Crime and Insurgency in the Tribal Areas of Afghanistan and Pakistan

Science.gov (United States)

2010-10-15

formerly the NWFP)  LT    Lashkar‐e‐Taiba  LI     Lashkar‐e‐Islami  NATO  North Atlantic Treaty Organization  NDS    National Directorate of Security...Lashkar‐e‐Islami  ( LI ),  the  Islamic Movement  of Uzbekistan  (IMU),  the  Islamic  Jihad  Union (IJU), al‐Qa’ida and Lashkar‐e‐Jhangvi.    Note on...those  people without  any mercy.”57 When  U.S.  Marines pushed  into  Mian  Posteh  in Helmand province, villagers  initially  refused  to  frequent

Violent Jihad and Beheadings in the Land of Al Fatoni Darussalam

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Virginie Andre

2015-10-01

Full Text Available The early 2000s has seen a revival of the Patani resistance manifesting in a violent jihad and new forms of extreme violence never witnessed before in the century-long Southern Thailand conflict. Transported by neojihadism, this new energised generation of fighters is injecting new meaning to their struggle, re-identifying friends and foes, spreading terror in hearts and minds to control mental and physical spaces through the slashing of the body, all in the hope of establishing Al Fatoni Darussalam. This article examines the reflexive repositioning of the Patani struggle through the process of transference of neojihadism and its transformation into a glocalised violent jihad.

Perilaku agresif dan penanganannya melalui konseling islami

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Zain Irwanto

2017-06-01

Full Text Available The purpose of this study were (1 To determine the factors causing the emergence of Aggressive Behavior student at SMPN 1 Tondong Tallasa Pangkep district. (2 To know the description of the results of the counseling process Islami against the aggressive behavior of students at SMPN 1 Tondong Tallasa Pangkep district. This study used a qualitative approach to the type of case studies with data collection through interviews, observation, and documentation. The results showed that (1 the factors agtresif behavior was arrogant, selfish, family economy, family environment, (2 the application of Islamic counseling to the students' problems aggressive behavior indicate a change student behavior from aggressive to not be aggressive.

The GSPC: Newest Franchise in al-Qa'ida's Global Jihad

National Research Council Canada - National Science Library

Boudali, Lianne K

2007-01-01

... of support in Europe. The alignment of the GSPC with al Qa ida represents a significant change in the group's strategy, however, its decision to join al Qa ida's global jihad should be understood as an act of desperation...

Intracellular Distribution of Capsid-Associated pUL77 of Human Cytomegalovirus and Interactions with Packaging Proteins and pUL93.

Science.gov (United States)

Köppen-Rung, Pánja; Dittmer, Alexandra; Bogner, Elke

2016-07-01

DNA packaging into procapsids is a common multistep process during viral maturation in herpesviruses. In human cytomegalovirus (HCMV), the proteins involved in this process are terminase subunits pUL56 and pUL89, which are responsible for site-specific cleavage and insertion of the DNA into the procapsid via portal protein pUL104. However, additional viral proteins are required for the DNA packaging process. We have shown previously that the plasmid that encodes capsid-associated pUL77 encodes another potential player during capsid maturation. Pulse-chase experiments revealed that pUL77 is stably expressed during HCMV infection. Time course analysis demonstrated that pUL77 is expressed in the early late part of the infectious cycle. The sequence of pUL77 was analyzed to find nuclear localization sequences (NLSs), revealing monopartite NLSm at the N terminus and bipartite NLSb in the middle of pUL77. The potential NLSs were inserted into plasmid pHM829, which encodes a chimeric protein with β-galactosidase and green fluorescent protein. In contrast to pUL56, neither NLSm nor NLSb was sufficient for nuclear import. Furthermore, we investigated by coimmunoprecipitation whether packaging proteins, as well as pUL93, the homologue protein of herpes simplex virus 1 pUL17, are interaction partners of pUL77. The interactions between pUL77 and packaging proteins, as well as pUL93, were verified. We showed that the capsid-associated pUL77 is another potential player during capsid maturation of HCMV. Protein UL77 (pUL77) is a conserved core protein of HCMV. This study demonstrates for the first time that pUL77 has early-late expression kinetics during the infectious cycle and an intrinsic potential for nuclear translocation. According to its proposed functions in stabilization of the capsid and anchoring of the encapsidated DNA during packaging, interaction with further DNA packaging proteins is required. We identified physical interactions with terminase subunits pUL56 and pUL

Paradigmatic Shifts in Jihadism in Cyberspace: The Emerging Role of Unaffiliated Sympathizers in Islamic State’s Social Media Strategy

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Yannick Veilleux-Lepage

2016-02-01

Full Text Available 'This paper provides an overview of the evolution of the concept of jihadism as it presently exists in cyberspace. From its roots during the Chechen conflict to the current use of social media by the Islamic State (IS, this paper identifies and examines three highly significant paradigm shifts: (1 the emergence of rudimentary Web 2.0 platforms and jihadist forums; (2 the advent of advanced Web 2.0 and social media platforms as methods of spreading jihadism; and (3 turn towards ‘lone wolf’ terrorism.  In this paper, the author argues that IS’ extensive reliance on unaffiliated sympathizers, who either re-tweet or re-post content produced and authorized by the IS leadership can be seen as a groundbreaking paradigm shift in the evolution of jihadism in cyberspace. Furthermore, it is also argued that IS’ strategy of empowering of unaffiliated sympathizers represents a further development in the evolution of jihadism in cyberspace and can best be understood as an attempt to normalize and legitimize IS’ existence through its efforts to dominate the ‘IS narrative’ across social media platforms.' ' '

HSV-1 nucleocapsid egress mediated by UL31 in association with UL34 is impeded by cellular transmembrane protein 140

Energy Technology Data Exchange (ETDEWEB)

Guan, Ying [Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming 650118 (China); Yunnan Academy of Tobacco Science, Kunming, Yunnan 650106 (China); Guo, Lei; Yang, Erxia; Liao, Yun; Liu, Longding; Che, Yanchun; Zhang, Ying; Wang, Lichun; Wang, Jingjing [Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming 650118 (China); Li, Qihan, E-mail: imbcams.lq@gmail.com [Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medicine Science, Peking Union Medical College, Kunming 650118 (China)

2014-09-15

During HSV-1 infection, the viral UL31 protein forms a complex with the UL34 protein at the cellular nuclear membrane, where both proteins play important roles in the envelopment of viral nucleocapsids and their egress into the cytoplasm. To characterize the mechanism of HSV-1 nucleocapsid egress, we screened host proteins to identify proteins that interacted with UL31 via yeast two-hybrid analysis. Transmembrane protein 140 (TMEM140), was identified and confirmed to bind to and co-localize with UL31 during viral infection. Further studies indicated that TMEM140 inhibits HSV-1 proliferation through selectively blocking viral nucleocapsid egress during the viral assembly process. The blockage function of TMEM140 is mediated by impeding the formation of the UL31–UL34 complex due to competitive binding to UL31. Collectively, these data suggest the essentiality of the UL31–UL34 interaction in the viral nucleocapsid egress process and provide a new anti-HSV-1 strategy in viral assembly process of nucleocapsid egress. - Highlights: • Cellular TMEM140 protein interacts with HSV-1 UL31 protein during viral infection. • Increasing expression of TMEM140 leads to inhibition of HSV-1 proliferation. • Increasing expression of TMEM140 blocks HSV-1 nucleocapsid egress process. • Binding to UL31 of TMEM140 impedes formation of HSV-1 UL31–UL34 complex.

Indonesian Salafism on Jihad and Suicide Bombings

OpenAIRE

Rusli, Rusli

2014-01-01

This paper deals with jihad and suicide bombings from the perspective of Indonesian salafism. It is argued that there are two different points of view related to this issue. The first is those who are affiliated with Wahhabi salafists such as those involved in Salafi-based foundations like As-Sunnah, Ihyaut Turats, al-Sofwah, Lajnah al-Khairiyah, Lajnah al-Istiqamah, and Wahdah Islamiyyah. They do not agree with suicide bombing directed to Western targets—mainly America—and its symbols. Suici...

The Fulani Jihad and its Implication for National Integration and ...

African Journals Online (AJOL)

The Fulani Jihad (1804-1810) led by Shehu, Uthman Dan Fodio was successfully prosecuted against the established Hausa dynasty in Northern Nigeria. It led to the emergence of a theocratic state, the Sokoto Caliphate, which was administered largely as a federation, due to its wide expanse and diverse composition of its ...

MENARIK MINAT SISWA PADA LAYANAN BIMBINGAN DAN KONSELING ISLAMI DI SEKOLAH MENGGUNAKAN LAYANAN INFORMASI DENGAN TEKNIK MODELLING

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Ismah -

2016-08-01

Full Text Available Rendahnya minat siswa pada layanan bimbingan dan konseling terlihat dari minimnya siswa yang datang keruang BK untuk memanfaatkan layanan bimbingan dan konseling di sekolah. Permasalahan yang dikaji dalam penulisan ini adalah, Bagaiman layanan informasi dengan teknik modelling dapat menarik terhadap minat siswa pada layanan bimbingan dan konseling di sekolah khususnya bimbingan dan konseling islami. Tujuan yang hendak dicapai dalam penulisan ini adalah untuk memberi masukan kepada guru BK di sekolah supaya siswa-siswinya tertarik atau berminat berkunjung di ruang BK, menggunakan cara ”layanan informasi dengan teknik modelling terhadap minat siswa pada layanan bimbingan dan konseling siswa di sekolah khususnya bimbingan dan konseling islami”. Pada kajian ini dapat dianalisis bahwa: layanan informasi dengan teknik modelling, diharapkan dapat berdampak positif terhadap minat siswa berkunjung ke ruang BK, sehingga guru BK dapat memberi layanan bimbingan konseling khusunya bimbingan dan konseling islami dengan kesadaran siswa tanpa pemaksaan.

Mutations in the putative zinc-binding motif of UL52 demonstrate a complex interdependence between the UL5 and UL52 subunits of the human herpes simplex virus type 1 helicase/primase complex.

Science.gov (United States)

Chen, Yan; Carrington-Lawrence, Stacy D; Bai, Ping; Weller, Sandra K

2005-07-01

Herpes simplex virus type 1 (HSV-1) encodes a heterotrimeric helicase-primase (UL5/8/52) complex. UL5 contains seven motifs found in helicase superfamily 1, and UL52 contains conserved motifs found in primases. The contributions of each subunit to the biochemical activities of the complex, however, remain unclear. We have previously demonstrated that a mutation in the putative zinc finger at UL52 C terminus abrogates not only primase but also ATPase, helicase, and DNA-binding activities of a UL5/UL52 subcomplex, indicating a complex interdependence between the two subunits. To test this hypothesis and to further investigate the role of the zinc finger in the enzymatic activities of the helicase-primase, a series of mutations were constructed in this motif. They differed in their ability to complement a UL52 null virus: totally defective, partial complementation, and potentiating. In this study, four of these mutants were studied biochemically after expression and purification from insect cells infected with recombinant baculoviruses. All mutants show greatly reduced primase activity. Complementation-defective mutants exhibited severe defects in ATPase, helicase, and DNA-binding activities. Partially complementing mutants displayed intermediate levels of these activities, except that one showed a wild-type level of helicase activity. These data suggest that the UL52 zinc finger motif plays an important role in the activities of the helicase-primase complex. The observation that mutations in UL52 affected helicase, ATPase, and DNA-binding activities indicates that UL52 binding to DNA via the zinc finger may be necessary for loading UL5. Alternatively, UL5 and UL52 may share a DNA-binding interface.

THE PERFORMANCE OF RURAL DEVELOPMENT SCHEME IN ISLAMI BANK BANGLADESH FROM AN ISLAMIC PERSPECTIVE

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Mohammad Saiful Islam

2016-06-01

Full Text Available Islami Bank Bangladesh Limited (IBBL is one of the leading and efficient financial institutions in the globe. The Rural Development Scheme (RDS has become an exclusive domain to play a significant role in increasing the performance of development in nation building. As a result, IBBL is playing a vital role in the rural area in applying the RDS for poverty alleviation. The aim of this study is to analyze the performance of the RDS of IBBL in the rural area. This paper will also discuss the achievements of this scheme in the present context to evaluate its performance. Finally, the researcher will come up with some suggestions and recommendations for further improvement. =========================================== Bank Islami Bangladesh Limited (IBBL adalah salah satu lembaga keuangan terkemuka dan efisien di dunia. “Skema Pembangunan Pedesaan” (RDS telah menjadi suatu domain yang ekslusif dalam memainkan peranan yang signifikan bagi peningkatan performa dalam pembangunan negara. Sebagai hasilnya, IBBL memainkan peranan yang penting di daerah pedesaan dalam mengaplikasikan skama RDS bagi upaya penanggulangan kemiskinan. Tujuan penelitian ini adalah untuk menganalisa performa skema RDS dari IBBL di daerah pedesaan. Paper ini juga akan mendiskusikan pencapaian skaema ini dalam konteks saat ini guna mengevaluasi performanya. Pada akhirnya, peneliti akan menyampaikan beberapa saran dan rekomendasi untuk peningkatan di masa yang akan datang.

Global Jihad: The Role of Europe’s Radical Muslims

Science.gov (United States)

2007-12-01

social state governed by the rule of law.”41 Correspondingly, Turkish immigrants have not been involved in any jihadi activity that has occurred in...Muslims with no choice other than jihad to rectify their situation. 57 Dr. Vije Franchi ...Education National Focal Point for Germany,” 29. 63 Tikly, “Analytical Report on Education National Focal Point for Great Britain,” 19. 64 Franchi

The UL5 and UL52 subunits of the herpes simplex virus type 1 helicase-primase subcomplex exhibit a complex interdependence for DNA binding.

Science.gov (United States)

Biswas, N; Weller, S K

2001-05-18

Herpes simplex virus type 1 encodes a heterotrimeric helicase-primase complex composed of the products of the UL5, UL52, and UL8 genes. The UL5 protein contains seven motifs found in all members of helicase Superfamily 1 (SF1), and the UL52 protein contains several conserved motifs found in primases; however, the contributions of each subunit to the biochemical activities of the subcomplex are not clear. In this work, the DNA binding properties of wild type and mutant subcomplexes were examined using single-stranded, duplex, and forked substrates. A gel mobility shift assay indicated that the UL5-UL52 subcomplex binds more efficiently to the forked substrate than to either single strand or duplex DNA. Although nucleotides are not absolutely required for DNA binding, ADP stimulated the binding of UL5-UL52 to single strand DNA whereas ATP, ADP, and adenosine 5'-O-(thiotriphosphate) stimulated the binding to a forked substrate. We have previously shown that both subunits contact single-stranded DNA in a photocross-linking assay (Biswas, N., and Weller, S. K. (1999) J. Biol. Chem. 274, 8068-8076). In this study, photocross-linking assays with forked substrates indicate that the UL5 and UL52 subunits contact the forked substrates at different positions, UL52 at the single-stranded DNA tail and UL5 near the junction between single-stranded and double-stranded DNA. Neither subunit was able to cross-link a forked substrate when 5-iododeoxyuridine was located within the duplex portion. Photocross-linking experiments with subcomplexes containing mutant versions of UL5 and wild type UL52 indicated that the integrity of the ATP binding region is important for DNA binding of both subunits. These results support our previous proposal that UL5 and UL52 exhibit a complex interdependence for DNA binding (Biswas, N., and Weller, S. K. (1999) J. Biol. Chem. 274, 8068-8076) and indicate that the UL52 subunit may play a more active role in helicase activity than had previously been

PENDIDIKAN BERKARAKTER ISLAMI BAGI ANAK YATIM

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Abdurohman Misno Bambang Prawiro

2017-06-01

Full Text Available Pendidikan adalah hak setiap warga Negara Indonesia, sehingga pemerintah wajib menyediakan kesempatan seluas-luasnya kepada rakyatnya agar dapat memperoleh pendidikan yang berkualitas. Pembukaan UUD 1945 alinea 4 menyatakan bahwa Negara bertujuan mencerdaskan kehidupan bangsa. Efektifitas suatu proses pembelajaran secara umum ditentukan oleh kurikulum dan system pendidikan yang diterapkan pada lingkungan  pendidikan tersebut, berkaitan dengan pendidikan yang diterapkan terhadap anak yatim maka diperlukan adanya kurikulum khusus yang dapat menjawab dan mengakomodir kebutuhan seorang anak yatim, baik secara fisik maupun secara spiritual. Penelitian ini dilakukan di Pesantren Yatim Ibnu Taimiyah Bogor dengan audience santri-santri yatim dari jenjang Madrasah Ibtidaiyyah (MI, Madrasah Tsanawiyah (MTs dan Madrasah Aliyah (MA. Secara psikologi anak-anak yatim merasa kehilangan dengan meninggal-nya salah satu orang tua mereka yaitu ayah. Hasil dari penelitian ini menunjukan bahwa hilangnya figur ayah dalam kehidupan mereka mengakibatkan mereka merasa kurang terlindungi sehingga kepribadian mereka cenderung lebih bebas. Diperlukan adanya model pendidikan yang mengarahkan dan membimbing mereka untuk menjadi manusia yang mandiri baik pada saat proses pembelajarannya ataupun hasil dari pembelajaran tersebut. Pendidikan berkarakter Islami yang memberikan pola pembelajaran yang disesuaikan dengan tingkatan umur dan kematangan spiritual menjadi sesuatu yang harus ada bagi pendidikan mereka.

Identification of a novel linear B-cell epitope in the UL26 and UL26.5 proteins of Duck Enteritis Virus

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Kong Xiangang

2010-09-01

Full Text Available Abstract Background The Unique Long 26 (UL26 and UL26.5 proteins of herpes simplex virus are known to function during the assembly of the viruses. However, for duck enteritis virus (DEV, which is an unassigned member of the family Herpesviridae, little information is available about the function of the two proteins. In this study, the C-terminus of DEV UL26 protein (designated UL26c, which contains the whole of UL26.5, was expressed, and the recombinant UL26c protein was used to immunize BALB/c mice to generate monoclonal antibodies (mAb. The mAb 1C8 was generated against DEV UL26 and UL26.5 proteins and used subsequently to map the epitope in this region. Both the mAb and its defined epitope will provide potential tools for further study of DEV. Results A mAb (designated 1C8 was generated against the DEV UL26c protein, and a series of 17 partially overlapping fragments that spanned the DEV UL26c were expressed with GST tags. These peptides were subjected to enzyme-linked immunosorbent assay (ELISA and western blotting analysis using mAb 1C8 to identify the epitope. A linear motif, 520IYYPGE525, which was located at the C-terminus of the DEV UL26 and UL26.5 proteins, was identified by mAb 1C8. The result of the ELISA showed that this epitope could be recognized by DEV-positive serum from mice. The 520IYYPGE525 motif was the minimal requirement for reactivity, as demonstrated by analysis of the reactivity of 1C8 with several truncated peptides derived from the motif. Alignment and comparison of the 1C8-defined epitope sequence with those of other alphaherpesviruses indicated that the motif 521YYPGE525 in the epitope sequence was conserved among the alphaherpesviruses. Conclusion A mAb, 1C8, was generated against DEV UL26c and the epitope-defined minimal sequence obtained using mAb 1C8 was 520IYYPGE525. The mAb and the identified epitope may be useful for further study of the design of diagnostic reagents for DEV.

Risk Management Practices in Islamic Bank: A Case Study of Islami Bank Bangladesh Limited

OpenAIRE

Uddin, Md Akther

2015-01-01

Islamic banking industry has been growing rapidly for last three decades. As risk is inherent in banking business it is necessary to develop a comprehensive risk management framework and process. In this paper, a humble attempt has been made to study and analyze risk management practices of Islami Bank Bangladesh Limited (IBBL), one of the leading Islamic banks in Bangaladesh. Annual reports of IBBL and 7 other full-fledged Islamic banks, Bangladesh Bank, the central bank of Bangladesh, publi...

MEMBENTUK LINGKUNGAN PENDIDIKAN YANG ISLAMI

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Wartono *

2017-06-01

Full Text Available Islam adalah agama yang sempurna. Kesempurnaan Islam meliputi seluruh aspek-aspek kehidupan. Mulai dari pen-ciptaan manusia, proses terjadinya manusia, tujuan penciptaan manusia, bahan baku manusia, penciptaan langit dan bumi, penciptaan jin, lingkungan hidup, ekonomi, politik, sejarah, angkatan bersenjata, pendidikan dan lain-lain. Bertolak dari kesempurnaan Islam sebagaimana tersebut di atas, maka sudah semesinya setiap muslim menjadikan Islam sebagai rujukan setiap persoalan yang dihadapinya. Hanya kembali kepada Islamlah manusia akan mendapatkan keselamatan,  kebaikan, kedamaian, kebahagiaan keuntungan dunia dan akhirat. Dengan Islamlah manusia dapat membentuk lingkungan pedidikannya dengan baik. Sebab Islam senantiasa memberi perhatian yang sangat serius dan utama  terhadap lingkungan  pendidikan yang islami. Manusi tidak akan menjadi hamba yang taat kepada Allah dan Rasul-Nya jika tidak dididik berdasarkan Islam. Tidak ada konsep dan teori di luar Isalam yang mampu memberikan kontribusi secara integral terhadap pendidikan manusia seutuhnya,sehingga manusia  menajdi orang yang beriman. Yang paling tahu tentang manusia bukanlah manusi itu sendiri, akan tetapi yang menciptakan manusia yaitu Allah . Allah Ta’ala memilih Muhammad seorang Rasul dengan tujuan agar beliau menyampaikan risalah-Nya. Risalah yang dibawa oleh Nabi itu berisi nilai-nilai yang sangat tinggi sehingga dapat mengangkat derajat manusia dan martabat pada tingkat yang tinggi.Jika manusia mau menjalankan risalah yang dibawa oleh Muhammad secara benar, maka mereka akan mendapatkan predikat mu’min dan pada gilirannya orang-orang mu’min itu akan ditempatkan di dalam surga.

Laskar Jihad : Islam, militancy and the quest for identity in post-New Order Indonesia

NARCIS (Netherlands)

2005-01-01

This study analyses the intellectual and political history of Laskar Jihad, the most spectacular Muslim paramilitary group that emerged in Indonesia in the aftermath of the collapse of the New Order regime in May 1998. Using an interpretive framework derived from social movement theory and identity

CRISPR/Cas9 Mutagenesis of UL21 in Multiple Strains of Herpes Simplex Virus Reveals Differential Requirements for pUL21 in Viral Replication

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Renée L. Finnen

2018-05-01

Full Text Available Studies from multiple laboratories using different strains or species of herpes simplex virus (HSV with deletions in UL21 have yielded conflicting results regarding the necessity of pUL21 in HSV infection. To resolve this discrepancy, we utilized CRISPR/Cas9 mutagenesis to isolate pUL21 deficient viruses in multiple HSV backgrounds, and performed a side-by-side comparison of the cell-to-cell spread and replication phenotypes of these viruses. These analyses confirmed previous studies implicating the involvement of pUL21 in cell-to-cell spread of HSV. Cell-to-cell spread of HSV-2 was more greatly affected by the lack of pUL21 than HSV-1, and strain-specific differences in the requirement for pUL21 in cell-to-cell spread were also noted. HSV-2 strain 186 lacking pUL21 was particularly crippled in both cell-to-cell spread and viral replication in non-complementing cells, in comparison to other HSV strains lacking pUL21, suggesting that the strict requirement for pUL21 by strain 186 may not be representative of the HSV-2 species as a whole. This work highlights CRISPR/Cas9 technology as a useful tool for rapidly constructing deletion mutants of alphaherpesviruses, regardless of background strain, and should find great utility whenever strain-specific differences need to be investigated.

A Challenge for Social Studies Educators: Teaching about Islam, "Jihad," and "Shari'ah" Law

Science.gov (United States)

Moore, James R.

2012-01-01

In this article, the author investigates the controversial curricular and instructional aspects of teaching about Islam in social studies courses. Specifically, the author discusses pedagogically sound approaches to teaching about "jihad" and "Shari'ah" law, two of the most important and controversial concepts in Islam that often generate intense…

Expression and characterization of UL16 gene from duck enteritis virus

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Wang Mingshu

2011-08-01

Full Text Available Abstract Background Previous studies have indicated that the UL16 protein and its homologs from herpesvirus were conserved and played similar roles in viral DNA packaging, virion assembly, budding, and egress. However, there was no report on the UL16 gene product of duck enteritis virus (DEV. In this study, we analyzed the amino acid sequence of UL16 using bioinformatics tools and expressed in Escherichia coli Rosetta (DE3 induced by isopropy1-β-D-thiogalactopyranoside (IPTG. The recombinant protein was produced, purified using a Ni-NTA column and used to generate the polyclonal antibody against UL16. The intracellular distribution of the DEV UL16 product was carried out using indirect immunofluorescence assay. Results In our study, UL16 gene of DEV was composed of 1089 nucleotides, which encoded 362 amino acids. Multiple sequence alignment suggested that the UL16 gene was highly conserved in herpesvirus family. The UL16 gene was cloned into a pET prokaryotic expression vector and transformed into Escherichia coli Rossetta (DE3 induced by IPTG. A 60kDa fusion protein band corresponding to the predicted size was produced on the SDS-PAGE, purified using a Ni-NTA column. Anti-UL16 polyclonal sera was prepared by immunizing rabbits, and reacted with a band in the IPTG induced cell lysates with an apparent molecular mass of 60 kDa. In vivo expression of the UL16 protein in DEV infected duck embryo fibroblast cells (DEFs was localized mostly around perinuclear cytoplasmic area and in cytosol using indirect immunofluorescence assay. Conclusions The UL16 gene of DEV was successfully cloned, expressed and detected in DEV infected DEFs for the first time. The UL16 protein localized mostly around perinuclear cytoplasmic area and in cytosol in DEV infected DEFs. DEV UL16 shared high similarity with UL16 family members, indicating that DEV UL16 many has similar function with its homologs. All these results may provide some insight for further research about

The herpes simplex virus 1 UL51 protein interacts with the UL7 protein and plays a role in its recruitment into the virion.

Science.gov (United States)

Roller, Richard J; Fetters, Rachel

2015-03-01

The alphaherpesvirus UL51 protein is a tegument component that interacts with the viral glycoprotein E and functions at multiple steps in virus assembly and spread in epithelial cells. We show here that pUL51 forms a complex in infected cells with another conserved tegument protein, pUL7. This complex can form in the absence of other viral proteins and is largely responsible for recruitment of pUL7 to cytoplasmic membranes and into the virion tegument. Incomplete colocalization of pUL51 and pUL7 in infected cells, however, suggests that a significant fraction of the population of each protein is not complexed with the other and that they may accomplish independent functions. The ability of herpesviruses to spread from cell to cell in the face of an immune response is critical for disease and shedding following reactivation from latency. Cell-to-cell spread is a conserved ability of herpesviruses, and the identification of conserved viral genes that mediate this process will aid in the design of attenuated vaccines and of novel therapeutics. The conserved UL51 gene of herpes simplex virus 1 plays important roles in cell-to-cell spread and in virus assembly in the cytoplasm, both of which likely depend on specific interactions with other viral and cellular proteins. Here we identify one of those interactions with the product of another conserved herpesvirus gene, UL7, and show that formation of this complex mediates recruitment of UL7 to membranes and to the virion. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

UL146 variability among clinical isolates of Human Cytomegalovirus from Japan

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Francisco Aguayo

2010-01-01

Full Text Available Human Cytomegalovirus (HCMV is a herpesvirus associated with serious diseases in immunocompromised subjects. The region between ORF UL133 and UL151 from HCMV, named ULb' is frequently deleted in attenuated AD169 and in highly passaged laboratory strains. However, this region is conserved in low-passaged and more virulent HCMV, like the Toledo strain. The UL146 gene, which is located in the ULb' region, encodes a CXC-chemokine analogue. The diversity of UL146 gene was evaluated among fifty-six clinical isolates of HCMV from Japan. Results show that UL146 gene was successfully amplified by the polymerase chain reaction (PCR in only 17/56 strains (30%, while the success rate for UL145/UL147 gene was 18/56 strains (32%. After DNA sequencing, the 35 amplified strains were classified into 8 groups. When compared, variability of UL146 ranged from 25.1% to 52.9% at the DNA level and from 34.5% to 67% at the amino acid level. Seven groups had the interleukin-8 (IL-8 motif ERL (Glu-Leu-Arg CXC and one group had only the CXC motif, suggesting the absence of the IL-8 function of UL146. In conclusion, we found that UL146 gene of HCMV is hyper-variable in clinical strains from Japan suggesting the possibility of a different function in each sequence group.

Nuclear body formation and PML body remodeling by the human cytomegalovirus protein UL35

International Nuclear Information System (INIS)

Salsman, Jayme; Wang Xueqi; Frappier, Lori

2011-01-01

The human cytomegalovirus (HCMV) UL35 gene encodes two proteins, UL35 and UL35a. Expression of UL35 in transfected cells results in the formation of UL35 nuclear bodies that associate with promyelocytic leukemia (PML) protein. PML forms the basis for PML nuclear bodies that are important for suppressing viral lytic gene expression. Given the important relationship between PML and viral infection, we have further investigated the association of UL35 with PML bodies. We demonstrate that UL35 bodies form independently of PML and subsequently recruit PML, Sp100 and Daxx. In contrast, UL35a did not form bodies; however, it could bind UL35 and inhibit the formation of UL35 bodies. The HCMV tegument protein pp71 promoted the formation of UL35 bodies and the cytoplasmic localization of UL35a. Similarly, UL35a shifted pp71 to the cytoplasm. These results indicate that the interplay between UL35, UL35a and pp71 affects their subcellular localization and likely their functions throughout infection.

Expression and characterization of the UL31 protein from duck enteritis virus

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Zhu Dekang

2009-02-01

Full Text Available Abstract Background Previous studies indicate that the UL31 protein and its homology play similar roles in nuclear egress of all herpesviruses. However, there is no report on the UL31 gene product of DEV. In this study, we expressed and presented the basic properties of the DEV UL31 product. Results The entire ORF of the UL31 was cloned into pET 32a (+ prokaryotic expression vector. Escherichia coli BL21(DE3 competent cells were transformed with the construct followed by the induction of protein expression by the addition of IPTG. Band corresponding to the predicted sizes (55 kDa was produced on the SDS-PAGE. Over expressed 6×His-UL31 fusion protein was purified by nickel affinity chromatography. The DEV UL31 gene product has been identified by using a rabbit polyclonal antiserum raised against the purified protein. A protein of approximate 35 kDa that reacted with the antiserum was detected in immunoblots of DEV-infected cellular lysates, suggesting that the 35 kDa protein was the primary translation product of the UL31 gene. RT-PCR analyses revealed that the UL31 gene was transcribed most abundantly during the late phase of replication. Subsequently, Immunofluorescence analysis revealed that the protein was widespread speckled structures in the nuclei of infected cells. Western blotting of purified virion preparations showed that UL31 was a component of intracellular virions but was absent from mature extracellular virions. Finally, an Immunofluorescence assay was established to study the distribution of the UL31 antigen in tissues of artificially DEV infected ducks. The results showed that the UL31 antigen was primarily located in the cells of digestive organs and immunological organs. Conclusion In this work, we present the basic properties of the DEV UL31 product. The results indicate that DEV UL31 shares many similarities with its HSV or PRV homolog UL31 and suggest that functional cross-complementation is possible between members of the

Whose "Jihad"? Oral History of an American Muslim Educational Leader and U.S. Public Schools

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Ezzani, Miriam D.; King, Kelley M.

2018-01-01

While case studies have documented how teachers can either ameliorate or exacerbate situations of ignorance or hate in the classroom toward Muslim students, the role of educational leaders in U.S. public schools remains negligible. In response, this paper aims to develop the knowledge base of educational leadership as it pertains to the jihad or…

Involvement of UL24 in herpes-simplex-virus-1-induced dispersal of nucleolin

International Nuclear Information System (INIS)

Lymberopoulos, Maria H.; Pearson, Angela

2007-01-01

UL24 of herpes simplex virus 1 is important for efficient viral replication, but its function is unknown. We generated a recombinant virus, vHA-UL24, encoding UL24 with an N-terminal hemagglutinin tag. By indirect immunofluorescence at 9 h post-infection (hpi), we detected HA-UL24 in nuclear foci and in cytoplasmic speckles. HA-UL24 partially co-localized with nucleolin, but not with ICP8 or coilin, markers for nucleoli, viral replication compartments, and Cajal bodies respectively. HA-UL24 staining was often juxtaposed to that of another nucleolar protein, fibrillarin. Analysis of HSV-1-induced nucleolar modifications revealed that by 18 hpi, nucleolin staining had dispersed, and fibrillarin staining went from clusters of small spots to a few separate but prominent spots. Fibrillarin redistribution appeared to be independent of UL24. In contrast, cells infected with a UL24-deficient virus retained foci of nucleolin staining. Our results demonstrate involvement of UL24 in dispersal of nucleolin during infection

Identification and characterization of the pseudorabies virus UL43 protein

International Nuclear Information System (INIS)

Klupp, Barbara G.; Altenschmidt, Jan; Granzow, Harald; Fuchs, Walter; Mettenleiter, Thomas C.

2005-01-01

Among the least characterized herpesvirus membrane proteins are the homologs of UL43 of herpes simplex virus 1 (HSV-1). To identify and characterize the UL43 protein of pseudorabies virus (PrV), part of the open reading frame was expressed in Escherichia coli and used for immunization of a rabbit. The antiserum recognized in Western blots a 34-kDa protein in lysates of PrV infected cells and purified virions, demonstrating that the UL43 protein is a virion component. In indirect immunofluorescence analysis, the antiserum labeled vesicular structures in PrV infected cells which also contained glycoprotein B. To functionally analyze UL43, a deletion mutant was constructed lacking amino acids 23-332 of the 373aa protein. This mutant was only slightly impaired in replication as assayed by one-step growth kinetics, measurement of plaque sizes, and electron microscopy. Interestingly, the PrV UL43 protein was able to inhibit fusion induced by PrV glycoproteins in a transient expression-fusion assay to a similar extent as gM. Double mutant viruses lacking, in addition to UL43, the multiply membrane spanning glycoproteins K or M did not show a phenotype beyond that observed in the gK and gM single deletion mutants

Identification of interaction domains within the UL37 tegument protein of herpes simplex virus type 1.

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Bucks, Michelle A; Murphy, Michael A; O'Regan, Kevin J; Courtney, Richard J

2011-07-20

Herpes simplex virus type 1 (HSV-1) UL37 is a 1123 amino acid tegument protein that self-associates and binds to the tegument protein UL36 (VP1/2). Studies were undertaken to identify regions of UL37 involved in these protein-protein interactions. Coimmunoprecipitation assays showed that residues within the carboxy-terminal half of UL37, amino acids 568-1123, are important for interaction with UL36. Coimmunoprecipitation assays also revealed that amino acids 1-300 and 568-1123 of UL37 are capable of self-association. UL37 appears to self-associate only under conditions when UL36 is not present or is present in low amounts, suggesting UL36 and UL37 may compete for binding. Transfection-infection experiments were performed to identify domains of UL37 that complement the UL37 deletion virus, K∆UL37. The carboxy-terminal region of UL37 (residues 568-1123) partially rescues the K∆UL37 infection. These results suggest the C-terminus of UL37 may contribute to its essential functional role within the virus-infected cell. Copyright © 2011 Elsevier Inc. All rights reserved.

Towards Global Jihadism: Al-Qaeda's Strategic, Ideological and Structural Adaptations since 9/11

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Bill Braniff

2011-05-01

Full Text Available In recent years, Al-Qaeda has suffered a number of setbacks, but has also successfully spawned an expansionist global jihadist movement that will survive the death of Osama bin Laden. This article describes how the multifaceted threat posed by global jihadism has evolved over the last decade. It first recounts some of the more salient examples of Al-Qaeda’s post-9/11 strategic, ideological, and structural adaptations, and then offers a balance sheet of Al-Qaeda’s contemporary strengths and weaknesses. Al-Qaeda continues to enable the violence of others, orient that violence towards the United States and its allies in a distributed game of attrition warfare, and foster a dichotomous “us versus them” narrative between the Muslim world and the rest of the international community. Despite this overarching consistency, Al-Qaeda shepherds a different phenomenon than it did ten years ago. The aggregation of the movement’s strategic, ideological, and structural adaptations has fundamentally changed the nature of the jihadist threat to the West. This evolved threat is not inherently more dangerous, as counterterrorism efforts today focus on and disrupt capability earlier and more consistently than prior to September 2001. This multifaceted global jihad will, however, continue to produce greater numbers of attacks in more locations, from a more diverse cadre of individuals spanning a wider ideological spectrum.   

Human Cytomegalovirus pUL47 Modulates Tegumentation and Capsid Accumulation at the Viral Assembly Complex

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Cappadona, Ilaria; Villinger, Clarissa; Schutzius, Gabi; Mertens, Thomas

2015-01-01

ABSTRACT Human cytomegalovirus (HCMV) tegument protein pUL47 is an interaction partner of pUL48 and highly conserved among herpesviruses. It is closely associated with the capsid and has an important function early in infection. Here, we report a specific role of pUL47 in the tegumentation of capsids in the cytoplasm. A newly generated mutant virus (TB-47stop), in which expression of pUL47 is blocked, exhibited a severe impairment in cell-to-cell spread and release of infectivity from infected cells. Ultrastructural analysis of TB-47stop-infected cells clearly showed cytoplasmic accumulations of nonenveloped capsids that were only partially tegumented, indicating that these capsids failed to complete tegumentation. Nevertheless, these accumulations were positive for HCMV inner tegument proteins pp150 and pUL48, suggesting that their attachment to capsids occurs independently of pUL47. Despite these morphological alterations, fully enveloped virus particles were found in the extracellular space and at the viral assembly complex (vAC) of TB-47stop-infected cells, indicating that pUL47 is not essential for the generation of virions. We confirmed findings that incorporation of pUL48 into virions is impaired in the absence of pUL47. Interestingly, pUL47 exhibited a strong nuclear localization in transfected cells, whereas it was found exclusively at the vAC in the context of virus infection. Colocalization of pUL47 and pUL48 at the vAC is consistent with their interaction. We also found a shift to a more nuclear localization of pUL47 when the expression of pUL48 was reduced. Summarizing our results, we hypothesize that pUL48 directs pUL47 to the vAC to promote tegumentation and secondary envelopment of capsids. IMPORTANCE Generation of infectious HCMV particles requires an organized and multistep process involving the action of several viral and cellular proteins as well as protein-protein interactions. A better understanding of these processes is important for

PENDIDIKAN ISLAMI DALAM NILAI-NILAI KEARIFAN LOKAL DIDONG

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Eliyyil Akbar

2015-08-01

�رثت من الاجداد ويعيثون مخّ تربية الاسلام كوسيلة فنّ الغناء الإقْليمي وبذلك المهم جداً، طلب حلّ المشكلة إتخد موقفا ايجابياً في تلك المسئلة. فنّ الغناء الإقليمي تملك عنصر الجمال، الدين والوحدة "موكميل، ترتيب، ستيّي، سماياع كماسيه، موتنتو، امنة، كناف مفاكة، الاع تولوغ، برسيككميلين". قيم الإسلامي من فن الغناء الإقليمي لا تخلوْ من العادة والشريعة ويمتصّها مجتمع وبذلك صفة التسامح التي قد بنيت جعلت الأمن والمخّ الإسلامي كمنطقة منفذة شريعة الإسلامي.Abstrak: Terancamnya identitas bangsa Indonesia yang bersemboyan Bhinneka Tunggal Ika dengan munculnya konflik antar suku, agama, ras, kekerasan yang menjadi ajang perpecahan persatuan bangsa ini. Peristiwa tersebut tercipta karena pudarnya sikap toleran yang termanifestasikan dalam Islam yang rahmatan lil ‘alamin dan tidak mengindahkan kearifan yang sudah terbina. Di tengah maraknya perpecahan tersebut, daerah dataran tinggi Gayo yang merupakan daerah penegak syari’at Islam yang didiami oleh berbagai suku mampu menetralisir keadaan dengan mempertahankan nilai yang arif dari peninggalan leluhur  dan menghidupkan suasana pendidikan Islami menggunakan sarana atau media seni Didong. Oleh karena itu, pentingnya solusi untuk menyikapi suatu perbedaan yang rentan menimbulkan konflik dengan menjunjung kearifan lokal. Nilai seni Didong berunsur keindahan, religius dan kebersamaan yang tertransformasi dari pesan kebijaksanan lokal, yaitu mukemel, tertib, setie, semayang-gemasih, mutentu, amanah, genap-mupakat, alang-tulung, dan bersikekemelen. Pendidikan Islami dari pertunjukan Didong tidak lepas dari adat, syari’at, dan lebih bisa diserap oleh masyarakat dengan begitu sifat

INDONESIAN SALAFISM ON JIHAD AND SUICIDE BOMBINGS

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Rusli Rusli

2014-06-01

Full Text Available This paper deals with jihad and suicide bombings from the perspective of Indonesian salafism. It is argued that there are two different points of view related to this issue. The first is those who are affiliated with Wahhabi salafists such as those involved in Salafi-based foundations like As-Sunnah, Ihyaut Turats, al-Sofwah, Lajnah al-Khairiyah, Lajnah al-Istiqamah, and Wahdah Islamiyyah. They do not agree with suicide bombing directed to Western targets—mainly America—and its symbols. Suicide bombings are equivalent to killing oneself, and this is extremely forbidden in Islam. The second is Salafi-jihadists who have justified suicide bombing attacks to infidel targets and the symbols of tagut (false god. The reason is blowing oneself is not the same as committing suicide, for suicide is a sin. However, he is believed as carrying out “martyrdom operations”, sacrificing himself for the sake of the superior goal of defending his religion and community, while suicide is a hopeless deed performed by a person who kills himself for his own selfish reason.

Whose Hearts and Minds? Narratives and Counter-Narratives of Salafi Jihadism

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Dina Al Raffie

2012-09-01

Full Text Available Since the advent of the Global War on Terror, the world has witnessed the continuation of terrorist activity under the banner of Salafi Jihad. With military action proving insufficient to defeat the propagators of the ideology, attention has turned to the ideology itself. Understanding the narratives that constitute this ideology and the systems in place that help propagate it is crucial to defeating it. Analysis brings to light elements that arguably constitute a Jihadist master narrative as well as support structures that help perpetuate key underlying messages of this master narrative. Successful counter-narratives should focus on rolling back and containing Jihadist narratives whilst simultaneously highlighting the values and attitudes of democratic, free societies

Interaction and interdependent packaging of tegument protein UL11 and glycoprotein e of herpes simplex virus.

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Han, Jun; Chadha, Pooja; Meckes, David G; Baird, Nicholas L; Wills, John W

2011-09-01

The UL11 tegument protein of herpes simplex virus plays a critical role in the secondary envelopment; however, the mechanistic details remain elusive. Here, we report a new function of UL11 in the budding process in which it directs efficient acquisition of glycoprotein E (gE) via a direct interaction. In vitro binding assays showed that the interaction required only the first 28, membrane-proximal residues of the cytoplasmic tail of gE, and the C-terminal 26 residues of UL11. A second, weaker binding site was also found in the N-terminal half of UL11. The significance of the gE-UL11 interaction was subsequently investigated with viral deletion mutants. In the absence of the gE tail, virion packaging of UL11, but not other tegument proteins such as VP22 and VP16, was reduced by at least 80%. Reciprocally, wild-type gE packaging was also drastically reduced by about 87% in the absence of UL11, and this defect could be rescued in trans by expressing U(L)11 at the U(L)35 locus. Surprisingly, a mutant that lacks the C-terminal gE-binding site of UL11 packaged nearly normal amounts of gE despite its strong interaction with the gE tail in vitro, indicating that the interaction with the UL11 N terminus may be important. Mutagenesis studies of the UL11 N terminus revealed that the association of UL11 with membrane was not required for this function. In contrast, the UL11 acidic cluster motif was found to be critical for gE packaging and was not replaceable with foreign acidic clusters. Together, these results highlight an important role of UL11 in the acquisition of glycoprotein-enriched lipid bilayers, and the findings may also have important implications for the role of UL11 in gE-mediated cell-to-cell spread.

The Cyclin-Dependent Kinase Ortholog pUL97 of Human Cytomegalovirus Interacts with Cyclins

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Laura Graf

2013-12-01

Full Text Available The human cytomegalovirus (HCMV-encoded protein kinase, pUL97, is considered a cyclin-dependent kinase (CDK ortholog, due to shared structural and functional characteristics. The primary mechanism of CDK activation is binding to corresponding cyclins, including cyclin T1, which is the usual regulatory cofactor of CDK9. This study provides evidence of direct interaction between pUL97 and cyclin T1 using yeast two-hybrid and co-immunoprecipitation analyses. Confocal immunofluorescence revealed partial colocalization of pUL97 with cyclin T1 in subnuclear compartments, most pronounced in viral replication centres. The distribution patterns of pUL97 and cyclin T1 were independent of HCMV strain and host cell type. The sequence domain of pUL97 responsible for the interaction with cyclin T1 was between amino acids 231–280. Additional co-immunoprecipitation analyses showed cyclin B1 and cyclin A as further pUL97 interaction partners. Investigation of the pUL97-cyclin T1 interaction in an ATP consumption assay strongly suggested phosphorylation of pUL97 by the CDK9/cyclin T1 complex in a substrate concentration-dependent manner. This is the first demonstration of interaction between a herpesviral CDK ortholog and cellular cyclins.

Identification of conserved amino acids in the herpes simplex virus type 1 UL8 protein required for DNA synthesis and UL52 primase interaction in the virus replisome.

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Muylaert, Isabella; Zhao, Zhiyuan; Andersson, Torbjörn; Elias, Per

2012-09-28

We have used oriS-dependent transient replication assays to search for species-specific interactions within the herpes simplex virus replisome. Hybrid replisomes derived from herpes simplex virus type 1 (HSV-1) and equine herpesvirus type 1 (EHV-1) failed to support DNA replication in cells. Moreover, the replisomes showed a preference for their cognate origin of replication. The results demonstrate that the herpesvirus replisome behaves as a molecular machine relying on functionally important interactions. We then searched for functional interactions in the replisome context by subjecting HSV-1 UL8 protein to extensive mutagenesis. 52 mutants were made by replacing single or clustered charged amino acids with alanines. Four mutants showed severe replication defects. Mutant A23 exhibited a lethal phenotype, and mutants A49, A52 and A53 had temperature-sensitive phenotypes. Mutants A49 and A53 did not interact with UL52 primase as determined by co-immunoprecipitation experiments. Using GFP-tagged UL8, we demonstrate that all mutants were unable to support formation of ICP8-containing nuclear replication foci. Extended mutagenesis suggested that a highly conserved motif corresponding to mutant A49 serves an important role for establishing a physical contact between UL8 and UL52. The replication-defective mutations affected conserved amino acids, and similar phenotypes were observed when the corresponding mutations were introduced into EHV-1 UL8.

Structural changes in human cytomegalovirus cytoplasmic assembly sites in the absence of UL97 kinase activity

International Nuclear Information System (INIS)

Azzeh, Maysa; Honigman, Alik; Taraboulos, Albert; Rouvinski, Alexander; Wolf, Dana G.

2006-01-01

Studies of human cytomegalovirus (HCMV) UL97 kinase deletion mutant (ΔUL97) indicated a multi-step role for this kinase in early and late phases of the viral life cycle, namely, in DNA replication, capsid maturation and nuclear egress. Here, we addressed its possible involvement in cytoplasmic steps of HCMV assembly. Using the ΔUL97 and the UL97 kinase inhibitor NGIC-I, we demonstrate that the absence of UL97 kinase activity results in a modified subcellular distribution of the viral structural protein assembly sites, from compact structures impacting upon the nucleus to diffuse perinuclear structures punctuated by large vacuoles. Infection by either wild type or ΔUL97 viruses induced a profound reorganization of wheat germ agglutinin (WGA)-positive Golgi-related structures. Importantly, the viral-induced Golgi remodeling along with the reorganization of the nuclear architecture was substantially altered in the absence of UL97 kinase activity. These findings suggest that UL97 kinase activity might contribute to organization of the viral cytoplasmic assembly sites

pUL34 binding near the human cytomegalovirus origin of lytic replication enhances DNA replication and viral growth.

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Slayton, Mark; Hossain, Tanvir; Biegalke, Bonita J

2018-05-01

The human cytomegalovirus (HCMV) UL34 gene encodes sequence-specific DNA-binding proteins (pUL34) which are required for viral replication. Interactions of pUL34 with DNA binding sites represses transcription of two viral immune evasion genes, US3 and US9. 12 additional predicted pUL34-binding sites are present in the HCMV genome (strain AD169) with three binding sites concentrated near the HCMV origin of lytic replication (oriLyt). We used ChIP-seq analysis of pUL34-DNA interactions to confirm that pUL34 binds to the oriLyt region during infection. Mutagenesis of the UL34-binding sites in an oriLyt-containing plasmid significantly reduced viral-mediated oriLyt-dependent DNA replication. Mutagenesis of these sites in the HCMV genome reduced the replication efficiencies of the resulting viruses. Protein-protein interaction analyses demonstrated that pUL34 interacts with the viral proteins IE2, UL44, and UL84, that are essential for viral DNA replication, suggesting that pUL34-DNA interactions in the oriLyt region are involved in the DNA replication cascade. Copyright © 2018 Elsevier Inc. All rights reserved.

Analisis dan Perancangan Sistem Informasi Penjualan dan Persediaan pada PT Nur Islami Tour and Travel

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Titan Titan

2012-06-01

Full Text Available The analysis and design of sales and inventory information system performed at PT Nur Islami is aimed to identify the organization needs to control and manage the data and information of operational transaction. The result will be used as a base for developing a new computerized system. The activity in analysis and design is focused in sales and inventory activities, which is the main core of the organization. These needs will be documented using unified modeling language. The C# and SQL Server 2005 will be used to design and develop the application and database for fulfilling the needs. This information system will ease the organization in doing their activity in selling and monitoring the stock. On the other hand, it will also minimize the data lost, which is usually caused by the conservative storage mechanism of transactional data.

End-joining inhibition at telomeres requires the translocase and polySUMO-dependent ubiquitin ligase Uls1.

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Lescasse, Rachel; Pobiega, Sabrina; Callebaut, Isabelle; Marcand, Stéphane

2013-03-20

In eukaryotes, permanent inhibition of the non-homologous end joining (NHEJ) repair pathway at telomeres ensures that chromosome ends do not fuse. In budding yeast, binding of Rap1 to telomere repeats establishes NHEJ inhibition. Here, we show that the Uls1 protein is required for the maintenance of NHEJ inhibition at telomeres. Uls1 protein is a non-essential Swi2/Snf2-related translocase and a Small Ubiquitin-related Modifier (SUMO)-Targeted Ubiquitin Ligase (STUbL) with unknown targets. Loss of Uls1 results in telomere-telomere fusions. Uls1 requirement is alleviated by the absence of poly-SUMO chains and by rap1 alleles lacking SUMOylation sites. Furthermore, Uls1 limits the accumulation of Rap1 poly-SUMO conjugates. We propose that one of Uls1 functions is to clear non-functional poly-SUMOylated Rap1 molecules from telomeres to ensure the continuous efficiency of NHEJ inhibition. Since Uls1 is the only known STUbL with a translocase activity, it can be the general molecular sweeper for the clearance of poly-SUMOylated proteins on DNA in eukaryotes.

Resistance to maribavir is associated with the exclusion of pUL27 from nucleoli during human cytomegalovirus infection

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Hakki, Morgan; Drummond, Coyne; Houser, Benjamin; Marousek, Gail; Chou, Sunwen

2011-01-01

Select mutations in the human cytomegalovirus (HCMV) gene UL27 confer low-grade resistance to the HCMV UL97 kinase inhibitor maribavir (MBV). It has been reported that the 608-amino acid UL27 gene product (pUL27) normally localizes to cell nuclei and nucleoli, whereas its truncation at codon 415, as found in a MBV-resistant mutant, results in cytoplasmic localization. We now show that in the context of full-length pUL27, diverse single amino acid substitutions associated with MBV resistance result in loss of its nucleolar localization when visualized after transient transfection, whereas substitutions representing normal interstrain polymorphism had no such effect. The same differences in localization were observed during a complete infection cycle with recombinant HCMV strains over-expressing full-length fluorescent pUL27 variants. Nested UL27 C-terminal truncation expression plasmids showed that amino acids 596–599 were required for the nucleolar localization of pUL27. These results indicate that the loss of a nucleolar function of pUL27 may contribute to MBV resistance, and that the nucleolar localization of pUL27 during HCMV infection depends not only on a carboxy-terminal domain but also on a property of pUL27 that is affected by MBV-resistant mutations, such as an interaction with component(s) of the nucleolus. PMID:21906628

Screening and identification of host factors interacting with UL14 of herpes simplex virus 1.

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Wu, Fuqing; Xing, Junji; Wang, Shuai; Li, Meili; Zheng, Chunfu

2011-08-01

The UL14 protein of herpes simplex virus type 1 (HSV-1) is highly conserved in herpesvirus family. However, its exact function during the HSV-1 replication cycle is little known. In the present study, a high throughput yeast two-hybrid system was employed to screen the cellular factors interacting with UL14, and five target candidates were yielded: (1) TSC22 domain family protein 3 (TSC22D3); (2) Mediator of RNA polymerase II transcription subunit 8 isoform 1(MED8); (3) Runt-related transcription factor 3 (RUNX3); (4) Arrestin beta-2 (ARRB2); (5) Cereblon (CRBN). Indirect immunofluorescent assay showed that both TSC22D3 and MED8 co-localized with UL14. Co-immunoprecipitation assay demonstrated that UL14 could be immunoprecipitated by TSC22D3, suggesting that UL14 interacted with TSC22D3 under physiological condition. In summary, this study opened up new avenues toward delineating the function and physiological significance of UL14 during the HSV-1 replication cycle.

The structure of cytomegalovirus immune modulator UL141 highlights structural Ig-fold versatility for receptor binding

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Nemčovičová, Ivana [La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037 (United States); Slovak Academy of Sciences, Dúbravská cesta 9, SK 84505 Bratislava (Slovakia); Zajonc, Dirk M., E-mail: dzajonc@liai.org [La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037 (United States)

2014-03-01

The crystal structure of Human cytomegalovirus immune modulator UL141 was solved at 3.25 Å resolution. Here, a detailed analysis of its intimate dimerization interface and the biophysical properties of its receptor (TRAIL-R2 and CD155) binding interactions are presented. Natural killer (NK) cells are critical components of the innate immune system as they rapidly detect and destroy infected cells. To avoid immune recognition and to allow long-term persistence in the host, Human cytomegalovirus (HCMV) has evolved a number of genes to evade or inhibit immune effector pathways. In particular, UL141 can inhibit cell-surface expression of both the NK cell-activating ligand CD155 as well as the TRAIL death receptors (TRAIL-R1 and TRAIL-R2). The crystal structure of unliganded HCMV UL141 refined to 3.25 Å resolution allowed analysis of its head-to-tail dimerization interface. A ‘dimerization-deficient’ mutant of UL141 (ddUL141) was further designed, which retained the ability to bind to TRAIL-R2 or CD155 while losing the ability to cross-link two receptor monomers. Structural comparison of unliganded UL141 with UL141 bound to TRAIL-R2 further identified a mobile loop that makes intimate contacts with TRAIL-R2 upon receptor engagement. Superposition of the Ig-like domain of UL141 on the CD155 ligand T-cell immunoreceptor with Ig and ITIM domains (TIGIT) revealed that UL141 can potentially engage CD155 similar to TIGIT by using the C′C′′ and GF loops. Further mutations in the TIGIT binding site of CD155 (Q63R and F128R) abrogated UL141 binding, suggesting that the Ig-like domain of UL141 is a viral mimic of TIGIT, as it targets the same binding site on CD155 using similar ‘lock-and-key’ interactions. Sequence alignment of the UL141 gene and its orthologues also showed conservation in this highly hydrophobic (L/A)X{sub 6}G ‘lock’ motif for CD155 binding as well as conservation of the TRAIL-R2 binding patches, suggesting that these host�

The structure of cytomegalovirus immune modulator UL141 highlights structural Ig-fold versatility for receptor binding

International Nuclear Information System (INIS)

Nemčovičová, Ivana; Zajonc, Dirk M.

2014-01-01

The crystal structure of Human cytomegalovirus immune modulator UL141 was solved at 3.25 Å resolution. Here, a detailed analysis of its intimate dimerization interface and the biophysical properties of its receptor (TRAIL-R2 and CD155) binding interactions are presented. Natural killer (NK) cells are critical components of the innate immune system as they rapidly detect and destroy infected cells. To avoid immune recognition and to allow long-term persistence in the host, Human cytomegalovirus (HCMV) has evolved a number of genes to evade or inhibit immune effector pathways. In particular, UL141 can inhibit cell-surface expression of both the NK cell-activating ligand CD155 as well as the TRAIL death receptors (TRAIL-R1 and TRAIL-R2). The crystal structure of unliganded HCMV UL141 refined to 3.25 Å resolution allowed analysis of its head-to-tail dimerization interface. A ‘dimerization-deficient’ mutant of UL141 (ddUL141) was further designed, which retained the ability to bind to TRAIL-R2 or CD155 while losing the ability to cross-link two receptor monomers. Structural comparison of unliganded UL141 with UL141 bound to TRAIL-R2 further identified a mobile loop that makes intimate contacts with TRAIL-R2 upon receptor engagement. Superposition of the Ig-like domain of UL141 on the CD155 ligand T-cell immunoreceptor with Ig and ITIM domains (TIGIT) revealed that UL141 can potentially engage CD155 similar to TIGIT by using the C′C′′ and GF loops. Further mutations in the TIGIT binding site of CD155 (Q63R and F128R) abrogated UL141 binding, suggesting that the Ig-like domain of UL141 is a viral mimic of TIGIT, as it targets the same binding site on CD155 using similar ‘lock-and-key’ interactions. Sequence alignment of the UL141 gene and its orthologues also showed conservation in this highly hydrophobic (L/A)X 6 G ‘lock’ motif for CD155 binding as well as conservation of the TRAIL-R2 binding patches, suggesting that these host–receptor interactions

78 FR 28812 - Energy Efficiency Program for Industrial Equipment: Petition of UL Verification Services Inc. for...

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2013-05-16

... are engineers. UL today is comprised of five businesses, Product Safety, Verification Services, Life..., Director--Global Technical Research, UL Verification Services. Subscribed and sworn to before me this 20... (431.447(c)(4)) General Personnel Overview UL is a global independent safety science company with more...

Breaking the Waves: How the Phenomenon of European Jihadism Militates Against the Wave Theory of Terrorism

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Proshyn Denys

2015-12-01

Full Text Available David Rapoport’s Wave theory of terrorism is one of the most oftencited theories in the literature on terrorist violence. Rapoport is praised for having provided researchers with a universal instrument which allows them to explain the origin and transformation of various historical types of terrorism by applying to them the concept of global waves of terrorist violence driven by universal political impulses. This article, testing the Wave theory against the recent phenomenon of homegrown jihadism in Europe, uncovers this theory’s fundamental weaknesses and questions its real academic and practical value.

Identification of binding domains in the herpes simplex virus type 1 small capsid protein pUL35 (VP26).

Science.gov (United States)

Apcarian, Arin; Cunningham, Anthony L; Diefenbach, Russell J

2010-11-01

In this study, fragments of the small capsid protein pUL35 (VP26) from herpes simplex virus type 1 (HSV-1) were generated to identify binding domains for a number of known ligands. Analysis of the binding of dynein light chain subunits, DYNLT1 and DYNLT3, as well the HSV-1 structural proteins pUL19 (VP5) and pUL37 was then undertaken using the LexA yeast two-hybrid assay. The N-terminal half of pUL35, in particular residues 30-43, was identified as a common region for the binding of DYNLT1 and DYNLT3. Additional distinct regions in the C terminus of pUL35 also contribute to the binding of DYNLT1 and DYNLT3. In contrast, only the C-terminal half of pUL35 was found to mediate the binding of pUL19 and pUL37 through distinct regions. The relevance of this information to the role of pUL35 in viral transport and assembly is discussed.

Dynamic and nucleolin-dependent localization of human cytomegalovirus UL84 to the periphery of viral replication compartments and nucleoli.

Science.gov (United States)

Bender, Brian J; Coen, Donald M; Strang, Blair L

2014-10-01

Protein-protein and protein-nucleic acid interactions within subcellular compartments are required for viral genome replication. To understand the localization of the human cytomegalovirus viral replication factor UL84 relative to other proteins involved in viral DNA synthesis and to replicating viral DNA in infected cells, we created a recombinant virus expressing a FLAG-tagged version of UL84 (UL84FLAG) and used this virus in immunofluorescence assays. UL84FLAG localization differed at early and late times of infection, transitioning from diffuse distribution throughout the nucleus to exclusion from the interior of replication compartments, with some concentration at the periphery of replication compartments with newly labeled DNA and the viral DNA polymerase subunit UL44. Early in infection, UL84FLAG colocalized with the viral single-stranded DNA binding protein UL57, but colocalization became less prominent as infection progressed. A portion of UL84FLAG also colocalized with the host nucleolar protein nucleolin at the peripheries of both replication compartments and nucleoli. Small interfering RNA (siRNA)-mediated knockdown of nucleolin resulted in a dramatic elimination of UL84FLAG from replication compartments and other parts of the nucleus and its accumulation in the cytoplasm. Reciprocal coimmunoprecipitation of viral proteins from infected cell lysates revealed association of UL84, UL44, and nucleolin. These results indicate that UL84 localization during infection is dynamic, which is likely relevant to its functions, and suggest that its nuclear and subnuclear localization is highly dependent on direct or indirect interactions with nucleolin. Importance: The protein-protein interactions among viral and cellular proteins required for replication of the human cytomegalovirus (HCMV) DNA genome are poorly understood. We sought to understand how an enigmatic HCMV protein critical for virus replication, UL84, localizes relative to other viral and cellular

Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA

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Dixon Melissa

2005-07-01

Full Text Available Abstract Background Human cytomegalovirus UL114 encodes a uracil-DNA glycosylase homolog that is highly conserved in all characterized herpesviruses that infect mammals. Previous studies demonstrated that the deletion of this nonessential gene delays significantly the onset of viral DNA synthesis and results in a prolonged replication cycle. The gene product, pUL114, also appears to be important in late phase DNA synthesis presumably by introducing single stranded breaks. Results A series of experiments was performed to formally assign the observed phenotype to pUL114 and to characterize the function of the protein in viral replication. A cell line expressing pUL114 complemented the observed phenotype of a UL114 deletion virus in trans, confirming that the observed defects were the result of a deficiency in this gene product. Stocks of recombinant viruses without elevated levels of uracil were produced in the complementing cells; however they retained the phenotype of poor growth in normal fibroblasts suggesting that poor replication was unrelated to uracil content of input genomes. Recombinant viruses expressing epitope tagged versions of this gene demonstrated that pUL114 was expressed at early times and that it localized to viral replication compartments. This protein also coprecipitated with the DNA polymerase processivity factor, ppUL44 suggesting that these proteins associate in infected cells. This apparent interaction did not appear to require other viral proteins since ppUL44 could recruit pUL114 to the nucleus in uninfected cells. An analysis of DNA replication kinetics revealed that the initial rate of DNA synthesis and the accumulation of progeny viral genomes were significantly reduced compared to the parent virus. Conclusion These data suggest that pUL114 associates with ppUL44 and that it functions as part of the viral DNA replication complex to increase the efficiency of both early and late phase viral DNA synthesis.

