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Sample records for hansen type model

  1. Incidence of contralateral versus ipsilateral neurological signs associated with lateralised Hansen type I disc extrusion

    International Nuclear Information System (INIS)

    Smith, J.D.; Newell, S.M.; Budsberg, S.C.; Bennett, R.A.

    1997-01-01

    Asymmetrical neurological signs were noted in 50 dogs presenting with Hansen type I thoracolumbar disc extrusion. Thoracolumbar myelograms and surgical decompression were performed in all cases. Dogs were divided into two groups (acute and chronic) based on the duration of clinical signs prior to presentation to the University of Georgia. Lateralising extradural cord compressive lesions were noted on all myelograms. In the acute group, 35 per cent of the dogs had asymmetrical neurological signs contralateral to the myelographic and surgical lesion, while in the chronic group only 11 per cent had neurological signs contralateral to the lesion. There was found to be no significant difference in frequency of contralateral asymmetrical clinical signs between the two groups (Fischer's exact test; P = 0.095). The high frequency of contralateral signs documents the importance of thoracolumbar myelography for accurate localisation of the disc material before decompressive surgery

  2. Alfred Hansen

    DEFF Research Database (Denmark)

    Friis, Ib; Wind, Peter; Pedersen, Henrik Ærenlund

    2008-01-01

    Nekrolog over botanikeren Alfred Hansen, leder af Dansk Herbarium på Botanisk Museum, Københavns Universitet, med gennemgang af hans videnskabelige og formidlende publikationer og indsats som samler af videnskabeligt materiale.......Nekrolog over botanikeren Alfred Hansen, leder af Dansk Herbarium på Botanisk Museum, Københavns Universitet, med gennemgang af hans videnskabelige og formidlende publikationer og indsats som samler af videnskabeligt materiale....

  3. Modelo natural de dicotomía TH1-TH2: La enfermedad de Hansen Th1-TH2 balance. Natural model: Hansen'disease

    Directory of Open Access Journals (Sweden)

    N. L Vaquero

    2010-09-01

    Full Text Available La enfermedad de Hansen producida por el Mycobacterium leprae, es una enfermedad infecciosa cuyo amplio espectro clínico e inmunopatológico se correlaciona con los diferentes patrones de respuesta Th1/Th2. La activación preferencial de esas subpoblaciones de linfocitos T CD4 juega un rol importante en su patogenia y constituye un modelo natural de esa dicotomía de la respuesta inmune. Ambas formas polares de la lepra presentan un perfil definido de secreción de citoquinas: Th1 (IL2 e IFN? en el polo tuberculoide y Th2 (IL4, IL5, IL10 en el polo lepromatoso. En el primer caso, la respuesta celular adecuada estimula la activación macrofágica y lleva a la destrucción del bacilo. Las lesiones son escasas y limitadas a la piel y nervios periféricos. En el segundo en cambio, la respuesta celular es casi nula y los bacilos se multiplican descontroladamente dentro de los macrófagos, llevando a la diseminación de las lesiones y afectación de otros órganos. La inmunidad humoral está exacerbada y hay un alto nivel de anticuerpos que no pueden eliminar el germen intracelular. Los factores que determinan la diferenciación hacia una respuesta Th1 ó Th2 no se han esclarecido totalmente. Se han postulado varias hipótesis que hacen referencia a factores genéticos, prevalencia de citoquinas en el microambiente celular, disfunción macrofágica; alteración en los receptores Toll de la inmunidad innata, en la expresión de moléculas coestimulatorias, etc En los últimos años se han descubierto nuevas subpoblaciones de linfocitos, (CD4+ CD25+, Tr1, Th3 y Th17 que estarían implicadas en la desregulación de estas respuestas inmunes.Hansen' disease, caused by Mycobacterium leprae, is an infectious illness whose wide clinical and immunopathologic spectrum correl with different Th1/Th2 responses patterns. The prefferencial activation of the CD4 T cells subset play an important rol in it's pathogenia and provides a natural model of that balance

  4. Leprosy (Hansen's Disease)

    Science.gov (United States)

    ... with facebook share with twitter share with linkedin Leprosy (Hansen's Disease) Credit: NIAID Some classic histopathologic changes ... as Mycobacterium leprae . Why Is the Study of Leprosy (Hansen's Disease) a Priority for NIAID? At the ...

  5. Use of skin graft "punch graft" type for the healing of leg ulcers in treated hansen's disease patients

    OpenAIRE

    Cardia, Carla Christiane de Oliveira

    2006-01-01

    Hansen's disease is an infectious illness caused by Mycobacterium leprae. It affects preferentially the skin and the peripheral nervous system leading to incapacities, such as leg ulcers, which happens due to the direct action of the bacillus on the organs or its indirect action on the peripheral nervous system. Leg ulcers can occur by two physiopathologic processes. There are many treatments for general leg ulcers, which include the ones caused by Hansen's disease sequels. Among them, surgic...

  6. National Hansen's Disease (Leprosy) Program

    Science.gov (United States)

    ... Caring and Curing Since 1894 National Hansen's Disease (Leprosy) Program Caring and Curing Since 1894 A genetic ... Louisiana New York Texas The National Hansen's Disease (Leprosy) Program The National Hansen's Disease Program is the ...

  7. Revisiting Hansen Solubility Parameters by Including Thermodynamics

    NARCIS (Netherlands)

    Louwerse, Manuel J; Fernández-Maldonado, Ana María; Rousseau, Simon; Moreau-Masselon, Chloe; Roux, Bernard; Rothenberg, Gadi

    2017-01-01

    The Hansen solubility parameter approach is revisited by implementing the thermodynamics of dissolution and mixing. Hansen's pragmatic approach has earned its spurs in predicting solvents for polymer solutions, but for molecular solutes improvements are needed. By going into the details of entropy

  8. Hansen Solubility Parameters for Octahedral Oligomeric Silsesquioxanes

    Science.gov (United States)

    2012-08-28

    1997, 80, 386-&. 5. Hansen, C. M. The three-dimensional solubility parameter -- key to paint component affinities I. J. Paint Technol. 1967, 39, 104...Chai, J.; Zhang, Q. X.; Han, D. X.; Niu, L. Synthesis and Application of Widely Soluble Graphene Sheets. Langmuir 2010, 26, 12314-12320. 12. Hansen, C

  9. Gallium scintigraphy in Hansen's disease

    International Nuclear Information System (INIS)

    Braga, F.J.H.N.; Sao Paulo Univ., SP; Araejo, E.B.; Camargo, E.E.; Tedesco-Marchesi, L.C.M.; Rivitti, M.C.M.; Bouladour, H.; Galle, P.

    1991-01-01

    Gallium 67 imaging was used in 12 patients with documented Hansen's disease undergoing treatment or not in an attempt to determine the pattern of the disease. Diagnosis was confirmed by histopathology in all patients. The Mitsuda reaction was seen in all patients. Specific nuclear studies were performed when needed to evaluate particular organs better. Gallium 67 images show homogeneous, diffuse and moderate accumulation over the entire skin surface (except for the face) of untreated patients with multibacillary disease. The face skin in these cases presented homogeneous, diffuse but very marked uptake of gallium. Internal organ involvement was variable. There was a very good correlation among clinical, scintigraphical, immunological and histopathological data. The pattern of the body skin ('skin outlining') and face skin ('beard distribution') may be distinct for untreated patients with multibacillary leprosy. (orig.)

  10. Hansen solubility parameters for a carbon fiber/epoxy composite

    DEFF Research Database (Denmark)

    Launay, Helene; Hansen, Charles M.; Almdal, Kristoffer

    2007-01-01

    In this study, the physical affinity between an epoxy matrix and oxidized, unsized carbon fibers has been evaluated using Hansen solubility (cohesion) parameters (HSP). A strong physical compatibility has been shown, since their respective HSP are close. The use of a glassy carbon substrate...... as a model for unsized carbon fiber has been demonstrated as appropriate for the study of interactions between the materials in composite carbon fiber-epoxy systems. The HSP of glassy carbon are similar to those of carbon fibers and epoxy matrix. (C) 2007 Elsevier Ltd. All rights reserved....

  11. [Immune response of Hansen's disease. Review].

    Science.gov (United States)

    Rada, Elsa; Aranzazu, Nacarid; Convit, Jacinto

    2009-12-01

    Hansen's disease presents a wide spectrum of clinical and histopathological manifestations that reflect the nature of the immunological response of the host towards diverse Mycobacterium leprae components. The immunological system, composed by both innate and adaptive immunology, offers protection towards infections of various etiologies, among them bacterial. Bacteria, of course, have developed multiple strategies for evading host defenses, based on either very complex or simple mechanisms, but with a single purpose: to "resist" host attacks and to be able to survive. We have tried to summarize some recent studies in Hansen's disease, with more emphasis in the inmunology area. We think that in the future, all illnesses should also be very strongly related to other important aspects such as the social, environmental and economic, and whose development is not solved in a laboratory.

  12. Peter Andreas Hansen und die astronomische Gemeinschaft - eine erste Auswertung des Hansen-Nachlasses.

    Science.gov (United States)

    Schwarz, O.; Strumpf, M.

    The literary assets of Peter Andreas Hansen are deposited in the Staatsarchiv Hamburg, the Forschungs- und Landesbibliothek Gotha and the Thüringer Staatsarchiv Gotha. They were never systematically investigated. The authors present here some results of a first evaluation. It was possible to reconstruct the historical events with regard to the maintenance of the Astronomische Nachrichten and the Altona observatory in 1854. Hansen was a successful teacher for many young astronomers. His way of stimulating the evolution of astronomy followed Zach's tradition.

  13. Type I supernova models

    International Nuclear Information System (INIS)

    Canal, Ramon; Labay, Javier; Isern, Jordi

    1987-01-01

    We briefly describe the characteristics of Type I supernova outbursts and we present the theoretical models so far advanced to explain them. We especially insist on models based on the thermonuclear explosion of a white dwarf in a close binary system, even regarding the recent division of Type I supernovae into the Ia and Ib subtypes. Together with models assuming explosive thermonuclear burning in a fluid interior, we consider in some detail those based on partially solid interiors. We finally discuss models that incorporate nonthermonuclear energy contributions, suggested in order to explain Type Ib outbursts. (Author)

  14. Características da reação tipo 1 e associação com vírus B e C da hepatite na hanseníase Type 1 reaction in leprosy: characteristics and association with hepatitis B and C viruses

    Directory of Open Access Journals (Sweden)

    Vitória P.A. Rego

    2007-10-01

    Full Text Available O episódio reacional tipo 1 ou reação reversa é ocorrência inflamatória aguda que atinge a pele e nervos periféricos, encontrada em até 30% dos pacientes com hanseníase, sendo causa comum de incapacidade física. Fatores de risco associados incluem uso de poliquimioterapia e infecções virais. Neste estudo, foram avaliados 620 pacientes com hanseníase. Reação reversa foi diagnosticada em 121 (19,5% casos, sendo mais freqüente nos indivíduos borderlines (48%. Início da poliquimioterapia foi considerado fator de risco para reação reversa, com 52% dos casos apresentando o primeiro episódio neste momento. Neurite foi documentada em 73% dos casos. A presença de vírus B ou C da hepatite foi documentada em 9% de 55 pacientes com reação reversa e em nenhum dos 57 pacientes sem reação (p = 0, 026; teste exato de Fisher, sugerindo possível papel destes agentes como fatores de risco para desenvolvimento de reação reversa na hanseníase.Type 1 reaction or reversal reaction is an acute inflammatory episode in the skin and peripheral nerves that is found in up to 30% of leprosy patients and commonly causes physical disabilities. Multidrug chemotherapy and viral infections are associated risk factors. In this study, 620 leprosy patients were evaluated. Reversal reactions were diagnosed in 121 cases (19.5% and were most frequently found in borderline patients (48%. Starting on multidrug chemotherapy was considered to be a risk factor for reversal reaction: 52% of the cases presented their first episode at this time. Neuritis was found in 73% of the cases. The presence of hepatitis B or C virus was documented in 9% of the 55 patients with reversal reaction, while it was not detected in any of the 57 patients without reaction (p = 0.026, Fisher’s exact test. This suggests that these agents may have a role as risk factors for developing reversal reactions.

  15. Type 2 diabetes models

    DEFF Research Database (Denmark)

    Gram, Dorte Xenia

    2012-01-01

    This chapter deals with type 2 diabetes in vivo models and techniques suitable for testing new anti-diabetic compounds. In particular, the testing of TRP antagonist for beneficial effects against type 2 diabetes is considered. There are many choices of both in vitro techniques and in vivo models......, impaired glucose tolerance, impaired insulin secretion, and insulin resistance in vivo and should, thus, be sufficient to demonstrate preclinical proof of concept of a TRP antagonist in type 2 diabetes in rodents. The experiments are suggestions and could be replaced or supplemented by others....

  16. Closed loop identification using a modified Hansen scheme

    DEFF Research Database (Denmark)

    Sekunda, André Krabdrup; Niemann, Hans Henrik; Poulsen, Niels Kjølstad

    2015-01-01

    in closed loop [4], and one such method is the Hansen scheme [1]. Standard identification using Hansen scheme demands generating the identification signals indirectly. In this paper it is instead proposed to use the relationship between the Youla factorization of a plant and its stabilizing controller...... in order to keep the system stable. Furthermore because the dynamics of such a system depends on the rotational speed it is needed to conduct an identification while the system is part of a closed loop scheme. The authors believe the paper able to contribute towards a simpler and more direct way...... of identifying closed loop plants using Hansen scheme....

  17. Genética e hanseníase

    Directory of Open Access Journals (Sweden)

    Bernardo Beiguelman

    Full Text Available As diferentes linhas de pesquisa utilizadas para investigar a importância dos fatores hereditários humanos na determinação da resistência/suscetibilidade à infecção pelo Mycobacterium leprae foram discutidas no presente trabalho. Uma síntese dessas abordagens permitiu analisar os resultados das investigações sobre associação da hanseníase com polimorfismos genéticos, distribuição familial da hanseníase, prevalência da hanseníase e distância genética, concordância da hanseníase em gêmeos e estudos genéticos sobre a reação de Mitsuda.

  18. Genética e hanseníase

    OpenAIRE

    Beiguelman Bernardo

    2002-01-01

    As diferentes linhas de pesquisa utilizadas para investigar a importância dos fatores hereditários humanos na determinação da resistência/suscetibilidade à infecção pelo Mycobacterium leprae foram discutidas no presente trabalho. Uma síntese dessas abordagens permitiu analisar os resultados das investigações sobre associação da hanseníase com polimorfismos genéticos, distribuição familial da hanseníase, prevalência da hanseníase e distância genética, concordância da hanseníase em gêmeos e est...

  19. Peter Andreas Hansen and the astronomical community - a first investigation of the Hansen papers. (German Title: Peter Andreas Hansen und die astronomische Gemeinschaft - eine erste Auswertung des Hansen-Nachlasses. )

    Science.gov (United States)

    Schwarz, Oliver; Strumpf, Manfred

    The literary assets of Peter Andreas Hansen are deposited in the Staatsarchiv Hamburg, the Forschungs- und Landesbibliothek Gotha and the Thüringer Staatsarchiv Gotha. They were never systematically investigated. We present here some results of a first evaluation. It was possible to reconstruct the historical events with regard to the maintenance of the Astronomische Nachrichten and the Altona observatory in 1854. Hansen was a successful teacher for many young astronomers. His way of stimulating the evolution of astronomy followed Zach's tradition.

  20. Fatal Klebsiella pneumoniae meningitis in a patient with diabetes mellitus and Hansen's disease.

    Science.gov (United States)

    Gopal, Vani; Mangaiyarkarasi, T; Gopal, R

    2014-01-01

    Klebsiella is a Gram-negative bacterium that causes different types of health care-associated infections including pneumonia, bloodstream infections, surgical site infections and meningitis. We report here a case of Klebsiella pneumoniae meningitis in a patient with diabetes mellitus and Hansen's disease. A middle-aged man with a known case of diabetes mellitus and Hansen's disease presented with the complaints of blurred vision in the left eye and the patient was found to have cataract. Patient was operated for cataract and Intraocular lens implanted. Patient developed headache and vomiting on the 4th post-operative day. Lumbar puncture was carried out and gram stain of cerebrospinal fluid showed Gram-negative bacilli in the direct smear and culture yielded a heavy growth of K. pneumoniae. The patient was treated with antimicrobials according to the susceptibility pattern. He initially showed improvement but later on developed altered sensorium and hypotension. Patient succumbed to infection in spite of all medical attention.

  1. The divergence of Hansen-Sengupta method applied on Trapezoidal

    African Journals Online (AJOL)

    The Hansen-Sengupta operator is discussed in the light of circular interval arithmetic for the algebraic inclusion of zeros of nonlinear interval systems of equations which is known to be efficient for handling such problems. It was the aim of this paper to extend such good convergence behavior possessed by ...

  2. A hanseníase no laboratório Hansen's disease in the laboratory

    Directory of Open Access Journals (Sweden)

    Euzenir Nunes Sarno

    2003-01-01

    Full Text Available Médica, doutora em patologia, Euzenir Sarno é estudiosa da imunopatologia da hanseníase, infecção crônica das mais antigas que constitui uma doença exclusivamente humana. Integrante de um dos ambulatórios de referência sobre a doença no Brasil, no qual são diagnosticados de 220 a 250 pacientes novos/ano, ressalta que uma das conseqüências da impossibilidade de se cultivar o Mycobacterium leprae é a permanência das mesmas questões seculares a respeito da transmissão e a suscetibilidade à doença. Há, também, muitas interrogações no terreno epidemiológico que permanecem sem resposta. Estima-se que entre as pessoas que mantêm contato com pacientes multibacilares, 90% são infectados mas apenas 8% mais ou menos ficam doentes. O índice elevado de infecção de quem convive com doentes multibacilares, sem que a doença se manifeste, indica que apenas um pequeno número de indivíduos não tem resistência ao Mycobacterium leprae. Essa é uma das questões que a imunologia não consegue responder: por que algumas pessoas têm resistência e outras não. A proporção é menor se o contato ocorrer com pacientes paucibacilares, uma forma de manifestação com poucos bacilos. A hanseníase é conhecida como uma doença dermatológica, mas a especialista destaca que a primeira lesão é anestésica: o nervo é atingido. Além dos nervos sensitivos da pele, há danos que determinam lesões motoras e deformidades irreversíveis, que levam à amputação de extremidades. O Mycobacterium leprae foi uma das primeiras bactérias patogênicas que tiveram o genoma completamente seqüenciado, em 2000. Agora é que se está começando a ter realmente condições para obter testes mais precisos. A doença não é hereditária e apenas em 1986 os serviços de saúde no Brasil passaram a se organizar para combatê-la, pois durante os vinte anos de ditadura militar o sistema foi desmantelado. Em 1991, o tratamento de um ano que inclui tr

  3. Imunologia da hanseníase Immunology of leprosy

    Directory of Open Access Journals (Sweden)

    Vanessa Amaral Mendonça

    2008-08-01

    Full Text Available A hanseníase é doença crônica infecciosa que se caracteriza por apresentar formas clínicas contrastantes, que são dependentes da interação do bacilo com a resposta imune do hospedeiro. O estudo dos processos imunológicos torna-se fundamental para o entendimento dos mecanismos envolvidos na apresentação e no desenvolvimento da doença. Neste artigo, é revisada a imunopatogênese da hanseníase.Leprosy is a chronic infectious disease characterized by contrasting clinical forms that are dependent on the interactions between the bacillus and the host immune response. Thus, the study of the immunological process is extremely relevant for the comprehension of the mechanisms involved in leprosy presentation and development. In this paper, the immunopathogenesis of leprosy is reviewed.

  4. Podometry: a critical evaluation of its use in Hansen's disease

    Directory of Open Access Journals (Sweden)

    Júlia Maria D'Andréa Greve

    Full Text Available The aim of this paper is to evaluate the effectiveness of podometry to measure the pressure developed over the feet and the value of these findings to help in the prevention of the plantar neuropathic ulcer in patients bearing Hansen's disease. We evaluated 13 patients with impaired plantar pain and touch sensations and 17 normal patients. All the patients were submitted to static evaluation using the podometer. The system employed was the "Midcapteur" commercial podometer composed of a platform for acquisition of analogic data capable of registering the segmental pressures applied to the feet. These data are read by a 386 IBM/PC compatible computer that registers the graphic patterns obtained from the pressures developed and also calculates the modes of pressure distribution in the four quadrants of the foot. These data obtained by means of static podometry were compared to the clinical evaluation of pain and touch sensation of the feet in hansenian patients. The results demonstrate that podometery is an efficient method for evaluating the pressure in impaired feet in Hansen's disease and is a progression of neuropathic ulcer; it is sensitive in the identification of the spots of increased pressure in anesthetic and anomalous areas, asymmetries and in correlating the presence of ulcers with increased pressure.

  5. The Value of Social Constructionism for the Counseling Profession: A Reply to Hansen

    Science.gov (United States)

    Rudes, James; Guterman, Jeffrey T.

    2007-01-01

    The authors reply to J. T. Hansen's (2005) call for the profession to revalue the inner subjective experiences (ISE) of clients. Hansen argued that social constructionism has influenced the decline of the counseling profession by obscuring its unique focus on ISE. The authors maintain that social constructionism is a useful framework for…

  6. A Return to the Human in Humanism: A Response to Hansen's Humanistic Vision

    Science.gov (United States)

    Lemberger, Matthew E.

    2012-01-01

    In his extension of the humanistic vision, Hansen (2012) recommends that counseling practitioners and scholars adopt operations that are consistent with his definition of a multiple-perspective philosophy. Alternatively, the author of this article believes that Hansen has reduced the capacity of the human to interpret meaning through quantitative…

  7. Type IV Wind Turbine Model

    DEFF Research Database (Denmark)

    Hansen, Anca Daniela; Margaris, Ioannis D.

    . In the project, this wind turbine model will be further incorporated in a wind power plant model together with the implementation in the wind power control level of the new control functionalities (inertial response, synchronising power and power system damping). For this purpose an aggregate wind power plant......This document is created as part of the EaseWind project. The goal of this project is to develop and investigate new control features for primary response provided by wind power plants. New control features as inertial response, synchronising power and power system damping are of interest to EaseWind...... project to be incorporated in the wind power plant level. This document describes the Type 4 wind turbine simulation model, implemented in the EaseWind project. The implemented wind turbine model is one of the initial necessary steps toward integrating new control services in the wind power plant level...

  8. Panorama sobre a hanseníase: quadro atual e perspectivas A panorama of Hansen's disease: present status and perspectives

    Directory of Open Access Journals (Sweden)

    Tadiana Alves Moreira

    2003-01-01

    Full Text Available A entrevistada fala sobre a endemia no Brasil, atualmente com 4.4 casos por dez mil habitantes, sendo o segundo país em número de doentes. Ao discorrer sobre o engajamento do Brasil no programa lançado pela Organização Mundial de Saúde, Tadiana explica que o objetivo da OMS é eliminar a hanseníase até 2005. No entanto, ela diz que a meta brasileira é, neste prazo, reduzir a incidência da doença a até menos de um caso por dez mil pessoas. Em nosso país, a estrutura e organização de tal programa, que engloba desde a formação e especialização de profissionais para garantir o diagnóstico precoce, ao acompanhamento do paciente durante o tratamento, é realizado pelo Sistema Único de Saúde (SUS, implantado em todos os estados da federação. O tratamento poliquimioterápico dura, em média, um ano, se for seguido à risca. Em muitos casos, a doença volta a se manifestar posteriormente. Ela comenta as diferenças de incidência da hanseníase, dependendo da região: já foi eliminada em dois dos três estados do Sul do país, ao passo que em estados do Norte e Centro-Oeste atinge índices hiperendêmicos. Trabalhando em estreita articulação com as associações de pacientes e ex-pacientes, inicialmente como enfermeira e, depois, na implantação das políticas de atenção ao hanseniano, Tadiana Alves Moreira fala sobre a importância do diagnóstico precoce visando evitar seqüelas físicas que a doença provoca quando alcança estágios avançados, e assim, reduzir o estigma que recai sobre os seus portadores.The interviewee speaks about the endemic disease, which at present contaminates 4.4 out of ten thousand inhabitants in Brazil, the country with the second highest number of patients. When Tadiana speaks about the Brazilian participation in the program launched by the World Health Organization, she explains that WHO's objective is to extinguish Hansen's disease on the planet until 2005. However, she says that Brazilian

  9. Techniques used in the exploration of turbidite reservoirs in a frontier setting - Helland Hansen setting, Voering Basin, offshore Mid Norway

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez-Ferrer, F.; James, S.D.; Lak, B.; Evans, A.M.

    1998-12-31

    In the 15th Norwegian licensing round there was awarded operation of the Helland Hansen deep water license. Subsurface interpretation commenced towards the end of 1996, following completion of a 1540 km{sup 2} 3-D seismic survey. The main exploration target comprise Turonian to Coniacian turbidite sands within a large fault-bound dip closure. This presentation describes various techniques applied in the exploration of this new turbidite play, with emphasis on the study of the reservoir potential. A methodology of integrated analysis is presented. Through these efforts, a greater understanding of the lithological and depositional models in this non-calibrated area has progressively been achieved. 5 refs., 11 figs.

  10. Truth and opinion in climate change discourse: the Gore-Hansen disagreement.

    Science.gov (United States)

    Russill, Chris

    2011-11-01

    In this paper, I discuss the "inconvenient truth" strategy of Al Gore. I argue that Gore's notion of truth upholds a conception of science and policy that narrows our understanding of climate change discourse. In one notable exchange, Gore and NASA scientist, James Hansen, disagreed about whether scientific statements based on Hansen's computer simulations were truth or opinion. This exchange is featured in An Inconvenient Truth, yet the disagreement is edited from the film and presented simply as an instance of Hansen speaking "inconvenient truth". In this article, I compare the filmic representation of Hansen's testimony with the congressional record. I place their exchange in a broader historical perspective on climate change disputation in order to discuss the implications of Gore's perspective on truth.

  11. Active Surveillance of Hansen's Disease (Leprosy): Importance for Case Finding among Extra-domiciliary Contacts

    Science.gov (United States)

    Moura, Maria L. N.; Dupnik, Kathryn M.; Sampaio, Gabriel A. A.; Nóbrega, Priscilla F. C.; Jeronimo, Ana K.; do Nascimento-Filho, Jose M.; Miranda Dantas, Roberta L.; Queiroz, Jose W.; Barbosa, James D.; Dias, Gutemberg; Jeronimo, Selma M. B.; Souza, Marcia C. F.; Nobre, Maurício L.

