quantized codewords as the observed states and the image attributes as the hidden states, respectively. Dictionary learning is then performed by supervised grouping the observed states, where the supervised information is stemmed from the hidden states of the HMRF. In such a way, the proposed dictionary learning approach incorporates the image attributes to learn a semantic-preserving BoF representation without any genuine supervision. Experiments in large-scale image retrieval and classification tasks corroborate that our approach significantly outperforms the state-of-the-art unsupervised dictionary learning approaches.

  17. The globalization of health research: harnessing the scientific diaspora.

    Science.gov (United States)

    Anand, Nalini P; Hofman, Karen J; Glass, Roger I

    2009-04-01

    The scientific diaspora is a unique resource for U.S. universities. By drawing on the expertise, experience, and catalytic potential of diaspora scientists, universities can capitalize more fully on their diverse intellectual resources to make lasting contributions to global health. This article examines the unique contributions of the diaspora in international research collaborations, advantages of harnessing the diaspora and benefits to U.S. universities of fostering these collaborations, challenges faced by scientists who want to work with their home countries, examples of scientists engaging with their home countries, and specific strategies U.S. universities and donors can implement to catalyze these collaborations. The contributions of the diaspora to the United States are immense: International students enrolled in academic year 2007-2008 contributed an estimated $15 billion to the U.S. economy. As scientific research becomes increasingly global, the percentage of scientific publications with authors from foreign countries has grown from 8% in 1988 to 20% in 2005. Diaspora scientists can help build trusting relationships with scientists abroad, and international collaborations may improve the health of underserved populations at home. Although opportunities for diaspora networks are increasing, most home countries often lack enabling policies, infrastructure, and resources to effectively utilize their diaspora communities abroad. This article examines how some governments have successfully mobilized their scientific diaspora to become increasingly engaged in their national research agendas. Recommendations include specific strategies, including those that encourage U.S. universities to promote mini-sabbaticals and provide seed funding and flexible time frames.

  18. Harnessing high-dimensional hyperentanglement through a biphoton frequency comb

    Science.gov (United States)

    Xie, Zhenda; Zhong, Tian; Shrestha, Sajan; Xu, Xinan; Liang, Junlin; Gong, Yan-Xiao; Bienfang, Joshua C.; Restelli, Alessandro; Shapiro, Jeffrey H.; Wong, Franco N. C.; Wei Wong, Chee

    2015-08-01

    Quantum entanglement is a fundamental resource for secure information processing and communications, and hyperentanglement or high-dimensional entanglement has been separately proposed for its high data capacity and error resilience. The continuous-variable nature of the energy-time entanglement makes it an ideal candidate for efficient high-dimensional coding with minimal limitations. Here, we demonstrate the first simultaneous high-dimensional hyperentanglement using a biphoton frequency comb to harness the full potential in both the energy and time domain. Long-postulated Hong-Ou-Mandel quantum revival is exhibited, with up to 19 time-bins and 96.5% visibilities. We further witness the high-dimensional energy-time entanglement through Franson revivals, observed periodically at integer time-bins, with 97.8% visibility. This qudit state is observed to simultaneously violate the generalized Bell inequality by up to 10.95 standard deviations while observing recurrent Clauser-Horne-Shimony-Holt S-parameters up to 2.76. Our biphoton frequency comb provides a platform for photon-efficient quantum communications towards the ultimate channel capacity through energy-time-polarization high-dimensional encoding.

  19. Space Launch System Base Heating Test: Environments and Base Flow Physics

    Science.gov (United States)

    Mehta, Manish; Knox, Kyle S.; Seaford, C. Mark; Dufrene, Aaron T.

    2016-01-01

    The NASA Space Launch System (SLS) vehicle is composed of four RS-25 liquid oxygen- hydrogen rocket engines in the core-stage and two 5-segment solid rocket boosters and as a result six hot supersonic plumes interact within the aft section of the vehicle during ight. Due to the complex nature of rocket plume-induced ows within the launch vehicle base during ascent and a new vehicle con guration, sub-scale wind tunnel testing is required to reduce SLS base convective environment uncertainty and design risk levels. This hot- re test program was conducted at the CUBRC Large Energy National Shock (LENS) II short-duration test facility to simulate ight from altitudes of 50 kft to 210 kft. The test program is a challenging and innovative e ort that has not been attempted in 40+ years for a NASA vehicle. This presentation discusses the various trends of base convective heat ux and pressure as a function of altitude at various locations within the core-stage and booster base regions of the two-percent SLS wind tunnel model. In-depth understanding of the base ow physics is presented using the test data, infrared high-speed imaging and theory. The normalized test design environments are compared to various NASA semi- empirical numerical models to determine exceedance and conservatism of the ight scaled test-derived base design environments. Brief discussion of thermal impact to the launch vehicle base components is also presented.

  20. SABATPG-A Structural Analysis Based Automatic Test Generation System

    Institute of Scientific and Technical Information of China (English)

    李忠诚; 潘榆奇; 闵应骅

    1994-01-01

    A TPG system, SABATPG, is given based on a generic structural model of large circuits. Three techniques of partial implication, aftereffect of identified undetectable faults and shared sensitization with new concepts of localization and aftereffect are employed in the system to improve FAN algorithm. Experiments for the 10 ISCAS benchmark circuits show that the computing time of SABATPG for test generation is 19.42% less than that of FAN algorithm.

  1. Investigation of Concrete Electrical Resistivity As a Performance Based Test

    OpenAIRE

    Malakooti, Amir

    2017-01-01

    The purpose of this research project was to identify the extent that concrete resistivity measurements (bulk and/or surface) can be used as a performance based lab test to improve the quality of concrete in Utah bridge decks. By allowing UDOT to specify a required resistivity, concrete bridge deck quality will increase and future maintenance costs will decrease. This research consisted of two phases: the field phase and the lab phase. In the field phase, concrete samples were gathered from...

  2. Self-testing protocols based on the chained Bell inequalities

    International Nuclear Information System (INIS)

    Šupić, I; Augusiak, R; Salavrakos, A; Acín, A

    2016-01-01

    Self-testing is a device-independent technique based on non-local correlations whose aim is to certify the effective uniqueness of the quantum state and measurements needed to produce these correlations. It is known that the maximal violation of some Bell inequalities suffices for this purpose. However, most of the existing self-testing protocols for two devices exploit the well-known Clauser–Horne–Shimony–Holt Bell inequality or modifications of it, and always with two measurements per party. Here, we generalize the previous results by demonstrating that one can construct self-testing protocols based on the chained Bell inequalities, defined for two devices implementing an arbitrary number of two-output measurements. On the one hand, this proves that the quantum state and measurements leading to the maximal violation of the chained Bell inequality are unique. On the other hand, in the limit of a large number of measurements, our approach allows one to self-test the entire plane of measurements spanned by the Pauli matrices X and Z. Our results also imply that the chained Bell inequalities can be used to certify two bits of perfect randomness. (paper)

  3. The Test Reactor Embrittlement Data Base (TR-EDB)

    International Nuclear Information System (INIS)

    Stallmann, F.W.; Kam, F.B.K.; Wang, J.A.

    1993-01-01

    The Test Reactor Embrittlement Data Base (TR-EDB) is part of an ongoing program to collect test data from materials irradiations to aid in the research and evaluation of embrittlement prediction models that are used to assure the safety of pressure vessels in power reactors. This program is being funded by the US Nuclear Regulatory Commission (NRC) and has resulted in the publication of the Power Reactor Embrittlement Data Base (PR-EDB) whose second version is currently being released. The TR-EDB is a compatible collection of data from experiments in materials test reactors. These data contain information that is not obtainable from surveillance results, especially, about the effects of annealing after irradiation. Other information that is only available from test reactors is the influence of fluence rates and irradiation temperatures on radiation embrittlement. The first version of the TR-EDB will be released in fall of 1993 and contains published results from laboratories in many countries. Data collection will continue and further updates will be published

  4. Strengthening Theoretical Testing in Criminology Using Agent-based Modeling.

    Science.gov (United States)

    Johnson, Shane D; Groff, Elizabeth R

    2014-07-01

    The Journal of Research in Crime and Delinquency ( JRCD ) has published important contributions to both criminological theory and associated empirical tests. In this article, we consider some of the challenges associated with traditional approaches to social science research, and discuss a complementary approach that is gaining popularity-agent-based computational modeling-that may offer new opportunities to strengthen theories of crime and develop insights into phenomena of interest. Two literature reviews are completed. The aim of the first is to identify those articles published in JRCD that have been the most influential and to classify the theoretical perspectives taken. The second is intended to identify those studies that have used an agent-based model (ABM) to examine criminological theories and to identify which theories have been explored. Ecological theories of crime pattern formation have received the most attention from researchers using ABMs, but many other criminological theories are amenable to testing using such methods. Traditional methods of theory development and testing suffer from a number of potential issues that a more systematic use of ABMs-not without its own issues-may help to overcome. ABMs should become another method in the criminologists toolbox to aid theory testing and falsification.

  5. Properties of permutation-based gene tests and controlling type 1 error using a summary statistic based gene test.

    Science.gov (United States)

    Swanson, David M; Blacker, Deborah; Alchawa, Taofik; Ludwig, Kerstin U; Mangold, Elisabeth; Lange, Christoph

    2013-11-07

    The advent of genome-wide association studies has led to many novel disease-SNP associations, opening the door to focused study on their biological underpinnings. Because of the importance of analyzing these associations, numerous statistical methods have been devoted to them. However, fewer methods have attempted to associate entire genes or genomic regions with outcomes, which is potentially more useful knowledge from a biological perspective and those methods currently implemented are often permutation-based. One property of some permutation-based tests is that their power varies as a function of whether significant markers are in regions of linkage disequilibrium (LD) or not, which we show from a theoretical perspective. We therefore develop two methods for quantifying the degree of association between a genomic region and outcome, both of whose power does not vary as a function of LD structure. One method uses dimension reduction to "filter" redundant information when significant LD exists in the region, while the other, called the summary-statistic test, controls for LD by scaling marker Z-statistics using knowledge of the correlation matrix of markers. An advantage of this latter test is that it does not require the original data, but only their Z-statistics from univariate regressions and an estimate of the correlation structure of markers, and we show how to modify the test to protect the type 1 error rate when the correlation structure of markers is misspecified. We apply these methods to sequence data of oral cleft and compare our results to previously proposed gene tests, in particular permutation-based ones. We evaluate the versatility of the modification of the summary-statistic test since the specification of correlation structure between markers can be inaccurate. We find a significant association in the sequence data between the 8q24 region and oral cleft using our dimension reduction approach and a borderline significant association using the

  6. Testing for Turkeys Faith-Based Community HIV Testing Initiative: An Update.

    Science.gov (United States)

    DeGrezia, Mary; Baker, Dorcas; McDowell, Ingrid

    2018-06-04

    Testing for Turkeys (TFT) HIV/hepatitis C virus (HCV) and sexually transmitted infection (STI) testing initiative is a joint effort between Older Women Embracing Life (OWEL), Inc., a nonprofit faith-based community HIV support and advocacy organization; the Johns Hopkins University Regional Partner MidAtlantic AIDS Education and Training Center (MAAETC); and the University of Maryland, Baltimore JACQUES Initiative (JI), and is now in its 11th year of providing HIV outreach, testing, and linkage to care. Since 2008, the annual TFT daylong community HIV testing and linkage to care initiative has been held 2 weeks before Thanksgiving at a faith-based center in Baltimore, Maryland, in a zip code where one in 26 adults and adolescents ages 13 years and older are living with HIV (Maryland Department of Health, Center for HIV Surveillance, Epidemiology, and Evaluation, 2017). TFT includes a health fair with vendors that supply an abundance of education information (handouts, videos, one-on-one counseling) and safer sex necessities, including male and female condoms, dental dams, and lube. Nutritious boxed lunches and beverages are provided to all attendees and volunteers. Everyone tested for HIV who stays to obtain their results is given a free frozen turkey as they exit. The Baltimore City Health Department is on hand with a confidential no-test list (persons in the state already known to have HIV) to diminish retesting of individuals previously diagnosed with HIV. However, linkage to care is available to everyone: newly diagnosed individuals and those previously diagnosed and currently out of care. Copyright © 2018 Association of Nurses in AIDS Care. Published by Elsevier Inc. All rights reserved.

  7. Standard Test Method for Preparing Aircraft Cleaning Compounds, Liquid Type, Water Base, for Storage Stability Testing

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2002-01-01

    1.1 This test method covers the determination of the stability in storage, of liquid, water-base chemical cleaning compounds, used to clean the exterior surfaces of aircraft. 1.2 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

  8. Inquiry-Based Instruction and High Stakes Testing

    Science.gov (United States)

    Cothern, Rebecca L.

    Science education is a key to economic success for a country in terms of promoting advances in national industry and technology and maximizing competitive advantage in a global marketplace. The December 2010 Program for International Student Assessment (PISA) ranked the United States 23rd of 65 countries in science. That dismal standing in science proficiency impedes the ability of American school graduates to compete in the global market place. Furthermore, the implementation of high stakes testing in science mandated by the 2007 No Child Left Behind (NCLB) Act has created an additional need for educators to find effective science pedagogy. Research has shown that inquiry-based science instruction is one of the predominant science instructional methods. Inquiry-based instruction is a multifaceted teaching method with its theoretical foundation in constructivism. A correlational survey research design was used to determine the relationship between levels of inquiry-based science instruction and student performance on a standardized state science test. A self-report survey, using a Likert-type scale, was completed by 26 fifth grade teachers. Participants' responses were analyzed and grouped as high, medium, or low level inquiry instruction. The unit of analysis for the achievement variable was the student scale score average from the state science test. Spearman's Rho correlation data showed a positive relationship between the level of inquiry-based instruction and student achievement on the state assessment. The findings can assist teachers and administrators by providing additional research on the benefits of the inquiry-based instructional method. Implications for positive social change include increases in student proficiency and decision-making skills related to science policy issues which can help make them more competitive in the global marketplace.

  9. Adult age differences in perceptually based, but not conceptually based implicit tests of memory.

    Science.gov (United States)

    Small, B J; Hultsch, D F; Masson, M E

    1995-05-01

    Implicit tests of memory assess the influence of recent experience without requiring awareness of remembering. Evidence concerning age differences on implicit tests of memory suggests small age differences in favor of younger adults. However, the majority of research examining this issue has relied upon perceptually based implicit tests. Recently, a second type of implicit test, one that relies upon conceptually based processes, has been identified. The pattern of age differences on this second type of implicit test is less clear. In the present study, we examined the pattern of age differences on one conceptually based (fact completion) and one perceptually based (stem completion) implicit test of memory, as well as two explicit tests of memory (fact and word recall). Tasks were administered to 403 adults from three age groups (19-34 years, 58-73 years, 74-89 years). Significant age differences in favor of the young were found on stem completion but not fact completion. Age differences were present for both word and fast recall. Correlational analyses examining the relationship of memory performance to other cognitive variables indicated that the implicit tests were supported by different components than the explicit tests, as well as being different from each other.

  10. En analyse av prestasjonsbasert belønning og hvilken effekt den har i Flytoget

    OpenAIRE

    Stousland, Kine

    2013-01-01

    Prestasjonsbasert belønning har vært i vinden de siste årene, og stadig flere bedrifter har tatt i bruk denne lønnsmetoden for å motivere ansatte til høyere effektivitet og bedre prestasjoner. Flytoget har kastet seg på denne bølgen og laget en medarbeiderbonus med samme kriterier for hele bedriften. Bonusen blir utbetalt en gang per år, og for å få full bonus må Flytoget oppnå 97% kundetilfredshet og fastsatt budsjett. Flytoget er en relativt liten bedrift med 334 ansatte. Hovedoppgaven t...

  11. Automation of Flight Software Regression Testing

    Science.gov (United States)

    Tashakkor, Scott B.

    2016-01-01

    NASA is developing the Space Launch System (SLS) to be a heavy lift launch vehicle supporting human and scientific exploration beyond earth orbit. SLS will have a common core stage, an upper stage, and different permutations of boosters and fairings to perform various crewed or cargo missions. Marshall Space Flight Center (MSFC) is writing the Flight Software (FSW) that will operate the SLS launch vehicle. The FSW is developed in an incremental manner based on "Agile" software techniques. As the FSW is incrementally developed, testing the functionality of the code needs to be performed continually to ensure that the integrity of the software is maintained. Manually testing the functionality on an ever-growing set of requirements and features is not an efficient solution and therefore needs to be done automatically to ensure testing is comprehensive. To support test automation, a framework for a regression test harness has been developed and used on SLS FSW. The test harness provides a modular design approach that can compile or read in the required information specified by the developer of the test. The modularity provides independence between groups of tests and the ability to add and remove tests without disturbing others. This provides the SLS FSW team a time saving feature that is essential to meeting SLS Program technical and programmatic requirements. During development of SLS FSW, this technique has proved to be a useful tool to ensure all requirements have been tested, and that desired functionality is maintained, as changes occur. It also provides a mechanism for developers to check functionality of the code that they have developed. With this system, automation of regression testing is accomplished through a scheduling tool and/or commit hooks. Key advantages of this test harness capability includes execution support for multiple independent test cases, the ability for developers to specify precisely what they are testing and how, the ability to add

  12. Risk based test interval and maintenance optimisation - Application and uses

    International Nuclear Information System (INIS)

    Sparre, E.

    1999-10-01

    The project is part of an IAEA co-ordinated Research Project (CRP) on 'Development of Methodologies for Optimisation of Surveillance Testing and Maintenance of Safety Related Equipment at NPPs'. The purpose of the project is to investigate the sensitivity of the results obtained when performing risk based optimisation of the technical specifications. Previous projects have shown that complete LPSA models can be created and that these models allow optimisation of technical specifications. However, these optimisations did not include any in depth check of the result sensitivity with regards to methods, model completeness etc. Four different test intervals have been investigated in this study. Aside from an original, nominal, optimisation a set of sensitivity analyses has been performed and the results from these analyses have been compared to the original optimisation. The analyses indicate that the result of an optimisation is rather stable. However, it is not possible to draw any certain conclusions without performing a number of sensitivity analyses. Significant differences in the optimisation result were discovered when analysing an alternative configuration. Also deterministic uncertainties seem to affect the result of an optimisation largely. The sensitivity of failure data uncertainties is important to investigate in detail since the methodology is based on the assumption that the unavailability of a component is dependent on the length of the test interval

  13. A computer vision based candidate for functional balance test.

    Science.gov (United States)

    Nalci, Alican; Khodamoradi, Alireza; Balkan, Ozgur; Nahab, Fatta; Garudadri, Harinath

    2015-08-01

    Balance in humans is a motor skill based on complex multimodal sensing, processing and control. Ability to maintain balance in activities of daily living (ADL) is compromised due to aging, diseases, injuries and environmental factors. Center for Disease Control and Prevention (CDC) estimate of the costs of falls among older adults was $34 billion in 2013 and is expected to reach $54.9 billion in 2020. In this paper, we present a brief review of balance impairments followed by subjective and objective tools currently used in clinical settings for human balance assessment. We propose a novel computer vision (CV) based approach as a candidate for functional balance test. The test will take less than a minute to administer and expected to be objective, repeatable and highly discriminative in quantifying ability to maintain posture and balance. We present an informal study with preliminary data from 10 healthy volunteers, and compare performance with a balance assessment system called BTrackS Balance Assessment Board. Our results show high degree of correlation with BTrackS. The proposed system promises to be a good candidate for objective functional balance tests and warrants further investigations to assess validity in clinical settings, including acute care, long term care and assisted living care facilities. Our long term goals include non-intrusive approaches to assess balance competence during ADL in independent living environments.

  14. Vision-based Ground Test for Active Debris Removal

    Directory of Open Access Journals (Sweden)

    Seong-Min Lim

    2013-12-01

    Full Text Available Due to the continuous space development by mankind, the number of space objects including space debris in orbits around the Earth has increased, and accordingly, difficulties of space development and activities are expected in the near future. In this study, among the stages for space debris removal, the implementation of a vision-based approach technique for approaching space debris from a far-range rendezvous state to a proximity state, and the ground test performance results were described. For the vision-based object tracking, the CAM-shift algorithm with high speed and strong performance, and the Kalman filter were combined and utilized. For measuring the distance to a tracking object, a stereo camera was used. For the construction of a low-cost space environment simulation test bed, a sun simulator was used, and in the case of the platform for approaching, a two-dimensional mobile robot was used. The tracking status was examined while changing the position of the sun simulator, and the results indicated that the CAM-shift showed a tracking rate of about 87% and the relative distance could be measured down to 0.9 m. In addition, considerations for future space environment simulation tests were proposed.

  15. Prevailence of Patch Test Positivity with Some Bases

    Directory of Open Access Journals (Sweden)

    J S Pasricha

    1987-01-01

    Full Text Available To evaluate the suitability of some chemicals to act as bases for antigens for patch tests, patch tests were performed with these agents in patients having contact dermatitis. Propylene glycol′used as such produced positive reactions in 25 (50% patients of which 12 were 2 + or more, polyethylene glycol 200 produced positive reactions in 9 (18% cases of which 4 cases were 2 + or more, a mixture of liquid paraffin and hard paraffin gave rise to positive reactions in 10 (10% cases 3 of these being 2 +, a mixture of liquid paraffin and bees wax was positive in 14 (14,Yo cases 3 of these being 2 +, yellow petrolatum was positive in 4 (8% cases, one of which was 2 +, white petrolatum was positive in S (6% cases all of these being + reactions only, and glycerol gave rise to a I + reaction in only one (2% caw. In tropical countries, water should be as base for as many antigens as possible for others, a control test with the b must be included.

  16. A Universal Motor Performance Test System Based on Virtual Instrument

    Directory of Open Access Journals (Sweden)

    Wei Li

    2014-09-01

    Full Text Available With the development of technology universal motors play a more and more important role in daily life and production, they have been used in increasingly wide field and the requirements increase gradually. How to control the speed and monitor the real-time temperature of motors are key issues. The cost of motor testing system based on traditional technology platform is very high in many reasons. In the paper a universal motor performance test system which based on virtual instrument is provided. The system achieves the precise control of the current motor speed and completes the measurement of real-time temperature of motor bearing support in order to realize the testing of general-purpose motor property. Experimental result shows that the system can work stability in controlling the speed and monitoring the real-time temperature. It has advantages that traditional using of SCM cannot match in speed, stability, cost and accuracy aspects. Besides it is easy to expand and reconfigure.

  17. Test-Driven, Model-Based Systems Engineering

    DEFF Research Database (Denmark)

    Munck, Allan

    Hearing systems have evolved over many years from simple mechanical devices (horns) to electronic units consisting of microphones, amplifiers, analog filters, loudspeakers, batteries, etc. Digital signal processors replaced analog filters to provide better performance end new features. Central....... This thesis concerns methods for identifying, selecting and implementing tools for various aspects of model-based systems engineering. A comprehensive method was proposed that include several novel steps such as techniques for analyzing the gap between requirements and tool capabilities. The method...... was verified with good results in two case studies for selection of a traceability tool (single-tool scenario) and a set of modeling tools (multi-tool scenarios). Models must be subjected to testing to allow engineers to predict functionality and performance of systems. Test-first strategies are known...

  18. Improvement of testing and maintenance based on fault tree analysis

    International Nuclear Information System (INIS)

    Cepin, M.

    2000-01-01

    Testing and maintenance of safety equipment is an important issue, which significantly contributes to safe and efficient operation of a nuclear power plant. In this paper a method, which extends the classical fault tree with time, is presented. Its mathematical model is represented by a set of equations, which include time requirements defined in the house event matrix. House events matrix is a representation of house events switched on and off through the discrete points of time. It includes house events, which timely switch on and off parts of the fault tree in accordance with the status of the plant configuration. Time dependent top event probability is calculated by the fault tree evaluations. Arrangement of components outages is determined on base of minimization of mean system unavailability. The results show that application of the method may improve the time placement of testing and maintenance activities of safety equipment. (author)

  19. Test of a PCIe based readout option for PANDA

    Energy Technology Data Exchange (ETDEWEB)

    Reiter, Simon; Lange, Soeren; Kuehn, Wolfgang [Justus-Liebig-Universitaet Giessen (Germany); Engel, Heiko [Goethe-Universitaet Frankfurt (Germany); Collaboration: PANDA-Collaboration

    2016-07-01

    The future PANDA detector will achieve an event rate at about 20 MHz resulting in a high data load of up to 200 GB/s. The data acquisition system will be based on a triggerless readout concept, leading to the requirement of large data bandwidths. The data reduction will be guaranteed on the first level by an array of FPGAs running a full on-line reconstruction followed by the second level of a CPU/GPU cluster to achieve a reduction factor more than 1000. The C-RORC (Common Readout Receiver Card), originally developed for ALICE, provides on the one hand 12 optical links with 6.25 Gbps each, and on the other hand a PCIe interface with up to 40 Gbps. The receiver card has been installed and tested, and the firmware has been adjusted for the Panda data format. Test results are presented.

  20. Development of training simulator based on critical assemblies test bench

    International Nuclear Information System (INIS)

    Narozhnyi, A.T.; Vorontsov, S.V.; Golubeva, O.A.; Dyudyaev, A.M.; Il'in, V.I.; Kuvshinov, M.I.; Panin, A.V.; Peshekhonov, D.P.

    2007-01-01

    When preparing critical mass experiment, multiplying system (MS) parts are assembled manually. This work is connected with maximum professional risk to personnel. Personnel training and keeping the skill of working experts is the important factor of nuclear safety maintenance. For this purpose authors develop a training simulator based on functioning critical assemblies test bench (CATB), allowing simulation of the MS assemblage using training mockups made of inert materials. The control program traces the current status of MS under simulation. A change in the assembly neutron physical parameters is mapped in readings of the regular devices. The simulator information support is provided by the computer database on physical characteristics of typical MS components The work in the training mode ensures complete simulation of real MS assemblage on the critical test bench. It makes it possible to elaborate the procedures related to CATB operation in a standard mode safely and effectively and simulate possible abnormal situations. (author)

  1. LncRNAWiki: harnessing community knowledge in collaborative curation of human long non-coding RNAs

    KAUST Repository

    Ma, L.