AWI Moored ULS Data, Weddell Sea (1990-1998)

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National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of moored Upward Looking Sonar (ULS) data from 14 stations in the Weddell Sea. Parameters in the processed data files are water pressure,...

Multiple phosphorylation sites at the C-terminus regulate nuclear import of HCMV DNA polymerase processivity factor ppUL44

International Nuclear Information System (INIS)

Alvisi, Gualtiero; Marin, Oriano; Pari, Gregory; Mancini, Manuela; Avanzi, Simone; Loregian, Arianna; Jans, David A.; Ripalti, Alessandro

2011-01-01

The processivity factor of human cytomegalovirus DNA polymerase, phosphoprotein ppUL44, is essential for viral replication. During viral infection ppUL44 is phosphorylated by the viral kinase pUL97, but neither the target residues on ppUL44 nor the effect of phosphorylation on ppUL44's activity are known. We report here that ppUL44 is phosphorylated when transiently expressed in mammalian cells and coimmunoprecipitates with cellular kinases. Of three potential phosphorylation sites (S413, S415, S418) located upstream of ppUL44's nuclear localization signal (NLS) and one (T427) within the NLS itself, protein kinase CK2 (CK2) specifically phosphorylates S413, to trigger a cascade of phosphorylation of S418 and S415 by CK1 and CK2, respectively. Negative charge at the CK2/CK1 target serine residues facilitates optimal nuclear accumulation of ppUL44, whereas negative charge on T427, a potential cyclin-dependent 1 phosphorylation site, strongly decreases nuclear accumulation. Thus, nuclear transport of ppUL44 is finely tuned during viral infection through complex phosphorylation events.

Cyclin A degradation by primate cytomegalovirus protein pUL21a counters its innate restriction of virus replication.

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Nicolas Caffarelli

Full Text Available Cyclin A is critical for cellular DNA synthesis and S phase progression of the cell cycle. Human cytomegalovirus (HCMV can reduce cyclin A levels and block cellular DNA synthesis, and cyclin A overexpression can repress HCMV replication. This interaction has only been previously observed in HCMV as murine CMV does not downregulate cyclin A, and the responsible viral factor has not been identified. We previously reported that the HCMV protein pUL21a disrupted the anaphase-promoting complex (APC, but a point mutant abrogating this activity did not phenocopy a UL21a-deficient virus, suggesting that pUL21a has an additional function. Here we identified a conserved arginine-x-leucine (RxL cyclin-binding domain within pUL21a, which allowed pUL21a to interact with cyclin A and target it for proteasome degradation. Homologous pUL21a proteins from both chimpanzee and rhesus CMVs also contained the RxL domain and similarly degraded cyclin A, indicating that this function is conserved in primate CMVs. The RxL point mutation disabled the virus' ability to block cellular DNA synthesis and resulted in a growth defect similar to pUL21a-deficient virus. Importantly, knockdown of cyclin A rescued growth of UL21a-deficient virus. Together, these data show that during evolution, the pUL21a family proteins of primate CMVs have acquired a cyclin-binding domain that targets cyclin A for degradation, thus neutralizing its restriction on virus replication. Finally, the combined proteasome-dependent degradation of pUL21a and its cellular targets suggests that pUL21a may act as a novel suicide protein, targeting its protein cargos for destruction.

Crystal Structure of the N-Terminal Half of the Traffic Controller UL37 from Herpes Simplex Virus 1

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Koenigsberg, Andrea L.; Heldwein, Ekaterina E.; Sandri-Goldin, Rozanne M.

2017-08-02

Inner tegument protein UL37 is conserved among all three subfamilies of herpesviruses. Studies of UL37 homologs from two alphaherpesviruses, herpes simplex virus 1 (HSV-1) and pseudorabies virus (PRV), have suggested that UL37 plays an essential albeit poorly defined role in intracellular capsid trafficking. At the same time, HSV and PRV homologs cannot be swapped, which suggests that in addition to a conserved function, UL37 homologs also have divergent virus-specific functions. Accurate dissection of UL37 functions requires detailed maps in the form of atomic-resolution structures. Previously, we reported the crystal structure of the N-terminal half of UL37 (UL37N) from PRV. Here, we report the crystal structure of HSV-1 UL37N. Comparison of the two structures reveals that UL37 homologs differ in their overall shapes, distributions of surface charges, and locations of projecting loops. In contrast, the previously identified R2 surface region is structurally conserved. We propose that within the N-terminal half of UL37, functional conservation is centered within the R2 surface region, whereas divergent structural elements pinpoint regions mediating virus-specific functions and may engage different binding partners. Together, the two structures can now serve as templates for a structure-guided exploration of both conserved and virus-specific functions of UL37.

IMPORTANCEThe ability to move efficiently within host cell cytoplasm is essential for replication in all viruses. It is especially important in the neuroinvasive alphaherpesviruses, such as human herpes simplex virus 1 (HSV-1), HSV-2, and veterinarian pseudorabies virus (PRV), that infect the peripheral nervous system and have to travel long distances along axons. Capsid movement in these viruses is controlled by capsid-associated tegument proteins, yet their specific roles have not yet been defined. Systematic exploration of the roles of tegument proteins in capsid trafficking requires

Residues of the UL25 Protein of Herpes Simplex Virus That Are Required for Its Stable Interaction with Capsids ▿

Science.gov (United States)

Cockrell, Shelley K.; Huffman, Jamie B.; Toropova, Katerina; Conway, James F.; Homa, Fred L.

2011-01-01

The herpes simplex virus 1 (HSV-1) UL25 gene product is a minor capsid component that is required for encapsidation, but not cleavage, of replicated viral DNA. UL25 is located on the capsid surface in a proposed heterodimer with UL17, where five copies of the heterodimer are found at each of the capsid vertices. Previously, we demonstrated that amino acids 1 to 50 of UL25 are essential for its stable interaction with capsids. To further define the UL25 capsid binding domain, we generated recombinant viruses with either small truncations or amino acid substitutions in the UL25 N terminus. Studies of these mutants demonstrated that there are two important regions within the capsid binding domain. The first 27 amino acids are essential for capsid binding of UL25, while residues 26 to 39, which are highly conserved in the UL25 homologues of other alphaherpesviruses, were found to be critical for stable capsid binding. Cryo-electron microscopy reconstructions of capsids containing either a small tag on the N terminus of UL25 or the green fluorescent protein (GFP) fused between amino acids 50 and 51 of UL25 demonstrate that residues 1 to 27 of UL25 contact the hexon adjacent to the penton. A second region, most likely centered on amino acids 26 to 39, contacts the triplex that is one removed from the penton. Importantly, both of these UL25 capsid binding regions are essential for the stable packaging of full-length viral genomes. PMID:21411517

Herpes simplex virus type 1 gene UL14: phenotype of a null mutant and identification of the encoded protein.

Science.gov (United States)

Cunningham, C; Davison, A J; MacLean, A R; Taus, N S; Baines, J D

2000-01-01

Herpes simplex virus type 1 (HSV-1) gene UL14 is located between divergently transcribed genes UL13 and UL15 and overlaps the promoters for both of these genes. UL14 also exhibits a substantial overlap of its coding region with that of UL13. It is one of the few HSV-1 genes for which a phenotype and protein product have not been described. Using mass spectrometric and immunological approaches, we demonstrated that the UL14 protein is a minor component of the virion tegument of 32 kDa which is expressed late in infection. In infected cells, the UL14 protein was detected in the nucleus at discrete sites within electron-dense nuclear bodies and in the cytoplasm initially in a diffuse distribution and then at discrete sites. Some of the UL14 protein was phosphorylated. A mutant with a 4-bp deletion in the central region of UL14 failed to produce the UL14 protein and generated small plaques. The mutant exhibited an extended growth cycle at low multiplicity of infection and appeared to be compromised in efficient transit of virus particles from the infected cell. In mice injected intracranially, the 50% lethal dose of the mutant was reduced more than 30,000-fold. Recovery of the mutant from the latently infected sacral ganglia of mice injected peripherally was significantly less than that of wild-type virus, suggesting a marked defect in the establishment of, or reactivation from, latent infection.

Identification of a spliced gene from duck enteritis virus encoding a protein homologous to UL15 of herpes simplex virus 1

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Wang Yu

2011-04-01

Full Text Available Abstract Background In herpesviruses, UL15 homologue is a subunit of terminase complex responsible for cleavage and packaging of the viral genome into pre-assembled capsids. However, for duck enteritis virus (DEV, the causative agent of duck viral enteritis (DVE, the genomic sequence was not completely determined until most recently. There is limited information of this putative spliced gene and its encoding protein. Results DEV UL15 consists of two exons with a 3.5 kilobases (kb inron and transcribes into two transcripts: the full-length UL15 and an N-terminally truncated UL15.5. The 2.9 kb UL15 transcript encodes a protein of 739 amino acids with an approximate molecular mass of 82 kiloDaltons (kDa, whereas the UL15.5 transcript is 1.3 kb in length, containing a putative 888 base pairs (bp ORF that encodes a 32 kDa product. We also demonstrated that UL15 gene belonged to the late kinetic class as its expression was sensitive to cycloheximide and phosphonoacetic acid. UL15 is highly conserved within the Herpesviridae, and contains Walker A and B motifs homologous to the catalytic subunit of the bacteriophage terminase as revealed by sequence analysis. Phylogenetic tree constructed with the amino acid sequences of 23 herpesvirus UL15 homologues suggests a close relationship of DEV to the Mardivirus genus within the Alphaherpesvirinae. Further, the UL15 and UL15.5 proteins can be detected in the infected cell lysate but not in the sucrose density gradient-purified virion when reacting with the antiserum against UL15. Within the CEF cells, the UL15 and/or UL15.5 localize(s in the cytoplasm at 6 h post infection (h p. i. and mainly in the nucleus at 12 h p. i. and at 24 h p. i., while accumulate(s in the cytoplasm in the absence of any other viral protein. Conclusions DEV UL15 is a spliced gene that encodes two products encoded by 2.9 and 1.3 kb transcripts respectively. The UL15 is expressed late during infection. The coding sequences of DEV UL15

Identification of a spliced gene from duck enteritis virus encoding a protein homologous to UL15 of herpes simplex virus 1.

Science.gov (United States)

Zhu, Hongwei; Li, Huixin; Han, Zongxi; Shao, Yuhao; Wang, Yu; Kong, Xiangang

2011-04-06

In herpesviruses, UL15 homologue is a subunit of terminase complex responsible for cleavage and packaging of the viral genome into pre-assembled capsids. However, for duck enteritis virus (DEV), the causative agent of duck viral enteritis (DVE), the genomic sequence was not completely determined until most recently. There is limited information of this putative spliced gene and its encoding protein. DEV UL15 consists of two exons with a 3.5 kilobases (kb) inron and transcribes into two transcripts: the full-length UL15 and an N-terminally truncated UL15.5. The 2.9 kb UL15 transcript encodes a protein of 739 amino acids with an approximate molecular mass of 82 kiloDaltons (kDa), whereas the UL15.5 transcript is 1.3 kb in length, containing a putative 888 base pairs (bp) ORF that encodes a 32 kDa product. We also demonstrated that UL15 gene belonged to the late kinetic class as its expression was sensitive to cycloheximide and phosphonoacetic acid. UL15 is highly conserved within the Herpesviridae, and contains Walker A and B motifs homologous to the catalytic subunit of the bacteriophage terminase as revealed by sequence analysis. Phylogenetic tree constructed with the amino acid sequences of 23 herpesvirus UL15 homologues suggests a close relationship of DEV to the Mardivirus genus within the Alphaherpesvirinae. Further, the UL15 and UL15.5 proteins can be detected in the infected cell lysate but not in the sucrose density gradient-purified virion when reacting with the antiserum against UL15. Within the CEF cells, the UL15 and/or UL15.5 localize(s) in the cytoplasm at 6 h post infection (h p. i.) and mainly in the nucleus at 12 h p. i. and at 24 h p. i., while accumulate(s) in the cytoplasm in the absence of any other viral protein. DEV UL15 is a spliced gene that encodes two products encoded by 2.9 and 1.3 kb transcripts respectively. The UL15 is expressed late during infection. The coding sequences of DEV UL15 are very similar to those of alphaherpesviruses and

Inhibition of Human Cytomegalovirus pUL89 Terminase Subunit Blocks Virus Replication and Genome Cleavage.

Science.gov (United States)

Wang, Yan; Mao, Lili; Kankanala, Jayakanth; Wang, Zhengqiang; Geraghty, Robert J

2017-02-01

The human cytomegalovirus terminase complex cleaves concatemeric genomic DNA into unit lengths during genome packaging and particle assembly. This process is an attractive drug target because cleavage of concatemeric DNA is not required in mammalian cell DNA replication, indicating that drugs targeting the terminase complex could be safe and selective. One component of the human cytomegalovirus terminase complex, pUL89, provides the endonucleolytic activity for genome cleavage, and the domain responsible is reported to have an RNase H-like fold. We hypothesize that the pUL89 endonuclease activity is inhibited by known RNase H inhibitors. Using a novel enzyme-linked immunosorbent assay (ELISA) format as a screening assay, we found that a hydroxypyridonecarboxylic acid compound, previously reported to be an inhibitor of human immunodeficiency virus RNase H, inhibited pUL89 endonuclease activity at low-micromolar concentrations. Further characterization revealed that this pUL89 endonuclease inhibitor blocked human cytomegalovirus replication at a relatively late time point, similarly to other reported terminase complex inhibitors. Importantly, this inhibitor also prevented the cleavage of viral genomic DNA in infected cells. Taken together, these results substantiate our pharmacophore hypothesis and validate our ligand-based approach toward identifying novel inhibitors of pUL89 endonuclease. Human cytomegalovirus infection in individuals lacking a fully functioning immune system, such as newborns and transplant patients, can have severe and debilitating consequences. The U.S. Food and Drug Administration-approved anti-human cytomegalovirus drugs mainly target the viral polymerase, and resistance to these drugs has appeared. Therefore, anti-human cytomegalovirus drugs from novel targets are needed for use instead of, or in combination with, current polymerase inhibitors. pUL89 is a viral ATPase and endonuclease and is an attractive target for anti-human cytomegalovirus

The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel

DEFF Research Database (Denmark)

Wekselman, Itai; Zimmerman, Ella; Davidovich, Chen

2017-01-01

Erythromycin is a clinically useful antibiotic that binds to an rRNA pocket in the ribosomal exit tunnel. Commonly, resistance to erythromycin is acquired by alterations of rRNA nucleotides that interact with the drug. Mutations in the β hairpin of ribosomal protein uL22, which is rather distal...... of the β hairpin of the mutated uL22 toward the interior of the exit tunnel, triggering a cascade of structural alterations of rRNA nucleotides that propagate to the erythromycin binding pocket. Our findings support recent studies showing that the interactions between uL22 and specific sequences within...

Analysis of the herpes simplex virus type 1 UL6 gene in patients with stromal keratitis

International Nuclear Information System (INIS)

Ellison, Aaron R.; Yang Li; Cevallos, A. Vicky; Margolis, Todd P.

2003-01-01

Recent work suggests that herpes simplex virus (HSV) stromal keratitis in the mouse is caused by autoreactive T lymphocytes triggered by a 16 amino acid region of the HSV UL6 protein (aa299-314) , Science 279, 1344-1347). In the present study we sought to determine whether genetic variation of this presumed autoreactive UL6 epitope is responsible for different pathogenic patterns of human HSV keratitis. To accomplish this, we sequenced the HSV UL6 gene from ocular isolates of 10 patients with necrotizing stromal keratitis, 7 patients with recurrent epithelial keratitis, and 8 patients with other forms of HSV keratitis. The sequences obtained predicted identical UL6(299-314) epitopes for all 25 viral isolates. Furthermore, the upstream sequence of all isolates was free of insertions, deletions, and stop codons. We conclude that different pathogenic patterns of human HSV keratitis occur independent of genetic variation of the HSV UL6 (299-314) epitope

Identification of host cell proteins which interact with herpes simplex virus type 1 tegument protein pUL37.

Science.gov (United States)

Kelly, Barbara J; Diefenbach, Eve; Fraefel, Cornel; Diefenbach, Russell J

2012-01-20

The herpes simplex virus type 1 (HSV-1) structural tegument protein pUL37, which is conserved across the Herpesviridae family, is known to be essential for secondary envelopment during the egress of viral particles. To shed light on additional roles of pUL37 during viral replication a yeast two-hybrid screen of a human brain cDNA library was undertaken. This screen identified ten host cell proteins as potential pUL37 interactors. One of the interactors, serine threonine kinase TAOK3, was subsequently confirmed to interact with pUL37 using an in vitro pulldown assay. Such host cell/pUL37 interactions provide further insights into the multifunctional role of this herpesviral tegument protein. Copyright © 2011 Elsevier Inc. All rights reserved.

The UL24 protein of herpes simplex virus 1 affects the sub-cellular distribution of viral glycoproteins involved in fusion

Energy Technology Data Exchange (ETDEWEB)

Ben Abdeljelil, Nawel; Rochette, Pierre-Alexandre; Pearson, Angela, E-mail: angela.pearson@iaf.inrs.ca

2013-09-15

Mutations in UL24 of herpes simplex virus type 1 can lead to a syncytial phenotype. We hypothesized that UL24 affects the sub-cellular distribution of viral glycoproteins involved in fusion. In non-immortalized human foreskin fibroblasts (HFFs) we detected viral glycoproteins B (gB), gD, gH and gL present in extended blotches throughout the cytoplasm with limited nuclear membrane staining; however, in HFFs infected with a UL24-deficient virus (UL24X), staining for the viral glycoproteins appeared as long, thin streaks running across the cell. Interestingly, there was a decrease in co-localized staining of gB and gD with F-actin at late times in UL24X-infected HFFs. Treatment with chemical agents that perturbed the actin cytoskeleton hindered the formation of UL24X-induced syncytia in these cells. These data support a model whereby the UL24 syncytial phenotype results from a mislocalization of viral glycoproteins late in infection. - Highlights: • UL24 affects the sub-cellular distribution of viral glycoproteins required for fusion. • Sub-cellular distribution of viral glycoproteins varies in cell-type dependent manner. • Drugs targeting actin microfilaments affect formation of UL24-related syncytia in HFFs.

POLA PENGASUHAN ISLAMI DALAM PENDIDIKAN KELUARGA (Penguatan Peran Keluarga Jamaah Masjid Baitul Abror Teja Timur

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Saiful Hadi

2017-07-01

Full Text Available Pendidikan Islam memiliki varian yang kompleks, tidak hanya pada kegiatan pendidikan formal, dan non formal, akan tetapi juga ada pada pendidikan informal, ketiganya memiliki keterkaitan yang sinergis untuk saling menguatkan, sebagaimana halnya yang terjadi pada ibu-ibu Jamaah masjid Baitul Abror yang putra-putrinya mengikuti pendidikan pra sekolah pada RA. Muslimat NU yang dikelola oleh Ta’mir masjid. Para Ibu jama’ah yang rata-rata tingkat pendidikan rendah, mereka minim pengetahuan, pengalaman dn keterampilan dalam memberikan pengasuhan secara islami, hal tersebut menjadi concern sasaran program pengabdian akademik dalam memberikan penguatan untuk meningkatkan pengetahuan, keterampilan dan afeksi dalam mengasuh pertumbuhan dan perkembangan anak khususnya usia pra sekolah. Program penguatan  yang dikhususkan pada peningkatan pengetahuan dalam mengasuh, praktek pengasuhan dan keterampilan dalam memberikan perlindungan kepada anak, ternyata memberi kontribusi yang signifikan terhadap perolehan ketiga aspek yang diberikan selama mengikuti kegiatan penguatan tersebut. Hal tersebut terlihat pada saat proses kegiatan pengabdian berlangsung seperti tanggapan dan respon tentang materi dan praktek yang dilakukan bersama antara Tim Pengabdian dan pra ibu jama’ah masjid.

WATER QUALITY EVALUATION OF CRIŞUL ALB AND CRIŞUL NEGRU RIVERS CATCHMENTS, FROM CODRU-MOMA MOUNTAINS (WEST OF ROMANIA, USING BENTHIC INVERTEBRATES COMMUNITIES

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Andreea VARGA

2010-01-01

Full Text Available Water quality evaluation of the two watersheds involved the collection of thirteen samples from the tributaries of Crişul Alb and Crişul Negru rivers. The samples were collected in june 2010 with a benthic net, which had the mesh size of 250 µm, by disturbing the substrate, being thus qualitative samples. To get an overview, a series of physical-chemical parameters (water temperature, pH, oxygen, conductivity, cyanide, nitrates, nitrites, phosphates was studied in parallel with the study of benthic community. In most of the sampling points the major group of benthic macroinvertebrates were found and in some EPT group (Ephemeroptera, Plecoptera, Trichoptera prevailed even, which is known as a clean freshwater group, sensitive to pollution and human impact.

Novel Structure and Unexpected RNA-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein UL21

Energy Technology Data Exchange (ETDEWEB)

Metrick, Claire M.; Heldwein, Ekaterina E. (Tufts-MED)

2016-04-06

Proteins forming the tegument layers of herpesviral virions mediate many essential processes in the viral replication cycle, yet few have been characterized in detail. UL21 is one such multifunctional tegument protein and is conserved among alphaherpesviruses. While UL21 has been implicated in many processes in viral replication, ranging from nuclear egress to virion morphogenesis to cell-cell spread, its precise roles remain unclear. Here we report the 2.7-Å crystal structure of the C-terminal domain of herpes simplex virus 1 (HSV-1) UL21 (UL21C), which has a unique α-helical fold resembling a dragonfly. Analysis of evolutionary conservation patterns and surface electrostatics pinpointed four regions of potential functional importance on the surface of UL21C to be pursued by mutagenesis. In combination with the previously determined structure of the N-terminal domain of UL21, the structure of UL21C provides a 3-dimensional framework for targeted exploration of the multiple roles of UL21 in the replication and pathogenesis of alphaherpesviruses. Additionally, we describe an unanticipated ability of UL21 to bind RNA, which may hint at a yet unexplored function.

IMPORTANCEDue to the limited genomic coding capacity of viruses, viral proteins are often multifunctional, which makes them attractive antiviral targets. Such multifunctionality, however, complicates their study, which often involves constructing and characterizing null mutant viruses. Systematic exploration of these multifunctional proteins requires detailed road maps in the form of 3-dimensional structures. In this work, we determined the crystal structure of the C-terminal domain of UL21, a multifunctional tegument protein that is conserved among alphaherpesviruses. Structural analysis pinpointed surface areas of potential functional importance that provide a starting point for mutagenesis. In addition, the unexpected RNA-binding ability of UL21 may expand its functional repertoire

Herpes Simplex Virus 1 UL24 Abrogates the DNA Sensing Signal Pathway by Inhibiting NF-κB Activation.

Science.gov (United States)

Xu, Haiyan; Su, Chenhe; Pearson, Angela; Mody, Christopher H; Zheng, Chunfu

2017-04-01

Cyclic GMP-AMP synthase (cGAS) is a newly identified DNA sensor that recognizes foreign DNA, including the genome of herpes simplex virus 1 (HSV-1). Upon binding of viral DNA, cGAS produces cyclic GMP-AMP, which interacts with and activates stimulator of interferon genes (STING) to trigger the transcription of antiviral genes such as type I interferons (IFNs), and the production of inflammatory cytokines. HSV-1 UL24 is widely conserved among members of the herpesviruses family and is essential for efficient viral replication. In this study, we found that ectopically expressed UL24 could inhibit cGAS-STING-mediated promoter activation of IFN-β and interleukin-6 (IL-6), and UL24 also inhibited interferon-stimulatory DNA-mediated IFN-β and IL-6 production during HSV-1 infection. Furthermore, UL24 selectively blocked nuclear factor κB (NF-κB) but not IFN-regulatory factor 3 promoter activation. Coimmunoprecipitation analysis demonstrated that UL24 bound to the endogenous NF-κB subunits p65 and p50 in HSV-1-infected cells, and UL24 was also found to bind the Rel homology domains (RHDs) of these subunits. Furthermore, UL24 reduced the tumor necrosis factor alpha (TNF-α)-mediated nuclear translocation of p65 and p50. Finally, mutational analysis revealed that the region spanning amino acids (aa) 74 to 134 of UL24 [UL24(74-134)] is responsible for inhibiting cGAS-STING-mediated NF-κB promoter activity. For the first time, UL24 was shown to play an important role in immune evasion during HSV-1 infection. IMPORTANCE NF-κB is a critical component of the innate immune response and is strongly induced downstream of most pattern recognition receptors (PRRs), leading to the production of IFN-β as well as a number of inflammatory chemokines and interleukins. To establish persistent infection, viruses have evolved various mechanisms to counteract the host NF-κB pathway. In the present study, for the first time, HSV-1 UL24 was demonstrated to inhibit the activation of NF

Involvement of the UL24 protein in herpes simplex virus 1-induced dispersal of B23 and in nuclear egress

International Nuclear Information System (INIS)

Lymberopoulos, Maria H.; Bourget, Amelie; Abdeljelil, Nawel Ben; Pearson, Angela

2011-01-01

UL24 of herpes simplex virus 1 (HSV-1) is widely conserved within the Herpesviridae family. Herein, we tested the hypothesis that UL24, which we have previously shown to induce the redistribution of nucleolin, also affects the localization of the nucleolar protein B23. We found that HSV-1-induced dispersal of B23 was dependent on UL24. The conserved N-terminal portion of UL24 was sufficient to induce the redistribution of B23 in transient transfection assays. Mutational analysis revealed that the endonuclease motif of UL24 was important for B23 dispersal in both transfected and infected cells. Nucleolar protein relocalization during HSV-1 infection was also observed in non-immortalized cells. Analysis of infected cells by electron microscopy revealed a decrease in the ratio of cytoplasmic versus nuclear viral particles in cells infected with a UL24-deficient strain compared to KOS-infected cells. Our results suggest that UL24 promotes nuclear egress of nucleocapsids during HSV-1 infection, possibly though effects on nucleoli.

Localization of HCMV UL33 and US27 in endocytic compartments and viral membranes

DEFF Research Database (Denmark)

Fraile-Ramos, Alberto; Pelchen-Matthews, Annegret; Kledal, Thomas N

2002-01-01

and undergoes constitutive endocytosis and recycling. Here we studied the cellular distributions and trafficking of two other human cytomegalovirus chemokine receptor-like proteins, UL33 and US27, in transfected and human cytomegalovirus-infected cells. Immunofluorescence staining indicated that UL33 and US27......The human cytomegalovirus genome encodes four putative seven transmembrane domain chemokine receptor-like proteins. Although important in viral pathogenesis, little is known about the properties or functions of these proteins. We previously reported that US28 is located in endocytic vesicles......27 undergoes endocytosis. By immunogold labeling of cryosections and electron microscopy, UL33 was seen to localize to multivesicular bodies (MVBs or multivesicular endosomes). Electron microscopy analysis of human cytomegalovirus-infected cells showed that most virus particles wrapped individually...

La Politique coloniale française et les Ahl Shaykh Ma al-cAynin. Jihad et resistances tribales

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Pierre Bonte

2011-07-01

Full Text Available El destino de Ahl Shaykh Mâ al-cAynîn está conectado a la resistencia contra la colonización europea en el Sahara y Marruecos. La literatura colonial francesa ha concebido la lucha del Sheij como consecuencia de un panislamismo activista. El contexto tribal regional lleva al Sheij a oponerse a la colonización francesa en Mauritania y Marruecos cuestionándose la legitimidad dinástica alawi. El desarrollo de la yihad concluyó con el nombramiento del sultán de Marruecos. Se subraya las contradicciones de un proyecto político basado en el guerrero tlamid del Sheij y las movilizaciones tribales contra el orden colonial. The fate of the Ahl Shaykh Mâ al-cAynîn is connected to the resistance against the European colonization in Sahara and Morocco. The french colonial literature has conceived the Shaykh’s fight as a consequence of an activistic panislamism. As a matter of fact it is located in a tribal regional context leading the Shaykh to be opposed to the French colonization in Mauritania and Morocco and to question finally the calawi dynastic legitimacy. The development of the jihad concluded in the name of the Moroccan Sultan underlines the contradictions of a political project depending on the warrior tlamid of the Shaykh and tribal mobilizations against the colonial order. The check of the jihad reduces the family’s part in the organization of the resistance; after 1920 this part becomes a secondary one.

Hubungan Shalat Fardu Berjamaah Dengan Kecerdasan Emosional Pada Jamaah Mesjid Al Jihad Banjarmasin

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Ahmad Jauhari

2017-05-01

Full Text Available Al Jihad  Mosque Banjarmasin is a mosque that is identical with Muhammadiyah, this mosque is followed by many pilgrims and loyal at the time of the implementation of prayers fardu congregation. Jamaah consists of various groups regardless of background, both in terms of age, economy, organization and even the sick pilgrims (post-stroke are actively involved in congregation. Active Jamaat prayers in congregation do not only come from residents around the mosque complex, but also many pilgrims who come from outside the mosque complex, even the distance difference between their residence with the mosque a few kilometers. In heavy rainy weather conditions, they still enthusiastically follow the prayers in congregation fardu mosque. In addition, there are things that are felt by pilgrims such as comfort, tranquility of heart and mind, emotional stability, silaturrahim which all is related to emotional intelligence. In this study, the main problem is how is the relationship of prayer in congregation with emotional intelligence in the congregation of Al Jihad Mosque Banjarmasin ?. The method used is quantitative and qualitative descriptive method with methodological arrangement such as approach and type of research, research location, population and sample, data and data source, procedure and data collection, quantitative and qualitative technical data analysis. The result of the study found that there is a correlation between salat fardu congregation with emotional intelligence, this is proved by the data from questionnaires from 30 pilgrims (respondents that is: able to control the impulse of worldly lusts with the highest opinion is 60% said yes and 40% stated sometimes .Motivating yourself with the highest opinion is 90% states yes and 10% states sometimes. Able to survive in the face of trials with the highest opinion is 86.67 states yes and 13, 33 states sometimes. No exaggeration with the highest opinion is 90% states yes and 10% states

The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain.

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Christina Funk

2015-06-01

Full Text Available Progeny capsids of herpesviruses leave the nucleus by budding through the nuclear envelope. Two viral proteins, the membrane protein pUL34 and the nucleo-phosphoprotein pUL31 form the nuclear egress complex that is required for capsid egress out of the nucleus. All pUL31 orthologs are composed of a diverse N-terminal domain with 1 to 3 basic patches and a conserved C-terminal domain. To decipher the functions of the N-terminal domain, we have generated several Herpes simplex virus mutants and show here that the N-terminal domain of pUL31 is essential with basic patches being critical for viral propagation. pUL31 and pUL34 entered the nucleus independently of each other via separate routes and the N-terminal domain of pUL31 was required to prevent their premature interaction in the cytoplasm. Unexpectedly, a classical bipartite nuclear localization signal embedded in this domain was not required for nuclear import of pUL31. In the nucleus, pUL31 associated with the nuclear envelope and newly formed capsids. Viral mutants lacking the N-terminal domain or with its basic patches neutralized still associated with nucleocapsids but were unable to translocate them to the nuclear envelope. Replacing the authentic basic patches with a novel artificial one resulted in HSV1(17+Lox-UL31-hbpmp1mp2, that was viable but delayed in nuclear egress and compromised in viral production. Thus, while the C-terminal domain of pUL31 is sufficient for the interaction with nucleocapsids, the N-terminal domain was essential for capsid translocation to sites of nuclear egress and a coordinated interaction with pUL34. Our data indicate an orchestrated sequence of events with pUL31 binding to nucleocapsids and escorting them to the inner nuclear envelope. We propose a common mechanism for herpesviral nuclear egress: pUL31 is required for intranuclear translocation of nucleocapsids and subsequent interaction with pUL34 thereby coupling capsid maturation with primary

Labeling and localization of the herpes simplex virus capsid protein UL25 and its interaction with the two triplexes closest to the penton

Science.gov (United States)

Conway, James F.; Cockrell, Shelley K.; Copeland, Anna Maria; Newcomb, William W.; Brown, Jay C.; Homa, Fred L.

2010-01-01

The herpes simplex virus type 1 (HSV-1) UL25 protein is one of seven viral proteins that are required for DNA cleavage and packaging. Together with UL17, UL25 forms part of an elongated molecule referred to as the C-capsid-specific component or CCSC. Five copies of the CCSC are located at each of the capsid vertices on DNA-containing capsids. To study the conformation of UL25 as it is folded on the capsid surface, we identified the sequence recognized by a UL25-specific monoclonal antibody and localized the epitope on the capsid surface by immunogold electron microscopy. The epitope mapped to amino acids 99-111 adjacent to the region of the protein (amino acids 1-50) that is required for capsid binding. In addition, cryo-EM reconstructions of C-capsids in which the green fluorescent protein (GFP) was fused within the N-terminus of UL25 localized the point of contact between UL25 and GFP. The result confirmed the modeled location of the UL25 protein in the CCSC density as the region that is distal to the penton with the N-terminus of UL25 making contact with the triplex one removed from the penton. Immunofluorescence experiments at early times during infection demonstrated that UL25-GFP was present on capsids located within the cytoplasm and adjacent to the nucleus. These results support the view that UL25 is present on incoming capsids with the capsid binding domain of UL25 located on the surface of the mature DNA-containing capsid. PMID:20109467

Bovine herpesvirus type-1 glycoprotein K (gK) interacts with UL20 and is required for infectious virus production

Energy Technology Data Exchange (ETDEWEB)

Haque, Muzammel; Stanfield, Brent; Kousoulas, Konstantin G.

2016-12-15

We have previously shown that the HSV-1 gK and UL20 proteins interact and function in virion envelopment, membrane fusion, and neuronal entry. Alignment of the predicted secondary structures of gKs encoded by BoHV-1, HSV-1, HSV-2, EHV-1 and VZV indicated a high degree of domain conservation. Two BoHV-1 gK-null mutant viruses were created by either gK gene deletion or stop codon insertion. In addition, a V5 epitope-tag was inserted at the carboxyl terminus of gK gene to detect gK. The engineered gK-null mutant viruses failed to replicate and produce viral plaques. Co-immunoprecipitation of gK and UL20 expressed via different methods revealed that gK and UL20 physically interacted in the presence or absence of other viral proteins. Confocal microscopy showed that gK and UL20 colocalized in infected cells. These results indicate that BoHV-1 gK and UL20 may function in a similar manner to other alphaherpesvirus orthologues specified by HSV-1, PRV and EHV-1. -- Highlights: •Glycoprotein K(gK) is conserved among alphaherpesviruses and serves similar functions. •The bovine herpesvirus-1 gK and UL20 proteins physically interact in a similar manner to herpes simplex virus type 1 and equine herpesvirus-1. •The bovine herpesvirus-1 (BoHV-1) gK interacts with UL20 and is essential for virus replication and spread.

Bovine herpesvirus type-1 glycoprotein K (gK) interacts with UL20 and is required for infectious virus production

International Nuclear Information System (INIS)

Haque, Muzammel; Stanfield, Brent; Kousoulas, Konstantin G.

2016-01-01

We have previously shown that the HSV-1 gK and UL20 proteins interact and function in virion envelopment, membrane fusion, and neuronal entry. Alignment of the predicted secondary structures of gKs encoded by BoHV-1, HSV-1, HSV-2, EHV-1 and VZV indicated a high degree of domain conservation. Two BoHV-1 gK-null mutant viruses were created by either gK gene deletion or stop codon insertion. In addition, a V5 epitope-tag was inserted at the carboxyl terminus of gK gene to detect gK. The engineered gK-null mutant viruses failed to replicate and produce viral plaques. Co-immunoprecipitation of gK and UL20 expressed via different methods revealed that gK and UL20 physically interacted in the presence or absence of other viral proteins. Confocal microscopy showed that gK and UL20 colocalized in infected cells. These results indicate that BoHV-1 gK and UL20 may function in a similar manner to other alphaherpesvirus orthologues specified by HSV-1, PRV and EHV-1. -- Highlights: •Glycoprotein K(gK) is conserved among alphaherpesviruses and serves similar functions. •The bovine herpesvirus-1 gK and UL20 proteins physically interact in a similar manner to herpes simplex virus type 1 and equine herpesvirus-1. •The bovine herpesvirus-1 (BoHV-1) gK interacts with UL20 and is essential for virus replication and spread.

A Tyrosine-Based Trafficking Motif of the Tegument Protein pUL71 Is Crucial for Human Cytomegalovirus Secondary Envelopment.

Science.gov (United States)

Dietz, Andrea N; Villinger, Clarissa; Becker, Stefan; Frick, Manfred; von Einem, Jens

2018-01-01

The human cytomegalovirus (HCMV) tegument protein pUL71 is required for efficient secondary envelopment and accumulates at the Golgi compartment-derived viral assembly complex (vAC) during infection. Analysis of various C-terminally truncated pUL71 proteins fused to enhanced green fluorescent protein (eGFP) identified amino acids 23 to 34 as important determinants for its Golgi complex localization. Sequence analysis and mutational verification revealed the presence of an N-terminal tyrosine-based trafficking motif (YXXΦ) in pUL71. This led us to hypothesize a requirement of the YXXΦ motif for the function of pUL71 in infection. Mutation of both the tyrosine residue and the entire YXXΦ motif resulted in an altered distribution of mutant pUL71 at the plasma membrane and in the cytoplasm during infection. Both YXXΦ mutant viruses exhibited similarly decreased focal growth and reduced virus yields in supernatants. Ultrastructurally, mutant-virus-infected cells exhibited impaired secondary envelopment manifested by accumulations of capsids undergoing an envelopment process. Additionally, clusters of capsid accumulations surrounding the vAC were observed, similar to the ultrastructural phenotype of a UL71-deficient mutant. The importance of endocytosis and thus the YXXΦ motif for targeting pUL71 to the Golgi complex was further demonstrated when clathrin-mediated endocytosis was inhibited either by coexpression of the C-terminal part of cellular AP180 (AP180-C) or by treatment with methyl-β-cyclodextrin. Both conditions resulted in a plasma membrane accumulation of pUL71. Altogether, these data reveal the presence of a functional N-terminal endocytosis motif that is an important determinant for intracellular localization of pUL71 and that is furthermore required for the function of pUL71 during secondary envelopment of HCMV capsids at the vAC. IMPORTANCE Human cytomegalovirus (HCMV) is the leading cause of birth defects among congenital virus infections and can

Multiple 5' ends of human cytomegalovirus UL57 transcripts identify a complex, cycloheximide-resistant promoter region that activates oriLyt

International Nuclear Information System (INIS)

Kiehl, Anita; Huang, Lili; Franchi, David; Anders, David G.

2003-01-01

The human cytomegalovirus (HCMV) UL57 gene lies adjacent to HCMV oriLyt, from which it is separated by an organizationally conserved, mostly noncoding region that is thought to both regulate UL57 expression and activate oriLyt function. However, the UL57 promoter has not been studied. We determined the 5' ends of UL57 transcripts toward an understanding of the potential relationship between UL57 expression and oriLyt activation. The results presented here identified three distinct 5' ends spread over 800 bp, at nt 90302, 90530, and 91138; use of these sites exhibited differential sensitivity to phosphonoformic acid treatment. Interestingly, a 10-kb UL57 transcript accumulated in cycloheximide-treated infected cells, even though other early transcripts were not detectable. However, the 10-kb transcript did not accumulate in cells treated with the more stringent translation inhibitor anisomycin. Consistent with the notion that the identified 5' ends arise from distinct transcription start sites, the sequences upstream of sites I and II functioned as promoters responsive to HCMV infection in transient assays. However, the origin-proximal promoter region III required downstream sequences for transcriptional activity. Mutation of candidate core promoter elements suggested that promoter III is regulated by an initiator region (Inr) and a downstream promoter element. Finally, a 42-bp sequence containing the candidate Inr activated a minimal oriLyt core construct in transient replication assays. Thus, these studies showed that a large, complex promoter region with novel features controls UL57 expression, and identified a sequence that regulates both UL57 transcription and oriLyt activation

Human cytomegalovirus UL145 gene is highly conserved among ...

Indian Academy of Sciences (India)

PRAKASH KUMAR

capable of causing infections that persist lifelong, and normally ... 1 Virus Laboratory, Affiliated ShengJing Hospital, China Medical University, Shenyang 110004, P. R. China. 2Department of .... Elmer, USA), and negative controls were included in each round of .... variability of the UL145 gene in field isolates. To answer this.

UL36 Rescues Apoptosis Inhibition and In vivo Replication of a Chimeric MCMV Lacking the M36 Gene

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M. Zeeshan Chaudhry

2017-07-01

Full Text Available Apoptosis is an important defense mechanism mounted by the immune system to control virus replication. Hence, cytomegaloviruses (CMV evolved and acquired numerous anti-apoptotic genes. The product of the human CMV (HCMV UL36 gene, pUL36 (also known as vICA, binds to pro-caspase-8, thus inhibiting death-receptor apoptosis and enabling viral replication in differentiated THP-1 cells. In vivo studies of the function of HCMV genes are severely limited due to the strict host specificity of cytomegaloviruses, but CMV orthologues that co-evolved with other species allow the experimental study of CMV biology in vivo. The mouse CMV (MCMV homolog of the UL36 gene is called M36, and its protein product (pM36 is a functional homolog of vICA that binds to murine caspase-8 and inhibits its activation. M36-deficient MCMV is severely growth impaired in macrophages and in vivo. Here we show that pUL36 binds to the murine pro-caspase-8, and that UL36 expression inhibits death-receptor apoptosis in murine cells and can replace M36 to allow MCMV growth in vitro and in vivo. We generated a chimeric MCMV expressing the UL36 ORF sequence instead of the M36 one. The newly generated MCMVUL36 inhibited apoptosis in macrophage lines RAW 264.7, J774A.1, and IC-21 and its growth was rescued to wild type levels. Similarly, growth was rescued in vivo in the liver and spleen, but only partially in the salivary glands of BALB/c and C57BL/6 mice. In conclusion, we determined that an immune-evasive HCMV gene is conserved enough to functionally replace its MCMV counterpart and thus allow its study in an in vivo setting. As UL36 and M36 proteins engage the same molecular host target, our newly developed model can facilitate studies of anti-viral compounds targeting pUL36 in vivo.

The early UL31 gene of equine herpesvirus 1 encodes a single-stranded DNA-binding protein that has a nuclear localization signal sequence at the C-terminus

Energy Technology Data Exchange (ETDEWEB)

Kim, Seongman; Chul Ahn, Byung; O' Callaghan, Dennis J. [Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932 (United States); Kim, Seong Kee, E-mail: skim1@lsuhsc.edu [Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932 (United States)

2012-10-25

The amino acid sequence of the UL31 protein (UL31P) of equine herpesvirus 1 (EHV-1) has homology to that of the ICP8 of herpes simplex virus type 1 (HSV-1). Here we show that the UL31 gene is synergistically trans-activated by the IEP and the UL5P (EICP27). Detection of the UL31 RNA transcript and the UL31P in EHV-1-infected cells at 6 h post-infection (hpi) as well as metabolic inhibition assays indicated that UL31 is an early gene. The UL31P preferentially bound to single-stranded DNA over double-stranded DNA in gel shift assays. Subcellular localization of the green fluorescent protein (GFP)-UL31 fusion proteins revealed that the C-terminal 32 amino acid residues of the UL31P are responsible for the nuclear localization. These findings may contribute to defining the role of the UL31P single-stranded DNA-binding protein in EHV-1 DNA replication.

The early UL31 gene of equine herpesvirus 1 encodes a single-stranded DNA-binding protein that has a nuclear localization signal sequence at the C-terminus

International Nuclear Information System (INIS)

Kim, Seongman; Chul Ahn, Byung; O’Callaghan, Dennis J.; Kim, Seong Kee

2012-01-01

The amino acid sequence of the UL31 protein (UL31P) of equine herpesvirus 1 (EHV-1) has homology to that of the ICP8 of herpes simplex virus type 1 (HSV-1). Here we show that the UL31 gene is synergistically trans-activated by the IEP and the UL5P (EICP27). Detection of the UL31 RNA transcript and the UL31P in EHV-1-infected cells at 6 h post-infection (hpi) as well as metabolic inhibition assays indicated that UL31 is an early gene. The UL31P preferentially bound to single-stranded DNA over double-stranded DNA in gel shift assays. Subcellular localization of the green fluorescent protein (GFP)–UL31 fusion proteins revealed that the C-terminal 32 amino acid residues of the UL31P are responsible for the nuclear localization. These findings may contribute to defining the role of the UL31P single-stranded DNA-binding protein in EHV-1 DNA replication.

PENDEKATAN HUKUM ISLAM TERHADAP JIHAD DAN TERORISME

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Lukman Arake

2012-06-01

Full Text Available Abstract:   There is a presumption of some circles of non-Muslims that Muslims are the spreader of terrors and terrorism throughout the world through the implementation of the concept of jihād. This assumption seemed to be justified the emerging terrorism cases involving Muslim actors, such as suicide bombings. This paper aims to clarify the issue by critically scrutinizing the true meaning of jihād rooted both in the holy book the al-Qur’an and sunnah of the Prophet Muhammad. Socio-historical approach is applied to better understand the holistic context of the meaning of jihād concept in both sources of Islamic teachings. The author concludes that the presumption is a misconception resulting from ignorance of certain parties about the true meaning of jihād in Islam. There is also a possibility that the misunderstanding is intentional, because the motives of abusing the dignity of Islamic teachings, especially about jihād.  Abstrak:  Pada sebagian kalangan non-muslim terdapat anggapan bahwa orang Islam adalah penyebar teror dan terorisme di seluruh dunia melalui implementasi konsep jihād. Anggapan itu seolah mendapatkan pembenaran dengan munculnya kasus-kasus terorisme yang melibatkan pelaku-pelaku muslim, seperti bom bunuh diri. Tulisan ini bertujuan untuk mengklarifikasi masalah tersebut dengan cara menelisik secara kritis pemaknaan jihād yang sebenarnya baik yang termaktub dalam kitab suci al-Qur’an maupun sunnah Nabi Muhammad saw. Pendekatan sosial-historis diterapkan untuk lebih memahami konteks holistik bagi pemaknaan konsep jihad dalam dua sumber ajaran Islam itu. Penulis berkesimpulan bahwa anggapan tersebut adalah suatu kesalahpahaman akibat dari ketidaktahuan pihak-pihak tertentu tentang makna jihād yang sebenarnya dalam Islam. Tidak tertutup kemungkinan bahwa kesalahpahaman itu disengaja, karena adanya motif-motif untuk mencederai keluhuran ajaran Islam, khususnya tentang jihād.

The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells.

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Ildar Gabaev

2011-12-01

Full Text Available Human cytomegalovirus (CMV exerts diverse and complex effects on the immune system, not all of which have been attributed to viral genes. Acute CMV infection results in transient restrictions in T cell proliferative ability, which can impair the control of the virus and increase the risk of secondary infections in patients with weakened or immature immune systems. In a search for new immunomodulatory proteins, we investigated the UL11 protein, a member of the CMV RL11 family. This protein family is defined by the RL11 domain, which has homology to immunoglobulin domains and adenoviral immunomodulatory proteins. We show that pUL11 is expressed on the cell surface and induces intercellular interactions with leukocytes. This was demonstrated to be due to the interaction of pUL11 with the receptor tyrosine phosphatase CD45, identified by mass spectrometry analysis of pUL11-associated proteins. CD45 expression is sufficient to mediate the interaction with pUL11 and is required for pUL11 binding to T cells, indicating that pUL11 is a specific CD45 ligand. CD45 has a pivotal function regulating T cell signaling thresholds; in its absence, the Src family kinase Lck is inactive and signaling through the T cell receptor (TCR is therefore shut off. In the presence of pUL11, several CD45-mediated functions were inhibited. The induction of tyrosine phosphorylation of multiple signaling proteins upon TCR stimulation was reduced and T cell proliferation was impaired. We therefore conclude that pUL11 has immunosuppressive properties, and that disruption of T cell function via inhibition of CD45 is a previously unknown immunomodulatory strategy of CMV.

AWI Moored ULS Data, Greenland Sea and Fram Strait, 1991-2002

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of Upward Looking Sonar (ULS) data from 11 moorings in the Greenland Sea. Parameters in the processed data files include ice draft, water...

Vaccination with a HSV-2 UL24 mutant induces a protective immune response in murine and guinea pig vaginal infection models.

Science.gov (United States)

Visalli, Robert J; Natuk, Robert J; Kowalski, Jacek; Guo, Min; Blakeney, Susan; Gangolli, Seema; Cooper, David

2014-03-10

The rational design and development of genetically attenuated HSV-2 mutant viruses represent an attractive approach for developing both prophylactic and therapeutic vaccines for genital herpes. Previously, HSV-2 UL24 was shown to be a virulence determinant in both murine and guinea pig vaginal infection models. An UL24-βgluc insertion mutant produced syncytial plaques and replicated to nearly wild type levels in tissue culture, but induced little or no pathological effects in recipient mice or guinea pigs following vaginal infection. Here we report that immunization of mice or guinea pigs with high or low doses of UL24-βgluc elicited a highly protective immune response. UL24-βgluc immunization via the vaginal or intramuscular routes was demonstrated to protect mice from a lethal vaginal challenge with wild type HSV-2. Moreover, antigen re-stimulated splenic lymphocytes harvested from immunized mice exhibited both HSV-2 specific CTL activity and IFN-γ expression. Humoral anti-HSV-2 responses in serum were Th1-polarized (IgG2a>IgG1) and contained high-titer anti-HSV-2 neutralizing activity. Guinea pigs vaccinated subcutaneously with UL24-βgluc or the more virulent parental strain (186) were challenged with a heterologous HSV-2 strain (MS). Acute disease scores were nearly indistinguishable in guinea pigs immunized with either virus. Recurrent disease scores were reduced in UL24-βgluc immunized animals but not to the same extent as those immunized with strain 186. In addition, challenge virus was not detected in 75% of guinea pigs subcutaneously immunized with UL24-βgluc. In conclusion, disruption of the UL24 gene is a prime target for the development of a genetically attenuated live HSV-2 vaccine. Copyright © 2014 Elsevier Ltd. All rights reserved.

Down-regulation of human cytomegalovirus UL138, a novel latency ...

Indian Academy of Sciences (India)

2013-07-12

Jul 12, 2013 ... observed a 74.6% decrease in luciferase activity and a 46.2% decrease in HCMV UL138 protein expression. Our .... Trizol agent (Takara, Dalian, China), according to the man- ... hybrid primer and polyA structure were found in the se- quence. ..... resolution profiling and analysis of viral and host small RNAs.

QUALITATIVE ASPECTS OF CRIŞUL REPEDE RIVER

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VIGH MELINDA

2012-03-01

Full Text Available Qualitative aspects of Crisul Repede River. The evolution of water quality over the Crişul Repede River is atypical because of natural and anthropic factors. The most significant factors are the geological substrate, and the settlements with their agricultural and industrial activity. The study was performed at three gauging stations for the period 1996-2006, taking into account the annual average values. The considered elements were: the discharge values, temperature, suspensions, oxygen regime, nutrients and phosphorus, taking into consideration their temporal and spatial variation. By comparing them with the admitted limits we could enroll them in various quality classes.

Experimental Study of an Offshore Wind Turbine TLP in ULS Conditions

DEFF Research Database (Denmark)

Wehmeyer, Christof; Ferri, Francesco; Skourup, Jesper

2013-01-01

An extensive model test program has been carried out in order to assess the behavior of a tension leg moored substructure as support of a floating offshore wind turbine (FOWT). The floater was inspired by an industrial design. The tests focused on the ultimate limit state (ULS) behavior, therefor...

Pioneering the human development revolution: Analysing the trajectory of Mahbub ul Haq

NARCIS (Netherlands)

D.R. Gasper (Des)

2011-01-01

textabstractMahbub ul Haq's work to coordinate, establish and propagate the human development approach offers an example of effective leadership in promoting more ethical socio-economic development. This article reviews Pioneering the Human Development Revolution-An Intellectual Biography of Mahbub

Search for inclusive b→ulν decays

International Nuclear Information System (INIS)

Roberts, S.E.; Battle, M.O.; Thorndike, E.H.

1993-01-01

The authors have performed an inclusive analysis of the decay B→Xlν, measuring the lepton and neutrino momentum. They open-quotes detectclose quotes neutrinos via the missing 4-momentum in events, taking advantages of the hermeticity of the CLEO-II detector. The Υ(4S) resonance produces B mesons nearly at rest, and this, coupled with measurements of the lepton and neutrino momenta, provides a reasonable measurement of M X . By studying the distribution of M X they attempt a separation of semileptonic B decays into b→clν and b→ulν components, and infer a value of |V ub /V cb |

Responding to Cyber Jihad: Towards an Effective Counter Narrative

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Bibi van Ginkel

2015-03-01

Full Text Available “Who is in control of the narrative?” is the mantra that now echoes in the hallways of the EU’s headquarters in Brussels. Spurred in part by large-scale jihadist propaganda, approximately 20,000 people from 50 countries have joined the fight in Iraq and Syria. So far, authorities in their countries of origin have not been able to address the jihadist radicalisation messages transmitted via the internet and social media. Many new initiatives were recently announced, however, including the establishment of a European counter-narrative centre in Brussels. Research Fellow Dr. Bibi van Ginkel analyses the role of the internet and social media in processes of radicalisation. It offers an outline of the various aspects of the jihadist narrative, in order better to understand what message needs to be countered. The counter-actions against this cyber jihad can take different forms. Parallel to the way in which advertisement campaigns are tailored to sell products to a certain target group, strategic communication should take into account how a number of recurring elements play a role in the counter-messaging. The understanding of who the target group is, what jihadist narrative is used and how that message can be countered, who the credible messenger should be, and what medium can best be used to deliver the message are all relevant questions that can only be answered in a context-specific manner. The Research Paper concludes with several recommendations on how the recently announced new European counter-narrative centre can effectively contribute to the already diverse landscape of counter-narrative initiatives.

AWI Moored ULS Data, Greenland Sea and Fram Strait, 1991-2002, Version 1

Data.gov (United States)

National Aeronautics and Space Administration — This data set consists of Upward Looking Sonar (ULS) data from 11 moorings in the Greenland Sea. Parameters in the processed data files include ice draft, water...

A proteomic perspective of inbuilt viral protein regulation: pUL46 tegument protein is targeted for degradation by ICP0 during herpes simplex virus type 1 infection.

Science.gov (United States)

Lin, Aaron E; Greco, Todd M; Döhner, Katinka; Sodeik, Beate; Cristea, Ileana M

2013-11-01

Much like the host cells they infect, viruses must also regulate their life cycles. Herpes simples virus type 1 (HSV-1), a prominent human pathogen, uses a promoter-rich genome in conjunction with multiple viral trans-activating factors. Following entry into host cells, the virion-associated outer tegument proteins pUL46 and pUL47 act to increase expression of viral immediate-early (α) genes, thereby helping initiate the infection life cycle. Because pUL46 has gone largely unstudied, we employed a hybrid mass spectrometry-based approach to determine how pUL46 exerts its functions during early stages of infection. For a spatio-temporal characterization of pUL46, time-lapse microscopy was performed in live cells to define its dynamic localization from 2 to 24 h postinfection. Next, pUL46-containing protein complexes were immunoaffinity purified during infection of human fibroblasts and analyzed by mass spectrometry to investigate virus-virus and virus-host interactions, as well as post-translational modifications. We demonstrated that pUL46 is heavily phosphorylated in at least 23 sites. One phosphorylation site matched the consensus 14-3-3 phospho-binding motif, consistent with our identification of 14-3-3 proteins and host and viral kinases as specific pUL46 interactions. Moreover, we determined that pUL46 specifically interacts with the viral E3 ubiquitin ligase ICP0. We demonstrated that pUL46 is partially degraded in a proteasome-mediated manner during infection, and that the catalytic activity of ICP0 is responsible for this degradation. This is the first evidence of a viral protein being targeted for degradation by another viral protein during HSV-1 infection. Together, these data indicate that pUL46 levels are tightly controlled and important for the temporal regulation of viral gene expression throughout the virus life cycle. The concept of a structural virion protein, pUL46, performing nonstructural roles is likely to reflect a theme common to many viruses

A Monte Carlo study comparing PIV, ULS and DWLS in the estimation of dichotomous confirmatory factor analysis.

Science.gov (United States)

Nestler, Steffen

2013-02-01

We conducted a Monte Carlo study to investigate the performance of the polychoric instrumental variable estimator (PIV) in comparison to unweighted least squares (ULS) and diagonally weighted least squares (DWLS) in the estimation of a confirmatory factor analysis model with dichotomous indicators. The simulation involved 144 conditions (1,000 replications per condition) that were defined by a combination of (a) two types of latent factor models, (b) four sample sizes (100, 250, 500, 1,000), (c) three factor loadings (low, moderate, strong), (d) three levels of non-normality (normal, moderately, and extremely non-normal), and (e) whether the factor model was correctly specified or misspecified. The results showed that when the model was correctly specified, PIV produced estimates that were as accurate as ULS and DWLS. Furthermore, the simulation showed that PIV was more robust to structural misspecifications than ULS and DWLS. © 2012 The British Psychological Society.

KONSELING ISLAMI MELALUI PENDIDIKAN KESEHATAN SEKSUAL DALAM ISLAM PADA REMAJA

Directory of Open Access Journals (Sweden)

Sugianto Sugianto

2014-01-01

Full Text Available Tulisan ini memberikan informasi yang tepat tentang kondisi kebutuhan remaja yang sesuai dengan tugas perkembangannya yaitu: mengenal fungsi perbedaan jenis kelamin, organ reproduksi dan persiapan pernikahan agar dapat mengenali fungsi anatomi tubuh sesuai dengan nilai-nilai Islam, misalnya tentang kesehatan seksual dalam Islam. Meskipun data yang ditemukan terdapat beragam problematika remaja tentang seksual,  sehingga dibutuhkan profesi konseling  Islami untuk membantu remaja tumbuh kembang secara optimal dalam berprestasi dibidang kognitif-afektif-psikomotorik.  Kemampuan kognitif dengan diupayakannya  pengayaan pengetahuan tentang alam semesta beserta fenomena alam, kemampuan  afektif dengan trampilnya mengolah dan mengendalikan emosi ke arah positif  kepada sesama makhluk hidup,  sedangkan kemampuan psikomotorik dengan adaptifnya manusia dalam bersikap ketika berinteraksi di lingkungan dengan keragaman budaya Bhineka Tunggal Ika. Dengan berdasar pada nilai-nilai pendidikan Islam maka manusia dapat mengoptimalkan 3 daya dengan berdasarkan pada al-Qur’an yang memberikan keselamatan  dan kebahagiaan  pada remaja untuk memahami kesehatan seksual dalam Islam. Kata Kunci: Konseling Islam, Pendidikan  Seksual, Pemuda THROUGH THE ISLAMIC COUNSELLING SEXUAL HEALTH EDUCATION IN ISLAM IN ADOLESCENT. This paper provides precise information  about the conditions in accordance with the needs of adolescent development tasks are: to know the function of gender, reproductive organs and wedding preparations in order to identify the function of anatomy of the body in accordance with Islamic values, example about sexual health in Islam. Although the data were found to contain a variety of sexual problems of adolescence, so it needs the counseling profession Islamic to help teens grow and develop optimally in achievement in the field of cognitive-affective-psychomotor. Cognitive abilities with the enrichment begun all the knowledge of the universe

Analysis of contributions of herpes simplex virus type 1 UL43 protein ...

African Journals Online (AJOL)

Purpose: To investigate whether UL43 protein, which is highly conserved in alpha- and gamma herpes viruses, and a non-glycosylated transmembrane protein, is involved in virus entry and virus-induced cell fusion. Methods: Mutagenesis was accomplished by a markerless two-step Red recombination mutagenesis system ...

Cellular homeoproteins, SATB1 and CDP, bind to the unique region between the human cytomegalovirus UL127 and major immediate-early genes

International Nuclear Information System (INIS)

Lee Jialing; Klase, Zachary; Gao Xiaoqi; Caldwell, Jeremy S.; Stinski, Mark F.; Kashanchi, Fatah; Chao, S.-H.