    2013-01-01

    Hansen's disease (leprosy) remains an important health problem in Brazil, where 34,894 new cases were diagnosed in 2010, corresponding to 15.3% of the world's new cases detected in that year. The purpose of this study was to use home visits as a tool for surveillance of Hansen's disease in a hyperendemic area in Brazil. A total of 258 residences were visited with 719 individuals examined. Of these, 82 individuals had had a previous history of Hansen's disease, 209 were their household contacts and 428 lived in neighboring residences. Fifteen new Hansen's disease cases were confirmed, yielding a detection rate of 2.0% of people examined. There was no difference in the detection rate between household and neighbor contacts (p = 0.615). The two groups had the same background in relation to education (p = 0.510), household income (p = 0.582), and the number of people living in the residence (p = 0.188). Spatial analysis showed clustering of newly diagnosed cases and association with residential coordinates of previously diagnosed multibacillary cases. Active case finding is an important tool for Hansen's disease control in hyperendemic areas, enabling earlier diagnosis, treatment, decrease in disability from Hansen's disease and potentially less spread of Mycobacterium leprae. PMID:23516645

  12. REACTIONAL STATES IN MULTIBACILLARY HANSEN DISEASE PATIENTS DURING MULTIDRUG THERAPY

    Directory of Open Access Journals (Sweden)

    José A.C. NERY

    1998-11-01

    Full Text Available It is well known that reactions are commonplace occurrences during the course of leprosy disease. Stigmatization may even be attributable to reactions which are also responsible for the worsening of neural lesions. A cohort of 162 newly-diagnosed baciloscopically positive patients from the Leprosy Care Outpatient Clinic of the Oswaldo Cruz Foundation (FIOCRUZ was selected for this study. While 46% of the multibacillary (MB patients submitted to the 24 fixed-dose multidrug therapy (MDT regimen suffered reactions during treatment, it was found that all MBs were susceptible and that constant attention and care were required at all times. Fourteen per cent were classified as BB, 52% as BL, and 33% as LL. None of the variables under study, such as, sex, age, clinical form, length of illness, length of dermatological lesions, baciloscopic index (BI, or degree of disability proved to be associate with reaction among the patients studied. Reversal Reaction (RR occurred in 45%, and Erythema Nodosum Leprosum (ENL occurred in 55%. Among BB patients who developed reactions (15 patients, 93% presented RR; while among the LL patients who developed reactions (34 patients, 91% presented ENL. Likewise, ENL was very frequent among those with disseminate lesions, while RR was most often observed in patients with segmentary lesions. RR was also most likely to occur during the initial months of treatment. It was demonstrated that the recurrence rate of ENL was significantly higher than that of RR. Neither grade of disability nor BI was shown to be associated with RR and ENL reaction. However, the RR rate was significantly higher among patients showing BI 3.Reações são ocorrências comuns no curso da hanseníase e são responsáveis pelo agravamento das lesões neurais. Uma coorte de 162 pacientes recém-diagnosticados, baciloscopicamente positivos, em acompanhamento no Ambulatório de Hanseníase da Fundação Oswaldo Cruz (FIOCRUZ foi selecionada para estudo

  13. Type-2 fuzzy granular models

    CERN Document Server

    Sanchez, Mauricio A; Castro, Juan R

    2017-01-01

    In this book, a series of granular algorithms are proposed. A nature inspired granular algorithm based on Newtonian gravitational forces is proposed. A series of methods for the formation of higher-type information granules represented by Interval Type-2 Fuzzy Sets are also shown, via multiple approaches, such as Coefficient of Variation, principle of justifiable granularity, uncertainty-based information concept, and numerical evidence based. And a fuzzy granular application comparison is given as to demonstrate the differences in how uncertainty affects the performance of fuzzy information granules.

  14. [Outcome of operative treatment for supination-external rotation Lauge-Hansen stage IV ankle fractures].

    Science.gov (United States)

    Kołodziej, Łukasz; Boczar, Tomasz; Bohatyrewicz, Andrzej; Zietek, Paweł

    2010-01-01

    Ankle fractures are among the most common musculoskeletal injures. These fractures occur with an overall age- and sex-adjusted incidence rate around 180 per 100 000 person-years. The most frequent mechanism is considered to be supination-external rotation (60 to 80% of all ankle fractures) consisting of pathologic external rotation of the foot initially placed in some degree of supination. According to Lauge-Hansen classification, ankle joint structures are damaged in a sequence where the final, stage IV injuries, represents transverse fracture of the medial malleolus or its equivalent-rupture of the deltoid ligament. The aim of this study is to compare the results of two subtypes of supination-external rotation stage IV fractures. 43 patients treated surgically in 2006 to 2007 at Authors institution because of stage IV supination-external rotation ankle fracture were submitted to retrospective analysis. There were 25 patients with bimalleolar fracture (type 1) and in 18 patients with lateral malleolar fracture with accompanying rupture of the deltoid ligament (type 2). The mean age was 46 years (from 20 to 82 years). Average follow up period was 37 months (from 24 to 46 months). For the evaluation of treatment AOFAS hind-foot score (American Orthopedic Foot and Ankle Society) was used. The mean AOFAS score scale for Type 1 fractures was 85 points and for type 2 was significantly higher and amounted to 91 points (p ankle fractures with medial malleolar fracture, requires the implementation of additional diagnostic and therapeutic strategies and procedures in order to improve the outcome of results.

  15. Instream Physical Habitat Modelling Types

    DEFF Research Database (Denmark)

    Conallin, John; Boegh, Eva; Krogsgaard, Jørgen

    2010-01-01

    The introduction of the EU Water Framework Directive (WFD) is providing member state water resource managers with significant challenges in relation to meeting the deadline for 'Good Ecological Status' by 2015. Overall, instream physical habitat modelling approaches have advantages and disadvanta......The introduction of the EU Water Framework Directive (WFD) is providing member state water resource managers with significant challenges in relation to meeting the deadline for 'Good Ecological Status' by 2015. Overall, instream physical habitat modelling approaches have advantages...... suit their situations. This paper analyses the potential of different methods available for water managers to assess hydrological and geomorphological impacts on the habitats of stream biota, as requested by the WFD. The review considers both conventional and new advanced research-based instream...... physical habitat models. In parametric and non-parametric regression models, model assumptions are often not satisfied and the models are difficult to transfer to other regions. Research-based methods such as the artificial neural networks and individual-based modelling have promising potential as water...

  16. Hansen Re-Visited: Alternative Methodology for Istanbul Land Use Pattern

    Directory of Open Access Journals (Sweden)

    Kerem Yavuz Arslanlı

    2016-12-01

    Full Text Available In this paper, Hansen model applied to Istanbul districts and increasing the distribution of the population of 3 million were calculated. Istanbul, population and income growth, the service sector, based in the city's development as a result of advances in transportation and telecommunications, the restructuring of the city, and this encourages residential, commercial and office create opportunities for investments. Land-use decision-making process is a very complex includes site selection. Estimates of population growth, starting from the development potential on the one hand, depending on the location of the settlements, and the physical, socio-economic, legal and political characteristics of the functional needs of the city overlaps with each other to create the most effective form is required. In addition, the sub-centers produced a gradual effect of the interaction and the environment as a result of a lot of alternatives for the purpose of evaluating the size of the new centers and, instead, may be decided taking into account the dimension of time. Thus, the development of the whole city and the economic development of the system to provide the most effective when planned. By investing just as it is today, at certain points, and the creation of high-quality urban services bringing the speculation, raising the quality of life of city-wide, but can provide a healthy socio-economic development.

  17. Validity of Hansen-Roach cross sections in low-enriched uranium systems

    International Nuclear Information System (INIS)

    Busch, R.D.; O'Dell, R.D.

    1991-01-01

    Within the nuclear criticality safety community, the Hansen-Roach 16 group cross section set has been the ''standard'' for use in k eff calculations over the past 30 years. Yet even with its widespread acceptance, there are still questions about its validity and adequacy, about the proper procedure for calculating the potential scattering cross section, σ p , for uranium and plutonium, and about the concept of resonance self shielding and its impact on cross sections. This paper attempts to address these questions. It provides a brief background on the Hansen-Roach cross sections. Next is presented a review of resonances in cross sections, self shielding of these resonances, and the use of σ p to characterize resonance self shielding. Three prescriptions for calculating σ p are given. Finally, results of several calculations of k eff on low-enriched uranium systems are provided to confirm the validity of the Hansen-Roach cross sections when applied to such systems

  18. Social representation of Hansen's disease thirty years after the term 'leprosy' was replaced in Brazil

    Directory of Open Access Journals (Sweden)

    Oliveira Maria Leide Wand-del-Rey de

    2003-01-01

    Full Text Available Based on the theories of social representation (SC and Central Core (CC, a structural study was undertaken regarding the neologism hanseníase (Hansen's disease, the term adopted by Brazil's Ministry of Health in the 1970s. Carried out during 2001, this study interviewed eight hundred housewives residing in the Rio de Janeiro and Duque de Caxias municipalities. It found that Hansen's disease is part of a process of modernization of common thinking, anchored in the traditional representation of leprosy. This finding is understandable from the perspective that the central structure of a social representation has a historical determination, so short- and middle-term changes are not to be expected. Furthermore, there has been no ongoing investment in social marketing to make the new terminology more widely known. The authors discuss the relation between social representation and the concept of the history of mentalities.

  19. Validity of Hansen-Roach cross sections in low-enriched uranium systems

    International Nuclear Information System (INIS)

    Busch, R.D.; O'Dell, R.D.

    1991-01-01

    Within the nuclear criticality safety community, the Hansen-Roach 16 group cross section set has been the standard for use in k eff calculations over the past 30 years. Yet even with its widespread acceptance, there are still questions about its validity and adequacy, about the proper procedure for calculating the potential scattering cross section, σ p , for uranium and plutonium, and about the concept of resonance self shielding and its impact on cross sections. This paper attempts to address these questions. It provides a brief background on the Hansen-Roach cross sections. Next is presented a review of resonances in cross sections, self shielding of these resonances, and the use of σ p to characterize resonance self shielding. Three prescriptions for calculating σ p are given. Finally, results of several calculations of k eff on low-enriched uranium systems are provided to confirm the validity of the Hansen-Roach cross sections when applied to such systems. (Author)

  20. Theoretical models for Type I and Type II supernova

    International Nuclear Information System (INIS)

    Woosley, S.E.; Weaver, T.A.

    1985-01-01

    Recent theoretical progress in understanding the origin and nature of Type I and Type II supernovae is discussed. New Type II presupernova models characterized by a variety of iron core masses at the time of collapse are presented and the sensitivity to the reaction rate 12 C(α,γ) 16 O explained. Stars heavier than about 20 M/sub solar/ must explode by a ''delayed'' mechanism not directly related to the hydrodynamical core bounce and a subset is likely to leave black hole remnants. The isotopic nucleosynthesis expected from these massive stellar explosions is in striking agreement with the sun. Type I supernovae result when an accreting white dwarf undergoes a thermonuclear explosion. The critical role of the velocity of the deflagration front in determining the light curve, spectrum, and, especially, isotopic nucleosynthesis in these models is explored. 76 refs., 8 figs

  1. TESTING GARCH-X TYPE MODELS

    DEFF Research Database (Denmark)

    Pedersen, Rasmus Søndergaard; Rahbek, Anders

    2017-01-01

    We present novel theory for testing for reduction of GARCH-X type models with an exogenous (X) covariate to standard GARCH type models. To deal with the problems of potential nuisance parameters on the boundary of the parameter space as well as lack of identification under the null, we exploit...... a noticeable property of specific zero-entries in the inverse information of the GARCH-X type models. Specifically, we consider sequential testing based on two likelihood ratio tests and as demonstrated the structure of the inverse information implies that the proposed test neither depends on whether...... the nuisance parameters lie on the boundary of the parameter space, nor on lack of identification. Our general results on GARCH-X type models are applied to Gaussian based GARCH-X models, GARCH-X models with Student's t-distributed innovations as well as the integer-valued GARCH-X (PAR-X) models....

  2. Suspected resistance of MDT-MB in Multibacillary Leprosy of Hansen's disease: Two case reports

    Directory of Open Access Journals (Sweden)

    Yudo Irawan

    2016-12-01

    Full Text Available Resistance to multidrug therapy (MDT is one of the complications in the treatment of Hansen’s disease/Morbus Hansen (MH. There are two types of resistancy, which are primary and secondary. MDT-multibacillary (MB resistance must be suspected when no clinical improvement and the acid-fast bacilli (AFB index is not reduced after 12 months of therapy. A 28-year-old woman with paresthesia on her face, arms and legs since 2.5 years ago, accompanied by thickening of the right posterior tibial nerve. The AFB examination showed a bacteriological index (BI of 15/6 and morphological index (MI of 0.50%. The second case, a 42-year-old man came with paresthetic lesions on his face, chest, back, both arms and legs since 2 years ago, accompanied by thickening of ulnar and lateral peroneal nerve. The BI was 12/5 and the MI was 0.40%. Both patients were diagnosed with borderline lepromatous type of MH and received MDT-MB for 12 months. Diagnosis of suspected resistance was established because no clinical improvement or any significant decrease of AFB index after completing the MDT treatment. The patients had secondary resistance after polymerase chain reaction evaluation showed that they were still rifampicin-sensitive. There was clinical improvement and significant decrease in FAB index after the patients continued the MDT-MB treatment with 600 mg additional rifampicin. The diagnosis of bacterial resistance should be made based on clinical evaluation before completion of treatment. Based on the two case reports, the resistance suspected may be secondary. Treatment using additional regimen can be initiated once the resistance has been proven.

  3. Utilization of KENO-IV computer code with HANSEN-ROACH library

    International Nuclear Information System (INIS)

    Lima Barros, M. de; Vellozo, S.O.

    1982-01-01

    Several analysis with KENO-IV computer code, which is based in the Monte Carlo method, and the cross section library HANSEN-ROACH, were done, aiming to present the more convenient form to execute criticality calculations with this computer code and this cross sections. (E.G.) [pt

  4. Surviving the "School of Slavery": Acculturation in Sharon Draper's "Copper Sun" and Joyce Hansen's "The Captive"

    Science.gov (United States)

    Chandler, Karen Michele

    2016-01-01

    Although children's literature has long alluded to cultural connections between Africans and African Americans, very few texts establish clear lines of influence between particular African ethnic groups and African American characters and communities. Joyce Hansen's "The Captive" (1994) and Sharon Draper's "Copper Sun" (2006)…

  5. Tundmatud kohad ja asjade loomus / Katrine Gram Sloth, Johna Hansen ; intervjueerinud Laura Põld

    Index Scriptorium Estoniae

    Gram Sloth, Katrine, 1983-

    2016-01-01

    Taani kunstnik Katrine Gram Sloth ja Rootsi arhitekt Johna Hansen räägivad oma lapsepõlvest, kunstnikuteest, loomingust. Johna Hanseni jaapanipärasest einelaua installatsioonist "Laud" (2015-2016), Katrine Gram Slothi Islandil loodud teosest "Vista Revisited" (2015)

  6. Reproducibility of the Lauge-Hansen, Danis-Weber, and AO classifications for ankle fractures

    Directory of Open Access Journals (Sweden)

    Lucas Lopes da Fonseca

    Full Text Available ABSTRACT Objective: This study evaluated the reproducibility of the three main classifications of ankle fractures most commonly used in emergency clinical practice: Lauge-Hansen, Danis-Weber, and AO-OTA. The secondary objective was to assess whether the level of professional experience influenced the interobserver agreement for the classification of this pathology. Methods: The study included 83 digitized preoperative radiographic images of ankle fractures, in anteroposterior and lateral views, of different adults that had occurred between January and December 2013. For sample calculation, the estimated accuracy was approximately 15%, with a sampling error of 5% and a sampling power of 80%. The images were analyzed and classified by six different observers: two foot and ankle surgeons, two general orthopedic surgeons, and two-second-year residents in orthopedics and traumatology. The Kappa statistical method of multiple variances was used to assess the variations. Results: The Danis-Weber classification indicated that 40% of the agreements among all observers were good or excellent, whereas only 20% of good and excellent agreements were obtained using the AO and Lauge Hansen classifications. The Kappa index was 0.49 for the Danis-Weber classification, 0.32 for Lauge Hansen, and 0.38 for AO. Conclusion: The Hansen-Lauge classification presented the poorest interobserver agreement among the three systems. The AO classification demonstrated a moderate agreement and the Danis-Weber classification presented an excellent interobserver agreement index, regardless of professional experience.

  7. A Type Graph Model for Java Programs

    NARCIS (Netherlands)

    Rensink, Arend; Zambon, Eduardo

    2009-01-01

    In this report we present a type graph that models all executable constructs of the Java programming language. Such a model is useful for any graph-based technique that relies on a representation of Java programs as graphs. The model can be regarded as a common representation to which all Java

  8. A Type Graph Model for Java Programs

    NARCIS (Netherlands)

    Rensink, Arend; Zambon, Eduardo; Lee, D.; Lopes, A.; Poetzsch-Heffter, A.

    2009-01-01

    In this work we present a type graph that models all executable constructs of the Java programming language. Such a model is useful for any graph-based technique that relies on a representation of Java programs as graphs. The model can be regarded as a common representation to which all Java syntax

  9. Prevalência de olho seco em portadores de hanseníase de um hospital-colônia em Goiânia Prevalence of dry eye in Hansen's disease patients from a colony hospital in Goiânia, Brazil

    Directory of Open Access Journals (Sweden)

    Karys Carvalho Frazão

    2005-08-01

    (p=0.001. The mean age of the patients with Hansen's disease was 61.1±12.5 years and in the control group, it was 55.7±9.6 years. Fifteen (21.4% patients with Hansen's disease and four (13.3% controls presented with dry eye diagnosis (p=0.429. The lepromatous type (74.2% of Hansen's disease was the most prevalent and dry eye (66.7% was more frequent in this clinical form of the disease. CONCLUSION: The dry eye disease was more prevalent in patients with Hansen's disease, although the difference was not statistically significant.

  10. A Finite Model Property for Intersection Types

    Directory of Open Access Journals (Sweden)

    Rick Statman

    2015-03-01

    Full Text Available We show that the relational theory of intersection types known as BCD has the finite model property; that is, BCD is complete for its finite models. Our proof uses rewriting techniques which have as an immediate by-product the polynomial time decidability of the preorder <= (although this also follows from the so called beta soundness of BCD.

  11. A Dynamic Stall Model for Airfoils with Deformable Trailing Edges

    International Nuclear Information System (INIS)

    Andersen, Peter Bjoern; Gaunaa, Mac; Bak, Christian; Hansen, Morten Hartvig

    2007-01-01

    The present work contains an extension of the Beddoes-Leishman (B-L) type dynamic stall model, as described by Hansen et al. In this work a Deformable Trailing Edge Geometry (DTEG) has been added to the dynamic stall model. The model predicts the unsteady aerodynamic forces and moments on an airfoil section undergoing arbitrary motion in heave, lead-lag, pitch, Trailing Edge (TE) flapping. In the linear region, the model reduces to the inviscid model of Gaunaa, which includes the aerodynamic effect of a thin airfoil with a deformable camberline in inviscid flow. Therefore, the proposed model can be considered a crossover between the work of Gaunaa for the attached flow region and Hansen et al. The model will be compared to wind tunnel measurements from Velux described by Bak et al

  12. Achados fonoaudiológicos na hanseníase: considerações teóricas Speech-language findings on Hansen's disease: theoretical considerations

    Directory of Open Access Journals (Sweden)

    Victor Gandra Quintas

    2009-01-01

    Full Text Available A hanseníase é uma doença que tem altos níveis de incidência no Brasil. De origem bacteriana crônica, com alta infectividade e baixa patogenicidade, tem como hospedeiro primário o homem e como agente etiológico o Mycobacterium leprae. O bacilo de Hansen, como também é conhecido o agente, se acumula principalmente na pele, nos nervos periféricos e pares cranianos, levando a diversas lesões cutâneas, também à perda da condução neural e, consequentemente, a severas alterações anatômicas e funcionais nas extremidades do corpo, como membros e região orofacial. De acordo com estas premissas, foi realizada uma revisão da literatura com intuito de mostrar a fisiopatologia da doença e sua classificação de acordo com as suas manifestações. Desta forma, a literatura, por intermédio de alguns estudos, mostrou que esta doença pode provocar alterações que comprometem significativamente a voz, a audição, os órgãos fonoarticulatórios e as funções estomatognáticas, tornando-se assim, de grande relevância à Fonoaudiologia.Hansen's disease is a malady that has high incidence levels in Brazil. It has a chronic bacterial origin, with high infectivity and low pathogenicity, having the man as its primary host, and the Mycobacterium leprae as its etiological agent. The Hansen's bacillus, as it is known, accumulates mainly in the skin, the peripheral nerves and the cranial nerves pairs, causing many skin lesions, as well as loss of neural conduction and, consequently, severe anatomical and functional changes in the ends of the body, such as members and the orofacial region. Based on these premisses, it was carried out a literature review in order to show the pathophysiology of the disease and its classification according to its manifestations. The literature review showed, through some studies, that the disease might cause alterations that significantly compromise the voice, the hearing, the phonoarticulatory organs, and the

  13. Social representation of Hansen's disease thirty years after the term "leprosy" was replaced in Brazil.

    Science.gov (United States)

    Oliveira, Maria Leide Wand-del-Rey; Mendes, Carla Maria; Tardin, Rachel Tebaldi; Cunha, Mônica Duarte; Arruda, Angela

    2003-01-01

    Based on the theories of social representation (SC) and Central Core (CC), a structural study was undertaken regarding the neologism hanseniase (Hansen's disease), the term adopted by Brazil's Ministry of Health in the 1970s. Carried out during 2001, this study interviewed eight hundred housewives residing in the Rio de Janeiro and Duque de Caxias municipalities. It found that Hansen's disease is part of a process of modernization of common thinking, anchored in the additional representation of leprosy. This finding is understandable from the perspective that the central structure of a social representation has a historical determination, so short -and middle-term changes are not to be expected. Furthermore, there has been no ongoing investment in social marketing to make the new terminology more widely known. The authors discuss the relation between social representation and the concept of the history of mentalities.

  14. 22 tundi tõde ja õigust Anton Hansen Tammsaare moodi / Risto Berendson, Marika Rajamäe

    Index Scriptorium Estoniae

    Berendson, Risto, 1975-

    2008-01-01

    30. okt. kirjutati Anton Hansen Tammsaare sünniaastapäeva puhul alla lepingule, mis toob Vargamäele maratonetenduse kogu "Tõe ja õiguse" põhjal. Etendus toimub 21.-22. juunini. Kommenteerib Ülo Tonts

  15. 75 FR 49516 - Lewis and Clark National Wildlife Refuge and the Julia Butler Hansen Refuge for the Columbian...

    Science.gov (United States)

    2010-08-13

    ... that dredge-spoil islands provide benefits for wildlife. Julia Butler Hansen Refuge Alternative 1 Under... safety purposes, studying potential wilderness lands, developing a bicycling and hiking trail, installing...

  16. A Modern History of 'Imperial Medicine' Surrounding Hansen's Disease: Strategies to Manage Public Opinion in Modern Japanese Media.

    Science.gov (United States)

    Seo, Gijae

    2017-12-01

    The purpose of this study is to understand the reality of imperial medicine by exploring the strategic attitude of the Japanese authority targeting the public who were not patients of Hansen's disease. For this purpose, this study examines the mass media data related to Hansen's disease published in Korea and Japan during the Japanese colonial rule. Research on Hansen's disease can be divided into medical, sociohistorical, social welfare, and human rights approach. There are medical studies and statistics on the dissemination of medical information about Hansen's disease and management measures, the history of the management of the disease, guarantee of the rights of the patients and the welfare environment, and studies on the autobiographical, literary writings and oral statements on the life and psychological conflicts of the patients. Among existing research, the topics of the study on Hansen's disease under the Japanese colonial rule include the history of the Sorokdo Island Sanatorium, investigation on the forced labor of the patients in the island, human rights violations against the patients, oral memoirs of the patients and doctors who practiced at that time. All of these studies are important achievements regarding the research on the patients. An important study of Hansen's disease in modern Japan is the work of Hujino Utaka, which introduces the isolation of and discrimination against the patients of Hansen's disease. Hujino Utaka's study examines the annihilation of people with infectious diseases in Japan and its colonies by the imperial government, which was the consequence of the imperial medical policies, and reports on the isolation of Hansen's disease patients during the war. Although these researches are important achievements in the study of Hansen's disease in modernity, their focus has mainly been on the history of isolation and exploitation in the Sorokdo Island Sanatorium and discrimination against the patients within the sanatorium, which

  17. Empirical Asset Pricing: Eugene Fama, Lars Peter Hansen, and Robert Shiller

    OpenAIRE

    Campbell, John Y.

    2016-01-01

    The Nobel Memorial Prize in Economic Sciences for 2013 was awarded to Eugene Fama, Lars Peter Hansen, and Robert Shiller for their contributions to the empirical study of asset pricing. Some observers have found it hard to understand the common elements of the laureates research, preferring to highlight areas of disagreement among them. This paper argues that empirical asset pricing is a coherent enterprise, which owes much to the laureates seminal contributions, and that important themes in ...

  18. The phasor type model of SMES

    International Nuclear Information System (INIS)

    Shi, J.; Tang, Y.; Ren, L.; Li, J.; Chen, S.

    2009-01-01

    Superconducting magnetic energy storage (SMES) compensates the dynamic power for the power system through regulating the active and reactive currents between the SMES and the power system. To analyze the influence of SMES on the operation characteristic of the power system, a second-order equivalent model of SMES is adopted in the electromagnetic transient analysis of power system, but the model makes considerable simplifications for the dynamic characteristic of SMES. This paper proposed the phasor type model of SMES. The phasor model has the following characteristics: (1) the model does not considers the switching state of the power electronic converter, which can save the computing time and improve the simulation efficiency; (2) the model considers the performance of the superconducting magnet, the converter and the DC side capacitor, which can accurately reflect the dynamic response characteristics of SMES; and (3) the model includes detailed control system of SMES, which can implement different control methods to the SMES system and evaluate the control effect. Using MATLAB SIMULINK, the dynamic characteristic of the SMES phasor model is evaluated. Then, the phasor model is introduced into the power system stability analysis to analyze the application of SMES in damping out the power system.

  19. New approaches for modeling type Ia supernovae

    International Nuclear Information System (INIS)

    Zingale, Michael; Almgren, Ann S.; Bell, John B.; Day, Marcus S.; Rendleman, Charles A.; Woosley, Stan

    2007-01-01

    Type Ia supernovae (SNe Ia) are the largest thermonuclear explosions in the Universe. Their light output can be seen across great distances and has led to the discovery that the expansion rate of the Universe is accelerating. Despite the significance of SNe Ia, there are still a large number of uncertainties in current theoretical models. Computational modeling offers the promise to help answer the outstanding questions. However, even with today's supercomputers, such calculations are extremely challenging because of the wide range of length and timescales. In this paper, we discuss several new algorithms for simulations of SNe Ia and demonstrate some of their successes

  20. [Serological and cellular reactivity to mycobacterial proteins in Hansen's disease].

    Science.gov (United States)

    Rada, Elsa; Aranzazu, Nacarid; Rodríguez, Vestalia; Borges, Rafael; Convit, Jacinto

    2010-09-01

    The study was designed for evaluating immunological reactivity to various mycobacterial protein preparations using serological and cell-mediated immunological tests in patients with clinical leprosy signs, predominantly, with the multibacillary forms. All patients were adults with ages between 20 and 30 years. Fifty eight (n = 81) percent corresponded to Lepromatous Leprosy (LL), 29% (n = 41) to Borderline Lepromatous Leprosy (BL) and 10% (n = 41) to Borderline Borderline Leprosy (BB); only 3% were Borderline Tuberculoid (BT) patients: 74% males and 26% females. The most frequent reactional phenomenon was of the Erythema Nodosum (ENL) type. The mycobacterial proteins tested were: total crude Mycobacterium leprae antigens (MISA); Mycobacterium bovis (MbSA and excretion MbSA); partially purified excretion protein antigen, with a 30 kDa relative movility (Ml30); and recombinant M. leprae proteins (Mt70, Mb 65, Ml 36, 28, 18 and 10 kDa). Two of the recombinant proteins (Ml10 and Ml 36 kDa) presented a statiscally significant higher serological reactivity, directly related with a larger bacillary load (p = 0.0051 and 0.050 respectively). The 30 kDa protein was predominantly recognized by antibodies from multibacillary patients. Results show that mean antibody values were higher in non reactional patients when tested against complete proteins (MbSA and ex MbSA) when compared with the group of patients who presented reactional phenomena (p = 0.000567 and 0.000061, respectively). Comparing reactional with non reactional patients, it was seen that mean antibody values against complete proteins (MbSA and ex MbSA) were higher in non reactional individuals (p = 0.000567 and 0.000061, respectively). This same behavior occurred towards individual mycobacterial proteins (30, 10 and 36 kDa). The T lymphocyte prolypherative response in reactional and non reactional patients towards mycobacterial proteins (MlSA, Ml 10 kDa, MbSA, ex MbSA) was negative.

  1. Type I supernova models vs observations

    International Nuclear Information System (INIS)

    Weaver, T.A.; Axelrod, T.S.; Woosley, S.E.