    2014-11-15

    Long non-coding RNAs (lncRNAs) perform a diversity of functions in numerous important biological processes and are implicated in many human diseases. In this report we present lncRNAWiki (http://lncrna.big.ac.cn), a wiki-based platform that is open-content and publicly editable and aimed at community-based curation and collection of information on human lncRNAs. Current related databases are dependent primarily on curation by experts, making it laborious to annotate the exponentially accumulated information on lncRNAs, which inevitably requires collective efforts in community-based curation of lncRNAs. Unlike existing databases, lncRNAWiki features comprehensive integration of information on human lncRNAs obtained from multiple different resources and allows not only existing lncRNAs to be edited, updated and curated by different users but also the addition of newly identified lncRNAs by any user. It harnesses community collective knowledge in collecting, editing and annotating human lncRNAs and rewards community-curated efforts by providing explicit authorship based on quantified contributions. LncRNAWiki relies on the underling knowledge of scientific community for collective and collaborative curation of human lncRNAs and thus has the potential to serve as an up-to-date and comprehensive knowledgebase for human lncRNAs.

  2. Bond strength test of acrylic artificial teeth with prosthetic base

    Directory of Open Access Journals (Sweden)

    Erna Kurnikasari

    2008-07-01

    Full Text Available Denture consists of acrylic artificial teeth and acrylic prothesis base bond chemically with a bond strength of 315 kgF/cm2. Most of the commercial acrylic artificial teeth do not specify their specifications and all of those acrylic artificial teeth do not include mechanical data (bond strength. The aim of this study is to discover which acrylic artificial teeth meet ADA specification no. 15. This study is a descriptive analytic study performed to 5 acrylic artificial teeth posterior brands commonly used by dentists and technicians. From each brand, 3 sample teeth were taken. The acrylic artificial teeth were prepared into a rectangular shape and were attached between acrylic prothesis base simulation and jigs. The sample was given tensile load using a Universal Testing Machine. The amount of force that causes the teeth to be fractured was recorded and the bond strength was calculated. The results of the study show that the average value for the five acrylic artificial teeth for the five brands were as followed: Brand A, 125.993 kgF/cm2; B, 188.457 kgF/cm2; C, 175.880 kgF/cm2; D, 153.373 kgF/cm2; E, 82.839 kgF/cm2. The data can be tested statistically by using One Way ANOVA test and Dunnett test (alpha = 0.05. From the study, it is concluded that the five acrylic artificial teeth have a bond strength below the ADA specification no. 15.

  3. Development Testing of 1-Newton ADN-Based Rocket Engines

    Science.gov (United States)

    Anflo, K.; Gronland, T.-A.; Bergman, G.; Nedar, R.; Thormählen, P.

    2004-10-01

    With the objective to reduce operational hazards and improve specific and density impulse as compared with hydrazine, the Research and Development (R&D) of a new monopropellant for space applications based on AmmoniumDiNitramide (ADN), was first proposed in 1997. This pioneering work has been described in previous papers1,2,3,4 . From the discussion above, it is clear that cost savings as well as risk reduction are the main drivers to develop a new generation of reduced hazard propellants. However, this alone is not enough to convince a spacecraft builder to choose a new technology. Cost, risk and schedule reduction are good incentives, but a spacecraft supplier will ask for evidence that this new propulsion system meets a number of requirements within the following areas: This paper describes the ongoing effort to develop a storable liquid monopropellant blend, based on AND, and its specific rocket engines. After building and testing more than 20 experimental rocket engines, the first Engineering Model (EM-1) has now accumulated more than 1 hour of firing-time. The results from test firings have validated the design. Specific impulse, combustion stability, blow-down capability and short pulse capability are amongst the requirements that have been demonstrated. The LMP-103x propellant candidate has been stored for more than 1 year and initial material compatibility screening and testing has started. 1. Performance &life 2. Impact on spacecraft design &operation 3. Flight heritage Hereafter, the essential requirements for some of these areas are outlined. These issues are discussed in detail in a previous paper1 . The use of "Commercial Of The Shelf" (COTS) propulsion system components as much as possible is essential to minimize the overall cost, risk and schedule. This leads to the conclusion that the Technology Readiness Level (TRL) 5 has been reached for the thruster and propellant. Furthermore, that the concept of ADN-based propulsion is feasible.

  4. Powder-based 3D printing application for geomechanical testing

    Science.gov (United States)

    Williams, M.; Yoon, H.; Choens, R. C., II; Martinez, M. J.; Dewers, T. A.; Lee, M.

    2017-12-01

    3D printing of fractured and porous analog geomaterials has the potential to enhance hydrogeological and mechanical interpretations by generating engineered samples in testable configurations with reproducible microstructures and tunable surface and mechanical properties. For geoscience applications, 3D printing technology can be co-opted to print reproducible structures derived from CT-imaging of actual rocks and theoretical algorithms. In particular, the use of 3D printed samples allows us to overcome sample-to-sample heterogeneity that plague rock physics testing and to test material response independent from material variability. In this work, gypsum powder-based 3D printing was used to print cylindrical core samples and block samples with a pre-existing flaw geometry. All samples are printed in three different directions to evaluate the impact of printing direction on mechanical properties. For the cylindrical samples, unconfined compression testing has been performed. For compressive strength, the samples printed perpendicular to the loading direction show stronger than those printed parallel to the loading and at 45 degree. Micro-CT images of the printed samples reveal the uneven spreading of binder, resulting in soft inner core surrounded by stronger outer shell. In particular, the layered feature with binder causes the strong anisotropic properties. This was also confirmed by the wave velocity. For the small block samples ( 6.1cm wide, 10cm high, and 1.25cm thick) with an inclined flaw, uniaxial tests coupled with an array of acoustic emission sensors and digital image correlation revealed that cracks were developed at/near the tip of flaw as expected. Although acoustic events were detected, localization was not detectable mainly due to strong attenuation. Advantage and disadvantage of power-based 3D printing for mechanical testing will be discussed and a few attempts will be presented to improve the applicability of powder-based printing technique. Sandia

  5. Harnessing the Ocean's Power : Energy from Waves and Currents (Part I)

    OpenAIRE

    Yukihisa, Washio; Japan Marine Science and Technology Center

    1985-01-01

    The oceans are a potential source of renewable and pollution-free energy of particular importance to Japan. In this Issue we look at current development work to harness wave energy for power generation.

  6. Harnessing Mobile Phones for Prevention of Mother-to-Child HIV ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Harnessing Mobile Phones for Prevention of Mother-to-Child HIV Transmission. Mobile phone technology, driven by local market forces rather than foreign assistance, ... IDRC invites applications for the IDRC Research Awards 2019. IDRC is ...

  7. Harnessing light: optical science and engineering for the 21st century

    National Research Council Canada - National Science Library

    Committee on Optical Science and Engineering, National Research Council

    .... Harnessing Light surveys this multitude of applications, as well as the status of the optics industry and of research and education in optics, and identifies actions that could enhance the field's...

  8. CAMAC based Test Signal Generator using Re-configurable device

    International Nuclear Information System (INIS)

    Sharma, Atish; Raval, Tushar; Srivastava, Amit K; Reddy, D Chenna

    2010-01-01

    There are many different types of signal generators, with different purposes and applications (and at varying levels of expense). In general, no device is suitable for all possible applications. Hence the selection of signal generator is as per requirements. For SST-1 Data Acquisition System requirements, we have developed a CAMAC based Test Signal Generator module using Re-configurable device (CPLD). This module is based on CAMAC interface but can be used for testing both CAMAC and PXI Data Acquisition Systems in SST-1 tokamak. It can also be used for other similar applications. Unlike traditional signal generators, which are embedded hardware, it is a flexible hardware unit, programmable through Graphical User Interface (GUI) developed in LabVIEW application development tool. The main aim of this work is to develop a signal generator for testing our data acquisition interface for a large number of channels simultaneously. The module front panel has various connectors like LEMO and D type connectors for signal interface. The module can be operated either in continuous signal generation mode or in triggered mode depending upon application. This can be done either by front panel switch or through CAMAC software commands (for remote operation). Similarly module reset and trigger generation operation can be performed either through front panel push button switch or through software CAMAC commands. The module has the facility to accept external TTL level trigger and clock through LEMO connectors. The module can also generate trigger and the clock signal, which can be delivered to other devices through LEMO connectors. The module generates two types of signals: Analog and digital (TTL level). The analog output (single channel) is generated from Digital to Analog Converter through CPLD for various types of waveforms like Sine, Square, Triangular and other wave shape that can vary in amplitude as well as in frequency. The module is quite useful to test up to 32 channels

  9. A self-calibrating led-based solar test platform

    DEFF Research Database (Denmark)

    Krebs, Frederik C; Sylvester-Hvid, Kristian O.; Jørgensen, Mikkel

    2011-01-01

    A compact platform for testing solar cells is presented. The light source comprises a multi-wavelength high-power LED (light emitting diode) array allowing the homogenous illumination of small laboratory solar cell devices (substrate size 50 × 25 mm) within the 390–940 nm wavelength range......, it is possible to perform all the commonly employed measurements on the solar cell at very high speed without moving the sample. In particular, the LED-based illumination system provides an alternative to light-biased incident photon-to-current efficiency measurement to be performed which we demonstrate. Both...

  10. Optimisation of test and maintenance based on probabilistic methods

    International Nuclear Information System (INIS)

    Cepin, M.

    2001-01-01

    This paper presents a method, which based on models and results of probabilistic safety assessment, minimises the nuclear power plant risk by optimisation of arrangement of safety equipment outages. The test and maintenance activities of the safety equipment are timely arranged, so the classical static fault tree models are extended with the time requirements to be capable to model real plant states. A house event matrix is used, which enables modelling of the equipment arrangements through the discrete points of time. The result of the method is determination of such configuration of equipment outages, which result in the minimal risk. Minimal risk is represented by system unavailability. (authors)

  11. Water Pollution Detection Based on Hypothesis Testing in Sensor Networks

    Directory of Open Access Journals (Sweden)

    Xu Luo

    2017-01-01

    Full Text Available Water pollution detection is of great importance in water conservation. In this paper, the water pollution detection problems of the network and of the node in sensor networks are discussed. The detection problems in both cases of the distribution of the monitoring noise being normal and nonnormal are considered. The pollution detection problems are analyzed based on hypothesis testing theory firstly; then, the specific detection algorithms are given. Finally, two implementation examples are given to illustrate how the proposed detection methods are used in the water pollution detection in sensor networks and prove the effectiveness of the proposed detection methods.

  12. Ultrasound-based testing of tendon mechanical properties

    DEFF Research Database (Denmark)

    Seynnes, O R; Bojsen-Møller, J.; Albracht, K

    2015-01-01

    In the past 20 years, the use of ultrasound-based methods has become a standard approach to measure tendon mechanical properties in vivo. Yet the multitude of methodological approaches adopted by various research groups probably contribute to the large variability of reported values. The technique......, or signal synchronization; and 2) in physiological considerations related to the viscoelastic behavior or length measurements of tendons. Hence, the purpose of the present review is to assess and discuss the physiological and technical aspects connected to in vivo testing of tendon mechanical properties...

  13. Integration of a Copper-Containing Biohybrid (CuHARS with Cellulose for Subsequent Degradation and Biomedical Control

    Directory of Open Access Journals (Sweden)

    Anik Karan

    2018-04-01

    Full Text Available We previously described the novel synthesis of a copper high-aspect ratio structure (CuHARS biohybrid material using cystine. While extremely stable in water, CuHARS is completely (but slowly degradable in cellular media. Here, integration of the CuHARS into cellulose matrices was carried out to provide added control for CuHARS degradation. Synthesized CuHARS was concentrated by centrifugation and then dried. The weighed mass was re-suspended in water. CuHARS was stable in water for months without degradation. In contrast, 25 μg/mL of the CuHARS in complete cell culture media was completely degraded (slowly in 18 days under physiological conditions. Stable integration of CuHARS into cellulose matrices was achieved through assembly by mixing cellulose micro- and nano-fibers and CuHARS in an aqueous (pulp mixture phase, followed by drying. Additional materials were integrated to make the hybrids magnetically susceptible. The cellulose-CuHARS composite films could be transferred, weighed, and cut into usable pieces; they maintained their form after rehydration in water for at least 7 days and were compatible with cell culture studies using brain tumor (glioma cells. These studies demonstrate utility of a CuHARS-cellulose biohybrid for applied applications including: (1 a platform for biomedical tracking and (2 integration into a 2D/3D matrix using natural products (cellulose.

  14. Cernavoda NPP risk - Based test and maintenance planning - Methodology development

    International Nuclear Information System (INIS)

    Georgescu, G.; Popa, P.; Petrescu, A.; Naum, M.; Gutu, M.

    1997-01-01

    The Cernavoda Power Plant starts the commercial operation in November 1996. During operation of the nuclear power plant, several mandatory tests and maintenance are performed on stand-by safety system components to ensure their availability in case of accident. The basic purpose of such activities is the early detection of any failure and degradation, and timely correction of deteriorations. Because of the large number of such activities, emphasis on plant safety and allocation of resources becomes difficult. The probabilistic model and methodology can be effectively used to obtain the risk significance of these activities so that the resources are directed to the most important areas. The proposed Research Contract activity is strongly connected with other safety related areas under development. Since, the Cernavoda Probabilistic Safety Evaluation Level 1 PSA Study (CPSE) was performed and now the study is revised taking into account the as-built information, it is recommended to implement into the model the necessary modeling features to support further PSA application, especially related to Test and Maintenance optimization. Methods need to be developed in order to apply the PSA model including risk information together with other needed information for Test and Maintenance optimization. Also, in parallel with the CPSE study updating, the software interface for the PSA model is under development (Risk Monitor Software class), methods and models needing to be developed for the purpose of using it for qualified monitoring of Test and Maintenance Strategy efficiency. Similar, the Data Collection System need to be appropriate for the purpose of an ongoing implementation of a risk - based Test and Maintenance Strategy. (author). 4 refs, 1 fig

  15. Harness: Heterogeneous Adaptable Reconfigurable Networked Systems -- U.S. Department of Energy Grant DE-FG02-99ER25379 Final Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Vaidy Sunderam

    2003-07-02

    Issues in reconfigurability and adaptability in heterogeneous distributed systems for high-performance computing are the focus of the work funded by this grant. Our efforts are part of an ongoing research project in metacomputing and are a follow on to the DOE funded PVM system that has witnessed over a decade of use at numerous institutions worldwide. The current project, termed Harness, investigates novel methodologies and tools for distributed metacomputing, focusing on dynamically reconfigurable software frameworks. During the first phase, we defined the metacomputing architecture embodied in Harness and developed prototype subsystems as proof of concept exercises. Subsequently, we designed and developed a complete software framework manifesting the Harness architecture, and also developed several tools and subsystems that demonstrated the viability and effectiveness of our proposed model for next generation metacomputing. We then used this substrate to emulate multiple programming environments on Harness, and conducted performance evaluation and tuning exercises. The main research results from these efforts include the establishment of software metacomputing systems as viable and cost-effective alternatives to MPPs; the demonstration of dynamic and reconfigurable platforms as effective methods of tailoring parallel computing environments; the development of methodologies to construct plugin modules for component-based distributed systems; contributions to performance modeling and optimization in emulated software environments; and software architectures for multi- and mixed-paradigm parallel distributed computing. Details and specifics on these and other results have been reported in numerous publications, and are manifested in software systems, all of which may be accessed at or via the website http://www.mathcs.emory.edu/harness/

  16. Harnessing Cerebrospinal Fluid Biomarkers in Clinical Trials for Treating Alzheimer's and Parkinson's Diseases: Potential and Challenges.

    Science.gov (United States)

    Kim, Dana; Kim, Young Sam; Shin, Dong Wun; Park, Chang Shin; Kang, Ju Hee

    2016-10-01

    No disease-modifying therapies (DMT) for neurodegenerative diseases (NDs) have been established, particularly for Alzheimer's disease (AD) and Parkinson's disease (PD). It is unclear why candidate drugs that successfully demonstrate therapeutic effects in animal models fail to show disease-modifying effects in clinical trials. To overcome this hurdle, patients with homogeneous pathologies should be detected as early as possible. The early detection of AD patients using sufficiently tested biomarkers could demonstrate the potential usefulness of combining biomarkers with clinical measures as a diagnostic tool. Cerebrospinal fluid (CSF) biomarkers for NDs are being incorporated in clinical trials designed with the aim of detecting patients earlier, evaluating target engagement, collecting homogeneous patients, facilitating prevention trials, and testing the potential of surrogate markers relative to clinical measures. In this review we summarize the latest information on CSF biomarkers in NDs, particularly AD and PD, and their use in clinical trials. The large number of issues related to CSF biomarker measurements and applications has resulted in relatively few clinical trials on CSF biomarkers being conducted. However, the available CSF biomarker data obtained in clinical trials support the advantages of incorporating CSF biomarkers in clinical trials, even though the data have mostly been obtained in AD trials. We describe the current issues with and ongoing efforts for the use of CSF biomarkers in clinical trials and the plans to harness CSF biomarkers for the development of DMT and clinical routines. This effort requires nationwide, global, and multidisciplinary efforts in academia, industry, and regulatory agencies to facilitate a new era.

  17. Harnessing solar pressure to slew and point large infrared space telescopes

    Science.gov (United States)

    Errico, Simona; Angel, Roger P.; Calvert, Paul D.; Woof, Neville

    2003-03-01

    Large astronomical Gossamer telescopes in space will need to employ large solar shields to safeguard the optics from solar radiation. These types of telescopes demand accurate controls to maintain telescope pointing over long integration periods. We propose an active solar shield system that harnesses radiation pressure to accurately slew and acquire new targets without the need for reaction wheels or thrusters. To provide the required torques, the solar shield is configured as an inverted, 4-sided pyramidal roof. The sloped roof interior surfaces are covered with hinged “tiles” made from piezoelectric film bimorphs with specular metallized surfaces. Nominally, the tiles lie flat against the roof and the sunlight is reflected outward equally from all sloped surfaces. However, when the tiles on one roof pitch are raised, the pressure balance is upset and the sunshade is pushed to one side. By judicious selection of the tiles and control of their lift angle, the solar pressure can be harvested to stabilize the spacecraft orientation or to change its angular momentum. A first order conceptual design performance analysis and the results from the experimental design, fabrication and testing of piezoelectric bimorph hinge elements will be presented. Next phase challenges in engineering design, materials technology, and systems testing will be discussed.

  18. A PC-based expert system for nondestructive testing

    International Nuclear Information System (INIS)

    Shankar, R.; Williams, R.; Smith, C.; Selby, G.

    1991-01-01

    Rule-based decision logic which can emulate problem-solving expertise of humans is being explored for power plant nondestructive evaluation (NDE) applications. This paper describes an effort underway at the EPRI NDE Center to assist in the interpretation of NDE data acquired by automatic systems during ultrasonic weld examination of boiling-water reactors (BWRs). A personal computer (PC) -based expert system shell was used to encode rules and assemble knowledge to address the discrimination of intergranular stress corrosion cracking (IGSCC) from benign reflectors in the inspection of pipe-to-component welds. The rules attempt to factor in plant inspection history, ultrasonic examination data nd, if available, radiography testing data; a majority of them deal with specific ultrasonic signal temporal and spatial behavior during automatic scanning. The paper describes the efforts in the development of the expert system

  19. Detailed field test of yaw-based wake steering

    DEFF Research Database (Denmark)

    Fleming, P.; Churchfield, M.; Scholbrock, A.

    2016-01-01

    production. In the first phase, a nacelle-mounted scanning lidar was used to verify wake deflection of a misaligned turbine and calibrate wake deflection models. In the second phase, these models were used within a yaw controller to achieve a desired wake deflection. This paper details the experimental......This paper describes a detailed field-test campaign to investigate yaw-based wake steering. In yaw-based wake steering, an upstream turbine intentionally misaligns its yaw with respect to the inflow to deflect its wake away from a downstream turbine, with the goal of increasing total power...... design and setup. All data collected as part of this field experiment will be archived and made available to the public via the U.S. Department of Energy’s Atmosphere to Electrons Data Archive and Portal....

  20. Hvorfor skal Adam betale børnepenge, når Eva har bedraget ham?

    DEFF Research Database (Denmark)

    Petersen, Thomas Søbirk

    2016-01-01

    Juridisk abort bør være en mulighed for mænd, der er blevet bedraget, bestjålet eller som har brugt prævention, der ikke virker efter hensigten.......Juridisk abort bør være en mulighed for mænd, der er blevet bedraget, bestjålet eller som har brugt prævention, der ikke virker efter hensigten....

  1. Tracing the Base: A Topographic Test for Collusive Basing-Point Pricing

    NARCIS (Netherlands)

    Bos, Iwan; Schinkel, Maarten Pieter

    2009-01-01

    Basing-point pricing is known to have been abused by geographically dispersed firms in order to eliminate competition on transportation costs. This paper develops a topographic test for collusive basing-point pricing. The method uses transaction data (prices, quantities) and customer project site

  2. Tracing the base: A topographic test for collusive basing-point pricing

    NARCIS (Netherlands)

    Bos, I.; Schinkel, M.P.

    2008-01-01

    Basing-point pricing is known to have been abused by geographically dispersed firms in order to eliminate competition on transportation costs. This paper develops a topographic test for collusive basing-point pricing. The method uses transaction data (prices, quantities) and customer project site

  3. Molecular mapping of a sunflower rust resistance gene from HAR6.

    Science.gov (United States)

    Bulos, Mariano; Ramos, María L; Altieri, Emiliano; Sala, Carlos A

    2013-03-01

    Sunflower rust, caused by Puccinia helianthi Schw., can result in significant yield losses in cultivated sunflower (Helianthus annuus L. var. macrocarpus Ckll.). HAR6 is a germplasm population resistant to most predominant rust races. The objectives of this study were to map the resistance factor present in HAR6 (R HAR6 ), and to provide and validate molecular tools for the identification of this gene for marker assisted selection purposes. Virulence reaction of seedlings for the F2 population and F2:3 families suggested that a single dominant gene confers rust resistance in HAR6-1, a selected rust resistance line from the original population. Genetic mapping with eight markers covered 97.4 cM of genetic distance on linkage group 13 of the sunflower consensus map. A co-dominant marker ZVG61 is the closest marker distal to R HAR6 at a genetic distance of 0.7 cM, while ORS581, a dominant marker linked in the coupling phase, is proximal to R HAR6 at a genetic distance of 1.5 cM. Validation of these markers was assessed by converting a susceptible line into a rust resistant isoline by means of marker assisted backcrossing. The application of these results to assist the breeding process and to design new strategies for rust control in sunflower is discussed.

  4. Bridge Testing With Ground-Based Interferometric Radar: Experimental Results

    International Nuclear Information System (INIS)

    Chiara, P.; Morelli, A.

    2010-01-01

    The research of innovative non-contact techniques aimed at the vibration measurement of civil engineering structures (also for damage detection and structural health monitoring) is continuously directed to the optimization of measures and methods. Ground-Based Radar Interferometry (GBRI) represents the more recent technique available for static and dynamic control of structures and ground movements.Dynamic testing of bridges and buildings in operational conditions are currently performed: (a) to assess the conformity of the structure to the project design at the end of construction; (b) to identify the modal parameters (i.e. natural frequencies, mode shapes and damping ratios) and to check the variation of any modal parameters over the years; (c) to evaluate the amplitude of the structural response to special load conditions (i.e. strong winds, earthquakes, heavy railway or roadway loads). If such tests are carried out by using a non-contact technique (like GBRI), the classical issues of contact sensors (like accelerometers) are easily overtaken.This paper presents and discusses the results of various tests carried out on full-scale bridges by using a Stepped Frequency-Continuous Wave radar system.

  5. Bridge Testing With Ground-Based Interferometric Radar: Experimental Results

    Science.gov (United States)

    Chiara, P.; Morelli, A.

    2010-05-01

    The research of innovative non-contact techniques aimed at the vibration measurement of civil engineering structures (also for damage detection and structural health monitoring) is continuously directed to the optimization of measures and methods. Ground-Based Radar Interferometry (GBRI) represents the more recent technique available for static and dynamic control of structures and ground movements. Dynamic testing of bridges and buildings in operational conditions are currently performed: (a) to assess the conformity of the structure to the project design at the end of construction; (b) to identify the modal parameters (i.e. natural frequencies, mode shapes and damping ratios) and to check the variation of any modal parameters over the years; (c) to evaluate the amplitude of the structural response to special load conditions (i.e. strong winds, earthquakes, heavy railway or roadway loads). If such tests are carried out by using a non-contact technique (like GBRI), the classical issues of contact sensors (like accelerometers) are easily overtaken. This paper presents and discusses the results of various tests carried out on full-scale bridges by using a Stepped Frequency-Continuous Wave radar system.

  6. Biotechnology to harness the benefits of dietary phenolics; focus on Lamiaceae.

    Science.gov (United States)

    Shetty, K

    1997-09-01

    Phytochemicals from herbs and fermented legumes are excellent dietary sources of phenolic metabolites. These phenolics have importance not only as food preservatives but increasingly have therapeutic and pharmaceutical applications. The long-term research objecitves of the food biotechnology program at the University of Massachusetts are to elucidate the molecular and physiological mechanisms associated with synthesis of important health-related, therapeutic phenolic metabolites in food-related plants and fermented plant foods. Current efforts focus on elucidation of the role of the proline-linked pentose phosphate pathway in regulating the synthesis of anti-inflammatory compound, rosmarinic acid (RA). Specific aims of the current research efforts are: (i) To develop novel tissue culture-based selection techniques to isolate high RA-producing, shoot-based clonal lines from genetically heterogeneous, cross-pollinating species in the family Lamiaceae; (ii) To target genetically uniform, regenerated shoot-based clonal lines for: (a) preliminary characterization of key enzymes associated with the pentose phosphate pathway and linked to RA synthesis; (b) development of genetic transformation techniques for subsequent engineering of metabolic pathways associated with RA synthesis. These research objectives have substantial implications for harnessing the genetic and biochemical potential of genetically heterogeneous, food-related medicinal plant species. The success of this research also provides novel methods and strategies to gain access to metabolic pathways of pharmaceutically important metabolites from ginger, curcuma, chili peppers, melon or other food-related species with novel phenolics.