2007-01-01

An AT-rich region of the human cytomegalovirus (CMV) genome between the UL127 open reading frame and the major immediate-early (MIE) enhancer is referred to as the unique region (UR). It has been shown that the UR represses activation of transcription from the UL127 promoter and functions as a boundary between the divergent UL127 and MIE genes during human CMV infection [Angulo, A., Kerry, D., Huang, H., Borst, E.M., Razinsky, A., Wu, J., Hobom, U., Messerle, M., Ghazal, P., 2000. Identification of a boundary domain adjacent to the potent human cytomegalovirus enhancer that represses transcription of the divergent UL127 promoter. J. Virol. 74 (6), 2826-2839; Lundquist, C.A., Meier, J.L., Stinski, M.F., 1999. A strong negative transcriptional regulatory region between the human cytomegalovirus UL127 gene and the major immediate-early enhancer. J. Virol. 73 (11), 9039-9052]. A putative forkhead box-like (FOX-like) site, AAATCAATATT, was identified in the UR and found to play a key role in repression of the UL127 promoter in recombinant virus-infected cells [Lashmit, P.E., Lundquist, C.A., Meier, J.L., Stinski, M.F., 2004. Cellular repressor inhibits human cytomegalovirus transcription from the UL127 promoter. J. Virol. 78 (10), 5113-5123]. However, the cellular factors which associate with the UR and FOX-like region remain to be determined. We reported previously that pancreatic-duodenal homeobox factor-1 (PDX1) bound to a 45-bp element located within the UR [Chao, S.H., Harada, J.N., Hyndman, F., Gao, X., Nelson, C.G., Chanda, S.K., Caldwell, J.S., 2004. PDX1, a Cellular Homeoprotein, Binds to and Regulates the Activity of Human Cytomegalovirus Immediate Early Promoter. J. Biol. Chem. 279 (16), 16111-16120]. Here we demonstrate that two additional cellular homeoproteins, special AT-rich sequence binding protein 1 (SATB1) and CCAAT displacement protein (CDP), bind to the human CMV UR in vitro and in vivo. Furthermore, CDP is identified as a FOX-like binding protein

Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97.

Science.gov (United States)

Milbradt, Jens; Sonntag, Eric; Wagner, Sabrina; Strojan, Hanife; Wangen, Christina; Lenac Rovis, Tihana; Lisnic, Berislav; Jonjic, Stipan; Sticht, Heinrich; Britt, William J; Schlötzer-Schrehardt, Ursula; Marschall, Manfred

2018-01-13

The nuclear phase of herpesvirus replication is regulated through the formation of regulatory multi-component protein complexes. Viral genomic replication is followed by nuclear capsid assembly, DNA encapsidation and nuclear egress. The latter has been studied intensely pointing to the formation of a viral core nuclear egress complex (NEC) that recruits a multimeric assembly of viral and cellular factors for the reorganization of the nuclear envelope. To date, the mechanism of the association of human cytomegalovirus (HCMV) capsids with the NEC, which in turn initiates the specific steps of nuclear capsid budding, remains undefined. Here, we provide electron microscopy-based data demonstrating the association of both nuclear capsids and NEC proteins at nuclear lamina budding sites. Specifically, immunogold labelling of the core NEC constituent pUL53 and NEC-associated viral kinase pUL97 suggested an intranuclear NEC-capsid interaction. Staining patterns with phospho-specific lamin A/C antibodies are compatible with earlier postulates of targeted capsid egress at lamina-depleted areas. Important data were provided by co-immunoprecipitation and in vitro kinase analyses using lysates from HCMV-infected cells, nuclear fractions, or infectious virions. Data strongly suggest that nuclear capsids interact with pUL53 and pUL97. Combined, the findings support a refined concept of HCMV nuclear trafficking and NEC-capsid interaction.

Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97

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Jens Milbradt

2018-01-01

Full Text Available The nuclear phase of herpesvirus replication is regulated through the formation of regulatory multi-component protein complexes. Viral genomic replication is followed by nuclear capsid assembly, DNA encapsidation and nuclear egress. The latter has been studied intensely pointing to the formation of a viral core nuclear egress complex (NEC that recruits a multimeric assembly of viral and cellular factors for the reorganization of the nuclear envelope. To date, the mechanism of the association of human cytomegalovirus (HCMV capsids with the NEC, which in turn initiates the specific steps of nuclear capsid budding, remains undefined. Here, we provide electron microscopy-based data demonstrating the association of both nuclear capsids and NEC proteins at nuclear lamina budding sites. Specifically, immunogold labelling of the core NEC constituent pUL53 and NEC-associated viral kinase pUL97 suggested an intranuclear NEC-capsid interaction. Staining patterns with phospho-specific lamin A/C antibodies are compatible with earlier postulates of targeted capsid egress at lamina-depleted areas. Important data were provided by co-immunoprecipitation and in vitro kinase analyses using lysates from HCMV-infected cells, nuclear fractions, or infectious virions. Data strongly suggest that nuclear capsids interact with pUL53 and pUL97. Combined, the findings support a refined concept of HCMV nuclear trafficking and NEC-capsid interaction.

Antibodies against human cytomegalovirus late protein UL94 in the pathogenesis of scleroderma-like skin lesions in chronic graft-versus-host disease.

Science.gov (United States)

Pastano, Rocco; Dell'Agnola, Chiara; Bason, Caterina; Gigli, Federica; Rabascio, Cristina; Puccetti, Antonio; Tinazzi, Elisa; Cetto, Gianluigi; Peccatori, Fedro; Martinelli, Giovanni; Lunardi, Claudio

2012-09-01

Human cytomegalovirus (hCMV) infection and its reactivation correlate both with the increased risk and with the worsening of graft-versus-host disease (GVHD). Because scleroderma-like skin lesions can occur in chronic GVHD (cGVHD) in allogeneic stem-cell transplant (HCT) patients and hCMV is relevant in the pathogenesis of systemic sclerosis (SSc), we evaluated the possible pathogenetic link between hCMV and skin cGVHD. Plasma from 18 HCT patients was tested for anti-UL94 and/or anti-NAG-2 antibodies, identified in SSc patients, by direct ELISA assays. Both donors and recipients were anti-hCMV IgG positive, without autoimmune diseases. Patients' purified anti-UL94 and anti-NAG-2 IgG binding to human umbilical endothelial cells (HUVECs) and fibroblasts was performed by FACS analysis and ELISA test. HUVECs apoptosis and fibroblasts proliferation induced by patients' anti-NAG-2 antibodies were measured by DNA fragmentation and cell viability, respectively. About 11/18 patients developed cGVHD and all of them showed skin involvement, ranging from diffuse SSc-like lesions to limited erythema. Eight of eleven cGVHD patients were positive for anti-UL94 and/or anti-NAG-2 antibodies. Remarkably, 4/5 patients who developed diffuse or limited SSc-like lesions had antibodies directed against both UL94 and NAG-2; their anti-NAG-2 IgG-bound HUVECs and fibroblasts induce both endothelial cell apoptosis and fibroblasts proliferation, similar to that induced by purified anti-UL94 and anti-NAG-2 antibodies obtained from SSc patients. In conclusion, our data suggest a pathogenetic link between hCMV infection and scleroderma-like skin cGVHD in HCT patients through a mechanism of molecular mimicry between UL94 viral protein and NAG-2 molecule, as observed in patients with SSc.

Transcription pattern of UL131A-128 mRNA in clinical strains of ...

Indian Academy of Sciences (India)

Human cytomegalovirus (HCMV) mRNA was obtained from human embryonic lung fibroblast cells infected by HCMV clinical strains from urine samples of infants at different kinetic periods. The cDNA of UL131A-128 mRNAs was amplified using reverse transcription-polymerase chain reaction (RT-PCR) and analysed by ...

Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion

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Paolo Romania

2017-07-01

Full Text Available Herein, we demonstrate that HCMV miR-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs. In addition, we show that the rs17481334 G variant, naturally occurring in the ERAP1 3′ UTR, preserves ERAP1 from miR-UL112-5p-mediated degradation. Specifically, HCMV miR-UL112-5p binds the 3′ UTR of ERAP1 A variant, but not the 3′ UTR of ERAP1 G variant, and, accordingly, ERAP1 expression is reduced both at RNA and protein levels only in human fibroblasts homozygous for the A variant. Consistently, HCMV-infected GG fibroblasts were more efficient in trimming viral antigens and being lysed by HCMV-peptide-specific CTLs. Notably, a significantly decreased HCMV seropositivity was detected among GG individuals suffering from multiple sclerosis, a disease model in which HCMV is negatively associated with adult-onset disorder. Overall, our results identify a resistance mechanism to HCMV miR-UL112-5p-based immune evasion strategy with potential implications for individual susceptibility to infection and other diseases.

Taassündinud selleks, et tappa / Olivier Roy ; tõlk. Külli-Riin Tigasson

Index Scriptorium Estoniae

Roy, Olivier

2005-01-01

Islami radikaliseerumisest, fundamentalismist. Autori väitel annavad kristlik ja islamiäärmuslus tunnistust üleilmastumise ajastu kultuurikriisist, islamiäärmusluse kasvulava on eeskätt noorte Euroopa muslimite teine põlvkond

[Prevalence of upper limb work-related musculoskeletal disorders (UL-WMSDs) in workers of the upholstered furniture industry].

Science.gov (United States)

Nicoletti, S; Carino, M; Di Leone, G; Trani, G; Carella, F; Rubino, G; Leone, E; Popolizio, R; Colafiglio, S; Ambrosi, L

2008-01-01

The upholstered furniture industry, the so-called "triangle of the sofa industry", is a geographic area of national and strategic economic importance in southern Italy. The single tasks are carried out mostly manually, with the characteristics of a handicraft approach. The aim of the survey was to assess the prevalence of upper limb work-related musculoskeletal disorders (UL-WMSDs) in 30 factories of the sofa industry located in a large geographic area of the Puglia and Basilicata Regions. In the period 1 January-31 December 2003 a network of occupational physicians investigated a population of 5.477 subjects (exposed n=3481, controls n=1996, M=3865, F=1612) in 30 different factories of the area. More than 60 percent of the total workforce studied was employed in large-sized companies (>500 employees). The following work tasks were considered: filling preparation workers, leather-cutting operators, sewing and upholstery-assembly workers. Case-definition was assessed through standardized procedures: symptoms by questionnaire plus physical and laboratory/imaging findings. Cumulative prevalence rates of UL-WMSDs as at 31 December 2003 reached values of up to 30% in high risk groups. Prevalence rates showed good correlation with the concise OCRA index used for assessment of exposure to repetitive strain and movements of the upper limb. The most frequently occurring disorders were tendon-related cysts and wrist tendonitis. Shoulder disorders were more frequent in male and female leather-cutting operators. This survey showed a significantly high prevalence of UL-WMSDs in sofa industry workers. It did not seem to be confirmed in this study that there was a greater female susceptibility to UL-WMSDs with the exception of carpal tunnel syndrome: gender difference seems to be less relevant at increasing levels of occupational exposure to repetitive movements and exertion of the upper limbs.

Health Information in Modern Standard Arabic (al-ʻArabīyat ul-fuṣḥá)

Science.gov (United States)

... Your Recovery After Cesarean Birth (Part 1) - English MP3 Your Recovery After Cesarean Birth (Part 1) - al-ʻArabīyat ul-fuṣḥá (Modern Standard Arabic) MP3 Your Recovery After Cesarean Birth (Part 1) - English ...

Analysis of irradiated materials in Ul-chin unit 5

International Nuclear Information System (INIS)

Jung, Y. H.; Yoo, B. O.; Kim, H. M.; Joo, Y. S.

2007-02-01

The microstructure examination, the fracture surface observation, the composition analysis and the micro-hardness measurement were carried out for investigation of debris apart from structure in Ul-chin uint 5. As the results of investigation, those of debris were found out screw bolts and the washer. The screw bolts and the washer were coincident with materials from ASTM A-193 by quantitative analysis. The screw bolts and the washer were made by STS 304. Finally, all of screw bolts were parts of the LPSI pump case even though one of them was found in different place. The washer was part of the heat exchanger

Resource Allocation and Cluster Formation for Imperfect NOMA in DL/UL Decoupled HetNets

KAUST Repository

Celik, Abdulkadir; Radaydeh, Redha; Al-Qahtani, Fawaz; Abd El-Malek, Ahmed H.; Alouini, Mohamed-Slim

2017-01-01

Being capable of serving multiple users with the same radio resource, non-orthogonal multiple access (NOMA) can provide desirable performance enhancements in a fair and spectral efficient manner. In this paper, we investigate the resource allocation (RA) and cluster formation (CF) aspects of NOMA for downlink (DL) uplink (UL) decoupled (DUDe) heterogeneous networks (HetNets). A non-ideal NOMA scheme is considered with power disparity and sensitivity constraints (PDSCs), delay tolerance, and residual interference after cancellation. Taking the PDSCs into account, we analytically show that using the DL decoding order limits UL-NOMA performance by that of OMA, while employing an inverse order result in a performance gain that is mainly determined by the channel gain disparity of users. Thereafter, a generic CF method is proposed for any type of user graph, which iteratively forms clusters using Blossom algorithm. Finally, highly non-convex RA problem is converted into a convex form by employing geometric programming (GP) where power and bandwidth are optimized to maximize network sumrate and max-min fairness objectives.

Resource Allocation and Cluster Formation for Imperfect NOMA in DL/UL Decoupled HetNets

KAUST Repository

Celik, Abdulkadir

2017-04-15

Being capable of serving multiple users with the same radio resource, non-orthogonal multiple access (NOMA) can provide desirable performance enhancements in a fair and spectral efficient manner. In this paper, we investigate the resource allocation (RA) and cluster formation (CF) aspects of NOMA for downlink (DL) uplink (UL) decoupled (DUDe) heterogeneous networks (HetNets). A non-ideal NOMA scheme is considered with power disparity and sensitivity constraints (PDSCs), delay tolerance, and residual interference after cancellation. Taking the PDSCs into account, we analytically show that using the DL decoding order limits UL-NOMA performance by that of OMA, while employing an inverse order result in a performance gain that is mainly determined by the channel gain disparity of users. Thereafter, a generic CF method is proposed for any type of user graph, which iteratively forms clusters using Blossom algorithm. Finally, highly non-convex RA problem is converted into a convex form by employing geometric programming (GP) where power and bandwidth are optimized to maximize network sumrate and max-min fairness objectives.

Down-regulation of MHC class I by the Marek's disease virus (MDV) UL49.5 gene product mildly affects virulence in a haplotype-specific fashion.

Science.gov (United States)

Jarosinski, Keith W; Hunt, Henry D; Osterrieder, Nikolaus

2010-09-30

Marek's disease is a devastating neoplastic disease of chickens caused by Marek's disease virus (MDV). MDV down-regulates surface expression of MHC class I molecules, although the mechanism has remained elusive. MDV harbors a UL49.5 homolog that has been shown to down-regulate MHC class I expression in other Varicelloviruses. Using in vitro assays, we showed that MDV pUL49.5 down-regulates MHC class I directly and identified its cytoplasmic tail as essential for this function. In vivo, viruses lacking the cytoplasmic tail of pUL49.5 showed no differences in MD pathogenesis compared to revertant viruses in highly susceptible chickens of the B(19)B(19) MHC class I haplotype, while there was a mild reduction in pathogenic potential of the deletion viruses in chickens more resistant to MD pathogenesis (MHC:B(21)B(21)). We concluded that the pathogenic effect of MHC class I down-regulation mediated by pUL49.5 is small because virus immune evasion possibly requires more than one viral protein. Copyright 2010 Elsevier Inc. All rights reserved.

Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir

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Chou Sunwen

2009-01-01

Full Text Available Abstract The UL97 kinase has been shown to phosphorylate and inactivate the retinoblastoma protein (Rb and has three consensus Rb-binding motifs that might contribute to this activity. Recombinant viruses containing mutations in the Rb-binding motifs generally replicated well in human foreskin fibroblasts with only a slight delay in replication kinetics. Their susceptibility to the specific UL97 kinase inhibitor, maribavir, was also examined. Mutation of the amino terminal motif, which is involved in the inactivation of Rb, also renders the virus hypersensitive to the drug and suggests that the motif may play a role in its mechanism of action.

A comparative study of Ayatollah Motahhari’s views on Jihad and Rawls’ views on Humanitarian Wars

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Amir Maghami

2012-04-01

Full Text Available Since there appears to be a relationship between Ayatollah Mutahhari’s ‘Jihad’ theory and John Rawls’s Humanitarian War theory, and between their shared social concerns, this study aims at investigating whether the two theories are similar or different in terms of legitimacy of war and the use of force. It seems that humanitarian jihad and liberal humanitarian intervention have a similar genesis, the difference being that the former is prescribed on theological foundations and the latter is founded on ethical liberalism, though the two have similar claims. Can this apparently unprofessed resemblance in permissibility of jihad in Jihad theory of Ayatollah Motahhari – as a Muslim jurist and philosopher - and the justification of war to confront violation of human rights in “The Law of Peoples” as a complement to theory of justice of Rawls – as a Kantian liberal philosopher be considered a significant relationship? نسبتی ناخواسته میان نظریه جهاد شهید مرتضی مطهری و جان رالز و مشابهت برخی دغدغه‌های اجتماعی آن‌ها بهانه‌ای است برای کنجکاوی در امکان تشابه یا افتراق نظریه این دو در باب مشروعیت جنگ و توسل ابتدایی به زور. در این بررسی به نظر می‌رسد جهاد بشردوستانه آن گونه که از نامش پیداست سنخیتی با مداخله بشردوستانه دارد؛ با این تفاوت که اولی از منظری ایدئولوژیک و الهی تجویز می‌شود و دومی از منظر لیبرالیسم اخلاقی؛ گر چه هر دو تقریباً مدعای یکسانی دارند. آیا این تشابه علی الظاهر ناخودآگاه در میان موارد تجویز جهاد در نظریه جهاد شهید مطهری به عنوان یک فقیه فلسفه‌گرای مسلمان و توجیه �

SEASONAL AVERAGE FLOW IN RÂUL NEGRU HYDROGRAPHIC BASIN

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VIGH MELINDA

2015-03-01

Full Text Available The Râul Negru hydrographic basin is a well individualised physical-geographical unit inside the Braşov Depression. The flow is controlled by six hydrometric stations placed on the main river and on two important tributaries. The data base for seasonal flow analysis contains the discharges from 1950-2012. The results of data analysis show that there significant space-time differences between multiannual seasonal averages. Some interesting conclusions can be obtained by comparing abundant and scarce periods. Flow analysis was made using seasonal charts Q = f(T. The similarities come from the basin’s relative homogeneity, and the differences from flow’s evolution and trend. Flow variation is analysed using variation coefficient. In some cases appear significant Cv values differences. Also, Cv values trends are analysed according to basins’ average altitude.

The Cytomegalovirus UL146 Gene Product vCXCL1 Targets Both CXCR1 and CXCR2 as an Agonist

DEFF Research Database (Denmark)

Luttichau, H.R.

2010-01-01

Large DNA viruses, such as herpesvirus and poxvirus, encode proteins that target and exploit the chemokine system of their host. UL146 and UL147 in the cytomegalovirus (CMV) genome encode the two CXC chemokines vCXCL1 and vCXCL2. In this study, vCXCL1 was probed against a panel of the 18 classified...... human chemokine receptors. In calcium mobilization assays vCXCL1 acted as an agonist on both CXCR1 and CXCR2 but did not activate or block any of the other 16 chemokine receptors. vCXCL1 was characterized and compared with CXCL1/GRO alpha, CXCL2/GRO beta, CXCL3/GRO gamma, CXCL5/ENA-78, CXCL6/GCP2, CXCL7...

75 FR 54381 - Charles M. Russell National Wildlife Refuge and UL Bend National Wildlife Refuge, MT

Science.gov (United States)

2010-09-07

... DEPARTMENT OF THE INTERIOR Fish and Wildlife Service [FWS-R6-R-2010-N078; 60138-1261-6CCP-S3] Charles M. Russell National Wildlife Refuge and UL Bend National Wildlife Refuge, MT AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of availability: Draft comprehensive conservation plan and draft...

The Potential of Flexible UL/DL Slot Assignment in 5G Systems

DEFF Research Database (Denmark)

Catania, Davide; Gatnau, Marta; Cattoni, Andrea Fabio

2014-01-01

5th Generation (5G) small cells are expected to satisfy the increasing demand for wireless data traffic. In the presence of large scale dense and randomly deployed cells, autonomous and distributed configuration mechanisms are highly desirable. However, small cells typically serve a small number...... of users, such that sudden traffic imbalances between downlink (DL) and uplink (UL) are expected in the new 5G system. We exploit the flexibility of time-division duplex (TDD) to deal with such imbalances by adapting swiftly to instantaneously varying traffic needs. In this paper we propose a distributed...

75 FR 67095 - Charles M. Russell National Wildlife Refuge and UL Bend National Wildlife Refuge, Montana

Science.gov (United States)

2010-11-01

... DEPARTMENT OF THE INTERIOR Fish and Wildlife Service [FWS-R6-R-2010-N215; 60138-1261-6CCP-S3] Charles M. Russell National Wildlife Refuge and UL Bend National Wildlife Refuge, Montana AGENCY: Fish and Wildlife Service, Interior (DOI). ACTION: Notice; extension of comment period. SUMMARY: We, the U.S. Fish...

Krymskokaraimska wersja Melukhat Sha’ul. Wydanie krytyczne i analiza językoznawcza

OpenAIRE

Smętek, Dorota

2012-01-01

Wydział Neofilologii: Katedra Studiów Azjatyckich Rozprawa doktorska udostępnia w wydaniu krytycznym dramat p.t. Melukhat Sha’ul znajdujący się w krymskokaraimskim rękopisie zwanym medżumą i jest pierwszym opracowaniem naukowym tego dzieła. Oryginał rękopisu, o numerze VI-3/22, znajduje się na Krymie. Został on spisany przez Samuela Kohena w drugiej połowie dziewiętnastego wieku, to znaczy w roku 1876 z krótkimi fragmentami zapisanymi w 1875 i 1879. Rękopis zawiera turkijskie tłumaczenie d...

MONTHLY AVERAGE FLOW IN RÂUL NEGRU HYDROGRAPHIC BASIN

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VIGH MELINDA

2014-03-01

Full Text Available Râul Negru hydrographic basin represents a well individualised and relatively homogenous physical-geographical unity from Braşov Depression. The flow is controlled by six hydrometric stations placed on the main collector and on two of the most powerful tributaries. Our analysis period is represented by the last 25 years (1988 - 2012 and it’s acceptable for make pertinent conclusions. The maximum discharge month is April, that it’s placed in the high flow period: March – June. Minimum discharges appear in November - because of the lack of pluvial precipitations; in January because of high solid precipitations and because of water volume retention in ice. Extreme discharge frequencies vary according to their position: in the mountain area – small basin surface; into a depression – high basin surface. Variation coefficients point out very similar variation principles, showing a relative homogeneity of flow processes.

Kas Euroopa suudab panna vastu islamiseerumisele? / Daniel Pipes

Index Scriptorium Estoniae

Pipes, Daniel

2008-01-01

Islami levikust Lääne-Euroopas ja põliseurooplaste vastuseisust islamiseerumisele. Moslem Magdi Allami katoliiklusse vastuvõtmisest ja Geert Wildersi filmist "Fitna", mis näitab islami "sisemist kurjust"

Production and Its Anti-hyperglycemic Effects of γ-Aminobutyric Acid from the Wild Yeast Strain Pichia silvicola UL6-1 and Sporobolomyces carnicolor 402-JB-1.

Science.gov (United States)

Han, Sang-Min; Lee, Jong-Soo

2017-09-01

This study was done to produce γ-aminobutyric acid (GABA) from wild yeast as well as investigate its anti-hyperglycemic effects. Among ten GABA-producing yeast strains, Pichia silvicola UL6-1 and Sporobolomyces carnicolor 402-JB-1 produced high GABA concentration of 134.4 µg/mL and 179.2 µg/mL, respectively. P. silvicola UL6-1 showed a maximum GABA yield of 136.5 µg/mL and 200.8 µg/mL from S. carnicolor 402-JB-1 when they were cultured for 30 hr at 30℃ in yeast extract-peptone-dextrose medium. The cell-free extract from P. silvicola UL6-1 and S. carnicolor 402-JB-1 showed very high anti-hyperglycemic α-glucosidase inhibitory activity of 72.3% and 69.9%, respectively. Additionally, their cell-free extract-containing GABA showed the anti-hyperglycemic effect in streptozotocin-induced diabetic Sprague-Dawley rats.

La expedición a Veracruz y la defensa de San Juan de Ulúa (1819-1825

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Manuel Escalona Jiménez

2000-01-01

Full Text Available En 1819 una expedición militar al mando del teniente general Manuel Cagigal partió de Cádiz hacia La Habana. En 1821 el cuerpo expedicionario, compuesto de unos 200 hombres, ocupó Veracruz, pero pronto se vio obligado a replegarse a la isla de San Juan de Ulúa, donde consiguió resistir hasta 1825, a pesar de estar sometido al severo bloqueo de las fuerzas independentistas mexicanas y combatir en las condiciones más precarias, de tal modo que este episodio militar se ganó la admiración general.In 1819, a military expedition, under the command of Lieutenant General Manuel Cagigal, sailed from Cádiz bound to La Habana. In 1821, the army corps, around 200 soldiers, got hold of Veracruz, but was soon obliged to retire to the island of San Juan de Ulúa, where they managed to resist untill 1825, in spite of the blockade by the Mexican independentist Mexican force and the arduous circumstances of the fight to the extent of getting a general admiration.

RELIGIOUSITY COMMITMENT DALAM MEMODERASI HUBUNGAN BRAND AWARENESS TERHADAP NIAT PEMBELIAN

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Mohammad Fakhruddin Mudzakkir

2014-09-01

Full Text Available Penelitian ini bertujuan untuk mengetahui 1. Pengaruh brand awareness terhadap niat pembelian pada toko roti merk Islami, 2. Pengaruh religousity commitment terhadap niat pembelian pada toko roti merk Islami, 3. Peranan religousity commitment sebagai variabel moderator yang dapat memperkuat pengaruh brand awareness terhadap niat pembelian pada toko roti merk Islami. Jenis penelitian adalah survey. Populasinya adalah konsumen yang melakukan  pembelian pada 3 toko roti Merk Islami di Kota/Kabupaten Malang, yaitu Toko Roti Amanah, Toko Roti As Sunnah, dan Toko Roti Madinah. Teknik pengambilan sampelnya adalah accidental sampling. Penelitian ini menggunakan metode analisis Moderated Regression Analysis. Hasil analisis menunjukkan variabel brand awareness  dan religousity commitment berpengaruh positif dan signifikan terhadap niat pembelian. Religousity commitment tidak dapat berperan sebagai variabel moderasi terhadap hubungan brand awareness terhadap niat pembelian merk produk Islam

Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced Reactivation.

Science.gov (United States)

Mostafa, Heba H; Thompson, Thornton W; Konen, Adam J; Haenchen, Steve D; Hilliard, Joshua G; Macdonald, Stuart J; Morrison, Lynda A; Davido, David J

2018-04-01

In the process of generating herpes simplex virus 1 (HSV-1) mutations in the viral regulatory gene encoding infected cell protein 0 (ICP0), we isolated a viral mutant, termed KOS-NA, that was severely impaired for acute replication in the eyes and trigeminal ganglia (TG) of mice, defective in establishing a latent infection, and reactivated poorly from explanted TG. To identify the secondary mutation(s) responsible for the impaired phenotypes of this mutant, we sequenced the KOS-NA genome and noted that it contained two nonsynonymous mutations in UL39 , which encodes the large subunit of ribonucleotide reductase, ICP6. These mutations resulted in lysine-to-proline (residue 393) and arginine-to-histidine (residue 950) substitutions in ICP6. To determine whether alteration of these amino acids was responsible for the KOS-NA phenotypes in vivo , we recombined the wild-type UL39 gene into the KOS-NA genome and rescued its acute replication phenotypes in mice. To further establish the role of UL39 in KOS-NA's decreased pathogenicity, the UL39 mutations were recombined into HSV-1 (generating UL39 mut ), and this mutant virus showed reduced ocular and TG replication in mice comparable to that of KOS-NA. Interestingly, ICP6 protein levels were reduced in KOS-NA-infected cells relative to the wild-type protein. Moreover, we observed that KOS-NA does not counteract caspase 8-induced apoptosis, unlike wild-type strain KOS. Based on alignment studies with other HSV-1 ICP6 homologs, our data suggest that amino acid 950 of ICP6 likely plays an important role in ICP6 accumulation and inhibition of apoptosis, consequently impairing HSV-1 pathogenesis in a mouse model of HSV-1 infection. IMPORTANCE HSV-1 is a major human pathogen that infects ∼80% of the human population and can be life threatening to infected neonates or immunocompromised individuals. Effective therapies for treatment of recurrent HSV-1 infections are limited, which emphasizes a critical need to understand in

SIMPUL-SIMPUL PENDIDIKAN DALAM SURAH AL ANFÂL DAN AL TAUBAH

Directory of Open Access Journals (Sweden)

Noorazmah Hidayati

2013-10-01

Full Text Available Today, concept of jihad disposed wrong to be understood. Jihad mean as a war, even must destroyed some people and creatures with in the name of Islam. As a consequence Islam refer to a terorist religion. This opinion must be corrected, because Islam is “rahmatan lil ‘alamiin”. In fact, in independent time jihad should be manifested to protect equitable and moral of humanbeing. This article describes some essences of education of jihad in surah al Anfâl and al Taubah with the result that every action will valued as jihad and humanbeing values will protected.

Venture from the Interior-Herpesvirus pUL31 Escorts Capsids from Nucleoplasmic Replication Compartments to Sites of Primary Envelopment at the Inner Nuclear Membrane.

Science.gov (United States)

Bailer, Susanne M.

2017-11-25

Herpesviral capsid assembly is initiated in the nucleoplasm of the infected cell. Size constraints require that newly formed viral nucleocapsids leave the nucleus by an evolutionarily conserved vescular transport mechanism called nuclear egress. Mature capsids released from the nucleoplasm are engaged in a membrane-mediated budding process, composed of primary envelopment at the inner nuclear membrane and de-envelopment at the outer nuclear membrane. Once in the cytoplasm, the capsids receive their secondary envelope for maturation into infectious virions. Two viral proteins conserved throughout the herpesvirus family, the integral membrane protein pUL34 and the phosphoprotein pUL31, form the nuclear egress complex required for capsid transport from the infected nucleus to the cytoplasm. Formation of the nuclear egress complex results in budding of membrane vesicles revealing its function as minimal virus-encoded membrane budding and scission machinery. The recent structural analysis unraveled details of the heterodimeric nuclear egress complex and the hexagonal coat it forms at the inside of budding vesicles to drive primary envelopment. With this review, I would like to present the capsid-escort-model where pUL31 associates with capsids in nucleoplasmic replication compartments for escort to sites of primary envelopment thereby coupling capsid maturation and nuclear egress.

METODE DAN TEKNIK BIMBINGAN KONSELING ISLAMI UNTUK MEMBANTU PERMASALAHAN PADA ANAK-ANAK

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Atikah Atikah

2015-08-01

Full Text Available Perkembangan pada usia anak akan mempengaruhi perkembangan pada fase berikutnya.  Jika  anak usia dini dalam pengasuhan yang benar dan sesuai dengan karakter anak maka akan mampu menghadapi tugas perkembangan (task development berikutnya, dan akan sebaliknya ketika anak usia dini dalam pengasuhan yang salah atau perlakuan yang salah pada anak (child abuse. Sehingga dibutuhkan pemahaman tentang usia anak,  lengkap dengan karakteristik-kebutuhan-permasalahan untuk membantu tumbuh kembang anak agar optimal sesuai dengan tahapan kemampuan yang harus dimiliki anak. Cara-cara membantu masalah yang sering dialami anak-anak disesuaikan dengan tahapan usia. Ciri khas pada anak adalah bermain dan bergembira, sehingga anak-anak dapat menyelesaikan masalah yang sering muncul dengan suasana senang dan ceria. Memahamkan anak-anak tentang penyelesaian masalah juga diperlukan agar siap menghadapi permasalahan dengan kemampuan yang dimiliki. Salah satu teknik dalam metode kelompok yaitu karyawisata. Dengan mengunjungi tempat-tempat wisata,  memberi kesempatan pada anak-anak berganti situasi (rutinitas ke obyek wisata untuk mengatasi masalah dengan tetap bersenang-senang bermain. Sehingga permainan di tempat obyek wisata akan memberikan dampak kesegaran fisik  dan beban- beban masalah yang terjadi terbantukan dengan mengalihkan ke permainan yang di setting untuk membantu pemecahan masalah. Dan teknik-teknik bimbingan konseling Islam yang lainnya dapat digunakan untuk menyelesaikan sesuai dengan berbagai macam permasalahan. kata kunci: Metode Bimbingan  Konseling, Konseling Islami, Permasalahan Anak METHODS AND TECHNIQUES TO HELP THE ISLAMIC GUIDANCE COUNSELING PROBLEMS IN  CHILDREN. Development of the child’s age will affect the development of the next phase. If early childhood in the care of the correct and in accordance with the character of the child will be able to face the developmental task(taskdevelopmentnext,  and will instead when early

The ribosomal protein uL22 modulates the shape of the nascent protein exit tunnel

DEFF Research Database (Denmark)

Wekselman, I.; Zimmerman, E.; Davidovich, C.

2017-01-01

in the entrance of theribosomal exit tunnel and interferes with the progression of nas-cent chains. Commonly, resistance to erythromycin is acquiredby alterations of rRNA nucleotides that interact with the drug.Mutations in theb-hairpin of ribosomal protein uL22, which israther distal to the erythromycin binding...... to erythromycin binding pocket and increases its flexi-bility. Based on our results, we suggest a feasble mechanism thatexplains how nanscent proteins can be translated when ery-thromycin is bound to the ribosome. Furthermore, our findingssupport recent studies showing that the interactions betweenuL22...

Visual analysis and Schmidt rebound hammer test of Taj-ul-Masajid

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A. Hussain

2017-09-01

Full Text Available Taj-ul-Masajid, literally, the crown among mosques is an embodiment of genius structural engineering located in the heart of Madhya Pradesh, Bhopal. A unique combination of the Mughal Architecture in complete stone masonry and modern day RCC work, it is a liaison between the past and the present of structural engineering. A wonder in its own right, the structure is often neglected by technicians and conservationalists alike, a satire on their ingenuity. Now, in a severely dilapidated condition, the structure is in pressing need of structural rehabilitation. The authors intend to perform in-situ Non-Destructive Testing & Evaluation (NDT&E of this structure and thereby suggest steps to better its present condition. As a first step, they’ve performed the visual analysis and Schmidt Rebound Hammer Test on the concrete portion of the structure which has been presented herein. The authors have also suggested a new approach for the verification of results obtained.

Africa’s Irregular Security Threats: Challenges for U.S. Engagement (Strategic Forum, Number 255, May 2010)

Science.gov (United States)

2010-05-01

Islamic Maghreb (AQIM) franchise based in Algeria and northern Mali, and the Harakat al-Shabab network based in southern Somalia.13 In North and West...point of launching a terrorist bombing attack at the Planet Hollywood restaurant in Cape Town in August 1998. This shift toward the informal and

Resource Allocation and Interference Management for D2D-Enabled DL/UL Decoupled Het-Nets

KAUST Repository

Celik, Abdulkadir

2017-10-06

In this paper, resource allocation and interference mitigation are investigated for heterogeneous networks (HetNets) where the lowest tier consists of device-to-device (D2D) cells. In order to alleviate dead-zone problem, we first consider downlink/ uplink (DL/UL) decoupling (DUDe) user association and quantify its capability on interference management and networkwide D2D performance enhancement. Secondly, we propose an UL fractional frequency reuse (FFR) scheme where subband (SB) bandwidths are adaptively determined based on: i) user equipment (UE) density, ii) e-node-B (eNB) density, and iii) ON/OFF switching frequency of smallcells. Obtained results show that the adaptive method significantly reduces the number of outage users. Thereafter, a novel concatenated bi-partite matching (CBM) method is proposed for joint SB assignment (SA) and resource block allocation (RA) of cellular UEs (CUEs). Numerical results show that the CBM provides a close performance to exhaustive solution with greatly reduced running time. The CBM is then extended to a centralized mode selection, SA, and RA for D2D cells. Alternatively, we develop offline and online semidistributed approaches where a D2D-cell can reuse white-list RBs (WRBs), which are not occupied by the adjacent smallcells. In the former, D2D-cell members are not aware of intra-cell and inter-cell interference and uniformly distribute their maximum permissible power to WRBs. In the latter, we put D2D sumrate maximization into a convex form by exploiting the proximity gain of D2D UEs (DUEs). Online distributed solution is then developed by message passing of dual variables and consistency prices. Finally, virtues and drawbacks of the developed approaches are compared and explained.

Resource Allocation and Interference Management for D2D-Enabled DL/UL Decoupled Het-Nets

KAUST Repository

Celik, Abdulkadir; Radaydeh, Redha Mahmoud Mesleh; Al-Qahtani, Fawaz S.; Alouini, Mohamed-Slim

2017-01-01

In this paper, resource allocation and interference mitigation are investigated for heterogeneous networks (HetNets) where the lowest tier consists of device-to-device (D2D) cells. In order to alleviate dead-zone problem, we first consider downlink/ uplink (DL/UL) decoupling (DUDe) user association and quantify its capability on interference management and networkwide D2D performance enhancement. Secondly, we propose an UL fractional frequency reuse (FFR) scheme where subband (SB) bandwidths are adaptively determined based on: i) user equipment (UE) density, ii) e-node-B (eNB) density, and iii) ON/OFF switching frequency of smallcells. Obtained results show that the adaptive method significantly reduces the number of outage users. Thereafter, a novel concatenated bi-partite matching (CBM) method is proposed for joint SB assignment (SA) and resource block allocation (RA) of cellular UEs (CUEs). Numerical results show that the CBM provides a close performance to exhaustive solution with greatly reduced running time. The CBM is then extended to a centralized mode selection, SA, and RA for D2D cells. Alternatively, we develop offline and online semidistributed approaches where a D2D-cell can reuse white-list RBs (WRBs), which are not occupied by the adjacent smallcells. In the former, D2D-cell members are not aware of intra-cell and inter-cell interference and uniformly distribute their maximum permissible power to WRBs. In the latter, we put D2D sumrate maximization into a convex form by exploiting the proximity gain of D2D UEs (DUEs). Online distributed solution is then developed by message passing of dual variables and consistency prices. Finally, virtues and drawbacks of the developed approaches are compared and explained.

Mobile platform for fish migration upstream from the discharge sill situated near Dacia bridge on Crișul Repede River

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Răzvan VOICU

2016-06-01

Full Text Available Longitudinal connectivity represent the way in which organisms move the energy and material exchanges located throughout the water. Fragmentation the longitudinal connectivity of watercourses caused by dams or other hydrotechnical constructions represent a major impact on sediment transport, hydrological regime, downstream moving and biota migration. The hydromorphological elements (river continuity, as well as chemical, biological, physicochemical elements characterize the ecological status of rivers. Migratory fish species: nase (Chondrostoma nasus - protected by Bern Convention - Appendix III, barbel (Barbus barbus - rare species, protected Habitats Directive (Annex V, annex 4A of Low nr.462 and Red List of RBDD and Freshwater bream (Abramis brama - protected by Bern Convention (Appendix III are blocked by the hydrotechnical constructions (discharge sills, dams located across the watercourse Crișul Repede River. One of the important think of this system is the gravitational fall of water. This solution will lead to the restoration of the longitudinal connection of the Crișul Repede River in the Oradea City, near Dacia Bridge. Romania is part of the European Union and it has the obligation to implement the provisions of the Water Framework Directive 2000/60/EC, transposed into Romanian legislation by the Water Law 107/1996 as supplemented and amended (Act 310/2004.

Nonstate Security Threats in Africa: Challenges for U.S. Engagement

Science.gov (United States)

2010-12-01

franchise based in Algeria and north- ern Mali, and the Harakat al-Shabab network based in southern Somalia.13 In North and West Africa, AQIM is the...instance, ele- ments of PAGAD became radicalized to the point of launching a terrorist bombing attack at the Planet Hollywood restaurant in Cape Town in

Aplikasi Hermeneutika Nashr Hāmid Abū Zaid Terhadap Hadis Nabi (Studi Pada Hadis “Perintah Memerangi Manusia Sampai mereka Mengucapkan tiada tuhan selain Allah”

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Mohamad Nuryansah

2016-12-01

Full Text Available This paper aims to understand the meaning of jihad in the present context by re-reading the hadith about “the command to fight against human until they say there is no god but Allah." The re-reading to this hadith need to do continuously, because in present context, there are a lot of violences on behalf of religious texts both derived from Qur'an and hadith. Theory used to understand the hadith is hermeneutical theory by Nasr Hamid Abu Zaid. The hermeneutic of Nasr Hamid Abu Zaid consists of three main pillars, namely finding the dalalah (meaning, magza (significance and maskut anhu (unspoken dimensions of the text. Based on the application of the hermeneutic, it is obtained the results that dalalah of jihad implied in Hadith is that jihad in peace way is more emphasized; while magza (significance of the hadith is instructing that Jihad in Islamic view is only in decent way and maskut anhu (unspoken dimensions of the Hadith is that violent jihad is prohibited.

ORGANIZATIONAL COMMITMENT AS THE BLACK BOX TO CONNECT THE ISLAMIC WORK ETHICS AND EMPLOYEES BEHAVIOR TOWARD ORGANIZATIONAL CHANGE

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Sri Wartini

2014-09-01

Full Text Available The objective of the study was to examine the direct and indirect influences of Islamic work ethics on employees behavior toward organization change with organizational commitment as mediation. The population of the study was Public Civil Servants of the general inspectors of finance ministry. The samples were taken by Solvin method. It was a purposive sampling with 87 respondents. The results of the study showed that there was a direct influence of Islamic work ethics on organizational commitment, there was not any direct influence of organizational commitment on employees behavior toward organizational change, there was an indirect influence of Islamic work ethics on employees behavior toward organization change with organizational commitment as the mediation. It is concluded that there were a direct and an indirect influences of Islamic work ethics on employees behavior toward organizational commitmen as the mediation. Tujuan penelitian ini untuk menguji pengaruh langsung dan tidak langsung etika kerja Islami pada perilaku karyawan terhadap perubahan organisasi dengan komitmen organisasional sebagai mediasi. Populasi dalam penelitian ini adalah karyawan Pegawai Negeri Sipil di Itjen Kementerian Keuangan RI sebanyak 87 responden, menggunakan metode Slovin dengan teknik Purposive Sampling. Berdasarkan hasil penelitian menunjukkan, bahwa terdapat pengaruh langsung etika kerja Islami pada komitmen organisasional, tidak terdapat pengaruh langsung komitmen organisasional pada perilaku karyawan terhadap perubahan organisasi, terdapat pengaruh langsung etika kerja Islami pada perilaku karyawan terhadap perubahan organisasi dan terdapat pengaruh etika kerja Islami pada perilaku karyawan terhadap perubahan organisasi dengan komitmen organisasional sebagai mediasi. Penelitian ini menyimpulkan, bahwa ada pengaruh langsung dan tidak langsung etika kerja Islami pada perilaku karyawan terhadap perubahan organisasi dengan komitmen organisasional sebagai

Daniel Pipes: saabuvad kriisid näitavad Euroopa arengusuunda / Daniel Pipes ; interv. Iivi Anna Masso

Index Scriptorium Estoniae

Pipes, Daniel

2008-01-01

Lähis-Ida uurija vastab küsimustele, mis puudutavad Iisraeli mainet, Hamasi ja Fatahi konflikti, Iisraeli ja palestiinlaste konflikti, islami ja islamismi erinevust, islamofoobia mõistet, tema ennustust islami ja Euroopa suhete kohta, sõnavabadust, vaenlast terrorismivastases sõjas, uuskonservatiivsuse mõistet, Euroopa Liitu, USA tulevaste presidendivalimiste tulemuse mõju maailmale. Uurija on seisukohal, et Euroopa ja seal elavate muslimite vahelistes suhetes kriisi ärahoidmiseks peaks Euroopa muslimid tõeliselt integreerima

Islam ja Tallinn - kontaktid minevikust tänaseni / Toomas Abiline

Index Scriptorium Estoniae

Abiline, Toomas

2007-01-01

Eesti tõsisem kokkupuude islamiga toimus Liivi sõja päevil, kui vabanemaks alandavast alluvussuhtest Ivan IV-ga, tulid paljud tatarlased sõja käigus Rootsi poole üle ja osa neist jäi Eestisse elama. Esimene suurem islami kogukond tekkis Eestis pärast Eesti- ja Liivimaa liitmist Vene tsaaririigiga 1721. aastal. Esimese maailmasõja ja Vabadussõja aastatel lahkusid Eestist paljud tatarlased. Eesti Islami Kogudus taasregistreeriti 1989. aastal

Linear uranium complexes X2UL5 with L=cyanide, iso-cyanate: DFT evidence for similarities between uranyl (X = O) and uranocene (X = Cp) derivatives

International Nuclear Information System (INIS)

Iche-Tarrat, N.; Marsden, Colin J.; Barros, N.; Maron, L.; Barros, N.

2008-01-01

A DFT study of the isostructural compounds [UO 2 L 5 ] n- with n=3-5 and linear [Cp 2 UL 5 ] m- with m=1-3 has been carried out for two different anionic ligands. Structurally stable structures are obtained for all systems. The coordination competition between cyanide (CN - ) and isocyanide (NC - ) as well as between cyanate (OCN - ) and iso-cyanate (NCO - ) has been studied in the uranyl case. A clear preference for cyanide and iso-cyanate complexes is reported. The coordination of five ligands in the equatorial plane is rationalized by the analysis of the MO diagram of both systems. Moreover, the qualitative comparison of the two MO diagrams shows a high similarity in agreement with the isolobality concept. The existence of linear [Cp 2 UL 5 ] - organometallic U(VI) complexes is thus proposed, as well as the possibility of obtaining complexes of both types for U(VI) and U(V) with OCN - ligands. In addition, the U(IV) linear metallocene is calculated to be stable for the latter ligand. (authors)

Validation of the FACT-B+4-UL questionnaire and exploration of its predictive value in women submitted to surgery for breast cancer.

Science.gov (United States)

Andrade Ortega, Juan Alfonso; Millán Gómez, Ana Pilar; Ribeiro González, Marisa; Martínez Piró, Pilar; Jiménez Anula, Juan; Sánchez Andújar, María Belén

2017-06-21

The early detection of upper limb complications is important in women operated on for breast cancer. The "FACT-B+4-UL" questionnaire, a specific variant of the Functional Assessment of Cancer Therapy-Breast (FACT-B) is available among others to measure the upper limb function. The Spanish version of the upper limb subscale of the FACT-B+4 was validated in a prospective cohort of 201 women operated on for breast cancer (factor analysis, internal consistency, test-retest reliability, construct validity and sensitivity to change were determined). Its predictive capacity of subsequent lymphoedema and other complications in the upper limb was explored using logistic regression. This subscale is unifactorial and has a great internal consistency (Cronbach's alpha: 0.87), its test-retest reliability and construct validity are strong (intraclass correlation coefficient: 0.986; Pearson's R with "Quick DASH": 0.81) as is its sensitivity to change. It didn't predict the onset of lymphedema. Its predictive capacity for other upper limb complications is low. FACT-B+4-UL is useful in measuring upper limb disability in women surgically treated for breast cancer; but it does not predict the onset of lymphoedema and its predictive capacity for others complications in the upper limb is low. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

Risks of radicalization among Turkish-Dutch young adults?

NARCIS (Netherlands)

R.H.J.M. Staring (Richard)

2014-01-01

markdownabstract__Abstract__ Young adults heading for Syria to join the jihad and the safety risks associated with their return are currently a topic of debate in the Netherlands and in many other European countries. Around 120 Dutch citizens have gone abroad to join the jihad and the Dutch

Nietzsche l'islam et la globalisation

African Journals Online (AJOL)

17 déc. 2013 ... Obscurantism, Islam, jihad, theocracy dominate . The century in fact expresses a new concept of postmodern revolutions or the society is in intersection between philosophy, politics and religion. The three pillars of all social facts. Keywords: revolution, Islam, globalisation, democracy, jihad, will for power.

USING THE FOURNIER INDEXES IN ESTIMATING RAINFALL EROSIVITY. CASE STUDY - THE SECAŞUL MARE BASIN

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M. COSTEA

2012-03-01

Full Text Available Using the Fournier Index in Estimating Rainfall Erosivity. Case Study - The Secaşul Mare Basin. Climatic aggressiveness is one of the most important factors in relief dynamic. Of all climatic parameters, rainfall is directly involved in versant dynamic, in the loss of soil quality and through pluvial denudation and the processes associated with it, through the erosivity of torrential rain. We analyzed rainfall aggressiveness based on monthly and annual average values through the Fournier's index (1970 and Fournier's index modified by Arnoldus (1980. They have the advantage that they can be used not only for evaluating the land susceptibility to erosion and the calculation of erodibility of land and soil losses, but also in assessing land susceptibility to sliding (Aghiruş, 2010. The literature illustrates the successful use of this index which provides a summary assessment of the probability of rainfall with significant erosive effects. The results obtained allow observation of differences in space and time of the distribution of this index.

ISLAM DAN RADIKALISME: Telaah atas Ayat-ayat “Kekerasan” dalam al-Qur’an

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Dede Rodin

2016-02-01

Full Text Available The discouse of radicalism in all religions always presenting the name of God. This is understandable because religion has a strong authority over various other strength. Including Islam, which since the beginning has declared itself as a peace religion, his teachings by some people often used as justification for violent acts. One of the reasons is the missunderstanding of the verses of Qur’an and the traditions of the Prophets of jihad and war (qital. This article aims to review these verses with regard to the meaning and historical context that result the correct and comprehensive understanding. This article concludes that jihad and war (qital in the Qur’an is different from the act of radicalism. The main purpose of jihad is human welfare and not warfare. So, jihad is the duty of every muslim throughout his life, while war (qital is conditional, temporal, and as a last attempt after no other way except the physical resistance. Besides the implementation of the war also must meet various requirements are very stringent.

Sa Rocca Ulàri Cave, near S. Pietro di Sorres, Borutta (SS: archaeological aspects.

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Pier Paolo Soro

2009-12-01

Full Text Available The Cave of Sa Rocca Ulàri, in the municipality of Borutta (SS, is fully inserted into the dense settlement of the natural cavities of Sardinia during the prehistory and early history. Its size and the particular relation to the configuration of the land in relation to the richness of the Mejlogu landscape, allowed small groups of people to settle in the cavity that opens into the northern slope of the Hill of Sorres. Attendance could be certified without interruption from the Neolithic until the Middle Ages. The preliminary study of materials, has determined that the most popular period for residential purposes is referring to the end of the Neolithic culture of Ozieri, and the first Eneolithic Sub Ozieri. The funerary use is assumed for the subsequent cultural phases Monte Claro (Evolved Eneolithic and Bonnanaro I facies Corona Moltana (Bronze Age. In the Nuragic Era (Middle Bronze / Late / Final and early Iron Age the cavity was initially used for storing food, then for other purposes probably linked to the cult.

NNLO corrections to anti B {yields} X{sub u}l anti {nu} in the shape-function region

Energy Technology Data Exchange (ETDEWEB)

Asatrian, H.M. [Erevanskij Fizicheskij Inst., Erevan (Armenia); Greub, C. [Bern Univ. (Switzerland). Inst. for Theoretical Physics; Pecjak, B.D. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

2008-10-15

The inclusive decay anti B {yields} X{sub u}l anti {nu} is of much interest because of its potential to constrain the CKM element vertical stroke V{sub ub} vertical stroke. Experimental cuts required to suppress charm background restrict measurements of this decay to the shape-function region, where the hadronic final state carries a large energy but only a moderate invariant mass. In this kinematic region, the differential decay distributions satisfy a factorization formula of the form H.J x S, where S is the non-perturbative shape function, and the object H.J is a perturbatively calculable hard-scattering kernel. In this paper we present the calculation of the hard function H at next-to-next-to-leading order (NNLO) in perturbation theory. Combined with the known NNLO result for the jet function J, this completes the perturbative part of the NNLO calculation for this process. (orig.)

Jihād and Islamic arms and armour

Directory of Open Access Journals (Sweden)

Alexander, David

2002-12-01

Full Text Available This article studies the islamic concept of Jihad or Holy war and its differents implications on the decoration of arms and armour.

Este artículo trata el concepto islámico de Jihad o Guerra Santa y sus diversos implicaciones trasladadas a la decoración de las armas y armaduras.

Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141.

Directory of Open Access Journals (Sweden)

Jye-Lin Hsu

2015-04-01

Full Text Available Human cytomegalovirus (HCMV US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through downregulation of MHC class I molecules (MHC-I. Here we show that US2 function goes far beyond MHC-I degradation. A systematic proteomic study using Plasma Membrane Profiling revealed US2 was unique in downregulating additional cellular targets, including: five distinct integrin α-chains, CD112, the interleukin-12 receptor, PTPRJ and thrombomodulin. US2 recruited the cellular E3 ligase TRC8 to direct the proteasomal degradation of all its targets, reminiscent of its degradation of MHC-I. Whereas integrin α-chains were selectively degraded, their integrin β1 binding partner accumulated in the ER. Consequently integrin signaling, cell adhesion and migration were strongly suppressed. US2 was necessary and sufficient for degradation of the majority of its substrates, but remarkably, the HCMV NK cell evasion function UL141 requisitioned US2 to enhance downregulation of the NK cell ligand CD112. UL141 retained CD112 in the ER from where US2 promoted its TRC8-dependent retrotranslocation and degradation. These findings redefine US2 as a multifunctional degradation hub which, through recruitment of the cellular E3 ligase TRC8, modulates diverse immune pathways involved in antigen presentation, NK cell activation, migration and coagulation; and highlight US2's impact on HCMV pathogenesis.

The Conservation Measures of NATURA 2000 "Someşul Rece" Site Management Plan

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Marian Proorocu

2016-11-01

Full Text Available Natura 2000 is a European network of protected natural areas including a significant number of natural habitats and wild species for the interest of comunnity. Natura 2000 ROSCI 0233 "Someşul Rece"  Site is situated in the south-western county of Cluj, on the administrative territory of Măguri-Răcătău and Ierii Valley. It has an area of 8529 ha and is a framed area of the Apuseni Mountains Alpine bioregions. The site preserves the following natural habitats: Rough mountain beech forests Asperulo-Fagetum, beech forests of Luzulo-Fagetum, forests acidophilous Picea Abies mountain region and protect important species and active fish fauna, flora and fauna of the Apuseni Mountains. It is also home for several species (mammals, amphibians, fish and beetles like: lynx, wolf or otter. The conservation measures of Natura 2000 Somesul Rece Site, elaborated in order to protect the habitats and the species are part of the management plan. These measures were developed in close connection with the conservation status of habitats and species, but also taking into account the needs of local communities. These measures include: maintaining habitats in favorable conservation status; maintain the current habitat areas; preventing and combating poaching and overfishing;ensuring peace in areas of rock (for large mammals.

Standard model Wilson coefficients for c → ul{sup +}l{sup -} transitions at next-to-leading order

Energy Technology Data Exchange (ETDEWEB)

Boer, Stefan de [TU Dortmund (Germany); Mueller, Bastian; Seidel, Dirk [Uni Siegen (Germany)

2016-07-01

The standard theoretical framework to deal with exclusive, weak decays of heavy mesons is the so-called weak effective Hamiltonian. It involves the short-distance Wilson coefficients, which depend on the renormalization scale μ. For specific calculations one has to evolve the Wilson coefficients down from the electroweak scale μ{sub W} to the typical mass scale of the decay under consideration. This is done by solving a renormalization group equation for the effective operator basis. In this talk the results of a consistent two-step running of the c → ul{sup +}l{sup -} Wilson coefficients are presented. This running involves the intermediate scale μ{sub b} (with μ{sub W} > μ{sub b} > μ{sub c}) where the bottom quark is integrated out. All the matching coefficients and anomalous dimensions are taken to the required order by generalizing and extending results from b → s or s → d transitions available in the literature.

Islam arvustab, laieneb, mõjutab / Toomas Alatalu

Index Scriptorium Estoniae

Alatalu, Toomas, 1942-

2003-01-01

Malaisia peaministri Mohamad Mahathiri kõnest islamiriikide tippkonverentsil, kus ta kritiseeris juute. Venemaa presidendi Vladimir Putini osalemisest vaatlejana Islami Konverentsi Organisatsiooni Putrajaya konverentsil

Islam ja terror samas lauses? / Iivi Anna Masso

Index Scriptorium Estoniae

Masso, Iivi Anna, 1967-

2011-01-01

Seostest islami ja islamistlike terroristide vahel. Araabia maailma raputavatest rahutustest. Terrosimiaktidest Venemaal. Autori hinnangul aitaks suhtumine islamisse terve kriitikaga paremini mõista muslimitest libaraale

Radical Islam in East Africa

Science.gov (United States)

2009-01-01

Initiative EIJ Egyptian Islamic Jihad EIJM Eritrean Islamic Jihad Movement EPLF Eritrean People’s Liberation Front FPENS Formal Private Education Network in...ceremonies, the siyaaro or pilgrimages to the tombs of saints (practiced in particular by Sufis), and the celebration of Mawliid (the Prophet... tombs become pil- grimage centers.17 An important Sufi-linked organization is Ahlu Sunna wal-Jama’a (ASWJ), which seeks to unify the Sufi community

Euroopa tulevikuvisiooni näeme Ceutas ja Melillas / Daniel Pipes ; intervjueerinud Taavi Minnik

Index Scriptorium Estoniae

Pipes, Daniel

2016-01-01

Intervjuu Lähis-Ida Foorumi presidendi Daniel Pipesiga Euroopa migratsioonikriisist ja vigadest migratsioonipoliitikas. Probleemidest, mida massiimmigratsioon Kolmandast Maailmast Euroopale kaasa toob ning radikaalse islami ohtudest

Terror: Social Media and Extremism

Science.gov (United States)

2014-05-01

lists the 39 principles of jihad. One of the principles is, " performing electronic jihad.ř The principle describes cybercrime and cyber vandalism...attack on the Boston Marathon . A lesser-known case study of self-radicalization from YouTube is Roshanara Choudhry, a British woman who stabbed a Member...done in social media to counter the extremists. A recreation of USIA with a modern spin for the technology of today could vastly improve the US

Popular Religiosity in Indonesia Today: The Next Step after ‘Islam Kultural’?

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Farish A. Noor

2015-12-01

[Fenomena Islam popular terlihat di mana-mana di dunia Islam saat ini, dan itu diekspresikan lewat berbagai media seperti tata busana sampai arsitektur, juga termasuk aturan-aturan yang dianggap Islami. Pada kasus Indonesia, perkembangan trend halal-haram yang dimotori oleh dunia tata busana dan kosmetik menyebabkan munculnya kelas menengah baru yang membawa aspirasi itu ke atas sebagai modal. Makalah ini menempatkan Islam popular di Indonesia pada jangka panjang dan luas sebagai fenomena yang layak dijadikan bahan studi; begitu juga arah perkembangan di negara itu. Namun tidak semua di bawah kategori ini masuk dalam wilayah Islamis, namun tetap saja menunjukkan kesadaran keagamaan baru di perkotaan pada kelas menengah yang menganggap dirinya sebagai agen perubahan dan juga penggiat ekonomi agamis].

Pendidikan Hati Perspektif al-Ghazālī dalam Kitab Ihya’ Ulūm al-Dīn

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Muhammad Hasyim

2017-09-01

Full Text Available Al-Ghazālī in Sufism has had big influenced of his thought in the world. He was Syafi’i follower in fiqih law and Asy’ariyah in theology, when he was in Baghdad he hung out with many mazhabs. Ihya’ Ulūm al-Dīn is outlined with sharp thought method. The discussion is divided to systematic parts. It combined outward and inner fiqh, in explaining the difficult terms, this book uses tamstil. Al Ghazali has written heart diseases and its medicine. It also inserted many advantage stories as refreshing phase. Heart education is the soul controlling process. This soul consequently is able to encourage the physical activity in daily life appropriate with syari’ah of Allah through riyadhoh, fasting, praying or other worships. It also makes person becomes obidient people from birth to death, through many education and teaching and learning gradually, in which the learning peocess is parents and society responsibility toward a pious (shalih person. The purpose of psychology according to Ghazali is forming pious or shalih people.

Moskva gotova k peregovoram s HAMAS / Marianna Belenkaja

Index Scriptorium Estoniae

Belenkaja, Marianna

2006-01-01

Venemaa presidendi Vladimir Putini kavatsusest kutsuda läbirääkimistele hiljutised Palestiina parlamendivalimised võitnud islami vastupanuliikumise Hamas juhid. Põhjused, mis sunnivad Venemaad dialoogile Hamas'iga

Further Characterization of the UL37 Protein of Herpes Simplex Virus Type 1 and its Interaction with ICP8, the Major DNA-Binding Protein of Herpes Simplex Virus

Science.gov (United States)

1994-01-01

Baringer, J.R. 1974. Recovery of herpes simplex virus from human sacral ganglions. N. Eng!. J. Med. 291:828-830. Baringer, J.R. 1976. The biology of herpes ...UL37 Protein of Herpes Simplex Virus Type 1 and its Interaction with [CPS, the Major DNA~Binding Protein of Herpes Simplex Virus" beyond brief...Protein of Herpes Simplex Virus Type 1 and its Interaction with [CPS, the Major DNA-Binding Protein of Herpes Simplex Virus Allen G. Albright Doctor of

Two loop virtual corrections to b → (d, s)l{sup +}l{sup -} and c → ul{sup +}l{sup -} for arbitrary momentum transfer

Energy Technology Data Exchange (ETDEWEB)

Boer, Stefan de [TU Dortmund, Fakultaet fuer Physik, Dortmund (Germany)

2017-11-15

Non-factorizable two loop corrections to heavy to light flavor changing neutral current transitions due to matrix elements of current-current operators are calculated analytically for arbitrary momentum transfer. This extends previous work on b → (d, s)l{sup +}l{sup -} transitions. New results for c → ul{sup +}l{sup -} transitions are presented. Recent work on polylogarithms is used for the master integrals. For b → sl{sup +}l{sup -} transitions, the corrections are most significant for the imaginary parts of the effective Wilson coefficients in the large hadronic recoil range. Analytical results and ready-to-use fitted results for a specific set of parameters are provided. (orig.)