    1980-01-01

    This paper explores tHe observational consequences of models for Type I supernovae based on the detonation (or deflagration) of the degenerate cores of white dwarfs or intermediate mass (approx. = 9 M/sub sun/) stars. Such nuclear burning can be initiated either at the center of the core or near its edge. The model examined in most detail is that of a 0.5M/sub sun/ C/O white dwarf which undergoes an edge-lit He/C/O detonation after accreting 0.62 M/sub sun/ of he at 10 -8 M/sub sun//yr. The light curve resulting from this model is found to be in excellent agreement with those observed for Type I supernovae, particularly those in the fast subclass. The physical processes involved in the detailed numerical calculations which lead to this conclusion are quantitatively elucidated by simple analytic models, and effects of uncertainties in the input physics are explored

  2. Edema na hanseníase: aspectos clínicos e terapêuticos

    OpenAIRE

    Valentini,Attilio; Nery,José A.C.; Salles,Ana Maria; Vieira,Leila M.M.; Sarno,Euzenir N.

    1999-01-01

    Durante o curso da hanseníase, o edema comumente descrito como um sintoma de estados reacionais, pode ocorrer. Tanto o diagnóstico como a terapêutica adequada são, freqüentemente, difíceis de conseguir e assim podem acarretar permanente dano aos membros inferiores. Em um ano de acompanhamento, pacientes hansenianos - 10 multibacilares e 1 paucibacilar -, que foram submetidos a um protocolo clínico para o diagnóstico e classificação histopatológica, apresentaram clinicamente edema, localizado ...

  3. Tests on thirteen navy type model propellers

    Science.gov (United States)

    Durand, W F

    1927-01-01

    The tests on these model propellers were undertaken for the purpose of determining the performance coefficients and characteristics for certain selected series of propellers of form and type as commonly used in recent navy designs. The first series includes seven propellers of pitch ratio varying by 0.10 to 1.10, the area, form of blade, thickness, etc., representing an arbitrary standard propeller which had shown good results. The second series covers changes in thickness of blade section, other things equal, and the third series, changes in blade area, other things equal. These models are all of 36-inch diameter. Propellers A to G form the series on pitch ratio, C, N. I. J the series on thickness of section, and K, M, C, L the series on area. (author)

  4. Deprescribing for frail older people - Learning from the case of Mrs. Hansen.

    Science.gov (United States)

    Granas, Anne Gerd; Stendal Bakken, Marit; Ruths, Sabine; Taxis, Katja

    2017-07-13

    Drug treatment is often an essential part in treatment and prevention of diseases in older people, but there is much concern about inappropriate medication use. This paper aims to describe the complexity of medication safety issues and clinical judgments when optimizing prescribing in older individuals. It uses the case of Mrs. Hansen, an aged nursing home resident, to illustrate the facilitators and barriers of this process. With decreasing life expectancy, medication use should shift from cure to care, focusing on symptomatic treatment to increase the patient's well-being. In Mrs. Hansen's case, the number of (potentially) dangerous medications were reduced, and non-pharmacological alternatives were considered. There were some medicines added, as underprescribing can also be a problem in older people. Deprescribing long-standing treatment can be interpreted by the patient and family as "giving up hope". More clinical evidence and practical communication tools are needed to guide deprescribing decisions, taking medical and patient-centered priorities into account. Studies evaluating such interventions should select outcome measures that are particularly relevant for frail old individuals. Copyright © 2017. Published by Elsevier Inc.

  5. Dialogens kunstner : Dialog og performativitet hos Martin A. Hansen – med særligt henblik på hans ikke-fiktive forfatterskab

    NARCIS (Netherlands)

    Bay, A.

    2017-01-01

    This thesis is about the Danish writer Martin A. Hansen (1909-1955) and focusses on his essayistic works in which he acts as an engaged – but more importantly – also as a dialogical social critic. I have primarily looked into the way Martin A. Hansen (MAH) uses dialogue in his writings about modern

  6. 42 CFR 22.1 - Duty at a station of the Service devoted to the care of Hansen's disease patients; additional pay.

    Science.gov (United States)

    2010-10-01

    ... care of Hansen's disease patients and who continues to be assigned to such duty, shall receive special... 42 Public Health 1 2010-10-01 2010-10-01 false Duty at a station of the Service devoted to the care of Hansen's disease patients; additional pay. 22.1 Section 22.1 Public Health PUBLIC HEALTH...

  7. Læremiddeltjek af Fandange - dansk for 5. klasse af Trine May og Susanne Arne-Hansen

    DEFF Research Database (Denmark)

    Christensen, Mette Vedsgaard

    2013-01-01

    Fandango 5 er skrevet af Trine May og Susanne Arne-Hansen og er første gang udgivet i 2009. Systemet er siden kommet i flere oplag. Fandango – dansk for 5. klasse består af en grundbog (264 sider) Arbejdsbog A (64 sider) Arbejdsbog B (64 sider), en lærervejledning (ca. 220 sider) og en hjemmeside...

  8. Environmental assessment related to the operation of Hansen uranium mill project, WM-24, Cyprus Mines Corporation

    International Nuclear Information System (INIS)

    1981-01-01

    An environmental assessment was prepared by the staff of the U.S. Nuclear Regulatory Commission, Office of Nuclear Material Safety and Safeguards, in response to a request for technical assistance from the State of Colorado in connection with licensing action on the proposed Cyprus Mines Corporation, Hansen uranium project. The major components of discussion are (1) a summary and recommended licensing conditions, (2) a description of the site environment and the proposed facility operation as well as alternatives in comparison with NRC's performance objectives for tailings management, and (3) a radiological assessment for estimating the facility's compliance with 10 CFR 20 and 40 CFR 190 dose regulations. The NRC recommends licensing the proposed mill subject to stipulated license conditions

  9. The Exile of Hansen's Disease Patients to Moloka'i: A Diffusion of Innovations Perspective.

    Science.gov (United States)

    Pitman Harris, Adrea; Matusitz, Jonathan

    2016-07-01

    This article analyzes the exile of patients with Hansen's disease (leprosy) to Moloka'i (Hawaii) by applying the diffusion of innovations (DoI) theory. Developed by Rogers, DoI posits that an innovation (i.e., idea, movement, or trend) is initiated within a culture. Then, it is diffused via particular channels across diverse cultures. Instead of evolving independently, innovations diffuse from one culture to another through various forms of contact and communication. In the context of this analysis, the objective is to examine how the diffusion of certain ideas, namely, abolishing the stigma associated with leprosy, could have improved the lives of Hawaiians. An important premise of this article is that the Hawaiian government barely applied the tenets of DoI, which is the reason why many people lost their lives. So, this article seeks to explore what could have been done to improve their situation and what pitfalls should be avoided in the future.

  10. Necrose de canto medial associado a hanseníase virchowiana: relato de caso

    Directory of Open Access Journals (Sweden)

    Leiser Franco

    2010-12-01

    Full Text Available O caso em relato aborda uma etiologia rara para necrose de canto medial da pálpebra com comprometimento do sistema canalicular em uma paciente em tratamento para hanseníase virchowiana. O exame histopatológico da lesão necrótica evidenciou reação inflamatória granulomatosa com acúmulo de histiócitos e presença de bacilos álcool-ácido resistentes. Após tratamento medicamentoso a paciente apresentou uma evolução favorável com recuperação espontânea da arquitetura do canto medial, porém com destruição total do sistema canalicular.

  11. Revisiting hansen's disease: Recognizing the many neurodermatologic faces and its diagnostic challenges

    Directory of Open Access Journals (Sweden)

    Bhaskara P Shelley

    2018-01-01

    Full Text Available Hansen's disease (HD looms still as a public health problem. Conventional wisdom and teaching largely view HD as a predominantly dermatologic disorder with much emphasis in the dermatology postgraduate curriculum. This review attempts to reorient this view and reemphasize that HD has primarily neurologic underpinnings since Mycobacterium leprae is an intracellular neurotropic bacterium. The main thrust of this article would, therefore, be a neurologist's perspective of HD. The cutaneous manifestations of HD are the sequelae of the neurobiology of M. leprae, its selective predilection to human Schwann cells, neurovascular bundle and its localization in the intracutaneous nerve plexus of the skin. We discuss the nuances of HD as a “great imitator,” the many faces of its neurodermatologic clinical presentation, the neurologic basis of HD clinical examination, and its diagnostic and therapeutic challenges.

  12. Family Health Strategy professionals' view on the effects of Hansen's disease training

    Directory of Open Access Journals (Sweden)

    Ana Lúcia Alves de Souza

    2015-08-01

    Full Text Available OBJECTIVEEvaluating how professionals of family health teams from three municipalities of Pernambuco perceive and interpret the effects of Hansen's disease training.METHODSA qualitative study using the perspective of Habermas. Six focus groups, totaling 33 nurses and 22 doctors were formed. The guide consisted of: reactions to training, learning, transfer of knowledge and organizational results.RESULTSThere were recurrent positive opinions on instructor performance, course materials, and an alert attitude to the occurrence of cases; the negative points were about lack of practical teaching, a lot of information in a short period of time and little emphasis on basic content. Low perceived self-efficacy and low locus of control, ambiguity, conflict of skills and the lack of support for the learning application. Nurses showed greater dissatisfaction with the organizational support.CONCLUSIONThe low effectiveness of training reveals the need to negotiate structured training from work problematization, considering performance conditions.

  13. Edema na hanseníase: aspectos clínicos e terapêuticos

    Directory of Open Access Journals (Sweden)

    Valentini Attilio

    1999-01-01

    Full Text Available Durante o curso da hanseníase, o edema comumente descrito como um sintoma de estados reacionais, pode ocorrer. Tanto o diagnóstico como a terapêutica adequada são, freqüentemente, difíceis de conseguir e assim podem acarretar permanente dano aos membros inferiores. Em um ano de acompanhamento, pacientes hansenianos - 10 multibacilares e 1 paucibacilar -, que foram submetidos a um protocolo clínico para o diagnóstico e classificação histopatológica, apresentaram clinicamente edema, localizado ou sistêmico. Entre estes pacientes, cinco apresentaram simultaneamente outros sintomas de reação, 4 foram classificados como reação Tipo I e um como reação tipo II. Por outro lado, três pacientes não apresentaram reação no momento do diagnóstico, mas desenvolveram alguns aspectos de reação posteriormente (2 tiveram neurite e um teve reação tipo I. Os edemas observados precedendo ou associados a quadros reacionais apresentaram ótima resposta clínica às drogas de ação anti-inflamatória (corticóide, talidomida e pentoxifilina utilizadas para o tratamento dos estados reacionais, na ausência de qualquer outro tratamento normalmente usado para edema. Embora necessitem ser confirmados por estudos controlados, estes dados sugerem fortemente que mecanismos imunológicos estejam envolvidos na fisiopatologia dos edemas na hanseníase.

  14. Epidemiologia da hanseníase em coorte de contatos intradomiciliares no Rio de Janeiro (1987-1991

    Directory of Open Access Journals (Sweden)

    Matos Haroldo José de

    1999-01-01

    Full Text Available Este trabalho foi desenvolvido para estudar os fatores que influem no adoecimento dos contatos intradomiciliares de hanseníase. Foi estabelecida uma coorte de contatos intradomiciliares de hanseníase no setor de Hanseníase da Fiocruz, no Rio de Janeiro. Entre 1987 e 1991, em que foram acompanhados 670 contatos saudáveis, a taxa de incidência por pessoa-ano de follow-up foi de 0,01694. Porém, houve variação com o tempo de acompanhamento de cada indivíduo, sendo de 0,06385 ao final do primeiro ano, de 0,03299 ao final do segundo, 0,02370 ao final do terceiro, 0,018622 ao final do quarto e 0,01694 ao final do período. Foi especificado um modelo de regressão logística para os indivíduos acompanhados nos primeiros cinco anos, envolvendo 758 contatos, incluindo nessa situação os casos co-prevalentes. O risco de incidência de hanseníase está relacionado com a negatividade do teste de Mitsuda, com OR de 3,093 (IC95% = 1,735-5,514, com a vacinação pelo BCG, OR de 0,3802 (IC95% = 0,2151-0,66719, e com a forma multibacilar do caso-índice, OR de 2,547 (IC95% = 1,249-5,192. Os resultados indicam que a incidência da hanseníase em contatos está associada à forma multibacilar da doença e aos fatores imunes dos contatos.

  15. A Realizability Model for Impredicative Hoare Type Theory

    DEFF Research Database (Denmark)

    Petersen, Rasmus Lerchedal; Birkedal, Lars; Nanevski, Alexandar

    2008-01-01

    We present a denotational model of impredicative Hoare Type Theory, a very expressive dependent type theory in which one can specify and reason about mutable abstract data types. The model ensures soundness of the extension of Hoare Type Theory with impredicative polymorphism; makes the connections...... to separation logic clear, and provides a basis for investigation of further sound extensions of the theory, in particular equations between computations and types....

  16. Opiniões sobre a doença entre membros da rede social de pacientes de hanseníase no Recife Opinions about Hansen's disease among the members of patients' social network in Recife

    Directory of Open Access Journals (Sweden)

    Katia V. de O. Feliciano

    1997-02-01

    Full Text Available O presente artigo descreve um estudo realizado no Recife, Brasil, entre novembro de 1993 e julho de 1994, com a finalidade de explorar as opiniões dos membros da rede social (por exemplo, familiares, amigos e vizinhos de portadores de hanseníase na avaliação, interpretação e manejo das manifestações corporais da doença na trajetória que levou ao diagnóstico. A amostra constou de 93 membros da rede social, com idade entre 20 e 70 anos, que apoiaram o curso de ação de 83 pacientes diagnosticados no período do estudo. A análise buscou detectar variáveis capazes de discriminar os membros da rede de apoio dos pacientes de hanseníase classificados como casos (presença de incapacidades ou lesões precursoras de incapacidades ou controles. O estudo evidenciou a escassez de informações sobre a transmissão da hanseníase e revelou um quadro transicional onde se confrontam expectativa de cura e uma visão estigmatizante das conseqüências da doença. Apenas uma quarta parte dos sujeitos do estudo suspeitou, antes do diagnóstico, que o paciente era portador de hanseníase, o que sugere baixa percepção do risco representado pela doença e reforça a concepção da invisibilidade das suas manifestações corporais. Os resultados mostram um perfil de percepção e manejo da hanseníase que pode facilitar a propagação da doença e a instalação ou agravamento das suas conseqüências físicas e sociais.This article describes a study done in Recife, Brazil, between November 1993 and July 1994 to explore the opinions of the members of the social network (for example, family members, friends, and neighbors of carriers of Hansen's disease regarding their estimation, interpretation, and management of physical manifestations of the disease in the time leading up to diagnosis. The sample consisted of 93 members of the social network, ranging in age between 20 and 70 years, who supported the course of action of 83 patients diagnosed in the

  17. Achieving concentrated graphene dispersions in water/acetone mixtures by the strategy of tailoring Hansen solubility parameters

    International Nuclear Information System (INIS)

    Yi Min; Shen Zhigang; Zhang Xiaojing; Ma Shulin

    2013-01-01

    Although exfoliating graphite to give graphene paves a new way for graphene preparation, a general strategy of low-boiling-point solvents and high graphene concentration is still highly required. In this study, using the strategy of tailoring Hansen solubility parameters (HSP), a method based on exfoliation of graphite in water/acetone mixtures is demonstrated to achieve concentrated graphene dispersions. It is found that in the scope of blending two mediocre solvents, tailoring the HSP of water/acetone mixtures to approach the HSP of graphene could yield graphene dispersions at a high concentration of up to 0.21 mg ml -1 . The experimentally determined optimum composition of the mixtures occurs at an acetone mass fraction of ∼75%. The trend of concentration varying with mixture compositions could be well predicated by the model, which relates the concentration to the mixing enthalpy within the scope of HSP theory. The resultant dispersion is highly stabilized. Atomic force microscopic statistical analysis shows that up to ∼50% of the prepared nanosheets are less than 1 nm thick after 4 h sonication and 114g centrifugation. Analyses based on diverse characterizations indicate the graphene sheets to be largely free of basal plane defects and oxidation. The filtered films are also investigated in terms of their electrical and optical properties to show reasonable conductivity and transparency. The strategy of tailoring HSP, which can be easily extended to various solvent systems, and water/acetone mixtures here, extends the scope for large-scale production of graphene in low-boiling-point solutions.

  18. A dynamic stall model for airfoils with deformable trailing edges

    DEFF Research Database (Denmark)

    Andersen, Peter Bjørn; Gaunaa, Mac; Bak, Dan Christian

    2007-01-01

    on an airfoil section undergoing arbitrary motion in heave, lead-lag, pitch, Trailing Edge (TE) flapping. In the linear region, the model reduces to the inviscid model of Gaunaa [4], which includes the aerodynamic effect of a thin airfoil with a deformable camberline in inviscid flow. Therefore, the proposed......The present work contains an extension of the Beddoes-Leishman (B-L) type dynamic stall model, as described by Hansen et al. [7]. In this work a Deformable Trailing Edge Geometry (DTEG) has been added to the dynamic stall model. The model predicts the unsteady aerodynamic forces and moments...

  19. Specific Type of Knowledge Map: Mathematical Model

    OpenAIRE

    Milan, Houška; Martina, Beránková

    2005-01-01

    The article deals with relationships between mathematical models and knowledge maps. The goal of the article is to suggest how to use the mathematical model as a knowledge map and/or as a part (esp. the inference mechanism) of the knowledge system. The results are demonstrated on the case study, when the knowledge from a story is expressed by mathematical model. The model is used for both knowledge warehousing and inferencing new artificially derived knowledge.

  20. Logic model needs for diverse facility types

    International Nuclear Information System (INIS)

    Wilson, J.R.

    1995-01-01

    This paper compares the characteristics of fault trees (where initiators are developed within the fault tree) vs. event trees (where the nodes are developed by fault trees). This comparison requires some additional discussion on the subtlety of initiators. Difficulties when analyzing various reactor-type and processing facilities are discussed to illustrate the particular characteristics of each type of logic. The intent is to allow probabilistic risk assessment (PRA) analysts to be open-quotes bi-logical,close quotes or equally comfortable with event-tree or fault-tree logic, knowing when to apply each

  1. Mathematical model of compact type evaporator

    Science.gov (United States)

    Borovička, Martin; Hyhlík, Tomáš

    2018-06-01

    In this paper, development of the mathematical model for evaporator used in heat pump circuits is covered, with focus on air dehumidification application. Main target of this ad-hoc numerical model is to simulate heat and mass transfer in evaporator for prescribed inlet conditions and different geometrical parameters. Simplified 2D mathematical model is developed in MATLAB SW. Solvers for multiple heat and mass transfer problems - plate surface temperature, condensate film temperature, local heat and mass transfer coefficients, refrigerant temperature distribution, humid air enthalpy change are included as subprocedures of this model. An automatic procedure of data transfer is developed in order to use results of MATLAB model in more complex simulation within commercial CFD code. In the end, Proper Orthogonal Decomposition (POD) method is introduced and implemented into MATLAB model.

  2. Computer modeling of Cannabinoid receptor type 1

    Directory of Open Access Journals (Sweden)

    Sapundzhi Fatima

    2018-01-01

    Full Text Available Cannabinoid receptors are important class of receptors as they are involved in various physiological processes such as appetite, pain-sensation, mood, and memory. It is important to design receptor-selective ligands in order to treat a particular disorder. The aim of the present study is to model the structure of cannabinoid receptor CB1 and to perform docking between obtained models and known ligands. Two models of CBR1 were prepared with two different methods (Modeller of Chimera and MOE. They were used for docking with GOLD 5.2. It was established a high correlation between inhibitory constant Ki of CB1 cannabinoid ligands and the ChemScore scoring function of GOLD, which concerns both models. This suggests that the models of the CB1 receptors obtained could be used for docking studies and in further investigation and design of new potential, selective and active cannabinoids with the desired effects.

  3. Saladused ja narri kuju Anton Hansen Tammsaare poeetikas. Secrets and the Figure of the Fool in Anton Hansen Tammsaare’s Poetics

    Directory of Open Access Journals (Sweden)

    Maarja Vaino

    2012-04-01

    Full Text Available This article examines the poetics of Anton Hansen Tammsaare’s texts with a focus on the manifestation and function of the irrational. Tammsaare has been regarded first and foremost as the author of earthy, realistic novels about the peasantry; as a writer he has been deemed a rationalist and a skeptic. However, the criticism of the 1930s also recognizes a dimension of irrationality in his works. A variety of features are listed through which Tammsaare communicates the non-realistic aspects of his characters` perception of the world: the creation of a mysterious quality in the text; paradoxical situations and trains of thought; impulsive and intuitive behaviour on the part of the characters. This line of research was interrupted after World War II: in Soviet literary scholarship, topics that diverged from realism, or „closeness to life” were frowned upon. Therefore the dimension of irrationality in Tammsaare’s works has yet to receive in-depth consideration. This article seeks to develop the insights of earlier, pre-war Tammsaare critics and carry them further. Closer examination is devoted to the secret as an impetus for events in Tammsaare’s texts, as well as to that dimension of the irrational in Tammsaare which is expressed through the archetype of the fool. Though secrets in the abstract sense could be seen as an aspect influencing interpersonal relations between characters, Tammsaare uses the figure of the fool to bring characters into his works whose strange and incomprehensible behaviour keeps events „going”, creating more and more complicated or insoluble situations, and throwing the well-ordered world into chaos. Tammsaare characteristically constructs his fictional world in such a way that externally plausible circumstances underscore the behaviour patterns of characters in a state of psychological tension, thereby bringing their internal and unconscious worlds into view. What emerges out of this process is a particular

  4. Predictor variable resolution governs modeled soil types

    Science.gov (United States)

    Soil mapping identifies different soil types by compressing a unique suite of spatial patterns and processes across multiple spatial scales. It can be quite difficult to quantify spatial patterns of soil properties with remotely sensed predictor variables. More specifically, matching the right scale...

  5. Modelling of Box Type Solar Cooker Performance in a Tropical ...

    African Journals Online (AJOL)

    Thermal performance model of box type solar cooker with loaded water is presented. The model was developed using the method of Funk to estimate cooking power in terms of climatic and design parameters for box type solar cooker in a tropical environment. Coefficients for each term used in the model were determined ...

  6. Spectra of definite type in waveguide models

    Czech Academy of Sciences Publication Activity Database

    Lotoreichik, Vladimir; Siegl, Petr

    2017-01-01

    Roč. 145, č. 3 (2017), s. 1231-1246 ISSN 0002-9939 R&D Projects: GA ČR(CZ) GA14-06818S Institutional support: RVO:61389005 Keywords : spectral points of definite and of type pi * weakly coupled bound states * pertrubations of essential spectrum * PT-symmetric waveguide Subject RIV: BE - Theoretical Physics OBOR OECD: Applied mathematics Impact factor: 0.679, year: 2016

  7. Comparison of Hansen--Roach and ENDF/B-IV cross sections for 233U criticality calculations

    International Nuclear Information System (INIS)

    McNeany, S.R.; Jenkins, J.D.

    1976-01-01

    A comparison is made between criticality calculations performed using ENDF/B-IV cross sections and the 16-group Hansen-- Roach library at ORNL. The area investigated is homogeneous systems of highly enriched 233 U in simple geometries. Calculations are compared with experimental data for a wide range of H/ 233 U ratios. Results show that calculations of k/sub eff/ made with the Hansen--Roach cross sections agree within 1.5 percent for the experiments considered. Results using ENDF/B-IV cross sections were in good agreement for well-thermalized systems, but discrepancies up to 7 percent in k/sub eff/ were observed in fast and epithermal systems

  8. Physical and meteorological data from HELLAND-HANSEN from the Kara Sea from 08 June 1966 to 21 June 1966 (NODC Accession 9600035)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Physical and meteorological data from HELLAND-HANSEN from the Kara Sea. Data were collected by the University of Bergen Geophysical Institute from 08 June 1966 to 21...

  9. Hydrodynamics of Mangrove Root-Type Models

    Science.gov (United States)

    Kazemi, Amirkhosro

    Mangrove trees play a prominent role in coastal tropic and subtropical regions, providing habitat for many organisms and protecting shorelines against storm surges, high winds, erosion, and tsunamis. The motivation of this proposal is to understand the complex interaction of mangrove roots during tidal flow conditions using simplified physical models. In this dissertation, the mangrove roots were modeled with a circular array of cylinders with different porosities and spacing ratios. In addition, we modeled the flexibility of the roots by attaching rigid cylinders to hinge connectors. The models were tested in a water tunnel for a range of Reynolds number from 2200 to 11000. Additionally, we performed 2D flow visualization for different root models in a flowing soap film setup. We measured drag force and the instantaneous streamwise velocity downstream of the models. Furthermore, we investigated the fluid dynamics downstream of the models using a 2-D time-resolved particle image velocimetry (PIV), and flow visualization. The result was analyzed to present time-averaged and time-resolved flow parameters including the velocity distribution, vorticity, streamline, Reynolds shear stress and turbulent kinetic vi energy. We found that the frequency of the vortex shedding increases as the diameter of the small cylinders decreases while the patch diameter is constant, therefore increasing the Strouhal number, St = fD/U. By comparing the change of Strouhal numbers with a single solid cylinder, we introduced a new length scale, the "effective diameter". In addition, the effective diameter of the patch decreases as the porosity increases. In addition, patch drag decreases linearly as the spacing ratio increases. For flexible cylinders, we found that a decrease in stiffness increases both patch drag and the wake deficit behind the patch in a similar fashion as increasing the blockage of the patch. The average drag coefficient decreased with increasing Reynolds number and with

  10. Modelling radiative heat transfer inside a basin type solar still

    International Nuclear Information System (INIS)

    Madhlopa, A.

    2014-01-01

    Radiative heat transfer inside a basin type solar still has been investigated using two models with (model 1) and without (model 2) taking into account optical view factors. The coefficient of radiative heat exchange (h r,w-gc ) between the water and cover surfaces of a practical solar still was computed using the two models. Simulation results show that model 1 yields lower values of h r,w-gc and the root mean square error than model 2. It is therefore concluded that the accuracy of modelling the performance of a basin-type solar still can be improved by incorporating view factors. - Highlights: • Radiative heat transfer in a basin type solar still has been investigated. • Two models with and without view factors were used. • The model with view factors exhibits a lower magnitude of root mean square error. • View factors affect the accuracy of modelling the performance of the solar still

  11. Type-I integrable quantum impurities in the Heisenberg model

    Energy Technology Data Exchange (ETDEWEB)

    Doikou, Anastasia, E-mail: adoikou@upatras.gr

    2013-12-21

    Type-I quantum impurities are investigated in the context of the integrable Heisenberg model. This type of defects is associated to the (q)-harmonic oscillator algebra. The transmission matrices associated to this particular type of defects are computed via the Bethe ansatz methodology for the XXX model, as well as for the critical and non-critical XXZ spin chain. In the attractive regime of the critical XXZ spin chain the transmission amplitudes for the breathers are also identified.

  12. Type-I integrable quantum impurities in the Heisenberg model

    International Nuclear Information System (INIS)

    Doikou, Anastasia

    2013-01-01

    Type-I quantum impurities are investigated in the context of the integrable Heisenberg model. This type of defects is associated to the (q)-harmonic oscillator algebra. The transmission matrices associated to this particular type of defects are computed via the Bethe ansatz methodology for the XXX model, as well as for the critical and non-critical XXZ spin chain. In the attractive regime of the critical XXZ spin chain the transmission amplitudes for the breathers are also identified

  13. Type-2 fuzzy logic uncertain systems’ modeling and control

    CERN Document Server

    Antão, Rómulo

    2017-01-01

    This book focuses on a particular domain of Type-2 Fuzzy Logic, related to process modeling and control applications. It deepens readers’understanding of Type-2 Fuzzy Logic with regard to the following three topics: using simpler methods to train a Type-2 Takagi-Sugeno Fuzzy Model; using the principles of Type-2 Fuzzy Logic to reduce the influence of modeling uncertainties on a locally linear n-step ahead predictor; and developing model-based control algorithms according to the Generalized Predictive Control principles using Type-2 Fuzzy Sets. Throughout the book, theory is always complemented with practical applications and readers are invited to take their learning process one step farther and implement their own applications using the algorithms’ source codes (provided). As such, the book offers avaluable referenceguide for allengineers and researchers in the field ofcomputer science who are interested in intelligent systems, rule-based systems and modeling uncertainty.