  7. Blind Test of Physics-Based Prediction of Protein Structures

    Science.gov (United States)

    Shell, M. Scott; Ozkan, S. Banu; Voelz, Vincent; Wu, Guohong Albert; Dill, Ken A.

    2009-01-01

    We report here a multiprotein blind test of a computer method to predict native protein structures based solely on an all-atom physics-based force field. We use the AMBER 96 potential function with an implicit (GB/SA) model of solvation, combined with replica-exchange molecular-dynamics simulations. Coarse conformational sampling is performed using the zipping and assembly method (ZAM), an approach that is designed to mimic the putative physical routes of protein folding. ZAM was applied to the folding of six proteins, from 76 to 112 monomers in length, in CASP7, a community-wide blind test of protein structure prediction. Because these predictions have about the same level of accuracy as typical bioinformatics methods, and do not utilize information from databases of known native structures, this work opens up the possibility of predicting the structures of membrane proteins, synthetic peptides, or other foldable polymers, for which there is little prior knowledge of native structures. This approach may also be useful for predicting physical protein folding routes, non-native conformations, and other physical properties from amino acid sequences. PMID:19186130

  8. Ageing tests study on wood-based sandwich panels

    Directory of Open Access Journals (Sweden)

    Mateo, Raquel

    2011-12-01

    Full Text Available Composite lightweight wood panels are being increasingly used in construction in Spain. Their growing use should be accompanied by necessary guarantees based on studies of their properties. As it is prescriptive and in addition to others tests, in the present work is examinated the durability of these panels when exposed to the climatic conditions, a characteristic of great importance for wood products, according to Guide ETAG 016, the current standard defining the ageing tests to be used. However, due to the use class of this material, there are indications that the testing outlined in this Guide is inappropriate for assessing the ageing of wood-based sandwich panels. Alternative tests are here proposed that recreate rather better the real conditions under which these products are used. Covering the samples in a waterproof sheeting permeable to the outward movement of water vapour, which is in fact used in the installation, provided the best procedure for testing these panels.

    Los paneles sándwich de madera son un producto de creciente aplicación en la edificación de nuestro país. Este ascendente uso del material debe estar acompañado de las garantías necesarias avaladas por un estudio previo de sus prestaciones. Como es preceptivo y entre otros, se evalúa su durabilidad frente a las condiciones climatológicas, clave en los productos derivados de la madera, acorde a la normativa actual definida con tal fin, la Guía ETAG 016. Sin embargo, debido a la clase de uso del material, se ha detectado que dicha normativa tal y como está concebida no es capaz de valorar su envejecimiento adecuadamente. En este trabajo se proponen ensayos alternativos al establecido tras exhaustivos análisis que recrean las condiciones reales de uso y más acordes a los productos de madera. Se concluye que la incorporación de una lámina impermeable pero permeable al vapor de agua hacia el exterior, como las utilizadas en el montaje, aportan el mejor

  9. Drop-in capsule testing of plutonium-based fuels in the Advanced Test Reactor

    International Nuclear Information System (INIS)

    Chang, G.S.; Ryskamp, J.M.; Terry, W.K.; Ambrosek, R.G.; Palmer, A.J.; Roesener, R.A.

    1996-09-01

    The most attractive way to dispose of weapons-grade plutonium (WGPu) is to use it as fuel in existing light water reactors (LWRs) in the form of mixed oxide (MOX) fuel - i.e., plutonia (PuO[sub 2]) mixed with urania (UO[sub 2]). Before U.S. reactors could be used for this purpose, their operating licenses would have to be amended. Numerous technical issues must be resolved before LWR operating licenses can be amended to allow the use of MOX fuel. The proposed weapons-grade MOX fuel is unusual, even relative to ongoing foreign experience with reactor-grade MOX power reactor fuel. Some demonstration of the in- reactor thermal, mechanical, and fission gas release behavior of the prototype fuel will most likely be required in a limited number of test reactor irradiations. The application to license operation with MOX fuel must be amply supported by experimental data. The Advanced Test Reactor (ATR) at the Idaho National Engineering Laboratory (INEL) is capable of playing a key role in the irradiation, development, and licensing of these new fuel types. The ATR is a 250- MW (thermal) LWR designed to study the effects of intense radiation on reactor fuels and materials. For 25 years, the primary role of the ATR has been to serve in experimental investigations for the development of advanced nuclear fuels. Both large- and small-volume test positions in the ATR could be used for MOX fuel irradiation. The ATR would be a nearly ideal test bed for developing data needed to support applications to license LWRs for operation with MOX fuel made from weapons-grade plutonium. Furthermore, these data can be obtained more quickly by using ATR instead of testing in a commercial LWR. Our previous work in this area has demonstrated that it is technically feasible to perform MOX fuel testing in the ATR. This report documents our analyses of sealed drop-in capsules containing plutonium-based test specimens placed in various ATR positions

  10. Quantum spacetime operationally based on propagators for extended test particles

    International Nuclear Information System (INIS)

    Prugovecki, E.

    1981-01-01

    By taking into account the quantum aspects intrinsic to any operational definition of spatio-temporal relationships, a stochastic concept of spacetime emerges. In relation to its classical counterpart is realized as a stochastic mean around which quantum fluctuations become negligible only in the limit of macroscopic spacetime intervals. The test-particle propagators used in the proposed quantum concept of spacetime are derived by solving in a consistent manner the localizability problem for relativistic particles. This is achieved in the framework of the stochastic phase space formulation of quantum mechanics, which in the nonrelativistic context is shown to result from systems of imprimitivity related to phase space conserved probability currents derivable from bona fide convariant probability densities in stochastic phase spaces of one particle systems, which can be interpreted as due to measurements performed with extended rather than pointlike test particles. The associated particle propagators can be therefore consistently related to coordinate probability densities measurable by the exchange of photons in between test particles from a chosen standard. Quantum spacetime is defined as the family of propagators corresponding to all conceivable coherent flows of test particles. This family of free-fall propagators has to satisfy certain self-consistency conditions as well as consistent laws of motion which inplicitly determine the stochastic geometro-dynamics of quantum space-time. Field theory on quantum spacetime retains many of the formal features of conventional quantum field theory. On a fundamental epistemological level stochastic geometries emerge as essential prerequisites in the construction of spacetime models that would be operationally based and yet consistent with the relativity principle as well as with the uncertinty principle

  11. Testing the performance of technical trading rules in the Chinese markets based on superior predictive test

    Science.gov (United States)

    Wang, Shan; Jiang, Zhi-Qiang; Li, Sai-Ping; Zhou, Wei-Xing

    2015-12-01

    Technical trading rules have a long history of being used by practitioners in financial markets. The profitable ability and efficiency of technical trading rules are yet controversial. In this paper, we test the performance of more than seven thousand traditional technical trading rules on the Shanghai Securities Composite Index (SSCI) from May 21, 1992 through June 30, 2013 and China Securities Index 300 (CSI 300) from April 8, 2005 through June 30, 2013 to check whether an effective trading strategy could be found by using the performance measurements based on the return and Sharpe ratio. To correct for the influence of the data-snooping effect, we adopt the Superior Predictive Ability test to evaluate if there exists a trading rule that can significantly outperform the benchmark. The result shows that for SSCI, technical trading rules offer significant profitability, while for CSI 300, this ability is lost. We further partition the SSCI into two sub-series and find that the efficiency of technical trading in sub-series, which have exactly the same spanning period as that of CSI 300, is severely weakened. By testing the trading rules on both indexes with a five-year moving window, we find that during the financial bubble from 2005 to 2007, the effectiveness of technical trading rules is greatly improved. This is consistent with the predictive ability of technical trading rules which appears when the market is less efficient.

  12. Autonomous Cryogenic Load Operations: Knowledge-Based Autonomous Test Engineer

    Science.gov (United States)

    Schrading, J. Nicolas

    2013-01-01

    The Knowledge-Based Autonomous Test Engineer (KATE) program has a long history at KSC. Now a part of the Autonomous Cryogenic Load Operations (ACLO) mission, this software system has been sporadically developed over the past 20 years. Originally designed to provide health and status monitoring for a simple water-based fluid system, it was proven to be a capable autonomous test engineer for determining sources of failure in the system. As part of a new goal to provide this same anomaly-detection capability for a complicated cryogenic fluid system, software engineers, physicists, interns and KATE experts are working to upgrade the software capabilities and graphical user interface. Much progress was made during this effort to improve KATE. A display of the entire cryogenic system's graph, with nodes for components and edges for their connections, was added to the KATE software. A searching functionality was added to the new graph display, so that users could easily center their screen on specific components. The GUI was also modified so that it displayed information relevant to the new project goals. In addition, work began on adding new pneumatic and electronic subsystems into the KATE knowledge base, so that it could provide health and status monitoring for those systems. Finally, many fixes for bugs, memory leaks, and memory errors were implemented and the system was moved into a state in which it could be presented to stakeholders. Overall, the KATE system was improved and necessary additional features were added so that a presentation of the program and its functionality in the next few months would be a success.

  13. Hello, world: Harnessing social media for the Rosetta mission

    Science.gov (United States)

    Baldwin, Emily; Mignone, Claudia; O'Flaherty, Karen; Homfeld, Anne-Mareike; Bauer, Markus; McCaughrean, Mark

    2015-04-01

    The European Space Agency's (ESA) comet-chasing Rosetta mission was launched in 2004, before social media became a popular tool for mainstream communication. By harnessing a range of platforms for communicating the key messages of this unprecedented mission as it reached its destination ten years later, new audiences were reached and a global impact was achieved. Rosetta-specific social media accounts - @ESA_Rosetta on Twitter, the Rosetta Mission Facebook page and the rosettamission Instagram account - were developed during 2013/14 and used alongside the traditional reporting line of the main ESA website and the Rosetta blog to build awareness about the mission. Coordinated with ESA's existing social media channels (Flickr, YouTube, G+, Twitter, Facebook and Livestream) and with the support of ESA's country desks and Rosetta partner agency accounts (including @philae2014), information could be shared in a number of European languages, ensuring a wide reach across Europe - and the world. We discuss the roles of the various social media accounts in supporting and promoting the competitions and social media campaigns that were built around the key mission milestones of 2014: waking up from deep space hibernation (January), arriving at Comet 67P/Churyumov-Gerasimenko (August) and naming the landing site for Philae ahead of the landing event in November. We discuss the different approach to each channel, such as the first person twitter accounts, the dialogue with and between blog users, and the discussions held live via G+ Hangouts with leading scientists and spacecraft operators. We compare and contrast the audiences, the interaction we had with them and how challenges were overcome. We also use the science-fiction-meets-science-fact Ambition short movie, and its "undercover" dissemination on social media, as an example of how the profile of the Rosetta mission was raised in a unique way. By using a variety of social media platforms to target different audiences with

  14. Beam based alignment at the KEK accelerator test facility

    International Nuclear Information System (INIS)

    Ross, M.; Nelson, J.; Woodley, M.; Wolski, A.

    2002-01-01

    The KEK Accelerator Test Facility (ATF) damping ring is a prototype low emittance source for the NLC/JLC linear collider. To achieve the goal normalized vertical emittance gey = 20 nm-rad, magnet placement accuracy better than 30 mm must be achieved. Accurate beam-based alignment (BBA) is required. The ATF arc optics uses a FOBO cell with two horizontally focusing quadrupoles, two sextupoles and a horizontally defocusing gradient dipole, all of which must be aligned with BBA. BBA at ATF uses the quadrupole and sextupole trim windings to find the trajectory through the center of each magnet. The results can be interpreted to assess the accuracy of the mechanical alignment and the beam position monitor offsets

  15. Versatile electrophoresis-based self-test platform.

    Science.gov (United States)

    Guijt, Rosanne M

    2015-03-01

    Lab on a Chip technology offers the possibility to extract chemical information from a complex sample in a simple, automated way without the need for a laboratory setting. In the health care sector, this chemical information could be used as a diagnostic tool for example to inform dosing. In this issue, the research underpinning a family of electrophoresis-based point-of-care devices for self-testing of ionic analytes in various sample matrices is described [Electrophoresis 2015, 36, 712-721.]. Hardware, software, and methodological chances made to improve the overall analytical performance in terms of accuracy, precision, detection limit, and reliability are discussed. In addition to the main focus of lithium monitoring, new applications including the use of the platform for veterinary purposes, sodium, and for creatinine measurements are included. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Deep Unconventional Geothermal Resources: a major opportunity to harness new sources of sustainable energy

    Energy Technology Data Exchange (ETDEWEB)

    Fridleifsson, G.O.; Albertsson, A.; Stefansson, B.; Gunnlaugsson, E.; Adalsteinsson, H.

    2007-07-01

    The Iceland Deep Drilling Project (IDDP) is a long-term program to improve the efficiency and economics of geothermal energy by harnessing Deep Unconventional Geothermal Resources (DUGR). Its aim is to produce electricity from natural supercritical hydrous fluids from drillable depths. Producing supercritical fluids will require drilling wells and sampling fluids and rocks to depths of 3.5 to 5 km, and at temperatures of 450-600{sup o}C. The long-term plan is to drill and test a series of such deep boreholes in Iceland at the Krafla, the Hengill, and the Reykjanes high temperature geothermal systems. Beneath these three developed drill fields temperatures should exceed 550-650{sup o}C, and the occurrence of frequent seismic activity below 5 km, indicates that the rocks are brittle and therefore likely to be permeable. Modeling indicates that if the wellhead enthalpy is to exceed that of conventionally produced geothermal steam, the reservoir temperature must be higher than 450{sup o}C. A deep well producing 0.67 m3/sec steam ({approx}2400 m3/h) from a reservoir with a temperature significantly above 450{sup o}C could yield enough high-enthalpy steam to generate 40-50 MW of electric power. This exceeds by an order of magnitude the power typically obtained from conventional geothermal wells. (auth)

  17. Harnessing Wind Power in Moving Reference Frames with Application to Vehicles

    Science.gov (United States)

    Goushcha, Oleg; Felicissimo, Robert; Danesh-Yazdi, Amir; Andreopoulos, Yiannis

    2017-11-01

    The extraction of wind power from unique configurations embedded in moving vehicles by using micro-turbine devices has been investigated. In such moving environments, the specific power of the air motion is much greater and less intermittent than in stationary wind turbines anchored to the ground in open atmospheric conditions. In a translational frame of reference, the rate of work done by the drag force acting on the wind harnessing device due the relative motion of air should be taken into account in the overall performance evaluation through an energy balance. A device with a venting tube has been tested that connects a high-pressure stagnating flow region in the front of the vehicle with a low-pressure region at its rear. Our analysis identified two key areas to focus on for potentially significant rewards: (1) Vehicles with high energy conversion efficiency which require a high mass flow rate through the venting duct, and (2) low efficiency vehicles with wakes, which will be globally affected by the introduction of the venting duct device in a manner that reduces their drag so that there is a net gain in power generation.

  18. Digital reflection holography based systems development for MEMS testing

    Science.gov (United States)

    Singh, Vijay Raj; Liansheng, Sui; Asundi, Anand

    2010-05-01

    MEMS are tiny mechanical devices that are built onto semiconductor chips and are measured in micrometers and nanometers. Testing of MEMS device is an important part in carrying out their functional assessment and reliability analysis. Development of systems based on digital holography (DH) for MEMS inspection and characterization is presented in this paper. Two DH reflection systems, table-top and handheld types, are developed depending on the MEMS measurement requirements and their capabilities are presented. The methodologies for the systems are developed for 3D profile inspection and static & dynamic measurements, which is further integrated with in-house developed software that provides the measurement results in near real time. The applications of the developed systems are demonstrated for different MEMS devices for 3D profile inspection, static deformation/deflection measurements and vibration analysis. The developed systems are well suitable for the testing of MEMS and Microsystems samples, with full-field, static & dynamic inspection as well as to monitor micro-fabrication process.

  19. Fast Lemons and Sour Boulders: Testing Crossmodal Correspondences Using an Internet-Based Testing Methodology

    Directory of Open Access Journals (Sweden)

    Andy T. Woods

    2013-09-01

    Full Text Available According to a popular family of hypotheses, crossmodal matches between distinct features hold because they correspond to the same polarity on several conceptual dimensions (such as active–passive, good–bad, etc. that can be identified using the semantic differential technique. The main problem here resides in turning this hypothesis into testable empirical predictions. In the present study, we outline a series of plausible consequences of the hypothesis and test a variety of well-established and previously untested crossmodal correspondences by means of a novel internet-based testing methodology. The results highlight that the semantic hypothesis cannot easily explain differences in the prevalence of crossmodal associations built on the same semantic pattern (fast lemons, slow prunes, sour boulders, heavy red; furthermore, the semantic hypothesis only minimally predicts what happens when the semantic dimensions and polarities that are supposed to drive such crossmodal associations are made more salient (e.g., by adding emotional cues that ought to make the good/bad dimension more salient; finally, the semantic hypothesis does not explain why reliable matches are no longer observed once intramodal dimensions with congruent connotations are presented (e.g., visually presented shapes and colour do not appear to correspond.

  20. Diagnostic reliability of MMPI-2 computer-based test interpretations.

    Science.gov (United States)

    Pant, Hina; McCabe, Brian J; Deskovitz, Mark A; Weed, Nathan C; Williams, John E

    2014-09-01

    Reflecting the common use of the MMPI-2 to provide diagnostic considerations, computer-based test interpretations (CBTIs) also typically offer diagnostic suggestions. However, these diagnostic suggestions can sometimes be shown to vary widely across different CBTI programs even for identical MMPI-2 profiles. The present study evaluated the diagnostic reliability of 6 commercially available CBTIs using a 20-item Q-sort task developed for this study. Four raters each sorted diagnostic classifications based on these 6 CBTI reports for 20 MMPI-2 profiles. Two questions were addressed. First, do users of CBTIs understand the diagnostic information contained within the reports similarly? Overall, diagnostic sorts of the CBTIs showed moderate inter-interpreter diagnostic reliability (mean r = .56), with sorts for the 1/2/3 profile showing the highest inter-interpreter diagnostic reliability (mean r = .67). Second, do different CBTIs programs vary with respect to diagnostic suggestions? It was found that diagnostic sorts of the CBTIs had a mean inter-CBTI diagnostic reliability of r = .56, indicating moderate but not strong agreement across CBTIs in terms of diagnostic suggestions. The strongest inter-CBTI diagnostic agreement was found for sorts of the 1/2/3 profile CBTIs (mean r = .71). Limitations and future directions are discussed. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  1. A versatile electrophoresis-based self-test platform.

    Science.gov (United States)

    Staal, Steven; Ungerer, Mathijn; Floris, Arjan; Ten Brinke, Hans-Willem; Helmhout, Roy; Tellegen, Marian; Janssen, Kjeld; Karstens, Erik; van Arragon, Charlotte; Lenk, Stefan; Staijen, Erik; Bartholomew, Jody; Krabbe, Hans; Movig, Kris; Dubský, Pavel; van den Berg, Albert; Eijkel, Jan

    2015-03-01

    This paper reports on recent research creating a family of electrophoresis-based point of care devices for the determination of a wide range of ionic analytes in various sample matrices. These devices are based on a first version for the point-of-care measurement of Li(+), reported in 2010 by Floris et al. (Lab Chip 2010, 10, 1799-1806). With respect to this device, significant improvements in accuracy, precision, detection limit, and reliability have been obtained especially by the use of multiple injections of one sample on a single chip and integrated data analysis. Internal and external validation by clinical laboratories for the determination of analytes in real patients by a self-test is reported. For Li(+) in blood better precision than the standard clinical determination for Li(+) was achieved. For Na(+) in human urine the method was found to be within the clinical acceptability limits. In a veterinary application, Ca(2+) and Mg(2+) were determined in bovine blood by means of the same chip, but using a different platform. Finally, promising preliminary results are reported with the Medimate platform for the determination of creatinine in whole blood and quantification of both cations and anions through replicate measurements on the same sample with the same chip. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Change-based test selection : An empirical evaluation

    NARCIS (Netherlands)

    Soetens, Quinten; Demeyer, Serge; Zaidman, A.E.; Perez, Javier

    2015-01-01

    Regression test selection (i.e., selecting a subset of a given regression test suite) is a problem that has been studied intensely over the last decade. However, with the increasing popularity of developer tests as the driver of the test process, more fine-grained solutions that work well within the

  3. Harnessing CRISPR/Cas systems for programmable transcriptional and post-transcriptional regulation

    KAUST Repository

    Mahas, Ahmed

    2017-11-29

    Genome editing has enabled broad advances and novel approaches in studies of gene function and structure; now, emerging methods aim to precisely engineer post-transcriptional processes. Developing precise, efficient molecular tools to alter the transcriptome holds great promise for biotechnology and synthetic biology applications. Different approaches have been employed for targeted degradation of RNA species in eukaryotes, but they lack programmability and versatility, thereby limiting their utility for diverse applications. The CRISPR/Cas9 system has been harnessed for genome editing in many eukaryotic species and, using a catalytically inactive Cas9 variant, the CRISPR/dCas9 system has been repurposed for transcriptional regulation. Recent studies have used other CRISPR/Cas systems for targeted RNA degradation and RNA-based manipulations. For example, Cas13a, a Type VI-A endonuclease, has been identified as an RNA-guided RNA ribonuclease and used for manipulation of RNA. Here, we discuss different modalities for targeted RNA interference with an emphasis on the potential applications of CRISPR/Cas systems as programmable transcriptional regulators for broad uses, including functional biology, biotechnology, and synthetic biology applications.

  4. A new technology for harnessing the dye polluted water and dye collection in the chemical factory

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A new technology for harnessing the dye polluted water and dyecollection was developed. It is based on the enhanced evaporation by using solar, wind, and air temperature energy and additional heat-electric energy. It consists of four parts: (1) evaporation carrier system (evaporation carrier and frame for evaporation carrier) for polluted water; (2) polluted water circulating system (pumping-spraying-collecting); (3) heating system; (4) workshop with polluted water reservoir-tanks and rainfall prevention roof. The polluted water was (heated in case necessary) sprayed to the evaporation carrier system and the water was evaporated when it moved in the space and downward along the carrier mainly by using natural (solar, wind, and air temperature energy). In case, when there is no roof for the carrier system, thepolluted water can be stored in the reservoirs (storage volume for about 20 days). The first 10-25 mm rainfall also need to be stored in the reservoirs to meet the state standard for discharging wastewater. The dye may be collected at the surface in the reservoir-tanks and the crystallized salt may be collected at the bottom plate. The black-color wastewater released by the factory is no more discharged to the surface water system of Taihu Lake Basin. About 2 kg dye and 200 kg industrial salt may be collected from each tone of the polluted water. The non-pollution production of dye may be realized by using this technology with environmental, economical and social benefits.

  5. Harnessing CRISPR/Cas systems for programmable transcriptional and post-transcriptional regulation

    KAUST Repository

    Mahas, Ahmed; Neal Stewart, C.; Mahfouz, Magdy M.

    2017-01-01

    Genome editing has enabled broad advances and novel approaches in studies of gene function and structure; now, emerging methods aim to precisely engineer post-transcriptional processes. Developing precise, efficient molecular tools to alter the transcriptome holds great promise for biotechnology and synthetic biology applications. Different approaches have been employed for targeted degradation of RNA species in eukaryotes, but they lack programmability and versatility, thereby limiting their utility for diverse applications. The CRISPR/Cas9 system has been harnessed for genome editing in many eukaryotic species and, using a catalytically inactive Cas9 variant, the CRISPR/dCas9 system has been repurposed for transcriptional regulation. Recent studies have used other CRISPR/Cas systems for targeted RNA degradation and RNA-based manipulations. For example, Cas13a, a Type VI-A endonuclease, has been identified as an RNA-guided RNA ribonuclease and used for manipulation of RNA. Here, we discuss different modalities for targeted RNA interference with an emphasis on the potential applications of CRISPR/Cas systems as programmable transcriptional regulators for broad uses, including functional biology, biotechnology, and synthetic biology applications.

  6. Large-area photogrammetry based testing of wind turbine blades

    Science.gov (United States)

    Poozesh, Peyman; Baqersad, Javad; Niezrecki, Christopher; Avitabile, Peter; Harvey, Eric; Yarala, Rahul

    2017-03-01

    An optically based sensing system that can measure the displacement and strain over essentially the entire area of a utility-scale blade leads to a measurement system that can significantly reduce the time and cost associated with traditional instrumentation. This paper evaluates the performance of conventional three dimensional digital image correlation (3D DIC) and three dimensional point tracking (3DPT) approaches over the surface of wind turbine blades and proposes a multi-camera measurement system using dynamic spatial data stitching. The potential advantages for the proposed approach include: (1) full-field measurement distributed over a very large area, (2) the elimination of time-consuming wiring and expensive sensors, and (3) the need for large-channel data acquisition systems. There are several challenges associated with extending the capability of a standard 3D DIC system to measure entire surface of utility scale blades to extract distributed strain, deflection, and modal parameters. This paper only tries to address some of the difficulties including: (1) assessing the accuracy of the 3D DIC system to measure full-field distributed strain and displacement over the large area, (2) understanding the geometrical constraints associated with a wind turbine testing facility (e.g. lighting, working distance, and speckle pattern size), (3) evaluating the performance of the dynamic stitching method to combine two different fields of view by extracting modal parameters from aligned point clouds, and (4) determining the feasibility of employing an output-only system identification to estimate modal parameters of a utility scale wind turbine blade from optically measured data. Within the current work, the results of an optical measurement (one stereo-vision system) performed on a large area over a 50-m utility-scale blade subjected to quasi-static and cyclic loading are presented. The blade certification and testing is typically performed using International

  7. Strategies for Ground Based Testing of Manned Lunar Surface Systems

    Science.gov (United States)

    Beyer, Jeff; Peacock, Mike; Gill, Tracy

    2009-01-01

    Integrated testing (such as Multi-Element Integrated Test (MEIT)) is critical to reducing risks and minimizing problems encountered during assembly, activation, and on-orbit operation of large, complex manned spacecraft. Provides the best implementation of "Test Like You Fly:. Planning for integrated testing needs to begin at the earliest stages of Program definition. Program leadership needs to fully understand and buy in to what integrated testing is and why it needs to be performed. As Program evolves and design and schedules mature, continually look for suitable opportunities to perform testing where enough components are together in one place at one time. The benefits to be gained are well worth the costs.

