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Sample records for hardened rv development

  1. Studying of the function of expected ABC transporter Rv1458c-Rv1457c-Rv1456c in mycobacteria; Studium funkcie predpokladaneho ABC transportera Rv1458c-Rv1457c-Rv1456c v mykobakteriach

    Energy Technology Data Exchange (ETDEWEB)

    Sarkan, M; Mikusova, K; Kordulakova, J [Univerzita Komenskeho v Bratislave, Prirodovedecka fakulta, Katedra biochemie, 84215 Bratislava (Slovakia)

    2012-04-25

    The bacterium Mycobacterium tuberculosis - the originator of tuberculosis in humans - is characterized by a complex cell wall, which is responsible for a high bacteria resistant to adverse external environmental conditions, as well as to the common antibiotics. The structure of the cell wall components and enzymes involved into its biosynthesis are relatively well described, but there is no information on the transfer of intermediate products of its biosynthetic across the plasmatic membrane. Orthologues of genes rv1459c-rv1458c-rv1457c-rv1456c of M. tuberculosis are in the same configuration in genomes of all previously sequenced mycobacterial strains. Rv1459c gene encodes a probable glycosyltransferases and genes rv1458c, rv1457c rv1456c code nucleotide binding and transmembrane subunits of expected ABC transporter. In our work we focused on the study of the function of expected ABC transporter Rv1458c-Rv1457c-Rv1456c, through analysis of phenotypes of strains M. Smegmatis. They have orthologues of genes encoding the transmembrane subunits of this transporter suspended by fragment encoding resistance to kanamycin. (authors)

  2. Devising Strain Hardening Models Using Kocks–Mecking Plots—A Comparison of Model Development for Titanium Aluminides and Case Hardening Steel

    Directory of Open Access Journals (Sweden)

    Markus Bambach

    2016-08-01

    Full Text Available The present study focuses on the development of strain hardening models taking into account the peculiarities of titanium aluminides. In comparison to steels, whose behavior has been studied extensively in the past, titanium aluminides possess a much larger initial work hardening rate, a sharp peak stress and pronounced softening. The work hardening behavior of a TNB-V4 (Ti–44.5Al–6.25Nb–0.8Mo–0.1B alloy is studied using isothermal hot compression tests conducted on a Gleeble 3500 simulator, and compared to the typical case hardening steel 25MoCrS4. The behavior is analyzed with the help of the Kocks-Mecking plots. In contrast to steel the TNB-V4 alloy shows a non-linear course of θ (i.e., no stage-III hardening initially and exhibits neither a plateau (stage IV hardening nor an inflection point at all deformation conditions. The present paper describes the development and application of a methodology for the design of strain hardening models for the TNB-V4 alloy and the 25CrMoS4 steel by taking the course of the Kocks-Mecking plots into account. Both models use different approaches for the hardening and softening mechanisms and accurately predict the flow stress over a wide range of deformation conditions. The methodology may hence assist in further developments of more sophisticated physically-based strain hardening models for TiAl-alloys.

  3. Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of Mycobacterium tuberculosis in Individuals with Latent Tuberculosis Infection

    Directory of Open Access Journals (Sweden)

    Simon G. Kimuda

    2017-01-01

    Full Text Available Latent tuberculosis infection (LTBI is evidence of immunological control of tuberculosis. Dormancy survival regulator (DosR regulon-encoded proteins may have a role in the maintenance of LTBI. T cell responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins were found to be most frequent among household contacts of TB cases from Uganda compared to other DosR proteins, but antibody responses were not described. We characterized antibody responses to these proteins in individuals from Uganda. Antibodies to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins were measured in 68 uninfected individuals, 62 with LTBI, and 107 with active pulmonary tuberculosis (APTB cases. There were no differences in the concentrations of antibodies to Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins between individuals with LTBI and APTB and those who were uninfected. LTBI was associated with higher concentrations of antibodies to Rv1733c in female participants [adjusted geometric mean ratio: 1.812, 95% confidence interval (CI: 1.105 2.973, and p=0.019] but not in males (p value for interaction = 0.060. Antibodies to the four DosR regulon-encoded proteins investigated may not serve as good biomarkers of LTBI in the general population. More of the M.tb proteome needs to be screened to identify proteins that induce strong antibody responses in LTBI.

  4. Simultaneous surface engineering and bulk hardening of precipitation hardening stainless steel

    DEFF Research Database (Denmark)

    Frandsen, Rasmus Berg; Christiansen, Thomas; Somers, Marcel A. J.

    2006-01-01

    This article addresses simultaneous bulk precipitation hardening and low temperature surface engineering of two commercial precipitation hardening stainless steels: Sandvik Nanoflex® and Uddeholm Corrax®. Surface engineering comprised gaseous nitriding or gaseous carburising. Microstructural....... The duration and temperature of the nitriding/carburising surface hardening treatment can be chosen in agreement with the thermal treatment for obtaining optimal bulk hardness in the precipitation hardening stainless steel....... characterisation of the cases developed included X-ray diffraction analysis, reflected light microscopy and micro-hardness testing. It was found that the incorporation of nitrogen or carbon resulted in a hardened case consisting of a combination of (tetragonal) martensite and expanded (cubic) austenite...

  5. Radiation-hardened bulk CMOS technology

    International Nuclear Information System (INIS)

    Dawes, W.R. Jr.; Habing, D.H.

    1979-01-01

    The evolutionary development of a radiation-hardened bulk CMOS technology is reviewed. The metal gate hardened CMOS status is summarized, including both radiation and reliability data. The development of a radiation-hardened bulk silicon gate process which was successfully implemented to a commercial microprocessor family and applied to a new, radiation-hardened, LSI standard cell family is also discussed. The cell family is reviewed and preliminary characterization data is presented. Finally, a brief comparison of the various radiation-hardened technologies with regard to performance, reliability, and availability is made

  6. Recent developments in turning hardened steels - A review

    Science.gov (United States)

    Sivaraman, V.; Prakash, S.

    2017-05-01

    Hard materials ranging from HRC 45 - 68 such as hardened AISI H13, AISI 4340, AISI 52100, D2 STL, D3 STEEL Steel etc., need super hard tool materials to machine. Turning of these hard materials is termed as hard turning. Hard turning makes possible direct machining of the hard materials and also eliminates the lubricant requirement and thus favoring dry machining. Hard turning is a finish turning process and hence conventional grinding is not required. Development of the new advanced super hard tool materials such as ceramic inserts, Cubic Boron Nitride, Polycrystalline Cubic Boron Nitride etc. enabled the turning of these materials. PVD and CVD methods of coating have made easier the production of single and multi layered coated tool inserts. Coatings of TiN, TiAlN, TiC, Al2O3, AlCrN over cemented carbide inserts has lead to the machining of difficult to machine materials. Advancement in the process of hard machining paved way for better surface finish, long tool life, reduced tool wear, cutting force and cutting temperatures. Micro and Nano coated carbide inserts, nanocomposite coated PCBN inserts, micro and nano CBN coated carbide inserts and similar developments have made machining of hardened steels much easier and economical. In this paper, broad literature review on turning of hardened steels including optimizing process parameters, cooling requirements, different tool materials etc., are done.

  7. The development of remote controlled linear guide and mast vertical guide of repair robot for RV head CRDM nozzle region in NPP

    International Nuclear Information System (INIS)

    Kim, Seung Ho; Seo, Yong Chil; Shin, Ho Cheol; Lee, Sung Uk; Jung, Kyung Min

    2006-11-01

    Reactor vessel which is core instrument in NPP must maintains integrity in the high temperature, high pressure and high radiation environment. Therefore RV must be inspected periodically. If there is defect, the RV must be repaired. A remote controlled linear guide and a vertical guide were developed for a welding repair robot of the RV head CRDM nozzle region. During inspection/maintenance, the RV head is placed RV head storage which is a double circled concrete structure. A linear guide was developed to provide a linear motion to the repair robot, which locates the robot under the RV head. The linear guide also provides a strong support to the robot not to overturn when the robot repairs the RV head. The robot needs lifting about 2m to reach the CRDM nozzle, therefore a vertical guide was developed. For easy traveling, the linear guide is designed 4 parts and the vertical guide is designed 3 parts. A control system was developed to remotely control the guide system which is composed of a connecter box, cables, control box, a computer and a control program. A monitoring system was developed to monitor operation of the guide system

  8. The development of remote controlled linear guide and mast vertical guide of repair robot for RV head CRDM nozzle region in NPP

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seung Ho; Seo, Yong Chil; Shin, Ho Cheol; Lee, Sung Uk; Jung, Kyung Min

    2006-11-15

    Reactor vessel which is core instrument in NPP must maintains integrity in the high temperature, high pressure and high radiation environment. Therefore RV must be inspected periodically. If there is defect, the RV must be repaired. A remote controlled linear guide and a vertical guide were developed for a welding repair robot of the RV head CRDM nozzle region. During inspection/maintenance, the RV head is placed RV head storage which is a double circled concrete structure. A linear guide was developed to provide a linear motion to the repair robot, which locates the robot under the RV head. The linear guide also provides a strong support to the robot not to overturn when the robot repairs the RV head. The robot needs lifting about 2m to reach the CRDM nozzle, therefore a vertical guide was developed. For easy traveling, the linear guide is designed 4 parts and the vertical guide is designed 3 parts. A control system was developed to remotely control the guide system which is composed of a connecter box, cables, control box, a computer and a control program. A monitoring system was developed to monitor operation of the guide system.

  9. EMTP-RV at a glance

    Energy Technology Data Exchange (ETDEWEB)

    Mahseredjian, J.; Dennetiere, S. [IREQ Headquarters, PQ (Canada); Saad, O.; Khodabakhchian, B. [TransEnergie Technologies, PQ (Canada)

    2004-10-01

    A new restructured version of an electromagnetic transient program, EMTP-RV, which is a combination of the well-known EMTP and a powerful graphical interface EMTPWorks, is described. EMTP-RV provides a higher level of capabilities in the simulation of large scale electrical networks, making it possible to rapidly design, simulate and view large and complex systems, without the usual large expenditure of engineering and development time, and at the same time allowing more detailed studies on the complex phenomena of power system transients. EMTP-RV has a completely new control system solver, an optional Newton method for finding the simultaneous solution of all control system blocks, and a complex matrix-based steady-state solution, used primarily in automatic initialization of state-variables. The article also describes the highly efficient, intuitive and user-friendly graphical user interface EMTPWorks, which has an open architecture for maximized user configurability from basic user-defined model assemblies to more advanced script-based programming. The EMTP-RV package also includes an efficient data acquisition and processing software, named ScopeView and another visualization function called MPLOT. ScopeView offers multi-page and multi-column capabilities, an advanced built-in function editor, and is especially well adapted for the simultaneous viewing and mathematical post-processing of EMTP-RV. MPLOT, a compiled version of a set of m-files, is well suited for waveform viewing and statistical analysis. A one-week seminar and computer workshop on different aspects of transient system studies and analysis with EMTP-RV is provided twice a year by TransEnergie Technologies. 1 fig.

  10. DEVELOPMENT AND RESEARCH OF ULTRASONIC OSCILLATORY SYSTEM FOR HARDENING OF SPRING PLATE BILLETS

    Directory of Open Access Journals (Sweden)

    V. A. Tomilo

    2015-01-01

    Full Text Available Various schemes of ultrasonic oscillatory system are developed: with a «force nonsensitive» support, with a «force sensitive» support, with the deforming steel balls in bulk. Results of the ultrasonic treatment showed that hardening of a surface of the samples took place when the vibration amplitude of a radiator exceeds a certain level. The level of hardening increases with increase in amplitude of fluctuations of a radiator. Higher level of hardening is registered when the surface is treated by steel balls.

  11. Prevention of pneumonic plague in mice, rats, guinea pigs and non-human primates with clinical grade rV10, rV10-2 or F1-V vaccines

    Science.gov (United States)

    Quenee, Lauriane E.; Ciletti, Nancy A.; Elli, Derek; Hermanas, Timothy M.; Schneewind, Olaf

    2012-01-01

    Yersinia pestis causes plague, a disease with high mortality in humans that can be transmitted by fleabite or aerosol. A US Food and Drug Administration (FDA)-licensed plague vaccine is currently not available. Vaccine developers have focused on two subunits of Y. pestis: LcrV, a protein at the tip of type III secretion needles, and F1, the fraction 1 pilus antigen. F1-V, a hybrid generated via translational fusion of both antigens, is being developed for licensure as a plague vaccine. The rV10 vaccine is a non-toxigenic variant of LcrV lacking residues 271–300. Here we developed Current Good Manufacturing Practice (cGMP) protocols for rV10. Comparison of clinical grade rV10 with F1-V did not reveal significant differences in plague protection in mice, guinea pigs or cynomolgus macaques. We also developed cGMP protocols for rV10-2, a variant of rV10 with an altered affinity tag. Immunization with rV10-2 adsorbed to aluminum hydroxide elicited antibodies against LcrV and conferred pneumonic plague protection in mice, rats, guinea pigs, cynomolgus macaques and African Green monkeys. The data support further development of rV10-2 for FDA Investigational New Drug (IND) authorization review and clinical testing. PMID:21763383

  12. Hardening Azure applications

    CERN Document Server

    Gaurav, Suraj

    2015-01-01

    Learn what it takes to build large scale, mission critical applications -hardened applications- on the Azure cloud platform. This 208 page book covers the techniques and engineering principles that every architect and developer needs to know to harden their Azure/.NET applications to ensure maximum reliability and high availability when deployed at scale. While the techniques are implemented in .NET and optimized for Azure, the principles here will also be valuable for users of other cloud-based development platforms. Applications come in a variety of forms, from simple apps that can be bui

  13. Neutron energy spectrum influence on irradiation hardening and microstructural development of tungsten

    Energy Technology Data Exchange (ETDEWEB)

    Fukuda, Makoto, E-mail: makoto.fukuda@qse.tohoku.ac.jp [Tohoku University, Sendai, 980-8579 (Japan); Kiran Kumar, N.A.P.; Koyanagi, Takaaki; Garrison, Lauren M. [Oak Ridge National Laboratory, Oak Ridge, TN, 37831 (United States); Snead, Lance L. [Massachusetts Institute of Technology, Cambridge, MA, 02139 (United States); Katoh, Yutai [Oak Ridge National Laboratory, Oak Ridge, TN, 37831 (United States); Hasegawa, Akira [Tohoku University, Sendai, 980-8579 (Japan)

    2016-10-15

    Neutron irradiation to single crystal pure tungsten was performed in the mixed spectrum High Flux Isotope Reactor (HFIR). To investigate the influences of neutron energy spectrum, the microstructure and irradiation hardening were compared with previous data obtained from the irradiation campaigns in the mixed spectrum Japan Material Testing Reactor (JMTR) and the sodium-cooled fast reactor Joyo. The irradiation temperatures were in the range of ∼90–∼800 °C and fast neutron fluences were 0.02–9.00 × 10{sup 25} n/m{sup 2} (E > 0.1 MeV). Post irradiation evaluation included Vickers hardness measurements and transmission electron microscopy. The hardness and microstructure changes exhibited a clear dependence on the neutron energy spectrum. The hardness appeared to increase with increasing thermal neutron flux when fast fluence exceeds 1 × 10{sup 25} n/m{sup 2} (E > 0.1 MeV). Irradiation induced precipitates considered to be χ- and σ-phases were observed in samples irradiated to >1 × 10{sup 25} n/m{sup 2} (E > 0.1 MeV), which were pronounced at high dose and due to the very high thermal neutron flux of HFIR. Although the irradiation hardening mainly caused by defects clusters in a low dose regime, the transmutation-induced precipitation appeared to impose additional significant hardening of the tungsten. - Highlights: • The microstructure and irradiation hardening of single crystal pure W irradiated in HFIR was investigated. • The neutron energy spectrum influence was evaluated by comparing the HFIR results with previous work in Joyo and JMTR. • In the dose range up to ∼1 dpa, the neutron energy spectrum influence of irradiation hardening was not clear. • In the dose range above 1 dpa, the neutron energy influence on irradiation hardening and microstructural development was clearly observed. • The irradiation induced precipitates caused significant irradiation hardening of pure W irradiated in HFIR.

  14. RV-Typer: A Web Server for Typing of Rhinoviruses Using Alignment-Free Approach.

    Directory of Open Access Journals (Sweden)

    Pandurang S Kolekar

    Full Text Available Rhinoviruses (RV are increasingly being reported to cause mild to severe infections of respiratory tract in humans. RV are antigenically the most diverse species of the genus Enterovirus and family Picornaviridae. There are three species of RV (RV-A, -B and -C, with 80, 32 and 55 serotypes/types, respectively. Antigenic variation is the main limiting factor for development of a cross-protective vaccine against RV.Serotyping of Rhinoviruses is carried out using cross-neutralization assays in cell culture. However, these assays become laborious and time-consuming for the large number of strains. Alternatively, serotyping of RV is carried out by alignment-based phylogeny of both protein and nucleotide sequences of VP1. However, serotyping of RV based on alignment-based phylogeny is a multi-step process, which needs to be repeated every time a new isolate is sequenced. In view of the growing need for serotyping of RV, an alignment-free method based on "return time distribution" (RTD of amino acid residues in VP1 protein has been developed and implemented in the form of a web server titled RV-Typer. RV-Typer accepts nucleotide or protein sequences as an input and computes return times of di-peptides (k = 2 to assign serotypes. The RV-Typer performs with 100% sensitivity and specificity. It is significantly faster than alignment-based methods. The web server is available at http://bioinfo.net.in/RV-Typer/home.html.

  15. Development of Bake Hardening Effect by Plastic Deformation and Annealing Conditions

    Directory of Open Access Journals (Sweden)

    Kvačkaj, T.

    2006-01-01

    Full Text Available The paper deals with the classification of steel sheets for automotives industry on the basis of strength and structural characteristics. Experimental works were aimed to obtain the best possible strengthening parameters as well as work hardening and solid solution ferrite hardening, which are the result of thermal activation of interstitial carbon atoms during paint-baking of auto body. Hardening process coming from interstitial atoms is realized as two-step process. The first step is BH (bake hardening effect achieved by interaction of interstitial atoms with dislocations. The Cottrels atmosphere is obtained. The second step of BH effect is to produced the hardening from precipitation of the carbon atoms in e-carbides, or formation of Fe32C4 carbides. WH (work hardening effect is obtained as dislocation hardening from plastic deformations during sheet deep drawing. Experimental works were aimed at as to achieve such plastic material properties after cold rolling, annealing and skin-pass rolling, which would be able to classify the material ZStE220BH into the drawing categories at the level of DQ – DDQ. As resulting from the experimental results, the optimal treatment conditions for the maximal sum (WH+BH = 86 MPa are as follows: total cold rolling deformation ecold = 65 %, annealing temperature Tanneal. = 700 °C.

  16. Laser transformation hardening effect on hardening zone features and surface hardness of tool steel AISI D2

    Directory of Open Access Journals (Sweden)

    D. Lesyk

    2017-06-01

    Full Text Available The relationship of technological input regimes of the laser transformation hardening on change the hardening depth, hardening width, and hardening angle, as well as surface hardness of the tool steel AISI D2 using multifactor experiment with elements of the analysis of variance and regression equations was determined. The laser transformation hardening process implemented by controlling the heating temperature using Nd:YAG fiber laser with scanner, pyrometer and proportional-integral-differential controller. The linear and quadratic regression models are developed, as well as response surface to determine the effect of the heating temperature and feed rate of the treated surface on the energy density of the laser beam, hardening depths, hardening width, hardening angle, and surface hardness are designed. The main effect on the energy density of the laser beam has a velocity laser treatment, on the other hand, the main effect on the geometrical parameters of the laser hardened zone and surface hardness has temperature heating are shown. The optimum magnitudes of the heating temperature (1270 °C and feed rate of the treated surface (90 mm/min for laser transformation hardening of the tool steel AISI D2 using fiber laser with scanner were defined.

  17. Development of Test Method for Simple Shear and Prediction of Hardening Behavior Considering the Branchings Effect

    International Nuclear Information System (INIS)

    Kim, Dongwook; Bang, Sungsik; Kim, Minsoo; Lee, Hyungyil; Kim, Naksoo

    2013-01-01

    In this study we establish a process to predict hardening behavior considering the Branchings effect for zircaloy-4 sheets. When a metal is compressed after tension in forming, the yield strength decreases. For this reason, the Branchings effect should be considered in FE simulations of spring-back. We suggested a suitable specimen size and a method for determining the optimum tightening torque for simple shear tests. Shear stress-strain curves are obtained for five materials. We developed a method to convert the shear load-displacement curve to the effective stress-strain curve with Fea. We simulated the simple shear forward/reverse test using the combined isotropic/kinematic hardening model. We also investigated the change of the load-displacement curve by varying the hardening coefficients. We determined the hardening coefficients so that they follow the hardening behavior of zircaloy-4 in experiments

  18. Development of Test Method for Simple Shear and Prediction of Hardening Behavior Considering the Branchings Effect

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dongwook; Bang, Sungsik; Kim, Minsoo; Lee, Hyungyil; Kim, Naksoo [Sogang Univ., Seoul (Korea, Republic of)

    2013-10-15

    In this study we establish a process to predict hardening behavior considering the Branchings effect for zircaloy-4 sheets. When a metal is compressed after tension in forming, the yield strength decreases. For this reason, the Branchings effect should be considered in FE simulations of spring-back. We suggested a suitable specimen size and a method for determining the optimum tightening torque for simple shear tests. Shear stress-strain curves are obtained for five materials. We developed a method to convert the shear load-displacement curve to the effective stress-strain curve with Fea. We simulated the simple shear forward/reverse test using the combined isotropic/kinematic hardening model. We also investigated the change of the load-displacement curve by varying the hardening coefficients. We determined the hardening coefficients so that they follow the hardening behavior of zircaloy-4 in experiments.

  19. The development of radiation hardened robot for nuclear facility

    International Nuclear Information System (INIS)

    Kim, Seung Ho; Jung, Seung Ho; Kim, Byung Soo and others

    2000-04-01

    The work conducted in this stage covers development of core technology of tele-robot system including monitoring technique in high-level radioactive area, tele-sensing technology and radiation-hardened technology for the non-destructive tele-inspection system which monitors the primary coolant system during the normal operations of PHWR(Pressurized Heavy Water Reactor) NPPs and measures the decrease of bending part of feeder pipe during overall. Based on the developed core technology, the monitoring mobile robot system of the primary coolant system and the feeder pipe inspecting robot system are developed

  20. The development of radiation hardened robot for nuclear facility

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seung Ho; Jung, Seung Ho; Kim, Byung Soo and others

    2000-04-01

    The work conducted in this stage covers development of core technology of tele-robot system including monitoring technique in high-level radioactive area, tele-sensing technology and radiation-hardened technology for the non-destructive tele-inspection system which monitors the primary coolant system during the normal operations of PHWR(Pressurized Heavy Water Reactor) NPPs and measures the decrease of bending part of feeder pipe during overall. Based on the developed core technology, the monitoring mobile robot system of the primary coolant system and the feeder pipe inspecting robot system are developed.

  1. Development of Deterministic and Probabilistic Fracture Mechanics Analysis Code PROFAS-RV for Reactor Pressure Vessel - Progress of the Work

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jong Min; Lee, Bong Sang [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    In this study, a deterministic/probabilistic fracture mechanics analysis program for reactor pressure vessel, PROFAS-RV, is developed. This program can evaluate failure probability of RPV using recent radiation embrittlement model of 10CFR50.61a and stress intensity factor calculation method of RCC-MRx code as well as the required basic functions of PFM program. Applications of some new radiation embrittlement model, material database, calculation method of stress intensity factors, and others which can improve fracture mechanics assessment of RPV are introduced. The purpose of this study is to develop a probabilistic fracture mechanics (PFM) analysis program for RPV considering above modification and application of newly developed models and calculation methods. In this paper, it deals with the development progress of the PFM analysis program for RPV, PROFAS-RV. The PROFAS-RV is being tested with other codes, and it is expected to revise and upgrade by reflecting the latest model and calculation method continuously. These efforts can minimize the uncertainty of the integrity evaluation for the reactor pressure vessel.

  2. Infection with koala retrovirus subgroup B (KoRV-B), but not KoRV-A, is associated with chlamydial disease in free-ranging koalas (Phascolarctos cinereus).

    Science.gov (United States)

    Waugh, Courtney A; Hanger, Jonathan; Loader, Joanne; King, Andrew; Hobbs, Matthew; Johnson, Rebecca; Timms, Peter

    2017-03-09

    The virulence of chlamydial infection in wild koalas is highly variable between individuals. Some koalas can be infected (PCR positive) with Chlamydia for long periods but remain asymptomatic, whereas others develop clinical disease. Chlamydia in the koala has traditionally been studied without regard to coinfection with other pathogens, although koalas are usually subject to infection with koala retrovirus (KoRV). Retroviruses can be immunosuppressive, and there is evidence of an immunosuppressive effect of KoRV in vitro. Originally thought to be a single endogenous strain, a new, potentially more virulent exogenous variant (KoRV-B) was recently reported. We hypothesized that KoRV-B might significantly alter chlamydial disease outcomes in koalas, presumably via immunosuppression. By studying sub-groups of Chlamydia and KoRV infected koalas in the wild, we found that neither total KoRV load (either viraemia or proviral copies per genome), nor chlamydial infection level or strain type, was significantly associated with chlamydial disease risk. However, PCR positivity with KoRV-B was significantly associated with chlamydial disease in koalas (p = 0.02961). This represents an example of a recently evolved virus variant that may be predisposing its host (the koala) to overt clinical disease when co-infected with an otherwise asymptomatic bacterial pathogen (Chlamydia).

  3. Radiation hardening of integrated circuits technologies

    International Nuclear Information System (INIS)

    Auberton-Herve, A.J.; Leray, J.L.

    1991-01-01

    The radiation hardening studies started in the mid decade -1960-1970. To survive the different military or space radiative environment, a new engineering science borned, to understand the degradation of electronics components. The different solutions to improve the electronic behavior in such environment, have been named radiation hardening of the technologies. Improvement of existing technologies, and qualification method have been widely studied. However, at the other hand, specific technologies was developped : The Silicon On Insulator technologies for CMOS or Bipolar. The HSOI3HD technology (supported by DGA-CEA DAM and LETI with THOMSON TMS) offers today the highest hardening level for the integration density of hundreds of thousand transistors on the same silicon. Full complex systems would be realized on a single die with a technological radiation hardening and no more system hardening

  4. Radiation hardened COTS-based 32-bit microprocessor

    International Nuclear Information System (INIS)

    Haddad, N.; Brown, R.; Cronauer, T.; Phan, H.

    1999-01-01

    A high performance radiation hardened 32-bit RISC microprocessor based upon a commercial single chip CPU has been developed. This paper presents the features of radiation hardened microprocessor, the methods used to radiation harden this device, the results of radiation testing, and shows that the RAD6000 is well-suited for the vast majority of space applications. (authors)

  5. Molecular analysis of Rv0679c and Rv0180c genes of Mycobacterium tuberculosis from clinical isolates of pulmonary tuberculosis

    Directory of Open Access Journals (Sweden)

    L Rupa

    2016-01-01

    Full Text Available Context: Two novel proteins/genes Rv0679c and Rv0180c of Mycobacterium tuberculosis (MTB H37Rv were classified as a hypothetical membrane and transmembrane proteins which might have a role in the invasion. Molecular analysis of these genes in human clinical isolates of pulmonary tuberculosis (PTB patients was not well characterised. Aims: To assess the molecular diversity of Rv0679c and Rv0180c genes of MTB from clinical isolates of PTB patients. Settings and Design: DNA from 97 clinical isolates was extracted and subjected to amplification using selective primers by polymerase chain reaction (PCR. The PCR product obtained was sequenced commercially. Patients and Methods: Clinical isolates obtained from tuberculosis patients were investigated for polymorphisms in the Rv0679c and Rv0180c genes by PCR and DNA sequencing. Genomic DNA isolated by cetyltrimethylammonium bromide method was used for amplification of genes. Results: Rv0679c gene was highly conserved in 61 out of 65 clinical isolates assessed for sequence homology with wild-type H37Rv gene and was identical using ClustalW. Fifty-five out of 78 (70.5% clinical isolates assessed for Rv0180c were positive for single nucleotide polymorphism (SNP at 258th position where the nucleotide G was replaced with T (G to T. In clinical isolates of untreated cases, the frequency was 54.5% for SNP at 258th position which is low compared to cases undergoing treatment where the frequency was 73.1%. Conclusions: Molecular analysis of Rv0180c in clinical isolates of PTB assessed in this study was the first report, where an SNP at 258th position G to T was identified within the gene. Rv0679c gene was highly conserved (94%, within Indian clinical isolates as compared to reports from other nations.

  6. Kohtujurist Ivo Raudjärv peab etteheiteid maksuametile põhjendatuiks / Ivo Raudjärv ; interv. Edith Kiilmaa

    Index Scriptorium Estoniae

    Raudjärv, Ivo, 1976-

    2003-01-01

    Maksumaksja intervjuu juristibüroo Raudjärv & Ko UÜ juhataja Ivo Raudjärvega. Kommentaarid: Lasse Lehis (TÜ finantsõiguse dotsent, Riigikohtu halduskolleegiumi nõunik) "Ivo Raudjärv - asendamatu asjatundja", Aivar Pau (Maksuameti pressiesindaja) "Maksuameti statistika põhineb jõustunud kohtulahenditel", Jüri Allikalt (Jüri Allikaltþi õigusbüroo jurist-maksukonsultant) "Analüütiline Ivo Raudjärv". Lisatud Ivo Raudjärve CV

  7. The secondary hardening phenomenon in strain-hardened MP35N alloy

    International Nuclear Information System (INIS)

    Asgari, S.; El-Danaf, E.; Shaji, E.; Kalidindi, S.R.; Doherty, R.D.

    1998-01-01

    Mechanical testing and microscopy techniques were used to investigate the influence of aging on the structure and strengthening of MP35N alloy. It was confirmed that aging the deformed material at 600 C for 4 h provided additional strengthening, here referred to as secondary hardening, in addition to the primary strain hardening. The secondary hardening phenomenon was shown to be distinctly different from typical age hardening processes in that it only occurred in material deformed beyond a certain cold work level. At moderate strains, aging caused a shift in the entire stress-strain curve of the annealed material to higher stresses while at high strains, it produced shear localization and limited work softening. The secondary hardening increment was also found to be grain size dependent. The magnitude of the secondary hardening appeared to be controlled by the flow stress in the strain hardened material. A model is proposed to explain the observations and is supported by direct experimental evidence. The model is based on formation of h.c.p. nuclei through the Suzuki mechanism, that is segregation of solute atoms to stacking faults, on aging the strain hardened material. The h.c.p. precipitates appear to thicken only in the presence of high dislocation density produced by prior cold work

  8. Influence of Microstructure and Process Conditions on Simultaneous Low-Temperature Surface Hardening and Bulk Precipitation Hardening of Nanoflex®

    DEFF Research Database (Denmark)

    Bottoli, Federico; Winther, Grethe; Christiansen, Thomas L.

    2015-01-01

    Precipitation hardening martensitic stainless steel Nanoflex was low-temperature nitrided or nitrocarburized. In these treatments, simultaneous hardening of the bulk, by precipitation hardening, and the surface by dissolving nitrogen/carbon can be obtained because the treatment temperatures...... and times for these essentially different hardening mechanisms are compatible. The effect of the processing history of the steel on the nitrided/nitrocarburized case was investigated by varying the amounts of austenite and martensite through variation of the degree of plastic deformation by tensile strain...... consisting of martensite results in the deepest nitrided case, while a shallow case develops on a microstructure consisting of austenite. For an initial microstructure consisting of both martensite and austenite a non-uniform case depth is achieved. Simultaneous bulk and surface hardening is only possible...

  9. A hardenability test proposal

    Energy Technology Data Exchange (ETDEWEB)

    Murthy, N.V.S.N. [Ingersoll-Rand (I) Ltd., Bangalore (India)

    1996-12-31

    A new approach for hardenability evaluation and its application to heat treatable steels will be discussed. This will include an overview and deficiencies of the current methods and discussion on the necessity for a new approach. Hardenability terminology will be expanded to avoid ambiguity and over-simplification as encountered with the current system. A new hardenability definition is proposed. Hardenability specification methods are simplified and rationalized. The new hardenability evaluation system proposed here utilizes a test specimen with varying diameter as an alternative to the cylindrical Jominy hardenability test specimen and is readily applicable to the evaluation of a wide variety of steels with different cross-section sizes.

  10. Comparison of Thermal Creep Strain Calculation Results Using Time Hardening and Strain Hardening Rules

    International Nuclear Information System (INIS)

    Kim, Junehyung; Cheon, Jinsik; Lee, Byoungoon; Lee, Chanbock

    2014-01-01

    One of the design criteria for the fuel rod in PGSFR is the thermal creep strain of the cladding, because the cladding is exposed to a high temperature for a long time during reactor operation period. In general, there are two kind of calculation scheme for thermal creep strain: time hardening and strain hardening rules. In this work, thermal creep strain calculation results for HT9 cladding by using time hardening and strain hardening rules are compared by employing KAERI's current metallic fuel performance analysis code, MACSIS. Also, thermal creep strain calculation results by using ANL's metallic fuel performance analysis code, LIFE-METAL which adopts strain hardening rule are compared with those by using MACSIS. Thermal creep strain calculation results for HT9 cladding by using time hardening and strain hardening rules were compared by employing KAERI's current metallic fuel performance analysis code, MACSIS. Also, thermal creep strain calculation results by using ANL's metallic fuel performance analysis code, LIFE-METAL which adopts strain hardening rule were compared with those by using MACSIS. Tertiary creep started earlier in time hardening rule than in strain hardening rule. Also, calculation results by MACSIS with strain hardening and those obtained by using LIFE-METAL were almost identical to each other

  11. Radiation-hardenable diluents for radiation-hardenable compositions

    International Nuclear Information System (INIS)

    Schuster, K.E.; Rosenkranz, H.J.; Furh, K.; Ruedolph, H.

    1979-01-01

    Radiation-crosslinkable diluents for radiation-hardenable compositions (binders) consisting of a mixture of triacrylates of a reaction product of trimethylol propane and ethylene oxide with an average degree of ethoxylation of from 2.5 to 4 are described. The ethoxylated trimethylol propane is substantially free from trimethylol propane and has the following distribution: 4 to 5% by weight of monoethoxylation product, 14 to 16% by weight of diethoxylation product, 20 to 30% by weight of triethoxylation product, 20 to 30% by weight of tetraethoxylation product, 16 to 18% by weight of pentaethoxylation product, and 6 to 8% by weight of hexaethoxylation product. The diluents effectively reduce the viscosity of radiation-hardenable compositions and do not have any adverse effect upon their reactivity or upon the properties of the resulting hardened products

  12. Influence of Cooling Condition on the Performance of Grinding Hardened Layer in Grind-hardening

    Science.gov (United States)

    Wang, G. C.; Chen, J.; Xu, G. Y.; Li, X.

    2018-02-01

    45# steel was grinded and hardened on a surface grinding machine to study the effect of three different cooling media, including emulsion, dry air and liquid nitrogen, on the microstructure and properties of the hardened layer. The results show that the microstructure of material surface hardened with emulsion is pearlite and no hardened layer. The surface roughness is small and the residual stress is compressive stress. With cooling condition of liquid nitrogen and dry air, the specimen surface are hardened, the organization is martensite, the surface roughness is also not changed, but high hardness of hardened layer and surface compressive stress were obtained when grinding using liquid nitrogen. The deeper hardened layer grinded with dry air was obtained and surface residual stress is tensile stress. This study provides an experimental basis for choosing the appropriate cooling mode to effectively control the performance of grinding hardened layer.

  13. Precipitation and Hardening in Magnesium Alloys

    Science.gov (United States)

    Nie, Jian-Feng

    2012-11-01

    Magnesium alloys have received an increasing interest in the past 12 years for potential applications in the automotive, aircraft, aerospace, and electronic industries. Many of these alloys are strong because of solid-state precipitates that are produced by an age-hardening process. Although some strength improvements of existing magnesium alloys have been made and some novel alloys with improved strength have been developed, the strength level that has been achieved so far is still substantially lower than that obtained in counterpart aluminum alloys. Further improvements in the alloy strength require a better understanding of the structure, morphology, orientation of precipitates, effects of precipitate morphology, and orientation on the strengthening and microstructural factors that are important in controlling the nucleation and growth of these precipitates. In this review, precipitation in most precipitation-hardenable magnesium alloys is reviewed, and its relationship with strengthening is examined. It is demonstrated that the precipitation phenomena in these alloys, especially in the very early stage of the precipitation process, are still far from being well understood, and many fundamental issues remain unsolved even after some extensive and concerted efforts made in the past 12 years. The challenges associated with precipitation hardening and age hardening are identified and discussed, and guidelines are outlined for the rational design and development of higher strength, and ultimately ultrahigh strength, magnesium alloys via precipitation hardening.

  14. Numerical and experimental comparison of plastic work-hardening rules

    International Nuclear Information System (INIS)

    Haisler, W.E.

    1977-01-01

    The purpose of this paper is to describe recent numerical and experimental correlation studies of several plastic work-hardening rules. The mechanical sublayer model and the combined kinematic-isotropic hardening rules are examined and the numerical results for several structural geometries are compared to experimental results. Both monotonic and cyclic loads are considered. The governing incremental plasticity relations are developed for both work-hardening models. The combined kinematic-isotropic hardening model is developed in terms of a ratio γ which controls the relative contribution of kinematic hardening (yield surface translation) and isotropic hardening (yield surface expansion). In addition to making use of a uniaxial stress-strain curve as input data, the model allows for the input of a yield surface size vs. uniaxial plastic strain curve obtained from a cyclic uniaxial reverse loading test. The mechanical sublayer model is developed in general form and a new method for determining the sublayer parameters (stress weighting factors and yield stresses) is presented. It is demonstrated that former procedures used to obtain the sublayer parameters are inconsistent for multiaxial loading. Numerical and experimental results are presented for a cylinder, circular plate with punch, and a steel pressure vessel. The numerical results are obtained with the computer program AGGIE I. The comparison study indicates that reasonable agreement is obtained with both hardening models; the choice depending upon whether the loading is monotonic or cyclic

  15. Cellular and molecular basis of RV hypertrophy in congenital heart disease.

    Science.gov (United States)

    Iacobazzi, D; Suleiman, M-S; Ghorbel, M; George, S J; Caputo, M; Tulloh, R M

    2016-01-01

    RV hypertrophy (RVH) is one of the triggers of RV failure in congenital heart disease (CHD). Therefore, improving our understanding of the cellular and molecular basis of this pathology will help in developing strategic therapeutic interventions to enhance patient benefit in the future. This review describes the potential mechanisms that underlie the transition from RVH to RV failure. In particular, it addresses structural and functional remodelling that encompass contractile dysfunction, metabolic changes, shifts in gene expression and extracellular matrix remodelling. Both ischaemic stress and reactive oxygen species production are implicated in triggering these changes and will be discussed. Finally, RV remodelling in response to various CHDs as well as the potential role of biomarkers will be addressed. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  16. Analysis on Dynamic Transmission Accuracy for RV Reducer

    Directory of Open Access Journals (Sweden)

    Zhang Fengshou

    2017-01-01

    Full Text Available By taking rotate vector (RV reducer as the research object, the factors affecting the transmission accuracy are studied, including the machining errors of the main parts, assembly errors, clearance, micro-displacement, gear mesh stiffness and damping, bearing stiffness. Based on Newton second law, the transmission error mathematical model of RV reducer is set up. Then, the RV reducer transmission error curve is achieved by solving the mathematical model using the Runge-Kutta methods under the combined action of various error factors. Through the analysis of RV reducer transmission test, it can be found that there are similar variation trend and frequency components compared the theoretical research and experimental result. The presented method is useful to the research on dynamic transmission accuracy of RV reducer, and also applies to research the transmission accuracy of other cycloid drive systems.

  17. The microstructural origin of work hardening stages

    DEFF Research Database (Denmark)

    Hughes, D. A.; Hansen, N.

    2018-01-01

    The strain evolution of the flow stress and work hardening rate in stages III and IV is explored by utilizing a fully described deformation microstructure. Extensive measurements by transmission electron microscopy reveal a hierarchical subdivision of grains by low angle incidental dislocation...... addition of the classical Taylor and Hall-Petch formulations. Model predictions agree closely with experimental values of flow stress and work hardening rate in stages III and IV. Strong connections between the evolutionary stages of the deformation microstructure and work hardening rates create a new...... (modern) basis for the classic problem of work hardening in metals and alloys. These connections lead the way for the future development of ultra high strength ductile metals produced via plastic deformation.(c) 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved....

  18. Application of submerged induction hardening; Ekichu koshuha yakiire no jitsuyoka

    Energy Technology Data Exchange (ETDEWEB)

    Nishimori, Y; Nagai, Y; Amii, Y [Mazda Motor Corp., Hiroshima (Japan); Tanaka, Y [Netsuren Co. Ltd., Tokyo (Japan); Mizuma, T [Toyo Advanced Technologies Co. Ltd., Hiroshima (Japan)

    1997-10-01

    As a cost-cutting measure, the linerless diesel engine was adopted by applying submerged induction hardening process which can harden partial inner surface of cylinder block bore. In applying this process, (1) development of induction coil which can form any shape of quenched pattern and (2) the development of machining technology which can hone precisely the distorted bore after quenching, were important. With these improvements, submerged Induction hardening was made practical. 1 ref., 11 figs.

  19. Chemical Compositions of RV Tauri Stars and Related Objects

    Science.gov (United States)

    Rao, S. S.; Giridhar, S.

    2014-04-01

    We have undertaken a comprehensive abundance analysis for a sample of relatively unexplored RV Tauri and RV Tauri like stars to further our understanding of post-Asymptotic Giant Branch (post-AGB) evolution. From our study based on high resolution spectra and a grid of model atmospheres, we find indications of mild s-processing for V820 Cen and IRAS 06165+3158. On the other hand, SU Gem and BT Lac exhibit the effects of mild dust-gas winnowing. We have also compiled the existing abundance data on RV Tauri objects and find that a large fraction of them are afflicted by dust-gas winnowing and aided by the present work, we find a small group of two RV Tauris showing mild s-process enhancement in our Galaxy. With two out of three reported s-process enhanced objects belonging to RV Tauri spectroscopic class C, these intrinsically metal-poor objects appear to be promising candidates to analyse the possible s-processing in RV Tauri stars.

  20. Technologies Enabling Custom Radiation-Hardened Component Development, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Two primary paths are available for the creation of a Rad-Hard ASIC. The first approach is to use a radiation hardened process such as existing Rad-Hard foundries....

  1. A non-linear kinematic hardening function

    International Nuclear Information System (INIS)

    Ottosen, N.S.

    1977-05-01

    Based on the classical theory of plasticity, and accepting the von Mises criterion as the initial yield criterion, a non-linear kinematic hardening function applicable both to Melan-Prager's and to Ziegler's hardening rule is proposed. This non-linear hardening function is determined by means of the uniaxial stress-strain curve, and any such curve is applicable. The proposed hardening function considers the problem of general reversed loading, and a smooth change in the behaviour from one plastic state to another nearlying plastic state is obtained. A review of both the kinematic hardening theory and the corresponding non-linear hardening assumptions is given, and it is shown that material behaviour is identical whether Melan-Prager's or Ziegler's hardening rule is applied, provided that the von Mises yield criterion is adopted. (author)

  2. Radiation-hardened control system

    International Nuclear Information System (INIS)

    Vandermolen, R.I.; Smith, S.F.; Emery, M.S.

    1993-01-01

    A radiation-hardened bit-slice control system with associated input/output circuits was developed to prove that programmable circuits could be constructed to successfully implement intelligent functions in a highly radioactive environment. The goal for this effort was to design and test a programmable control system that could withstand a minimum total dose of 10 7 rads (gamma). The Radiation Hardened Control System (RHCS) was tested in operation at a dose rate that ranged up to 135 krad/h, with an average total dose of 10.75 Mrads. Further testing beyond the required 10 7 rads was also conducted. RHCS performed properly through the target dose of 10 7 rads, and sporadic intermittent failures in some programmable logic devices were noted after ∼ 13 Mrads

  3. Superheat effect on bainite steel hardenability

    International Nuclear Information System (INIS)

    Kubachek, V.V.; Sklyuev, P.V.

    1978-01-01

    The bainite hardenability of 34KhN1M and 35 KhN1M2Ph steels has been investigated by the end-face hardening technique. It is established that, as the temperature of austenitization rises from 900 to 1280 deg C, the temperature of bainite transformation increases and bainite hardenability of the steels falls off. A repeated slow heating to 900 deg C of previously overheated 34KhN1M steel breaks up grain, lowers the temperature of the bainite transformation and raises the hardenability to values obtained with ordinary hardening from 900 deg C. A similar heating of previously overheated 35KhN1M2Ph steel is accompanied by restoration of initial coarse grains and maintenance of both the elevated bainite transformation temperature and to lower hardenability corresponding to hardening from the temperature of previous overheating

  4. Development of a radiation hardened ANDROS robot for environmental restoration and waste management operations

    International Nuclear Information System (INIS)

    Tulenko, J.S.; Youk, G.; Ekdahl, D.; Liu, H.; Zhou, H.; Phillips, K.; Sias, F.; Jones, S.; Cable, T.; Harvey, H.

    1995-01-01

    A radiation hardened and tolerant version of the ANDROS V-A and VI-A system has been developed by a team composed of engineers and scientists from REMOTEC, Inc. and the University of Florida. The final upgrade of the major control components to a hardness level greater than one megarad is detailed. Over twelve hundred parts were reviewed. The project has completed its Phase 1 and Phase 2 SBIR redesign with the upgrade of all control components. The facilities at the University of Florida which include a linear accelerator and multiple cobalt irradiators have provided the capability to perform the extensive testing required. The commercial production of this radiation hardened ANDROS makes available a mobile platform that can serve as a main work and inspection system for hazardous tasks facing the world nuclear industry

  5. Plastic limit pressure of spherical vessels with combined hardening involving large deformation

    International Nuclear Information System (INIS)

    Leu, S.-Y.; Liao, K.-C.; Lin, Y.-C.

    2014-01-01

    The paper aims to investigate plastic limit pressure of spherical vessels of nonlinear combined isotropic/kinematic hardening materials. The Armstrong-Frederick kinematic hardening model is adopted and the Voce hardening law is incorporated for isotropic hardening behavior. Analytically, we extend sequential limit analysis to deal with combined isotropic/kinematic hardening materials. Further, exact solutions of plastic limit pressure were developed analytically by conducting both static and kinematic limit analysis. The onset of instability was also derived and solved iteratively by Newton's method. Numerically, elastic–plastic analysis is also performed by the commercial finite-element code ABAQUS incorporated with the user subroutine UMAT implemented with user materials of combined hardening. Finally, the problem formulation and the solution derivations presented here are validated by a very good agreement between the numerical results of exact solutions and the results of elastic–plastic finite-element analysis by ABAQUS. -- Highlights: • Sequential limit analysis is extended to consider combined hardening. • Exact solutions of plastic limit pressure are developed. • The onset of instability of a spherical vessel is derived and solved numerically

  6. Radiation-hardened bulk Si-gate CMOS microprocessor family

    International Nuclear Information System (INIS)

    Stricker, R.E.; Dingwall, A.G.F.; Cohen, S.; Adams, J.R.; Slemmer, W.C.

    1979-01-01

    RCA and Sandia Laboratories jointly developed a radiation-hardened bulk Si-gate CMOS technology which is used to fabricate the CDP-1800 series microprocessor family. Total dose hardness of 1 x 10 6 rads (Si) and transient upset hardness of 5 x 10 8 rads (Si)/sec with no latch up at any transient level was achieved. Radiation-hardened parts manufactured to date include the CDP-1802 microprocessor, the CDP-1834 ROM, the CDP-1852 8-bit I/O port, the CDP-1856 N-bit 1 of 8 decoder, and the TCC-244 256 x 4 Static RAM. The paper is divided into three parts. In the first section, the basic fundamentals of the non-hardened C 2 L technology used for the CDP-1800 series microprocessor parts is discussed along with the primary reasons for hardening this technology. The second section discusses the major changes in the fabrication sequence that are required to produce radiation-hardened devices. The final section details the electrical performance characteristics of the hardened devices as well as the effects of radiation on device performance. Also included in this section is a discussion of the TCC-244 256 x 4 Static RAM designed jointly by RCA and Sandia Laboratories for this application

  7. Developing precipitation hardenable high entropy alloys

    Science.gov (United States)

    Gwalani, Bharat

    High entropy alloys (HEAs) is a concept wherein alloys are constructed with five or more elements mixed in equal proportions; these are also known as multi-principle elements (MPEs) or complex concentrated alloys (CCAs). This PhD thesis dissertation presents research conducted to develop precipitation-hardenable high entropy alloys using a much-studied fcc-based equi-atomic quaternary alloy (CoCrFeNi). Minor additions of aluminium make the alloy amenable for precipitating ordered intermetallic phases in an fcc matrix. Aluminum also affects grain growth kinetics and Hall-Petch hardenability. The use of a combinatorial approach for assessing composition-microstructure-property relationships in high entropy alloys, or more broadly in complex concentrated alloys; using laser deposited compositionally graded AlxCrCuFeNi 2 (0 mechanically processed via conventional techniques. The phase stability and mechanical properties of these alloys have been investigated and will be presented. Additionally, the activation energy for grain growth as a function of Al content in these complex alloys has also been investigated. Change in fcc grain growth kinetic was studied as a function of aluminum; the apparent activation energy for grain growth increases by about three times going from Al0.1CoCrFeNi (3% Al (at%)) to Al0.3CoCrFeNi. (7% Al (at%)). Furthermore, Al addition leads to the precipitation of highly refined ordered L12 (gamma') and B2 precipitates in Al0.3CoCrFeNi. A detailed investigation of precipitation of the ordered phases in Al0.3CoCrFeNi and their thermal stability is done using atom probe tomography (APT), transmission electron microscopy (TEM) and Synchrotron X-ray in situ and ex situ analyses. The alloy strengthened via grain boundary strengthening following the Hall-Petch relationship offers a large increment of strength with small variation in grain size. Tensile strength of the Al0.3CoFeNi is increased by 50% on precipitation fine-scale gamma' precipitates

  8. Transcriptional analysis of genetic region RvD1 of Mycobacterium bovis

    Directory of Open Access Journals (Sweden)

    Víctor Manuel Tibatá R.

    2004-07-01

    Full Text Available Mycobacterium bovis, shares 99.9% of genomic identity with M. tuberculosis, M. africanum and M. microti. Within this 0.1 % of difference, there are two genetic regions characteristics of M. bovis that are deleted in M. tuberculo­sis H37Rv: RvD1 and RvD2. According to bioinformatic analysis, these regions contain Open Reading Frames (ORFs. With the purpose of determining if the RvD1 region transcribes the ORFs predicted by bioinformatics (ORF1, ORF2 and Rv2024; total RNA was extracted from a culture of M. bovis BCG Pasteur, at different time points along the growth curve. The RNA samples were analyzed by Real Time Reverse Transcription - Poly-merase Chain Reaction (RTq-PCR. The findings show that ORF1, ORF2 and Rv2024, were transcribed consti-tutively, something that has not been reported previously. These results are a first step in order to determine the function of M. bovis RvD1 region, its possible role in pathogenesis and its interaction with both cattle and humans. Key words: Mycobacterium bovis, BCG, RNA, Real Time, RT-PCR, RvD1

  9. Radiation Hardened Telerobotic Dismantling System Development Final Report CRADA No. TC-1340-96

    Energy Technology Data Exchange (ETDEWEB)

    Smith, C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lightman, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-09-27

    This project was a collaborative effort between the University of California, LLNL and RedZone Robotics, Inc. for the development of radiation-hardened telerobotic dismantling systems for use in applications such as nuclear facility remediation, nuclear accident response, and Chemobyltype remediation. The project supported the design, development, fabrication and testing of a Ukrainian robotic systems. The project was completed on time and within budget. All deliverables were completed. The final project deliverables were consistent with the plans developed in the original project with the exception that the fabricated systems remained in Ukraine.

  10. Formulating the strength factor α for improved predictability of radiation hardening

    Energy Technology Data Exchange (ETDEWEB)

    Tan, L., E-mail: tanl@ornl.gov; Busby, J.T.

    2015-10-15

    Analytical equations were developed to calculate the strength factors of precipitates, Frank loops, and cavities in austenitic alloys, which strongly depend on barrier type, size, geometry and density, as well as temperature. Calculated strength factors were successfully used to estimate radiation hardening using the broadly employed dispersed barrier-hardening model, leading to good agreement with experimentally measured hardening in neutron-irradiated type 304 and 316 stainless steel variants. The formulated strength factor provides a route for more reliable hardening predictions and can be easily incorporated into component simulations and design.

  11. Computer modelling of age hardening for cast aluminium alloys

    International Nuclear Information System (INIS)

    Wu, Linda; Ferguson, W George

    2009-01-01

    Age hardening, or precipitation hardening, is one of the most widely adopted techniques for strengthening of aluminium alloys. Although various age hardening models have been developed for aluminium alloys, from the large volume of literature reviewed, it appears that the bulk of the research has been concentrated on wrought aluminium alloys, only a few of the established precipitation models have been applied to the casting aluminium alloys. In the present work, there are two modelling methods that have been developed and applied to the casting aluminium alloys A356 and A357. One is based on the Shercliff-Ashby methodology to produce a process model, by which we mean a mathematical relationship between process variables (alloy composition, ageing temperature and time) and material properties (yield strength or hardness) through microstructure evolution (precipitate radius, volume fraction). The other method is based on the Kampmann and Wagner Numerical (KWN) model which deals with concomitant nucleation, growth and coarsening and is thus capable of predicting the full evolution of the particle size distribution and then a strength model is used to evaluate the resulting change in hardness or yield strength at room temperature by taking into account contributions from lattice resistance, solid solution hardening and precipitation hardening.

  12. The Use of Fuzzy Systems for Forecasting the Hardenability of Steel

    Directory of Open Access Journals (Sweden)

    Sitek W.

    2016-06-01

    Full Text Available The goal of the research carried out was to develop the fuzzy systems, allowing the determination of the Jominy hardenability curve based on the chemical composition of structural steels for quenching and tempering. Fuzzy system was created to calculate hardness of the steel, based on the alloying elements concentrations, and to forecast the hardenability curves. This was done based on information from the PN-EN 10083-3: 2008. Examples of hardenability curves calculated for exemplar steels were presented. Results of the research confirmed that fuzzy systems are a useful tool in evaluation the effect of alloying elements on the properties of materials compared to conventional methods. It has been demonstrated the practical usefulness of the developed models which allows forecasting the steels’ Jominy hardenability curve.

  13. Grind hardening process

    CERN Document Server

    Salonitis, Konstantinos

    2015-01-01

    This book presents the grind-hardening process and the main studies published since it was introduced in 1990s.  The modelling of the various aspects of the process, such as the process forces, temperature profile developed, hardness profiles, residual stresses etc. are described in detail. The book is of interest to the research community working with mathematical modeling and optimization of manufacturing processes.

  14. Stage IV work-hardening related to disorientations in dislocation structures

    DEFF Research Database (Denmark)

    Pantleon, W.

    2004-01-01

    The effect of deformation-induced disorientations on the work-hardening of metals is modelled based on dislocation dynamics. Essentially, Kocks’ dislocation model describing stage III hardening is extended to stage IV by incorporation of excess dislocations related to the disorientations....... Disorientations evolving from purely statistical reasons — leading to a square root dependence of the average disorientation angle on strain — affect the initial work-hardening rate (and the saturation stress) of stage III only slightly. On the other hand, deterministic contributions to the development...... of disorientations, as differences in the activated slip systems across boundaries, cause a linear increase of the flow stress at large strains. Such a constant work-hardening rate is characteristic for stage IV....

  15. Aspect-oriented security hardening of UML design models

    CERN Document Server

    Mouheb, Djedjiga; Pourzandi, Makan; Wang, Lingyu; Nouh, Mariam; Ziarati, Raha; Alhadidi, Dima; Talhi, Chamseddine; Lima, Vitor

    2015-01-01

    This book comprehensively presents a novel approach to the systematic security hardening of software design models expressed in the standard UML language. It combines model-driven engineering and the aspect-oriented paradigm to integrate security practices into the early phases of the software development process. To this end, a UML profile has been developed for the specification of security hardening aspects on UML diagrams. In addition, a weaving framework, with the underlying theoretical foundations, has been designed for the systematic injection of security aspects into UML models. The

  16. Phase I trial of RV3-BB rotavirus vaccine: a human neonatal rotavirus vaccine.

    Science.gov (United States)

    Danchin, M; Kirkwood, C D; Lee, K J; Bishop, R F; Watts, E; Justice, F A; Clifford, V; Cowley, D; Buttery, J P; Bines, J E

    2013-05-28

    RV3 is a human neonatal rotavirus strain (G3P[6]) that has been associated with asymptomatic neonatal infection and replicates well in the infant gut. RV3-BB rotavirus vaccine has been developed as a rotavirus vaccine candidate for administration at birth. A single-centre, double-blind, randomised placebo-controlled Phase I study evaluated the safety and tolerability of a single oral dose of the second generation RV3-BB rotavirus vaccine (8.3×10(6)FFU/mL) in 20 adults, 20 children and 20 infants (10 vaccine and 10 placebo per age cohort). Vaccine take was defined as seroconversion (a 3-fold increase in serum anti-rotavirus IgA or serum neutralising antibody (SNA) from baseline at day 28 post-dose) or evidence of RV3-BB viral replication in the faeces by RT-PCR analysis 3-6 days post-vaccination. RV3-BB presence was confirmed by sequence analysis. The RV3-BB vaccine was well tolerated in all participants, with no pattern of adverse events shown to be associated with the study vaccine. In the infant cohort, vaccine take was demonstrated in 8/9 infants following a single dose of vaccine compared with 2/7 placebo recipients. In the infant vaccine group, 5/9 infants exhibited either IgA or SNA seroconversion and 7/9 infants had evidence of RV3-BB replication on days 3-6, compared with 2/7 infants who seroconverted and 0/10 infants with evidence of replication in the placebo group. Two infants in the placebo group had serological evidence of a rotavirus infection within the 28-day study period: one demonstrated an IgA and the other an SNA response, with wild-type virus replication detected in another infant. A single dose of RV3-BB rotavirus vaccine was well tolerated in adults, children and infants. Most infants (8/9) who received RV3-BB demonstrated vaccine take following a single dose. These data support progression of RV3-BB to Phase II immunogenicity and efficacy trials. Copyright © 2013 Elsevier Ltd. All rights reserved.

  17. Strain-hardening behavior and microstructure development in polycrystalline as-cast Mg-Zn-Y alloys with LPSO phase subjected to cyclic loading

    Energy Technology Data Exchange (ETDEWEB)

    Shiraishi, Kazuma [Department of Materials Science and Engineering, Kumamoto University, 2-39-1, Kurokami, Chuo-ku, Kumamoto 860-8555 (Japan); Mayama, Tsuyoshi, E-mail: mayama@kumamoto-u.ac.jp [Priority Organization for Innovation and Excellence, Kumamoto University, 2-39-1, Kurokami, Chuo-ku, Kumamoto 860-8555 (Japan); Department of Materials Science and Engineering, University of Virginia, Charlottesville, VA 22904 (United States); Yamasaki, Michiaki [School of Mechanical and Mining Engineering, The University of Queensland, St Lucia, Brisbane, Qld 4072 (Australia); Magnesium Research Center/Department of Materials Science and Engineering, Kumamoto University, 2-39-1, Kurokami, Chuo-ku, Kumamoto 860-8555 (Japan); Kawamura, Yoshihito [Magnesium Research Center/Department of Materials Science and Engineering, Kumamoto University, 2-39-1, Kurokami, Chuo-ku, Kumamoto 860-8555 (Japan)

    2016-08-30

    The strain-hardening behavior and microstructural development of polycrystalline as-cast Mg-Zn-Y alloys with various volume fractions of the long-period stacking ordered (LPSO) phase subjected to cyclic loading were experimentally evaluated. For all alloys, cyclic loading tests with a constant strain amplitude of 0.5% for up to 100 cycles showed asymmetric cyclic hardening behavior. That is, the absolute value of the compressive peak stress significantly increased during cyclic loading while the tensile peak stress slightly decreased. With increasing volume fraction of the LPSO phase, the stress amplitude significantly increased. Cyclic loading tests after compressive preloading up to 200 or 250 MPa resulted in a significant increase in the stress amplitude, while a number of kink bands developed during preloading. For the cyclic hardening behavior, the contribution of the increase in kinematic hardening was significant in the alloys with a higher volume fraction of the LPSO phase. Transmission electron microscopy observation of the cyclically deformed Mg{sub 85}Zn{sub 6}Y{sub 9} alloy indicated the formation of a deformation-induced band, where the crystal structure was transformed from 18R-LPSO to hcp-Mg with the exclusion of solute elements.

  18. Rotavirus shedding following administration of RV3-BB human neonatal rotavirus vaccine.

    Science.gov (United States)

    Cowley, Daniel; Boniface, Karen; Bogdanovic-Sakran, Nada; Kirkwood, Carl D; Bines, Julie E

    2017-08-03

    The RV3-BB human neonatal rotavirus vaccine aims to provide protection from severe rotavirus disease from birth. A phase IIa safety and immunogenicity trial was undertaken in Dunedin, New Zealand between January 2012 and April 2014. Healthy, full-term (≥ 36 weeks gestation) babies, who were 0-5 d old were randomly assigned (1:1:1) to receive 3 doses of oral RV3-BB vaccine with the first dose given at 0-5 d after birth (neonatal schedule), or the first dose given at about 8 weeks after birth (infant schedule), or to receive placebo (placebo schedule). Vaccine take (serum immune response or stool shedding of vaccine virus after any dose) was detected after 3 doses of RV3-BB vaccine in >90% of participants when the first dose was administered in the neonatal and infant schedules. The aim of the current study was to characterize RV3-BB shedding and virus replication following administration of RV3-BB in a neonatal and infant vaccination schedule. Shedding was defined as detection of rotavirus by VP6 reverse transcription polymerase chain reaction (RT-PCR) in stool on days 3-7 after administration of RV3-BB. Shedding of rotavirus was highest following vaccination at 8 weeks of age in both neonatal and infant schedules (19/30 and 17/27, respectively). Rotavirus was detected in stool on days 3-7, after at least one dose of RV3-BB, in 70% (21/30) of neonate, 78% (21/27) of infant and 3% (1/32) placebo participants. In participants who shed RV3-BB, rotavirus was detectable in stool on day 1 following RV3-BB administration and remained positive until day 4-5 after administration. The distinct pattern of RV3-BB stool viral load demonstrated using a NSP3 quantitative qRT-PCR in participants who shed RV3-BB, suggests that detection of RV3-BB at day 3-7 was the result of replication rather than passage through the gastrointestinal tract.

  19. Designing of the chemical composition of steels basing on the hardenability of constructional steels

    International Nuclear Information System (INIS)

    Dobrzanski, L.A.; Sitek, W.

    2003-01-01

    The paper presents the original method of modelling of the relationships between chemical composition of alloy constructional steel and its hardenability, employing neural networks. Basing on the experimental results of the hardenability investigations, which employed Jominy method, the model of the neural networks was developed and fully verified experimentally. The model makes it possible to obtain Jominy hardenability curves basing on the steel chemical composition. The model of neural networks, making it possible to design the steel chemical composition, basing on the known Jominy hardenability curve shape, was developed also and fully verified numerically. (author)

  20. Scintillation-Hardened GPS Receiver

    Science.gov (United States)

    Stephens, Donald R.

    2015-01-01

    CommLargo, Inc., has developed a scintillation-hardened Global Positioning System (GPS) receiver that improves reliability for low-orbit missions and complies with NASA's Space Telecommunications Radio System (STRS) architecture standards. A software-defined radio (SDR) implementation allows a single hardware element to function as either a conventional radio or as a GPS receiver, providing backup and redundancy for platforms such as the International Space Station (ISS) and high-value remote sensing platforms. The innovation's flexible SDR implementation reduces cost, weight, and power requirements. Scintillation hardening improves mission reliability and variability. In Phase I, CommLargo refactored an open-source GPS software package with Kalman filter-based tracking loops to improve performance during scintillation and also demonstrated improved navigation during a geomagnetic storm. In Phase II, the company generated a new field-programmable gate array (FPGA)-based GPS waveform to demonstrate on NASA's Space Communication and Navigation (SCaN) test bed.

  1. Development of production methods of volume source by the resinous solution which has hardening

    CERN Document Server

    Motoki, R

    2002-01-01

    Volume sources is used for standard sources by radioactive measurement using Ge semiconductor detector of environmental sample, e.g. water, soil and etc. that require large volume. The commercial volume source used in measurement of the water sample is made of agar-agar, and that used in measurement of the soil sample is made of alumina powder. When the plastic receptacles of this two kinds of volume sources were damaged, the leakage contents cause contamination. Moreover, if hermetically sealing performance of volume source made of agar-agar fell, volume decrease due to an evaporation off moisture gives an error to radioactive measurement. Therefore, we developed the two type methods using unsaturated polyester resin, vinilester resin, their hardening agent and acrylicresin. The first type is due to dispersing the hydrochloric acid solution included the radioisotopes uniformly in each resin and hardening the resin. The second is due to dispersing the alumina powder absorbed the radioisotopes in each resin an...

  2. 1993 recreational vehicle (RV) park census in Beatty and Pahrump, Nevada

    International Nuclear Information System (INIS)

    Levy, L.E.; Housel, M.D.

    1994-01-01

    This paper reports on the second annual study of seasonal nonpermanent residents in the towns of Beatty and Pahrump in southern Nye County, Nevada, situs county of the Yucca Mountain Site Characterization Project. The study used a census of recreational vehicle (RV) park managers to enumerate and characterize in demographic terms nonpermanent residents staying in RV parks. The questionnaire sought information from RV park managers which ordinarily would come from a household survey. The main objective was to study open-quotes snowbirdsclose quotes, the households of older couples who stay for a month or more each winter. The findings suggest that snowbirds are a majority of the seasonal influx of nonpermanent residents to RV parks in Pahrump. In contrast, a group called open-quotes seasonal travelersclose quotes, similar demographically but who stay less than a month, dominate the seasonal nonpermanent population in Beatty's RV parks. The study also tentatively identified the seasonality of nonpermanent resident occupancy. Because only RV parks were contacted, the study left unanswered the question of how many snowbirds live in other types of accommodations in Beatty and Pahrump

  3. Working hardening modelization in zirconium alloys

    International Nuclear Information System (INIS)

    Sanchez, P.; Pochettino, Alberto A.

    1999-01-01

    Working hardening effects on mechanical properties and crystallographic textures formation in Zr-based alloys are studied. The hardening mechanisms for different grain deformations and topological conditions of simple crystal yield are considered. Results obtained show that the differences in the cold rolling textures (L and T textures) can be related with hardening microstructural parameters. (author)

  4. Practical aspects of systems hardening

    International Nuclear Information System (INIS)

    Shepherd, W.J.