  14. Towards an Existential Types Model for Java with Wildcards

    DEFF Research Database (Denmark)

    Cameron, Nicholas; Drossopoulou, Sophia; Ernst, Erik

    2007-01-01

    Wildcards extend Java generics by softening the mismatch between subtype and parametric polymorphism. Although they are a key part of the Java 5.0 programming language, a type system including wildcards has never been proven type sound. Wildcards have previously been formalised as existential types....... In this paper we extend FGJ, a featherweight formalisation of Java with generics, with existential types. We prove that this calculus, ExistsJ, is type sound, and illustrate how it models wildcards in the Java Programming Language. ExistsJ is not a full model for Java wildcards, because it does not support...... lower bounds for wildcards. We discuss why ExistsJ can not be easily extended with lower bounds, and how full Java wildcards could be modelled in a type sound way....

  15. Lanchester-Type Models of Warfare, Volume II

    OpenAIRE

    Taylor, James G.

    1980-01-01

    This monograph is a comprehensive treatist on Lanchester-type models of warfare, i.e. differential-equation models of attrition in force-on-force combat operations. Its goal is to provide both an introduction to and current-state-of-the-art overview of Lanchester-type models of warfare as well as a comprehensive and unified in-depth treatment of them. Both deterministic as well as stochastic models are considered. Such models have been widely used in the United States and elsewhere for the...

  16. Internal Universes in Models of Homotopy Type Theory

    DEFF Research Database (Denmark)

    Licata, Daniel R.; Orton, Ian; Pitts, Andrew M.

    2018-01-01

    We show that universes of fibrations in various models of homotopy type theory have an essentially global character: they cannot be described in the internal language of the presheaf topos from which the model is constructed. We get around this problem by extending the internal language with a mo...... that the interval in cubical sets does indeed have. This leads to a completely internal development of models of homotopy type theory within what we call crisp type theory.......We show that universes of fibrations in various models of homotopy type theory have an essentially global character: they cannot be described in the internal language of the presheaf topos from which the model is constructed. We get around this problem by extending the internal language...

  17. Types of electric field distribution and corresponding types of convection in the polar ionosphere. Model

    International Nuclear Information System (INIS)

    Uvarov, V.M.; Barashkov, P.D.

    1989-01-01

    All types of distributions, known due to the experiment, for Ee-m electric field evening-morning component along morning-evening meridian are reproduced and corresponding types of convection in polar ionosphere are calculated on the basis of model of continuous distribution of E large-scale electric fields. Two-, three- and four-whirl types of convection are realized depending on conditions in interplanetary medium

  18. Improvement of TNO type trailing edge noise models

    DEFF Research Database (Denmark)

    Fischer, Andreas; Bertagnolio, Franck; Aagaard Madsen, Helge

    2016-01-01

    . It is computed by solving a Poisson equation which includes flow turbulence cross correlation terms. Previously published TNO type models used the assumption of Blake to simplify the Poisson equation. This paper shows that the simplification should not be used. We present a new model which fully models...

  19. Improvement of TNO type trailing edge noise models

    DEFF Research Database (Denmark)

    Fischer, Andreas; Bertagnolio, Franck; Aagaard Madsen, Helge

    2017-01-01

    . It is computed by solving a Poisson equation which includes flow turbulence cross correlation terms. Previously published TNO type models used the assumption of Blake to simplify the Poisson equation. This paper shows that the simplification should not be used. We present a new model which fully models...

  20. A note on tilted Bianchi type VIh models: the type III bifurcation

    Science.gov (United States)

    Coley, A. A.; Hervik, S.

    2008-10-01

    In this note we complete the analysis of Hervik, van den Hoogen, Lim and Coley (2007 Class. Quantum Grav. 24 3859) of the late-time behaviour of tilted perfect fluid Bianchi type III models. We consider models with dust, and perfect fluids stiffer than dust, and eludicate the late-time behaviour by studying the centre manifold which dominates the behaviour of the model at late times. In the dust case, this centre manifold is three-dimensional and can be considered a double bifurcation as the two parameters (h and γ) of the type VIh model are varied. We therefore complete the analysis of the late-time behaviour of tilted ever-expanding Bianchi models of types I VIII.

  1. Modeling terminal ballistics using blending-type spline surfaces

    Science.gov (United States)

    Pedersen, Aleksander; Bratlie, Jostein; Dalmo, Rune

    2014-12-01

    We explore using GERBS, a blending-type spline construction, to represent deform able thin-plates and model terminal ballistics. Strategies to construct geometry for different scenarios of terminal ballistics are proposed.

  2. Type D Personality : a five-factor model perspective

    NARCIS (Netherlands)

    de Fruyt, F.; Denollet, J.K.L.

    2002-01-01

    This study investigated the position of Type D (high Negative Affectivity and high Social Inhibition) within the Five-Factor Model (FFM) of personality. A sample of 155 healthy subjects were administered the Type D Scale and the NEO-FFI, assessing the FFM traits. Subjects also filled out the General

  3. On a Boltzmann-type price formation model

    KAUST Repository

    Burger, Martin

    2013-06-26

    In this paper, we present a Boltzmann-type price formation model, which is motivated by a parabolic free boundary model for the evolution of price presented by Lasry and Lions in 2007. We discuss the mathematical analysis of the Boltzmann-type model and show that its solutions converge to solutions of the model by Lasry and Lions as the transaction rate tends to infinity. Furthermore, we analyse the behaviour of the initial layer on the fast time scale and illustrate the price dynamics with various numerical experiments. © 2013 The Author(s) Published by the Royal Society. All rights reserved.

  4. On a Boltzmann-type price formation model

    KAUST Repository

    Burger, Martin; Caffarelli, Luis A.; Markowich, Peter A.; Wolfram, Marie Therese

    2013-01-01

    In this paper, we present a Boltzmann-type price formation model, which is motivated by a parabolic free boundary model for the evolution of price presented by Lasry and Lions in 2007. We discuss the mathematical analysis of the Boltzmann-type model and show that its solutions converge to solutions of the model by Lasry and Lions as the transaction rate tends to infinity. Furthermore, we analyse the behaviour of the initial layer on the fast time scale and illustrate the price dynamics with various numerical experiments. © 2013 The Author(s) Published by the Royal Society. All rights reserved.

  5. Stochastic epidemic-type model with enhanced connectivity: exact solution

    International Nuclear Information System (INIS)

    Williams, H T; Mazilu, I; Mazilu, D A

    2012-01-01

    We present an exact analytical solution to a one-dimensional model of the susceptible–infected–recovered (SIR) epidemic type, with infection rates dependent on nearest-neighbor occupations. We use a quantum mechanical approach, transforming the master equation via a quantum spin operator formulation. We calculate exactly the time-dependent density of infected, recovered and susceptible populations for random initial conditions. Our results compare well with those of previous work, validating the model as a useful tool for additional and extended studies in this important area. Our model also provides exact solutions for the n-point correlation functions, and can be extended to more complex epidemic-type models

  6. A model of PCF in guarded type theory

    DEFF Research Database (Denmark)

    Paviotti, Marco; Møgelberg, Rasmus Ejlers; Birkedal, Lars

    2015-01-01

    Guarded recursion is a form of recursion where recursive calls are guarded by delay modalities. Previous work has shown how guarded recursion is useful for constructing logics for reasoning about programming languages with advanced features, as well as for constructing and reasoning about element...... adequate. The model construction is related to Escardo's metric model for PCF, but here everything is carried out entirely in type theory with guarded recursion, including the formulation of the operational semantics, the model construction and the proof of adequacy...... of coinductive types. In this paper we investigate how type theory with guarded recursion can be used as a metalanguage for denotational semantics useful both for constructing models and for proving properties of these. We do this by constructing a fairly intensional model of PCF and proving it computationally...

  7. A Model of PCF in Guarded Type Theory

    DEFF Research Database (Denmark)

    Paviotti, Marco; Møgelberg, Rasmus Ejlers; Birkedal, Lars

    2015-01-01

    Guarded recursion is a form of recursion where recursive calls are guarded by delay modalities. Previous work has shown how guarded recursion is useful for constructing logics for reasoning about programming languages with advanced features, as well as for constructing and reasoning about element...... adequate. The model construction is related to Escardo's metric model for PCF, but here everything is carried out entirely in type theory with guarded recursion, including the formulation of the operational semantics, the model construction and the proof of adequacy....... of coinductive types. In this paper we investigate how type theory with guarded recursion can be used as a metalanguage for denotational semantics useful both for constructing models and for proving properties of these. We do this by constructing a fairly intensional model of PCF and proving it computationally...

  8. Sorologia da hanseníase utilizando PGL-I: revisão sistemática

    OpenAIRE

    Moura,Rodrigo Scaliante de; Calado,Karla Lucena; Oliveira,Maria Leide W.; Bührer-Sékula,Samira

    2008-01-01

    A sorologia utilizando o antígeno espécie-específico do Mycobacterium leprae, PGL-I, pode ser um marcador de carga bacteriana em pacientes com hanseníase. Estudos identificaram potencial de uso da sorologia na classificação de pacientes para fins de tratamento, monitoramento de terapia, risco de recidiva e na seleção dos contatos com maior risco de adoecer. Foi realizada uma revisão sistemática e 26 artigos foram incluídos na análise comparativa. Avaliamos os resultados do uso da sorologia PG...

  9. Comparative Study on Dispersion and Interfacial Properties of Single Walled Carbon Nanotube/Polymer Composites Using Hansen Solubility Parameters

    DEFF Research Database (Denmark)

    Ma, Jing; Larsen, Mikael

    2013-01-01

    fabricated by solution blending 1 wt % SWNTs with various modification (nonmodified, nitric acid functionalized, and amine functionalized SWNTs) and three kinds of polymeric materials (polycarbonate, polyvinylidene fluoride, and epoxy). Chemical compatibilities between SWNTs and solvents or polymers...... are calculated by the Hansen solubility parameters (HSP) method. The dispersion of the SWNTs in solvents is evaluated by dynamic light scattering. The dispersion of SWNTs in polymers evaluated by a light optical microscope (LOM) generally agrees with the HSP prediction. The strain transfer from the matrix...

  10. Dynamic of exact perturbations in Bianchi IX type cosmological models

    International Nuclear Information System (INIS)

    Mello Neto, J.R.T. de.

    1985-01-01

    The dynamic of Bianchi IX type cosmological models is studied, after reducing Einstein equations to Hamiltonian system. Using the Melnikov method, the existence of chaos in the dynamic of these models is proved, and some numerical experiments are carried out. (M.C.K.) [pt

  11. Models of multiparticle production of the eikonal type

    International Nuclear Information System (INIS)

    Martinis, M.

    1974-01-01

    A survey of eikonal type models for multiparticle production is given. Empirical rules concerning the nature of multiparticle reactions are outlined. A discussion involving kinematics and cross sections for inclusive processes is presented. The constraints of multiparticle unitarity are considered to be of great importance in eikonal models for multiproduction at high energy. (HFdV)

  12. Validation of KENO, ANISN and Hansen-Roach cross-section set on plutonium oxide and metal fuel system

    International Nuclear Information System (INIS)

    Matsumoto, Tadakuni; Yumoto, Ryozo; Nakano, Koh.

    1980-01-01

    In the previous report, the authors discussed the validity of KENO, ANISN and Hansen-Roach 16 group cross-section set on the critical plutonium nitrate solution systems with various geometries, absorbers and neutron interactions. The purpose of the present report is to examine the validity of the same calculation systems on the homogeneous plutonium oxide and plutonium-uranium mixed oxide fuels with various density values. Eleven experiments adopted for validation are summarized. First six experiments were performed at Pacific Northwest Laboratory of Battelle Memorial Institute, and the remaining five at Los Alamos Scientific Laboratory. The characteristics of core fuel are given, and the isotopic composition of plutonium, the relation between H/(Pu + U) atomic ratio and fuel density as compared with the atomic ratios of PuO 2 and mixed oxides in powder storage and pellet fabrication processes, and critical core dimensions and reflector conditions are shown. The effective multiplication factors were calculated with the KENO code. In case of the metal fuels with simple sphere geometry, additional calculations with the ANISN code were performed. The criticality calculation system composed of KENO, ANISN and Hansen-Roach cross-section set was found to be valid for calculating the criticality on plutonium oxide, plutonium-uranium mixed oxide, plutonium metal and uranium metal fuel systems as well as on plutonium solution systems with various geometries, absorbers and neutron interactions. There seems to remain some problems in the method for evaluating experimental correction. Some discussions foloow. (Wakatsuki, Y.)

  13. Atuação do enfermeiro no controle epidemiológico da hanseníase

    Directory of Open Access Journals (Sweden)

    Sara Augusta dos Santos

    1992-09-01

    Full Text Available Analisou-se seníase, na Seção de Dermatologia Sanitária do Hospital Universitário Pedro Ernesto, UERJ. Pretendeu-se alcançar três objetivos entre eles comparar a qualidade do controle epidemiológico dos casos novos de hanseníase em registro ativo de 1986, com os mesmos casos relativos ao período de 1987. Aplicou-se o método descritivo e análise de documentos dos prontuários desses clientes. Utilizou-se um formulário com questões de múltipla escolha e preenchimento de claros, totalizando 27 itens. Constatou-se que o enfermeiro interfere nas variáveis: exames para firmar diagnóstico, exames de contatos e educação para saúde, contribuindo para a melhoria da qualidade assistencial do hanseniano. Conclui-se que há diferença significativa na qualidade do controle epidemiológico da hanseníase entre os grupos constituídos.

  14. Type-2 fuzzy elliptic membership functions for modeling uncertainty

    DEFF Research Database (Denmark)

    Kayacan, Erdal; Sarabakha, Andriy; Coupland, Simon

    2018-01-01

    Whereas type-1 and type-2 membership functions (MFs) are the core of any fuzzy logic system, there are no performance criteria available to evaluate the goodness or correctness of the fuzzy MFs. In this paper, we make extensive analysis in terms of the capability of type-2 elliptic fuzzy MFs...... in modeling uncertainty. Having decoupled parameters for its support and width, elliptic MFs are unique amongst existing type-2 fuzzy MFs. In this investigation, the uncertainty distribution along the elliptic MF support is studied, and a detailed analysis is given to compare and contrast its performance...... advantages mentioned above, elliptic MFs have comparable prediction results when compared to Gaussian and triangular MFs. Finally, in order to test the performance of fuzzy logic controller with elliptic interval type-2 MFs, extensive real-time experiments are conducted for the 3D trajectory tracking problem...

  15. Sequence Domain Harmonic Modeling of Type-IV Wind Turbines

    DEFF Research Database (Denmark)

    Guest, Emerson; Jensen, Kim Høj; Rasmussen, Tonny Wederberg

    2017-01-01

    -sampled pulsewidth modulation and an analysis of converter generated voltage harmonics due to compensated dead-time. The decoupling capabilities of the proposed the SD harmonic model are verified through a power quality (PQ) assessment of a 3MW Type-IV wind turbine. The assessment shows that the magnitude and phase...... of low-order odd converter generated voltage harmonics are dependent on the converter operating point and the phase of the fundamental component of converter current respectively. The SD harmonic model can be used to make PQ assessments of Type-IV wind turbines or incorporated into harmonic load flows...... for computation of PQ in wind power plants....

  16. Model for calculating the boron concentration in PWR type reactors

    International Nuclear Information System (INIS)

    Reis Martins Junior, L.L. dos; Vanni, E.A.

    1986-01-01

    A PWR boron concentration model has been developed for use with RETRAN code. The concentration model calculates the boron mass balance in the primary circuit as the injected boron mixes and is transported through the same circuit. RETRAN control blocks are used to calculate the boron concentration in fluid volumes during steady-state and transient conditions. The boron reactivity worth is obtained from the core concentration and used in RETRAN point kinetics model. A FSAR type analysis of a Steam Line Break Accident in Angra I plant was selected to test the model and the results obtained indicate a sucessfull performance. (Author) [pt

  17. Modeling And Position Control Of Scara Type 3D Printer

    Directory of Open Access Journals (Sweden)

    Ahmet Saygamp305n Ogulmuamp351

    2015-08-01

    Full Text Available In this work a scara robot type 3D printer system is dynamically modeled and position control of the system is realized. For this aim computer aided design model of three degrees of freedom robotic system is created using SolidWorks program then obtained model is exported to MATLABSimMechanics software for position control. Also mathematical model of servo motors used in robotic 3D printer system is included in control methodology to design proportional controllers. Uncontrolled and controlled position results are simulated and given in the form of the graphics.

  18. Vivências compartilhadas de filhos separados pela hanseníase no RN a luz da história oral de vida

    OpenAIRE

    Cabral, Ana Michele de Farias

    2013-01-01

    Várias epidemias marcaram a vida das pessoas e coletividades, em todos os períodos históricos, sendo um dos principais exemplos a hanseníase, doença infecto-contagiosa, marcada pelo estigma, preconceito e exclusão social. No passado, o isolamento compulsório dos pacientes portadores de hanseníase causou sérios problemas sociais e psicológicos, resultando no afastamento e na ruptura total ou parcial do vínculo familiar. Os filhos privados desse convívio, retirados muitas vezes de forma desuman...

  19. Polarisation Spectral Synthesis For Type Ia Supernova Explosion Models

    Science.gov (United States)

    Bulla, Mattia

    2017-02-01

    Despite their relevance across a broad range of astrophysical research topics, Type Ia supernova explosions are still poorly understood and answers to the questions of when, why and how these events are triggered remain unclear. In this respect, polarisation offers a unique opportunity to discriminate between the variety of possible scenarios. The observational evidence that Type Ia supernovae are associated with rather low polarisation signals (smaller than a few per cent) places strong constraints for models and calls for modest asphericities in the progenitor system and/or explosion mechanism.The goal of this thesis is to assess the validity of contemporary Type Ia supernova explosion models by testing whether their predicted polarisation signatures can account for the small signals usually observed. To this end, we have implemented and tested an innovative Monte Carlo scheme in the radiative transfer code artis. Compared to previous Monte Carlo approaches, this technique produces synthetic observables (light curves, flux and polarisation spectra) with a substantial reduction in the Monte Carlo noise and therefore in the required computing time. This improvement is particularly crucial for our study as we aim to extract very weak polarisation signals, comparable to those detected in Type Ia supernovae. We have also demonstrated the applicability of this method to other classes of supernovae via a preliminary study of the first spectropolarimetry observations of superluminous supernovae.Using this scheme, we have calculated synthetic spectropolarimetry for three multi-dimensional explosion models recently proposed as promising candidates to explain Type Ia supernovae. Our findings highlight the power of spectropolarimetry in testing and discriminating between different scenarios. While all the three models predict light curves and flux spectra that are similar to each others and reproduce those observed in Type Ia supernovae comparably well, polarisation does

  20. Annihilation Prediction for Lanchester-Type Models of Modern Warfare

    OpenAIRE

    Brown, G.G.; Taylor, J.

    1983-01-01

    Operations Research, 31, p.752. This paper introduces important new functions for analytic solution of Launch-ester-type equations of modern warfare for combat between two homogeneous forces modeled by power attrtition-rate coefficients with "no offset". Tabulations of these Lanchester-Clifford-Schlatii (or LCS) functions allow one to study this particular variable-coefficient model almost as easily and thoroughly as Lanchester's classic constant-coefficient one. LCS functions allow one ...

  1. Inhomogeneous generalizations of Bianchi type VIh models with perfect fluid

    Science.gov (United States)

    Roy, S. R.; Prasad, A.

    1991-07-01

    Inhomogeneous universes admitting an Abelian G2 of isometry and filled with perfect fluid have been derived. These contain as special cases exact homogeneous universes of Bianchi type VIh. Many of these universes asymptotically tend to homogeneous Bianchi VIh universes. The models have been discussed for their physical and kinematical behaviors.

  2. Lattice simulation of 2d Gross-Neveu-type models

    International Nuclear Information System (INIS)

    Limmer, M.; Gattringer, C.; Hermann, V.

    2006-01-01

    Full text: We discuss a Monte Carlo simulation of 2d Gross-Neveu-type models on the lattice. The four-Fermi interaction is written as a Gaussian integral with an auxiliary field and the fermion determinant is included by reweighting. We present results for bulk quantities and correlators and compare them to a simulation using a fermion-loop representation. (author)

  3. Type-2 fuzzy graphical models for pattern recognition

    CERN Document Server

    Zeng, Jia

    2015-01-01

    This book discusses how to combine type-2 fuzzy sets and graphical models to solve a range of real-world pattern recognition problems such as speech recognition, handwritten Chinese character recognition, topic modeling as well as human action recognition. It covers these recent developments while also providing a comprehensive introduction to the fields of type-2 fuzzy sets and graphical models. Though primarily intended for graduate students, researchers and practitioners in fuzzy logic and pattern recognition, the book can also serve as a valuable reference work for researchers without any previous knowledge of these fields. Dr. Jia Zeng is a Professor at the School of Computer Science and Technology, Soochow University, China. Dr. Zhi-Qiang Liu is a Professor at the School of Creative Media, City University of Hong Kong, China.

  4. [Discussion of Chinese syndrome typing in acute hepatic failure model].

    Science.gov (United States)

    Zhang, Jin-liang; Zeng, Hui; Wang, Xian-bo

    2011-05-01

    To study Chinese syndrome typing of acute hepatic failure (AHF) mice model by screening effective formulae. Lipoplysaccharides (LPS)/D-galactosamine (D-GaIN) was intraperitoneally injected to mice to establish the AHF mice model. Yinchenhao Decoction, Huanglian Jiedu Decoction, Buzhong Yiqi Decoction, and Xijiao Dihuang Decoction were administered to model mice respectively by gastrogavage. The behavior and the survival rate were monitored. The liver function and pathological changes of liver tissues were detected. In all the tested classic recipes, the survival rate was elevated from 10% to 60% by administration of Xijiao Dihuang Decoction. Five h after modeling, the serum alanine aminotransferase (ALT) level was (183.95 +/- 52.00) U/L, and aspartate aminotransferase (AST) (235.70 +/- 34.03) U/L in Xijiao Di-huang Decoction Group, lower than those of the model control group, but with insignificant difference (ALT: 213.32 +/- 71.93 U/L; AST: 299.48 +/- 70.56 U/L, both P > 0.05). Xijiao Dihuang Decoction could obviously alleviate the liver injury. Xijiao Dihuang Decoction was an effective formula for LPS/D-GaIN induced AHF model. According to syndrome typing through formula effect, heat toxin and blood stasis syndrome dominated in the LPS/D-GalN induced AHF mice model.

  5. Pure neural leprosy: steroids prevent neuropathy progression Corticosteróides previnem a neuropatia na hanseníase

    Directory of Open Access Journals (Sweden)

    Márcia R. Jardim

    2007-12-01

    Full Text Available Multidrug therapy (MDT, with rifampicin, dapsone, and clofazimine, treats leprosy infection but is insufficient in arresting or preventing the nerve damage that causes impairments and disabilities. This case-series study evaluates the benefits of the combined use of steroids and MDT in preventing nerve damage in patients with pure neural leprosy (PNL. In addition to MDT, 24 patients (88% male aged 20-79 years, median=41 received a daily morning dose of 60 mg prednisone (PDN that was gradually reduced by 10 mg during each of the following 5 months. PNL was clinically diagnosed and confirmed by nerve histopathology or PCR. A low prevalence (8.3% of reaction was observed after release from treatment. However, most of the clinical parameters showed significant improvement; and a reduction of nerve conduction block was observed in 42% of the patients. The administration of full-dose PDN improved the clinical and electrophysiological condition of the PNL patients, contributing to the prevention of further neurological damage.A poliquimioterapia (PQT, com rifampicina, dapsona, e clofazimina, trata a infecção na hanseníase, mas é insuficiente para interromper ou prevenir o comprometimento neurológico que causa as incapacidades e desabilidades, nesta enfermidade. Este estudo de série de casos avalia o benefício do uso combinado de prednisona e PQT na prevenção do dano neurológico em pacientes com a forma neural pura da hanseníase (FNP. Além do PQT, 24 pacientes (88% homens, com idade variando entre 20-79, mediana=41 receberam uma dose diária de 60 mg prednisona que foi reduzida gradualmente na dose de 10 mg durante cada um dos 5 meses subseqüentes. FNP foi diagnosticada clinicamente e confirmada através do estudo histopatológico ou PCR. Baixa prevalência de reação (8,3% foi observada apenas após o final do tratamento. A maioria dos parâmetros clínicos mostrou melhora significativa e redução do bloqueio de condução foi observada

  6. A Budyko-type Model for Human Water Consumption

    Science.gov (United States)

    Lei, X.; Zhao, J.; Wang, D.; Sivapalan, M.

    2017-12-01

    With the expansion of human water footprint, water crisis is no longer only a conflict or competition for water between different economic sectors, but also increasingly between human and the environment. In order to describe the emergent dynamics and patterns of the interaction, a theoretical framework that encapsulates the physical and societal controls impacting human water consumption is needed. In traditional hydrology, Budyko-type models are simple but efficient descriptions of vegetation-mediated hydrologic cycle in catchments, i.e., the partitioning of mean annual precipitation into runoff and evapotranspiration. Plant water consumption plays a crucial role in the process. Hypothesized similarities between human-water and vegetation-water interactions, including water demand, constraints and system functioning, give the idea of corresponding Budyko-type framework for human water consumption at the catchment scale. Analogous to variables of Budyko-type models for hydrologic cycle, water demand, water consumption, environmental water use and available water are corresponding to potential evaporation, actual evaporation, runoff and precipitation respectively. Human water consumption data, economic and hydro-meteorological data for 51 human-impacted catchments and 10 major river basins in China are assembled to look for the existence of a Budyko-type relationship for human water consumption, and to seek explanations for the spread in the observed relationship. Guided by this, a Budyko-type analytical model is derived based on application of an optimality principle, that of maximum water benefit. The model derived has the same functional form and mathematical features as those that apply for the original Budyko model. Parameters of the new Budyko-type model for human consumption are linked to economic and social factors. The results of this paper suggest that the functioning of both social and hydrologic subsystems within catchment systems can be explored within

  7. Desigualdade social, crescimento urbano e hanseníase em Manaus: abordagem espacial Desigualdad social, crecimiento urbano y hanseníasis en Manaus (Norte de Brasil: abordaje espacial Social inequality, urban growth and leprosy in Manaus: a spatial approach

    Directory of Open Access Journals (Sweden)

    Elsia Nascimento Belo Imbiriba

    2009-08-01

    Full Text Available OBJETIVO: Analisar a epidemiologia de hanseníase segundo a distribuição espacial e condições de vida da população. MÉTODOS: Estudo ecológico baseado na espacialização da hanseníase em Manaus (AM, entre 1998 e 2004. Os 4.104 casos obtidos do Sistema de Informações de Agravos de Notificação foram georreferenciados de acordo com a localização dos endereços em 1.536 setores censitários urbanos, por meio de quatro técnicas: correios (73,7% dos endereços encontrados; Programa de Cadastro de Logradouros (7,3%; Programa Saúde da Família (2,1% e folhas de coleta do Instituto Brasileiro de Geografia e Estatística (1,5%. Para cálculo do coeficiente de detecção utilizou a população de 2001. Na análise espacial foi aplicado o método bayesiano empírico local para produzir uma estimativa do risco da hanseníase, suavizando o efeito da flutuação das taxas, quando calculadas para pequenas áreas. Para análise da associação entre espacialização e fatores de risco empregou-se a regressão logística, tendo como variáveis explicativas a ocorrência de casos em menores de 15 anos (indicador de gravidade e o Índice de Carência Social construído a partir das variáveis do Censo 2000. RESULTADOS: O coeficiente de detecção apresentou-se hiperendêmico em 34,0% dos setores e muito alto em 26,7%. A medida de associação (odds ratio referente às variáveis explicativas foi significativa. A combinação de baixa condição de vida e ocorrência em menores de 15 anos foi adotada para identificar as áreas prioritárias para intervenção. CONCLUSÕES: A análise espacial da hanseníase mostrou que a distribuição da doença é heterogênea, atingindo mais intensamente as regiões habitadas por grupos em situação de maior vulnerabilidade.OBJETIVO: Analizar la epidemiología de hanseníasis según la distribución espacial y condiciones de vida de la población. MÉTODOS: Estudio ecológico basado en la especialización de la

  8. Dosha brain-types: A neural model of individual differences.

    Science.gov (United States)

    Travis, Frederick T; Wallace, Robert Keith

    2015-01-01

    This paper explores brain patterns associated with the three categories of regulatory principles of the body, mind, and behavior in Ayurveda, called Vata, Pitta, and Kapha dosha. A growing body of research has reported patterns of blood chemistry, genetic expression, physiological states, and chronic diseases associated with each dosha type. Since metabolic and growth factors are controlled by the nervous system, each dosha type should be associated with patterns of functioning of six major areas of the nervous system: The prefrontal cortex, the reticular activating system, the autonomic nervous system, the enteric nervous system, the limbic system, and the hypothalamus. For instance, the prefrontal cortex, which includes the anterior cingulate, ventral medial, and the dorsal lateral cortices, would exhibit a high range of functioning in the Vata brain-type leading to the possibility of being easily overstimulated. The Vata brain-type performs activity quickly. Learns quickly and forgets quickly. Their fast mind gives them an edge in creative problem solving. The Pitta brain-type reacts strongly to all challenges leading to purposeful and resolute actions. They never give up and are very dynamic and goal oriented. The Kapha brain-type is slow and steady leading to methodical thinking and action. They prefer routine and needs stimulation to get going. A model of dosha brain-types could provide a physiological foundation to understand individual differences. This model could help individualize treatment modalities to address different mental and physical dysfunctions. It also could explain differences in behavior seen in clinical as well as in normal populations.