  8. SB certification handout material requirements, test methods, responsibilities, and minimum classification levels for mixture-based specification for flexible base.

    Science.gov (United States)

    2012-10-01

    A handout with tables representing the material requirements, test methods, responsibilities, and minimum classification levels mixture-based specification for flexible base and details on aggregate and test methods employed, along with agency and co...

  9. Comparing Postsecondary Marketing Student Performance on Computer-Based and Handwritten Essay Tests

    Science.gov (United States)

    Truell, Allen D.; Alexander, Melody W.; Davis, Rodney E.

    2004-01-01

    The purpose of this study was to determine if there were differences in postsecondary marketing student performance on essay tests based on test format (i.e., computer-based or handwritten). Specifically, the variables of performance, test completion time, and gender were explored for differences based on essay test format. Results of the study…

  10. Cloud-Based Electronic Test Procedures, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Procedures are critical to experimental tests as they describe the specific steps necessary to efficiently and safely carry out a test in a repeatable fashion. The...

  11. Tree-Based Global Model Tests for Polytomous Rasch Models

    Science.gov (United States)

    Komboz, Basil; Strobl, Carolin; Zeileis, Achim

    2018-01-01

    Psychometric measurement models are only valid if measurement invariance holds between test takers of different groups. Global model tests, such as the well-established likelihood ratio (LR) test, are sensitive to violations of measurement invariance, such as differential item functioning and differential step functioning. However, these…

  12. PHYTOTOXICOLOGICAL TESTS - APPLICATIONS OF FOILS BASED ON GRAPHENE (GRAPHENE OXIDE

    Directory of Open Access Journals (Sweden)

    Petra ROUPCOVÁ

    2016-12-01

    Full Text Available This paper discusses the problematics of phytotoxicity of chemicals. It mainly focuses on the phytotoxicity of nanomaterials made of graphene. It describes phytotoxicological tests performed with foils from materials belonging to the graphene family. It also describes testing the influence of plants on these films. Furthermore, the paper discusses the issues of mutual influence between plants and tested nanomaterials.

  13. Efficient Test Application for Core-Based Systems Using Twisted-Ring Counters

    OpenAIRE

    Anshuman Chandra; Krishnendu Chakrabarty; Mark C. Hansen

    2001-01-01

    We present novel test set encoding and pattern decompression methods for core-based systems. These are based on the use of twisted-ring counters and offer a number of important advantages–significant test compression (over 10X in many cases), less tester memory and reduced testing time, the ability to use a slow tester without compromising test quality or testing time, and no performance degradation for the core under test. Surprisingly, the encoded test sets obtained from partially-specified...

  14. National Strategies to Harness Information Technology Seeking Transformation in Singapore, Finland, the Philippines, and South Africa

    CERN Document Server

    Knight, Peter

    2012-01-01

    The ability to harness Information Communication Technologies (ICTs) is increasingly at the heart of competitiveness and sustainable growth. As countries engage in an increasingly competitive global economy, they are trying to weave ICT into their development strategies, in the same way enterprises have learned to use ICT to transform their business models and strategies. This integration offers a new path to development that is responsive to the challenges of our times.  In National Strategies to Harness Information Technology, Nagy Hanna and Peter Knight provide a framework for assessing the opportunities, challenges, and prospects for “e-transformation” and for analyzing the options and innovations adopted to manage the e-transformation process.  They ask hard questions: what does it take to harness ICT to transform an economy?  Why some countries accelerate their development journey with ICT while others fail?  How did successful countries balance the need for strategic leadership with bottom up ...

  15. Use of isotopic tools to delimit areas of harnessing for drinking water supply - Final report

    International Nuclear Information System (INIS)

    Gourcy, L.; Petelet-Giraud, E.

    2011-03-01

    Within the frame of an action of the ONEMA-BRGM convention (Methodological approaches and tools for the protection of drinking water harnessing against diffuse pollutions), this study aims at developing a synthesis of isotopic geochemical tools to obtain the information required for the delimitation of harnessing supply areas. The report first describes the conventional tools: water molecule steady isotopes, radioactive isotopes, water dating tools, tools developed for another use, and artificial tracers. It presents the possible uses of natural and artificial tracers to determine parameters like flow directions, water residence duration, exchanges between aquifers and water sheet-river interactions. It gives an overview of knowledge on the use of isotopic methods to determine the origin of contaminants. It proposes a brief overview of a previous study of water sheets-rivers relationships. It finally discusses the use of geochemical and isotopic tools when delimiting supply areas for harnessing aimed at drinking water supply

  16. Science har fundet løsning på CURIS-registrering

    DEFF Research Database (Denmark)

    Mørch, Frede

    2012-01-01

    Fakultetsbibliotekar Frede Mørch fortæller her om den løsning, som Science har indført for at sikre at alle forskningspublikationer bliver registreret i databasen, CURIS, uden at forskerne skal spilde tid på det.......Fakultetsbibliotekar Frede Mørch fortæller her om den løsning, som Science har indført for at sikre at alle forskningspublikationer bliver registreret i databasen, CURIS, uden at forskerne skal spilde tid på det....

  17. Making Cloud-based Systems Elasticity Testing Reproducible

    OpenAIRE

    Albonico , Michel; Mottu , Jean-Marie; Sunyé , Gerson; Alvares , Frederico

    2017-01-01

    International audience; Elastic cloud infrastructures vary computational resources at runtime, i. e., elasticity, which is error-prone. That makes testing throughout elasticity crucial for those systems. Those errors are detected thanks to tests that should run deterministically many times all along the development. However, elasticity testing reproduction requires several features not supported natively by the main cloud providers, such as Amazon EC2. We identify three requirements that we c...

  18. Towards a Development Environment for Model Based Test Design

    OpenAIRE

    Jing, Han

    2008-01-01

    Within the UP IP I&V organization there is high focus on increasing the ability to predict product quality in a cost efficient way. Test automation has therefore been an important enabler for us. The IP test design environment is continuously evolving and the investigations will show which improvements that is most important to implement in short and long term. In Ericsson UP IP I&V, the test automation framework environments are severed to complete some process by automated method, f...

  19. TerraFERMA: Harnessing Advanced Computational Libraries in Earth Science

    Science.gov (United States)

    Wilson, C. R.; Spiegelman, M.; van Keken, P.

    2012-12-01

    Many important problems in Earth sciences can be described by non-linear coupled systems of partial differential equations. These "multi-physics" problems include thermo-chemical convection in Earth and planetary interiors, interactions of fluids and magmas with the Earth's mantle and crust and coupled flow of water and ice. These problems are of interest to a large community of researchers but are complicated to model and understand. Much of this complexity stems from the nature of multi-physics where small changes in the coupling between variables or constitutive relations can lead to radical changes in behavior, which in turn affect critical computational choices such as discretizations, solvers and preconditioners. To make progress in understanding such coupled systems requires a computational framework where multi-physics problems can be described at a high-level while maintaining the flexibility to easily modify the solution algorithm. Fortunately, recent advances in computational science provide a basis for implementing such a framework. Here we present the Transparent Finite Element Rapid Model Assembler (TerraFERMA), which leverages several advanced open-source libraries for core functionality. FEniCS (fenicsproject.org) provides a high level language for describing the weak forms of coupled systems of equations, and an automatic code generator that produces finite element assembly code. PETSc (www.mcs.anl.gov/petsc) provides a wide range of scalable linear and non-linear solvers that can be composed into effective multi-physics preconditioners. SPuD (amcg.ese.ic.ac.uk/Spud) is an application neutral options system that provides both human and machine-readable interfaces based on a single xml schema. Our software integrates these libraries and provides the user with a framework for exploring multi-physics problems. A single options file fully describes the problem, including all equations, coefficients and solver options. Custom compiled applications are

  20. Test Setup for Anechoic Room based MIMO OTA Testing of LTE Terminals

    DEFF Research Database (Denmark)

    Carreño, Xavier; Fan, Wei; Nielsen, Jesper Ødum

    2013-01-01

    introduced into, for example, LTE andWiMAX systems. The main purpose of this testing is to validate that the user equipment will have a good performance in real use. CTIA, 3GPP and COST are spending a big effort in standardizing the OTA testing procedure which is much more complex than similar SISO OTA...... the activities related to the MIMO OTA lab being built at Aalborg University (AAU), Denmark and the testing being performed....

  1. Training Senior Teachers in Compulsory Computer Based Language Tests

    Science.gov (United States)

    Laborda, Jesus Garcia; Royo, Teresa Magal

    2009-01-01

    The IBT TOEFL has become the principal example of online high stakes language testing since 2005. Most instructors who do the preparation for IBT TOEFL face two main realities: first, students are eager and highly motivated to take the test because of the prospective implications; and, second, specific studies would be necessary to see if…

  2. Confidence Testing for Knowledge-Based Global Communities

    Science.gov (United States)

    Jack, Brady Michael; Liu, Chia-Ju; Chiu, Houn-Lin; Shymansky, James A.

    2009-01-01

    This proposal advocates the position that the use of confidence wagering (CW) during testing can predict the accuracy of a student's test answer selection during between-subject assessments. Data revealed female students were more favorable to taking risks when making CW and less inclined toward risk aversion than their male counterparts. Student…

  3. CUSUM-based person-fit statistics for adaptive testing

    NARCIS (Netherlands)

    van Krimpen-Stoop, Edith; Meijer, R.R.

    1999-01-01

    Item scores that do not fit an assumed item response theory model may cause the latent trait value to be estimated inaccurately. Several person-fit statistics for detecting nonfitting score patterns for paper-and-pencil tests have been proposed. In the context of computerized adaptive tests (CAT),

  4. CUSUM-based person-fit statistics for adaptive testing

    NARCIS (Netherlands)

    van Krimpen-Stoop, Edith; Meijer, R.R.

    2001-01-01

    Item scores that do not fit an assumed item response theory model may cause the latent trait value to be inaccurately estimated. Several person-fit statistics for detecting nonfitting score patterns for paper-and-pencil tests have been proposed. In the context of computerized adaptive tests (CAT),

  5. The application and testing of diatom-based indices of stream water ...

    African Journals Online (AJOL)

    The application and testing of diatom-based indices of stream water quality in Chinhoyi Town, Zimbabwe. ... PROMOTING ACCESS TO AFRICAN RESEARCH ... test the applicability of foreign diatom-based water quality assessment indices to ...

  6. The HARNESS Workbench: Unified and Adaptive Access to Diverse HPC Platforms

    Energy Technology Data Exchange (ETDEWEB)

    Sunderam, Vaidy S.

    2012-03-20

    The primary goal of the Harness WorkBench (HWB) project is to investigate innovative software environments that will help enhance the overall productivity of applications science on diverse HPC platforms. Two complementary frameworks were designed: one, a virtualized command toolkit for application building, deployment, and execution, that provides a common view across diverse HPC systems, in particular the DOE leadership computing platforms (Cray, IBM, SGI, and clusters); and two, a unified runtime environment that consolidates access to runtime services via an adaptive framework for execution-time and post processing activities. A prototype of the first was developed based on the concept of a 'system-call virtual machine' (SCVM), to enhance portability of the HPC application deployment process across heterogeneous high-end machines. The SCVM approach to portable builds is based on the insertion of toolkit-interpretable directives into original application build scripts. Modifications resulting from these directives preserve the semantics of the original build instruction flow. The execution of the build script is controlled by our toolkit that intercepts build script commands in a manner transparent to the end-user. We have applied this approach to a scientific production code (Gamess-US) on the Cray-XT5 machine. The second facet, termed Unibus, aims to facilitate provisioning and aggregation of multifaceted resources from resource providers and end-users perspectives. To achieve that, Unibus proposes a Capability Model and mediators (resource drivers) to virtualize access to diverse resources, and soft and successive conditioning to enable automatic and user-transparent resource provisioning. A proof of concept implementation has demonstrated the viability of this approach on high end machines, grid systems and computing clouds.

  7. Specification-based testing: What is it? How can it be automated?

    International Nuclear Information System (INIS)

    Poston, R.M.

    1994-01-01

    Software testing should begin with a written requirements specification. A specification states how software is expected to behave and describes operational characteristics (performance, reliability, etc.) for the software. A specification serves as a reference or base to test against, giving rise to the name, specification-based testing. Should analysts or designers fail to write a specification, then testers are obliged to write their own specification to test against. Specifications written by testers may be called test plans or test objectives

  8. Reducing test-data volume and test-power simultaneously in LFSR reseeding-based compression environment

    Energy Technology Data Exchange (ETDEWEB)

    Wang Weizheng; Kuang Jishun; You Zhiqiang; Liu Peng, E-mail: jshkuang@163.com [College of Information Science and Engineering, Hunan University, Changsha 410082 (China)

    2011-07-15

    This paper presents a new test scheme based on scan block encoding in a linear feedback shift register (LFSR) reseeding-based compression environment. Meanwhile, our paper also introduces a novel algorithm of scan-block clustering. The main contribution of this paper is a flexible test-application framework that achieves significant reductions in switching activity during scan shift and the number of specified bits that need to be generated via LFSR reseeding. Thus, it can significantly reduce the test power and test data volume. Experimental results using Mintest test set on the larger ISCAS'89 benchmarks show that the proposed method reduces the switching activity significantly by 72%-94% and provides a best possible test compression of 74%-94% with little hardware overhead. (semiconductor integrated circuits)

  9. A Quantitative Analysis of Evidence-Based Testing Practices in Nursing Education

    Science.gov (United States)

    Moore, Wendy

    2017-01-01

    The focus of this dissertation is evidence-based testing practices in nursing education. Specifically, this research study explored the implementation of evidence-based testing practices between nursing faculty of various experience levels. While the significance of evidence-based testing in nursing education is well documented, little is known…

  10. Updating the Duplex Design for Test-Based Accountability in the Twenty-First Century

    Science.gov (United States)

    Bejar, Isaac I.; Graf, E. Aurora

    2010-01-01

    The duplex design by Bock and Mislevy for school-based testing is revisited and evaluated as a potential platform in test-based accountability assessments today. We conclude that the model could be useful in meeting the many competing demands of today's test-based accountability assessments, although many research questions will need to be…

  11. Development, construct validity and test-retest reliability of a field-based wheelchair mobility performance test for wheelchair basketball

    NARCIS (Netherlands)

    de Witte, Annemarie M. H.; Hoozemans, Marco J. M.; Berger, Monique A. M.; van der Slikke, Rienk M. A.; van der Woude, Lucas H. V.; Veeger, Dirkjan (H. E. J)

    2018-01-01

    The aim of this study was to develop and describe a wheelchair mobility performance test in wheelchair basketball and to assess its construct validity and reliability. To mimic mobility performance of wheelchair basketball matches in a standardised manner, a test was designed based on observation of

  12. Non-Destructive Techniques Based on Eddy Current Testing

    Science.gov (United States)

    García-Martín, Javier; Gómez-Gil, Jaime; Vázquez-Sánchez, Ernesto

    2011-01-01

    Non-destructive techniques are used widely in the metal industry in order to control the quality of materials. Eddy current testing is one of the most extensively used non-destructive techniques for inspecting electrically conductive materials at very high speeds that does not require any contact between the test piece and the sensor. This paper includes an overview of the fundamentals and main variables of eddy current testing. It also describes the state-of-the-art sensors and modern techniques such as multi-frequency and pulsed systems. Recent advances in complex models towards solving crack-sensor interaction, developments in instrumentation due to advances in electronic devices, and the evolution of data processing suggest that eddy current testing systems will be increasingly used in the future. PMID:22163754

  13. Cloud-based Electronic Test Procedures, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Test procedures are at the heart of any experimental process, especially those involving novel and complex hardware. Whether these procedures are for system...

  14. FPGA based mixed-signal circuit novel testing techniques

    International Nuclear Information System (INIS)

    Pouros, Sotirios; Vassios, Vassilios; Papakostas, Dimitrios; Hristov, Valentin

    2013-01-01

    Electronic circuits fault detection techniques, especially on modern mixed-signal circuits, are evolved and customized around the world to meet the industry needs. The paper presents techniques used on fault detection in mixed signal circuits. Moreover, the paper involves standardized methods, along with current innovations for external testing like Design for Testability (DfT) and Built In Self Test (BIST) systems. Finally, the research team introduces a circuit implementation scheme using FPGA

  15. Development of microcomputer-based mental acuity tests

    Science.gov (United States)

    Turnage, J. J.; Kennedy, R. S.; Smith, M. G.; Baltzley, D. R.; Lane, N. E.

    1992-01-01

    Recent disasters have focused attention on performance problems due to the use of alcohol and controlled substances in the workplace. Environmental stressors such as thermal extremes, mixed gases, noise, motion, and vibration also have adverse effects on human performance and operator efficiency. However, the lack of a standardized, sensitive, human performance assessment battery has probably delayed the systematic study of the deleterious effects of various toxic chemicals and drugs at home and in the workplace. The collective goal of the research reported here is the development of a menu of tests embedded in a coherent package of hardware and software that may be useful in repeated-measures studies of a broad range of agents that can degrade human performance. A menu of 40 tests from the Automated Performance Test System (APTS) is described, and the series of interlocking studies supporting its development is reviewed. The APTS tests, which run on several versions of laptop portables and desktop personal computers, have been shown to be stable, reliable, and factorially rich, and to have predictive validities with holistic measures of intelligence and simulator performances. In addition, sensitivity studies have been conducted in which performance changes due to stressors, agents, and treatments were demonstrated. We believe that tests like those described here have prospective use as an adjunct to urine testing for the screening for performance loss of individuals who are granted access to workplaces and stations that impact public safety.

  16. A Fuzzy Logic Based Method for Analysing Test Results

    Directory of Open Access Journals (Sweden)

    Le Xuan Vinh

    2017-11-01

    Full Text Available Network operators must perform many tasks to ensure smooth operation of the network, such as planning, monitoring, etc. Among those tasks, regular testing of network performance, network errors and troubleshooting is very important. Meaningful test results will allow the operators to evaluate network performanceof any shortcomings and to better plan for network upgrade. Due to the diverse and mainly unquantifiable nature of network testing results, there is a needs to develop a method for systematically and rigorously analysing these results. In this paper, we present STAM (System Test-result Analysis Method which employs a bottom-up hierarchical processing approach using Fuzzy logic. STAM is capable of combining all test results into a quantitative description of the network performance in terms of network stability, the significance of various network erros, performance of each function blocks within the network. The validity of this method has been successfully demonstrated in assisting the testing of a VoIP system at the Research Instiute of Post and Telecoms in Vietnam. The paper is organized as follows. The first section gives an overview of fuzzy logic theory the concepts of which will be used in the development of STAM. The next section describes STAM. The last section, demonstrating STAM’s capability, presents a success story in which STAM is successfully applied.

  17. Fem sociale medier har »uindskrænket ret« til at misbruge alt dit indhold

    DEFF Research Database (Denmark)

    Nielsen, Jøren Ullits Olai

    2016-01-01

    Ved du, hvor meget kontrol du har over dit indhold på Facebook, YouTube, Snapchat, Instagram og Twitter? Her giver en juraforsker dig det forkromede overblik.......Ved du, hvor meget kontrol du har over dit indhold på Facebook, YouTube, Snapchat, Instagram og Twitter? Her giver en juraforsker dig det forkromede overblik....

  18. Warming Up to Trade? Harnessing International Trade to Support Climate Change Objectives

    OpenAIRE

    World Bank

    2007-01-01

    This study on harnessing international trade to support climate change objectives assesses the following: 1) What are the main policy prescriptions for reducing greenhouse gases that are employed by OECD countries and how do they impact the competitiveness of their energy-intensive industries? 2) On account of the impact on competitiveness, is there is leakage of energy intensive industrie...

  19. Secondary geochemical reactions in hydrothermal energy harnessing; Geochemische Folgereaktionen bei der hydrogeothermalen Energiegewinnung

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, M.

    1996-12-01

    This thesis is in six parts: description of geothermal energy harnessing, analytics, geochemical-thermodynamic modellings, experimental investigations, discussion of results, summary. (HW) [Deutsch] Die vorliegende Dissertationsschrift gliedert sich in 6 Teile: - Beschreibung der geothermischen Energienutzung - Analytik - geochemische-thermodynamische Modellierungen - experimentelle Untersuchungen - Diskussion der Ergebnisse - Zusammenfassung. (HW)

  20. Taso Mähar : maali ümber ehitatud maja / Gitte Hint

    Index Scriptorium Estoniae

    Hint, Gitte

    2003-01-01

    220-ruutmeetrise ühekorde eramu sisekujundus. Arhitekt Emil Urbel. Sisearhitekt Taso Mähar, tema kommentaarid. Köögimööbel on T. Mähari projekteeritud. Elutoas mööblifirma T&T Mang pehme mööbel, seinal Lemming Nageli maal "Punane joon all - Burn Out". Ill.: plaan, 17 värv. vaadet

  1. Universities plan revolution in research; Four institutes will harness top brains

    CERN Multimedia

    Buie, E

    2003-01-01

    "Scotland is on the brink of revolutionising its approach to university research by creating four institutions that would harness the country's top brains to work together in specific areas. The move to create pan-academic institutes in physics, life-sciences, economics and creative arts has won the backing of the principals of every higher education institution in Scotland..." (1 page).

  2. The Facebook-in-Action: Challenging, Harnessing and Enhancing Students Class Assignments and Projects

    Science.gov (United States)

    Saifudin, Adam Mohd; Yacob, Aizan; Saad, Rohaizah

    2016-01-01

    Issues of universities students harnessing and capitalizing the usage of Facebook for their own learning capabilities and effective thinking is always the focus of education scholars, in assessing the quality class assignments and projects produced by them. Therefore, Facebook is now becoming unbearable influence since the internet activation in…

  3. Unge er en flok egoistiske individualister, der har nok i sig selv

    DEFF Research Database (Denmark)

    Kofod, Anne

    2005-01-01

     Nutidens unge har som oftest en tvetydig identitet: På én og samme tid søger de sammen i sociale fællesskaber og gør alt for at skille sig ud som individualister.   Udgivelsesdato: 27. september...

  4. Harnessing the plurality of actor frames in social-ecological systems : Ecological sanitation in Bolivia

    NARCIS (Netherlands)

    Eelderink, M.; Vervoort, J.; Snel, D.; de Castro, F.

    2017-01-01

    This article uses a case study on ecological sanitation as a basis for lessons on identifying and harnessing the plurality of actor frames in social-ecological systems, thereby moving beyond the advocacy positions often taken by implementing NGOs. The study aimed to explore how perspectives between

  5. Harnessing the power of big data: infusing the scientific method with machine learning to transform ecology

    Science.gov (United States)

    Most efforts to harness the power of big data for ecology and environmental sciences focus on data and metadata sharing, standardization, and accuracy. However, many scientists have not accepted the data deluge as an integral part of their research because the current scientific method is not scalab...

  6. Research Problems Associated with Limiting the Applied Force in Vibration Tests and Conducting Base-Drive Modal Vibration Tests

    Science.gov (United States)

    Scharton, Terry D.

    1995-01-01

    The intent of this paper is to make a case for developing and conducting vibration tests which are both realistic and practical (a question of tailoring versus standards). Tests are essential for finding things overlooked in the analyses. The best test is often the most realistic test which can be conducted within the cost and budget constraints. Some standards are essential, but the author believes more in the individual's ingenuity to solve a specific problem than in the application of standards which reduce problems (and technology) to their lowest common denominator. Force limited vibration tests and base-drive modal tests are two examples of realistic, but practical testing approaches. Since both of these approaches are relatively new, a number of interesting research problems exist, and these are emphasized herein.

  7. Leach test of six 192-iridium pellets based on the IAEA 'special form' test procedures

    International Nuclear Information System (INIS)

    Gordon, G.; Gerdingh, R.

    1981-07-01

    The designation 'special form' may be applied to indispersible solid radioactive material if the material meets the requirements of the tests described in the International Atomic Energy Agency Regulations for the Safe Transport of Radioactive Type Materials. This report presents the procedures and results of a leach test performed as specified in the regulations on 6 'as received' active 192-iridium pellets. Mechanical tests were not carried out prior to or following the leach test. The activity of each of the first 6 water baths was found to be between 2.3 and 12.6 μCi, (8.5 x 10 4 and 4.7 x 10 5 Bq) and of the second 6, between 1.3 to 6.0 μCi, (4.8 x 10 4 to 2.2 x 10 5 Bq) thus exceeding the allowable limit

  8. Cyber-Physical Energy Systems Modeling, Test Specification, and Co-Simulation Based Testing

    DEFF Research Database (Denmark)

    van der Meer, A. A.; Palensky, P.; Heussen, Kai

    2017-01-01

    The gradual deployment of intelligent and coordinated devices in the electrical power system needs careful investigation of the interactions between the various domains involved. Especially due to the coupling between ICT and power systems a holistic approach for testing and validating is required....... Taking existing (quasi-) standardised smart grid system and test specification methods as a starting point, we are developing a holistic testing and validation approach that allows a very flexible way of assessing the system level aspects by various types of experiments (including virtual, real......, and mixed lab settings). This paper describes the formal holistic test case specification method and applies it to a particular co-simulation experimental setup. The various building blocks of such a simulation (i.e., FMI, mosaik, domain-specific simulation federates) are covered in more detail...