    1989-01-01

    Applications of hardening technology in a practical system require a balance between the factors governing affordability, producibility, and survivability of the finished design. Without careful consideration of the top-level system operating constraints, a design engineer may find himself with a survivable but overweight, unproductive, expensive design. This paper explores some lessons learned in applying hardening techniques to several laser communications programs and is intended as an introductory guide to novice designers faced with the task of hardening a space system

  5. A novel vaccine p846 encoding Rv3615c, Mtb10.4, and Rv2660c elicits robust immune response and alleviates lung injury induced by Mycobacterium infection.

    Science.gov (United States)

    Kong, Hongmei; Dong, Chunsheng; Xiong, Sidong

    2014-01-01

    Development of effective anti-tuberculosis (TB) vaccines is one of the important steps to improve control of TB. Cell-mediated immune response significantly affects the control of M. tuberculosis infection. Thus, vaccines able to elicit strong cellular immune response hold special advantages against TB. In this study, three well-defined mycobacterial antigens (Rv3615c, Mtb10.4 [Rv0228], and Rv2660c) were engineered as a novel triple-antigen fusion DNA vaccine p846. The p846 vaccine consists of a high density of CD4(+) and CD8(+) T-cell epitopes. Intramuscular immunization of p846 induced robust T cells mediated immune response comparable to that of bacillus Calmette-Guérin (BCG) vaccination but more effective than that of individual antigen vaccination. After mycobacterial challenge, p846 immunization decreased bacterial burden at least 15-fold compared with individual antigen-based vaccination. Notably, the lungs of mice immunized with p846 exhibited fewer inflammatory cell infiltrates and less damage than those of control group mice. Our data demonstrate that the potential of p846 vaccine to protect against TB and the feasibility of this design strategy for further TB vaccine development.

  6. Radial Velocities of Subgiant Stars and New Astrophysical Insights into RV Jitter

    Science.gov (United States)

    Luhn, Jacob; Bastien, Fabienne; Wright, Jason T.

    2018-01-01

    For nearly 20 years, the California Planet Search (CPS) has simultaneously monitored precise radial velocities and chromospheric activity levels of stars from Keck observatory to search for exoplanets. This sample provides a useful set of stars to better determine the dependence of RV jitter on flicker (which traces surface gravity) first shown in Bastien et al. (2014). We expand upon this initial work by examining a much larger sample of stars covering a much wider range of stellar parameters (effective temperature, surface gravity, and activity, among others). For more than 600 stars, there are enough RV measurements to distinguish this astrophysical jitter from accelerations due to orbital companions. To properly isolate RV jitter from these effects, we must first remove the RV signal due to these companions, including several previously unannounced giant planets around subgiant stars. We highlight some new results from our analysis of the CPS data. A more thorough understanding of the various sources of RV jitter and the underlying stellar phenomena that drive these intrinsic RV variations will enable more precise jitter estimates for RV follow-up targets such as those from K2 or the upcoming TESS mission.

  7. Extracting material response from simple mechanical tests on hardening-softening-hardening viscoplastic solids

    Science.gov (United States)

    Mohan, Nisha

    Compliant foams are usually characterized by a wide range of desirable mechanical properties. These properties include viscoelasticity at different temperatures, energy absorption, recoverability under cyclic loading, impact resistance, and thermal, electrical, acoustic and radiation-resistance. Some foams contain nano-sized features and are used in small-scale devices. This implies that the characteristic dimensions of foams span multiple length scales, rendering modeling their mechanical properties difficult. Continuum mechanics-based models capture some salient experimental features like the linear elastic regime, followed by non-linear plateau stress regime. However, they lack mesostructural physical details. This makes them incapable of accurately predicting local peaks in stress and strain distributions, which significantly affect the deformation paths. Atomistic methods are capable of capturing the physical origins of deformation at smaller scales, but suffer from impractical computational intensity. Capturing deformation at the so-called meso-scale, which is capable of describing the phenomenon at a continuum level, but with some physical insights, requires developing new theoretical approaches. A fundamental question that motivates the modeling of foams is `how to extract the intrinsic material response from simple mechanical test data, such as stress vs. strain response?' A 3D model was developed to simulate the mechanical response of foam-type materials. The novelty of this model includes unique features such as the hardening-softening-hardening material response, strain rate-dependence, and plastically compressible solids with plastic non-normality. Suggestive links from atomistic simulations of foams were borrowed to formulate a physically informed hardening material input function. Motivated by a model that qualitatively captured the response of foam-type vertically aligned carbon nanotube (VACNT) pillars under uniaxial compression [2011,"Analysis of

  8. DMILL circuits. The hardened electronics decuples its performances

    International Nuclear Information System (INIS)

    Anon.

    1998-01-01

    Thanks to the DMILL (mixed logic-linear hardening) technology under development at the CEA, MHS, a French company specialized in the fabrication of integrated circuits now produces hardened electronic circuits ten times more resistant to radiations than its competitors. Outside the initial market (several thousands of circuits for the LHC particle accelerator of Geneva), a broad choice of applications is opened to this technology: national defense, space, civil nuclear and medical engineering, and high temperature applications. Short paper. (J.S.)

  9. Performances of cutting fluids in turning. Vegetable based oil - RV

    DEFF Research Database (Denmark)

    Axinte, Dragos Aurelian; Belluco, Walter

    1999-01-01

    Scope of the present measurement campaign is the evaluation of the cutting fluid performance. The report presents the standard routine and the results obtained when turning stainless steel and brass with a commercial vegetable based oil called RV. The methods were developed to be applicable...

  10. RHOBOT: Radiation hardened robotics

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, P.C.; Posey, L.D. [Sandia National Labs., Albuquerque, NM (United States)

    1997-10-01

    A survey of robotic applications in radioactive environments has been conducted, and analysis of robotic system components and their response to the varying types and strengths of radiation has been completed. Two specific robotic systems for accident recovery and nuclear fuel movement have been analyzed in detail for radiation hardness. Finally, a general design approach for radiation-hardened robotics systems has been developed and is presented. This report completes this project which was funded under the Laboratory Directed Research and Development program.

  11. RHOBOT: Radiation hardened robotics

    International Nuclear Information System (INIS)

    Bennett, P.C.; Posey, L.D.

    1997-10-01

    A survey of robotic applications in radioactive environments has been conducted, and analysis of robotic system components and their response to the varying types and strengths of radiation has been completed. Two specific robotic systems for accident recovery and nuclear fuel movement have been analyzed in detail for radiation hardness. Finally, a general design approach for radiation-hardened robotics systems has been developed and is presented. This report completes this project which was funded under the Laboratory Directed Research and Development program

  12. TIME VARIATION OF AV AND RV FOR TYPE Ia SUPERNOVAE BEHIND INTERSTELLAR DUST

    Science.gov (United States)

    Huang, Xiaosheng; Biederman, M.; Herger, B.; Aldering, G. S.

    2014-01-01

    TIME VARIATION OF AV AND RV FOR TYPE Ia SUPERNOVAE BEHIND NON-UNIFORM INTERSTELLAR DUST ABSTRACT We investigate the time variation of the visual extinction, AV, and the total-to-selective extinction ratio, RV, resulting from interstellar dust in front of an expanding photospheric disk of a type Ia supernova (SN Ia). We simulate interstellar dust clouds according to a power law power spectrum and produce extinction maps that either follow a pseudo-Gaussian distribution or a lognormal distribution. The RV maps are produced through a correlation between AV and RV. With maps of AV and RV generated in each case (pseudo-Gaussian and lognormal), we then compute the effective AV and RV for a SN as its photospheric disk expands behind the dust screen. We find for a small percentage of SNe the AV and RV values can vary by a large factor from day to day in the first 40 days after explosion.

  13. Solution hardening and strain hardening at elevated temperatures

    International Nuclear Information System (INIS)

    Kocks, U.F.

    1982-10-01

    Solutes can significantly increase the rate of strain hardening; as a consequence, the saturation stress, at which strain hardening tends to cease for a given temperature and strain rate, is increased more than the yield stress: this is the major effect of solutes on strength at elevated temperatures, especially in the regime where dynamic strain-aging occurs. It is shown that local solute mobility can affect both the rate of dynamic recovery and the dislocation/dislocation interaction strength. The latter effect leads to multiplicative solution strengthening. It is explained by a new model based on repeated dislocation unlocking, in a high-temperature limit, which also rationalizes the stress dependence of static and dynamic strain-aging, and may help explain the plateau of the yield stress at elevated temperatures. 15 figures

  14. Technology of hardening fills for mined spaces

    International Nuclear Information System (INIS)

    Simek, P.; Holas, M.; Chyla, A.; Pech, P.

    1985-01-01

    The technology is described of hardening fills for mined spaces of uranium deposits in North Bohemian chalk. A special equipment was developed for the controlled preparation of a hardening mixture. The composition of the fill is determined by the strength of the filled rock, expecially by the standard strength, i.e., the minimal strength of the filling under uniaxial pressure. The said parameter determines the consumption of binding materials and thereby the total costs of the filling. A description is presented of the filling technology, including rabbit tube transport of the mixture and quality control. (Pu)

  15. Estimation of radiation hardening in ferritic steels using the cluster dynamics models

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Jun Hyun; Kim, Whung Whoe; Hong, Jun Hwa [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    2005-07-01

    Evolution of microstructure under irradiation brings about the mechanical property changes of materials, of which the major concern is radiation hardening in this work. Radiation hardening is generally expressed in terms of an increase in yield strength as a function of radiation dose and temperature. Cluster dynamics model for radiation hardening has been developed to describe the evolution of point defects clusters (PDCs) and copperrich precipitates (CRPs). While the mathematical models developed by Stoller focus on the evolution of PDCs in ferritic steels under neutron irradiation, we slightly modify the model by including the CRP growth and estimate the magnitude of hardening induced by PDC and CRP. The model is then used to calculate the changes in yield strength of RPV steels. The calculation results are compared to measured yield strength values, obtained from surveillance testing of PWR vessel steels in France.

  16. Oligomeric stability of Rapana venosa hemocyanin (RvH) and its structural subunits.

    Science.gov (United States)

    Dolashka-Angelova, Pavlina; Schwarz, Heinz; Dolashki, Aleksandar; Stevanovic, Stefan; Fecker, Miriam; Saeed, Muhammad; Voelter, Wolfgang

    2003-03-21

    The two structural subunits RvH1 and RvH2 were separated after overnight dialysis of Rapana venosa Hc against 130 mM Gly/NaOH buffer, pH 9.6, on an ion exchange column Hiload 26/10 Sepharose Q using a fast performance liquid chromatography (FPLC) system. The reassociation characteristics of these two RvH isoforms and the native molecule were studied in buffers with different pH values and concentrations of Ca(2+) and Mg(2+). Reassociation of mixed RvH subunits was performed over a period of several days using a stabilizing buffer (SB) of pH 7.0 containing different concentrations of Ca(2+) and Mg(2+) ions. After 2 days of dialysis, an RvH subunit mixture of didecamers and multidecamers was observed in the presence of 100 mM CaCl(2) and MgCl(2), though RvH1 and RvH2 are biochemically and immunologically different and have also different dissociation properties. The reassociation, performed at pH 9.6 with 2 mM CaCl(2) and MgCl(2) at 4 degrees C over a period of one to several weeks, led to the formation of decameric oligomers, while didecamers formed predominantly in the SB at pH 7.0. Higher concentrations of calcium and magnesium ions led to a more rapid reassociation of RvH1 resulting in long stable multidecamers and helical tubules, which were stable and slowly dissociated into shorter multidecamers and decamers at higher pH values. The reassociation of the RvH2 structural subunit in the same buffers processed slowly and yielded didecamers, shorter tubule polymers and long multidecamers which are less stable at higher pH values. The stability of RvH isoforms under varying ionic conditions is compared with the stability of keyhole limpet (KLH, Megathura crenulata) hemocyanin (KLH) and Haliotis tuberculata hemocyanin (HtH) isoforms. The process of dissociation and reassociation is connected with changes of the fluorescence intensity at 600 nm, which can be explained by differences in opalescence of the solutions of these two isoforms. The solutions of longer tubule

  17. Work hardening correlation for monotonic loading based on state variables

    International Nuclear Information System (INIS)

    Huang, F.H.; Li, C.Y.

    1977-01-01

    An absolute work hardening correlation in terms of the hardness parameter and the internal stress based on the state variable approach was developed. It was found applicable to a variety of metals and alloys. This correlation predicts strain rate insensitive work hardening properties at low homologous temperatures and produces strain rate effects at higher homologous temperatures without involving thermally induced recovery processes

  18. Synthesis of a new hardener agent for self-healing epoxy resins

    Science.gov (United States)

    Raimondo, Marialuigia; Guadagno, Liberata; Naddeo, Carlo; Longo, Pasquale; Mariconda, Annaluisa; Agovino, Anna

    2014-05-01

    Actually, the development of smart composites capable of self-repair in aeronautical structures is still at the planning stage owing to complex issues to overcome. One of the critical points in the development of self-healing epoxy resin is related to the impossibility to employ primary amines as hardeners. In this paper, the synthesis of a new hardener for self-healing resins is shown together with applicability conditions/ranges.

  19. A unified theoretical and experimental study of anisotropic hardening

    International Nuclear Information System (INIS)

    Boehler, J.P.; Raclin, J.

    1981-01-01

    The purpose of this work is to develop a consistent formulation of the constitutive relations regarding anisotropic hardening materials. Attention is focused on the appearance and the evolution of mechanical anisotropies during irreversible processes, such as plastic forming and inelastic deformation of structures. The representation theorems for anisotropic tensor functions constitute a theoretical basis, allowing to reduce arbitrariness and to obtain a unified formulation of anisotropic hardening. In this approach, a general three-dimensional constitutive law is developed for prestrained initially orthotropic materials. Introduction of the plastic behavior results in the general forms of both the flow-law and the yield criterion. The developed theory is then specialized for the case of plane stress and different modes of anisotropic hardening are analyzed. A new generalization of the Von Mises criterion is proposed, in considering a homogeneous form of order two in stress and employing the simplest combinations of the basic invariants entering the general form of the yield condition. The proposed criterion involves specific terms accounting for the initial anisotropy, the deformation induced anisotropy and correlative terms between initial and induced anisotropy. The effects of prestrainings result in both isotropic and anisotropic hardening. An adequate experimental program, consisting of uniaxial tensile tests on oriented specimens of prestrained sheet-metal, was performed, in order to determine the specific form and the evolution of the anisotropic failure criterion for soft-steel subjected to different irreversible prestrainings. (orig.)

  20. Development of a wood-polymer composite by electron beam hardening

    International Nuclear Information System (INIS)

    Gotoda, Masao

    1974-01-01

    An incombustible wood-polymer composite (WPC) was studied. The dimensional stability was also tested. The comparison of conversion ratio was made between gamma-ray and electron beam and between a vinylidene chloride 100% impregnated beech composite and bulk. In the case of gamma-ray of low dose rate, the conversion ratio in the vinylidene chloride beech composite was lower than the bulk. In the case of electron beam, though dose rate was higher than that of gamma-ray, the conversion ratio was low, and was influenced by the moisture content of wood. The conversion ratio markedly decreased with the increase of the dose rate of electron beam. Roughly 50% polymer loading can be obtained when the dose rate of electron beam is low. In the case of gamma-ray, the effect of dimensional stability was approximately none with small polymer loading, whereas in the case of electron beam irradiation of moist wood, marked effect of dimensional stability was shown. Incombustibility effect was tested by burning a 150 mm long piece, in which three small pieces of 5 x 10 x 50 mm were connected with epoxy resin adhesive, with a Bunsen burner for 30 seconds. After the completion of burning, the long piece was separated back into three small pieces, and the char length, weight loss and after glow time were tested. The beech composite was expected to become incombustible at 40% polymer loading. The vinyl monomer solution of chlorinated aryl chloride oligomer can be easily hardened by electron beam irradiation. Addition of crosslinking agent such as trimethylol propane trimethracrylate prevents the dissolution of hardened methyl acrylate and methyl methacrylate by acetone. The electron beam hardening of aryl resin compound is possible, using benzen peroxide as a catalyst. Floor material can be produced by this process from low density, low price wood. (Iwakiri, K.)

  1. Hydrogen embrittlement susceptibility of laser-hardened 4140 steel

    Energy Technology Data Exchange (ETDEWEB)

    Tsay, L.W.; Lin, Z.W. [Nat. Taiwan Ocean Univ., Keelung (Taiwan). Inst. of Mater. Eng.; Shiue, R.K. [Institute of Materials Sciences and Engineering, National Dong Hwa University, Hualien, Taiwan (Taiwan); Chen, C. [Institute of Materials Sciences and Engineering, National Taiwan University, Taipei, Taiwan (Taiwan)

    2000-10-15

    Slow strain rate tensile (SSRT) tests were performed to investigate the susceptibility to hydrogen embrittlement of laser-hardened AISI 4140 specimens in air, gaseous hydrogen and saturated H{sub 2}S solution. Experimental results indicated that round bar specimens with two parallel hardened bands on opposite sides along the loading axis (i.e. the PH specimens), exhibited a huge reduction in tensile ductility for all test environments. While circular-hardened (CH) specimens with 1 mm hardened depth and 6 mm wide within the gauge length were resistant to gaseous hydrogen embrittlement. However, fully hardened CH specimens became susceptible to hydrogen embrittlement for testing in air at a lower strain rate. The strength of CH specimens increased with decreasing the depth of hardened zones in a saturated H{sub 2}S solution. The premature failure of hardened zones in a susceptible environment caused the formation of brittle intergranular fracture and the decrease in tensile ductility. (orig.)

  2. Rv0004 is a new essential member of the mycobacterial DNA replication machinery.

    Science.gov (United States)

    Mann, Katherine M; Huang, Deborah L; Hooppaw, Anna J; Logsdon, Michelle M; Richardson, Kirill; Lee, Hark Joon; Kimmey, Jacqueline M; Aldridge, Bree B; Stallings, Christina L

    2017-11-01

    DNA replication is fundamental for life, yet a detailed understanding of bacterial DNA replication is limited outside the organisms Escherichia coli and Bacillus subtilis. Many bacteria, including mycobacteria, encode no identified homologs of helicase loaders or regulators of the initiator protein DnaA, despite these factors being essential for DNA replication in E. coli and B. subtilis. In this study we discover that a previously uncharacterized protein, Rv0004, from the human pathogen Mycobacterium tuberculosis is essential for bacterial viability and that depletion of Rv0004 leads to a block in cell cycle progression. Using a combination of genetic and biochemical approaches, we found that Rv0004 has a role in DNA replication, interacts with DNA and the replicative helicase DnaB, and affects DnaB-DnaA complex formation. We also identify a conserved domain in Rv0004 that is predicted to structurally resemble the N-terminal protein-protein interaction domain of DnaA. Mutation of a single conserved tryptophan within Rv0004's DnaA N-terminal-like domain leads to phenotypes similar to those observed upon Rv0004 depletion and can affect the association of Rv0004 with DnaB. In addition, using live cell imaging during depletion of Rv0004, we have uncovered a previously unappreciated role for DNA replication in coordinating mycobacterial cell division and cell size. Together, our data support that Rv0004 encodes a homolog of the recently identified DciA family of proteins found in most bacteria that lack the DnaC-DnaI helicase loaders in E. coli and B. subtilis. Therefore, the mechanisms of Rv0004 elucidated here likely apply to other DciA homologs and reveal insight into the diversity of bacterial strategies in even the most conserved biological processes.

  3. Rv3634c from Mycobacterium tuberculosis H37Rv encodes an enzyme with UDP-Gal/Glc and UDP-GalNAc 4-epimerase activities.

    Directory of Open Access Journals (Sweden)

    Peehu Pardeshi

    Full Text Available A bioinformatics study revealed that Mycobacterium tuberculosis H37Rv (Mtb contains sequence homologs of Campylobacter jejuni protein glycosylation enzymes. The ORF Rv3634c from Mtb was identified as a sequence homolog of C. jejuni UDP-Gal/GalNAc 4-epimerase. This study reports the cloning of Rv3634c and its expression as an N-terminal His-tagged protein. The recombinant protein was shown to have UDP-Gal/Glc 4-epimerase activity by GOD-POD assay and by reverse phase HPLC. This enzyme was shown to have UDP-GalNAc 4-epimerase activity also. Residues Ser121, Tyr146 and Lys150 were shown by site-directed mutagenesis to be important for enzyme activity. Mutation of Ser121 and Tyr146 to Ala and Phe, respectively, led to complete loss of activity whereas mutation of Lys150 to Arg led to partial loss of activity. There were no gross changes in the secondary structures of any of these three mutants. These results suggest that Ser121 and Tyr146 are essential for epimerase activity of Rv3634c. UDP-Gal/Glc 4-epimerases from other organisms also have a catalytic triad consisting of Ser, Tyr and Lys. The triad carries out proton transfer from nucleotide sugar to NAD+ and back, thus effecting the epimerization of the substrate. Addition of NAD+ to Lys150 significantly abrogates the loss of activity, suggesting that, as in other epimerases, NAD+ is associated with Rv3634c.

  4. Characterization of the work hardening structure of austenitic steels by X-ray diffraction. Application to the determination of work hardening gradients and the study of recovery

    International Nuclear Information System (INIS)

    Cadalbert, Robert; Baron, J.L.

    1977-01-01

    A method has been developed to determine quantitatively the work hardening of austenitic steels by measurement of the broadening of X-ray diffraction lines. This simple, rapid, accurate and sensible method enables to determine work hardening variations in the thickness of a material. The complete automation of the measurement cycle using a small computer enables to carry out numerous determinations and to process data with accuracy. The unit developed is well adapted to the testing of metallic materials. It is also possible with this method to study the evolution of work hardening in a metal as a function of heat treatments. For instance, the determination of the recovery curves of the crystal lattice in austenitic steels allows to investigate the influence of additions (Mo, Ti) on the recovery kinetics [fr

  5. Challenges in hardening technologies using shallow-trench isolation

    International Nuclear Information System (INIS)

    Shaneyfelt, M.R.; Dodd, P.E.; Draper, B.L.; Flores, R.S.

    1998-02-01

    Challenges related to radiation hardening CMOS technologies with shallow-trench isolation are explored. Results show that trench hardening can be more difficult than simply replacing the trench isolation oxide with a hardened field oxide

  6. Nuclear effects hardened shelters

    International Nuclear Information System (INIS)

    Lindke, P.

    1990-01-01

    This paper reports on the Houston Fearless 76 Government Projects Group that has been actively engaged for more than twenty-five years as a sub-contractor and currently as a prime contractor in the design, manufacture, repair and logistics support of custom mobile ground stations and their equipment accommodations. Other associated products include environmental control units (ECU's), mobilizers for shelters and a variety of mobile power generation units (MPU's). Since 1984, Houston Fearless 76 has designed and manufactured four 8 foot by 8 foot x 22 foot nuclear hardened mobile shelters. These shelters were designed to contain electronic data processing/reduction equipment. One shelter is currently being operated by the Air Force as a Defense Intelligence Agency (DIA) approved and certified Special Compartmented Information Facility (SCIF). During the development and manufacturing process of the shelters, we received continual technical assistance and design concept evaluations from Science Applications International Corporation (SAIC) Operations Analysis and Logistics Engineering Division and the Nondestructive Inspection Lab at McClellan AFB. SAIC was originally employed by the Air Force to design the nuclear hardening specifications applied to these shelters

  7. On residual stresses and fatigue of laser hardened steels

    International Nuclear Information System (INIS)

    Lin, Ru.

    1992-01-01

    This thesis deals with studies on residual stresses and fatigue properties of laser-transformation hardened steels. Two types of specimens, cylinders and fatigue specimens were used in the studies. The cylinders, made of Swedish steels SS 2244 and SS 2258 which correspond to AISI 4140 and AISI 52100 respectively, were locally hardened by a single scan of laser beam in the longitudinal direction, with various laser parameters. Residual stress distributions across the hardened tracks were measured by means of X-ray diffraction. The origins of residual stresses were investigated and discussed. For the fatigue specimens, including smooth and notched types made of Swedish steels SS 2244, SS 2225 and SS 1572 (similar to AISI 4140, AISI 4130 and AISI 1035, respectively), laser hardening was carried out in the gauge section. The residual stress field induced by the hardening process and the fatigue properties by plane bending fatigue test were studied. In order to investigate the stability of the residual stress field, stress measurements were also made on specimens being loaded near the fatigue limits for over 10 7 cycles. Further the concept of local fatigue strength was employed to correlate quantitatively the effect of hardness and residual stress field on the fatigue limits. In addition a group of smooth specimens of SS 2244 was induction hardened and the hardening results were compared with the corresponding laser hardened ones in terms of residual stress and fatigue behaviour. It has been found that compressive stresses exist in the hardened zone of all the specimens studied. The laser hardening condition, the specimen and how the hardening is carried out can significantly affect the residual stress field. Laser hardening can greatly improve the fatigue properties by inducing a hardened and compressed surface layer. (112 refs.)(au)

  8. On residual stresses and fatigue of laser hardened steels

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Ru.

    1992-01-01

    This thesis deals with studies on residual stresses and fatigue properties of laser-transformation hardened steels. Two types of specimens, cylinders and fatigue specimens were used in the studies. The cylinders, made of Swedish steels SS 2244 and SS 2258 which correspond to AISI 4140 and AISI 52100 respectively, were locally hardened by a single scan of laser beam in the longitudinal direction, with various laser parameters. Residual stress distributions across the hardened tracks were measured by means of X-ray diffraction. The origins of residual stresses were investigated and discussed. For the fatigue specimens, including smooth and notched types made of Swedish steels SS 2244, SS 2225 and SS 1572 (similar to AISI 4140, AISI 4130 and AISI 1035, respectively), laser hardening was carried out in the gauge section. The residual stress field induced by the hardening process and the fatigue properties by plane bending fatigue test were studied. In order to investigate the stability of the residual stress field, stress measurements were also made on specimens being loaded near the fatigue limits for over 10[sup 7] cycles. Further the concept of local fatigue strength was employed to correlate quantitatively the effect of hardness and residual stress field on the fatigue limits. In addition a group of smooth specimens of SS 2244 was induction hardened and the hardening results were compared with the corresponding laser hardened ones in terms of residual stress and fatigue behaviour. It has been found that compressive stresses exist in the hardened zone of all the specimens studied. The laser hardening condition, the specimen and how the hardening is carried out can significantly affect the residual stress field. Laser hardening can greatly improve the fatigue properties by inducing a hardened and compressed surface layer. (112 refs.)(au).

  9. rvær i pædagogisk praksis

    DEFF Research Database (Denmark)

    rvær i pædagogisk praksis handler om, hvordan lærere og pædagoger kan arbejde med mindfulness i skole og daginstitution. Målet er at give inspiration til, hvordan man kan skabe et lærings- og udviklingsmiljø, som understøtter en praksis, hvor børn får erfaringer med at være til stede i sig selv......, ligesom de giver eksempler på nærværende kunst- og musikundervisning.   Den røde tråd er ønsket om at bistå barnet i at rumme sig selv og andre og en interesse for de muligheder, som øget nærvær kan give det enkelte barn og fællesskabet....

  10. Radiation-hardened CMOS/SOS LSI circuits

    International Nuclear Information System (INIS)

    Aubuchon, K.G.; Peterson, H.T.; Shumake, D.P.

    1976-01-01

    The recently developed technology for building radiation-hardened CMOS/SOS devices has now been applied to the fabrication of LSI circuits. This paper describes and presents results on three different circuits: an 8-bit adder/subtractor (Al gate), a 256-bit shift register (Si gate), and a polycode generator (Al gate). The 256-bit shift register shows very little degradation after 1 x 10 6 rads (Si), with an increase from 1.9V to 2.9V in minimum operating voltage, a decrease of about 20% in maximum frequency, and little or no change in quiescent current. The p-channel thresholds increase from -0.9V to -1.3V, while the n-channel thresholds decrease from 1.05 to 0.23V, and the n-channel leakage remains below 1nA/mil. Excellent hardening results were also obtained on the polycode generator circuit. Ten circuits were irradiated to 1 x 10 6 rads (Si), and all continued to function well, with an increase in minimum power supply voltage from 2.85V to 5.85V and an increase in quiescent current by a factor of about 2. Similar hardening results were obtained on the 8-bit adder, with the minimum power supply voltage increasing from 2.2V to 4.6V and the add time increasing from 270 to 350 nsec after 1 x 10 6 rads (Si). These results show that large CMOS/SOS circuits can be hardened to above 1 x 10 6 rads (Si) with either the Si gate or Al gate technology. The paper also discusses the relative advantages of the Si gate versus the Al gate technology

  11. Changes in right ventricular function assessed by echocardiography in dog models of mild RV pressure overload.

    Science.gov (United States)

    Morita, Tomoya; Nakamura, Kensuke; Osuga, Tatsuyuki; Yokoyama, Nozomu; Morishita, Keitaro; Sasaki, Noboru; Ohta, Hiroshi; Takiguchi, Mitsuyoshi

    2017-07-01

    The assessment of hemodynamic change by echocardiography is clinically useful in patients with pulmonary hypertension. Recently, mild elevation of the mean pulmonary arterial pressure (PAP) has been shown to be associated with increased mortality. However, changes in the echocardiographic indices of right ventricular (RV) function are still unknown. The objective of this study was to validate the relationship between echocardiographic indices of RV function and right heart catheterization variables under a mild RV pressure overload condition. Echocardiography and right heart catheterization were performed in dog models of mild RV pressure overload induced by thromboxane A 2 analog (U46619) (n=7). The mean PAP was mildly increased (19.3±1.1 mm Hg), and the cardiac index was decreased. Most echocardiographic indices of RV function were significantly impaired even under a mild RV pressure overload condition. Multivariate analysis revealed that the RV free wall longitudinal strain (RVLS), standard deviation of the time-to-peak longitudinal strain of RV six segments (RV-SD) by speckle-tracking echocardiography, and Tei index were independent echocardiographic predictors of the mean PAP (free wall RVLS, β=-0.60, P<.001; RV-SD, β=0.40, P=.011), pulmonary vascular resistance (free wall RVLS, β=-0.39, P=.020; RV-SD, β=0.47, P=.0086; Tei index, β=0.34, P=.047), and cardiac index (Tei index, β=-0.65, P<.001). Free wall RVLS, RV-SD, and Tei index are useful for assessing the hemodynamic change under a mild RV pressure overload condition. © 2017, Wiley Periodicals, Inc.

  12. Laser Surface Hardening of Groove Edges

    Science.gov (United States)

    Hussain, A.; Hamdani, A. H.; Akhter, R.; Aslam, M.

    2013-06-01

    Surface hardening of groove-edges made of 3Cr13 Stainless Steel has been carried out using 500 W CO2 laser with a rectangular beam of 2.5×3 mm2. The processing speed was varied from 150-500 mm/min. It was seen that the hardened depth increases with increase in laser interaction time. A maximum hardened depth of around 1mm was achieved. The microhardness of the transformed zone was 2.5 times the hardness of base metal. The XRD's and microstructural analysis were also reported.

  13. Archive of Digitized Analog Boomer and Minisparker Seismic Reflection Data Collected from the Alabama-Mississippi-Louisiana Shelf During Cruises Onboard the R/V Carancahua and R/V Gyre, April and July, 1981

    Science.gov (United States)

    Sanford, Jordan M.; Harrison, Arnell S.; Wiese, Dana S.; Flocks, James G.

    2009-01-01

    In April and July of 1981, the U.S. Geological Survey (USGS) conducted geophysical surveys to investigate the shallow geologic framework of the Alabama-Mississippi-Louisiana Shelf in the northern Gulf of Mexico. Work was conducted onboard the Texas A&M University R/V Carancahua and the R/V Gyre to develop a geologic understanding of the study area and to locate potential hazards related to offshore oil and gas production. While the R/V Carancahua only collected boomer data, the R/V Gyre used a 400-Joule minisparker, 3.5-kilohertz (kHz) subbottom profiler, 12-kHz precision depth recorder, and two air guns. The authors selected the minisparker data set because, unlike with the boomer data, it provided the most complete record. This report is part of a series to digitally archive the legacy analog data collected from the Mississippi-Alabama SHelf (MASH). The MASH data rescue project is a cooperative effort by the USGS and the Minerals Management Service (MMS). This report serves as an archive of high-resolution scanned Tagged Image File Format (TIFF) and Graphics Interchange Format (GIF) images of the original boomer and minisparker paper records, navigation files, trackline maps, Geographic Information System (GIS) files, cruise logs, and formal Federal Geographic Data Committee (FGDC) metadata.

  14. The method of modelling of relationships between hardenability and chemical composition of the constructional alloy steels

    International Nuclear Information System (INIS)

    Dobrzanski, L.A.; Sitek, W.

    1998-01-01

    Basing on the experimental results of the hardenability investigations, which employed Jominy method, the model of the neural networks was developed and fully verified experimentally. The model makes it possible to obtain Jominy hardenability curves basing on the steel chemical composition. The model of neural networks, making it possible to design the steel chemical composition, basing on the known Jominy hardenability curve shape, was developed also and fully verified numerically. The practical usability of the models developed is presented. (author)

  15. Hydrochemical data from R/V MIKHAIL LOMONSOV and R/V AKADEMIK VERNADSKIY in the Indian Ocean from 16 May 1966 to 01 October 1981 (NODC Accession 0000277)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hydrochemical data were collected from R/V MIKHAIL LOMONSOV and R/V AKADEMIK VERNADSKIY in the Indian Ocean from 16 May 1966 to 01 October 1981. Data were collected...

  16. Mycobacterium tuberculosislpdC, Rv0462, induces dendritic cell maturation and Th1 polarization

    Energy Technology Data Exchange (ETDEWEB)

    Heo, Deok Rim [Department of Microbiology and Immunology, School of Medicine, Pusan National University, Beom-eo Ri, Mulgum Eop, Yangsan, Gyeongsangnam-do 626-770 (Korea, Republic of); Shin, Sung Jae; Kim, Woo Sik [Department of Microbiology, College of Medicine, Chungnam National University, Munwha-Dong, Jung-Ku, Daejeon 301-747 (Korea, Republic of); Noh, Kyung Tae; Park, Jin Wook; Son, Kwang Hee [Department of Microbiology and Immunology, School of Medicine, Pusan National University, Beom-eo Ri, Mulgum Eop, Yangsan, Gyeongsangnam-do 626-770 (Korea, Republic of); Park, Won Sun [Department of Physiology, Kangwon National University, School of Medicine, Chuncheon 200-701 (Korea, Republic of); Lee, Min-Goo [Department of Physiology, Korea University, College of Medicine, Anam-dong, Sungbuk-Gu, Seoul 136-705 (Korea, Republic of); Kim, Daejin [Department of Anatomy, Chung-Ang University, College of Medicine, 221 Heuksuk-Dong, Dongjak-Ku, Seoul 156-756 (Korea, Republic of); Shin, Yong Kyoo [Department of Pharmacology, Chung-Ang University, College of Medicine, 221 Heuksuk-Dong, Dongjak-Ku, Seoul 156-756 (Korea, Republic of); Jung, In Duk, E-mail: jungid@pusan.ac.kr [Department of Microbiology and Immunology, School of Medicine, Pusan National University, Beom-eo Ri, Mulgum Eop, Yangsan, Gyeongsangnam-do 626-770 (Korea, Republic of); Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Beom-eo Ri, Mulgum Eop, Yangsan, Gyeongsangnam-do 626-770 (Korea, Republic of); Park, Yeong-Min, E-mail: immunpym@pusan.ac.kr [Department of Microbiology and Immunology, School of Medicine, Pusan National University, Beom-eo Ri, Mulgum Eop, Yangsan, Gyeongsangnam-do 626-770 (Korea, Republic of); Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Beom-eo Ri, Mulgum Eop, Yangsan, Gyeongsangnam-do 626-770 (Korea, Republic of)

    2011-08-05

    Highlights: {yields} Treatment with Rv0462 induces the expression of surface molecules and the production of cytokines in DCs. {yields} Rv0462 induces the activation of MAPKs. {yields} Rv0462-treated DCs enhances the proliferation of CD4{sup +} T cells. -- Abstract: Mycobacterium tuberculosis, the etiological factor of pulmonary tuberculosis, causes significant morbidity and mortality worldwide. Activation of host immune responses for containment of mycobacterial infections involves participation of innate immune cells, such as dendritic cells (DCs). In this study, we demonstrated that the gene encoding lipoamide dehydrogenase C (lpdC) from M. tuberculosis, Rv0462, induce maturation and activation of DCs involved in the MAPKs signaling pathway. Moreover, Rv0462-treated DCs activated naive T cells, polarized CD4{sup +} and CD8{sup +} T cells to secrete IFN-{gamma} in syngeneic mixed lymphocyte reactions, which would be expected to contribute to Th1 polarization of the immune response. Our results suggest that Rv0462 can contribute to the innate and adaptive immune responses during tuberculosis infection, and thus modulate the clinical course of tuberculosis.

  17. Mycobacterium tuberculosislpdC, Rv0462, induces dendritic cell maturation and Th1 polarization

    International Nuclear Information System (INIS)

    Heo, Deok Rim; Shin, Sung Jae; Kim, Woo Sik; Noh, Kyung Tae; Park, Jin Wook; Son, Kwang Hee; Park, Won Sun; Lee, Min-Goo; Kim, Daejin; Shin, Yong Kyoo; Jung, In Duk; Park, Yeong-Min

    2011-01-01

    Highlights: → Treatment with Rv0462 induces the expression of surface molecules and the production of cytokines in DCs. → Rv0462 induces the activation of MAPKs. → Rv0462-treated DCs enhances the proliferation of CD4 + T cells. -- Abstract: Mycobacterium tuberculosis, the etiological factor of pulmonary tuberculosis, causes significant morbidity and mortality worldwide. Activation of host immune responses for containment of mycobacterial infections involves participation of innate immune cells, such as dendritic cells (DCs). In this study, we demonstrated that the gene encoding lipoamide dehydrogenase C (lpdC) from M. tuberculosis, Rv0462, induce maturation and activation of DCs involved in the MAPKs signaling pathway. Moreover, Rv0462-treated DCs activated naive T cells, polarized CD4 + and CD8 + T cells to secrete IFN-γ in syngeneic mixed lymphocyte reactions, which would be expected to contribute to Th1 polarization of the immune response. Our results suggest that Rv0462 can contribute to the innate and adaptive immune responses during tuberculosis infection, and thus modulate the clinical course of tuberculosis.

  18. Hardening Embrittlement and Non-Hardening Embrittlement of Welding-Heat-Affected Zones in a Cr-Mo Low Alloy Steel

    Directory of Open Access Journals (Sweden)

    Yu Zhao

    2018-06-01

    Full Text Available The embrittlement of heat affected zones (HAZs resulting from the welding of a P-doped 2.25Cr-1Mo steel was studied by the analysis of the fracture appearance transition temperatures (FATTs of the HAZs simulated under a heat input of 45 kJ/cm with different peak temperatures. The FATTs of the HAZs both with and without tempering increased with the rise of the peak temperature. However, the FATTs were apparently lower for the tempered HAZs. For the as-welded (untempered HAZs, the FATTs were mainly affected by residual stress, martensite/austenite (M/A islands, and bainite morphology. The observed embrittlement is a hardening embrittlement. On the other hand, the FATTs of the tempered HAZs were mainly affected by phosphorus grain boundary segregation, thereby causing a non-hardening embrittlement. The results demonstrate that the hardening embrittlement of the as-welded HAZs was more severe than the non-hardening embrittlement of the tempered HAZs. Consequently, a post-weld heat treatment should be carried out if possible so as to eliminate the hardening embrittlement.

  19. Which is the better forecasting model? A comparison between HAR-RV and multifractality volatility

    Science.gov (United States)

    Ma, Feng; Wei, Yu; Huang, Dengshi; Chen, Yixiang

    2014-07-01

    In this paper, by taking the 5-min high frequency data of the Shanghai Composite Index as example, we compare the forecasting performance of HAR-RV and Multifractal volatility, Realized volatility, Realized Bipower Variation and their corresponding short memory model with rolling windows forecasting method and the Model Confidence Set which is proved superior to SPA test. The empirical results show that, for six loss functions, HAR-RV outperforms other models. Moreover, to make the conclusions more precise and robust, we use the MCS test to compare the performance of their logarithms form models, and find that the HAR-log(RV) has a better performance in predicting future volatility. Furthermore, by comparing the two models of HAR-RV and HAR-log(RV), we conclude that, in terms of performance forecasting, the HAR-log(RV) model is the best model among models we have discussed in this paper.

  20. Radiation-chemical hardening of phenol-formaldehyde oligomers

    International Nuclear Information System (INIS)

    Shlapatskaya, V.V.; Omel'chenko, S.I.

    1978-01-01

    Radiation-chemical hardening of phenol formaldehyde oligomers of the resol type has been studied in the presence of furfural and diallylphthalate diluents. The samples have been hardened on an electron accelerator at an electron energy of 1.0-1.1 MeV and a dose rate of 2-3 Mrad/s. The kinetics of hardening has been studied on the yield of gel fraction within the range of absorbed doses from 7 to 400 Mrad. Radiation-chemical hardening of the studied compositions is activated with sensitizers, namely, amines, metal chlorides, and heterocyclic derivatives of metals. Furfural and diallylphthalate compositions are suitable for forming glass-fibre plastic items by the wet method and coatings under the action of ionizing radiations

  1. Bake hardening of nanograin AA7075 aluminum alloy

    International Nuclear Information System (INIS)

    Dehghani, Kamran

    2011-01-01

    Highlights: ► The bake hardening behavior of AA7075 was studied and compared with its coarse-grain counterpart. ► Nanograin AA7075 exhibited 88–100% increase in bake hardenability. ► Nanograin AA7075 exhibited 36–38% increase in final yield strength after baking. ► Maximum bake hardenability and final yield stress were about 185 MPa and 719 MPa. - Abstract: In the present work, the bake hardening of nanostructured AA7075 aluminum alloy was compared with that of its coarse-grain counterpart. Surface severe plastic deformation (SSPD) was used to produce nanograin layers on both surfaces of workpieces. The nanostructured layers were characterized using scanning electron microscopy (SEM) and atomic force microscopy (AFM) techniques. The thickness of nanostructured layer, having the grains of 50–110 nm, was about 75 μm on each side of workpiece. The bake hardenability of nanograin and coarse-grain AA7075 was then compared by pre-straining to 2, 4 and 6% followed by baking at 100 °C and 200 °C for 20 min. Comparing to coarse-grain case, there was about 88–100% increase in bake hardenability and about 36–38% increase in yield strength after the bake hardening of present nanograin AA7075. Such an increase in bake hardenability and strength was achieved when the thickness of two nanograin layers was about only one-tenth of the whole thickness.

  2. Structural heredity influence upon principles of strain wave hardening

    Science.gov (United States)

    Kiricheck, A. V.; Barinov, S. V.; Yashin, A. V.

    2017-02-01

    It was established experimentally that by penetration of a strain wave through material hardened not only the technological modes of processing, but also a technological heredity - the direction of the fibers of the original macrostructure have an influence upon the diagram of microhardness. By penetration of the strain wave along fibers, the degree of hardening the material is less, however, a product is hardened throughout its entire section mainly along fibers. In the direction of the strain waves across fibers of the original structure of material, the degree of material hardening is much higher, the depth of the hardened layer with the degree of hardening not less than 50% makes at least 3 mm. It was found that under certain conditions the strain wave can completely change the original structure of the material. Thus, a heterogeneously hardened structure characterized by the interchange of harder and more viscous areas is formed, which is beneficial for assurance of high operational properties of material.

  3. Thermomechanical properties of radiation hardened oligoesteracrylates

    International Nuclear Information System (INIS)

    Lomonosova, N.V.; Chikin, Yu.A.

    1984-01-01

    Thermomechanical properties of radiation hardened oligoesteracrylates are studied by the methods of isothermal heating and thermal mechanics. Films of dimethacrylate of ethylene glycol, triethylene glycol (TGM-3), tetraethylene glycol, tridecaethylene glycol and TGM-3 mixture with methyl methacrylate hardened by different doses (5-150 kGy) using Co 60 installation with a dose rate of 2x10 -3 kGy/s served as a subject of the research. During oligoesteracrylate hargening a space network is formed, chain sections between lattice points of which are in a stressed state. Maximum of deformation is observed at 210-220 deg C on thermomechanical curves of samples hardened by doses > 5 kGy, which form and intensity is dependent on an absorbed dose. Presence of a high-temperature maximum on diaqrams of isometric heating of spatially cross-linked oligoesteracrylates is discovered. High thermal stability of three-dimensional network of radiation hardened oligoesteracrylates provides satisfactory tensile properties (40% of initial strength) in sample testing an elevated temperatures (200-250 deg C)

  4. Radiation-hardened micro-electronics for nuclear instrumentation

    International Nuclear Information System (INIS)

    Van Uffelen, M.

    2007-01-01

    The successful development and deployment of future fission and thermonuclear fusion reactors depends to a large extent on the advances of different enabling technologies. Not only the materials need to be custom engineered but also the instrumentation, the electronics and the communication equipment need to support operation in this harsh environment, with expected radiation levels during maintenance up to several MGy. Indeed, there are yet no commercially available electronic devices available off-the-shelf which demonstrated a satisfying operation at these extremely high radiation levels. The main goal of this task is to identify commercially available radiation tolerant technologies, and to design dedicated and integrated electronic circuits, using radiation hardening techniques, both at the topological and architectural level. Within a stepwise approach, we first design circuits with discrete components and look for an equivalent integrated technology. This will enable us to develop innovative instrumentation and communication tools for the next generation of nuclear reactors, where both radiation hardening and miniaturization play a dominant role

  5. Instabilities in power law gradient hardening materials

    DEFF Research Database (Denmark)

    Niordson, Christian Frithiof; Tvergaard, Viggo

    2005-01-01

    Tension and compression instabilities are investigated for specimens with dimensions in the micron range. A finite strain generalization of a higher order strain gradient plasticity theory is implemented in a finite element scheme capable of modeling power law hardening materials. Effects...... of gradient hardening are found to delay the onset of localization under plane strain tension, and significantly reduce strain gradients in the localized zone. For plane strain compression gradient hardening is found to increase the load-carrying capacity significantly....

  6. Skin hardening effect in patients with polymorphic light eruption: comparison of UVB hardening in hospital with a novel home UV-hardening device.

    Science.gov (United States)

    Franken, S M; Genders, R E; de Gruijl, F R; Rustemeyer, T; Pavel, S

    2013-01-01

    An effective prophylactic treatment of patients with polymorphic light eruption (PLE) consists of repeated low, gradually increasing exposures to UVB radiation. This so-called UV(B) hardening induces better tolerance of the skin to sunlight. SunshowerMedical company (Amsterdam) has developed an UV (B) source that can be used during taking shower. The low UV fluence of this apparatus makes it an interesting device for UV hardening. In a group of PLE patients, we compared the effectiveness of the irradiation with SunshowerMedical at home with that of the UVB treatment in the hospital. The PLE patients were randomized for one of the treatments. The hospital treatment consisted of irradiations with broad-band UVB (Waldmann 85/UV21 lamps) twice a week during 6 weeks. The home UV-device was used each day with the maximal irradiation time of 6 min. The outcome assessment was based on the information obtained from patients' dermatological quality of life (DLQI) questionnaires, the ability of both phototherapies to reduce the provocation reaction and from the patients' evaluation of the long-term benefits of their phototherapies. Sixteen patients completed treatment with SunshowerMedical and thirteen completed treatment in hospital. Both types of phototherapy were effective. There was a highly significant improvement in DLQI with either treatment. In most cases, the hardening reduced or even completely suppressed clinical UV provocation of PLE. The patients using SunshowerMedical at home were, however, much more content with the treatment procedure than the patients visiting the dermatological units. Both treatments were equally effective in the induction of skin tolerance to sunlight in PLE patients. However, the home treatment was much better accepted than the treatment in the hospital. © 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology.

  7. Residual stresses relaxation in surface-hardened half-space under creep conditions

    Directory of Open Access Journals (Sweden)

    Vladimir P. Radchenko

    2015-09-01

    Full Text Available We developed the method for solving the problem of residual stresses relaxation in surface-hardened layer of half-space under creep conditions. At the first stage we made the reconstruction of stress-strain state in half-space after plastic surface hardening procedure based on partial information about distribution for one residual stress tensor component experimentally detected. At the second stage using a numerical method we solve the problem of relaxation of self-balanced residual stresses under creep conditions. To solve this problem we introduce the following Cartesian system: x0y plane is aligned with hardened surface of half-space and 0z axis is directed to the depth of hardened layer. We also introduce the hypotheses of plane sections parallel to x0z and y0z planes. Detailed analysis of the problem has been done. Comparison of the calculated data with the corresponding test data was made for plane specimens (rectangular parallelepipeds made of EP742 alloy during T=650°C after the ultrasonic hardening with four hardening modes. We use half-space to model these specimens because penetration's depth of residual stresses is less than specimen general size in two digit exponent. There is enough correspondence of experimental and calculated data. It is shown that there is a decay (in modulus of pressing residual stresses under creep in 1.4–1.6 times.

  8. Ülemiste City kvartal Tallinnas / Mattias Agabus, Eero Endjärv, Illimar Truverk...[jt.] ; fotod: Kaido Haagen

    Index Scriptorium Estoniae

    2008-01-01

    asendiplaan, 3 korruste plaani, 3 värv. välisvaadet, restorani Mercado sisevaade; projekteerijad: M. Agabus, E. Endjärv, I.Truverk (Agabus, Endjärv & Truverk Arhitektid); hoonete arhitektuurne osa: E. Endjärv; sisearhitektid: K. Lents, H. Kääramees, T. Aunre (restoran Mercado); konstruktorid: Ü. Suvemaa, A. Lehtla, K. Adoberg; maastikuarhitektuur: Ü. Grišakov, M. Agabus, E. Endjärv

  9. Multi-MGy Radiation Hardened Camera for Nuclear Facilities

    International Nuclear Information System (INIS)

    Girard, Sylvain; Boukenter, Aziz; Ouerdane, Youcef; Goiffon, Vincent; Corbiere, Franck; Rolando, Sebastien; Molina, Romain; Estribeau, Magali; Avon, Barbara; Magnan, Pierre; Paillet, Philippe; Duhamel, Olivier; Gaillardin, Marc; Raine, Melanie

    2015-01-01

    There is an increasing interest in developing cameras for surveillance systems to monitor nuclear facilities or nuclear waste storages. Particularly, for today's and the next generation of nuclear facilities increasing safety requirements consecutive to Fukushima Daiichi's disaster have to be considered. For some applications, radiation tolerance needs to overcome doses in the MGy(SiO 2 ) range whereas the most tolerant commercial or prototypes products based on solid state image sensors withstand doses up to few kGy. The objective of this work is to present the radiation hardening strategy developed by our research groups to enhance the tolerance to ionizing radiations of the various subparts of these imaging systems by working simultaneously at the component and system design levels. Developing radiation-hardened camera implies to combine several radiation-hardening strategies. In our case, we decided not to use the simplest one, the shielding approach. This approach is efficient but limits the camera miniaturization and is not compatible with its future integration in remote-handling or robotic systems. Then, the hardening-by-component strategy appears mandatory to avoid the failure of one of the camera subparts at doses lower than the MGy. Concerning the image sensor itself, the used technology is a CMOS Image Sensor (CIS) designed by ISAE team with custom pixel designs used to mitigate the total ionizing dose (TID) effects that occur well below the MGy range in classical image sensors (e.g. Charge Coupled Devices (CCD), Charge Injection Devices (CID) and classical Active Pixel Sensors (APS)), such as the complete loss of functionality, the dark current increase and the gain drop. We'll present at the conference a comparative study between these radiation-hardened pixel radiation responses with respect to conventional ones, demonstrating the efficiency of the choices made. The targeted strategy to develop the complete radiation hard camera

  10. Multi-MGy Radiation Hardened Camera for Nuclear Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Girard, Sylvain; Boukenter, Aziz; Ouerdane, Youcef [Universite de Saint-Etienne, Lab. Hubert Curien, UMR-CNRS 5516, F-42000 Saint-Etienne (France); Goiffon, Vincent; Corbiere, Franck; Rolando, Sebastien; Molina, Romain; Estribeau, Magali; Avon, Barbara; Magnan, Pierre [ISAE, Universite de Toulouse, F-31055 Toulouse (France); Paillet, Philippe; Duhamel, Olivier; Gaillardin, Marc; Raine, Melanie [CEA, DAM, DIF, F-91297 Arpajon (France)

    2015-07-01

    There is an increasing interest in developing cameras for surveillance systems to monitor nuclear facilities or nuclear waste storages. Particularly, for today's and the next generation of nuclear facilities increasing safety requirements consecutive to Fukushima Daiichi's disaster have to be considered. For some applications, radiation tolerance needs to overcome doses in the MGy(SiO{sub 2}) range whereas the most tolerant commercial or prototypes products based on solid state image sensors withstand doses up to few kGy. The objective of this work is to present the radiation hardening strategy developed by our research groups to enhance the tolerance to ionizing radiations of the various subparts of these imaging systems by working simultaneously at the component and system design levels. Developing radiation-hardened camera implies to combine several radiation-hardening strategies. In our case, we decided not to use the simplest one, the shielding approach. This approach is efficient but limits the camera miniaturization and is not compatible with its future integration in remote-handling or robotic systems. Then, the hardening-by-component strategy appears mandatory to avoid the failure of one of the camera subparts at doses lower than the MGy. Concerning the image sensor itself, the used technology is a CMOS Image Sensor (CIS) designed by ISAE team with custom pixel designs used to mitigate the total ionizing dose (TID) effects that occur well below the MGy range in classical image sensors (e.g. Charge Coupled Devices (CCD), Charge Injection Devices (CID) and classical Active Pixel Sensors (APS)), such as the complete loss of functionality, the dark current increase and the gain drop. We'll present at the conference a comparative study between these radiation-hardened pixel radiation responses with respect to conventional ones, demonstrating the efficiency of the choices made. The targeted strategy to develop the complete radiation hard camera

  11. Radiation hardenable coating mixture

    International Nuclear Information System (INIS)

    Howard, D.D.

    1977-01-01

    This invention relates to coatings that harden under radiation and to their compositions. Specifically, this invention concerns unsaturated urethane resins polymerisable by addition and to compositions, hardening under the effect of radiation, containing these resins. These resins feature the presence of at least one unsaturated ethylenic terminal group of structure CH 2 =C and containing the product of the reaction of an organic isocyanate compound with at least two isocyanate groups and one polyester polyol with at least two hydroxyl groups, and one unsaturated monomer compound polymerisable by addition having a single active hydrogen group reacting with the isocyanate [fr

  12. Structure of Rv1848 (UreA), the Mycobacterium tuberculosis urease γ subunit

    International Nuclear Information System (INIS)

    Habel, Jeff E.; Bursey, Evan H.; Rho, Beom-Seop; Kim, Chang-Yub; Segelke, Brent W.; Rupp, Bernhard; Park, Min S.; Terwilliger, Thomas C.; Hung, Li-Wei

    2010-01-01

    Crystal and solution structures of Rv1848 protein and their implications in the biological assembly of Mtb urease is presented. The crystal structure of the urease γ subunit (UreA) from Mycobacterium tuberculosis, Rv1848, has been determined at 1.8 Å resolution. The asymmetric unit contains three copies of Rv1848 arranged into a homotrimer that is similar to the UreA trimer in the structure of urease from Klebsiella aerogenes. Small-angle X-ray scattering experiments indicate that the Rv1848 protein also forms trimers in solution. The observed homotrimer and the organization of urease genes within the M. tuberculosis genome suggest that M. tuberculosis urease has the (αβγ) 3 composition observed for other bacterial ureases. The γ subunit may be of primary importance for the formation of the urease quaternary structure

  13. Work hardening and plastic equation of state of tantalum

    International Nuclear Information System (INIS)

    Gypen, L.A.; Aernoudt, E.; Deruyttere, A.

    1983-01-01

    The influence of cold deformation on the thermal and athermal components of the flow stress of tantalum was investigated. Up to high deformation levels the strain hardening is due only to the development of internal stress fields; the effective stress remains almost constant. The athermal strain hardening of tantalum is parabolic at low deformation levels (epsilon < 0.5) and linear at high deformation levels, as for other bcc metals. Hart's plastic equation of state is shown to be valid for tantalum at room temperature in the whole deformation range investigated (from epsilon = 0.005 to epsilon = 2.8). (author)

  14. A Radiation Hardened Housekeeping Slave Node (RH-HKSN) ASIC

    Data.gov (United States)

    National Aeronautics and Space Administration — This projects seeks to continue the development of the Radiation Hardened Housekeeping Slave Node (RH-HKSN) ASIC. The effort has taken parallel paths by implementing...

  15. 1.55 Å resolution X-ray crystal structure of Rv3902c from Mycobacterium tuberculosis

    Energy Technology Data Exchange (ETDEWEB)

    Reddy, Bharat G.; Moates, Derek B. [University of Alabama at Birmingham, 1025 18th Street South, Birmingham, AL 35233 (United States); Kim, Heung-Bok [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Green, Todd J. [University of Alabama at Birmingham, 1025 18th Street South, Birmingham, AL 35233 (United States); Kim, Chang-Yub; Terwilliger, Thomas C. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); DeLucas, Lawrence J., E-mail: duke2@uab.edu [University of Alabama at Birmingham, 1025 18th Street South, Birmingham, AL 35233 (United States)

    2014-03-25

    The 1.55 Å resolution X-ray crystal structure of Rv3902c from M. tuberculosis reveals a novel fold. The crystallographic structure of the Mycobacterium tuberculosis (TB) protein Rv3902c (176 residues; molecular mass of 19.8 kDa) was determined at 1.55 Å resolution. The function of Rv3902c is unknown, although several TB genes involved in bacterial pathogenesis are expressed from the operon containing the Rv3902c gene. The unique structural fold of Rv3902c contains two domains, each consisting of antiparallel β-sheets and α-helices, creating a hand-like binding motif with a small binding pocket in the palm. Structural homology searches reveal that Rv3902c has an overall structure similar to that of the Salmonella virulence-factor chaperone InvB, with an r.m.s.d. for main-chain atoms of 2.3 Å along an aligned domain.

  16. 1.55 Å resolution X-ray crystal structure of Rv3902c from Mycobacterium tuberculosis

    International Nuclear Information System (INIS)

    Reddy, Bharat G.; Moates, Derek B.; Kim, Heung-Bok; Green, Todd J.; Kim, Chang-Yub; Terwilliger, Thomas C.; DeLucas, Lawrence J.

    2014-01-01

    The 1.55 Å resolution X-ray crystal structure of Rv3902c from M. tuberculosis reveals a novel fold. The crystallographic structure of the Mycobacterium tuberculosis (TB) protein Rv3902c (176 residues; molecular mass of 19.8 kDa) was determined at 1.55 Å resolution. The function of Rv3902c is unknown, although several TB genes involved in bacterial pathogenesis are expressed from the operon containing the Rv3902c gene. The unique structural fold of Rv3902c contains two domains, each consisting of antiparallel β-sheets and α-helices, creating a hand-like binding motif with a small binding pocket in the palm. Structural homology searches reveal that Rv3902c has an overall structure similar to that of the Salmonella virulence-factor chaperone InvB, with an r.m.s.d. for main-chain atoms of 2.3 Å along an aligned domain

  17. Fatigue hardening and softening studies on strain hardened 18-8 austenitic stainless steel

    International Nuclear Information System (INIS)

    Ramakrishna Prasad, C.; Vasudevan, R.

    1976-01-01

    Metals when subjected to fatigue harden or soften depending on their previous mechanical history. Annealed or mildly cold worked metals are known to harden while severely cold worked metals soften when subjected to fatigue loading. In the present work samples of austenitic 18-8 steel cold worked to 11% and 22% reduction in area were mounted in a vertical pulsator and fatigued in axial tension-compression. Clear cut effects were produced and it was noticed that these depended on the extent of cold work, the amplitude as well as the number of cycles of fatigue and mean stress if any. (orig.) [de

  18. Update on radiation-hardened microcomputers for robotics and teleoperated systems

    International Nuclear Information System (INIS)

    Sias, F.R. Jr.; Tulenko, J.S.

    1993-01-01

    Since many programs sponsored by the Department of Defense are being canceled, it is important to select carefully radiation-hardened microprocessors for projects that will mature (or will require continued support) several years in the future. At the present time there are seven candidate 32-bit processors that should be considered for long-range planning for high-performance radiation-hardened computer systems. For Department of Energy applications it is also important to consider efforts at standardization that require the use of the VxWorks operating system and hardware based on the VMEbus. Of the seven processors, one has been delivered and is operating and other systems are scheduled to be delivered late in 1993 or early in 1994. At the present time the Honeywell-developed RH32, the Harris RH-3000 and the Harris RHC-3000 are leading contenders for meeting DOE requirements for a radiation-hardened advanced 32-bit microprocessor. These are all either compatible with or are derivatives of the MIPS R3000 Reduced Instruction Set Computer. It is anticipated that as few as two of the seven radiation-hardened processors will be supported by the space program in the long run

  19. GRAVITY PIPELINE TRANSPORT FOR HARDENING FILLING MIXTURES

    Directory of Open Access Journals (Sweden)

    Leonid KROUPNIK

    2015-12-01

    Full Text Available In underground mining of solid minerals becoming increasingly common development system with stowing hardening mixtures. In this case the natural ore array after it is replaced by an artificial excavation of solidified filling mixture consisting of binder, aggregates and water. Such a mixture is prepared on the surface on special stowing complexes and transported underground at special stowing pipelines. However, it is transported to the horizons of a few kilometers, which requires a sustainable mode of motion of such a mixture in the pipeline. Hardening stowing mixture changes its rheological characteristics over time, which complicates the calculation of the parameters of pipeline transportation. The article suggests a method of determining the initial parameters of such mixtures: the status coefficient, indicator of transportability, coefficient of hydrodynamic resistance to motion of the mixture. These indicators characterize the mixture in terms of the possibility to transport it through pipes. On the basis of these indicators is proposed methodology for calculating the parameters of pipeline transport hardening filling mixtures in drift mode when traffic on the horizontal part of the mixture under pressure column of the mixture in the vertical part of the backfill of the pipeline. This technique allows stable operation is guaranteed to provide pipeline transportation.

  20. Measuring mental health in the clinical setting: what is important to service users? The Mini-Service user Recovery Evaluation scale (Mini-SeRvE).

    Science.gov (United States)

    Barber, Joanna M; Parsons, Helen; Wilson, Carol A; Cook, Christopher C H

    2017-12-01

    Since 2001, a policy of positive mental health recovery has been promoted in the UK, with service user involvement. This has not been easy to implement in the clinical setting. To develop and validate a brief self-report, service user-designed, outcome measure (Mini-SeRvE), for clinical use, including spiritual and religious issues. From the previously developed Service user Recovery Evaluation scale (SeRvE), 15 questions were selected for Mini-SeRvE which was self-completed by 207 people; 100 service users and, for comparison, 107 staff. Results were analysed using SPSS software (SPSS Inc., Chicago, IL). Mini-SeRvE is reliable, Cronbach's alpha 0.852. Correlation with another recovery scale, Mental Health Recovery Measure, was high, r = 0.819. Three reliable subscales emerged; existential well-being (EWB), mental ill-being (MIB) and religious well-being (RWB). Scores of the EWB and MIB subscales were higher for staff, consistent with higher mental well-being. Religious well-being scores were higher in service users, who also rated religion as more important to them. Mini-SeRvE is a valid measure of service user recovery. The importance of religion/spiritual belief for our users is highlighted, this being reflected in the subject matter of Mini-SeRvE. Mini-SeRvE assessments could show individual priorities, evaluate therapy and aid clinical decision-making.

  1. Statistical study of overvoltages by maneuvering in switches in high voltage using EMTP-RV

    International Nuclear Information System (INIS)

    Dominguez Herrera, Diego Armando

    2013-01-01

    The transient overvoltages produced by maneuvering of switches are studied in a statistical way and through a variation the sequential closing times of switches in networks larger than 230 kV. This study is performed according to time delays and typical deviation ranges, using the tool EMTP- RV (ElectroMagnetic Trasient Program Restructured Version). A conceptual framework related with the electromagnetic transients by maneuver is developed in triphasic switches installed in nominal voltages higher than 230 kV. The methodology established for the execution of statistical studies of overvoltages by switch maneuver is reviewed and evaluated by simulating two fictitious cases in EMTP-RV [es

  2. A review of the stages of work hardening

    Energy Technology Data Exchange (ETDEWEB)

    Rollett, A.D.; Kocks, U.F.

    1993-07-01

    Stages of work hardening are reviewed with emphasis on links between each stage. Simple quantitative descriptions are given for each stage. Similarities between stage I, easy glide, and stage IV, large strain hardening, are pointed out both in terms of magnitude of the hardening rate and of the underlying mechanism of dislocation debris accumulation. Stage II is described as an athermal hardening stage that occurs when statistical variations in the dislocation ``forest`` lead to geometrical storage of dislocations. The steadily decreasing hardening rate observed in stage III is characterized by the increasing rate of loss of dislocation density due to dynamic recovery. Stage III appears to have an asymptote to a saturation stress which is determined by the characteristics of the dislocation tangles, or cell walls. The imperfect nature of the dynamic recovery process, however, leads to the accumulation of dislocation debris and this, by analogy with stage 1, causes the apparent saturation stress to rise, thus causing stage IV.

  3. Teadlase eetika / Magnus Ilmjärv

    Index Scriptorium Estoniae

    Ilmjärv, Magnus, 1961-

    2008-01-01

    Vastukaja art.: Valge, Jaak. Pätsi riigipööret ei inspireeritud väljastpoolt // Postimees (2008) 26. apr., lk. 13. President Konstantin Pätsi kohta leitud uutest arhiivimaterjalidest. Raamatu "Hääletu alistumine" autor, ajaloolane Magnus Ilmjärv peab Jaak Valge kriitikat tema suhtes põhjendamatult suureks

  4. Effects of kinematic hardening rules on thermal ratchetting analysis of cylinders subjected to cyclically moving temperature distribution

    International Nuclear Information System (INIS)

    Ohno, N.; Kobayashi, M.