  9. Dosha brain-types: A neural model of individual differences

    Directory of Open Access Journals (Sweden)

    Frederick T Travis

    2015-01-01

    Full Text Available This paper explores brain patterns associated with the three categories of regulatory principles of the body, mind, and behavior in Ayurveda, called Vata, Pitta, and Kapha dosha. A growing body of research has reported patterns of blood chemistry, genetic expression, physiological states, and chronic diseases associated with each dosha type. Since metabolic and growth factors are controlled by the nervous system, each dosha type should be associated with patterns of functioning of six major areas of the nervous system: The prefrontal cortex, the reticular activating system, the autonomic nervous system, the enteric nervous system, the limbic system, and the hypothalamus. For instance, the prefrontal cortex, which includes the anterior cingulate, ventral medial, and the dorsal lateral cortices, would exhibit a high range of functioning in the Vata brain-type leading to the possibility of being easily overstimulated. The Vata brain-type performs activity quickly. Learns quickly and forgets quickly. Their fast mind gives them an edge in creative problem solving. The Pitta brain-type reacts strongly to all challenges leading to purposeful and resolute actions. They never give up and are very dynamic and goal oriented. The Kapha brain-type is slow and steady leading to methodical thinking and action. They prefer routine and needs stimulation to get going. A model of dosha brain-types could provide a physiological foundation to understand individual differences. This model could help individualize treatment modalities to address different mental and physical dysfunctions. It also could explain differences in behavior seen in clinical as well as in normal populations.

  10. Ports: Definition and study of types, sizes and business models

    OpenAIRE

    Ivan Roa; Yessica Peña; Beatriz Amante; María Goretti

    2013-01-01

    Purpose: In the world today there are thousands of port facilities of different types and sizes, competing to capture some market share of freight by sea, mainly. This article aims to determine the type of port and the most common size, in order to find out which business model is applied in that segment and what is the legal status of the companies of such infrastructure.Design/methodology/approach: To achieve this goal, we develop a research on a representative sample of 800 ports worldwide...

  11. PULSATING REVERSE DETONATION MODELS OF TYPE Ia SUPERNOVAE. II. EXPLOSION

    International Nuclear Information System (INIS)

    Bravo, Eduardo; Garcia-Senz, Domingo; Cabezon, Ruben M.; DomInguez, Inmaculada

    2009-01-01

    Observational evidences point to a common explosion mechanism of Type Ia supernovae based on a delayed detonation of a white dwarf (WD). However, all attempts to find a convincing ignition mechanism based on a delayed detonation in a destabilized, expanding, white dwarf have been elusive so far. One of the possibilities that has been invoked is that an inefficient deflagration leads to pulsation of a Chandrasekhar-mass WD, followed by formation of an accretion shock that confines a carbon-oxygen rich core, while transforming the kinetic energy of the collapsing halo into thermal energy of the core, until an inward moving detonation is formed. This chain of events has been termed Pulsating Reverse Detonation (PRD). In this work, we present three-dimensional numerical simulations of PRD models from the time of detonation initiation up to homologous expansion. Different models characterized by the amount of mass burned during the deflagration phase, M defl , give explosions spanning a range of kinetic energies, K ∼ (1.0-1.2) x 10 51 erg, and 56 Ni masses, M( 56 Ni) ∼ 0.6-0.8 M sun , which are compatible with what is expected for typical Type Ia supernovae. Spectra and light curves of angle-averaged spherically symmetric versions of the PRD models are discussed. Type Ia supernova spectra pose the most stringent requirements on PRD models.

  12. Historial oral y memoria de los enfermos de Hansen en dos lazaretos de Colombia: trayectorias de vida, conflictos y resistencias

    Directory of Open Access Journals (Sweden)

    Natalia Botero-Jaramillo

    Full Text Available Resumen Investiga la historia oral de la enfermedad de Hansen en dos comunidades de Colombia que fueron hasta 1961 lazaretos. La historia oral en torno de la enfermedad ha permitido conjugar la memoria individual con la memoria colectiva. Esta historia ha quedado en la oralidad y pocos trabajos académicos la han recopilado. Utilizamos la historia oral como método de investigación cualitativo, para analizar cómo enfermos y convivientes se posicionan ante la enfermedad y cómo atraviesa toda su existencia, resignificando los conceptos de salud y enfermedad, de normalidad y anormalidad, y cómo en sus trayectorias de vida emprendieron estrategias de resistencia que les permitiera aproximarse a la normalidad, desde sus propias significaciones socioculturales.

  13. Oral history and memories of Hansen's disease patients in two Colombian leper colonies: life trajectories, conflicts and resistance strategies.

    Science.gov (United States)

    Botero-Jaramillo, Natalia; Mora-Blanco, Jessica; Quesada-Jiménez, Nelson Daniel

    2017-01-01

    The paper examines the oral history of Hansen's disease in two Colombian communities that were leper colonies until 1961. The oral history around the disease allows us to connect individuals' memories with collective memory. This history remains an oral one, and few academic studies have documented it. We use oral history as a qualitative research method in order to analyze how the patients and those who lived alongside them positioned themselves in terms of the disease and how it permeated their entire existence, re-signifying the concepts of health and disease, normality and abnormality. We examine how, over the course of their lives, they engaged in resistance strategies that allowed them to get closer to normality, in their own sociocultural terms.

  14. Impaired peripheral nerve regeneration in type-2 diabetic mouse model.

    Science.gov (United States)

    Pham, Vuong M; Tu, Nguyen Huu; Katano, Tayo; Matsumura, Shinji; Saito, Akira; Yamada, Akihiro; Furue, Hidemasa; Ito, Seiji

    2018-01-01

    Peripheral neuropathy is one of the most common and serious complications of type-2 diabetes. Diabetic neuropathy is characterized by a distal symmetrical sensorimotor polyneuropathy, and its incidence increases in patients 40 years of age or older. In spite of extensive research over decades, there are few effective treatments for diabetic neuropathy besides glucose control and improved lifestyle. The earliest changes in diabetic neuropathy occur in sensory nerve fibers, with initial degeneration and regeneration resulting in pain. To seek its effective treatment, here we prepared a type-2 diabetic mouse model by giving mice 2 injections of streptozotocin and nicotinamide and examining the ability for nerve regeneration by using a sciatic nerve transection-regeneration model previously established by us. Seventeen weeks after the last injection, the mice exhibited symptoms of type-2 diabetes, that is, impaired glucose tolerance, decreased insulin level, mechanical hyperalgesia, and impaired sensory nerve fibers in the plantar skin. These mice showed delayed functional recovery and nerve regeneration by 2 weeks compared with young healthy mice and by 1 week compared with age-matched non-diabetic mice after axotomy. Furthermore, type-2 diabetic mice displayed increased expression of PTEN in their DRG neurons. Administration of a PTEN inhibitor at the cutting site of the nerve for 4 weeks promoted the axonal transport and functional recovery remarkably. This study demonstrates that peripheral nerve regeneration was impaired in type-2 diabetic model and that its combination with sciatic nerve transection is suitable for the study of the pathogenesis and treatment of early diabetic neuropathy. © 2017 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  15. Identification of reverse logistics decision types from mathematical models

    Directory of Open Access Journals (Sweden)

    Pascual Cortés Pellicer

    2018-04-01

    Full Text Available Purpose: The increase in social awareness, politics and environmental regulation, the scarcity of raw materials and the desired “green” image, are some of the reasons that lead companies to decide for implement processes of Reverse Logistics (RL. At the time when incorporate new RL processes as key business processes, new and important decisions need to be made. Identification and knowledge of these decisions, including the information available and the implications for the company or supply chain, will be fundamental for decision-makers to achieve the best results. In the present work, the main types of RL decisions are identified. Design/methodology/approach: This paper is based on the analysis of mathematical models designed as tools to aid decision making in the field of RL. Once the types of interest work to be analyzed are defined, those studies that really deal about the object of study are searched and analyzed. The decision variables that are taken at work are identified and grouped according to the type of decision and, finally, are showed the main types of decisions used in mathematical models developed in the field of RL.     Findings: The principal conclusion of the research is that the most commonly addressed decisions with mathematical models in the field of RL are those related to the network’s configuration, followed by tactical/operative decisions such as the selections of product’s treatments to realize and the policy of returns or prices, among other decisions. Originality/value: The identification of the main decisions types of the reverse logistics will allow the managers of these processes to know and understand them better, while offer an integrated vision of them, favoring the achievement of better results.

  16. Generic Business Model Types for Enterprise Mashup Intermediaries

    Science.gov (United States)

    Hoyer, Volker; Stanoevska-Slabeva, Katarina

    The huge demand for situational and ad-hoc applications desired by the mass of business end users led to a new kind of Web applications, well-known as Enterprise Mashups. Users with no or limited programming skills are empowered to leverage in a collaborative manner existing Mashup components by combining and reusing company internal and external resources within minutes to new value added applications. Thereby, Enterprise Mashup environments interact as intermediaries to match the supply of providers and demand of consumers. By following the design science approach, we propose an interaction phase model artefact based on market transaction phases to structure required intermediary features. By means of five case studies, we demonstrate the application of the designed model and identify three generic business model types for Enterprise Mashups intermediaries (directory, broker, and marketplace). So far, intermediaries following a real marketplace business model don’t exist in context of Enterprise Mashups and require further research for this emerging paradigm.

  17. Models for Type Ia Supernovae and Related Astrophysical Transients

    Science.gov (United States)

    Röpke, Friedrich K.; Sim, Stuart A.

    2018-06-01

    We give an overview of recent efforts to model Type Ia supernovae and related astrophysical transients resulting from thermonuclear explosions in white dwarfs. In particular we point out the challenges resulting from the multi-physics multi-scale nature of the problem and discuss possible numerical approaches to meet them in hydrodynamical explosion simulations and radiative transfer modeling. We give examples of how these methods are applied to several explosion scenarios that have been proposed to explain distinct subsets or, in some cases, the majority of the observed events. In case we comment on some of the successes and shortcoming of these scenarios and highlight important outstanding issues.

  18. A preon model with hidden electric and magnetic type charges

    International Nuclear Information System (INIS)

    Pati, J.C.; Strathdee, J.

    1980-11-01

    The U(1) x U(1) binding forces in an earlier preonic composite model of quarks and leptons are interpreted as arising from hidden electric and magnetic type charges. The preons may possess intrinsic spin zero; the half-integer spins of the composites being contributed by the force field. The quark-lepton gauge symmetry is interpreted as an effective low-energy symmetry arising at the composite level. Some remarks are made regarding the possible composite nature of the graviton. (author)

  19. Ports: Definition and study of types, sizes and business models

    Directory of Open Access Journals (Sweden)

    Ivan Roa

    2013-09-01

    Full Text Available Purpose: In the world today there are thousands of port facilities of different types and sizes, competing to capture some market share of freight by sea, mainly. This article aims to determine the type of port and the most common size, in order to find out which business model is applied in that segment and what is the legal status of the companies of such infrastructure.Design/methodology/approach: To achieve this goal, we develop a research on a representative sample of 800 ports worldwide, which manage 90% of the containerized port loading. Then you can find out the legal status of the companies that manage them.Findings: The results indicate a port type and a dominant size, which are mostly managed by companies subject to a concession model.Research limitations/implications: In this research, we study only those ports that handle freight (basically containerized, ignoring other activities such as fishing, military, tourism or recreational.Originality/value: This is an investigation to show that the vast majority of the studied segment port facilities are governed by a similar corporate model and subject to pressure from the markets, which increasingly demand efficiency and service. Consequently, we tend to concession terminals to private operators in a process that might be called privatization, but in the strictest sense of the term, is not entirely realistic because the ownership of the land never ceases to be public

  20. Impact of model structure and parameterization on Penman-Monteith type evaporation models

    KAUST Repository

    Ershadi, A.; McCabe, Matthew; Evans, J.P.; Wood, E.F.

    2015-01-01

    Overall, the results illustrate the sensitivity of Penman-Monteith type models to model structure, parameterization choice and biome type. A particular challenge in flux estimation relates to developing robust and broadly applicable model formulations. With many choices available for use, providing guidance on the most appropriate scheme to employ is required to advance approaches for routine global scale flux estimates, undertake hydrometeorological assessments or develop hydrological forecasting tools, amongst many other applications. In such cases, a multi-model ensemble or biome-specific tiled evaporation product may be an appropriate solution, given the inherent variability in model and parameterization choice that is observed within single product estimates.

  1. Modeling Types of Pedal Applications Using a Driving Simulator.

    Science.gov (United States)

    Wu, Yuqing; Boyle, Linda Ng; McGehee, Daniel; Roe, Cheryl A; Ebe, Kazutoshi; Foley, James

    2015-11-01

    The aim of this study was to examine variations in drivers' foot behavior and identify factors associated with pedal misapplications. Few studies have focused on the foot behavior while in the vehicle and the mishaps that a driver can encounter during a potentially hazardous situation. A driving simulation study was used to understand how drivers move their right foot toward the pedals. The study included data from 43 drivers as they responded to a series of rapid traffic signal phase changes. Pedal application types were classified as (a) direct hit, (b) hesitated, (c) corrected trajectory, and (d) pedal errors (incorrect trajectories, misses, slips, or pressed both pedals). A mixed-effects multinomial logit model was used to predict the likelihood of one of these pedal applications, and linear mixed models with repeated measures were used to examine the response time and pedal duration given the various experimental conditions (stimuli color and location). Younger drivers had higher probabilities of direct hits when compared to other age groups. Participants tended to have more pedal errors when responding to a red signal or when the signal appeared to be closer. Traffic signal phases and locations were associated with pedal response time and duration. The response time and pedal duration affected the likelihood of being in one of the four pedal application types. Findings from this study suggest that age-related and situational factors may play a role in pedal errors, and the stimuli locations could affect the type of pedal application. © 2015, Human Factors and Ergonomics Society.

  2. Spectral action for Bianchi type-IX cosmological models

    International Nuclear Information System (INIS)

    Fan, Wentao; Fathizadeh, Farzad; Marcolli, Matilde

    2015-01-01

    A rationality result previously proved for Robertson-Walker metrics is extended to a homogeneous anisotropic cosmological model, namely the Bianchi type-IX minisuperspace. It is shown that the Seeley-de Witt coefficients appearing in the expansion of the spectral action for the Bianchi type-IX geometry are expressed in terms of polynomials with rational coefficients in the cosmic evolution factors w_1(t),w_2(t),w_3(t), and their higher derivates with respect to time. We begin with the computation of the Dirac operator of this geometry and calculate the coefficients a_0,a_2,a_4 of the spectral action by using heat kernel methods and parametric pseudodifferential calculus. An efficient method is devised for computing the Seeley-de Witt coefficients of a geometry by making use of Wodzicki’s noncommutative residue, and it is confirmed that the method checks out for the cosmological model studied in this article. The advantages of the new method are discussed, which combined with symmetries of the Bianchi type-IX metric, yield an elegant proof of the rationality result.

  3. Spectral action for Bianchi type-IX cosmological models

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Wentao; Fathizadeh, Farzad; Marcolli, Matilde [Division of Physics, Mathematics and Astronomy, California Institute of Technology,1200 E. California Blvd., Pasadena, CA 91125 (United States)

    2015-10-13

    A rationality result previously proved for Robertson-Walker metrics is extended to a homogeneous anisotropic cosmological model, namely the Bianchi type-IX minisuperspace. It is shown that the Seeley-de Witt coefficients appearing in the expansion of the spectral action for the Bianchi type-IX geometry are expressed in terms of polynomials with rational coefficients in the cosmic evolution factors w{sub 1}(t),w{sub 2}(t),w{sub 3}(t), and their higher derivates with respect to time. We begin with the computation of the Dirac operator of this geometry and calculate the coefficients a{sub 0},a{sub 2},a{sub 4} of the spectral action by using heat kernel methods and parametric pseudodifferential calculus. An efficient method is devised for computing the Seeley-de Witt coefficients of a geometry by making use of Wodzicki’s noncommutative residue, and it is confirmed that the method checks out for the cosmological model studied in this article. The advantages of the new method are discussed, which combined with symmetries of the Bianchi type-IX metric, yield an elegant proof of the rationality result.

  4. Modelling of Performance of Caisson Type Breakwaters under Extreme Waves

    Science.gov (United States)

    Güney Doǧan, Gözde; Özyurt Tarakcıoǧlu, Gülizar; Baykal, Cüneyt

    2016-04-01

    Many coastal structures are designed without considering loads of tsunami-like waves or long waves although they are constructed in areas prone to encounter these waves. Performance of caisson type breakwaters under extreme swells is tested in Middle East Technical University (METU) Coastal and Ocean Engineering Laboratory. This paper presents the comparison of pressure measurements taken along the surface of caisson type breakwaters and obtained from numerical modelling of them using IH2VOF as well as damage behavior of the breakwater under the same extreme swells tested in a wave flume at METU. Experiments are conducted in the 1.5 m wide wave flume, which is divided into two parallel sections (0.74 m wide each). A piston type of wave maker is used to generate the long wave conditions located at one end of the wave basin. Water depth is determined as 0.4m and kept constant during the experiments. A caisson type breakwater is constructed to one side of the divided flume. The model scale, based on the Froude similitude law, is chosen as 1:50. 7 different wave conditions are applied in the tests as the wave period ranging from 14.6 s to 34.7 s, wave heights from 3.5 m to 7.5 m and steepness from 0.002 to 0.015 in prototype scale. The design wave parameters for the breakwater were 5m wave height and 9.5s wave period in prototype. To determine the damage of the breakwater which were designed according to this wave but tested under swell waves, video and photo analysis as well as breakwater profile measurements before and after each test are performed. Further investigations are carried out about the acting wave forces on the concrete blocks of the caisson structures via pressure measurements on the surfaces of these structures where the structures are fixed to the channel bottom minimizing. Finally, these pressure measurements will be compared with the results obtained from the numerical study using IH2VOF which is one of the RANS models that can be applied to simulate

  5. ANTI-CIUDAD COMO INFRAESTRUCTURA. EL SISTEMA LINEAL CONTINUO DE OSKAR HANSEN / Anti-city as infrastructure. Oskar Hansen’s Linear Continuous System

    Directory of Open Access Journals (Sweden)

    Marta López-Marcos

    2015-11-01

    the proliferation of large-scale land planning and urban planning projects with a view to not only improving the quality of life of their inhabitants, but also strengthening their position on the continent and worldwide. This paper focusses particularly on the case of the People’s Republic of Poland, where such issues were tackled profusely from a number of angles. As a specific example, the idea by architect Oskar Hansen of a Linear Continuous System combines the socialist vision of the State as a producer of space with the concept of individual participation within a group – following his Theory on Open Form and his connections with Team X – based on an architectural substrate: the model of an “anti-city”, which gave rise to issues that remain relevant to this day.

  6. Three-dimensional Modeling of Type Ia Supernova Explosions

    Science.gov (United States)

    Khokhlov, Alexei

    2001-06-01

    A deflagration explosion of a Type Ia Supernova (SNIa) is studied using three-dimensional, high-resolution, adaptive mesh refinement fluid dynamic calculations. Deflagration speed in an exploding Chandrasekhar-mass carbon-oxygen white dwarf (WD) grows exponentially, reaches approximately 30the speed of sound, and then declines due to a WD expansion. Outermost layers of the WD remain unburned. The explosion energy is comparable to that of a Type Ia supernova. The freezing of turbulent motions by expansion appears to be a crucial physical mechanism regulating the strength of a supernova explosion. In contrast to one-dimensional models, three-dimensional calculations predict the formation of Si-group elements and pockets of unburned CO in the middle and in central regions of a supernova ejecta. This, and the presence of unburned outer layer of carbon-oxygen may pose problems for SNIa spectra. Explosion sensitivity to initial conditions and its relation to a diversity of SNIa is discussed.

  7. Future of Plant Functional Types in Terrestrial Biosphere Models

    Science.gov (United States)

    Wullschleger, S. D.; Euskirchen, E. S.; Iversen, C. M.; Rogers, A.; Serbin, S.

    2015-12-01

    Earth system models describe the physical, chemical, and biological processes that govern our global climate. While it is difficult to single out one component as being more important than another in these sophisticated models, terrestrial vegetation is a critical player in the biogeochemical and biophysical dynamics of the Earth system. There is much debate, however, as to how plant diversity and function should be represented in these models. Plant functional types (PFTs) have been adopted by modelers to represent broad groupings of plant species that share similar characteristics (e.g. growth form) and roles (e.g. photosynthetic pathway) in ecosystem function. In this review the PFT concept is traced from its origin in the early 1800s to its current use in regional and global dynamic vegetation models (DVMs). Special attention is given to the representation and parameterization of PFTs and to validation and benchmarking of predicted patterns of vegetation distribution in high-latitude ecosystems. These ecosystems are sensitive to changing climate and thus provide a useful test case for model-based simulations of past, current, and future distribution of vegetation. Models that incorporate the PFT concept predict many of the emerging patterns of vegetation change in tundra and boreal forests, given known processes of tree mortality, treeline migration, and shrub expansion. However, representation of above- and especially belowground traits for specific PFTs continues to be problematic. Potential solutions include developing trait databases and replacing fixed parameters for PFTs with formulations based on trait co-variance and empirical trait-environment relationships. Surprisingly, despite being important to land-atmosphere interactions of carbon, water, and energy, PFTs such as moss and lichen are largely absent from DVMs. Close collaboration among those involved in modelling with the disciplines of taxonomy, biogeography, ecology, and remote sensing will be

  8. Model air-supported drum-type homopolar generator

    International Nuclear Information System (INIS)

    Kustom, R.L.; Fuja, R.E.; Wehrle, R.B.; Smith, R.P.; Kovarik, T.J.

    1977-01-01

    A single cylinder, drum-type homopolar generator has been designed and built for the purpose of developing a simple air support system for thin cylinder rotors operated at high surface velocities and significant radial drum growth. The model has an aluminum cylinder which is 0.32 cm thick, 25 cm in diameter, and 12.7 cm long. It is designed to operate at a peak current of 2500 A and to store a total of 40 kJ with a surface velocity of 305 m/sec

  9. A MATHEMATICAL MODEL OF CHP 2000 TYPE PROGRESSIVE GEAR

    Directory of Open Access Journals (Sweden)

    Paweł Lonkwic

    2016-12-01

    Full Text Available The project of CHP2000 type progressive gear has been presented in the article. The offered solution from its construction point of view differs from the existing solutions due to the application of Belleville springs packets supporting the braking roller cam and achieving a flexible range of the gear loading. The standard concept of the gear loading within a mathematical and a geometrical model has been presented in the article. The proposed solution can be used in the friction lifts with the loading capacity from 8500 up to 20000 N.

  10. A new Preisach-type vector model of hysteresis

    Energy Technology Data Exchange (ETDEWEB)

    D' Aquino, M. E-mail: mdaquino@unina.it; Serpico, C. E-mail: serpico@unina.it

    2004-05-01

    A new class of scalar hysteresis operators is obtained from the classical Preisach scalar model of hysteresis by introducing a transformation of variables dependent on a suitable function g. The operators of this class are defined by means of a new type of Play operator and are characterized by the property of having the same scalar input-output relationship. These operators are then extended to the isotropic vector case by using the vector extension of the scalar Play operator. It is shown that the function g, although does not affect the scalar behavior, it does affect the vector behaviour of the mathematical model. The influence of the function g is illustrated by reporting numerically computed rotational hysteresis losses curves for different choices of the function g.

  11. Modeling and analysis on ring-type piezoelectric transformers.

    Science.gov (United States)

    Ho, Shine-Tzong

    2007-11-01

    This paper presents an electromechanical model for a ring-type piezoelectric transformer (PT). To establish this model, vibration characteristics of the piezoelectric ring with free boundary conditions are analyzed in advance. Based on the vibration analysis of the piezoelectric ring, the operating frequency and vibration mode of the PT are chosen. Then, electromechanical equations of motion for the PT are derived based on Hamilton's principle, which can be used to simulate the coupled electromechanical system for the transformer. Such as voltage stepup ratio, input impedance, output impedance, input power, output power, and efficiency are calculated by the equations. The optimal load resistance and the maximum efficiency for the PT will be presented in this paper. Experiments also were conducted to verify the theoretical analysis, and a good agreement was obtained.

  12. Evolutionary models of early-type contact binary SV Centauri

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Y; Saio, H [Tohoku Univ., Sendai (Japan). Faculty of Science; Sugimoto, Daiichiro

    1978-12-01

    Models of the early-type contact binary system SV Centauri are computed with a binary-star evolution program. The effects of mass exchange, i.e., the effects of mass acceptance as well as mass loss, are properly included. With the initial masses of the component stars as 12.4 and 8.0 M sub(solar mass), the following observed configurations are well reproduced; the component stars are definitely in contact and the rate of mass exchange is 4 x 10/sup -4/ M sub(solar mass)yr/sup -1/. The more massive component is less luminous and has a lower effective temperature. Such features are also reproduced quantitatively. Agreement of the computed models with observation indicates that the binary system SV Cen is actually in the phase of rapid mass exchange preceding the mass-ratio reversal.

  13. Modelling of series of types of automated trenchless works tunneling

    Science.gov (United States)

    Gendarz, P.; Rzasinski, R.

    2016-08-01

    Microtunneling is the newest method for making underground installations. Show method is the result of experience and methods applied in other, previous methods of trenchless underground works. It is considered reasonable to elaborate a series of types of construction of tunneling machines, to develop this particular earthworks method. There are many design solutions of machines, but the current goal is to develop non - excavation robotized machine. Erosion machines with main dimensions of the tunnels which are: 1600, 2000, 2500, 3150 are design with use of the computer aided methods. Series of types of construction of tunneling machines creating process was preceded by analysis of current state. The verification of practical methodology of creating the systematic part series was based on the designed erosion machines series of types. There were developed: method of construction similarity of the erosion machines, algorithmic methods of quantitative construction attributes variant analyzes in the I-DEAS advanced graphical program, relational and program parameterization. There manufacturing process of the parts will be created, which allows to verify the technological process on the CNC machines. The models of designed will be modified and the construction will be consulted with erosion machine users and manufacturers like: Tauber Rohrbau GmbH & Co.KG from Minster, OHL ZS a.s. from Brna,. The companies’ acceptance will result in practical verification by JUMARPOL company.