Religious Extremism in Pakistan

Science.gov (United States)

2014-12-01

Jessica Stern, “Pakistan’s Jihad Culture ,” Foreign Affairs 79, no. 6 (November–December 2000): 115‒126, http://www.jstor.org/stable/20049971; see also...Pakistan’s Jihad Culture ,” Foreign Affairs 79, no. 6 (November‒December 2000): 115‒126, http://www.jstor.org/stable/20049971; Religions and Development...after the JUD was implicated in the Mumbai attack in 2008, protesting that the organization was a charity that helped them by providing food and water

MENATA RUMAH YANG ISLAMI

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Hafidz Zamroni Zien, Tarranita Kusumadewi

2012-06-01

An Islamic house is not always designed like mosques or houses which are full of Islamic ornaments, such as calligraphy, and more. An Islamic house is an efficient house which can be used to  dhikr to Allah, and to remember death. The house is not always facing the Qibla or the lavatory was not facing Mecca. An Islamic house is a house that allows occupants to stay and interact with others. Besides, the privacy of each person can also be maintained in it. It is then becoming the task of the architects to make Islamic houses. However, the most important thing of an Islamic house is that it does not isolate the occupants from the outside world. Further, it could create a better interaction and social relationship with its surroundings and neighbors. Key words: Islamic House, rules, adab

DAKWAH ISLAM DAN RADIKALISME AGAMA

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M. Isfironi M. Bisri Djalil

2016-07-01

Full Text Available ABSTRACT A thing closely related to bustle the life of the religious contemporary is radicalism phenomenon. The question is: Does Islam teach radicalism? The answer of this question always problematic. It is caused by every religion (either Islam or the other viewed as an acceptance that granted as a divinity instrument that teaches everything in goodness. Islam is a religion that provide of security, comfort, calmness as more strengthening for all its adherents. In Indonesia, radical Islamic groups often associated with groups like company of Salafy (Bandung, Islamic Youth Front (FPIS, Islamic Defender Front (FPI, Jihad’s Troop of Ahlus Sunnah Wal Jama’ah, The Tribunal of Indonesian Mujahidin, Hizbut Tahrir of Indonesia. The movement of Islam in Indonesia cannot be viewed as a monolithic movement or uniform in the same of political interest. That moment, political global movement has variation in the perspective, motive, strategy and action. One thing that same as the source of radicalism is the definition of the concept of jihad. Eventually, the construction of jihad affects the Islamic propaganda (dakwah ideology and movement. Ideally the realization of the concept of Jihad is not led to radicalism. If indeed reflect to the era of the Prophet Muhammad (pbuh, then it must be conceived with the conditions encountered at that time.   Key Words: Islamic Propaganda, Jihad, Radicalism

America : It's not always about you / Gwynne Dyer

Index Scriptorium Estoniae

Dyer, Gwynne

2004-01-01

Autor kritiseerib ameeriklaste ekslikku arusaama, mille kohaselt on islami terroristide tegevus suunatud eelkõige Ameerika Ühendriikide demokraatia ja heaoluühiskonna vastu ning selgitab islamiterrorismi reaalseid eesmärke

The Trans-Sahara Counterterrorism Partnership: Strategy and Institutional Friction

Science.gov (United States)

2011-03-22

unauthorized commitments‖ (e.g., making a verbal contract to set up a banquet at an Iranian restaurant for $2,000) because they are illegal under...East Report N°29, 30 July 2004, 14 25 13 Ibid. 14 Lianne Kennedy-Boudali, ―The GSPC: Newest Franchise in al-Qa‘ida‘s Global Jihad,‖ The... Franchise in al-Qa‘ida‘s Global Jihad,‖ and Hanson and Vriens for estimates of GIA, GSPC and AQIM numbers. 25 Ibid. 26 Dario Cristiani, ―Algeria‘s

Development and evaluation of an immunochromatographic strip test based on the recombinant UL51 protein for detecting antibody against duck enteritis virus

Directory of Open Access Journals (Sweden)

Sun Tao

2010-10-01

Full Text Available Abstract Background Duck enteritis virus (DEV infection causes substantial economic losses to the worldwide duck-producing areas. The monitoring of DEV-specific antibodies is a key to evaluate the effect of DEV vaccine and develop rational immunization programs. Thus, in this study, an immunochromatographic strip (ICS test was developed for detecting DEV serum antibodies. Results The ICS test is based on membrane chromatography, and uses both the purified recombinant UL51 protein conjugated with colloidal gold and goat anti-rabbit IgG conjugated with colloidal gold as tracers, the purified recombinant UL51 protein as the capture reagent at the test line, and rabbit IgG as the capture reagent at the control line. The specificity of the ICS was evaluated by sera against DEV, Duck hepatitis virus (DHV, Riemerella anatipestifer (RA, Duck E. coli, Muscovy duck parvovirus (MPV, or Duck Influenza viruses (DIV. Only sera against DEV showed the strong positive results. In order to determine the sensitivity of the ICS, anti-DEV serum diluted serially was tested, and the minimum detection limit of 1:128 was obtained. The ICS components, which are provided in a sealed package, require no refrigeration and are stable for 12 months. To evaluate the effect of the ICS, 110 duck serum samples collected from several non-immune duck flocks were simultaneously tested by the ICS test, enzyme-linked immunosorbent assay (ELISA and neutralization test (NT. The results showed that the sensitivity of the ICS test was almost consistent with ELISA and much higher than NT, has low cost, and is rapid (15 min and easy to perform with no requirement of specialized equipment, reagent or technicians. Conclusions In this work, we successfully developed a simple and rapid ICS test for detecting DEV serum antibodies for the first time. The ICS test was high specific and sensitive for the rapid detection of anti-DEV antibodies, and has great potential to be used for the serological

Norra moslemite juht soovitab Läänel paremat nõu otsida / Mohammad Hamdad ; interv. Kaarel Kaas

Index Scriptorium Estoniae

Hamdad, Mohammad

2006-01-01

Norra Islaminõukogu esimees Mohammad Hamdan vastab intervjuus prohvet Muhamedi karikatuuri skandaali, lääne-islami suhteid ning Norras elavate moslemite probleeme puudatavatele küsimustele. Lisa: Pilditüli

War without Violence: Leveraging the Arab Spring to Win the War on Terrorism

Directory of Open Access Journals (Sweden)

Pat Proctor

2012-01-01

Full Text Available After a decade of war, the United States has failed to eradicate the threat of salafist jihadism. No matter how hard it tries, the United States cannot kill its way to victory in the war on terrorism. Sweeping changes across the Middle East—dubbed the "Arab Spring" by the media—have presented the West with a unique opportunity to pursue an alternative approach. Rather than engaging in war (politics through violence, the United States should engage in mass politics (war without violence to compel the Arab world to reject the salafist jihadism idea. This article proposes a strategy calibrated to defeat international terrorism without unnecessarily antagonizing non-jihadist salafists and political salafists who enjoy broad-based support in the Arab world. The article goes on to identify key political figures already espousing elements of this counternarrative, and it describes the methods the United States should use to empower these and other anti–salafist jihadism activists.

Vägivallalaine uputas Palestiina ühisvalitsuse

Index Scriptorium Estoniae

2007-01-01

Radikaalne islami vastupanuliikumise Hamas ja palestiinlaste mõõdukamat osa esindava Fatah'i võitlejad pidasid Gaza linnaosades veriseid lahingud. Autonoomia presidendi Mahmoud Abbasi ja Iisraeli peaministri Ehud Olmerti hukkamõistvast suhtumisest

Meie universaalne tsivilisatsioon : [New Yorgis Manhattani Instituudis peetud loeng] / V. S. Naipaul ; tõlk. Triinu Pakk

Index Scriptorium Estoniae

Naipaul, V. S., 1932-

2003-01-01

Islami maailma negatiivselt suhtuva India päritolu Trinidadi kirjaniku maailmavaade. Ka enda kujunemisest kirjanikuks. Tõlke allikas: The New York Review of Books. 31.01.1991. Orig.: V. S. Naipaul, Our Universal Civilization

Identification and Characterization of the UL37 Protein of Herpes Simplex Virus Type 1 and Demonstration that it Interacts with ICP8, the Major DNA Binding Protein of Herpes Simplex Virus

Science.gov (United States)

1992-10-20

R . 1974 . Recovery of herpes simplex virus from human sacral gangl ions. N. Engl. J. Med. 291 :828-830. Baringer, J.R . 1975. Herpes simplex virus...AII’I fORCE MEDICAL C(NTEIt Title of Dissertation : "Ideatification and Characterization of the UL37 Protein of Herpes Simplex Virus Type 1 and...Demonstration that It Interacts with reps. the Major DNA Binding Protein of Herpes Simplex Virus" Name of Candidate: Lisa Shelton Doctor of

Usama bin Ladin’s Father Sheikh: Yunus Khalis and the Return of al-Qaida’s Leadership to Afghanistan

Science.gov (United States)

2013-05-14

development was  initially called Najm al‐Jihad  in  reference  to  its proximity  to  the  tomb   of  the  famed  Mullah  of  Hadda,  Najm  al‐Din...al‐Zawahiri: The  former head of  Egyptian   Islamic  Jihad  and  a key  al‐Qa`ida  member  and  propagandist,  al‐Zawahiri  has  served  as  the

Identiteet ja migratsioon / Francis Fukuyama

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Fukuyama, Francis

2007-01-01

Autor peab islamiäärmuslust immigrantide identiteedikriisi ilminguks ning arutleb identiteedipoliitika olemuse ja tuleviku üle Euroopa ja Ameerika postmodernses multikultuurilises ühiskonnas. Vt. samas: Jeffrey Goldstein: Euroopa ja USA - konkurendid või partnerid

Meediaterrorist Chris Morris / Margit Tõnson

Index Scriptorium Estoniae

Tõnson, Margit, 1978-

2010-01-01

Briti raadio- ja telesatiirik Christopher Morris ja tema (tele)tegemised seoses kinos Sõprus linastuva islamiäärmuslastest kõneleva komöödiafilmiga "Neli lõvi" (Suurbritannia 2010). Lisaks M. T. "Napid detailid eraelust"

Londoni terror sundis inglasi heitma pilgu endasse / Arko Olesk

Index Scriptorium Estoniae

Olesk, Arko, 1981-

2006-01-01

Aasta pärast Londonis toimunud enesetaputerroristide rünnakut, tunnevad Suurbritannias elavad moslemikogukonnad end valitsuse poolt hüljatuna ning on asunud üha enam toetama islamiäärmuslust. Kaart: Aastatagune terroripäev

A return to the Qur’ānic paradigm of development and integrated knowledge: The Ulū al-Albāb model

Directory of Open Access Journals (Sweden)

Mohd. Kamal Hassan

2010-12-01

Full Text Available The paper highlights that the secular and modernistic paradigm of development that lacks spiritual and ethical moorings is partly responsible for the 2009 global economic and financial crisis. Muslim policy-makers, intellectuals and scholars are duty-bound to promote the Tawḥīdic paradigm of holistic development and holistic knowledge. Closely related to the paradigm of development is the issue of the epistemology of autonomous human reason which denies the importance and validity of Divine revelation as a higher source of knowledge and wisdom. The Qur’ān projects the model of the Ulū al-Albāb, “people of sound reason” as intellectuals and scholars par excellence who combine the understanding of the Book of Nature with the Book of Revelation, and integrate human reason with Divine revelation. The paper ends by suggesting that Muslim countries develop institutions of learning or systems of education which integrates worldly knowledge with religious knowledge in a harmonious and symbiotic manner.

RELIGIOUS IDEOLOGY, OBJECTIVES, AND STRATEGY OF THE “CAUCASUS EMIRATE”

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Хубяр Фейзи оглы Агаев

2013-11-01

Full Text Available This paper analyzes the penetration of the Jihad religious ideology into the Northern Caucasus and the factors that have caused radicalization of Chechen/Caucasus militants. The review of mutual penetration of the global Jihad movement of religious extremism and terrorism in the Northern Caucasus is presented; the major religious extremism and terrorism masterminds and figures in theNorthern Caucasusare characterized. The main attention is paid to the activity of Islamic organization “Caucasus Emirate” in the Russian NorthernCaucasusand its serious effects on the region.Since the overwhelming majority of foreign researchers try to avoid mentioning the role of the global jihadist movement in the region, as well as the appeal of Jihadism for a significant number of young people or the effect of these factors on the ideology, objectives, strategy, and tactics of the “Caucasus Emirate, this paper focuses on the religious ideology, objectives, strategy, tactics, and the potential of the “Caucasus Emirate” in using violence on the territory of Russia.DOI: http://dx.doi.org/10.12731/2218-7405-2013-9-48

The Effectiveness of Model Learning CUPs: Impact on The Higher Order Thinking Skill Students at Madrasah Aliyah Mathla'ul Anwar Gisting Lampung

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Antomi Saregar

2016-10-01

Penelitian ini bertujuan untuk mengetahui efektivitas model pembelajaran CUPs (Conceptual Understanding Procedures terhadap kemampuan berpikir tingkat tinggi peserta didik kelas X IPA MA Mathla’ul Anwar Gisting. Metode penelitian yang digunakan adalah kuasi eksperimen dengan desain non equivalent control group. Populasi dalam penelitian ini berjumlah 52 peserta didik, dengan sampel X IPA 1 sebagai kelas eksperimen dan X IPA 2 sebagai kelas kontrol. Uji independent sample t-test digunakan untuk mengetahui perbedaan kemampuan berpikir tingkat tinggi peserta didik menggunakan model CUPs dengan model pembelajaran langsung. Hasil analisis menyatakan bahwa terdapat perbedaan rata-rata kemampuan berpikir tingkat tinggi peserta didik antara menggunakan model CUPs dengan model pembelajaran langsung. efektivitas penggunaan model CUPs lebih baik dalam meningkatkan kemampuan berpikir tingkat tinggi peserta didik, dapat diketahui dari nilai effect size yang diperoleh sebesar 0,3 termasuk dalam kategori sedang. Kata kunci: conceptual understanding procedures, HOTS, kemampuan berpikir tingkat tinggi, model CUPs

Saddam poodi muslimite mõnitamiseks / Ravil Khair Al-Din

Index Scriptorium Estoniae

Al-Din, Ravil Khair

2007-01-01

Autor avaldab arvamust, et Saddam Husseini kohtuotsuse eesmärk ei olnud mitte karistada kurjategijat, vaid näidata radikaalsete shiiitide võimu kogu islami kogukonna üle, Saddami hukkamisega rikuti usupüha tahtlikult, et provotseerida muslimeid

Pakistanis käib võitlus islamiriigi nimel / Karin Volmer

Index Scriptorium Estoniae

Volmer, Karin

2007-01-01

Pakistani pealinna Islamabadi Punase mošee ümber kestva, vähemalt 16 ohvrit nõudnud vastasseisu taga on islamiäärmuslaste soov kangutada ametist Ameerika-meelne president Pervez Musharraf. Vt. samas: Sündmused; Pakistan: kaart

Itaalia kohus mõistis 23 CIA agenti vangi islamisti röövi eest / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2009-01-01

Itaalia kohtu süüdimõistvast otsusest USA Luure Keskagentuuri (CIA) töötajate kohta islami äärmuslase Abu Omari ebaseadusliku vahistamise kohtuasjas, mis on esimene kohtuprotsess maailmas CIA töömeetodite üle

Radikaalsed palestiinlased tõid Liibanoni taas kodusõja äärele / Arko Olesk

Index Scriptorium Estoniae

Olesk, Arko, 1981-

2007-01-01

Lahingutest äärmusliku palestiinlaste rühmituse Fatah al-Islami ja Liibanoni armee vahel põgenikelaagris Tripoli linna lähedal Liibanoni põhjaosas. Kaart: Lahing põgenikelaagris. Vt. samas: Iisrael võttis sihikule Hamasi kõrgeimad juhid

To be or not to be Violent

DEFF Research Database (Denmark)

Sen, Somdeep

2012-01-01

June 19, 2012: the Palestinian skies lit up again with an exchange of rockets and air strikes between Israel and Hamas in Gaza, breaking the uneasy calm that had prevailed since March when Islamic Jihad had engaged in hostilities with Israel following the assassination of Zuhir al-Qaisi, the Secr......June 19, 2012: the Palestinian skies lit up again with an exchange of rockets and air strikes between Israel and Hamas in Gaza, breaking the uneasy calm that had prevailed since March when Islamic Jihad had engaged in hostilities with Israel following the assassination of Zuhir al...

Experimental and theoretical investigation of benzyl-N ...

Indian Academy of Sciences (India)

Experimental and theoretical investigation of benzyl-N-pyrrolylketene, one- step procedure for preparing of new β-lactams by [2+2] cycloaddition reaction. MASOUMEH BEHZADI, KAZEM SAIDI. ∗. , MOHAMMAD REZA ISLAMI and. HOJATOLLAH KHABAZZADEH. Department of Chemistry, Shahid Bahonar University of ...

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences; Volume 128; Issue 1. Experimental and theoretical investigation of benzyl--pyrrolylketene, one- step procedure for preparing of new -lactams by [2+2] cycloaddition reaction. Masoumeh Behzadi Kazem Saidi Mohammad Reza Islami Hojatollah Khabazzadeh. Regular ...

Etika Bisnis Islami Dalam Periklanan

OpenAIRE

Rahmaniah, Amelia

2009-01-01

As a bridge between producers and consumers, advertisement has a very strategic position from business point of view, since it can present complete and accurate information to the consumer about the product or service. Therefore, the advertisement should be paid attention seriously in Islamic business ethics. Advertisement that does not use ethics will damage the corporate image; and gradually the company may be unseen by the consumer. On the other hand, doe consumer may also have bad conseq...

ARSITEKTUR ISLAM ATAU ARSITEKTUR ISLAMI?

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Sativa Sativa

2011-01-01

  ABSTRACT. It has been regarded, there are so many discussion and study of Islamic architecture, particularly among academics and practitioners. Most of the discussion focuses on aspects of form, style, historical relics and other things that are considered physical is part of the culture of Muslims. Meanwhile, some people feel that the real Islam is not enough just realized with the physical aspect only. Currently, growing discourse about Islamic architecture which tends to emphasize Islamic values rather than physical typology of product architecture. In this matter, the author referred to it as Islamic Architecture. This paper is aimed to discover how extend to which the differences between two thinking about Islam Architecture and Islamic Architecture, and to find out the aspects which influence in Islamic Architecture product planning, through the study of various sources of the Qur'an and hadith, books, journals, and several articles, in addition to analysis of the author's own thoughts. From those studies it was found that a discussion of Islam architecture is very different from Islamic architecture. Islam architecture emphasizes the physical aspects of the built environment, while Islamic architecture is more advanced on Islamic values which root on Al Quran and hadith or sunnah of the Prophet. Aspects of Islamic architecture that need to be developed is efficiency, egalitarian, privacy and genius loci.   Keywords : Islam Architecture, Islamic Architecture, Islamic values

New physics effects in charm meson decays involving c → ul{sup +}l{sup -}(l{sub i}{sup -+}l{sub j}{sup ±}) transitions

Energy Technology Data Exchange (ETDEWEB)

Sahoo, Suchismita; Mohanta, Rukmani [University of Hyderabad, School of Physics, Hyderabad (India)

2017-05-15

We study the effect of the scalar leptoquark and Z{sup '} boson on the rare decays of the D mesons involving flavour changing transitions c → ul{sup +}l{sup -}(l{sub i}{sup -+}l{sub j}{sup ±}). We constrain the new physics parameter space using the branching ratio of the rare decay mode D{sup 0} → μ{sup +}μ{sup -} and the D{sup 0} - anti D{sup 0} oscillation data. We compute the branching ratios, forward-backward asymmetry parameters and flat terms in D{sup +(0)} → π{sup +(0)} μ{sup +}μ{sup -} processes using the constrained parameters. The branching ratios of the lepton flavour violating D meson decays, such as D{sup 0} → μe, τe and D{sup +(0)} → π{sup +(0)} μ{sup -}e{sup +} are also investigated. (orig.)

Islamifilosoof : Euroopat ähvardab "kokkupõrge tsivilisatsiooni sees" / Ahto Lobjakas

Index Scriptorium Estoniae

Lobjakas, Ahto, 1970-

2006-01-01

Tariq Ramadani esinemisest Brüsselis islamiteemalisel konverentsil, mille korraldasid Euroopa Parlamendi rohelised. T. Ramadan on seisukohal, et nähes muslimistes esmalt islamiusulisi ja alles siis kodanikke, riskib Euroopa tsivilisatsioonisisese kokkupõrke võimalusega. Lisa: Oponent näeb islamis takistust

Acciones de grupos terroristas de Próximo Oriente en España, 1975-1985

Directory of Open Access Journals (Sweden)

Domingo Jiménez Martín

2005-01-01

Full Text Available El objetivo de este informe es analizar las actividades de organizaciones terroristas de Próximo Oriente en España desde 1975 a 1985. Hoy la Jihad Global supone un nuevo capítulo en la historia del terrorismo. Los ataques terroristas a EE.UU., Reino Unido o España representan golpes contra su «enemigo lejano». Sin embargo, mucho tiempo antes de los atentados del 11-S, el terrorismo internacional había sido considerado como una de las amenazas más importantes a la seguridad. Se estudia el ataque terrorista contra el restaurante El Descanso (abril, 1985, reivindicado por la Jihad islámica. Aquel atentado, cerca de la Base Aérea de Torrejón (Madrid, fue un aumento importante en la escalada de violencia. El artículo temiina con el fin de aquellas actividades.The objective of this repon is to analyse the activities of Middie East terrorist organizations in Spain from 1975 to 1985. Today, the Global Jihad is a new chapter in the history of terrorism. Terrorist attacks upon USA, United Kingdom and Spain represent hits against their «far enemy». However, long before the 9-11 attacks, International terrorism had been considered as one of the most important threats to the security. The terrorist attack against El Descanso restaurant (April, 1985 is discussed. That bomb attack, near a US Air Forcé Base in Torrejón (Madrid, was an important raise in violence escalation (responsibility was claimed by Islamic Jihad. The article concludes with the end of those activities.

Islam vajab reformatsiooni / Salman Rushdie ; tõlk. Külli-Riin Tigasson

Index Scriptorium Estoniae

Rushdie, Salman

2005-01-01

"Saatanlike värsside" autori arvates on vaja reformiliikumist, mis tooks islami põhialused moodsasse aega. Sellise liikumise loomiseks ja käigushoidmiseks on vaja uut hariduslikku tõuget. Autor ütleb, et kõiki, ka pühasid ideid tuleb kohandada vastavalt muutunud reaalsusele

Karikatuurid vallandasid kultuuride kokkupõrke / Dan Bilefsky ; tõlk. Heiki Suurkask

Index Scriptorium Estoniae

Bilefsky, Dan

2006-01-01

Autori sõnul on Taani kujunenud väheusutavaks tulipunktiks kultuuridesõjas islami ja lääne vahel. Taani muslimikogukonna väitel väljendavad karikatuurid võimenduvat immigrantidevaenulikku õhkkonda. Üha enam noori Taani muslimeid liitub radikaalse rühmitusega Hizb ut-Tahrir

Milleks meile Afganistan? / Kalev Vilgats

Index Scriptorium Estoniae

Vilgats, Kalev

2007-01-01

Afganistani sõdade ajaloost ja riigi allakäigust alates 1973. aastast, kui Daud Khan korraldas riigipöörde ja kuningas pages riigist, Nõukogude okupatsioonist 1979-1989. Afganistanis toimuvatest islami terroristide koolitustest, Talibani võimust, narko- ja relvakaubandusest, Eesti kaitseväelaste hukkumisest Afganistanis. Kaart

An Overview of «Umdet ul-Ahbar» by Abdulgaffar Qirimi »

Directory of Open Access Journals (Sweden)

I.М. Mirgaleev

2014-07-01

Full Text Available The article reviews the manuscript book of Abdulgaffar Qirimi by the name of «Umdet ul-Ahbar» («The Support of Communications». This work is written in Ottoman language according to the tradition of Ottoman historical writings. Authors of the article briefly recount Abdulgaffar Qirimi’s information contained in his work and dedicated to Genghis Khan, the Golden Horde, and the Crimean Khanate. Recently in Kazan have been published the facsimile and transcription of this work. Therefore, the authors decided to introduce into scholarly circulation the Russian summary of this work (the work being translated into Russian. Using a continuous method, the authors have made an overview of the main political events mentioned in the book. This information will be useful for the specialists studying the history of the Golden Horde and Tatar khanates. The importance of this source is beyond any doubt since Abdulgaffar Qirimi reports many original details and, especially for the 18th century, his information is authentic and based on personal observations. The manuscript book consists of several parts. It contains information about world history, the history of the prophets, the history of the Seljuks and Ottomans. The main part of the work is devoted to the Golden Horde (starting from Genghis Khan and his descendants, Crimean Khanate, Girayids and murzas. Abdulgaffar Qirimi sought to write a history of the descendants of Jochi khan. He used in his book more than 20 historical works. Abdulgaffar Qirimi reports the names of these works and indicates where he got this or that information. At the same time, he had access to the archives of the Crimean Khanate and used his family legends as well as popular traditions. Plenty of space in his work occupy his own observations as of a participant in military campaigns and court life. Although Abdulgaffar Qirimi makes some mistakes, however his work contains a complete history of the Golden Horde. His

PEMBELAHAN IDEOLOGI, KONTESTASI PEMILU, DAN PERSEPSI ANCAMAN KEAMANAN NASIONAL: SPEKTRUM POLITIK INDONESIA PASCA 2014?

Directory of Open Access Journals (Sweden)

Ari Ganjar Herdiansah

2017-06-01

Full Text Available Keamanan geopolitik dan sentimen keagamaan menjadi isu politik yang mencuat di Indonesia pasca 2014. Semenjak Joko Widodo menjadi presiden, isu kedekatannya dengan China seringkali dikemas sebagai citra yang negatif terhadap pemerintahannya. Di sisi lain, menguatnya pengaruh China di Asia Tenggara turut mempengaruhi perubahan peta ekonomi politik di Indonesia. Investasi dan dana pinjaman dari China meningkat tajam yang diiringi kompensasi proyek infrastruktur yang diberikan kepada China. Akan tetapi, memori kolektif masyarakat Indonesia terkait identiknya China dan komunisme menyulut kekhawatiran bangkitnya Partai Komunis Indonesia (PKI di Indonesia. Secara kebetulan, persaingan Gubernur Jakarta 2017 yang diikuti oleh Basuki Tjahaya Purnama, petahana kuat berlatar etnik China yang diusung oleh partai pemerintah (PDIP, menjadi momentum yang membangkitkan komponen Islamis yang sudah menaruh curiga terhadap kebangkitan PKI. Artikel ini menelaah bagaimana faktor menguatnya pengaruh China dan kedigdayaan politik PDIP membentuk pusaran konflik aliran antara nasionalis kiri dengan kanan Islamis yang membawa kerawanan keamanan di Indonesia pada level lebih tinggi.

Sõnavabaduse dogma Hollandi moodi / Kaspar Näf

Index Scriptorium Estoniae

Näf, Kaspar

2008-01-01

Šveitsi ajaloolane ja ajakirjanik leiab Hollandi parlamendisaadiku Geert Wildersi islami-vastase filmi ja ENPA endise presidendi Rene van der Lindeni arvamusavaldustega seoses, et kui sõnavabadus ja arvamuse väljendamine on eesmärk iseenesest, siis on see eriti neil juhtudel absurdne, kui seab teisi inimesi ohtu

Protestibiennaal kunsti suukorvistamise vastu / Margit Tõnson

Index Scriptorium Estoniae

Tõnson, Margit, 1978-

2006-01-01

Tšetšeenia toetuseks organiseeritud rahvusvahelisest rändnäitusest "Emergency Biennale" Tallinna Kunstihoones, kuraator Evelyne Jouanno. Kaasaegse Kunsti Eesti Keskuse korraldatud ettekandepäevast "Kunstniku moraalsed valikud liberaalse demokraatia ja islami kokkupõrgetes", kus esinevad Margit Sutrop, Johannes Saar, Marek Järvik, Ene-Liis Semper, Eero Epner

Boko Haram in northern Nigeria: a Maududian legacy | Dikki ...

African Journals Online (AJOL)

The paper establishes this by showing that “Ikhwan al-Muslimun (Muslim Brotherhood) of Egypt, the Jama'at-i-Islami of Pakistan, the Wahabbi views in Saudi Arabia and Islamic revolution of Iran are all indirect propagators of Maududian ideology. This fundamentalist ideological influence in northern Nigeria began with ...

Tokat’ın 17. Yüzyıl Âlim Şairlerinden İshak Bin Hasan Tokatî ve Nazmu’l-Ulum Adlı Mesnevîsi Poetry in Rhymed Couplets of Tokatlı İshâk Efendi Nazmu'l-Ulûm

Directory of Open Access Journals (Sweden)

Bayram ÖZFIRAT

2013-03-01

Full Text Available As manuscript works, which constitute some indispensabletreasure with respect to history of our literature, come back into light,our knowledge on religious literary genres, as well as other, no doubtincreases. Such works added to literature thanks to efforts byresearchers give us the opportunity of close acquaintance with religiousworks that are considered as the most significant and the most prolificproducts of Divan Poetry, and of more accurate interpretationsregarding the genre of such works. Apart from works such as aqâid, fiqhand catechism (ilm-i hal in verse, siyer (life of Muhammad in verse,exegeses (tafsir and hadithes in verse that are generally written inpoetic structure for these disciplines, there are also some poetic piecesabout a subdivision or important question of abovementioned Islamicsciences. Faraiz, Hegira of Muhammad, miraj-name, rules of hajj,miracles of Prophet, all in verse, can be mentioned among suchexamples. In the wake of our researches, we found out that thesecatechisms in verse constitute a notable part of our religious literature.Tokatlı İshâk Efendi was an important poet and writer who lived in 17th century. Biographic sources dores not mention him alot. The poetryin rhymed couplets, Nazmu’l-Ulûm, which we are working on shows ushow important poet he is. At his Nazmu’l-Ulûm İshâk Efendi givesinformation about different sciences and wants them to learn. Becauseof these properties Nazmu’l-Ulûm is a written verse advice. Nazmu’l-Ulûm have got strong rhymes. That is possible to say poetry in rhymedcouplets have fascinating expressions rather than bare tellings. Somany telling arts and describtions were given place in that book. Tokatlı İshâk Efendi on yedinci yüzyılda yaşamış önemli bir şâir ve yazardır. Biyografik kaynaklar kendisinden fazla bahsetmez. Ama eserlerinden yola çıktığımızda Tokatlı İshâk Efendi’nin yetenekli bir şâir olduğunu rahatlıkla söyleyebiliriz. �

A Hundred Osamas: Islamist Threats and the Future of Counterinsurgency

National Research Council Canada - National Science Library

Zuhur, Sherifa

2005-01-01

.... The author of this monograph, Dr. Sherifa Zuhur, examines the intensity and diversification of extremist efforts and outlines their "new jihad" and its relationship to the regeneration of extremist leadership...

Asuransi Islami Dan Pembangunan Ekonomi Umat

Directory of Open Access Journals (Sweden)

Muhammad Iswadi

2015-01-01

Full Text Available This paper discusses the debate jurists of insurance, there are some that allow and prohibit, with various arguments. At the next turn spawned Takaful is a concrete solution to address the issue of people who really need insurance. Islamic insurance does have differences in terms of both form and nature with conventional insurance. There are two types of takaful insurance products, namely family takaful and general takaful. This insurance can also increase or help the economic development of the people, with a range of multiplier effect caused

The Pattern of Soviet Conduct in the Third World. Review and Preview. Part 4

Science.gov (United States)

1983-03-07

shoe is now on the olner foot. H recent study by Jan Navous and Michael Marrese arrives at tne conclusion that, in 1980 dollars, the U.S. suosicizec...particularly Abdulhafiz Abdurabbuh for his article in Akhbar al- Alam-i Islami, "Communist Terror against Islam". -- MSE, 3/1977, pp. 18-20, "A biased

Dakwah Islam Dan Radikalisme Agama

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M. Bisri Djalil

2016-03-01

Full Text Available A thing closely related to bustle the life of the religious contemporary is radicalism phenomenon. The question is: Does Islam teach radicalism? The answer of this question always problematic. It is caused by every religion (either Islam or the other viewed as an acceptance that granted as a divinity instrument that teaches everything in goodness. Islam is a religion that provide of security, comfort, calmness as more strengthening for all its adherents. In Indonesia, radical Islamic groups often associated with groups like company of Salafy (Bandung, Islamic Youth Front (FPIS, Islamic Defender Front (FPI, Jihad’s Troop of Ahlus Sunnah Wal Jama’ah, The Tribunal of Indonesian Mujahidin, Hizbut Tahrir of Indonesia. The movement of Islam in Indonesia cannot be viewed as a monolithic movement or uniform in the same of political interest. That moment, political global movement has variation in the perspective, motive, strategy and action. One thing that same as the source of radicalism is the definition of the concept of jihad. Eventually, the construction of jihad affects the Islamic propaganda (dakwah ideology and movement. Ideally the realization of the concept of Jihad is not led to radicalism. If indeed reflect to the era of the Prophet Muhammad (pbuh, then it must be conceived with the conditions encountered at that time.

“Jihad Cool/Jihad Chic”: The Roles of the Internet and Imagined Relations in the Self-Radicalization of Colleen LaRose (Jihad Jane

Directory of Open Access Journals (Sweden)

Caroline Joan S. Picart

2015-04-01

Full Text Available The internet provides the means through which a “self-activating terrorist” may first self-radicalize through some imaginary or sympathetic connection with an organized terrorist network. Additionally, the internet allows such a self-activating terrorist to move into the stage of radical violent action. The internet serves both functions by providing the lone wolf with not only a rhetorical medium for self-justification and communication through the use of “monster talk” and its converse, the rhetoric about the “good citizen,” but it is also a source for relatively inexpensive and more unpredictable technologies of mass destruction. Crucial to this analysis is the distinction between radicalization of thought and radicalization of action, as a theoretical rhetoric of radicalization does not automatically convert into a rhetoric of radical action unless there are catalysts at work. The internet, as well as imagined relations cemented by the rhetorics of “jihadi cool” or “jihadi chic,” function as these crucial catalysts, galvanizing monster talk into monstrous action. The article focuses specifically on the case of self-activating terrorist Colleen LaRose to analyze how different factors—mental, psychological, social, and economic—interact with imaginative elements, such as surrogate father-mentor-lover relations for LaRose, and contribute to the formation of a self-activating terrorist, and what ultimately motivates and galvanizes her to move from a rhetoric of radical talk to a rhetoric of radical action, using Silber and Bhatt’s model of radicalization as an initial heuristic. In the case of Colleen LaRose, the romance of “jihadi chic” or “jihadi cool” (the converse of the rhetoric of the monstrous “infidel” or “lone wolf terrorist” was an essential factor to her self-radicalization. It is this imagined status of “jihadi chic” or “jihadi cool” (that nevertheless must somehow have a look of “reality” or “authenticity” and command a response from its audience that continues to be a crucial component of the success of recruitment strategies of radical jihadi groups, such as ISIS.

Otto Jastrow: islam ja demokraatia ei sobi kokku / intervjueerinud Villu Zirnask

Index Scriptorium Estoniae

Jastrow, Otto

2011-01-01

TLÜ Eesti humanitaarinstituudi araabia keele professor on seisukohal, et kui Egiptuse president Hosni Mubarak langeb, võib Egiptuses järgneda kaos ja radikaalse Muslimi Vennaskonna võimule pääsemine. Ta loodab, et Egiptuses võtab lähipäevil võimu sõjavägi. Islami muutumisest tagurlikumaks, islamist ja vägivallast

Inimõiguste kaitseks Tšetšeenias / Andres Herkel

Index Scriptorium Estoniae

Herkel, Andres, 1962-

2008-01-01

Moskva Carnegie Keskuse teaduri Aleksei Malashenko sõnul muutuvad Kaukaasia ühiskonnad traditsioonilisemaks, taaselustub veritasu ja kasvab islamiäärmusluse mõju. Tšetšeenia juhist Ramzan Kadõrovist, kelle autoriteediks on Venemaa president Vladimir Putin, ning iseseisvuslaste juhist Doku Umarovist. Tšetšeenia küsimuse poliitilise tõstatamise raskustest ja inimõiguste probleemidest

AN VIEW TO RELATION OF MOTHER-SON IN THE CONTEXT OF AN HONOR KILLING IN ELİF ŞAFAK’S NOVEL İSKENDER ELİF ŞAFAK’IN İSKENDER ROMANINDA BİR TÖRE CİNAYETİ BAĞLAMINDA ANNE-OĞUL İLİŞKİSİNE BAKIŞ

Directory of Open Access Journals (Sweden)

Fethi DEMİR

2012-01-01

Full Text Available Elif Şafak narrates a tragic relation of mother-son in the context of an honor killing, in her last novel İskender. Şafak, who tells this honor killing with the point of view woman, approaches with a different point to oedipus comlex which has been written in the male dominated author world as a relation of father-son and Şafak puts forward mother figure that has been remained background in this psychoanalytic triangle. This prominence, extends the limits of oedipus theme, provides to evaluate this theme with various and wealthy connotations. On the other hand, as she also discusses “custom/honor crimes”, one of the important social problems, in a feminist sensitivity, she extends this mother-son relation as part of Turkish novel’s ancient themes like convention-modernity, mysticism, and East-West. Elif Şafak, son romanı İskender’de bir töre cinayeti bağlamında trajik bir anne-oğul ilişkisini anlatır. Töre cinayetini kadın bakış açısından yansıtan Şafak, yıllarca erkek egemen yazar dünyasında baba-oğul ilişkisi biçiminde işlenen Oedipus kompleksine farklı bir noktadan yaklaşır ve bu psikanalitik üçgende geri planda bırakılan anne figürünü öne çıkarır. Bu önceleme, Oedipus temasının sınırlarını genişletir, farklı ve zengin çağrışımlarla değerlendirilmesine olanak sağlar. Öte taraftan Türkiye’nin önemli toplumsal dertlerinden “töre/namus cinayetlerine” feminist bir duyarlılıkla bakması da bu anne-oğul ilişkisinin boyutlarını genişletir.

MARKETING RESEARCH REGARDING TOURISM BUSINESS READINESS FOR ECO-LABEL ACHIEVEMENT (CASE STUDY: NATURA 2000 CRIŞUL REPEDE GORGE-PĂDUREA CRAIULUI PASS SITE, ROMANIA

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Olimpia Iuliana BAN

2015-12-01

Full Text Available Sustainable development is an approach that aims to preserve the environment and the culture of communities hosting tourists and at the same time to meet the needs of tourists and to maintain the growth of tourism industry. These objectives are more and more related to eco-labelling, which provides the certification based on a series of benchmarks developed and verified by a third party. The labelling of an organization as an ecotourism organization requires the compliance with certain criteria as those required by the European Ecotourism Labelling Standard. Natura 2000 Crişul Repede Gorge– Pădurea Craiului Pass site will have to prove that it is in compliance with the prerequisites to become an ecotourism destination. The objectives of this paper are: to identify the prerequisites that a destination must comply with in order to be labelled an ecotourism destination, focusing on the prerequisites related to the existence and behaviour of tourist reception structures; to identify the extent to which tour operators are open  and willing to support the labelling of the destination where they operate as being ecotourism.  

Psühholoogiline pingpong / Anari Koppel

Index Scriptorium Estoniae

Koppel, Anari

2007-01-01

PÖFFi filme - islamiäärmuslase poolt mõrvatud hollandi režissööri Theo van Goghi mälestuseks tema 2003.a. linastunud filmi põhjal loodud mängufilm "Intervjuu" ("Interview") : režissöör ja peaosatäitja Steve Buscemi : Ameerika Ühendriigid - Holland 2007. Lisatud selgitav tekst Theo van Goghi kohta

Ottomani pärijad Euroopasse? / Immanuel Wallerstein

Index Scriptorium Estoniae

Wallerstein, Immanuel

2004-01-01

Türgi ajaloost, läänestumisest ning seostest Euroopaga. Autori hinnangul saab otsuse langetamisel Türgi liitumise kohta Euroopa Liiduga määravaks, kas Euroopa näeb oma tulevikku sekulaarse või kristlikuna; Türgi väljajätmine võib põhjustada aga tasakaalunihke Lähis-Idas ja suurendada Türgis radikaalse islami mõju

THE IMPACT OF UNIVERSITY EDUCATION ON THE MORAL DEVELOPMENT OF ACCOUNTING STUDENTS: A CASE STUDY

OpenAIRE

Umaru Zubairu

2016-01-01

Two decades of financial scandals have seriously damaged the credibility of accountants as guardians of financial information. To repair this credibility, the Malaysian government released a blueprint that mandated Malaysian educational institutions to produce morally competent professionals. This study assessed the progress of Malaysian universities in meeting this important mandate by evaluating the moral development of accounting students enrolled at the International Islami...

Muhamed on Taani tulnud, et jääda / Arvo Alas

Index Scriptorium Estoniae

Alas, Arvo, 1943-2007

2006-01-01

Ilmunud ka: Postimees : na russkom jazõke 7. märts lk. 11. Taani poliitikud, majandusringkonnad, ühiskonnategelased ja ka vaimulikud otsivad väljapääsu pildiskandaali kriisist. Ühiskondlike vahenditega tahetakse Kopenhaagenis ja Arhusis mosheed rajada, ülikoolides kaalutakse võimalusi teoreetilise islami osakondade tekitamiseks ning Taani islamiusulised poliitikategelased on loonud uue ühingu Demokraatlikud Moslemid. Lisa: Pilapildisaaga

75 FR 9439 - FM Approvals: Application for Expansion of Recognition; Wyle Laboratories: Voluntary Modification...

Science.gov (United States)

2010-03-02

... superseded by UL 153. UL 268A Smoke Detectors for Duct Application UL 484 Room Air Conditioners UL 521 Heat... Transformers and Motor Transformer for Use in Audio-, Radio-, and Television-Type Appliances UL 1412 Fusing... Halon 1211 Recovery/Recharge Equipment UL 2111 Overheating Protection for Motors III. Temporary...

Terorisme sebagai Cabaran Ideologi Muslim Masa Kini: Satu Analisis dari Perspektif Falsafah

Directory of Open Access Journals (Sweden)

ZUL`AZMI YAAKOB

2015-06-01

Full Text Available Terrorism is currently becoming an ideological challenge for Muslims in contemporary world. The rise of terrorist groups such as the Islamic State (IS and others who claimed themselves as jihadist and propagates Islamic jihad similar to the idea of the medieval ‘Holy War’ not only target non-Muslims or kuffar, but also their Muslim brothers respectively. This act of terrorism raised dilemma among Muslim societies in general whether to support the extreme groups or to defy them as they portrayed themselves as representing the whole Muslims whereas in fact they only represent a group of disillusioned Muslims. This paper aims at analysing their ideological challenge from the philosophical point of view and Islamic ethics. Generally, this analysis emphasizes on the importance of Islamic ethics and law in order to achieve true understanding of jihad.

Waging and Fighting e Jihad

Science.gov (United States)

2012-12-01

terrorists would have roughly the same impact as techniques used by ordinary hackers, hactivists and cyber criminals .” 25 Ironically, the group that...beyond their capability. Increased collaboration with cyber criminals and recruiting better educated members moved their technological knowledge

Military Strategy of Global Jihad

National Research Council Canada - National Science Library

Zabel, Sarah E

2007-01-01

.... Global jihadis have spent more than 40 years refining their philosophy, gaining experience, building their organization, and developing plans to re-establish what they see as the only true Islamic state on earth...

Military Strategy of Global Jihad

National Research Council Canada - National Science Library

Zabel, Sarah E

2007-01-01

.... The 9/11 attacks set this plan in motion. In the years leading up to and following the 9/11 attacks, global jihadis have written copiously on their military strategy for creating an Islamic state...

Preface: The Oligotrophy to the UlTra-oligotrophy PACific Experiment (OUTPACE cruise, 18 February to 3 April 2015)

Science.gov (United States)

Moutin, Thierry; Michelangelo Doglioli, Andrea; de Verneil, Alain; Bonnet, Sophie

2017-07-01

The overall goal of OUTPACE (Oligotrophy to UlTra-oligotrophy PACific Experiment) was to obtain a successful representation of the interactions between planktonic organisms and the cycle of biogenic elements in the western tropical South Pacific Ocean across trophic and N2 fixation gradients. Within the context of climate change, it is necessary to better quantify the ability of the oligotrophic ocean to sequester carbon through biological processes. OUTPACE was organized around three main objectives, which were (1) to perform a zonal characterization of the biogeochemistry and biological diversity of the western tropical South Pacific during austral summer conditions, (2) to study the production and fate of organic matter (including carbon export) in three contrasting trophic regimes (increasing oligotrophy) with a particular emphasis on the role of dinitrogen fixation, and (3) to obtain a representation of the main biogeochemical fluxes and dynamics of the planktonic trophic network. The international OUTPACE cruise took place between 18 February and 3 April 2015 aboard the RV L'Atalante and involved 60 scientists (30 onboard). The west-east transect covered ˜ 4000 km from the western part of the Melanesian archipelago (New Caledonia) to the western boundary of the South Pacific gyre (French Polynesia). Following an adaptive strategy, the transect initially designed along the 19° S parallel was adapted along-route to incorporate information coming from satellite measurements of sea surface temperature, chlorophyll a concentration, currents, and diazotroph quantification. After providing a general context and describing previous work done in this area, this introductory paper elucidates the objectives of OUTPACE, the implementation plan of the cruise and water mass and climatological characteristics and concludes with a general overview of the other papers that will be published in this special issue.

Iran's Relations to the East: Nonproliferation and Regional Security in a Changing Southwest Asia

Energy Technology Data Exchange (ETDEWEB)

Tehsin, Muhammad [Quaid-I-Azam Univ., Islamabad (Pakistan)

2014-11-01

This study attempts to answer the following questions: would a successful JPOA result in nuclear nonproliferation and regional security in Southwest Asia; and could the Middle East and South Asia work together to contain the threat of Salafi jihadism?

An Overview of Selected Nigerian Northern and Southern Poets

African Journals Online (AJOL)

Tracie1

A modern African culture, whatever else it might be, must be a continuation of old African ... the Nigerian literature start from the legendary period known largely as the ... poetry record Jihad, slavery and foreign trade. The oral tradition, which ...

Inner tegument proteins of Herpes Simplex Virus are sufficient for intracellular capsid motility in neurons but not for axonal targeting

Science.gov (United States)

Müller, Oliver; Ivanova, Lyudmila; Bialy, Dagmara; Pohlmann, Anja; Binz, Anne; Hegemann, Maike; Viejo-Borbolla, Abel; Rosenhahn, Bodo; Bauerfeind, Rudolf; Sodeik, Beate

2017-01-01

Upon reactivation from latency and during lytic infections in neurons, alphaherpesviruses assemble cytosolic capsids, capsids associated with enveloping membranes, and transport vesicles harboring fully enveloped capsids. It is debated whether capsid envelopment of herpes simplex virus (HSV) is completed in the soma prior to axonal targeting or later, and whether the mechanisms are the same in neurons derived from embryos or from adult hosts. We used HSV mutants impaired in capsid envelopment to test whether the inner tegument proteins pUL36 or pUL37 necessary for microtubule-mediated capsid transport were sufficient for axonal capsid targeting in neurons derived from the dorsal root ganglia of adult mice. Such neurons were infected with HSV1-ΔUL20 whose capsids recruited pUL36 and pUL37, with HSV1-ΔUL37 whose capsids associate only with pUL36, or with HSV1-ΔUL36 that assembles capsids lacking both proteins. While capsids of HSV1-ΔUL20 were actively transported along microtubules in epithelial cells and in the somata of neurons, those of HSV1-ΔUL36 and -ΔUL37 could only diffuse in the cytoplasm. Employing a novel image analysis algorithm to quantify capsid targeting to axons, we show that only a few capsids of HSV1-ΔUL20 entered axons, while vesicles transporting gD utilized axonal transport efficiently and independently of pUL36, pUL37, or pUL20. Our data indicate that capsid motility in the somata of neurons mediated by pUL36 and pUL37 does not suffice for targeting capsids to axons, and suggest that capsid envelopment needs to be completed in the soma prior to targeting of herpes simplex virus to the axons, and to spreading from neurons to neighboring cells. PMID:29284065

MK-2206, an AKT Inhibitor, Promotes Caspase-Independent Cell Death and Inhibits Leiomyoma Growth

Science.gov (United States)

Sefton, Elizabeth C.; Qiang, Wenan; Serna, Vanida; Kurita, Takeshi; Wei, Jian-Jun; Chakravarti, Debabrata

2013-01-01

Uterine leiomyomas (ULs), benign tumors of the myometrium, are the number one indication for hysterectomies in the United States due to a lack of an effective alternative therapy. ULs show activation of the pro-survival AKT pathway compared with normal myometrium; however, substantial data directly linking AKT to UL cell survival are lacking. We hypothesized that AKT promotes UL cell survival and that it is a viable target for inhibiting UL growth. We used the investigational AKT inhibitor MK-2206, currently in phase II trials, on cultured primary human UL and myometrial cells, immortalized leiomyoma cells, and in leiomyoma grafts grown under the kidney capsule in mice. MK-2206 inhibited AKT and PRAS40 phosphorylation but did not regulate serum- and glucocorticoid-induced kinase and ERK1/2, demonstrating its specificity for AKT. MK-2206 reduced UL cell viability and decreased UL tumor volumes. UL cells exhibited disruption of mitochondrial structures and underwent cell death that was independent of caspases. Additionally, mammalian target of rapamycin and p70S6K phosphorylation were reduced, indicating that mammalian target of rapamycin complex 1 signaling was compromised by AKT inhibition in UL cells. MK-2206 also induced autophagy in UL cells. Pretreatment of primary UL cells with 3-methyladenine enhanced MK-2206-mediated UL cell death, whereas knockdown of ATG5 and/or ATG7 did not significantly influence UL cell viability in the presence of MK-2206. Our data provide molecular evidence for the involvement of AKT in UL cell survival and suggest that AKT inhibition by MK-2206 may be a viable option to consider for the treatment of ULs. PMID:24002033

ETIKA BISNIS ISLAMI DALAM PRAKTEK BISNIS RASULULLAH

Directory of Open Access Journals (Sweden)

Muhammad Saifullah

2011-06-01

Kajian sejarah mengenai perilaku dan etika bisnis Muhammad sebelum ditunjuk sebagai nabi merupakan kajian yang menarik, karena peri laku dan etika bisnis yang diterapkan oleh Muhammad didasarkan pada kajian ayat-ayat al-Qur’an. Setelah ditunjuk sebagai nabi (usia 40 tahun, kehidupan Nabi Muhammad lebih dibimbing oleh wahyu-wahyu al-Qur’an. Beberapa prinsip yang diterapkan oleh Muhammad adalah jujur, amanah, timbangan yang tepat, menghindari gharar, tidak menimbun barang, tidak melakukan al-ghalb dan tadlis di antara penjual dengan pembeli.

ETOS KERJA ISLAMI DALAM MEWUJUDKAN KESEJAHTERAAN SOSIAL

Directory of Open Access Journals (Sweden)

Mia Fitriah Elkarimah

2016-12-01

Full Text Available Indicators of human quality is a human who has a high work ethic, human quality means certainly have high motivation, always work and achievement. The quality of human resources is a central point of movers and managers from various types of other resources. The work ethic in Islam perspective is not enough to get the one purpose of welfare, but a manifestation of pious charity whose purpose is more comprehensive, Islam assess welfare  must be guided with other instruments such as charity, donation, and shadaqah. The fact, Muslim has not been fully implemented yet the instrument. For this reason will be explained relation work ethic and social welfare in Islam perspective as a mediator to contact among segments

Menjadi Manusia Kreatif: Sudut Pandang Psikologi Islami

OpenAIRE

Nashori, Fuad

2004-01-01

AbstractThis writing intended to reveal Islamic Psichology view to creativity. Islamic Psichology it selfmeans a study about human soul and behaviour based on Islamic world view. Islamic Psichology bas aview that religiousness gives impact to crativity. Fervent belief, diligent worship, charities and farventreligious experince are proved anable man to get creative idea that has bigher or more eternal truth level.Creativity certainly gives impact to the glory of  Islamic society.Keyword : Crea...

TEMBHANG MACAPAT DALAM TRADISI ISLAMI MASYARAKAT MADURA

Directory of Open Access Journals (Sweden)

Edi Susanto

2016-10-01

Full Text Available This article is about to describe Tembhang Macapat in the tradition of Madurese people, particularly in the village of Larangan Luar that is located in Larangan district of Pamekasan regency. It has been stated that Tembhang Macapat appears as cultural treasure that its existence needs to conserve. However it is as well claimed as out of dated culture since its noble and gallant values have been decreased. Hence structured and thoughtful attempts must be designed to promote Tembhang Macapat and the other traditional treasures in form of local content curriculum. Furthermore the department in charge, The Youth, Sport, and Cultural Affairs (Disporabud, must get optimally involved to look after and develop the local tradition by supporting any events of tradition development. As a result it could raise and fertilize the local tradition everlastingly or at least it is able to survive in the future time.

Iraan Suurbritannia vastu : kes paindus? / Francis Fukuyama

Index Scriptorium Estoniae

Fukuyama, Francis

2007-01-01

Ilmunud ka: Postimees : na russkom jazõke 17. apr. lk. 7. Iraani sisepoliitikast seoses 15 Briti mereväejalaväelase arreteerimise ja vabastamisega, Iraani probleemist Islami Revolutsioonilise Kaardiväe (IRGC või Pasradan) ja sellega liidusuhetes olevate institutsioonidega nagu Basj sõjaväeline rühmitus. Autori arvates tahtsid mõned Iraani rühmitused teravdada vastasseisu Suurbritannia ja USA-ga

Pre-Deployment Handbook: Afghanistan (post 2014)

Science.gov (United States)

2014-05-01

rainfalls. MAJOR CITIES Northern Plains 107 Mazar-e-Sharif (pop. 300,000+). Mazar-e-Sharif ( Tomb of the Chosen One) is named for its...League (Rabitat al-Alam al-Islami) and Egyptian -based Muslim Brotherhood (Jamaat al-Ikhwan al-Muslimin). TAXATION AND STATE-BUILDING...Shia practice of venerating saints and constructing tombs over prophet’s graves are seen as heretical ‘polytheistic’ innovations by Salafists. In

Jordaania plahvatuste juhtniidid viivad Iraaki / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2005-01-01

Jordaania plahvatuste uurimisel tuvastati enesetapurünnaku toimepanijad ning vahistati ühe enesetaputerroristi naine, kes rünnakus oli ellu jäänud. Jordaania kuningas Abdullah II kutsus üles koostööle terroristide vastu võitlemiseks. Samal ajal on al-Qaida juhid ja Iraagi terroristide liider al-Zarqawi omavahel tülis. Lisa: Iraagi terroristidel uus eeskuju; Briti kuninganna kuulutati islami vaenlaseks

Diagnosing the Boko Haram Conflict: Grievances, Motivations, and Institutional Resilience in Northeast Nigeria

Science.gov (United States)

2015-01-01

delinquency , and extreme economic inequality. The emergence of Boko Haram is a symptom of the maturation of historical extremist and rejectionist impulses...11  History of fundamentalism, rejectionist tendencies, and jihad ................................ 12... History of secessionist tendencies and challenges to national government authority

[Upper limb work-related musculoskeletal disorders (UL-WMSDs) in a large factory of the upholstered furniture industry: risk management].

Science.gov (United States)

Nicoletti, S; Castoro, V; Iacobellis, M; Loizzo, N; Monopoli, L

2008-01-01

The industrial production of upholstered furniture exposes workers to significant risk of occupational disorders due to ergonomics-related problems, such as repetitive strain and movements of the upper limb, manual load lifting, prolonged static postures. This paper describes the main measures taken by the biggest company in the "sofa sector" in southern Italy in order to solve such problems in the years 1996-2004. the classic instruments of ergonomics were used such as risk assessment, medical surveillance, training and information programmes, technological reorganization of the manufacturing process and of single working tasks. The accident rate (number of accidents per million working hours) which showed an increasing trend in the previous years, rose from a value of 31 in 1996 to 51 in the years 1999-2000 (with a percentage of accidents related to load lifting in the range 25-35%). At the same time the incidence rate of work-related upper limb musculoskeletal disorders (UL-WMSDs) in the population of workers (which had increased in the meantime from 2500 to 3500 employees) reached nearly 5% in 2001, with peaks of 8-9% in the work tasks with higher exposure. Accident rates progressively fell in the following three years until a value of 20 was reached in 2004 and 2005, while the mean incidence rate of WMSDs reached a value of nearly 1%. The data need to be compared with the trends in the other companies of the sector in the same period, with an average incidence rate of WMSDs around 2% and a generally increasing trend. Ergonomic interventions not only concur in the management and control of negative events for workers health but also in achieving advantages in terms of lower costs and greater productivity.

Iranian Religious and Political Influence in Persian Gulf Countries (Bahrain, Saudi Arabia and Kuwait

Directory of Open Access Journals (Sweden)

Юлия Игоревна Ильина

2016-12-01

Full Text Available This article is focuses on evolution of Iranian political influence in Persian Gulf countries. It examines theological and political aspects of such influence and its consequences for the region. The author analyses origins of the transnational Shia movements such as “Harakat ar-Risala” and “ad-Dawa” linked with traditional Shia institutions at Najaf and Kerbela, and its ambiguous relationships with post-revolution Iranian elite. In the same way, not all of Shias of Persian Gulf was “fascinated” by “Islamic revolution” in Iran and became admirers of R. Khomeini’s conception of “vilayat-e-faqih”. In addition, the author traces history of local political Shia movements, that are, in fact, more influential on domestic politics of Gulf countries that mythical “Iran’s hand”.

Genealogies of Islamic radicalism in post-Suharto Indonesia

NARCIS (Netherlands)

Bruinessen, M.M. van

2002-01-01

The emergence of violent Muslim vigilante groups employing a jihadist discourse and mobilizing followers for jihad in regions where there have been inter-religious conflicts, such as the Moluccas or the Poso district in Central Sulawesi, is one of the most conspicuous new phenomena

Containing Revolutionary Islam: Reassessing the Problem and the Approach

Science.gov (United States)

2017-03-01

1997), 152-155. Giap studied not only Mao, but Clausewitz, Napoleon, Sun Tzu , and T.E. Lawrence. While he amalgamated many of the ideas and concepts...Thoughts ........................................................................................................................... 52 Bibliography ...54 Bibliography Aaron, David. In Their Own Words: Voices of Jihad--compilation and Commentary. Santa Monica

Democratic Values and Support for Militant Politics: Evidence from a National Survey of Pakistan

Science.gov (United States)

2012-11-27

Swami, Praveen . 2007. India, Pakistan and the Secret Jihad: The Covert War in Kashmir 1947–2004. London: Routledge. Terror Free Tomorrow and the...Collapse in the International System, Second Edition. New Haven: Yale University Press. 12   Swami, Praveen . 2007. India, Pakistan and the

STRUCTURILE DE DEFLECTORI, FACTORI DE ÎMBUNĂTĂŢIRE AI HABITATULUI PISCICOL- STUDIU DE CAZ, RÂUL NICOLET (QUEBEC-CANADA

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Marius DULGHERU

2010-06-01

Full Text Available Deflection structures factors for improve the fish habitat. Case study nicolet river (Quebec-Canada. Există câţiva factori care joacă un rol important în definirea calităţii habitatului fizic al râurilor, speciile de peşti manifestând preferinţe pentru anumite elemente hidraulice (viteză, adâncime, tipul sedimentelor etc. Un habitat sănătos este în mod normal caracterizat printr-o succesiune morfologică de vaduri şi adâncuri cu impact în oxigenarea apei, reproducerea şi hrănirea peştilor etc. Datorită importanţei recreaţionale a pescuitului, în Canada există un număr foarte mare de proiecte de îmbunătăţire a habitatului piscicol. In acest sens, deflectorii amplasaţi în albiile cursurilor de apă s-au dovedit a fi metoda cea mai de succes pentru habitatul păstrăvilor. Pe râul Nicolet (Quebec-Canada a fost monitorizată influenţa unor astfel de structuri inginereşti asupra menţinerii în timp a structurii de adânc. Din analiza evoluţiei morfologice şi morfometrice a adâncurilor (prin folosirea diferitelor ridicări topografice succesive din perioada 2000-2007, rezultă faptul că structurile inginereşti au un rol benefic în menţinerea unui habitat propice pentru peşti.

The Nature of Insurgency in Afghanistan and the Regional Power Politics

Science.gov (United States)

2010-06-01

www.thebulletin.org/web- edition/ columnists /gordon-adams/afghanistan-and-pakistan-the-graveyard-us-foreign-policy-plannin (accessed January 20, 2010). 84 Anotnio...comprising an “insurgent syndicate .”152 This syndicate includes the Afghan Taliban under Mullah Muhammad Omar, who is allegedly operating from... syndicate , Hizb-i-Islami (HiG), is another old Afghan Mujahedeen organization led by Gulbuddin Hekmatyar. HiG received maximum support from the CIA

UL145/ORF

Indian Academy of Sciences (India)

SEARCHU

559. Two-component. Sub classification and targeted characterization of prophage- ... 921. Anand Chaitali. Presence of two types of flowers with respect to nectar sugar in ... Incorporating evolution of transcription factor binding sites into annotated ... Specific and unspecific responses of plants to cold and drought stress. 501.

GenBank blastx search result: AK288311 [KOME

Lifescience Database Archive (English)

Full Text Available (UL26), virion scaffolding protein (UL26.5), virion membrane glycoprotein B (gB), DNA cleavage/packaging pro... subunit (pol), nuclear phosphoprotein (UL31), DNA cleavage/packaging (UL32), DNA cleavage/packaging protein

The agrarian roots of contemporary violent conflict in Mindanao, Southern Philippines

NARCIS (Netherlands)

Vellema, S.; Borras Jr, S.M.; Lare Jr, F.

2011-01-01

The decades-old conflict in Mindanao, southern Philippines, is often framed as a Muslim–Christian conflict and reinterpreted as such within the US-led global war on terror, with the Muslim secessionist movement standing accused of providing a hub for international jihad. In the meantime, global

Evaluating U.S. and EU Trans Sahel Policies

Science.gov (United States)

2013-03-01

elected leaders as well as young Africans who are leaders in civil society and entrepreneurship . Protecting Human Rights, Civil Society, and...GSPC: Newest Franchise in al-Qa‘ida‘s Global Jihad,‖ The Combating Terrorism Center, United States Military Academy, West Point, April 2007, 2. 40

The Muslim Brotherhood and the Perception of Democracy

Science.gov (United States)

2012-12-01

encompasses several genres of literature, such as autobiography, poetry, literary criticism, religiously inspired analytical work and, last but not least...to do with Christians is quickly turned into a cause for jihad.”274 Recent protests over a independent movie filmed in the United States that

Problems and prospects of preservation and conservation of Arabic ...