    1995-01-01

    In the present work, thermal ratchetting in a cylinder subjected to a cyclically moving temperature front (i.e. liquid surface induced thermal ratchetting) was analyzed by implementing in a finite element method the four kinds of plasticity models with different kinematic hardening rules. The following findings were thus obtained concerning effects of the kinematic hardening rules on the analysis. (1) If transition nonlinear hardening after yielding is disregarded, the thermal ratchetting becomes significant, as seen in the results of the PP and LKH models. Especially the PP model, which does not express any strain hardening, predicts steady development of the thermal ratchetting. (2) If significant mechanical ratchetting is allowed in the modeling of kinematic hardening, the thermal ratchetting becomes marked, as seen in the results of the AF model. (3) Model dependence of the thermal ratchetting is more noticeable when the difference of temperature at the temperature front, ΔT, is smaller. (4) The OW model makes the thermal ratchetting stop at a smaller number of cycles when ΔT is smaller. On the other hand, the LKH and AF models allow that the thermal ratchetting to develop more constantly when ΔT is smaller. As seen from the above findings, the analysis of liquid surface induced thermal ratchetting has great dependence on the kinematic hardening rules employed. Especially the PP model, which has been used often to analyze the thermal ratchetting so far, gives too large development of the thermal ratchetting. Thus we may say that in order to improve the analysis it is necessary to use an appropriate kinematic hardening model which is capable of expressing appropriately both mechanical ratchetting and transient nonlinear hardening after yielding. (author)

  5. Radiation Hardened Ethernet PHY and Switch Fabric, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Innoflight will develop a new family of radiation hardened (up to 3 Mrad(Si)), fault-tolerant, high data-rate (up to 8 Gbps), low power Gigabit Ethernet PHY and...

  6. Two Back Stress Hardening Models in Rate Independent Rigid Plastic Deformation

    Science.gov (United States)

    Yun, Su-Jin

    In the present work, the constitutive relations based on the combination of two back stresses are developed using the Armstrong-Frederick, Phillips and Ziegler’s type hardening rules. Various evolutions of the kinematic hardening parameter can be obtained by means of a simple combination of back stress rate using the rule of mixtures. Thus, a wide range of plastic deformation behavior can be depicted depending on the dominant back stress evolution. The ultimate back stress is also determined for the present combined kinematic hardening models. Since a kinematic hardening rule is assumed in the finite deformation regime, the stress rate is co-rotated with respect to the spin of substructure obtained by incorporating the plastic spin concept. A comparison of the various co-rotational rates is also included. Assuming rigid plasticity, the continuum body consists of the elastic deformation zone and the plastic deformation zone to form a hybrid finite element formulation. Then, the plastic deformation behavior is investigated under various loading conditions with an assumption of the J2 deformation theory. The plastic deformation localization turns out to be strongly dependent on the description of back stress evolution and its associated hardening parameters. The analysis for the shear deformation with fixed boundaries is carried out to examine the deformation localization behavior and the evolution of state variables.

  7. Infection with koala retrovirus subgroup B (KoRV-B), but not KoRV-A, is associated with chlamydial disease in free-ranging koalas (Phascolarctos cinereus)

    OpenAIRE

    Waugh, Courtney A.; Hanger, Jonathan; Loader, Joanne; King, Andrew; Hobbs, Matthew; Johnson, Rebecca; Timms, Peter

    2017-01-01

    The virulence of chlamydial infection in wild koalas is highly variable between individuals. Some koalas can be infected (PCR positive) with Chlamydia for long periods but remain asymptomatic, whereas others develop clinical disease. Chlamydia in the koala has traditionally been studied without regard to coinfection with other pathogens, although koalas are usually subject to infection with koala retrovirus (KoRV). Retroviruses can be immunosuppressive, and there is evidence of an immunosuppr...

  8. Investigation of a Hardened Cement Paste Grout

    DEFF Research Database (Denmark)

    Esteves, Luis Pedro; Sørensen, Eigil Verner

    This report documents a series of tests performed on a hardened cement paste grout delivered by the client, Det Norske Veritas A/S.......This report documents a series of tests performed on a hardened cement paste grout delivered by the client, Det Norske Veritas A/S....

  9. Stringent DDI-based prediction of H. sapiens-M. tuberculosis H37Rv protein-protein interactions.

    Science.gov (United States)

    Zhou, Hufeng; Rezaei, Javad; Hugo, Willy; Gao, Shangzhi; Jin, Jingjing; Fan, Mengyuan; Yong, Chern-Han; Wozniak, Michal; Wong, Limsoon

    2013-01-01

    H. sapiens-M. tuberculosis H37Rv protein-protein interaction (PPI) data are very important information to illuminate the infection mechanism of M. tuberculosis H37Rv. But current H. sapiens-M. tuberculosis H37Rv PPI data are very scarce. This seriously limits the study of the interaction between this important pathogen and its host H. sapiens. Computational prediction of H. sapiens-M. tuberculosis H37Rv PPIs is an important strategy to fill in the gap. Domain-domain interaction (DDI) based prediction is one of the frequently used computational approaches in predicting both intra-species and inter-species PPIs. However, the performance of DDI-based host-pathogen PPI prediction has been rather limited. We develop a stringent DDI-based prediction approach with emphasis on (i) differences between the specific domain sequences on annotated regions of proteins under the same domain ID and (ii) calculation of the interaction strength of predicted PPIs based on the interacting residues in their interaction interfaces. We compare our stringent DDI-based approach to a conventional DDI-based approach for predicting PPIs based on gold standard intra-species PPIs and coherent informative Gene Ontology terms assessment. The assessment results show that our stringent DDI-based approach achieves much better performance in predicting PPIs than the conventional approach. Using our stringent DDI-based approach, we have predicted a small set of reliable H. sapiens-M. tuberculosis H37Rv PPIs which could be very useful for a variety of related studies. We also analyze the H. sapiens-M. tuberculosis H37Rv PPIs predicted by our stringent DDI-based approach using cellular compartment distribution analysis, functional category enrichment analysis and pathway enrichment analysis. The analyses support the validity of our prediction result. Also, based on an analysis of the H. sapiens-M. tuberculosis H37Rv PPI network predicted by our stringent DDI-based approach, we have discovered some

  10. Deflection hardening behaviour of short fibre reinforced fly ash based geopolymer composites

    International Nuclear Information System (INIS)

    Shaikh, F.U.A.

    2013-01-01

    Highlights: • Deflection hardening behaviour is achieved in the DFRGC similar to that observed in DFRCC. • The first crack load or in other word the limit of proportionality (LOP) of DFRGC is similar to that of DFRCC. • The DFRGC also exhibited higher deflection at peak load than DFRCC. • The toughness at peak load of DFRGC is also high than that of DFRCC. • The ductility of DFRGC is also higher than that of DFRCC. - Abstract: This paper reports the newly developed ductile fibre reinforced geopolymer composite (DFRGC) exhibiting deflection hardening and multiple cracking behaviour. The binder of the above composite is different from that used in conventional cement based system. The class F fly ash is used instead of Portland cement in DFRGC and is activated by alkaline liquids (sodium hydroxide and sodium silicate). In this study, two types of fibres namely steel (ST) and polyvinyl alcohol (PVA) fibres are used in mono as well as in ST–PVA hybrid form, with a total volume fraction of 2%. The deflection hardening behaviour of newly developed DFRGC is also compared with that of conventional ductile fibre reinforced cementitious composites (DFRCC). The effects of two different sizes of sand (1.18 mm, and 0.6 mm) and sand/binder ratios of 0.5 and 0.75 on the deflection hardening and multiple cracking behaviour of both DFRGC and DFRCC are also evaluated. Results revel that the deflection hardening and multiple cracking behaviour is achieved in geopolymer based DFRGC similar to that of cement based system. For a given sand size and sand content, comparable deflection hardening behaviour, ultimate flexural strength and the deflection at peak load are observed in both cement and geopolymer based composites irrespective of fibre types and combination. The deflection hardening behaviour of DFRGC is also confirmed by the calculated toughness index values of I 20 > 20. The scanning electron microscope (SEM) study shows no degradation of PVA and steel fibres in the

  11. Mycobacterium tuberculosis Latent Antigen Rv2029c from the Multistage DNA Vaccine A39 Drives TH1 Responses via TLR-mediated Macrophage Activation

    Directory of Open Access Journals (Sweden)

    Haibo Su

    2017-11-01

    Full Text Available Targeting of Mycobacterium tuberculosis (MTB latent antigens comprises a crucial strategy for the development of alternative tuberculosis (TB vaccine(s that protects against TB reactivation. Here, we generated a multistage DNA vaccine, A39, containing the early antigens Ag85A and Rv3425 as well as the latency-associated protein Rv2029c, which conferred protective immunity in a pre-exposure mouse model. Moreover, administration of the A39 vaccination after MTB exposure inhibited reactivation and resulted in significantly lower bacterial loads in the lungs and spleen of mice, compared to those in the control population. Subsequently, we investigated the effect of Rv2029c on innate immunity and characterized the molecular details of the interaction of this protein with the host via iTRAQ proteomic and biochemical assay analyses. Rv2029c activated macrophages, triggered the production of pro-inflammatory cytokines, and promoted toll-like receptor/mitogen-activated protein kinase (TLR/MAPK-dependent macrophage apoptosis. Furthermore, Rv2029c treatment enhanced the ability of Mycobacterium bovis Bacillus Calmette-Guérin (BCG-infected macrophages to present antigens to CD4+ T cells in vitro, which correlated with an increase in MHC-II expression. Lastly, Rv2029c-treated macrophages activated T cells, effectively polarized CD4+ and CD8+ T cells to secrete IFN-γ and IL-2, and specifically expanded a population of CD44highCD62LlowCD4+/CD8+ effector/memory cells, indicating that Rv2029c, as a specific recall antigen, contributes to Th1 polarization in T cell immunity. These results suggest that Rv2029c and A39 comprise promising targets for the development of next-generation clinical TB therapeutic vaccines.

  12. Temperature dependence of work hardening in sparsely twinning zirconium

    International Nuclear Information System (INIS)

    Singh, Jaiveer; Mahesh, S.; Roy, Shomic; Kumar, Gulshan; Srivastava, D.; Dey, G.K.; Saibaba, N.; Samajdar, I.

    2017-01-01

    Fully recrystallized commercial Zirconium plates were subjected to uniaxial tension. Tests were conducted at different temperatures (123 K - 623 K) and along two plate directions. Both directions were nominally unfavorable for deformation twinning. The effect of the working temperature on crystallographic texture and in-grain misorientation development was insignificant. However, systematic variation in work hardening and in the area fraction and morphology of deformation twins was observed with temperature. At all temperatures, twinning was associated with significant near boundary mesoscopic shear, suggesting a possible linkage with twin nucleation. A binary tree based model of the polycrystal, which explicitly accounts for grain boundary accommodation and implements the phenomenological extended Voce hardening law, was implemented. This model could capture the measured stress-strain response and twin volume fractions accurately. Interestingly, slip and twin system hardness evolution permitted multiplicative decomposition into temperature-dependent, and accumulated strain-dependent parts. Furthermore, under conditions of relatively limited deformation twinning, the work hardening of the slip and twin systems followed two phenomenological laws proposed in the literature for non-twinning single-phase face centered cubic materials.

  13. Rationale and design of the ranolazine PH-RV study: a multicentred randomised and placebo-controlled study of ranolazine to improve RV function in patients with non-group 2 pulmonary hypertension.

    Science.gov (United States)

    Han, Yuchi; Forfia, Paul R; Vaidya, Anjali; Mazurek, Jeremy A; Park, Myung H; Ramani, Gautam; Chan, Stephen Y; Waxman, Aaron B

    2018-01-01

    A major determining factor on outcomes in patients with pulmonary arterial hypertension (PAH) is right ventricular (RV) function. Ranolazine, which is currently approved for chronic stable angina, has been shown to improve RV function in an animal model and has been shown to be safe in small human studies with PAH. We aim to study the effect of ranolazine on RV function using cardiovascular magnetic resonance (CMR) in patients with pulmonary hypertension (non-group 2 patients) and monitor the effect of ranolazine on metabolism using metabolic profiling and changes of microRNA. This study is a longitudinal, randomised, double-blind, placebo-controlled, multicentre proof-of-concept study in 24 subjects with pulmonary hypertension and RV dysfunction treated with ranolazine over 6 months. Subjects who meet the protocol definition of RV dysfunction (CMR RV ejection fraction (EF) <45%) will be randomised to ranolazine or placebo with a ratio of 2:1. Enrolled subjects will be assessed for functional class, 6 min walk test and health outcome based on SF-36 tool. Peripheral blood will be obtained for N-terminal-pro brain natriuretic peptide, metabolic profiling, and microRNA at baseline and the conclusion of the treatment period. CMR will be performed at baseline and the conclusion of the treatment period. The primary outcome is change in RVEF. The exploratory outcomes include clinical, other CMR parameters, metabolic and microRNA changes. The trial protocol was approved by Institutional Review Boards. The trial findings will be disseminated in scientific journals and meetings. NCT01839110 and NCT02829034; Pre-results.

  14. Significance of rate of work hardening in tempered martensite embrittlement

    International Nuclear Information System (INIS)

    Pietikainen, J.

    1995-01-01

    The main explanations for tempered martensite embrittlement are based on the effects of impurities and cementite precipitation on the prior austenite grain boundaries. There are some studies where the rate of work hardening is proposed as a potential reason for the brittleness. One steel was studied by means of a specially developed precision torsional testing device. The test steel had a high Si and Ni content so ε carbide and Fe 3 C appear in quite different tempering temperature ranges. The M S temperature is low enough so that self tempering does not occur. With the testing device it was possible to obtain the true stress - true strain curves to very high deformations. The minimum toughness was always associated with the minimum of rate of work hardening. The change of deformed steel volume before the loss of mechanical stability is proposed as at least one reason for tempered martensite embrittlement. The reasons for the minimum of the rate of work hardening are considered. (orig.)

  15. Disorientations and their role on the work-hardening in stage IV

    DEFF Research Database (Denmark)

    Pantleon, W.

    2005-01-01

    statistical reasons still lead to stage III behavior and a saturation of the ow stress, but deterministic contributions to the development of disorienta- tions, as dierences in activated slip systems across boundaries, cause a linear increase of the flow stress at large strains. Such a constant work......The eect of deformation-induced disorientations on work-hardening of metals is modelled by dislocation dynamics. By incorporating excess dislocations related to disori- entations, Kocks' dislocation model describing stage III hardening is extended to stage IV. Disorientations evolving from purely...

  16. Stringent homology-based prediction of H. sapiens-M. tuberculosis H37Rv protein-protein interactions.

    Science.gov (United States)

    Zhou, Hufeng; Gao, Shangzhi; Nguyen, Nam Ninh; Fan, Mengyuan; Jin, Jingjing; Liu, Bing; Zhao, Liang; Xiong, Geng; Tan, Min; Li, Shijun; Wong, Limsoon

    2014-04-08

    H. sapiens-M. tuberculosis H37Rv protein-protein interaction (PPI) data are essential for understanding the infection mechanism of the formidable pathogen M. tuberculosis H37Rv. Computational prediction is an important strategy to fill the gap in experimental H. sapiens-M. tuberculosis H37Rv PPI data. Homology-based prediction is frequently used in predicting both intra-species and inter-species PPIs. However, some limitations are not properly resolved in several published works that predict eukaryote-prokaryote inter-species PPIs using intra-species template PPIs. We develop a stringent homology-based prediction approach by taking into account (i) differences between eukaryotic and prokaryotic proteins and (ii) differences between inter-species and intra-species PPI interfaces. We compare our stringent homology-based approach to a conventional homology-based approach for predicting host-pathogen PPIs, based on cellular compartment distribution analysis, disease gene list enrichment analysis, pathway enrichment analysis and functional category enrichment analysis. These analyses support the validity of our prediction result, and clearly show that our approach has better performance in predicting H. sapiens-M. tuberculosis H37Rv PPIs. Using our stringent homology-based approach, we have predicted a set of highly plausible H. sapiens-M. tuberculosis H37Rv PPIs which might be useful for many of related studies. Based on our analysis of the H. sapiens-M. tuberculosis H37Rv PPI network predicted by our stringent homology-based approach, we have discovered several interesting properties which are reported here for the first time. We find that both host proteins and pathogen proteins involved in the host-pathogen PPIs tend to be hubs in their own intra-species PPI network. Also, both host and pathogen proteins involved in host-pathogen PPIs tend to have longer primary sequence, tend to have more domains, tend to be more hydrophilic, etc. And the protein domains from both

  17. Simulation of irradiation hardening of Zircaloy within plate-type dispersion nuclear fuel elements

    Science.gov (United States)

    Jiang, Yijie; Wang, Qiming; Cui, Yi; Huo, Yongzhong; Ding, Shurong

    2011-06-01

    Within plate-type dispersion nuclear fuel elements, the metal matrix and cladding attacked continuously by fast neutrons undergo irradiation hardening, which might have remarkable effects upon the mechanical behaviors within fuel elements. In this paper, with the irradiation hardening effect of metal materials mainly considered together with irradiation growth effect of the cladding, the three-dimensional large-deformation constitutive relations for the metal matrix and cladding are developed. The method of virtual temperature increase in the previous studies is further developed to model the irradiation swelling of fuel particles; the method of anisotropic thermal expansion is introduced to model irradiation growth of the cladding; and a method of multi-step-temperature loading is proposed to simulate the coupling features of irradiation-induced swelling of the fuel particles together with irradiation growth of the cladding. Above all, based on the developed relationship between irradiation growth at certain burnup and the loaded virtual temperatures, with considering that certain burnup corresponds to certain fast neutron fluence, the time-dependent constitutive relation due to irradiation hardening effect is replaced by the virtual-temperature-dependent one which is introduced into the commercial software to simulate the irradiation hardening effects of the matrix and cladding. Numerical simulations of the irradiation-induced mechanical behaviors are implemented with the finite element method in consideration of the micro-structure of the fuel meat. The obtained results indicate that when the irradiation hardening effects are introduced into the constitutive relations of the metal matrix and cladding: (1) higher maximum Mises stresses for certain burnup at the matrix exist with the equivalent plastic strains remaining almost the same at lower burnups; (2) the maximum Mises stresses for certain burnup at the cladding are enhanced while the maximum equivalent

  18. Simulation of irradiation hardening of Zircaloy within plate-type dispersion nuclear fuel elements

    Energy Technology Data Exchange (ETDEWEB)

    Jiang Yijie; Wang Qiming; Cui Yi; Huo Yongzhong [Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433 (China); Ding Shurong, E-mail: dsr1971@163.com [Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433 (China)

    2011-06-15

    Within plate-type dispersion nuclear fuel elements, the metal matrix and cladding attacked continuously by fast neutrons undergo irradiation hardening, which might have remarkable effects upon the mechanical behaviors within fuel elements. In this paper, with the irradiation hardening effect of metal materials mainly considered together with irradiation growth effect of the cladding, the three-dimensional large-deformation constitutive relations for the metal matrix and cladding are developed. The method of virtual temperature increase in the previous studies is further developed to model the irradiation swelling of fuel particles; the method of anisotropic thermal expansion is introduced to model irradiation growth of the cladding; and a method of multi-step-temperature loading is proposed to simulate the coupling features of irradiation-induced swelling of the fuel particles together with irradiation growth of the cladding. Above all, based on the developed relationship between irradiation growth at certain burnup and the loaded virtual temperatures, with considering that certain burnup corresponds to certain fast neutron fluence, the time-dependent constitutive relation due to irradiation hardening effect is replaced by the virtual-temperature-dependent one which is introduced into the commercial software to simulate the irradiation hardening effects of the matrix and cladding. Numerical simulations of the irradiation-induced mechanical behaviors are implemented with the finite element method in consideration of the micro-structure of the fuel meat. The obtained results indicate that when the irradiation hardening effects are introduced into the constitutive relations of the metal matrix and cladding: (1) higher maximum Mises stresses for certain burnup at the matrix exist with the equivalent plastic strains remaining almost the same at lower burnups; (2) the maximum Mises stresses for certain burnup at the cladding are enhanced while the maximum equivalent

  19. Linear Friction Welding Process Model for Carpenter Custom 465 Precipitation-Hardened Martensitic Stainless Steel

    Science.gov (United States)

    2014-04-11

    Carpenter Custom 465 precipitation-hardened martensitic stainless steel to develop a linear friction welding (LFW) process model for this material...Model for Carpenter Custom 465 Precipitation-Hardened Martensitic Stainless Steel The views, opinions and/or findings contained in this report are... Martensitic Stainless Steel Report Title An Arbitrary Lagrangian-Eulerian finite-element analysis is combined with thermo-mechanical material

  20. New Stainless Steel Alloys for Low Temperature Surface Hardening?

    DEFF Research Database (Denmark)

    Christiansen, Thomas Lundin; Dahl, Kristian Vinter; Somers, Marcel A. J.

    2015-01-01

    The present contribution showcases the possibility for developing new surface hardenable stainless steels containing strong nitride/carbide forming elements (SNCFE). Nitriding of the commercial alloys, austenitic A286, and ferritic AISI 409 illustrates the beneficial effect of having SNCFE presen...

  1. COMPLEX SURFACE HARDENING OF STEEL ARTICLES

    Directory of Open Access Journals (Sweden)

    A. V. Kovalchuk

    2014-01-01

    Full Text Available The method of complex surface hardening of steel detailswas designed. The method is a compound of two processes of hardening: chemical heat treatment and physical vapor deposition (PVD of the coating. The result, achieved in this study is much higher, than in other work on this topic and is cumulative. The method designed can be used in mechanical engineering, medicine, energetics and is perspective for military and space technologies.

  2. Effect of solute elements on hardening of thermally-aged RPV model alloys

    International Nuclear Information System (INIS)

    Nomoto, A.; Nishida, K.; Dohi, K.; Soneda, N.; Liu, L.; Sekimura, N.; Li, Z.

    2015-01-01

    Embrittlement correlation methods for irradiated reactor pressure vessel (RPV) steels have been developed worldwide to predict the amount of embrittlement during plant operation. The effect of chemical composition on embrittlement is not fully understood, particularly the process of solute atom behavior during solute atom formation. In this series of slides we report the results of thermal ageing experiments of RPV model alloys in order to obtain information on the effect of chemical composition on the hardening process. We can draw the following conclusions. First, the addition of Ni or Si alone to Fe-Cu model alloys does not have clear effect but the addition of Mn to Fe-Cu-Ni alloy accelerates the cluster formation and hardening drastically, the effect of composition on the cluster strength is not clear. Secondly, the hardening process before the hardening peak has linear correlation with APT (Atom Probe Tomography) results and the RSS (Root-Sum-Square)sum model seems to explain the relationship between increase in hardness and APT data in a more consistent manner

  3. Potential Mechanism of Action of meso-Dihydroguaiaretic Acid on Mycobacterium tuberculosis H37Rv

    Directory of Open Access Journals (Sweden)

    Aldo F. Clemente-Soto

    2014-12-01

    Full Text Available The isolation and characterization of the lignan meso-dihydroguaiaretic acid (MDGA from Larrea tridentata and its activity against Mycobacterial tuberculosis has been demonstrated, but no information regarding its mechanism of action has been documented. Therefore, in this study we carry out the gene expression from total RNA obtained from M. tuberculosis H37Rv treated with MDGA using microarray technology, which was validated by quantitative real time polymerase chain reaction. Results showed that the alpha subunit of coenzyme A transferase of M. tuberculosis H37Rv is present in both geraniol and 1-and 2-methylnaphthalene degradation pathways, which are targeted by MDGA. This assumption was supported by molecular docking which showed stable interaction between MDGA with the active site of the enzyme. We propose that inhibition of coenzyme A transferase of M. tuberculosis H37Rv results in the accumulation of geraniol and 1-and 2-methylnaphtalene inside bacteria, causing membrane destabilization and death of the pathogen. The natural product MDGA is thus an attractive template to develop new anti-tuberculosis drugs, because its target is different from those of known anti-tubercular agents.

  4. Rv2477c is an antibiotic-sensitive manganese-dependent ABC-F ATPase in Mycobacterium tuberculosis.

    Science.gov (United States)

    Daniel, Jaiyanth; Abraham, Liz; Martin, Amanda; Pablo, Xyryl; Reyes, Shelby

    2018-01-01

    The Rv2477c protein of Mycobacterium tuberculosis (Mtb) belongs to the ATP-binding cassette (ABC) subfamily F that contains proteins with tandem nucleotide-binding domains but lacking transmembrane domains. ABC-F subfamily proteins have been implicated in diverse cellular processes such as translation, antibiotic resistance, cell growth and nutrient sensing. In order to investigate the biochemical characteristics of Rv2477c, we expressed it in Escherichia coli, purified it and characterized its enzymatic functions. We show that Rv2477c displays strong ATPase activity (V max  = 45.5 nmol/mg/min; K m  = 90.5 μM) that is sensitive to orthovanadate. The ATPase activity was maximal in the presence of Mn 2+ at pH 5.2. The Rv2477c protein was also able to hydrolyze GTP, TTP and CTP but at lower rates. Glutamate to glutamine substitutions at amino acid residues 185 and 468 in the two Walker B motifs of Rv2477c severely inhibited its ATPase activity. The antibiotics tetracycline and erythromycin, which target protein translation, were able to inhibit the ATPase activity of Rv2477c. We postulate that Rv2477c could be involved in mycobacterial protein translation and in resistance to tetracyclines and macrolides. This is the first report of the biochemical characterization of an ABC-F subfamily protein in Mtb. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Hardening of niobium alloys at precrystallization annealing

    International Nuclear Information System (INIS)

    Vasil'eva, E.V.; Pustovalov, V.A.

    1989-01-01

    Niobium base alloys were investigated. It is shown that precrystallization annealing of niobium-molybdenum, niobium-vanadium and niobium-zirconium alloys elevates much more sufficiently their resistance to microplastic strains, than to macroplastic strains. Hardening effect differs sufficiently for different alloys. The maximal hardening is observed for niobium-vanadium alloys, the minimal one - for niobium-zirconium alloys

  6. Mycobacterium tuberculosis Universal Stress Protein Rv2623 Regulates Bacillary Growth by ATP Binding: Requirement for Establishing Chronic Persistent Infection

    Energy Technology Data Exchange (ETDEWEB)

    Drumm, J.; Mi, K; Bilder, P; Sun, M; Lim, J; Bielefeldt-Ohmann, H; Basaraba, R; So, M; Zhu, G; et. al.

    2009-01-01

    Tuberculous latency and reactivation play a significant role in the pathogenesis of tuberculosis, yet the mechanisms that regulate these processes remain unclear. The Mycobacterium tuberculosisuniversal stress protein (USP) homolog, rv2623, is among the most highly induced genes when the tubercle bacillus is subjected to hypoxia and nitrosative stress, conditions thought to promote latency. Induction of rv2623 also occurs when M. tuberculosis encounters conditions associated with growth arrest, such as the intracellular milieu of macrophages and in the lungs of mice with chronic tuberculosis. Therefore, we tested the hypothesis that Rv2623 regulates tuberculosis latency. We observed that an Rv2623-deficient mutant fails to establish chronic tuberculous infection in guinea pigs and mice, exhibiting a hypervirulence phenotype associated with increased bacterial burden and mortality. Consistent with this in vivo growth-regulatory role, constitutive overexpression of rv2623 attenuates mycobacterial growth in vitro. Biochemical analysis of purified Rv2623 suggested that this mycobacterial USP binds ATP, and the 2.9-A-resolution crystal structure revealed that Rv2623 engages ATP in a novel nucleotide-binding pocket. Structure-guided mutagenesis yielded Rv2623 mutants with reduced ATP-binding capacity. Analysis of mycobacteria overexpressing these mutants revealed that the in vitro growth-inhibitory property of Rv2623 correlates with its ability to bind ATP. Together, the results indicate that i M. tuberculosis Rv2623 regulates mycobacterial growth in vitro and in vivo, and ii Rv2623 is required for the entry of the tubercle bacillus into the chronic phase of infection in the host; in addition, iii Rv2623 binds ATP; and iv the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. We propose that Rv2623 may function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection.

  7. Model Identification and FE Simulations: Effect of Different Yield Loci and Hardening Laws in Sheet Forming

    International Nuclear Information System (INIS)

    Flores, P.; Lelotte, T.; Bouffioux, C.; El Houdaigui, F.; Habraken, A.M.; Duchene, L.; Bael, A. van; He, S.; Duflou, J.

    2005-01-01

    The bi-axial experimental equipment developed by Flores enables to perform Baushinger shear tests and successive or simultaneous simple shear tests and plane-strain tests. Such experiments and classical tensile tests investigate the material behavior in order to identify the yield locus and the hardening models. With tests performed on two steel grades, the methods applied to identify classical yield surfaces such as Hill or Hosford ones as well as isotropic Swift type hardening or kinematic Armstrong-Frederick hardening models are explained. Comparison with the Taylor-Bishop-Hill yield locus is also provided. The effect of both yield locus and hardening model choice will be presented for two applications: Single Point Incremental Forming (SPIF) and a cup deep drawing

  8. Model Identification and FE Simulations: Effect of Different Yield Loci and Hardening Laws in Sheet Forming

    Science.gov (United States)

    Flores, P.; Duchêne, L.; Lelotte, T.; Bouffioux, C.; El Houdaigui, F.; Van Bael, A.; He, S.; Duflou, J.; Habraken, A. M.

    2005-08-01

    The bi-axial experimental equipment developed by Flores enables to perform Baushinger shear tests and successive or simultaneous simple shear tests and plane-strain tests. Such experiments and classical tensile tests investigate the material behavior in order to identify the yield locus and the hardening models. With tests performed on two steel grades, the methods applied to identify classical yield surfaces such as Hill or Hosford ones as well as isotropic Swift type hardening or kinematic Armstrong-Frederick hardening models are explained. Comparison with the Taylor-Bishop-Hill yield locus is also provided. The effect of both yield locus and hardening model choice will be presented for two applications: Single Point Incremental Forming (SPIF) and a cup deep drawing.

  9. Three-dimensional models of Mycobacterium tuberculosis proteins Rv1555, Rv1554 and their docking analyses with sildenafil, tadalafil, vardenafil drugs, suggest interference with quinol binding likely to affect protein's function.

    Science.gov (United States)

    Dash, Pallabini; Bala Divya, M; Guruprasad, Lalitha; Guruprasad, Kunchur

    2018-04-18

    Earlier based on bioinformatics analyses, we had predicted the Mycobacterium tuberculosis (M.tb) proteins; Rv1555 and Rv1554, among the potential new tuberculosis drug targets. According to the 'TB-drugome' the Rv1555 protein is 'druggable' with sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra) drugs. In the present work, we intended to understand via computer modeling studies, how the above drugs are likely to inhibit the M.tb protein's function. The three-dimensional computer models for M.tb proteins; Rv1555 and Rv1554 constructed on the template of equivalent membrane anchor subunits of the homologous E.coli quinol fumarate reductase respiratory protein complex, followed by drug docking analyses, suggested that the binding of above drugs interferes with quinol binding sites. Also, we experimentally observed the in-vitro growth inhibition of E.coli bacteria containing the homologous M.tb protein sequences with sildenafil and tadalafil drugs. The predicted binding sites of the drugs is likely to affect the above M.tb proteins function as quinol binding is known to be essential for electron transfer function during anaerobic respiration in the homologous E.coli protein complex. Therefore, sildenafil and related drugs currently used in the treatment of male erectile dysfunction targeting the human phosphodiesterase 5 enzyme may be evaluated for their plausible role as repurposed drugs to treat human tuberculosis.

  10. Radiation-hardened nonvolatile MNOS RAM

    International Nuclear Information System (INIS)

    Wrobel, T.F.; Dodson, W.H.; Hash, G.L.; Jones, R.V.; Nasby, R.D.; Olson, R.J.

    1983-01-01

    A radiation hardened nonvolatile MNOS RAM is being developed at Sandia National Laboratories. The memory organization is 128 x 8 bits and utilizes two p-channel MNOS transistors per memory cell. The peripheral circuitry is constructed with CMOS metal gate and is processed with standard Sandia rad-hard processing techniques. The devices have memory retention after a dose-rate exposure of 1E12 rad(Si)/s, are functional after total dose exposure of 1E6 rad(Si), and are dose-rate upset resistant to levels of 7E8 rad(Si)/s

  11. Hardening device, by inserts, of electronic component against radiation

    International Nuclear Information System (INIS)

    Val, C.

    1987-01-01

    The hardening device includes at least two materials, one with high atomic number with respect to the other. One of these materials is set as inserts in a layer of the other material. The hardening device is then made by stacking of such layers, the insert density varying from one layer to the other, making thus vary the atomic number resulting from the hardening device along its thickness, following a predefined law [fr

  12. Investigation of srawberry hardening in low temperatures in vitro

    OpenAIRE

    Lukoševičiūtė, Vanda; Rugienius, Rytis; Kavaliauskaitė, Danguolė

    2007-01-01

    Cold resistance of different strawberry varieties in vitro and ability to retain hardening after defrosting and repeated hardening. Phytohormons – gibberellin and abscisic acid added in the growing medium were investigated in Horticulture plant genetic and biotechnology department of LIH. We tried to model common conditions in temperate zone when freeze-thaw cycles often occur during wintertime. For investigation in vitro strawberries for the first time hardened in light at the temperature of...

  13. Work Hardening Behavior of 1020 Steel During Cold-Beating Simulation

    Science.gov (United States)

    CUI, Fengkui; LING, Yuanfei; XUE, Jinxue; LIU, Jia; LIU, Yuhui; LI, Yan

    2017-03-01

    The present research of cold-beating formation mainly focused on roller design and manufacture, kinematics, constitutive relation, metal flow law, thermo-mechanical coupling, surface micro-topography and microstructure evolution. However, the research on surface quality and performance of workpieces in the process of cold-beating is rare. Cold-beating simulation experiment of 1020 steel is conducted at room temperature and strain rates ranging from 2000 to 4000 s-1 base on the law of plastic forming. According to the experimental data, the model of strain hardening of 1020 steel is established, Scanning Electron Microscopy(SEM) is conducted, the mechanism of the work hardening of 1020 steel is clarified by analyzing microstructure variation of 1020 steel. It is found that the strain rate hardening effect of 1020 steel is stronger than the softening effect induced by increasing temperatures, the process of simulation cold-beating cause the grain shape of 1020 steel significant change and microstructure elongate significantly to form a fibrous tissue parallel to the direction of deformation, the higher strain rate, the more obvious grain refinement and the more hardening effect. Additionally, the change law of the work hardening rate is investigated, the relationship between dislocation density and strain, the relationship between work hardening rate and dislocation density is obtained. Results show that the change trend of the work hardening rate of 1020 steel is divided into two stages, the work hardening rate decreases dramatically in the first stage and slowly decreases in the second stage, finally tending toward zero. Dislocation density increases with increasing strain and strain rate, work hardening rate decreases with increasing dislocation density. The research results provide the basis for solving the problem of improving the surface quality and performance of workpieces under cold-beating formation of 1020 steel.

  14. HARDENING OF CRANE RAILS BY PLASMA DISCRETE-TIME SURFACE TREATMENT

    Directory of Open Access Journals (Sweden)

    S. S. Samotugin

    2017-01-01

    Full Text Available Crane wheels and rails are subjected to intensive wear in the process of operation. Therefore, improvement of these components’ performance can be considered a task of high importance. A promising direction in this regard is surface treatment by highly concentrated energy flows such as laser beams or plasma jets. This thesis suggests that the use of gradient plasma surface treatment can improve the performance of crane rails. A research was conducted, according to which hardened zones were deposited on crane rails under different treatment modes. Microhardness was measured both at the surface and in depth using custom-made microsections. The article includes the results of study of plasma surface hardening effects on wear resistance of crane rails. Change of plasma surface treatment parameters (current, plasma torch movement speed, argon gas flow rate allows for desired steel hardness and structure, while the choice of optimal location for hardened zones makes it possible to significantly improve wear resistance and crack resistance. As a result of plasma surface hardening, the fine-grained martensite structure is obtained with mainly lamellar morphology and higher hardness rate compared toinduction hardening or overlaying. Wear test of carbon steels revealed that plasma surfacing reduces abrasive wear rate compared to the irinitial state by 2 to 3 times. Enough sharp boundary between hardened and non-hardened portions has a positive effect on the performance of parts under dynamic loads, contributing to the inhibition of cracks during the transition from solid to a soft metal. For carbon and low alloy rail steels, the properties achieved by plasma surface hardening can effectively replace induction hardening or overlaying.The mode range for plasma surface treatment that allow sobtaining a surface layer with certain operating properties has been determined.

  15. A procedure for the hardening of materials

    International Nuclear Information System (INIS)

    Dearnaley, G.

    1984-01-01

    A method of hardening metals or ceramics which have fcc, bcc or hcp structures in which two species of differing atomic radii are introduced into the material to be hardened. One species is of a size such that it can diffuse through the lattice normally. The other is of a size such that it can diffuse readily only along dislocations. Ion bombardment is the preferred method of introducing the species with different atomic radii. The material to be hardened is subjected to heat and plastic deformation so as to cause a large number of dislocations with jogs. The species meet at the jogs where they interact and are trapped and set up strain fields which prevent further deformation of the material. (author)

  16. An Anisotropic Hardening Model for Springback Prediction

    Science.gov (United States)

    Zeng, Danielle; Xia, Z. Cedric

    2005-08-01

    As more Advanced High-Strength Steels (AHSS) are heavily used for automotive body structures and closures panels, accurate springback prediction for these components becomes more challenging because of their rapid hardening characteristics and ability to sustain even higher stresses. In this paper, a modified Mroz hardening model is proposed to capture realistic Bauschinger effect at reverse loading, such as when material passes through die radii or drawbead during sheet metal forming process. This model accounts for material anisotropic yield surface and nonlinear isotropic/kinematic hardening behavior. Material tension/compression test data are used to accurately represent Bauschinger effect. The effectiveness of the model is demonstrated by comparison of numerical and experimental springback results for a DP600 straight U-channel test.

  17. An Anisotropic Hardening Model for Springback Prediction

    International Nuclear Information System (INIS)

    Zeng, Danielle; Xia, Z. Cedric

    2005-01-01

    As more Advanced High-Strength Steels (AHSS) are heavily used for automotive body structures and closures panels, accurate springback prediction for these components becomes more challenging because of their rapid hardening characteristics and ability to sustain even higher stresses. In this paper, a modified Mroz hardening model is proposed to capture realistic Bauschinger effect at reverse loading, such as when material passes through die radii or drawbead during sheet metal forming process. This model accounts for material anisotropic yield surface and nonlinear isotropic/kinematic hardening behavior. Material tension/compression test data are used to accurately represent Bauschinger effect. The effectiveness of the model is demonstrated by comparison of numerical and experimental springback results for a DP600 straight U-channel test

  18. Radiation-hardened I2L 8*8 multiplier circuit

    International Nuclear Information System (INIS)

    Doyle, B.R.; Kreps, S.A.; Van Vonno, N.W.; Lake, G.W.

    1979-01-01

    Development of improved Substrate Fed I 2 L (SFL) processing has been combined with geometry and fanout constraints to design a radiation hardened LSI 8.8 Multiplier. This study describes details of the process and circuit design and gives resultant electrical and radiation test performance

  19. Novel circuits for radiation hardened memories

    International Nuclear Information System (INIS)

    Haraszti, T.P.; Mento, R.P.; Moyer, N.E.; Grant, W.M.

    1992-01-01

    This paper reports on implementation of large storage semiconductor memories which combine radiation hardness with high packing density, operational speed, and low power dissipation and require both hardened circuit and hardened process technologies. Novel circuits, including orthogonal shuffle type of write-read arrays, error correction by weighted bidirectional codes and associative iterative repair circuits, are proposed for significant improvements of SRAMs' immunity against the effects of total dose and cosmic particle impacts. The implementation of the proposed circuit resulted in fault-tolerant 40-Mbit and 10-Mbit monolithic memories featuring a data rate of 120 MHz and power dissipation of 880 mW. These experimental serial-parallel memories were fabricated with a nonhardened standard CMOS processing technology, yet provided a total dose hardness of 1 Mrad and a projected SEU rate of 1 x 10 - 12 error/bit/day. Using radiation hardened processing improvements by factors of 10 to 100 are predicted in both total dose hardness and SEU rate

  20. Improving precipitation hardening behavior of Mg−Zn based alloys with Ce−Ca microalloying additions

    Energy Technology Data Exchange (ETDEWEB)

    Langelier, B., E-mail: langelb@mcmaster.ca [Mechanical & Mechatronics Engineering, The University of Waterloo, N2L 3G1 (Canada); Canadian Centre for Electron Microscopy, McMaster University, L8S 4L8 (Canada); Korinek, A. [Canadian Centre for Electron Microscopy, McMaster University, L8S 4L8 (Canada); Donnadieu, P. [Univ. Grenoble Alpes, SIMAP, F-38000 Grenoble (France); CNRS, SIMAP, F-38000 Grenoble (France); Esmaeili, S. [Mechanical & Mechatronics Engineering, The University of Waterloo, N2L 3G1 (Canada)

    2016-10-15

    The precipitation hardening behavior of newly developed Mg−Zn−Ca−Ce alloys, with modified texture and improved ductility, is studied to delineate the microstructural characteristics that lead to effective hardening upon ageing treatments. Advanced electron microscopy and atom probe techniques are used to analyze the structural characteristics in relevance to the hardening potential. It has been found that the formation of a new basal precipitate phase, which evolves from a single atomic layer GP zone, and is finely distributed in both under-aged and peak-aged microstructures, has a significant impact in the improvement of the hardening response compared with the base Mg−Zn alloys. It has also been found that the β′{sub 1} rod precipitates, commonly formed during ageing treatments of Mg−Zn alloys, have their size and distribution significantly refined in the Ca−Ce containing alloys. The role of alloy chemistry in the formation of the fine basal plate GP zones and the refinement in β′{sub 1} precipitation and their relationships to the hardening behavior are discussed. It is proposed that Ca microalloying governs the formation of the GP zones and the enhancement of hardening, particularly in the under-aged conditions, but that this is aided by a beneficial effect from Ce. - Highlights: • Ce−Ca microalloying additions improve hardening in Mg−Zn, over Ce or Ca alone. • Improved hardening is due to refined β′{sub 1} rods, and fine basal plate precipitates. • Atom probe tomography identifies Ca in both β′{sub 1} and the fine basal plates. • The fine basal plates originate as ordered monolayer GP zones with 1:1 Zn:Ca (at.%). • With ageing GP zones become more Zn-rich and transform to the fine basal plates.

  1. ANISOTROPIC STRAIN-HARDENING IN POLYCRYSTALLINE COPPER AND ALUMINUM

    NARCIS (Netherlands)

    HESS, F

    1993-01-01

    A new viscoplastic model for the plastic stress-strain behaviour of f.c.c. metals is presented. In this model the strain hardening results from increasing dislocation densities. The observed stagnation of strain hardening after strain reversals is explained by a lowering of the increase in

  2. Surface hardening of titanium alloys with melting depth controlled by heat sink

    Science.gov (United States)

    Oden, Laurance L.; Turner, Paul C.

    1995-01-01

    A process for forming a hard surface coating on titanium alloys includes providing a piece of material containing titanium having at least a portion of one surface to be hardened. The piece having a portion of a surface to be hardened is contacted on the backside by a suitable heat sink such that the melting depth of said surface to be hardened may be controlled. A hardening material is then deposited as a slurry. Alternate methods of deposition include flame, arc, or plasma spraying, electrodeposition, vapor deposition, or any other deposition method known by those skilled in the art. The surface to be hardened is then selectively melted to the desired depth, dependent on the desired coating thickness, such that a molten pool is formed of the piece surface and the deposited hardening material. Upon cooling a hardened surface is formed.

  3. Research on SEU hardening of heterogeneous Dual-Core SoC

    Science.gov (United States)

    Huang, Kun; Hu, Keliu; Deng, Jun; Zhang, Tao

    2017-08-01

    The implementation of Single-Event Upsets (SEU) hardening has various schemes. However, some of them require a lot of human, material and financial resources. This paper proposes an easy scheme on SEU hardening for Heterogeneous Dual-core SoC (HD SoC) which contains three techniques. First, the automatic Triple Modular Redundancy (TMR) technique is adopted to harden the register heaps of the processor and the instruction-fetching module. Second, Hamming codes are used to harden the random access memory (RAM). Last, a software signature technique is applied to check the programs which are running on CPU. The scheme need not to consume additional resources, and has little influence on the performance of CPU. These technologies are very mature, easy to implement and needs low cost. According to the simulation result, the scheme can satisfy the basic demand of SEU-hardening.

  4. Altered Immune Cytokine Expression Associated with KoRV B Infection and Season in Captive Koalas

    Science.gov (United States)

    Higgins, Damien P.

    2016-01-01

    Koala (Phascolarctos cinereus) populations are increasingly vulnerable and one of the main threats is chlamydial infection. Koala retrovirus (KoRV) has been proposed as an underlying cause of the koala’s susceptibility to infection with Chlamydia and high rates of lymphoid neoplasia; however, the regionally ubiquitous, endogenous nature of this virus suggests that KoRV A infection is not sufficient for immune suppression to occur. A recently discovered exogenous variant of KoRV, KoRV B, has several structural elements that cause increased pathogenicity in related retroviruses and was associated with lymphoid neoplasia in one study. The present study assesses whether KoRV B infection is associated with alterations in immune function. Cytokine gene expression by mitogen stimulated lymphocytes of KoRV B positive (n = 5–6) and negative (n = 6–7) captive koalas was evaluated by qPCR four times (April 2014-February 2015) to control for seasonal variation. Key immune genes in the Th1 pathway (IFNγ, TNFα), Th2 pathway (IL 10, IL4, IL6) and Th17 pathway (IL17A), along with CD4:CD8 ratio, were assessed. KoRV B positive koalas showed significantly increased up-regulation of IL17A and IL10 in three out of four sampling periods and IFNγ, IL6, IL4 and TNFα in two out of four. IL17A is an immune marker for chlamydial pathogenesis in the koala; increased expression of IL17A in KoRV B positive koalas, and concurrent immune dysregulation, may explain the differences in susceptibility to chlamydial infection and severity of disease seen between individuals and populations. There was also marked seasonal variation in up-regulation for most of the cytokines and the CD4:CD8 ratio. The up-regulation in both Th1 and Th2 cytokines mirrors changes associated with immune dysregulation in humans and felids as a result of retroviral infections. This is the first report of altered immune expression in koalas infected by an exogenous variant of KoRV and also the first report of

  5. Hardening and softening mechanisms of pearlitic steel wire under torsion

    International Nuclear Information System (INIS)

    Zhao, Tian-Zhang; Zhang, Shi-Hong; Zhang, Guang-Liang; Song, Hong-Wu; Cheng, Ming

    2014-01-01

    Highlights: • Mechanical behavior of pearlitic steel wire is studied using torsion. • Work hardening results from refinement lamellar pearlitic structure. • Softening results from recovery, shear bands and lamellar fragmentations. • A microstructure based analytical flow stress model is established. - Abstract: The mechanical behaviors and microstructure evolution of pearlitic steel wires under monotonic shear deformation have been investigated by a torsion test and a number of electron microscopy techniques including scanning electron microscopy (SEM) and transmission electron microscopy (TEM), with an aim to reveal the softening and hardening mechanisms of a randomly oriented pearlitic structure during a monotonic stain path. Significantly different from the remarkable strain hardening in cold wire drawing, the strain hardening rate during torsion drops to zero quickly after a short hardening stage. The microstructure observations indicate that the inter-lamellar spacing (ILS) decreases and the dislocations accumulate with strain, which leads to hardening of the material. Meanwhile, when the strain is larger than 0.154, the enhancement of dynamic recovery, shear bands (SBs) and cementite fragmentations results in the softening and balances the strain hardening. A microstructure based analytical flow stress model with considering the influence of ILS on the mean free path of dislocations and the softening caused by SBs and cementite fragmentations, has been established and the predicted flow shear curve meets well with the measured curve in the torsion test

  6. The ORF59 DNA polymerase processivity factor homologs of Old World primate RV2 rhadinoviruses are highly conserved nuclear antigens expressed in differentiated epithelium in infected macaques

    Directory of Open Access Journals (Sweden)

    Burnside Kellie L

    2009-11-01

    Full Text Available Abstract Background ORF59 DNA polymerase processivity factor of the human rhadinovirus, Kaposi's sarcoma-associated herpesvirus (KSHV, is required for efficient copying of the genome during virus replication. KSHV ORF59 is antigenic in the infected host and is used as a marker for virus activation and replication. Results We cloned, sequenced and expressed the genes encoding related ORF59 proteins from the RV1 rhadinovirus homologs of KSHV from chimpanzee (PtrRV1 and three species of macaques (RFHVMm, RFHVMn and RFHVMf, and have compared them with ORF59 proteins obtained from members of the more distantly-related RV2 rhadinovirus lineage infecting the same non-human primate species (PtrRV2, RRV, MneRV2, and MfaRV2, respectively. We found that ORF59 homologs of the RV1 and RV2 Old World primate rhadinoviruses are highly conserved with distinct phylogenetic clustering of the two rhadinovirus lineages. RV1 and RV2 ORF59 C-terminal domains exhibit a strong lineage-specific conservation. Rabbit antiserum was developed against a C-terminal polypeptide that is highly conserved between the macaque RV2 ORF59 sequences. This anti-serum showed strong reactivity towards ORF59 encoded by the macaque RV2 rhadinoviruses, RRV (rhesus and MneRV2 (pig-tail, with no cross reaction to human or macaque RV1 ORF59 proteins. Using this antiserum and RT-qPCR, we determined that RRV ORF59 is expressed early after permissive infection of both rhesus primary fetal fibroblasts and African green monkey kidney epithelial cells (Vero in vitro. RRV- and MneRV2-infected foci showed strong nuclear expression of ORF59 that correlated with production of infectious progeny virus. Immunohistochemical studies of an MneRV2-infected macaque revealed strong nuclear expression of ORF59 in infected cells within the differentiating layer of epidermis corroborating previous observations that differentiated epithelial cells are permissive for replication of KSHV-like rhadinoviruses

  7. EFFECT OF HARDENING TIME ON DEFORMATION-STRENGTH INDICATORS OF CONCRETE FOR INJECTION WITH A TWO-STAGE EXPANSION DURING HARDENING IN WATER

    Directory of Open Access Journals (Sweden)

    Tatjana N. Zhilnikova

    2017-01-01

    Full Text Available Abstract. Objectives Concretes for injection with a two-stage expansion are a kind of selfstressing concrete obtained with the use of self-stressing cement.The aim of the work is to study the influence of the duration of aging on the porosity, strength and self-stress of concrete hardening in water, depending on the expansion value at the first stage. At the first stage, the compacted concrete mixture is expanded to ensure complete filling of the formwork space. At the second stage, the hardening concrete expands due to the formation of an increased amount of ettringite. This process is prolonged in time, with the amount of self-stress and strength dependant on the conditions of hardening. Methods  Experimental evaluation of self-stress, strength and porosity of concretes that are permanently hardened in water, under air-moist and air-dry conditions after different expansion at the first stage. The self-stress of cement stone is the result of superposition of two processes: the hardening of the structure due to hydration of silicates and its expansion as a result of hydration of calcium aluminates with the subsequent formation of ettringite. The magnitude of self-stress is determined by the ratio of these two processes. The self-stress of the cement stone changes in a manner similar to the change in its expansion. The stabilisation of expansion is accompanied by stabilisation of self-stress of cement stone. Results  The relationship of self-stress, strength and porosity of concrete for injection with a two-stage expansion on the duration and humidity conditions of hardening, taking into account the conditions of deformation limitation at the first stage, is revealed. Conclusion During prolonged hardening in an aqueous medium, self-stresses are reduced up to 25% with the exception of expansion at the first stage and up to 20% with an increase in volume up to 5% at the first stage. The increase in compressive strength is up to 28% relative to

  8. Design Features of Hardening Turners with Outstripping Plastic Deformation

    Directory of Open Access Journals (Sweden)

    V. M. Yaroslavtsev

    2014-01-01

    Full Text Available An efficiency of the cutting method with outstripping plastic deformation (OPD in lathe works is defined in many respects by design features of the add-on devices for mechanical hardening of a cut-off layer material in the course of cutting. Applied on lathes, deforming OPD devices can have differing dimensions, placement on the lathe, drive type (manual, electric, hydraulic, pneumatic, pneumohydraulic, electromagnetic, and autonomy degree towards the metalcutting equipment and industrial equipment.At the same time there are a number of inherent design features of work-hardening devices the modernized lathes with OPD use for machining. Now the OPD standard devices implement two principle construction options: loading device is placed on the machine or on the OPD slide support separate of the tool, or it is structurally aligned with the cutting tool. In the latter case the OPD device for turning is called a tool mandrel, which is mounted in a tool post of the machine or, at large dimensions, such a mandrel is mounted on the machine instead of the tool mandrel.When designing the OPD devices, is important to take into consideration production requirements and recommendations for the technological equipment, developed in the course of creation, working off and introduction of such installations for mechanical hardening of material. In compliance with it, OPD devices, their placement on the machine, and working displacements shouldn't limit technological capabilities of the applied metal-cutting equipment. OPD stresses have to be smoothly regulated, with maximum loads being limited to admissible values for the machine model to be modernized. It is necessary to ensure synchronized longitudinal and cross displacements of the cutting tool and OPD hardener with respect to the axis of billet rotation to enable regulation and readjustment of the hardener and tool placement. It ought to foresee the increased mobile components rigidity and manufacturing

  9. Cellular Composites with Ambient and Autoclaved Type of Hardening with Application of Nanostructured Binder

    International Nuclear Information System (INIS)

    Nelyubova, V; Pavlenko, N; Netsvet, D

    2015-01-01

    The research presents the dimensional and structural characteristics of nonhydrational hardening binders - nanostructured binders. Rational areas of their use in composites for construction purposes are given. The paper presents the results of the development of natural hardening foam concrete and aerated autoclaved concrete for thermal insulating and construction and thermal insulating purposes. Thus nanostructured binder (NB) in the composites was used as a primary binder and a high reactive modifier. (paper)

  10. Radiation hardening of semiconductor parts

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    This chapter is an overview of total-ionizing-dose and single-event hardening techniques and should be used as a guide to a range of research publications. It should be stressed that there is no clear and simple route to a radiation-tolerant silicon integrated circuit. What works for one fabrication process may not work for another, and there are many complex interactions within individual processes and designs. The authors have attempted to highlight the most important factors and those process changes which should bring improved hardness. The main point is that radiation-hardening as a procedure must be approached in a methodical fashion and with a good understanding of the response mechanisms involved

  11. Energetic model of metal hardening

    Directory of Open Access Journals (Sweden)

    Ignatova O.N.

    2011-01-01

    Full Text Available Based on Bailey hypothesis on the link between strain hardening and elastic lattice defect energy this paper suggests a shear strength energetic model that takes into consideration plastic strain intensity and rate as well as softening related to temperature annealing and dislocation annihilation. Metal strain hardening was demonstrated to be determined only by elastic strain energy related to the energy of accumulated defects. It is anticipated that accumulation of the elastic energy of defects is governed by plastic work. The suggested model has a reasonable agreement with the available experimental data for copper up to P = 70 GPa , for aluminum up to P = 10 GPa and for tantalum up to P = 20 GPa.

  12. Crystallization and preliminary X-ray analysis of a novel esterase Rv0045c from Mycobacterium tuberculosis

    International Nuclear Information System (INIS)

    Xu, Lipeng; Guo, Jiubiao; Zheng, Xiangdong; Wen, Tingyi; Sun, Fei; Liu, Siguo; Pang, Hai

    2010-01-01

    The novel esterase Rv0045c from M. tuberculosis was expressed and purified to homogeneity. The crystals of native and SeMet-labelled Rv0045c protein that were obtained diffracted to resolutions of 2.7 and 3.0 Å, respectively. The Rv0045c protein is predicted to be an esterase that is involved in lipid metabolism in Mycobacterium tuberculosis. The protein was overproduced in Escherichia coli, purified and crystallized using the hanging-drop vapour-diffusion method. The Rv0045c protein crystals diffracted to a resolution of 2.7 Å using a synchrotron-radiation source and belonged to space group P3 1 or P3 2 , with unit-cell parameters a = b = 73.465, c = 48.064 Å, α = β = 90, γ = 120°. Purified SeMet-labelled Rv0045c protein was also crystallized and formed crystals that diffracted to a resolution of 3.0 Å using an in-house X-ray radiation source

  13. Modeling and Analysis of Deformation for Spiral Bevel Gear in Die Quenching Based on the Hardenability Variation

    Science.gov (United States)

    Zhang, Yingtao; Wang, Gang; Shi, Wankai; Yang, Lin; Li, Zhichao

    2017-07-01

    Spiral bevel gears are widely used to transmit energy between intersecting axes. The strength and fatigue life of the gears are improved by carburizing and quenching. A die quenching process is used to control the deformation of the gear. The deformation is determined by the variations in the hardenability for a certain die quenching process. The relationship between hardenability, phase transformation and deformation needs to be studied to minimize deformation during the adjustment of the die quenching process parameters. In this paper, material properties for 22CrMoH steel are determined by the results of Jominy tests, dilatometry experiments and static mechanical property tests. The material models were built based on testing results under the consideration of hardenability variation. An finite element analysis model was developed to couple the phase transformation and deformation history of the complete carburizing and die quenching process for the spiral bevel gears. The final microstructures in the gear were bainite for low hardenability steel and a mixture of bainite and ferrite for high hardenability steel. The largest buckling deformation at the gear bottom surface is 0.375 mm at the outer circle for the low hardenability gear and 0.091 mm at the inner circle for the high hardenability gear.

  14. Nonlinear kinematic hardening under non-proportional loading

    International Nuclear Information System (INIS)

    Ottosen, N.S.

    1979-07-01

    Within the framework of conventional plasticity theory, it is first determined under which conditions Melan-Prager's and Ziegler's kinematic hardening rules result in identical material behaviour. Next, assuming initial isotropy and adopting the von Mises yield criterion, a nonlinear kinematic hardening function is proposed for prediction of metal behaviour. The model assumes that hardening at a specific stress point depends on the direction of the new incremental loading. Hereby a realistic response is obtained for general reversed loading, and a smooth behaviour is assured, even when loading deviates more and more from proportional loading and ultimately results in reversed loading. The predictions of the proposed model for non-proportional loading under plane stress conditions are compared with those of the classical linear kinematic model, the isotropic model and with published experimental data. Finally, the limitations of the proposaed model are discussed. (author)

  15. Hardening cookies in web-based systems for better system integrity

    International Nuclear Information System (INIS)

    Mohamad Safuan Sulaiman; Mohd Dzul Aiman Aslan; Saaidi Ismail; Abdul Aziz Mohd Ramli; Abdul Muin Abdul Rahman; Siti Nurbahyah Hamdan; Norlelawati Hashimuddin; Sufian Norazam Mohamed Aris

    2012-01-01

    IT Center (ITC) as technical support and provider for most of web-based systems in Nuclear Malaysia has conducted a study to investigate cookie vulnerability in a system for better integrity. A part of the result has found that cookies in a web-based system in Nuclear Malaysia can be easily manipulated. The main objective of the study is to harden the vulnerability of the cookies. Two levels of security procedures have been used and enforced which consist of 1) Penetration test (Pen Test) 2) Hardening procedure. In one of the system, study has found that 121 attempts threats have been detected after the hardening enforcement from 23 March till 20 September 2012. At this stage, it can be concluded that cookie vulnerability in the system has been hardened and integrity has been assured after the enforcement. This paper describes in detail the penetration and hardening process of cookie vulnerability for better supporting web-based system in Nuclear Malaysia. (author)

  16. The effect of initial microstructure on the final properties of press hardened 22MnB5 steels

    International Nuclear Information System (INIS)

    Järvinen, Henri; Isakov, Matti; Nyyssönen, Tuomo; Järvenpää, Martti; Peura, Pasi

    2016-01-01

    This paper addresses the relationship between initial microstructure and final properties of press hardened 22MnB5 steels. Four commercial 22MnB5 steels having different initial microstructures were investigated. An experimental press hardening equipment with a flat-die was used to investigate material behavior in the direct press hardening process. Two austenitizing treatments, 450 s and 180 s at 900 °C, were examined. Microstructural characterization with optical and scanning electron microscopes revealed a mixture of martensite and auto-tempered martensite after press hardening. Electron backscatter diffraction data of the transformed martensite was used to reconstruct grain boundary maps of parent austenite. Grain sizes of parent austenite (mean linear intercept) were measured for each material. In addition to microstructural evaluation, quasistatic and high strain rate tensile tests at strain rates of 5×10 −4 s −1 and 400 s −1 , respectively, were performed for press hardened samples. The results show that strength and uniform elongation depend on the initial microstructure of the 22MnB5 steel, when parameters typical to the direct press hardening process are used. Parent austenite grain size was shown to influence the morphology of the transformed martensite, which in turn affects the strength and uniform elongation after press hardening. The tensile properties of the press hardened materials are almost strain rate independent in the studied strain rate range. The obtained results can be used to optimize the properties of 22MnB5 steels in the direct press hardening process. In addition, the here revealed connection between the parent austenite grain size and final steel properties should be taken into account in the development of new press hardening steel grades for automotive industry.

  17. The effect of initial microstructure on the final properties of press hardened 22MnB5 steels

    Energy Technology Data Exchange (ETDEWEB)

    Järvinen, Henri, E-mail: henri.jarvinen@tut.fi [Department of Materials Science, Tampere University of Technology, P.O.Box 589, FI-33101 Tampere (Finland); Isakov, Matti; Nyyssönen, Tuomo [Department of Materials Science, Tampere University of Technology, P.O.Box 589, FI-33101 Tampere (Finland); Järvenpää, Martti [SSAB Europe Oy, Harvialantie 420, FI-13300 Hämeenlinna (Finland); Peura, Pasi [Department of Materials Science, Tampere University of Technology, P.O.Box 589, FI-33101 Tampere (Finland)

    2016-10-31

    This paper addresses the relationship between initial microstructure and final properties of press hardened 22MnB5 steels. Four commercial 22MnB5 steels having different initial microstructures were investigated. An experimental press hardening equipment with a flat-die was used to investigate material behavior in the direct press hardening process. Two austenitizing treatments, 450 s and 180 s at 900 °C, were examined. Microstructural characterization with optical and scanning electron microscopes revealed a mixture of martensite and auto-tempered martensite after press hardening. Electron backscatter diffraction data of the transformed martensite was used to reconstruct grain boundary maps of parent austenite. Grain sizes of parent austenite (mean linear intercept) were measured for each material. In addition to microstructural evaluation, quasistatic and high strain rate tensile tests at strain rates of 5×10{sup −4} s{sup −1} and 400 s{sup −1}, respectively, were performed for press hardened samples. The results show that strength and uniform elongation depend on the initial microstructure of the 22MnB5 steel, when parameters typical to the direct press hardening process are used. Parent austenite grain size was shown to influence the morphology of the transformed martensite, which in turn affects the strength and uniform elongation after press hardening. The tensile properties of the press hardened materials are almost strain rate independent in the studied strain rate range. The obtained results can be used to optimize the properties of 22MnB5 steels in the direct press hardening process. In addition, the here revealed connection between the parent austenite grain size and final steel properties should be taken into account in the development of new press hardening steel grades for automotive industry.

  18. Purification, crystallization and preliminary X-ray crystallographic studies of Rv3705c from Mycobacterium tuberculosis

    International Nuclear Information System (INIS)

    Lu, Feifei; Gao, Feng; Li, Honglin; Gong, Weimin; Zhou, Lin; Bi, Lijun

    2014-01-01

    The cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of Rv3705c from M. tuberculosis are described. The conserved protein Rv3705c from Mycobacterium tuberculosis has been cloned, expressed, purified and crystallized by the sitting-drop vapour-diffusion method using PEG 3350 as a precipitant. The Rv3705c crystals exhibited space group P6 1 22 or P6 5 22, with unit-cell parameters a = b = 198.0, c = 364.1 Å, α = β = 90, γ = 120°, and diffracted to a resolution of 3.3 Å

  19. Purification, crystallization and preliminary X-ray crystallographic studies of Rv3705c from Mycobacterium tuberculosis

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Feifei [East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People’s Republic of (China); Gao, Feng [Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, People’s Republic of (China); Li, Honglin [East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People’s Republic of (China); Gong, Weimin [Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, People’s Republic of (China); Zhou, Lin, E-mail: gdtb-bg@vip.163.com [Center for Tuberculosis Control of Guangdong Province, Guangzhou, People’s Republic of (China); Bi, Lijun, E-mail: gdtb-bg@vip.163.com [East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People’s Republic of (China)

    2014-07-23

    The cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of Rv3705c from M. tuberculosis are described. The conserved protein Rv3705c from Mycobacterium tuberculosis has been cloned, expressed, purified and crystallized by the sitting-drop vapour-diffusion method using PEG 3350 as a precipitant. The Rv3705c crystals exhibited space group P6{sub 1}22 or P6{sub 5}22, with unit-cell parameters a = b = 198.0, c = 364.1 Å, α = β = 90, γ = 120°, and diffracted to a resolution of 3.3 Å.

  20. Process design of press hardening with gradient material property influence

    International Nuclear Information System (INIS)

    Neugebauer, R.; Schieck, F.; Rautenstrauch, A.

    2011-01-01

    Press hardening is currently used in the production of automotive structures that require very high strength and controlled deformation during crash tests. Press hardening can achieve significant reductions of sheet thickness at constant strength and is therefore a promising technology for the production of lightweight and energy-efficient automobiles. The manganese-boron steel 22MnB5 have been implemented in sheet press hardening owing to their excellent hot formability, high hardenability, and good temperability even at low cooling rates. However, press-hardened components have shown poor ductility and cracking at relatively small strains. A possible solution to this problem is a selective increase of steel sheet ductility by press hardening process design in areas where the component is required to deform plastically during crash tests. To this end, process designers require information about microstructure and mechanical properties as a function of the wide spectrum of cooling rates and sequences and austenitizing treatment conditions that can be encountered in production environments. In the present work, a Continuous Cooling Transformation (CCT) diagram with corresponding material properties of sheet steel 22MnB5 was determined for a wide spectrum of cooling rates. Heating and cooling programs were conducted in a quenching dilatometer. Motivated by the importance of residual elasticity in crash test performance, this property was measured using a micro-bending test and the results were integrated into the CCT diagrams to complement the hardness testing results. This information is essential for the process design of press hardening of sheet components with gradient material properties.

  1. Kinematic Hardening: Characterization, Modeling and Impact on Springback Prediction

    International Nuclear Information System (INIS)

    Alves, J. L.; Bouvier, S.; Jomaa, M.; Billardon, R.; Oliveira, M. C.; Menezes, L. F.