  14. A dynamic stall model for airfoils with deformable trailing edges

    DEFF Research Database (Denmark)

    Andersen, Peter Bjørn; Gaunaa, Mac; Bak, Christian

    2009-01-01

    , lead-lag, pitch, trailing-edge flapping. In the linear region, the model reduces to the inviscid model, which includes the aerodynamic effect of a thin airfoil with a deformable camberline in inviscid flow. Therefore, the proposed model can be considered a crossover between the work of Gaunaa......The present work contains an extension of the Beddoes-Leishman-type dynamic stall model. In this work, a deformable trailing-edge flap has been added to the dynamic stall model. The model predicts the unsteady aerodynamic forces and moments on an airfoil section undergoing arbitrary motion in heave...... for the attached flow region and Hansen et al. The model is compared qualitatively to wind tunnel measurements of a Riso/ B1-18 blade section equipped with deformable trailing-edge flap devices in the form of piezoelectric devices. Copyright © 2009 John Wiley & Sons, Ltd....

  15. Models for dose assessments. Modules for various biosphere types

    Energy Technology Data Exchange (ETDEWEB)

    Bergstroem, U.; Nordlinder, S.; Aggeryd, I. [Studsvik Eco and Safety AB, Nykoeping (Sweden)

    1999-12-01

    The main objective of this study was to provide a basis for illustrations of yearly dose rates to the most exposed individual from hypothetical leakages of radionuclides from a deep bedrock repository for spent nuclear fuel and other radioactive waste. The results of this study will be used in the safety assessment SR 97 and in a study on the design and long-term safety for a repository planned to contain long-lived low and intermediate level waste. The repositories will be designed to isolate the radionuclides for several hundred thousands of years. In the SR 97 study, however, hypothetical scenarios for leakage are postulated. Radionuclides are hence assumed to be transported in the geosphere by groundwater, and probably discharge into the biosphere. This may occur in several types of ecosystems. A number of categories of such ecosystems were identified, and turnover of radionuclides was modelled separately for each ecosystem. Previous studies had focused on generic models for wells, lakes and coastal areas. These models were, in this study, developed further to use site-specific data. In addition, flows of groundwater, containing radionuclides, to agricultural land and peat bogs were considered. All these categories are referred to as modules in this report. The forest ecosystems were not included, due to a general lack of knowledge of biospheric processes in connection with discharge of groundwater in forested areas. Examples of each type of module were run with the assumption of a continuous annual release into the biosphere of 1 Bq for each radionuclide during 10 000 years. The results are presented as ecosystem specific dose conversion factors (EDFs) for each nuclide at the year 10 000, assuming stationary ecosystems and prevailing living conditions and habits. All calculations were performed with uncertainty analyses included. Simplifications and assumptions in the modelling of biospheric processes are discussed. The use of modules may be seen as a step

  16. Models for dose assessments. Modules for various biosphere types

    International Nuclear Information System (INIS)

    Bergstroem, U.; Nordlinder, S.; Aggeryd, I.

    1999-12-01

    The main objective of this study was to provide a basis for illustrations of yearly dose rates to the most exposed individual from hypothetical leakages of radionuclides from a deep bedrock repository for spent nuclear fuel and other radioactive waste. The results of this study will be used in the safety assessment SR 97 and in a study on the design and long-term safety for a repository planned to contain long-lived low and intermediate level waste. The repositories will be designed to isolate the radionuclides for several hundred thousands of years. In the SR 97 study, however, hypothetical scenarios for leakage are postulated. Radionuclides are hence assumed to be transported in the geosphere by groundwater, and probably discharge into the biosphere. This may occur in several types of ecosystems. A number of categories of such ecosystems were identified, and turnover of radionuclides was modelled separately for each ecosystem. Previous studies had focused on generic models for wells, lakes and coastal areas. These models were, in this study, developed further to use site-specific data. In addition, flows of groundwater, containing radionuclides, to agricultural land and peat bogs were considered. All these categories are referred to as modules in this report. The forest ecosystems were not included, due to a general lack of knowledge of biospheric processes in connection with discharge of groundwater in forested areas. Examples of each type of module were run with the assumption of a continuous annual release into the biosphere of 1 Bq for each radionuclide during 10 000 years. The results are presented as ecosystem specific dose conversion factors (EDFs) for each nuclide at the year 10 000, assuming stationary ecosystems and prevailing living conditions and habits. All calculations were performed with uncertainty analyses included. Simplifications and assumptions in the modelling of biospheric processes are discussed. The use of modules may be seen as a step

  17. Estudo da microcirculação na hanseníase virchowiana com o uso da microscopia de luz ortogonal polarizada e com laser-doppler fluxometria

    OpenAIRE

    Curt Mafra Treu

    2010-01-01

    A hanseníase é uma doença infecciosa com características únicas, dentre elas o fato de atingir intensamente a inervação da pele e seus anexos. Entremeando estes anexos, está a microcirculação cutânea, que a principio também tem sua inervação comprometida. Vários artigos apontam para alterações de disautonomia microcirculatória, citando como exemplo as alterações no reflexo vasomotor. O presente estudo se propõe a avaliar a microcirculação cutânea na hanseníase virchowiana, tanto em sua morfol...

  18. Prevenção de incapacidade na hanseníase com apoio em um manual de autocuidado para pacientes

    OpenAIRE

    Rodini,Fernanda Carvalho Batista; Gonçalves,Mayara; Barros,Ana Regina de Souza Bavaresco; Mazzer,Nilton; Elui,Valéria Meirelles Carril; Fonseca,Marisa de Cássia Registro

    2010-01-01

    A hanseníase é uma doença infectocontagiosa, de evolução lenta, que se manifesta por sinais e sintomas dermatoneurológicos, com lesões na pele e nos nervos periféricos. O objetivo deste estudo foi avaliar o status físico e funcional de olhos, mãos e pés de pacientes com hanseníase, em relação ao aparecimento e evolução de deficiências sensitivo-motoras, grau de incapacidade e qualidade de vida, tendo os pacientes recebido e utilizado durante um ano um manual especialmente elaborado, com orien...

  19. Avaliação da dor em portadores de hanseníase submetidos à mobilização neural

    OpenAIRE

    Véras,Larissa Sales Téles; Vale,Rodrigo Gomes de Souza; Mello,Danielli Braga de; Castro,José Adail Fonseca de; Dantas,Estélio Henrique Martin

    2011-01-01

    Este estudo tem como objetivo avaliar o efeito da técnica de mobilização neural sobre a percepção da dor em portadores de hanseníase. A amostra de 56 indivíduos portadores de hanseníase foi randomizada em: grupo experimental (GMN) composto por 29 indivíduos submetidos ao tratamento com mobilização neural e grupo controle (GC) composto por 27 indivíduos que foram submetidos ao tratamento convencional. A percepção da dor foi avaliada através da Escala Visual Analógica, indicando-se em uma extre...

  20. Hanseníase e vulnerabilidade social: uma análise do perfil socioeconômico de usuários em tratamento irregular

    Directory of Open Access Journals (Sweden)

    Viviane Aparecida Siqueira Lopes

    Full Text Available Este artigo analisa a determinação social da hanseníase, a partir do reconhecimento da vulnerabilidade social dos usuários em tratamento irregular, no Programa de Controle da Hanseníase do município de Campos dos Goytacazes (RJ. Para isso, apresenta uma pesquisa documental, com base nas Fichas de Cadastro Social dos usuários mencionados, destacando aspectos como trabalho, renda, formação familiar e acesso a políticas públicas. Seus resultados registram significativa presença de trabalho precarizado associado a baixos níveis de renda e de escolaridade, sendo a maioria considerada pobre ou indigente (51,5% e não usuária de benefícios assistenciais (66,7%.

  1. Detecção de casos novos de hanseníase no município de Prudentópolis, PR: uma análise de 1998 a 2005

    OpenAIRE

    Sanches,Lucas Augusto Thomé; Pittner,Elaine; Sanches,Hermes Francisco; Monteiro,Marta Chagas

    2007-01-01

    Este trabalho teve como objetivo detectar os casos novos de hanseníase do período de 1998 a 2005 no município de Prudentópolis, PR. Assim como, verificar a faixa etária e a forma clínica predominante entre os casos de hanseníase. Os dados foram obtidos através das fichas clínico-epidemiológicas de casos com diagnóstico definitivo de hanseníase notificado no Sistema de Informação sobre Agravos de Notificação, de 1998 a 2005. Neste período, foram relatados 222 casos de hanseníase, dos quais 63%...

  2. Creep modelling of type 316LN stainless steel

    International Nuclear Information System (INIS)

    Kim, W. G.; Kim, D. H.; Ryu, W. S.

    2000-01-01

    Creep curve for type 316LN stainless steel was modelled by using the K-R damage equations. Seven coefficients used in the model, i. e., A, B, κ, m, λ, r, and q were determined from theoretical and calculated data, and their meanings were also analyzed. To quantify damage formation parameter(ω), cavity amount was measured on the crept specimen taken from an interrupted creep test with time variation, and then the amount was reflected into K-R damage equations. Coefficient λ which is regarded as a creep tolerance feature of a material increased with increase of creep strain. Theoretical curve in λ= 3.0 well coincided with an experimental one to the full level of lifetime. Master curve between damage parameter and life fraction matched with the theoretical one in exponent γ= 24 value, which decreased with increase of parameter ω which increased rapidly after 80% life fraction. It is concluded that K-R equation was reliable as the modelling equation for 316LN stainless steel. Coefficient data obtained from 316LN stainless steel can be utilized for remaining life prediction of operating material

  3. Early light curves for Type Ia supernova explosion models

    Science.gov (United States)

    Noebauer, U. M.; Kromer, M.; Taubenberger, S.; Baklanov, P.; Blinnikov, S.; Sorokina, E.; Hillebrandt, W.

    2017-12-01

    Upcoming high-cadence transient survey programmes will produce a wealth of observational data for Type Ia supernovae. These data sets will contain numerous events detected very early in their evolution, shortly after explosion. Here, we present synthetic light curves, calculated with the radiation hydrodynamical approach STELLA for a number of different explosion models, specifically focusing on these first few days after explosion. We show that overall the early light curve evolution is similar for most of the investigated models. Characteristic imprints are induced by radioactive material located close to the surface. However, these are very similar to the signatures expected from ejecta-CSM or ejecta-companion interaction. Apart from the pure deflagration explosion models, none of our synthetic light curves exhibit the commonly assumed power-law rise. We demonstrate that this can lead to substantial errors in the determination of the time of explosion. In summary, we illustrate with our calculations that even with very early data an identification of specific explosion scenarios is challenging, if only photometric observations are available.

  4. Study of physiological properties of some probiotics in multiple cultures with mesophilic lactic acid bacteria by Flora Danica Ch. Hansen commercial starter

    OpenAIRE

    DANIELA PARASCHIV; AIDA VASILE; MADALINA CONSTANTIN; ALEXANDRU CIOBANU; GABRIELA BAHRIM

    2011-01-01

    The aim of this study was to establish the growth ability and stability of probiotic strains Lactobacillus acidophilus (commercial code La-5®), Lactobacillus casei ssp. paracasei (commercial code L. casei 431®) and Bifidobacterium bifidus (commercial code BB-12®) in multiple cultures with mesophilic lactic bacteria, Lactococcus lactis ssp. cremoris, Lactococcus lactis ssp. lactis, Lactococcus lactis ssp. diacetylactis and Leuconostoc mesenteroides spp. cremoris, as Flora Danica Chr. Hansen co...

  5. Perfil clínico-epidemiológico da hanseníase em menores de 15 anos no município de Juazeiro-BA

    Directory of Open Access Journals (Sweden)

    Igara Cavalcanti Feitosa Luna

    2013-06-01

    Full Text Available Objetivo: Descrever o perfil epidemiológico e clínico dos casos novos de hanseníase em menores de 15 anos notificados à Secretaria Municipal de Saúde (SMS de Juazeiro-BA, no período de 2001 a 2010. Métodos: Trata-se de um estudo quantitativo, de natureza exploratória e descritiva, realizado a partir da análise dos dados contidos no Sistema de Informação de Agravos de Notificação (SINAN municipal. Resultados: Os resultados mostraram que145 (7,94% casos novos de hanseníase ocorreram em menores de 15 anos. Verificaram-se taxas de detecção altas para essa faixa etária, com predominância no sexo feminino (n=81; 55,86% e maior acometimento na faixa etária entre 10 e 14 anos (n=85; 58,62%. As formas paucibacilares (n=107; 74,48% da doença predominaram sobre as formas multibacilares (n=37; 25,52%, sendo a forma clínica tuberculoide (n=80; 55,17% a mais prevalente. As incapacidades atingiram 18 (12,41% dos pacientes avaliados no diagnóstico e 15 (10,34% na alta. Uma grande parte de casos (n=58; 40,07% deixou de ser avaliada ou foi ignorada. Conclusão: O perfil epidemiológico e clínico da ocorrência de casos novos de hanseníase no município de Juazeiro-BA evidenciou que os coeficientes de detecção geral de hanseníase e em menores de 15 anos se mantiveram em nível hiperendêmico no período avaliado.

  6. Tendências da hanseníase no Tocantins, um estado hiperendêmico do Norte do Brasil, 2001-2012

    Directory of Open Access Journals (Sweden)

    Lorena Dias Monteiro

    2015-05-01

    Full Text Available A hanseníase é hiperendêmica no Estado do Tocantins, Brasil. O objetivo do estudo foi analisar as tendências dos indicadores da hanseníase no Tocantins em 2001-2012. Análise de dados advindos do Sistema de Informação de Agravos de Notificação (SINAN. Incluíram-se casos novos de residentes no Tocantins. Calcularam-se os indicadores da hanseníase e analisaram-se as tendências temporais por meio de regressão polinomial. Houve tendência significativa e decrescente para a detecção geral (R2 = 0,40; p 0,05, detecção de casos com grau 2 de incapacidade física (R2 = 0,37; p > 0,05 e proporção de casos com grau 2 (R2 = 0,49; p > 0,05. Houve aumento significativo para a proporção de casos com grau 1 de incapacidade (R2 = 0,82; p < 0,05 e proporção de casos multibacilares (R2 = 0,81; p < 0,05. O Tocantins apresenta regiões com alta transmissão e diagnóstico tardio da hanseníase, apontando a expansão da doença de forma heterogênea na análise temporal.

  7. Amiloidose e insuficiência renal crônica terminal associada à hanseníase Amyloidosis and end-stage renal disease associated with leprosy

    Directory of Open Access Journals (Sweden)

    Geraldo Bezerra da Silva Júnior

    2010-08-01

    Full Text Available O envolvimento renal na hanseníase é diverso, incluindo glomerulonefrites, amiloidose e nefrite túbulo-intersticial. Um homem de 58 anos foi admitido com edema de membros inferiores e dispnéia. Na admissão, havia retenção de escórias nitrogenadas, anemia, hipercalemia e acidose metabólica, com necessidade de hemodiálise. Referia história de hanseníase virchoviana. Foi realizada biopsia renal, compatível com amiloidose. O paciente evoluiu estável, sem recuperação da função renal, permanecendo em tratamento hemodialítico. A hanseníase deve ser investigada em todo paciente com perda de função renal, sobretudo naqueles que apresentam lesões cutâneas ou outras manifestações sugestivas de hanseníase.Renal involvement in leprosy includes glomerulonephritis, amyloidosis and tubulointerstitial nephritis. A 58-year-old man was admitted with complaints of lower limb edema and dyspnea. At admission, nitrogen retention, anemia, hyperkalemia and metabolic acidosis were observed, requiring hemodialysis. The patient had a history of lepromatous leprosy. A renal biopsy was performed that was compatible with amyloidosis. The patient had a stable outcome, but without renal function recovery and remained on regular hemodialysis. Leprosy should be investigated in every patient with renal function loss, particularly in those with cutaneous lesions or other manifestations suggestive of leprosy.

  8. Impact of model structure and parameterization on Penman-Monteith type evaporation models

    KAUST Repository

    Ershadi, A.

    2015-04-12

    The impact of model structure and parameterization on the estimation of evaporation is investigated across a range of Penman-Monteith type models. To examine the role of model structure on flux retrievals, three different retrieval schemes are compared. The schemes include a traditional single-source Penman-Monteith model (Monteith, 1965), a two-layer model based on Shuttleworth and Wallace (1985) and a three-source model based on Mu et al. (2011). To assess the impact of parameterization choice on model performance, a number of commonly used formulations for aerodynamic and surface resistances were substituted into the different formulations. Model response to these changes was evaluated against data from twenty globally distributed FLUXNET towers, representing a cross-section of biomes that include grassland, cropland, shrubland, evergreen needleleaf forest and deciduous broadleaf forest. Scenarios based on 14 different combinations of model structure and parameterization were ranked based on their mean value of Nash-Sutcliffe Efficiency. Results illustrated considerable variability in model performance both within and between biome types. Indeed, no single model consistently outperformed any other when considered across all biomes. For instance, in grassland and shrubland sites, the single-source Penman-Monteith model performed the best. In croplands it was the three-source Mu model, while for evergreen needleleaf and deciduous broadleaf forests, the Shuttleworth-Wallace model rated highest. Interestingly, these top ranked scenarios all shared the simple lookup-table based surface resistance parameterization of Mu et al. (2011), while a more complex Jarvis multiplicative method for surface resistance produced lower ranked simulations. The highly ranked scenarios mostly employed a version of the Thom (1975) formulation for aerodynamic resistance that incorporated dynamic values of roughness parameters. This was true for all cases except over deciduous broadleaf

  9. Analysis of Hansen's Inferior and Superior Partial Anomalies and the Division of the Elliptic Orbit into Two Segments

    Science.gov (United States)

    Sharaf, M. A.; Saad, A. S.

    2017-10-01

    In this paper, a novel analysis was established to prove how Hansen's inferior and superior partial anomalies k and k_1 can divide the elliptic orbit into two segments. The analysis depends on the departures of r (for k) and 1/r (for k1) from their minima. By these departures, we can find: (i) Transformations relating the eccentric anomaly to k and the true anomaly to k1. (ii) Expressions for k and k_1 in terms of the orbital elements. (iii) The interpretation and the intervals of definition of two moduli (X, S) related to k and k_1. (iv) The extreme values of r and the elliptic equations in terms of k and k1. (v) For r' and r'', the modulus X as a measure of the asymmetry of r' (or r'') from r'' (or r'), and the modulus S12 as a measure of the asymmetry of r' and r'' from the minimum value of r. (vi) A description of the segments represented by k and k1. (vii) The relative position of the radius vector at k0° and k1=180°.

  10. Hanseníase históide de localização restrita Histoid leprosy of restricted location

    Directory of Open Access Journals (Sweden)

    Antônio Pedro Mendes Schettini

    2008-10-01

    Full Text Available A hanseníase permanece importante problema de saúde pública, e os técnicos de unidades básicas de saúde devem estar capacitados para reconhecer as diversas formas de apresentação clínica da doença. Relata-se caso de paciente com lesões pouco habituais, cujo diagnóstico foi importante por se tratar de doente multibacilar, principal elo da cadeia de transmissão da doença. O diagnóstico e tratamento oportuno desses casos contribuem para atingir as metas de eliminação da doença no país.Leprosy remains a public health problem in Brazil. Every health professional at the primary health care level should be able to detect all presentation forms of leprosy. We report the case of a multibacillary patient with unusual lesions, whose diagnosis was important to interfere in the transmission chain. Diagnosis and adequate treatment contribute to reach the leprosy elimination goal in our country.

  11. Type I Shell Galaxies as a Test of Gravity Models

    Energy Technology Data Exchange (ETDEWEB)

    Vakili, Hajar; Rahvar, Sohrab [Department of Physics, Sharif University of Technology, P.O. Box 11365-9161, Tehran (Iran, Islamic Republic of); Kroupa, Pavel, E-mail: vakili@physics.sharif.edu [Helmholtz-Institut für Strahlen-und Kernphysik, Universität Bonn, Nussallee 14-16, D-53115 Bonn (Germany)

    2017-10-10

    Shell galaxies are understood to form through the collision of a dwarf galaxy with an elliptical galaxy. Shell structures and kinematics have been noted to be independent tools to measure the gravitational potential of the shell galaxies. We compare theoretically the formation of shells in Type I shell galaxies in different gravity theories in this work because this is so far missing in the literature. We include Newtonian plus dark halo gravity, and two non-Newtonian gravity models, MOG and MOND, in identical initial systems. We investigate the effect of dynamical friction, which by slowing down the dwarf galaxy in the dark halo models limits the range of shell radii to low values. Under the same initial conditions, shells appear on a shorter timescale and over a smaller range of distances in the presence of dark matter than in the corresponding non-Newtonian gravity models. If galaxies are embedded in a dark matter halo, then the merging time may be too rapid to allow multi-generation shell formation as required by observed systems because of the large dynamical friction effect. Starting from the same initial state, the observation of small bright shells in the dark halo model should be accompanied by large faint ones, while for the case of MOG, the next shell generation patterns iterate with a specific time delay. The first shell generation pattern shows a degeneracy with the age of the shells and in different theories, but the relative distance of the shells and the shell expansion velocity can break this degeneracy.

  12. Tratamiento de la enfermedad de Hansen en Colombia: medicalización y control de la enfermedad a lo largo del siglo XX

    Directory of Open Access Journals (Sweden)

    Natalia Botero-Jaramillo

    2017-09-01

    Full Text Available Objetivo: investigar el tratamiento de la enfermedad de Hansen durante el siglo XX en Colombia, para analizar el proceso de medicalización, la biopolítica, el significado de la curación y su impacto en el control de la enfermedad y en los enfermos. Metodología: estudio histórico, descriptivo y analítico sobre los tratamientos para la enfermedad de Hansen a lo largo del siglo XX, por medio de metodologías cualitativas como entrevistas con relatos de vida y entrevistas temáticas, y se trabajó con fuentes documentales primarias y secundarias en archivos nacionales y locales. Resultados y discusión: La enfermedad de Hansen, causada por el microorganismo Mycobacterium leprae, fue controlada mediante el aislamiento y reclusión de los enfermos de lepra en hospitales y lazaretos. El desarrollo de algunos tratamientos y el descubrimiento de la terapia antibiótica, las sulfas, que representó una cura efectiva desde la medicina y su poder político y social, participaron en la transformación de las políticas de manejo de la enfermedad y de la comprensión de la misma, en los Lazaretos de Contratación y Agua de Dios.

  13. Bianchi type-I model with conformally invariant scalar and electromagnetic field

    International Nuclear Information System (INIS)

    Accioly, A.J.; Vaidya, A.N.; Som, M.M.

    1983-01-01

    A Bianchi type-I exact solution of the Einstein theory representing the homogeneous anisotropic models with the electromagnetic field and the conformally invariant scalar field is studied. The solution contains Kasner model, pure electromagnetic and pure scalar models as special cases. It is found that the models evolve from an initial Kasner type to a final open Friedmann type universe. (Author) [pt

  14. Anisotropic Bianchi Type-I and Type-II Bulk Viscous String Cosmological Models Coupled with Zero Mass Scalar Field

    Science.gov (United States)

    Venkateswarlu, R.; Sreenivas, K.

    2014-06-01

    The LRS Bianchi type-I and type-II string cosmological models are studied when the source for the energy momentum tensor is a bulk viscous stiff fluid containing one dimensional strings together with zero-mass scalar field. We have obtained the solutions of the field equations assuming a functional relationship between metric coefficients when the metric is Bianchi type-I and constant deceleration parameter in case of Bianchi type-II metric. The physical and kinematical properties of the models are discussed in each case. The effects of Viscosity on the physical and kinematical properties are also studied.

  15. Another New Solvable Many-Body Model of Goldfish Type

    Directory of Open Access Journals (Sweden)

    Francesco Calogero

    2012-07-01

    Full Text Available A new solvable many-body problem is identified. It is characterized by nonlinear Newtonian equations of motion (''acceleration equal force'' featuring one-body and two-body velocity-dependent forces ''of goldfish type'' which determine the motion ofan arbitrary number $N$ of unit-mass point-particles in a plane. The $N$ (generally complex values $z_{n}(t$ at time $t$ ofthe $N$ coordinates of these moving particles are given by the $N$eigenvalues of a time-dependent $Nimes N$ matrix $U(t$explicitly known in terms of the $2N$ initial data $z_{n}(0$and $dot{z}_{n}(0 $. This model comes in two dif/ferentvariants, one featuring 3 arbitrary coupling constants, the other only 2; for special values of these parameters all solutions are completely periodic with the same period independent of the initial data (''isochrony''; for other special values of these parameters this property holds up to corrections vanishing exponentially as $tightarrow infty$ (''asymptotic isochrony''. Other isochronous variants of these models are also reported. Alternative formulations, obtained by changing the dependent variables from the $N$ zeros of a monic polynomial of degree $N$ to its $N$ coefficients, are also exhibited. Some mathematical findings implied by some of these results - such as Diophantine properties of the zeros of certain polynomials - are outlined, but their analysis is postponed to a separate paper.

  16. Higgs potential in the type II seesaw model

    International Nuclear Information System (INIS)

    Arhrib, A.; Benbrik, R.; Chabab, M.; Rahili, L.; Ramadan, J.; Moultaka, G.; Peyranere, M. C.

    2011-01-01

    The standard model Higgs sector, extended by one weak gauge triplet of scalar fields with a very small vacuum expectation value, is a very promising setting to account for neutrino masses through the so-called type II seesaw mechanism. In this paper we consider the general renormalizable doublet/triplet Higgs potential of this model. We perform a detailed study of its main dynamical features that depend on five dimensionless couplings and two mass parameters after spontaneous symmetry breaking, and highlight the implications for the Higgs phenomenology. In particular, we determine (i) the complete set of tree-level unitarity constraints on the couplings of the potential and (ii) the exact tree-level boundedness from below constraints on these couplings, valid for all directions. When combined, these constraints delineate precisely the theoretically allowed parameter space domain within our perturbative approximation. Among the seven physical Higgs states of this model, the mass of the lighter (heavier) CP even state h 0 (H 0 ) will always satisfy a theoretical upper (lower) bound that is reached for a critical value μ c of μ (the mass parameter controlling triple couplings among the doublet/triplet Higgses). Saturating the unitarity bounds, we find an upper bound m h 0 or approx. μ c and μ c . In the first regime the Higgs sector is typically very heavy, and only h 0 that becomes SM-like could be accessible to the LHC. In contrast, in the second regime, somewhat overlooked in the literature, most of the Higgs sector is light. In particular, the heaviest state H 0 becomes SM-like, the lighter states being the CP odd Higgs, the (doubly) charged Higgses, and a decoupled h 0 , possibly leading to a distinctive phenomenology at the colliders.

  17. Implementation of Electrical Simulation Model for IEC Standard Type-3A Generator

    DEFF Research Database (Denmark)

    Subramanian, Chandrasekaran; Casadei, Domenico; Tani, Angelo

    2013-01-01

    This paper describes the implementation of electrical simulation model for IEC 61400-27-1 standard Type-3A generator. A general overview of the different wind electric generators(WEG) types are given and the main focused on Type-3A WEG standard models, namely a model for a variable speed wind tur...

  18. Mixed models approaches for joint modeling of different types of responses.

    Science.gov (United States)

    Ivanova, Anna; Molenberghs, Geert; Verbeke, Geert

    2016-01-01

    In many biomedical studies, one jointly collects longitudinal continuous, binary, and survival outcomes, possibly with some observations missing. Random-effects models, sometimes called shared-parameter models or frailty models, received a lot of attention. In such models, the corresponding variance components can be employed to capture the association between the various sequences. In some cases, random effects are considered common to various sequences, perhaps up to a scaling factor; in others, there are different but correlated random effects. Even though a variety of data types has been considered in the literature, less attention has been devoted to ordinal data. For univariate longitudinal or hierarchical data, the proportional odds mixed model (POMM) is an instance of the generalized linear mixed model (GLMM; Breslow and Clayton, 1993). Ordinal data are conveniently replaced by a parsimonious set of dummies, which in the longitudinal setting leads to a repeated set of dummies. When ordinal longitudinal data are part of a joint model, the complexity increases further. This is the setting considered in this paper. We formulate a random-effects based model that, in addition, allows for overdispersion. Using two case studies, it is shown that the combination of random effects to capture association with further correction for overdispersion can improve the model's fit considerably and that the resulting models allow to answer research questions that could not be addressed otherwise. Parameters can be estimated in a fairly straightforward way, using the SAS procedure NLMIXED.