African Journals Online (AJOL)

The Arabic and Ajami manuscripts are one of the Nigeria's literary and cultural heritage. The manuscripts certainly facilitate greater understanding on the past, present and future of Nigeria's literary and scholarly tradition. The manuscripts, particularly, those written by Sokoto Jihad triumvirate i.e. Sheikh Usman bin ...

Islam and Political Violence

Directory of Open Access Journals (Sweden)

John L Esposito

2015-09-01

Full Text Available The global threat of Al Qaeda post 9/11 and ISIL, increased Sunni-Shia conflicts, and violence in the Middle East and Pakistan dominate headlines and challenge governments in the region and globally. Both Muslim extremists and some Western experts and observers speak of a clash of civilizations or a culture war in Muslim-West relations. Both the discourse and violence yet again raise questions about the relationship of Islam to violence and terrorism: is Islam a particularly violent religion? Critics cite Quranic passages, doctrines like jihad and events in Muslim history as strong indicators and proof that Islam is the primary driver of Muslim extremism and terrorism. What do the Quran and Islamic law have to say about violence, jihad and warfare? What are the primary drivers of terrorism in the name of Islam today? This article will address these questions in the context of development of global jihadist movements, in particular Al Qaeda and ISIL, their roots, causes, ideology and agenda.

Comerţul intraindustrial cu produse agroalimentare in Republica Moldova: aspecte şi tendinţe

Directory of Open Access Journals (Sweden)

Liliana CIMPOIEŞ

2017-06-01

Full Text Available The paper analyzes the agri-food trade of Moldova from different aspects of intra-industry trade. The aim is to estimate the trend and extent of intra-industry trade in agri-food products of Moldova. The time series from 2001-2015 are examined. According to the obtained results, the level of intra-industry trade in agricultural and food products for Moldova is quite high (78%, fact which indicates a decline of trade relationships with EU countries and an increase with CIS countries. For most commodity groups the values of Grubel Lloyd index present a high average variability over time, fact which reflects the structural changes in Moldova’s agri-food trade. The values of A indices are very low and indicate that most of changes in trade flows had been inter-industrial in nature and probably generated high adjustment costs. The switching results of the B index of marginal intra-industry trade indicate that Moldova’s position on these markets considerably improved and strengthened. Rezumat. În lucrarea dată se analizează fluxurile comerciale cu produse agroalimentare din Republica Moldova sub diferite aspecte ale comerţului intraindustrial. Scopul lucrării este de a estima tendinţa şi dimensiunea comerţului intraindustrial cu produse agroalimentare din Republica Moldova. Perioada analizată include datele din anii 2001-2015. Conform rezultatelor obţinute, nivelul comerţului intraindustrial cu produse agroalimentare pentru Republica Moldova este destul de înalt (78%, şi indică asupra unei diminuări în relaţiile comerciale cu ţările Uniunii Europene (UE şi o majorare în ceea ce priveşte ţările din Comunitatea Statelor Independente (CSI. Pentru majoritatea grupelor de mărfuri indicele Grubel Lloyd prezintă o variabilitate medie înaltă pe parcursul perioadei analizate, ceea ce reflectă schimbările structurale ce au avut loc în comerţul agroalimentar al Republicii Moldova. Indicele A prezintă valori joase, ceea ce

Islamic Movements in Algeria and the Strategy of Violence

Science.gov (United States)

2011-03-23

the growing unemployment rate that Algeria experienced especially after the oil prices crash.  The mobilization of Muslims by Saudi Arabia and...group-algeria-islamists/p9154, December 17, 2010, 19 Lianne Kennedy Boudali, “The GSPC: Newest Franchise in al Qa’ida’s Global Jihad,” United States

The Military Application of Narrative: Solving Army Warfighting Challenge #2

Science.gov (United States)

2016-06-10

coalition be out to destroy Islam and spread Christianity if they just aided these men on the most sacred Islamic journey a Muslim could make...recruited and deployed against us. The only requirement is that they subscribe to the religious ideology that is global jihad. — Dr. Sebastian Gorka...

Jihadist Cells and IED Capabilities in Europe: Assessing the Present and Future Threat to the West

Science.gov (United States)

2012-11-01

Miller, “A Prelimi- nary Typology of Organizational Learning: Synthesizing the Lit- erature,” Journal of Management, Vol. 22, No. 3, 1996, pp. 485- 505 ...Alison Pargeter, The New Frontiers of Jihad: Radical Islam in Europe, Philadelphia, PA: University of Pennsylva- nia Press, 2008, chap. 10. 50. It

Problems and prospects of preservation and conservation of Arabic ...

African Journals Online (AJOL)

JEDO INVESTMENT

Abstract. The Arabic and Ajami manuscripts are one of the. Nigeria's literary and cultural heritage. The manuscripts certainly facilitate greater understanding on the past, present and future of Nigeria's literary and scholarly tradition. The manuscripts, particularly, those written by Sokoto Jihad triumvirate i.e. Sheikh. Usman bin ...

Journal for Islamic Studies - Vol 32 (2012)

African Journals Online (AJOL)

Sufism, Education and Politics in Contemporary Morocco · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. R Chih, 24-46. Islamic Reform in Colonial Space: The Jihad of Shaykh Boubacar Sawadogo and French Islamic Policies in Burkina Faso, 1920-1946. EMAIL FULL TEXT ...

Aptitude for Destruction. Volume 1: Organizational Learning in Terrorist Groups and Its Implications for Combating Terrorism

Science.gov (United States)

2005-01-01

jihad in Af- ghanistan. Over its history, the group has had active cells in several different coun- tries, including Indonesia, Malaysia , the...and South Armagh, London, UK: Coronet Books, LIR, 2000. Hedberg, Bo, "How Organizations Learn and Unlearn?" in Paul C. Nystrim and William H. Starbuck

Õhtu kahele / Jaanus Noormets

Index Scriptorium Estoniae

Noormets, Jaanus

2008-01-01

Islamiäärmuslase poolt mõrvatud hollandi režissööri Theo van Goghi mälestuseks tema 2003.a. linastunud filmi põhjal loodud mängufilm "Intervjuu" ("Interview") : režissöör ja peaosatäitja Steve Buscemi : Ameerika Ühendriigid - Holland 2007. Theo van Goghi "Pimekohtingu" (1996) uusversiooni "Blind Date" (2007) tegi Stanley Tucci ning John Turturrol valmib "1-900" 1994.a. filmi "06" põhjal

Applying theory of planned behavior to predict exercise maintenance in sarcopenic elderly

OpenAIRE

Ahmad MH; Shahar S; Teng NIMF; Manaf ZA; Sakian NIM; Omar B

2014-01-01

Mohamad Hasnan Ahmad,1 Suzana Shahar,2 Nur Islami Mohd Fahmi Teng,2 Zahara Abdul Manaf,2 Noor Ibrahim Mohd Sakian,3 Baharudin Omar41Centre of Nutrition Epidemiology Research, Institute of Public Health, Ministry of Health, Kuala Lumpur, Malaysia; 2Dietetics Program, 3Occupational Therapy Program, 4Department of Biomedical Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia Abstract: This study aimed to determine the factors associated with exercise beh...

Al-Zarqawi - terrorist või kangelane? / Kalev Kask

Index Scriptorium Estoniae

Kask, Kalev

2005-01-01

Ilmunud ka: Meie Maa 29. juuni lk. 5. Jordaanias sündinud palestiinlane Abu Musab al-Zarqawi, õige nimega Ahmed Fadel al-Khalaylah, on rühmituse Jama'at al-Tawhid wal Jihad juht ja hetkel kuulsaim sõjapealik Iraagis, kes on pühendanud oma elu võitlusele USA vastu

A Network Design Approach to Countering Terrorism

Science.gov (United States)

2015-09-01

2003). More and more scale-free networks have been discovered. How can such diverse systems have the same architecture and properties? Part of the...Rabei Ousmane Sayed Ahmed (a.k.a. the Egyptian ) convinced the group to pursuit jihad at home, where they had the material resources to act (Atran, 2010

The Indian Jihadist Movement: Evolution and Dynamics

Science.gov (United States)

2014-07-01

and friendship ties.78 In some instances, a person is exposed to the proper “mood music ,” decides he wants to “do” jihad, and looks for assistance...Brigade RDX smuggled from Bangladesh Diwali Festival , Delhi October 29, 2005 IM–Northern Brigade RDX smuggled from Bangladesh; Lashkar-e-Taiba

Banlieue Chronicles

DEFF Research Database (Denmark)

Jørholt, Eva

2017-01-01

, not least juvenile delinquency, ever since the 1960s. While the paper does not go much into the already widely discussed banlieue cinema from the 1980s on, it does take a look at two recent films that address radicalisation, Islamist jihadism as well as violent far-right nationalism, linking both...

BOKO HARAM AND JIHAD IN NIGERIA

African Journals Online (AJOL)

Theo

2012-10-16

Oct 16, 2012 ... aimed at churches, mosques, banks and police stations. ..... exported to the United States, which makes Nigeria the fourth largest oil supplier to .... state structure of Nigeria and the provinces within the federal states.

The Military Strategy of Global Jihad

National Research Council Canada - National Science Library

Zabel, Sara E

2007-01-01

.... Global jihadis have spent more than 40 years refining their philosophy, gaining experience, building their organization, and developing plans to reestablish what they see as the only true Islamic state on earth...

BOKO HARAM AND JIHAD IN NIGERIA

African Journals Online (AJOL)

Theo

2012-10-16

Oct 16, 2012 ... How is Boko Haram positioned within the Muslim community in. Nigeria? How does the group affect the relations between Muslims and Christians? ...... government and elite delinquency finally ripening into social chaos”.54 It ...

Comparison of Self-Report Versus Sensor-Based Methods for Measuring the Amount of Upper Limb Activity Outside the Clinic.

Science.gov (United States)

Waddell, Kimberly J; Lang, Catherine E

2018-03-10

To compare self-reported with sensor-measured upper limb (UL) performance in daily life for individuals with chronic (≥6mo) UL paresis poststroke. Secondary analysis of participants enrolled in a phase II randomized, parallel, dose-response UL movement trial. This analysis compared the accuracy and consistency between self-reported UL performance and sensor-measured UL performance at baseline and immediately post an 8-week intensive UL task-specific intervention. Outpatient rehabilitation. Community-dwelling individuals with chronic (≥6mo) UL paresis poststroke (N=64). Not applicable. Motor Activity Log amount of use scale and the sensor-derived use ratio from wrist-worn accelerometers. There was a high degree of variability between self-reported UL performance and the sensor-derived use ratio. Using sensor-based values as a reference, 3 distinct categories were identified: accurate reporters (reporting difference ±0.1), overreporters (difference >0.1), and underreporters (difference sensor-based assessment. Participants did not consistently or accurately self-report UL performance when compared with the sensor-derived use ratio. Although self-report and sensor-based assessments are moderately associated and appear similar conceptually, these results suggest self-reported UL performance is often not consistent with sensor-measured performance and the measures cannot be used interchangeably. Copyright © 2018 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

NKGB-UL SOVIETIC PE FRONTUL INVIZIBIL ÎN BASARABIA, MARTIE-IUNIE 1944

Directory of Open Access Journals (Sweden)

Alexandru MALACENCO

2016-12-01

Full Text Available O incursiune sumară în tematica cercetării atestă că în anii celui de-al Doilea Război Mondial activitatea serviciilor speciale ale URSS, ca instrument coercitiv al puterii politice, era determinată „în funcție de acțiunea ofensivă sau defensivă a trupelor sovietice. Apariția NKGB-ului sovietic – structură menită să lupte cu dușmanii statului/regimului sovietic – se producea ori de câte ori armata sovietică urma să se lanseze în ofensivă, scopul fiind, desigur, „purificarea” de ele­mente ostile a teritoriului” recucerit, ce constituia o etapă inerentă în procesul (resovietizării acestor spații.Istoria celui de-al Doilea Război Mondial arată că acolo unde călca Armata Roșie se impunea și regimul comunist. Grosso modo, URSS în anii războiului opera cu mai multe armate pe câmpul de luptă în misiunea de „eliberare” a țărilor din Europa: Armata Roșie, care lupta pe frontul militar și Armata de trupe speciale, care lupta pe frontul invizibil.Așadar, la sfârșitul lunii martie 1944, trupele Armatei Roșii au reușit să forțeze linia frontului peste Nistru și să reocupe partea de nord a Basarabiei, iar pentru scurt timp orașul Soroca a devenit capitala administrativă a Moldovei sovietice. Odată cu trupele sovietice, în nordul Basarabiei au revenit și structurile de securitate ale URSS. Printre primele instituții sovietice care s-au stabilit inițial cu sediulla Sorocaa fost Comisariatul Poporului pentru Securitatea Statului – NKGB. În fruntea NKGB-ului din RSSM a fost numit ucraineanul Iosif Mordoveț (1944-1955, care a avut ca obiectiv reorganizarea aparatului de securitate pe teritoriul Basarabiei reocupate, fapt ce a determinat soarta acestui spațiu aproximativ pentru jumătate de secol înainte.SOVIET NKGB ON THE INVISIBLE FRONT IN BASARABIA, MARCH - JUNE 1944A short insight into the subject of this study highlights that in the period of the Second World War the activity of

Regulation of 2-5A Dependent RNase at the Level of its Phosphorylation

Science.gov (United States)

1991-06-26

extract as follows: 25 ul wheat germ extract 10 ul H2O 1 ul RNasin ribonuclease inhibitor (40 u/ml) 7 ul ImM amino acid mixture 1 ul IM...diacylglycerol (DAG) 2. TPA 3. Indolactam Figure 6. Chemical structure of: 1. H-7 (A kinase inhibitor) 2. okadaic acid (A phosphatase inhibitor) Figure 7...elevating agents: Forskolin and Cholera toxin Figure 17. Down-regulation of 2-5A-depRNase by Okadaic 77 acid : A phosphatase inhibitor Figure 18

A Tool for Monitoring of YouTube Content

DEFF Research Database (Denmark)

Lashari, Intzar Ali; Wiil, Uffe Kock

2014-01-01

in abundance from social media is difficult. This paper describes a new tool that can collect, monitor, and mine data from YouTube. The tool is part of a larger framework aimed at monitoring various social media including Facebook, Twitter, and YouTube. A specific case focusing on “Islamic Jihad Holy War...

The Role of Religion in Human Development | Ugorie | UJAH: Unizik ...

African Journals Online (AJOL)

Religion has been destructively criticized and is still passing through criticisms. This is due largely to the sufferings and devastated situations humanity has passed through over the centuries as a result of many wars caused or justified by religion. The Islamic Jihads, the Crusades, the European Religious Wars, are some of ...

Overlapping transcription structure of human cytomegalovirus

Indian Academy of Sciences (India)

Transcription of human cytomegalovirus UL/b′ region has been studied extensively for some genes. In this study, transcripts of the UL140 and UL141, two of the UL/b′ genes, were identified in late RNAs of three HCMV isolates using Northern blot hybridization, cDNA library screening and RACE-PCR. At least three ...

Overlapping transcription structure of human cytomegalovirus ...

Indian Academy of Sciences (India)

2013-01-21

Jan 21, 2013 ... Transcription of human cytomegalovirus UL/b′ region has been studied extensively for some genes. In this study, transcripts of the UL140 and UL141, two of the UL/b′ genes, were identified in late RNAs of three HCMV isolates using Northern blot hybridization, cDNA library screening and RACE-PCR.

78 FR 70329 - Modification to the Scopes of Recognition of Several NRTLs; Final Determination

Science.gov (United States)

2013-11-25

... Assemblies, Including Positive Pressure Testing of Side-Hinged and Pivoted Swinging Door Assemblies. ANSI...--Part 11: Type C (Edison Base) and Type S Plug Fuse; UL 4248-12-- Fuseholders--Part 12: Class R; UL 4248... (Edison Base) and Type S Plug Fuse UL 4248-12 Fuseholders--Part 12: Class R UL 4248-15 Fuseholders--Part...

Islamic literature and Sastera Islami: A Conceptual Comparison

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Rahmah bt. Ahmad H. Osman

2006-06-01

Full Text Available Normal 0 false false false EN-MY X-NONE AR-SA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Abstract: A comparative analysis of the Middle Eastern and Malay Islamic literatures shows that in both traditions, there is an emphasis on morality and good values. However, the discussion on Islamic literature in the Middle East is more philosophically-rooted compared to the Malay literature which is in tune with Malay tradition and is focussed on the daily necessities of life.

STRATEGI PEMBANGUNAN EKONOMI YANG ISLAMI MENURUT FAHIM KHAN

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Ali Murtadho

2016-10-01

Full Text Available Several theories about the development strategy formulated by the most conventional neo-classical economists much criticized. Fahim Khan including contemporary Islamic economic thinkers who criticize conventional economic development strategy with alternative bids from the Islamic economics perspective. Their thinking is exciting to examined substance and its correlation with the economic development of contemporary Islamic discourse that dominated the development of financial institutions/syariah banking. The creation of entrepreneurial opportunities made Fahim Khan as a keyword in the concept of criticizing conventional strategy and supporting the Islamic economic development strategy. Strategy opened and graced this productive creative independent businesses are deemed appropriate and supported by the Islamic economic system based on profit and loss sharing partnership (profit-loss sharing. The idea is to promote excellence banking system of sharing based on the conventional interest-based banking system in spurring economic development suplus to enliven the entrepreneurial workforce.

STRATEGI PEMBANGUNAN EKONOMI YANG ISLAMI MENURUT FAHIM KHAN

OpenAIRE

Ali Murtadho

2017-01-01

Several theories about the development strategy formulated by the most conventional neo-classical economists much criticized. Fahim Khan including contemporary Islamic economic thinkers who criticize conventional economic development strategy with alternative bids from the Islamic economics perspective. Their thinking is exciting to examined substance and its correlation with the economic development of contemporary Islamic discourse that dominated the development of financial institutions/sy...

PSIKOTERAPI ISLAMI TERHADAP PSIKOPATOLOGI (Perspektif Psikologi Pendidikan Islam

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Evita Yuliatul Wahidah

2017-01-01

Full Text Available In a review of psychology, psychopathology can be started from three assumptions. First, the Freudian assumed that the human soul was basically born in sickness, evil, negative / destructive. To be positive, it need companion ways that are impersonal and directive / directing. Second, as a behaviorist, Skinner assumed that the human soul was born in neutral (not sick and unhealthy, where the environment plays a role in determining the direction of its development. Third, Maslow and Rogers as a humanistic figure assumed that the human soul was born in a state of conscious, free, responsible and guided by positive forces emanating from itself to the expansion of all human potential to its fullest. Whereas in Islamic studies of psychopathology can be divided into two categories, namely the worldly, as has been formulated by contemporary psychology, and the hereafter. This paper attempts to explain kinds of psychotherapy according to the study of Islam and how Islam is doing its part in the psychotherapy world and ukhrowi psychopathology. Discussion of Islam against psychopathology of psychotherapy becomes important. In addition to see the growing of Islamization method, as well as to explore therapist aspects in Islam based on the Qur'an and Hadith. The Islamic Psychotherapy is also to provide an alternative to the criticisms made against modern psychology that break away from the values of divinity. This paper begins his discussion of the notion of Psychopathology, Islamic psychotherapy understanding and the existing concept of the theories.

Factors affecting the loss of MED12-mutated leiomyoma cells during in vitro growth

OpenAIRE

Bloch, Jeannine; Holzmann, Carsten; Koczan, Dirk; Helmke, Burkhard Maria; Bullerdiek, J?rn

2017-01-01

Uterine leiomyomas (UL) are the most prevalent symptomatic human tumors at all and somatic mutations of the gene encoding mediator subcomplex 12 (MED12) constitute the most frequent driver mutations in UL. Recently, a rapid loss of mutated cells during in vitro growth of UL-derived cell cultures was reported, resulting in doubts about the benefits of UL-derived cell cultures. To evaluate if the rapid loss of MED12-mutated cells in UL cell cultures depends on in vitro passaging, we set up cell...

In Vivo Imaging of Glial Activation after Unilateral Labyrinthectomy in the Rat: A [18F]GE180-PET Study

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Andreas Zwergal

2017-12-01

Full Text Available The functional relevance of reactive gliosis for recovery from acute unilateral vestibulopathy is unknown. In the present study, glial activation was visualized in vivo by [18F]GE180-PET in a rat model of unilateral labyrinthectomy (UL and compared to behavioral vestibular compensation (VC overtime. 14 Sprague-Dawley rats underwent a UL by transtympanic injection of bupivacaine/arsenilate, 14 rats a SHAM UL (injection of normal saline. Glial activation was depicted with [18F]GE180-PET and ex vivo autoradiography at baseline and 7, 15, 30 days after UL/SHAM UL. Postural asymmetry and nystagmus were registered at 1, 2, 3, 7, 15, 30 days after UL/SHAM UL. Signs of vestibular imbalance were found only after UL, which significantly decreased until days 15 and 30. In parallel, [18F]GE180-PET and ex vivo autoradiography depicted glial activation in the ipsilesional vestibular nerve and nucleus on days 7 and 15 after UL. Correlation analysis revealed a strong negative association of [18F]GE180 uptake in the ipsilesional vestibular nucleus on day 7 with the rate of postural recovery (R = −0.90, p < 0.001, suggesting that glial activation accelerates VC. In conclusion, glial activation takes place in the ipsilesional vestibular nerve and nucleus within the first 30 days after UL in the rat and can be visualized in vivo by [18F]GE180-PET.

CTC Sentinel. Volume 7, Issue 9, September 2014

Science.gov (United States)

2014-09-01

to cottage in the summertime, I loved to fish, I wanted to go hunting, I liked outdoors, I liked sports …life in Canada was good. I had money, I...Almani. 34 Soraya Sarhaddi Nelson, “‘Jihad Tourism ’: From Ger- many to the Syrian Battlefield,” National Public Radio, December 22, 2013. Assessing

What Does it Take to Be a True Muslim? Implications for Efforts to Counter al-Qa’ida’s Violent Extremist Narrative

Science.gov (United States)

2014-01-01

4 Evolution of the AQ Narrative: The Salafist-Jihadist Movement ............................................ 5 Salafism ...extremists with whom AQAA shares its underlying ideology: Salafism . The Salafi movement offers Salafi-Jihadists like AQAA fertile ground planted with...violent extremism (in this case, from non-violent Salafism to Salafi-Jihadism). This paper addresses this issue and surrounding dynamics within the

A Dual-Modality Herpes Simplex Virus 2 Vaccine for Preventing Genital Herpes by Using Glycoprotein C and D Subunit Antigens To Induce Potent Antibody Responses and Adenovirus Vectors Containing Capsid and Tegument Proteins as T Cell Immunogens.

Science.gov (United States)

Awasthi, Sita; Mahairas, Gregory G; Shaw, Carolyn E; Huang, Meei-Li; Koelle, David M; Posavad, Christine; Corey, Lawrence; Friedman, Harvey M

2015-08-01

We evaluated a genital herpes prophylactic vaccine containing herpes simplex virus 2 (HSV-2) glycoproteins C (gC2) and D (gD2) to stimulate humoral immunity and UL19 (capsid protein VP5) and UL47 (tegument protein VP13/14) as T cell immunogens. The HSV-2 gC2 and gD2 proteins were expressed in baculovirus, while the UL19 and UL47 genes were expressed from replication-defective adenovirus vectors. Adenovirus vectors containing UL19 and UL47 stimulated human and murine CD4(+) and CD8(+) T cell responses. Guinea pigs were either (i) mock immunized; (ii) immunized with gC2/gD2, with CpG and alum as adjuvants; (iii) immunized with the UL19/UL47 adenovirus vectors; or (iv) immunized with the combination of gC2/gD2-CpG/alum and the UL19/UL47 adenovirus vectors. Immunization with gC2/gD2 produced potent neutralizing antibodies, while UL19 and UL47 also stimulated antibody responses. After intravaginal HSV-2 challenge, the mock and UL19/UL47 adenovirus groups developed severe acute disease, while 2/8 animals in the gC2/gD2-only group and none in the combined group developed acute disease. No animals in the gC2/gD2 or combined group developed recurrent disease; however, 5/8 animals in each group had subclinical shedding of HSV-2 DNA, on 15/168 days for the gC2/gD2 group and 13/168 days for the combined group. Lumbosacral dorsal root ganglia were positive for HSV-2 DNA and latency-associated transcripts for 5/8 animals in the gC2/gD2 group and 2/8 animals in the combined group. None of the differences comparing the gC2/gD2-only group and the combined group were statistically significant. Therefore, adding the T cell immunogens UL19 and UL47 to the gC2/gD2 vaccine did not significantly reduce genital disease and vaginal HSV-2 DNA shedding compared with the excellent protection provided by gC2/gD2 in the guinea pig model. HSV-2 infection is a common cause of genital ulcer disease and a significant public health concern. Genital herpes increases the risk of transmission and

The convenient enemy – neocons, global jihadists and the road to Iraq

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Carlos Gustavo Poggio Teixeira

2011-05-01

Full Text Available Ideologically, the Iraq War was a product of the encounter of global jihadism and neoconservatism. Prior to September 11, 2001, both were facing enormous difficulties in keeping their appeal as compelling discourses within their respective societies. Nevertheless, 9-11 revived neoconservatism by giving them the ideological enemy neoconservatives were longing calling for, leading to the invasion of Iraq on March 20, 2003 which, in turn, reenergized global jihadism.   Em termos ideológicos, a Guerra do Iraque foi resultado do encontro entre jihadismo global e neoconservadorismo. Antes de 11 de setembro de 2001, ambos passavam por enormes dificuldades no sentido de manter seu apelo enquanto discursos legítimos no contexto de suas respectivas sociedades.Entretanto, os ataques de 11 de setembro reavivaram o neoconservadorismo na medida em que forneceu aos neoconservadores o necessário inimigo ideológico clamado pelos mesmos, levando à invasão do Iraque em 20 de março de 2003 que, por sua vez, revitalizou o jihadismo global.

Sharia Adherence Mosque Survey: Correlations between Sharia Adherence and Violent Dogma in U.S. Mosques

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Mordechai Kedar

2011-12-01

Full Text Available A random survey of 100 representative mosques in the U.S. was conducted to measure the correlation between Sharia adherence and dogma calling for violence against non-believers.  Of the 100 mosques surveyed, 51% had texts on site rated as severely advocating violence; 30% had texts rated as moderately advocating violence; and 19% had no violent texts at all.  Mosques that presented as Sharia adherent were more likely to feature violence-positive texts on site than were their non-Sharia-adherent counterparts.  In 84.5% of the mosques, the imam recommended studying violence-positive texts.  The leadership at Sharia-adherent mosques was more likely to recommend that a worshipper study violence-positive texts than leadership at non-Sharia-adherent mosques.  Fifty-eight percent of the mosques invited guest imams known to promote violent jihad.  The leadership of mosques that featured violence-positive literature was more likely to invite guest imams who were known to promote violent jihad than was the leadership of mosques that did not feature violence-positive literature on mosque premises.  

Identification of multiple sites suitable for insertion of foreign genes in herpes simplex virus genomes.

Science.gov (United States)

Morimoto, Tomomi; Arii, Jun; Akashi, Hiroomi; Kawaguchi, Yasushi

2009-03-01

Information on sites in HSV genomes at which foreign gene(s) can be inserted without disrupting viral genes or affecting properties of the parental virus are important for basic research on HSV and development of HSV-based vectors for human therapy. The intergenic region between HSV-1 UL3 and UL4 genes has been reported to satisfy the requirements for such an insertion site. The UL3 and UL4 genes are oriented toward the intergenic region and, therefore, insertion of a foreign gene(s) into the region between the UL3 and UL4 polyadenylation signals should not disrupt any viral genes or transcriptional units. HSV-1 and HSV-2 each have more than 10 additional regions structurally similar to the intergenic region between UL3 and UL4. In the studies reported here, it has been demonstrated that insertion of a reporter gene expression cassette into several of the HSV-1 and HSV-2 intergenic regions has no effect on viral growth in cell culture or virulence in mice, suggesting that these multiple intergenic regions may be suitable HSV sites for insertion of foreign genes.

Herpesvirus capsid assembly and DNA packaging

Science.gov (United States)

Heming, Jason D.; Conway, James F.; Homa, Fred L.

2017-01-01

Herpes simplex virus type I (HSV-1) is the causative agent of several pathologies ranging in severity from the common cold sore to life-threatening encephalitic infection. During productive lytic infection, over 80 viral proteins are expressed in a highly regulated manner, resulting in the replication of viral genomes and assembly of progeny virions. The virion of all herpesviruses consists of an external membrane envelope, a proteinaceous layer called the tegument, and an icosahedral capsid containing the double-stranded linear DNA genome. The capsid shell of HSV-1 is built from four structural proteins: a major capsid protein, VP5, which forms the capsomers (hexons and pentons), the triplex consisting of VP19C and VP23 found between the capsomers, and VP26 which binds to VP5 on hexons but not pentons. In addition, the dodecameric pUL6 portal complex occupies one of the 12 capsid vertices, and the capsid vertex specific component (CVSC), a heterotrimer complex of pUL17, pUL25 and pUL36 binds specifically to the triplexes adjacent to each penton. The capsid is assembled in the nucleus where the viral genome is packaged into newly assembled closed capsid shells. Cleavage and packaging of replicated, concatemeric viral DNA requires the seven viral proteins encoded by the UL6, UL15, UL17, UL25, UL28, UL32, and UL33 genes. Considerable advances have been made in understanding the structure of the herpesvirus capsid and the function of several of the DNA packaging proteins by applying biochemical, genetic, and structural techniques. This review is a summary of recent advances with respect to the structure of the HSV-1 virion capsid and what is known about the function of the seven packaging proteins and their interactions with each other and with the capsid shell. PMID:28528442

Misconceptions about Human Rights and Women's Rights in Islam

Science.gov (United States)

Syed, Khalida Tanvir

2008-01-01

This paper aims to clarify three current misconceptions about the Islamic faith and issues of human rights and women's rights in the West. The first misconception is that Muslims are terrorists because they believe in Jihad. It is factually the case that Islamic teachings stress the value of peace and prosperity for all human beings. The second…

Teaching about Islam and Women: On Pedagogy and the Personal

Science.gov (United States)

Barlas, Asma

2007-01-01

In this article, the author shares the challenges she faced as a teacher who teaches "Understanding Islam: Religion and Politics." She shares that most of the strains she had experienced began to surface when her class came to the segments on jihad and Muslim women. She also relates that some of the tensions experienced by her students result from…

Radicalization: An Overview and Annotated Bibliography of Open-Source Literature

Science.gov (United States)

2006-12-15

particularly with liberal, democratic, and humanistic Muslims Phares points to Jihadism as the main root cause of terrorism and suggests that defending...An Overview and Annotated Bibliography of Open-Source Literature 155 of ambiguity), epistemic and existential needs theory (need for closure...This book presents Terror Management Theory, which addresses behavioral and psychological responses to terrorist events. An existential

Engaging Afghans KLE Keys to Success

OpenAIRE

Moss, Don

2009-01-01

This article was published in Culture and Conflict Review (Fall 2009), v.3 no.3 "A pillar of Coalition Force/United States Government (USG) efforts in Afghanistan is to separate the people of the Islamic Republic of Afghanistan from insurgent groups such as the Taliban, Haqqani Network and Hezb-e-Islami Gulbuddin (HiG) and unite the same populace with their fledgling government. In order to do this, the men and women undertaking this effort have access to the latest in information, trainin...

Radical Islamism and Failed Developmentalism

OpenAIRE

Rahnema, Saeed

2008-01-01

The rise of radical Islamism in recent years does not limit the applicability of the concept of cultural nationalism. Rather the two are intertwined in ways which this article will attempt to highlight. Islam took specific national forms as modern nation-states arose and the contemporary resurgence of radical Islamism also follows that modern pattern. I examine the emergence of the three most important movements in the Islamic world, namely, the Muslim Brotherhood in Egypt, Jama'at-e Islami i...

Typological Study of Traditional Mosque Ornamentation in Malaysia – Prospect of Traditional Ornament in Urban Mosque

OpenAIRE

N. Utaberta; S. D. M. Sojak; M. Surat; A. I. Che-Ani; M.M. Tahir

2012-01-01

Since the admission of Islam onto the Malay World in 16th century, the Malay culture began to grow in line with the teachings of Islam as a guide of life. Mosque become a symbol of Muslim communities, as well as the cultural values that have been adapted represent the maturity and readiness of Malay Muslim in manifest a lifestyle tradition into the community. Refinement of ornament that used to take from Hindu-Buddhist beliefs before were adopted and refined to the Islami...

78 FR 52568 - TUV SUD America, Inc.: Modification of Scope of Recognition

Science.gov (United States)

2013-08-23

... standards (1) UL 551 Transformer-type Arc-welding Machine, (2) UL 1484 Residential Gas Detectors, and (3) UL 1662 Electric Chain Saws from TUVAM's scope of recognition as of August 23, 2013. As of August 23, 2013...

Human Cytomegalovirus Nuclear Egress Proteins Ectopically Expressed in the Heterologous Environment of Plant Cells are Strictly Targeted to the Nuclear Envelope.

Science.gov (United States)

Lamm, Christian E; Link, Katrin; Wagner, Sabrina; Milbradt, Jens; Marschall, Manfred; Sonnewald, Uwe

2016-03-10

In all eukaryotic cells, the nucleus forms a prominent cellular compartment containing the cell's nuclear genome. Although structurally similar, animal and plant nuclei differ substantially in details of their architecture. One example is the nuclear lamina, a layer of tightly interconnected filament proteins (lamins) underlying the nuclear envelope of metazoans. So far no orthologous lamin genes could be detected in plant genomes and putative lamin-like proteins are only poorly described in plants. To probe for potentially conserved features of metazoan and plant nuclear envelopes, we ectopically expressed the core nuclear egress proteins of human cytomegalovirus pUL50 and pUL53 in plant cells. pUL50 localizes to the inner envelope of metazoan nuclei and recruits the nuclear localized pUL53 to it, forming heterodimers. Upon expression in plant cells, a very similar localization pattern of both proteins could be determined. Notably, pUL50 is specifically targeted to the plant nuclear envelope in a rim-like fashion, a location to which coexpressed pUL53 becomes strictly corecruited from its initial nucleoplasmic distribution. Using pUL50 as bait in a yeast two-hybrid screening, the cytoplasmic re-initiation supporting protein RISP could be identified. Interaction of pUL50 and RISP could be confirmed by coexpression and coimmunoprecipitation in mammalian cells and by confocal laser scanning microscopy in plant cells, demonstrating partial pUL50-RISP colocalization in areas of the nuclear rim and other intracellular compartments. Thus, our study provides strong evidence for conserved structural features of plant and metazoan nuclear envelops and identifies RISP as a potential pUL50-interacting plant protein.

A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance.

Science.gov (United States)

Chou, Sunwen

2017-12-01

Letermovir is a human cytomegalovirus (CMV) terminase inhibitor that was clinically effective in a Phase III prevention trial. In vitro studies have shown that viral mutations conferring letermovir resistance map primarily to the UL56 component of the terminase complex and uncommonly to UL89. After serial culture of a baseline CMV laboratory strain under letermovir, mutation was observed in a third terminase component in 2 experiments, both resulting in amino acid substitution P91S in gene UL51 and adding to a pre-existing UL56 mutation. Recombinant phenotyping indicated that P91S alone conferred 2.1-fold increased letermovir resistance (EC50) over baseline, and when combined with UL56 mutation S229F or R369M, multiplied the level of resistance conferred by those mutations by 3.5-7.7-fold. Similarly a combination of UL56 mutations S229F, L254F and L257I selected in the same experiment conferred 54-fold increased letermovir EC50 over baseline, but 290-fold when combined with UL51 P91S. The P91S mutant was not perceptibly growth impaired. Although pUL51 is essential for normal function of the terminase complex, its biological significance is not well understood. Letermovir resistance mutations mapping to 3 separate genes, and their multiplier effect on the level of resistance, suggest that the terminase components interactively contribute to the structure of a letermovir antiviral target. The diagnostic importance of the UL51 P91S mutation arises from its potential to augment the letermovir resistance of some UL56 mutations at low fitness cost. Copyright © 2017 Elsevier B.V. All rights reserved.

A Downlink and Uplink Alignment Scheme for Power Saving in IEEE 802.16 Protocol

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Jenhui Chen

2014-01-01

Full Text Available This study shows the problem of power saving mechanism (PSM that sleep intervals of uplink (UL connections do not synchronize with sleep intervals of downlink (DL connections. That is, the energy of a mobile station (MS is not really saved if the DL connections are in the sleep mode while the UL connections are in normal mode, and vice versa. To avoid the asynchronism of power saving (PS between UL and DL connections, we invent a mechanism of DL connections regulating UL connections, called DL and UL Alignment (DUAL scheme, to improve the energy efficiency for PS. Considering that the buffer size of MS is limited, DUAL uses the mean packet arrival rate of UL λu and a relatively safe threshold of buffer size QT as the parameters to estimate the maximum allowable waiting time to align the UL with the DL connections. To analyze the performance of DUAL, a system model of PS is proposed to evaluate the performance of DUAL under different conditions. The correctness of performance analysis of DUAL is validated by using simulation with realistic parameters. Numerical experiments show that DUAL improves the energy conservation significantly when UL traffic is greater than DL traffic.

Association of FAS A-670G Polymorphism and Risk of Uterine Leiomyoma in a Southeast Iranian Population

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Abbas Mohammadpour-Gharehbagh

2016-10-01

Full Text Available Background: Uterine leiomyoma (UL is a benign tumor of uterine smooth muscle that affects women in reproductive ages. FAS has an important role in initial stages of apoptosis. Previous studies have shown an association between the FAS gene and tumorigenesis. In the present study, we evaluated the relationship between FAS A-670G (rs 1800682 and UL risk. Methods: The FAS gene polymorphism of 155 women with UL and 157 healthy controls was analyzed by the polymerase chain reaction restriction fragment length polymorphism method. Results: The AA, AG, and GG genotype frequencies of the FAS A-670G polymorphism were respectively 37.4, 42.6, and 20% in women with UL, and 46, 42.6, and 11.5% in healthy controls. The risk of UL in women was 1.5-fold greater in GG-genotype women than in AA-genotype women. The G allele frequencies were 41% in women with UL and 33% in healthy controls and statistically different (P = 0.03. Conclusions: The FAS polymorphism was associated with the risk of UL in a sample of Iranian women.

Association of FAS A-670G Polymorphism and Risk of Uterine Leiomyoma in a Southeast Iranian Population

Science.gov (United States)

Mohammadpour-Gharehbagh, Abbas; Salimi, Saeedeh; Keshavarzi, Farshid; Zakerian, Sepideh; Sajadian, Mojtaba; Mokhtari, Mojgan

2016-01-01

Background: Uterine leiomyoma (UL) is a benign tumor of uterine smooth muscle that affects women in reproductive ages. FAS has an important role in initial stages of apoptosis. Previous studies have shown an association between the FAS gene and tumorigenesis. In the present study, we evaluated the relationship between FAS A-670G (rs 1800682) and UL risk Methods: The FAS gene polymorphism of 155 women with UL and 157 healthy controls was analyzed by the polymerase chain reaction restriction fragment length polymorphism method Results: The AA, AG, and GG genotype frequencies of the FAS A-670G polymorphism were respectively 37.4, 42.6, and 20% in women with UL, and 46, 42.6, and 11.5% in healthy controls. The risk of UL in women was 1.5-fold greater in GG-genotype women than in AA-genotype women. The G allele frequencies were 41% in women with UL and 33% in healthy controls and statistically different (P = 0.03) Conclusion: The FAS polymorphism was associated with the risk of UL in a sample of Iranian women. PMID:28070535

Secure Multi-party Computation Protocol for Defense Applications in Military Operations Using Virtual Cryptography

Science.gov (United States)

Pathak, Rohit; Joshi, Satyadhar

With the advent into the 20th century whole world has been facing the common dilemma of Terrorism. The suicide attacks on US twin towers 11 Sept. 2001, Train bombings in Madrid Spain 11 Mar. 2004, London bombings 7 Jul. 2005 and Mumbai attack 26 Nov. 2008 were some of the most disturbing, destructive and evil acts by terrorists in the last decade which has clearly shown their evil intent that they can go to any extent to accomplish their goals. Many terrorist organizations such as al Quaida, Harakat ul-Mujahidin, Hezbollah, Jaish-e-Mohammed, Lashkar-e-Toiba, etc. are carrying out training camps and terrorist operations which are accompanied with latest technology and high tech arsenal. To counter such terrorism our military is in need of advanced defense technology. One of the major issues of concern is secure communication. It has to be made sure that communication between different military forces is secure so that critical information is not leaked to the adversary. Military forces need secure communication to shield their confidential data from terrorist forces. Leakage of concerned data can prove hazardous, thus preservation and security is of prime importance. There may be a need to perform computations that require data from many military forces, but in some cases the associated forces would not want to reveal their data to other forces. In such situations Secure Multi-party Computations find their application. In this paper, we propose a new highly scalable Secure Multi-party Computation (SMC) protocol and algorithm for Defense applications which can be used to perform computation on encrypted data. Every party encrypts their data in accordance with a particular scheme. This encrypted data is distributed among some created virtual parties. These Virtual parties send their data to the TTP through an Anonymizer layer. TTP performs computation on encrypted data and announces the result. As the data sent was encrypted its actual value can’t be known by TTP

[Upper limb work-related musculoskeletal disorders (UL-WMSDs): a retrospective cohort study in three large factories of the upholstered furniture industry].

Science.gov (United States)

Nicoletti, S; Consonni, D; Carino, M; Di Leone, G; Trani, G; Battevi, N; Colombini, Daniela; Ambrosi, L

2008-01-01

The epidemiological evidence of work-related musculoskeletal disorders (UL-WMSDs) due to repetitive strain and movements in the various industries has been collected in the literature mainly through cross-sectional surveys. In particular there are no contributions so far regarding the upholstered furniture industry with a longitudinal design. The aim of the study was to evaluate the incidence rate of WMSDs such as hand-wrist and shoulder tendonitis, carpal tunnel syndrome, and epicondylitis in exposed workers of three large companies of the upholstered furniture industry in a large geographic area of southern Italy. The OCRA method, recommended by international standard ISO 11228-3 and EN 1005-5, was used for risk assessment. The following work tasks were considered:.filling preparation workers, leather-cutting operators, sewing and upholstery-assembly workers. A total population of 5,278 subjects (exposed n=2927, controls n=2351) was investigated. The person/year at risk parameters were calculated from 1 January 2000, or from the date of engagement if later, until the first diagnosis of WMSD or, in absence of disorders, until the end of the study, i.e. 31 December 2004. Disorders occurring after the first were not considered. A multiple regression analysis was used to evaluate relationships between rates. Incidence rates correlated with risk classes of the OCRA index. An incidence rate of WMSDs higher than 1.2 cases per 100 person/year may be considered as a threshold value to suspect an occupational exposure to repetitive strain and movements warranting further investigation. The analysis of single factors did not show a greater predisposition of the female gender, with the single exception of the carpal tunnel syndrome (RR 2.92; 95% CI 1.57-5.43). Shoulder disorders affected mainly male leather-cutting operators (RR 4.97; 95% CI 2.03-12.16) and among all the factors influencing risk (frequency, force, posture, additional risk factors, pauses) posture seems to

Holocene palaeohydrological history of the Tǎul Muced peat bog (Northern Carpathians, Romania) based on testate amoebae (Protozoa) and plant macrofossils

Science.gov (United States)

Cosmin Diaconu, Andrei; Feurdean, Angelica; Lamentowicz, Mariusz; Gałka, Mariusz; Tanţǎu, Ioan

2016-04-01

Knowledge of past local vs. regional hydro-climate variability is a priority in climate research. This is because ecosystems and human depend on local climatic conditions and the magnitude of these climate changes is more variable at local and regional rather than at global scales. Ombrotrophic bogs are highly suitable for hydro-climate reconstructions as they are entirely dependent on the water from precipitation. We used stratigraphy, radiocarbon dating, testate amoebae (TA) and plant macrofossils on a peat profile from an ombrotrophic bog (Tǎul Muced) located in the Biosphere Reserve of the Rodna National Park Romania. We performed quantitative reconstruction of the depth to water table (DWT) and pH over the last 8000 years in a continental area of CE Europe. We identified six main stages in the development of the bog based on changes in TA assemblages in time. Wet conditions and pH between 2 and 4.5 were recorded between 4600-2750 and 1300-400 cal. yr BP, by the occurrence of Archerella flavum, Amphitrema wrightianum and Hyalosphenia papilio. This was associated to a local vegetation primarily composed of Sphagnum magellanicum and S. angustifolium. Dry stages and pH of 2.5 to 5 were inferred between 7550-4600, 2750-1300 and -50 cal. yr BP, by the dominance of Nebela militaris, Difflugia pulex and Phryganella acropodia. These overall dry conditions were also connected with increased abundance of Eriophorum vaginatum. The period between 400 and -50 cal. yr BP was characterized by a rapid shift from dry to wet conditions on the surface of the bog. Vegetation shifted from Sphagnum magellanicum to Sphagnum russowii dominated community. Our reconstruction remains in relatively good agreement with other palaeohydrological records from Central Eastern Europe. However, it shows contrasting conditions to others particularly with records from NW Europe. The valuable information regarding bog hydrology offered by our record puts an accent on the need of more regional TA

The Prevalence and Nature of Unrequited Love

Directory of Open Access Journals (Sweden)

Robert G. Bringle

2013-06-01

Full Text Available Unrequited love (UL is unreciprocated love that causes yearning for more complete love. Five types of UL are delineated and conceptualized on a continuum from lower to greater levels of interdependence: crush on someone unavailable, crush on someone nearby, pursuing a love object, longing for a past lover, and an unequal love relationship. Study 1a found all types of UL relationships to be less emotionally intense than equal love and 4 times more frequent than equal love during a 2-year period. Study 1b found little evidence for limerent qualities of UL. Study 2 found all types of UL to be less intense than equal love on passion, sacrifice, dependency, commitment, and practical love, but more intense than equal love on turmoil. These results suggest that UL is not a good simulation of true romantic love, but an inferior approximation of that ideal.

Urban underground logistics system in China: Opportunities or challenges?

Directory of Open Access Journals (Sweden)

Zhilong Chen

2017-09-01

Full Text Available An urban underground logistics system (ULS is one important means of solving urban traffic problems that has unique advantages. Freight transportation in China requires a new transportation mode. Therefore, ULS has garnered increasing attention. However, to date, few scholars and practitioners have investigated ULS in China. Although ULS shows good development opportunities, it also faces great challenges. Based on the Macro-environment and situation analysis (PEST-SWOT model, which is a strategic analysis method that combines both SWOT and PEST to effectively identify advantages, disadvantages, opportunities and threats, this paper first uses PEST to analyze the macro-environment of ULS in China and identify its internal factors (i.e., advantages and disadvantages and external factors (i.e., opportunities and threats. Next, based on the SWOT framework, this paper proposes several development strategies and recommendations that provide a comprehensive and novel perspective to the study of ULS in China.

Model-based iterative reconstruction and adaptive statistical iterative reconstruction: dose-reduced CT for detecting pancreatic calcification

International Nuclear Information System (INIS)

Yasaka, Koichiro; Katsura, Masaki; Akahane, Masaaki; Sato, Jiro; Matsuda, Izuru; Ohtomo, Kuni

2016-01-01

Iterative reconstruction methods have attracted attention for reducing radiation doses in computed tomography (CT). To investigate the detectability of pancreatic calcification using dose-reduced CT reconstructed with model-based iterative construction (MBIR) and adaptive statistical iterative reconstruction (ASIR). This prospective study approved by Institutional Review Board included 85 patients (57 men, 28 women; mean age, 69.9 years; mean body weight, 61.2 kg). Unenhanced CT was performed three times with different radiation doses (reference-dose CT [RDCT], low-dose CT [LDCT], ultralow-dose CT [ULDCT]). From RDCT, LDCT, and ULDCT, images were reconstructed with filtered-back projection (R-FBP, used for establishing reference standard), ASIR (L-ASIR), and MBIR and ASIR (UL-MBIR and UL-ASIR), respectively. A lesion (pancreatic calcification) detection test was performed by two blinded radiologists with a five-point certainty level scale. Dose-length products of RDCT, LDCT, and ULDCT were 410, 97, and 36 mGy-cm, respectively. Nine patients had pancreatic calcification. The sensitivity for detecting pancreatic calcification with UL-MBIR was high (0.67–0.89) compared to L-ASIR or UL-ASIR (0.11–0.44), and a significant difference was seen between UL-MBIR and UL-ASIR for one reader (P = 0.014). The area under the receiver-operating characteristic curve for UL-MBIR (0.818–0.860) was comparable to that for L-ASIR (0.696–0.844). The specificity was lower with UL-MBIR (0.79–0.92) than with L-ASIR or UL-ASIR (0.96–0.99), and a significant difference was seen for one reader (P < 0.01). In UL-MBIR, pancreatic calcification can be detected with high sensitivity, however, we should pay attention to the slightly lower specificity

Model-based iterative reconstruction and adaptive statistical iterative reconstruction: dose-reduced CT for detecting pancreatic calcification.

Science.gov (United States)

Yasaka, Koichiro; Katsura, Masaki; Akahane, Masaaki; Sato, Jiro; Matsuda, Izuru; Ohtomo, Kuni

2016-01-01

Iterative reconstruction methods have attracted attention for reducing radiation doses in computed tomography (CT). To investigate the detectability of pancreatic calcification using dose-reduced CT reconstructed with model-based iterative construction (MBIR) and adaptive statistical iterative reconstruction (ASIR). This prospective study approved by Institutional Review Board included 85 patients (57 men, 28 women; mean age, 69.9 years; mean body weight, 61.2 kg). Unenhanced CT was performed three times with different radiation doses (reference-dose CT [RDCT], low-dose CT [LDCT], ultralow-dose CT [ULDCT]). From RDCT, LDCT, and ULDCT, images were reconstructed with filtered-back projection (R-FBP, used for establishing reference standard), ASIR (L-ASIR), and MBIR and ASIR (UL-MBIR and UL-ASIR), respectively. A lesion (pancreatic calcification) detection test was performed by two blinded radiologists with a five-point certainty level scale. Dose-length products of RDCT, LDCT, and ULDCT were 410, 97, and 36 mGy-cm, respectively. Nine patients had pancreatic calcification. The sensitivity for detecting pancreatic calcification with UL-MBIR was high (0.67-0.89) compared to L-ASIR or UL-ASIR (0.11-0.44), and a significant difference was seen between UL-MBIR and UL-ASIR for one reader (P = 0.014). The area under the receiver-operating characteristic curve for UL-MBIR (0.818-0.860) was comparable to that for L-ASIR (0.696-0.844). The specificity was lower with UL-MBIR (0.79-0.92) than with L-ASIR or UL-ASIR (0.96-0.99), and a significant difference was seen for one reader (P < 0.01). In UL-MBIR, pancreatic calcification can be detected with high sensitivity, however, we should pay attention to the slightly lower specificity.

Security from Within: Independent Review of the Washington Navy Yard Shooting

Science.gov (United States)

2013-11-01

operations such as 9/11, al Qaeda has increasingly turned to franchise operations, leveraging the individual jihad and encouraging HVEs. 199 As...the “Actuarial Versus Clinical” Assessment Debate, Psychiatric Services; 59 (2008):184-190) a relatively high number which would naturally herald...contracting personnel; assesses the suitability of foreign ownership in covered industries; tracks suspicious activity reports that may lead to

The Army War College Review. Volume 1, Number 3, August 2015. Student Publications

Science.gov (United States)

2016-03-25

particular reading of select sacred texts. In this manner, IS assumes characteristics common to “cultic” religious militant movements throughout the...essentially has a choice between either absolute anarchy or religious militancy, contemporaneously embracing the form of jihad.15 IS appeals to and...historic fundamental values, many people welcome the order, clarity, and discipline afforded by militant religious groups.19 Such an attraction

Vägivald ja propaganda

Index Scriptorium Estoniae

2006-01-01

8. IV-28. V Tallinna Kunstihoones Elin Kardi, Marco Laimre, Marko Mäetamme ja Andres Tali näitus "Vägivald ja propaganda". 26. IV-7. V näituse raames emergency biennale, rahvusvaheline rändnäitus Tšetšeenia toetuseks. 27. IV Kaasaegse Kunsti Eesti Keskuse IV ettekannete päev "Kunstniku moraalsed valikud liberaalse demokraatia ja islami kokkupõrgetes". Esinevad Margit Sutrop, Johannes Saar, Marek Järvik, Ene-Liis Semper & Eero Epner ning näitusel "Vägivald ja propaganda" osalevad kunstnikud

Sharea Issues in the Application of Takaful: Review on Islamic Law Perspective

OpenAIRE

Suharto Suharto; Muhammad Iqbal Fasa

2018-01-01

Insurance is still debated between scholars when viewed in the light of Islamic law. Contemporary Muslim jurists are fully aware that the legal status of Insurance not been determined by Islamic law thinkers in advance (jurists). The application of Takāful today is the result of a struggle between the understanding of Islami law with the reality of what happened. Thus, the problem needs to be reviewed in the light of Islamic law in depth. This paper attempts to offer Shariah Issues in the App...

78 FR 70349 - Proposed Revision of Policy for Incorporating New Test Standards Into the List of Appropriate...

Science.gov (United States)

2013-11-25

...: Particular Requirements for Electrical Heat Pumps, Air-Conditioners and Dehumidifiers. UL 60730-2-2 Automatic Electrical Controls for Household and Similar Use; Part 2 Particular Requirements for Thermal Motor Protectors. UL 60745-1 Hand-Held Motor-Operated Electric Tools--Safety--Part 1: General Requirements. UL...

Identification of structural protein-protein interactions of herpes simplex virus type 1.

Science.gov (United States)

Lee, Jin H; Vittone, Valerio; Diefenbach, Eve; Cunningham, Anthony L; Diefenbach, Russell J

2008-09-01

In this study we have defined protein-protein interactions between the structural proteins of herpes simplex virus type 1 (HSV-1) using a LexA yeast two-hybrid system. The majority of the capsid, tegument and envelope proteins of HSV-1 were screened in a matrix approach. A total of 40 binary interactions were detected including 9 out of 10 previously identified tegument-tegument interactions (Vittone, V., Diefenbach, E., Triffett, D., Douglas, M.W., Cunningham, A.L., and Diefenbach, R.J., 2005. Determination of interactions between tegument proteins of herpes simplex virus type 1. J. Virol. 79, 9566-9571). A total of 12 interactions involving the capsid protein pUL35 (VP26) and 11 interactions involving the tegument protein pUL46 (VP11/12) were identified. The most significant novel interactions detected in this study, which are likely to play a role in viral assembly, include pUL35-pUL37 (capsid-tegument), pUL46-pUL37 (tegument-tegument) and pUL49 (VP22)-pUS9 (tegument-envelope). This information will provide further insights into the pathways of HSV-1 assembly and the identified interactions are potential targets for new antiviral drugs.

Procedures involving lipid media for detection of bacterial contamination in breweries.

Science.gov (United States)

Van Vuuren, H J; Louw, H A; Loos, M A; Meisel, R

1977-02-01

The liquid equivalent of universal beer agar, designated universal beer liquid medium, and its beer-free equivalent, universal liquid medium (UL), were equally effective in demonstrating bacterial contamination in 120 of 200 samples from different stages of commercial brewing process. Growth of the contaminants after 3 days was consistently more luxuriant in the UL medium. A yeast-water substrate medium failed to reveal many contaminants detected with UL in 392 samples from three breweries and revealed only a few not detected with UL. The use of UL and a lactose-peptone medium, with microscope examination of the media for bacterial growth, permitted detection of 93% of the known contaminants compared to 87%, detected with UL alone; this combination or universal beer liquid medium plus lactose-peptone medium can therefore be recommended for the detection of bacterial contaminants in brewery samples. Bacterial contamination of pitching yeasts appeared to be a particular problem in the breweries investigated.

In Their Own Words: Voices of Jihad

Science.gov (United States)

2008-01-01

the tyranny of nature.’ The shrines of such a culture are huge factories and cinemas , chemical laboratories and dance halls and power stations. The...priests of such a worship are bankers and engineers, cinema stars and indus- trialists and aviators. The inevitable result of this state of affairs...weapon.” Based on U.S. and Japanese biological weapons programs from World War II, it showed “how to inject carrier animals, like rats, with the virus

Islam’s Challenge: Jihad and Terrorism

Science.gov (United States)

2008-12-12

themselves as the ‘Ikhwan’ or brotherhood. They, like Mohammad who had cleansed the Kaba of its idols, destroyed Sufi shrines and sacred tombs in Mecca and...Medina, including those of the Prophet and his companions. They also destroyed the tomb of Hussain at Karbala, a major Shii holy place, an act...In the Muslim Brotherhood, he quickly emerged as the most important ideologue amid the growing confrontation with the Egyptian regime (Richardson

In Their Own Words: Voices of Jihad

National Research Council Canada - National Science Library

Aaron, David

2008-01-01

... from the Qur'an, Hadith, and earlier Islamic writers and scholars. This book offers unfiltered access to a broad range of the stories, rationales, ideas, and arguments of jihadi terrorists and those who...

Jihad Bunuh Diri Menurut Hadis Nabi SAW

Directory of Open Access Journals (Sweden)

Adynata Adynata

2013-09-01

Full Text Available Pada zaman sekarang sering kita mendengar dan melihat di media massa banyaknya terjadi born bunuh diri, baik di tempat-tempat fasilitas umum seperti hotel, rumah ibadah, tempat pertemuan ataupun yang terjadi di daerah peperangan seperti di Palestina ketika perang antara tentara Israel dan Palestina. Para ulama telah mengkaji tentang hukum melakukan bom bunuh diri. Mereka berbeda pendapat tentang hukumnya; ada yang membolehkan dan ada pula yang melarang secara mutlak. Ayat-ayat al­ Quran dan hadis Rasulullah SAW yang terkait dengan persoalan ini, secara zahir tampak bertentangan. Dalam sebuah hadis Beliau melarang membunuh diri dengan cara apapun dan nanti di dalam neraka Jahannam pelakunya akan disiksa dengan cara yang dilakukannya ketika membunuh dirinya serta kekal di dalamnya. Sementara dalam Hadis yang lain disebutkan Rasulullah SAW menawarkan kepada satu orang sahabatnya untuk melawan musuh yang banyak yang diyakini akan membawa kematiannya pada perang Uhud sehingga terkesan sahabat tersebut mengorbankan dirinya. Hadis-hadis yang tampak bertentangan ini perlu dikaji lebih mendalam untuk ditemukan relevansinya dengan peristiswa born bunuh diri yang banyak terjadi sekarang. Penulis memahami bahwa bom bunuh diri pada prinsipnya diharamkan, tetapi jika dilakukan dalam kondisi terpaksa dalam medan peperangan untuk menyelamatkan pasukan dan menghindarkan bahaya yang lebih besar lagi maka boleh dilakukan asalkan atas perintah pemimpin perang. tetapi jika dilakukan tidak kondisi perang maka tidak boleh dilakukan dan termasuk sikap putus asa terhadap kemaksiatan yang terjadi

In Their Own Words: Voices of Jihad

National Research Council Canada - National Science Library

Aaron, David

2008-01-01

.... A minimum of introductory and contextual material is provided, so that the reader may experience the full impact of what they are saying to each other and to the world. It is hoped that this will provide greater insights into the motives, plans, and participants in jihadi terrorism, as well as the nature of the threat they pose.

Delegitimizing Al-Qaeda: A Jihad-Realist Approach

Science.gov (United States)

2012-03-01

Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a...unique “ brand ” of violent extremism: complex, simultaneous, multiple-target, mass casualty terrorist attacks directed at the U.S. 2 homeland.8 Short...Terror,” Studies in Conflict and Terrorism, Vol. 32, 2009, pp. 109-138; William D. Casebeer and James A Russell, “ Storytelling and Terrorism: Towards a

75 FR 77671 - Expansion of the Scope of NRTL Recognition of MET Laboratories, Inc.; Correction of the Scope of...

Science.gov (United States)

2010-12-13

... connection with this request, NRTL Program staff did not perform any on-site review of MET's recognized site... MET application are available for review by contacting the Docket Office, Occupational Safety and... and Marine Crafts UL 466 Electric Scales UL 561 Floor-Finishing Machines UL 1230 Amateur Movie Lights...

A classification of marked hijaiyah letters' pronunciation using hidden Markov model

Science.gov (United States)

Wisesty, Untari N.; Mubarok, M. Syahrul; Adiwijaya

2017-08-01

Hijaiyah letters are the letters that arrange the words in Al Qur'an consisting of 28 letters. They symbolize the consonant sounds. On the other hand, the vowel sounds are symbolized by harokat/marks. Speech recognition system is a system used to process the sound signal to be data so that it can be recognized by computer. To build the system, some stages are needed i.e characteristics/feature extraction and classification. In this research, LPC and MFCC extraction method, K-Means Quantization vector and Hidden Markov Model classification are used. The data used are the 28 letters and 6 harakat with the total class of 168. After several are testing done, it can be concluded that the system can recognize the pronunciation pattern of marked hijaiyah letter very well in the training data with its highest accuracy of 96.1% using the feature of LPC extraction and 94% using the MFCC. Meanwhile, when testing system is used, the accuracy decreases up to 41%.