    2007-01-01

    The constitutive modeling of the materials' mechanical behavior, usually carried out using a phenomenological constitutive model, i.e., a yield criterion associated to the isotropic and kinematic hardening laws, is of paramount importance in the FEM simulation of the sheet metal forming processes, as well as in the springback prediction. Among others, the kinematic behavior of the yield surface plays an essential role, since it is indispensable to describe the Bauschinger effect, i.e., the materials' answer to the multiple tension-compression cycles to which material points are submitted during the forming process. Several laws are usually used to model and describe the kinematic hardening, namely: a) the Prager's law, which describes a linear evolution of the kinematic hardening with the plastic strain rate tensor b) the Frederick-Armstrong non-linear kinematic hardening, basically a non-linear law with saturation; and c) a more advanced physically-based law, similar to the previous one but sensitive to the strain path changes. In the present paper a mixed kinematic hardening law (linear + non-linear behavior) is proposed and its implementation into a static fully-implicit FE code is described. The material parameters identification for sheet metals using different strategies, and the classical Bauschinger loading tests (i.e. in-plane forward and reverse monotonic loading), are addressed, and their impact on springback prediction evaluated. Some numerical results concerning the springback prediction of the Numisheet'05 Benchmark no. 3 are briefly presented to emphasize the importance of a correct modeling and identification of the kinematic hardening behavior

  2. Latent hardening size effect in small-scale plasticity

    Science.gov (United States)

    Bardella, Lorenzo; Segurado, Javier; Panteghini, Andrea; Llorca, Javier

    2013-07-01

    We aim at understanding the multislip behaviour of metals subject to irreversible deformations at small-scales. By focusing on the simple shear of a constrained single-crystal strip, we show that discrete Dislocation Dynamics (DD) simulations predict a strong latent hardening size effect, with smaller being stronger in the range [1.5 µm, 6 µm] for the strip height. We attempt to represent the DD pseudo-experimental results by developing a flow theory of Strain Gradient Crystal Plasticity (SGCP), involving both energetic and dissipative higher-order terms and, as a main novelty, a strain gradient extension of the conventional latent hardening. In order to discuss the capability of the SGCP theory proposed, we implement it into a Finite Element (FE) code and set its material parameters on the basis of the DD results. The SGCP FE code is specifically developed for the boundary value problem under study so that we can implement a fully implicit (Backward Euler) consistent algorithm. Special emphasis is placed on the discussion of the role of the material length scales involved in the SGCP model, from both the mechanical and numerical points of view.

  3. Latent hardening size effect in small-scale plasticity

    International Nuclear Information System (INIS)

    Bardella, Lorenzo; Panteghini, Andrea; Segurado, Javier; Llorca, Javier

    2013-01-01

    We aim at understanding the multislip behaviour of metals subject to irreversible deformations at small-scales. By focusing on the simple shear of a constrained single-crystal strip, we show that discrete Dislocation Dynamics (DD) simulations predict a strong latent hardening size effect, with smaller being stronger in the range [1.5 µm, 6 µm] for the strip height. We attempt to represent the DD pseudo-experimental results by developing a flow theory of Strain Gradient Crystal Plasticity (SGCP), involving both energetic and dissipative higher-order terms and, as a main novelty, a strain gradient extension of the conventional latent hardening. In order to discuss the capability of the SGCP theory proposed, we implement it into a Finite Element (FE) code and set its material parameters on the basis of the DD results. The SGCP FE code is specifically developed for the boundary value problem under study so that we can implement a fully implicit (Backward Euler) consistent algorithm. Special emphasis is placed on the discussion of the role of the material length scales involved in the SGCP model, from both the mechanical and numerical points of view. (paper)

  4. Reduction of metal artifacts: beam hardening and photon starvation effects

    Science.gov (United States)

    Yadava, Girijesh K.; Pal, Debashish; Hsieh, Jiang

    2014-03-01

    The presence of metal-artifacts in CT imaging can obscure relevant anatomy and interfere with disease diagnosis. The cause and occurrence of metal-artifacts are primarily due to beam hardening, scatter, partial volume and photon starvation; however, the contribution to the artifacts from each of them depends on the type of hardware. A comparison of CT images obtained with different metallic hardware in various applications, along with acquisition and reconstruction parameters, helps understand methods for reducing or overcoming such artifacts. In this work, a metal beam hardening correction (BHC) and a projection-completion based metal artifact reduction (MAR) algorithms were developed, and applied on phantom and clinical CT scans with various metallic implants. Stainless-steel and Titanium were used to model and correct for metal beam hardening effect. In the MAR algorithm, the corrupted projection samples are replaced by the combination of original projections and in-painted data obtained by forward projecting a prior image. The data included spine fixation screws, hip-implants, dental-filling, and body extremity fixations, covering range of clinically used metal implants. Comparison of BHC and MAR on different metallic implants was used to characterize dominant source of the artifacts, and conceivable methods to overcome those. Results of the study indicate that beam hardening could be a dominant source of artifact in many spine and extremity fixations, whereas dental and hip implants could be dominant source of photon starvation. The BHC algorithm could significantly improve image quality in CT scans with metallic screws, whereas MAR algorithm could alleviate artifacts in hip-implants and dentalfillings.

  5. Sedimentary record of heavy metals in Lake Rõuge Liinjärv, southern Estonia

    Directory of Open Access Journals (Sweden)

    Lepane, Viia

    2007-12-01

    Full Text Available Anthropogenic impact on Lake Liinjärv (Rõuge, southern Estonia was studied back to the mid-19th century on the basis of heavy metals (Pb, Cu, Zn, Mn, and Hg and geochemical parameters of a short sediment core dated by 210Pb isotopes. The development of the lake and its sediment composition are heavily influenced by the inflow of saturated calcareous waters that cause precipitation of calcium carbonates. The concentrations of most of the metals started to increase at the end of the 1970s. This is most clearly observable for Zn, Cu, and Pb. At the same time the distribution pattern of Mn seems to be controlled mainly by the redox conditions in the hypolimneon. The main sources of pollutants in Lake Liinjärv, due to its large catchment area, are the influence of agricultural activity and atmospheric input. Organic matter is the main factor affecting heavy metal (Pb, Hg, Cu, and Zn distribution in lake sediments.

  6. Cardiac magnetic resonance markers of progressive RV dilation and dysfunction after tetralogy of Fallot repair

    NARCIS (Netherlands)

    Wald, Rachel M.; Valente, Anne Marie; Gauvreau, Kimberlee; Babu-Narayan, Sonya V.; Assenza, Gabriele Egidy; Schreier, Jenna; Gatzoulis, Michael A.; Kilner, Philip J.; Koyak, Zeliha; Mulder, Barbara; Powell, Andrew J.; Geva, Tal

    2015-01-01

    Patients with repaired tetralogy of Fallot (TOF) are followed serially by cardiac magnetic resonance (CMR) for surveillance of RV dilation and dysfunction. We sought to define the prevalence of progressive RV disease and the optimal time interval between CMR evaluations. Candidates were selected

  7. A project of X-ray hardening correction in large ICT

    International Nuclear Information System (INIS)

    Fang Min; Liu Yinong; Ni Jianping

    2005-01-01

    This paper presents a means of polychromatic X-ray beam hardening correction using a standard function to transform the polychromatic projection to monochromatic projection in large Industrial Computed Tomography (ICT). Some parameters were defined to verify the validity of hardening correction in large ICT and optimized. Simulated experiments were used to prove that without prior knowledge of the composition of the scanned object, the correction method using monochromatic reconstruction arithmetic could remove beam hardening artifact greatly. (authors)

  8. Influence of Hardening Model on Weld Residual Stress Distribution

    Energy Technology Data Exchange (ETDEWEB)

    Mullins, Jonathan; Gunnars, Jens (Inspecta Technology AB, Stockholm (Sweden))

    2009-06-15

    This study is the third stage of a project sponsored by the Swedish Radiation Safety Authority (SSM) to improve the weld residual stress modelling procedures currently used in Sweden. The aim of this study was to determine which material hardening model gave the best agreement with experimentally measured weld residual stress distributions. Two girth weld geometries were considered: 19mm and 65mm thick girth welds with Rin/t ratios of 10.5 and 2.8, respectively. The FE solver ABAQUS Standard v6.5 was used for analysis. As a preliminary step some improvements were made to the welding simulation procedure used in part one of the project. First, monotonic stress strain curves and a mixed isotropic/kinematic hardening model were sourced from the literature for 316 stainless steel. Second, more detailed information was obtained regarding the geometry and welding sequence for the Case 1 weld (compared with phase 1 of this project). Following the preliminary step, welding simulations were conducted using isotropic, kinematic and mixed hardening models. The isotropic hardening model gave the best overall agreement with experimental measurements; it is therefore recommended for future use in welding simulations. The mixed hardening model gave good agreement for predictions of the hoop stress but tended to under estimate the magnitude of the axial stress. It must be noted that two different sources of data were used for the isotropic and mixed models in this study and this may have contributed to the discrepancy in predictions. When defining a mixed hardening model it is difficult to delineate the relative contributions of isotropic and kinematic hardening and for the model used it may be that a greater isotropic hardening component should have been specified. The kinematic hardening model consistently underestimated the magnitude of both the axial and hoop stress and is not recommended for use. Two sensitivity studies were also conducted. In the first the effect of using a

  9. Influence of Hardening Model on Weld Residual Stress Distribution

    International Nuclear Information System (INIS)

    Mullins, Jonathan; Gunnars, Jens

    2009-06-01

    This study is the third stage of a project sponsored by the Swedish Radiation Safety Authority (SSM) to improve the weld residual stress modelling procedures currently used in Sweden. The aim of this study was to determine which material hardening model gave the best agreement with experimentally measured weld residual stress distributions. Two girth weld geometries were considered: 19mm and 65mm thick girth welds with Rin/t ratios of 10.5 and 2.8, respectively. The FE solver ABAQUS Standard v6.5 was used for analysis. As a preliminary step some improvements were made to the welding simulation procedure used in part one of the project. First, monotonic stress strain curves and a mixed isotropic/kinematic hardening model were sourced from the literature for 316 stainless steel. Second, more detailed information was obtained regarding the geometry and welding sequence for the Case 1 weld (compared with phase 1 of this project). Following the preliminary step, welding simulations were conducted using isotropic, kinematic and mixed hardening models. The isotropic hardening model gave the best overall agreement with experimental measurements; it is therefore recommended for future use in welding simulations. The mixed hardening model gave good agreement for predictions of the hoop stress but tended to under estimate the magnitude of the axial stress. It must be noted that two different sources of data were used for the isotropic and mixed models in this study and this may have contributed to the discrepancy in predictions. When defining a mixed hardening model it is difficult to delineate the relative contributions of isotropic and kinematic hardening and for the model used it may be that a greater isotropic hardening component should have been specified. The kinematic hardening model consistently underestimated the magnitude of both the axial and hoop stress and is not recommended for use. Two sensitivity studies were also conducted. In the first the effect of using a

  10. [Microstructural changes in hardened beans (Phaseolus vulgaris)].

    Science.gov (United States)

    Mujica, Maria Virginia; Granito, Marisela; Soto, Naudy

    2015-06-01

    (Phaseolus vulgaris). The hardening of Phaseolus vulgaris beans stored at high temperature and high relative humidity is one of the main constraints for consumption. The objective of this research was to evaluate by scanning electron microscopy, structural changes in cotyledons and testa of the hardened beans. The freshly harvested grains were stored for twelve months under two conditions: 5 ° C-34% RH and 37 ° C-75% RH, in order to promote hardening. The stored raw and cooked grains were lyophilized and fractured. The sections of testa and cotyledons were observed in an electron microscope JSM-6390. After twelve months, grains stored at 37 ° C-75% RH increased their hardness by 503%, whereas there were no significant changes in grains stored at 5 ° C-34% RH. At the microstructural level, the cotyledons of the raw grains show clear differences in appearance of the cell wall, into the intercellular space size and texture matrix protein. There were also differences in compaction of palisade and sub-epidermal layer in the testa of raw grains. After cooking, cotyledon cells of the soft grains were well separated while these ofhard grains were seldom separated. In conclusion, the found differences in hard and soft grains showed a significant participation of both structures, cotyledons and testa, in the grains hardening.

  11. A Study on the Marketing Strategy of RV Travel in China%国内房车旅游营销策略研究

    Institute of Scientific and Technical Information of China (English)

    梁磊

    2011-01-01

    With the advent of experience economy, RV travel is increasingly welcomed as a fashionable way to travel. At present, the domestic RV tourism development is far behind the developed countries, and there exist such problems as delayed construction of camping and related facilities, the inadequate consumption capacity, the inadequate RV tourism marketing and delayed tourism facilities and services. To solve these problems, this paper puts forward some marketing strategies, including carrying out camp marketing, subdividing RV tourism market, strengthening cooperation among related industries and enterprises, improving ways and means of RV tourism information dissemination, and promoting the construction of RV rental network.%随着体验经济时代的到来,房车旅游作为一种时尚的旅游方式日益受到人们的青睐。当前,国内房车旅游发展远远落后于发达国家,并存在露营地及相关设施建设滞后、居民消费能力不足、房车旅游营销力度不够和房车旅游设施及服务滞后的问题,针对这些问题,提出开展营地营销、细分房车旅游市场、加强房车旅游相关行业企业之间的合作、优化房车旅游信息传播方式和手段、加强房车租赁网络建设的房车旅游具体营销策略。

  12. Concrete, hardened: Self desiccation

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan De Place; Hansen, Kurt Kielsgaard; Persson, Bertil

    1999-01-01

    The test method covers the determination of internal relative humidity (RH) in hardened concrete and cement mortar using RH instruments. The determination of RH is done on crushed samples of concrete or cement motar. This test method is only for measuring equipment which gives off or takes up...

  13. Inhibition of apoptosis by Rv2456c through nuclear factor-κB extends the survival of Mycobacterium tuberculosis

    Directory of Open Access Journals (Sweden)

    Kristen L. Jurcic Smith

    2016-01-01

    Full Text Available Mycobacterium tuberculosis, the causative agent of tuberculosis, is an intracellular pathogen with several survival mechanisms aimed at subverting the host immune system. Apoptosis has been shown to be mycobactericidal, to activate CD8+ T cells, and to be modulated by mycobacterial proteins. Since few mycobacterial proteins have so far been directly implicated in the interactions between M. Tuberculosis and host cell apoptosis, we screened M. Tuberculosis H37Rv transposon mutants to identify mutants that fail to inhibit cell death (FID. One of these FID mutants, FID19, had a transposon insertion in Rv2456c and is important for survival in host cells. The lack of the protein resulted in enhanced caspase-3 mediated apoptosis, which is probably due to an inability to activate nuclear factor-κB. Additionally, FID19 infection enhanced polyfunctional CD8+ T cells and induced a higher frequency of interferon-γ secreting immune cells in a murine model. Taken together, our data suggest that Rv2456c is important for the survival of H37Rv by subduing the innate and ultimately adaptive immune responses of its host by preventing apoptosis of the infected cell. Better understanding of the host-mycobacterial interactions may be beneficial to develop novel drug targets and engineer more efficacious vaccine strains against tuberculosis.

  14. High temperature, radiation hardened electronics for application to nuclear power plants

    International Nuclear Information System (INIS)

    Gover, J.E.

    1980-01-01

    Electronic circuits were developed and built at Sandia for many aerospace and energy systems applications. Among recent developments were high temperature electronics for geothermal well logging and radiation hardened electronics for a variety of aerospace applications. Sandia has also been active in technology transfer to commercial industry in both of these areas

  15. Beam hardening correction algorithm in microtomography images

    International Nuclear Information System (INIS)

    Sales, Erika S.; Lima, Inaya C.B.; Lopes, Ricardo T.; Assis, Joaquim T. de

    2009-01-01

    Quantification of mineral density of bone samples is directly related to the attenuation coefficient of bone. The X-rays used in microtomography images are polychromatic and have a moderately broad spectrum of energy, which makes the low-energy X-rays passing through a sample to be absorbed, causing a decrease in the attenuation coefficient and possibly artifacts. This decrease in the attenuation coefficient is due to a process called beam hardening. In this work the beam hardening of microtomography images of vertebrae of Wistar rats subjected to a study of hyperthyroidism was corrected by the method of linearization of the projections. It was discretized using a spectrum in energy, also called the spectrum of Herman. The results without correction for beam hardening showed significant differences in bone volume, which could lead to a possible diagnosis of osteoporosis. But the data with correction showed a decrease in bone volume, but this decrease was not significant in a confidence interval of 95%. (author)

  16. Beam hardening correction algorithm in microtomography images

    Energy Technology Data Exchange (ETDEWEB)

    Sales, Erika S.; Lima, Inaya C.B.; Lopes, Ricardo T., E-mail: esales@con.ufrj.b, E-mail: ricardo@lin.ufrj.b [Coordenacao dos Programas de Pos-graduacao de Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Lab. de Instrumentacao Nuclear; Assis, Joaquim T. de, E-mail: joaquim@iprj.uerj.b [Universidade do Estado do Rio de Janeiro (UERJ), Nova Friburgo, RJ (Brazil). Inst. Politecnico. Dept. de Engenharia Mecanica

    2009-07-01

    Quantification of mineral density of bone samples is directly related to the attenuation coefficient of bone. The X-rays used in microtomography images are polychromatic and have a moderately broad spectrum of energy, which makes the low-energy X-rays passing through a sample to be absorbed, causing a decrease in the attenuation coefficient and possibly artifacts. This decrease in the attenuation coefficient is due to a process called beam hardening. In this work the beam hardening of microtomography images of vertebrae of Wistar rats subjected to a study of hyperthyroidism was corrected by the method of linearization of the projections. It was discretized using a spectrum in energy, also called the spectrum of Herman. The results without correction for beam hardening showed significant differences in bone volume, which could lead to a possible diagnosis of osteoporosis. But the data with correction showed a decrease in bone volume, but this decrease was not significant in a confidence interval of 95%. (author)

  17. Evaluation of hardening by ion irradiation in molybdenum using nanoindentation techniques

    International Nuclear Information System (INIS)

    Iwakiri, Hirotomi; Watanabe, Hideo; Yoshida, Naoaki

    1997-01-01

    As a part of fundamental research on interaction of plasma and wall, some model experiments on loading of particles such as He, H and so forth suffered by plasma facing material were conducted for Mo in high Z material. As an evaluation method for it, nanoindentation technique was proposed. By this method, the hardness evaluation in surface neighboring damage range was conducted. As a result, in the helium irradiated materials, sufficient hardening was observed even at low dpa range impossible to recognize hardening on heavy ion and deuterium irradiated materials, and extreme hardening was established by formation of helium bubble at high dpa region. Furthermore, in the helium irradiated materials, recovery of hardening could not be observed even for annealed materials at 1173 K for 1 hr after irradiation. From such results, hardening promotion work due to helium and extreme thermal stability of the formed defects were elucidated. (B.K.)

  18. Disorientations and work-hardening behaviour during severe plastic deformation

    DEFF Research Database (Denmark)

    Pantleon, Wolfgang

    2012-01-01

    Orientation differences develop during plastic deformation even in grains of originally uniform orientation. The evolution of these disorientations is modelled by dislocation dynamics taking into account different storage mechanisms. The predicted average disorientation angles across different ty...... pressure torsion, but also rationalizes the work-hardening behaviour at large plastic strains as well as a saturation of the flow stress....

  19. Experiment research on grind-hardening of AISI5140 steel based on thermal copensation

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Xiang Ming; Ren, Ying Hui; Zheng, Bo; Zhou, Zhixiong [College of Mechanical and Vehicle Engineering, Hunan University, Changsha, Hunan (China); Deng, Zhao Hui [Key Laboratory for High Efficiency and Precision Machining of Difficult-to-Cut Material of Hunan Province, Hunan (China)

    2016-08-15

    The grind-hardening process utilizes the heat generated to induce martensitic phase transformation. However, the maximum achievable harden layer depth is limited due to high grinding forces, and the tensile residual stress appears on the ground surface in the grind-hardening process. This paper proposes a new grind-hardening technology using thermal compensation. The workpiece of AISI5140 steel is preheated by electric resistance heating, and ground under the condition of the workpiece temperature 25°C, 120°C, 180°C and 240°C. The grinding force, harden layer depth and surface quality including residual stress on ground surface, surface roughness and micro-hardness are investigated. The experimental results show that a deep harden layer with a fine grain martensite can be obtained with the thermal compensation. The ground workpiece surface produces a certain compressive residual stress, and the residual compressive stress value increases with preheating temperature. As the preheating temperature increases, grinding force slightly decreases, while there is slightly increment of surface roughness. Compared with the conventional grind-hardening process, both the harden layer depth and residual stress distribution are significantly improved.

  20. Influence of Plastic Deformation on Low Temperature Surface Hardening of Austenitic and Precipitation Hardening Stainless Steels by Gaseous Nitriding

    DEFF Research Database (Denmark)

    Bottoli, Federico; Winther, Grethe; Christiansen, Thomas Lundin

    2015-01-01

    This article addresses an investigation of the influence of plastic deformation on low temperature surface hardening by gaseous nitriding of three commercial austenitic stainless steels: AISI 304, EN 1.4369 and Sandvik Nanoflex® with various degrees of austenite stability. The materials were...... case included X-ray diffraction analysis, reflected light microscopy and microhardness. The results demonstrate that a case of expanded austenite develops and that, in particular, strain-induced martensite has a large influence on the nitrided zone....

  1. Registration of cytoplasmic male-sterile oilseed sunflower genetic stocks CMS GIG2 and CMS GIG2-RV, and fertility restoration lines RF GIG2-MAX 1631 and RF GIG2-MAX 1631-RV

    Science.gov (United States)

    Two cytoplasmic male-sterile (CMS) oilseed sunflower (Helianthus annuus L.) genetic stocks, CMS GIG2 (Reg. No. xxx, PI xxxx), and CMS GIG2-RV (Reg. No. xxx, PI xxxx), and corresponding fertility restoration lines RF GIG2-MAX 1631 (Reg. No. xxx, PI xxxx) and RF GIG2-MAX 1631-RV (Reg. No. xxx, PI xxx...

  2. Cloning, overexpression, purification and preliminary X-ray analysis of a feast/famine regulatory protein (Rv2779c) from Mycobacterium tuberculosis H37Rv.

    Science.gov (United States)

    Dey, Abhishek; Ramachandran, Ravishankar

    2014-01-01

    Rv2779c from Mycobacterium tuberculosis is a feast/famine regulatory protein. This class of proteins are also known as the leucine-responsive regulatory protein/asparagine synthase C family (Lrp/AsnC) of transcriptional regulators and are known to be involved in various metabolic processes in bacteria and fungi. They contain a RAM (regulator of amino-acid metabolism) domain that is rarely found in humans and acts as the oligomerization domain. Since the oligomeric status is often linked to the particular functional role in these proteins, binding of ligands to the domain can elicit specific functional responses. Full-length Rv2779c corresponding to a molecular mass of 19.8 kDa and 179 residues was cloned and purified to homogeneity following transformation into Escherichia coli C41 (DE3) cells. Crystals were grown by vapour diffusion using the hanging-drop method. Diffraction data extending to 2.8 Å resolution were collected from a single crystal that belonged to space group P2(1)2(1)2, with unit-cell parameters a = 99.6, b = 146.0, c = 49.9 Å. Matthews coefficient (VM) calculations suggest that four molecules are present in the asymmetric unit, corresponding to a solvent content of ∼46%. Molecular-replacement calculations using the crystal structure of a homologue, Rv3291c, as the search model gave an unambiguous solution corresponding to four subunits in the asymmetric unit.

  3. Comparative Study of Hardening Mechanisms During Aging of a 304 Stainless Steel Containing α'-Martensite

    Science.gov (United States)

    Jeong, S. W.; Kang, U. G.; Choi, J. Y.; Nam, W. J.

    2012-09-01

    Strain aging and hardening behaviors of a 304 stainless steel containing deformation-induced martensite were investigated by examining mechanical properties and microstructural evolution for different aging temperature and time. Introduced age hardening mechanisms of a cold rolled 304 stainless steel were the additional formation of α'-martensite, hardening of α'-martensite, and hardening of deformed austenite. The increased amount of α'-martensite at an aging temperature of 450 °C confirmed the additional formation of α'-martensite as a hardening mechanism in a cold rolled 304 stainless steel. Additionally, the increased hardness in both α'-martensite and austenite phases with aging temperature proved that hardening of both α'-martensite and austenite phases would be effective as hardening mechanisms in cold rolled and aged 304 stainless steels. The results suggested that among hardening mechanisms, hardening of an α'-martensite phase, including the diffusion of interstitial solute carbon atoms to dislocations and the precipitation of fine carbide particles would become a major hardening mechanism during aging of cold rolled 304 stainless steels.

  4. Analysis of the work-hardening process in spheroidized steels

    International Nuclear Information System (INIS)

    Pacheco, J.L.

    1981-07-01

    An elementary model for the work-hardening process in duplex-structures steels (ferrite - spheroidite) is proposed and tested on low, medium and high carbon content, which seems to give good results concerning the influence of the volume fraction and particle size of the second phase on the work-hardening behaviour. (Author) [pt

  5. Design and characterization of cellulose nanocrystal-enhanced epoxy hardeners

    Science.gov (United States)

    Shane X. Peng; Robert J. Moon; Jeffrey P. Youngblood

    2014-01-01

    Cellulose nanocrystals (CNCs) are renewable, sustainable, and abundant nanomaterial widely used as reinforcing fillers in the field of polymer nanocomposites. In this study, two-part epoxy systems with CNC-enhanced hardeners were fabricated. Three types of hardeners, Jeffamine D400 (JD400), diethylenetriamine (DETA), and (±)-trans-1,2- diaminocyclohexane (DACH), were...

  6. Physical and Thermodynamical Properties of Water Phases in Hardening Portland Cement Systems

    DEFF Research Database (Denmark)

    Hansen, T. Bæk

    The present study is devoted to the description of water phases in hardening portland cement paste systems containing a significant amount of micro-filler and having a low to moderate water/powder ratio. Emphasis has been placed on the early stages of the hardening process.......The present study is devoted to the description of water phases in hardening portland cement paste systems containing a significant amount of micro-filler and having a low to moderate water/powder ratio. Emphasis has been placed on the early stages of the hardening process....

  7. Modification of Grange-Kiefer Approach for Determination of Hardenability in Eutectoid Steel

    Science.gov (United States)

    Sushanthi, Neethi; Maity, Joydeep

    2014-12-01

    In this research work, an independent mathematical modeling approach has been adopted for determination of the hardenability of steels. In this model, at first, cooling curves were generated by solving transient heat transfer equation through discretization with pure explicit finite difference scheme coupled with MATLAB-based programming considering variable thermo-physical properties of 1080 steel. Thereafter, a new fundamental approach is proposed for obtaining CCT noses as a function of volume fraction transformed through modification of Grange-Kiefer approach. The cooling curves were solved against 50 pct transformation nose of CCT diagram in order to predict hardening behavior of 1080 steel in terms of hardenability parameters (Grossmann critical diameter, D C; and ideal critical diameter, D I) and the variation of the unhardened core diameter ( D u) to diameter of steel bar ( D) ratio with diameter of the steel bar ( D). The experiments were also performed to ascertain actual D C value of 1080 steel for still water quenching. The D C value obtained by the developed model was found to match the experimental D C value with only 3 pct deviation. Therefore, the model developed in the present work can be used for direct determination of D I, D C and D u without resorting to any rigorous experimentation.

  8. The microstructural origin of strain hardening in two-dimensional open-cell metal foams

    NARCIS (Netherlands)

    Mangipudi, K. R.; van Buuren, S. W.; Onck, P. R.

    2010-01-01

    This paper aims at elucidating the microstructural origin of strain hardening in open-cell metal foams. We have developed a multiscale model that allows to study the development of plasticity at two length scales: (i) the development of plastic zones inside individual struts (microscopic scale) and

  9. Radiation hardening revisited: Role of intracascade clustering

    DEFF Research Database (Denmark)

    Singh, B.N.; Foreman, A.J.E.; Trinkaus, H.

    1997-01-01

    be explained in terms of conventional dispersed-barrier hardening because (a) the grown-in dislocations are not free, and (b) irradiation-induced defect clusters are not rigid indestructible Orowan obstacles. A new model called 'cascade-induced source hardening' is presented where glissile loops produced...... directly in cascades are envisaged to decorate the grown-in dislocations so that they cannot act as dislocation sources. The upper yield stress is related to the breakaway stress which is necessary to pull the dislocation away from the clusters/loops decorating it. The magnitude of the breakaway stress has...

  10. MOULDING MIXTURES HARDENING PROCESS BASED ON LIGNIN-BASE SULPHONATE BINDER

    Directory of Open Access Journals (Sweden)

    V. N. Ektova

    2004-01-01

    Full Text Available Hardening of agglutinant sands on lignosulphonate binding agent is the result of two processes: oxidation-reduction in the system lignosulphonate acids — persulfuric natrium in the early stages of hardening and hydration of cement in the latter stages.

  11. Radiation-hardened optoelectronic components: detectors

    International Nuclear Information System (INIS)

    Wiczer, J.J.

    1986-01-01

    In this talk, we will survey recent research in the area of radiation hardened optical detectors. We have studied conventional silicon photodiode structures, special radiation hardened silicon photodiodes, and special double heterojunction AlGaAs/GaAs photodiodes in neutron, gamma, pulsed x-ray and charged particle environments. We will present results of our work and summarize other research in this area. Our studies have shown that detectors can be made to function acceptably after exposures to neutron fluences of 10 15 n/cm 2 , total dose gamma exposures of 10 8 rad (Si), and flash x-ray environments of 10 8 rad/sec (Si). We will describe detector structures that can operate through these conditions, pre-rad and post-rad operational characteristics, and experimental conditions that produced these results. 23 refs., 10 figs., 1 tab

  12. Avastatud maa-alune järv võib lõpetada Darfuri kodusõja / Karin Volmer

    Index Scriptorium Estoniae

    Volmer, Karin

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke, 23. juuli 2007, lk. 6. Teadlaste hinnangul võib Darfuri konflikti lõpetada Darfuris avastatud maa-alune järv, sest kodusõda araablastest karjakasvatajate ja põlluharijatest põliselanike vahel võib tingitud olla veepuudusest. Kaart: Darfuri maa-alune järv. Lisa: Darfuri konflikt

  13. Radiation hardening of metals irradiated by heavy ions

    International Nuclear Information System (INIS)

    Didyk, A.Yu.; Skuratov, V.A.; Mikhajlova, N.Yu.; Regel', V.R.

    1988-01-01

    The damage dose dependence in the 10 -4 -10 -2 dpa region of radiation hardening of Al, V, Ni, Cu irradiated by xenon ions with 124 MeV energy is investigated using the microhardness technique and transmission electron microscope. It is shown that the pure metals radiation hardening is stimulated for defects clusters with the typical size less than 5 nm, as in the case of neutron and the light charge ion irradiation

  14. The Norwood procedure: in favor of the RV-PA conduit.

    Science.gov (United States)

    Barron, David J

    2013-01-01

    Evolution of the Norwood procedure has culminated in there currently being three treatment strategies available for initial management: the 'classical' Norwood (utilizing a Blalock-Taussig shunt), the Norwood with right-ventricle to pulmonary artery (RV-PA) conduit, and the 'hybrid' Norwood procedure utilizing bilateral pulmonary artery banding and ductal stenting. Each variant has its potential advantages and disadvantages, and this paper looks to examine the evidence in favor of each strategy, with emphasis on the supportive data for the RV-PA conduit. The 'classical' procedure has the benefit of the greatest accumulated surgical experience and avoids any incision into the ventricle. However, the diastolic run-off of the Blalock-Taussig shunt can cause hemodynamic instability and unpredictable coronary steal phenomenon. The RV-PA conduit has the advantage of maintaining diastolic pressure with a more stable postoperative course, but at the cost of a ventriculotomy that may have detrimental long-term sequelae. The 'hybrid' procedure has the advantage of avoiding cardiopulmonary bypass, but does not always secure coronary blood flow and has a high inter-stage morbidity and reintervention rate. The evidence shows that each technique may have its place in future management, and that treatment algorithms could emerge that direct the choice of procedure for specific patient groups. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. Radial velocity variations of photometrically quiet, chromospherically inactive Kepler stars: A link between RV jitter and photometric flicker

    Energy Technology Data Exchange (ETDEWEB)

    Bastien, Fabienne A.; Stassun, Keivan G.; Pepper, Joshua [Physics and Astronomy Department, Vanderbilt University, 1807 Station B, Nashville, TN 37235 (United States); Wright, Jason T. [Center for Exoplanets and Habitable Worlds, 525 Davey Laboratory, The Pennsylvania State University, University Park, PA 16803 (United States); Aigrain, Suzanne [Sub-department of Astrophysics, Department of Physics, University of Oxford, Oxford OX1 3RH (United Kingdom); Basri, Gibor [Astronomy Department, University of California, Berkeley, CA 94720 (United States); Johnson, John A. [Department of Astrophysics, California Institute of Technology, MC 249-17, Pasadena, CA 91125 (United States); Howard, Andrew W. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Walkowicz, Lucianne M. [Department of Astrophysical Sciences, Princeton University, 4 Ivy Lane, Princeton, NJ 08544 (United States)

    2014-02-01

    We compare stellar photometric variability, as measured from Kepler light curves by Basri et al., with measurements of radial velocity (RV) rms variations of all California Planet Search overlap stars. We newly derive rotation periods from the Kepler light curves for all of the stars in our study sample. The RV variations reported herein range from less than 4 to 135 m s{sup –1}, yet the stars all have amplitudes of photometric variability less than 3 mmag, reflecting the preference of the RV program for chromospherically 'quiet' stars. Despite the small size of our sample, we find with high statistical significance that the RV rms manifests strongly in the Fourier power spectrum of the light curve: stars that are noisier in RV have a greater number of frequency components in the light curve. We also find that spot models of the observed light curves systematically underpredict the observed RV variations by factors of ∼2-1000, likely because the low-level photometric variations in our sample are driven by processes not included in simple spot models. The stars best fit by these models tend to have simpler light curves, dominated by a single relatively high-amplitude component of variability. Finally, we demonstrate that the RV rms behavior of our sample can be explained in the context of the photometric variability evolutionary diagram introduced by Bastien et al. We use this diagram to derive the surface gravities of the stars in our sample, revealing many of them to have moved off the main sequence. More generally, we find that the stars with the largest RV rms are those that have evolved onto the 'flicker floor' sequence in that diagram, characterized by relatively low amplitude but highly complex photometric variations which grow as the stars evolve to become subgiants.

  16. Mutation of Rv2887, a marR-like gene, confers Mycobacterium tuberculosis resistance to an imidazopyridine-based agent.

    Science.gov (United States)

    Winglee, Kathryn; Lun, Shichun; Pieroni, Marco; Kozikowski, Alan; Bishai, William

    2015-11-01

    Drug resistance is a major problem in Mycobacterium tuberculosis control, and it is critical to identify novel drug targets and new antimycobacterial compounds. We have previously identified an imidazo[1,2-a]pyridine-4-carbonitrile-based agent, MP-III-71, with strong activity against M. tuberculosis. In this study, we evaluated mechanisms of resistance to MP-III-71. We derived three independent M. tuberculosis mutants resistant to MP-III-71 and conducted whole-genome sequencing of these mutants. Loss-of-function mutations in Rv2887 were common to all three MP-III-71-resistant mutants, and we confirmed the role of Rv2887 as a gene required for MP-III-71 susceptibility using complementation. The Rv2887 protein was previously unannotated, but domain and homology analyses suggested it to be a transcriptional regulator in the MarR (multiple antibiotic resistance repressor) family, a group of proteins first identified in Escherichia coli to negatively regulate efflux pumps and other mechanisms of multidrug resistance. We found that two efflux pump inhibitors, verapamil and chlorpromazine, potentiate the action of MP-III-71 and that mutation of Rv2887 abrogates their activity. We also used transcriptome sequencing (RNA-seq) to identify genes which are differentially expressed in the presence and absence of a functional Rv2887 protein. We found that genes involved in benzoquinone and menaquinone biosynthesis were repressed by functional Rv2887. Thus, inactivating mutations of Rv2887, encoding a putative MarR-like transcriptional regulator, confer resistance to MP-III-71, an effective antimycobacterial compound that shows no cross-resistance to existing antituberculosis drugs. The mechanism of resistance of M. tuberculosis Rv2887 mutants may involve efflux pump upregulation and also drug methylation. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  17. Laser quench hardening of steel: Effects of superimposed elastic pre-stress on the hardness and residual stress distribution

    Science.gov (United States)

    Meserve, Justin

    Cold drawn AISI 4140 beams were LASER surface hardened with a 2 kW CO2 LASER. Specimens were treated in the free state and while restrained in a bending fixture inducing surface tensile stresses of 94 and 230 MPa. Knoop hardness indentation was used to evaluate the through thickness hardness distribution, and a layer removal methodology was used to evaluate the residual stress distribution. Results showed the maximum surface hardness attained was not affected by pre-stress during hardening, and ranged from 513 to 676 kg/mm2. The depth of effective hardening varied at different magnitudes of pre-stress, but did not vary proportionately to the pre-stress. The surface residual stress, coinciding with the maximum compressive residual stress, increased as pre-stress was increased, from 1040 MPa for the nominally treated specimens to 1270 MPa for specimens pre-stressed to 230 MPa. The maximum tensile residual stress observed in the specimens decreased from 1060 MPa in the nominally treated specimens to 760 MPa for specimens pre-stressed to 230 MPa. Similarly, thickness of the compressive residual stress region increased and the depth at which maximum tensile residual stress occurred increased as the pre-stress during treatment was increased Overall, application of tensile elastic pre-stress during LASER hardening is beneficial to the development of compressive residual stress in AISI 4140, with minimal impact to the hardness attained from the treatment. The newly developed approach for LASER hardening may support efforts to increase both the wear and fatigue resistance of parts made from hardenable steels.

  18. Increase of resistance to cracking on stress relieving of hardened steel

    International Nuclear Information System (INIS)

    Velichko, V.V.; Zabil'skij, V.V.; Mikheev, G.M.

    1995-01-01

    Regularities of increase of resistance to cracking during stress relieving of hardened low-alloyed steels were studied, using complex of methods. Effect of carbon, stress concentrator radius, duration and temperature of stress relieving was studies in particular. Results of investigating kinetics of change of physicomechanical properties, hydrogen desorption from hardened specimens showed, that increase of resistance to cracking was caused by desorption from grain boundaries of diffusion-mobile hydrogen, formed during hardening. 18 refs., 8 figs

  19. Some aspects of plasticity in hardened face-centred cubic metals

    International Nuclear Information System (INIS)

    Jackson, P.J.; Nathanson, P.D.K.

    1978-01-01

    The plasticity of crystals of f.c.c. metals hardened by solute atoms, neutron irradiation, quenching and by dislocation distributions not characteristic of the active mode of testing is reviewed, with emphasis being placed on the simiularity of slip after various hardening treatments. Normal work hardening is not treated. The reasons for this exclusion are discussed. It is concluded that correlated slip is a normal aspect of deformation, and that diffuse uncorrelated slip occurs only when secondary dislocation multiplication is promoted, e.g. by obstacles introduced by prior slip, or by the presence of hard impenetrable obstacles of another material or phase [af

  20. Work hardening behavior study of structural alloys for cryogenic applications

    International Nuclear Information System (INIS)

    Chu, D.; Morris, J.W. Jr.

    1992-01-01

    Previous investigation on aluminum-lithium alloys have indicated different dependencies of the work hardening behavior on temperature. This variation in temperature dependence is attributed to differences in microstructure rather than composition. An understanding of the microstructural effect on the observed thermal dependency is important as it may allow the tailoring of deformation properties through mechanical processing. Work hardening analyses on other aluminum alloys and a number of structural steels have been performed to better elucidate the role played by microstructure in determining the work hardening behavior. In the paper correlations between the differences in mechanical behavior and the various microstructures observed are presented

  1. General analytical shakedown solution for structures with kinematic hardening materials

    Science.gov (United States)

    Guo, Baofeng; Zou, Zongyuan; Jin, Miao

    2016-09-01

    The effect of kinematic hardening behavior on the shakedown behaviors of structure has been investigated by performing shakedown analysis for some specific problems. The results obtained only show that the shakedown limit loads of structures with kinematic hardening model are larger than or equal to those with perfectly plastic model of the same initial yield stress. To further investigate the rules governing the different shakedown behaviors of kinematic hardening structures, the extended shakedown theorem for limited kinematic hardening is applied, the shakedown condition is then proposed, and a general analytical solution for the structural shakedown limit load is thus derived. The analytical shakedown limit loads for fully reversed cyclic loading and non-fully reversed cyclic loading are then given based on the general solution. The resulting analytical solution is applied to some specific problems: a hollow specimen subjected to tension and torsion, a flanged pipe subjected to pressure and axial force and a square plate with small central hole subjected to biaxial tension. The results obtained are compared with those in literatures, they are consistent with each other. Based on the resulting general analytical solution, rules governing the general effects of kinematic hardening behavior on the shakedown behavior of structure are clearly.

  2. Effects of solute elements on irradiation hardening and microstructural evolution in low alloy steels

    Energy Technology Data Exchange (ETDEWEB)

    Fujii, Katsuhiko, E-mail: fujiik@inss.co.jp [Institute of Nuclear Safety System Inc., 64 Sata, Mihama 919-1205 (Japan); Ohkubo, Tadakatsu, E-mail: OHKUBO.Tadakatsu@nims.go.jp [National Institute for Materials Science, 1-2-1 Sengen, Tsukuba 305-0047 (Japan); Fukuya, Koji, E-mail: fukuya@inss.co.jp [Institute of Nuclear Safety System Inc., 64 Sata, Mihama 919-1205 (Japan)

    2011-10-01

    The effects of the elements Mn, Ni, Si and Cu on irradiation hardening and microstructural evolution in low alloy steels were investigated in ion irradiation experiments using five kinds of alloys prepared by removing Mn, Ni and Si from, and adding 0.05 wt.%Cu to, the base alloy (Fe-1.5Mn-0.5Ni-0.25Si). The alloy without Mn showed less hardening and the alloys without Ni or Si showed more hardening. The addition of Cu had hardly any influence on hardening. These facts indicated that Mn enhanced hardening and that Ni and Si had some synergetic effects. The formation of solute clusters was not confirmed by atom probe (AP) analysis, whereas small dislocation loops were identified by TEM observation. The difference in hardening between the alloys with and without Mn was qualitatively consistent with loop formation. However, microstructural components that were not detected by the AP and TEM were assumed to explain the hardening level quantitatively.

  3. OCCUPATIONAL ASTHMA CAUSED BY A HARDENER CONTAINING AN ALIPHATIC AND A CYCLOALIPHATIC DIAMINE

    NARCIS (Netherlands)

    ALEVA, RM; AALBERS, R; KOETER, GH; DEMONCHY, JGR

    An otherwise healthy 44-yr-old man experienced a serious attack of bronchial obstruction after working with resins and hardeners, releasing fumes of a mixture of an aliphatic and a cycloaliphatic diamine hardener. Eight hours after deliberate challenge with the hardener a large increase of airway

  4. Optimized radiation-hardened erbium doped fiber amplifiers for long space missions

    Science.gov (United States)

    Ladaci, A.; Girard, S.; Mescia, L.; Robin, T.; Laurent, A.; Cadier, B.; Boutillier, M.; Ouerdane, Y.; Boukenter, A.

    2017-04-01

    In this work, we developed and exploited simulation tools to optimize the performances of rare earth doped fiber amplifiers (REDFAs) for space missions. To describe these systems, a state-of-the-art model based on the rate equations and the particle swarm optimization technique is developed in which we also consider the main radiation effect on REDFA: the radiation induced attenuation (RIA). After the validation of this tool set by confrontation between theoretical and experimental results, we investigate how the deleterious radiation effects on the amplifier performance can be mitigated following adequate strategies to conceive the REDFA architecture. The tool set was validated by comparing the calculated Erbium-doped fiber amplifier (EDFA) gain degradation under X-rays at ˜300 krad(SiO2) with the corresponding experimental results. Two versions of the same fibers were used in this work, a standard optical fiber and a radiation hardened fiber, obtained by loading the previous fiber with hydrogen gas. Based on these fibers, standard and radiation hardened EDFAs were manufactured and tested in different operating configurations, and the obtained data were compared with simulation data done considering the same EDFA structure and fiber properties. This comparison reveals a good agreement between simulated gain and experimental data (vulnerability in terms of gain. The presented approach is a complementary and effective tool for hardening by device techniques and opens new perspectives for the applications of REDFAs and lasers in harsh environments.

  5. Effect of hardening methods of moulding sands with water glass on structure of bonding bridges

    Directory of Open Access Journals (Sweden)

    M. Stachowicz

    2010-07-01

    Full Text Available Research on influence of hardening methods on structure of bonding bridges in moulding sands with sodium water glass is presented.Moulding sands with addition of 2.5 % of binder with molar module 2.0 were hardened with CO2 and dried in traditional way or hardenedwith microwaves. It was proved that the hardening method affects structure of bonding bridges, correlating with properties of the hardened moulding sands. It was found that strength of the moulding sands hardened with microwaves for 4 min is very close to that measured after traditional drying at 110 °C for 120 min. So, application of microwave hardening ensures significant shortening of the process time to the value comparable with CO2 hardening but guaranteeing over 10-fold increase of mechanical properties. Analysis of SEM images of hardened moulding sands permitted explaining differences in quality parameters of moulding sands by connecting them with structure of the created bonding bridges.

  6. Generation Mechanism of Work Hardened Surface Layer in Metal Cutting

    Science.gov (United States)

    Hikiji, Rikio; Kondo, Eiji; Kawagoishi, Norio; Arai, Minoru

    Finish machining used to be carried out in grinding, but it is being replaced by cutting with very small undeformed chip thickness. In ultra precision process, the effects of the cutting conditions and the complicated factors on the machined surface integrity are the serious problems. In this research, work hardened surface layer was dealt with as an evaluation of the machined surface integrity and the effect of the mechanical factors on work hardening was investigated experimentally in orthogonal cutting. As a result, it was found that work hardened surface layer was affected not only by the shear angle varied under the cutting conditions and the thrust force of cutting resistance, but also by the thrust force acting point, the coefficient of the thrust force and the compressive stress equivalent to the bulk hardness. Furthermore, these mechanical factors acting on the depth of the work hardened surface layer were investigated with the calculation model.

  7. Temperature Effects on the Tensile Properties of Precipitation-Hardened Al-Mg-Cu-Si Alloys

    Directory of Open Access Journals (Sweden)

    J.B. Ferguson

    2016-02-01

    Full Text Available Because the mechanical performance of precipitation-hardened alloys can be significantly altered with temperature changes, understanding and predicting the effects of temperatures on various mechanical properties for these alloys are important. In the present work, an analytical model has been developed to predict the elastic modulus, the yield stress, the failure stress, and the failure strain taking into consideration the effect of temperatures for precipitation-hardenable Al-Mg-Cu-Si Alloys (Al-A319 alloys. In addition, other important mechanical properties of Al-A319 alloys including the strain hardening exponent, the strength coefficient, and the ductility parameter can be estimated using the current model. It is demonstrated that the prediction results based on the proposed model are in good agreement with those obtained experimentally in Al-A319 alloys in the as-cast condition and after W and T7 heat treatments.

  8. Unit rupture work as a criterion for quantitative estimation of hardenability in steel

    International Nuclear Information System (INIS)

    Kramarov, M.A.; Orlov, E.D.; Rybakov, A.B.

    1980-01-01

    Shown is possible utilization of high sensitivity of resistance to fracture of structural steel to the hardenability degree in the course of hardening to find the quantitative estimation of the latter one. Proposed is a criterion kappa, the ratio of the unit rupture work in the case of incomplete hardenability (asub(Tsub(ih))) under investigation, and the analoguc value obtained in the case of complete hardenability Asub(Tsub(Ch)) at the testing temperature corresponding to the critical temperature Tsub(100(M). Confirmed is high criterion sensitivity of the hardened steel structure on the basis of experimental investigation of the 40Kh, 38KhNM and 38KhNMFA steels after isothermal hold-up at different temperatures, corresponding to production of various products of austenite decomposition

  9. Determination of the strain hardening rate of metals and alloys by X ray diffraction

    International Nuclear Information System (INIS)

    Cadalbert, Robert

    1977-01-01

    This report for engineering graduation is based on the study of X ray diffraction line profile which varies with the plastic strain rate of the metal. After some generalities of strain hardening (consequence of a plastic deformation on the structure of a polycrystalline metal, means to study a strain hardened structure, use of X ray diffraction to analyse the strain hardened crystalline structure), the author reports the strain hardening rate measurement by using X ray diffraction. Several aspects are addressed: principles, experimental technique, apparatus, automation and programming of the measurement cycle, method sensitivity and precision. In the next part, the author reports applications: measurement of the strain hardening rate in different materials (tubes with hexagonal profile, cylindrical tubes in austenitic steel), and study of the evolution of strain hardening with temperature [fr

  10. Radiation hardening of optical fibers and fiber sensors for space applications: recent advances

    Science.gov (United States)

    Girard, S.; Ouerdane, Y.; Pinsard, E.; Laurent, A.; Ladaci, A.; Robin, T.; Cadier, B.; Mescia, L.; Boukenter, A.

    2017-11-01

    In these ICSO proceedings, we review recent advances from our group concerning the radiation hardening of optical fiber and fiber-based sensors for space applications and compare their benefits to state-of-the-art results. We focus on the various approaches we developed to enhance the radiation tolerance of two classes of optical fibers doped with rare-earths: the erbium (Er)-doped ones and the ytterbium/erbium (Er/Yb)-doped ones. As a first approach, we work at the component level, optimizing the fiber structure and composition to reduce their intrinsically high radiation sensitivities. For the Erbium-doped fibers, this has been achieved using a new structure for the fiber that is called Hole-Assisted Carbon Coated (HACC) optical fibers whereas for the Er/Ybdoped optical fibers, their hardening was successfully achieved adding to the fiber, the Cerium element, that prevents the formation of the radiation-induced point defects responsible for the radiation induced attenuation in the infrared part of the spectrum. These fibers are used as part of more complex systems like amplifiers (Erbium-doped Fiber Amplifier, EDFA or Yb-EDFA) or source (Erbium-doped Fiber Source, EDFS or Yb- EDFS), we discuss the impact of using radiation-hardened fibers on the system radiation vulnerability and demonstrate the resistance of these systems to radiation constraints associated with today and future space missions. Finally, we will discuss another radiation hardening approach build in our group and based on a hardening-by-system strategy in which the amplifier is optimized during its elaboration for its future mission considering the radiation effects and not in-lab.

  11. Imunogenicidade da cepa avirulenta RV194-2 do vírus rábico em camundongos

    Directory of Open Access Journals (Sweden)

    Rugimar Marcovistz

    1996-12-01

    Full Text Available O vírus rábico RV194-2, uma variante avirulenta da cepa CVS (Challenge Vírus Standard, produz uma infecção inaparente quando inoculado intracerebralmente em camundongos adultos. Sugerindo que a resposta imunológica do hospedeiro permite a eliminação do vírus do sistema nervoso central. Por esta razão foram estudadas a indução de interferon e a resposta imune humoral em camundongos BALB/c inoculados com vírus RV194-2. Durante a infecção, estes camundongos apresentaram elevados níveis de interferon no plasma e no cérebro com altos títulos de anticorpos neutralizantes anti-rábicos. A 2-5A sintetase. um marcador da ação dos interferons,foi também analisada no cérebro destes animais. Sua atividade, aumentou, paralelamente, á produção de interferon, demonstrando que este interferon é bioquímicamente ativo. O vírus RV194-2 também induziu, 45 dias após sua inoculação, proteção aos animais quando desafiados com a cepa virulenta CVS. Estes resultados demonstram que a cepa RV194-2possui um alto nível imunogênico.RV194-2 rabies virus, an avirulent mutant of CVS strain, induces an inapparent infection limited to the central nervous system (CNS in adult mice inoculated intracerebrally. This fact suggest that immune response of the host is able to eliminate the virus in CNS. For this reason, we have studied the induction of interferon and the humoral immune responses in BALB/c mice after RV194-2 inoculation. These mice presented high levels of interferon in the plasma and in the brain, with elevated levels of neutralizing antirabies antibodies. The 2-5A synthetase, an enzyme marker of interferon action, was analyzed in the brain of inoculated animals. Its enhancement in parallel to the interferon production in the brain, showed biochemical evidence that this interferon is active. Forty five days after RV194-2 virus inoculation, mice were protected against a challenge with the CVS virulent strain. The results presented

  12. Segmentation-free empirical beam hardening correction for CT

    Energy Technology Data Exchange (ETDEWEB)

    Schüller, Sören; Sawall, Stefan [German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120 (Germany); Stannigel, Kai; Hülsbusch, Markus; Ulrici, Johannes; Hell, Erich [Sirona Dental Systems GmbH, Fabrikstraße 31, 64625 Bensheim (Germany); Kachelrieß, Marc, E-mail: marc.kachelriess@dkfz.de [German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg (Germany)

    2015-02-15

    Purpose: The polychromatic nature of the x-ray beams and their effects on the reconstructed image are often disregarded during standard image reconstruction. This leads to cupping and beam hardening artifacts inside the reconstructed volume. To correct for a general cupping, methods like water precorrection exist. They correct the hardening of the spectrum during the penetration of the measured object only for the major tissue class. In contrast, more complex artifacts like streaks between dense objects need other techniques of correction. If using only the information of one single energy scan, there are two types of corrections. The first one is a physical approach. Thereby, artifacts can be reproduced and corrected within the original reconstruction by using assumptions in a polychromatic forward projector. These assumptions could be the used spectrum, the detector response, the physical attenuation and scatter properties of the intersected materials. A second method is an empirical approach, which does not rely on much prior knowledge. This so-called empirical beam hardening correction (EBHC) and the previously mentioned physical-based technique are both relying on a segmentation of the present tissues inside the patient. The difficulty thereby is that beam hardening by itself, scatter, and other effects, which diminish the image quality also disturb the correct tissue classification and thereby reduce the accuracy of the two known classes of correction techniques. The herein proposed method works similar to the empirical beam hardening correction but does not require a tissue segmentation and therefore shows improvements on image data, which are highly degraded by noise and artifacts. Furthermore, the new algorithm is designed in a way that no additional calibration or parameter fitting is needed. Methods: To overcome the segmentation of tissues, the authors propose a histogram deformation of their primary reconstructed CT image. This step is essential for the

  13. Segmentation-free empirical beam hardening correction for CT.

    Science.gov (United States)

    Schüller, Sören; Sawall, Stefan; Stannigel, Kai; Hülsbusch, Markus; Ulrici, Johannes; Hell, Erich; Kachelrieß, Marc

    2015-02-01

    The polychromatic nature of the x-ray beams and their effects on the reconstructed image are often disregarded during standard image reconstruction. This leads to cupping and beam hardening artifacts inside the reconstructed volume. To correct for a general cupping, methods like water precorrection exist. They correct the hardening of the spectrum during the penetration of the measured object only for the major tissue class. In contrast, more complex artifacts like streaks between dense objects need other techniques of correction. If using only the information of one single energy scan, there are two types of corrections. The first one is a physical approach. Thereby, artifacts can be reproduced and corrected within the original reconstruction by using assumptions in a polychromatic forward projector. These assumptions could be the used spectrum, the detector response, the physical attenuation and scatter properties of the intersected materials. A second method is an empirical approach, which does not rely on much prior knowledge. This so-called empirical beam hardening correction (EBHC) and the previously mentioned physical-based technique are both relying on a segmentation of the present tissues inside the patient. The difficulty thereby is that beam hardening by itself, scatter, and other effects, which diminish the image quality also disturb the correct tissue classification and thereby reduce the accuracy of the two known classes of correction techniques. The herein proposed method works similar to the empirical beam hardening correction but does not require a tissue segmentation and therefore shows improvements on image data, which are highly degraded by noise and artifacts. Furthermore, the new algorithm is designed in a way that no additional calibration or parameter fitting is needed. To overcome the segmentation of tissues, the authors propose a histogram deformation of their primary reconstructed CT image. This step is essential for the proposed

  14. Anomalous precipitation hardening in Al-(1 wt%)Cu thin films

    NARCIS (Netherlands)

    Bergers, L. J. C.; De Hosson, J. Th. M.; Geers, M. G. D.; Hoefnagels, J. P. M.

    2018-01-01

    This paper concentrates on the precipitation hardening of Al-(1 wt%)Cu thin films. It is shown that in contrast to bulk, the well-known approach of precipitation hardening in confined systems like thin layers and thin films does not operate in the conventional way. This work analyses and discusses

  15. PERSPECTIVE TECHNOLOGIES OF THERMAL HARDENING OF LARGE-SIZE ARTICLES OF TWO-PHASE TITANIUM ALLOYS

    Directory of Open Access Journals (Sweden)

    V. N. Fedulov

    2005-01-01

    Full Text Available The article is dedicated to the development and industrial assimilation of the fundamentally new methods of thermal strengthening of large articles out of hardenable titanic alloys.

  16. Ion irradiation-induced swelling and hardening effect of Hastelloy N alloy

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, S.J. [Key Laboratory of Artificial Micro-and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072 (China); Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); Li, D.H.; Chen, H.C.; Lei, G.H.; Huang, H.F.; Zhang, W.; Wang, C.B. [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); Yan, L., E-mail: yanlong@sinap.ac.cn [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); Fu, D.J. [Key Laboratory of Artificial Micro-and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072 (China); Tang, M. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

    2017-06-15

    The volumetric swelling and hardening effect of irradiated Hastelloy N alloy were investigated in this paper. 7 MeV and 1 MeV Xe ions irradiations were performed at room temperature (RT) with irradiation dose ranging from 0.5 to 27 dpa. The volumetric swelling increases with increasing irradiation dose, and reaches up to 3.2% at 27 dpa. And the irradiation induced lattice expansion is also observed. The irradiation induced hardening initiates at low ion dose (≤1dpa) then saturates with higher ion dose. The irradiation induced volumetric swelling may be ascribed to excess atomic volume of defects. The irradiation induced hardening may be explained by the pinning effect where the defects can act as obstacles for the free movement of dislocation lines. And the evolution of the defects' size and number density could be responsible for the saturation of hardness. - Highlights: •Irradiation Swelling: The irradiation induced volumetric swelling increases with ion dose. •Irradiation Hardening: The irradiation hardening initiates below 1 dpa, then saturates with higher ion dose (1–10 dpa). •Irradiation Mechanism: The irradiation phenomena are ascribed to the microstructural evolution of the irradiation defects.

  17. The characterization of Vicker's microhardness indentations and pile-up profiles as a strain-hardening microprobe

    International Nuclear Information System (INIS)

    Santos, C. Jr.

    1998-04-01

    Microhardness measurements have long been used to examine strength properties and changes in strength properties in metals, for example, as induced by irradiation. Microhardness affords a relatively simple test that can be applied to very small volumes of material. Microhardness is nominally related to the flow stress of the material at a fixed level of plastic strain. Further, the geometry of the pile-up of material around the indentation is related to the strain-hardening behavior of a material; steeper pile-ups correspond to smaller strain-hardening rates. In this study the relationship between pile-up profiles and strain hardening is examined using both experimental and analytical methods. Vickers microhardness tests have been performed on a variety of metal alloys including low alloy, high Cr and austenitic stainless steels. The pile-up topology around the indentations has been quantified using confocal microscopy techniques. In addition, the indentation and pile-up geometry has been simulated using finite element method techniques. These results have been used to develop an improved quantification of the relationship between the pile-up geometry and the strain-hardening constitutive behavior of the test material

  18. Helium-induced hardening effect in polycrystalline tungsten

    Science.gov (United States)

    Kong, Fanhang; Qu, Miao; Yan, Sha; Zhang, Ailin; Peng, Shixiang; Xue, Jianming; Wang, Yugang

    2017-09-01

    In this paper, helium induced hardening effect of tungsten was investigated. 50 keV He2+ ions at fluences vary from 5 × 1015 cm-2 to 5 × 1017 cm-2 were implanted into polycrystalline tungsten at RT to create helium bubble-rich layers near the surface. The microstructure and mechanical properties of the irradiated specimens were studied by TEM and nano-indentor. Helium bubble rich layers are formed in near surface region, and the layers become thicker with the rise of fluences. Helium bubbles in the area of helium concentration peak are found to grow up, while the bubble density is almost unchanged. Obvious hardening effect is induced by helium implantation in tungsten. Micro hardness increases rapidly with the fluence firstly, and more slowly when the fluence is above 5 × 1016 cm-2. The hardening effect of tungsten can be attributed to helium bubbles, which is found to be in agreement with the Bacon-Orowan stress formula. The growing diameter is the major factor rather than helium bubbles density (voids distance) in the process of helium implantation at fluences below 5 × 1017 cm-2.

  19. Structure of Mycobacterium tuberculosis Rv2714, a representative of a duplicated gene family in Actinobacteria

    International Nuclear Information System (INIS)

    Graña, Martin; Bellinzoni, Marco; Miras, Isabelle; Fiez-Vandal, Cedric; Haouz, Ahmed; Shepard, William; Buschiazzo, Alejandro; Alzari, Pedro M.

    2009-01-01

    The crystal structure of Rv2714, a protein of unknown function from M. tuberculosis, has been determined at 2.6 Å resolution using single-wavelength anomalous diffraction methods. The gene Rv2714 from Mycobacterium tuberculosis, which codes for a hypothetical protein of unknown function, is a representative member of a gene family that is largely confined to the order Actinomycetales of Actinobacteria. Sequence analysis indicates the presence of two paralogous genes in most mycobacterial genomes and suggests that gene duplication was an ancient event in bacterial evolution. The crystal structure of Rv2714 has been determined at 2.6 Å resolution, revealing a trimer in which the topology of the protomer core is similar to that observed in a functionally diverse set of enzymes, including purine nucleoside phosphorylases, some carboxypeptidases, bacterial peptidyl-tRNA hydrolases and even the plastidic form of an intron splicing factor. However, some structural elements, such as a β-hairpin insertion involved in protein oligomerization and a C-terminal α-helical domain that serves as a lid to the putative substrate-binding (or ligand-binding) site, are only found in Rv2714 bacterial homologues and represent specific signatures of this protein family

  20. Structure of Mycobacterium tuberculosis Rv2714, a representative of a duplicated gene family in Actinobacteria

    Energy Technology Data Exchange (ETDEWEB)

    Graña, Martin; Bellinzoni, Marco [Institut Pasteur, Unité de Biochimie Structurale, URA CNRS 2185, 25 Rue du Dr Roux, 75724 Paris (France); Miras, Isabelle; Fiez-Vandal, Cedric; Haouz, Ahmed; Shepard, William [Institut Pasteur, Plate-forme de Cristallogenèse et Diffraction des Rayons X, 25 Rue du Dr Roux, 75724 Paris (France); Buschiazzo, Alejandro; Alzari, Pedro M., E-mail: alzari@pasteur.fr [Institut Pasteur, Unité de Biochimie Structurale, URA CNRS 2185, 25 Rue du Dr Roux, 75724 Paris (France)

    2009-10-01

    The crystal structure of Rv2714, a protein of unknown function from M. tuberculosis, has been determined at 2.6 Å resolution using single-wavelength anomalous diffraction methods. The gene Rv2714 from Mycobacterium tuberculosis, which codes for a hypothetical protein of unknown function, is a representative member of a gene family that is largely confined to the order Actinomycetales of Actinobacteria. Sequence analysis indicates the presence of two paralogous genes in most mycobacterial genomes and suggests that gene duplication was an ancient event in bacterial evolution. The crystal structure of Rv2714 has been determined at 2.6 Å resolution, revealing a trimer in which the topology of the protomer core is similar to that observed in a functionally diverse set of enzymes, including purine nucleoside phosphorylases, some carboxypeptidases, bacterial peptidyl-tRNA hydrolases and even the plastidic form of an intron splicing factor. However, some structural elements, such as a β-hairpin insertion involved in protein oligomerization and a C-terminal α-helical domain that serves as a lid to the putative substrate-binding (or ligand-binding) site, are only found in Rv2714 bacterial homologues and represent specific signatures of this protein family.

  1. Microstructural changes and strain hardening effects in abrasive contacts at different relative velocities and temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Rojacz, H., E-mail: rojacz@ac2t.at [AC2T research GmbH, Viktor-Kaplan-Straße 2C, 2700 Wiener Neustadt (Austria); Mozdzen, G. [Aerospace & Advanced Composites GmbH, Viktor-Kaplan-Straße 2F, 2700 Wiener Neustadt (Austria); Weigel, F.; Varga, M. [AC2T research GmbH, Viktor-Kaplan-Straße 2C, 2700 Wiener Neustadt (Austria)

    2016-08-15

    Strain hardening is commonly used to reach the full potential of materials and can be beneficial in tribological contacts. 2-body abrasive wear was simulated in a scratch test, aimed at strain hardening effects in various steels. Different working conditions were examined at various temperatures and velocities. Strain hardening effects and microstructural changes were analysed with high resolution scanning electron microscopy (HRSEM), electron backscatter diffraction (EBSD), micro hardness measurements and nanoindentation. Statistical analysing was performed quantifying the influence of different parameters on microstructures. Results show a crucial influence of temperature and velocity on the strain hardening in tribological contacts. Increased velocity leads to higher deformed microstructures and higher increased surface hardness at a lower depth of the deformed zones at all materials investigated. An optimised surface hardness can be achieved knowing the influence of velocity (strain rate) and temperature for a “tailor-made” surface hardening in tribological systems aimed at increased wear resistance. - Highlights: •Hardening mechanisms and their intensity in tribological contacts are dependent on relative velocity and temperature. •Beneficial surface hardened zones are formed at certain running-in conditions; the scientific background is presented here. •Ferritic-pearlitic steels strain hardens via grain size reduction and decreasing interlamellar distances in pearlite. •Austenitic steels show excellent surface hardening (120% hardness increase) by twinning and martensitic transformation. •Ferritic steels with hard phases harden in the ferrite phase as per Hall-Petch equation and degree of deformation.

  2. Microstructural changes and strain hardening effects in abrasive contacts at different relative velocities and temperatures

    International Nuclear Information System (INIS)

    Rojacz, H.; Mozdzen, G.; Weigel, F.; Varga, M.

    2016-01-01

    Strain hardening is commonly used to reach the full potential of materials and can be beneficial in tribological contacts. 2-body abrasive wear was simulated in a scratch test, aimed at strain hardening effects in various steels. Different working conditions were examined at various temperatures and velocities. Strain hardening effects and microstructural changes were analysed with high resolution scanning electron microscopy (HRSEM), electron backscatter diffraction (EBSD), micro hardness measurements and nanoindentation. Statistical analysing was performed quantifying the influence of different parameters on microstructures. Results show a crucial influence of temperature and velocity on the strain hardening in tribological contacts. Increased velocity leads to higher deformed microstructures and higher increased surface hardness at a lower depth of the deformed zones at all materials investigated. An optimised surface hardness can be achieved knowing the influence of velocity (strain rate) and temperature for a “tailor-made” surface hardening in tribological systems aimed at increased wear resistance. - Highlights: •Hardening mechanisms and their intensity in tribological contacts are dependent on relative velocity and temperature. •Beneficial surface hardened zones are formed at certain running-in conditions; the scientific background is presented here. •Ferritic-pearlitic steels strain hardens via grain size reduction and decreasing interlamellar distances in pearlite. •Austenitic steels show excellent surface hardening (120% hardness increase) by twinning and martensitic transformation. •Ferritic steels with hard phases harden in the ferrite phase as per Hall-Petch equation and degree of deformation.

  3. Karakterisasi Klon Rekombinan pGEMT-Rv1984c Sebagai Antigen untuk Imunodiagnostik Tuberkulosis Laten

    OpenAIRE

    Baharaeni, Wa Ode

    2017-01-01

    The research about "Characterization of Recombinant Clones pGEMT-Rv1984c as Antigen for Latent Tuberculosis Immunodiagnostic" has been done. Rv1984c gene is the gene that is owned by Mycobacterium tuberculosis, and encodes a protein formation CFP21 which serve as antigen candidate for latent tuberculosis immunodiagnostic through gene cloning. The result of transformation of gene cloning still has the possibility of failure of the process of transformation and ligation, so we need a character...