  19. Study of experimentally undetermined neutrino parameters in the light of baryogenesis considering type I and type II Seesaw models

    International Nuclear Information System (INIS)

    Kalita, Rupam

    2017-01-01

    We study to connect all the experimentally undetermined neutrino parameters namely lightest neutrino mass, neutrino CP phases and baryon asymmetry of the Universe within the framework of a model where both type I and type II seesaw mechanisms can contribute to tiny neutrino masses. In this work we study the effects of Dirac and Majorana neutrino phases in the origin of matter-antimatter asymmetry through the mechanism of leptogenesis. Type I seesaw mass matrix considered to a tri-bimaximal (TBM) type neutrino mixing which always gives non zero reactor mixing angle. The type II seesaw mass matrix is then considered in such a way that the necessary deviation from TBM mixing and the best fit values of neutrino parameters can be obtained when both type I and type II seesaw contributions are taken into account. We consider different contribution from type I and type II seesaw mechanism to study the effects of neutrino CP phases in the baryon asymmetry of the universe. We further study to connect all these experimentally undetermined neutrino parameters by considering various contribution of type I and type II seesaw. (author)

  20. Significados e usos de materiais educativos sobre hanseníase segundo profissionais de saúde pública do Município do Rio de Janeiro, Brasil Meanings and use of educational materials on Hansen disease according to public health officials in the Municipality of Rio de Janeiro, Brazil

    Directory of Open Access Journals (Sweden)

    Adriana Kelly-Santos

    2009-04-01

    Full Text Available O artigo objetiva refletir sobre os processos comunicativos de Programas de Controle de Hanseníase (PCH do Sistema Único de Saúde (SUS, por meio da análise da recepção de materiais educativos por profissionais de dois serviços de saúde pública no Rio de Janeiro, Brasil. O trabalho discute em que medida a análise de impressos favorece a negociação dos sentidos e das práticas sobre hanseníase vigentes nos PCH. Foram analisados 38 materiais produzidos entre 1993 a 2005, por instituições governamentais e não-governamentais e realizados dois grupos focais com profissionais atuantes no PCH. Durante os grupos focais 6 materiais foram examinados. Os resultados revelaram a verticalidade e fragmentação nos processos comunicativos, expressas pela: ênfase em campanhas, produção centralizada, homogeneização dos públicos e conteúdos e privilégio dado ao saber biomédico. As atividades horizontais e participativas não eram comuns. Foi identificada uma lacuna entre a institucionalização do discurso da hanseníase, como alternativa à terminologia da lepra, e a sua circulação e consumo entre os diferentes atores sociais.This article reflects on the communications processes in the Hansen Disease Control Programs under the Unified National Health System (SUS in Brazil, analyzing how professionals at two public health services in Rio de Janeiro perceive the educational materials on the disease. The article discusses how analysis of printed materials favors negotiation of prevailing meanings and practices on Hansen disease in the programs. Thirty-eight different educational materials were analyzed (produced from 1993 to 2005 by governmental and nongovernmental institutions through two focus groups with program staff. Six materials were examined during the focus groups. The findings showed the communications processes are vertical and fragmented, with an emphasis on campaigns, centralized production of materials, homogenization of

  1. On wave breaking for Boussinesq-type models

    Science.gov (United States)

    Kazolea, M.; Ricchiuto, M.

    2018-03-01

    We consider the issue of wave breaking closure for Boussinesq type models, and attempt at providing some more understanding of the sensitivity of some closure approaches to the numerical set-up, and in particular to mesh size. For relatively classical choices of weakly dispersive propagation models, we compare two closure strategies. The first is the hybrid method consisting in suppressing the dispersive terms in breaking regions, as initially suggested by Tonelli and Petti in 2009. The second is an eddy viscosity approach based on the solution of a a turbulent kinetic energy. The formulation follows early work by O. Nwogu in the 90's, and some more recent developments by Zhang and co-workers (Ocean Mod. 2014), adapting it to be consistent with the wave breaking detection used here. We perform a study of the behaviour of the two closures for different mesh sizes, with attention to the possibility of obtaining grid independent results. Based on a classical shallow water theory, we also suggest some monitors to quantify the different contributions to the dissipation mechanism, differentiating those associated to the scheme from those of the partial differential equation. These quantities are used to analyze the dynamics of dissipation in some classical benchmarks, and its dependence on the mesh size. Our main results show that numerical dissipation contributes very little to the the results obtained when using eddy viscosity method. This closure shows little sensitivity to the grid, and may lend itself to the development and use of non-dissipative/energy conserving numerical methods. The opposite is observed for the hybrid approach, for which numerical dissipation plays a key role, and unfortunately is sensitive to the size of the mesh. In particular, when working, the two approaches investigated provide results which are in the same ball range and which agree with what is usually reported in literature. With the hybrid method, however, the inception of instabilities

  2. The genetic background affects the vascular response in T-type calcium channels 3.2 deficient mice

    DEFF Research Database (Denmark)

    Svenningsen, Per; Hansen, Pernille B L

    2016-01-01

    -type channels are the dominant Ca(2+) entry pathway in vascular smooth muscle cells, however, T-type calcium channels are also expressed in the cardiovascular system where they play a functional role in the regulation of both contraction and vasodilation in (Chen et al. 2003; Hansen et al. 2001). This article...... is protected by copyright. All rights reserved....

  3. Eye Typing using Markov and Active Appearance Models

    DEFF Research Database (Denmark)

    Hansen, Dan Witzner; Hansen, John Paulin; Nielsen, Mads

    2002-01-01

    We propose a non-intrusive eye tracking system intended for the use of everyday gaze typing using web cameras. We argue that high precision in gaze tracking is not needed for on-screen typing due to natural language redundancy. This facilitates the use of low-cost video components for advanced...

  4. Vigilância da hanseníase em Olinda, Brasil, utilizando técnicas de análise espacial Leprosy surveillance in Olinda, Brazil, using spatial analysis techniques

    Directory of Open Access Journals (Sweden)

    Tiago Lapa

    2001-10-01

    Full Text Available Contribui-se com o sistema de Vigilância Epidemiológica em nível local por meio de análise espacial em razão do predomínio do caráter urbano da hanseníase em nosso meio e por sua distribuição não homogênea - em parte, pela forma de ocupação e transformação do espaço urbano. Trabalha-se o conceito de risco coletivo pela definição de micro-áreas homogêneas mediante o indicador de carência social, verificando-se sua coerência com padrões da distribuição da hanseníase obtidos da base de dados do SINAN para o Município de Olinda no período 1991-96. Para cada estrato, definido segundo níveis semelhantes dos indicadores, foi calculado o coeficiente de detecção médio para o período. Ao exame da associação entre carência social (risco e coeficiente de detecção de hanseníase obteve-se coeficiente de explicação de 66,1% no modelo multiplicativo, acrescido para 84,3% com a variável renda. Para atender à lógica de intervenção, definiram-se estratos de alto, médio e baixo risco nos distritos sanitários e área programática. A construção desses mapas mostrou-se útil a instrumentalizar o planejamento em nível local.In the State of Pernambuco, Brazil, leprosy has been mainly an urban disease, with an uneven geographical distribution related at least partially to the way urban space has been occupied and transformed. Spatial analysis may thus become an important tool to establish an epidemiological surveillance system for leprosy. Homogeneous micro-areas were defined in the city of Olinda through the integration of two databases, the Population Census and SINAN, and through the use of digital maps and geoprocessing techniques. Census tracts were classified according to a social deprivation index (SDI, and micro-area homogeneity was based on similar values for this indicator. Cluster analysis (K-means was used to define cut-offs between strata. The same procedure was repeated using the income variable only

  5. Chaos in long-term behavior of some Bianchi-type VIII models

    Energy Technology Data Exchange (ETDEWEB)

    Halpern, P

    1987-01-01

    The long-term behavior of Bianchi-type VIII models with three different types of stress-energy tensors are examined and compared. The vacuum model, a matter-filled model, and a model with an electromagnetic field are considered. In each case the existence of chaotic behavior and transitions to chaotic behavior are discussed.

  6. Properties of Deflagration Fronts and Models for Type IA Supernovae

    Science.gov (United States)

    Domínguez, I.; Höflich, P.

    2000-01-01

    Detailed models of the explosion of a white dwarf that include self-consistent calculations of the light curve and spectra provide a link between observational quantities and the underlying explosion model. These calculations assume spherical geometry and are based on parameterized descriptions of the burning front. Recently, the first multidimensional calculations for nuclear burning fronts have been performed. Although a fully consistent treatment of the burning fronts is beyond the current state of the art, these calculations provide a new and better understanding of the physics. Several new descriptions for flame propagation have been proposed by Khokhlov et al. and Niemeyer et al. Using various descriptions for the propagation of a nuclear deflagration front, we have studied the influence on the results of previous analyses of Type Ia supernovae, namely, the nucleosynthesis and structure of the expanding envelope. Our calculations are based on a set of delayed detonation models with parameters that give a good account of the optical and infrared light curves and of the spectral evolution. In this scenario, the burning front first propagates in a deflagration mode and subsequently turns into a detonation. The explosions and light curves are calculated using a one-dimensional Lagrangian radiation-hydro code including a detailed nuclear network. We find that the results of the explosion are rather insensitive to details of the description of the deflagration front, even if its speed and the time from the transition to detonation differ almost by a factor of 2. For a given white dwarf (WD) and a fixed transition density, the total production of elements changes by less than 10%, and the distribution in the velocity space changes by less than 7%. Qualitatively, this insensitivity of the final outcome of the explosion to the details of the flame propagation during the (slow) deflagration phase can be understood as follows: for plausible variations in the speed of

  7. Hanseníase: a realidade do ser adolescente Lepra: la realidad para el adolescente Leprosy: the reality for the adolescent

    Directory of Open Access Journals (Sweden)

    Keila Maria de Azevedo Ponte

    2005-06-01

    Full Text Available A hanseníase é uma doença contagiosa, estigmatizante, de grande potencial incapacitante, e os adolescentes por estarem numa fase de mudanças e de adaptação, esta doença pode interferir na construção de sua vida. O estudo objetiva caracterizar os adolescentes portadores de hanseníase segundo aspectos sócio-demograficos; realizar análise epidemiológico-operacional da hanseníase; verificar o conhecimento dos adolescentes sobre a hanseníase e as reações manifestadas pelos mesmos após sua descoberta; Identificar as mudanças ocorridas após a doença na vida do adolescente e as dificuldades vivenciadas pelo mesmo após a da doença. Trata-se de uma pesquisa exploratória e descritiva, constituída de 31 adolescentes portadores de hanseníase, assistido pela Estratégia Saúde da Família no Município de Sobral- Ceará. Os resultados sinalizam a necessidade de uma assistência integral e continuada ao adolescente portador de hanseníase, evitando que essa doença provoque mudanças significativas em sua vida, dificultando na construção de sua nova identidade.La lepra es una enfermedad contagiosa, de un gran potencial incapacitante y los adolescentes por estaren viviendo en una fase de cambios e adaptación esta enfermedad puede interferir en la construcción de sus vidas. Esta investigación apunta caracterizar los adolescentes portadores de lepra según aspectos sociales-demográficos; hacer un análisis epidémico-operacional de la enfermedad lepra; verificar el conocimiento de los adolescentes sobre la lepra y las relaciones manifestadas por los mismos después de su descubierta; identificar los cambios ocurridos en la vida del adolescente después de la descubierta de la enfermedad. Tratase de una investigación exploratoria y descriptiva donde participarón 31 adolescentes portadores de lepra ayudados por la Estrategia Salud de la Familia en el municipio de Sobral - Ceará. Los resultados señalan la necesidad de una

  8. Hanseníase virchowiana associada ao uso de inibidor do fator de necrose tumoral α: relato de caso Lepromatous leprosy associated with the use of anti-TNF α therapy: case report

    Directory of Open Access Journals (Sweden)

    Daniele S Freitas

    2010-06-01

    Full Text Available A terapia anti-TNFα tem sido amplamente utilizada em diversas artropatias inflamatórias crônicas, em especial artrite reumatoide (AR. No entanto, há preocupações quanto à segurança e ao risco de doenças infecciosas nos pacientes. O objetivo deste artigo é descrever um caso de hanseníase, forma virchowiana, em paciente com AR em uso de terapia anti-TNFα. Dessa forma, a vigilância dos eventos adversos deve ser rigorosa, especialmente no que diz respeito às doenças infecciosas. É recomendada investigação apropriada de lesões cutâneas em paciente recebendo terapia anti-TNFα, visto que o quadro clínico inicial pode ser inespecífico, especialmente em regiões endêmicas como o Brasil.TNF blockers have been used in the treatment of several types of chronic inflammatory arthritis, especially rheumatoid arthritis. However, many doubts regarding the safety and high risk of infectious diseases in these patients remain. The main objective of this report was to present a case of lepromatous leprosy in a rheumatoid arthritis patient using TNF blockers. The development of adverse events should be rigorously observed, especially those related to infectious agents. Thus, appropriate investigation of skin lesions in patients receiving anti-TNFa therapy is recommended, as the initial clinical manifestation may be unusual, particularly in endemic regions in Brazil.

  9. Validation of the Monte Carlo criticality program KENO IV and the Hansen-Roach sixteen-energy-group-cross sections for high-assay uranium systems

    International Nuclear Information System (INIS)

    Handley, G.R.; Masters, L.C.; Stachowiak, R.V.

    1981-01-01

    Validation of the Monte Carlo criticality code, KENO IV, and the Hansen-Roach sixteen-energy-group cross sections was accomplished by calculating the effective neutron multiplication constant, k/sub eff/, of 29 experimentally critical assemblies which had uranium enrichments of 92.6% or higher in the uranium-235 isotope. The experiments were chosen so that a large variety of geometries and of neutron energy spectra were covered. Problems, calculating the k/sub eff/ of systems with high-uranium-concentration uranyl nitrate solution that were minimally reflected or unreflected, resulted in the separate examination of five cases

  10. Atingidos pela hanseníase, reparados pelo Estado : as múltiplas histórias performadas da Lei 11.520/2007

    OpenAIRE

    Glaucia Cristina Maricato Moreto

    2015-01-01

    Esta dissertação gira em torno da lei nº 11.520, que em setembro de 2007 estabeleceu o direito a uma pensão especial a todas as pessoas atingidas pela hanseníase e compulsoriamente internadas em colônias hospitalares até 31 de dezembro de 1986. Por um lado, alinhado ao trabalho de diversas pesquisadoras, tais como Vianna (2013), Bevilaqua (2013), Schuch (2008), Das e Polle (2008), Vecchioli (2001) e Ferreira (2009), o enfoque não é direcionado à letra da lei 11.520/2007 (enquanto conjunto de ...

  11. Sorologia da hanseníase utilizando PGL-I: revisão sistemática Leprosy serology using PGL-I: a systematic review

    OpenAIRE

    Rodrigo Scaliante de Moura; Karla Lucena Calado; Maria Leide W. Oliveira; Samira Bührer-Sékula

    2008-01-01

    A sorologia utilizando o antígeno espécie-específico do Mycobacterium leprae, PGL-I, pode ser um marcador de carga bacteriana em pacientes com hanseníase. Estudos identificaram potencial de uso da sorologia na classificação de pacientes para fins de tratamento, monitoramento de terapia, risco de recidiva e na seleção dos contatos com maior risco de adoecer. Foi realizada uma revisão sistemática e 26 artigos foram incluídos na análise comparativa. Avaliamos os resultados do uso da sorologia PG...

  12. Estudo comparativo preliminar entre os alongamentos proprioceptivo e estático passivo em pacientes com seqüelas de hanseníase

    OpenAIRE

    Diaz, Augusto Floricel; Moro, Fabio Luiz; Binotto, Jussara Machado; Fréz, Andersom Ricardo

    2008-01-01

    A proposta deste estudo foi comparar a aplicação de alongamento estático passivo e alongamento proprioceptivo no tratamento de seqüelas de hanseníase. Doze pacientes com essas seqüelas participaram da pesquisa, separados aleatoriamente em dois grupos: o grupo FNP, tratado com facilitação neuromuscular proprioceptiva, e o grupo AEP, com alongamento estático passivo. Ambos realizaram dez sessões de alongamentos, sendo submetidos à avaliação inicial e final nas quais foram aplicados o questionár...

  13. Conformally flat tilted Bianchi Type-V cosmological models in ...

    Indian Academy of Sciences (India)

    the complete determination of these quantities, we assume two extra conditions. First we assume that the space-time is conformally flat which leads to. 1008 .... Discussions. The model starts expanding with a big-bang at М = 0 and the expansion in the model stops at М = ∞ and = -2(Т + 2)¬. The model in general represents.

  14. Discriminating neutrino mass models using Type-II see-saw formula

    Indian Academy of Sciences (India)

    though a fuller analysis needs the full matrix form when all terms are present. This is followed by the normal hierarchical model (Type [III]) and inverted hierarchical model with opposite CP phase (Type [IIB]). γ ≃ 10−2 for both of them. Our main results on neutrino masses and mixings in Type-II see-saw formula are presented ...

  15. Impairment-Factor-Based Audiovisual Quality Model for IPTV: Influence of Video Resolution, Degradation Type, and Content Type

    Directory of Open Access Journals (Sweden)

    Garcia MN

    2011-01-01

    Full Text Available This paper presents an audiovisual quality model for IPTV services. The model estimates the audiovisual quality of standard and high definition video as perceived by the user. The model is developed for applications such as network planning and packet-layer quality monitoring. It mainly covers audio and video compression artifacts and impairments due to packet loss. The quality tests conducted for model development demonstrate a mutual influence of the perceived audio and video quality, and the predominance of the video quality for the overall audiovisual quality. The balance between audio quality and video quality, however, depends on the content, the video format, and the audio degradation type. The proposed model is based on impairment factors which quantify the quality-impact of the different degradations. The impairment factors are computed from parameters extracted from the bitstream or packet headers. For high definition video, the model predictions show a correlation with unknown subjective ratings of 95%. For comparison, we have developed a more classical audiovisual quality model which is based on the audio and video qualities and their interaction. Both quality- and impairment-factor-based models are further refined by taking the content-type into account. At last, the different model variants are compared with modeling approaches described in the literature.

  16. Mineviku pantvangid / Vootele Hansen

    Index Scriptorium Estoniae

    Hansen, Vootele, 1962-

    2001-01-01

    Kommunistliku režiimi kuritegelikkusest. Autor: Rahvaerakond Mõõdukad. Parlamendisaadik. Ilmunud ka: Severnoje Poberezhje, 16. juuni 2001, lk. 2; Meie Maa, 16. juuni 2001, lk. 2; Võrumaa Teataja, 19. juuni 2001, lk. 2; Sakala, 20. juuni 2001, lk. 2; Lääne Elu, 19. juuni 2001, lk. 4

  17. Eelarvamustest lahti / Katt Hansen

    Index Scriptorium Estoniae

    Hansen, Katt

    2003-01-01

    PÖFFi naistekeskseid mängufilme : taanlase Morten Arnfredi "Õnne tänav", tšehh Michaela Pavlatova "Truudusetud mängud", prantsuse filmid "29 Palms" (Bruno Dumont) ja "Väike Lili" (Claude Miller) ning prantsuse-tuneesia "Satin Rouge" (Raja Amari)

  18. Bayesian analysis of Jolly-Seber type models

    Science.gov (United States)

    Matechou, Eleni; Nicholls, Geoff K.; Morgan, Byron J. T.; Collazo, Jaime A.; Lyons, James E.

    2016-01-01

    We propose the use of finite mixtures of continuous distributions in modelling the process by which new individuals, that arrive in groups, become part of a wildlife population. We demonstrate this approach using a data set of migrating semipalmated sandpipers (Calidris pussila) for which we extend existing stopover models to allow for individuals to have different behaviour in terms of their stopover duration at the site. We demonstrate the use of reversible jump MCMC methods to derive posterior distributions for the model parameters and the models, simultaneously. The algorithm moves between models with different numbers of arrival groups as well as between models with different numbers of behavioural groups. The approach is shown to provide new ecological insights about the stopover behaviour of semipalmated sandpipers but is generally applicable to any population in which animals arrive in groups and potentially exhibit heterogeneity in terms of one or more other processes.

  19. Vortex solutions in a Witten-type model

    International Nuclear Information System (INIS)

    Itaya, Satoru; Sawado, Nobuyuki; Suzuki, Michitaka

    2014-01-01

    Straight line vortex solutions in a Witten's superconducting string model are studied. The model has many parameters and this is the main reason of the complexity. We argue the precise conditions of the parameters for finding the solutions of the model. We obtain the rotationally symmetric solutions for the winding numbers m = 1 - 4 with/without the gauge field. For the higher winding numbers, an energy minimization algorithm is used to investigate non-rotational solutions

  20. Consideration of environmental pollution in MESSAGE-type energy models

    International Nuclear Information System (INIS)

    Rentz, O.; Hanicke, T.; Hempelmann, R.

    1981-10-01

    Macroeconomic and microeconomic data are acquired and processed to obtain a model-adequate data base. The MESSAGE model is adapted and implemented. Modifications for specific problems are described. Aspects of environmental pollution are considered for the various energy supply concepts. The model conception is flexible with regard to new technologies, in particular in the field of primary and secondary energy sources, and to cogeneration products (district heat, electric power). (HP) [de

  1. A model for cell type localization in the migrating slug of ...

    Indian Academy of Sciences (India)

    PRAKASH

    . Localization of the three major cell types within the migrating slug stage is a dynamic process (Sternfeld 1992;. A model for cell type localization in the migrating slug of Dictyostelium discoideum based on differential chemotactic sensitivity to ...

  2. Measurement and modelling of evapotranspiration in three fynbos vegetation types

    CSIR Research Space (South Africa)

    Dzikiti, Sebinasi

    2014-04-01

    Full Text Available sites. In this study we determined water use by 3 fynbos vegetation types growing at 4 different sites, namely: (i) lowland Atlantis Sand Plain fynbos growing on deep sandy soils, (ii) Kogelberg Sandstone fynbos growing in a riparian zone on deep...

  3. A Step-indexed Semantic Model of Types for the Call-by-Name Lambda Calculus

    OpenAIRE

    Meurer, Benedikt

    2011-01-01

    Step-indexed semantic models of types were proposed as an alternative to purely syntactic safety proofs using subject-reduction. Building upon the work by Appel and others, we introduce a generalized step-indexed model for the call-by-name lambda calculus. We also show how to prove type safety of general recursion in our call-by-name model.

  4. Modeling Two Types of Adaptation to Climate Change

    Science.gov (United States)

    Mitigation and adaptation are the two key responses available to policymakers to reduce the risks of climate change. We model these two policies together in a new DICE-based integrated assessment model that characterizes adaptation as either short-lived flow spending or long-live...

  5. Acervo de materiais educativos sobre hanseníase: um dispositivo da memória e das práticas comunicativas

    Directory of Open Access Journals (Sweden)

    Adriana Kelly-Santos

    Full Text Available Neste trabalho objetiva-se: descrever o processo de elaboração de um banco de 276 materiais sobre hanseníase produzidos por instituições públicas e não-governamentais, entre 1972-2008; analisar o tipo, o público e os objetivos. O banco foi elaborado numa base eletrônica de dados, contendo a análise descritiva e temática e um link para o documento completo dos materiais. Os materiais destinam-se ao público em geral (75%, profissionais de saúde (12%, público infanto-juvenil (6%, portadores de hanseníase (3% e outros (4%. Predominam panfletos (26%, folhetos (24%, cartazes (23%, seguidos de cartilhas (15%, álbuns seriados (3% e outros (9%. Objetivam aumentar a autossuspeição, detecção de casos e divulgar os serviços de saúde. Predomina o discurso biomédico, a linguagem técnica-prescritiva e as relações hierarquizadas entre enunciador-destinatário.

  6. Acervo de materiais educativos sobre hanseníase: um dispositivo da memória e das práticas comunicativas

    Directory of Open Access Journals (Sweden)

    Adriana Kelly-Santos

    2010-03-01

    Full Text Available Neste trabalho objetiva-se: descrever o processo de elaboração de um banco de 276 materiais sobre hanseníase produzidos por instituições públicas e não-governamentais, entre 1972-2008; analisar o tipo, o público e os objetivos. O banco foi elaborado numa base eletrônica de dados, contendo a análise descritiva e temática e um link para o documento completo dos materiais. Os materiais destinam-se ao público em geral (75%, profissionais de saúde (12%, público infanto-juvenil (6%, portadores de hanseníase (3% e outros (4%. Predominam panfletos (26%, folhetos (24%, cartazes (23%, seguidos de cartilhas (15%, álbuns seriados (3% e outros (9%. Objetivam aumentar a autossuspeição, detecção de casos e divulgar os serviços de saúde. Predomina o discurso biomédico, a linguagem técnica-prescritiva e as relações hierarquizadas entre enunciador-destinatário.

  7. Lifestyle change in type 2 diabetes a process model.

    Science.gov (United States)

    Whittemore, Robin; Chase, Susan K; Mandle, Carol Lynn; Roy, Callista

    2002-01-01

    Integration is an emerging concept in the study of self-management and chronic illness, yet this process and how it occurs is not well understood. This investigation, part of a triangulated study, focused on the experience of integrating type 2 diabetes treatment recommendations into an existing lifestyle while participating in a nurse-coaching intervention. An interpretive method elicited data from nurse-coaching sessions (4), field notes, and an interview in 9 women with type 2 diabetes. The process of data reduction and analysis (Miles & Huberman, 1994) was used to interpret data. The core process of integrating lifestyle change in type 2 diabetes was multifaceted and complex. Challenges to the process of integrating lifestyle change included reconciling emotions, composing a structure, striving for satisfaction, exploring self and conflicts, discovering balance, and developing a new cadence to life. These challenges required acknowledgment in order for participants to progress toward integration. Balance was an integral component to the experience of integration, between structure and flexibility, fear and hope, conflict and acceptance, diabetes and life. Conceptualizations identified with this investigation extend understanding of theories of integration and lifestyle change and invite the development and testing of nursing interventions.