Ultra Low Sulfur Home Heating Oil Demonstration Project

Energy Technology Data Exchange (ETDEWEB)

Batey, John E. [Energy Research Center, Inc., Easton, CT (United States); McDonald, Roger [Brookhaven National Lab. (BNL), Upton, NY (United States)

2015-09-30

This Ultra Low Sulfur (ULS) Home Heating Oil Demonstration Project was funded by the New York State Energy Research and Development Authority (NYSERDA) and has successfully quantified the environmental and economic benefits of switching to ULS (15 PPM sulfur) heating oil. It advances a prior field study of Low Sulfur (500 ppm sulfur) heating oil funded by NYSERDA and laboratory research conducted by Brookhaven National Laboratory (BNL) and Canadian researchers. The sulfur oxide and particulate matter (PM) emissions are greatly reduced as are boiler cleaning costs through extending cleaning intervals. Both the sulfur oxide and PM emission rates are directly related to the fuel oil sulfur content. The sulfur oxide and PM emission rates approach near-zero levels by switching heating equipment to ULS fuel oil, and these emissions become comparable to heating equipment fired by natural gas. This demonstration project included an in-depth review and analysis of service records for both the ULS and control groups to determine any difference in the service needs for the two groups. The detailed service records for both groups were collected and analyzed and the results were entered into two spreadsheets that enabled a quantitative side-by-side comparison of equipment service for the entire duration of the ULS test project. The service frequency for the ULS and control group were very similar and did indicate increased service frequency for the ULS group. In fact, the service frequency with the ULS group was slightly less (7.5 percent) than the control group. The only exception was that three burner fuel pump required replacement for the ULS group and none were required for the control group.

Optimized enzyme-linked immunosorbent assay for detecting cytomegalovirus infections during clinical trials of recombinant vaccines.

Science.gov (United States)

Pagnon, Anke; Piras, Fabienne; Gimenez-Fourage, Sophie; Dubayle, Joseline; Arnaud-Barbe, Nadège; Hessler, Catherine; Caillet, Catherine

2017-11-01

In clinical trials of cytomegalovirus (CMV) glycoprotein B (gB) vaccines, CMV infection is detected by first depleting serum of anti-gB antibodies and then measuring anti-CMV antibodies with a commercially available enzyme-linked immunosorbent assay (ELISA) kit, with confirmation of positive findings by immunoblot. Identification of CMV immunoantigens for the development of an ELISA that detects specifically CMV infection in clinical samples from individuals immunized with gB vaccines. Sensitivity and specificity of ELISAs using antigenic regions of CMV proteins UL83/pp65, UL99/pp28, UL44/pp52, UL80a/pp38, UL57, and UL32/pp150 were measured. An IgG ELISA using a UL32/pp150 [862-1048] capture peptide was the most specific (93.7%) and sensitive (96.4%) for detecting CMV-specific antibodies in sera. The ELISA successfully detected CMV-specific antibodies in 22 of 22 sera of subjects who had been vaccinated with a gB vaccine but who had later been infected with CMV. The ELISA was linear over a wide range of CMV concentrations (57-16,814 ELISA units/mL) and was reproducible as indicated by a 5% intra-day and 7% inter-day coefficients of variation. The signal was specifically competed by UL32/pp150 [862-1048] peptide but not by CMV-gB or herpes simplex virus 2 glycoprotein D. Lipid and hemoglobin matrix did not interfere with the assay. The UL32/pp150 [862-1048] IgG ELISA can be used for the sensitive and specific detection of CMV infection in gB-vaccinated individuals. Copyright © 2017 Elsevier B.V. All rights reserved.

Mengungkap Kesadaran Islami atas Riba pada Proses Pembelajaran Akuntansi

Directory of Open Access Journals (Sweden)

Virginia Nur Rahmanti

2017-08-01

Full Text Available This research aimed to know awareness of teachers (lecturers specifically on subject of Financial Accounting including recognition, measurement, and reporting of “interest”. Muslims believe that interest is forbidden as riba. Indeed, the practice of interest is not limited as Islamic issue, but it is viewed as universal issue based on housing bubble price cycle that may affect all sectors. By employing post-phenomenology as well as thought of Don Ihde, this research involving five diversified informant. The results showed that the subjects of Financial Accounting lecturer (Muslim still stuck on "technology" (term of Ihde in the form of international curriculum standards, reference books, and subject (course planning.

Etika Konsumsi Islami dari Pegawai SMU di Kota Bandung

Directory of Open Access Journals (Sweden)

Ima Amaliah

2015-06-01

Full Text Available The aim of this paper is to find out how is the Islamic consumption behavior of the employees working at the Senior High Schools in Bandung. This paper used the quantitative descriptive approach with survey method. The respondents were 100 people taken from all the employees (teachers and administration staffs working at 10 selected Senior High Schools. The result shows that there was no significant difference of the consumption behavior between the employees working at Islamic education institutions and public institutions in Bandung. In general, the Islamic consumption behavior from the employees working around Senior High Schools environment was categorized high mainly for the indicator of selecting the halal brand food, good and useful in the consumption.However, there was still the behavior directing to useless and excessive behavior caused by the effect of advertisement, discount and personal prestige. There fore,internalization of the religious values in all aspects of life as well as the improvement of knowledge in which an individual can minimize the consumptive behavior that engenders him or her as well as their whole life is considerably required

Konseling Islami Untuk Meningkatkan Efikasi Diri Pasien HIV/AIDS

Directory of Open Access Journals (Sweden)

Dina Hajja Ristianti

2018-01-01

HIV/AIDS sufferers show low self efficacy that causes hypochondria which people often think about loss, loneliness and sinful feelings above all of what has been done. This causes them less emphasis on health care. Implementation of the value of Islamic religion in counseling or called Islamic counseling is very important to do because of a strong relationship between religious Islam with increase self-efficacy. This study wanted to know how self efficacy of HIV/AIDS sufferers in Rejang Lebong Regency can be improved by Islamic counseling. This research was conducted in clinic VCT RSUD Curup Rejang Lebong with the counselor as the key informant.Triangulasi is done by interviewing doctor hwo is handling patient and also companion of peer (PS. Data collection is done by interview and documentation. Futuremore the data is analyzed by doing data reduction, data presentation and conclusion and meaning. The result of research shows that Islamic Counseling is done by counselor on post test counseling by giving advice concerning Allah's greatness, His forgiveness and taubatan nashuhah that bring the patient becomes more resilient, anthusiastict with the process of treatment, more eager to fulfill worship and dayly activity.

Efektivitas Prinsip Dan Implementasi Islami Pendidikan Karakter di Keluarga

Directory of Open Access Journals (Sweden)

Moh. Hasyim Afandi

2017-09-01

Full Text Available Education is the key in forming the character of children early on, because the essence of education is not just limited to transfer of knowledge but also to transfer of values, all of those are done to build the character of the nation's noble personality and cope with juvenile delinquency from various social deviations. Character education has been the National Action Plan since May 2nd, 2010 by Muh. Nuh as Education Minister of Indonesia. The draft sets the year 2010-2014 as consolidation and the placement of the foundation. Then in 2015-2019 as a consolidation strategy implementation and continued in 2020-2024 as a sustainable development. There are many factors that cause the importance of Indonesian society to work together to succeed the character education in Indonesia. Schools have a strategic role in value education, the reality shows that schools cannot do it alone. Apparently, the family has a big enough role. Family is the first moral educator for children. Their parents were the first moral teachers and directly influential element. Whereas, teachers at school can change at any time. Parent-child relationships are built upon a very meaningful emotional foundation that allows a child to feel loved and valuable or unloved and worthless. If the individual character is based on religious values as the foundation/main base, then will be born the soul of strong character and become strong nation shoots anyway. The main goal of character education according to Islam is to form the personality of learners so having ethics, and a good sense of culture and make it happen in everyday life.

Anicteric hepatoxicity: a potential health risk of occupational exposures in Nigerian petroleum oil refining and distribution industry.

Science.gov (United States)

Ezejiofor, Tobias I Ndubuisi; Ezejiofor, Anthonet N; Orisakwe, Orish E; Nwigwe, Hariet C; Osuala, Ferdinand Ou; Iwuala, Moses Oe

2014-01-22

Literature abounds linking one's job to certain unpalatable health outcomes. Since exposures to hazardous conditions in industrial environments often results in sundry health effects among workers, we embarked on this study to investigate the hepatic health effects of occupational activities in the petroleum refining and distribution industry. Biochemical markers of liver functions were assayed in plasma, using Reflotron dry chemistry spectrophotometric system. The study was conducted on randomly selected workers of Port Harcourt Refining Company (PHRC) and Pipelines and Petroleum Product Marketing Company (PPMC) both in Alesa-Eleme near Port Harcourt, Nigeria, as well as non-oil work civil servants serving as control subjects. Results showed that, bilirubin ranged 0.3-1.6 mg/dl with a mean of 0.66±0.20mg/dl among the oil workers as against 0.5-1.00mg/dl with a mean of 0.58±0.13mg/dl in non-oil workers, Alkaline phosphatase ranged 50.00-296.00u/l (mean: 126.21±39.49u/l) in oil workers as against 40.20-111u/l (mean: 66.83±18.54u/l) for non-oil workers, Aspartic transaminases (AST) ranged 5.80-140.20u/l (mean: 21.81±11.49u/l) in oil workers against 18.00-44.00u/l (mean: 26.89±6.99u/l) for non-oil workers, while Alanine transaminases (ALT) ranged 4.90-86.00u/l (mean: 22.14±11.28u/l) in oil workers as against 10.00-86.60u/l (mean: 22.30±10.22u/l) for the non-oil workers. A close study of the results revealed that although the mean values for all the studied parameters were still within the parametric reference ranges, however, relative to the referents, there were significant increases (Pdifferentiation data showed that though the mean values for the parameters were higher in males than females, the increases were not significant in most cases (P>0.05), whereas data for age and exposure period classifications revealed that irrespective of the age of the worker, the effects are likely to start after the first five years, manifesting fully after the first decade

Sensor for volatile organic compounds using an interdigitated gold electrode modified with a nanocomposite made from poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) and ultra-large graphene oxide

International Nuclear Information System (INIS)

Hasani, Amirhossein; Salehi, Alireza; Dehsari, Hamed Sharifi; Gavgani, Jaber Nasrollah; Shalamzari, Elham Khodabakhshi; Taromi, Farmarz Afshar; Mahyari, Mojtaba

2015-01-01

A highly efficient gas sensor is described based on the use of a nanocomposite fabricated from poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT-PSS) and ultra-large graphene oxide (UL-GO). The nanocomposite was placed by drop casting in high uniformity on interdigitated gold electrodes over a large area of silicon substrate and investigated for its response to volatile organic compounds (VOCs) at room temperature. Monolayers of UL-GOs were synthesized based on a novel solution-phase method involving pre-exfoliation of graphite flakes. The nanocomposite was optimized in terms of composition, and the resulting vapor sensor (containing 0.04 wt% of UL-GO) exhibits strong response to various VOC vapors. The improved gas-sensing performance is attributed to several effects, viz. (a) an enhanced transport of charge carriers, probably a result of the weakening of columbic attraction between PEDOT and PSS by the functional groups on the UL-GO sheets; (b) the increase in the specific surface area on adding UL-GO sheets; and (c) enhanced interactions between the sensing film and VOC molecules via the network of π-electrons. The sensitivity, response and recovery times of the PEDOT-PSS/UL-GO nanocomposite gas sensor with 0.04 wt% of UL-GO are 11.3 %, 3.2 s, and 16 s, respectively. At a methanol vapor concentration as low as 35 ppm, this is an improvement by factors of 110, 10, and 6 respectively, compared to a PEDOT-PSS reference gas sensor without UL-GO. (author)

Does provision of extrinsic feedback result in improved motor learning in the upper limb poststroke? A systematic review of the evidence.

Science.gov (United States)

Subramanian, Sandeep K; Massie, Crystal L; Malcolm, Matthew P; Levin, Mindy F

2010-02-01

Recovery of the upper limb (UL) after a stroke occurs well into the chronic stage. Stroke survivors can benefit from adaptive plasticity to improve UL movement through motor relearning. The provision of feedback has been shown to decrease the use of compensatory UL movement patterns. However, the effectiveness of feedback in improving UL motor recovery after a stroke has not yet been systematically reviewed. The objective of this review was to systematically examine the role of extrinsic feedback on implicit motor learning after stroke, focusing on UL movement and functional recovery. The authors retrieved 9 studies that examined the role of feedback on UL motor recovery. Of these, 6 were randomized controlled trials (RCTs), 1 was a single-subject design, 1 was a pre-post design, and 1 was a cohort study. The studies were rated on the basis of Sackett's levels of evidence and PEDro (Physiotherapy Evidence Database) scores for RCTs. Levels of evidence were limited (level 2b) for UL motor learning of the less-affected extremity and strong (level 1a) for the more-affected extremity. The results suggest that people with stroke may be capable of using extrinsic feedback for implicit motor learning and improving UL motor recovery. Emergent questions regarding the advantages of using different media for feedback delivery and the optimal type and schedule of feedback to enhance motor learning in patient populations still need to be addressed.

Avaliação dos níveis das transaminases dos pacientes com infecção pelo Plasmodium vivax atendidos em um centro de referência para tratamento da malária no Estado de Mato Grosso

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Elisane de Freitas Pereira

2017-11-01

Full Text Available Objetivo: Analisar os marcadores hepáticos (transaminases em pacientes com malária causada pelo Plasmodium vivax. Métodos: Trata-se de um estudo transversal retrospectivo, incluindo pacientes que apresentaram monoinfecção pelo P. vivax. O teste de Mann-Whitney U ou o teste t de Student foram utilizados para comparar a atividade média das transaminases de acordo com a classificação clínica e epidemiológica do paciente infectado. O teste de Kruskal-Wallis foi utilizado para comparar a média da atividade das transaminases de acordo com a classificação da infecção. Valores de p<0,05 foram considerados significativos. Resultados: Indivíduos menores de 7 anos apresentaram maior atividade da transaminase glutâmico oxalacética (TGO e da transaminase glutâmico pirúvica (TGP — respectivamente, 68,7 U/L e 79,8 U/L — em relação a pacientes com idade de 8 a 59 anos (TGO 29,8 U/L e TGP 39,2 U/L e acima de 60 anos (TGO 32,5 U/L e TGP 34 U/L. A média da dosagem sérica de TGO de todos os pacientes incluídos no estudo foi de 31,99 U/L e de TGP foi de 41,1 U/L. A atividade de TGP nos pacientes primoinfectados foi maior que nos reinfectados ou com recaída, sendo 65,6 U/L contra 36,2 U/L e 32,7 U/L, respectivamente. Conclusão: Crianças apresentam maior atividade de transaminases que os indivíduos maiores de sete anos de idade. Pacientes com infecção prévia pelo P. vivax apresentam menores valores séricos da atividade das transaminases do que os primoinfectados. Indivíduos com episódios de recaída apresentam menores valores das enzimas avaliadas do que aqueles com reinfecção ou primoinfecção.

CTC Sentinel. Volume 1, Issue 1, December 2007. West Point Releases First Issue of CTC Sentinel

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2007-12-01

ideologues themselves. A common categorization of Salafism is Quintan Wiktorowicz’s typology that divides Salafism into three currents: purists...implemented.4 While a useful starting point, the typology provides 2 For his biography, see Brynjar Lia, Architect of Global Jihad: The Life of...Sayyid Imam, in judging whether or not to employ violence, particularly against an Islamic government or foreign tourists , one must always consider

Kazakhstan: Recent Developments and U.S. Interests

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2013-07-22

Coalition to back him. Many oppositionists supported a Movement for a Just Kazakhstan, which backed Zharmakhan Tuyakbay, the head of the Social Democratic...members of the obscure Islamic Jihad Group/Union of Uzbekistan (reportedly an offshoot of the Islamic Movement of Uzbekistan). It alleged that the...against women and discrimination against non- ethnic Kazakhs in government, persons with disabilities, and those in the LGBT community were problems

Veiled Bombshells: Women’s Participation in Islamist Extremist Organizations

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2017-06-01

sphere. Women routinely marched alongside and in front of the men, often physically protecting them from British authorities who were hesitant to... Women Seek Bigger Political Role,” Washington Post, 24 November 2006, http://www.washingtonpost.com/wp-dyn/content/article/2006/11/24...an-imperative-for- women -too-1.110997. 79 Alexander Meleagrou-Hitchens, “The Female Jihad,” Gatestone Institute, 10 March 2010, https

Have Changes to Unused Land in China Improved or Exacerbated Its Environmental Quality in the Past Three Decades?

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Ling Yi

2016-02-01

Full Text Available Inappropriate land use has caused a series of environmental disasters such as floods and sand storms, and some of them involved unused land changes with highly localized distributions in arid and semi-arid regions with fragile ecosystems. As the third-rank category of first-level land use/cover in China, unused land (UL is now playing an increasingly important role in protection of the natural environment and sustainable utilization of land resources. In this article, we assessed the effects on regional eco-environments employing a quantitative EL (ecological effect index model, which can be used to evaluate and represent the contribution of UL changes to the eco-environmental quality. Results show that UL changes generally contributed to the deterioration of eco-environmental quality during the study period. Some major contributors to improving eco-environmental quality were transformation of sandy land and saline-alkali lands to grasslands, expansion of water bodies in UL areas, and reclamation of farmland in UL areas (except for marsh lands. In contrast, the main contributors to worsening eco-environmental quality were grassland degradation to UL (except marshes, reclamation of marsh areas, and shrinkage of water bodies to leave desert or saline-alkali land. Some suggestions are provided about UL management, utilization, and protection issues.

Review of underground logistic systems in the Netherlands : An ex-post evaluation of barriers, enablers and spin-offs

NARCIS (Netherlands)

Wiegmans, B.W.; Visser, J.; Konings, R.; Pielage, B.J.A.

2010-01-01

Now, 10 years after the first plans, we analyse in this paper what has happened with Underground Logistic Systems (ULS). The major question in this paper is: Which barriers and enablers led to the failure of ULS and what ULS spin-offs can be found nowadays? Several factors can be classified as

Cell-cycle-dependent localization of human cytomegalovirus UL83 phosphoprotein in the nucleolus and modulation of viral gene expression in human embryo fibroblasts in vitro.

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Arcangeletti, Maria-Cristina; Rodighiero, Isabella; Mirandola, Prisco; De Conto, Flora; Covan, Silvia; Germini, Diego; Razin, Sergey; Dettori, Giuseppe; Chezzi, Carlo

2011-01-01

The nucleolus is a multifunctional nuclear compartment widely known to be involved in several cellular processes, including mRNA maturation and shuttling to cytoplasmic sites, control of the cell cycle, cell proliferation, and apoptosis; thus, it is logical that many viruses, including herpesvirus, target the nucleolus in order to exploit at least one of the above-mentioned functions. Recent studies from our group demonstrated the early accumulation of the incoming ppUL83 (pp65), the major tegument protein of human cytomegalovirus (HCMV), in the nucleolus. The obtained results also suggested that a functional relationship might exist between the nucleolar localization of pp65, rRNA synthesis, and the development of the lytic program of viral gene expression. Here we present new data which support the hypothesis of a potentially relevant role of HCMV pp65 and its nucleolar localization for the control of the cell cycle by HCMV (arrest of cell proliferation in G1-G1/S), and for the promotion of viral infection. We demonstrated that, although the incoming pp65 amount in the infected cells appears to be constant irrespective of the cell-cycle phase, its nucleolar accumulation is prominent in G1 and G1/S, but very poor in S or G2/M. This correlates with the observation that only cells in G1 and G1/S support an efficient development of the HCMV lytic cycle. We propose that HCMV pp65 might be involved in regulatory/signaling pathways related to nucleolar functions, such as the cell-cycle control. Co-immunoprecipitation experiments have permitted to identify nucleolin as one of the nucleolar partners of pp65.

Patients with Duchenne and Becker muscular dystrophies are not more asymmetrical than healthy controls on timed performance of upper limb tasks

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M.C. Artilheiro

Full Text Available This study aimed to investigate possible asymmetries and relationships between performance of dominant and non-dominant upper limbs (UL in patients with Duchenne and Becker muscular dystrophies (DMD/BMD, to compare UL performance of patients and healthy subjects and to investigate the relationship between timed performance of UL and age, motor function and muscle strength in DMD/BMD patients. Sixteen patients with DMD and 3 with BMD were evaluated with Jebsen-Taylor Test (timed performance, Vignos scale and Dimension 3 of Motor Function Measure (motor function, and Medical Research Council scale (muscle strength on a single session. ANOVA showed no asymmetry between dominant and non-dominant UL, except in the writing subtest, in patients and in healthy controls. There were relationships between dominant and non-dominant UL performances. Correlations between timed performance, motor function and muscle strength were found, but age was not correlated with these variables. These findings may reduce the assessment time, prevent fatigue and provide more accurate clinical reasoning involving UL in DMD/BMD treatment.

An augmented reality system for upper-limb post-stroke motor rehabilitation: a feasibility study.

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Assis, Gilda Aparecida de; Corrêa, Ana Grasielle Dionísio; Martins, Maria Bernardete Rodrigues; Pedrozo, Wendel Goes; Lopes, Roseli de Deus

2016-08-01

To determine the clinical feasibility of a system based on augmented reality for upper-limb (UL) motor rehabilitation of stroke participants. A physiotherapist instructed the participants to accomplish tasks in augmented reality environment, where they could see themselves and their surroundings, as in a mirror. Two case studies were conducted. Participants were evaluated pre- and post-intervention. The first study evaluated the UL motor function using Fugl-Meyer scale. Data were compared using non-parametric sign tests and effect size. The second study used the gain of motion range of shoulder flexion and abduction assessed by computerized biophotogrammetry. At a significance level of 5%, Fugl-Meyer scores suggested a trend for greater UL motor improvement in the augmented reality group than in the other. Moreover, effect size value 0.86 suggested high practical significance for UL motor rehabilitation using the augmented reality system. System provided promising results for UL motor rehabilitation, since enhancements have been observed in the shoulder range of motion and speed. Implications for Rehabilitation Gain of range of motion of flexion and abduction of the shoulder of post-stroke patients can be achieved through an augmented reality system containing exercises to promote the mental practice. NeuroR system provides a mental practice method combined with visual feedback for motor rehabilitation of chronic stroke patients, giving the illusion of injured upper-limb (UL) movements while the affected UL is resting. Its application is feasible and safe. This system can be used to improve UL rehabilitation, an additional treatment past the traditional period of the stroke patient hospitalization and rehabilitation.

Genotypic diversity and mixed infection in newborn disease and hearing loss in congenital cytomegalovirus infection.

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Pati, Sunil K; Pinninti, Swetha; Novak, Zdenek; Chowdhury, Nazma; Patro, Raj K; Fowler, Karen; Ross, Shannon; Boppana, Suresh

2013-10-01

Congenital cytomegalovirus (cCMV) is a common congenital infection and a leading nongenetic cause of sensorineural hearing loss (SNHL). CMV exhibits extensive genetic variability, and infection with multiple CMV strains (mixed infection) was shown to be common in congenital CMV. The role of mixed infections in disease and outcome remains to be defined. Genotyping of envelope glycoproteins, UL55 (gB), UL73 (gN) and UL75 (gH), was performed on saliva specimens of 79 infants from the ongoing CMV and Hearing Multicenter Screening (CHIMES) Study and on blood and urine specimens of 52 infants who participated in natural history studies at the University of Alabama at Birmingham. Genotyping of UL144 and US28 was also performed in the CHIMES cohort. The association of individual genotypes and mixed infection with clinical findings at birth and SNHL was examined. Thirty-seven of 131 infants (28%) were symptomatic at birth and 26 (20%) had SNHL at birth. All known genotypes of UL55, UL75, UL73 and US28 were represented, and no particular genotype was associated with symptomatic infection or SNHL. UL144 subtype C was more common in symptomatic infants but not associated with SNHL. Mixed infection was observed in 59 infants (45%) and not associated with symptoms (P = 0.43) or SNHL at birth (P = 0.82). In the cohort of 52 infants with long-term hearing outcome, mixed infection at birth was not predictive of SNHL. Mixed infection is common in infants with congenital CMV but is neither associated with symptomatic infection nor associated with SNHL.

Burkitt's lymphoma causing acute pancreatitis in a child

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Muhammed Akıl

2013-01-01

Full Text Available A 8-year-old boy admitted with abdominal pain, fever and vomiting for the previous 10 days. Sensitivity was detected in the epigastric area. There was not defense and rebond. Aspartate aminotransferase was 106 U/L, alanine aminotransferase 25 U/L, alkaline phosphatase 311 U/L, blood amylase level 748 U/L, blood lipase level 391 U/L. In thoracic CT, soft tissue with smooth contours measuring 32 mm×28 mm was identified in the posterior mediastinum. Bone marrow aspiration biopsy was normal. A mass specimen obtained from the duodenum endoscopic biopsy. This specimen was diffuse staining by leukocyte common antigen, CD10 and CD20. The patient was diagnosed with acute pancreatitis associated with stage 3 duodenal Burkitt's lymphoma. Modified LMB-98 was initiated. Burkitt's lymphoma may rarely cause acute pancreatitis.

Analgesic and anti-inflammatory actions on bradykinin route of a polysulfated fraction from alga Ulva lactuca.

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de Araújo, Ianna Wivianne Fernandes; Rodrigues, José Ariévilo Gurgel; Quinderé, Ana Luíza Gomes; Silva, Jane de Fátima Teixeira; Maciel, Gabrielle de Freitas; Ribeiro, Natássia Albuquerque; de Sousa Oliveira Vanderlei, Edfranck; Ribeiro, Kátia Alves; Chaves, Hellíada Vasconcelos; Pereira, Karuza Maria Alves; Bezerra, Mirna Marques; Benevides, Norma Maria Barros

2016-11-01

We investigated structural features of polysaccharides from Ulva lactuca and their effects on the classical models of nociception and inflammation. Crude extract was obtained by enzymatic digestion and isolated by ion exchange chromatography on DEAE-cellulose. The fraction with higher yield was used in the tests (SP-Ul). Swiss mice received SP-Ul (1, 3 or 9mg/kg; i.v.), 30min prior to injection of 0.8%-acetic acid or 1%-formalin or prior to a thermal stimulus. At same doses, SP-Ul was tested on Wistar rats on paw edema elicited by different irritants (carrageenan, dextran, bradykinin, histamine or serotonin). The results of infrared characterization indicated the presence of hydroxyl groups, sulfate, uronic acid and glycosidic linkages in all SP fractions spectrums. SP-Ul decreased significantly the antinociception in response to acetic acid or formalin (second phase), but not in the hot-plate test, suggesting that its analgesia occurs through a peripheral mechanism. SP-Ul did not reduce carrageenan-induced paw edema as supported by both histological and myeloperoxidase activity assessments. However, SP-Ul (1mg/kg; s.c.) reduced dextran-elicited edema, showing vascular anti-inflammatory effect, with bradykinin as major target because it did not reduce histamine- and serotonin-induced paw edemas. Therefore, SP-Ul acts on bradykinin pathway in its antinociceptive and anti-inflammatory responses. Copyright © 2016 Elsevier B.V. All rights reserved.

The Tūqmāq and the Ming China: The Tūqmāq and the Chinese Relations during the Ming Period (1394–1456

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Kenzheakhmet N.

2017-12-01

Full Text Available Objective: Little is known about diplomatic relations between the Jūchīd Ulūs and Ming China (1368–1644, even though some evidence of early tributary trade relations exists. The first extant Chinese account about the country of Salai (Saray dates to around 1394, when accounts of diplomatic exchange between the Ming court and the Jūchīd Ulūs began to appear in the Ming shilu (The Veritable Records of the Ming. Research materials: This article analyzes the Ming shilu in order to understand the character of Chinese knowledge about the Jūchīd Ulūs during their years of contact between 1394 and 1456. Additional sources like geographic accounts and maps help define the extent of Chinese knowledge about the khanate, clarify the kinds of information that the Chinese sought and the reasons why, and measure the influence of cross-cultural contact on Ming Chinese understanding of the Jūchīd Ulūs. Results and novelty of the research: The Ming shilu suggests that at least by the end of the fourteenth and the early years of the fifteenth century, Salai (Saray became an integral, and possibly the most important, element in the name that the Ming court used for the country of the Jūchīd Ulūs. The Persian and Mongol historians used the term Tūqmāq and Togmog to refer to the Jūchīd Ulūs, while Ming Chinese historians used the term Tuohema to refer to the Jūchīd Ulūs or the whole Dasht-i Qipchāq, in post-Mongol Central Eurasia. The diplomatic contact between Ming China and the Tuohuma occurred through the Chinese system of tribute trade during the mid-fifteenth century. Under the reign of Yongle (1402–1424, Zhengtong (1435–1449, and Jingtai (1449–1457, the foundations for a flourishing relationship between Ming China and the Jūchīd Ulūs were established. At that time, the Chinese knew the Jūchīd Ulūs by the name Salai (Saray and Tuohuma (Tūqmāq. Despite the political turmoil that erupted after the fall of the Jūchīd Ul

CTC Sentinel. Volume 6, Issue 3

Science.gov (United States)

2013-03-01

century mausoleums and shrines, including the tombs of Sidi Mahmoud, Sidi Moctar, and Alpha Moya in Timbuktu. The shrines are part of the UNESCO...them: Makhtab-al-Khidamat, the al-Haramain Foundation, the Armed Islamic Group, Egyptian Islamic Jihad, Jemaah Islamiya, al-Gama`a al-Islamiyya...religion. Yet during Maumoon Abdul Gayoom’s three- decade autocratic rule, the Egyptian - trained religious scholar enacted a number of measures that

An Assessment of the Global War on Terrorism, 2001-2010

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2010-12-01

60 Lianne Boudali, “The GSPC: Newest Franchise in Al-Qa’ida’s Global Jihad,” West Point: Combating Terrorism Center, 2007, 8, http...Zaitouni, liquidated the group. At their internal front, in July 1995 the LIFG had to prematurely leave the underground preparation phase and declare...their disputes with the liquidation of their rivals and rose to leadership positions through oppression, betrayal, and murder. Al-mukadam argues

Beyond al-Qaeda. Part 1. The Global Jihadist Movement

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2006-01-01

the Tokyo subway in March 1995, was able to fashion a crude chemical weapon, but failed to fabricate a biological device, despite substantial...in Morocco, terrorist lead- ers with al-Qaeda connections who trained in Afghanistan were the organizers. One major change in these “ franchised ...from Eurasia. Hamas and its offshoot, the Palestinian Islamic Jihad (PIJ), provided shelter, food , and training. From Saudi Arabia and Yemen, Saudi

Hezbollah’s Passport: Religion, Culture, and the Lebanese Diaspora

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2015-05-23

the physical needs of its Shi’ a constituency. 26 Hezbollah evolved into more than a terrorist outfit when it began building hospitals and schools in...present. The practice ofzakat­ charity -and jihad-struggle-are deeply rooted in the traditions and practices of Islam. These 48 Mul)ammad I:Iusayn...with them characteristics that encouraged communal involvement based around Islamic concepts of charity and identity. The diaspora communities in

NATO’s Small States: Albania as a Case Study

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2016-12-01

2016-11- eng.pdf#page=2. 2-5. 38 experienced a major domestic crisis in 1997 as a result of financial mismanagement and corruption through pyramid ...schemes that involved elected leaders across the country. The pyramid schemes reached all economic levels within Albania. Life savings were lost as...of several hundred individuals from Algeria, Egypt , Pakistan, and Saudi Arabia and elsewhere, including veterans of Afghan jihad, into the western

Phosphorus losses from agricultural watersheds in the Mississippi Delta.

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Yuan, Yongping; Locke, Martin A; Bingner, Ronald L; Rebich, Richard A

2013-01-30

Phosphorus (P) loss from agricultural fields is of environmental concern because of its potential impact on water quality in streams and lakes. The Mississippi Delta has long been known for its fish productivity and recreational value, but high levels of P in fresh water can lead to algal blooms that have many detrimental effects on natural ecosystems. Algal blooms interfere with recreational and aesthetic water use. However, few studies have evaluated P losses from agricultural watersheds in the Mississippi Delta. To better understand the processes influencing P loss, rainfall, surface runoff, sediment, ortho-P (orthophosphate, PO(4)-P), and total P (TP) were measured (water years 1996-2000) for two subwatersheds (UL1 and UL2) of the Deep Hollow Lake Watershed and one subwatershed of the Beasley Lake Watershed (BL3) primarily in cotton production in the Mississippi Delta. Ortho-P concentrations ranged from 0.01 to 1.0 mg/L with a mean of 0.17 mg/L at UL1 (17.0 ha), 0.36 mg/L at UL2 (11.2 ha) and 0.12 mg/L at BL3 (7.2 ha). The TP concentrations ranged from 0.14 to 7.9 mg/L with a mean of 0.96 mg/L at UL1, 1.1 mg/L at UL2 and 1.29 mg/L at BL3. Among the three sites, UL1 and UL2 received P application in October 1998, and BL3 received P applications in the spring of 1998 and 1999. At UL1, ortho-P concentrations were 0.36, 0.25 and 0.16 for the first, second and third rainfall events after P application, respectively; At UL2, ortho-P concentrations were 1.0, 0.66 and 0.65 for the first, second and third rainfall events after P application, respectively; and at BL3, ortho-P concentrations were 0.11, 0.22 and 0.09 for the first, second and third rainfall events after P application, respectively. P fertilizer application did influence P losses, but high P concentrations observed in surface runoff were not always a direct result of P fertilizer application or high rainfall. Application of P in the fall (UL1 and UL2) resulted in more ortho-P losses, likely

CYTOKINE EXPRESSION PROFILES OF PERITONEAL FLUID IN THE PATIENTS WITH UTERINE LEIOMYOMA

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K. A. Syssoev

2006-01-01

Full Text Available Abstract. Uterine leiomyoma (UL is a hormone-dependent benign tumor of uterus. Social significance of UL is stipulated by its high rate among fertile females. Scarce data exist about the impact of cytokines in UL progression. Th1/Th2 paradigm is one of crucial points in modern immunology. Evaluation of cytokines involved into either type of immune response is of special significance for studying the diseases accompanied by the changes of extracellular matrix, e.g., leiomyomas. In present study, we analyzed peritoneal fluids from UL patients, with multiplex detection of IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, GM-CSF, IFN-γ and TNF-α (Th1/Th2 panel, by means of a Bio-Plex® instrument (Bio-Rad, USA. Twenty-seven patients were observed in our study (20 patients with UL, and 7 myoma-free women (a group of comparison. The mean age of the patients was 43.5±0.6 years. The duration of UL ranged from 0 to 18 years. As a result, the levels of IL-10, GM-CSF, IFN-γ and TNF-α in patients with long-existing UL (over 5 years were significantly higher (p<0,05 than in group with a disease story of <5 years. IFN-γ values in peritoneal fluid patients with UL did inversely correlate with uterine size. Moreover, the levels of IFN-γ in patients with smaller uterine volume (<8 weeks of pregnancy were increased in relation to the group with larger tumor size. IL-10 contents were increased in the patients with adenomyosis, rapid and slow growth of UL, and in both types of tumor (simple and proliferative. Increased IL-5 levels were observed in the patients with single tumor nodules (as related to the patients bearing multiple nodes, and comparison group. Furthermore, intramural and subserosal location of nodes was characterized by increased levels of IL-5. In the patients free of adenomyosis, IL-5 value was increased against the comparison group. The changes in IL-2, IL-4, IL-12 and IL-13 levels in patients with UL were not statistically significant.

An integrative genomic and transcriptomic analysis reveals potential targets associated with cell proliferation in uterine leiomyomas.

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Priscila Daniele Ramos Cirilo

Full Text Available Uterine Leiomyomas (ULs are the most common benign tumours affecting women of reproductive age. ULs represent a major problem in public health, as they are the main indication for hysterectomy. Approximately 40-50% of ULs have non-random cytogenetic abnormalities, and half of ULs may have copy number alterations (CNAs. Gene expression microarrays studies have demonstrated that cell proliferation genes act in response to growth factors and steroids. However, only a few genes mapping to CNAs regions were found to be associated with ULs.We applied an integrative analysis using genomic and transcriptomic data to identify the pathways and molecular markers associated with ULs. Fifty-one fresh frozen specimens were evaluated by array CGH (JISTIC and gene expression microarrays (SAM. The CONEXIC algorithm was applied to integrate the data.The integrated analysis identified the top 30 significant genes (P<0.01, which comprised genes associated with cancer, whereas the protein-protein interaction analysis indicated a strong association between FANCA and BRCA1. Functional in silico analysis revealed target molecules for drugs involved in cell proliferation, including FGFR1 and IGFBP5. Transcriptional and protein analyses showed that FGFR1 (P = 0.006 and P<0.01, respectively and IGFBP5 (P = 0.0002 and P = 0.006, respectively were up-regulated in the tumours when compared with the adjacent normal myometrium.The integrative genomic and transcriptomic approach indicated that FGFR1 and IGFBP5 amplification, as well as the consequent up-regulation of the protein products, plays an important role in the aetiology of ULs and thus provides data for potential drug therapies development to target genes associated with cellular proliferation in ULs.

Prevalence and clinical significance of mediator complex subunit 12 mutations in 362 Han Chinese samples with uterine leiomyoma.

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Wu, Juan; Zou, Yang; Luo, Yong; Guo, Jiu-Bai; Liu, Fa-Ying; Zhou, Jiang-Yan; Zhang, Zi-Yu; Wan, Lei; Huang, Ou-Ping

2017-07-01

Uterine leiomyomas (ULs) are the most common gynecological benign tumors originating from the myometrium. Prevalent mutations in the mediator complex subunit 12 (MED12) gene have been identified in ULs, and functional evidence has revealed that these mutations may promote the development of ULs. However, whether MED12 mutations are associated with certain clinical characteristics in ULs remains largely unknown. In the present study, the potential mutations of MED12 and its paralogous gene, mediator complex subunit 12-like (MED12L), were screened in 362 UL tumors from Han Chinese patients. A total of 158 out of 362 UL tumors (43.6%) were identified as harboring MED12 somatic mutations, and the majority of these mutations were restricted to the 44th residue. MED12 mutations were also observed in 2 out of 145 (1.4%) adjacent control myometrium. Furthermore, the mutation spectrum of MED12 in the concurrent leiomyomas was noticeably different. Correlation analysis of MED12 mutations with the available clinical features indicated that patients with mutated MED12 tended to have smaller cervical diameters. By contrast, no MED12L mutation was identified in the present samples. In summary, the present study demonstrated the presence of prevalent MED12 somatic mutations in UL samples, and the MED12 mutation was associated with smaller cervical diameters. The low mutation frequency of MED12 in adjacent control myometrium indicated that MED12 mutation may be an early event in the pathogenesis of ULs. Furthermore, MED12 mutation status in concurrent tumors from multiple leiomyomas supported several prior observations that the majority of these tumors arose independently.

75 FR 77002 - Expansion of the Scope of NRTL Recognition of Underwriters Laboratories Inc.; Modification to the...

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2010-12-10

...): IEEE C37.20.4 Indoor AC Switches (1 kV-38 kV) for Use in Metal-Enclosed Switchgear \\a\\ IEEE C37.20.6 4.76 kV to 38 kV Rated Grounding and Testing Devices Used in Enclosures \\a\\ IEEE C37.23 Metal-Enclosed... Sprinkler Pipe for Fire Protection Service UL 962 Household and Commercial Furnishings \\c\\ UL 1340 Hoists UL...

The Use of Artificial Neural Networks in Prediction of Congenital CMV Outcome from Sequence Data

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Ravit Arav-Boger

2008-01-01

Full Text Available A large number of CMV strains has been reported to circulate in the human population, and the biological significance of these strains is currently an active area of research. The analysis of complex genetic information may be limited using conventional phylogenetic techniques. We constructed artificial neural networks to determine their feasibility in predicting the outcome of congenital CMV disease (defined as presence of CMV symptoms at birth based on two data sets: 54 sequences of CMV gene UL144 obtained from 54 amniotic fluids of women who contracted acute CMV infection during their pregnancy, and 80 sequences of 4 genes (US28, UL144, UL146 and UL147 obtained from urine, saliva or blood of 20 congenitally infected infants that displayed different outcomes at birth. When data from all four genes was used in the 20-infants’ set, the artificial neural network model accurately identified outcome in 90% of cases. While US28 and UL147 had low yield in predicting outcome, UL144 and UL146 predicted outcome in 80% and 85% respectively when used separately. The model identified specific nucleotide positions that were highly relevant to prediction of outcome. The artificial neural network classified genotypes in agreement with classic phylogenetic analysis. We suggest that artificial neural networks can accurately and efficiently analyze sequences obtained from larger cohorts to determine specific outcomes.The ANN training and analysis code is commercially available from Optimal Neural Informatics (Pikesville, MD.

Cell cultures in uterine leiomyomas: rapid disappearance of cells carrying MED12 mutations.

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Nadine Markowski, Dominique; Tadayyon, Mahboobeh; Bartnitzke, Sabine; Belge, Gazanfer; Maria Helmke, Burkhard; Bullerdiek, Jörn

2014-04-01

Uterine leiomyomas (UL) are the most frequent symptomatic human tumors. Nevertheless, their molecular pathogenesis is not yet fully understood. To learn more about the biology of these common neoplasms and their response to treatment, cell cultures derived from UL are a frequently used model system, but until recently appropriate genetic markers confirming their origin from the tumor cell population were lacking for most UL, i.e., those not displaying karyotypic abnormalities. The identification of MED12 mutations in the majority of UL makes it possible to trace the tumor cell population during in vitro passaging in the absence of cytogenetic abnormalities. The present study is addressing the in vitro survival of cells carrying MED12 mutations and its association with karyotypic alterations. The results challenge numerous in vitro studies into the biology and behavior of leiomyomas. Cells of one genetic subtype of UL, i.e., those with rearrangements of the high mobility AT-hook 2 protein gene (HMGA2), seem to be able to proliferate in vitro for many passages whereas tumor cells from the much more frequent MED12-mutated lesions barely survive even the first passages. Apparently, for the most frequent type of human UL no good in vitro model seems to exist because cells do not survive culturing. On the other hand, this inability may point to an Achilles' heel of this type of UL. Copyright © 2014 Wiley Periodicals, Inc.

Cycle of Bad Governance and Corruption

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Mohammed Nuruddeen Suleiman

2015-03-01

Full Text Available This article argues that bad governance and corruption particularly in the Northern part of Nigeria have been responsible for the persistent rise in the activities of Jama’atu Ahlis Sunna Lidda’awati wal-Jihad (JASLWJ, Arabic for “people committed to the propagation of the tradition and jihad.” It is also known as “Boko Haram,” commonly translated as “Western education is sin.” Based on qualitative data obtained through interviews with Nigerians, this article explicates how poor governance in the country has created a vicious cycle of corruption, poverty, and unemployment, leading to violence. Although JASLWJ avows a religious purpose in its activities, it takes full advantage of the social and economic deprivation to recruit new members. For any viable short- or long-term solution, this article concludes that the country must go all-out with its anti-corruption crusade. This will enable the revival of other critical sectors such as agriculture and manufacturing, likely ensuring more employment. Should the country fail to stamp out corruption, it will continue to witness an upsurge in the activities of JASLWJ, and perhaps even the emergence of other violent groups. The spillover effects may be felt not only across Nigeria but also within the entire West African region.

Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling

Directory of Open Access Journals (Sweden)

Tzviya Zeev-Ben-Mordehai

2015-12-01

Full Text Available Although nucleo-cytoplasmic transport is typically mediated through nuclear pore complexes, herpesvirus capsids exit the nucleus via a unique vesicular pathway. Together, the conserved herpesvirus proteins pUL31 and pUL34 form the heterodimeric nuclear egress complex (NEC, which, in turn, mediates the formation of tight-fitting membrane vesicles around capsids at the inner nuclear membrane. Here, we present the crystal structure of the pseudorabies virus NEC. The structure revealed that a zinc finger motif in pUL31 and an extensive interaction network between the two proteins stabilize the complex. Comprehensive mutational analyses, characterized both in situ and in vitro, indicated that the interaction network is not redundant but rather complementary. Fitting of the NEC crystal structure into the recently determined cryoEM-derived hexagonal lattice, formed in situ by pUL31 and pUL34, provided details on the molecular basis of NEC coat formation and inner nuclear membrane remodeling.

The Prevalence and Nature of Unrequited Love

OpenAIRE

Robert G. Bringle; Terri Winnick; Robert J. Rydell

2013-01-01

Unrequited love (UL) is unreciprocated love that causes yearning for more complete love. Five types of UL are delineated and conceptualized on a continuum from lower to greater levels of interdependence: crush on someone unavailable, crush on someone nearby, pursuing a love object, longing for a past lover, and an unequal love relationship. Study 1a found all types of UL relationships to be less emotionally intense tha...

Protein kinases responsible for the phosphorylation of the nuclear egress core complex of human cytomegalovirus.

Science.gov (United States)

Sonntag, Eric; Milbradt, Jens; Svrlanska, Adriana; Strojan, Hanife; Häge, Sigrun; Kraut, Alexandra; Hesse, Anne-Marie; Amin, Bushra; Sonnewald, Uwe; Couté, Yohann; Marschall, Manfred

2017-10-01

Nuclear egress of herpesvirus capsids is mediated by a multi-component nuclear egress complex (NEC) assembled by a heterodimer of two essential viral core egress proteins. In the case of human cytomegalovirus (HCMV), this core NEC is defined by the interaction between the membrane-anchored pUL50 and its nuclear cofactor, pUL53. NEC protein phosphorylation is considered to be an important regulatory step, so this study focused on the respective role of viral and cellular protein kinases. Multiply phosphorylated pUL50 varieties were detected by Western blot and Phos-tag analyses as resulting from both viral and cellular kinase activities. In vitro kinase analyses demonstrated that pUL50 is a substrate of both PKCα and CDK1, while pUL53 can also be moderately phosphorylated by CDK1. The use of kinase inhibitors further illustrated the importance of distinct kinases for core NEC phosphorylation. Importantly, mass spectrometry-based proteomic analyses identified five major and nine minor sites of pUL50 phosphorylation. The functional relevance of core NEC phosphorylation was confirmed by various experimental settings, including kinase knock-down/knock-out and confocal imaging, in which it was found that (i) HCMV core NEC proteins are not phosphorylated solely by viral pUL97, but also by cellular kinases; (ii) both PKC and CDK1 phosphorylation are detectable for pUL50; (iii) no impact of PKC phosphorylation on NEC functionality has been identified so far; (iv) nonetheless, CDK1-specific phosphorylation appears to be required for functional core NEC interaction. In summary, our findings provide the first evidence that the HCMV core NEC is phosphorylated by cellular kinases, and that the complex pattern of NEC phosphorylation has functional relevance.

IMPLEMENTASI ISLAMIC CORPORATE GOVERNANCE DAN IMPLIKASINYA TERHADAP KINERJA BANK SYARIAH

Directory of Open Access Journals (Sweden)

Asrori -

2014-12-01

Full Text Available Penelitian ini bertujuan mengkaji implementasi Islamic corporate governance dan pengaruhnya terhadap kinerja bank syariah yang diukur menggunakan rasio-rasio keuangan Islami syari’ah conformity dan rasio-rasio keuangan konvensional  profitability. Populasi penelitian mencakup bank umum syariah (BUS dan unit usaha syariah (UUS. Pengumpulan data digunakan metode dokumentasi dengan unit analisis laporan keuangan dan self assesment good corporate governance BUS dan UUS yang terpilih sebagai sampel. Analisis data untuk menguji hipotesis digunakan regresi linier. Hasil penelitian menyatakan implementasi Islamic corporate governance pelaksanaan tugas dan tanggung jawab Dewan Pengawas Syariah (DPS berpengaruh positif terhadap kinerja bank syariah yang diukur menggunakan rasio-rasio keuangan syari’ah conformity  pembiayaan bagi hasil dan zakat, akan tetapi tidak berpengaruh positif  jika diukur menggunakan rasio pendapatan Islami. Implementasi Islamic corporate governance kepatuhan syariah berpengaruh positif terhadap kinerja bank syariah yang diukur menggunakan rasio-rasio keuangan syari’ah conformity  pembiayaan bagi hasil, pendapatan Islami dan zakat. Sedangkan implementasi Isamic corporate governance pelaksanaan tugas dan tanggung jawab DPS dan kepatuhan syariah tidak berpengaruh posisitf terhadap kinerja bank syariah yang diukur menggunakan rasio-rasio keuangan profitability  return on invesment,return on equity dan profit margin.This study aims to assess the implementation of Islamic corporate governance and its effect on the performance of Islamic banks as measured by Islamic financial ratios shari’ah conformity and konventional fiancial ratios profitability. The study population includes Islamic banks (Bank Umum Syariah/BUS and shari’a business units (Unit Usaha Syariah/UUS. The data collection methods used by documentation with unit analysis of financial statements and good corporate governance self-asessment BUS and UUS selected

Ku Klux Rising: Toward an Understanding of American Right Wing Terrorist Campaigns

Science.gov (United States)

2011-09-01

leadership of Adolf Hitler and his paramilitary Sturm Abteilung (SA); even Japanese succumbed to the ideas of the Society for the Preservation of the...Jihad (Hoboken, N.J.: John Wiley & Sons, 2008). 634 Tony Kaye, “American History X,” (United States: New Line Cinema , 1998). 241 and respected...Summer 1997). 262 Kaye, Tony. “American History X.” United States: New Line Cinema , 1998. Keefer, Philip, and Norman Loayza. Terrorism, Economic

Countering Threat Finance as a Critical Subset of Irregular Warfare: An Interpretive Case Study of Northern Nigeria

Science.gov (United States)

2009-05-01

It also includes monitoring the marketplace , craftsmanship, and manufacturing concerns to make sure that the laws of Islam are upheld by these... Yoruba Empire and infringement into the land of the Igbo in the middle and southern regions of modern day Nigeria respectively.88 The bulk of Nigeria’s...involving Muslim and non-Muslim groups; Hausa- Fulani 29 percent, Yoruba 21 percent, and Igbo 18 percent.89 The outcome of the Fulani Jihad was the

CTC Sentinel. Volume 6, Issue 1

Science.gov (United States)

2013-01-01

Verfassungsschutzbericht 2011,” Bundesamt für Ver- fassungsschutz, June 2012. The report distinguishes be- tween Salafists, al-Qa`ida and franchises , and regional jihadist...Unity and Jihad in West Africa. – AP, November 3 November 3, 2012 (SOMALIA): Two suicide bombers targeted the Vil lage restaurant and café near...Mogadishu’s Soobe intersection, ki l l ing at least one person. The restaurant is frequented by government off icials and members of the

Shift Focus on the Al Qaeda Network: A More Comprehensive Approach to Defeating Al Qaeda

Science.gov (United States)

2012-06-15

Declaration of jihad against the United States,” Al-Islah ( Internet ), September 2, 1996. As analyzed in Michael Scheuer, Osama bin Laden (New York...He enhanced his charismatic persona by deliberately modeling his life after that of Mohammed, the Islamic prophet.25 The irony of bin Laden is that...with the sensitive topic of a political ideology linked with a religion whose population is overwhelmingly distrustful of the U.S. Much has been made

The Grand Strategy of the Islamic State: What Can the Coalition Do About It

Science.gov (United States)

2016-02-10

the Yazidis into slavery (allowed by their strict and narrow interpretation of the Koran and the Hadith20), holds hostages for ransom, and assumes...borders of Iraq and Syria. In this regard, the more aggressive diplomacy should start with Saudi Arabia and Iran since they are waging proxy wars in...Affairs, Subcommittee on the Middle East and North Africa , United States House of Representatives, April 30, 2015 Kepel, Giles. Jihad: The Trail

United States Air Force Summer Faculty Research Program. 1985 Technical Report. Volume 1.

Science.gov (United States)

1985-12-01

this research effort was to evaluate the column technique for determining sorption coefficients of organic compounds onto soils. It was intended to... SORPTION COEFFICIENTS DETERMINED BY PULSE DISPLACEMENT Compound Flow Rate (mL/min) K,,q(mL/g) Trichioroethylene 0.2 0.054 0.2 0.057 Naphthalene 1.5...Vernon R. Allen Perfluorinated Polyalkylene Linked Polyimide 4 Quantifying Experience in the Cost Dr. Jihad A. Alsadek of Human Capital 5 The Effects

Religious Rhetoric in National Security Strategy Since 9/11

Science.gov (United States)

2012-03-22

what is embodied within and among human persons or political entities; it is for them quite literally a struggle among cosmic and supernatural ...of legitimate Muslim communities world-wide.97 Yet Ganor, in his Jerusalem Post article , If Global Jihad Isn’t the Enemy, What Is? argued that it...language. In her article , No Such Thing As Islamic Terrorism? Weiss argued that this softening is counterproductive to the promotion of NSS because it is

Sea-ice Thickness and Draft Statistics from Submarine ULS, Moored ULS, and a Coupled Model

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of estimates of mean values of sea-ice thickness and sea-ice draft in meters computed from three different input data sets: sea ice draft from...

Primary hepatic actinomycosis mimicking hepatic malignancy with metastatic lymph nodes by F-18 FDG PET/CT

International Nuclear Information System (INIS)

Kong, Eun Jung

2016-01-01

Hepatic involvement is usually secondary to abdominal actinomycosis infection. Symptom onset is typically subscute and the disease follows a chronic and indolent course. These lesions are called inflammatory pseudotumors and cannot be differentiated from malignant tumors by radiological examination alone. Laboratory tests showed mild anemia; hemoglobin 119 g/L, elevated white blood cell count of 23,060/mm 3 , AST 33 U/L, ALT 45 U/L, and γ-GT 155 U/L.

Primary hepatic actinomycosis mimicking hepatic malignancy with metastatic lymph nodes by F-18 FDG PET/CT

Energy Technology Data Exchange (ETDEWEB)

Kong, Eun Jung [Yeungnam Univ. Medical School and Hospital, Daegu (Korea, Republic of)

2016-03-15

Hepatic involvement is usually secondary to abdominal actinomycosis infection. Symptom onset is typically subscute and the disease follows a chronic and indolent course. These lesions are called inflammatory pseudotumors and cannot be differentiated from malignant tumors by radiological examination alone. Laboratory tests showed mild anemia; hemoglobin 119 g/L, elevated white blood cell count of 23,060/mm{sup 3}, AST 33 U/L, ALT 45 U/L, and γ-GT 155 U/L.

Taking Jihad Out of the Hands of Infidels

Science.gov (United States)

2007-06-01

both Mecca and Medina from the Turks. In taking Mecca, the Wahhabis demonstrated their religious ferocity by destroying the tomb of Muhammad...did not sit well with the Turkish sultan. He tasked Mehmed Ali, the Egyptian Sultan, “to recover the holy cities.”73 On their third attempt, the...notable contributor to this transformation was an Egyptian named Sayyed Qutb, whose book, Milestones, was published in 1964. Qutb developed and

Shaping Jihadism: How Syria Molded the Muslim Brotherhood

National Research Council Canada - National Science Library

Krummrich, Seth

2007-01-01

In February 1982, Syrian President Assad's military and security forces surrounded, assaulted, and leveled the fourth largest city in Syria, Hama, killing between 5,000-25,000 Syrians in less than three weeks...

Global Insurgency Strategy and the Salafi Jihad Movement

Science.gov (United States)

2008-04-01

Coll and Glasser,  is through public e­mail services such as  Hotmail . Here is how it  works: An operative opens an account on Hotmail , “writes a...secretly, reported by Coll and Glasser,  is through public e­mail services such as  Hotmail . Here is how it  works: An operative opens an account on... Hotmail , “writes a message  in draft form, saves it as a draft, and then transmits the e­mail account  name and password during chatter on a relatively

Shari’ah Compliant Finance: Toward Economic Jihad

Science.gov (United States)

2010-04-12

aig/ takaful /index.jsp (all three accessed October 9, 2009). 48 Hunt Janin and Andre Kahlmeyer, Islamic Law: The Sharia from Muhammad’s Time to the...Group. AIG- Takaful . October 9, 2009. http://www.aigtakaful- enaya.com/aig/ takaful /index.jsp (accessed October9, 2009). Anti-Defamation League

Global Salafist Jihad in UK -- Strategies of Prevention

Science.gov (United States)

2007-05-24

global Jihadist movement has become decentralised and more diffuse, events in Iraq are shaping a new generation of terrorist leaders and operatives...Qaeda’s(pl~ers could conceive, plan and prepare attacks. Germany was favoured due to their security forces’ ignorance ofMiddle Eastern networks - most...social value, there is little intellectkI energy devoted to a better understanding of radicalisation and methods to blunt its ¢ffect, a paucity of

Upper and lower limb functionality and body mass index in physically active older adults

Directory of Open Access Journals (Sweden)

Juliana Molinari Tecchio

Full Text Available Abstract Introduction: Aging leads to sarcopenia and functional capacity decline, compromising upper (UL and lower limb (LL performance of activities. Body mass index (BMI is an important parameter for the assessment of health conditions in older adults, especially with regard to obesity, since it leads to functional limitations in terms of mobility and task performance. Objective: To investigate the potential association between UL and LL functionality and BMI in physically active older adults; and to characterize this population with regard to BMI and UL and LL functionality. Methods: The data were collected between August 2013 and April 2014. The sample comprised 371 physically active older adults. This study used secondary data from the program “PET Saúde IPA/SMS”. The program interviewed older adults living in areas comprised by the Third Family Health Unit of a neighborhood in Porto Alegre/RS. This paper used questions from the “Instrumento de Avaliação Multidimensional Rápida da Pessoa Idosa” (Instrument for Rapid Multidimensional Assessment of Elderly People, in English that had to do with UL and LL functionality, weight, height and BMI. Results and Conclusion: There was no association between UL and LL functionality and BMI in physically active older adults. More than half of the sample was overweight. Most participants had functional UL and LL. While occupation, self-perception of health as “good” and “very good”, and physical activity were found to be associated with LL functionality; regular physical exercise was found to be associated with UL and LL functionality.

A subset of herpes simplex virus replication genes induces DNA amplification within the host cell genome

Energy Technology Data Exchange (ETDEWEB)

Heilbronn, R.; zur Hausen, H. (Deutsches Krebsforschungszentrum, Heidelberg (West Germany))

1989-09-01

Herpes simplex virus (HSV) induces DNA amplification of target genes within the host cell chromosome. To characterize the HSV genes that mediate the amplification effect, combinations of cloned DNA fragments covering the entire HSV genome were transiently transfected into simian virus 40 (SV40)-transformed hamster cells. This led to amplification of the integrated SV40 DNA sequences to a degree comparable to that observed after transfection of intact virion DNA. Transfection of combinations of subclones and of human cytomegalovirus immediate-early promoter-driven expression constructs for individual open reading frames led to the identification of sic HSV genes which together were necessary and sufficient for the induction of DNA amplification: UL30 (DNA polymerase), UL29 (major DNA-binding protein), UL5, UL8, UL42, and UL52. All of these genes encode proteins necessary for HSV DNA replication. However, an additional gene coding for an HSV origin-binding protein (UL9) was required for origin-dependent HSV DNA replication but was dispensable for SV40 DNA amplification. The results show that a subset of HSV replication genes is sufficient for the induction of DNA amplification. This opens the possibility that HSV expresses functions sufficient for DNA amplification but separate from those responsible for lytic viral growth. HSV infection may thereby induce DNA amplification within the host cell genome without killing the host by lytic viral growth. This may lead to persistence of a cell with a new genetic phenotype, which would have implications for the pathogenicity of the virus in vivo.

RBC acetyl cholinesterase: A poor man′s early diagnostic biomarker for familial alzheimer′s and Parkinson′s disease dementia

Directory of Open Access Journals (Sweden)

Himmatrao Saluba Bawaskar

2015-01-01

Full Text Available Objective: Analysis of red blood cell acetyl cholinesterase (AChE in a familial Alzheimer′s diseases (AD Parkinson′s disease dementia (PDD and their first generation. Setting: General hospital, Mahad district, Raigad. Patients and Methods: Clinically diagnosed patients of AD and PDD and their asymptomatic relatives. Their blood was collected in EDTA tube and transferred to laboratory at Mumbai. Result: Median red blood cell (RBC cholinesterase levels amongst PDD, their first generation asymptomatic relatives, familial AD, asymptomatic relatives of AD, healthy controls, farmers exposed to pesticides (positive control and other neurological condition without dementia (hypertension with TIA 1, sub-dural hematoma 2, hypothyroid 1, non-familial unilateral parkinsonism without dementia 3, writers cramps 2, hyponitremia 1 and cerebral palsy with non-fluent aphasia 1. Median values of RBC AChE were 19086.78 U/L, 15666.05 U/L, 9013.11 U/L, 7806.19 U/L, 14334.57 U/L, 9785.05 U/L and 13162.60 U/L, respectively. As compared to controls, RBC AChE levels were statistically significant among PDD (P = 0.004 and significantly lowered among familial AD patients (P = 0.010, relatives of patients (P = 0.010. Interpretations: Below the normal RBC AChE level is a potential biomarker in asymptomatic relatives of familial AD patients. RBC AChE is raised than normal level in patients suffering from PDD, where AChE inhibitors are helpful. However, RBC AChE level below the normal where AChE inhibitor may not be effective.

Pemberdayaan Pesantren: Membangun Generasi Islami melalui Pembinaan Keterampilan Berbahasa Asing

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Hari Prastyo

2017-08-01

Full Text Available Pesantren is a religious educational institution managed by the society that is called as Pengasuh. Therefore, Pengasuh is a leader in a community. The educational background of Pengasuh effects activities developed in it. Furthermore, the activities in pesantren relate to the students’ competence and skills. In the modern and global world, the students’ competence and skills should be the primary consideration in developing program at Pesantren. One of the competencies and skills that must be mastered by the students are foreign-language skills. This article discussed about Pesantren Empowerment through the Development of Foreign Language Skills Program to Create an Islamic Generation. This was a research article that used Research and Development Design. This research was conducted at Pesantren I'anatut Tholibin Mojokerto. The first step of this research was to do Need Analysis by using questionaire and interview. Based on the results of questionaire and interview, the researchers developed a program to empower pesantren. The results of this research will be useful for pengasuh, because the result of this research will give a real contribution for pesantren in the form of program that is related to the competence and skills of students as a form of empowerment for pesantren

BER-EUKA KERJA ISLAMI: IBADAH DAN DAKWAH DI TEMPAT KERJA

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Aris Nurohman

2016-11-01

Full Text Available Islamic work ethic is an Islamic ethic that has been pradiced among the staff base on Islamideaching. islamic work ethic is very important applied in the workplace as a guide staff in performing work in accordance with the values of religious teachings, because the Islamic religion is not only seen as the work of worshipthatwill getthe reward forthe perpetrators, butalso can affedtheformation of a good culture work environment. In this case the ethical work has implications for the effort dakwah bil hal to others in the work environment.