  4. Identification of novel adhesins of M. tuberculosis H37Rv using integrated approach of multiple computational algorithms and experimental analysis.

    Directory of Open Access Journals (Sweden)

    Sanjiv Kumar

    Full Text Available Pathogenic bacteria interacting with eukaryotic host express adhesins on their surface. These adhesins aid in bacterial attachment to the host cell receptors during colonization. A few adhesins such as Heparin binding hemagglutinin adhesin (HBHA, Apa, Malate Synthase of M. tuberculosis have been identified using specific experimental interaction models based on the biological knowledge of the pathogen. In the present work, we carried out computational screening for adhesins of M. tuberculosis. We used an integrated computational approach using SPAAN for predicting adhesins, PSORTb, SubLoc and LocTree for extracellular localization, and BLAST for verifying non-similarity to human proteins. These steps are among the first of reverse vaccinology. Multiple claims and attacks from different algorithms were processed through argumentative approach. Additional filtration criteria included selection for proteins with low molecular weights and absence of literature reports. We examined binding potential of the selected proteins using an image based ELISA. The protein Rv2599 (membrane protein binds to human fibronectin, laminin and collagen. Rv3717 (N-acetylmuramoyl-L-alanine amidase and Rv0309 (L,D-transpeptidase bind to fibronectin and laminin. We report Rv2599 (membrane protein, Rv0309 and Rv3717 as novel adhesins of M. tuberculosis H37Rv. Our results expand the number of known adhesins of M. tuberculosis and suggest their regulated expression in different stages.

  5. CASE-HARDENING OF STAINLESS STEEL

    DEFF Research Database (Denmark)

    2004-01-01

    The invention relates to case-hardening of a stainless steel article by means of gas including carbon and/or nitrogen, whereby carbon and/or nitrogen atoms diffuse through the surface into the article. The method includes activating the surface of the article, applying a top layer on the activated...

  6. Role of grain refinement in hardening of structural steels at preliminary thermomechanical treatment

    International Nuclear Information System (INIS)

    Bukhvalov, A.B.; Grigor'eva, E.V.; Davydova, L.S.; Degtyarev, M.V.; Levit, V.I.; Smirnova, N.A.; Smirnov, L.V.

    1981-01-01

    The hardening mechanism during preliminary thermomechanical treatment with deformation by cold rolling or hydroextrusion is studied on structural 37KhN3M1 and 38KhN3MFA steels. Specimens have been tested on static tension, impact strength and fracture toughness. It is shown that hydroextrusion application instead of rolling does not change the hardening effect of preliminary thermomechanical treatment (PTMT). It is established that the increase of preliminary deformation degree and the use of accelerated short term hardening heating provides a bett er grain refinement and the increase of PTMT hardening effect [ru

  7. Environmental hardening of a mobile-manipulator system for nuclear environments

    International Nuclear Information System (INIS)

    Jones, S.L.; Cable, T.; Tulenko, J.S.; Toshkov, S.; Sias, F.R. Jr.

    1993-01-01

    This research report discusses the radiation hardening of a commercially available mobile robot, the REMOTEC ANDROS. This hardening effort is culminating in the availability of a megarad hardened mobile platform to access areas in nuclear facilities with extremely high levels of radiation (0.1 to 1 Mrad). These radiation levels may be encountered both during routine repair and monitoring activities and accident situations. The project has completed a phase-I U.S. Department of Energy Small Business Innovative Research contract and is now in a phase-II effort with completion scheduled in early 1995. The research involves the evaluation of the material and electrical components of an ANDROS robot to determine the anticipated radiation hardness of the current production version and evaluation of the components that must be replaced or modified to harden the system to higher radiation levels. The work being reported is based on an evaluation of the complete list of all electronic, electrical, and mechanical parts used in the robot and includes initial experimental radiation evaluations performed at the University of Florida

  8. Analysis of the Effect of Cooling Intensity Under Volume-Surface Hardening on Formation of Hardened Structures in Steel 20GL

    Science.gov (United States)

    Evseev, D. G.; Savrukhin, A. V.; Neklyudov, A. N.

    2018-01-01

    Computer simulation of the kinetics of thermal processes and structural and phase transformations in the wall of a bogie side frame produced from steel 20GL is performed with allowance for the differences in the cooling intensity under volume-surface hardening. The simulation is based on the developed method employing the diagram of decomposition of austenite at different cooling rates. The data obtained are used to make conclusion on the effect of the cooling intensity on propagation of martensite structure over the wall section.

  9. Investigation of magnesium oxychloride cement at the initial hardening stage

    Directory of Open Access Journals (Sweden)

    Averina Galina

    2018-01-01

    Full Text Available The paper investigates the process of variation of magnesium oxychloride cement deformations at the initial hardening stage depending on the activity of magnesium oxide powder which is determined by the parameters of the source material burning. Investigation is focused on magnesium cements obtained from pure magnesium hydroxide. Source materials were burnt at various temperatures with the purpose to obtain magnesium oxide powder with different activity. Regular content of hydrated phases was determined in hardened magnesium cement prepared on the basis of binders with different activity. The study reveals the influence of magnesium oxide powder activity on the process of deformation occurrence in hardened magnesium cement and its tendency to crack formation.

  10. CMOS/SOS 4k Rams hardened to 100 Krads (s:)

    International Nuclear Information System (INIS)

    Napoli, L.S.; Heagerty, W.F.; Smeltzer, R.K.; Yeh, J.L.

    1982-01-01

    Two CMOS/SOS 4K memories were fabricated with a recently developed, hardened SOS process. Memory functionality after radiation doses well in excess of 100 Krads(Si) was demonstrated. The critical device processing steps were identified. The radiationinduced failure mode of the memories is understood in terms of the circuit organization and the radiation behavior of the individual transistors in the memories

  11. Hardening Effect Analysis by Modular Upper Bound and Finite Element Methods in Indentation of Aluminum, Steel, Titanium and Superalloys

    Directory of Open Access Journals (Sweden)

    Carolina Bermudo

    2017-05-01

    Full Text Available The application of incremental processes in the manufacturing industry is having a great development in recent years. The first stage of an Incremental Forming Process can be defined as an indentation. Because of this, the indentation process is starting to be widely studied, not only as a hardening test but also as a forming process. Thus, in this work, an analysis of the indentation process under the new Modular Upper Bound perspective has been performed. The modular implementation has several advantages, including the possibility of the introduction of different parameters to extend the study, such as the friction effect, the temperature or the hardening effect studied in this paper. The main objective of the present work is to analyze the three hardening models developed depending on the material characteristics. In order to support the validation of the hardening models, finite element analyses of diverse materials under an indentation are carried out. Results obtained from the Modular Upper Bound are in concordance with the results obtained from the numerical analyses. In addition, the numerical and analytical methods are in concordance with the results previously obtained in the experimental indentation of annealed aluminum A92030. Due to the introduction of the hardening factor, the new modular distribution is a suitable option for the analysis of indentation process.

  12. Numerical implementation of a transverse-isotropic inelastic, work-hardening constitutive model

    International Nuclear Information System (INIS)

    Baladi, G.Y.

    1977-01-01

    During the past few decades the dramatic growth of computer technology has been paralleled by an increasing degree of complexity in material constitutive modeling. This paper documents the numerical implementation of one of these models, specifically a transverse-isotropic, inelastic, work-hardening constitutive model which is developed elsewhere by the author. (Auth.)

  13. Efficient simulation of press hardening process through integrated structural and CFD analyses

    International Nuclear Information System (INIS)

    Palaniswamy, Hariharasudhan; Mondalek, Pamela; Wronski, Maciek; Roy, Subir

    2013-01-01

    Press hardened steel parts are being increasingly used in automotive structures for their higher strength to meet safety standards while reducing vehicle weight to improve fuel consumption. However, manufacturing of sheet metal parts by press hardening process to achieve desired properties is extremely challenging as it involves complex interaction of plastic deformation, metallurgical change, thermal distribution, and fluid flow. Numerical simulation is critical for successful design of the process and to understand the interaction among the numerous process parameters to control the press hardening process in order to consistently achieve desired part properties. Until now there has been no integrated commercial software solution that can efficiently model the complete process from forming of the blank, heat transfer between the blank and tool, microstructure evolution in the blank, heat loss from tool to the fluid that flows through water channels in the tools. In this study, a numerical solution based on Altair HyperWorks® product suite involving RADIOSS®, a non-linear finite element based structural analysis solver and AcuSolve®, an incompressible fluid flow solver based on Galerkin Least Square Finite Element Method have been utilized to develop an efficient solution for complete press hardening process design and analysis. RADIOSS is used to handle the plastic deformation, heat transfer between the blank and tool, and microstructure evolution in the blank during cooling. While AcuSolve is used to efficiently model heat loss from tool to the fluid that flows through water channels in the tools. The approach is demonstrated through some case studies

  14. Structure of hardened alloys of Sr-Rh system

    International Nuclear Information System (INIS)

    Dobromyslov, A.V.; Taluth, N.I.

    1997-01-01

    Methods of X-ray diffraction analysis, optical metallography, transmission electron microscopy and hardness measurement were applied to study the structure of hardened zirconium-rhodium system alloys with rhodium contents up to 4.5 at.%. It is shown that in hardening alloys with rhodium concentration lower 2.2 at.% the eutectoid decomposition takes place and bainite-like structure is formed. A metastable ω-phase is formed in alloys with rhodium concentration equal to 2.65 at.% and above. The formation of ω-phase suppresses the process of eutectoid decomposition

  15. Forkhead-associated (FHA) Domain Containing ABC Transporter Rv1747 Is Positively Regulated by Ser/Thr Phosphorylation in Mycobacterium tuberculosis*

    Science.gov (United States)

    Spivey, Vicky L.; Molle, Virginie; Whalan, Rachael H.; Rodgers, Angela; Leiba, Jade; Stach, Lasse; Walker, K. Barry; Smerdon, Stephen J.; Buxton, Roger S.

    2011-01-01

    One major signaling method employed by Mycobacterium tuberculosis, the causative agent of tuberculosis, is through reversible phosphorylation of proteins mediated by protein kinases and phosphatases. This study concerns one of these enzymes, the serine/threonine protein kinase PknF, that is encoded in an operon with Rv1747, an ABC transporter that is necessary for growth of M. tuberculosis in vivo and contains two forkhead-associated (FHA) domains. FHA domains are phosphopeptide recognition motifs that specifically recognize phosphothreonine-containing epitopes. Experiments to determine how PknF regulates the function of Rv1747 demonstrated that phosphorylation occurs on two specific threonine residues, Thr-150 and Thr-208. To determine the in vivo consequences of phosphorylation, infection experiments were performed in bone marrow-derived macrophages and in mice using threonine-to-alanine mutants of Rv1747 that prevent specific phosphorylation and revealed that phosphorylation positively modulates Rv1747 function in vivo. The role of the FHA domains in this regulation was further demonstrated by isothermal titration calorimetry, using peptides containing both phosphothreonine residues. FHA-1 domain mutation resulted in attenuation in macrophages highlighting the critical role of this domain in Rv1747 function. A mutant deleted for pknF did not, however, have a growth phenotype in an infection, suggesting that other kinases can fulfill its role when it is absent. This study provides the first information on the molecular mechanism(s) regulating Rv1747 through PknF-dependent phosphorylation but also indicates that phosphorylation activates Rv1747, which may have important consequences in regulating growth of M. tuberculosis. PMID:21622570

  16. Maillard-reaction-induced modification and aggregation of proteins and hardening of texture in protein bar model systems.

    Science.gov (United States)

    Zhou, Peng; Guo, Mufan; Liu, Dasong; Liu, Xiaoming; Labuza, Teodore P

    2013-03-01

    The hardening of high-protein bars causes problems in their acceptability to consumers. The objective of this study was to determine the progress of the Maillard reaction in model systems of high-protein nutritional bars containing reducing sugars, and to illustrate the influences of the Maillard reaction on the modification and aggregation of proteins and the hardening of bar matrices during storage. The progress of the Maillard reaction, glycation, and aggregation of proteins, and textural changes in bar matrices were investigated during storage at 25, 35, and 45 °C. The initial development of the Maillard reaction caused little changes in hardness; however, further storage resulted in dramatic modification of protein with formation of high-molecular-weight polymers, resulting in the hardening in texture. The replacement of reducing sugars with nonreducing ingredients such as sugar alcohols in the formula minimized the changes in texture. The hardening of high-protein bars causes problems in their acceptability to consumers. Maillard reaction is one of the mechanisms contributing to the hardening of bar matrix, particularly for the late stage of storage. The replacement of reducing sugars with nonreducing ingredients such as sugar alcohols in the formula will minimize the changes in texture. © 2013 Institute of Food Technologists®

  17. Effect of the hardener to epoxy monomer ratio on the water absorption behavior of the DGEBA/TETA epoxy system

    Directory of Open Access Journals (Sweden)

    Ayrton Alef Castanheira Pereira

    2016-02-01

    Full Text Available Abstract The water absorption behavior of the DGEBA/TETA epoxy system was evaluated as a function of the epoxy monomer to amine hardener ratio. Weight gain versus immersion time curves were obtained and the experimental points were fitted using Fickian and Non-Fickian diffusion models. The results obtained showed that for all epoxy monomer to hardener ratios analyzed water diffusion followed non-Fickian behavior. It was possible to correlate the water absorption behavior to the macromolecular structure developed when the epoxy/ hardener ratio was varied. All epoxy/hardener ratios present a two-phase macromolecular structure, composed of regions with high crosslink density and regions with lower crosslinking. Epoxy rich systems have a more open macromolecular structure with a lower fraction of the dense phase than the amine rich systems, which present a more compact two-phase structure.

  18. Technology of Anticorrosive Protection of Steel Constructions by Coatings Based on Rapid-Hardening Bitumen-Latex Emulsion

    Directory of Open Access Journals (Sweden)

    Nykyforchyn, H.M.

    2016-01-01

    Full Text Available The recipes of rapid-hardening bitumen-latex emulsions and coatings on its base are created, in-laboratory tests of their physical, chemical and anticorrosive properties are carried out. The technology of anticorrosive protection and the installation technical documentation for making of aqueous bitumen-latex emulsion is developed, installation is mounted and a pilot lot of rapid-hardening emulsion is produced. Experimental-industrial approbation of the technology of coating formation on pipes in oil and gas industry is carried out.

  19. Optimization of hardening/softening behavior of plane frame structures using nonlinear normal modes

    DEFF Research Database (Denmark)

    Dou, Suguang; Jensen, Jakob Søndergaard

    2016-01-01

    Devices that exploit essential nonlinear behavior such as hardening/softening and inter-modal coupling effects are increasingly used in engineering and fundamental studies. Based on nonlinear normal modes, we present a gradient-based structural optimization method for tailoring the hardening...... involving plane frame structures where the hardening/softening behavior is qualitatively and quantitatively tuned by simple changes in the geometry of the structures....

  20. Micromilling of hardened tool steel for mould making applications

    DEFF Research Database (Denmark)

    Bissacco, Giuliano; Hansen, Hans Nørgaard; De Chiffre, Leonardo

    2005-01-01

    geometries as those characterizing injection moulding moulds. The realization of the micromilling process in connection with hardened tool steel as workpiece material is particularly challenging. The low strength of the miniaturized end mills implies reduction and accurate control of the chip load which...... wear. This paper presents the micromilling process applied to the manufacturing of micro injection moulding moulds in hardened tool steel, presenting experimental evidence and possible solutions to the above-mentioned issues....

  1. Orowan strengthening and forest hardening superposition examined by dislocation dynamics simulations

    International Nuclear Information System (INIS)

    Queyreau, Sylvain; Monnet, Ghiath; Devincre, Benoit

    2010-01-01

    Rule of mixtures are an essential feature of the modeling of plastic deformation in complex materials in which more than one strain-hardening mechanism is involved. In this work, use is made of dislocation dynamics simulations to characterize the individual and the superposed contributions of two major mechanisms of crystal plasticity, i.e. Orowan strengthening and forest hardening. Based on a formal description of each hardening mechanism, evidence is presented to show that a quadratic rule of mixtures has the ability to predict quantitatively the flow stress of complex materials such as reactor pressure vessel steel.

  2. Benthic data from bottom grabs from Prince William Sound in support of Exxon Valdez Oil Spill Restoration Project from the R/V DAVIDSON and R/V BIG VALLEY from 03 July 1990 to 25 June of 1991 (NODC Accession 0000447)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Benthic samples and other data were collected from the R/V DAVIDSON and R/V BIG VALLEY from the Prince William Sound from 03 July 1990 to 25 June of 1991 . Data were...

  3. Strain hardening of aluminium alloy 3004 in the deep drawing and ironing processes

    International Nuclear Information System (INIS)

    Courbon, J.; Duval, J.L.

    1993-01-01

    The evolution of material hardening resulting from the canmaking operations on aluminium beverage cans has been investigated. Tensile tests in cup walls revealed that deep drawing induced softening in the hoop direction and hardening in the meridian direction. This anisotropy is retained in the ironing operation. Changes in strain path on a heavily cold-rolled material probably cause such a complex behaviour. To determine hardening laws for deep drawing, simple shear tests were thus performed because of the strain path similarity. They allowed to determine hardening laws over larger strains than tension could reach and revealed a saturation of stress. Altogether they proved adapted to the understanding of deep drawing. (orig.)

  4. Induction hardening of tool steel for heavily loaded aircraft engine components

    Directory of Open Access Journals (Sweden)

    Rokicki P.

    2017-03-01

    Full Text Available Induction hardening is an innovative process allowing modification of the materials surface with more effective, cheaper and more reproducible way to compare with conventional hardening methods used in the aerospace industry. Unfortunately, high requirements and strict regulation concerning this branch of the industry force deep research allowing to obtain results that would be used for numerical modelling of the process. Only by this way one is able to start the industrial application of the process. The main scope of presented paper are results concerning investigation of microstructure evolution of tool steel after single-frequency induction hardening process. The specimens that aim in representing final industrial products (as heavily loaded gears, were heat- -treated with induction method and subjected to metallographic preparation, after which complex microstructure investigation was performed. The results obtained within the research will be a basis for numerical modelling of the process of induction hardening with potential to be introduced for the aviation industrial components.

  5. The effects of induction hardening on wear properties of AISI 4140 steel in dry sliding conditions

    International Nuclear Information System (INIS)

    Totik, Y.; Sadeler, R.; Altun, H.; Gavgali, M.

    2002-01-01

    Wear behaviour of induction hardened AISI 4140 steel was evaluated under dry sliding conditions. Specimens were induction hardened at 1000 Hz for 6, 10, 14, 18, 27 s, respectively, in the inductor which was a three-turn coil with a coupling distance of 2.8 mm. Normalised and induction hardened specimens were fully characterised before and after the wear testing using hardness, profilometer, scanning electron microscopy and X-ray diffraction. The wear tests using a pin-on-disc machine showed that the induction hardening treatments improved the wear behaviour of AISI 4140 steel specimens compared to normalised AISI 4140 steel as a result of residual stresses and hardened surfaces. The wear coefficients in normalised specimens are greater than that in the induction hardened samples. The lowest coefficient of the friction was obtained in specimens induction-hardened at 875 deg. C for 27 s

  6. The effects of induction hardening on wear properties of AISI 4140 steel in dry sliding conditions

    Energy Technology Data Exchange (ETDEWEB)

    Totik, Y.; Sadeler, R.; Altun, H.; Gavgali, M

    2002-02-15

    Wear behaviour of induction hardened AISI 4140 steel was evaluated under dry sliding conditions. Specimens were induction hardened at 1000 Hz for 6, 10, 14, 18, 27 s, respectively, in the inductor which was a three-turn coil with a coupling distance of 2.8 mm. Normalised and induction hardened specimens were fully characterised before and after the wear testing using hardness, profilometer, scanning electron microscopy and X-ray diffraction. The wear tests using a pin-on-disc machine showed that the induction hardening treatments improved the wear behaviour of AISI 4140 steel specimens compared to normalised AISI 4140 steel as a result of residual stresses and hardened surfaces. The wear coefficients in normalised specimens are greater than that in the induction hardened samples. The lowest coefficient of the friction was obtained in specimens induction-hardened at 875 deg. C for 27 s.

  7. Simulating the influence of scatter and beam hardening in dimensional computed tomography

    Science.gov (United States)

    Lifton, J. J.; Carmignato, S.

    2017-10-01

    Cone-beam x-ray computed tomography (XCT) is a radiographic scanning technique that allows the non-destructive dimensional measurement of an object’s internal and external features. XCT measurements are influenced by a number of different factors that are poorly understood. This work investigates how non-linear x-ray attenuation caused by beam hardening and scatter influences XCT-based dimensional measurements through the use of simulated data. For the measurement task considered, both scatter and beam hardening are found to influence dimensional measurements when evaluated using the ISO50 surface determination method. On the other hand, only beam hardening is found to influence dimensional measurements when evaluated using an advanced surface determination method. Based on the results presented, recommendations on the use of beam hardening and scatter correction for dimensional XCT are given.

  8. Effect of ethephon on hardening of Pachystroma longifolium seedlings

    Directory of Open Access Journals (Sweden)

    João Alexandre Lopes Dranski

    2013-06-01

    Full Text Available Immediately after planting, tree seedlings face adverse environmental and biotic stresses that must be overcome to ensure survival and to yield a desirable growth. Hardening practices in the nursery may help improve seedling stress resistance through reduction of aboveground plant tissues and increased root volume and biomass. We conducted an assay to quantify changes in the morphogenesis following application of ethephon on seedlings of Pachystroma longifolium (Ness I. M. Johnst.during hardening. The results showed no effect of the ethephon treatments on the number of leaves but a reduction of up to 50% in seedling height increment, and an increase in stem diameter increment of up to 44% with the 600 mg L-1 ethephon treatment, which consequently altered seedling Dickson Quality Index. Our results indicate that ethephon may help to promote desired morphological changes that occur during seedling hardening in nurseries.

  9. Nutrients and physical data from the R/V Thomas Washington and the R/V Oshoru Maru using bottle and CTD casts as part of the Inner Shelf Transport and Recycling (ISHTAR) project from 12 June 1986 to 19 October 1988 (NODC Accession 0000333)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Nutrients and physical data were collected from the R/V THOMAS WASHINGTON and R/V OSHORU MARU from June 12, 1986 to October 19, 1988. Data were submitted by...

  10. The capability of pulsed laser radiation for cutting band saws hardening

    Directory of Open Access Journals (Sweden)

    Marinin Evgeny

    2017-01-01

    Full Text Available The article deals with the possibilities of pulsed laser radiation for hardening the band saws. The regimes of pulsed laser hardening the band saws of 1 mm thick made of tool steel 9CrV are grounded theoretically and experimentally tested. Selected and justified modes of treatment harden in the autohardening mode without additional heat removal. The results of the experimental research of microhardness are presented and formed as a result of processing of the microstructure. Selected modes increase the microhardness of the surface to 8500 MPa and form ultra highly dispersed structure in the surface layer characterized by high resistance to abrasion.

  11. EFFECT OF HARDENER ON MECHANICAL PROPERTIES OF CARBON FIBRE REINFORCED PHENOLIC RESIN COMPOSITES

    Directory of Open Access Journals (Sweden)

    S. SULAIMAN

    2008-04-01

    Full Text Available In this paper the effect of hardener on mechanical properties of carbon reinforced phenolic resin composites is investigated. Carbon fibre is one of the most useful reinforcement materials in composites, its major use being the manufacture of components in the aerospace, automotive, and leisure industries. In this study, carbon fibres are hot pressed with phenolic resin with various percentages of carbon fibre and hardener contents that range from 5-15%. Composites with 15% hardener content show an increase in flexural strength, tensile strength and hardness. The ultimate tensile strength (UTS, flexural strength and hardness for 15% hardener are 411.9 MPa, 51.7 MPa and 85.4 HRR respectively.

  12. idRHa+ProMod - Rail Hardening Control System

    International Nuclear Information System (INIS)

    Ferro, L

    2016-01-01

    idRHa+ProMod is the process control system developed by Primetals Technologies to foresee the thermo-mechanical evolution and micro-structural composition of rail steels subjected to slack quenching into idRHa+ Rail Hardening equipments in a simulation environment. This tool can be used both off-line or in-line, giving the user the chance to test and study the best cooling strategies or letting the automatic control system free to adjust the proper cooling recipe. Optimization criteria have been tailored in order to determine the best cooling conditions according to the metallurgical requirements imposed by the main rail standards and also taking into account the elastoplastic bending phenomena occurring during all stages of the head hardening process. The computational core of idRHa+ProMod is a thermal finite element procedure coupled with special algorithms developed to work out the main thermo-physical properties of steel, to predict the non-isothermal austenite decomposition into all the relevant phases and subsequently to evaluate the amount of latent heat of transformation released, the compound thermal expansion coefficient and the amount of plastic deformation in the material. Air mist and air blades boundary conditions have been carefully investigated by means of pilot plant tests aimed to study the jet impingement on rail surfaces and the cooling efficiency at all working conditions. Heat transfer coefficients have been further checked and adjusted directly on field during commissioning. idRHa+ is a trademark of Primetals Technologies Italy Srl (paper)

  13. idRHa+ProMod - Rail Hardening Control System

    Science.gov (United States)

    Ferro, L.

    2016-03-01

    idRHa+ProMod is the process control system developed by Primetals Technologies to foresee the thermo-mechanical evolution and micro-structural composition of rail steels subjected to slack quenching into idRHa+ Rail Hardening equipments in a simulation environment. This tool can be used both off-line or in-line, giving the user the chance to test and study the best cooling strategies or letting the automatic control system free to adjust the proper cooling recipe. Optimization criteria have been tailored in order to determine the best cooling conditions according to the metallurgical requirements imposed by the main rail standards and also taking into account the elastoplastic bending phenomena occurring during all stages of the head hardening process. The computational core of idRHa+ProMod is a thermal finite element procedure coupled with special algorithms developed to work out the main thermo-physical properties of steel, to predict the non-isothermal austenite decomposition into all the relevant phases and subsequently to evaluate the amount of latent heat of transformation released, the compound thermal expansion coefficient and the amount of plastic deformation in the material. Air mist and air blades boundary conditions have been carefully investigated by means of pilot plant tests aimed to study the jet impingement on rail surfaces and the cooling efficiency at all working conditions. Heat transfer coefficients have been further checked and adjusted directly on field during commissioning. idRHa+ is a trademark of Primetals Technologies Italy Srl

  14. Radiation hardening and embrittlement of some refractory metals and alloys

    International Nuclear Information System (INIS)

    Fabritsiev, S.; Pokrovskyb

    2007-01-01

    Tungsten is proposed for application in the ITER divertor and limiter as plasma facing material. The tungsten operation temperature in the ITER divertor is relatively high. Hence, the ductile properties of tungsten will be controlled by the low temperature radiation embrittlement. The mechanism of radiation hardening and embrittlement under neutron irradiation at low temperature is well studied for FCC metals, in particular for copper. At the same time, low-temperature radiation hardening of BCC materials, in particular for refractory metals, is less studied. This study presents the results of investigation into radiation hardening and embrittlement of pure metals: W, Mo and Nb, and W-Re and Ta-4W alloys. The materials were in the annealed conditions. The specimens were irradiated in the SM-2 reactor to doses of 10 -4 -10 -1 dpa at 80 C and then tested for tension at 80 C. The study of the stress-strain curves of unirradiated specimens revealed a yield drop for W, Mo, Nb, Ta-4W, W-Re. After the yield drop some metals (Mo,Nb) retain their capability for strain hardening and demonstrate a high elongation (20-50%). Radiation hardening is maximum in Mo (∝400MPa) and minimum in Nb (∝100 MPa). In this case the dependence slope for Nb is similar to that for pure copper irradiated in SM-2 under the same conditions. Ii and Ta-4W have a higher slope. Measurement of electrical resistivity of irradiated specimens showed that for all materials it is increased monotonously with an increase in the irradiation dose. A minimum gain in electrical resistivity with a dose was observed for Nb (∝3% at 0.1 dpa). As for Mo it was essentially higher, i.e. ∝ 30%. The gain was maximum for W-Re alloy. Comparison of radiation hardening dose dependencies obtained in this study with the data for FCC metals (Cu) showed that in spite of the quantitative difference the qualitative behavior of these two classes of metals is similar. (orig.)

  15. Effect of bainitic transformation on bake hardening in TRIP assisted steel

    International Nuclear Information System (INIS)

    Das, S.; Timokhina, I.; Singh, S.B.; Pereloma, E.; Mohanty, O.N.

    2012-01-01

    Highlights: ► Bainitic transformation in TRIP-assisted steel can lead to a very good bake hardening response as demonstrated by other researchers also. ► No extra deformation is needed. Dislocations can be generated in situ during the transformation itself. ► Detail characterisation and theoretical treatments showed bainite plates are sufficiently enriched with extra carbon atoms which can migrate and lock the dislocations. - Abstract: Bake hardening is a phenomenon where freshly generated dislocations get pinned down by the migrating carbon atoms under the influence of temperature employed in paint baking shop. Experimentally, a minimal 2% deformation is given to generate such new dislocations. On the other hand, after bainitic transformation, steel contains a large number of dislocations as well as excess carbon atoms in bainite, a combination of which is capable of producing bake hardening effect. In the current analysis, one grade of transformation induced plasticity aided steel was chosen to study the effect of isothermal bainitic transformation on subsequent bake hardening response, without giving any deformation assuming that the previous treatment would have generated sufficient dislocations which could be pinned down by the migrating carbon atoms under the influence of thermal treatment of the bake hardening process. The final microstructure was characterised by many techniques, using Thermo-Calc, optical microscopy, XRD analysis and 3-DAP. A good agreement was observed amongst all the techniques employed.

  16. Age-hardening susceptibility of high-Cr ODS ferritic steels and SUS430 ferritic steel

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Dongsheng, E-mail: chen.dongsheng85@gmail.com [Graduate School of Energy Science, Kyoto University, Gokasho, Uji, Kyoto 611-0011 (Japan); Kimura, Akihiko; Han, Wentuo; Je, Hwanil [Institute of Advanced Energy, Kyoto University, Gokasho, Uji, Kyoto 611-0011 (Japan)

    2015-10-15

    Highlights: • The role of oxide particles in α/α′ phase decomposition behavior; microstructure of phase decomposition observed by TEM. • The characteristics of ductility loss caused by age-hardening. • Correlation of phase decomposition and age-hardening explained by dispersion strengthened models. • Age-hardening susceptibility of ODS steels and SUS430 steel. - Abstract: The effect of aging on high-Cr ferritic steels was investigated with focusing on the role of oxide particles in α/α′ phase decomposition behavior. 12Cr-oxide dispersion strengthened (ODS) steel, 15Cr-ODS steel and commercial SUS430 steel were isothermally aged at 475 °C for up to 10,000 h. Thermal aging caused a larger hardening in SUS430 than 15Cr-ODS, while 12Cr-ODS showed almost no hardening. A characteristic of the ODS steels is that the hardening was not accompanied by the significant loss of ductility that was observed in SUS430 steel. After aging for 2000 h, SUS430 steel shows a larger ductile–brittle transition temperature (DBTT) shift than 15Cr-ODS steel, which suggests that the age-hardening susceptibility is lower in 15Cr-ODS steel than in conventional SUS430 steel. Thermal aging leaded to a large number of Cr-rich α′ precipitates, which were confirmed by transmission electron microscopy (TEM). Correlation of age-hardening and phase decomposition was interpreted by Orowan type strengthening model. Results indicate that oxide particles cannot only suppress ductility loss, but also may influence α/α′ phase decomposition kinetics.

  17. Application of the Single Hardening Model in the Finite Element Program ABAQUS

    DEFF Research Database (Denmark)

    Jakobsen, Kim Parsberg

    model, developed by Lade and Kim (Kim & Lade 1988, Lade & Kim 1988a, Lade & Kim 1988b) is implemented as a user defined material module, UMAT, in the commercial finite element program, ABAQUS. The advantages of the Single Hardening Model Iie in its ability to predict elastic and plastic displacements...

  18. Novel mechanism of gene regulation: the protein Rv1222 of Mycobacterium tuberculosis inhibits transcription by anchoring the RNA polymerase onto DNA.

    Science.gov (United States)

    Rudra, Paulami; Prajapati, Ranjit Kumar; Banerjee, Rajdeep; Sengupta, Shreya; Mukhopadhyay, Jayanta

    2015-07-13

    We propose a novel mechanism of gene regulation in Mycobacterium tuberculosis where the protein Rv1222 inhibits transcription by anchoring RNA polymerase (RNAP) onto DNA. In contrast to our existing knowledge that transcriptional repressors function either by binding to DNA at specific sequences or by binding to RNAP, we show that Rv1222-mediated transcription inhibition requires simultaneous binding of the protein to both RNAP and DNA. We demonstrate that the positively charged C-terminus tail of Rv1222 is responsible for anchoring RNAP on DNA, hence the protein slows down the movement of RNAP along the DNA during transcription elongation. The interaction between Rv1222 and DNA is electrostatic, thus the protein could inhibit transcription from any gene. As Rv1222 slows down the RNA synthesis, upon expression of the protein in Mycobacterium smegmatis or Escherichia coli, the growth rate of the bacteria is severely impaired. The protein does not possess any significant affinity for DNA polymerase, thus, is unable to inhibit DNA synthesis. The proposed mechanism by which Rv1222 inhibits transcription reveals a new repertoire of prokaryotic gene regulation. © Crown copyright 2015.

  19. Quantitative analysis of CT brain images: a statistical model incorporating partial volume and beam hardening effects

    International Nuclear Information System (INIS)

    McLoughlin, R.F.; Ryan, M.V.; Heuston, P.M.; McCoy, C.T.; Masterson, J.B.

    1992-01-01

    The purpose of this study was to construct and evaluate a statistical model for the quantitative analysis of computed tomographic brain images. Data were derived from standard sections in 34 normal studies. A model representing the intercranial pure tissue and partial volume areas, with allowance for beam hardening, was developed. The average percentage error in estimation of areas, derived from phantom tests using the model, was 28.47%. We conclude that our model is not sufficiently accurate to be of clinical use, even though allowance was made for partial volume and beam hardening effects. (author)

  20. Branching structure and strain hardening of branched metallocene polyethylenes

    International Nuclear Information System (INIS)

    Torres, Enrique; Li, Si-Wan; Costeux, Stéphane; Dealy, John M.

    2015-01-01

    There have been a number of studies of a series of branched metallocene polyethylenes (BMPs) made in a solution, continuous stirred tank reactor (CSTR) polymerization. The materials studied vary in branching level in a systematic way, and the most highly branched members of the series exhibit mild strain hardening. An outstanding question is which types of branched molecules are responsible for strain hardening in extension. This question is explored here by use of polymerization and rheological models along with new data on the extensional flow behavior of the most highly branched members of the set. After reviewing all that is known about the effects of various branching structures in homogeneous polymers and comparing this with the structures predicted to be present in BMPs, it is concluded that in spite of their very low concentration, treelike molecules with branch-on-branch structure provide a large number of deeply buried inner segments that are essential for strain hardening in these polymers

  1. Branching structure and strain hardening of branched metallocene polyethylenes

    Energy Technology Data Exchange (ETDEWEB)

    Torres, Enrique; Li, Si-Wan; Costeux, Stéphane; Dealy, John M., E-mail: john.dealy@mcgill.ca [Department of Chemical Engineering, McGill University, Montreal, Quebec H3A 0C4 (Canada)

    2015-09-15

    There have been a number of studies of a series of branched metallocene polyethylenes (BMPs) made in a solution, continuous stirred tank reactor (CSTR) polymerization. The materials studied vary in branching level in a systematic way, and the most highly branched members of the series exhibit mild strain hardening. An outstanding question is which types of branched molecules are responsible for strain hardening in extension. This question is explored here by use of polymerization and rheological models along with new data on the extensional flow behavior of the most highly branched members of the set. After reviewing all that is known about the effects of various branching structures in homogeneous polymers and comparing this with the structures predicted to be present in BMPs, it is concluded that in spite of their very low concentration, treelike molecules with branch-on-branch structure provide a large number of deeply buried inner segments that are essential for strain hardening in these polymers.

  2. A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography.

    Science.gov (United States)

    Bunker, Richard D; Mandal, Kalyaneswar; Bashiri, Ghader; Chaston, Jessica J; Pentelute, Bradley L; Lott, J Shaun; Kent, Stephen B H; Baker, Edward N

    2015-04-07

    Protein 3D structure can be a powerful predictor of function, but it often faces a critical roadblock at the crystallization step. Rv1738, a protein from Mycobacterium tuberculosis that is strongly implicated in the onset of nonreplicating persistence, and thereby latent tuberculosis, resisted extensive attempts at crystallization. Chemical synthesis of the L- and D-enantiomeric forms of Rv1738 enabled facile crystallization of the D/L-racemic mixture. The structure was solved by an ab initio approach that took advantage of the quantized phases characteristic of diffraction by centrosymmetric crystals. The structure, containing L- and D-dimers in a centrosymmetric space group, revealed unexpected homology with bacterial hibernation-promoting factors that bind to ribosomes and suppress translation. This suggests that the functional role of Rv1738 is to contribute to the shutdown of ribosomal protein synthesis during the onset of nonreplicating persistence of M. tuberculosis.

  3. Design considerations for a radiation hardened nonvolatile memory

    International Nuclear Information System (INIS)

    Murray, J.R.

    1993-01-01

    Sub-optimal design practices can reduce the radiation hardness of a circuit even though it is fabricated in a radiation hardened process. This is especially true for a nonvolatile memory, as compared to a standard digital circuit, where high voltages and unusual bias conditions are required. This paper will discuss the design technique's used in the development of a 64K EEPROM (Electrically Erasable Programmable Read Only Memory) to maximize radiation hardness. The circuit radiation test results will be reviewed in order to provide validation of the techniques

  4. Treatment of marine sewage pumpout and RV park pumpout wastewater containing high strength concentrations of formaldehyde

    International Nuclear Information System (INIS)

    Salonich, J.

    2002-01-01

    'Full text:' A consortium of companies has developed an integrated 'on-site' wastewater treatment technology that is capable of handling and degrading RV Park and Marine Sewage Pumpout Wastes which contain formaldehyde [35 - 80 mg/L]. Boat and RV owners add formaldehyde to their toilets to eliminate odors. When these materials are pumped out they are high in solids content and have high concentrations of HCHO, which makes them difficult to degrade at POTWs. At the heart of this process is 1. An aeration tank with a Venturi Aerator totally external to the tank and 2. The addition of a blend of cultured bacteria that have selected for their ability to degrade formaldehyde. For a complete 'on-site' treatment system Bioclere Trickling Filters can follow this aeration/bacterial treatment system. This is an ideal system configuration for remote locations (RV Parks) or for fresh water lake Marinas looking to reduce their disposal costs and for groundwater discharge with no adverse effect on water quality. Until the development of the formaldehyde degrading bacteria for an industrial wastewater process there were no cultures commercially available specifically for degrading formaldehyde. The most commonly used bacteria were pseudomonas strains for carbohydrate or hydrocarbon wastewater extracted from activated sludge plants. And since formaldehyde is infinitely soluble in a liquid it is difficult to degrade or mineralize. The process in an activated sludge WWTP plant took over 72 hours. With the newly selected consortia of cultures, HCHO can be degraded in 12-14 hours on a batch basis. This is accomplished in a uniquely configured aeration tank where the 'environment' of the tank is constantly conditioned by a Venturi Aerator which strips carbon dioxide generated by the aerobes to maintain a neutral pH, and provide high levels of DO (>5.0 mg/L) to keep the process aerobic. (author)

  5. Integrity evaluation of Alloy 600 RV head penetration tubes in Korean PWR plants

    International Nuclear Information System (INIS)

    Kang, Young Hwan; Park, Sung Ho; Hong, Sung Yull; Choi, Kwang Hee

    1995-01-01

    The structural integrity assessment of Alloy 600 RV head penetration tubes has been an important issue for the economical and reliable operation of power plants. In this paper, an overview of the integrity evaluation program for the RV head penetration tubes in Korean nuclear power plants is presented. Since the crack growth mechanism of the penetration tube is due to the primary water stress corrosion cracking (PWSCC) which is mainly related to the stress at the tube, the present paper consists of three primary activities: the stress evaluation, the flaw evaluation, and data generation through material and mechanical tests. (author). 5 refs, 2 figs, 1 tab

  6. Microstructural evolution and the variation of tensile behavior after aging heat treatment of precipitation hardened martensitic steel

    International Nuclear Information System (INIS)

    Shin, Jong-Ho; Jeong, JaeSuk; Lee, Jong-Wook

    2015-01-01

    The effects of aging temperature on the microstructural evolution and the tensile behavior of precipitation hardened martensitic steel were investigated. Microscopic analysis using transmission electron microscope (TEM) was combined with the microstructural analysis using the synchrotron X-ray diffraction (XRD) to characterize the microstructural evolution with aging temperature. Peak hardness was obtained by precipitation of the Ni 3 Al ordered phase. After aging at temperature range from 420 to 590 °C, spherical Ni 3 Al precipitates and ellipsoidal M 23 C 6 carbides were observed within laths and at lath boundaries, respectively. Strain hardening behavior was analyzed with Ludwik equation. It is observed that the plastic strain regimes can be divided into two different stages by a rapid increase in strain hardening followed by a comparatively lower increase. At the first strain hardening stage, the aged specimen exhibited higher strain hardening exponent than the as-quenched specimen, and the exponent in the aged specimen was not changed considerably with increasing aging temperature. It is revealed that the strain hardening exponents at the first and the second stages were associated with the Ni 3 Al precipitates and the domain size representing the coherent scattering area, respectively. - Highlights: • All of aged specimen exhibited higher strain hardening exponent than the as-quenched specimen at the first stage. • The value of strain hardening exponent in the aged specimen was nearly constant with aging temperature. • Ni 3 Al precipitation dominantly influenced to the increase of strain hardening exponent at the first strain hardening stage. • Domain size was associated with strain hardening exponent at the second strain hardening stage

  7. Microstructural evolution and the variation of tensile behavior after aging heat treatment of precipitation hardened martensitic steel

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Jong-Ho, E-mail: jongho.shin@doosan.com [Casting and Forging Technology Development Team, Doosan Heavy Industries and Construction, 22 Doosanvolvo-ro, Changwon 642-792 (Korea, Republic of); Jeong, JaeSuk [Materials and Manufacturing Development Team, Doosan Heavy Industries and Construction, 22 Doosanvolvo-ro, Changwon 642-792 (Korea, Republic of); Lee, Jong-Wook [Casting and Forging Technology Development Team, Doosan Heavy Industries and Construction, 22 Doosanvolvo-ro, Changwon 642-792 (Korea, Republic of)

    2015-01-15

    The effects of aging temperature on the microstructural evolution and the tensile behavior of precipitation hardened martensitic steel were investigated. Microscopic analysis using transmission electron microscope (TEM) was combined with the microstructural analysis using the synchrotron X-ray diffraction (XRD) to characterize the microstructural evolution with aging temperature. Peak hardness was obtained by precipitation of the Ni{sub 3}Al ordered phase. After aging at temperature range from 420 to 590 °C, spherical Ni{sub 3}Al precipitates and ellipsoidal M{sub 23}C{sub 6} carbides were observed within laths and at lath boundaries, respectively. Strain hardening behavior was analyzed with Ludwik equation. It is observed that the plastic strain regimes can be divided into two different stages by a rapid increase in strain hardening followed by a comparatively lower increase. At the first strain hardening stage, the aged specimen exhibited higher strain hardening exponent than the as-quenched specimen, and the exponent in the aged specimen was not changed considerably with increasing aging temperature. It is revealed that the strain hardening exponents at the first and the second stages were associated with the Ni{sub 3}Al precipitates and the domain size representing the coherent scattering area, respectively. - Highlights: • All of aged specimen exhibited higher strain hardening exponent than the as-quenched specimen at the first stage. • The value of strain hardening exponent in the aged specimen was nearly constant with aging temperature. • Ni{sub 3}Al precipitation dominantly influenced to the increase of strain hardening exponent at the first strain hardening stage. • Domain size was associated with strain hardening exponent at the second strain hardening stage.

  8. Influence of cyclic temperature changes on the microstructure of AISI 4140 after laser surface hardening

    International Nuclear Information System (INIS)

    Miokovic, T.; Schulze, V.; Voehringer, O.; Loehe, D.

    2007-01-01

    In recent years laser surface hardening using pulsed laser sources has become an increasingly established technology in engineering industry and has opened up wider possibilities for the application of selective surface hardening. However, the choice of the process parameters is generally based on experience rather than on their empirical influence on the resulting microstructure, and for hardening processes with cyclic temperature changes, almost no correlations between process parameters and hardening results are known. Therefore, some problems regarding the choice of the process parameters and their influence on the resulting microstructure still remain. In particular, there is a lack of data concerning the effect of cyclic temperature changes on hardening. To facilitate process optimization, this paper deals with a detailed characterization of the microstructures created in quenched and tempered AISI 4140 (German grade 42CrMo4) steel following a temperature-dependent laser surface hardening treatment. The structure properties were obtained from microhardness measurements, scanning electron microscopy investigations and X-ray diffraction analysis of retained austenite

  9. Influence of cyclic temperature changes on the microstructure of AISI 4140 after laser surface hardening

    Energy Technology Data Exchange (ETDEWEB)

    Miokovic, T. [Institute of Materials Science and Engineering I, University of Karlsruhe, 76131 Karlsruhe (Germany); Schulze, V. [Institute of Materials Science and Engineering I, University of Karlsruhe, 76131 Karlsruhe (Germany)]. E-mail: volker.schulze@mach.uni-karlsruhe.de; Voehringer, O. [Institute of Materials Science and Engineering I, University of Karlsruhe, 76131 Karlsruhe (Germany); Loehe, D. [Institute of Materials Science and Engineering I, University of Karlsruhe, 76131 Karlsruhe (Germany)

    2007-01-15

    In recent years laser surface hardening using pulsed laser sources has become an increasingly established technology in engineering industry and has opened up wider possibilities for the application of selective surface hardening. However, the choice of the process parameters is generally based on experience rather than on their empirical influence on the resulting microstructure, and for hardening processes with cyclic temperature changes, almost no correlations between process parameters and hardening results are known. Therefore, some problems regarding the choice of the process parameters and their influence on the resulting microstructure still remain. In particular, there is a lack of data concerning the effect of cyclic temperature changes on hardening. To facilitate process optimization, this paper deals with a detailed characterization of the microstructures created in quenched and tempered AISI 4140 (German grade 42CrMo4) steel following a temperature-dependent laser surface hardening treatment. The structure properties were obtained from microhardness measurements, scanning electron microscopy investigations and X-ray diffraction analysis of retained austenite.

  10. The surface fatigue life of contour induction hardened AISI 1552 gears

    Science.gov (United States)

    Townsend, Dennis P.; Turza, Alan; Chaplin, Mike

    1995-07-01

    Two groups of spur gears manufactured from two different materials and heat treatments were endurance tested for surface fatigue life. One group was manufactured from AISI 1552 and was finished ground to a 0.4 micron (16 micro-in.) rms surface finish and then dual frequency contour induction hardened. The second group was manufactured from CEVM AISI 9310 and was carburized, hardened, and ground to a 0.4 micron (16 micro-in.) rms surface finish. The gear pitch diameter was 8.89 cm (3.5 in.). Test conditions were a maximum Hertz stress of 1.71 GPa (248 ksi), a bulk gear temperature of approximately 350 K (170 F) and a speed of 10,000 rpm. The lubricant used for the tests was a synthetic paraffinic oil with an additive package. The test results showed that the 10 percent surface fatigue (pitting) life of the contour hardened AISI 1552 test gears was 1.7 times that of the carburized and hardened AISI 9310 test gears. Also there were two early failures of the AISI 1552 gears by bending fatigue.

  11. Mechanism of Secondary Hardening in Rapid Tempering of Dual-Phase Steel

    Science.gov (United States)

    Saha, Dulal Chandra; Nayak, Sashank S.; Biro, Elliot; Gerlich, Adrian P.; Zhou, Y.

    2014-12-01

    Dual-phase steel with ferrite-martensite-bainite microstructure exhibited secondary hardening in the subcritical heat affected zone during fiber laser welding. Rapid isothermal tempering conducted in a Gleeble simulator also indicated occurrence of secondary hardening at 773 K (500 °C), as confirmed by plotting the tempered hardness against the Holloman-Jaffe parameter. Isothermally tempered specimens were characterized by analytic transmission electron microscopy and high-angle annular dark-field imaging. The cementite (Fe3C) and TiC located in the bainite phase of DP steel decomposed upon rapid tempering to form needle-shaped Mo2C (aspect ratio ranging from 10 to 25) and plate-shaped M4C3 carbides giving rise to secondary hardening. Precipitation of these thermodynamically stable and coherent carbides promoted the hardening phenomenon. However, complex carbides were only seen in the tempered bainite and were not detected in the tempered martensite. The martensite phase decomposed into ferrite and spherical Fe3C, and interlath-retained austenite decomposed into ferrite and elongated carbide.

  12. Radiation hardening coating material

    International Nuclear Information System (INIS)

    McDonald, W.H.; Prucnal, P.J.; DeMajistre, Robert.

    1977-01-01

    This invention concerns a radiation hardening coating material. First a resin is prepared by reaction of bisphenol diglycidylic ether with acrylic or methacrylic acids. Then the reactive solvent is prepared by reaction of acrylic or methacrylic acids with epichlorhydrine or epibromhydrine. Then a solution consisting of the resin dissolved in the reactive solvent is prepared. A substrate (wood, paper, polyesters, polyamines etc.) is coated with this composition and exposed to ionizing radiations (electron beams) or ultraviolet radiations [fr

  13. Fatigue of coated and laser hardened steels

    International Nuclear Information System (INIS)

    La Cruz, P. de.

    1990-01-01

    In the present work the effect of ion nitriding, laser hardening and hot dip galvanizing upon the fatigue limit and notch sensitivity of a B-Mn Swedish steel SS 2131 have been investigated. The fatigue tests were performed in plane reverse bending fatigue (R=1). The quenched and tempered condition was taken as the reference condition. The microstructure, microhardness, fracture surface and coating appearance of the fatigue surface treated specimens were studied. Residual stress and retained austenite measurements were also carried out. It was found that ion nitriding improves the fatigue limit by 53 % for smooth specimens and by 115 % for notched specimens. Laser hardening improves the fatigue limit by 18 % and 56 % for smooth and notched specimen respectively. Hot dip galvanizing gives a slight deterioration of the fatigue limit (9 % and 10 % for smooth and notched specimen respectively). Ion nitriding and laser hardening decrease the value of the notch sensitivity factor q by 78 % and 65 % respectively. Hot dip galvanizing does not modify it. A simple schematic model based on a residual stress distribution, has been used to explain the different effects. It seems that the presence of the higher compressive residual stresses and the higher uniformity of the microstructure may be the causes of the better fatigue performance of ion nitrided specimens. (119 refs.) (author)

  14. Radiation-hardened MRAM-based LUT for non-volatile FPGA soft error mitigation with multi-node upset tolerance

    Science.gov (United States)

    Zand, Ramtin; DeMara, Ronald F.

    2017-12-01

    In this paper, we have developed a radiation-hardened non-volatile lookup table (LUT) circuit utilizing spin Hall effect (SHE)-magnetic random access memory (MRAM) devices. The design is motivated by modeling the effect of radiation particles striking hybrid complementary metal oxide semiconductor/spin based circuits, and the resistive behavior of SHE-MRAM devices via established and precise physics equations. The models developed are leveraged in the SPICE circuit simulator to verify the functionality of the proposed design. The proposed hardening technique is based on using feedback transistors, as well as increasing the radiation capacity of the sensitive nodes. Simulation results show that our proposed LUT circuit can achieve multiple node upset (MNU) tolerance with more than 38% and 60% power-delay product improvement as well as 26% and 50% reduction in device count compared to the previous energy-efficient radiation-hardened LUT designs. Finally, we have performed a process variation analysis showing that the MNU immunity of our proposed circuit is realized at the cost of increased susceptibility to transistor and MRAM variations compared to an unprotected LUT design.

  15. Effect of ferrite-martensite interface morphology on bake hardening response of DP590 steel

    International Nuclear Information System (INIS)

    Chakraborty, Arnab; Adhikary, Manashi; Venugopalan, T.; Singh, Virender; Nanda, Tarun; Kumar, B. Ravi

    2016-01-01

    The effect of martensite spatial distribution and its interface morphology on the bake hardening characteristics of a dual phase steel was investigated. In one case, typical industrial continuous annealing line parameters were employed to anneal a 67% cold rolled steel to obtain a dual phase microstructure. In the other case, a modified annealing process with changed initial heating rates and peak annealing temperature was employed. The processed specimens were further tensile pre-strained within 1–5% strain range followed by a bake hardening treatment at 170 °C for 20 min. It was observed that industrial continuous annealing line processed specimen showed a peak of about 70 MPa in bake-hardening index at 2% pre-strain level. At higher pre-strain values a gradual drop in bake-hardening index was observed. On the contrary, modified annealing process showed near uniform bake-hardening response at all pre-strain levels and a decrease could be noted only above 4% pre-strain. The evolving microstructure at each stage of annealing process and after bake-hardening treatment was studied using field emission scanning electron microscope. The microstructure analysis distinctly revealed differences in martensite spatial distribution and interface morphologies between each annealing processes employed. The modified process showed predominant formation of martensite within the ferrite grains with serrated lath martensite interfaces. This nature of the martensite was considered responsible for the observed improvement in the bake-hardening response. Furthermore, along with improved bake-hardening response negligible loss in tensile ductility was also noted. This behaviour was correlated with delayed micro-crack initiation at martensite interface due to serrated nature.

  16. THE MECHANISM OF HARDENING OF ALLOYED STEELS IN IMPULSE MAGNETIC FIELD

    Directory of Open Access Journals (Sweden)

    A. V. Alifanov

    2012-01-01

    Full Text Available In this paper, a model describing the mechanism of hardening steels in a pulsed magnetic field is provided. The model is based on the consideration of induction currents in the grain bulk ferrite, on the surface of the workpiece near the inductor. The influence of doping efficiency of the process of hardening is established.

  17. Influence of coolant motion on structure of hardened steel element

    Directory of Open Access Journals (Sweden)

    A. Kulawik

    2008-08-01

    Full Text Available Presented paper is focused on volumetric hardening process using liquid low melting point metal as a coolant. Effect of convective motion of the coolant on material structure after hardening is investigated. Comparison with results obtained for model neglecting motion of liquid is executed. Mathematical and numerical model based on Finite Element Metod is described. Characteristic Based Split (CBS method is used to uncouple velocities and pressure and finally to solve Navier-Stokes equation. Petrov-Galerkin formulation is employed to stabilize convective term in heat transport equation. Phase transformations model is created on the basis of Johnson-Mehl and Avrami laws. Continuous cooling diagram (CTPc for C45 steel is exploited in presented model of phase transformations. Temporary temperatures, phases participation, thermal and structural strains in hardening element and coolant velocities are shown and discussed.

  18. Structural characterisation of oxygen diffusion hardened alpha-tantalum PVD-coatings on titanium.

    Science.gov (United States)

    Hertl, C; Koll, L; Schmitz, T; Werner, E; Gbureck, U

    2014-08-01

    Titanium substrates were coated with tantalum layers of 5 μm thickness using physical vapour deposition (PVD). The tantalum layers showed a (110)-preferred orientation. The coated samples were hardened by oxygen diffusion. Using X-ray diffraction the crystallographic structure of the tantalum coatings was characterised, comparing untreated and diffusion hardened specimen conditions. Oxygen depth profiles were determined by glow discharge spectrometry. The hardening effect of the heat treatment was examined by Vickers microhardness testing. The increase of surface hardness caused by oxygen diffusion was at least 50%. Copyright © 2014 Elsevier B.V. All rights reserved.

  19. Mycothiol acetyltransferase (Rv0819) of Mycobacterium tuberculosis is a potential biomarker for direct diagnosis of tuberculosis using patient serum specimens.

    Science.gov (United States)

    Zeitoun, H; Bahey-El-Din, M; Kassem, M A; Aboushleib, H M

    2017-12-01

    Mycobacterium tuberculosis infection constitutes a global threat that results in significant morbidity and mortality worldwide. Efficient and early diagnosis of tuberculosis (TB) is of paramount importance for successful treatment. The aim of the current study is to investigate the mycobacterial mycothiol acetyltransferase Rv0819 as a potential novel biomarker for the diagnosis of active TB infection. The gene encoding Rv0819 was cloned and successfully expressed in Escherichia coli. The recombinant Rv0819 was purified using metal affinity chromatography and was used to raise murine polyclonal antibodies against Rv0819. The raised antibodies were employed for direct detection of Rv0819 in patient serum samples using dot blot assay and competitive enzyme-linked immunosorbent assay (ELISA). Serum samples were obtained from 68 confirmed new TB patients and 35 healthy volunteers as negative controls. The dot blot assay showed sensitivity of 64·7% and specificity of 100%, whereas the competitive ELISA assay showed lower sensitivity (54·4%) and specificity (88·57%). The overall sensitivity of the combined results of the two tests was found to be 89·7%. Overall, the mycobacterial Rv0819 is a potential TB serum biomarker that can be exploited, in combination with other TB biomarkers, for efficient and reliable diagnosis of active TB infection. The early and accurate diagnosis of tuberculosis infection is of paramount importance for initiating treatment and avoiding clinical complications. Most current diagnostic tests have poor sensitivity and/or specificity and in many cases they are too expensive for routine diagnostic testing in resource-limited settings. In the current study, we examined a novel mycobacterial serum biomarker, namely mycothiol acetyltransferase Rv0819. The antigen was detectable in serum specimens of a significant number of tuberculosis patients. This article proves the importance of Rv0819 and paves the way towards its future use as a useful

  20. On the Spectral Hardening at gsim300 keV in Solar Flares

    Science.gov (United States)

    Li, G.; Kong, X.; Zank, G.; Chen, Y.

    2013-05-01

    It has long been noted that the spectra of observed continuum emissions in many solar flares are consistent with double power laws with a hardening at energies gsim300 keV. It is now widely believed that at least in electron-dominated events, the hardening in the photon spectrum reflects an intrinsic hardening in the source electron spectrum. In this paper, we point out that a power-law spectrum of electrons with a hardening at high energies can be explained by the diffusive shock acceleration of electrons at a termination shock with a finite width. Our suggestion is based on an early analytical work by Drury et al., where the steady-state transport equation at a shock with a tanh profile was solved for a p-independent diffusion coefficient. Numerical simulations with a p-dependent diffusion coefficient show hardenings in the accelerated electron spectrum that are comparable with observations. One necessary condition for our proposed scenario to work is that high-energy electrons resonate with the inertial range of the MHD turbulence and low-energy electrons resonate with the dissipation range of the MHD turbulence at the acceleration site, and the spectrum of the dissipation range ~k -2.7. A ~k -2.7 dissipation range spectrum is consistent with recent solar wind observations.

  1. Effects of solute elements on hardening of thermally-aged RPV model alloys

    International Nuclear Information System (INIS)

    Dohi, Kenji; Nishida, Kenji; Nomoto, Akiyoshi; Soneda, Naoki; Liu, Li; Sekimura, Naoto; Li Zhengcao

    2012-01-01

    The investigation of effects of solute elements on the copper-enriched cluster, which is a cause of radiation embrittlement of reactor pressure vessel steels, is needed in order to understand the mechanism of the hardening and the cluster formation. The dependence of the hardness change and the formation of thermally-aged Fe-Cu model alloys doped Ni, Si and Mn on aging time are investigated using Vickers harness tester and three dimensional atom probe. Ni addition suppresses hardening, and Si addition accelerates hardening slightly at the initial stage of the aging. Mn addition accelerates hardening much more but does not almost affect the peak hardness. Ni and Si addition increase the number density and the size of the cluster, while Mn addition remarkably increases the number density and the size of the cluster at the initial stage of the aging. In addition, there is no clear correlation between the square root of the volume fraction of the clusters and the hardness change for all of the alloys. The reasons are considered to be the decrease in the solute hardening caused by the cluster formation and the difference in the shear modulus of the cluster due to the difference in the chemical composition of the cluster. (author)

  2. Microalloying in case hardening steels - a challenge for the lean production of gears

    Energy Technology Data Exchange (ETDEWEB)

    Trute, S.; Bleck, W. [RWTH Aachen (Germany). Dept. of Ferrous Metallurgy; Hippenstiel, F. [Edelstahlwerke Buderus AG, Wetzlar (Germany); Klinkenberg, C. [Niobium Products Company GmbH, Duesseldorf (Germany)

    2005-07-01

    Case hardening steels cover a dominant fraction of engineering steel production. Particularly with recent developments in automotive power train elements, where good hardenability, high tensile strength, high fatigue strength and high impact resistance are required. With a share of up to 40% the material and the heat treatment process take a main part of the overall manufacturing costs. Production costs can be reduced by shortening the overall process time from the melting to the finishing. New developments in carburising technology with an increased carburising temperature offer the possibility of time and cost reduction. Simultaneously a precise grain size control during austenitising is required. A homogenous former austenite grain size distribution results in a more uniform performance of the mechanical properties. This paper summarizes the results of recent research regarding the demands on steels for a high temperature carburising process. The possibility to prevent undesired grain growth by increasing the grain coarsening temperature using microalloying elements as well as the impact on the production process is discussed. (orig.)

  3. Effect of bainitic transformation on bake hardening in TRIP assisted steel

    Energy Technology Data Exchange (ETDEWEB)

    Das, S., E-mail: sourav.das@tatasteel.com [Research and Development, Tata Steel Limited, Jamshedpur (India); Timokhina, I. [Centre for Material and Fibre Innovation/Science and Technology, Deakin University (Australia); Singh, S.B. [Metallurgical and Materials Engineering, IIT Kharagpur (India); Pereloma, E. [BlueScope Steel Metallurgy Centre, University of Wollongong (Australia); Mohanty, O.N. [RSB Metaltech, RSB Group, Jamshedpur (India)

    2012-02-01

    Highlights: Black-Right-Pointing-Pointer Bainitic transformation in TRIP-assisted steel can lead to a very good bake hardening response as demonstrated by other researchers also. Black-Right-Pointing-Pointer No extra deformation is needed. Dislocations can be generated in situ during the transformation itself. Black-Right-Pointing-Pointer Detail characterisation and theoretical treatments showed bainite plates are sufficiently enriched with extra carbon atoms which can migrate and lock the dislocations. - Abstract: Bake hardening is a phenomenon where freshly generated dislocations get pinned down by the migrating carbon atoms under the influence of temperature employed in paint baking shop. Experimentally, a minimal 2% deformation is given to generate such new dislocations. On the other hand, after bainitic transformation, steel contains a large number of dislocations as well as excess carbon atoms in bainite, a combination of which is capable of producing bake hardening effect. In the current analysis, one grade of transformation induced plasticity aided steel was chosen to study the effect of isothermal bainitic transformation on subsequent bake hardening response, without giving any deformation assuming that the previous treatment would have generated sufficient dislocations which could be pinned down by the migrating carbon atoms under the influence of thermal treatment of the bake hardening process. The final microstructure was characterised by many techniques, using Thermo-Calc, optical microscopy, XRD analysis and 3-DAP. A good agreement was observed amongst all the techniques employed.

  4. Radiation Hardened 10BASE-T Ethernet Physical Layer (PHY)

    Science.gov (United States)

    Lin, Michael R. (Inventor); Petrick, David J. (Inventor); Ballou, Kevin M. (Inventor); Espinosa, Daniel C. (Inventor); James, Edward F. (Inventor); Kliesner, Matthew A. (Inventor)

    2017-01-01

    Embodiments may provide a radiation hardened 10BASE-T Ethernet interface circuit suitable for space flight and in compliance with the IEEE 802.3 standard for Ethernet. The various embodiments may provide a 10BASE-T Ethernet interface circuit, comprising a field programmable gate array (FPGA), a transmitter circuit connected to the FPGA, a receiver circuit connected to the FPGA, and a transformer connected to the transmitter circuit and the receiver circuit. In the various embodiments, the FPGA, transmitter circuit, receiver circuit, and transformer may be radiation hardened.

  5. Exploration of a radiation hardening stabilized voltage power supply

    International Nuclear Information System (INIS)

    Xie Zeyuan; Xu Xianguo

    2014-01-01

    This paper mainly introduces the design method of radiation hardening stabilized voltage power supply that makes use of commercial radiation resistant electronic devices and the test results of radiation performance of the power supply and devices are presented in detail. The experiment results show that the hardened power supply can normally work until 1000 Gy (Si) total dose and 1 × 10 14 n/cm 2 neutron radiation, and it doesn't latchup at about 1 × l0 9 Gy (Si)/s gamma transient dose rate. (authors)

  6. Hardening and softening analysis of pure titanium based on the dislocation density during torsion deformation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Han; Li, Fuguo, E-mail: fuguolx@nwpu.edu.cn; Li, Jinghui; Ma, Xinkai; Li, Jiang; Wan, Qiong

    2016-08-01

    The hardening and softening phenomena during torsion deformation are studied based on the Taylor dislocation model for pure titanium. The hardening and softening phenomena are observed through the hardness analysis during micro-indentation test and micro-hardness test. Besides, the variations of indentation size also verify the existence of hardening and softening phenomena during torsion. The variations of geometric necessary dislocations (GNDs) and statistic store dislocations (SSDs) state that the positions of high dislocation density and low dislocation density correspond to the positions of hardening and softening. The results from the microstructure, grain boundaries evolution and twins analysis indicate the twins play an important role in appearance of hardening and softening phenomena. The appearance of hardening and softening phenomena are attributed to the combination of different slip systems and twinning systems combining with the Schmid Factor (SF) analysis and the transmission electron microscope (TEM). The appearance of hardening and softening phenomena can be explained by the Taylor dislocation theory based on TEM analysis. - Highlights: • The phenomena can be characterized by Taylor dislocation model. • The variation of GNDs leads to the phenomena. • The phenomena are proved by micro-hardness, indentation hardness. • The {10-12} twin and {11-24} twin play an important role in the phenomena.

  7. Identification of Rv0222 from RD4 as a novel serodiagnostic target for tuberculosis

    DEFF Research Database (Denmark)

    Rosenkrands, Ida; Aagaard, Claus; Weldingh, Karin

    2008-01-01

    tuberculosis patients and healthy controls led to identification of Rv0222 as the most promising serodiagnostic antigen. Recognition of the Rv0222 was compared with the 38 kDa protein and a fusion protein of the RD1 proteins ESAT-6 and CFP10 in a serum panel from pulmonary tuberculosis (TB) patients from......Forty-seven Mycobacterium tuberculosis genes from the 'regions of difference' RD2-7, RD9-13 and RD15 were cloned and expressed, and the purified recombinant proteins were screened for their serodiagnostic potential. Evaluation of six selected proteins in serum samples from Danish resident...