  9. Harnessing the atoms, for a better future, for all

    International Nuclear Information System (INIS)

    Daud Mohamad; Rehir Dahalan; Md Shahid Ayub

    1995-01-01

    This article reviews some recent development and activities in nuclear technology research in Malaysia. It is covers all activities in utilization of radiations and radioisotopes in industry, medicine, agriculture, etc. The topics reviewed are tracer technology, nucleonic control system, nondestructive testing, radiation processing, radiotherapy, radiotherapeutics, radiopharmaceutical, single photon emission tomography and radiation sterilization of medical products

  10. Research on Generating Method of Embedded Software Test Document Based on Dynamic Model

    Science.gov (United States)

    Qu, MingCheng; Wu, XiangHu; Tao, YongChao; Liu, Ying

    2018-03-01

    This paper provides a dynamic model-based test document generation method for embedded software that provides automatic generation of two documents: test requirements specification documentation and configuration item test documentation. This method enables dynamic test requirements to be implemented in dynamic models, enabling dynamic test demand tracking to be easily generated; able to automatically generate standardized, standardized test requirements and test documentation, improved document-related content inconsistency and lack of integrity And other issues, improve the efficiency.

  11. Technical bases for establishing a salt test facility

    International Nuclear Information System (INIS)

    1985-05-01

    The need for a testing facility in which radioactive materials may be used in an underground salt environment is explored. No such facility is currently available in salt deposits in the United States. A salt test facility (STF) would demonstrate the feasibility of safely storing radioactive waste in salt and would provide data needed to support the design, construction, licensing, and operation of a radioactive waste repository in salt. Nineteen issues that could affect long-term isolation of waste materials in a salt repository are identified from the most pertinent recent literature. The issues are assigned an overall priority and a priority relative to the activities of the STF. Individual tests recommended for performance in the STF to resolve the 19 issues are described and organized under three groups: waste package performance, repository design and operation, and site characterization and evaluation. The requirements for a salt test facility are given in the form of functional criteria, and the approach that will be used in the design, execution, interpretation, and reporting of tests is discussed

  12. Harnessing diversity towards the reconstructing of large scale gene regulatory networks.

    Directory of Open Access Journals (Sweden)

    Takeshi Hase

    Full Text Available Elucidating gene regulatory network (GRN from large scale experimental data remains a central challenge in systems biology. Recently, numerous techniques, particularly consensus driven approaches combining different algorithms, have become a potentially promising strategy to infer accurate GRNs. Here, we develop a novel consensus inference algorithm, TopkNet that can integrate multiple algorithms to infer GRNs. Comprehensive performance benchmarking on a cloud computing framework demonstrated that (i a simple strategy to combine many algorithms does not always lead to performance improvement compared to the cost of consensus and (ii TopkNet integrating only high-performance algorithms provide significant performance improvement compared to the best individual algorithms and community prediction. These results suggest that a priori determination of high-performance algorithms is a key to reconstruct an unknown regulatory network. Similarity among gene-expression datasets can be useful to determine potential optimal algorithms for reconstruction of unknown regulatory networks, i.e., if expression-data associated with known regulatory network is similar to that with unknown regulatory network, optimal algorithms determined for the known regulatory network can be repurposed to infer the unknown regulatory network. Based on this observation, we developed a quantitative measure of similarity among gene-expression datasets and demonstrated that, if similarity between the two expression datasets is high, TopkNet integrating algorithms that are optimal for known dataset perform well on the unknown dataset. The consensus framework, TopkNet, together with the similarity measure proposed in this study provides a powerful strategy towards harnessing the wisdom of the crowds in reconstruction of unknown regulatory networks.

  13. Harnessing Geographic Information Systems (GIS) to enable community-oriented primary care.

    Science.gov (United States)

    Bazemore, Andrew; Phillips, Robert L; Miyoshi, Thomas

    2010-01-01

    settings, particularly if the hurdles of cost and technological expertise are overcome by harnessing new advances in web-based mapping technology.

  14. Epidemiology of musculoskeletal injuries in a population of harness Standardbred racehorses in training

    Science.gov (United States)

    2014-01-01

    Background There is a substantial paucity of studies concerning musculoskeletal injuries in harness Standardbred racehorses. Specifically, little is known about the epidemiology of exercise-related musculoskeletal injuries. Most studies on this subject involve Thoroughbred racehorses, whose biomechanics and racing speed differ from Standardbred, making comparisons difficult. Here, a population of Standardbred racehorses trained at the same racecourse was studied over four years and a classification system for exercise-related musculoskeletal injuries was designed. The incidence rates of musculoskeletal injuries causing horses’ withdrawal from training for 15 days or longer were investigated. A mixed-effects Poisson regression model was used to estimate musculoskeletal injury rates and to describe significance of selected risk factors for exercise-related injuries in this population. Results A total of 356 trotter racehorses from 10 different stables contributed 8961 months at risk of musculoskeletal injuries. Four-hundred-and-twenty-nine injuries were reported and classified into 16 categories, based on their aetiology and anatomical localisation. The overall exercise-related injury rate was 4.79 per 100 horse months. When considering risk factors one by one in separate univariable analyses, we obtained the following results: rates did not differ significantly between genders and classes of age, whereas one driver seemed to cause fewer injuries than the others. Racing speed and racing intensity, as well as recent medical history, seemed to be significant risk factors (p fracture are lower in Standardbreds compared to Thoroughbreds, whereas the opposite is true for tendon and suspensory ligament injuries. In addition to identification of risk factors for musculoskeletal injuries among Standardbred racehorses, results suggest that racing intensity seems to be a protective predictor of risk and recent medical history could be used to identify horses at risk of

  15. USING COMPUTER-BASED TESTING AS ALTERNATIVE ASSESSMENT METHOD OF STUDENT LEARNING IN DISTANCE EDUCATION

    Directory of Open Access Journals (Sweden)

    Amalia SAPRIATI

    2010-04-01

    Full Text Available This paper addresses the use of computer-based testing in distance education, based on the experience of Universitas Terbuka (UT, Indonesia. Computer-based testing has been developed at UT for reasons of meeting the specific needs of distance students as the following: Ø students’ inability to sit for the scheduled test, Ø conflicting test schedules, and Ø students’ flexibility to take examination to improve their grades. In 2004, UT initiated a pilot project in the development of system and program for computer-based testing method. Then in 2005 and 2006 tryouts in the use of computer-based testing methods were conducted in 7 Regional Offices that were considered as having sufficient supporting recourses. The results of the tryouts revealed that students were enthusiastic in taking computer-based tests and they expected that the test method would be provided by UT as alternative to the traditional paper and pencil test method. UT then implemented computer-based testing method in 6 and 12 Regional Offices in 2007 and 2008 respectively. The computer-based testing was administered in the city of the designated Regional Office and was supervised by the Regional Office staff. The development of the computer-based testing was initiated with conducting tests using computers in networked configuration. The system has been continually improved, and it currently uses devices linked to the internet or the World Wide Web. The construction of the test involves the generation and selection of the test items from the item bank collection of the UT Examination Center. Thus the combination of the selected items compromises the test specification. Currently UT has offered 250 courses involving the use of computer-based testing. Students expect that more courses are offered with computer-based testing in Regional Offices within easy access by students.

  16. Thermography Used to Test Conductivity of Carbon Based Cloth

    Science.gov (United States)

    Craven, Paul

    2012-01-01

    Testing of the ability of carbon fiber to radiatively cool a heat source. The carbon fibers are attached to a heat source. The heat conducts into the fiber than along the fiber away from the heat source. The test are done in a vacuum chamber (10-5 Torr typical). The IR camera is viewing the fiber through a ZnSe window. A thermocouple (TC) in contact with the fiber is at the top right hand side of the area of interest and one is near the bottom. Thin shielding fins, seen edge on, are just above the top thermocouple.

  17. A Web-Based Learning System for Software Test Professionals

    Science.gov (United States)

    Wang, Minhong; Jia, Haiyang; Sugumaran, V.; Ran, Weijia; Liao, Jian

    2011-01-01

    Fierce competition, globalization, and technology innovation have forced software companies to search for new ways to improve competitive advantage. Web-based learning is increasingly being used by software companies as an emergent approach for enhancing the skills of knowledge workers. However, the current practice of Web-based learning is…

  18. Life estimation I and C cable insulation materials based on accelerated life testing accelerated life testing

    International Nuclear Information System (INIS)

    Santhosh, T.V.; Ramteke, P.K.; Shrestha, N.B.; Ahirwar, A.K.; Gopika, V.

    2016-01-01

    Accelerated Iife tests are becoming increasingly popular in today's industry due to the need for obtaining life data quickly and reliably. Life testing of products under higher stress levels without introducing additional failure modes can provide significant savings of both time and money. Correct analysis of data gathered via such accelerated life testing will yield parameters and other information for the product's life under use stress conditions. To be of practical use in assessing the operational behaviour of cables in NPPs, laboratory ageing aims to mimic the type of degradation observed under operational conditions. Conditions of testing therefore need to be carefully chosen to ensure that the degradation mechanism occurring in the accelerated tests are similar to those which occur in service. This paper presents the results of an investigation in which the elongation-at-break (EAB) measurements were carried on a typical control cable to predict the mean life at service conditions. A low voltage polyvinyl chloride (PVC) insulated and PVC sheathed control cable, used in NPP instrumentation and control (I and C) applications, was subjected thermal ageing at three elevated temperatures

  19. Test-based approach to cable tray support system analysis and design: Behavior and test methods

    Energy Technology Data Exchange (ETDEWEB)

    Reigles, Damon G., E-mail: dreigles@engnovex.com [engNoveX, Inc., 19C Trolley Square, Wilmington, DE 19806 (United States); Brachmann, Ingo; Johnson, William H. [Bechtel Nuclear, Security & Environmental, 12011 Sunset Hills Rd, Suite 110, Reston, VA 20190 (United States); Gürbüz, Orhan [Tobolski Watkins Engineering, Inc., 4125 Sorrento Valley Blvd, Suite B, San Diego, CA 92121 (United States)

    2016-06-15

    Highlights: • Describes dynamic response behavior of unistrut type cable tray supports. • Summarizes observations from past full-scale shake table test programs. • Outlines testing methodologies necessary to identify key system parameters. - Abstract: Nuclear power plant safety-related cable tray support systems subjected to seismic loadings were originally understood and designed to behave as linear elastic systems. This behavioral paradigm persisted until the early 1980s when, due to evolution of regulatory criteria, some as-installed systems needed to be qualified to higher seismic motions than originally designed for. This requirement prompted a more in-depth consideration of the true seismic response behavior of support systems. Several utilities initiated extensive test programs, which demonstrated that trapeze strut-type cable tray support systems exhibited inelastic and nonlinear response behaviors with plastic hinging at the connections together with high damping due to bouncing of cables in the trays. These observations were used to demonstrate and justify the seismic adequacy of the aforementioned as-installed systems. However, no formalized design methodology or criteria were ever established to facilitate use of these test data for future evaluations. This paper assimilates and reviews the various test data and conclusions for the purpose of developing a design methodology for the seismic qualification of safety-related cable tray support systems.

  20. Chronological Trends in Negev Rock Art: The Har Michia Petroglyphs as a Test Case

    Directory of Open Access Journals (Sweden)

    Davida Eisenberg-Degen

    2013-10-01

    Full Text Available Negev rock art comprises a large and diverse corpus of motifs and compositions developed over the course of several millennia. As dating of specific elements is at present not possible, the rock art was analyzed statistically through the study of individual panels where internal sequences of engraving could be discerned. Examining the set of such individual sequences, larger scale reconstruction of engraving phases, sequences and patterns were recognized. Additional chronological markers, such as the presence of domestic camels or other chronologically diagnostic features, offer benchmarks for tying the general trends to more absolute frameworks. The reconstructed patterns reflect the long term history of the Negev and some of the most significant cultural and social transitions in the region are reflected visually through the rock art, notably a form of self-expression, a crucial complement to the historical sequences derived from sedentary peoples living farther north. For example the introduction of the domestic camel and its symbolic and economic significance is well evident in the rock art. Similarly, the emergence of Islam is expressed through the mark makers’ preference for "abstract" (non-figurative motifs. One motif found throughout all engraving phases, transcending the religious, political and economic structures of Negev society, is the “ibex”. Although Negev societies have all focused, to one degree or another, on sheep and goat pastoralism, these animals are rarely present in the Negev rock art and never as herds. Ibex, whose role in the diet and daily subsistence was minimal, was the most commonly depicted zoomorphic motif.

  1. A critical comparison of respirometric biodegradation tests based on OECD 301 and related test methods.

    Science.gov (United States)

    Reuschenbach, Peter; Pagga, Udo; Strotmann, Uwe

    2003-04-01

    Biodegradation studies of organic compounds in the aquatic environment gain important information for the final fate of chemicals in the environment. A decisive role play tests for ready biodegradability (OECD 301) and in this context, the respirometric test (OECD 301F). Two different respirometric systems (Oxitop and Sapromat) were compared and in two of ten cases (diethylene glycol and 2-ethylhexylacrylate) differences were observed indicating that the test systems are not always equivalent. For 2-ethylhexylacrylate and cyclohexanone we could not state differences in the extent of biodegradation with a municipal and industrial inoculum whereas for cyclohexanone the degradation rate was faster with a municipal inoculum. Allylthiourea (ATU) proved to be an effective inhibitor of nitrification processes and did not affect the heterotrophic biodegradation activity. Modelling of biodegradation processes could be successfully performed with a first-order and a modified logistic plot. Copyright 2002 Elsevier Science Ltd.

  2. Test Standards for Contingency Base Waste-to-Energy Technologies

    Science.gov (United States)

    2015-08-01

    test runs are preferred to allow a more comprehensive statistical evaluation of the results. In 8 • Minimize the complexity , difficulty, and...with water or, in the case of cyanide - or sulfide-bearing wastes, when exposed to mild acidic or basic conditions; 4) explode when subjected to a

  3. Operational Based Vision Assessment Cone Contrast Test: Description and Operation

    Science.gov (United States)

    2016-06-02

    time and even between monitors from the same manufacturer. Because of this, the system will include a colorimeter that can test the system to see if...it is in the proper state. If the system is out of calibration, the colorimeter and custom software can be used to return the system to the

  4. Improved Accelerated Stress Tests Based on Fuel Cell Vehicle Data

    Energy Technology Data Exchange (ETDEWEB)

    Patterson, Timothy [Research Engineer; Motupally, Sathya [Research Engineer

    2012-06-01

    UTC will led a top-tier team of industry and national laboratory participants to update and improve DOE’s Accelerated Stress Tests (AST’s) for hydrogen fuel cells. This in-depth investigation will focused on critical fuel cell components (e.g. membrane electrode assemblies - MEA) whose durability represented barriers for widespread commercialization of hydrogen fuel cell technology. UTC had access to MEA materials that had accrued significant load time under real-world conditions in PureMotion® 120 power plant used in transit buses. These materials are referred to as end-of-life (EOL) components in the rest of this document. Advanced characterization techniques were used to evaluate degradation mode progress using these critical cell components extracted from both bus power plants and corresponding materials tested using the DOE AST’s. These techniques were applied to samples at beginning-of-life (BOL) to serve as a baseline. These comparisons advised the progress of the various failure modes that these critical components were subjected to, such as membrane degradation, catalyst support corrosion, platinum group metal dissolution, and others. Gaps in the existing ASTs predicted the degradation observed in the field in terms of these modes were outlined. Using the gaps, new AST’s were recommended and tested to better reflect the degradation modes seen in field operation. Also, BOL components were degraded in a test vehicle at UTC designed to accelerate the bus field operation.

  5. Certification Testing as an Illustration of Argument-Based Validation

    Science.gov (United States)

    Kane, Michael

    2004-01-01

    The theories of validity developed over the past 60 years are quite sophisticated, but the methodology of validity is not generally very effective. The validity evidence for major testing programs is typically much weaker than the evidence for more technical characteristics such as reliability. In addition, most validation efforts have a strong…

  6. Inverted base pavements : new field test and design catalogue.

    Science.gov (United States)

    2014-01-01

    The current economic situation has severely affected the US road infrastructure and funding has become : inadequate for either maintenance or future growth. : The inverted base pavement structure is a promising alternative to achieve high quality roa...

  7. The Art Gallery Test: A Preliminary Comparison between Traditional Neuropsychological and Ecological VR-Based Tests

    Directory of Open Access Journals (Sweden)

    Pedro Gamito

    2017-11-01

    Full Text Available Ecological validity should be the cornerstone of any assessment of cognitive functioning. For this purpose, we have developed a preliminary study to test the Art Gallery Test (AGT as an alternative to traditional neuropsychological testing. The AGT involves three visual search subtests displayed in a virtual reality (VR art gallery, designed to assess visual attention within an ecologically valid setting. To evaluate the relation between AGT and standard neuropsychological assessment scales, data were collected on a normative sample of healthy adults (n = 30. The measures consisted of concurrent paper-and-pencil neuropsychological measures [Montreal Cognitive Assessment (MoCA, Frontal Assessment Battery (FAB, and Color Trails Test (CTT] along with the outcomes from the three subtests of the AGT. The results showed significant correlations between the AGT subtests describing different visual search exercises strategies with global and specific cognitive measures. Comparative visual search was associated with attention and cognitive flexibility (CTT; whereas visual searches involving pictograms correlated with global cognitive function (MoCA.

  8. Test-Access Planning and Test Scheduling for Embedded Core-Based System Chips

    NARCIS (Netherlands)

    Goel, Sandeep Kumar

    2005-01-01

    Advances in the semiconductor process technology enable the creation of a complete system on one single die, the so-called system chip or SOC. To reduce time-to-market for large SOCs, reuse of pre-designed and pre-veried blocks called cores is employed. Like the design style, testing of SOCs can be

  9. The Memory Stack: New Technologies Harness Talking for Writing.

    Science.gov (United States)

    Gannon, Maureen T.

    In this paper, an elementary school teacher describes her experiences with the Memory Stack--a HyperCard based tool that can accommodate a voice recording, a graphic image, and a written text on the same card--which she designed to help her second and third grade students integrate their oral language fluency into the process of learning how to…

  10. Harnessing cell-material interaction to control cell fate: design ...

    Indian Academy of Sciences (India)

    Rajat K Das

    2017-10-26

    Oct 26, 2017 ... cytoplasmic domain is believed to be the crucial step for the activation of integrins and .... These gels can be degraded both via hydrolysis as well as enzymolysis. Thus, the ... tions.25,26 In one of the early examples of synthetic, proteolytically ... poly(ethylene glycol) (PEG) based gels with MMP degradable ...

  11. Repair mortars based on lime. Accelerated aging tests

    Directory of Open Access Journals (Sweden)

    Martínez-Ramírez, S.

    1995-06-01

    Full Text Available The behaviour under different accelerated aging tests (freeze/thaw and crystallization cycles of a new lime mortar with biocide properties destinated to monumental repair has been studied. New mortars (which have the biocide impregnated in a clay called sepiolite have a similar behaviour to lime mortars used as a reference. After the aging tests, the biocide properties of the mortars have been tried.

    Se ha estudiado el comportamiento frente a distintos ensayos de envejecimiento acelerado (ciclos de hielo/deshielo y cristalización de sales de un nuevo mortero de cal con propiedades biocidas, destinado a la reparación monumental. Se ha comprobado que los nuevos morteros (que llevan incorporado el biocida impregnado en una arcilla denominada sepiolita tienen un comportamiento muy similar a los morteros de cal utilizados como referencia. Tras los ensayos de envejecimiento se ha visto que las propiedades biocidas de los morteros se mantienen.

  12. Optimal Combinations of Diagnostic Tests Based on AUC.

    Science.gov (United States)

    Huang, Xin; Qin, Gengsheng; Fang, Yixin

    2011-06-01

    When several diagnostic tests are available, one can combine them to achieve better diagnostic accuracy. This article considers the optimal linear combination that maximizes the area under the receiver operating characteristic curve (AUC); the estimates of the combination's coefficients can be obtained via a nonparametric procedure. However, for estimating the AUC associated with the estimated coefficients, the apparent estimation by re-substitution is too optimistic. To adjust for the upward bias, several methods are proposed. Among them the cross-validation approach is especially advocated, and an approximated cross-validation is developed to reduce the computational cost. Furthermore, these proposed methods can be applied for variable selection to select important diagnostic tests. The proposed methods are examined through simulation studies and applications to three real examples. © 2010, The International Biometric Society.

  13. PSO Based Optimization of Testing and Maintenance Cost in NPPs

    Directory of Open Access Journals (Sweden)

    Qiang Chou

    2014-01-01

    Full Text Available Testing and maintenance activities of safety equipment have drawn much attention in Nuclear Power Plant (NPP to risk and cost control. The testing and maintenance activities are often implemented in compliance with the technical specification and maintenance requirements. Technical specification and maintenance-related parameters, that is, allowed outage time (AOT, maintenance period and duration, and so forth, in NPP are associated with controlling risk level and operating cost which need to be minimized. The above problems can be formulated by a constrained multiobjective optimization model, which is widely used in many other engineering problems. Particle swarm optimizations (PSOs have proved their capability to solve these kinds of problems. In this paper, we adopt PSO as an optimizer to optimize the multiobjective optimization problem by iteratively trying to improve a candidate solution with regard to a given measure of quality. Numerical results have demonstrated the efficiency of our proposed algorithm.

  14. Earthquake acceleration amplification based on single microtremor test

    Science.gov (United States)

    Jaya Syahbana, Arifan; Kurniawan, Rahmat; Soebowo, Eko

    2018-02-01

    Understanding soil dynamics is needed to understand soil behaviour, including the parameters of earthquake acceleration amplification. Many researchers now conduct single microtremor tests to obtain amplification of velocity and natural periods of soil at test sites. However, these amplification parameters are rarely used, so a method is needed to convert the velocity amplification to acceleration amplification. This paper will discuss the proposed process of changing the value of amplification. The proposed method is to integrate the time histories of the synthetic earthquake acceleration of the soil surface under the deaggregation at that location so the time histories of the velocity earthquake will be obtained. Next is to conduct a “fitting curve” between amplification by a single microtremor test with amplification of the synthetic earthquake velocity time histories. After obtaining the fitting curve time histories of velocity, differentiation will be conducted to obtain fitting curve acceleration time histories. The final step after obtaining the fitting curve is to compare the acceleration of the “fitting curve” against the histories time of the acceleration of synthetic earthquake at bedrocks to obtain single microtremor acceleration amplification factor.

  15. Using Video in Web-Based Listening Tests

    Directory of Open Access Journals (Sweden)

    Cristina Pardo-Ballester

    2016-07-01

    Full Text Available With sophisticated multimedia technology, there is a renewed interest in the relationship between visual and auditory channels in assessing listening comprehension (LC. Research on the use of visuals in assessing listening has emerged with inconclusive results. Some learners perform better on tests which include visual input (Wagner, 2007 while others have found no difference in the performance of participants on the two test formats (Batty, 2015. These mixed results make it necessary to examine the role of using audio and video in LC as measured by L2 listening tests. The current study examined the effects of two different types of listening support on L2 learners’ comprehension: (a visual aid in a video with input modified with redundancy and (b no visuals (audio-only input with input modified with redundancy. The participants of this study included 246 Spanish students enrolled in two different intermediate Spanish courses at a large Midwestern university who participated in four listening tasks either with video or with audio. Findings of whether the video serves as a listening support device and whether the course formats differ on intermediate-level Spanish learners’ comprehension will be shared as well as participants’ preferences with respect to listening support.

  16. An investigation of the statistical power of neutrality tests based on comparative and population genetic data

    DEFF Research Database (Denmark)

    Zhai, Weiwei; Nielsen, Rasmus; Slatkin, Montgomery

    2009-01-01

    In this report, we investigate the statistical power of several tests of selective neutrality based on patterns of genetic diversity within and between species. The goal is to compare tests based solely on population genetic data with tests using comparative data or a combination of comparative...... and population genetic data. We show that in the presence of repeated selective sweeps on relatively neutral background, tests based on the d(N)/d(S) ratios in comparative data almost always have more power to detect selection than tests based on population genetic data, even if the overall level of divergence...... selection. The Hudson-Kreitman-Aguadé test is the most powerful test for detecting positive selection among the population genetic tests investigated, whereas McDonald-Kreitman test typically has more power to detect negative selection. We discuss our findings in the light of the discordant results obtained...