Al-Salaf wa al-Salafiyah fi al-Fikr al-Islamy

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Amal Fathullah Zarkasyi

2009-05-01

Full Text Available The principles of salafiah approach can be summarized into three distinguished characteristics: first is comprehension, second is authenticity or originality and not imitation (taqlid, while the last is improvement or progress and not conservatism. Salafiah is in fact not inconsistent with the progress and improvement, while their calling for returning to the original and main sources is approved by the religion and not in contradiction with the reality of Muslim. Moreover, it is a valid approach in achieving a better life in this world and hereafter. The objectives of salafiah are to purify the faith from the heresies (bid’ah, to educate Islamic personality, to open human mind to accept all the new in the fields of the experimental sciences, and to establish the faith from its sources which is far from the emerging narrow-minded religion sects recently. Finally, the salafist open widely to the experimental sciences, to the uses of scientific results, to the great invention in industrial sector and to the modern technology as they are very useful to support and sustain the Islamic teachings in the context of a more beautiful life with a less difficulties.

The measurement of TSH-receptor autoantibodies in human serum by radioreceptor assay

International Nuclear Information System (INIS)

Truong, T.X.

2002-01-01

TSH receptor autoantibodies (TRAB) are valuable in Graves' disease with a sensitivity of 85% and a specificity of 80%. Autoantibodies levels decrease progressively with antithyroid drugs treatment or after thyroidectomy. The predictive value of the level of TSH receptor autoantibodies is diversely appreciated. Nevertheless, the vast majority of the studies agrees on the fact that high levels of TSH receptor autoantibodies predict a relapse. The feto-placental transfer of these antibodies could explain congenital hyperthyroidism of newborns from mother affected by Graves' disease. These antibodies are present in certain cases of Hashimoto thyroiditis, subacute thyroiditis or silent thyroiditis in phase of thyrotoxicosis. In Vietnam, first time we have researched determination of TRAB levels in the non disease and the Graves' disease, after treatment of antithyroid drugs and after thyroidectomy. We imported TRAB - Kit from CIS bio international France. The principle of Radioreceptor assay (RRA ) is following: TR - Ab kit utilizes a principle of competition between TSH receptor autoantibodies present in the sample and bovine TSH radiolabelled with 125 -I, facing a fixed and limited amount of soluble porcine TSH receptors. The more TSH receptor autoantibodies are present in the sample, the less 125 -I- TSH is bound to the soluble TSH receptors. Free and bound fractions are separated in adding PEG solution followed by a centrifugation. Results are calculated from a calibration curve (U/l). The samples were counted by the multi crystal gamma counter Oakfield which was supplied from IAEA (Years 2000). This is the first study in Vietnam, the concentration of TSH receptor autoantibodies (TRAB) was determined by radioreceptor assay (RRA) on 30 normal subjects and 30 Grave's disease subjects. The normal range is 1,4 □ 0.6 U/l. Max of normal is 2.99U/l. Min of normal is 3.38U/l .There are 11 males and 29 females with age from 15 to 50 years old. Mean of Graves' disease is

Alternative Fuels Data Center: Status Update: Clarification of Ethanol

Science.gov (United States)

Laboratories (UL) certifications have generated a lot of questions and led to confusion. Discussions about guidelines are established that approve higher ethanol blend levels for public use, UL will review products

24 CFR 3280.703 - Minimum standards.

Science.gov (United States)

2010-04-01

.... Factory-Built Fireplaces, Seventh Edition—UL 127-1996, with 1999 revisions. Solid-Fuel Type Room Heaters, Fifth Edition—UL 1482, 1995, with 2000 revisions. Fireplace Stoves, Eight Edition, with 2000 revisions...

Gemfibrozil-induced myositis in a patient with normal renal function.

Science.gov (United States)

Hahn, Martin; Sriharan, Kalavally; McFarland, M Shawn

2010-01-01

To describe a case of gemfibrozil monotherapy-induced myositis in a patient with normal renal function A 68-year-old white man presented to his primary care clinic complaining of a 6-month history of total body pain. His past medical history was significant for hypertension, diabetes mellitus, hyperlipidemia, gastroesophageal reflux disease, benign prostatic hypertrophy, arthritis, impotence, and pancreatic cancer that required excision of part of his pancreas. His home drug regimen included bupropion 75 mg twice daily, gemfibrozil 600 mg twice daily for the past 8 months, glimiperide 1 mg daily, insulin glargine 5 units at bedtime, insulin aspart 5 units in the evening, lisinopril 10 mg daily, omeprazole 40 mg daily, pregabalin 100 mg daily, and sildenafil 100 mg as needed. Laboratory test results were significant for elevated aspartate aminotransferase (AST) 78 U/L (reference range 15-46 U/L), alanine aminotransferase (ALT) 83 U/L (13-69 U/L), and creatine kinase (CK) 3495 U/L (55-170 U/L). Serum creatinine was normal at 1.19 mg/dL. The physician determined that the elevated CK indicated myositis secondary to gemfibrozil use, and gemfibrozil was subsequently discontinued. The patient returned 1 week later to repeat the laboratory tests. Results were CK 220 U/L, AST 26 U/L, ALT 43 U/L, and serum creatinine 1.28 mg/dL. The patient was asked to return in 3 weeks to repeat the laboratory tests. At that time, CK had continued to decrease to 142 U/L, and the AST and ALT had returned to normal, at 22 and 29 U/L, respectively. The patient reported complete resolution of total body pain 3 weeks after discontinuation of gemfibrozil. Follow-up 5 weeks after discontinuation revealed no change compared to the 3-week follow-up. Myositis most often produces weakness and elevated CK levels more than 10 times the upper limit of normal. The risk of developing myositis, myopathy, or rhabdomyolysis is low (1%) when fibrates such as gemfibrozil are used as monotherapy. Evaluation of

Improvement of Folate Biosynthesis by Lactic Acid Bacteria Using Response Surface Methodology

Directory of Open Access Journals (Sweden)

Norfarina Muhamad Nor

2010-01-01

Full Text Available Lactic acid bacteria (Lactococcus lactis NZ9000, Lactococcus lactis MG1363, Lactobacillus plantarum I-UL4 and Lactobacillus johnsonii DSM 20553 have been screened for their ability to produce folate intracellularly and/or extracellularly. L. plantarum I-UL4 was shown to be superior producer of folate compared to other strains. Statistically based experimental designs were used to optimize the medium formulation for the growth of L. plantarum I-UL4 and folate biosynthesis. The optimal values of important factors were determined by response surface methodology (RSM. The effects of carbon sources, nitrogen sources and para-aminobenzoic acid (PABA concentrations on folate biosynthesis were determined prior to RSM study. The biosynthesis of folate by L. plantarum I-UL4 increased from 36.36 to 60.39 µg/L using the optimized medium formulation compared to the selective Man de Rogosa Sharpe (MRS medium. Conditions for the optimal growth of L. plantarum I-UL4 and folate biosynthesis as suggested by RSM were as follows: lactose 20 g/L, meat extract 16.57 g/L and PABA 10 µM.

Active evolution of memory B-cells specific to viral gH/gL/pUL128/130/131 pentameric complex in healthy subjects with silent human cytomegalovirus infection.

Science.gov (United States)

Xia, Lin; Tang, Aimin; Meng, Weixu; Freed, Daniel C; He, Linling; Wang, Dai; Li, Fengsheng; Li, Leike; Xiong, Wei; Gui, Xun; Schultz, Robbie D; Chen, Haotai; He, Xi; Swoyer, Ryan; Ha, Sha; Liu, Yaping; Morris, Charles D; Zhou, Yu; Wang, I-Ming; Zhao, Qinjian; Luo, Wenxin; Xia, Ningshao; Espeseth, Amy S; Hazuda, Daria J; Rupp, Richard E; Barrett, Alan D; Zhang, Ningyan; Zhu, Jiang; Fu, Tong-Ming; An, Zhiqiang

2017-09-26

Human cytomegalovirus (HCMV) can cause life-threatening infection in immunosuppressed patients, and in utero infection that may lead to birth defects. No vaccine is currently available. HCMV infection in healthy subjects is generally asymptomatic, and virus persists as latent infection for life. Host immunity is effective against reactivation and super-infection with another strain. Thus, vaccine candidates able to elicit immune responses similar to those of natural infection may confer protection. Since neutralization is essential for prophylactic vaccines, it is important to understand how antiviral antibodies are developed in natural infection. We hypothesized that the developmental path of antibodies in seropositive subjects could be unveiled by interrogating host B-cell repertoires using unique genetic signature sequences of mAbs. Towards this goal, we isolated 56 mAbs from three healthy donors with different neutralizing titers. Antibodies specific to the gH/gL/pUL128/130/131 pentameric complex were more potent in neutralization than those to gB. Using these mAbs as probes, patterns of extended lineage development for B-cells and evidence of active antibody maturation were revealed in two donors with higher neutralizing titers. Importantly, such patterns were limited to mAbs specific to the pentamer, but none to gB. Thus, memory B-cells with antiviral function such as neutralization were active during latent infection in the two donors, and this activity was responsible for their higher neutralizing titers. Our results indicated that memory B-cells of neutralizing capacity could be frequently mobilized in host, probably responding to silent viral episodes, further suggesting that neutralizing antibodies could play a role in control of recurrent infection.

CTC Sentinel. Volume 7, Issue 6, June 2014

Science.gov (United States)

2014-06-01

The f ighters were very animated and emotional when answering this question. J ihad, for them, is an ult imate, purifying expression of faith...aspects of life… it gives meaning to the human life. I have devoted my entire life for jihad. All my bodily parts are wounded. I am only looking up to...of Colombia – People’s Army,” Mapping Militant Organizations, Stanford Uni- versity, August 13, 2012. unclear whether the central command of the

The Caliphates Global Workforce: An Inside Look at the Islamic States Foreign Fighter Paper Trail

Science.gov (United States)

2016-04-01

this older group had fought in Mali. Just outside this group is an Egyptian born in 1960 who stated that he had participated in the anti-Soviet jihad in...A supervisor of a computer division at an Egyptian chemical company, and; • One ambitious individual who listed all the following areas of... architecture for an accessible and editable per- sonnel database, but based on the information in this cache, it does not appear that their vision was ever

Re-integration of Former Liberation Tigers of Tamil Eelam Combatants into Civilian Society in Post-War Sri Lanka

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2012-03-01

to national and local requirements.35 In Burundi, the peace efforts were also characterized by an approach "in stages,” said Isaiah Nibizi, head...Guantanamo Returnees, Combating Terrorism Center at West Point,” CTC Sentinel 1, Issue 1, 10–11. 80 Thomas W. Lippman W (2012), Saudi Arabia on the Edge...CRS Report for Congress, 29–30. 84 Thomas Hegghammer (2010), Jihad in Saudi Arabia: Violence and Pan-Islamism Since 1979, London: Cambridge

Wars of Ideas and the War of Ideas

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2008-06-01

recruits and [to] defeat homegrown extremism.”9 Dissatisfaction with certain U.S. policies does not necessarily equate to support for a global jihad...emotional force. This was also true of McCarthy’s more secular brand of inquisition. That Hitler, Stalin, and Mao used force in their ideological struggles...successful advertising campaigns in the United States include: Nike , “Just Do It” (1988); Miller Lite, “Tastes great, less filling” (1974); Avis, “We try

A Balancing Act: Anti-Terror Financing Guidelines and Their Effects on Islamic Charities

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2006-12-01

wayfarers; those in bondage or in debt ; newcomers to Islam; and, to facilitate and enhance Jihad. Zakat has become an important component of the... reason for this is that terrorist financing is not only an indicator but also the source and means of enabling those who carry out violent acts. As... reasons or for “preserving family wealth.”31 The long history of the waqf, fourteen centuries after the death of the Prophet, and the permanent

Basic Science of the Fundamentals and Dynamics of Social-Fringe Group Formation and Sustainment

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2012-08-01

USTIFY! G BELIEFS: WHAT MOTIVATES THE TERRORISTS •:• A 1-’ltmdry l.ist of 1\\lotivations: llonor, Trauma, Religion, llumtli:uion, Sugma, Feminism ...Group Grievance and Humiliation: A Tool in AI-Qaeda Propaganda •Jihad in Algeria today is YOUR hope with permission from Allah in redemption from...relational) and Morality ! 54! "Hear, Israel, the decrees and laws I declare in your hearing today . Learn them and be sure to foLlow them. The

Al Sahawa - The Awakening: An Education and Training Resource Guide

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2015-07-01

by US personnel at Abu Ghraib prison. These and related is- sues, festering since 2003, gained traction in the spring of 2004 and provided recruitment...Iraqi people to fight the occupiers, the ex- tremists, led by the Jordanian Abu Musab al-Zarqawi, demanded to lead the jihad with the intent of first...the Apr 2004 fight for Fallujah,” Abu Nour, insurgent and kidnapper of Jill Carroll; “The Jill Carroll Story, ”Christian Science Monitor (18 Aug

Intellectual Reviews of Fundamentalist Islamic Groups’ Leaders and their Impact on the Jihadi Action, the Muslim World, and the West

Science.gov (United States)

2010-06-11

wrestling and karate , and pushed the members of the university students from the group for conversion to military colleges to use them for a military coup...district of Cairo. The Prime Minister was unhurt, but some passersby suffered various injuries . The Islamic Jihad Group assassinated the first witness...side invites Allah’s curse on the party that is lying.” Dr. Fadl adds insult to injury when he stated that “some people pay money for fame, or to

Nietzsche l'islam et la globalisation | Monia | African Sociological ...

African Journals Online (AJOL)

le printemps arabe », ou les révolutions du siècle, se sont déclenchées avec une aspiration d'un monde sous développé a la liberté, la modernité et la démocratie. Les faits nous mènent vers un total détournement des buts de ce « printemps arabe ». Obscurantisme, islamisme, jihad, théocratie s'installent. Le siècle exprime ...

Hyporheic fauna from interstitial of the Someş River basin (Transylvania, northwestern Romania

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Claudia Pavelescu

2009-01-01

Full Text Available Biodiversity in hyporheic habitats (interstitial water habitats in river bank sediments has been studied on Someşul Cald (Warm Someş and Someşul Rece (Cold Someş River (north-western Romania, Transylvania, from March to October 2004. pH and electrical conductivity were measured monthly at each site, and animals were collected with the Karaman-Chappuis method and by filtering water through a hand-net. The relative abundance of the best-represented hyporheic invertebrates (oligochaetes and insect larvae was higher in Someşul Cald interstitial habitats than in Someşul Rece. The focus was directed to the role of water mites (Acari, Hydrachnidia, cyclopoid copepods (Crustacea, Copepoda, Cyclopoida and oligochaetes (Annelida, Oligochaeta in hyporheic communities. Nine water mites and five cyclopoid species were identified in five sampling sites of the two rivers. Their higher diversity was recorded in two stations on the Someşul Cald River. The cyclopoid copepod Diacyclops disjunctus (Thallwitz, 1927 is a new record for Romania. As for oligochaetes, 17 species were identified and their higher diversity was recorded on Someşul Rece River. Canonical Correspondence Analysis (CCA shows that presence of some water mites and cyclopoid species can be associated with measured physicochemical parameters (pH, electrical conductivity. Principal Component Analysis (PCA shows similarities between stations and the dominant taxa in some samples.

Plus- and minus-end directed microtubule motors bind simultaneously to herpes simplex virus capsids using different inner tegument structures.

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Kerstin Radtke

2010-07-01

Full Text Available Many viruses depend on host microtubule motors to reach their destined intracellular location. Viral particles of neurotropic alphaherpesviruses such as herpes simplex virus 1 (HSV1 show bidirectional transport towards the cell center as well as the periphery, indicating that they utilize microtubule motors of opposing directionality. To understand the mechanisms of specific motor recruitment, it is necessary to characterize the molecular composition of such motile viral structures. We have generated HSV1 capsids with different surface features without impairing their overall architecture, and show that in a mammalian cell-free system the microtubule motors dynein and kinesin-1 and the dynein cofactor dynactin could interact directly with capsids independent of other host factors. The capsid composition and surface was analyzed with respect to 23 structural proteins that are potentially exposed to the cytosol during virus assembly or cell entry. Many of these proteins belong to the tegument, the hallmark of all herpesviruses located between the capsid and the viral envelope. Using immunoblots, quantitative mass spectrometry and quantitative immunoelectron microscopy, we show that capsids exposing inner tegument proteins such as pUS3, pUL36, pUL37, ICP0, pUL14, pUL16, and pUL21 recruited dynein, dynactin, kinesin-1 and kinesin-2. In contrast, neither untegumented capsids exposing VP5, VP26, pUL17 and pUL25 nor capsids covered by outer tegument proteins such as vhs, pUL11, ICP4, ICP34.5, VP11/12, VP13/14, VP16, VP22 or pUS11 bound microtubule motors. Our data suggest that HSV1 uses different structural features of the inner tegument to recruit dynein or kinesin-1. Individual capsids simultaneously accommodated motors of opposing directionality as well as several copies of the same motor. Thus, these associated motors either engage in a tug-of-war or their activities are coordinately regulated to achieve net transport either to the nucleus during

Abnormal uterine bleeding as a presenting symptom is related to multiple uterine leiomyoma: an ultrasound-based study

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Fonseca-Moutinho JA

2013-10-01

Full Text Available José Alberto Fonseca-Moutinho,1,2 Lígia Silva Barbosa,1 Daniel Gonçalves Torres,1 Sara Morgado Nunes31Faculty of Health Sciences, School of Medicine, Beira Interior University, Covilhã, Portugal; 2Child and Women Department, Cova da Beira Academic Medical Center, Covilhã, Portugal; 3Polytechnic Institute of Castelo Branco, Castelo Branco, PortugalPurpose: To determine the prevalence of uterine leiomyomas, diagnosed by ultrasound, in a private health care setting located in the central eastern region of Portugal, and to explore the demographic and clinical factors related to diagnosis and symptomatology.Patients and methods: The files of 624 patients attending a private clinic in Covilhã, Portugal, from January 2 to December 31, 2010 were retrieved for evaluation. Pelvic ultrasound record, age, weight, height, age at menarche, number of pregnancies and deliveries, marital status, menstrual cycles characteristic, and contraceptive method at consultation were included in the analysis.Results: Uterine leiomyoma (UL was diagnosed by ultrasonography in 161 (25.8% patients. A single UL was diagnosed in 80 (49.7% patients. In 79 (49.1% patients, the largest leiomyoma had a dimension <20 mm. Prevalence of UL was age dependent: at 11.0% for women 20–39 years old; 45.4% for those aged 40–59 years; and 19.5% for women 60 years or older. Metrorrhagia was the most distressing presenting symptom. When menorrhagia was the presenting symptom, the probability of having an ultrasound diagnosis of UL was 73.3%. Metrorrhagia or menorrhagia, as presenting symptom, was significantly related to the ultrasound diagnosis of multiple ULs.Conclusion: UL was especially prevalent in women aged between 40 and 59 years. Patients with multiple ULs had significantly more abnormal uterine bleeding. In patients with menorrhagia or metrorrhagia, special attention should be taken in searching for the presence of multiple ULs during ultrasound.Keywords: fibroid, leiomyoma

FINDING ISLAM IN CINEMA: Islamic Films and the Identity of Indonesian Muslim Youths

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H Hariyadi

2013-12-01

Full Text Available This paper discusses Islamic films in Indonesia that have been a phenomenon since a decade. It is reported that Islamic films have been consciously produced to propagate Islamic lessons to the Muslim youths. The paper challenges the notion that young adults are passive recipients as proposed by some popular culture theorists. They did not merely become object of ideologies injected by filmmakers, and their responses were not an unquestioning acceptance. The research found that some Muslim youths have been ambiguous toward the emergence of Islamic films. Watching movie for Indonesian youths is an important way to construct identity, and they feel that there is a sense of religious ritual involved in film viewing, especially with Islamic messages. I argue that Islamic films help Indonesian young people to develop their own distinctive identity, being new sources of authority apart from parents, formal education, and friends.[Tulisan ini membahas film islami di Indonesia yang menjadi fenomena sejak satu dekade terakhir. Film-film islami sengaja dibuat untuk menyebarkan ajaran Islam dengan sasaran kalangan muda. Makalah ini menolak gagasan bahwa remaja adalah penerima pasif seperti yang diajukan oleh teori budaya popular. Mereka tidak hanya menjadi objek desakan ideologi pembuat film dan mereka juga tidak bisa menerimanya secara bulat. Sebagian pemuda muslim merasa ambigu menghadapi munculnya film-film Islam. Di sisi lain, menonton film menjadi media untuk membangun identitas diri dan dapat dirasakan sebagai bagian dari ritual agama, khususnya ketika menonton film yang mengandung pesan-pesan Islam. Dengan demikian, film Islam membantu pemuda Indonesia untuk mengembangkan identitas mereka sendiri dan menjadi sumber otoritas baru di luar orang tua, pendidikan formal, dan lingkungan pergaulan.]Keywords: religious film, youth identity, Islamic cinema

Reaktualisasi Strategi Pendidikan Islam: Ikhtiar Mengimbangi Pendidikan Global

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M. Sobry

2014-06-01

Full Text Available Abstract: Globalization is inevitable phenomenon that may cause anxiety amongst countries, such as Indonesia, that still preserve their culture, ethics and religious values because it always introduces new things that are not easily adjusted to regional or local contexts. Globalization as it is reflected in rapid change and transformation in technology has affected most of human’s life, including education. Globalized education is the one that is characterized by global and transnational elements in its basic structure, for example, the use of information technologies and digital media that have both positive and negative impacts. However, for Indonesia, whose majority population is Islam, globalization is not a threat, which should be evaded. What needs to do is to integrate Islamic concepts and values in it. Globalization and its type of education that looks contrary to religious norms will no longer become a menace if it is strengthened with religious values.    Abstrak: Globalisasi merupakan fenomena kekinian yang terkadang dipandang sebagai momok dalam konteks bangsa, seperti Indonesia, yang berhasrat kuat melestarikan nilai adat, budaya, moral, dan nilai agama. Tulisan ini mencermati globalisasi yang memengaruhi dunia pendidikan sebagaimana terlihat pada semakin luasnya penggunaan media digital dengan semua manfaat dan mudarat yang menyertainya. Penulis berpendapat bahwa fenomena itu semestinya dipandang wajar dan dihadapi dengan lapang dada. Namun ia harus diimbangi dengan konsep-konsep islami dan diperkuat dengan strategi islami pula. Islam memiliki konsep moralitas dan etika yang komprehensif untuk diaktualisasikan dalam konteks arus globalisasi. Oleh karena itu, tidak ada jalan lain untuk mengimbangi pendidikan global saat ini kecuali dengan kembali kepangkuan konsep-konsep pendidikan Islam. 

Ursodeoxycholic acid in neonatal sepsis-associated cholestasis

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Rita Mey Rina

2014-08-01

21.0 U/L vs -2.0 (ranged -167 .0 - 85.0 U/L; P= 0.730, median aspartate aminotransferase (AST levels [ 43 .0 (range 14.0-297 .0 U/L vs 150.0 (range 24.0-840.0 U/L; P=0.081, and median gamma-glutamyl transpeptidase (GGf levels [125.0 (48.0-481.0 U/L vs 235.0 (56.0-456.0 U/L; P=0.108. Five neonates in control group died compared to two in the UDCA group (P=0.232. In addition, UDCA did not significantly lengthen the survival time (hazard ratio/HR 3.62; 95%CI 0.69 to 18.77 . Conclusion Ursodeoxycholic acid tends to improve total bilirubin, direct bilirubin, and AST levels in sepsis associated cholestasis .

46 CFR 120.410 - Lighting fixtures.

Science.gov (United States)

2010-10-01

...) Each table lamp, desk lamp, floor lamp, or similar equipment must be secured in place so that it cannot... Fixtures,” UL 1571, “Incandescent Lighting Fixtures,” UL 1572, “High Intensity Discharge Lighting Fixtures...

46 CFR 125.180 - Incorporation by reference.

Science.gov (United States)

2010-10-01

... publish notice of change in the Federal Register and the material must be available to the public. All... Discharge Lighting Fixtures 129.410 UL 1573-1995, Stage and Studio Lighting Units 129.410 UL 1574-1995...

Effect of adenosine cyclophosphate combined with vitamin C on cellular immune function of children with viral myocarditis

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Xiu Chang

2016-06-01

Full Text Available Objective: To investigate the curative effect of adenosine cyclophosphate combined with vitamin C on children with viral myocarditis andon cellular immune function. Methods: A total of 96 cases of children with viral myocarditis were randomly divided into control group and observation group, 48 cases in each. The control group received routine treatment for viral myocarditis. The observation group received routine treatment for viral myocarditis as well as vitamin C and adenosine cyclophosphate. Results: The total effective rate of observation group 89.59% was higher than that of control group 64.58%, and differences were statistical significant. The electrocardiogram total effective rate of observation group 91.67% was higher than that of control group 68.75%, and differences were statistical significant. After treatment, the level of CD3+ (65.09±10.35%, the level of CD4+ (42.93±6.22%, the level of CD8+ (29.55±4.87% and the level of NK (47.37±8.52% of observation group were higher than the level of CD3+ (51.85±9.33%, the level of CD4+ (35.18±5.73%, the level of CD8+ (24.46±4.03% and the level of NK (35.64±7.72% of control group, and differences were statistical significant. After treatment, myocardial enzyme indexes lactate dehydrogenase (329.65±19.76 U/L, creatine phosphate kinase (126.36±12.92 U/L, hydroxybutyrate dehydrogenase (271.68±14.73 U/L, glutamic oxaloacetic transaminase (31.22±3.76 U/ L and creatine kinase (185.28±13.83 U/L of observation group were lower than lactate dehydrogenase (348.06±20.51 U/L, creatine phosphate kinase (163.19±13.15 U/L, hydroxybutyrate dehydrogenase (305.50±16.42 U/L, glutamic oxaloacetic transaminase (37.87±4.07 U/L and creatine kinase (202.79±15.47 U/L of control group, and differences were statistical significant. After treatment, heart function indexes CI, FS and EF levels of observation group were higher than those of control group, and differences were statistical significant

Dose-reduced CT with model-based iterative reconstruction in evaluations of hepatic steatosis: How low can we go?

Energy Technology Data Exchange (ETDEWEB)

Yasaka, Koichiro, E-mail: koyasaka@gmail.com [Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan); Katsura, Masaki [Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan); Akahane, Masaaki [NTT Medical Center Tokyo, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo 141-8625 (Japan); Sato, Jiro [Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan); Matsuda, Izuru [Kanto Rosai Hospital, 1-1 Kizukisumiyoshi-cho, Nakahara-ku, Kawasaki, Kanagawa 211-8510 (Japan); Ohtomo, Kuni [Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 (Japan)

2014-07-15

Purpose: To determine whether dose-reduced CT with model-based iterative image reconstruction (MBIR) is a useful tool with which to diagnose hepatic steatosis. Materials and methods: This prospective clinical study approved by our Institutional Review Board included 103 (67 men and 36 women; mean age, 64.3 years) patients who provided written informed consent to undergo unenhanced CT. Images of reference-dose CT (RDCT) with filtered back projection (R-FBP) and low- and ultralow-dose CT (dose-length product; 24 and 9% of that of RDCT) with MBIR (L-MBIR and UL-MBIR) were reconstructed. Mean CT numbers of liver (CT[L]) and spleen (CT[S]), and quotient (CT[L/S]) of CT[L] and CT[S] were calculated from selected regions of interest. Bias and limits of agreement (LOA) of CT[L] and CT[L/S] in L-MBIR and UL-MBIR (vs. R-FBP) were assessed using Bland–Altman analyses. Diagnostic methods for hepatic steatosis of CT[L] < 48 Hounsfield units (HU) and CT[L/S] < 1.1 were applied to L-MBIR and UL-MBIR using R-FBP as the reference standard. Results: Bias was larger for CT[L] in UL-MBIR than in L-MBIR (−3.18 HU vs. −1.73 HU). The LOA of CT[L/S] was larger for UL-MBIR than for L-MBIR (±0.425 vs. ±0.245) and outliers were identified in CT[L/S] of UL-MBIR. Accuracy (0.92–0.95) and the area under the receiver operating characteristics curve (0.976–0.992) were high for each method, but some were slightly lower in UL-MBIR than L-MBIR. Conclusion: Dose-reduced CT reconstructed with MBIR is applicable to diagnose hepatic steatosis, however, a low dose of radiation might be preferable.

Effects of resistance training using known vs unknown loads on eccentric-phase adaptations and concentric velocity.

Science.gov (United States)

Hernández-Davó, J L; Sabido, R; Behm, D G; Blazevich, A J

2018-02-01

The aims of this study were to compare both eccentric- and concentric-phase adaptations in highly trained handball players to 4 weeks of twice-weekly rebound bench press throw training with varying loads (30%, 50% and 70% of one-repetition maximum [1-RM]) using either known (KL) or unknown (UL) loads and to examine the relationship between changes in eccentric- and concentric-phase performance. Twenty-eight junior team handball players were divided into two experimental groups (KL or UL) and a control group. KL subjects were told the load prior each repetition, while UL were blinded. For each repetition, the load was dropped and then a rebound bench press at maximum velocity was immediately performed. Both concentric and eccentric velocity as well as eccentric kinetic energy and musculo-articular stiffness prior to the eccentric-concentric transition were measured. Results showed similar increases in both eccentric velocity and kinetic energy under the 30% 1-RM but greater improvements under 50% and 70% 1-RM loads for UL than KL. UL increased stiffness under all loads (with greater magnitude of changes). KL improved concentric velocity only under the 30% 1-RM load while UL also improved under 50% and 70% 1-RM loads. Improvements in concentric movement velocity were moderately explained by changes in eccentric velocity (R 2 =.23-.62). Thus, UL led to greater improvements in concentric velocity, and the improvement is potentially explained by increases in the speed (as well as stiffness and kinetic energy) of the eccentric phase. Unknown load training appears to have significant practical use for the improvement of multijoint stretch-shortening cycle movements. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

CLINICAL VALUE OF CHROMOGRANIN A IN GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS

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N. V. Lyubimova

2015-01-01

Full Text Available Background: Neuroendocrine tumors (NET is a heterogeneous group of neoplasms characterized by hypersecretion of biologically active sub- stances that manifests by specific syndromes and determines the clinical course of the disease. The most common NET types are those of gastrointestinal tract. The obligatory biochemical marker used in the examination of NET patients is chromogranin A (CgA.Aim: Evaluation of the CgA value for diagnostics and monitoring of gastrointestinal NETs.Materials and methods: A comparative study of plasma CgA levels was performed in 146 patients with gastroenteropancreatic neuroendocrine tu- mors and 66 healthy individuals using the enzyme immunoassay “Chromogranin A ELISA kit” (Dako A/S, Denmark.Results: CgA levels were significantly higher in patients with NETs of all localizations, such as pancreas, stomach, gut, small and large bowel, than in the healthy subjects (р < 0.000001. In NET patients, CgA secretion was highly variable, with the highest value in the group of patients with gastric NETs (102000 U/l. The highest CgA medians were detected in patients with small intestinal (183.9 U/l, colon (148.4 U/l and pancreatic (135.9 U/l NETs. There was an association between CgA secretion and extension or activity of NETs, with the highest median values in patients with hepatic metastases (395 U/l and those with carcinoid syndrome (352 U/l. The clinical significance of CgA as a NET marker was assessed using the cut-off value of 33 U/l, calculated according to the results in the control group. Overall diagnostic sensitivity of CgA in NET patients was high (85.8% with a specificity of 98.5%. Conclusion: The results obtained confirm a high sensitivity of CgA as a NET marker whose determination helps to improve accuracy of diagnostics and to assess NET prevalence.

Changes in Adenosine Deaminase Activity in Patients with Type 2 Diabetes Mellitus and Effect of DPP-4 Inhibitor Treatment on ADA Activity

Science.gov (United States)

Lee, Jae-Geun; Kang, Dong Gu; Yu, Jung Re; Kim, Youngree; Kim, Jinsoek; Koh, Gwanpyo

2011-01-01

Background Dipeptidyl peptidase 4 (DPP-4, also known as CD26) binds with adenosine deaminase (ADA) to activate T lymphocytes. Here, we investigated whether ADA activity is specifically affected by treatment with DPP-4 inhibitor (DPP4I) compared with other anti-diabetic agents. Methods Fasting ADA activity, in addition to various metabolic and biochemical parameters, were measured in 262 type 2 diabetes mellitus (T2DM) patients taking various anti-diabetic agents and in 46 non-diabetic control subjects. Results ADA activity was increased in T2DM patients compared with that in non-diabetic control subjects (mean±standard error, 23.1±0.6 U/L vs. 18.6±0.8 U/L; PADA activity was correlated with fasting plasma glucose (r=0.258, P9%) showed significantly increased ADA activity (21.1±0.8 U/L vs. 25.4±1.6 U/L; PADA activity in T2DM patients did not differ from those of other oral anti-diabetic agents or insulin. T2DM patients on metformin monotherapy showed a lower ADA activity (20.9±1.0 U/L vs. 28.1±2.8 U/L; PADA activity is increased in T2DM patients compared to that in non-diabetic patients, is positively correlated with blood glucose level, and that DPP4I has no additional specific effect on ADA activity, except for a glycemic control- or HbA1c-dependent effect. PMID:21738897

Solid-phase immunoradiometric assay for serum amyloid A protein using magnetisable cellulose particles

International Nuclear Information System (INIS)

De Beer, F.C.; Dyck, R.F.; Pepys, M.B.

1982-01-01

An immunoradiometric assay for human serum amyloid A protein (SAA) was developed using magnetisable cellulose particles as the solid phase. Rabbit antiserum to SAA was raised by immunization with SAA isolated from acute-phase serum by gel filtration in formic acid. The antiserum was rendered monospecific for SAA by solid-phase immunoabsorption with normal human serum, which contains only traces of SAA, and some was coupled covalently to the cellulose particles. Immunopurified anti-SAA antibodies were isolated from the monospecific anti-SAA serum by binding to, and elution from insolubilized acute-phase serum and were radiolabelled with 125 I. The assay was calibrated with an acute phase serum which contained 6000 times more SAA than normal sera with the lowest detectable level of SAA, and an arbitrary value of 6000 U/l was assigned to this standard. Sera were tested in the native, undenatured state and there was no increase in SAA immunoreactivity following alkali treatment or heating. The assay range was from 1-2000 U/l so that all SAA levels above 6 U/l could be measured on a single (1:6) dilution of serum. The intra- and interassay coefficients of variation were 11.7 and 15.0% respectively. Among 100 healthy normal subjects (50 male, 50 female) the median SAA level was 9 U/l, range <1-100, with 93% below 20 U/l and only 2% below the lower limit of sensitivity of the assay (1 U/l). (Auth.)

Influence of plants on the chemical extractability and biodegradability of 2,4-dichlorophenol in soil

International Nuclear Information System (INIS)

Boucard, Tatiana K.; Bardgett, Richard D.; Jones, Kevin C.; Semple, Kirk

2005-01-01

This study investigated the fate and behaviour of [UL- 14 C] 2,4-dichlorophenol (DCP) in planted (Lolium perenne L.) and unplanted soils over 57 days. Extractability of [UL- 14 C] 2,4-DCP associated activity was measured using calcium chloride (CaCl 2 ), acetonitrile-water and dichloromethane (DCM) extractions. Biodegradability of [UL- 14 C] 2,4-DCP associated activity was assessed through measurement of 14 CO 2 production by a degrader inoculum (Burkholderia sp.). Although extractability and mineralisation of [UL- 14 C] 2,4-DCP associated activity decreased significantly in both planted and unplanted soils, plants appeared to enhance the sequestration process. After 57 days, in unplanted soil, 27% of the remaining [UL- 14 C] 2,4-DCP associated activity was mineralised by Burkholderia sp., and 13%, 48%, and 38% of 14 C-activity were extracted by CaCl 2 , acetonitrile-water and DCM, respectively. However, after 57 days, in planted soils, only 10% of the [UL- 14 C] 2,4-DCP associated activity was available for mineralisation, whilst extractability was reduced to 2% by CaCl 2 , 17% by acetonitrile-water and 11% by DCM. This may be due to the effect of plants on soil moisture conditions, which leads to modification of the soil structure and trapping of the compound. However, the influence of plants on soil biological and chemical properties may also play a role in the ageing process

Changes in Adenosine Deaminase Activity in Patients with Type 2 Diabetes Mellitus and Effect of DPP-4 Inhibitor Treatment on ADA Activity.

Science.gov (United States)

Lee, Jae-Geun; Kang, Dong Gu; Yu, Jung Re; Kim, Youngree; Kim, Jinsoek; Koh, Gwanpyo; Lee, Daeho

2011-04-01

Dipeptidyl peptidase 4 (DPP-4, also known as CD26) binds with adenosine deaminase (ADA) to activate T lymphocytes. Here, we investigated whether ADA activity is specifically affected by treatment with DPP-4 inhibitor (DPP4I) compared with other anti-diabetic agents. Fasting ADA activity, in addition to various metabolic and biochemical parameters, were measured in 262 type 2 diabetes mellitus (T2DM) patients taking various anti-diabetic agents and in 46 non-diabetic control subjects. ADA activity was increased in T2DM patients compared with that in non-diabetic control subjects (mean±standard error, 23.1±0.6 U/L vs. 18.6±0.8 U/L; PADA activity was correlated with fasting plasma glucose (r=0.258, P9%) showed significantly increased ADA activity (21.1±0.8 U/L vs. 25.4±1.6 U/L; PADA activity in T2DM patients did not differ from those of other oral anti-diabetic agents or insulin. T2DM patients on metformin monotherapy showed a lower ADA activity (20.9±1.0 U/L vs. 28.1±2.8 U/L; PADA activity is increased in T2DM patients compared to that in non-diabetic patients, is positively correlated with blood glucose level, and that DPP4I has no additional specific effect on ADA activity, except for a glycemic control- or HbA1c-dependent effect.

Use of seaweed Ulva lactuca for water bioremediation and as feed additive for white shrimp Litopenaeus vannamei.

Science.gov (United States)

Elizondo-González, Regina; Quiroz-Guzmán, Eduardo; Escobedo-Fregoso, Cristina; Magallón-Servín, Paola; Peña-Rodríguez, Alberto

2018-01-01

Two experimental feeding trials were conducted during four weeks to evaluate the use of Ulva lactuca in shrimp culture: (1) for wastewater bioremediation, and (2) using different inclusion levels of U. lactuca meal in shrimp feed. In feeding trial 1, shrimp reared under seaweed U. lactuca water exchange in a re-circulation system (SWE) resulted in similar growth and feed utilization as shrimp reared with clean water exchange (CWE). Shrimp under no water exchange (NWE) resulted in significant lower growth and higher feed conversion rate (FCR) compared to the other treatments ( p   0.05). In feeding trial 2, U. lactuca biomass produced by wastewater bioremediation in SWE treatment were dried and ground to formulate diets containing 0, 1, 2, and 3% U. lactuca meal (0UL, 1UL, 2UL, and 3UL). Shrimp fed the 3 UL diet resulted in a significant ( p  shrimp lipid and carotenoid content by 30 and 60%, respectively, compared to control diet. Seaweed U. lactuca is suggested as a desirable species for wastewater bioremediation in integrated aquaculture systems, and its meal as a good feed additive for farmed shrimp.

Model-based iterative reconstruction for reduction of radiation dose in abdominopelvic CT: comparison to adaptive statistical iterative reconstruction.

Science.gov (United States)

Yasaka, Koichiro; Katsura, Masaki; Akahane, Masaaki; Sato, Jiro; Matsuda, Izuru; Ohtomo, Kuni

2013-12-01

To evaluate dose reduction and image quality of abdominopelvic computed tomography (CT) reconstructed with model-based iterative reconstruction (MBIR) compared to adaptive statistical iterative reconstruction (ASIR). In this prospective study, 85 patients underwent referential-, low-, and ultralow-dose unenhanced abdominopelvic CT. Images were reconstructed with ASIR for low-dose (L-ASIR) and ultralow-dose CT (UL-ASIR), and with MBIR for ultralow-dose CT (UL-MBIR). Image noise was measured in the abdominal aorta and iliopsoas muscle. Subjective image analyses and a lesion detection study (adrenal nodules) were conducted by two blinded radiologists. A reference standard was established by a consensus panel of two different radiologists using referential-dose CT reconstructed with filtered back projection. Compared to low-dose CT, there was a 63% decrease in dose-length product with ultralow-dose CT. UL-MBIR had significantly lower image noise than L-ASIR and UL-ASIR (all pASIR and UL-ASIR (all pASIR in diagnostic acceptability (p>0.65), or diagnostic performance for adrenal nodules (p>0.87). MBIR significantly improves image noise and streak artifacts compared to ASIR, and can achieve radiation dose reduction without severely compromising image quality.

CTC Sentinel. Volume 3, Issue 7, July 2010

Science.gov (United States)

2010-07-01

as peculiar, but it is a visible manifestation of the depth of divide between the Sunni and Shi`a jihads.” 3 Since 2003, al-Qa`ida’s franchise in...Kampala, on July 11, 2010.1 The attacks— targeting a rugby club and an Ethiopian restaurant in a neighborhood popular with expatriates as people watched... franchises ” such as the Ghazi Force only if they prove worthy of attention. Thus, newly emerging groups have to prove themselves to the TTP high

Melacak Gerakan Radikal Islam dari Wahabisme ke Global Salafisme

OpenAIRE

Rofhani Rofhani

2016-01-01

The movement of Salafism constitutes part of the Islamic history of fundamentalism. They call their self as Salafis, who etymologically means “what had passed through and gone before” or “the outdistancing group”. The appearance of Global-Salafism apparently starts from the will of coming back to the past, which is the period of as-Salaf ash-S{âlih}. In the next development, it had to deal with the shifting perspective from theological nuance into political movement (Jihad-Salafism) which wel...

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African Journals Online (AJOL)

Conclusion: This study showed initial evidence of the use of plant materials by ..... Ocimum gratissimum L. Esrou,Deveti. 1197FDS/UL /3892. FDS/UL. 0,04. WP ..... properties of plant extracts have been widely shown in several studies(Kim et ...

Neurotoxic effects of oxygen in hyperbaric environment: A case report

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Rabrenović Milorad

2015-01-01

Full Text Available Introduction. Oxygen is an essential element of life in aerobic organisms. However, if not controlled, inhalation of oxygen under increased pressure in conditions of hyperbaric oxygen therapy can lead to serious damage and even death. Case report. We presented a 20-year-old male who had begun exhibiting symptoms of epilepsy during diving test in a hyperbaric chamber while inhaling 100% oxygen. He was immediately taken off oxygen mask and started breathing air and began rapid decompression. He lost consciousness, began foaming at the mouth, and had a series of tonic spasms. The patient was previously completely healthy and not on any medications. He was admitted for emergency treatment in our hospital, where he was treated for epilepsy. On admission, he complained of muscle and joint pain, and had erythematous changes on the forehead, neck and chest. All these changes occurred after leaving the hyperbaric chamber. Bloodwork revealed leukocytosis with neutrophil (Leukocytosis 16.0 ´ 109/L (reference values 4.00-11.00 ´ 109/L, Neutrophili 13 ´ 109/L (reference values 1.9-8.0 ´ 109/L, with elevated enzymes aspartate aminotransferase (AST 56 U/L (reference values 0-37 U/L, alanin aminotransferase (ALT 59 U /L, (reference values 25-65 U/L, creatine kinase (CK 649 U/L, (reference values 32-300 U /L, lactate dehydrogenase (LDH 398 U/L (reference values 85- 227 U/L. Because of pain and his condition we began treatment in a hyperbaric chamber at a pressure of 2.0 ATA for 70 minutes, resulting in a reduction of symptoms and objective recovery of the patient. Within 24 h, repeated laboratory tests showed a reduction of leukocytosis (13 ´ 109/L and neutrophils (7.81 ´ 109/L, and the gradual reduction of the enzymes AST (47 U/L, ALT (50 U/L, CK (409 U/L, LDH (325 U/L. Since head CT and EEG were normal, epilepsy diagnosis was ruled out. This fact, along with medical tests, facilitated the differential diagnosis and confirmed that this was a case of

Properties of virion transactivator proteins encoded by primate cytomegaloviruses

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Barry Peter A

2009-05-01

Full Text Available Abstract Background Human cytomegalovirus (HCMV is a betaherpesvirus that causes severe disease in situations where the immune system is immature or compromised. HCMV immediate early (IE gene expression is stimulated by the virion phosphoprotein pp71, encoded by open reading frame (ORF UL82, and this transactivation activity is important for the efficient initiation of viral replication. It is currently recognized that pp71 acts to overcome cellular intrinsic defences that otherwise block viral IE gene expression, and that interactions of pp71 with the cell proteins Daxx and ATRX are important for this function. A further property of pp71 is the ability to enable prolonged gene expression from quiescent herpes simplex virus type 1 (HSV-1 genomes. Non-human primate cytomegaloviruses encode homologs of pp71, but there is currently no published information that addresses their effects on gene expression and modes of action. Results The UL82 homolog encoded by simian cytomegalovirus (SCMV, strain Colburn, was identified and cloned. This ORF, named S82, was cloned into an HSV-1 vector, as were those from baboon, rhesus monkey and chimpanzee cytomegaloviruses. The use of an HSV-1 vector enabled expression of the UL82 homologs in a range of cell types, and permitted investigation of their abilities to direct prolonged gene expression from quiescent genomes. The results show that all UL82 homologs activate gene expression, and that neither host cell type nor promoter target sequence has major effects on these activities. Surprisingly, the UL82 proteins specified by non-human primate cytomegaloviruses, unlike pp71, did not direct long term expression from quiescent HSV-1 genomes. In addition, significant differences were observed in the intranuclear localization of the UL82 homologs, and in their effects on Daxx. Strikingly, S82 mediated the release of Daxx from nuclear domain 10 substructures much more rapidly than pp71 or the other proteins tested. All

RNA interference inhibits herpes simplex virus type 1 isolated from saliva samples and mucocutaneous lesions.

Science.gov (United States)

Silva, Amanda Perse da; Lopes, Juliana Freitas; Paula, Vanessa Salete de

2014-01-01

The aim of this study was to evaluate the use of RNA interference to inhibit herpes simplex virus type-1 replication in vitro. For herpes simplex virus type-1 gene silencing, three different small interfering RNAs (siRNAs) targeting the herpes simplex virus type-1 UL39 gene (sequence si-UL 39-1, si-UL 39-2, and si-UL 39-3) were used, which encode the large subunit of ribonucleotide reductase, an essential enzyme for DNA synthesis. Herpes simplex virus type-1 was isolated from saliva samples and mucocutaneous lesions from infected patients. All mucocutaneous lesions' samples were positive for herpes simplex virus type-1 by real-time PCR and by virus isolation; all herpes simplex virus type-1 from saliva samples were positive by real-time PCR and 50% were positive by virus isolation. The levels of herpes simplex virus type-1 DNA remaining after siRNA treatment were assessed by real-time PCR, whose results demonstrated that the effect of siRNAs on gene expression depends on siRNA concentration. The three siRNA sequences used were able to inhibit viral replication, assessed by real-time PCR and plaque assays and among them, the sequence si-UL 39-1 was the most effective. This sequence inhibited 99% of herpes simplex virus type-1 replication. The results demonstrate that silencing herpes simplex virus type-1 UL39 expression by siRNAs effectively inhibits herpes simplex virus type-1 replication, suggesting that siRNA based antiviral strategy may be a potential therapeutic alternative. Copyright © 2014. Published by Elsevier Editora Ltda.

Simulating Various Terrestrial and Uav LIDAR Scanning Configurations for Understory Forest Structure Modelling

Science.gov (United States)

Hämmerle, M.; Lukač, N.; Chen, K.-C.; Koma, Zs.; Wang, C.-K.; Anders, K.; Höfle, B.

2017-09-01

Information about the 3D structure of understory vegetation is of high relevance in forestry research and management (e.g., for complete biomass estimations). However, it has been hardly investigated systematically with state-of-the-art methods such as static terrestrial laser scanning (TLS) or laser scanning from unmanned aerial vehicle platforms (ULS). A prominent challenge for scanning forests is posed by occlusion, calling for proper TLS scan position or ULS flight line configurations in order to achieve an accurate representation of understory vegetation. The aim of our study is to examine the effect of TLS or ULS scanning strategies on (1) the height of individual understory trees and (2) understory canopy height raster models. We simulate full-waveform TLS and ULS point clouds of a virtual forest plot captured from various combinations of max. 12 TLS scan positions or 3 ULS flight lines. The accuracy of the respective datasets is evaluated with reference values given by the virtually scanned 3D triangle mesh tree models. TLS tree height underestimations range up to 1.84 m (15.30 % of tree height) for single TLS scan positions, but combining three scan positions reduces the underestimation to maximum 0.31 m (2.41 %). Combining ULS flight lines also results in improved tree height representation, with a maximum underestimation of 0.24 m (2.15 %). The presented simulation approach offers a complementary source of information for efficient planning of field campaigns aiming at understory vegetation modelling.

SIMULATING VARIOUS TERRESTRIAL AND UAV LIDAR SCANNING CONFIGURATIONS FOR UNDERSTORY FOREST STRUCTURE MODELLING

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M. Hämmerle

2017-09-01

Full Text Available Information about the 3D structure of understory vegetation is of high relevance in forestry research and management (e.g., for complete biomass estimations. However, it has been hardly investigated systematically with state-of-the-art methods such as static terrestrial laser scanning (TLS or laser scanning from unmanned aerial vehicle platforms (ULS. A prominent challenge for scanning forests is posed by occlusion, calling for proper TLS scan position or ULS flight line configurations in order to achieve an accurate representation of understory vegetation. The aim of our study is to examine the effect of TLS or ULS scanning strategies on (1 the height of individual understory trees and (2 understory canopy height raster models. We simulate full-waveform TLS and ULS point clouds of a virtual forest plot captured from various combinations of max. 12 TLS scan positions or 3 ULS flight lines. The accuracy of the respective datasets is evaluated with reference values given by the virtually scanned 3D triangle mesh tree models. TLS tree height underestimations range up to 1.84 m (15.30 % of tree height for single TLS scan positions, but combining three scan positions reduces the underestimation to maximum 0.31 m (2.41 %. Combining ULS flight lines also results in improved tree height representation, with a maximum underestimation of 0.24 m (2.15 %. The presented simulation approach offers a complementary source of information for efficient planning of field campaigns aiming at understory vegetation modelling.

Diagnostic value of sputum adenosine deaminase (ADA) level in pulmonary tuberculosis.

Science.gov (United States)

Binesh, Fariba; Jalali, Hadi; Zare, Mohammad Reza; Behravan, Farhad; Tafti, Arefeh Dehghani; Behnaz, Fatemah; Tabatabaee, Mohammad; Shahcheraghi, Seyed Hossein

2016-06-01

Tuberculosis is still a considerable health problem in many countries. Rapid diagnosis of this disease is important, and adenosine deaminase (ADA) has been used as a diagnostic test. The aim of this study was to assess the diagnostic value of ADA in the sputum of patients with pulmonary tuberculosis. The current study included 40 patients with pulmonary tuberculosis (culture positive, smear ±) and 42 patients with non tuberculosis pulmonary diseases (culture negative). ADA was measured on all of the samples. The median value of ADA in non-tuberculosis patients was 2.94 (4.2) U/L and 4.01 (6.54) U/L in tuberculosis patients, but this difference was not statistically significant (p=0.100). The cut-off point of 3.1 U/L had a sensitivity of 61% and a specificity of 53%, the cut-off point of 2.81 U/L had a sensitivity of 64% and a specificity of 50% and the cut-off point of 2.78 U/L had a sensitivity of 65% and a specificity of 48%. The positive predictive values for cut-off points of 3.1, 2.81 and 2.78 U/L were 55.7%, 57.44% and 69.23%, respectively. The negative predictive values for the abovementioned cut-off points were 56.75%, 57.14% and 55.88%, respectively. Our results showed that sputum ADA test is neither specific nor sensitive. Because of its low sensitivity and specificity, determination of sputum ADA for the diagnosis of pulmonary tuberculosis is not recommended.

"Podelis ulõbkoju svojei..." / Vitali Katuntsev

Index Scriptorium Estoniae

Katuntsev, Vitali

2006-01-01

Rahvusvahelisel noortepäeval 12. aug. toimus Narva Laste Loomingu Maja territooriumil teatraliseeritud tänavaetendus Street Theatre 2006, mis kandis pealkirja "100 protsenti positiivsust". Lavastuse valmistasid ette Narva Laste Loomingu Maja teater "16 komnata" ja Jõhvi kultuurikeskuse teatritrupp

Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling

NARCIS (Netherlands)

Zeev-Ben-Mordehai, Tzviya; Weberruss, Marion; Lorenz, Michael; Cheleski, Juliana; Hellberg, Teresa; Whittle, Cathy; El Omari, Kamel; Vasishtan, Daven; Dent, Kyle C.; Harlos, Karl; Franzke, Kati; Hagen, Christoph; Klupp, Barbara G.; Antonin, Wolfram; Mettenleiter, Thomas C.; Gruenewald, Kay

2015-01-01

Although nucleo-cytoplasmic transport is typically mediated through nuclear pore complexes, herpesvirus capsids exit the nucleus via a unique vesicular pathway. Together, the conserved herpesvirus proteins pUL31 and pUL34 form the heterodimeric nuclear egress complex (NEC), which, in turn, mediates

Previous Traumatic Life Events versus Course and Effectiveness of PTSD Therapy in Veterans of Polish Military Contingents

Science.gov (United States)

2011-04-01

Combat Stress ul.Szaserow 128 04-141 Warszawa POLAND E-mail: maciekzbyszewski@yahoo.com; ilnickis@wim.mil.pl ABSTRACT The goal of the paper...Institute, Department of Psychiatry and Combat Stress ul.Szaserow 128 04-141 Warszawa Poland 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING

Khattab (1969-2002)

Science.gov (United States)

2015-02-01

of a great cause that will leave you immortal in Paradise . And be aware not to die for the cause of an unknown matter which might end in a bad way... side of Panj River.30 Although the “river was [like] a wild beast and crossing it was jihad in itself,”31...and his group chose to station themselves on the Afghan side of the river and to cross the river back and forth each time they wanted to carry out an

Environmental Assessment of Lead at Camp Edwards, Massachusetts, Small Arms Ranges

Science.gov (United States)

2007-08-01

hydroxyapatite [Pb5(PO4)3(OH)], and lead oxyphosphate [Pb4O(PO4)2]. Lead phosphate minerals, in particular, are so sparingly soluble, thermodynamic...M ea n XR F Le ad Pr of ile R es ul ts (m g/ kg ) 1 -1 0 in ch es bg s M ea n XR F Le ad Pr of ile R es ul ts (m g/ kg ) 1 0- 20 in...ch es bg s M ea n XR F Le ad Pr of ile R es ul ts (m g/ kg ) 2 0- 30 in ch es

Use of seaweed Ulva lactuca for water bioremediation and as feed additive for white shrimp Litopenaeus vannamei

Directory of Open Access Journals (Sweden)

Regina Elizondo-González

2018-03-01

Full Text Available Two experimental feeding trials were conducted during four weeks to evaluate the use of Ulva lactuca in shrimp culture: (1 for wastewater bioremediation, and (2 using different inclusion levels of U. lactuca meal in shrimp feed. In feeding trial 1, shrimp reared under seaweed U. lactuca water exchange in a re-circulation system (SWE resulted in similar growth and feed utilization as shrimp reared with clean water exchange (CWE. Shrimp under no water exchange (NWE resulted in significant lower growth and higher feed conversion rate (FCR compared to the other treatments (p  0.05. In feeding trial 2, U. lactuca biomass produced by wastewater bioremediation in SWE treatment were dried and ground to formulate diets containing 0, 1, 2, and 3% U. lactuca meal (0UL, 1UL, 2UL, and 3UL. Shrimp fed the 3 UL diet resulted in a significant (p < 0.05 improvement of growth and FCR, and enhanced whole shrimp lipid and carotenoid content by 30 and 60%, respectively, compared to control diet. Seaweed U. lactuca is suggested as a desirable species for wastewater bioremediation in integrated aquaculture systems, and its meal as a good feed additive for farmed shrimp.

Vulnerability Assessment of Rural Households to Urmia Lake Drying (the Case of Shabestar Region

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Rasoul Maleki

2018-06-01

Full Text Available One of the most important environmental problems in Iran is the destruction and drying of Urmia Lake (UL. UL is one of the main causes of suitable weather for agricultural boom and tourist attraction and it should be considered that the villagers exposed to UL drying have a strong dependence on vulnerable resources such as water, air, soil and plants for their livelihoods and have low adaptive capacity with this crisis for reasons such as poverty, lack of awareness and lack of infrastructure. This study was designed to evaluate the vulnerability of rural households to UL drying in the Shabestar region. The vulnerability was calculated based on Intergovernmental Panel on Climate Change (IPCC definition and using vulnerability index (VI. Research population included rural households of Shabestar region (N = 19,249 and about 347 households were selected as the research sample using multistage cluster sampling technique. Results showed that the average score of respondents was 0.455 (moderate in exposure, 0.359 (moderate to low in sensitivity, 0.404 (moderate to low in adaptive capacity and finally, the vulnerability index (VI was 0.470 (range of 0 to 1. 12.8% of households had low, 70.5% had medium and 16.7% had high vulnerability towards UL drying.

The first genome sequence of a metatherian herpesvirus: Macropodid herpesvirus 1.

Science.gov (United States)

Vaz, Paola K; Mahony, Timothy J; Hartley, Carol A; Fowler, Elizabeth V; Ficorilli, Nino; Lee, Sang W; Gilkerson, James R; Browning, Glenn F; Devlin, Joanne M

2016-01-22

While many placental herpesvirus genomes have been fully sequenced, the complete genome of a marsupial herpesvirus has not been described. Here we present the first genome sequence of a metatherian herpesvirus, Macropodid herpesvirus 1 (MaHV-1). The MaHV-1 viral genome was sequenced using an Illumina MiSeq sequencer, de novo assembly was performed and the genome was annotated. The MaHV-1 genome was 140 kbp in length and clustered phylogenetically with the primate simplexviruses, sharing 67% nucleotide sequence identity with Human herpesviruses 1 and 2. The MaHV-1 genome contained 66 predicted open reading frames (ORFs) homologous to those in other herpesvirus genomes, but lacked homologues of UL3, UL4, UL56 and glycoprotein J. This is the first alphaherpesvirus genome that has been found to lack the UL3 and UL4 homologues. We identified six novel ORFs and confirmed their transcription by RT-PCR. This is the first genome sequence of a herpesvirus that infects metatherians, a taxonomically unique mammalian clade. Members of the Simplexvirus genus are remarkably conserved, so the absence of ORFs otherwise retained in eutherian and avian alphaherpesviruses contributes to our understanding of the Alphaherpesvirinae. Further study of metatherian herpesvirus genetics and pathogenesis provides a unique approach to understanding herpesvirus-mammalian interactions.

Pengembangan Model Bimbingan Kelompok Berbasis Islami untuk Meningkatkan Kecerdasan Emosional Siswa

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ningsih fadhilah

2017-06-01

Full Text Available This article examines the model of group guidance development that is effective in improving the emotional intelligence of senior high school students. This research used educational research and development method. The sample was chosen by purposive sampling to one group of 10 students. The result of this research is Islamic-based group guidance model. The Islamic group-based guidance model developed is a process of providing assistance by counselors to individual through a group atmosphere based on Islamic values in al-qur'an and hadith, enabling each member to learn to participate actively by utilizing the thought and experience of group members. The result of model implementation shows that the guidance of Islamic-based group proved effective in improving students' emotional intelligence. This increase occurs in all aspects of emotional intelligence. Wilcoxon statistical test result shows probability value below 0.05 (0.0025 <0.05, means that the guidance of Islamic-based group effective to improve students' emotional intelligence.

Komodifikasi Pariwisata Halal NTB dalam Promosi Destinasi Wisata Islami di Indonesia

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Hafizah Awalia

2017-03-01

Full Text Available Halal tourism destination becomes the new brand for West Nusa Tenggara. Strong local ethnic and religious plurality obtain halal tourism label. It is important to assess if the government saw the domination of the discourse object of power through the economic and tourism sectors. Therefore, this discourse halal tourism can be evaluated using the perspective of post-modern social theory Michael Foucault discourse and power: the power elite that is capable of creating a new discourse (halal tourism to strengthen its political dominance. Then, using the perspective of Baudrillard's theory of the emergence of consumerist society in NTB as a result of capital commodification and domination of the capitalists.   Keywords: Commodification, Discourse, Tourism, Halal

PENANAMAN NILAI-NILAI DASAR ISLAMI ANAK USIA DINI PADA MASYARAKAT PERKOTAAN

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Isyatul Mardiyati

2015-06-01

Full Text Available Negative Social phenomena in urban society due to changes in lifestyle, social interaction, and changes in social systems have led to problems in many aspects of life. The social problems indicate that urban community is going through a phase of ‘demoralization’ as a result of social changes that are not in line with the Islamic basic values and other norms. The increasing cases of crime in urban areas in terms of quality and quantity, such as corruption, fraud, theft, assault, murder, etc. indicate that the quality of the character and behavior of individuals or groups are still low, resulting from insufficient religious education and norms they receive from an early age. In this light, the Kindergarten or Early Childhood Education plays a very important role in instilling basic Islamic values in children from an early age. The efforts can be made through a series of activities of ‘play and learn’ to actualize Islamic values in everyday life. These activities are expected to achieve a better generation in terms of mental and intellectual capacities, having noble character and strong faith as well as piety to Allah. In addition, through instillation of basic Islamic values from an early age, we will have a new generation of Muslims who act as agents of change that bring about the glory of Islam in the modern era.