  8. Det Digitale Nærvær

    DEFF Research Database (Denmark)

    Heilesen, Simon

    Computer-medieret kommunikation (CMC – via intranet- og internet, ”allestedsnærværende computing” mm. ), er grundlaget for det informations- og videnssamfund, der begynder at tage form i disse år. CMC er blevet kolossalt udbredt de seneste 10 – 15 år og har forandret den måde vi udsender og søger...... information, kommunikerer med hinanden både privat og i organisationer, samarbejder, underviser og tilegner os viden. Denne bog går tæt på tre udvalgte områder inden for den computer-medierede kommunikation: · Videndeling i formelle og uformelle organisationer, · Netbaseret samarbejde og læring, · Design af...

  9. Beam-hardening correction in CT based on basis image and TV model

    International Nuclear Information System (INIS)

    Li Qingliang; Yan Bin; Li Lei; Sun Hongsheng; Zhang Feng

    2012-01-01

    In X-ray computed tomography, the beam hardening leads to artifacts and reduces the image quality. It analyzes how beam hardening influences on original projection. According, it puts forward a kind of new beam-hardening correction method based on the basis images and TV model. Firstly, according to physical characteristics of the beam hardening an preliminary correction model with adjustable parameters is set up. Secondly, using different parameters, original projections are operated by the correction model. Thirdly, the projections are reconstructed to obtain a series of basis images. Finally, the linear combination of basis images is the final reconstruction image. Here, with total variation for the final reconstruction image as the cost function, the linear combination coefficients for the basis images are determined according to iterative method. To verify the effectiveness of the proposed method, the experiments are carried out on real phantom and industrial part. The results show that the algorithm significantly inhibits cup and strip artifacts in CT image. (authors)

  10. Literature survey on phase composition of hardened cement paste containing fly ash

    International Nuclear Information System (INIS)

    Otsuka, Taku; Yamamoto, Takeshi

    2015-01-01

    The purpose of this literature survey is to collect the knowledge on the effect of fly ash in hardened cement paste and the information about evaluation of physicochemical performance based on phase composition of hardened cement paste. The performance of hardened cement paste containing fly ash is affected by the property of fly ash, hydration of cement and pozzolanic reaction of fly ash. Some properties of fly ash such as density and chemical composition are reflected in phase composition, showing the progress of cement hydration and pozzolanic reaction. Therefore clarification of the relationship of phase composition and performance will lead to appropriate evaluation of the property of fly ash. The amount of pore, chemical shrinkage, pore solution, compressive strength, Young modulus and alkali silica reaction have relations to the phase composition of hardened cement paste. It is considered as future subject to clarify the relationship of phase composition and performance for various properties of fly ash. (author)

  11. Rotavirus specific maternal antibodies and immune response to RV3-BB neonatal rotavirus vaccine in New Zealand

    Science.gov (United States)

    Chen, Mee-Yew; Kirkwood, Carl D.; Bines, Julie; Cowley, Daniel; Pavlic, Daniel; Lee, Katherine J.; Orsini, Francesca; Watts, Emma; Barnes, Graeme; Danchin, Margaret

    2017-01-01

    ABSTRACT Background: Maternal antibodies, acquired passively via placenta and/or breast milk, may contribute to the reduced efficacy of oral rotavirus vaccines observed in children in developing countries. This study aimed to investigate the effect of rotavirus specific maternal antibodies on the serum IgA response or stool excretion of vaccine virus after any dose of an oral rotavirus vaccine, RV3-BB, in parallel to a Phase IIa clinical trial conducted at Dunedin Hospital, New Zealand. At the time of the study rotavirus vaccines had not been introduced in New Zealand and the burden of rotavirus disease was evident. Methods: Rotavirus specific IgG and serum neutralizing antibody (SNA) levels in cord blood and IgA levels in colostrum and breast milk samples collected ∼4 weeks, ∼20 weeks and ∼28 weeks after birth were measured. Infants were randomized to receive the first dose of vaccine at 0–5 d (neonatal schedule) or 8 weeks (infant schedule). Breast feeding was with-held for 30 minutes before and after vaccine administration. The relationship between rotavirus specific IgG and SNA levels in cord blood and IgA in colostrum and breast milk at the time of first active dose of RV3-BB vaccine and level of IgA response and stool excretion after 3 doses of vaccine was assessed using linear and logistic regression. Results: Forty infants received 3 doses of RV3-BB rotavirus vaccine and were included in the analysis of the neonatal and infant groups. Rotavirus specific IgA in colostrum (neonatal schedule group) and breast milk at 4 weeks (infant schedule group) was identified in 14/21 (67%) and 14/17 (82%) of infants respectively. There was little evidence of an association between IgA in colostrum or breast milk IgA at 4 weeks, or between cord IgG or SNA level, and IgA response or stool excretion after 3 doses of RV3-BB, or after one dose (neonatal schedule) (all p>0.05). Conclusions: The level of IgA in colostrum or breast milk and level of placental Ig

  12. Rotavirus specific maternal antibodies and immune response to RV3-BB neonatal rotavirus vaccine in New Zealand.

    Science.gov (United States)

    Chen, Mee-Yew; Kirkwood, Carl D; Bines, Julie; Cowley, Daniel; Pavlic, Daniel; Lee, Katherine J; Orsini, Francesca; Watts, Emma; Barnes, Graeme; Danchin, Margaret

    2017-05-04

    Maternal antibodies, acquired passively via placenta and/or breast milk, may contribute to the reduced efficacy of oral rotavirus vaccines observed in children in developing countries. This study aimed to investigate the effect of rotavirus specific maternal antibodies on the serum IgA response or stool excretion of vaccine virus after any dose of an oral rotavirus vaccine, RV3-BB, in parallel to a Phase IIa clinical trial conducted at Dunedin Hospital, New Zealand. At the time of the study rotavirus vaccines had not been introduced in New Zealand and the burden of rotavirus disease was evident. Rotavirus specific IgG and serum neutralizing antibody (SNA) levels in cord blood and IgA levels in colostrum and breast milk samples collected ∼4 weeks, ∼20 weeks and ∼28 weeks after birth were measured. Infants were randomized to receive the first dose of vaccine at 0-5 d (neonatal schedule) or 8 weeks (infant schedule). Breast feeding was with-held for 30 minutes before and after vaccine administration. The relationship between rotavirus specific IgG and SNA levels in cord blood and IgA in colostrum and breast milk at the time of first active dose of RV3-BB vaccine and level of IgA response and stool excretion after 3 doses of vaccine was assessed using linear and logistic regression. Forty infants received 3 doses of RV3-BB rotavirus vaccine and were included in the analysis of the neonatal and infant groups. Rotavirus specific IgA in colostrum (neonatal schedule group) and breast milk at 4 weeks (infant schedule group) was identified in 14/21 (67%) and 14/17 (82%) of infants respectively. There was little evidence of an association between IgA in colostrum or breast milk IgA at 4 weeks, or between cord IgG or SNA level, and IgA response or stool excretion after 3 doses of RV3-BB, or after one dose (neonatal schedule) (all p>0.05). The level of IgA in colostrum or breast milk and level of placental IgG and SNA did not impact on the serum IgA response or

  13. Numerical analysis of drilling hole work-hardening effects in hole-drilling residual stress measurement

    Science.gov (United States)

    Li, H.; Liu, Y. H.

    2008-11-01

    The hole-drilling strain gage method is an effective semi-destructive technique for determining residual stresses in the component. As a mechanical technique, a work-hardening layer will be formed on the surface of the hole after drilling, and affect the strain relaxation. By increasing Young's modulus of the material near the hole, the work-hardening layer is simplified as a heterogeneous annulus. As an example, two finite rectangular plates submitted to different initial stresses are treated, and the relieved strains are measured by finite element simulation. The accuracy of the measurement is estimated by comparing the simulated residual stresses with the given initial ones. The results are shown for various hardness of work-hardening layer. The influence of the relative position of the gages compared with the thickness of the work-hardening layer, and the effect of the ratio of hole diameter to work-hardening layer thickness are analyzed as well.

  14. Radiation hardening of oxygen-doped niobium by 14-MeV neutrons

    International Nuclear Information System (INIS)

    Bradley, E.R.; Jones, R.H.

    1983-09-01

    The flow properties of niobium containing 185 and 480 wt ppM oxygen have been studied following irradiation at 300K with T(d,n) neutrons to fluence levels ranging from 6 x 10 20 to 2 x 10 22 m -2 . Two hardening stages connected by a plateau region were observed in the niobium containing 185 wt ppM oxygen. Increasing the oxygen content by 300 wt ppM oxygen shifted the beginning of the high-fluence hardening stage from 6 x 10 21 to 1 x 10 21 m -2 , thereby eliminating the plateau region. This shift resulted in 1.5 times more hardening in the oxygen-doped niobium irradiated to fluence levels above 5 x 10 21 m -2

  15. A COTS-based single board radiation-hardened computer for space applications

    International Nuclear Information System (INIS)

    Stewart, S.; Hillman, R.; Layton, P.; Krawzsenek, D.

    1999-01-01

    There is great community interest in the ability to use COTS (Commercial-Off-The-Shelf) technology in radiation environments. Space Electronics, Inc. has developed a high performance COTS-based radiation hardened computer. COTS approaches were selected for both hardware and software. Through parts testing, selection and packaging, all requirements have been met without parts or process development. Reliability, total ionizing dose and single event performance are attractive. The characteristics, performance and radiation resistance of the single board computer will be presented. (authors)

  16. Residual stress analysis of drive shafts after induction hardening

    Energy Technology Data Exchange (ETDEWEB)

    Lemos, Guilherme Vieira Braga; Rocha, Alexandre da Silva; Nunes, Rafael Menezes, E-mail: lemos_gl@yahoo.com.br [Universidade Federal do Rio Grande do Sul (UFRS), Porto Algre, RS (Brazil); Hirsch, Thomas Karl [Stiftung Institut für Werkstofftechnik (IWT), Bremen (Germany)

    2014-08-15

    Typically, for automotive shafts, shape distortion manifests itself in most cases after the induction hardening by an effect known as bending. The distortion results in a boost of costs, especially due to machining parts in the hardened state to fabricate its final tolerances. In the present study, residual stress measurements were carried out on automotive drive shafts made of DIN 38B3 steel. The samples were selected in consequence of their different distortion properties by an industrial manufacturing line. One tested shaft was straightened, because of the considerable dimensional variation and the other one not. Firstly, the residual stress measurements were carried out by using a portable diffractometer, in order to avoid cutting the shafts and evaluate the original state of the stresses, and afterwards a more detailed analysis was realized by a conventional stationary diffractometer. The obtained results presented an overview of the surface residual stress profiles after induction hardening and displayed the influence of the straightening process on the redistribution of residual stresses. They also indicated that the effects of the straightening in the residual stresses cannot be neglected. (author)

  17. Allergic contact dermatitis from resin hardeners during the manufacture of thermosetting coating paints.

    Science.gov (United States)

    Foulds, I S; Koh, D

    1992-02-01

    5 production operators from 2 factories manufacturing thermosetting coating paint developed work-related skin disorders within 12 months of the introduction of a new powdered paint product. All 5 workers were found to have allergic contact dermatitis from 2 epoxy resin hardeners, both of which were commercial preparations of triglycidyl isocyanurate (TGIC). 2 of the workers had concomitant sensitization to epoxy resin in the standard series and several of the epoxy resin preparations at the workplace. TGIC has been reported as a contact sensitizer both in persons producing the chemical and among end-users of TGIC-containing products. These 5 reported cases document allergic contact dermatitis from commercial TGIC among exposed workers during an intermediate process of powdered paint manufacture. The possibility of substituting this epoxy resin hardener with less sensitizing alternatives should be explored.

  18. Susceptibility and hardening of electronic systems to fast transient threats: new challenges ahead

    Directory of Open Access Journals (Sweden)

    F. Sabath

    2004-01-01

    Full Text Available The field of susceptibility and hardening of electronic systems to transient threats has experienced a significant growth during the past ten years. Driven by the development in the area of non-lethal electromagnetic weapons it has become necessary to extend the classical set of transient threats, consisting of LEMP, ESD and NEMP, by a fast transient threat with an extreme bandwidth. The investigation of the susceptibility to those UWB threats, characterized by a bandwidth of more than a quarter of the center frequency, rise times of less than 200 ps and pulse durations in the ns regime, is of special interest. This paper presents an overview of current challenges of the hardening against UWB threats. It discusses recent research trends in transient susceptibility measurements, protection concepts and methods of analysis.

  19. Crystal Structure of Mycobacterium tuberculosis H37Rv AldR (Rv2779c), a Regulator of the ald Gene: DNA BINDING AND IDENTIFICATION OF SMALL MOLECULE INHIBITORS.

    Science.gov (United States)

    Dey, Abhishek; Shree, Sonal; Pandey, Sarvesh Kumar; Tripathi, Rama Pati; Ramachandran, Ravishankar

    2016-06-03

    Here we report the crystal structure of M. tuberculosis AldR (Rv2779c) showing that the N-terminal DNA-binding domains are swapped, forming a dimer, and four dimers are assembled into an octamer through crystal symmetry. The C-terminal domain is involved in oligomeric interactions that stabilize the oligomer, and it contains the effector-binding sites. The latter sites are 30-60% larger compared with homologs like MtbFFRP (Rv3291c) and can consequently accommodate larger molecules. MtbAldR binds to the region upstream to the ald gene that is highly up-regulated in nutrient-starved tuberculosis models and codes for l-alanine dehydrogenase (MtbAld; Rv2780). Further, the MtbAldR-DNA complex is inhibited upon binding of Ala, Tyr, Trp and Asp to the protein. Studies involving a ligand-binding site G131T mutant show that the mutant forms a DNA complex that cannot be inhibited by adding the amino acids. Comparative studies suggest that binding of the amino acids changes the relative spatial disposition of the DNA-binding domains and thereby disrupt the protein-DNA complex. Finally, we identified small molecules, including a tetrahydroquinoline carbonitrile derivative (S010-0261), that inhibit the MtbAldR-DNA complex. The latter molecules represent the very first inhibitors of a feast/famine regulatory protein from any source and set the stage for exploring MtbAldR as a potential anti-tuberculosis target. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  20. a Calorimetric Study of the Precipitation Hardening Mechanisms in AN Al-Cu-Mg-Si Alloy

    Science.gov (United States)

    Hayoune, Abdelali

    2013-08-01

    The precipitation phenomena and the related hardening in an Al-Cu-Mg-Si alloy were studied by calorimetry, X-ray diffraction analysis and microhardness measurements. The main calorimetric peaks were identified to be due to β‧‧, θ‧ and Q‧ phases precipitation. The hardening during aging at room temperature and 160°C, was respectively, explained by atomic clusters and GP zones formation and by GP zones and β‧‧/θ‧ phases coprecipitation. Although the mechanical properties variation during aging at 200°C is simple, the corresponding microstructural evolution is complex: on the basis of the DSC results, the increasing of microhardness values, is mainly due to the coprecipitation of GP zones and β‧‧/θ‧ phases, however, the maximum hardening is explained by the coexistence of β‧‧/θ‧ and θ‧‧ phases. Another important conclusion is that during aging at 160°C and 200°C, the θ‧ phase is essentially developed from GP zones.

  1. BUSFET - A Novel Radiation-Hardened SOI Transistor

    International Nuclear Information System (INIS)

    Dodd, P.E.; Draper, B.L.; Schwank, J.R.; Shaneyfelt, M.R.

    1999-01-01

    A partially-depleted SOI transistor structure has been designed that does not require the use of specially-processed hardened buried oxides for total-dose hardness and maintains the intrinsic SEU and dose rate hardness advantages of SOI technology

  2. Hardening in AlN induced by point defects

    International Nuclear Information System (INIS)

    Suematsu, H.; Mitchell, T.E.; Iseki, T.; Yano, T.

    1991-01-01

    Pressureless-sintered AIN was neutron irradiated and the hardness change was examined by Vickers indentation. The hardness was increased by irradiation. When the samples were annealed at high temperature, the hardness gradually decreased. Length was also found to increase and to change in the same way as the hardness. A considerable density of dislocation loops still remained, even after the hardness completely recovered to the value of the unirradiated sample. Thus, it is concluded that the hardening in AIN is caused by isolated point defects and small clusters of point defects, rather than by dislocation loops. Hardness was found to increase in proportion to the length change. If the length change is assumed to be proportional to the point defect density, then the curve could be fitted qualitatively to that predicted by models of solution hardening in metals. Furthermore, the curves for three samples irradiated at different temperatures and fluences are identical. There should be different kinds of defect clusters in samples irradiated at different conditions, e.g., the fraction of single point defects is the highest in the sample irradiated at the lowest temperature. Thus, hardening is insensitive to the kind of defects remaining in the sample and is influenced only by those which contribute to length change

  3. ON THE SPECTRAL HARDENING AT ∼>300 keV IN SOLAR FLARES

    International Nuclear Information System (INIS)

    Li, G.; Kong, X.; Zank, G.; Chen, Y.

    2013-01-01

    It has long been noted that the spectra of observed continuum emissions in many solar flares are consistent with double power laws with a hardening at energies ∼>300 keV. It is now widely believed that at least in electron-dominated events, the hardening in the photon spectrum reflects an intrinsic hardening in the source electron spectrum. In this paper, we point out that a power-law spectrum of electrons with a hardening at high energies can be explained by the diffusive shock acceleration of electrons at a termination shock with a finite width. Our suggestion is based on an early analytical work by Drury et al., where the steady-state transport equation at a shock with a tanh profile was solved for a p-independent diffusion coefficient. Numerical simulations with a p-dependent diffusion coefficient show hardenings in the accelerated electron spectrum that are comparable with observations. One necessary condition for our proposed scenario to work is that high-energy electrons resonate with the inertial range of the MHD turbulence and low-energy electrons resonate with the dissipation range of the MHD turbulence at the acceleration site, and the spectrum of the dissipation range ∼k –2.7 . A ∼k –2.7 dissipation range spectrum is consistent with recent solar wind observations.

  4. Why semiconductors must be hardened when used in space

    International Nuclear Information System (INIS)

    Winokur, P.S.

    2000-01-01

    The natural space radiation environment presents a great challenge to present and future satellite systems with significant assets in space. Defining requirements for such systems demands knowledge about the space radiation environment and its effects on electronics and optoelectronics technologies, as well as suitable risk assessment of the uncertainties involved. For mission of high radiation levels, radiation-hardened integrated circuits will be required to preform critical mission functions. The most successful systems in space will be those that are best able to blend standard commercial electronics with custom radiation-hardened electronics in a mix that is suitable for the system of interest

  5. Dosimetry using Gafchromic XR-RV2 radiochromic films in interventional radiology

    International Nuclear Information System (INIS)

    Neocleous, A.; Yakoumakis, E.; Gialousis, G.; Dimitriadis, A.; Yakoumakis, N.; Georgiou, E.

    2011-01-01

    Patient dose measurements of local entrance dose to the skin have been carried out using radiochromic film (Gafchromic XR-RV2) in a sample of interventional procedures. The major aim of the work was to measure patient entrance dose from such examinations using Gafchromic XR-RV2. Forty-five various interventional procedures (including nephrostomies and urinary stenting, biliary stenting and percutaneous transhepatic biliary drainage (PTBD) and aorta stent grafting) were evaluated. Maximum entrance doses were 537±119 mGy in nephrostomies, 943±631 mGy in biliary stenting and PTBD and 2425±569 mGy in aorta stent grafting. Results indicate that all patients undergoing aorta stent grafting received skin dose above 1500 mGy, which means that there is an increasing potential to suffer radiation-induced skin injuries. The film provides dose mapping, the position of the skin area with highest dose and can be used for immediate qualitative and as well as for quantitative assessment of patient skin dose. (authors)

  6. Ferrous arrowheads and their oil quench hardening: Some early Indian evidence

    Science.gov (United States)

    Dube, R. K.

    2008-05-01

    A wide variety of ferrous arrowheads were in use in ancient India. Several typical chemical analyses of arrowheads found from archaeological excavation carried out at Kaushambi are reported in this paper. The average carbon content of these arrowheads varied from as low as 0.1 wt.% to approximately 0.9 wt.%. Literary evidence for oil quench hardening of ferrous arrowheads, as reported in famous Sanskrit epics—the Rāmāyana and the Mahābhārata—have been discussed in this paper. This type of quench hardening was intentionally adopted as it helped in preventing distortion and formation of quench cracks in arrowheads. The oil quench-hardened arrowheads were rubbed on stones to sharpen them, which also brought about tempering of martensite due to frictional heat.

  7. Strain hardening behavior and microstructural evolution during plastic deformation of dual phase, non-grain oriented electrical and AISI 304 steels

    Energy Technology Data Exchange (ETDEWEB)

    Soares, Guilherme Corrêa; Gonzalez, Berenice Mendonça; Arruda Santos, Leandro de, E-mail: leandro.arruda@demet.ufmg.br

    2017-01-27

    Strain hardening behavior and microstructural evolution of non-grain oriented electrical, dual phase, and AISI 304 steels, subjected to uniaxial tensile tests, were investigated in this study. Tensile tests were performed at room temperature and the strain hardening behavior of the steels was characterized by three different parameters: modified Crussard–Jaoul stages, strain hardening rate and instantaneous strain hardening exponent. Optical microscopic analysis, X-ray diffraction measurements, phase quantification by Rietveld refinement and hardness tests were also carried out in order to correlate the microstructural and mechanical responses to plastic deformation. Distinct strain hardening stages were observed in the steels in terms of the instantaneous strain hardening exponent and the strain hardening rate. The dual phase and non-grain oriented steels exhibited a two-stage strain hardening behavior while the AISI 304 steel displayed multiple stages, resulting in a more complex strain hardening behavior. The dual phase steels showed a high work hardening capacity in stage 1, which was gradually reduced in stage 2. On the other hand, the AISI 304 steel showed high strain hardening capacity, which continued to increase up to the tensile strength. This is a consequence of its additional strain hardening mechanism, based on a strain-induced martensitic transformation, as shown by the X-ray diffraction and optical microscopic analyses.

  8. Study of a design criterion for 316L irradiated represented by a strain hardened material

    International Nuclear Information System (INIS)

    Gouin, H.

    1999-01-01

    The aim of this study is to analyse the consequence of radiation on different structure submitted to imposed displacement loading and for damages due to plastic instability or rupture. The main consequence of radiation is a material hardening with a ductility decrease. This effect is similar to initial mechanical hardening: the mechanical properties (determined on smooth tensile specimen) evolve in the same way while irradiation or mechanical hardening increase. So in this study, radiation hardening is simulated by mechanical hardening (swaging). Tests were carried out for which two damages were considered: plastic instability and rupture. These two damages were studied with initial mechanical hardening (5 tested hammering rate 0, 15, 25, 35 and 45% on 316L stainless steel). Likewise two types of loading were studied: tensile or bending loading on specimens with or without geometrical singularities (notches). From tensile tests, two deformation criteria are proposed for prevention against the two quoted damages. Numerical study is carried out allowing to confirm hypothesis made at the time of the tensile test result interpretation and to validate the rupture criterion by applying on bending test. (author)

  9. Method of case hardening depth testing by using multifunctional ultrasonic testing instrument

    International Nuclear Information System (INIS)

    Salchak, Y A; Sednev, D A; Ardashkin, I B; Kroening, M

    2015-01-01

    The paper describes usability of ultrasonic case hardening depth control applying standard instrument of ultrasonic inspections. The ultrasonic method of measuring the depth of the hardened layer is proposed. Experimental series within the specified and multifunctional ultrasonic equipment are performed. The obtained results are compared with the results of a referent method of analysis. (paper)

  10. Effect of pre-hardening on the lifetime of type 304L austenitic stainless steels

    International Nuclear Information System (INIS)

    Kpodekon, C.

    2010-01-01

    This study deals with the effect of the loading history on the cyclic behavior and the fatigue life of two kinds (THYSSEN and CLI) of 304L stainless steel at room temperature. The experiments have been performed using two specimens' categories. The first one (virgin) has been submitted to only classical fatigue tests while in the second category, prior to the fatigue test, the specimen is subjected to a pre-hardening process under either monotonic or cyclic strain control. Cyclic softening followed by cyclic hardening are observed for the virgin specimens while only cyclic softening is exhibited by the pre-hardened specimens. The obtained results show that fatigue life is strongly influenced by the pre-hardening: it seems beneficial under stress control but detrimental under strain control, even in the presence of a compressive mean stress. The results are discussed regarding the cyclic evolution of the elastic modulus as well as the isotropic and kinematic parts of the strain hardening, and strain energy density per cycle, in different configurations: with or without prehardening,stress or strain control. (author)

  11. Effect of Annealing on Microstructures and Hardening of Helium-Hydrogen-Implanted Sequentially Vanadium Alloys

    Science.gov (United States)

    Jiang, Shaoning; Wang, Zhiming

    2018-03-01

    The effect of post-irradiation annealing on the microstructures and mechanical properties of V-4Cr-4Ti alloys was studied. Helium-hydrogen-irradiated sequentially V-4Cr-4Ti alloys at room temperature (RT) were undergone post-irradiation annealing at 450 °C over periods of up to 30 h. These samples were carried out by high-resolution transmission electron microscopy (HRTEM) observation and nanoindentation test. With the holding time, large amounts of point defects produced during irradiation at RT accumulated into large dislocation loops and then dislocation nets which promoted the irradiation hardening. Meanwhile, bubbles appeared. As annealing time extended, these bubbles grew up and merged, and finally broke up. In the process, the size of bubbles increased and the number density decreased. Microstructural changes due to post-irradiation annealing corresponded to the change of hardening. Dislocations and bubbles are co-contributed to irradiation hardening. With the holding time up to 30 h, the recovery of hardening is not obvious. The phenomenon was discussed by dispersed barrier hardening model and Friedel-Kroupa-Hirsch relationship.

  12. Comparison of hardenability calculation methods of the heat-treatable constructional steels

    Energy Technology Data Exchange (ETDEWEB)

    Dobrzanski, L.A.; Sitek, W. [Division of Tool Materials and Computer Techniques in Metal Science, Silesian Technical University, Gliwice (Poland)

    1995-12-31

    Evaluation has been made of the consistency of calculation of the hardenability curves of the selected heat-treatable alloyed constructional steels with the experimental data. The study has been conducted basing on the analysis of present state of knowledge on hardenability calculation employing the neural network methods. Several calculation examples and comparison of the consistency of calculation methods employed are included. (author). 35 refs, 2 figs, 3 tabs.

  13. BUSFET -- A radiation-hardened SOI transistor

    International Nuclear Information System (INIS)

    Schwank, J.R.; Shaneyfelt, M.R.; Draper, B.L.; Dodd, P.E.

    1999-01-01

    The total-dose hardness of SOI technology is limited by radiation-induced charge trapping in gate, field, and SOI buried oxides. Charge trapping in the buried oxide can lead to back-channel leakage and makes hardening SOI transistors more challenging than hardening bulk-silicon transistors. Two avenues for hardening the back-channel are (1) to use specially prepared SOI buried oxides that reduce the net amount of trapped positive charge or (2) to design transistors that are less sensitive to the effects of trapped charge in the buried oxide. In this work, the authors propose a partially-depleted SOI transistor structure for mitigating the effects of trapped charge in the buried oxide on radiation hardness. They call this structure the BUSFET--Body Under Source FET. The BUSFET utilizes a shallow source and a deep drain. As a result, the silicon depletion region at the back channel caused by radiation-induced charge trapping in the buried oxide does not form a conducting path between source and drain. Thus, the BUSFET structure design can significantly reduce radiation-induced back-channel leakage without using specially prepared buried oxides. Total dose hardness is achieved without degrading the intrinsic SEU or dose rate hardness of SOI technology. The effectiveness of the BUSFET structure for reducing total-dose back-channel leakage depends on several variables, including the top silicon film thickness and doping concentration, and the depth of the source. 3-D simulations show that for a body doping concentration of 10 18 cm -3 , a drain bias of 3 V, and a source depth of 90 nm, a silicon film thickness of 180 nm is sufficient to almost completely eliminate radiation-induced back-channel leakage. However, for a doping concentration of 3 x 10 17 cm -3 , a thicker silicon film (300 nm) must be used

  14. Strain hardening by dynamic slip band refinement in a high-Mn lightweight steel

    International Nuclear Information System (INIS)

    Welsch, E.; Ponge, D.; Hafez Haghighat, S.M.; Sandlöbes, S.; Choi, P.; Herbig, M.; Zaefferer, S.; Raabe, D.

    2016-01-01

    The strain hardening mechanism of a high-Mn lightweight steel (Fe-30.4Mn-8Al-1.2C (wt%)) is investigated by electron channeling contrast imaging (ECCI) and transmission electron microscopy (TEM). The alloy is characterized by a constant high strain hardening rate accompanied by high strength and high ductility (ultimate tensile strength: 900 MPa, elongation to fracture: 68%). Deformation microstructures at different strain levels are studied in order to reveal and quantify the governing structural parameters at micro- and nanometer scales. As the material deforms mainly by planar dislocation slip causing the formation of slip bands, we quantitatively study the evolution of the slip band spacing during straining. The flow stress is calculated from the slip band spacing on the basis of the passing stress. The good agreement between the calculated values and the tensile test data shows dynamic slip band refinement as the main strain hardening mechanism, enabling the excellent mechanical properties. This novel strain hardening mechanism is based on the passing stress acting between co-planar slip bands in contrast to earlier attempts to explain the strain hardening in high-Mn lightweight steels that are based on grain subdivision by microbands. We discuss in detail the formation of the finely distributed slip bands and the gradual reduction of the spacing between them, leading to constantly high strain hardening. TEM investigations of the precipitation state in the as-quenched state show finely dispersed atomically ordered clusters (size < 2 nm). The influence of these zones on planar slip is discussed.

  15. Human neonatal rotavirus vaccine (RV3-BB) targets rotavirus from birth

    Science.gov (United States)

    Thobari, Jarir At; Satria, Cahya Dewi; Handley, Amanda; Watts, Emma; Cowley, Daniel; Nirwati, Hera; Ackland, James; Standish, Jane; Justice, Frances; Byars, Gabrielle; Lee, Katherine J.; Barnes, Graeme L.; Bachtiar, Novilia S.; Icanervilia, Ajeng Viska; Boniface, Karen; Bogdanovic-Sakran, Nada; Pavlic, Daniel; Bishop, Ruth F.; Kirkwood, Carl D.; Buttery, Jim P.; Soenarto, Yati

    2018-01-01

    Background A birth dose strategy using a neonatal rotavirus vaccine to target early prevention of rotavirus disease may address remaining barriers to global vaccine implementation. Methods We conducted a randomized, placebo-controlled trial in Indonesia to evaluate the efficacy of an oral human neonatal rotavirus vaccine (RV3-BB) to prevent rotavirus gastroenteritis. Healthy newborns received three doses of RV3-BB administered in a neonatal schedule at 0-5 days, 8 and 14 weeks or infant schedule at 8, 14 and 18 weeks, or placebo. Laboratory-confirmed rotavirus gastroenteritis was graded using a modified Vesikari score. The primary analysis was efficacy against severe rotavirus gastroenteritis from two weeks after all doses to 18 months in the combined vaccine group (neonatal and infant schedule) compared with placebo. Results Vaccine efficacy against severe rotavirus gastroenteritis to 18 months was 63% in the combined vaccine group (95% CI 34, 80; p<0.001), 75% in the neonatal vaccine group (95% confidence interval [CI] 44, 91; p<0.001) and 51% in the infant vaccine group (95% CI 7, 76; p=0.03) in the per protocol analysis, with similar results in the intention-to-treat analysis. Vaccine efficacy to 12 months was 94% in the neonatal vaccine group (95%CI 56, 99; p=0.006). Vaccine take occurred in 78/83 (94%) in the neonatal vaccine group and 83/84 (99%) in the infant vaccine group. The vaccine was well tolerated, with similar incidence of adverse events in vaccine and placebo recipients. Conclusion RV3-BB was efficacious, immunogenic and well-tolerated when administered in a neonatal or infant schedule in Indonesia. PMID:29466164

  16. Coatings hardenable by ionizing radiation and their applications

    International Nuclear Information System (INIS)

    Aronoff, E.J.; Labana, S.S.

    1976-01-01

    The invention deals with the production of a coating medium which can be hardened by ionizing radiation. The composition includes tetravinyl compounds containing no free hydroxyl groups which were obtained by the conversion of di-epoxides with acryl or methacryl acid via the intermediary step of a divinyl ester condensation product. The intermediary product is converted with acryloyl or methacryloyl halides. The mass still contains non-polymerisable solvent (such as tolual, xylol), pigments and fillers. It is of advantage if the di-epoxide has a molecular weight of 140 to 500. Furthermore, coatings are to be made of this coating medium which are hardened by ionizing radiation at temperatures between 20 0 C and 70 0 C. 19 examples. (HK) [de

  17. An outbreak of contact dermatitis from toluenesulfonamide formaldehyde resin in a nail hardener

    NARCIS (Netherlands)

    de Wit, F. S.; de Groot, A. C.; Weyland, J. W.; Bos, J. D.

    1988-01-01

    8 cases of contact dermatitis from toluenesulfonamide formaldehyde resin in a nail hardener are presented. Most patients had used nail lacquers containing this resin for many years without trouble, but became sensitized to the resin shortly after the introduction of this particular nail hardener. A

  18. Nonlinear response to the multiple sine wave excitation of a softening--hardening system

    International Nuclear Information System (INIS)

    Koplik, B.; Subudhi, M.; Curreri, J.

    1979-01-01

    In studying the earthquake response of the HTGR core, it was observed that the system can display softening--hardening characteristics. This is of great consequence in evaluating the structural safety aspects of the core. In order to obtain a better understanding of the governing parameters, an investigation was undertaken with a single-degree-of-freedom system having a softening--hardening spring characteristic and excited by multiple sine waves. A parametric study varying the input amplitudes and the spring characteristic was performed. Transients were introduced into the system, and the jump phenomena between the lower softening characteristics to the higher hardening curve was studied

  19. Deep Drawing Simulation Of High And Ultrahigh Strength Steels Under Consideration Of Anisotropic Hardening

    International Nuclear Information System (INIS)

    Roll, Karl; Faust, Alexander; Kessler, Lutz

    2007-01-01

    In today's sheet metal forming simulation, most attention is paid to yield loci functions, which describe the anisotropy of the material in yielding. The coefficients, defining the shape of the yield locus in these functions are usually fitted at a certain level of plastic work and are then valid for the whole range of plastic deformation. Modern high and ultrahigh strength steels, especially those with induced plasticity, may often exhibit only a very small anisotropy in yielding, but a severe anisotropy in work hardening for different loading conditions. This behavior can not be described by fitting the yield locus at a specific value of plastic deformation. An approach to take into account the anisotropic hardening of sheet metals is to provide different yield curves for several loading conditions and expand the yield locus dependent on the current form of load. By doing this, one can use a comparatively simple yield locus, like that of Hill from 1948, because all anisotropy is given by the different hardening curves. For the commercial FEM code LS DYNA the material model MATFEM Generalized Yield is available as a user subroutine, which supports this approach. In this paper, forming simulation results of different yield loci are compared with experimental results. The simulations were carried out in LS-DYNA with the Barlat 89 and 2000 yield loci and isotropic hardening and with the GenYld model combining a Hill 48 yield locus and anisotropic hardening. The deep drawing experiments were conducted on a hydraulic press, measuring binder and punch forces. The deformation of the sheet was measured by optical grid analysis. A comparison of the simulated and measured plastic strains shows that using a model including anisotropic hardening can produce better results than the usage of a complex yield locus but isotropic hardening for the examined materials. This might be interesting for e.g. spring back simulations. By combining a simple yield locus with anisotropic

  20. Overview of errors in the reference sequence and annotation of Mycobacterium tuberculosis H37Rv, and variation amongst its isolates

    KAUST Repository

    Köser, Claudio U.

    2012-06-01

    Since its publication in 1998, the genome sequence of the Mycobacterium tuberculosis H37Rv laboratory strain has acted as the cornerstone for the study of tuberculosis. In this review we address some of the practical aspects that have come to light relating to the use of H37Rv throughout the past decade which are of relevance for the ongoing genomic and laboratory studies of this pathogen. These include errors in the genome reference sequence and its annotation, as well as the recently detected variation amongst isolates of H37Rv from different laboratories. © 2011 Elsevier B.V..

  1. Surface Induction Hardening of Axi-Symmetric Bodies

    Czech Academy of Sciences Publication Activity Database

    Barglik, J.; Doležel, Ivo; Škopek, M.; Ulrych, B.

    2001-01-01

    Roč. 1, č. 1 (2001), s. 11-16 ISSN 1335-8243 R&D Projects: GA ČR GA102/01/0184 Grant - others:-(PL) 7T08603716 Keywords : induction heating * induction hardening * numerical solution Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

  2. The effect of austenitizing conditions in the ductile iron hardening process on longitudinal ultrasonic wave velocity

    Directory of Open Access Journals (Sweden)

    A. W. Orłowicz

    2014-04-01

    Full Text Available The paper presents results of a research on the effect of austenitizing temperature and time adopted in the hardening operation on the ultrasonic wave velocity in ductile iron. It has been found that with increasing austenitizing temperature and with the passage of the austenitizing time, a monotonic decrease of the ultrasonic longitudinal wave velocity value occurred. Implementation of ultrasonic testing of results obtained in the course of the cast iron hardening process both in production and as-cast conditions, requires development of a test methodology that must take into account the influence of base material structure (degree of nodularization, graphite precipitation count on the ultrasound wave velocity.

  3. SDSS-III MARVELS Planet Candidate RV Follow-up

    Science.gov (United States)

    Ge, Jian; Thomas, Neil; Ma, Bo; Li, Rui; SIthajan, Sirinrat

    2014-02-01

    Planetary systems, discovered by the radial velocity (RV) surveys, reveal strong correlations between the planet frequency and stellar properties, such as metallicity and mass, and a greater diversity in planets than found in the solar system. However, due to the sample sizes of extant surveys (~100 to a few hundreds of stars) and their heterogeneity, many key questions remained to be addressed: Do metal poor stars obey the same trends for planet occurrence as metal rich stars? What is the distribution of giant planets around intermediate- mass stars and binaries? Is the ``planet desert'' within 0.6 AU in the planet orbital distribution of intermediate-mass stars real? The MARVELS survey has produced the largest homogeneous RV measurements of 3300 V=7.6-12 FGK stars. The latest data pipeline effort at UF has been able to remove long term systematic errors suffered in the earlier data pipeline. 18 high confident giant planet candidates have been identified among newly processed data. We propose to follow up these giant planet candidates with the KPNO EXPERT instrument to confirm the detection and also characterize their orbits. The confirmed planets will be used to measure occurrence rates, distributions and multiplicity of giants planets around F,G,K stars with a broad range of mass (~0.6-2.5 M_⊙) and metallicity ([Fe/H]~-1.5-0.5). The well defined MARVELS survey cadence allows robust determinations of completeness limits for rigorously testing giant planet formation theories and constraining models.

  4. Hardening mechanism of an Ag-Pd-Cu-Au dental casting alloy

    International Nuclear Information System (INIS)

    Seol, Hyo-Joung; Kim, Gi-Chul; Son, Kuk-Hyeon; Kwon, Yong Hoon; Kim, Hyung-Il

    2005-01-01

    Age-hardening behaviour and the related microstructural changes were studied to elucidate the hardening mechanism of an Ag-Pd-Cu-Au dental casting alloy by means of hardness test, X-ray diffraction (XRD), scanning electron microscopic (SEM) observations and electron probe microanalysis (EPMA). By considering hardness test and XRD results together, it was revealed that the hardness increased during the early stage of phase transformation of α into α 1 . In the SEM photographs, two phases of matrix and particle-like structures were observed, and the precipitation of element from the matrix progressed during isothermal aging. By SEM observations and EPMA analysis, it could be supposed that the increase in hardness was caused by the diffusion and aggregation of Cu atoms from the Ag-rich α matrix containing Au and Cu in the early stage of age-hardening process, and that the decrease in hardness was caused by the progress of coarsening of Cu-rich lamellar precipitates in the later stage of the age-hardening process. The changes in the Ag-rich matrix caused both the increase and decrease in hardness, and the CuPd phase containing small amounts of Zn and Sn did not contribute to the hardness changes

  5. EFFECT OF STRAIN HARDENING ON FATIGUE CRACK CLOSURE IN ALUMINUM ALLOY UNDER CONSTANT AMPLITUDE WITH SINGLE OVERLOAD

    Directory of Open Access Journals (Sweden)

    Nirpesh Vikram

    2015-12-01

    Full Text Available In this study effect of strain hardening on crack closure has been examined with the help of experiments and finite element method on the side edge notched specimen of five different Aluminum alloy (3003 Al, 5052 Al, 6061 T6, 6063 T6, 6351 in mode I under constant amplitude fatigue loading with single overload using Abaqus® 6.10 which is very well accepted FEM application in research. Extended Finite Element Method Module has been used to determine effective stress intensity factor at the crack tip while propagation takes place. FEM results have given good agreement with experimental results. Regression analysis has also been done with SPSS® 16 and dependency of strain hardening coefficient on crack closure has analyzed. A generalized empirical formula has been developed based on strain hardening to calculate effective stress intensity range ratio and a modified Paris law has also been formulated for these aluminum alloy.

  6. Nuclear EMP: key suppression device parameters for EMP hardening

    International Nuclear Information System (INIS)

    Durgin, D.L.; Brown, R.M.

    1975-03-01

    The electrical transients induced by EMP exhibit unique characteristics which differ considerably from transients associated with other phenomena such as lightning, switching, and circuit malfunctions. The suppression techniques developed to handle more common transients, though not necessarily the same devices, can be used for EMP damage protection. The suppression devices used for circuit level EMP protection are referred to as Terminal Protection Devices (TPD). Little detailed data describing the response of TPD's to EMP-related transients have been published. While most vendors publish specifications for TPD performance, there is little standardization of parameters and TPD response models are not available. This lack of parameter standardization has resulted in a proliferation of test data that is sometimes conflicting and often not directly comparable. This paper derives and/or defines a consistent set of parameters based on EMP circuit hardening requirements and on measurable component parameters and is concerned only with use of TPD's to prevent permanent damage. Three sets of parameters pertaining to pertinent TPD functional characteristics were defined as follows: standby parameters, protection parameters, and failure parameters. These parameters are used to evaluate a representative sample of TPD's and the results are presented in matrix form to facilitate the selection of devices for specific hardening problems

  7. Importance of calcium and magnesium in water - water hardening

    Science.gov (United States)

    Barloková, D.; Ilavský, J.; Kapusta, O.; Šimko, V.

    2017-10-01

    Basic information about importance of calcium and magnesium in water, about their properties, effect to human health, problems what can cause under the lower ( 5 mmol/L) concentrations in water supply distribution systems, the most commonly used methods of water hardening are presented. The article contains the water hardening results carried out during the pilot plant experiments in WTP Hriňová and WTP Turček. For water hardening, treated water at the end of the process line, i.e., after coagulation, sedimentation and filtration, saturated with CO2 and filtrated through half-burnt dolomite material (PVD) was used. The results show that the filtration rate is 17.1 m/h in the case of WTP Hriňová and 15.2 m/h in the case of WTP Turček to achieve the recommended concentration of Ca and Mg in the treated water after the addition of CO2 and filtration through PVD. The longer the water contact time with PVD (depending on the CO2 content), the more water is enriched with magnesium, but the calcium concentration has not so much increased.

  8. On the grain boundary hardening in a B-bearing 304 austenitic stainless steel

    International Nuclear Information System (INIS)

    Yao, X.X.

    1999-01-01

    The precipitates, (Cr,Fe) 23 (C,B) 6 carbides and (Cr,Fe) 2 B borides, formed along the grain boundaries in a 304 austenitic stainless steel containing boron of 33 ppm after solution treatment at 1100 C for 1 h followed by isothermal ageing for 0.5 h at temperatures ranging from 750 to 1050 C have been identified. The influence of these precipitates on the grain boundary hardening has been investigated by means of micro-Vickers hardness measurements. It is found that the degree of grain boundary hardening below 900 C decreases, while it increases above 900 C with increasing ageing temperature. The dissolution of (Cr,Fe) 23 (C,B) 6 carbides and the precipitation of (Cr,Fe) 2 B borides are associated with the changes of grain boundary hardening in this B-bearing 304 austenitic stainless steel between 750 and 1100 C. The non-equilibrium boron segregation enhances the grain boundary hardening when the ageing temperature is above 900 C. (orig.)

  9. Plastic limit analysis with non linear kinematic strain hardening for metalworking processes applications

    International Nuclear Information System (INIS)

    Chaaba, Ali; Aboussaleh, Mohamed; Bousshine, Lahbib; Boudaia, El Hassan

    2011-01-01

    Limit analysis approaches are widely used to deal with metalworking processes analysis; however, they are applied only for perfectly plastic materials and recently for isotropic hardening ones excluding any kind of kinematic hardening. In the present work, using Implicit Standard Materials concept, sequential limit analysis approach and the finite element method, our objective consists in extending the limit analysis application for including linear and non linear kinematic strain hardenings. Because this plastic flow rule is non associative, the Implicit Standard Materials concept is adopted as a framework of non standard plasticity modeling. The sequential limit analysis procedure which considers the plastic behavior with non linear kinematic strain hardening as a succession of perfectly plastic behavior with yielding surfaces updated after each sequence of limit analysis and geometry updating is applied. Standard kinematic finite element method together with a regularization approach is used for performing two large compression cases (cold forging) in plane strain and axisymmetric conditions

  10. Study of radiation hardening in reactor pressure vessel steels

    International Nuclear Information System (INIS)

    Nogiwa, Kimihiro; Nishimura, Akihiko

    2008-01-01

    In order to investigate the dependence of hardening on copper precipitate diameter and density, in-situ transmission electron microscopy (TEM) observations during tensile tests of dislocation gliding through copper rich-precipitates in thermally aged and neutron irradiated Fe-Cu alloys were performed. The obstacle strength has been estimated from the critical bow-out angle, φ, of dislocations. The obstacle distance on the dislocation line measured from in-situ TEM observations were compared with number density and diameter measured by 3D-AP (three dimensional atom probe) and TEM observation. A comparison is made between hardening estimation based on the critical bowing angles and those obtained from conventional tensile tests. (author)

  11. Thermal stress ratcheting analysis of a time-hardening structure

    International Nuclear Information System (INIS)

    Hada, Kazuhiko

    1999-01-01

    Thermal stress ratcheting and shakedown is analyzed for a time-hardening structure: the yield stress increases as time goes on under exposure to neutron irradiation or thermal aging. New three modes of ratcheting and shakedown are identified as transition to other deformation modes. Stress regimes and thermal ratchet strains are formulated as a function of time-increasing yield stress. Moreover, a new model of trouble occurrence frequency as a modification to a bath-tube curve is proposed for calculating a time period of a thermal cycle. Application of the proposed formulation tells us a benefit of taking into account the time hardening due to neutron irradiation. (author)

  12. Coefficient of work-hardening in stage-IV

    CSIR Research Space (South Africa)

    Nabarro, FRN

    1994-04-15

    Full Text Available The theory of work hardening in stage IV depends on the relation between the relative misorientation Psi of neighbouring subgrains and the plastic strain gamma (Psi = B gamma exp). The value of the constant B is suggested to be better related...

  13. Influence of anisotropic hardening on longitudinal welding strains and stresses

    International Nuclear Information System (INIS)

    Gatovskij, K.M.; Revutskij, M.N.

    1981-01-01

    The algorithm and program for estimation of longitudinal welding strains and stresses with account of hardening and Bauschinger effect, which expand the possibilities of more complete description of stress change during thermodeformation welding cycles at bead surfacing on plate made of the 06Kh18N9T steel and AMg61 alloy. It is shown that for metals, deformation curves which are characterized by considerable yield moduli (Esub(T)/E>=0.05) hardening effect is considerable and its account leads to the decrease of stress level in the heataffected zone (down to 20%) [ru

  14. Radiation-hardened microwave communications system

    International Nuclear Information System (INIS)

    Smith, S.F.; Crutcher, R.I.; Vandermolen, R.I.

    1990-01-01

    The consolidated fuel reprocessing program (CFRP) at the Oak Ridge National Laboratory (ORNL) has been developing signal transmission techniques and equipment to improve the efficiency of remote handling operations for nuclear applications. These efforts have been largely directed toward the goals of (a) remotely controlling bilateral force-reflecting servomanipulators for dexterous manipulation-based operations in remote maintenance tasks and (b) providing television viewing of the work site. In September 1987, developmental microwave transceiving hardware operating with dish antennas was demonstrated in the advanced integrated maintenance system (AIMS) facility at ORNL, successfully implementing both high-quality one-way television transmissions and simultaneous bidirectional digital control data transmissions with very low error rates. Initial test results based on digital transmission at a 1.0-Mbaud data rate indicated that the error rates of the microwave system were comparable to those of a hardwired system. During these test intervals, complex manipulator operations were performed, and the AIMS transporter was moved repeatedly without adverse effects on data integrity. Results of these tests have been factored into subsequent phases of the development program, with an ultimate goal of designing a fully radiation-hardened microwave signal transmission system for use in nuclear facilities

  15. Radiation response of two Harris semiconductor radiation hardened 1k CMOS RAMs

    International Nuclear Information System (INIS)

    Abare, W.E.; Huffman, D.D.; Moffett, G.E.

    1982-01-01

    This paper describes the testing of two types 1K CMOS static RAMs in various transient and steady state ionizing radiation environments. Type HM 6551R (256x4 bits) and type HM 6508R (1024x1 bit) RAMs were evaluated. The RAMs are radiation hardened versions of Harris' commercial RAMs. A brief description of the radiation hardened process is presented

  16. Effect of dynamic strain aging on isotropic hardening in low cycle fatigue for carbon manganese steel

    International Nuclear Information System (INIS)

    Huang, Zhi Yong; Chaboche, Jean-Louis; Wang, Qing Yuan; Wagner, Danièle; Bathias, Claude

    2014-01-01

    Carbon–manganese steel A48 (French standard) is used in steam generator pipes of nuclear reactor pressure vessels at high temperatures (about 200 °C). The steel is sensitive to dynamic strain aging in monotonic tensile test and low cycle fatigue test at certain temperature range and strain rate. Its isotropic hardening behavior observed from experiments has a hardening, softening and hardening evolution with the effect of dynamic strain aging. The isotropic hardening model is improved by coupling the dislocation and dynamic strain aging theory to describe the behavior of A48 at 200 °C

  17. Effect of dynamic strain aging on isotropic hardening in low cycle fatigue for carbon manganese steel

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Zhi Yong, E-mail: huangzy@scu.edu.cn [Sichuan University, School of Aeronautics and Astronautics, No. 29 Jiuyanqiao Wangjiang Road, Chengdu 610064 (China); Chaboche, Jean-Louis [ONERA, DMSM, 29 avenue de la Division Lecerc, F-92320 Chatillon (France); Wang, Qing Yuan [Sichuan University, School of Aeronautics and Astronautics, No. 29 Jiuyanqiao Wangjiang Road, Chengdu 610064 (China); Wagner, Danièle; Bathias, Claude [Université ParisOuest Nanterre La Défense (France)

    2014-01-01

    Carbon–manganese steel A48 (French standard) is used in steam generator pipes of nuclear reactor pressure vessels at high temperatures (about 200 °C). The steel is sensitive to dynamic strain aging in monotonic tensile test and low cycle fatigue test at certain temperature range and strain rate. Its isotropic hardening behavior observed from experiments has a hardening, softening and hardening evolution with the effect of dynamic strain aging. The isotropic hardening model is improved by coupling the dislocation and dynamic strain aging theory to describe the behavior of A48 at 200 °C.

  18. Texture, deformation twinning and hardening in a newly developed Mg-Dy-Al-Zn-Zr alloy processed with high pressure torsion

    Czech Academy of Sciences Publication Activity Database

    Kocich, R.; Kunčická, L.; Král, Petr; Lowe, T. C.

    2016-01-01

    Roč. 90, JAN (2016), s. 1092-1099 ISSN 0264-1275 Institutional support: RVO:68081723 Keywords : Magnesium * High pressure torsion * Texture * Deformation twinning * Hardening Subject RIV: JG - Metallurgy Impact factor: 4.364, year: 2016

  19. Plasma nitriding - an eco friendly surface hardening process

    International Nuclear Information System (INIS)

    Mukherjee, S.

    2015-01-01

    Surface hardening is a process of heating the metal such that the surface gets only hardened. This process is adopted for many components like gears, cams, and crankshafts, which desire high hardness on the outer surface with a softer core to withstand the shocks. So, to attain such properties processes like carburising, nitriding, flame hardening and induction hardening are employed. Amongst these processes nitriding is the most commonly used process by many industries. In nitriding process the steel material is heated to a temperature of around 550 C and then exposed to atomic nitrogen. This atomic nitrogen reacts with iron and other alloying elements and forms nitrides, which are very hard in nature. By this process both wear resistance and hardness of the product can be increased. The atomic nitrogen required for this process can be obtained using ammonia gas (gas nitriding), cyanide based salt bath (liquid nitriding) and plasma medium (plasma nitriding). However, plasma nitriding has recently received considerable industrial interest owing to its characteristic of faster nitrogen penetration, short treatment time, low process temperature, minimal distortion, low energy use and easier control of layer formation compared with conventional techniques such as gas and liquid nitriding. This process can be used for all ferrous materials including stainless steels. Plasma nitriding is carried out using a gas mixture of nitrogen and hydrogen gas at sub atmospheric pressures hence, making it eco-friendly in nature. Plasma nitriding allows modification of the surface layers and hardness profiles by changing the gas mixture and temperature. The wide applicable temperature range enables a multitude of applications, beyond the possibilities of gas or salt bath processes. This has led to numerous applications of this process in industries such as the manufacture of machine parts for plastics and food processing, packaging and tooling as well as pumps and hydraulic, machine

  20. Applicability of Voce equation for tensile flow and work hardening behaviour of P92 ferritic steel

    International Nuclear Information System (INIS)

    Sainath, G.; Choudhary, B.K.; Christopher, J.; Isaac Samuel, E.; Mathew, M.D.

    2015-01-01

    Detailed analysis of true stress (σ)-true plastic strain (ε) data indicated that tensile flow behaviour of P92 ferritic steel can be adequately described by Voce equation at strain rates ranging from 3.16 × 10 −5 to 1.26 × 10 −3  s −1 over a temperature range 300–923 K. The steel exhibited two-stage work hardening in the variations of instantaneous work hardening rate (θ = dσ/dε) with stress. At all the strain rates, the variations in σ-ε, θ-σ and work hardening parameters associated with Voce equation with temperature exhibited three distinct temperature regimes. At intermediate temperatures, the variations in σ-ε, θ-σ and work hardening parameters with temperature and strain rate exhibited anomalous behaviour due to the occurrence of dynamic strain ageing in the steel. The shift in θ-σ towards low stresses, and rapid decrease in flow stress and work hardening parameters with increasing temperature and decreasing strain rate suggested dominance of dynamic recovery at high temperatures. - Highlights: • Tensile flow and work hardening behaviour of P92 steel has been examined. • Applicability of Voce equation to P92 steel is demonstrated. • Three temperature regimes in flow and work hardening has been observed. • Good match between predicted and the experimental tensile properties has been shown

  1. Nanoparticle amount, and not size, determines chain alignment and nonlinear hardening in polymer nanocomposites

    Science.gov (United States)

    Varol, H. Samet; Meng, Fanlong; Hosseinkhani, Babak; Malm, Christian; Bonn, Daniel; Bonn, Mischa; Zaccone, Alessio

    2017-01-01

    Polymer nanocomposites—materials in which a polymer matrix is blended with nanoparticles (or fillers)—strengthen under sufficiently large strains. Such strain hardening is critical to their function, especially for materials that bear large cyclic loads such as car tires or bearing sealants. Although the reinforcement (i.e., the increase in the linear elasticity) by the addition of filler particles is phenomenologically understood, considerably less is known about strain hardening (the nonlinear elasticity). Here, we elucidate the molecular origin of strain hardening using uniaxial tensile loading, microspectroscopy of polymer chain alignment, and theory. The strain-hardening behavior and chain alignment are found to depend on the volume fraction, but not on the size of nanofillers. This contrasts with reinforcement, which depends on both volume fraction and size of nanofillers, potentially allowing linear and nonlinear elasticity of nanocomposites to be tuned independently. PMID:28377517

  2. Molecular characterization of tlyA gene product, Rv1694 of Mycobacterium tuberculosis: A non-conventional hemolysin and a ribosomal RNA methyl transferase

    Directory of Open Access Journals (Sweden)

    Ahmed Neesar

    2010-09-01

    Full Text Available Abstract Background Mycobacterium tuberculosis is a virulent bacillus causing tuberculosis, a disease responsible for million deaths each year worldwide. In order to understand its mechanism of pathogenesis in humans and to help control tuberculosis, functions of numerous Mycobacterium tuberculosis genes are being characterized. In this study we report the dual functionality of tlyA gene product of Mycobacterium tuberculosis annotated as Rv1694, a 268 amino acid long basic protein. Results The recombinant purified Rv1694 protein was found to exhibit hemolytic activity in vitro. It showed concentration and time-dependent hemolysis of rabbit and human erythrocytes. Multiple oligomeric forms (dimers to heptamers of this protein were seen on the membranes of the lysed erythrocytes. Like the oligomers of conventional, well-known, pore-forming toxins, the oligomers of Rv1694 were found to be resistant to heat and SDS, but were susceptible to reducing agents like β-mercaptoethanol as it had abolished the hemolytic activity of Rv1694 indicating the role of disulfide bond(s. The Rv1694 generated de novo by in vitro transcription and translation also exhibited unambiguous hemolysis confirming the self assembly and oligomerization properties of this protein. Limited proteolytic digestion of this protein has revealed that the amino terminus is susceptible while in solution but is protected in presence of membrane. Striking feature of Rv1694 is its presence on the cell wall of E. coli as visualized by confocal microscopy. The surface expression is consistent with the contact dependent haemolytic ability of E. coli expressing this protein. Also, immune serum specific to this protein inhibits the contact dependent hemolysis. Moreover, Rv1694 protein binds to and forms stable oligomers on the macrophage phagosomal membranes. In addition to all these properties, E. coli expressing Rv1694 was found to be susceptible to the antibiotic capreomycin as its growth

  3. An energy-based beam hardening model in tomography

    International Nuclear Information System (INIS)

    Casteele, E van de; Dyck, D van; Sijbers, J; Raman, E

    2002-01-01

    As a consequence of the polychromatic x-ray source, used in micro-computer tomography (μCT) and in medical CT, the attenuation is no longer a linear function of absorber thickness. If this nonlinear beam hardening effect is not compensated, the reconstructed images will be corrupted by cupping artefacts. In this paper, a bimodal energy model for the detected energy spectrum is presented, which can be used for reduction of artefacts caused by beam hardening in well-specified conditions. Based on the combination of the spectrum of the source and the detector efficiency, the assumption is made that there are two dominant energies which can describe the system. The validity of the proposed model is examined by fitting the model to the experimental datapoints obtained on a microtomograph for different materials and source voltages

  4. Niobium effects on the austenitic grain growth and hardenability of steels for mechanical construction

    International Nuclear Information System (INIS)

    Vieira, R.R.; Arruda Camargo, L.M. de; Oliveira Junior, G.G. de; Dias Filho, A.G.C.

    1983-01-01

    The austenitic grain growth and hardenability of SAE 86XX and 5120 steels modified with 0,001 to 0,20 per-cent niobium content were studied when submitted to case hardening and quenching heat treatments. The results show that niobium controlS the austenite grain size better than molybdenum up to 950 0 C austenitization temperature. The hardenability, evaluated by the Jominy test which the modified SAE 8640 steels, is more strongly inflencied by the grain refining resulting from niobium addition than by any other supposed effect. (Author) [pt

  5. Precipitation hardening of a Cu-free Au-Ag-Pd-In dental alloy

    Energy Technology Data Exchange (ETDEWEB)

    Seol, Hyo-Joung [Department of Dental Materials, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, 1-10 Ami-dong, Seo-gu, Pusan 602-739 (Korea, Republic of); Son, Kuk-Hyeon [Department of Dental Materials, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, 1-10 Ami-dong, Seo-gu, Pusan 602-739 (Korea, Republic of); Yu, Chin-Ho [Department of Dental Materials, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, 1-10 Ami-dong, Seo-gu, Pusan 602-739 (Korea, Republic of); Kwon, Yong Hoon [Department of Dental Materials, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, 1-10 Ami-dong, Seo-gu, Pusan 602-739 (Korea, Republic of); Kim, Hyung-Il [Department of Dental Materials, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, 1-10 Ami-dong, Seo-gu, Pusan 602-739 (Korea, Republic of)]. E-mail: hilkim@pusan.ac.kr

    2005-10-27

    The hardening mechanism and related microstructural changes of the Cu-free dental casting alloy composed of Au-Ag-Pd-In was examined by means of hardness test, X-ray diffraction (XRD), scanning electron microscopic (SEM) observations and electron probe microanalysis (EPMA). The Au-Ag-Pd-In alloy showed apparent age-hardenability. In the SEM photograph, three phases were observed in the solution-treated specimen, that is, the Au-Ag based phase with small amounts of In and Pd as matrix, the InPd phase as particle-like structures, and the Pd-rich phase as lamellar precipitates. By aging the specimen, the very fine Pd-rich inter-granular precipitates grew toward the grain interior as lamellar structure, and finally the coarsened Pd-rich precipitates covered a large part of the Au-Ag based matrix. The hardness increase in the early stage of the age-hardening process was assumed to be caused by the diffusion and aggregation of Pd atoms from the Au-Ag based matrix. The hardness decrease in the later stage of age-hardening process was caused by coarsening of the lamellar precipitates composed of the Pd-rich phase.

  6. Precipitation hardening of a Cu-free Au-Ag-Pd-In dental alloy

    International Nuclear Information System (INIS)

    Seol, Hyo-Joung; Son, Kuk-Hyeon; Yu, Chin-Ho; Kwon, Yong Hoon; Kim, Hyung-Il

    2005-01-01

    The hardening mechanism and related microstructural changes of the Cu-free dental casting alloy composed of Au-Ag-Pd-In was examined by means of hardness test, X-ray diffraction (XRD), scanning electron microscopic (SEM) observations and electron probe microanalysis (EPMA). The Au-Ag-Pd-In alloy showed apparent age-hardenability. In the SEM photograph, three phases were observed in the solution-treated specimen, that is, the Au-Ag based phase with small amounts of In and Pd as matrix, the InPd phase as particle-like structures, and the Pd-rich phase as lamellar precipitates. By aging the specimen, the very fine Pd-rich inter-granular precipitates grew toward the grain interior as lamellar structure, and finally the coarsened Pd-rich precipitates covered a large part of the Au-Ag based matrix. The hardness increase in the early stage of the age-hardening process was assumed to be caused by the diffusion and aggregation of Pd atoms from the Au-Ag based matrix. The hardness decrease in the later stage of age-hardening process was caused by coarsening of the lamellar precipitates composed of the Pd-rich phase

  7. SU-E-T-599: Patient Safety Enhancements Through a Study of R&V System Override Data

    Energy Technology Data Exchange (ETDEWEB)

    Hendrickson, K; Vimolchalao, S [University of Washington, Seattle, WA (United States)

    2015-06-15

    Purpose: Record and verify (R&V) software systems include safety checks that compare actual machine parameters with prescribed values for a patient’s treatment, such as treatment couch position, linac, energy, and MUs. The therapist is warned of a mismatch with a pop-up and prompted to approve an override in order to continue without changes. Override approval is often legitimate, but the pop-up can also genuinely indicate a problem that would Result in the wrong treatment. When there are numerous pop-up warnings, human nature leads us to approve any override without careful reading, undermining the effectiveness of the safety mechanism. Methods: Override data was collected from our R&V system for all patients treated between October 8 and 29, 2012, on four linacs and entered into a spreadsheet. Additional data collected included treatment technique, disease site, immobilization, time, linac, and whether localization images were obtained. Data were analyzed using spreadsheet tools to reveal trends, patterns and associations that might suggest appropriate process changes that could decrease the total number of overrides. Results: 76 out of 113 patients had overrides. Out of the 944 treatments, 599 override items were generated. The majority were due to couch positions. 74 of the 84 overrides on a linac equipped with a 6D couch were due to the use of the rotational corrections and the fact that the 6D couch control does not communicate with the R&V system; translations required to rotate the couch appear to the R&V system as translations outside the tolerance range. Conclusion: Many findings were interesting but did not suggest a process change. Proposed process changes include creating site-specific instead of just technique-specific tolerance tables for couch shifts. Proposed improvements to the vendor are to facilitate direct communication between the 6D couch and the R&V system to eliminate those override warnings related to lack of communication.

  8. Hardened Solar Array High Temperature Adhesive.

    Science.gov (United States)

    1981-04-01

    SHERWOOO. D SASIU.IS F3361S-0-C-201S UNCLASSI ED 1AC-SCG-IOOIIR AFVAL-TR-OL-201? NLm,,hinii EhhhEE11I1 AFWAL-TR-81- 2017 i : HARDENED SOLAR ARRAY D HIGH...Tg and as a consequence forms a film on the container and also precipitates as tacky waxlike particles, rather than the desired flocullated

  9. Effect of Nonlinear Hardening of Lead Rubber Bearing on Long Term Behavior of Base Isolated Containment Building

    International Nuclear Information System (INIS)

    Park, Junhee; Choun, Young-Sun; Kim, Min-Kyu

    2015-01-01

    The rubber material used in laminated rubber bearings is the hyper elastic material whose stress-strain relationship can be defined as nonlinearly elastic. From the previous research, it was presented that the rubber hardness and stiffness was increased by the aging of LRB. The mechanical properties of LRB changed by aging can directly affect a nonlinear hardening behavior. Therefore it is needed to consider the nonlinear hardening effect for exactly evaluating the seismic safety of base isolated structure during the life time. In this study, the seismic response analysis of base isolated containment building was performed by using the bilinear model and the hardening model to identify the effect of structural response on the nonlinear hardening behavior of isolator. Moreover the floor response spectrum of base isolated structure considering the aging was analyzed by according to the analysis model of LRB.. The hardening behavior of lead rubber bearing occurs at high strain. Therefore it is reasonable to assume that the hysteretic model of LRB is the nonlinear hardening model for exactly evaluating the seismic response of base isolated structure. The nonlinear analysis of base isolated containment was performed by using the nonlinear hardening variables which was resulted from the test results and finite element analysis. From the analysis results, it was represented that the FRS was higher about 40% with nonlinear hardening model than with the bilinear model. Therefore the seismic response of base isolated structure with bilinear model can be underestimated than the real response. It is desired that the nonlinear hardening model of LRB is applied for the seismic risk evaluation requiring the ultimate state of LRB

  10. Physical and chemical data collected by bottle and CTD in the Gulf of Mexico from the R/V Gyre and R/V Pelican, April 2004 - July 2009 to help resolve the dominant oceanographic processes that control the timing, duration, and severity of hypoxia of the region (NODC Accession 0088164)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Physical and chemical oceanographic observational data collected by bottle and CTD in the Gulf of Mexico from the R/V Gyre and R/V Pelican, April 2004 - July 2009....