  17. Clinician-led improvement in cancer care (CLICC) - testing a multifaceted implementation strategy to increase evidence-based prostate cancer care: phased randomised controlled trial - study protocol

    Science.gov (United States)

    2014-01-01

    Background Clinical practice guidelines have been widely developed and disseminated with the aim of improving healthcare processes and patient outcomes but the uptake of evidence-based practice remains haphazard. There is a need to develop effective implementation methods to achieve large-scale adoption of proven innovations and recommended care. Clinical networks are increasingly being viewed as a vehicle through which evidence-based care can be embedded into healthcare systems using a collegial approach to agree on and implement a range of strategies within hospitals. In Australia, the provision of evidence-based care for men with prostate cancer has been identified as a high priority. Clinical audits have shown that fewer than 10% of patients in New South Wales (NSW) Australia at high risk of recurrence after radical prostatectomy receive guideline recommended radiation treatment following surgery. This trial will test a clinical network-based intervention to improve uptake of guideline recommended care for men with high-risk prostate cancer. Methods/Design In Phase I, a phased randomised cluster trial will test a multifaceted intervention that harnesses the NSW Agency for Clinical Innovation (ACI) Urology Clinical Network to increase evidence-based care for men with high-risk prostate cancer following surgery. The intervention will be introduced in nine NSW hospitals over 10 months using a stepped wedge design. Outcome data (referral to radiation oncology for discussion of adjuvant radiotherapy in line with guideline recommended care or referral to a clinical trial of adjuvant versus salvage radiotherapy) will be collected through review of patient medical records. In Phase II, mixed methods will be used to identify mechanisms of provider and organisational change. Clinicians’ knowledge and attitudes will be assessed through surveys. Process outcome measures will be assessed through document review. Semi-structured interviews will be conducted to elucidate

  18. Toward a superconducting quantum computer. Harnessing macroscopic quantum coherence.

    Science.gov (United States)

    Tsai, Jaw-Shen

    2010-01-01

    Intensive research on the construction of superconducting quantum computers has produced numerous important achievements. The quantum bit (qubit), based on the Josephson junction, is at the heart of this research. This macroscopic system has the ability to control quantum coherence. This article reviews the current state of quantum computing as well as its history, and discusses its future. Although progress has been rapid, the field remains beset with unsolved issues, and there are still many new research opportunities open to physicists and engineers.

  19. Microbes at Surface-Air Interfaces: The Metabolic Harnessing of Relative Humidity, Surface Hygroscopicity, and Oligotrophy for Resilience

    Science.gov (United States)

    Stone, Wendy; Kroukamp, Otini; Korber, Darren R.; McKelvie, Jennifer; Wolfaardt, Gideon M.

    2016-01-01

    The human environment is predominantly not aqueous, and microbes are ubiquitous at the surface-air interfaces with which we interact. Yet microbial studies at surface-air interfaces are largely survival-oriented, whilst microbial metabolism has overwhelmingly been investigated from the perspective of liquid saturation. This study explored microbial survival and metabolism under desiccation, particularly the influence of relative humidity (RH), surface hygroscopicity, and nutrient availability on the interchange between these two phenomena. The combination of a hygroscopic matrix (i.e., clay or 4,000 MW polyethylene glycol) and high RH resulted in persistent measurable microbial metabolism during desiccation. In contrast, no microbial metabolism was detected at (a) hygroscopic interfaces at low RH, and (b) less hygroscopic interfaces (i.e., sand and plastic/glass) at high or low RH. Cell survival was conversely inhibited at high RH and promoted at low RH, irrespective of surface hygroscopicity. Based on this demonstration of metabolic persistence and survival inhibition at high RH, it was proposed that biofilm metabolic rates might inversely influence whole-biofilm resilience, with ‘resilience’ defined in this study as a biofilm’s capacity to recover from desiccation. The concept of whole-biofilm resilience being promoted by oligotrophy was supported in desiccation-tolerant Arthrobacter spp. biofilms, but not in desiccation-sensitive Pseudomonas aeruginosa biofilms. The ability of microbes to interact with surfaces to harness water vapor during desiccation was demonstrated, and potentially to harness oligotrophy (the most ubiquitous natural condition facing microbes) for adaptation to desiccation. PMID:27746774

  20. Test, dannelse og faglighed

    DEFF Research Database (Denmark)

    Schou, Lotte Rahbek

    2013-01-01

    Erfaringer fra blandt andet USA viser, at indførelse af obligatoriske nationale test får stor betydning for, hvilke former for faglighed der bliver dominerende i skolens undervisning. Hensigten har været at styrke de former for viden, som faktisk kan testes – ikke på bekostning af andre vidensfor...... vidensformer og indsigter - men simpelthen for blot at blive bedre til de dele af fagligheden, som kan testes. Forskning peger dog på, at obligatoriske test ikke blot styrker dele af fagligheden, men snarere bliver fuldstændig determinerende for hele fagligheden.......Erfaringer fra blandt andet USA viser, at indførelse af obligatoriske nationale test får stor betydning for, hvilke former for faglighed der bliver dominerende i skolens undervisning. Hensigten har været at styrke de former for viden, som faktisk kan testes – ikke på bekostning af andre...

  1. Harnessing the privatisation of China's fragmented health-care delivery.

    Science.gov (United States)

    Yip, Winnie; Hsiao, William

    2014-08-30

    Although China's 2009 health-care reform has made impressive progress in expansion of insurance coverage, much work remains to improve its wasteful health-care delivery. Particularly, the Chinese health-care system faces substantial challenges in its transformation from a profit-driven public hospital-centred system to an integrated primary care-based delivery system that is cost effective and of better quality to respond to the changing population needs. An additional challenge is the government's latest strategy to promote private investment for hospitals. In this Review, we discuss how China's health-care system would perform if hospital privatisation combined with hospital-centred fragmented delivery were to prevail--population health outcomes would suffer; health-care expenditures would escalate, with patients bearing increasing costs; and a two-tiered system would emerge in which access and quality of care are decided by ability to pay. We then propose an alternative pathway that includes the reform of public hospitals to pursue the public interest and be more accountable, with public hospitals as the benchmarks against which private hospitals would have to compete, with performance-based purchasing, and with population-based capitation payment to catalyse coordinated care. Any decision to further expand the for-profit private hospital market should not be made without objective assessment of its effect on China's health-policy goals. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Computer-Based English Language Testing in China: Present and Future

    Science.gov (United States)

    Yu, Guoxing; Zhang, Jing

    2017-01-01

    In this special issue on high-stakes English language testing in China, the two articles on computer-based testing (Jin & Yan; He & Min) highlight a number of consistent, ongoing challenges and concerns in the development and implementation of the nationwide IB-CET (Internet Based College English Test) and institutional computer-adaptive…

  3. Humidifying system design of PEMFC test platform based on the mixture of dry and wet air

    Directory of Open Access Journals (Sweden)

    Tiancai Ma

    2015-01-01

    Full Text Available Based on the present humidifying system of PEMFC test platform, a novel design based on dry and wet air mixture is proposed. Key parameters are calculated, and test platform is built. Three experiments are implemented to test the performance of proposed design. Results show that the new design can meet the requirements, and realize the quick response and accurate control.

  4. 75 FR 32484 - Array-Based Cytogenetic Tests: Questions on Performance Evaluation, Result Reporting and...

    Science.gov (United States)

    2010-06-08

    ...] Array-Based Cytogenetic Tests: Questions on Performance Evaluation, Result Reporting and Interpretation... public meeting: Array-Based Cytogenetic Tests: Questions on Performance Evaluation, Result Reporting and... cytogenetic tests. Date and Time: The meeting will be held on June 30, 2010, from 1:30 p.m. to 5 p.m. Location...

  5. Tests of a silicon wafer based neutron collimator

    International Nuclear Information System (INIS)

    Cussen, L.D.; Vale, C.J.; Anderson, I.S.; Hoeghoj, P.

    2001-01-01

    A Soller slit neutron collimator has been prepared by stacking 160 μm thick single crystal silicon wafers coated on one surface with 4 μm of gadolinium metal. The collimator has an angular width of 20 min full width at half maximum and an effective length of 2.75 cm. The collimator has beam dimensions of 1 cm wide by 5.3 cm high. Tests at neutron wavelengths 7.5A and 1.8A showed a peak transmission of 88% within 2% of the optimum theoretical possibility. The background suppression in the wings is comparable with that of conventional neutron collimators

  6. Tests of a silicon wafer based neutron collimator

    CERN Document Server

    Cussen, L D; Anderson, I S; Hoeghoj, P

    2001-01-01

    A Soller slit neutron collimator has been prepared by stacking 160 mu m thick single crystal silicon wafers coated on one surface with 4 mu m of gadolinium metal. The collimator has an angular width of 20 min full width at half maximum and an effective length of 2.75 cm. The collimator has beam dimensions of 1 cm wide by 5.3 cm high. Tests at neutron wavelengths 7.5A and 1.8A showed a peak transmission of 88% within 2% of the optimum theoretical possibility. The background suppression in the wings is comparable with that of conventional neutron collimators.

  7. Model-based development and testing of advertising messages

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino

    2000-01-01

    The implementation of valid and comprehensible guidelines for message development potentially enhances the effects of advertising messages and improves the possibility of measuring such effects. Moreover, such guidelines also have potential implications for the managerial communication processes...... (client-agency and intra-agency) involved in the development of advertising messages. The purpose of the study described in this paper is to compare the development and effects of two campaign proposals, with the common aim of increasing the consumption of apples among young Danes (18 to 35 years of age......-test with the target group (n=500), as well as interviews with the involved advertising agency and client2 staff....

  8. Testing the equality of nonparametric regression curves based on ...

    African Journals Online (AJOL)

    Abstract. In this work we propose a new methodology for the comparison of two regression functions f1 and f2 in the case of homoscedastic error structure and a fixed design. Our approach is based on the empirical Fourier coefficients of the regression functions f1 and f2 respectively. As our main results we obtain the ...

  9. A Hybrid Positioning Method Based on Hypothesis Testing

    DEFF Research Database (Denmark)

    Amiot, Nicolas; Pedersen, Troels; Laaraiedh, Mohamed

    2012-01-01

    maxima. We propose to first estimate the support region of the two peaks of the likelihood function using a set membership method, and then decide between the two regions using a rule based on the less reliable observations. Monte Carlo simulations show that the performance of the proposed method...

  10. Active Fault Detection Based on a Statistical Test

    DEFF Research Database (Denmark)

    Sekunda, André Krabdrup; Niemann, Hans Henrik; Poulsen, Niels Kjølstad

    2016-01-01

    In this paper active fault detection of closed loop systems using dual Youla-Jabr-Bongiorno-Kucera(YJBK) parameters is presented. Until now all detector design for active fault detection using the dual YJBK parameters has been based on CUSUM detectors. Here a method for design of a matched filter...

  11. Technological innovations in mental healthcare: harnessing the digital revolution.

    Science.gov (United States)

    Hollis, Chris; Morriss, Richard; Martin, Jennifer; Amani, Sarah; Cotton, Rebecca; Denis, Mike; Lewis, Shôn

    2015-04-01

    Digital technology has the potential to transform mental healthcare by connecting patients, services and health data in new ways. Digital online and mobile applications can offer patients greater access to information and services and enhance clinical management and early intervention through access to real-time patient data. However, substantial gaps exist in the evidence base underlying these technologies. Greater patient and clinician involvement is needed to evaluate digital technologies and ensure they target unmet needs, maintain public trust and improve clinical outcomes. Royal College of Psychiatrists.

  12. A calibration mechanism based on the principles of the Michelson interferometer micro-thrust test device

    Science.gov (United States)

    Yan, Biao; Wang, Hai; Yang, Chunlai; Wen, Li

    2017-08-01

    A micro-thrust test system based on Michelson interferometer was proposed and tested. The relationship between thrust and output voltage of the calibration component in the system was calculated and verified with numerical modeling. The fitting function of the calibration component was obtained, which will be tested during future thrust test experiments.

  13. Mechanical Testing of Carbon Based Woven Thermal Protection Materials

    Science.gov (United States)

    Pham, John; Agrawal, Parul; Arnold, James O.; Peterson, Keith; Venkatapathy, Ethiraj

    2013-01-01

    Three Dimensional Woven thermal protection system (TPS) materials are one of the enabling technologies for mechanically deployable hypersonic decelerator systems. These materials have been shown capable of serving a dual purpose as TPS and as structural load bearing members during entry and descent operations. In order to ensure successful structural performance, it is important to characterize the mechanical properties of these materials prior to and post exposure to entry-like heating conditions. This research focuses on the changes in load bearing capacity of woven TPS materials after being subjected to arcjet simulations of entry heating. Preliminary testing of arcjet tested materials [1] has shown a mechanical degradation. However, their residual strength is significantly more than the requirements for a mission to Venus [2]. A systematic investigation at the macro and microstructural scales is reported here to explore the potential causes of this degradation. The effects of heating on the sizing (an epoxy resin coating used to reduce friction and wear during fiber handling) are discussed as one of the possible causes for the decrease in mechanical properties. This investigation also provides valuable guidelines for margin policies for future mechanically deployable entry systems.

  14. IELTS as a Literacy-Based Proficiency Test

    Directory of Open Access Journals (Sweden)

    Sugeng Purwanto

    2012-08-01

    Full Text Available This is an exploratory case study aimed at investigating whether or not International English Language Testing Systems (IELTS scores correspond with literacy levels. During the 2011-2012 academic year, 20 first semester students in the English Literature Program in the Faculty of Language and Cultural Studies (Fakultas Bahasa dan Ilmu Budaya at Universitas Stikubank (UNISBANK were randomly selected to take the IELTS. Results were matched against predetermined criteria for literacy levels (Hammond, et al. 1992 in order to classify them into the appropriate levels of literacy. Findings indicate that all students (100 percent were at the performative level of literacy with respect to their overall IELTS scores. Only 25 percent of the students on the speaking subtest and 20 percent of the students on the reading subtest managed to test at the functional level. It is therefore recommended that action research be conducted in Central Java level to upgrade the level of literacy from the performative level up to the informative level. As well, similar research may be conducted with a multi-disciplinary approach employing a correlational study between IELTS band scores with literacy levels.

  15. STRESS TESTS FOR VIDEOSTREAMING SERVICES BASED ON RTSP PROTOCOL

    Directory of Open Access Journals (Sweden)

    Gabriel Elías Chanchí Golondrino

    2015-11-01

    Full Text Available Video-streaming is a technology with major implications these days in such diverse contexts as education, health and the business sector; all of this regarding the ease it provides for remote access to live or recorded media content, allowing communication regardless of geographic location. One standard protocol that enables implementation of this technology is real time streaming protocol, or RTSP. However, since most application servers and Internet services are supported on HTTP requests, very little research has been done on generating tools for carrying out stress tests on streaming servers. This paper presents a stress measuring tool called Hermes, developed in Python, which allows calculation of response times for establishing RTSP connections to streaming servers, as well as obtaining RAM memory consumption and CPU usage rate data from these servers. Hermes was deployed in a video-streaming environment where stress testing was carried out on the LIVE555 server, using calls in the background to VLC and OpenRTSP open source clients. 

  16. Rolling contact fatigue testing of peek based composites

    Directory of Open Access Journals (Sweden)

    Petrogalli C.

    2010-06-01

    Full Text Available Rolling contact fatigue phenomenon was investigated on unfilled PEEK and on three different PEEK composites: 10% carbon micro-fiber, graphite and PTFE filled matrix, 30% carbon micro-fiber filled matrix, 30% glass micro-fiber filled matrix. For this aim, roller-shaped specimens were machined from extruded bars of these materials and subjected to rolling contact tests at different contact pressure levels by means of a four roller machine. Contact pressure-life diagrams and wear rates were so obtained and compared, highlighting a relationship with monotonic and hardness materials properties. Microscopic observations of contact surfaces and transversal section of the specimens also allowed observing the damage mechanisms occurred in the materials tested and the effects of the filler. In particular way, deep radial cracks appeared on unfilled PEEK, while spalling and delamination phenomena where found on composites. Diffuse microcracks were found at the filler-matrix interface of the composites specimens, confirming that the fatigue life of these materials is essentially determined by the crack propagation phase, also under rolling contact loading.

  17. Harnessing the Sun with Thin Film Photovoltaics: Preprint

    International Nuclear Information System (INIS)

    Birkmire, R. W.; Kazmerski, L. L.

    1999-01-01

    Photovoltaic (PV) technologies have a substantial role in meeting electric power needs in the next century, especially with an expected competitive position compared to conventional power-generation and other renewable- energy technologies. Thin-film photovoltaic modules based on CdTe, CuInSe2 or Si can potentially be produced by economical, high-volume manufacturing techniques, dramatically reducing component cost. However, the translation of laboratory thin-film technologies to first-time, large-scale manufacturing has been much more difficult than expected. This is due to the complexity of the processes involved for making large-area PV modules at high rates and with high yields, and compounded by the lack of a fundamental scientific and engineering base required to properly engineer and operate manufacturing equipment. In this paper, we discuss the need to develop diagnostics tools and associated predictive models that quantitatively assess processing conditions and pro duct properties. Incorporation of the diagnostic sensors into both laboratory reactors and manufacturing facilities will (1) underpin the development of solar cells with improved efficiency, and (2) accelerate the scale-up process through intelligent process-control schemes. ''Next-generation'' high-performance (e.g., and gt;25% conversion efficiency) thin-film PV modules will also be assessed, along with critical issues associated with their development

  18. ADC multi-site test based on a pre-test with digital input stimulus

    NARCIS (Netherlands)

    Sheng, Xiaoqin; Metra, C.; Kerkhoff, Hans G.; Zjajo, Amir; Gronthoud, Guido

    2012-01-01

    This paper describes two novel algorithms based on the time-modulo reconstruction method intended for detection of the parametric faults in analogue-to-digital converters (ADC). In both algorithms, a pulse signal, in its slightly adapted form to allow sufficient time for converter settling, is taken

  19. Harnessing Photovoice for tuberculosis advocacy in Karachi, Pakistan.

    Science.gov (United States)

    Mohammed, Shama; Sajun, Sana Zehra; Khan, Faisal S

    2015-06-01

    In Pakistan, despite publically available free testing and treatment throughout the country, there were an estimated 58,000 deaths due to tuberculosis in 2010. Understanding the experiences of people affected by TB is essential in addressing barriers to effective treatment. The Indus Hospital used Photovoice to understand the experiences of people affected by TB in Karachi. Two hundred and thirty photographs and stories were collected from 55 people affected by TB. Five major themes and 12 sub-themes emerged from the data: the physical aspects of TB (weakness and the side effects of the medication), the social aspects of TB (loneliness, stigma, and the fear/guilt of infecting family members), the socio-economic aspects of TB (financial difficulties/poverty and poor living conditions), supportive factors during treatment (support from family and friends, support from welfare organizations, prayer, visiting peaceful places), and recovery (happiness about getting better). The photographs, stories, and a Call for Action were shared at a Gallery event with patients, practitioners, and policy-makers. This study provides a look at the complexities surrounding TB and emphasizes the need for holistic interventions for TB that address all aspects of the disease, including its social determinants. It also highlights the potential of Photovoice as an effective means to bring much-needed attention to this disease. © The Author (2013). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  20. Harnessing case isolation and ring vaccination to control Ebola.

    Directory of Open Access Journals (Sweden)

    Chad Wells

    2015-05-01

    Full Text Available As a devastating Ebola outbreak in West Africa continues, non-pharmaceutical control measures including contact tracing, quarantine, and case isolation are being implemented. In addition, public health agencies are scaling up efforts to test and deploy candidate vaccines. Given the experimental nature and limited initial supplies of vaccines, a mass vaccination campaign might not be feasible. However, ring vaccination of likely case contacts could provide an effective alternative in distributing the vaccine. To evaluate ring vaccination as a strategy for eliminating Ebola, we developed a pair approximation model of Ebola transmission, parameterized by confirmed incidence data from June 2014 to January 2015 in Liberia and Sierra Leone. Our results suggest that if a combined intervention of case isolation and ring vaccination had been initiated in the early fall of 2014, up to an additional 126 cases in Liberia and 560 cases in Sierra Leone could have been averted beyond case isolation alone. The marginal benefit of ring vaccination is predicted to be greatest in settings where there are more contacts per individual, greater clustering among individuals, when contact tracing has low efficacy or vaccination confers post-exposure protection. In such settings, ring vaccination can avert up to an additional 8% of Ebola cases. Accordingly, ring vaccination is predicted to offer a moderately beneficial supplement to ongoing non-pharmaceutical Ebola control efforts.

  1. Harnessing case isolation and ring vaccination to control Ebola.

    Science.gov (United States)

    Wells, Chad; Yamin, Dan; Ndeffo-Mbah, Martial L; Wenzel, Natasha; Gaffney, Stephen G; Townsend, Jeffrey P; Meyers, Lauren Ancel; Fallah, Mosoka; Nyenswah, Tolbert G; Altice, Frederick L; Atkins, Katherine E; Galvani, Alison P

    2015-05-01

    As a devastating Ebola outbreak in West Africa continues, non-pharmaceutical control measures including contact tracing, quarantine, and case isolation are being implemented. In addition, public health agencies are scaling up efforts to test and deploy candidate vaccines. Given the experimental nature and limited initial supplies of vaccines, a mass vaccination campaign might not be feasible. However, ring vaccination of likely case contacts could provide an effective alternative in distributing the vaccine. To evaluate ring vaccination as a strategy for eliminating Ebola, we developed a pair approximation model of Ebola transmission, parameterized by confirmed incidence data from June 2014 to January 2015 in Liberia and Sierra Leone. Our results suggest that if a combined intervention of case isolation and ring vaccination had been initiated in the early fall of 2014, up to an additional 126 cases in Liberia and 560 cases in Sierra Leone could have been averted beyond case isolation alone. The marginal benefit of ring vaccination is predicted to be greatest in settings where there are more contacts per individual, greater clustering among individuals, when contact tracing has low efficacy or vaccination confers post-exposure protection. In such settings, ring vaccination can avert up to an additional 8% of Ebola cases. Accordingly, ring vaccination is predicted to offer a moderately beneficial supplement to ongoing non-pharmaceutical Ebola control efforts.

  2. Heat shock proteins and cancer: How can nanomedicine be harnessed?

    Science.gov (United States)

    Sauvage, Félix; Messaoudi, Samir; Fattal, Elias; Barratt, Gillian; Vergnaud-Gauduchon, Juliette

    2017-02-28

    Heat shock protein (hsp90) is an interesting target for cancer therapy because it is involved in the folding and stabilization of numerous proteins, including many that contribute to the development of cancer. It is part of the chaperone machinery that includes other heat shock proteins (hsp70, hsp27, hsp40) and is mainly localized in the cytosol, although many analogues or isoforms can be found in mitochondrion, endoplasmic reticulum and the cell membrane. Many potential inhibitors of hsp90 have been tested for cancer therapy but their usefulness is limited by their poor solubility in water and their ability to reach the target cells and the correct intracellular compartment. Nanomedicine, the incorporation of active molecules into an appropriate delivery system, could provide a solution to these drawbacks. In this review, we explain the rationale for using nanomedicine for this sort of cancer therapy, considering the properties of the chaperone machinery and of the different hsp90 analogues. We present some results that have already been obtained and put forward some strategies for delivery of hsp90 analogues to specific organelles. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Operational stability prediction in milling based on impact tests

    Science.gov (United States)

    Kiss, Adam K.; Hajdu, David; Bachrathy, Daniel; Stepan, Gabor

    2018-03-01

    Chatter detection is usually based on the analysis of measured signals captured during cutting processes. These techniques, however, often give ambiguous results close to the stability boundaries, which is a major limitation in industrial applications. In this paper, an experimental chatter detection method is proposed based on the system's response for perturbations during the machining process, and no system parameter identification is required. The proposed method identifies the dominant characteristic multiplier of the periodic dynamical system that models the milling process. The variation of the modulus of the largest characteristic multiplier can also be monitored, the stability boundary can precisely be extrapolated, while the manufacturing parameters are still kept in the chatter-free region. The method is derived in details, and also verified experimentally in laboratory environment.

  4. Preclinical tests of an android based dietary logging application.

    Science.gov (United States)

    Kósa, István; Vassányi, István; Pintér, Balázs; Nemes, Márta; Kámánné, Krisztina; Kohut, László

    2014-01-01

    The paper describes the first, preclinical evaluation of a dietary logging application developed at the University of Pannonia, Hungary. The mobile user interface is briefly introduced. The three evaluation phases examined the completeness and contents of the dietary database and the time expenditure of the mobile based diet logging procedure. The results show that although there are substantial individual differences between various dietary databases, the expectable difference with respect to nutrient contents is below 10% on typical institutional menu list. Another important finding is that the time needed to record the meals can be reduced to about 3 minutes daily especially if the user uses set-based search. a well designed user interface on a mobile device is a viable and reliable way for a personalized lifestyle support service.

  5. The effect of spatial confinement on the noble-gas HArF molecule: structure and electric properties

    International Nuclear Information System (INIS)

    Kozłowska, Justyna; Bartkowiak, Wojciech

    2014-01-01

    Highlights: • The structure and electrical properties of HArF in spatial confinement are analyzed. • Orbital compression leads to decrease of bond lengths in the HArF molecule. • Spatial restriction causes a drop of the molecular (hyper)polarizabilities. • Spatial confinement reduces the electron correlation contribution to μ, α and β. - Abstract: A systematic study on the dipole moment and (hyper)polarizabilities of argon fluorohydride under spatial restriction was performed. Detailed analysis of the confinement induced changes in the structure of HArF is also presented. In order to render the influence of chemical compression on the properties in question a two-dimensional harmonic oscillator potential, mimicking a cylindrical confinement, was applied. Through the comparison of the results obtained for HArF with those of HF the effect of Ar insertion on the above properties was discussed. A hierarchy of ab initio methods including HF, MP2, CCSD and CCSD(T), has been employed to investigate the effect of orbital compression on the electron correlation contribution to the studied electric properties. It was observed that the external confining potential modifies the electronic contributions to the dipole moment and (hyper)polarizabilities of HArF. In particular, the first hyperpolarizability of HArF is remarkably smaller than that of the unconfined HArF molecule

  6. The effect of spatial confinement on the noble-gas HArF molecule: structure and electric properties

    Energy Technology Data Exchange (ETDEWEB)

    Kozłowska, Justyna; Bartkowiak, Wojciech, E-mail: wojciech.bartkowiak@pwr.edu.pl

    2014-09-30

    Highlights: • The structure and electrical properties of HArF in spatial confinement are analyzed. • Orbital compression leads to decrease of bond lengths in the HArF molecule. • Spatial restriction causes a drop of the molecular (hyper)polarizabilities. • Spatial confinement reduces the electron correlation contribution to μ, α and β. - Abstract: A systematic study on the dipole moment and (hyper)polarizabilities of argon fluorohydride under spatial restriction was performed. Detailed analysis of the confinement induced changes in the structure of HArF is also presented. In order to render the influence of chemical compression on the properties in question a two-dimensional harmonic oscillator potential, mimicking a cylindrical confinement, was applied. Through the comparison of the results obtained for HArF with those of HF the effect of Ar insertion on the above properties was discussed. A hierarchy of ab initio methods including HF, MP2, CCSD and CCSD(T), has been employed to investigate the effect of orbital compression on the electron correlation contribution to the studied electric properties. It was observed that the external confining potential modifies the electronic contributions to the dipole moment and (hyper)polarizabilities of HArF. In particular, the first hyperpolarizability of HArF is remarkably smaller than that of the unconfined HArF molecule.