Deradicalization or Disengagement : A Framework for Encouraging Jihad Abandonment

Science.gov (United States)

2016-06-10

antithetical to its ruggedly individualistic culture . Family accountability in maintaining disengagement of a former radical is a remarkable method...terrorist organization seeking national self-determination may be satisfied with a local political settlement granting more autonomy or some other sort...prisoner, once released, does not return to violence. Saudi culture places high value on family responsibility, as evident by concepts of family honor.36

Gender Jihad: Muslim Women, Islamic Jurisprudence, and Women's Rights

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Melanie P. Mejia

2007-06-01

Full Text Available Muslim women's rights have been a topic of discussion and debate over the past few decades, and with a good reason. Islamic Law (Shariah is considered by many as patriarchal and particularly oppressive to women, and yet there are also others-Muslim women-who have rigorously defended their religion by claiming that Islam is the guarantor par excellence of women's rights. A big question begs to be answered: is Islam particularly oppressive to women?The Qur'an has addressed women's issues fourteen hundred years ago by creating certain reforms to improve the status of women; however, these reforms do not seem to be practiced in Muslim societies today.1 How is this so? I contend that Islam, as revealed to Muhammad, is not oppressive to women; rather, its interpretation, in so far as it is enacted in the family laws and everyday living, is patriarchal and hence needs to be examined.2 The goal of this work is to discuss what the Qur'an says about certain problems which gravely affect Muslim women, specifically: 1. gender equality 2. polygamy 3. divorce and the concept of nushuz

Deradicalization or Disengagement : A Framework for Encouraging Jihad Abandonment

Science.gov (United States)

2016-06-10

resulted in entire group disengagement, while the German HAYAT Program and Saudi Counseling Program seek individual de-radicalization/disengagement... Counseling Y Optional N/A Y Y Family Counseling N Y N Y Y Practical Support Measures Y Y Y Y Y Disengage Guarantee – Type Y - Family N Y – Group N...disengagement. The U.S. could easily support religious counseling in de-radicalization programs in partner nations overseas. Group or Individual Programs

CONFLICT, JIHAD, AND RELIGIOUS IDENTITY IN MALUKU, EASTERN INDONESIA

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Badrus Sholeh

2008-02-01

Full Text Available The collapse of Suharto’s New Order is a starting point of the quest of religious identity for Indonesian Muslims. A lot of radical groups are founded under the umbrella of liberty and democracy. However, many of them have destroyed the structure of democracy and multicultural society. Conflicts of Maluku (and Poso (1999-2003 are the best local context of how religious groups (Muslims and Christians fighted severely in the name of God. The conflict is also a good case to understand the weakening of state and the involvements of military (para-military forces in instigating the conflicts, which impacted to thousands people killed, and destroyed the ethnic and religious harmony in the region. This paper will analyse the conflicts of Maluku and compare it to other religious conflicts in Poso, Central Sulawesi and ethnic conflicts in West Kalimantan, Southern Thailand and Southern Philippines. I argue the growth of local nationalism and unstability of States in Southeast Asian regions brings the rise of civil society and paramilitary forces, which challenges the entities of harmony, peace and multiculturalism in the region.

Video games, terrorism, and ISIS’s Jihad 3.0

NARCIS (Netherlands)

A.K. Al-Rawi (Ahmed)

2016-01-01

textabstractThis study discusses different media strategies followed by the Islamic State in Iraq and Syria (ISIS). In particular, the study attempts to understand the way ISIS’s video game that is called “Salil al-Sawarem” (The Clanging of the Swords) has been received by the online Arab public.

Interview with Ramadan Shallah, Secretary General, Palestinian Islamic Jihad

Directory of Open Access Journals (Sweden)

Scott Atran

2010-11-01

Full Text Available On December 14-16, 2009, a delegation from the World Federation of Scientists, including the authors, traveled to Damascus to interview senior Syrian and Palestinian leaders from Syria and various Palestinian factions, including the members of the leadership of Hamas and the Popular Front for the Liberation of Palestine. The objective was to gain insight from field interviews into how to further advance scientific understanding of cultural and political conflict in order to create new theoretical and practical frameworks for negotiation and cooperation.

Partial functional complementation between human and mouse cytomegalovirus chemokine receptor homologues

DEFF Research Database (Denmark)

Farrell, Helen E; Abraham, Alexander M; Cardin, Rhonda D

2011-01-01

The human cytomegalovirus (CMV) proteins US28 and UL33 are homologous to chemokine receptors (CKRs). Knockout of the mouse CMV M33 protein (UL33 homologue) results in substantial attenuation of salivary gland infection/replication and reduced efficiency of reactivation from tissue explants. M33-m...

Precarisation, Social Work, and Social Ethics

DEFF Research Database (Denmark)

Zeller, Jörg

2011-01-01

Prækarisering af arbejds- og livsforhold stiller forøgede krav til socialarbejde og stiller socialarbejdere for individuelt uløselige dilemmaer.......Prækarisering af arbejds- og livsforhold stiller forøgede krav til socialarbejde og stiller socialarbejdere for individuelt uløselige dilemmaer....

Fighting fires... with science

CERN Document Server

Anaïs Schaeffer

2016-01-01

CERN firefighters are working with a research centre in the United States to develop more effective firefighting techniques.   One of the UL FSRI’s model houses is set alight... in the interest of science. (Photo: ©UL FSRI) For around ten years, the Underwriters Laboratories Firefighter Safety Research Institute (UL FSRI) has been carrying out scientific research on the various techniques used by firefighters in the United States and around the world. This research has focused on evaluating the effectiveness and safety of current practices worldwide with the aim of developing even better techniques. In many cases the research has shown that a combination of techniques gives the best results. The interiors of the model houses are fully furnished. (Photo: ©UL FSRI) Art Arnalich, who has worked with fire brigades in the United States and Europe and is now a member of CERN’s Fire Brigade, has actively participated in this research since 2013. His knowledge of ...

Acute and subacute toxicological evaluation of the aerial extract of Monsonia angustifolia E. Mey. ex. A. Rich in Wistar rats

CSIR Research Space (South Africa)

Afolayan, AJ

2016-01-01

Full Text Available .67 ± 1.51 59.67 ± 1.53 58.67 ± 1.51 57.33 ± 1.51 Total bilirubin (𝜇mol/L) 7.00 ± 0.65 7.32 ± 0.00 7.37 ± 0.08 7.50 ± 0.54 AST (U/L) 140.33 ± 1.79 139.33 ± 1.15 141.33 ± 1.08 144.65 ± 1.71 ALT (U/L) 61.67 ± 1.02 62.67 ± 1.29 63.00 ± 1.44 63.67 ± 1.72 ALP... (U/L) 380.30 ± 1.53 382.30 ± 1.15 385.00 ± 1.58 383.30 ± 1.00 GGT (U/L) 1.67 ± 0.53 1.70 ± 0.00 1.70 ± 0.00 1.67 ± 0.15 Data are means ± SEM (𝑛 = 6). Values not carrying superscripts are not significantly different (𝑝 > 0.05) from the control. AST...

Comparison between Flail Arm Syndrome and Upper Limb Onset Amyotrophic Lateral Sclerosis: Clinical Features and Electromyographic Findings.

Science.gov (United States)

Yoon, Byung-Nam; Choi, Seong Hye; Rha, Joung-Ho; Kang, Sa-Yoon; Lee, Kwang-Woo; Sung, Jung-Joon

2014-09-01

Flail arm syndrome (FAS), an atypical presentation of amyotrophic lateral sclerosis (ALS), is characterized by progressive, predominantly proximal, weakness of upper limbs, without involvement of the lower limb, bulbar, or respiratory muscles. When encountering a patient who presents with this symptomatic profile, possible diagnoses include upper limb onset ALS (UL-ALS), and FAS. The lack of information regarding FAS may make differential diagnosis between FAS and UL-ALS difficult in clinical settings. The aim of this study was to compare clinical and electromyographic findings from patients diagnosed with FAS with those from patients diagnosed with UL-ALS. To accomplish this, 18 patients with FAS and 56 patients with UL-ALS were examined. Significant differences were observed between the 2 groups pertaining to the rate of fasciculation, patterns of predominantly affected muscles, and the Medical Research Council scale of the weakest muscle. The presence of upper motor neuron signs and lower motor neuron involvement evidenced through electromyography showed no significant between-group differences.

Load Dependency of Postural Control--Kinematic and Neuromuscular Changes in Response to over and under Load Conditions.

Science.gov (United States)

Ritzmann, Ramona; Freyler, Kathrin; Weltin, Elmar; Krause, Anne; Gollhofer, Albert

2015-01-01

Load variation is associated with changes in joint torque and compensatory reflex activation and thus, has a considerable impact on balance control. Previous studies dealing with over (OL) and under loading (UL) used water buoyancy or additional weight with the side effects of increased friction and inertia, resulting in substantially modified test paradigms. The purpose of this study was to identify gravity-induced load dependency of postural control in comparable experimental conditions and to determine the underlying neuromuscular mechanisms. Balance performance was recorded under normal loading (NL, 1 g), UL (0.16 g 0.38 g) and OL (1.8 g) in monopedal stance. Center of pressure (COP) displacement and frequency distribution (low 0.15-0.5 Hz (LF), medium 0.5-2 Hz (MF), high 2-6 Hz (HF)) as well as ankle, knee and hip joint kinematics were assessed. Soleus spinal excitability was determined by H/M-recruitment curves (H/M-ratios). Compared to NL, OL caused an increase in ankle joint excursion, COP HF domain and H/M-ratio. Concomitantly, hip joint excursion and COP LF decreased. Compared to NL, UL caused modulations in the opposite direction: UL decreased ankle joint excursions, COP HF and H/M-ratio. Collaterally, hip joint excursion and COP LF increased. COP was augmented both in UL and in OL compared to NL. Subjects achieved postural stability in OL and UL with greater difficulty compared to NL. Reduced postural control was accompanied by modified balance strategies and compensatory reflex activation. With increasing load, a shift from hip to ankle strategy was observed. Accompanying, COP frequency distribution shifted from LF to HF and spinal excitability was enhanced. It is suggested that in OL, augmented ankle joint torques are compensated by quick reflex-induced postural reactions in distal muscles. Contrarily, UL is associated with diminished joint torques and thus, postural equilibrium may be controlled by the proximal segments to adjust the center of

Load Dependency of Postural Control - Kinematic and Neuromuscular Changes in Response to over and under Load Conditions

Science.gov (United States)

Ritzmann, Ramona; Freyler, Kathrin; Weltin, Elmar; Krause, Anne; Gollhofer, Albert

2015-01-01

Introduction Load variation is associated with changes in joint torque and compensatory reflex activation and thus, has a considerable impact on balance control. Previous studies dealing with over (OL) and under loading (UL) used water buoyancy or additional weight with the side effects of increased friction and inertia, resulting in substantially modified test paradigms. The purpose of this study was to identify gravity-induced load dependency of postural control in comparable experimental conditions and to determine the underlying neuromuscular mechanisms. Methods Balance performance was recorded under normal loading (NL, 1g), UL (0.16g; 0.38g) and OL (1.8g) in monopedal stance. Center of pressure (COP) displacement and frequency distribution (low 0.15-0.5Hz (LF), medium 0.5-2Hz (MF), high 2-6Hz (HF)) as well as ankle, knee and hip joint kinematics were assessed. Soleus spinal excitability was determined by H/M-recruitment curves (H/M-ratios). Results Compared to NL, OL caused an increase in ankle joint excursion, COP HF domain and H/M-ratio. Concomitantly, hip joint excursion and COP LF decreased. Compared to NL, UL caused modulations in the opposite direction: UL decreased ankle joint excursions, COP HF and H/M-ratio. Collaterally, hip joint excursion and COP LF increased. COP was augmented both in UL and in OL compared to NL. Conclusion Subjects achieved postural stability in OL and UL with greater difficulty compared to NL. Reduced postural control was accompanied by modified balance strategies and compensatory reflex activation. With increasing load, a shift from hip to ankle strategy was observed. Accompanying, COP frequency distribution shifted from LF to HF and spinal excitability was enhanced. It is suggested that in OL, augmented ankle joint torques are compensated by quick reflex-induced postural reactions in distal muscles. Contrarily, UL is associated with diminished joint torques and thus, postural equilibrium may be controlled by the proximal

Clinical assessment and three-dimensional movement analysis: An integrated approach for upper limb evaluation in children with unilateral cerebral palsy.

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Lisa Mailleux

Full Text Available The clinical application of upper limb (UL three-dimensional movement analysis (3DMA in children with unilateral cerebral palsy (uCP remains challenging, despite its benefits compared to conventional clinical scales. Moreover, knowledge on UL movement pathology and how this relates to clinical parameters remains scarce. Therefore, we investigated UL kinematics across different manual ability classification system (MACS levels and explored the relation between clinical and kinematic parameters in children with uCP.Fifty children (MACS: I = 15, II = 26, III = 9 underwent an UL evaluation of sensorimotor impairments (grip force, muscle strength, muscle tone, two-point discrimination, stereognosis, bimanual performance (Assisting Hand Assessment, AHA, unimanual capacity (Melbourne Assessment 2, MA2 and UL-3DMA during hand-to-head, hand-to-mouth and reach-to-grasp tasks. Global parameters (Arm Profile Score (APS, duration, (timing of maximum velocity, trajectory straightness and joint specific parameters (angles at task endpoint, ROM and Arm Variable Scores (AVS were extracted. The APS and AVS refer respectively to the total amount of movement pathology and movement deviations of wrist, elbow, shoulder, scapula and trunk.Longer movement durations and increased APS were found with higher MACS-levels (p<0.001. Increased APS was also associated with more severe sensorimotor impairments (r = -0.30-(-0.73 and with lower AHA and MA2-scores (r = -0.50-(-0.86. For the joint specific parameters, stronger movement deviations distally were significantly associated with increased muscle weakness (r = -0.32-(-0.74 and muscle tone (r = 0.33-(-0.61; proximal movement deviations correlated only with muscle weakness (r = -0.35-0.59. Regression analysis exposed grip force as the most important predictor for the variability in APS (p<0.002.We found increased movement pathology with increasing MACS-levels and demonstrated the adverse impact of especially muscle weakness

Clinical assessment and three-dimensional movement analysis: An integrated approach for upper limb evaluation in children with unilateral cerebral palsy.

Science.gov (United States)

Mailleux, Lisa; Jaspers, Ellen; Ortibus, Els; Simon-Martinez, Cristina; Desloovere, Kaat; Molenaers, Guy; Klingels, Katrijn; Feys, Hilde

2017-01-01

The clinical application of upper limb (UL) three-dimensional movement analysis (3DMA) in children with unilateral cerebral palsy (uCP) remains challenging, despite its benefits compared to conventional clinical scales. Moreover, knowledge on UL movement pathology and how this relates to clinical parameters remains scarce. Therefore, we investigated UL kinematics across different manual ability classification system (MACS) levels and explored the relation between clinical and kinematic parameters in children with uCP. Fifty children (MACS: I = 15, II = 26, III = 9) underwent an UL evaluation of sensorimotor impairments (grip force, muscle strength, muscle tone, two-point discrimination, stereognosis), bimanual performance (Assisting Hand Assessment, AHA), unimanual capacity (Melbourne Assessment 2, MA2) and UL-3DMA during hand-to-head, hand-to-mouth and reach-to-grasp tasks. Global parameters (Arm Profile Score (APS), duration, (timing of) maximum velocity, trajectory straightness) and joint specific parameters (angles at task endpoint, ROM and Arm Variable Scores (AVS)) were extracted. The APS and AVS refer respectively to the total amount of movement pathology and movement deviations of wrist, elbow, shoulder, scapula and trunk. Longer movement durations and increased APS were found with higher MACS-levels (pMA2-scores (r = -0.50-(-0.86)). For the joint specific parameters, stronger movement deviations distally were significantly associated with increased muscle weakness (r = -0.32-(-0.74)) and muscle tone (r = 0.33-(-0.61)); proximal movement deviations correlated only with muscle weakness (r = -0.35-0.59). Regression analysis exposed grip force as the most important predictor for the variability in APS (p<0.002). We found increased movement pathology with increasing MACS-levels and demonstrated the adverse impact of especially muscle weakness. The lower correlations suggest that 3DMA provides additional information regarding UL motor function, particularly for

Load Dependency of Postural Control--Kinematic and Neuromuscular Changes in Response to over and under Load Conditions.

Directory of Open Access Journals (Sweden)

Ramona Ritzmann

Full Text Available Load variation is associated with changes in joint torque and compensatory reflex activation and thus, has a considerable impact on balance control. Previous studies dealing with over (OL and under loading (UL used water buoyancy or additional weight with the side effects of increased friction and inertia, resulting in substantially modified test paradigms. The purpose of this study was to identify gravity-induced load dependency of postural control in comparable experimental conditions and to determine the underlying neuromuscular mechanisms.Balance performance was recorded under normal loading (NL, 1 g, UL (0.16 g 0.38 g and OL (1.8 g in monopedal stance. Center of pressure (COP displacement and frequency distribution (low 0.15-0.5 Hz (LF, medium 0.5-2 Hz (MF, high 2-6 Hz (HF as well as ankle, knee and hip joint kinematics were assessed. Soleus spinal excitability was determined by H/M-recruitment curves (H/M-ratios.Compared to NL, OL caused an increase in ankle joint excursion, COP HF domain and H/M-ratio. Concomitantly, hip joint excursion and COP LF decreased. Compared to NL, UL caused modulations in the opposite direction: UL decreased ankle joint excursions, COP HF and H/M-ratio. Collaterally, hip joint excursion and COP LF increased. COP was augmented both in UL and in OL compared to NL.Subjects achieved postural stability in OL and UL with greater difficulty compared to NL. Reduced postural control was accompanied by modified balance strategies and compensatory reflex activation. With increasing load, a shift from hip to ankle strategy was observed. Accompanying, COP frequency distribution shifted from LF to HF and spinal excitability was enhanced. It is suggested that in OL, augmented ankle joint torques are compensated by quick reflex-induced postural reactions in distal muscles. Contrarily, UL is associated with diminished joint torques and thus, postural equilibrium may be controlled by the proximal segments to adjust the center of

Facile green synthesis of zinc oxide nanoparticles using Ulva lactuca seaweed extract and evaluation of their photocatalytic, antibiofilm and insecticidal activity.

Science.gov (United States)

Ishwarya, Ramachandran; Vaseeharan, Baskaralingam; Kalyani, Subramanian; Banumathi, Balan; Govindarajan, Marimuthu; Alharbi, Naiyf S; Kadaikunnan, Shine; Al-Anbr, Mohammed N; Khaled, Jamal M; Benelli, Giovanni

2018-01-01

The bioactivity of semiconductor nanocomplexes has been poorly studied in the field of pesticide science. In this research, the synthesis of zinc nanoparticles was accomplished through new effortless green chemistry process, using the Ulva lactuca seaweed extract as a reducing and capping agent. The production of U. lactuca-fabricated ZnO nanoparticles (Ul-ZnO Nps) was characterized by powder X-ray diffraction (XRD), UV-visible, Fourier transform infrared (FTIR) spectroscopy, selected area electron diffraction (SAED) analysis and transmission electron microscopy (TEM). The U. lactuca-fabricated ZnO NPs were tested for their photodegradative action against organic dyes, as well as for antibiofilm and larvicidal activities. The UV visible absorbance spectrum of Ul-ZnO NPs exhibited the absorbance band at 325nm and TEM highlighted average crystallite sizes of nanoparticles of 10-50nm. Methylene blue (MB) dye was efficiently corrupted under sunlight in presence of Ul-ZnO NPs. Excellent bactericidal activity was shown by the Ul-ZnO Nps on Gram positive (Bacillus licheniformis and Bacillus pumilis) and Gram negative (Escherichia coliand Proteus vulgaris) bacteria. High antibiofilm potential was noted under both dark and sunlight conditions. The impact of a single treatment with Ul-ZnO NPs on biofilm architecture was also analyzed by confocal laser scanning microscopy (CLSM) on both Gram positive and Gram negative bacteria. Moreover, Ul-ZnO NPs led to 100% mortality of Aedes aegypti fourth instar larvae at the concentration of 50μg/ml within 24h. The effects of ZnO nanoparticle-based treatment on mosquito larval morphology and histology were monitored. Overall, based on our results, we believe that the synthesis of multifunctional Ul-ZnO Nps using widely available seaweed products can be promoted as a potential eco-friendly option to chemical methods currently used for nanosynthesis of antimicrobials and insecticides. Copyright © 2017 Elsevier B.V. All rights reserved.

Distinct expression profile of HCMV encoded miRNAs in plasma from oral lichen planus patients.

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Ding, Meng; Wang, Xiang; Wang, Cheng; Liu, Xiaoshuang; Zen, Ke; Wang, Wenmei; Zhang, Chen-Yu; Zhang, Chunni

2017-06-07

Oral lichen planus (OLP) is a T cell-mediated autoimmune disease. The aetiology and molecular mechanisms of OLP remain unclear. Human cytomegalovirus (HCMV) infection is a causal factor in the development of various diseases, but the clinical relevance of HCMV in OLP has not been thoroughly investigated. In the present study, we firstly examined twenty-three HCMV-encoded microRNA (miRNA) expression profiles in plasma from training set that including 21 OLP patients and 18 healthy controls using RT-qPCR technology. Dysregulated miRNAs were subsequently confirmed in another larger cohort refereed as validation set consisting of 40 OLP patients and 33 healthy controls. HCMV DNA in peripheral blood leukocytes (PBLs) was also measured in an additional cohort of 13 OLP patients and 12 control subjects. Furthermore, bioinformatics analyses, luciferase reporter assay and western blotting were also performed to predict and verify the direct potential targets of HCMV-encoded miRNAs. The RT-qPCR results showed that the plasma levels of five HCMV-encoded miRNAs including hcmv-miR-UL112-3p, hcmv-miR-UL22a-5p, hcmv-miR-UL148d, hcmv-miR-UL36-5p and hcmv-miR-UL59 were significantly increased in OLP patients in both training and validation sets. HCMV DNA in PBLs was also significantly higher in OLP patients than in control subjects. Additionally, by using a combination of luciferase reporter assay and western blotting, we demonstrated that cytomegalovirus UL16-binding protein 1, a molecule that mediates the killing of virus-infected cells by natural killer cells, is a direct target of hcmv-miR-UL59. Our results demonstrate a distinct expression pattern of HCMV-encoded miRNAs in OLP patients, which may provide insight into the relationship between HCMV infection and OLP, and warrants additional study in the diagnosis and aetiology of OLP.

Coordinated leading and lagging strand DNA synthesis by using the herpes simplex virus 1 replication complex and minicircle DNA templates.

Science.gov (United States)

Stengel, Gudrun; Kuchta, Robert D

2011-01-01

The origin-specific replication of the herpes simplex virus 1 genome requires seven proteins: the helicase-primase (UL5-UL8-UL52), the DNA polymerase (UL30-UL42), the single-strand DNA binding protein (ICP8), and the origin-binding protein (UL9). We reconstituted these proteins, excluding UL9, on synthetic minicircular DNA templates and monitored leading and lagging strand DNA synthesis using the strand-specific incorporation of dTMP and dAMP. Critical features of the assays that led to efficient leading and lagging stand synthesis included high helicase-primase concentrations and a lagging strand template whose sequence resembled that of the viral DNA. Depending on the nature of the minicircle template, the replication complex synthesized leading and lagging strand products at molar ratios varying between 1:1 and 3:1. Lagging strand products (∼0.2 to 0.6 kb) were significantly shorter than leading strand products (∼2 to 10 kb), and conditions that stimulated primer synthesis led to shorter lagging strand products. ICP8 was not essential; however, its presence stimulated DNA synthesis and increased the length of both leading and lagging strand products. Curiously, human DNA polymerase α (p70-p180 or p49-p58-p70-p180), which improves the utilization of RNA primers synthesized by herpesvirus primase on linear DNA templates, had no effect on the replication of the minicircles. The lack of stimulation by polymerase α suggests the existence of a macromolecular assembly that enhances the utilization of RNA primers and may functionally couple leading and lagging strand synthesis. Evidence for functional coupling is further provided by our observations that (i) leading and lagging strand synthesis produce equal amounts of DNA, (ii) leading strand synthesis proceeds faster under conditions that disable primer synthesis on the lagging strand, and (iii) conditions that accelerate helicase-catalyzed DNA unwinding stimulate decoupled leading strand synthesis but not

Hizb ut-Tahrir in the press II: Exploring differences between academic discourses and editorial choices in Europe and Central Asia

Directory of Open Access Journals (Sweden)

Irina Volf

2015-04-01

Full Text Available This article analyzes academic discourses on Hizb ut-Tahrir al-Islami (HT in various disciplines, provides an overview of media frames applied to HT in German, British and Kyrgyz quality newspapers, and examines the differences between the conclusions of scholars and mass media representations of HT. The introductory section of the paper briefly presents a group of selected authors and texts, illustrates the importance of drawing parallels between academic and journalistic discourses on HT, and explains the choice of the countries used in the study. The methodological section specifies the questions, sources and methods of research. Finally, there is a detailed presentation and discussion of the findings, followed by a summary of the conclusions.

Islamizarea generației a doua.De la Europa all-inclusive la jihad (The second-generation islamization. From all-inclusive Europe to jihad

Directory of Open Access Journals (Sweden)

Georgeta CONDUR

2015-12-01

Full Text Available Starting from the summer of 2015, the massive arrival of asylum seekers in Europe opened a debate about the political, economical and security consequences of immigration in European Union. A hidden ideological conflict was transformed into a linguistic controversy: should the new-comers be named migrants or refugees? During time and development of the crisis, more and more journalists and political leaders switched from ‘refugees’ to ‘migrants’, as it became clear that many asylum seekers weren’t even from war zones. However, the main concern of the most people was related to potential security risks. An investigation into the November 13 attacks in Paris has already found that at least two of the terrorists used the Balkan route to arrive in France. But massive immigration could have further repercussions in not many years, if the hypothesis of a “second-generation islamization phenomenon”, somehow similar to Dole’s “second-generation indigenization”, is true. Having lower level needs in Maslow’s Hierarchy of Needs already satisfied, the children of the present Muslim migrants could seek to satisfy higher needs, as self-actualization, through religious identity of their parents and radicalization. Due to denial of the separation of religion and state in Islam, this could seriously threaten the Western secular state and cultural model. Being din wa dawla (religion and state, Islam is more than a religion; it is a hybrid we can call ‘relideology’, which seems to be quite attractive for young Muslims seeking self-actualization.

The Taliban in 2024

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Michael Semple

2014-11-01

Full Text Available Reacting to corruption and oppression in the Kandahar of 1994, the Taliban is seen as working with Sunni clerics to foster a shariat movement for advancing economic justice and (corporal punishment. Before long, the organization began substantially rewarding joiners, arming for jihad, and resisting international forces in Afghanistan. Now, with less foreign resources to fight the Taliban, the Kabul central government has unfinished business with its still-robust challengers. In the face of recent modernization in sectors such as education and media, the author details three plausible scenarios for the Taliban to maintain its core shariat mission. One scenario is for the Taliban to re-secure (through continued force its initial goal, viz., overall state power to promote and enforce shariat across urban as well as rural areas. Another possibility projects Afghanistan as operating a dualist system of separate zones, one for the Taliban's ‘liberated territory,’ the other for the rest of Afghanistan as governed by Kabul. Achieving scenario three would be formidable: it posits that Taliban leaders may be persuaded that their armed jihad has run its course and can profitably be disconnected from the Middle East's broader Islamic conflict. Conceivably, then, through accommodations with a shariat-accepting Kabul government, Taliban might be able to win buy-in for peace from its own military and its own fighting priests with their strong ties to Afghan communities in Pakistan.

POLITICAL ISLAM IN THE 21ST CENTURY

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Ferran Izquierdo Brichs

2011-04-01

Full Text Available Since the 1980s, political Islam or Islamism has created enormous concern both in the political media and the news media. The revolution in Iran in the late 1970s and the election victory by FIS in Algeria in the late 1980s represented two decisive points in the popular and ideological mobilisation by Islamist groups. Immediately after that, the civil war in Algeria and terrorist violence left their mark on the 1990s. The perception of Islamism today is still associated, in many cases, with the dynamics of the end of the past century, and with the jihadism of a few fundamentalist groups, without taking into account the fact that the majority of Islamist groups have undergone an enormous evolution, and that the context in which they are operating is also very different. As we will see, instead of the jihadism or the ideological radicalness of the past century, today’s political Islam is much better represented by the moderation (both ideological and in terms of political activity of Turkey’s AKP party, the Muslim Brotherhood in Egypt, Morocco’s PJD, Tunisia’s al-Nahdah and most of the parties and large groups. Central factors in this dynamic of moderation are, on one hand, the link between Islamist groups with regimes and, on the other, the claims for and acceptance of liberal democracy as a strategy in their political struggle.

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the Tolerable Upper Intake Level of vitamin D

DEFF Research Database (Denmark)

Tetens, Inge

Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to re-evaluate the safety in use of vitamin D and to provide, if necessary, revised Tolerable Upper Intake Levels (ULs) of vitamin D for all relevant population groups. The ULs...

Analytical Method Details (MS): SE29_MS1 [Metabolonote[Archive

Lifescience Database Archive (English)

Full Text Available SE29_MS1 LC-FT-ICR-MS ESI positive method 1 Agilent1100 HPLC (Agilent), LTQ-FT (The... (100mg) are solved in 300uL 80% methanol solution. 20uL sample is injected into HPLC after 0.2um membrane filter treatment. HPLC

Direct quantification of human cytomegalovirus immediate-early and late mRNA levels in blood of lung transplant recipients by competitive nucleic acid sequence-based amplification

NARCIS (Netherlands)

Greijer, AE; Verschuuren, EAM; Harmsen, MC; Dekkers, CAJ; Adriaanse, HMA; The, TH; Middeldorp, JM

The dynamics of active human cytomegalovirus (HCMV) infection was monitored by competitive nucleic acid sequence-based amplification (NASBA) assays for quantification of IE1 (UL123) and pp67 (UL65) mRNA expression levels In the blood of patients after lung transplantation. RNA was isolated from 339

An old man with a mass in the retropharyngeal space

Directory of Open Access Journals (Sweden)

Mohammad Hashemi-Shahri

2009-05-01

Full Text Available <ul>

3D Modelling of Urban Terrain (Modelisation 3D de milieu urbain)

Science.gov (United States)

2011-09-01

Biblioteka Wojskowa 1000 Ljubljana NASA Center for AeroSpace Information (CASI) ul. Ostrobramska 109 7115 Standard Drive 04-041 Warszawa TURQUIE Hanover...29, Avenue de la Division Leclerc ul. Ostrobramska 109 Porton Down BP 72, 92322 Châtillon Cedex 04-041 Warszawa Salisbury SP4 0JQ GERMANY

Enhanced Aircraft Platform Availability Through Advanced Maintenance Concepts and Technologies (Amelioration de la disponibilite des plateformes d’aeronefs au moyen de concepts de maintenance et de technologies evolues)

Science.gov (United States)

2011-06-01

Centralna Biblioteka Wojskowa 1000 Ljubljana NASA Center for AeroSpace Information (CASI) ul. Ostrobramska 109 7115 Standard Drive 04-041 Warszawa ...Building 247 29, Avenue de la Division Leclerc ul. Ostrobramska 109 Porton Down BP 72, 92322 Châtillon Cedex 04-041 Warszawa Salisbury SP4 0JQ

Extracellular matrix collagen alters cell proliferation and cell cycle progression of human uterine leiomyoma smooth muscle cells.

Science.gov (United States)

Koohestani, Faezeh; Braundmeier, Andrea G; Mahdian, Arash; Seo, Jane; Bi, JiaJia; Nowak, Romana A

2013-01-01

Uterine leiomyomas (ULs) are benign tumors occurring in the majority of reproductive aged women. Despite the high prevalence of these tumors, little is known about their etiology. A hallmark of ULs is the excessive deposition of extracellular matrix (ECM), primarily collagens. Collagens are known to modulate cell behavior and function singularly or through interactions with integrins and growth factor-mediated mitogenic pathways. To better understand the pathogenesis of ULs and the role of ECM collagens in their growth, we investigated the interaction of leiomyoma smooth muscle cells (LSMCs) with two different forms of collagen, non-polymerized collagen (monomeric) and polymerized collagen (fibrillar), in the absence or presence of platelet-derived growth factor (PDGF), an abundant growth factor in ULs. Primary cultures of human LSMCS from symptomatic patients were grown on these two different collagen matrices and their morphology, cytoskeletal organization, cellular proliferation, and signaling pathways were evaluated. Our results showed that LSMCs had distinct morphologies on the different collagen matrices and their basal as well as PDGF-stimulated proliferation varied on these matrices. These differences in proliferation were accompanied by changes in cell cycle progression and p21, an inhibitory cell cycle protein. In addition we found alterations in the phosphorylation of focal adhesion kinase, cytoskeletal reorganization, and activation of the mitogen activated protein kinase (MAPK) signaling pathway. In conclusion, our results demonstrate a direct effect of ECM on the proliferation of LSMCs through interplay between the collagen matrix and the PDGF-stimulated MAPK pathway. In addition, these findings will pave the way for identifying novel therapeutic approaches for ULs that target ECM proteins and their signaling pathways in ULs.

Effect of low-intensity pulsed ultrasound on bone regeneration: biochemical and radiologic analyses.

Science.gov (United States)

Pomini, Karina T; Andreo, Jesus C; Rodrigues, Antonio de C; de O Gonçalves, Jéssica B; Daré, Letícia R; German, Iris J S; Rosa, Geraldo M; Buchaim, Rogerio L

2014-04-01

The purpose of this study was to evaluate the effects of low-intensity pulsed ultrasound at 1.0 MHz on the healing process of fractures with bone loss in the rat fibula by alkaline phosphate level measurement and radiologic analyses. Thirty 70-day-old male Wistar rats underwent a bone resection of 2.5 to 3.0 mm between the proximal and middle third of the right fibular diaphysis. The animals were randomly divided into 3 experimental groups: reference (uninjured), control (injured only), and treated (injured and treated with 5 applications of ultrasound, interspersed by 2 days of rest, beginning 24 hours after the osteotomy). Euthanasia was performed at experimental periods of 7 and 14 days. The right hind limb was removed for radiologic analysis. The blood was collected via cardiac puncture to determine the serum alkaline phosphatase activity. The bone fractures had not been completely consolidated in the treated and control group when analysis of the bone took place. At day 7, the serum alkaline phosphatase activity was higher in the treated group (mean ± SD, 72.17 ± 7.02 U/L) compared to the control (65.26 ± 8.41 U/L) and reference (67.21 ± 7.86 U/L) groups. At day 14, higher alkaline phosphatase activity was seen in the control group (68.96 ± 8.12 U/L) compared to the treated (66.09 ± 8.46 U/L) and reference (67.14 ± 7.96 U/L) groups. The biochemical and radiologic results suggest that low-intensity pulsed ultrasound can be used as an auxiliary method to consolidate fractures and probably reduces the bone healing time, offering clinical benefits.

Developing a System for Fish Fauna Migration Restoration Above the Spillway Sill Near the City Hall of Oradea (Romania

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Voicu Răzvan

2015-12-01

Full Text Available The channel of the river Crișul Repede inside the town affects both the biodiversity and implicit functionality of Crișul Repede River, therefore, this article aims to provide a solution for fish fauna migration in a system designed to restore longitudinal connectivity. The proposed migration system is based on the gravitational fall of water and will lead to the restoration of the longitudinal connection of Crişul Repede River near the weir selected as the study case. It will reconnect approximately three kilometers of habitat that will contribute to ensuring the optimal conditions for the development of migratory fish species present in the area.

Jihadhybriden: Fra hellig oprørskamp til toneangivende al-Qaeda-filial

DEFF Research Database (Denmark)

Vestenskov, David

2015-01-01

I Jihadhybriden: Fra hellig oprørskamp til toneangivende al-Qaeda- filial sporres oprindelsen tilbage til den sovjetiske intervention i Afghanistan og udviklingen mellem direkte -og indirekte jihad personificeret ved henholdsvis ISIS’s idegrundlægger Abu Musab al-Zarqawi og den tidligere al-Qaeda......-Qaeda-leder Osama Bin Laden. Kapitlet beskriver, hvorledes den nuværende bevægelse og organisation har udviklet sig til en såkaldt jihadhybrid på baggrund af dels den mujahedinske frihedskamp i 1980ernes Afghanistan, dels al-Qaedas internationale og antivestlige strategi....

AcEST: DK962942 [AcEST

Lifescience Database Archive (English)

Full Text Available Swiss-Prot sp_hit_id P09287 Definition sp|P09287|UL25_VZVD Virion gene 34 protein OS=Varicella-zoster virus (strain Dumas...in 47 O... 30 8.7 >sp|P09287|UL25_VZVD Virion gene 34 protein OS=Varicella-zoster virus (strain Dumas) GN=34

Bench Press Upper-Body Muscle Activation Between Stable and Unstable Loads.

Science.gov (United States)

Dunnick, Dustin D; Brown, Lee E; Coburn, Jared W; Lynn, Scott K; Barillas, Saldiam R

2015-12-01

The bench press is one of the most commonly used upper-body exercises in training and is performed with many different variations, including unstable loads (ULs). Although there is much research on use of an unstable surface, there is little to none on the use of an UL. The purpose of this study was to investigate muscle activation during the bench press while using a stable load (SL) vs. UL. Twenty resistance-trained men (age = 24.1 ± 2 years; ht = 177.5 ± 5.8 cm; mass = 88.7 ± 13.7 kg) completed 2 experimental conditions (SL and UL) at 2 different intensities (60 and 80% one repetition maximum). Unstable load was achieved by hanging 16 kg kettlebells by elastic bands from the end of the bar. All trial lifts were set to a 2-second cadence with a slight pause at the bottom. Subjects had electrodes attached to 5 muscles (pectoralis major, anterior deltoid, medial deltoid, triceps brachii, and latissimus dorsi) and performed 3 isometric bench press trials to normalize electromyographic data. All 5 muscles demonstrated significantly greater activation at 80% compared with 60% load and during concentric compared with eccentric actions. These results suggest that upper body muscle activation is not different in the bench press between UL and SL. Therefore, coaches should use their preference when designing training programs.

The Use of Functional Electrical Stimulation on the Upper Limb and Interscapular Muscles of Patients with Stroke for the Improvement of Reaching Movements: A Feasibility Study

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Alicia Cuesta-Gómez

2017-05-01

Full Text Available IntroductionReaching movements in stroke patients are characterized by decreased amplitudes at the shoulder and elbow joints and greater displacements of the trunk, compared to healthy subjects. The importance of an appropriate and specific contraction of the interscapular and upper limb (UL muscles is crucial to achieving proper reaching movements. Functional electrical stimulation (FES is used to activate the paretic muscles using short-duration electrical pulses.ObjectiveTo evaluate whether the application of FES in the UL and interscapular muscles of stroke patients with motor impairments of the UL modifies patients’ reaching patterns, measured using instrumental movement analysis systems.DesignA cross-sectional study was carried out.SettingThe VICON Motion System® was used to conduct motion analysis.ParticipantsTwenty-one patients with chronic stroke.InterventionThe Compex® electric stimulator was used to provide muscle stimulation during two conditions: a placebo condition and a FES condition.Main outcome measuresWe analyzed the joint kinematics (trunk, shoulder, and elbow from the starting position until the affected hand reached the glass.ResultsParticipants receiving FES carried out the movement with less trunk flexion, while shoulder flexion elbow extension was increased, compared to placebo conditions.ConclusionThe application of FES to the UL and interscapular muscles of stroke patients with motor impairment of the UL has improved reaching movements.

78 FR 38389 - Proposed Modification to the Scopes of Recognition of Several NRTLs

Science.gov (United States)

2013-06-26

... Door Assemblies, Including Positive Pressure Testing of Side-Hinged and Pivoted Swinging Door... 4248-9 Fuseholders--Part 9: Class K. UL 4248-11 Fuseholders--Part 11: Type C (Edison Base) and Type S... 4248-9 Fuseholders--Part 9: Class K. UL 4248-11 Fuseholders--Part 11: Type C (Edison Base) and Type S...

75 FR 44289 - MET Laboratories, Inc.; Application for Expansion of Recognition

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2010-07-28

... connection with this request, NRTL Program staff did not perform an on-site review of MET's recognized sites...-Finishing Machines UL 1230 Amateur Movie Lights UL 1278 Movable and Wall or Ceiling Hung Electric Room... acceptable request for expansion of its recognition as an NRTL. OSHA's review of the application file and...

The relationship between sugar-sweetened beverages and liver enzymes among healthy premenopausal women: a prospective cohort study.

Science.gov (United States)

Shimony, Maya K; Schliep, Karen C; Schisterman, Enrique F; Ahrens, Katherine A; Sjaarda, Lindsey A; Rotman, Yaron; Perkins, Neil J; Pollack, Anna Z; Wactawski-Wende, Jean; Mumford, Sunni L

2016-03-01

To prospectively assess the association between sugar-sweetened beverages (SSB), added sugar, and total fructose and serum concentrations of liver enzymes among healthy, reproductive-age women. A prospective cohort of 259 premenopausal women (average age 27.3 ± 8.2 years; BMI 24.1 ± kg/m(2)) were followed up for up to two menstrual cycles, providing up to eight fasting blood specimens/cycle and four 24-h dietary recalls/cycle. Women with a history of chronic disease were excluded. Alanine and aspartate aminotransferases (ALT and AST, respectively) were measured in serum samples. Linear mixed models estimated associations between average SSB, added sugar, and total fructose intake and log-transformed liver enzymes adjusting for age, race, body mass index, total energy and alcohol intake, and Mediterranean diet score. For every 1 cup/day increase in SSB consumption and 10 g/day increase in added sugar and total fructose, log ALT increased by 0.079 U/L (95 % CI 0.022, 0.137), 0.012 U/L (95 % CI 0.002, 0.022), and 0.031 (0.012, 0.050), respectively, and log AST increased by 0.029 U/L (-0.011, 0.069), 0.007 U/L (0.000, 0.014), and 0.017 U/L (0.004, 0.030), respectively. Women who consumed ≥1.50 cups/day (12 oz can) SSB versus less had 0.127 U/L (95 % CI 0.001, 0.254) higher ALT [percent change 13.5 % (95 % CI 0.1, 28.9)] and 0.102 (95 % CI 0.015, 0.190) higher AST [percent change 10.8 % (95 % CI 1.5, 20.9)]. Sugar-sweetened beverages were associated with higher serum ALT and AST concentrations among healthy premenopausal women, indicating that habitual consumption of even moderate SSB may elicit hepatic lipogenesis.

Effect of Bench Press Load Knowledge on Repetitions, Rating of Perceived Exertion, and Attentional Focus.

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Beaudoin, Christina M; Cox, Zachary; Dundore, Tyler; Thomas, Tayler; Kim, Johnathon; Pillivant, Daniel

2018-02-01

Beaudoin, CM, Cox, Z, Dundore, T, Thomas, T, Kim, J, and Pillivant, D. Effect of bench press load knowledge on repetitions, rating of perceived exertion, and attentional focus. J Strength Cond Res 32(2): 514-519, 2018-Few studies have examined the role of the teleoanticipation during resistance training. The purpose of this study was to examine the effect of bench press (BP) load knowledge on repetitions completed, ratings of perceived exertion (RPEs), and attentional focus (% associative). Thirty-six recreationally active resistance-trained men (n = 25) and women (n = 11) participated in this study (age = 20.97 ± 1.87 years; ht = 174.12 ± 9.41 cm; and mass = 80.14 ± 14.03 kg). All subjects completed 3 testing sessions: (a) 1 repetition maximum (1RM) BP determination; (b) submaximal BP repetitions to fatigue known load (KL); and (c) submaximal BP repetitions to fatigue unknown load (UL). Known load and UL sessions were randomized and counterbalanced and both completed at 70% 1RM. An estimated weight ratio was computed using the subject's estimate of the UL weight relative to the KL weight. An independent samples t-test revealed no significant testing order difference for the estimated weight ratio. Two-way repeated-measures analysis of variances revealed no significant differences in the number of repetitions (p = 0.63), RPE (p = 0.18), or attentional focus (% associative) (p = 0.93) between the KL and UL conditions. Pearson correlations found a moderate positive association between KL repetitions completed and % associative focus when the UL was completed before the KL. Load knowledge did not influence the number of repetitions, RPE, or attentional focus while completing the BP. Further research examining the use of pacing strategies, RPE, and attentional focus during KL and UL conditions are warranted.

Serum Gamma-Glutamyl-Transferase Independently Predicts Outcome After Transarterial Chemoembolization of Hepatocellular Carcinoma: External Validation

Energy Technology Data Exchange (ETDEWEB)

Guiu, Boris, E-mail: boris.guiu@chu-dijon.fr; Deschamps, Frederic [Institut Gustave Roussy, Department of Interventional Radiology (France); Boulin, Mathieu [University Hospital, INSERM U866 (France); Boige, Valerie; Malka, David; Ducreux, Michel [Institut Gustave Roussy, Department of Digestive Oncology (France); Hillon, Patrick [University Hospital, INSERM U866 (France); Baere, Thierry de [Institut Gustave Roussy, Department of Interventional Radiology (France)

2012-10-15

Purpose: An Asian study showed that gamma glutamyl transpeptidase (GGT) can predict survival after transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC). This study was designed to validate in a European population this biomarker as an independent predictor of outcome after TACE of HCC and to determine a threshold value for clinical use. Methods: In 88 consecutive patients treated by TACE for HCC, the optimal threshold for GGT serum level was determined by a ROC analysis. Endpoints were time-to-treatment failure (TTTF) and overall survival (OS). All multivariate models were internally validated using bootstrapping (90 replications). Results: Median follow-up lasted 373 days, and median overall survival was 748 days. The optimal threshold for GGT was 165 U/L (sensitivity: 89.3%; specificity: 56.7%; area under the ROC curve: 0.7515). Median TTTF was shorter when GGT was {>=}165 U/L (281 days vs. 850 days; P < 0.001). GGT {>=}165 U/L (hazard ratio (HR) = 2.06; P = 0.02), WHO PS of 2 (HR = 5.4; P = 0.002), and tumor size (HR = 1.12; P = 0.014) were independently associated with shorter TTTF. Median OS was shorter when GGT was {>=}165 U/L (508 days vs. not reached; P < 0.001). GGT {>=} 165 U/L (HR = 3.05; P = 0.029), WHO PS of 2 (HR = 12.95; P < 0.001), alfa-fetoprotein (HR = 2.9; P = 0.01), and tumor size (HR = 1.096; P = 0.013) were independently associated with shorter OS. The results were confirmed by bootstrapping. Conclusions: Our results provide in a European population the external validation of GGT as an independent predictor of outcome after TACE of HCC. A serum level of GGT {>=} 165 U/L is independently associated with both shorter TTTF and OS.

Serum Gamma-Glutamyl-Transferase Independently Predicts Outcome After Transarterial Chemoembolization of Hepatocellular Carcinoma: External Validation

International Nuclear Information System (INIS)

Guiu, Boris; Deschamps, Frédéric; Boulin, Mathieu; Boige, Valérie; Malka, David; Ducreux, Michel; Hillon, Patrick; Baère, Thierry de

2012-01-01

Purpose: An Asian study showed that gamma glutamyl transpeptidase (GGT) can predict survival after transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC). This study was designed to validate in a European population this biomarker as an independent predictor of outcome after TACE of HCC and to determine a threshold value for clinical use. Methods: In 88 consecutive patients treated by TACE for HCC, the optimal threshold for GGT serum level was determined by a ROC analysis. Endpoints were time-to-treatment failure (TTTF) and overall survival (OS). All multivariate models were internally validated using bootstrapping (90 replications). Results: Median follow-up lasted 373 days, and median overall survival was 748 days. The optimal threshold for GGT was 165 U/L (sensitivity: 89.3%; specificity: 56.7%; area under the ROC curve: 0.7515). Median TTTF was shorter when GGT was ≥165 U/L (281 days vs. 850 days; P < 0.001). GGT ≥165 U/L (hazard ratio (HR) = 2.06; P = 0.02), WHO PS of 2 (HR = 5.4; P = 0.002), and tumor size (HR = 1.12; P = 0.014) were independently associated with shorter TTTF. Median OS was shorter when GGT was ≥165 U/L (508 days vs. not reached; P < 0.001). GGT ≥ 165 U/L (HR = 3.05; P = 0.029), WHO PS of 2 (HR = 12.95; P < 0.001), alfa-fetoprotein (HR = 2.9; P = 0.01), and tumor size (HR = 1.096; P = 0.013) were independently associated with shorter OS. The results were confirmed by bootstrapping. Conclusions: Our results provide in a European population the external validation of GGT as an independent predictor of outcome after TACE of HCC. A serum level of GGT ≥ 165 U/L is independently associated with both shorter TTTF and OS.

Periodontal disease and spontaneous preterm birth: a case control study

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Eley Barry

2006-07-01

Full Text Available Abstract Background Several studies have suggested an association between periodontal disease and prematurity but this finding has not been consistently observed. Methods Case control study. Cases (n = 50 were women who had delivered after spontaneous preterm labor at Results There was no difference in the proportion of sites with significant attachment loss (≥3 mm: Cases-3.2%, Controls-2.2% p = 0.21. The gingival crevicular fluid concentrations of elastase and gingipain were elevated in cases vs. controls 238.8 uU/ul vs. 159.6 uU/ul p = .007 and 2.70 uU/ul vs. 1.56 uU/ul p = .001. On multivariate analysis, the mean log concentration of elastase, but not of gingipain, remained a significant predictor of preterm labor p = .0.015. Conclusion We found no evidence that clinical periodontal disease is associated with spontaneous preterm birth. Elevated gingival crevicular fluid levels of elastase were associated with preterm birth but further research is needed before this can be assumed to be a causal relationship.

The ITER EC H and CD Upper Launcher: Maintenance concepts

International Nuclear Information System (INIS)

Ronden, D.M.S.; Baar, M. de; Chavan, R.; Elzendoorn, B.S.Q.; Grossetti, G.; Heemskerk, C.J.M.; Koning, J.F.; Landis, J.-D.; Spaeh, P.; Strauss, D.

2013-01-01

Highlights: ► We explain how an overall maintenance strategy defines individual maintenance tasks. ► Concepts are presented for replacement strategies of the in-vessel optical components. ► Vertical placement of the Upper Launcher in the Hot Cell may simplify maintenance. -- Abstract: Maintenance of the ITER EC H and CD Upper Launcher (UL) shall be performed through the use of Remote Handling (RH) in the ITER Hot Cell Facility (HCF). The UL design will have to be fully compliant with ITER RH maintenance requirements and the set of RH tooling and services available in the HCF. This paper describes the development of an overall maintenance strategy for the UL, starting from a listing of all conceivable maintenance operations, including hands-on tasks. Components for which design concepts are discussed in this paper are the Blanket Shield Module (BSM), the steering mirror (M4), the mid optics (M1, M2) and the waveguide (WG) feed-through plate. Aspects related to RH documentation, overall maintenance strategy and design concepts for optimizing the maintainability of the UL are presented

Department of Defense Data Model, Version 1, Fy 1998, Volume 2.

Science.gov (United States)

1998-05-31

OOcs hhO . zzuj UJUJ« 22g LULJJQ DCCCQ- 3=0 OOC OOUJ IE DCS 0.0.0. Ul LI O Ü Ul 0 i- t~ 2 < rr DC fi e> n o cr DC n U. U’l UJ (-i...requires consideration of parameters relating to terrain, atmosphere, modulation techniques, energy levels, spurious and harmonic emissions , and noise...F 0 £0000 £1-1-1-1- 1- 1— rr 0 o£ l-OOOO ui ui t: Q LU LU Ul LU D.O.Z z x x x a. CO COLU O CO CO CO CO "--zz z ZZQ ~ xxz X X X X X hhO l-l-l

The ROSCOE Manual. Volume 2-1. Sample Case.

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1980-03-01

tC _ iui)i.’:r:<RC — ü in M M M M w w u) i a: u O Ott *-OOG<i*»< O CJ p- c j UJ tu UJ IL ^ UJ o: UJ fr- 3Ct a: a u ^ i...Ul U 00 X O X X o i ul X z t- • ui O i U Ul I O UJ ox 54 M«n""w* piM >w« 1 -1 3 J>«r^«9o<H^i^7l/)«^C09O««(MHt3kn4)h-(D9O-«njr󈧑l04)M0

75 FR 21664 - Underwriters Laboratories Inc.; Application for Expansion of Recognition

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2010-04-26

... in Metal-Enclosed Switchgear \\a\\ IEEE C37.20.6 4.76 kV to 38 kV Rated Grounding and Testing Devices Used in Enclosures \\a\\ IEEE C37.23 Metal-Enclosed Bus \\a\\ IEEE C37.41 High-Voltage Fuses, Distribution... Electrical Equipment UL 852 Metallic Sprinkler Pipe for Fire Protection Service UL 962 Household and...

Therapeutic Drug Monitoring of Asparaginase Activity-Method Comparison of MAAT and AHA Test Used in the International AIEOP-BFM ALL 2009 Trial.

Science.gov (United States)

Lanvers-Kaminsky, Claudia; Rüffer, Andrea; Würthwein, Gudrun; Gerss, Joachim; Zucchetti, Massimo; Ballerini, Andrea; Attarbaschi, Andishe; Smisek, Petr; Nath, Christa; Lee, Samiuela; Elitzur, Sara; Zimmermann, Martin; Möricke, Anja; Schrappe, Martin; Rizzari, Carmelo; Boos, Joachim

2018-02-01

In the international AIEOP-BFM ALL 2009 trial, asparaginase (ASE) activity was monitored after each dose of pegylated Escherichia coli ASE (PEG-ASE). Two methods were used: the aspartic acid β-hydroxamate (AHA) test and medac asparaginase activity test (MAAT). As the latter method overestimates PEG-ASE activity because it calibrates using E. coli ASE, method comparison was performed using samples from the AIEOP-BFM ALL 2009 trial. PEG-ASE activities were determined using MAAT and AHA test in 2 sets of samples (first set: 630 samples and second set: 91 samples). Bland-Altman analysis was performed on ratios between MAAT and AHA tests. The mean difference between both methods, limits of agreement, and 95% confidence intervals were calculated and compared for all samples and samples grouped according to the calibration ranges of the MAAT and the AHA test. PEG-ASE activity determined using the MAAT was significantly higher than when determined using the AHA test (P Wilcoxon signed-rank test). Within the calibration range of the MAAT (30-600 U/L), PEG-ASE activities determined using the MAAT were on average 23% higher than PEG-ASE activities determined using the AHA test. This complies with the mean difference reported in the MAAT manual. With PEG-ASE activities >600 U/L, the discrepancies between MAAT and AHA test increased. Above the calibration range of the MAAT (>600 U/L) and the AHA test (>1000 U/L), a mean difference of 42% was determined. Because more than 70% of samples had PEG-ASE activities >600 U/L and required additional sample dilution, an overall mean difference of 37% was calculated for all samples (37% for the first and 34% for the second set). Comparison of the MAAT and AHA test for PEG-ASE activity confirmed a mean difference of 23% between MAAT and AHA test for PEG-ASE activities between 30 and 600 U/L. The discrepancy increased in samples with >600 U/L PEG-ASE activity, which will be especially relevant when evaluating high PEG-ASE activities in

Independent predictive factors for significant liver histological changes in patients with HBeAg-positive high-viral-load chronic HBV infection and a normal alanine aminotransferase level

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LI Qiang

2016-07-01

Full Text Available Objective To investigate the independent predictive factors for significant liver histological changes (SLHCs in patients with HBeAg-positive high-viral-load chronic hepatitis B virus (HBV infection and a normal alanine aminotransferase (ALT level. MethodsA retrospective analysis was performed on the clinical data of 116 previously untreated patients with HBeAg-positive high-viral-load (HBV DNA≥105 copies/ml chronic HBV infection and a normal ALT level (＜50 U/L who were hospitalized in Shanghai Public Health Clinical Center Affiliated to Fudan University from June 2013 to August 2015. The definition of SLHCs was inflammation ≥G2 and/or fibrosis≥S2. The t-test or Mann-Whitney U rank sum test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. Univariate and multivariate regression analyses were used to determine independent predictive factors for SLHCs. ResultsOf all the 116 patients, 47(40.5% had SLHCs. The multivariate analysis showed that age (OR=2.828, P＜0.05, ALT (OR=1.011, P＜0.05, and gamma-glutamyl transpeptidase (GGT (OR=1.089, P＜0.05 were independent predictors for SLHCs in patients with HBeAg-positive high-viral-load chronic HBV infection and a normal ALT level. The patients aged ≤30 years had a significantly lower incidence rate of SLHCs than those aged＞30 years (21.6% vs 49.4%, χ2=6.42, P=0.015, the patients with ALT ≤30 U/L had a significantly lower incidence rate of SLHCs than those with 30 U/L＜ALT≤50 U/L (17.6% vs 50.0%, χ2=19.86, P＜0.001, and the patients with GGT≤40 U/L had a significantly lower incidence rate of SLHCs than those with GGT＞40 U/L (28.8% vs 66.7%, χ2=28.63, P＜0.001. ConclusionIn patients with HBeAg-positive high-viral-load chronic HBV infection and a normal ALT level, those with an age of＞30 years, ALT＞30 U/L, and GGT＞40 U/L tend to develop SLHCs and need liver biopsy.

Hand Passive Mobilization Performed with Robotic Assistance: Acute Effects on Upper Limb Perfusion and Spasticity in Stroke Survivors

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Massimiliano Gobbo

2017-01-01

Full Text Available This single arm pre-post study aimed at evaluating the acute effects induced by a single session of robot-assisted passive hand mobilization on local perfusion and upper limb (UL function in poststroke hemiparetic participants. Twenty-three patients with subacute or chronic stroke received 20 min passive mobilization of the paretic hand with robotic assistance. Near-infrared spectroscopy (NIRS was used to detect changes in forearm tissue perfusion. Muscle tone of the paretic UL was assessed by the Modified Ashworth Scale (MAS. Symptoms concerning UL heaviness, joint stiffness, and pain were evaluated as secondary outcomes by self-reporting. Significant (p=0.014 improvements were found in forearm perfusion when all fingers were mobilized simultaneously. After the intervention, MAS scores decreased globally, being the changes statistically significant for the wrist (from 1.6±1.0 to 1.1±1.0; p=0.001 and fingers (from 1.2±1.1 to 0.7±0.9; p=0.004. Subjects reported decreased UL heaviness and stiffness after treatment, especially for the hand, as well as diminished pain when present. This study supports novel evidence that hand robotic assistance promotes local UL circulation changes, may help in the management of spasticity, and acutely alleviates reported symptoms of heaviness, stiffness, and pain in subjects with poststroke hemiparesis. This opens new scenarios for the implications in everyday clinical practice. Clinical Trial Registration Number is NCT03243123.

Hand Passive Mobilization Performed with Robotic Assistance: Acute Effects on Upper Limb Perfusion and Spasticity in Stroke Survivors.

Science.gov (United States)

Gobbo, Massimiliano; Gaffurini, Paolo; Vacchi, Laura; Lazzarini, Sara; Villafane, Jorge; Orizio, Claudio; Negrini, Stefano; Bissolotti, Luciano

2017-01-01

This single arm pre-post study aimed at evaluating the acute effects induced by a single session of robot-assisted passive hand mobilization on local perfusion and upper limb (UL) function in poststroke hemiparetic participants. Twenty-three patients with subacute or chronic stroke received 20 min passive mobilization of the paretic hand with robotic assistance. Near-infrared spectroscopy (NIRS) was used to detect changes in forearm tissue perfusion. Muscle tone of the paretic UL was assessed by the Modified Ashworth Scale (MAS). Symptoms concerning UL heaviness, joint stiffness, and pain were evaluated as secondary outcomes by self-reporting. Significant ( p = 0.014) improvements were found in forearm perfusion when all fingers were mobilized simultaneously. After the intervention, MAS scores decreased globally, being the changes statistically significant for the wrist (from 1.6 ± 1.0 to 1.1 ± 1.0; p = 0.001) and fingers (from 1.2 ± 1.1 to 0.7 ± 0.9; p = 0.004). Subjects reported decreased UL heaviness and stiffness after treatment, especially for the hand, as well as diminished pain when present. This study supports novel evidence that hand robotic assistance promotes local UL circulation changes, may help in the management of spasticity, and acutely alleviates reported symptoms of heaviness, stiffness, and pain in subjects with poststroke hemiparesis. This opens new scenarios for the implications in everyday clinical practice. Clinical Trial Registration Number is NCT03243123.

N-Acetyl-L-Leucine Accelerates Vestibular Compensation after Unilateral Labyrinthectomy by Action in the Cerebellum and Thalamus

Science.gov (United States)

Xiong, Guoming; Potschka, Heidrun; Jahn, Klaus; Bartenstein, Peter; Brandt, Thomas; Dutia, Mayank; Dieterich, Marianne; Strupp, Michael; la Fougère, Christian; Zwergal, Andreas

2015-01-01

An acute unilateral vestibular lesion leads to a vestibular tone imbalance with nystagmus, head roll tilt and postural imbalance. These deficits gradually decrease over days to weeks due to central vestibular compensation (VC). This study investigated the effects of i.v. N-acetyl-DL-leucine, N-acetyl-L-leucine and N-acetyl-D-leucine on VC using behavioural testing and serial [18F]-Fluoro-desoxyglucose ([18F]-FDG)-μPET in a rat model of unilateral chemical labyrinthectomy (UL). Vestibular behavioural testing included measurements of nystagmus, head roll tilt and postural imbalance as well as sequential whole-brain [18F]-FDG-μPET was done before and on days 1,3,7 and 15 after UL. A significant reduction of postural imbalance scores was identified on day 7 in the N-acetyl-DL-leucine (p metabolism (rCGM) by means of μPET revealed that only N-acetyl-L-leucine but not N-acetyl-D-leucine caused a significant increase of rCGM in the vestibulocerebellum and a decrease in the posterolateral thalamus and subthalamic region on days 3 and 7. A similar pattern was found when comparing the effect of N-acetyl-L-leucine on rCGM in an UL-group and a sham UL-group without vestibular damage. In conclusion, N-acetyl-L-leucine improves compensation of postural symptoms after UL in a dose-dependent and specific manner, most likely by activating the vestibulocerebellum and deactivating the posterolateral thalamus. PMID:25803613