  11. A Novel Radiation Hardened CAM

    CERN Document Server

    Shojaii, Seyed Ruhollah; The ATLAS collaboration

    2018-01-01

    This poster describes an innovative Content Addressable Memory cell with radiation hardened (RH-CAM) architecture. The RH-CAM is designed in a commercial 28 nm CMOS technology. The circuit has been simulated in worst-case conditions, and the effects due to single particles are analyzed injecting a fault current into a circuit node. The proposed architecture can perform on-time pattern recognition tasks in harsh environments, such as very front-end electronics in hadron colliders and in space applications.

  12. Work hardening characteristics of gamma-ray irradiated Al-5356 alloy

    International Nuclear Information System (INIS)

    Saad, G.; Fayek, S.A.; Fawzy, A.; Soliman, H.N.; Nassr, E.

    2014-01-01

    Effects of γ-irradiation and deformation temperatures on the hardening behavior of Al-5356 alloy have been investigated by means of stress–strain measurements. Wire samples irradiated with different doses (ranging from 500 to 2000 kGy) were strained at different deformation temperatures T w (ranging from 303 to 523 K) and a constant strain rate of 1.5×10 −3 s −1 . The effect of γ-irradiation on the work-hardening parameters (WHP): yield stress σ y , fracture stress σ f , total strain ε T and work-hardening coefficient χ p of the given alloy was studied at the applied deformation temperature range. The obtained results showed that γ-irradiation exhibited an increase in the WHP of the given alloy while the increase in its deformation temperature showed a reverse effect. The mean activation energy of the deformation process was calculated using an Arrhenius-type relation, and was found to be ∼80 kJ/mole, which is close to that of grain boundary diffusion in aluminum alloys

  13. Design cost scoping studies. Nevada Test Site Terminal Waste Storage Program, Subtask 1.3: facility hardening studies

    International Nuclear Information System (INIS)

    Yanev, P.I.; Owen, G.N.

    1978-04-01

    As part of a program being conducted by the U.S. Department of Energy, Nevada Operations Office, to determine the feasibility of establishing a terminal waste storage repository at the Nevada Test Site, URS/John A. Blume and Associates, Engineers, made approximate determinations of the additional costs required to provide protection of structures against seismic forces. A preliminary estimate is presented of the added costs required to harden the surface structures, underground tunnels and storage rooms, and vertical shafts of the repository against ground motion caused by earthquakes and underground nuclear explosions (UNEs). The conceptual design of all of the structures was adapted from proposed bedded-salt waste-isolation repositories. Added costs for hardening were calculated for repositories in three candidate geological materials (Eleana argillite, Climax Stock granite, and Jackass Flats tuff) for several assumed peak ground accelerations caused by earthquakes (0.3g, 0.5g, and 0.7g) and by UNEs (0.5g, 0.7g, and 1.0g). Hardening procedures to protect the tunnels, storage rooms, and shafts against incremental seismic loadings were developed from (1) qualitative considerations of analytically determined seismic stresses and (2) engineering evaluations of the dynamic response of the rock mass and the tunnel support systems. The added costs for seismic hardening of the surface structures were found to be less than 1% of the estimated construction cost of the surface structures. For the underground structures, essentially no hardening was required for peak ground accelerations up to 0.3g; however, added costs became significant at 0.5g, with a possible increase in structural costs for the underground facilities of as much as 35% at 1.0g

  14. Medios de enfriamiento para el temple // Means for Cooling During the Hardening Process

    Directory of Open Access Journals (Sweden)

    N. Caballero Stevens

    1999-07-01

    Full Text Available Los factores que rigen el proceso de temple son la temperatura, el tiempo de calentamiento y la velocidad de enfriamiento.Tradicionalmente, la variación de la velocidad de enfriamiento se ha logrado mediante la utilización de diferentes medios como elagua, aceites minerales, aceites orgánicos, metales fundidos y otros.En este trabajo, se presentan las características fundamentales de los medios convencionales y actuales empleados para elenfriamiento durante el temple.Palabras claves: Endurecimiento superficial, temple superficial, medios de enfriamiento._____________________________________________________________________AbstractFactors governing of the hardening process are temperature, heating time and cooling speed. Traditionally, the variation of thecooling time has been achieved by using different means such as water, mineral oils, molten metals, etc.In this work, the fundamental characteristics of the conventional and modern means developed for cooling during the hardeningprocess are presented.Key words: Hardening process, cooling means.

  15. Current meter and other data collected using current meter casts from R/V RESEARCHER and R/V CALANUS in the Atlantic and Pacific Ocean as part of the Eastern Pacific Ocean Circulation Study (EPOCS) and Subtropical Atlantic Current Study (STACS), 23 March 1983 - 19 November 1986 (NODC Accession 8700226)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Current meter and other data were collected using current meter casts from R/V RESEARCHER and R/V CALANUS in the Atlantic and Pacific Ocean from March 23, 1983 to...

  16. Resonant frequency and elastic modulus measurements on hardened cement pastes

    International Nuclear Information System (INIS)

    Lee, D.J.

    1982-12-01

    A new technique for measuring resonant frequency and elastic modulus is described. This has been used on specimens of hardened cement paste containing water with no simulated waste, and the results compared with measurements of ultrasonic pulse velocity, dimensional movements and compressive strength made on the same formulations. In addition, measurements were made on a specimen containing simulated waste which demonstrated the applicability of the new technique for following the development of the mechanical properties of cemented simulant radioactive waste in the laboratory. (U.K.)

  17. Nitrogen nutrition and drought hardening exert opposite effects on the stress tolerance of Pinus pinea L. seedlings.

    Science.gov (United States)

    Villar-Salvador, Pedro; Peñuelas, Juan L; Jacobs, Douglass F

    2013-02-01

    Functional attributes determine the survival and growth of planted seedlings in reforestation projects. Nitrogen (N) and water are important resources in the cultivation of forest species, which have a strong effect on plant functional traits. We analyzed the influence of N nutrition on drought acclimation of Pinus pinea L. seedlings. Specifically, we addressed if high N fertilization reduces drought and frost tolerance of seedlings and whether drought hardening reverses the effect of high N fertilization on stress tolerance. Seedlings were grown under two N fertilization regimes (6 and 100 mg N per plant) and subjected to three drought-hardening levels (well-watered, moderate and strong hardening). Water relations, gas exchange, frost damage, N concentration and growth at the end of the drought-hardening period, and survival and growth of seedlings under controlled xeric and mesic outplanting conditions were measured. Relative to low-N plants, high-N plants were larger, had higher stomatal conductance (27%), residual transpiration (11%) and new root growth capacity and closed stomata at higher water potential. However, high N fertilization also increased frost damage (24%) and decreased plasmalemma stability to dehydration (9%). Drought hardening reversed to a great extent the reduction in stress tolerance caused by high N fertilization as it decreased frost damage, stomatal conductance and residual transpiration by 21, 31 and 24%, respectively, and increased plasmalemma stability to dehydration (8%). Drought hardening increased tissue non-structural carbohydrates and N concentration, especially in high-fertilized plants. Frost damage was positively related to the stability of plasmalemma to dehydration (r = 0.92) and both traits were negatively related to the concentration of reducing soluble sugars. No differences existed between moderate and strong drought-hardening treatments. Neither N nutrition nor drought hardening had any clear effect on seedling

  18. BUSFET - A Novel Radiation-Hardened SOI Transistor

    International Nuclear Information System (INIS)

    Schwank, J.R.; Shaneyfelt, M.R.; Draper, B.L.; Dodd, P.E.

    1999-01-01

    The total-dose hardness of SOI technology is limited by radiation-induced charge trapping in gate, field, and SOI buried oxides. Charge trapping in the buried oxide can lead to back-channel leakage and makes hardening SOI transistors more challenging than hardening bulk-silicon transistors. Two avenues for hardening the back-channel are (1) to use specially prepared SOI buried oxides that reduce the net amount of trapped positive charge or (2) to design transistors that are less sensitive to the effects of trapped charge in the buried oxide. In this work, we propose a new partially-depleted SOI transistor structure that we call the BUSFET--Body Under Source FET. The BUSFET utilizes a shallow source and a deep drain. As a result, the silicon depletion region at the back channel caused by radiation-induced charge trapping in the buried oxide does not form a conducting path between source and drain. Thus, the BUSFET structure design can significantly reduce radiation-induced back-channel leakage without using specially prepared buried oxides. Total dose hardness is achieved without degrading the intrinsic SEU and dose rate hardness of SOI technology. The effectiveness of the BUSFET structure for reducing total-dose back-channel leakage depends on several variables, including the top silicon film thickness and doping concentration and the depth of the source. 3-D simulations show that for a doping concentration of 10 18 cm -3 and a source depth of 90 nm, a silicon film thickness of 180 nm is sufficient to almost completely eliminate radiation-induced back-channel leakage. However, for a doping concentration of 3x10 17 cm -3 , a thicker silicon film (300 nm) must be used

  19. The application and processing of paints hardened by electron beams

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    Electron beam hardening is a process for changing liquid surface coatings of different thicknesses by irradiation with electrons of high energy into solid, hard, elastic films. In contrast to the UV process, one can harden pigmented paints with electron beams. An electron accelerator, which remits free electrons is used as the energy source for starting the chemical reaction in the coating material. In order to irradiate flat parts, which were coated with liquid paint by rolling, pouring or spraying, equally with electrons, one must produce an 'electron curtain', similar to that in a paint pouring machine. (orig./PW) [de

  20. Microstructure and properties of cast iron after laser surface hardening

    Directory of Open Access Journals (Sweden)

    Stanislav

    2013-12-01

    Full Text Available Laser surface hardening of cast iron is not trivial due to the material’s heterogeneity and coarse-grained microstructure, particularly in massive castings. Despite that, hardening of heavy moulds for automotive industry is in high demand. The present paper summarises the findings collected over several years of study of materials structure and surface properties. Phase transformations in the vicinity of graphite are described using examples from production of body parts in automotive industry. The description relates to formation of martensite and carbide-based phases, which leads to hardness values above 65 HRC and to excellent abrasion resistance.

  1. Changes in hardness of magnesium alloys due to precipitation hardening

    Directory of Open Access Journals (Sweden)

    Tatiana Oršulová

    2018-04-01

    Full Text Available This paper deals with the evaluation of changes in hardness of magnesium alloys during precipitation hardening that are nowadays widely used in different fields of industry. It focuses exactly on AZ31, AZ61 and AZ91 alloys. Observing material hardness changes serves as an effective tool for determining precipitation hardening parameters, such as temperature and time. Brinell hardness measurement was chosen based on experimental needs. There was also necessary to make chemical composition analysis and to observe the microstructures of tested materials. The obtained results are presented and discussed in this paper.

  2. Evaluation of combined hardening parameters for type 304LN stainless steel under strain-controlled cyclic loading

    International Nuclear Information System (INIS)

    Kumar, Abhishek; Vishnuvardhan, S.; Raghava, G.

    2016-01-01

    Low cycle fatigue (LCF) is the primary degradation mechanism affecting coolant piping of pressurized water reactor (PWR) caused by combination of pressure and transient mechanical or thermal loads. In the case of LCF, stresses are high enough for plastic deformation to occur and the fatigue life is correlated with the cyclic plastic strain. Modelling cyclic plastic deformation of a material requires hardening parameters, which have to be obtained from LCF test results. It is customary in low cycle fatigue tests that the strain ranges are kept constant and the stresses are allowed to vary which typically leads to a hysteresis loop that consists of linear and nonlinear parts. In this paper, numerical studies on mechanical behaviour of Type 304LN stainless steel under fully reversed strain-controlled cyclic loading have been carried out. A linear combination of the two hardening types, isotropic and kinematic, governed by a scalar parameter, β (0 ≤β ≤ 1) is used. A value of β=1 indicates a pure isotropic hardening while a value of β=0 indicates pure kinematic hardening. The details of the combined isotropic-kinematic hardening model are also presented. Constitutive relations for the classical von Mises theory along with a bilinear hardening theory have been used. The model is implemented in finite element software ABAQUS using a user subroutine written in FORTRAN, UMAT. An iterative method is adopted to arrive at the model's hardening parameters and the value of β. (author)

  3. Secondary Hardening Behavior in Super Duplex Stainless Steels during LCF in Dynamic Strain Ageing Regime

    OpenAIRE

    Chai, Guocai; Andersson, Marcus

    2013-01-01

    Cyclic deformation behaviors in five modified duplex stainless steel S32705 grades have been studied at 20 °C, 200 °C, 250° and 350 °C. The influence of temperature and nitrogen concentration on the occurrence of the second hardening phenomenon, in the stress response curve was focused. An increase in nitrogen concentration can have a positive effect on dynamic strain ageing by increasing the first hardening and also the second hardening behavior during cyclic deformation. Furthermore, an inc...

  4. Microstructural evolution and strain hardening behavior of the cold-drawn austenitic stainless steels

    International Nuclear Information System (INIS)

    Choi, Jeom Yong; Jin, Won

    1998-01-01

    The strain induced α ' -martensite formation and the strain hardening behavior of metastable austenitic stainless steel during cold drawing have been investigated. The strain induced α ' -martensite nucleates mainly at the intersection of the mechanical twins rather than ε-martensite. It could be explained by the increase of stacking fault energy which arises from the heat generated during high speed drawing and, for AISI 304/Cu, the additional effect of Cu additions. The strain hardening behavior of austenitic stainless steel is strongly related to the microstructural evolution accompanied by strain induced α ' -martensite. The work hardening rates of cold-drawn 304 increased with increasing interstitial element(C,N) contents which affect the strength of the strain induced α ' -martensite

  5. Instability analysis of a fully plastic center-cracked strip of a power hardening material

    International Nuclear Information System (INIS)

    Zahoor, A.; Paris, P.C.

    1978-01-01

    An approach for predicting unstable crack growth in a power hardening material is discussed. A fully plastic center-cracked strip of finite width under plane strain conditions, which involves J-controlled crack growth, is analyzed. The conditions for unstable crack growth are identified in terms of a non-dimensional parameter, the Tearing Modulus, T, which incorporates the effect of elastic system compliance on the cracked structure as well as the influence of hardening. Numerical results also illustrate the strong influences on stability of both the strain hardening characteristics of the material and certain geometrical proportions which greatly influence the system compliance. (author)

  6. PEMBUATAN PROGRAM INTERFACE UNTUK PENGONTROLAN RV-M1

    Directory of Open Access Journals (Sweden)

    Endra Endra

    2007-10-01

    Full Text Available Article explores the making of interface of RV-M1 hand robot control that replaced the cosiprog program,a program that is able to help student in Mecatronica-1 Practice, and able to control the hand robot by localnetwork by two user or more. The used methods were literature study, and field study, that is design method. Theresearch result are control of hand robot on X,Y,Z axis and point to point, the use of local network to control thehand robot, save certain position, and use several user to control the robot.Keywords: interface program, robot, local network

  7. Millisele õpetajale kingiksite imerohu? / Karl Martin Sinijärv, Vahur Keller, Kaarel Tarand ... [jt.

    Index Scriptorium Estoniae

    2010-01-01

    Küsimusele vastavad: Eesti kirjanike liidu esimees Karl Martin Sinijärv, nuku- ja noorsooteatri lavastaja Vahur Keller, Sirbi peatoimetaja Kaarel Tarand, kirjanik Andrus Kivirähk, ajakirjanik Juhani Püttsepp

  8. Numerical predicting of the structure and stresses state in hardened element made of tool steel

    Directory of Open Access Journals (Sweden)

    A. Bokota

    2008-03-01

    Full Text Available The paper presents numerical model of thcrmal phcnomcna, phasc transformation and mcchanical phcnomcna associated with hardeningof carbon tool steel. Model for evaluation or fractions OF phases and their kinetics bascd on continuous heating diagram (CHT andcontinuous cooling diagram (CCT. The stresses generated during hardening were assumed to rcsult from ~hermal load. stntcturaI plasticdeformations and transformation plasricity. Thc hardened material was assumed to be elastic-plastic, and in ordcr to mark plastic strains the non-isothermal plastic law of flow with the isotropic hardening and condition plasticity of Huber-Misses were used. TherrnophysicaI values of mechanical phenomena dependent on bo~hth e phase composition and temperature. In the numerical example thc simulated estimation of the phasc Fraction and strcss distributions in the hardened axisimmetrical elemcnt was performed.

  9. Development of a hardened X-ray imager for the Megajoule Laser radiative environment

    International Nuclear Information System (INIS)

    Rousseau, A.

    2014-01-01

    Thermonuclear fusion experiments are led on Megajoule class laser facility by imploding a capsule filled with Deuterium and Tritium. In this context, it is necessary to diagnose the core size and the shape of the compressed target in order to provide valuable information and identify reasons for failure. State of the art X-ray imaging diagnostics cannot realize measurements without being perturbed by the nuclear background. The diagnostic that has been designed in this thesis combine high spatial resolution X-ray imaging at high energy and radiation tolerance to nuclear background. We have first guaranteed, theoretically and experimentally, survivability of X ray multilayer coating to energetic neutrons irradiation. Consequently, we have design the X-ray imaging system in order to achieve 5 μm resolution in a spectral range up to 95 keV. The X-ray image has then been converted into visible light in order to be easily transferred through a hardened optical relay to a protected area where the optical analyser is set. This analyser, combining light amplifier and pixelised detector, has also been studied and a novel method has been developed to reduce nuclear related transient perturbations on the device. This by parts design associated with Monte-Carlo Simulation (GEANT4) and experimental campaign on FCI facility (OMEGA) led to a coherent diagnostic architecture which will sustain high level of nuclear perturbation. (author) [fr

  10. On the correlation between irradiation-induced microstructural features and the hardening of reactor pressure vessel steels

    International Nuclear Information System (INIS)

    Lambrecht, M.; Meslin, E.; Malerba, L.; Hernandez-Mayoral, M.; Bergner, F.; Pareige, P.; Radiguet, B.; Almazouzi, A.

    2010-01-01

    A correlation is attempted between microstructural observations by various complementary techniques, which have been implemented within the PERFECT project and the hardening measured by tensile tests of reactor pressure vessel steel and model alloys after irradiation to a dose of ∼7 x 10 19 n cm -2 . This is done, using the simple hardening model embodied by the Orowan equation and applying the most suitable superposition law, as suggested by a parametric study using the DUPAIR line tension code. It is found that loops are very strong obstacles to dislocation motion, but due to their low concentration, they only play a minor role in the hardening itself. For the precipitates, the contrary is found, although they are quite soft (due to their very small sizes and their coherent nature), they still play the dominant role in the hardening. Vacancy clusters are important for the formation of both loops and precipitates, but they will play almost no role in the hardening by themselves.

  11. Processing, Microstructures and Properties of a Dual Phase Precipitation-Hardening PM Stainless Steel

    Science.gov (United States)

    Schade, Christopher

    To improve the mechanical properties of PM stainless steels in comparison with their wrought counterparts, a PM stainless steel alloy was developed which combines a dual-phase microstructure with precipitation-hardening. The use of a mixed microstructure of martensite and ferrite results in an alloy with a combination of the optimum properties of each phase, namely strength and ductility. The use of precipitation hardening via the addition of copper results in additional strength and hardness. A range of compositions was studied in combination with various sintering conditions to determine the optimal thermal processing to achieve the desired microstructure. The microstructure could be varied from predominately ferrite to one containing a high percentage of martensite by additions of copper and a variation of the sintering temperature before rapid cooling. Mechanical properties (transverse rupture strength (TRS), yield strength, tensile strength, ductility and impact toughness) were measured as a function of the v/o ferrite in the microstructure. A dual phase alloy with the optimal combination of properties served as the base for introducing precipitation hardening. Copper was added to the base alloy at various levels and its effect on the microstructure and mechanical properties was quantified. Processing at various sintering temperatures led to a range of microstructures; dilatometry was used utilized to monitor and understand the transformations and the formation of the two phases. The aging process was studied as a function of temperature and time by measuring TRS, yield strength, tensile strength, ductility, impact toughness and apparent hardness. It was determined that optimum aging was achieved at 538°C for 1h. Aging at slightly lower temperatures led to the formation of carbides, which contributed to reduced hardness and tensile strength. As expected, at the peak aging temperature, an increase in yield strength and ultimate tensile strength as well as

  12. A method for hardening or curing adhesives for flocking thermally sensitive substrata by means of an electron-beam

    International Nuclear Information System (INIS)

    Nablo, S.V.; Fussa, A.D.

    1975-01-01

    The invention relates to a method for hardening or curing adhesives for flocking thermally sensitive substrata by means of an electron-beam. That method consists in accurately adjusting the parameters of irradiation by an electron-beam and the beam velocity so as to obtain, a very rapid hardening of adhesives used for fixing flocking materials, or the like, to thermally sensitive substrate. That can be applied to hardening or curing adhesives for flocking thermally-sensitive substrata which normally restrict the hardening rate [fr

  13. Conditions for pseudo strain-hardening in fiber reinforced brittle matrix composites

    International Nuclear Information System (INIS)

    Li, V.C.; Wu, H.W.

    1992-01-01

    Apart from imparting increased fracture toughness, one of the useful purposes of reinforcing brittle matrices with fibers is to create enhanced composite strain capacity. This paper reviews the conditions underwhich such a composite will exhibit the pseudo strain-hardening phenomenon. The presentation is given in a unified manner for both continuous aligned and discontinuous random fiber composites. It is demonstrated that pseudo strain hardening can be practically designed for both gills of composites by proper tailoring of material structures. 18 refs., 8 figs., 2 tabs

  14. Rapid hardening induced by electric pulse annealing in nanostructured pure aluminum

    DEFF Research Database (Denmark)

    Zeng, Wei; Shen, Yao; Zhang, Ning

    2012-01-01

    Nanostructured pure aluminum was fabricated by heavy cold-rolling and then subjected to recovery annealing either by applying electric pulse annealing or by traditional air furnace annealing. Both annealing treatments resulted in an increase in yield strength due to the occurrence of a “dislocation...... source-limited hardening” mechanism. However, the hardening kinetics was substantially faster for the electric pulse annealed material. Detailed microstructural characterization suggested that the rapid hardening during electric pulse annealing is related to an enhanced rate of recovery of dislocation...

  15. Heat Flow Data Cruise MD72 RV Marion Dufresne over the Mascarene Ridge

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data were gathered by the R/V Marion Dufresne in May and June of 1992 over the Mascarene Ridge in the Indian Ocean on cruise MD72/MASCAFLUX. Heat flow measurements...

  16. Strain hardening of cold-rolled lean-alloyed metastable ferritic-austenitic stainless steels

    Energy Technology Data Exchange (ETDEWEB)

    Papula, Suvi [Aalto University School of Engineering, Department of Mechanical Engineering, P.O. Box 14200, FI-00076 Aalto (Finland); Anttila, Severi [Centre for Advanced Steels Research, University of Oulu, P.O. Box 4200, 90014 Oulu (Finland); Talonen, Juho [Outokumpu Oyj, P.O. Box 245, FI-00181 Helsinki (Finland); Sarikka, Teemu; Virkkunen, Iikka; Hänninen, Hannu [Aalto University School of Engineering, Department of Mechanical Engineering, P.O. Box 14200, FI-00076 Aalto (Finland)

    2016-11-20

    Mechanical properties and strain hardening of two pilot-scale lean-alloyed ferritic-austenitic stainless steels having metastable austenite phase, present at 0.50 and 0.30 volume fractions, have been studied by means of tensile testing and nanoindentation. These ferritic-austenitic stainless steels have high strain-hardening capacity, due to the metastable austenite phase, which leads to an improved uniform elongation and higher tensile strength in comparison with most commercial lean duplex stainless steels. According to the results, even as low as 0.30 volume fraction of austenite seems efficient for achieving nearly 40% elongation. The austenite phase is initially the harder phase, and exhibits more strain hardening than the ferrite phase. The rate of strain hardening and the evolution of the martensite phase were found to depend on the loading direction: both are higher when strained in the rolling direction as compared to the transverse direction. Based on the mechanical testing, characterization of the microstructure by optical/electron microscopy, magnetic balance measurements and EBSD texture analysis, this anisotropy in mechanical properties of the cold-rolled metastable ferritic-austenitic stainless steels can be explained by the elongated dual-phase microstructure, fiber reinforcement effect of the harder austenite phase and the presence and interplay of rolling textures in the two phases.

  17. Study on the Influence of the Work Hardening Models Constitutive Parameters Identification in the Springback Prediction

    International Nuclear Information System (INIS)

    Oliveira, M.C.; Menezes, L. F.; Alves, J.L.; Chaparro, B.M.

    2005-01-01

    The main goal of this work is to determine the influence of the work hardening model in the numerical prediction of springback. This study will be performed according with the specifications of the first phase of the 'Benchmark 3' of the Numisheet'2005 Conference: the 'Channel Draw'. Several work hardening constitutive models are used in order to allow a better description of the different material mechanical behavior. Two are classical pure isotropic hardening models described by a power law (Swift) or a Voce type saturation equation. Those two models were also combined with a non-linear (Lemaitre and Chaboche) kinematic hardening rule. The final one is the Teodosiu microstructural hardening model. The study is performed for two commonly used steels of the automotive industry: mild (DC06) and dual phase (DP600) steels. The mechanical characterization, as well as the constitutive parameters identification of each work hardening models, was performed by LPMTM, based on an appropriate set of experimental data such as uniaxial tensile tests, monotonic and Bauschinger simple shear tests and orthogonal strain path tests, all at various orientations with respect to the rolling direction. All the simulations were carried out with the CEMUC's home code DD3IMP (contraction of 'Deep Drawing 3-D IMPlicit code')

  18. Surface modification on PMMA : PVDF polyblend: hardening under ...

    Indian Academy of Sciences (India)

    Unknown

    Keywords. Polyblend; surface modification; microhardness; hardening; plasticization; segmental mobility. 1. Introduction. Polymeric materials have a specific feature of stability towards various aggressive chemical environments, which depends on a multiplicity of factors like structure and nature of the polymers and chemical ...

  19. Study of the mechanisms involved in the laser superficial hardening process of metallic alloys

    International Nuclear Information System (INIS)

    Silva, Edmara Marques Rodrigues da

    2001-01-01

    The laser superficial hardening process of a ferrous alloy (gray cast iron) and of an aluminum-silicon alloy was investigated in this work. These metallic alloys are used in the automobile industry for manufacturing cylinders and pistons, respectively. By application of individual pulses and single tracks, the involved mechanisms during the processing were studied. Variables such as energy density, power density, temporal width, beam diameter on the sample surface, atmosphere of the processing region, overlapping and scanning velocity. The hardened surface was characterized by optical and scanning electronic microscopy, dispersive energy microanalysis, X-ray mapping, X-ray diffraction, and measurements of roughness and Vickers microhardness. Depending on the processing parameters, it is possible to obtain different microstructures. The affected area of gray cast iron, can be hardened by remelting or transformation hardening (total or partial) if the reached temperature is higher or not that of melting temperature. Laser treatment originated new structures such as retained austenite, martensite and, occasionally, eutectic of cellular dendritic structure. Aluminum-silicon alloy does not have phase transformation in solid state, it can be hardened only by remelting. The increase of hardness is a function of the precipitation hardening process, which makes the silicon particles smaller and more disperse in the matrix. Maximal values of microhardness (700-1000 HV) were reached with the laser treatment in gray cast iron samples. The initial microhardness is of 242 HV. For aluminum-silicon alloy, the laser remelting increases the initial microhardness of 128 HV to the range of 160-320 HV. The found results give a new perspective for using the CLA/IPEN's laser in the heat treatment area. Besides providing a higher absorptivity to the materials, compared with the CO 2 laser, and optical fiber access, the superficial hardening with Nd:YAG laser, depending on the level of

  20. The Prognostic Impact of the Evolution of RV Function in Idiopathic DCM.

    Science.gov (United States)

    Merlo, Marco; Gobbo, Marco; Stolfo, Davide; Losurdo, Pasquale; Ramani, Federica; Barbati, Giulia; Pivetta, Alberto; Di Lenarda, Andrea; Anzini, Marco; Gigli, Marta; Pinamonti, Bruno; Sinagra, Gianfranco

    2016-09-01

    In this study, the authors analyzed the prognostic role of right ventricular systolic function (RVF) longitudinal trends in a large cohort of patients affected by dilated cardiomyopathy (DCM). RVF is a known prognostic predictor in DCM; however, whether RVF changes over time to better predict the long-term disease progression has not been investigated. From 1993 to 2008, we analyzed 512 patients with DCM (46 years of age [36 to 55 years of age], left ventricular ejection fraction 32% [25% to 41%]) with a potential follow-up of ≥72 months and available data at baseline and at least 1 pre-specified follow-up evaluation (i.e., 6, 24, 48, or 72 months). RV dysfunction was defined as RV fractional area change model, RVF revaluation over time maintained an independent predictive value (hazard ratio: 2.83; 95% CI: 1.57 to 5.11; p = 0.0006). Patients with DCM frequently present RV dysfunction at first evaluation. However, a complete RVF recovery is largely observed early after optimization of medical therapy and predates subsequent left ventricular reverse remodeling. Systematic revaluation of patients including RVF throughout regular follow-up conferred additive long-term prognostic value to the baseline evaluation. Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  1. Radiation dose effects, hardening of electronic components

    International Nuclear Information System (INIS)

    Dupont-Nivet, E.

    1991-01-01

    This course reviews the mechanism of interaction between ionizing radiation and a silicon oxide type dielectric, in particular the effect of electron-hole pairs creation in the material. Then effects of cumulated dose on electronic components and especially in MOS technology are examined. Finally methods hardening of these components are exposed. 93 refs

  2. Simulation-aided investigation of beam hardening induced errors in CT dimensional metrology

    DEFF Research Database (Denmark)

    Tan, Ye; Kiekens, Kim; Welkenhuyzen, Frank

    2014-01-01

    are mutually correlated, it remains challenging to interpret measurement results and to identify the distinct error sources. Since simulations allow isolating the different affecting factors, they form a useful complement to experimental investigations. Dewulf et al (2012 CIRP Ann. Manuf. Technol. 61 495......–8) investigated the influence of beam hardening correction parameters on the diameter of a calibrated steel pin in different experimental set-ups. It was clearly shown that an inappropriate beam hardening correction can result in significant dimensional errors. This paper confirms these results using simulations...... of a pin surrounded by a stepped cylinder: a clear discontinuity in the measured diameter of the inner pin is observed where it enters the surrounding material. The results are expanded with an investigation of the beam hardening effect on the measurement results for both inner and outer diameters...

  3. Efficient, radiation-hardened, 800-keV neutral beam injection system

    International Nuclear Information System (INIS)

    Anderson, O.A.; Cooper, W.S.; Goldberg, D.A.; Ruby, L.; Soroka, L.; Fink, J.H.

    1982-10-01

    Recent advances and new concepts in negative ion generation, transport, acceleration, and neutrailzation make it appear likely that an efficient, radiation-hardened neutral beam injection system could be developed in time for the proposed FED-A tokamak. These new developments include the operation of steady-state H - ion sources at over 5 A per meter of source length, the concept of using strong-focussing electrostatic structures for low-gradient dc acceleration of high-current sheet beams of negative ions and the transport of these beams around corners, and the development of powerful oxygen-iodine chemical lasers which will make possible the efficient conversion of the negative ions to neutrals using a photodetachment scheme in which the ion beam passes through the laser cavity

  4. Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases

    International Nuclear Information System (INIS)

    Premkumar, Lakshmanane; Heras, Begoña; Duprez, Wilko; Walden, Patricia; Halili, Maria; Kurth, Fabian; Fairlie, David P.; Martin, Jennifer L.

    2013-01-01

    The gene product of M. tuberculosis Rv2969c is shown to be a disulfide oxidase enzyme that has a canonical DsbA-like fold with novel structural and functional characteristics. The bacterial disulfide machinery is an attractive molecular target for developing new antibacterials because it is required for the production of multiple virulence factors. The archetypal disulfide oxidase proteins in Escherichia coli (Ec) are DsbA and DsbB, which together form a functional unit: DsbA introduces disulfides into folding proteins and DsbB reoxidizes DsbA to maintain it in the active form. In Mycobacterium tuberculosis (Mtb), no DsbB homologue is encoded but a functionally similar but structurally divergent protein, MtbVKOR, has been identified. Here, the Mtb protein Rv2969c is investigated and it is shown that it is the DsbA-like partner protein of MtbVKOR. It is found that it has the characteristic redox features of a DsbA-like protein: a highly acidic catalytic cysteine, a highly oxidizing potential and a destabilizing active-site disulfide bond. Rv2969c also has peptide-oxidizing activity and recognizes peptide segments derived from the periplasmic loops of MtbVKOR. Unlike the archetypal EcDsbA enzyme, Rv2969c has little or no activity in disulfide-reducing and disulfide-isomerase assays. The crystal structure of Rv2969c reveals a canonical DsbA fold comprising a thioredoxin domain with an embedded helical domain. However, Rv2969c diverges considerably from other DsbAs, including having an additional C-terminal helix (H8) that may restrain the mobility of the catalytic helix H1. The enzyme is also characterized by a very shallow hydrophobic binding surface and a negative electrostatic surface potential surrounding the catalytic cysteine. The structure of Rv2969c was also used to model the structure of a paralogous DsbA-like domain of the Ser/Thr protein kinase PknE. Together, these results show that Rv2969c is a DsbA-like protein with unique properties and a limited

  5. Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases

    Energy Technology Data Exchange (ETDEWEB)

    Premkumar, Lakshmanane, E-mail: p.lakshmanane@imb.uq.edu.au; Heras, Begoña; Duprez, Wilko; Walden, Patricia; Halili, Maria; Kurth, Fabian; Fairlie, David P.; Martin, Jennifer L., E-mail: p.lakshmanane@imb.uq.edu.au [University of Queensland, St Lucia, QLD 4067 (Australia)

    2013-10-01

    The gene product of M. tuberculosis Rv2969c is shown to be a disulfide oxidase enzyme that has a canonical DsbA-like fold with novel structural and functional characteristics. The bacterial disulfide machinery is an attractive molecular target for developing new antibacterials because it is required for the production of multiple virulence factors. The archetypal disulfide oxidase proteins in Escherichia coli (Ec) are DsbA and DsbB, which together form a functional unit: DsbA introduces disulfides into folding proteins and DsbB reoxidizes DsbA to maintain it in the active form. In Mycobacterium tuberculosis (Mtb), no DsbB homologue is encoded but a functionally similar but structurally divergent protein, MtbVKOR, has been identified. Here, the Mtb protein Rv2969c is investigated and it is shown that it is the DsbA-like partner protein of MtbVKOR. It is found that it has the characteristic redox features of a DsbA-like protein: a highly acidic catalytic cysteine, a highly oxidizing potential and a destabilizing active-site disulfide bond. Rv2969c also has peptide-oxidizing activity and recognizes peptide segments derived from the periplasmic loops of MtbVKOR. Unlike the archetypal EcDsbA enzyme, Rv2969c has little or no activity in disulfide-reducing and disulfide-isomerase assays. The crystal structure of Rv2969c reveals a canonical DsbA fold comprising a thioredoxin domain with an embedded helical domain. However, Rv2969c diverges considerably from other DsbAs, including having an additional C-terminal helix (H8) that may restrain the mobility of the catalytic helix H1. The enzyme is also characterized by a very shallow hydrophobic binding surface and a negative electrostatic surface potential surrounding the catalytic cysteine. The structure of Rv2969c was also used to model the structure of a paralogous DsbA-like domain of the Ser/Thr protein kinase PknE. Together, these results show that Rv2969c is a DsbA-like protein with unique properties and a limited

  6. Rv2131c gene product: An unconventional enzyme that is both inositol monophosphatase and fructose-1,6-bisphosphatase

    International Nuclear Information System (INIS)

    Gu Xiaoling; Chen Mao; Shen Hongbo; Jiang Xin; Huang Yishu; Wang Honghai

    2006-01-01

    Inositol monophosphatase is an enzyme in the biosynthesis of myo-inostiol, a crucial substrate for the synthesis of phosphatidylinositol, which has been demonstrated to be an essential component of mycobacteria. In this study, the Rv2131c gene from Mycobacterium tuberculosis H37Rv was cloned into the pET28a vector and the recombinant plasmid was transformed into Escherichia coli BL21 (DE3) strain, allowing the expression of the enzyme in fusion with a histidine-rich peptide on the N-terminal. The fusion protein was purified from the soluble fraction of the lysed cells under native conditions by immobilized metal affinity chromatography (IMAC). The purified Rv2131c gene product showed inositol monophosphatase activity but with substrate specificity that was broader than those of several bacterial and eukaryotic inositol monophosphatases, and it also acted as fructose-1,6-bisphosphatase. The dimeric enzyme exhibited dual activities of IMPase and FBPase, with K m of 0.22 ± 0.03 mM for inositol-1-phosphate and K m of 0.45 ± 0.05 mM for fructose-1,6-bisphosphatase. To better understand the relationship between the function and structure of the Rv2131c enzyme, we constructed D40N, L71A, and D94N mutants and purified these corresponding proteins. Mutations of D40N and D94N caused the proteins to almost completely lose both the inositol monophosphatase and fructose-1,6-bisphosphatase activities. However, L71A mutant did not cause loss either of the activities, but the activity toward the inositol was 12-fold more resistant to inhibition by lithium (IC 5 ∼ 60 mM). Based on the substrate specificity and presence of conserved sequence motifs of the M. tuberculosis Rv2131c, we proposed that the enzyme belonged to class IV fructose-1,6-bisphosphatase (FBPase IV)

  7. Radiation effects in semiconductors: technologies for hardened integrated circuits

    International Nuclear Information System (INIS)

    Charlot, J.M.

    1983-09-01

    Various technologies are used to manufacture integrated circuits for electronic systems. But for specific applications, including those with radiation environment, it is necessary to choose an appropriate technologie or to improve a specific one in order to reach a definite hardening level. The aim of this paper is to present the main effects induced by radiation (neutrons and gamma rays) into the basic semiconductor devices, to explain some physical degradation mechanisms and to propose solutions for hardened integrated circuit fabrication. The analysis involves essentially the monolithic structure of the integrated circuits and the isolation technology of active elements. In conclusion, the advantages of EPIC and SOS technologies are described and the potentialities of new technologies (GaAs and SOI) are presented

  8. Radiation effects in semiconductors: technologies for hardened integrated circuits

    International Nuclear Information System (INIS)

    Charlot, J.M.

    1984-01-01

    Various technologies are used to manufacture integrated circuits for electronic systems. But for specific applications, including those with radiation environment, it is necessary to choose an appropriate technology or to improve a specific one in order to reach a definite hardening level. The aim of this paper is to present the main effects induced by radiation (neutrons and gamma rays) into the basic semiconductor devices, to explain some physical degradation mechanisms and to propose solutions for hardened integrated circuit fabrication. The analysis involves essentially the monolithic structure of the integrated circuits and the isolation technology of active elements. In conclusion, the advantages of EPIC and SOS technologies are described and the potentialities of new technologies (GaAs and SOI) are presented. (author)

  9. Effects of residual stress on irradiation hardening in stainless steels

    Energy Technology Data Exchange (ETDEWEB)

    Okubo, N.; Kondo, K.; Kaji, Y. [Japan Atomic Energy Agency, Tokai-mura, Naga-gun, Ibaraki-ken (Japan); Miwa, Y. [Nuclear Energy and Science Directorate, Japan Atomic Energy Agency, Tokai-mura, Ibaraki-ken (Japan)

    2007-07-01

    Full text of publication follows: Structural materials in fusion reactor with water cooling system will undergo corrosion in aqueous environment and heavier irradiation than that in LWR. Irradiation assisted stress corrosion (IASCC) may be induced in stainless steels exposed in these environment for a long term of reactor operation. The IASCC is considered to be caused in a welding zone. It is difficult to predict and estimate the IASCC, because several irradiation effects (irradiation hardening, swelling, irradiation induced stress relaxation, etc) work intricately. Firstly, effects of residual stress on irradiation hardening were investigated in stainless steels. Specimens used in this study were SUS316 and SUS316L. By bending deformation, the specimens with several % plastic strain, which corresponds to weld residual stress, were prepared. Ion irradiations of 12 MeV Ni{sup 3+} were performed at 330, 400 and 550 deg. C to 45 dpa in TIARA facility at JAEA. No bent specimen was simultaneously irradiated with the bent specimen. The residual stress was estimated by X-ray residual stress measurements before and after the irradiation. The micro-hardness was measured by using nano-indenter. The irradiation hardening and the stress relaxation were changed by irradiation under bending deformation. The residual stress did not relax even for the case of the higher temperature aging at 500 deg. C for the same time of irradiation. The residual stress after ion irradiation, however, relaxed at these experimental temperatures in SUS316L. The hardness was obviously suppressed in bent SUS316L irradiated at 300 deg. C to 6 or 12 dpa. It was evident that irradiation induced stress relaxation occasionally suppressed the irradiation hardening in SUS316L. (authors)

  10. Accurate hardening modeling as basis for the realistic simulation of sheet forming processes with complex strain-path changes

    International Nuclear Information System (INIS)

    Levkovitch, Vladislav; Svendsen, Bob

    2007-01-01

    Sheet metal forming involves large strains and severe strain-path changes. Large plastic strains lead in many metals to the development of persistent dislocation structures resulting in strong flow anisotropy. This induced anisotropic behavior manifests itself in the case of a strain path change through very different stress-strain responses depending on the type of the strain-path change. While many metals exhibit a drop of the yield stress (Bauschinger effect) after a load reversal, some metals show an increase of the yield stress after an orthogonal strain-path change (so-called cross hardening). To model the Bauschinger effect, kinematic hardening has been successfully used for years. However, the usage of the kinematic hardening leads automatically to a drop of the yield stress after an orthogonal strain-path change contradicting tests exhibiting the cross hardening effect. Another effect, not accounted for in the classical elasto-plasticity, is the difference between the tensile and compressive strength, exhibited e.g. by some steel materials. In this work we present a phenomenological material model whose structure is motivated by polycrystalline modeling that takes into account the evolution of polarized dislocation structures on the grain level - the main cause of the induced flow anisotropy on the macroscopic level. The model considers besides the movement of the yield surface and its proportional expansion, as it is the case in conventional plasticity, also the changes of the yield surface shape (distortional hardening) and accounts for the pressure dependence of the flow stress. All these additional attributes turn out to be essential to model the stress-strain response of dual phase high strength steels subjected to non-proportional loading

  11. Accurate Hardening Modeling As Basis For The Realistic Simulation Of Sheet Forming Processes With Complex Strain-Path Changes

    International Nuclear Information System (INIS)

    Levkovitch, Vladislav; Svendsen, Bob

    2007-01-01

    Sheet metal forming involves large strains and severe strain-path changes. Large plastic strains lead in many metals to the development of persistent dislocation structures resulting in strong flow anisotropy. This induced anisotropic behavior manifests itself in the case of a strain path change through very different stress-strain responses depending on the type of the strain-path change. While many metals exhibit a drop of the yield stress (Bauschinger effect) after a load reversal, some metals show an increase of the yield stress after an orthogonal strain-path change (so-called cross hardening). To model the Bauschinger effect, kinematic hardening has been successfully used for years. However, the usage of the kinematic hardening leads automatically to a drop of the yield stress after an orthogonal strain-path change contradicting tests exhibiting the cross hardening effect. Another effect, not accounted for in the classical elasto-plasticity, is the difference between the tensile and compressive strength, exhibited e.g. by some steel materials. In this work we present a phenomenological material model whose structure is motivated by polycrystalline modeling that takes into account the evolution of polarized dislocation structures on the grain level - the main cause of the induced flow anisotropy on the macroscopic level. The model considers besides the movement of the yield surface and its proportional expansion, as it is the case in conventional plasticity, also the changes of the yield surface shape (distortional hardening) and accounts for the pressure dependence of the flow stress. All these additional attributes turn out to be essential to model the stress-strain response of dual phase high strength steels subjected to non-proportional loading

  12. Stress corrosion cracking evaluation of precipitation-hardening stainless steel

    Science.gov (United States)

    Humphries, T. S.; Nelson, E. E.

    1970-01-01

    Accelerated test program results show which precipitation hardening stainless steels are resistant to stress corrosion cracking. In certain cases stress corrosion susceptibility was found to be associated with the process procedure.

  13. Numerical simulations of progressive hardening by using ABAQUS FEA software

    Directory of Open Access Journals (Sweden)

    Domański Tomasz

    2018-01-01

    Full Text Available The paper concerns numerical simulations of progressive hardening include phase transformations in solid state of steel. Abaqus FEA software is used for numerical analysis of temperature field and phase transformations. Numerical subroutines, written in fortran programming language are used in computer simulations where models of the distribution of movable heat source, kinetics of phase transformations in solid state as well as thermal and structural strain are implemented. Model for evaluation of fractions of phases and their kinetics is based on continuous heating diagram and continuous cooling diagram. The numerical analysis of thermal fields, phase fractions and strain associated progressive hardening of elements made of steel were done.

  14. Effect of aluminizing on hardenability of steel (S45C)

    Science.gov (United States)

    Prayitno, D.; Sugiarto, R.

    2018-01-01

    The objective of research is to know the effect of aluminizing on hardenability of steel (S45C). The research methodologies were as follows. The Steels (S45C) were machined into the Jominy test samples. Next the samples were preheating at 700 ° C for 30 minutes and then the samples were dipped into the molten of aluminium for 3 minutes as a hot dip aluminizng method. The aluminium molten was 700 ° C. Then the samples were cooled into room temperatures. Finally the samples were into the jominy tested. The results show that the aluminizing (include the preheating process) increases the hardenability of steel (S45C).

  15. system hardening architecture for safer access to critical business

    African Journals Online (AJOL)

    eobe

    System hardening is a defence strategy, where several different security measures are applied at various layers, all of which .... commerce have tremendously imparted on corporate services ..... Technology and Exploring Engineering, Vol. 2,.

  16. On the hardenability of Nb-modified metastable beta Ti-5553 alloy

    Energy Technology Data Exchange (ETDEWEB)

    Campo, K.N.; Andrade, D.R.; Opini, V.C.; Mello, M.G.; Lopes, E.S.N.; Caram, R., E-mail: caram@fem.unicamp.br

    2016-05-15

    Among the commercially available titanium alloys, the metastable β Ti-5553 alloy (Ti–5Al–5V–5Mo–3Cr–0.5Fe wt.%) is an object of great interest because it is employed in aerospace structural applications, primarily in the replacement of steel components. One of the primary advantages of this alloy is its high hardenability, which allows it to retain the β phase at room temperature, even at low cooling rates, thereby allowing the thermoprocessing of thick parts. The aim of this investigation was to evaluate the effect of the replacement of V with Nb on the hardenability of Ti-5553. Based on the molybdenum equivalent criterion, the Nb-modified Ti-5553 alloy was designed to present 12 wt.% of Nb instead of 5 wt.% of V. Samples of both alloys were prepared by melting them in an arc furnace under an inert atmosphere, heat-treated at high temperatures for 12 h and plastic deformed using swage forging. Finally, these samples were solution heat-treated at temperatures above the β-transus followed by cooling at different rates using water quenching, furnace cooling and a modified Jominy end quench test. Characterization was performed by measuring Vickers hardness, X-ray diffraction, and light optical, scanning electron and transmission electron microscopy. The results obtained indicate that metastable β phase can be retained when the cooling rate is higher than 21 °C/s for both alloys. At lower cooling rates, α phase precipitation was observed, but it appeared to be less evident in the Nb-modified Ti-5553, suggesting that the replacement of V with Nb increased the hardenability of the alloy. - Highlights: • Hardenability of Ti alloys are assessed using a modified Jominy end quench test. • Ti-5553 and Nb-modified Ti-5553 are subjected to continuous cooling experiments. • β phase decomposition kinetics is reduced by replacing V with Nb in Ti-5553. • Nb-modified Ti-5553 features improved hardenability. • Replacement of V with Nb causes the

  17. Accelerated age hardening by plastic deformation in Al-Cu with minor additions of Si and Ge

    International Nuclear Information System (INIS)

    Victoria Castro Riglos, M.; Taquire de la Cruz, M.; Tolley, Alfredo

    2011-01-01

    An extremely fast hardening response with no reduction in peak hardness was obtained in Al-Cu with minor additions of Si and Ge by 8% plastic deformation before artificial aging. The mechanism for the accelerated hardening was determined by detailed characterization with transmission electron microscopy. Plastic deformation was found to enhance the nucleation rate of Si-Ge precipitates, resulting in a higher volume density. Such precipitates catalyzed the formation of θ' precipitates that are responsible for hardening.

  18. Thermal hardening of saturated clays. Application to underground storage of radioactive wastes

    International Nuclear Information System (INIS)

    Picard, Jean-Marc

    1994-01-01

    Saturated clays submitted to constant mechanical loading and slow temperature increase frequently undergo irreversible contractions. This phenomena is described here by means of a change of plastic limits induced by temperature only, called thermal hardening. Constitutive laws adapted to this kind of plastic behaviour can be formulated within a general framework that satisfies thermodynamical principles. It shows that this coupling results from the presence of a latent heat during the isothermal hardening of plastic limits. A thermomechanical extension of Cam Clay model is then proposed and used in the analysis of laboratory thermomechanical tests performed on clay materials. Making use of tests already published, we show the adequacy of the concept of thermal hardening for clay behaviour. Some clay from deep geological formation considered for the disposal of radioactive waste exhibit thermal hardening in laboratory tests. The consequences for the underground storage facilities during the thermal loading created by the waste are investigated by means of in situ tests as well as numerical computation. The measurement around a heating probe buried in the clay mass demonstrate the significance of thermo-hydro-mechanical couplings. An accurate understanding of in situ measurements is achieved by means of numerical modeling in which the interaction between the various loading of the tests (excavation, pore pressure seepage, and heating) is carefully taken into account. Thermal hardening of the clay appears to be of little influence in these in situ tests. On the other hand, the magnitude of thermo-hydro-mechanical couplings observed in situ are higher than might have been expected from laboratory tests. A more accurate prediction is obtained if one takes into account the more stiffer behaviour of clays when they are subjected to small deformations. (authors)

  19. Hardening of alloys in glow discharge with the use of pulsed electric current

    International Nuclear Information System (INIS)

    Shipko, M.N.; Pomel'nikova, A.S.; Solunin, A.M.; Solunin, M.A.

    2002-01-01

    The effect of ex/ternal pulsed electric field on the thickness of a hardened surface layer of a Nd-Fe-B system alloy during chemical heat treatment in a glow discharge is studied. The relationship is established between the hardened layer thickness and the frequency of external electric field which is verified by derived equations for the relation between electron energy and pulsed electric field frequency [ru

  20. Epoxy modified bitumen : Chemical hardening and its interpretation

    NARCIS (Netherlands)

    Apostolidis, P.; Pipintakos, G.; van de Ven, M.F.C.; Liu, X.; Erkens, Sandra; Scarpas, Athanasios

    2018-01-01

    Epoxy modified bitumen (EMB) is a promising technology for long lasting paving materials ensuring higher resistance to rutting, oxygen- and moisture-induced damage. In this paper, an analysis of the chemical reactions that take place during the chemical hardening process (curing) of epoxy modified

  1. Effect of the bainitic and martensitic microstructures on the hardening and embrittlement under neutron irradiation of a reactor pressure vessel steel

    Energy Technology Data Exchange (ETDEWEB)

    Marini, B., E-mail: bernard.marini@cea.fr [Commissariat à l' Energie Atomique et aux Energies Alternatives, DEN/DANS/DMN/SRMA, F-91191 Gif-sur Yvette (France); Averty, X. [Commissariat à l' Energie Atomique et aux Energies Alternatives, DEN/DANS/DMN/SEMI (now DEN/DANS/DM2S/SEMT), F-91191 Gif-sur Yvette (France); Wident, P.; Forget, P.; Barcelo, F. [Commissariat à l' Energie Atomique et aux Energies Alternatives, DEN/DANS/DMN/SRMA, F-91191 Gif-sur Yvette (France)

    2015-10-15

    The hardening and the embrittlement under neutron irradiation of an A508 type RPV steel considering three different microstructures (bainite, bainite-martensite and martensite)have been investigated These microstructures were obtained by quenching after autenitization at 1100 °C. The irradiation induced hardening appears to depend on microstructure and is correlated to the yield stress before irradiation. The irradiation induced embrittlement shows a more complex dependence. Martensite bearing microstructures are more sensitive to non hardening embrittlement than pure bainite. This enhanced sensitivity is associated with the development of intergranular brittle facture after irradiation; the pure martensite being more affected than the bainite-martensite. It is of interest to note that this mixed microstructure appears to be more embrittled than the pure bainitic or martensitic phases in terms of temperature transition shift. This behaviour which could emerge from the synergy of the embrittlement mechanisms of the two phases needs further investigations. However, the role of microstructure on brittle intergranular fracture development appears to be qualitatively similar under neutron irradiation and thermal ageing.

  2. The maraging steel corrosion properties with hardening of different kinds after double aging

    Directory of Open Access Journals (Sweden)

    L. V. Tarasenko

    2014-01-01

    Full Text Available The paper proposes to use high-strength corrosion-resistant maraging steels, which were developed for aircraft industry instead of carbon steel with coating to improve operation properties of the forcemeasuring resilient member in electronic strain-gauge balance.It examines the possibility to apply the martensitic-aging steels of Fe-Cr-Ni-Mo-Ti (ЭП678 and Fe-Cr-Ni-Mo-Cu-Nb (ЭП817 alloying systems. It was shown, that a traditional heat strain-hardening treatment including hardening and overageing of this steels provides combination of durability viscosity and corrosion- resistance, but at the same time it increases nonelastic effects and lowers the limit of elasticity because of reversing austenite formation. In this connection, it was proposed to use hardening with double aging i.e. main and low-temperature aging with no austenite formation as heat strainhardening treatment of steels for force-measuring resilient member. The goal of this work was to study the influence of double aging on the structure and properties of ЭП678 (06Х14Н6Д2МБТ and ЭП817 (03Х111Н10М2Т steels.The modes of double aging for ЭП817 steel were conformed to 4500С + 400 0С and 475 0С+ 400 0С, for ЭП678 steel – 530 0С + 500 0С. The structure and properties of hardened steels after main and double aging were compared.Metallographic analysis of samples after electrolytic etching was conducted with Leitz Metallovert microscope while the CamScan 4DV raster electronic microscope was used for Microroentgen-spectral analysis. The quantity of austenite was controlled with computerized setting DRON-4, the hardness was measured with ТК-2М instrument, corrosion-resistance was estimated with polarized curves, which were taken using a П-5848 potentiostat.The conducted research has shown, that double aging causes the additional hardening of steels due to disintegration of martensite and formation of dispersed Cu – corpuscles in ЭП817 steel and of Ni3Ti

  3. Effect of Fibers and Filler Types on Fresh and Hardened Properties of Self-Compacting Concrete

    Directory of Open Access Journals (Sweden)

    Saeed K. Rejeb* , Majid Kh . N. Ayad A. M.

    2014-04-01

    Full Text Available This paper deals with studying the fresh and hardened properties of self-compacting concrete, by using three types of filler (silica fume, clinker powder & lime stone powder, and two types of fibers (steel & glass fibers with volume fractions of (0.5% and (0.1% respectively. For each type of fillers, the fresh properties are measured by using Slump test, J- ring and V- funnel, while hardened properties include the compressive strength, splitting tensile strength and flexural strength. The results show that adding fibers to the self-compacting concrete (SCC well reduces the workability and improves the hardened properties. Also, the study concluded that better workability is obtained by using (lime stone, silica fume and clinker powder as fillers, respectively. While the higher hardened properties are gained by using silica fume were rather than those of other types of fillers 

  4. Optimization of resistively hardened latches

    International Nuclear Information System (INIS)

    Gagne, G.; Savaria, Y.

    1990-01-01

    The design of digital circuits tolerant to single-event upsets is considered. The results of a study are presented on which an analytical model was used to predict the behavior of a standard resistively hardened latch. It is shown that a worst case analysis for all possible single-event upset situations (on the latch or in the logic) can be derived from studying the effects of a transient disturbed write cycle. The existence of an intrinsic minimum write period to tolerate a transient of a given duration is also demonstrated

  5. Multiple regression analysis of Jominy hardenability data for boron treated steels

    International Nuclear Information System (INIS)

    Komenda, J.; Sandstroem, R.; Tukiainen, M.

    1997-01-01

    The relations between chemical composition and their hardenability of boron treated steels have been investigated using a multiple regression analysis method. A linear model of regression was chosen. The free boron content that is effective for the hardenability was calculated using a model proposed by Jansson. The regression analysis for 1261 steel heats provided equations that were statistically significant at the 95% level. All heats met the specification according to the nordic countries producers classification. The variation in chemical composition explained typically 80 to 90% of the variation in the hardenability. In the regression analysis elements which did not significantly contribute to the calculated hardness according to the F test were eliminated. Carbon, silicon, manganese, phosphorus and chromium were of importance at all Jominy distances, nickel, vanadium, boron and nitrogen at distances above 6 mm. After the regression analysis it was demonstrated that very few outliers were present in the data set, i.e. data points outside four times the standard deviation. The model has successfully been used in industrial practice replacing some of the necessary Jominy tests. (orig.)

  6. Effect of aging hardening on in situ synthesis magnesium matrix composites

    International Nuclear Information System (INIS)

    Zhang Xiuqing; Liao Lihua; Ma Naiheng; Wang Haowei

    2006-01-01

    Magnesium matrix composites reinforced with TiC particulates was synthesized using in situ synthesis technique. The result of XRD revealed the presence of TiC in precursor blocks and TiC/AZ91 composites. Effect of aging hardening on the composites was described using Brinell hardness measurements and scanning electron microscopy (SEM). The results revealed that the aging hardening peak of TiC/AZ91 composite appeared earlier comparatively with that of AZ91 magnesium alloy. And the appearance of aging hardening peak was earlier under the higher aging temperature such as 200 deg. C. The precipitating behavior of Mg 17 Al 12 phase in AZ91 alloy and TiC/AZ91 composites was described. Little discontinuous was discovered in the composites, and the amount of continuous precipitate in the composite matrix is smaller comparatively to that of AZ91 alloy. These results were analyzed with the fine grain size, much more interface between TiC and magnesium and high-density dislocation in magnesium matrix, which was contributed to the addition of TiC particulates

  7. NEW APPROACH FOR TECHNOLOGY OF VOLUMETRIC – SUPERFICIAL HARDENING OF GEAR DETAILS OF THE BACK AXLE OF MOBILE MACHINES

    Directory of Open Access Journals (Sweden)

    A. I. Mihluk

    2010-01-01

    Full Text Available The new approach for technology of volumetric – superficial hardening of gear details of the back axle made of steel lowered harden ability is offered. This approach consisting in formation of intense – hardened condition on all surface of a detail.

  8. Microstructural and Mechanical Study of Press Hardening of Thick Boron Steel Sheet

    Science.gov (United States)

    Pujante, J.; Garcia-Llamas, E.; Golling, S.; Casellas, D.

    2017-09-01

    Press hardening has become a staple in the production of automotive safety components, due to the combination of high mechanical properties and form complexity it offers. However, the use of press hardened components has not spread to the truck industry despite the advantages it confers, namely affordable weight reduction without the use of exotic materials, would be extremely attractive for this sector. The main reason for this is that application of press hardened components in trucks implies adapting the process to the manufacture of thick sheet metal. This introduces an additional layer of complexity, mainly due to the thermal gradients inside the material resulting in though-thickness differences in austenitization and cooling, potentially resulting in complex microstructure and gradient of mechanical properties. This work presents a preliminary study on the press hardening of thick boron steel sheet. First of all, the evolution of the sheet metal during austenitization is studied by means of dilatometry tests and by analysing the effect of furnace dwell time on grain size. Afterwards, material cooled using different cooling strategies, and therefore different effective cooling rates, is studied in terms of microstructure and mechanical properties. Initial results from finite element simulation are compared to experimental results, focusing on the phase composition in through thickness direction. Results show that industrial-equivalent cooling conditions do not lead to gradient microstructures, even in extreme scenarios involving asymmetrical cooling.

  9. Characterization and Strain-Hardening Behavior of Friction Stir-Welded Ferritic Stainless Steel

    Science.gov (United States)

    Sharma, Gaurav; Dwivedi, Dheerendra Kumar; Jain, Pramod Kumar

    2017-12-01

    In this study, friction stir-welded joint of 3-mm-thick plates of 409 ferritic stainless steel (FSS) was characterized in light of microstructure, x-ray diffraction analysis, hardness, tensile strength, ductility, corrosion and work hardening properties. The FSW joint made of ferritic stainless steel comprises of three distinct regions including the base metal. In stir zone highly refined ferrite grains with martensite and some carbide precipitates at the grain boundaries were observed. X-ray diffraction analysis also revealed precipitation of Cr23C6 and martensite formation in heat-affected zone and stir zone. In tensile testing of the transverse weld samples, the failure eventuated within the gauge length of the specimen from the base metal region having tensile properties overmatched to the as-received base metal. The tensile strength and elongation of the longitudinal (all weld) sample were found to be 1014 MPa and 9.47%, respectively. However, in potentiodynamic polarization test, the corrosion current density of the stir zone was highest among all the three zones. The strain-hardening exponent for base metal, transverse and longitudinal (all weld) weld samples was calculated using various equations. Both the transverse and longitudinal weld samples exhibited higher strain-hardening exponents as compared to the as-received base metal. In Kocks-Mecking plots for the base metal and weld samples at least two stages of strain hardening were observed.

  10. Formation and evolution of the hardening precipitates in a Mg-Y-Nd alloy

    International Nuclear Information System (INIS)

    Barucca, G.; Ferragut, R.; Fiori, F.; Lussana, D.; Mengucci, P.; Moia, F.; Riontino, G.

    2011-01-01

    The formation and evolution of hardening precipitates in a Mg-Y-Nd (WE43) alloy during artificial ageing at 150 and 210 deg. C is followed by small angle X-ray scattering (SAXS) measurements, Vickers microhardness tests and transmission electron microscopy (TEM) observations. A quantitative description of the alloy studied during the early and advanced stages of the precipitation sequence is presented. In situ SAXS evolution at 210 deg. C of the size, volume fraction and number density of the subnanometer and nanometer particles that evolve in the β'' phase was obtained. TEM and microhardness results indicate that the hardening mechanism is based on β'' transformation of pre-precipitates and their growth at 150 deg. C, while at 210 deg. C hardening is mainly associated with β'' → β' transformation.

  11. Rotavirus specific maternal antibodies and immune response to RV3-BB neonatal rotavirus vaccine in New Zealand

    OpenAIRE

    Chen, Mee-Yew; Kirkwood, Carl D.; Bines, Julie; Cowley, Daniel; Pavlic, Daniel; Lee, Katherine J.; Orsini, Francesca; Watts, Emma; Barnes, Graeme; Danchin, Margaret

    2017-01-01

    Background: Maternal antibodies, acquired passively via placenta and/or breast milk, may contribute to the reduced efficacy of oral rotavirus vaccines observed in children in developing countries. This study aimed to investigate the effect of rotavirus specific maternal antibodies on the serum IgA response or stool excretion of vaccine virus after any dose of an oral rotavirus vaccine, RV3-BB, in parallel to a Phase IIa clinical trial conducted at Dunedin Hospital, New Zealand. At the time o...

  12. Group precipitation and age hardening of nanostructured Fe-based alloys with ultra-high strengths

    Science.gov (United States)

    Jiao, Z. B.; Luan, J. H.; Miller, M. K.; Yu, C. Y.; Liu, C. T.

    2016-01-01

    The precipitation of nanoparticles plays a key role in determining the properties of many structural materials, and the understanding of their formation and stabilization mechanisms has been a long standing interest in the material field. However, the critical issues involving the group precipitation of various nanoparticles and their cooperative hardening mechanism remain elusive in the newly discovered Fe-based alloys with nanostructures. Here we quantitatively elucidate the nucleation mechanism, evolution kinetics and hardening effects of the group-precipitated nanoparticles in the Fe-Cu-Ni-Al-based alloys by atom probe tomography together with both first-principles and thermodynamic calculations. Our results provide the compelling evidence for two interesting but complex group precipitation pathways of nanoparticles, i.e., the Cu-rich and NiAl-based precipitations. The co-existence of the two precipitation pathways plays a key role in age hardening kinetics and ultimately enhances the hardening response, as compared to the single particle type of strengthening, therefore providing an effective new approach for strengthening materials for structural applications. PMID:26892834

  13. Radiation-Hardened Memristor-based Memory for Extreme Environments, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA space exploration missions require radiation-hardened memory technologies that can survive and operate over a wide temperature range. Memristors...

  14. Der Peipussee/Peipsi järv Fischereiche Ostgrenze der EU / Arne von Maydell

    Index Scriptorium Estoniae

    Maydell, Arne von

    2012-01-01

    Mööda Peipsi järve kulgeb alates 1. maist 2004 Euroopa Liidu ja Venemaa vaheline piir. Suur siseeveekogu on üks suuremaid järvi Euroopas. Järv on väga kalarikas. Nii vene kui eesti kultuuris on Peipsi järvel oma koht

  15. Mycobacterium tuberculosis Rv3402c enhances mycobacterial survival within macrophages and modulates the host pro-inflammatory cytokines production via NF-kappa B/ERK/p38 signaling.

    Directory of Open Access Journals (Sweden)

    Wu Li

    Full Text Available Intracellular survival plays a central role in the pathogenesis of Mycobacterium tuberculosis, a process which depends on an array of virulence factors to colonize and replicate within the host. The M. tuberculosis iron regulated open reading frame (ORF rv3402c, encoding a conserved hypothetical protein, was shown to be up-regulated upon infection in both human and mice macrophages. To explore the function of this ORF, we heterologously expressed the rv3402c gene in the non-pathogenic fast-growing Mycobacterium smegmatis strain, and demonstrated that Rv3402c, a cell envelope-associated protein, was able to enhance the intracellular survival of recombinant M. smegmatis. Enhanced growth was not found to be the result of an increased resistance to intracellular stresses, as growth of the Rv3402c expressing strain was unaffected by iron depletion, H2O2 exposure, or acidic conditions. Colonization of macrophages by M. smegmatis expressing Rv3402c was associated with substantial cell death and significantly greater amount of TNF-α and IL-1β compared with controls. Rv3402c-induced TNF-α and IL-1β production was found to be mediated by NF-κB, ERK and p38 pathway in macrophages. In summary, our study suggests that Rv3402c delivered in a live M. smegmatis vehicle can modify the cytokines profile of macrophage, promote host cell death and enhance the persistence of mycobacterium within host cells.