  7. The predictive value of the sacral base pressure test in detecting specific types of sacroiliac dysfunction

    Science.gov (United States)

    Mitchell, Travis D.; Urli, Kristina E.; Breitenbach, Jacques; Yelverton, Chris

    2007-01-01

    Abstract Objective This study aimed to evaluate the validity of the sacral base pressure test in diagnosing sacroiliac joint dysfunction. It also determined the predictive powers of the test in determining which type of sacroiliac joint dysfunction was present. Methods This was a double-blind experimental study with 62 participants. The results from the sacral base pressure test were compared against a cluster of previously validated tests of sacroiliac joint dysfunction to determine its validity and predictive powers. The external rotation of the feet, occurring during the sacral base pressure test, was measured using a digital inclinometer. Results There was no statistically significant difference in the results of the sacral base pressure test between the types of sacroiliac joint dysfunction. In terms of the results of validity, the sacral base pressure test was useful in identifying positive values of sacroiliac joint dysfunction. It was fairly helpful in correctly diagnosing patients with negative test results; however, it had only a “slight” agreement with the diagnosis for κ interpretation. Conclusions In this study, the sacral base pressure test was not a valid test for determining the presence of sacroiliac joint dysfunction or the type of dysfunction present. Further research comparing the agreement of the sacral base pressure test or other sacroiliac joint dysfunction tests with a criterion standard of diagnosis is necessary. PMID:19674694

  8. QoS testing of service-based applications

    OpenAIRE

    Driss , Maha; Jamoussi , Yassine; Ben Ghézala , Henda Hajjami

    2008-01-01

    International audience; Web services (WSs) are becoming increasingly popular because of their potential in several application domains including e-Enterprise, e-Business, e-Government, and e-Science. Based on open XML standards, WS technology allows the construction of massively distributed and loosely coupled applications. A service composition mechanism should satisfy not only functional properties but also non-functional Quality of Service (QoS) ones. In this paper, we introduce a discrete...

  9. Life management of power plant based on structural damage testing

    Energy Technology Data Exchange (ETDEWEB)

    Tallermo, H.; Klevtsov, I. [Thermal Engineering Department of Tallinn Technical University, Tallinn (Estonia); Arras, V. [Eesti Energia, Tallinn (Estonia)

    1998-12-31

    Life management system is based on the valid nowadays in Estonian power plants regulation documentation. The system allows to estimate stress distribution in components, find computational assessment of cumulated creep damage, determine when and where it is necessary to cut off the particular number of microsamples or take replicas. Finally, the real metal condition may be assessed on the basis of metallographic specimen research and reasonable 3-R decision - run, repair, replacement - made on further component use. (orig.) 6 refs.

  10. Life management of power plant based on structural damage testing

    Energy Technology Data Exchange (ETDEWEB)

    Tallermo, H; Klevtsov, I [Thermal Engineering Department of Tallinn Technical University, Tallinn (Estonia); Arras, V [Eesti Energia, Tallinn (Estonia)

    1999-12-31

    Life management system is based on the valid nowadays in Estonian power plants regulation documentation. The system allows to estimate stress distribution in components, find computational assessment of cumulated creep damage, determine when and where it is necessary to cut off the particular number of microsamples or take replicas. Finally, the real metal condition may be assessed on the basis of metallographic specimen research and reasonable 3-R decision - run, repair, replacement - made on further component use. (orig.) 6 refs.

  11. Ground test of satellite constellation based quantum communication

    OpenAIRE

    Liao, Sheng-Kai; Yong, Hai-Lin; Liu, Chang; Shentu, Guo-Liang; Li, Dong-Dong; Lin, Jin; Dai, Hui; Zhao, Shuang-Qiang; Li, Bo; Guan, Jian-Yu; Chen, Wei; Gong, Yun-Hong; Li, Yang; Lin, Ze-Hong; Pan, Ge-Sheng

    2016-01-01

    Satellite based quantum communication has been proven as a feasible way to achieve global scale quantum communication network. Very recently, a low-Earth-orbit (LEO) satellite has been launched for this purpose. However, with a single satellite, it takes an inefficient 3-day period to provide the worldwide connectivity. On the other hand, similar to how the Iridium system functions in classic communication, satellite constellation (SC) composed of many quantum satellites, could provide global...

  12. Cancer and autoimmunity: Harnessing longitudinal cohorts to probe the link.

    Science.gov (United States)

    Egiziano, Giordano; Bernatsky, Sasha; Shah, Ami A

    2016-02-01

    In many autoimmune rheumatic diseases, there is an increased risk of cancer compared to the general population. While reasons for this increased risk have not been elucidated, it has been hypothesized that the link between cancer and autoimmunity may be bidirectional. For instance, chronic inflammation and damage from the rheumatic disease or its therapies may trigger malignant transformation; conversely, antitumor immune responses targeting cancers may become cross-reactive resulting in autoimmunity. In rare rheumatic diseases, longitudinal observational studies can play a critical role in studying these complex relationships, thereby enabling investigators to quantify the extent of cancer risk, identify unique clinical phenotypes associated with cancer, investigate the biological link between these conditions, and define optimal strategies for screening and treatment of the underlying cancer. In this review, we discuss recent data on cancer in the rheumatic diseases and suggest a research agenda to address several gaps in our current knowledge base. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Beyond bibliometrics harnessing multidimensional indicators of scholarly impact

    CERN Document Server

    Sugimoto, Cassidy R

    2014-01-01

    Bibliometrics has moved well beyond the mere tracking of bibliographic citations. The web enables new ways to measure scholarly productivity and impact, making available tools and data that can reveal patterns of intellectual activity and impact that were previously invisible: mentions, acknowledgments, endorsements, downloads, recommendations, blog posts, tweets. This book describes recent theoretical and practical advances in metrics-based research, examining a variety of alternative metrics -- or "altmetrics" -- while also considering the ethical and cultural consequences of relying on metrics to assess the quality of scholarship. Once the domain of information scientists and mathematicians, bibliometrics is now a fast-growing, multidisciplinary field that ranges from webometrics to scientometrics to influmetrics. The contributors to Beyond Bibliometrics discuss the changing environment of scholarly publishing, the effects of open access and Web 2.0 on genres of discourse, novel analytic methods, and the e...

  14. 12 CFR 652.100 - Audit of the risk-based capital stress test.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Audit of the risk-based capital stress test... AGRICULTURAL MORTGAGE CORPORATION FUNDING AND FISCAL AFFAIRS Risk-Based Capital Requirements § 652.100 Audit of the risk-based capital stress test. You must have a qualified, independent external auditor review...

  15. PHARMACOGENETIC TESTING OPPORTUNITIES IN CARDIOLOGY BASED ON EXOME SEQUENCING

    Directory of Open Access Journals (Sweden)

    N. V. Shcherbakova

    2014-01-01

    Full Text Available Aim. To study what cardiac drugs currently have any comments on biomarkers and what information can be obtained by pharmacogenetic testing using data exome sequencing in patients with cardiac diseases.Material and methods. Exome sequencing in random participant of the ATEROGEN IVANOVO study and bioinformatics analysis of the data were performed. Point mutations were annotated using ANNOVAR program, as well as comparison with a number of specialized databases was done on the basis of user protocols.Results. 11 cardiac drugs and 7 genes which variants can influence cardiac drug metabolism were analyzed. According to exome sequencing of the participant we did not reveal allelic variants that require dose regime correction and careful efficacy control.Conclusion. The exome sequencing application is the next step to a wide range of personalized therapy. Future opportunities for improvement of the risk-benefit ratio in each patient are the main purpose of the collection and analysis of pharmacogenetic data.

  16. Pilot test and optimization of plasma based deNOx

    DEFF Research Database (Denmark)

    Stamate, Eugen; Chen, Weifeng; Michelsen, Poul

    . Experiments are in good agreement with numerical simulations. An optimized oxidation scheme for NOx reduction processes with time dependent combustion, such as the biomass power plants, was developed. Ozone production by micro-hollow and capillary discharges at atmospheric pressures was investigated......The NOx reduction of flue gas by plasma generated ozone was investigated in pilot test experiments at two industrial power plants running on natural gas (Ringsted) and biomass (Haslev). Reduction rates higher than 95% have been achieved for a molar ratio O3:NOx of 1.56. Fourier transform infrared...... and ultraviolet absorption spectroscopy were used for spatial measurements of stable molecules and radicals along the reduction reactor. Reactions of O3 injected in the flue gas in the reduction reactor were also modeled including the influence of the flue gas temperature, water droplets and SOx and HCl content...

  17. Lay perceptions of predictive testing for diabetes based on DNA test results versus family history assessment: a focus group study.

    Science.gov (United States)

    Wijdenes-Pijl, Miranda; Dondorp, Wybo J; Timmermans, Danielle Rm; Cornel, Martina C; Henneman, Lidewij

    2011-07-05

    This study assessed lay perceptions of issues related to predictive genetic testing for multifactorial diseases. These perceived issues may differ from the "classic" issues, e.g. autonomy, discrimination, and psychological harm that are considered important in predictive testing for monogenic disorders. In this study, type 2 diabetes was used as an example, and perceptions with regard to predictive testing based on DNA test results and family history assessment were compared. Eight focus group interviews were held with 45 individuals aged 35-70 years with (n = 3) and without (n = 1) a family history of diabetes, mixed groups of these two (n = 2), and diabetes patients (n = 2). All interviews were transcribed and analysed using Atlas-ti. Most participants believed in the ability of a predictive test to identify people at risk for diabetes and to motivate preventive behaviour. Different reasons underlying motivation were considered when comparing DNA test results and a family history risk assessment. A perceived drawback of DNA testing was that diabetes was considered not severe enough for this type of risk assessment. In addition, diabetes family history assessment was not considered useful by some participants, since there are also other risk factors involved, not everyone has a diabetes family history or knows their family history, and it might have a negative influence on family relations. Respect for autonomy of individuals was emphasized more with regard to DNA testing than family history assessment. Other issues such as psychological harm, discrimination, and privacy were only briefly mentioned for both tests. The results suggest that most participants believe a predictive genetic test could be used in the prevention of multifactorial disorders, such as diabetes, but indicate points to consider before both these tests are applied. These considerations differ with regard to the method of assessment (DNA test or obtaining family history) and also differ from

  18. Lay perceptions of predictive testing for diabetes based on DNA test results versus family history assessment: a focus group study

    Directory of Open Access Journals (Sweden)

    Cornel Martina C

    2011-07-01

    Full Text Available Abstract Background This study assessed lay perceptions of issues related to predictive genetic testing for multifactorial diseases. These perceived issues may differ from the "classic" issues, e.g. autonomy, discrimination, and psychological harm that are considered important in predictive testing for monogenic disorders. In this study, type 2 diabetes was used as an example, and perceptions with regard to predictive testing based on DNA test results and family history assessment were compared. Methods Eight focus group interviews were held with 45 individuals aged 35-70 years with (n = 3 and without (n = 1 a family history of diabetes, mixed groups of these two (n = 2, and diabetes patients (n = 2. All interviews were transcribed and analysed using Atlas-ti. Results Most participants believed in the ability of a predictive test to identify people at risk for diabetes and to motivate preventive behaviour. Different reasons underlying motivation were considered when comparing DNA test results and a family history risk assessment. A perceived drawback of DNA testing was that diabetes was considered not severe enough for this type of risk assessment. In addition, diabetes family history assessment was not considered useful by some participants, since there are also other risk factors involved, not everyone has a diabetes family history or knows their family history, and it might have a negative influence on family relations. Respect for autonomy of individuals was emphasized more with regard to DNA testing than family history assessment. Other issues such as psychological harm, discrimination, and privacy were only briefly mentioned for both tests. Conclusion The results suggest that most participants believe a predictive genetic test could be used in the prevention of multifactorial disorders, such as diabetes, but indicate points to consider before both these tests are applied. These considerations differ with regard to the method of assessment

  19. Simulation-Based Testing of Pager Interruptions During Laparoscopic Cholecystectomy.

    Science.gov (United States)

    Sujka, Joseph A; Safcsak, Karen; Bhullar, Indermeet S; Havron, William S

    2018-01-30

    To determine if pager interruptions affect operative time, safety, or complications and management of pager issues during a simulated laparoscopic cholecystectomy. Twelve surgery resident volunteers were tested on a Simbionix Lap Mentor II simulator. Each resident performed 6 randomized simulated laparoscopic cholecystectomies; 3 with pager interruptions (INT) and 3 without pager interruptions (NO-INT). The pager interruptions were sent in the form of standardized patient vignettes and timed to distract the resident during dissection of the critical view of safety and clipping of the cystic duct. The residents were graded on a pass/fail scale for eliciting appropriate patient history and management of the pager issue. Data was extracted from the simulator for the following endpoints: operative time, safety metrics, and incidence of operative complications. The Mann-Whitney U test and contingency table analysis were used to compare the 2 groups (INT vs. NO-INT). Level I trauma center; Simulation laboratory. Twelve general surgery residents. There was no significant difference between the 2 groups in any of the operative endpoints as measured by the simulator. However, in the INT group, only 25% of the time did the surgery residents both adequately address the issue and provide effective patient management in response to the pager interruption. Pager interruptions did not affect operative time, safety, or complications during the simulated procedure. However, there were significant failures in the appropriate evaluations and management of pager issues. Consideration for diversion of patient care issues to fellow residents not operating to improve quality and safety of patient care outside the operating room requires further study. Copyright © 2018. Published by Elsevier Inc.

  20. Test

    DEFF Research Database (Denmark)

    Bendixen, Carsten

    2014-01-01

    Bidrag med en kortfattet, introducerende, perspektiverende og begrebsafklarende fremstilling af begrebet test i det pædagogiske univers.......Bidrag med en kortfattet, introducerende, perspektiverende og begrebsafklarende fremstilling af begrebet test i det pædagogiske univers....

  1. NI Based System for Seu Testing of Memory Chips for Avionics

    Directory of Open Access Journals (Sweden)

    Boruzdina Anna

    2016-01-01

    Full Text Available This paper presents the results of implementation of National Instrument based system for Single Event Upset testing of memory chips into neutron generator experimental facility, which used for SEU tests for avionics purposes. Basic SEU testing algorithm with error correction and constant errors detection is presented. The issues of radiation shielding of NI based system are discussed and solved. The examples of experimental results show the applicability of the presented system for SEU memory testing under neutrons influence.

  2. Harnessing context sensing to develop a mobile intervention for depression.

    Science.gov (United States)

    Burns, Michelle Nicole; Begale, Mark; Duffecy, Jennifer; Gergle, Darren; Karr, Chris J; Giangrande, Emily; Mohr, David C

    2011-08-12

    Mobile phone sensors can be used to develop context-aware systems that automatically detect when patients require assistance. Mobile phones can also provide ecological momentary interventions that deliver tailored assistance during problematic situations. However, such approaches have not yet been used to treat major depressive disorder. The purpose of this study was to investigate the technical feasibility, functional reliability, and patient satisfaction with Mobilyze!, a mobile phone- and Internet-based intervention including ecological momentary intervention and context sensing. We developed a mobile phone application and supporting architecture, in which machine learning models (ie, learners) predicted patients' mood, emotions, cognitive/motivational states, activities, environmental context, and social context based on at least 38 concurrent phone sensor values (eg, global positioning system, ambient light, recent calls). The website included feedback graphs illustrating correlations between patients' self-reported states, as well as didactics and tools teaching patients behavioral activation concepts. Brief telephone calls and emails with a clinician were used to promote adherence. We enrolled 8 adults with major depressive disorder in a single-arm pilot study to receive Mobilyze! and complete clinical assessments for 8 weeks. Promising accuracy rates (60% to 91%) were achieved by learners predicting categorical contextual states (eg, location). For states rated on scales (eg, mood), predictive capability was poor. Participants were satisfied with the phone application and improved significantly on self-reported depressive symptoms (beta(week) = -.82, P depressive symptoms (beta(week) = -.81, P depressive disorder diagnosis (b(week) = -.65, P = .03, per-protocol remission rate = 85.71%). Comorbid anxiety symptoms also decreased (beta(week) = -.71, P depression, as well as one of the first attempts to use context sensing to identify mental health

  3. Harnessing the Collective Power of Eyewitnesses for Improved Earthquake Information

    Science.gov (United States)

    Bossu, R.; Lefebvre, S.; Mazet-Roux, G.; Steed, R.

    2013-12-01

    earthquakes within, as an average 90s of their occurrence, and can map, in certain cases, the damaged areas. Thanks to the flashsourced and crowdsourced information, we developed an innovative Twitter earthquake information service (currently under test and to be open by November) which intends to offer notifications for earthquakes that matter for the public only. It provides timely information for felt and damaging earthquakes regardless their magnitude and heads-up for seismologists. In conclusion, the experience developed at the EMSC demonstrates the benefit of involving eyewitnesses in earthquake surveillance. The data collected directly and indirectly from eyewitnesses complement information derived from monitoring networks and contribute to improved services. By increasing interaction between science and society, it opens new opportunities for raising awareness on seismic hazard.

  4. Harnessing Apoptotic Cell Clearance to Treat Autoimmune Arthritis

    Directory of Open Access Journals (Sweden)

    Philippe Saas

    2017-10-01

    Full Text Available Early-stage apoptotic cells possess immunomodulatory properties. Proper apoptotic cell clearance during homeostasis has been shown to limit subsequent immune responses. Based on these observations, early-stage apoptotic cell infusion has been used to prevent unwanted inflammatory responses in different experimental models of autoimmune diseases or transplantation. Moreover, this approach has been shown to be feasible without any toxicity in patients undergoing allogeneic hematopoietic cell transplantation to prevent graft-versus-host disease. However, whether early-stage apoptotic cell infusion can be used to treat ongoing inflammatory disorders has not been reported extensively. Recently, we have provided evidence that early-stage apoptotic cell infusion is able to control, at least transiently, ongoing collagen-induced arthritis. This beneficial therapeutic effect is associated with the modulation of antigen-presenting cell functions mainly of macrophages and plasmacytoid dendritic cells, as well as the induction of collagen-specific regulatory CD4+ T cells (Treg. Furthermore, the efficacy of this approach is not altered by the association with two standard treatments of rheumatoid arthritis (RA, methotrexate and tumor necrosis factor (TNF inhibition. Here, in the light of these observations and recent data of the literature, we discuss the mechanisms of early-stage apoptotic cell infusion and how this therapeutic approach can be transposed to patients with RA.

  5. Harnessing the potential of biomaterials for brain repair after stroke

    Science.gov (United States)

    Tuladhar, Anup; Payne, Samantha L.; Shoichet, Molly S.

    2018-03-01

    Stroke is a devastating disease for which no clinical treatment exists to regenerate lost tissue. Strategies for brain repair in animal models of stroke include the delivery of drug or cell-based therapeutics; however, the complex anatomy and functional organization of the brain presents many challenges. Biomaterials may alleviate some of these challenges by providing a scaffold, localizing the therapy to the site of action, and/or modulating cues to brain cells. Here, the challenges associated with delivery of therapeutics to the brain and the biomaterial strategies used to overcome these challenges are described. For example, innovative hydrogel delivery systems have been designed to provide sustained trophic factor delivery for endogenous repair and to support transplanted cell survival and integration. Novel treatments, such as electrical stimulation of transplanted cells and the delivery of factors for the direct reprogramming of astrocytes into neurons, may be further enhanced by biomaterial delivery systems. Ultimately, improved clinical translation will be achieved by combining clinically relevant therapies with biomaterials strategies.

  6. Research on engineering-oriented constraints conflict detection in collaborative design of wire harness technology

    Institute of Scientific and Technical Information of China (English)

    LIU Xiaoping; HE Honglin; XU Benzhu

    2012-01-01

    Engineering-oriented constraint of harness technology has much information and project information presents progressive changes along with the design. Therefore, how to handle conflict resolution quickly is a problem to be solved. Process model of con- flict detection is put forward according to characteristics of harness technology design engineering-oriented constraint, and then two problems of how to conduct conflict positioning and judgment of constraint rules are introduced in this paper. Afterwards in this pa- per, constraint information directed acyclic graph is established by classified project constraint information to solve the conflict posi- tioning problem; solution of constraint satisfaction problem is applied to realize judgment problem of constraint rules. Finally, exam- ple is used to analyze the method in this paper to further verify the correctness and effectiveness of this method.

  7. [Experimental research of gaits based on young plantar pressure test].

    Science.gov (United States)

    Meng, Qingyun; Tan, Shili; Yu, Hongliu; Shen, Lixing; Zhuang, Jianhai; Wang, Jinwu

    2014-10-01

    The present paper is to study the center line of the plantar pressure of normal young people, and to find the relation between center line of the plantar pressure and gait stability and balance. The paper gives the testing principle and calculating methods for geometric center of plantar pressure distribution and the center of pressure due to the techniques of footprint frame. The calculating formulas in both x direction and y direction are also deduced in the paper. In the experiments carried out in our laboratory, the gait parameters of 131 young subjects walking as usual speed were acquired, and 14 young subjects of the total were specially analyzed. We then provided reference data for the walking gait database of young people, including time parameters, space parameters and plantar pressure parameters. We also obtained the line of geometry center and pressure center under the foot. We found that the differences existed in normal people's geometric center line and the pressure center line. The center of pressure trajectory revealed foot movement stability. The length and lateral changes of the center line of the plantar pressure could be applied to analysis of the plantar pressure of all kinds of people. The results in this paper are useful in clinical foot disease diagnosis and evaluation of surgical effect.

  8. Test and Score Data Summary for TOEFL[R] Internet-Based and Paper-Based Tests. January 2008-December 2008 Test Data

    Science.gov (United States)

    Educational Testing Service, 2008

    2008-01-01

    The Test of English as a Foreign Language[TM], better known as TOEFL[R], is designed to measure the English-language proficiency of people whose native language is not English. TOEFL scores are accepted by more than 6,000 colleges, universities, and licensing agencies in 130 countries. The test is also used by governments, and scholarship and…

  9. Mood As Cumulative Expectation Mismatch: A Test of Theory Based on Data from Non-verbal Cognitive Bias Tests

    Directory of Open Access Journals (Sweden)

    Camille M. C. Raoult

    2017-12-01

    Full Text Available Affective states are known to influence behavior and cognitive processes. To assess mood (moderately long-term affective states, the cognitive judgment bias test was developed and has been widely used in various animal species. However, little is known about how mood changes, how mood can be experimentally manipulated, and how mood then feeds back into cognitive judgment. A recent theory argues that mood reflects the cumulative impact of differences between obtained outcomes and expectations. Here expectations refer to an established context. Situations in which an established context fails to match an outcome are then perceived as mismatches of expectation and outcome. We take advantage of the large number of studies published on non-verbal cognitive bias tests in recent years (95 studies with a total of 162 independent tests to test whether cumulative mismatch could indeed have led to the observed mood changes. Based on a criteria list, we assessed whether mismatch had occurred with the experimental procedure used to induce mood (mood induction mismatch, or in the context of the non-verbal cognitive bias procedure (testing mismatch. For the mood induction mismatch, we scored the mismatch between the subjects’ potential expectations and the manipulations conducted for inducing mood whereas, for the testing mismatch, we scored mismatches that may have occurred during the actual testing. We then investigated whether these two types of mismatch can predict the actual outcome of the cognitive bias study. The present evaluation shows that mood induction mismatch cannot well predict the success of a cognitive bias test. On the other hand, testing mismatch can modulate or even inverse the expected outcome. We think, cognitive bias studies should more specifically aim at creating expectation mismatch while inducing mood states to test the cumulative mismatch theory more properly. Furthermore, testing mismatch should be avoided as much as possible

  10. Har forhold under svangerskapet betydning for utviklingen av otitis media?

    Directory of Open Access Journals (Sweden)

    Kari J. Kværner

    2009-10-01

    Full Text Available  SAMMENDRAGMed utgangspunkt i data fra et populasjonsbasert utvalg av 7 992 norske tvillinger ble sammenhengenmellom gjentatte ørebetennelser og forhold under svangerskapet studert. Som parametre på intrauterinevekstforhold ble informasjon om fødselsvekt og gestasjonsalder fra Medisinsk Fødselsregister benyttet.Informasjon om rapporterte øreinfeksjoner ble basert på spørreskjemaer som ble besvart av tvillingene ialderen 18–25 år. Først studerte vi individuelle effekter av fødselsvekt og gestasjonsalder på forekomsten avotitis media (OM. Rapportert fødselsvekt hos individer med OM var signifikant lavere enn hos kontrollene,med en gjennomsnittsforskjell på 86 gram. Hos de som rapporterte OM var gjennomsnittlig gestasjonsalder3 dager kortere enn i kontrollmaterialet. Deretter beregnet vi effekten av fødselsvekt ved bruk av co-twinkontroll metoden. Blant monozygote (MZ tvillingpar gjenspeiler fødselsvektforskjeller innenfor tvillingparetintra-uterine miljøforskjeller. Blant dizygote (DZ par kan vektforskjellen være både genetiske ogmiljøbetinget. Ved sammenligning av fødselsvektforskjeller innenfor tvillingparene er tvillingen som ikkehar gjentatte øreinfeksjoner en matchet kontroll blant OM diskordante par. Resultatene antyder at lavfødselsvekt er en risikofaktor for otitis media. Gjennomsnittlig vektforskjell blant par diskordante for OMvar 48 gram, og den av tvillingen som ikke rapporterte OM hadde signifikant høyere fødselsvekt.Kværner KJ, Tambs K, Harris J, Magnus P. Do pregnancy-related factors influence the development ofotitis media? Nor J Epidemiol 1997; 7 (1: 55-58.  ENGLISH SUMMARYThe association between intrauterine growth, as measured by weight and gestational age, and the occurrenceof recurrent ear infections was studied using data from a population based sample of 7992 Norwegian twins.Perinatal measures were collected from the Medical Birth Registry, and reports of recurrent ear infectionswere based on

  11. Harnessing Private-Sector Innovation to Improve Health Insurance Exchanges.

    Science.gov (United States)

    Gresenz, Carole Roan; Hoch, Emily; Eibner, Christine; Rudin, Robert S; Mattke, Soeren

    2016-05-09

    Overhauling the individual health insurance market-including through the creation of health insurance exchanges-was a key component of the Patient Protection and Affordable Care Act's multidimensional approach to addressing the long-standing problem of the uninsured in the United States. Despite succeeding in enrolling millions of Americans, the exchanges still face several challenges, including poor consumer experience, high operational and development costs, and incomplete market penetration. In light of these challenges, analysts considered a different model for the exchanges-privately facilitated exchanges-which could address these challenges and deepen the Affordable Care Act's impact. In this model, the government retains control over sovereign exchange functions but allows the private sector to assume responsibility for more-peripheral exchange functions, such as developing and sustaining exchange websites. Although private-sector entities have already undertaken exchange-related functions on a limited basis, privately facilitated exchanges could conceivably relieve the government of its responsibility for front-end website operations and consumer decision-support functions entirely. A shift to privately facilitated exchanges could improve the consumer experience, increase enrollment, and lower costs for state and federal governments. A move to such a model requires, nonetheless, managing its risks, such as reduced consumer protection, increased consumer confusion, and the possible lack of a viable revenue base for privately facilitated exchanges, especially in less populous states. On net, the benefits are large enough and the risks sufficiently manageable to seriously consider such a shift. This paper provides background information and more detail on the analysts' assessment.