  16. Design optimization of radiation-hardened CMOS integrated circuits

    International Nuclear Information System (INIS)

    1975-01-01

    Ionizing-radiation-induced threshold voltage shifts in CMOS integrated circuits will drastically degrade circuit performance unless the design parameters related to the fabrication process are properly chosen. To formulate an approach to CMOS design optimization, experimentally observed analytical relationships showing strong dependences between threshold voltage shifts and silicon dioxide thickness are utilized. These measurements were made using radiation-hardened aluminum-gate CMOS inverter circuits and have been corroborated by independent data taken from MOS capacitor structures. Knowledge of these relationships allows one to define ranges of acceptable CMOS design parameters based upon radiation-hardening capabilities and post-irradiation performance specifications. Furthermore, they permit actual design optimization of CMOS integrated circuits which results in optimum pre- and post-irradiation performance with respect to speed, noise margins, and quiescent power consumption. Theoretical and experimental results of these procedures, the applications of which can mean the difference between failure and success of a CMOS integrated circuit in a radiation environment, are presented

  17. work hardening, recovery and recrystallization of alloys containing dispersed precipitates

    International Nuclear Information System (INIS)

    Padilha, A.F.

    1989-01-01

    This paper reviews the work hardening, recovery and recrystallization mechanisms in alloys containing dispersed precipitates. In the section on work hardening, the influence od spacing, particle size and shape on the density and distribution of dislocations have been discussed. They represent a large part of the energy stored in the material following drformation, which in turn is driving force for recrystallization. Next, the role of precipitates on recovery, on the formation and the growth of recrystallized regions has been discussed in detail. The competition between recovery and recrystallization and recrystallization of supersaturated solid solutions have also been mentioned. Finally, the technological relevance of the aspects treated in this paper has been discussed. (author) [pt

  18. Radiation Effects and Component Hardening testing program at the Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Draper, J.V.; Weil, B.S.; Chesser, J.B.

    1993-01-01

    This paper describes Phase II of the Radiation Effects and Component Hardening (REACH) testing program, performed as part of the joint collaborative agreement between the United States Department of Energy (USDOE) and the Power Reactor and Nuclear Fuel Development Corporation (PNC) of Japan, Components and materials were submitted to 10 5 R/hr gamma radiation fields for 10,000 hr, producing accumulated doses of 10 9 R; most performed as expected

  19. Experimental drying shrinkage of hardened cement pastes as a function of relative humidity

    DEFF Research Database (Denmark)

    Hansen, Kurt Kielsgaard; Baroghel, V.B.

    1996-01-01

    The results of an experimental study concerning drying shrinkage measured as a function of relative humidity on thin specimens of mature hardened cement pastes are presented. The results obtained at two laboratories are compared.......The results of an experimental study concerning drying shrinkage measured as a function of relative humidity on thin specimens of mature hardened cement pastes are presented. The results obtained at two laboratories are compared....

  20. Work hardening and mechanical equation of state in some metals in monotonic loading

    International Nuclear Information System (INIS)

    Wire, G.L.; Ellis, F.V.; Li, C.Y.

    The work hardening coefficients of Type 316 stainless steel, niobium, and 1100 aluminum alloy are measured in tensile tests. It is demonstrated experimentally that in the measured stress, plastic strain rate, and temperature range the work hardening coefficient depends only on stress and plastic strain rate. The significance of the experimental results is discussed in terms of the concept of the mechanical equation of state for plastic deformation. 13 figures

  1. Observation of a New Mechanism Balancing Hardening and Softening in Metals

    DEFF Research Database (Denmark)

    Yu, Tianbo; Hansen, Niels; Huang, Xiaoxu

    2014-01-01

    Plastic deformation of metals refines the microstructure and increases the strength through work hardening, but this effect of deformation is counterbalanced by dynamic recovery. After large strain, the microstructure typically shows a lamellar morphology, with finely spaced lamellar boundaries...... connected by triple junctions. Here, we report that mechanically assisted triple junction motion is an important contributor to dynamic recovery, leading to an almost steady state. Triple junction motion replaces two boundaries by one, while maintaining the structural morphology. The observation...... rationalizes both a decreasing work hardening rate and the approach to a dynamic equilibrium of structural refinement at large strains....

  2. Calculation of calcium diffusion coefficient of cement hardenings using minute pore data

    International Nuclear Information System (INIS)

    Hitomi, Takashi; Takeda, Nobufumi; Iriya, Keishiro

    2009-01-01

    This report describes the calculations of the diffusion coefficient of the Ca ion of cement hardenings using minute pore data. The observed hardenings were ordinary Portland cement (OPC), low-heat Portland cement with fly ash (LPC+FA) and highly fly ash containing silica fume cement (HFSC). The samples were cured in the standard and artificially leached by accelerated test. Minute pore datas of the cement hardenings were acquired with image processing of internal structural information obtained from high resolution X-ray computed tomography observations. Upon analysis, several voxels are combined into one bigger voxel, the diffusion coefficient of the voxels were determined in proportion to the number of voxels which were included in. The results reveal that the change in the calcium diffusion coefficient of OPC due to leaching was large, but the LPC+FA and HFSC cements exhibited even greater changes than OPC. It is suggested that the diffusion coefficients are proportional to the Ca/Si ratio of the samples. (author)

  3. Non-destructive screening method for radiation hardened performance of large scale integration

    International Nuclear Information System (INIS)

    Zhou Dong; Xi Shanbin; Guo Qi; Ren Diyuan; Li Yudong; Sun Jing; Wen Lin

    2013-01-01

    The space radiation environment could induce radiation damage on the electronic devices. As the performance of commercial devices is generally superior to that of radiation hardened devices, it is necessary to screen out the devices with good radiation hardened performance from the commercial devices and applying these devices to space systems could improve the reliability of the systems. Combining the mathematical regression analysis with the different physical stressing experiments, we investigated the non-destructive screening method for radiation hardened performance of the integrated circuit. The relationship between the change of typical parameters and the radiation performance of the circuit was discussed. The irradiation-sensitive parameters were confirmed. The pluralistic linear regression equation toward the prediction of the radiation performance was established. Finally, the regression equations under stress conditions were verified by practical irradiation. The results show that the reliability and accuracy of the non-destructive screening method can be elevated by combining the mathematical regression analysis with the practical stressing experiment. (authors)

  4. SEGR- and SEB-hardened structure with DSPSOI in power MOSFETs

    Science.gov (United States)

    Tang, Zhaohuan; Fu, Xinghua; Yang, Fashun; Tan, Kaizhou; Ma, Kui; Wu, Xue; Lin, Jiexing

    2017-12-01

    Single event irradiation-hardened power MOSFET is the most important device for DC/DC converter in space environment application. Single event gate rupture (SEGR) and single event burnout (SEB), which will degrade the running safety and reliability of spacecraft, are the two typical failure modes in power MOSFETs. In this paper, based on recombination mechanism of interface between oxide and silicon, a novel hardened power MOSFETs structure for SEGR and SEB is proposed. The structure comprises double stagger partial silicon-on-insulator (DSPSOI) layers. Results show that the safety operation area (SOA) of a 130 V N-channel power MOSFET in single event irradiation environment is enhanced by up to 50% when the linear-energy-transfer value of heavy ion is a constant of 98 MeV·cm2/mg in the whole incident track, and the other parameters are almost maintained at the same value. Thus this novel structure can be widely used in designing single event irradiation-hardened power MOSFETs. Project supported by the National Natural Science Foundation of China (No. 61464002), the Grand Science and Technology Special Project in Guizhou Province of China (No. [2015]6006), and the Ministry of Education Open Foundation for Semiconductor Power Device Reliability (No. 010201).

  5. The shrinkage of hardening cement paste and mortar

    NARCIS (Netherlands)

    Haas, de G.D.; Kreijger, P.C.; Niël, E.M.M.G.; Slagter, J.C.; Stein, H.N.; Theissing, E.M.; Wallendael, van M.

    1975-01-01

    This paper is an abstract from the report of the commission B10: "The influence of the shrinkage of cement on the shrink-age of concrete", of the Netherlands Committee for Concrete Research. Measurements of pulse velocity, volume shrinkage and heat of hydration on hardening portland cement support

  6. Microstructure-property relationships and constitutive response of plastically graded case hardened steels

    Science.gov (United States)

    Klecka, Michael A.

    Case hardened materials, popularly used in many demanding engineering applications such as bearings, gears, and wear/impact surfaces, have high surface hardness and a gradient in material properties (hardness, yield strength, etc.) as a function of depth; therefore, they behave as plastically graded materials. In the current study, two different commercially available case carburized steels along with two through hardened steels are characterized to obtain relationships among the volume fraction of subsurface carbides, indentation hardness, elastic modulus, and yield strength as a function of depth. A variety of methods including microindentation, nanoindentation, ultrasonic measurements, compression testing, rule of mixtures, and upper and lower bound models are used to determine the relationships for elastic modulus and compare the experimental results with model predictions. In addition, the morphology, composition, and properties of the carbide particles are also determined. The gradient in hardness with depth in graded materials is commonly determined using microindentation on the cross-section of the material which contains the gradation in microstructure or composition. In the current study, a novel method is proposed to predict the hardness gradient profile using solely surface indentations at a range of loads. The method does not require the graded material to be sectioned, and has practical utility in the surface heat-treatment industry. For a material with a decreasing gradient in hardness, higher indent loads result in a lower measured hardness due to the influence of the softer subsurface layers. A power-law model is presented which relates the measured surface indentation hardness under increasing load to the subsurface gradient in hardness. A coordinated experimental and numerical study is presented to extract the constitutive response of graded materials, utilizing relationships between hardness, plastic deformation, and strain hardening response

  7. Investigation on the effect of chemical composition on the texture and bake hardening I F steels

    International Nuclear Information System (INIS)

    Kariman, M.; Motaghi, A.; Raygan, Sh.; Habibi Parsa, M.; Nili Ahmadabadi, M.

    2008-01-01

    Interstitial free steels have good formability and also excellent deep draw ability. These features make them one of the applicable materials in automotive industry. Chemical composition and thermomechanical treatment used to process these steels have important role in final properties of them. In this study, the effect of chemical composition on texture, anisotropic properties and bake harden ability of these steels were investigated. The results showed that contribution of vanadium as a weak carbonitride former element with titanium as strong carbonitride former could change the texture of steels. Replacing titanium with vanadium caused harmful effect on mechanical properties. In this research deep drawing properties of five steels were compared based on I {111} / I{001} and I {111} / I{110} parameters. The results of bake harden ability test showed that there were critical limits for vanadium volume fractions above which bake harden properties was improved. It was shown that the bake harden properties of Nb-steels were better than that of Ti-steels. This was due to the better solution of Nb(C,N) compared to Ti(C,N). Addition of vanadium to Ti-steels may improve bake harden properties of I F steels

  8. MICROSTRUCTURAL FEATURES EVALUATION OF AGE-HARDENED A 226 CAST ALLOY BY IMAGE ANALYSIS

    Directory of Open Access Journals (Sweden)

    Lenka Kuchariková

    2018-01-01

    Full Text Available Age-hardening provides one of the most widely used mechanisms for the strengthening of aluminum alloys. The age-hardening involves three steps: solution treatment, quenching and aging. The temperature of solution treatment and aging is very important in order to reach desired properties of castings. The optimum temperature of solution treatment and aging led to formation microstructural features in form which does not lead to decreasing properties, but increasing ones. The major microstructural features in A 226 cast alloys which are responsible for increasing properties are: eutectic Si particles, Cu-rich phases, Fe-rich phases and porosity. The increase of properties depends on morphology, size and volume of microstructural features. In order to assess age-hardening influence on microstructural features in A226 cast alloys were used as possibilities of evaluation by means of image analysis. Quantitative analysis decelerate changes in microstructure includes the spheroidization and coarsening of eutectic silicon, gradual disintegration, shortening and thinning of Fe-rich intermetallic phases, the dissolution of precipitates and the precipitation of finer hardening phase (Al2Cu further increase in the hardness and tensile strength in the alloy. Changes of mechanical properties were measured in line with STN EN ISO.

  9. Influence of Cultivar on the Postharvest Hardening of Trifoliate Yam (Dioscorea dumetorum Tubers

    Directory of Open Access Journals (Sweden)

    Christian Siadjeu

    2016-01-01

    Full Text Available The influence of cultivar on the postharvest hardening of Dioscorea dumetorum tubers was assessed. 32 cultivars of D. dumetorum tubers were planted in April 2014, harvested at physiological maturity, and stored under prevailing tropical ambient conditions (19–28°C, 60–85% RH for 0, 5, 14, 21, and 28 days. Samples were evaluated for cooked hardness. Results showed that one cultivar, Ibo sweet 3, was not affected by the hardening phenomenon. The remaining 31 were all subject to the hardening phenomenon at different degree. Cooked hardness increased more rapidly in cultivars with many roots on the tuber surface compared to cultivars with few roots on the tuber surface. When both the characteristics flesh colour and number of roots on tuber surface were associated, cooked hardness in cultivars with yellow flesh and many roots increased more rapidly than in cultivars with white flesh and many roots, whereas cooked hardness in cultivars with yellow flesh and few roots increased more slowly than in cultivars with white flesh and few roots. Accessions collected in high altitude increased more rapidly compared to accessions collected in low altitude. The cultivar Ibo sweet 3 identified in this study could provide important information for breeding program of D. dumetorum against postharvest hardening phenomenon.

  10. METHYL JASMONATE AND STEM BENDING HARDENING AND INITIAL GROWTH OF Cordia trichotoma SEEDLINGS

    Directory of Open Access Journals (Sweden)

    Danielle Acco Cadorin

    2015-12-01

    Full Text Available The submission of seedlings to mechanical stimuli and plant growth regulator promote their hardening and can be included in the routine of nurseries, favoring the survival and initial growth in the field. The study aimed to evaluate the effects of applying methyl jasmonate and stem bending in hardening and initial growth of Cordia trichotoma seedlings. Seedlings were subjected to 20 stem bending daily for 4 weeks; 20 stem bending daily for 8 weeks; 50 µmol.L-1 of methyl jasmonate applied weekly for 4 weeks; 50 µmol.L-1 of methyl jasmonate applied weekly for 8 weeks and the control treatment. The design was a completely randomized, with five repetitions of the fourteen seedlings. Seedlings submitted to hardening treatments showed less increment in height, greater increment in stem diameter and less value for strength index. Seedlings of control treatment had greater loss of root tissue electrolytes and less potential for root regeneration. In the field, 180 days after planting, seedlings submitted to eight weeks of stem bending and eight methyl jasmonate applications showed greater increment in height and stem diameter. The results indicate that both stem bending such as methyl jasmonate application for eight weeks are effective in promoting hardening and improve the starting performance in field of Cordia trichotoma seedlings.

  11. Assessment of right ventricular longitudinal strain by 2D speckle tracking imaging compared with RV function and hemodynamics in pulmonary hypertension.

    Science.gov (United States)

    Li, Yidan; Wang, Yidan; Meng, Xiangli; Zhu, Weiwei; Lu, Xiuzhang

    2017-11-01

    The right ventricular longitudinal strain (RVLS) of pulmonary hypertension (PH) patients and its relationship with RV function parameters measured by echocardiography and hemodynamic parameters measured by right heart catheterization was investigated. According to the WHO functional class (FC), 66 PH patients were divided into FC I/II (group 1) and III/IV (group 2). RV function parameters were measured by echocardiographic examinations. Hemodynamic parameters were obtained by right heart catheterization. Patients in group 2 had higher systolic pulmonary artery pressure (sPAP; P good sensitivity and specificity. Evidence has shown that RVLS measurement can provide the much-needed and reliable information on RV function and hemodynamics. Therefore, this qualifies as a patient-friendly approach for the clinical management of PH patients.

  12. Configurable Radiation Hardened High Speed Isolated Interface ASIC, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — NVE Corporation will design and build an innovative, low cost, flexible, configurable, radiation hardened, galvanically isolated, interface ASIC chip set that will...

  13. Determining the water-cement ratio, cement content, water content and degree of hydration of hardened cement paste: Method development and validation on paste samples

    International Nuclear Information System (INIS)

    Wong, H.S.; Buenfeld, N.R.

    2009-01-01

    We propose a new method to estimate the initial cement content, water content and free water/cement ratio (w/c) of hardened cement-based materials made with Portland cements that have unknown mixture proportions and degree of hydration. This method first quantifies the composition of the hardened cement paste, i.e. the volumetric fractions of capillary pores, hydration products and unreacted cement, using high-resolution field emission scanning electron microscopy (FE-SEM) in the backscattered electron (BSE) mode and image analysis. From the obtained data and the volumetric increase of solids during cement hydration, we compute the initial free water content and cement content, hence the free w/c ratio. The same method can also be used to calculate the degree of hydration. The proposed method has the advantage that it is quantitative and does not require comparison with calibration graphs or reference samples made with the same materials and cured to the same degree of hydration as the tested sample. This paper reports the development, assumptions and limitations of the proposed method, and preliminary results from Portland cement pastes with a range of w/c ratios (0.25-0.50) and curing ages (3-90 days). We also discuss the extension of the technique to mortars and concretes, and samples made with blended cements.

  14. Mechanical properties of metastable austenitic steels, strengthened by hydroextruction and structural hardening

    International Nuclear Information System (INIS)

    Beresnev, B.I.; Georgieva, I.Ya.; Eshchenko, R.N.; Teplov, V.A.

    1981-01-01

    Different regimes of complex strengthening of steels of Fe-Ni-Mo-C system by phase hardening and plastic deformation by hydroextrusion are investigated. It is stated that the degree of strengthening depends on consequence of strengthening operations. Plastic deformation by hydroextrusion of steels stre--ngthened by phase hardening ensures increase of strength (Δσsub(0.2)=500 MPa) at high plasticity (delta=25%). Maximal values of strength properties can be achieved if hydroextrusion is conducted before and after thansverse α→γ-transformation [ru

  15. Formation and evolution of the hardening precipitates in a Mg-Y-Nd alloy

    Energy Technology Data Exchange (ETDEWEB)

    Barucca, G. [Dipartimento di Fisica e Ingegneria dei Materiali e del Territorio, Universita Politecnica delle Marche, Via Brecce Bianche, I-60131 Ancona (Italy); Ferragut, R. [Dipartimento di Fisica, LNESS and CNISM, Politecnico di Milano, Via Anzani 42, I-22100 Como (Italy); Fiori, F. [Dipartimento SAIFET, Sezione di Scienze Fisiche, Universita Politecnica delle Marche, Via Brecce Bianche, I-60131 Ancona (Italy); Lussana, D. [Dipartimento di Chimica IFM and NIS Centre, Universita di Torino, Via P. Giuria 9, I-10125 Torino (Italy); Mengucci, P., E-mail: p.mengucci@univpm.it [Dipartimento di Fisica e Ingegneria dei Materiali e del Territorio, Universita Politecnica delle Marche, Via Brecce Bianche, I-60131 Ancona (Italy); Moia, F. [Dipartimento di Fisica, LNESS and CNISM, Politecnico di Milano, Via Anzani 42, I-22100 Como (Italy); Riontino, G. [Dipartimento di Chimica IFM and NIS Centre, Universita di Torino, Via P. Giuria 9, I-10125 Torino (Italy)

    2011-06-15

    The formation and evolution of hardening precipitates in a Mg-Y-Nd (WE43) alloy during artificial ageing at 150 and 210 deg. C is followed by small angle X-ray scattering (SAXS) measurements, Vickers microhardness tests and transmission electron microscopy (TEM) observations. A quantitative description of the alloy studied during the early and advanced stages of the precipitation sequence is presented. In situ SAXS evolution at 210 deg. C of the size, volume fraction and number density of the subnanometer and nanometer particles that evolve in the {beta}'' phase was obtained. TEM and microhardness results indicate that the hardening mechanism is based on {beta}'' transformation of pre-precipitates and their growth at 150 deg. C, while at 210 deg. C hardening is mainly associated with {beta}'' {yields} {beta}' transformation.

  16. Hardening by means of ionising radiation

    International Nuclear Information System (INIS)

    Spoor, H.; Demmler, K.

    1979-01-01

    The polymerisable ethylic unsaturated mixture can be hardened by means of electron irradiation and used as a corrosion preventive layer. The mixture mainly consists of at least a di-olefinic unsaturated polyester, partial esters of polycarbonic acids, in particular the monoester of dicarbonic acids, with a copolymerizable C-C double bond, and mono-olefine unsaturated hydrocarbons, for example vinyl aromatics. The coatings exhibit good adhesion to the substrate, in particular to metal, and good flexibility. (DG) [de

  17. A strain-hardening bi-power law for the nonlinear behaviour of biological soft tissues.

    Science.gov (United States)

    Nicolle, S; Vezin, P; Palierne, J-F

    2010-03-22

    Biological soft tissues exhibit a strongly nonlinear viscoelastic behaviour. Among parenchymous tissues, kidney and liver remain less studied than brain, and a first goal of this study is to report additional material properties of kidney and liver tissues in oscillatory shear and constant shear rate tests. Results show that the liver tissue is more compliant but more strain hardening than kidney. A wealth of multi-parameter mathematical models has been proposed for describing the mechanical behaviour of soft tissues. A second purpose of this work is to develop a new constitutive law capable of predicting our experimental data in the both linear and nonlinear viscoelastic regime with as few parameters as possible. We propose a nonlinear strain-hardening fractional derivative model in which six parameters allow fitting the viscoelastic behaviour of kidney and liver tissues for strains ranging from 0.01 to 1 and strain rates from 0.0151 s(-1) to 0.7s(-1). Copyright (c) 2009 Elsevier Ltd. All rights reserved.

  18. Low-cycle fatigue behaviors of pre-hardening Hadfield steel

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Chen [State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004 (China); Lv, Bo [College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004 (China); Wang, Fei [State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004 (China); Zhang, Fucheng, E-mail: zfc@ysu.edu.cn [State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004 (China); National Engineering Research Center for Equipment and Technology of Cold Strip Rolling, Yanshan University, Qinhuangdao 066004 (China)

    2017-05-17

    Low-cycle fatigue behaviors of the pre-hardening (PH) and the water-quenching (WQ) Hadfield steel were studied using optical microscopy, transmission electron microscopy, and electron backscatter diffraction technique. The effect of the PH treatment on low-cycle fatigue behavior of the Hadfield steel was analyzed through comparing the cyclic hardening/softening behaviors and the changing regulations of stress amplitude, internal stress, and effective stress at different total strain amplitudes. Results showed obvious differences in fatigue behaviors between the PH (with a cold rolling deformation degree of 40%) and the WQ Hadfield steels. Transient hardening followed by cyclic stability behavior occurred in the PH Hadfield steel under cyclic loading, whereas cyclic softening behavior was barely observed. The fatigue life of the PH Hadfield steel was higher than that of the WQ Hadfield steel at relatively low strain amplitudes, while a contrary result was obtained at relatively high strain amplitudes. At low strain amplitudes, the deformation twins induced in the PH Hadfield steel could enhance the multiplication and slip process of dislocations, which actually improved the deformation uniformity. The long-range motion of dislocations was intensified at high strain amplitudes. However, the dislocation motion was also blocked by twin boundaries. As a result, the interactions between dislocations and deformation twins enhanced, finally causing severe dislocation accumulation. These two effects of deformation twins on dislocation motion eventually resulted in different low-cycle fatigue behaviors of the PH Hadfield steel.

  19. "Deviance Proneness" and Adolescent Smoking 1980 versus 2001: Has There Been a "Hardening" of Adolescent Smoking?

    Science.gov (United States)

    Chassin, Laurie; Presson, Clark; Morgan-Lopez, Antonio; Sherman, Steven J.

    2007-01-01

    In a midwestern community sample, we tested for evidence of "hardening" of adolescent cigarette smoking between 1980 and 2001 by comparing adolescent smokers and nonsmokers at these two times on measures indicative of "deviance proneness" in Jessor and Jessor's [Jessor, R., & Jessor, S. L. (1977). "Problem behavior and psychosocial development: A…

  20. System Hardening Architecture for Safer Access to Critical Business ...

    African Journals Online (AJOL)

    System Hardening Architecture for Safer Access to Critical Business Data. ... and the threat is growing faster than the potential victims can deal with. ... in this architecture are applied to the host, application, operating system, user, and the ...

  1. Characterization and hardenability evaluation of gray cast iron used in the manufacture of diesel engine cylinder liners

    Directory of Open Access Journals (Sweden)

    Edgar L. Castellanos-Leal

    2017-09-01

    Full Text Available The increment of the mechanical properties (surface hardness of engine cylinder is one of the principal goals for foundry company, to increase the competitiveness of their products in the local and foreign market. This study focused on the characterization of the gray cast iron used in the production of engine cylinder liners and metallurgical parameters determination in the design of conventional quenching heat treatment. The characterization was performed by material hardenability evaluation using Grossmann method, and Jominy test; the austenitizing temperature and the severity of cooling medium to a proper hardening of material were selected. Results revealed that the excellent hardness value obtained is attributed to the suitable hardenability of the gray cast iron and adequate severity selection for hardening treatment.

  2. Low-temperature gaseous surface hardening of stainless steel: the current status

    DEFF Research Database (Denmark)

    Christiansen, Thomas; Somers, Marcel A. J.

    2009-01-01

    a hardened case at the surface, while maintaining the superior corrosion performance. This can be achieved by dissolving colossal amounts of nitrogen and/or carbon without forming nitrides and/or carbides, thus developing so-called expanded austenite. The present work gives an overview over results obtained...... on homogeneous expanded austenite and covers the crystallography for nitrogen- and carbon-stabilised expanded austenite, the solubility for nitrogen and carbon, the diffusion of these interstitials as well as the stability of expanded austenite with respect to nitride and carbide formation. Subsequently...

  3. Hardening XL. Induction technology with rotating crankshaft; Haerten XL. Induktionstechnik mit rotierender Kurbelwelle

    Energy Technology Data Exchange (ETDEWEB)

    Dappen, Stefan; Schibisch, Dirk M. [SMS Elotherm GmbH, Remscheid (Germany)

    2013-03-15

    Crankshafts are used in combustion engines, transforming the con rod's stroke into a rotary motion for driving the axle shaft. Along with this, torsional and flexural fatigue appears and demands a special heat treatment process. The induction hardening with a rotating crankshaft has mostly replaced competitive methods and provides the engine builders with a flexible production process for varying geometries, different hardening zones as well as increasing production rates. (orig.)

  4. Comparison of single and consecutive dual frequency induction surface hardening of gear wheels

    Science.gov (United States)

    Barglik, J.; Ducki, K.; Kukla, D.; Mizera, J.; Mrówka-Nowotnik, G.; Sieniawski, J.; Smalcerz, A.

    2018-05-01

    Mathematical modelling of single and consecutive dual - frequency induction surface hardening systems are presented and compared. The both models are solved by the 3D FEM-based professional software supported by a number of own numerical procedures. The methodology is illustrated with some examples of surface induction hardening of a gear wheel made of steel 41Cr4. The computations are in a good accordance with experiments provided on the laboratory stand.

  5. The ABC transporter Rv1272c of Mycobacterium tuberculosis enhances the import of long-chain fatty acids in Escherichia coli.

    Science.gov (United States)

    Martin, Audrey; Daniel, Jaiyanth

    2018-02-05

    Mycobacterium tuberculosis (Mtb), which causes tuberculosis, is capable of accumulating triacylglycerol (TAG) by utilizing fatty acids from host cells. ATP-binding cassette (ABC) transporters are involved in transport processes in all organisms. Among the classical ABC transporters in Mtb none have been implicated in fatty acid import. Since the transport of fatty acids from the host cell is important for dormancy-associated TAG synthesis in the pathogen, mycobacterial ABC transporter(s) could potentially be involved in this process. Based on sequence identities with a bacterial ABC transporter that mediates fatty acid import for TAG synthesis, we identified Rv1272c, a hitherto uncharacterized ABC-transporter in Mtb that also shows sequence identities with a plant ABC transporter involved in fatty acid transport. We expressed Rv1272c in E. coli and show that it enhances the import of radiolabeled fatty acids. We also show that Rv1272c causes a significant increase in the metabolic incorporation of radiolabeled long-chain fatty acids into cardiolipin, a tetra-acylated phospholipid, and phosphatidylglycerol in E. coli. This is the first report on the function of Rv1272c showing that it displays a long-chain fatty acid transport function. Copyright © 2018 Elsevier Inc. All rights reserved.

  6. Comprehensive sieve analysis of breakthrough HIV-1 sequences in the RV144 vaccine efficacy trial.

    Directory of Open Access Journals (Sweden)

    Paul T Edlefsen

    2015-02-01

    Full Text Available The RV144 clinical trial showed the partial efficacy of a vaccine regimen with an estimated vaccine efficacy (VE of 31% for protecting low-risk Thai volunteers against acquisition of HIV-1. The impact of vaccine-induced immune responses can be investigated through sieve analysis of HIV-1 breakthrough infections (infected vaccine and placebo recipients. A V1/V2-targeted comparison of the genomes of HIV-1 breakthrough viruses identified two V2 amino acid sites that differed between the vaccine and placebo groups. Here we extended the V1/V2 analysis to the entire HIV-1 genome using an array of methods based on individual sites, k-mers and genes/proteins. We identified 56 amino acid sites or "signatures" and 119 k-mers that differed between the vaccine and placebo groups. Of those, 19 sites and 38 k-mers were located in the regions comprising the RV144 vaccine (Env-gp120, Gag, and Pro. The nine signature sites in Env-gp120 were significantly enriched for known antibody-associated sites (p = 0.0021. In particular, site 317 in the third variable loop (V3 overlapped with a hotspot of antibody recognition, and sites 369 and 424 were linked to CD4 binding site neutralization. The identified signature sites significantly covaried with other sites across the genome (mean = 32.1 more than did non-signature sites (mean = 0.9 (p < 0.0001, suggesting functional and/or structural relevance of the signature sites. Since signature sites were not preferentially restricted to the vaccine immunogens and because most of the associations were insignificant following correction for multiple testing, we predict that few of the genetic differences are strongly linked to the RV144 vaccine-induced immune pressure. In addition to presenting results of the first complete-genome analysis of the breakthrough infections in the RV144 trial, this work describes a set of statistical methods and tools applicable to analysis of breakthrough infection genomes in general vaccine

  7. Induction surface hardening of hard coated steels

    Energy Technology Data Exchange (ETDEWEB)

    Pantleon, K.; Kessler, O.; Hoffann, F.; Mayr, P. [Stiftung Inst. fuer Werkstofftechnik, Bremen (Germany)

    1999-11-01

    The properties of hard coatings deposited using CVD processes are usually excellent. However, high deposition temperatures negatively influence the substrate properties, especially in the case of low alloyed steels. Therefore, a subsequent heat treatment is necessary to restore the properties of steel substrates. Here, induction surface hardening is used as a method of heat treatment after the deposition of TiN hard coatings on AISI 4140 (DIN42CrMo4) substrates. The influences of the heat treatment on both the coating and the substrate properties are discussed in relation to the parameters of induction heating. Thereby, the heating time, heating atmosphere and the power input into the coating-substrate compounds are varied. As a result of induction surface hardening, the properties of the substrates are improved without losing good coating properties. High hardness values in the substrate near the interface allow the AISI 4140 substrates to support TiN hard coatings very well. Consequently, higher critical loads are measured in scratch tests after the heat treatment. Also, compressive residual stresses in the substrate are generated. In addition, only a very low distortion appears. (orig.)

  8. Preparation of Dispersion-Hardened Copper by Internal Oxidation

    DEFF Research Database (Denmark)

    Brøndsted, Povl; Sørensen, Ole Toft

    1978-01-01

    Internal oxidation experiments in CO2/CO atmospheres on Cu-Al alloys for preparation of dispersion-hardened Cu are described. The oxygen pressures of the atmospheres used in the experiments were controlled with a solid electrolyte oxygen cell based on ZrO2 (CaO). The particle size distributions o...

  9. Radiation-hardened CMOS integrated circuits

    International Nuclear Information System (INIS)

    Pikor, A.; Reiss, E.M.

    1980-01-01

    Substantial effort has been directed at radiation-hardening CMOS integrated circuits using various oxide processes. While most of these integrated circuits have been successful in demonstrating megarad hardness, further investigations have shown that the 'wet-oxide process' is most compatible with the RCA CD4000 Series process. This article describes advances in the wet-oxide process that have resulted in multimegarad hardness and yield to MIL-M-38510 screening requirements. The implementation of these advances into volume manufacturing is geared towards supplying devices for aerospace requirements such as the Defense Meterological Satellite program (DMSP) and the Global Positioning Satellite (GPS). (author)

  10. Behavior of surface residual stress in explosion hardened high manganese austenitic cast steel due to repeated impact loads

    International Nuclear Information System (INIS)

    Oda, Akira; Miyagawa, Hideaki

    1985-01-01

    Explosion hardened high manganese austenitic cast steel is being tried for rail crossing recently. From the previous studies, it became clear that high tensile residual stress was generated in the hardened surface layer by explosion and microcracks were observed. In this study, therefore, the behavior of surface residual stress in explosion hardened steel due to repeated impact loads was examined and compared with those of the original and shot peened steels. The results obtained are summarized as follows: (1) In the initial stage of the repetition of impact, high tensile surface residual stress in explosion hardened steel decreased rapidly with the repetition of impact, while those of the original and shot peened steels increased rapidly. This difference was attributed to the difference in depth of the work hardened layer in three testing materials. (2) Beyond 20 impacts the residual stress of three test specimens decreased gradually, and at more than 2000 impacts the compressive stress of about 500 MPa was produced regardless of the histories of working of testing materials. (3) The linear law in the second stage of residual stress fading was applicable to this case, and the range of the linear relationship was related to the depth of the work hardened layer of testing material. (4) From the changes in half-value breadth and peak intensity of diffraction X-ray, it was supposed that a peculiar microscopic strain exists in explosion hardened steel. (author)

  11. Crystallization and preliminary X-ray characterization of phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv

    International Nuclear Information System (INIS)

    Mathur, Divya; Anand, Kanchan; Mathur, Deepika; Jagadish, Nirmala; Suri, Anil; Garg, Lalit C.

    2007-01-01

    The phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv was crystallized and diffraction data were collected to 2.8 Å resolution. Phosphoglucose isomerase is a ubiquitous enzyme that catalyzes the isomerization of d-glucopyranose-6-phosphate to d-fructofuranose-6-phosphate. The present investigation reports the expression, purification, crystallization and preliminary crystallographic studies of the phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv, which shares 46% sequence identity with that of its human host. The recombinant protein, which was prepared using an Escherichia coli expression system, was crystallized by the hanging-drop vapour-diffusion method. The crystals diffracted to a resolution of 2.8 Å and belonged to the orthorhombic space group I2 1 2 1 2 1 , with unit-cell parameters a = 109.0, b = 119.8, c = 138.9 Å

  12. Space Qualified, Radiation Hardened, Dense Monolithic Flash Memory, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Radiation hardened nonvolatile memories for space is still primarily confined to EEPROM. There is high density effective or cost effective NVM solution available to...

  13. Identifying Vulnerabilities and Hardening Attack Graphs for Networked Systems

    Energy Technology Data Exchange (ETDEWEB)

    Saha, Sudip; Vullinati, Anil K.; Halappanavar, Mahantesh; Chatterjee, Samrat

    2016-09-15

    We investigate efficient security control methods for protecting against vulnerabilities in networked systems. A large number of interdependent vulnerabilities typically exist in the computing nodes of a cyber-system; as vulnerabilities get exploited, starting from low level ones, they open up the doors to more critical vulnerabilities. These cannot be understood just by a topological analysis of the network, and we use the attack graph abstraction of Dewri et al. to study these problems. In contrast to earlier approaches based on heuristics and evolutionary algorithms, we study rigorous methods for quantifying the inherent vulnerability and hardening cost for the system. We develop algorithms with provable approximation guarantees, and evaluate them for real and synthetic attack graphs.

  14. Optimized R functions for analysis of ecological community data using the R virtual laboratory (RvLab).

    Science.gov (United States)

    Varsos, Constantinos; Patkos, Theodore; Oulas, Anastasis; Pavloudi, Christina; Gougousis, Alexandros; Ijaz, Umer Zeeshan; Filiopoulou, Irene; Pattakos, Nikolaos; Vanden Berghe, Edward; Fernández-Guerra, Antonio; Faulwetter, Sarah; Chatzinikolaou, Eva; Pafilis, Evangelos; Bekiari, Chryssoula; Doerr, Martin; Arvanitidis, Christos

    2016-01-01

    Parallel data manipulation using R has previously been addressed by members of the R community, however most of these studies produce ad hoc solutions that are not readily available to the average R user. Our targeted users, ranging from the expert ecologist/microbiologists to computational biologists, often experience difficulties in finding optimal ways to exploit the full capacity of their computational resources. In addition, improving performance of commonly used R scripts becomes increasingly difficult especially with large datasets. Furthermore, the implementations described here can be of significant interest to expert bioinformaticians or R developers. Therefore, our goals can be summarized as: (i) description of a complete methodology for the analysis of large datasets by combining capabilities of diverse R packages, (ii) presentation of their application through a virtual R laboratory (RvLab) that makes execution of complex functions and visualization of results easy and readily available to the end-user. In this paper, the novelty stems from implementations of parallel methodologies which rely on the processing of data on different levels of abstraction and the availability of these processes through an integrated portal. Parallel implementation R packages, such as the pbdMPI (Programming with Big Data - Interface to MPI) package, are used to implement Single Program Multiple Data (SPMD) parallelization on primitive mathematical operations, allowing for interplay with functions of the vegan package. The dplyr and RPostgreSQL R packages are further integrated offering connections to dataframe like objects (databases) as secondary storage solutions whenever memory demands exceed available RAM resources. The RvLab is running on a PC cluster, using version 3.1.2 (2014-10-31) on a x86_64-pc-linux-gnu (64-bit) platform, and offers an intuitive virtual environmet interface enabling users to perform analysis of ecological and microbial communities based on

  15. The R/V Folger a Floating Laboratory: Teaching Marine Science Skills on Lake Champlain (Invited)

    Science.gov (United States)

    Manley, P.; Manley, T.

    2013-12-01

    for other members of the local educational community for the next 30 to 50 years. The R/V Folger hosts significant amount of lab space allowing for on-vessel processing of real time data, enhanced navigational capabilities, smart classroom technology and new instrumentation such as multi-beam and CTD-rosette system. This all aluminum new research vessel, besides providing a new platform for Middlebury College's students, will also be used to enable faculty at other local colleges to provide experiential training in research techniques that would otherwise be unavailable; provide research training to local K-12 teachers; offer outreach to "land-locked" institutions and organizations within our tri-state region (NY, NH and VT); the development of a nautical archaeology program in the Lake Champlain basin; and produce data with environmental benefits to the region.

  16. Re-hardening of hadron transverse mass spectra in relativistic heavy-ion collisions

    International Nuclear Information System (INIS)

    Ohnishi, A.; Otuka, N.; Sahu, P.K.; Isse, M.; Nara, Y.

    2001-01-01

    We analyze the spectra of pions and protons in heavy-ion collisions at relativistic energies from 2 A GeV to 65 + 65 A GeV by using a jet-implemented hadron-string cascade model. In this energy region, hadron transverse mass spectra first show softening until SPS energies, and re-hardening may emerge at RHIC energies. Since hadronic matter is expected to show only softening at higher energy densities, this re-hardening of spectra can be interpreted as a good signature of the quark-gluon plasma formation. (author)

  17. On use of radial evanescence remain term in kinematic hardening

    International Nuclear Information System (INIS)

    Geyer, P.

    1995-01-01

    This paper presents the interest which lies in non-linear kinematic hardening rule with radial evanescence remain term as proposed for modelling multiaxial ratchetting. From analytical calculations in the case of the tension/torsion test, this ratchetting is compared with that proposed by Armstrong and Frederick. A modification is then proposed for Chaboche's elastoplastic model with two non-linear kinematic variables, by coupling the two types of hardening by means of two scalar parameters. Identification of these two parameters returns to speculate on the directions of strain in order to adjust the ratchetting to experimental observations. Using biaxial ratchetting tests on stainless steel 316 L specimens at ambient temperature, it is shown that satisfactory modelling of multiaxial ratchetting is obtained. (author). 4 refs., 5 figs

  18. Hardening by annealing and softening by deformation in nanostructured metals

    DEFF Research Database (Denmark)

    Huang, X.; Hansen, N.; Tsuji, N.

    2006-01-01

    We observe that a nanostructured metal can be hardened by annealing and softened when subsequently deformed, which is in contrast to the typical behavior of a metal. Microstructural investigation points to an effect of the structural scale on fundamental mechanisms of dislocation-dislocation and ......We observe that a nanostructured metal can be hardened by annealing and softened when subsequently deformed, which is in contrast to the typical behavior of a metal. Microstructural investigation points to an effect of the structural scale on fundamental mechanisms of dislocation....... As a consequence, the strength decreases and the ductility increases. These observations suggest that for materials such as the nanostructured aluminum studied here, deformation should be used as an optimizing procedure instead of annealing....

  19. ORF73 LANA homologs of RRV and MneRV2 contain an extended RGG/RG-rich nuclear and nucleolar localization signal that interacts directly with importin β1 for non-classical nuclear import.

    Science.gov (United States)

    Howard, Kellie; Cherezova, Lidia; DeMaster, Laura K; Rose, Timothy M

    2017-11-01

    The latency-associated nuclear antigens (LANA) of KSHV and macaque RFHVMn, members of the RV1 rhadinovirus lineage, are closely related with conservation of complex nuclear localization signals (NLS) containing bipartite KR-rich motifs and RG-rich domains, which interact distinctly with importins α and ß1 for nuclear import via classical and non-classical pathways, respectively. RV1 LANAs are expressed in the nucleus of latently-infected cells where they inhibit replication and establish a dominant RV1 latency. Here we show that LANA homologs of macaque RRV and MneRV2 from the more distantly-related RV2 lineage, lack the KR-rich NLS, and instead have a large RG-rich NLS with multiple RG dipeptides and a conserved RGG motif. The RG-NLS interacts uniquely with importin β1, which mediates nuclear import and accumulation of RV2 LANA in the nucleolus. The alternative nuclear import and localization of RV2 LANA homologs may contribute to the dominant RV2 lytic replication phenotype. Copyright © 2017. Published by Elsevier Inc.

  20. Bactericidal impact of Ag, ZnO and mixed AgZnO colloidal nanoparticles on H37Rv Mycobacterium tuberculosis phagocytized by THP-1 cell lines.

    Science.gov (United States)

    Jafari, Alireza; Mosavari, Nader; Movahedzadeh, Farahnaz; Nodooshan, Saeedeh Jafari; Safarkar, Roya; Moro, Rossella; Kamalzadeh, Morteza; Majidpour, Ali; Boustanshenas, Mina; Mosavi, Tahereh

    2017-09-01

    The purpose of this research project was to infection of human macrophages (THP-1) cell lines by H 37 Rv strain of Mycobacterium tuberculosis (H 37 RvMTB) and find out the ratio/dilution of mixture silver (Ag NPs) and zinc oxide nanoparticles (ZnO NPs) whose ability to eliminate phagocytized bacteria compared to rifampicin. The colloidal Ag NPs and ZnO NPs were synthesized and their characteristics were evaluated. The THP-1 cell lines were infected with different concentration of H 37 RvMTB. Next, the infected cells were treated with different ratios/dilutions of Ag NPs, ZnO NPs and rifampicin. The THP-1 were lysed and were cultured in Lowenstein-Jensen agar medium, for eight weeks. The TEM and AFM images of NPs and H 37 RvMTB were supplied. It is observed that Ag NPs, 2 Ag :8 ZnO and 8 Ag :2 ZnO did not have any anti-tubercular effects on phagocytized H 37 RvMTB. Conversely, ZnO NPs somehow eliminated 18.7 × 10 4  CFU ml -1 of H 37 RvMTB in concentration of ∼ 0.468 ppm. To compare with 40 ppm of rifampicin, ∼ 0.663 ppm of 5 Ag :5 ZnO had the ability to kill of H 37 RvMTB, too. Based on previous research, ZnO NPs had strong anti-tubercular impact against H 37 RvMTB to in-vitro condition, but it was toxic in concentration of ∼ 0.468 ppm to both of THP-1 and normal lung (MRC-5) cell lines. It also seems that 5 Ag :5 ZnO is justified because in concentration of ∼ 0.663 ppm of 5 Ag :5 ZnO , phagocytized H 37 RvMTB into the THP-1 had died without any toxicity effects against THP-1 and also MRC-5 cell lines. It is obvious that the mixture of colloidal silver and zinc oxide NPs with ratio of 5 Ag :5 ZnO would be trustworthy options as anti-tubercular nano-drugs in future researches. Copyright © 2017. Published by Elsevier Ltd.

  1. Analysis of thermal ratchetting of a cylinder subjected to axially moving temperature front. Effect of kinematic hardening rule

    International Nuclear Information System (INIS)

    Ohno, Nobutada; Yari, Takashi; Kobayashi, Mineo

    1995-01-01

    When a cylinder is subjected to a temperature front moving cyclically in the axial direction, the circumferential plastic strain may accumulate with the increase of the number of cycles. This is a thermal ratchetting problem induced by a liquid surface moving in a cylinder, and it is important especially in designing fast breeder reactors. In the present paper, the effect of kinematic hardening rule on the thermal ratchetting analysis is discussed by implementing the following four kinds of kinematic hardening rules in a finite element analysis; the perfectly plastic model (PP), the linear kinematic hardening rule (LKH), the classical nonlinear kinematic hardening rule of Armstrong and Frederick (AF), and the rule proposed recently by Ohno and Wang (OW). It is shown that disregard of transient hardening after yielding leads to overestimating the thermal ratchetting, that a rule predicting larger mechanical ratchetting under uniaxial cyclic loading makes the thermal ratchetting more serious, and that the Ohno and Wang rule can render the analysis most realistic among them. (author)

  2. Influence of sand base preparation on properties of chromite moulding sands with sodium silicate hardened with selected methods

    Directory of Open Access Journals (Sweden)

    Stachowicz M.

    2017-03-01

    Full Text Available The paper presents a research on the relation between thermal preparation of chromite sand base of moulding sands containing sodium silicate, hardened with selected physical and chemical methods, and structure of the created bonding bridges. Test specimens were prepared of chromite sand - fresh or baked at 950°C for 10 or 24 hours - mixed with 0.5 wt.% of the selected non-modified inorganic binder and, after forming, were hardened with CO2 or liquid esters, dried traditionally or heated with microwaves at 2.45 GHz. It was shown on the grounds of SEM observations that the time of baking the base sand and the hardening method significantly affect structure of the bonding bridges and are correlated with mechanical properties of the moulding sands. It was found that hardening chromite-based moulding mixtures with physical methods is much more favourable than hardening with chemical methods, guaranteeing also more than ten times higher mechanical properties.

  3. Oxidation hardening kinetics of the rheological function G'/('/G') in asphalts

    KAUST Repository

    Juristyarini, Pramitha

    2011-07-29

    The authors used 9 asphalts oxidized at various temperatures and pressures to determine the hardening kinetics for the DSR function, an easily measured and meaningful surrogate for 15C ductility that relates well to age-related binder deterioration. For each asphalt, there is a rapid initial period that slows to a constant rate period. This constant rate period can be represented by carbonyl formation (oxidation) rate times a hardening susceptibility (HS). For the DSR function and viscosity, the HS and initial jump were pressure-but not temperature-dependent. The DSR function initial jump was relatively higher than the viscosity initial jump. © 2011 Taylor & Francis Group, LLC.

  4. Oxidation hardening kinetics of the rheological function G'/('/G') in asphalts

    KAUST Repository

    Juristyarini, Pramitha; Davison, Richard R.; Glover, Charles J.

    2011-01-01

    The authors used 9 asphalts oxidized at various temperatures and pressures to determine the hardening kinetics for the DSR function, an easily measured and meaningful surrogate for 15C ductility that relates well to age-related binder deterioration. For each asphalt, there is a rapid initial period that slows to a constant rate period. This constant rate period can be represented by carbonyl formation (oxidation) rate times a hardening susceptibility (HS). For the DSR function and viscosity, the HS and initial jump were pressure-but not temperature-dependent. The DSR function initial jump was relatively higher than the viscosity initial jump. © 2011 Taylor & Francis Group, LLC.

  5. Analysis and optimization of fault-tolerant embedded systems with hardened processors

    DEFF Research Database (Denmark)

    Izosimov, Viacheslav; Polian, Ilia; Pop, Paul

    2009-01-01

    In this paper we propose an approach to the design optimization of fault-tolerant hard real-time embedded systems, which combines hardware and software fault tolerance techniques. We trade-off between selective hardening in hardware and process reexecution in software to provide the required levels...... of fault tolerance against transient faults with the lowest-possible system costs. We propose a system failure probability (SFP) analysis that connects the hardening level with the maximum number of reexecutions in software. We present design optimization heuristics, to select the fault......-tolerant architecture and decide process mapping such that the system cost is minimized, deadlines are satisfied, and the reliability requirements are fulfilled....

  6. Evaluating system reliability and targeted hardening strategies of power distribution systems subjected to hurricanes

    International Nuclear Information System (INIS)

    Salman, Abdullahi M.; Li, Yue; Stewart, Mark G.

    2015-01-01

    Over the years, power distribution systems have been vulnerable to extensive damage from hurricanes which can cause power outage resulting in millions of dollars of economic losses and restoration costs. Most of the outage is as a result of failure of distribution support structures. Over the years, various methods of strengthening distribution systems have been proposed and studied. Some of these methods, such as undergrounding of the system, have been shown to be unjustified from an economic point of view. A potential cost-effective strategy is targeted hardening of the system. This, however, requires a method of determining critical parts of a system that when strengthened, will have greater impact on reliability. This paper presents a framework for studying the effectiveness of targeted hardening strategies on power distribution systems subjected to hurricanes. The framework includes a methodology for evaluating system reliability that relates failure of poles and power delivery, determination of critical parts of a system, hurricane hazard analysis, and consideration of decay of distribution poles. The framework also incorporates cost analysis that considers economic losses due to power outage. A notional power distribution system is used to demonstrate the framework by evaluating and comparing the effectiveness of three hardening measures. - Highlight: • Risk assessment of power distribution systems subjected to hurricanes is carried out. • Framework for studying effectiveness of targeted hardening strategies is presented. • A system reliability method is proposed. • Targeted hardening is cost effective for existing systems. • Economic losses due to power outage should be considered for cost analysis.

  7. Hardening of ODS ferritic steels under irradiation with high-energy heavy ions

    Science.gov (United States)

    Ding, Z. N.; Zhang, C. H.; Yang, Y. T.; Song, Y.; Kimura, A.; Jang, J.

    2017-09-01

    Influence of the nanoscale oxide particles on mechanical properties and irradiation resistance of oxide-dispersion-strengthened (ODS) ferritic steels is of critical importance for the use of the material in fuel cladding or blanket components in advanced nuclear reactors. In the present work, impact of structures of oxide dispersoids on the irradiation hardening of ODS ferritic steels was studied. Specimens of three high-Cr ODS ferritic steels containing oxide dispersoids with different number density and average size were irradiated with high-energy Ni ions at about -50 °C. The energy of the incident Ni ions was varied from 12.73 MeV to 357.86 MeV by using an energy degrader at the terminal so that a plateau of atomic displacement damage (∼0.8 dpa) was produced from the near surface to a depth of 24 μm in the specimens. A nanoindentor (in constant stiffness mode with a diamond Berkovich indenter) and a Vickers micro-hardness tester were used to measure the hardeness of the specimens. The Nix-Gao model taking account of the indentation size effect (ISE) was used to fit the hardness data. It is observed that the soft substrate effect (SSE) can be diminished substantially in the irradiated specimens due to the thick damaged regions produced by the Ni ions. A linear correlation between the nano-hardeness and the micro-hardness was found. It is observed that a higher number density of oxide dispersoids with a smaller average diameter corresponds to an increased resistance to irradiation hardening, which can be ascribed to the increased sink strength of oxides/matrix interfaces to point defects. The rate equation approach and the conventional hardening model were used to analyze the influence of defect clusters on irradiation hardening in ODS ferritic steels. The numerical estimates show that the hardening caused by the interstitial type dislocation loops follows a similar trend with the experiment data.

  8. An Innovative Radiation Hardened CAM Architecture

    CERN Document Server

    Shojaii, Seyed Ruhollah; The ATLAS collaboration

    2018-01-01

    This article describes an innovative Content Addressable Memory (CAM) cell with radiation hardened (RH) architecture. The RH-CAM is designed in a commercial 28 nm CMOS technology. The circuit has been simulated in worst-case conditions, and the effects due to single particles have been analyzed by injecting a current pulse into a circuit node. The proposed architecture is suitable for on-time pattern recognition tasks in harsh environments, such as front-end electronics in hadron colliders and in space applications.

  9. Use of intraspecific variation in thermal responses for estimating an elevational cline in the timing of cold hardening in a sub-boreal conifer.

    Science.gov (United States)

    Ishizuka, W; Ono, K; Hara, T; Goto, S

    2015-01-01

    To avoid winter frost damage, evergreen coniferous species develop cold hardiness with suitable phenology for the local climate regime. Along the elevational gradient, a genetic cline in autumn phenology is often recognised among coniferous populations, but further quantification of evolutionary adaptation related to the local environment and its responsible signals generating the phenological variation are poorly understood. We evaluated the timing of cold hardening among populations of Abies sachalinensis, based on time series freezing tests using trees derived from four seed source populations × three planting sites. Furthermore, we constructed a model to estimate the development of hardening from field temperatures and the intraspecific variations occurring during this process. An elevational cline was detected such that high-elevation populations developed cold hardiness earlier than low-elevation populations, representing significant genetic control. Because development occurred earlier at high-elevation planting sites, the genetic trend across elevation overlapped with the environmental trend. Based on the trade-off between later hardening to lengthen the active growth period and earlier hardening to avoid frost damage, this genetic cline would be adaptive to the local climate. Our modelling approach estimated intraspecific variation in two model components: the threshold temperature, which was the criterion for determining whether the trees accumulated the thermal value, and the chilling requirement for trees to achieve adequate cold hardiness. A higher threshold temperature and a lower chilling requirement could be responsible for the earlier phenology of the high-elevation population. These thermal responses may be one of the important factors driving the elevation-dependent adaptation of A. sachalinensis. © 2014 German Botanical Society and The Royal Botanical Society of the Netherlands.

  10. Online frequency adjustment for energy optimisation of induction hardening processes; Energetische Optimierung von Induktionshaertungsprozessen durch Online-Frequenzanpassung

    Energy Technology Data Exchange (ETDEWEB)

    Ulferts, Alexander; Andrae, Frank [HWG Inductoheat GmbH, Reichenbach (Germany)

    2011-06-15

    It is frequently necessary to harden multiple points on a component. The hardness specification may, in many cases, be variable, and the boundary conditions often diverse. The relevant sectors of the component are in many cases more deeply hardened, to enhance strength and vibration-fatigue properties, with simultaneous retention of ductile properties in the core, in order to reduce the danger of fracture of the heat-treated component in service. In other cases, the hardening process is intended more to provide protection against elevated surface loadings and against abrasive erosion of material. Both of these applications are illustrated on the basis of a component in the context of this article, and the requirements made on the inductive hardening process discussed. The authors consciously raise the question of the limits of technical feasibility. (orig.)

  11. Antigenicity and Immunogenicity of RV144 Vaccine AIDSVAX Clade E Envelope Immunogen Is Enhanced by a gp120 N-Terminal Deletion

    Science.gov (United States)

    Liao, Hua-Xin; Tomaras, Georgia D.; Bonsignori, Mattia; Tsao, Chun-Yen; Hwang, Kwan-Ki; Chen, Haiyan; Lloyd, Krissey E.; Bowman, Cindy; Sutherland, Laura; Jeffries, Thomas L.; Kozink, Daniel M.; Stewart, Shelley; Anasti, Kara; Jaeger, Frederick H.; Parks, Robert; Yates, Nicole L.; Overman, R. Glenn; Sinangil, Faruk; Berman, Phillip W.; Pitisuttithum, Punnee; Kaewkungwal, Jaranit; Nitayaphan, Sorachai; Karasavva, Nicos; Rerks-Ngarm, Supachai; Kim, Jerome H.; Michael, Nelson L.; Zolla-Pazner, Susan; Santra, Sampa; Letvin, Norman L.; Harrison, Stephen C.

    2013-01-01

    An immune correlates analysis of the RV144 HIV-1 vaccine trial revealed that antibody responses to the gp120 V1/V2 region correlated inversely with infection risk. The RV144 protein immunogens (A244-rp120 and MN-rgp120) were modified by an N-terminal 11-amino-acid deletion (Δ11) and addition of a herpes simplex virus (HSV) gD protein-derived tag (gD). We investigated the effects of these modifications on gp120 expression, antigenicity, and immunogenicity by comparing unmodified A244 gp120 with both Δ11 deletion and gD tag and with Δ11 only. Analysis of A244 gp120, with or without Δ11 or gD, demonstrated that the Δ11 deletion, without the addition of gD, was sufficient for enhanced antigenicity to gp120 C1 region, conformational V2, and V1/V2 gp120 conformational epitopes. RV144 vaccinee serum IgGs bound more avidly to A244 gp120 Δ11 than to the unmodified gp120, and their binding was blocked by C1, V2, and V1/V2 antibodies. Rhesus macaques immunized with the three different forms of A244 gp120 proteins gave similar levels of gp120 antibody titers, although higher antibody titers developed earlier in A244 Δ11 gp120-immunized animals. Conformational V1/V2 monoclonal antibodies (MAbs) gave significantly higher levels of blocking of plasma IgG from A244 Δ11 gp120-immunized animals than IgG from animals immunized with unmodified A244 gp120, thus indicating a qualitative difference in the V1/V2 antibodies induced by A244 Δ11 gp120. These results demonstrate that deletion of N-terminal residues in the RV144 A244 gp120 immunogen improves both envelope antigenicity and immunogenicity. PMID:23175357

  12. Finite element implementation of strain-hardening Drucker–Prager plasticity model with application to tunnel excavation

    Directory of Open Access Journals (Sweden)

    K. Liu

    2017-09-01

    Full Text Available This paper presents a finite element implementation of a strain-hardening Drucker–Prager model and its application to tunnel excavation. The computational model was constructed based on the return mapping scheme, in which an elastic trial step was first executed, followed by plastic correction involving the Newton–Raphson method to return the predicted state of stresses to the supposed yield surface. By combining the plastic shear hardening rule and stress correction equations, the loading index for the strain-hardening Drucker–Prager model was solved. It is therefore possible to update the stresses, elastic and plastic strains, and slope of the yield locus at the end of each incremental step. As an illustrative example, an integration algorithm was incorporated into ABAQUS through the user subroutine UMAT to solve the tunnel excavation problem in strain-hardening Drucker–Prager rock formations. The obtained numerical results were found to be in excellent agreement with the available analytical solutions, thus indicating the validity and accuracy of the proposed UMAT code, as well as the finite element model.

  13. Surface transformation hardening on steels treated with solar energy in central tower and heliostats field

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, G.P.; Lopez, V.; de Damborenea, J.J.; Vazquez, A.J. [Centro Nacional de Investigaciones Metalurgicas CENIM/CSIC, Madrid (Spain)

    1995-04-28

    The possibility of surface hardening on AISI 4140 steel treated with concentrated solar energy in solar installations for electricity production has been studied. The samples were slides from a 35 mm diameter steel bar and their height was 35 mm. The quenching was made in water but also was considered the possibility of self-quenching by cooling in air. The amount of the surface hardness and the different structures obtained in both cases are presented, and some discussion is made with reference to the surface hardness, the hardness profiles and the structures obtained. The heating of steel with concentrated solar energy may produce similar hardening to that obtained with more conventional techniques of surface hardening

  14. Process controls for radiation hardened aluminum gate bulk silicon CMOS

    International Nuclear Information System (INIS)

    Gregory, B.L.

    1975-01-01

    Optimized dry oxides have recently yielded notable improvements in CMOS radiation-hardness. By following the proper procedures and recipes, it is now possible to produce devices which will function satisfactorily after exposure to a total ionizing dose in excess of 10 6 RADS (Si). This paper is concerned with the controls required on processing parameters once the optimized process is defined. In this process, the pre-irradiation electrical parameters must be closely controlled to insure that devices will function after irradiation. In particular, the specifications on n- and p-channel threshold voltages require tight control of fixed oxide charge, surface-state density, oxide thickness, and substrate and p-well surface concentrations. In order to achieve the above level of radiation hardness, certain processing procedures and parameters must also be closely controlled. Higher levels of cleanliness are required in the hardened process than are commonly required for commercial CMOS since, for hardened dry oxides, no impurity gettering can be employed during or after oxidation. Without such gettering, an unclean oxide is unacceptable due to bias-temperature instability. Correct pre-oxidation cleaning, residual surface damage removal, proper oxidation and annealing temperatures and times, and the correct metal sintering cycle are all important in determining device hardness. In a reproducible, hardened process, each of these processing steps must be closely controlled. (U.S.)

  15. Conserved hypothetical protein Rv1977 in Mycobacterium tuberculosis strains contains sequence polymorphisms and might be involved in ongoing immune evasion.

    Science.gov (United States)

    Jiang, Yi; Liu, Haican; Wang, Xuezhi; Li, Guilian; Qiu, Yan; Dou, Xiangfeng; Wan, Kanglin

    2015-01-01

    Host immune pressure and associated parasite immune evasion are key features of host-pathogen co-evolution. A previous study showed that human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved and thus it was deduced that M. tuberculosis lacks antigenic variation and immune evasion. Here, we selected 151 clinical Mycobacterium tuberculosis isolates from China, amplified gene encoding Rv1977 and compared the sequences. The results showed that Rv1977, a conserved hypothetical protein, is not conserved in M. tuberculosis strains and there are polymorphisms existed in the protein. Some mutations, especially one frameshift mutation, occurred in the antigen Rv1977, which is uncommon in M.tb strains and may lead to the protein function altering. Mutations and deletion in the gene all affect one of three T cell epitopes and the changed T cell epitope contained more than one variable position, which may suggest ongoing immune evasion.

  16. Radiation effects on radiation-hardened KU and KS-4V optical fibres

    International Nuclear Information System (INIS)

    Ivanov, A.A.; Tugarinov, S.N.; Kaschuck, Y.A.; Krasilnikov, A.V.; Bender, S.E.

    1999-01-01

    The aim of this work was to test the un-pretreated and the hardened (H 2 -loaded and pre-irradiated) KS-4V and KU optical fibres in reactor environment by in-situ measurements of both the radiation-induced loss and the luminescence in the visible spectral region. Both the radio-luminescent and the transmission spectra were in-situ detected during irradiation by charge-coupled-device (CCD) linear detector in the visible spectral region of 400 to 700 nm. The radiation induced loss spectra at the fast neutron fluence of 2*10 6 n/cm 2 shows the hardened, H 2 -loading and pre-irradiating effects in the both KU and KS-4V fibres. KU un-pretreated fibre shows a big radiation absorption band of non-bridging oxygen centered at the wavelength of 630 nm. It appears that the KS-4V hardened fibre has a specific point in the loss spectrum in the vicinity of 460 nm. Other measurements were performed, particularly after reactor shutdown and at 3 different neutron fluences with constant neutron flux after restarting

  17. Ultrafine-Grained Precipitation Hardened Copper Alloys by Swaging or Accumulative Roll Bonding

    Directory of Open Access Journals (Sweden)

    Igor Altenberger

    2015-05-01

    Full Text Available There is an increasing demand in the industry for conductive high strength copper alloys. Traditionally, alloy systems capable of precipitation hardening have been the first choice for electromechanical connector materials. Recently, ultrafine-grained materials have gained enormous attention in the materials science community as well as in first industrial applications (see, for instance, proceedings of NANO SPD conferences. In this study the potential of precipitation hardened ultra-fine grained copper alloys is outlined and discussed. For this purpose, swaging or accumulative roll-bonding is applied to typical precipitation hardened high-strength copper alloys such as Corson alloys. A detailed description of the microstructure is given by means of EBSD, Electron Channeling Imaging (ECCI methods and consequences for mechanical properties (tensile strength as well as fatigue and electrical conductivity are discussed. Finally the role of precipitates for thermal stability is investigated and promising concepts (e.g. tailoring of stacking fault energy for grain size reduction and alloy systems for the future are proposed and discussed. The relation between electrical conductivity and strength is reported.

  18. Process for hardening synthetic resins by ionizing radiation

    International Nuclear Information System (INIS)

    Hesse, W.; Ritz, J.

    1975-01-01

    Synthetic resins containing hydroxy groups and polymerizable carbon-carbon bonds are reacted with diketenes to yield aceto ester derivatives, which when reacted with metal compounds to form chelates, and mixed with copolymerizable monomers, are capable of being hardened by unusually low radiation doses to form coatings and articles with superior properties. (E.C.B.)

  19. Relationship Between Bake Hardening, Snoek-Köster and Dislocation-Enhanced Snoek Peaks in Coarse Grained Low Carbon Steel

    Directory of Open Access Journals (Sweden)

    Li Weijuan

    2016-09-01

    Full Text Available In the present work, specimens prepared from coarse grained low carbon steel with different prestrains were baked and then, their bake hardening (BH property and internal friction were determined. TEM was used to characterize the dislocation structure in BH treated samples. The measurements of internal friction in prestrained samples and baked samples were carried out using a multifunctional internal friction apparatus. The results indicate that, in coarse grained low carbon steel, the bake hardening properties (BH values were negative, which were increased by increasing the prestrain from 2 to 5%, and then were decreased by increasing the prestrain from 5 to 10%. In the specimen with prestrain 5%, the BH value reached the maximum value and the height of Snoek-Köster peak was observed to be the maximum alike. With increasing the prestrain, both of the BH value and Snoek-Köster peak heights are similarly varied. It is concluded that Snoek-Köster and dislocation-enhanced Snoek peaks, caused by the interactions between interstitial solute carbon atoms and dislocations, can be used in further development of the bake hardening steels.

  20. The influence of limited kinematic hardening in shakedown analysis

    International Nuclear Information System (INIS)

    Nery, Domingos E.S.; Jospin, Reinaldo R.; Zouain, Nestor

    2009-01-01

    The use of the Design by Analysis concept is a trend in modern pressure vessel and piping calculations. DBA flexibility allow us to deal with unexpected configurations detected at in-service inspections. It is also important, in life extension calculations, when deviations of the original standard hypothesis adopted initially in Design by Formula, can happen. To apply the DBA to structures under variable mechanic and thermal loads, it is necessary that, alternate plasticity and incremental collapse (with instantaneous plastic collapse as a particular case), be precluded. These are two basic failure modes considered by ASME or European Standards in DBA. The shakedown theory is the tool available to achieve this goal. In order to apply it, is necessary only the range of the variable loads and the material properties. Precise, robust and efficient algorithms to solve the very large nonlinear optimization problems generated in numerical applications of the shakedown theory is a recent achievement. Zouain and co-workers developed one of these algorithms for elastic ideally-plastic materials. But, it is necessary to consider more realistic material properties in real practical applications. This paper shows an enhancement of this algorithm to dealing with limited kinematic hardening, a typical property of the usual steels. This is done using internal thermodynamic variables. A discrete algorithm is obtained using a plane stress, mixed finite element, with internal variable. An example, a beam encased in an end, under constant axial force and variable moment is presented to show the importance of considering the limited kinematic hardening in a shakedown analysis. (author)