  12. Harnessing Data Flow and Modelling Potentials for Sustainable Development

    Directory of Open Access Journals (Sweden)

    Kassim S Mwitondi

    2012-12-01

    Full Text Available Tackling the global challenges relating to health, poverty, business, and the environment is heavily dependent on the flow and utilisation of data. However, while enhancements in data generation, storage, modelling, dissemination, and the related integration of global economies and societies are fast transforming the way we live and interact, the resulting dynamic, globalised, information society remains digitally divided. On the African continent in particular, this division has resulted in a gap between the knowledge generation and its transformation into tangible products and services. This paper proposes some fundamental approaches for a sustainable transformation of data into knowledge for the purpose of improving the people's quality of life. Its main strategy is based on a generic data sharing model providing access to data utilising and generating entities in a multi-disciplinary environment. It highlights the great potentials in using unsupervised and supervised modelling in tackling the typically predictive-in-nature challenges we face. Using both simulated and real data, the paper demonstrates how some of the key parameters may be generated and embedded in models to enhance their predictive power and reliability. The paper's conclusions include a proposed implementation framework setting the scene for the creation of decision support systems capable of addressing the key issues in society. It is expected that a sustainable data flow will forge synergies among the private sector, academic, and research institutions within and among countries. It is also expected that the paper's findings will help in the design and development of knowledge extraction from data in the wake of cloud computing and, hence, contribute towards the improvement in the people's overall quality of life. To avoid running high implementation costs, selected open source tools are recommended for developing and sustaining the system.

  13. Designing and testing a laser-based vibratory sensor

    Science.gov (United States)

    Nath, G.

    2018-04-01

    Sensor technology has proved its importance, not only in the range of few-meter applications in different fields, but in micro, nano, atomic and sub-atomic-sized objects. The present work describes the designing of a laser-based vibratory sensor using a He-Ne laser as the signal source. The received characteristics of the signal are mainly the frequency and amplitude of the vibration from which the physical parameters such as energy, power and absorption coefficients of the material are determined, which enables us to provide information of the hidden target or object. This laboratory-designed sensor finds application in different local phenomena as well as laboratory practical activity for students.

  14. A Comparative Study of Harnessing Cattle - An Important Chapter in the History of European Ethnology

    Czech Academy of Sciences Publication Activity Database

    Woitsch, Jiří

    2017-01-01

    Roč. 38, č. 2017 (2017), s. 59-89 ISSN 1335-4116 R&D Projects: GA ČR GA15-03754S Institutional support: RVO:68378076 Keywords : harnessing cattle * European ethnology * history of ethnology Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  15. The relevance of netnography to the harness of Romanian health care electronic word-of-mouth.

    Science.gov (United States)

    Bratucu, R; Gheorghe, I R; Radu, A; Purcarea, V L

    2014-09-15

    Nowadays, consumers use the computer mediated communication to make purchase decisions on a large variety of products and services. Since health care services are archetypal by nature, consumers in this field are one of the most encountered users of electronic word-of-mouth. The objective of this paper is to explain and support the necessity of adopting a different qualitative method when electronic word of mouth is harnessed on health care dedicated forums, that is, netnography.

  16. A novel approach for harnessing biofilm communities in moving bed biofilm reactors for industrial wastewater treatment

    OpenAIRE

    Joe A. Lemire; Marc A. Demeter; Iain George; Howard Ceri; Raymond J. Turner

    2015-01-01

    Moving bed biofilm reactors (MBBRs) are an effective biotechnology for treating industrial wastewater. Biomass retention on moving bed biofilm reactor (MBBR) carriers (biofilm support materials), allows for the ease-of-operation and high treatment capacity of MBBR systems. Optimization of MBBR systems has largely focused on aspects of carrier design, while little attention has been paid to enhancing strategies for harnessing microbial biomass. Previously, our research group demonstrated that ...

  17. Følelser, fiktion – og Facebook - har erobret den politiske arena

    DEFF Research Database (Denmark)

    Aagaard, Peter

    2016-01-01

    Er der ét træk de nye politiske bevægelser – fra Trump til Alternativet – har til fælles, er det evnen til at fortælle historier, vælgerne kan koble sig på som medfortællere. Historier om håb og frelse, fornedrelse og fortabelse. Det bringer drømmene og magien tilbage i politik. Derfor vinder de ...

  18. Failed Pavlik harness treatment for DDH as a risk factor for avascular necrosis.

    Science.gov (United States)

    Tiruveedhula, Madhu; Reading, Isabel C; Clarke, Nicholas M P

    2015-03-01

    Avascular necrosis (AVN) of the femoral head is an irreversible complication seen in the treatment of developmental dysplasia of hip (DDH) with the Pavlik harness. Its incidence is reported to be low after successful reduction of the hip but high if the hip is not concentrically relocated. We aim to investigate its incidence after failed Pavlik harness treatment. We prospectively followed up a group of children who failed Pavlik harness treatment for DDH treated at our institution by the senior author between 1988 and 2001 and compared their rates of AVN with a group of children who presented late and hence were treated surgically. AVN was graded as described by Kalamchi and MacEwen and only grade 2 to 4 AVN was considered significant and included in the analysis. Thirty-seven hips were included in the failed Pavlik group (group 1) and 86 hips in the no Pavlik group (group 2). Ten hips in group 1 developed AVN (27%), whereas only 7 hips in group 2 (8%) developed AVN; the odds of developing AVN after failed Pavlik treatment was 4.7 (95% confidence interval, 1.3-14.1) (P=0.009) with a relative risk of 3.32 (range, 1.37 to 8.05). There was no statistically significant association observed with duration of splintage and severity of AVN (Spearman's correlation, -0.46; P=0.18). However, there was a positive correlation noted with age at presentation and severity of AVN. Therefore, we advise close monitoring of hips in the Pavlik harness and discontinue its use if the hips are not reduced within 3 weeks. Level III.

  19. Hvorfor har vi lønforskelle mellem kvinder og mænd?

    DEFF Research Database (Denmark)

    Deding, Mette; Holt, Helle

    De seneste 10 år har den gennemsnitlige lønforskel mellem kvinder og mænd ligget på ca. 20 pct. I denne antologi stiller SFI skarpt på lønforskellene mellem kvinder og mænd og på de bagvedliggende årsager. Antologien er skrevet af en række fagpersoner, der alle bidrager med en specifik vinkel på ...

  20. Empirical usability testing in a component-based environment : improving test efficiency with component-specific usability measures

    NARCIS (Netherlands)

    Brinkman, W.P.; Haakma, R.; Bouwhuis, D.G.; Bastide, R.; Palanque, P.; Roth, J.

    2005-01-01

    This paper addresses the issue of usability testing in a component-based software engineering environment, specifically measuring the usability of different versions of a component in a more powerful manner than other, more holistic, usability methods. Three component-specific usability measures are

  1. Test marketing for value-added root and tuber based products in ...

    African Journals Online (AJOL)

    Test marketing for value-added root and tuber based products in Ikwuano local government area ... JE Ewuziem, C Aniedu, E Oti, VO Onyenobi ... root and tuber based products, developed at National Root Crops Research Institute, Umudike.

  2. Do sediment type and test durations affect results of laboratory-based, accelerated testing studies of permeable pavement clogging?

    Science.gov (United States)

    Nichols, Peter W B; White, Richard; Lucke, Terry

    2015-04-01

    Previous studies have attempted to quantify the clogging processes of Permeable Interlocking Concrete Pavers (PICPs) using accelerated testing methods. However, the results have been variable. This study investigated the effects that three different sediment types (natural and silica), and different simulated rainfall intensities, and testing durations had on the observed clogging processes (and measured surface infiltration rates) of laboratory-based, accelerated PICP testing studies. Results showed that accelerated simulated laboratory testing results are highly dependent on the type, and size of sediment used in the experiments. For example, when using real stormwater sediment up to 1.18 mm in size, the results showed that neither testing duration, nor stormwater application rate had any significant effect on PICP clogging. However, the study clearly showed that shorter testing durations generally increased clogging and reduced the surface infiltration rates of the models when artificial silica sediment was used. Longer testing durations also generally increased clogging of the models when using fine sediment (<300 μm). Results from this study will help researchers and designers better anticipate when and why PICPs are susceptible to clogging, reduce maintenance and extend the useful life of these increasingly common stormwater best management practices. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. Design of a testing strategy using non-animal based test methods: lessons learnt from the ACuteTox project.

    Science.gov (United States)

    Kopp-Schneider, Annette; Prieto, Pilar; Kinsner-Ovaskainen, Agnieszka; Stanzel, Sven

    2013-06-01

    In the framework of toxicology, a testing strategy can be viewed as a series of steps which are taken to come to a final prediction about a characteristic of a compound under study. The testing strategy is performed as a single-step procedure, usually called a test battery, using simultaneously all information collected on different endpoints, or as tiered approach in which a decision tree is followed. Design of a testing strategy involves statistical considerations, such as the development of a statistical prediction model. During the EU FP6 ACuteTox project, several prediction models were proposed on the basis of statistical classification algorithms which we illustrate here. The final choice of testing strategies was not based on statistical considerations alone. However, without thorough statistical evaluations a testing strategy cannot be identified. We present here a number of observations made from the statistical viewpoint which relate to the development of testing strategies. The points we make were derived from problems we had to deal with during the evaluation of this large research project. A central issue during the development of a prediction model is the danger of overfitting. Procedures are presented to deal with this challenge. Copyright © 2012 Elsevier Ltd. All rights reserved.

  4. Gene-based testing of interactions in association studies of quantitative traits.

    Directory of Open Access Journals (Sweden)

    Li Ma

    Full Text Available Various methods have been developed for identifying gene-gene interactions in genome-wide association studies (GWAS. However, most methods focus on individual markers as the testing unit, and the large number of such tests drastically erodes statistical power. In this study, we propose novel interaction tests of quantitative traits that are gene-based and that confer advantage in both statistical power and biological interpretation. The framework of gene-based gene-gene interaction (GGG tests combine marker-based interaction tests between all pairs of markers in two genes to produce a gene-level test for interaction between the two. The tests are based on an analytical formula we derive for the correlation between marker-based interaction tests due to linkage disequilibrium. We propose four GGG tests that extend the following P value combining methods: minimum P value, extended Simes procedure, truncated tail strength, and truncated P value product. Extensive simulations point to correct type I error rates of all tests and show that the two truncated tests are more powerful than the other tests in cases of markers involved in the underlying interaction not being directly genotyped and in cases of multiple underlying interactions. We applied our tests to pairs of genes that exhibit a protein-protein interaction to test for gene-level interactions underlying lipid levels using genotype data from the Atherosclerosis Risk in Communities study. We identified five novel interactions that are not evident from marker-based interaction testing and successfully replicated one of these interactions, between SMAD3 and NEDD9, in an independent sample from the Multi-Ethnic Study of Atherosclerosis. We conclude that our GGG tests show improved power to identify gene-level interactions in existing, as well as emerging, association studies.

  5. Research of web application based on B/S structure testing

    International Nuclear Information System (INIS)

    Ou Ge; Zhang Hongmei; Song Liming

    2007-01-01

    Software testing is very important method used to assure the quality of Web application. With the fast development of Web application, the old testing techniques can not satisfied the require any more. Because of this people begin to classify different part of the application, find out the content that can be tested by the test tools and studies the structure of testing to enhance his efficiency. This paper analyses the testing based on the feature of Web application, sums up the testing method and gives some improvements of them. (authors)

  6. OOK power model based dynamic error testing for smart electricity meter

    International Nuclear Information System (INIS)

    Wang, Xuewei; Chen, Jingxia; Jia, Xiaolu; Zhu, Meng; Yuan, Ruiming; Jiang, Zhenyu

    2017-01-01

    This paper formulates the dynamic error testing problem for a smart meter, with consideration and investigation of both the testing signal and the dynamic error testing method. To solve the dynamic error testing problems, the paper establishes an on-off-keying (OOK) testing dynamic current model and an OOK testing dynamic load energy (TDLE) model. Then two types of TDLE sequences and three modes of OOK testing dynamic power are proposed. In addition, a novel algorithm, which helps to solve the problem of dynamic electric energy measurement’s traceability, is derived for dynamic errors. Based on the above researches, OOK TDLE sequence generation equipment is developed and a dynamic error testing system is constructed. Using the testing system, five kinds of meters were tested in the three dynamic power modes. The test results show that the dynamic error is closely related to dynamic power mode and the measurement uncertainty is 0.38%. (paper)

  7. OOK power model based dynamic error testing for smart electricity meter

    Science.gov (United States)

    Wang, Xuewei; Chen, Jingxia; Yuan, Ruiming; Jia, Xiaolu; Zhu, Meng; Jiang, Zhenyu

    2017-02-01

    This paper formulates the dynamic error testing problem for a smart meter, with consideration and investigation of both the testing signal and the dynamic error testing method. To solve the dynamic error testing problems, the paper establishes an on-off-keying (OOK) testing dynamic current model and an OOK testing dynamic load energy (TDLE) model. Then two types of TDLE sequences and three modes of OOK testing dynamic power are proposed. In addition, a novel algorithm, which helps to solve the problem of dynamic electric energy measurement’s traceability, is derived for dynamic errors. Based on the above researches, OOK TDLE sequence generation equipment is developed and a dynamic error testing system is constructed. Using the testing system, five kinds of meters were tested in the three dynamic power modes. The test results show that the dynamic error is closely related to dynamic power mode and the measurement uncertainty is 0.38%.

  8. A method to harness global crowd-sourced data to understand travel behavior in avalanche terrain.

    Science.gov (United States)

    Hendrikx, J.; Johnson, J.

    2015-12-01

    To date, most studies of the human dimensions of decision making in avalanche terrain has focused on two areas - post-accident analysis using accident reports/interviews and, the development of tools as decision forcing aids. We present an alternate method using crowd-sourced citizen science, for understanding decision-making in avalanche terrain. Our project combines real-time GPS tracking via a smartphone application, with internet based surveys of winter backcountry users as a method to describe and quantify travel practices in concert with group decision-making dynamics, and demographic data of participants during excursions. Effectively, we use the recorded GPS track taken within the landscape as an expression of the decision making processes and terrain usage by the group. Preliminary data analysis shows that individual experience levels, gender, avalanche hazard, and group composition all influence the ways in which people travel in avalanche terrain. Our results provide the first analysis of coupled real-time GPS tracking of the crowd while moving in avalanche terrain combined with psychographic and demographic correlates. This research will lead to an improved understanding of real-time decision making in avalanche terrain. In this paper we will specifically focus on the presentation of the methods used to solicit, and then harness the crowd to obtain data in a unique and innovative application of citizen science where the movements within the terrain are the desired output data (Figure 1). Figure 1: Example GPS tracks sourced from backcountry winter users in the Teton Pass area (Wyoming), from the 2014-15 winter season, where tracks in red represent those recorded as self-assessed experts (as per our survey), and where tracks in blue represent those recorded as self-assessed intermediates. All tracks shown were obtained under similar avalanche conditions. Statistical analysis of terrain metrics showed that the experts used steeper terrain than the

  9. Harnessing the power of mobile technologies for collaborating, crowdsourcing, and creating

    Science.gov (United States)

    Crompton, H.

    2015-12-01

    Today's digital technologies can have a powerful influence on teaching and learning. M-learning and u-learning in particular are changing pedagogical practice. Sub categories are rapidly emerging, such as context-aware ubiquitous learning, that involve students learning subject content while immersed in authentic and relevant surroundings. Learning cultures are a nebulous blend of traditions, values, beliefs, and rituals built up over time. For a long time, education has long been conceived as classroom-based and predominantly sedentary (Merchant, 2012). Recent mobile technologies are disrupting this culture in favor of learning that is contextualized, personalized, on demand, and ubiquitous (Crompton, 2013). 21st century students are a different breed than past generations (Prensky, 2001). These students have grown up in a time that has not only altered their perceptions and practices but modified the wiring of the brain through neuroplasticity (Crompton, 2012). Students now cognitively receive information quickly through non-linear methods (Gross, 2003, Oblinger & Oblinger, 2005). They think differently. They also seem to be attached to mobile devices 24/7, although the content of the lesson does not match what they seem to be doing on the mobile devices. This presentation will showcase how to get your students to harness the power of mobile devices for educational purposes. For example, students in your classes will be using devices to collaborate on activities with Google Forms, crowdsourcing the best class questions in Slido, and screencasting thoughts and ideas to share with others with Educreations. These are examples of free apps or Web 2.0 tools that can be used on all the major mobile platforms. Crompton, H. (2013). Mobile learning: New approach, new theory. In Z. L. Berge & L. Y. Muilenburg (Eds.), Handbook of mobile learning (pp. 47-57). Prensky, M. (2001). Digital natives, digital immigrants. Mcb University Press, 9(5). Oblinger, D., & Oblinger, J

  10. Technical note: A simple back-mounted harness for grazing dairy cows to facilitate the sulfur hexafluoride tracer gas technique.

    Science.gov (United States)

    van Wyngaard, Josef D V; Meeske, Robin; Erasmus, Lourens J

    2018-03-01

    We describe here a cattle harness to attach a gas collection vessel to facilitate the sulfur hexafluoride (SF 6 ) tracer gas technique. The harness consists of 2 major components: (1) a lightweight, robust body fabricated from an equine surcingle or lunge roller with padded thoracic trapezius pressure points, a bespoke shaping shaft for spine support, and adjustable buckles on both sides; and (2) an elastic flank-strap to prevent the harness from dislodging. The spine support consists of stainless steel laminated with carbon fiber. This support minimizes the contact area with the animal's skin, relieves the spine area of pressure, and creates free flow of ambient air below the platform, reducing sweat accumulation and hence preventing skin lesions. The harness weighs approximately 1.2 kg, allows for attachment of 2 gas collection vessels (animal and background sample), and is cost effective. Copyright © 2018 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  11. The Belem Framework for Action: Harnessing the Power and Potential of Adult Learning and Education for a Viable Future

    Science.gov (United States)

    Adult Learning, 2012

    2012-01-01

    This article presents the Belem Framework for Action. This framework focuses on harnessing the power and potential of adult learning and education for a viable future. This framework begins with a preamble on adult education and towards lifelong learning.

  12. Automatic Model-Based Generation of Parameterized Test Cases Using Data Abstraction

    NARCIS (Netherlands)

    Calamé, Jens R.; Ioustinova, Natalia; Romijn, J.M.T.; Smith, G.; van de Pol, Jan Cornelis

    2007-01-01

    Developing test suites is a costly and error-prone process. Model-based test generation tools facilitate this process by automatically generating test cases from system models. The applicability of these tools, however, depends on the size of the target systems. Here, we propose an approach to

  13. Using mobile and web-based computerized tests to evaluate university students

    NARCIS (Netherlands)

    Romero, C.; Ventura, S.; De Bra, P.M.E.

    2009-01-01

    Mobile learning and testing is emerging as a potential educational environment. In this article we evaluate the use of mobile devices for testing as compared to web-based assessment systems. We also describe an authoring tool to develop adaptable and adaptive computerized tests that can be executed

  14. A Review of Models for Computer-Based Testing. Research Report 2011-12

    Science.gov (United States)

    Luecht, Richard M.; Sireci, Stephen G.

    2011-01-01

    Over the past four decades, there has been incremental growth in computer-based testing (CBT) as a viable alternative to paper-and-pencil testing. However, the transition to CBT is neither easy nor inexpensive. As Drasgow, Luecht, and Bennett (2006) noted, many design engineering, test development, operations/logistics, and psychometric changes…

  15. Unit-based functional IDDT testing for aging degradation monitoring in a VLIW processor

    NARCIS (Netherlands)

    Zhao, Yong; Kerkhoff, Hans G.

    2015-01-01

    In this paper, functional unit-based IDDT testing has been applied for a 90nm VLIW processor to monitor its aging degradation. This technique can provide health data for reliability evaluation as used in e.g. prognostic software for lifetime prediction. The test-program development based on the

  16. T-UPPAAL: Online Model-based Testing of Real-Time Systems

    DEFF Research Database (Denmark)

    Mikucionis, Marius; Larsen, Kim Guldstrand; Nielsen, Brian

    2004-01-01

    The goal of testing is to gain confidence in a physical computer based system by means of executing it. More than one third of typical project resources is spent on testing embedded and real-time systems, but still it remains ad-hoc, based on heuristics, and error-prone. Therefore systematic...

  17. A multivariate family-based association test using generalized estimating equations : FBAT-GEE

    NARCIS (Netherlands)

    Lange, C; Silverman, SK; Xu, [No Value; Weiss, ST; Laird, NM

    In this paper we propose a multivariate extension of family-based association tests based on generalized estimating equations. The test can be applied to multiple phenotypes and to phenotypic data obtained in longitudinal studies without making any distributional assumptions for the phenotypic

  18. Design of a sentence identification test with pictures (TIS-F based on the pediatric speech intelligibility test

    Directory of Open Access Journals (Sweden)

    Fernanda Freitas Vellozo

    Full Text Available ABSTRACT Purposes: to design a sentence identification test with pictures for adults (Teste de Identificação de Sentenças com Figuras (TIS-F as an alternative for evaluation of auditory figure-background ability for verbal sounds, based on the Pediatric Speech Intelligibility Test and also for assessment of unskillful individuals who cannot accomplish other tests with higher levels of difficulty and greater demands. Methods: the Adobe Illustrator software was used and the image vectorization technique applied for figures creation. The sentences and the competitive message were audio-recorded in a sound treated room by a female announcer, using the software - REAPER - FM Digital Audio Workstation. Results: the TIS-F consisted of a 32 x 45 cm card, containing 10 figures, each one measuring 12 x 12 cm; one compact disc containing a track with the test calibration tone and seven test tracks, each one containing ten sentences and a competitive message and a specific protocol. Conclusion: the TIS-F is composed of a compact disc with dual-channel recording, with seven tracks containing ten sentences and the competitive story, one card containing ten pictures and a labeling protocol for all presentations and S/N in use, as well as the established normality values.

  19. A test sheet generating algorithm based on intelligent genetic algorithm and hierarchical planning

    Science.gov (United States)

    Gu, Peipei; Niu, Zhendong; Chen, Xuting; Chen, Wei

    2013-03-01

    In recent years, computer-based testing has become an effective method to evaluate students' overall learning progress so that appropriate guiding strategies can be recommended. Research has been done to develop intelligent test assembling systems which can automatically generate test sheets based on given parameters of test items. A good multisubject test sheet depends on not only the quality of the test items but also the construction of the sheet. Effective and efficient construction of test sheets according to multiple subjects and criteria is a challenging problem. In this paper, a multi-subject test sheet generation problem is formulated and a test sheet generating approach based on intelligent genetic algorithm and hierarchical planning (GAHP) is proposed to tackle this problem. The proposed approach utilizes hierarchical planning to simplify the multi-subject testing problem and adopts genetic algorithm to process the layered criteria, enabling the construction of good test sheets according to multiple test item requirements. Experiments are conducted and the results show that the proposed approach is capable of effectively generating multi-subject test sheets that meet specified requirements and achieve good performance.

  20. The Estimation of Knowledge Solidity Based on the Comparative Analysis of Different Test Results

    Directory of Open Access Journals (Sweden)

    Y. K. Khenner

    2012-01-01

    Full Text Available At present, the testing techniques of knowledge estimation are widely spread in educational system. However, this method is seriously criticized including its application to the Unified State Examinations. The research is aimed at studying the limitations of testing techniques. The authors recommend a new way of knowledge solid- ity estimation bases on the comparative results analysis of various kinds of tests. While testing the large group of students, the authors found out that the results of the closed and open tests substantially differ. The comparative analysis demonstrates that the open tests assessment of the knowledge solidity is more adequate than that of the closed ones. As the research is only based on a single experiment, the authors recommend using this method further, substantiating the findings concerning the differences in tests results, and analyzing the advantages and disadvantages of the tests in question.