  8. Genome typing of nonhuman primate models: implications for biomedical research.

    Science.gov (United States)

    Haus, Tanja; Ferguson, Betsy; Rogers, Jeffrey; Doxiadis, Gaby; Certa, Ulrich; Rose, Nicola J; Teepe, Robert; Weinbauer, Gerhard F; Roos, Christian

    2014-11-01

    The success of personalized medicine rests on understanding the genetic variation between individuals. Thus, as medical practice evolves and variation among individuals becomes a fundamental aspect of clinical medicine, a thorough consideration of the genetic and genomic information concerning the animals used as models in biomedical research also becomes critical. In particular, nonhuman primates (NHPs) offer great promise as models for many aspects of human health and disease. These are outbred species exhibiting substantial levels of genetic variation; however, understanding of the contribution of this variation to phenotypes is lagging behind in NHP species. Thus, there is a pivotal need to address this gap and define strategies for characterizing both genomic content and variability within primate models of human disease. Here, we discuss the current state of genomics of NHP models and offer guidelines for future work to ensure continued improvement and utility of this line of biomedical research. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Effects of low-dose rate irradiation on two types of type II diabetes model mice

    International Nuclear Information System (INIS)

    Nomura, Takaji; Sakai, Kazuo

    2004-01-01

    The effects of low-dose rate gamma-irradiation were investigated in two mouse strains - C57BL/KsJ-db/db (db mouse) and AKITA (AKITA mouse)-for type II diabetes mellitus. Both strains develop the developed type II diabetes by about 8 weeks of age due to dysfunction of the insulin/insulin receptor. The db Mouse' shows obese and exhibits hyperinsulinism, and the onset of Type II diabetes like resembles that for Westerners. On the other hand, the AKITA mouse has exhibits disordered insulin secretion, and the diabetes such as resembles that of Asians. Ten-week old female mice, in groups of 8 or 12, were irradiated at 0.65 mGy/hr in the low-dose rate irradiation facility in the Low Dose Radiation Research Center. The level of urine glucose was measured with test slips. The urine glucose levels of all of the mice were highly elevated the beginning of the irradiation. In the irradiated group of db mice, three mice showed decrease in glucose level compare to the level of non-irradiated diabetes mice after 35, 52 or 80 weeks of irradiation. All had maintained a normal level thereafter. No such improvement in diabetes was ever observed in the 12 mice of in the non-irradiated control group. The AKITA mice, however, did not decrease the glucose level regardless of the irradiation. Both the db mice and AKITA mice had their lives prolonged their life by the irradiation. The survival rate of db mice at the age of 90 weeks was 75% in the irradiated group, but 50% in the non-irradiated group. The average life span was 104 weeks in the irradiated group and 87 weeks in the control group. Furthermore, a marked difference was furthermore observed in the appearance of the coat hair, skin, and tail; appearances were well preserved in the irradiated group. The average life span in the irradiated AKITA mice was also longer than that for the non-irradiated mice, 51 weeks and 41 weeks in the irradiated and non-irradiated group respectively. These results suggest that the low-dose irradiation

  10. Contrapontos da história da hanseníase no Brasil: cenários de estigma e confinamento Contrapuntos de la historia de la enfermedad de Hansen en Brasil: escenarios de estigma y confinamiento Counterpoints in the history of Hansen's disease in Brazil: situations of stigma and seclusion

    Directory of Open Access Journals (Sweden)

    Luiz Antonio de Castro Santos

    2008-06-01

    Full Text Available Ao discutir a luta contra a hanseníase no Brasil, em especial em São Paulo e no Maranhão, o trabalho focaliza as múltiplas formas da história institucional e da "cultura de reclusão" dos hansenianos. Critica-se a visão corrente de um cenário único de disciplina e vigilância para, ao contrário, sugerir a existência de cenários cambiantes, marcados por conflitos, negociações e distintas propostas de prevenção ou de combate à doença. O texto aborda as diferentes concepções médicas e "profanas" da lepra, bem como as propostas e práticas de intervenção social no Brasil e, em particular, nos estados de São Paulo e do Maranhão, desde os primeiros tempos da República até as primeiras décadas da Era Vargas. O combate à doença sempre desafiou conceitos e convicções sobre tratamento, propagação, confinamento e regeneração, sob múltiplos significados epidemiológicos, médicos, culturais e sociais, referidos ao estigma da doença, do pecado e da impureza. O texto procura estabelecer alguns cenários brasileiros nos quais se revelam as identidades coletivas deterioradas, a exclusão social e as políticas de confinamento institucional e de regeneração dos doentes.Al discutir la lucha contra la enfermedad de Hansen en Brasil, en especial en San Pablo y en Maranhão, el trabajo enfocará las múltiples formas de la historia institucional y de la "cultura de reclusión" de los hansenianos (leprosos. Se critica la visión corriente de un escenario único de disciplina y vigilancia para, al contrario, sugerirse la existencia de escenarios cambiantes, marcados por conflictos, negociaciones y distintas propuestas de prevención o de combate a la enfermedad. El texto abordará las diferentes concepciones médicas y 'profanas' de la lepra, así como las propuestas y prácticas de intervención social en Brasil y, en particular, en los estados de San Pablo y de Maranhão, desde los primeros tiempos de la República hasta las

  11. Explicit chiral symmetry breaking in Gross-Neveu type models

    Energy Technology Data Exchange (ETDEWEB)

    Boehmer, Christian

    2011-07-25

    This thesis is devoted to the study of a 1+1-dimensional, fermionic quantum field theory with Lagrangian L= anti {psi}i{gamma}{sup {mu}}{partial_derivative}{sub {mu}}{psi}-m{sub 0} anti {psi}{psi}+(g{sup 2})/(2)(anti {psi}{psi}){sup 2}+(G{sup 2})/(2)(anti {psi}i{gamma}{sub 5}{psi}){sup 2} in the limit of an infinite number of flavors, using semiclassical methods. The main goal of the present work was to see what changes if we allow for explicit chiral symmetry breaking, either by a bare mass term, or a splitting of the scalar and pseudo-scalar coupling constants, or both. In the first case, this becomes the massive NJL{sub 2} model. In the 2nd and 3rd cases we are dealing with a model largely unexplored so far. The first half of this thesis deals with the massive NJL{sub 2} model. Before attacking the phase diagram, it was necessary to determine the baryons of the model. We have carried out full numerical Hartree-Fock calculations including the Dirac sea. The most important result is the first complete phase diagram of the massive NJL{sub 2} model in ({mu},T,{gamma}) space, where {gamma} arises from m{sub 0} through mass renormalization. In the 2nd half of the thesis we have studied a generalization of the massless NJL{sub 2} model with two different (scalar and pseudoscalar) coupling constants, first in the massless version. Renormalization of the 2 coupling constants leads to the usual dynamical mass by dynamical transmutation, but in addition to a novel {xi} parameter interpreted as chiral quenching parameter. As far as baryon structure is concerned, the most interesting result is the fact that the new baryons interpolate between the kink of the GN model and the massless baryon of the NJL{sub 2} model, always carrying fractional baryon number 1/2. The phase diagram of the massless model with 2 coupling constants has again been determined numerically. At zero temperature we have also investigated the massive, generalized GN model with 3 parameters. It is well

  12. Explicit chiral symmetry breaking in Gross-Neveu type models

    International Nuclear Information System (INIS)

    Boehmer, Christian

    2011-01-01

    This thesis is devoted to the study of a 1+1-dimensional, fermionic quantum field theory with Lagrangian L= anti ψiγ μ ∂ μ ψ-m 0 anti ψψ+(g 2 )/(2)(anti ψψ) 2 +(G 2 )/(2)(anti ψiγ 5 ψ) 2 in the limit of an infinite number of flavors, using semiclassical methods. The main goal of the present work was to see what changes if we allow for explicit chiral symmetry breaking, either by a bare mass term, or a splitting of the scalar and pseudo-scalar coupling constants, or both. In the first case, this becomes the massive NJL 2 model. In the 2nd and 3rd cases we are dealing with a model largely unexplored so far. The first half of this thesis deals with the massive NJL 2 model. Before attacking the phase diagram, it was necessary to determine the baryons of the model. We have carried out full numerical Hartree-Fock calculations including the Dirac sea. The most important result is the first complete phase diagram of the massive NJL 2 model in (μ,T,γ) space, where γ arises from m 0 through mass renormalization. In the 2nd half of the thesis we have studied a generalization of the massless NJL 2 model with two different (scalar and pseudoscalar) coupling constants, first in the massless version. Renormalization of the 2 coupling constants leads to the usual dynamical mass by dynamical transmutation, but in addition to a novel ξ parameter interpreted as chiral quenching parameter. As far as baryon structure is concerned, the most interesting result is the fact that the new baryons interpolate between the kink of the GN model and the massless baryon of the NJL 2 model, always carrying fractional baryon number 1/2. The phase diagram of the massless model with 2 coupling constants has again been determined numerically. At zero temperature we have also investigated the massive, generalized GN model with 3 parameters. It is well-known that the massless NJL 2 model can be solved analytically. The same is true for the GN model, be it massless or massive. Here, the

  13. Soliton-type solutions for two models in mathematical physics

    Science.gov (United States)

    Al-Ghafri, K. S.

    2018-04-01

    In this paper, the generalised Klein-Gordon and Kadomtsov-Petviashvili Benjamin-Bona-Mahony equations with power law nonlinearity are investigated. Our study is based on reducing the form of both equations to a first-order ordinary differential equation having the travelling wave solutions. Subsequently, soliton-type solutions such as compacton and solitary pattern solutions are obtained analytically. Additionally, the peaked soliton has been derived where it exists under a specific restrictions. In addition to the soliton solutions, the mathematical method which is exploited in this work also creates a few amount of travelling wave solutions.

  14. Model Based Analysis of Ethnic Differences in Type 2 Diabetes

    DEFF Research Database (Denmark)

    Møller, Jonas Bech

    the applicability of stochastic differential equations (SDEs) and non-linear mixed effects (NLME) models for such an assessment. One way to perform such an investigation is to characterise the pathophysiology of the two groups at different stages of disease progression. For T2D this involves a characterisation...... equations (SDEs) or another improved description of residuals. For characterising disease progression in Caucasian and Japanese, established models that include parameters for insulin sensitivity and beta-cell function were implemented in a non-linear mixed-effects setting with ODEs. Based on the ACF......-cell function, measured by simple insulin based measures,could be explained by difference in body size (BMI). This was supported by Forest plots of covariate effects obtained from population models, in general indicating that race had no clinical relevant effect on either the insulin sensitivit yor the beta...

  15. Realizing three generations of the Standard Model fermions in the type IIB matrix model

    International Nuclear Information System (INIS)

    Aoki, Hajime; Nishimura, Jun; Tsuchiya, Asato

    2014-01-01

    We discuss how the Standard Model particles appear from the type IIB matrix model, which is considered to be a nonperturbative formulation of superstring theory. In particular, we are concerned with a constructive definition of the theory, in which we start with finite-N matrices and take the large-N limit afterwards. In that case, it was pointed out recently that realizing chiral fermions in the model is more difficult than it had been thought from formal arguments at N=∞ and that introduction of a matrix version of the warp factor is necessary. Based on this new insight, we show that two generations of the Standard Model fermions can be realized by considering a rather generic configuration of fuzzy S"2 and fuzzy S"2×S"2 in the extra dimensions. We also show that three generations can be obtained by squashing one of the S"2’s that appear in the configuration. Chiral fermions appear at the intersections of the fuzzy manifolds with nontrivial Yukawa couplings to the Higgs field, which can be calculated from the overlap of their wave functions.

  16. Model Predictive Control of Buoy Type Wave Energy Converter

    DEFF Research Database (Denmark)

    Soltani, Mohsen; Sichani, Mahdi Teimouri; Mirzaei, Mahmood

    2014-01-01

    by forcing this condition. In the paper the theoretical framework for this principal is shown. The optimal controller requires information of the sea state for infinite horizon which is not applicable. Model Predictive Controllers (MPC) can have finite horizon which crosses out this requirement....... This approach is then taken into account and an MPC controller is designed for a model WEC and implemented on a numerical example. Further, the power outtake of this controller is compared to the optimal controller as an indicator of the performance of the designed controller....

  17. Model Predictive Control of Buoy Type Wave Energy Converter

    DEFF Research Database (Denmark)

    Soltani, Mohsen N.; Sichani, Mahdi T.; Mirzaei, Mahmood

    2014-01-01

    by forcing this condition. In the paper the theoretical framework for this principal is shown. The optimal controller requires information of the sea state for infinite horizon which is not applicable. Model Predictive Controllers (MPC) can have finite horizon which crosses out this requirement....... This approach is then taken into account and an MPC controller is designed for a model wave energy converter and implemented on a numerical example. Further, the power outtake of this controller is compared to the optimal controller as an indicator of the performance of the designed controller....

  18. Rich dynamics of a food chain model with ratio-dependent type III ...

    African Journals Online (AJOL)

    Rich dynamics of a food chain model with ratio-dependent type III functional responses. ... Stability analysis of model is carried out by using usual theory of ordinary ... that Hopf bifurcation may also occur when delay passes its critical value.

  19. Modeling and experimental study of a corrugated wick type solar still: Comparative study with a simple basin type

    International Nuclear Information System (INIS)

    Matrawy, K.K.; Alosaimy, A.S.; Mahrous, A.-F.

    2015-01-01

    Highlights: • Performance of corrugated wick type solar still is compared with simple type. • Corrugated porous surface contributes by about 75% of the total productivity. • Productivity of corrugated solar still was 34% more than that for simple type. - Abstract: In the present work, the productivity of a solar still is modified by forming the evaporative surface as a corrugated shape as well as by decreasing the heat capacity with the use of a porous material. This target has been achieved by using black clothes in a corrugated shape that are immersed in water where the clothes absorbs water and get saturated by capillary effect. Along with the proposed corrugated wick type solar still, a simple basin still type was fabricated and tested to compare the enhancement accomplished by the developed solar still. Inclined reflectors were used to augment the solar radiation incident on the plane of the developed solar stills. The energy balance in the developed mathematical models takes into consideration the glass covers, the porous material, along with the portion of water exposed to the transmitted solar radiation as well as the portion of water shaded by the corrugated surface. The developed mathematical model was validated by fabricating and testing two models for the proposed and simple basin solar stills under the same conditions. Good agreement between the simulated and experimental results has been detected. It has been found that an improvement of about 34% in the productivity for the proposed wick type solar still is gained as compared to the simple basin case. Also, the best tilt angle for the inclined reflector has been found to be about 30° with respect to the vertical direction of the setup under consideration.

  20. Robust model identification applied to type 1diabetes

    DEFF Research Database (Denmark)

    Finan, Daniel Aaron; Jørgensen, John Bagterp; Poulsen, Niels Kjølstad

    2010-01-01

    In many realistic applications, process noise is known to be neither white nor normally distributed. When identifying models in these cases, it may be more effective to minimize a different penalty function than the standard sum of squared errors (as in a least-squares identification method). Thi...

  1. An Overview of Rainfall-Runoff Model Types

    Science.gov (United States)

    This report explores rainfall-runoff models, their generation methods, and the categories under which they fall. Runoff plays an important role in the hydrological cycle by returning excess precipitation to the oceans and controlling how much water flows into stream systems. Mode...

  2. Bianchi Type-II inflationary models with constant deceleration ...

    Indian Academy of Sciences (India)

    ginning of the 1980s, nowadays receives a great deal of attention. Guth [1] proposed inflationary model in the context of grand unified theory (GUT), which has been accepted soon as the ..... where m1(> 0) is a constant of integration and n = 3. .... interesting feature of the present solution is that it is possible to exit from expo-.

  3. Modelling axisymmetric cod-ends made of different mesh types

    DEFF Research Database (Denmark)

    Priour, D.; Herrmann, Bent; O'Neill, F.G.

    2009-01-01

    the selectivity process has become more important. This paper presents a model of the deformation of an axisymmetric cod-end. The twine tension and the catch pressure acting on the knots of each mesh along the cod-end profile are calculated, and a Newton-Raphson scheme is used to estimate the equilibrium position...

  4. Spectra of Anderson type models with decaying randomness

    Indian Academy of Sciences (India)

    Springer Verlag Heidelberg #4 2048 1996 Dec 15 10:16:45

    Our models include potentials decaying in all directions in which case ..... the free operators with some uniform bounds of low moments of the measure µ weighted ..... We have the following inequality coming out of Cauchy–Schwarz and Fubini, ... The required statement on the limit follows if we now show that the quantity in ...

  5. Efficient Beam-Type Structural Modeling of Rotor Blades

    DEFF Research Database (Denmark)

    Couturier, Philippe; Krenk, Steen

    2015-01-01

    The present paper presents two recently developed numerical formulations which enable accurate representation of the static and dynamic behaviour of wind turbine rotor blades using little modeling and computational effort. The first development consists of an intuitive method to extract fully...... by application to a composite section with bend-twist coupling and a real wind turbine blade....

  6. Volumetric PIV behind mangrove-type root models

    Science.gov (United States)

    Kazemi, Amirkhosro; van de Riet, Keith; Curet, Oscar M.

    2017-11-01

    Mangrove trees form dense networks of prop roots in coastal intertidal zones. The interaction of mangroves with the tidal flow is fundamental in estuaries and shoreline by providing water filtration, protection against erosion and habitat for aquatic animals. In this work, we modeled the mangrove prop roots with a cluster of rigid circular cylinders (patch) to investigate its hydrodynamics. We conducted 2-D PIV and V3V in the near- and far-wake in the recirculating water channel. Two models were considered: (1) a rigid patch, and (2) a flexible patch modeled as rigid cylinders with a flexible hinge. We found that Strouhal number changes with porosity while the patch diameter is constant. Based on the wake signature, we defined an effective diameter length scale. The volumetric flow measurements revealed a regular shedding forming von Kármán vortices for the rigid patch while the flexible patch produced a less uniform wake where vortices were substantially distorted. We compare the wake structure between that 2-D PIV and V3V. This analysis of the hydrodynamics of mangrove-root like models can also be extended to understand other complex flows including bio-inspired coastal infrastructures, damping-wave systems, and energy harvesting devices.

  7. Adaptation of Sing Lee's model to the Filippov type plasma focus geometry

    International Nuclear Information System (INIS)

    Siahpoush, V; Tafreshi, M A; Sobhanian, S; Khorram, S

    2005-01-01

    A new model for plasma behaviour in Filippov type plasma focus (PF) systems has been described and used. This model is based on the so-called slug model and Sing Lee's model for Mather type PF devices. Using the model, the discharge current and its derivative as a function of time, and the pinch time and the maximum discharge current as a function of pressure, have been predicted. At the end, the predicted data are compared with the experimental data obtained through a Filippov type PF facility with a nominal maximum energy of 90 kJ

  8. Velocity potential formulations of highly accurate Boussinesq-type models

    DEFF Research Database (Denmark)

    Bingham, Harry B.; Madsen, Per A.; Fuhrman, David R.

    2009-01-01

    , B., 2006. A Boussinesq-type method for fully nonlinear waves interacting with a rapidly varying bathymetry. Coast. Eng. 53, 487-504); Jamois et al. (Jamois, E., Fuhrman, D.R., Bingham, H.B., Molin, B., 2006. Wave-structure interactions and nonlinear wave processes on the weather side of reflective...... with the kinematic bottom boundary condition. The true behaviour of the velocity potential formulation with respect to linear shoaling is given for the first time, correcting errors made by Jamois et al. (Jamois, E., Fuhrman, D.R., Bingham, H.B., Molin, B., 2006. Wave-structure interactions and nonlinear wave...... processes on the weather side of reflective structures. Coast. Eng. 53, 929-945). An exact infinite series solution for the potential is obtained via a Taylor expansion about an arbitrary vertical position z=(z) over cap. For practical implementation however, the solution is expanded based on a slow...

  9. Sv-map between type I and heterotic sigma models

    Science.gov (United States)

    Fan, Wei; Fotopoulos, A.; Stieberger, S.; Taylor, T. R.

    2018-05-01

    The scattering amplitudes of gauge bosons in heterotic and open superstring theories are related by the single-valued projection which yields heterotic amplitudes by selecting a subset of multiple zeta value coefficients in the α‧ (string tension parameter) expansion of open string amplitudes. In the present work, we argue that this relation holds also at the level of low-energy expansions (or individual Feynman diagrams) of the respective effective actions, by investigating the beta functions of two-dimensional sigma models describing world-sheets of open and heterotic strings. We analyze the sigma model Feynman diagrams generating identical effective action terms in both theories and show that the heterotic coefficients are given by the single-valued projection of the open ones. The single-valued projection appears as a result of summing over all radial orderings of heterotic vertices on the complex plane representing string world-sheet.

  10. Using suggestion to model different types of automatic writing.

    Science.gov (United States)

    Walsh, E; Mehta, M A; Oakley, D A; Guilmette, D N; Gabay, A; Halligan, P W; Deeley, Q

    2014-05-01

    Our sense of self includes awareness of our thoughts and movements, and our control over them. This feeling can be altered or lost in neuropsychiatric disorders as well as in phenomena such as "automatic writing" whereby writing is attributed to an external source. Here, we employed suggestion in highly hypnotically suggestible participants to model various experiences of automatic writing during a sentence completion task. Results showed that the induction of hypnosis, without additional suggestion, was associated with a small but significant reduction of control, ownership, and awareness for writing. Targeted suggestions produced a double dissociation between thought and movement components of writing, for both feelings of control and ownership, and additionally, reduced awareness of writing. Overall, suggestion produced selective alterations in the control, ownership, and awareness of thought and motor components of writing, thus enabling key aspects of automatic writing, observed across different clinical and cultural settings, to be modelled. Copyright © 2014. Published by Elsevier Inc.

  11. Emergent behaviour of a generalized Viscek-type flocking model

    International Nuclear Information System (INIS)

    Ha, Seung-Yeal; Jeong, Eunhee; Kang, Moon-Jin

    2010-01-01

    We present a planar agent-based flocking model with a distance-dependent communication weight. We derive a sufficient condition for the asymptotic flocking in terms of the initial spatial and heading-angle diameters and a communication weight. For this, we employ differential inequalities for the spatial and phase diameters together with the Lyapunov functional approach. When the diameter of the agent's initial heading-angles is sufficiently small, we show that the diameter of the heading-angles converges to the average value of the initial heading-angles exponentially fast. As an application of flocking estimates, we also show that the Kuramoto model with a connected communication topology on the regular lattice Z d for identical oscillators exhibits a complete-phase-frequency synchronization, when coupled oscillators are initially distributed on the half circle

  12. Nonlinear Dynamic Modeling of Langevin-Type Piezoelectric Transducers

    Directory of Open Access Journals (Sweden)

    Nicolás Peréz Alvarez

    2015-11-01

    Full Text Available Langevin transducers are employed in several applications, such as power ultrasound systems, naval hydrophones, and high-displacement actuators. Nonlinear effects can influence their performance, especially at high vibration amplitude levels. These nonlinear effects produce variations in the resonant frequency, harmonics of the excitation frequency, in addition to loss of symmetry in the frequency response and “frequency domain hysteresis”. In this context, this paper presents a simplified nonlinear dynamic model of power ultrasound transducers requiring only two parameters for simulating the most relevant nonlinear effects. One parameter reproduces the changes in the resonance frequency and the other introduces the dependence of the frequency response on the history of the system. The piezoelectric constitutive equations are extended by a linear dependence of the elastic constant on the mechanical displacement amplitude. For introducing the frequency hysteresis, the elastic constant is computed by combining the current value of the mechanical amplitude with the previous state amplitude. The model developed in this work is applied for predicting the dynamic responses of a 26 kHz ultrasonic transducer. The comparison of theoretical and experimental responses, obtained at several input voltages around the tuned frequency, shows a good agreement, indicating that the model can accurately describe the transducer nonlinear behavior.

  13. Tilted Bianchi type I dust fluid cosmological model in general relativity

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 58; Issue 3. Tilted Bianchi type I dust fluid cosmological model in general ... In this paper, we have investigated a tilted Bianchi type I cosmological model filled with dust of perfect fluid in general relativity. To get a determinate solution, we have assumed a condition  ...

  14. Tilted Bianchi type I dust fluid cosmological model in general relativity

    Indian Academy of Sciences (India)

    Tilted Bianchi type I dust fluid cosmological model in general relativity ... In this paper, we have investigated a tilted Bianchi type I cosmological model filled with dust of perfect fluid in general relativity. ... Pramana – Journal of Physics | News ...

  15. Desensitization and Modeling Treatments of Spider Fear Using Two Types of Scenes

    Science.gov (United States)

    Denney, Douglas R.; Sullivan, Bernard J.

    1976-01-01

    Three types of therapy were combined with two types of scenes. Spider-phobic subjects were assigned to one of the six treatment conditions or to an untreated control group. In general, (a) Desensitization and modeling therapies were equally effective; (b) modeling alone was more effective than mere exposure to the phobic object. (Author)

  16. Desafios na era pós genômica para o desenvolvimento de testes laboratoriais para o diagnóstico da hanseníase Challenges in the post genomic era for the development of tests for leprosy diagnosis

    Directory of Open Access Journals (Sweden)

    Mariane Martins de Araújo Stefani

    2008-01-01

    Full Text Available O diagnóstico da hanseníase se baseia em manifestações clínicas e não existe teste laboratorial para diagnosticar casos assintomáticos ou para prever progressão da doença entre indivíduos expostos. Novas análises genômicas comparativas in silico e ferramentas de biologia molecular têm sido empregadas para revelar proteínas exclusivas do Mycobacterium leprae que apresentem potencial aplicação diagnóstica. A hanseníase tuberculóide paucibacilar (PB apresenta baixo nível de anticorpos e forte resposta imune celular (RIC tipo Th1/interferon gamma (IFN-γ. A doença lepromatosa multibacilar (MB apresenta sorologia positiva e fraca RIC. Portanto, testes laboratoriais para diagnosticar hanseníase PB e MB devem contemplar testes de RIC e sorologia. Proteínas recombinantes do Mycobacterium leprae sorologicamente reativas podem ser incorporadas ao antígeno PGLI para melhorar o diagnóstico sorológico de pacientes MB. Proteínas recombinantes e peptídeos sintéticos do Mycobacterium leprae têm sido testados em ensaios de RIC/IFN-γ para diagnosticar casos PB. Sorologia anti-PGLI modificada incorporando novos antígenos do Mycobacterium leprae e ensaios baseados na RIC/produção de IFN-γ devem permitir a detecção precoce de casos MB e PB em países endêmicos.Leprosy diagnosis is based mainly on clinical manifestations and no laboratory test is available to diagnose asymptomatic disease or to predict disease progression among exposed individuals. Novel comparative genomic in silico analyses and molecular biology tools have discovered unique Mycobacterium leprae proteins with potential diagnostic application. Tuberculoid paucibacillary leprosy (PB shows low antibodies titers and strong Th1 type/ IFN-γ specific cell mediated immunity (CMI, while lepromatous multibacillary patients (MB show high antibody titers and low CMI. Therefore, laboratory tests for PB and MB leprosy diagnosis will require CMI and antibody based assays

  17. Complex Dynamics of an Adnascent-Type Game Model

    Directory of Open Access Journals (Sweden)

    Baogui Xin

    2008-01-01

    Full Text Available The paper presents a nonlinear discrete game model for two oligopolistic firms whose products are adnascent. (In biology, the term adnascent has only one sense, “growing to or on something else,” e.g., “moss is an adnascent plant.” See Webster's Revised Unabridged Dictionary published in 1913 by C. & G. Merriam Co., edited by Noah Porter. The bifurcation of its Nash equilibrium is analyzed with Schwarzian derivative and normal form theory. Its complex dynamics is demonstrated by means of the largest Lyapunov exponents, fractal dimensions, bifurcation diagrams, and phase portraits. At last, bifurcation and chaos anticontrol of this system are studied.

  18. A modified Ozer-Taha type cosmological model

    Science.gov (United States)

    John, Moncy V.; Joseph, K. Babu

    1996-02-01

    A modified version of the Ozer and Taha nonsingular cosmological model is presented on the assumption that the universe's radius is complex if it is regarded as empty, but it contains matter when the radius is real. It also predicts the values: ΩM --- ρM/(ρC) ≈ 4/(3), ΩV --- ρV/(ρC) ≈ 2/(3) and Ω- --- ρ-/(ρC) ≪ 1 in the present nonrelativistic era, where ρM = matter density, ρV = vacuum energy density, ρ- = negative energy density and ρC = critical density.

  19. Godunov-type schemes for hydrodynamic and magnetohydrodynamic modeling

    International Nuclear Information System (INIS)

    Vides-Higueros, Jeaniffer

    2014-01-01

    The main objective of this thesis concerns the study, design and numerical implementation of finite volume schemes based on the so-Called Godunov-Type solvers for hyperbolic systems of nonlinear conservation laws, with special attention given to the Euler equations and ideal MHD equations. First, we derive a simple and genuinely two-Dimensional Riemann solver for general conservation laws that can be regarded as an actual 2D generalization of the HLL approach, relying heavily on the consistency with the integral formulation and on the proper use of Rankine-Hugoniot relations to yield expressions that are simple enough to be applied in the structured and unstructured contexts. Then, a comparison between two methods aiming to numerically maintain the divergence constraint of the magnetic field for the ideal MHD equations is performed and we show how the 2D Riemann solver can be employed to obtain robust divergence-Free simulations. Next, we derive a relaxation scheme that incorporates gravity source terms derived from a potential into the hydrodynamic equations, an important problem in astrophysics, and finally, we review the design of finite volume approximations in curvilinear coordinates, providing a fresher view on an alternative discretization approach. Throughout this thesis, numerous numerical results are shown. (author) [fr

  20. Types of distribution of electric fields and the types of convection corresponding to them in the polar ionosphere. A model.

    Science.gov (United States)

    Uvarov, V. M.; Barashkov, P. D.

    1989-06-01

    All types of distributions known from experiment of the evening-morning component of the electric field Ee-m along the morning-evening meridian are reproduced on the basis of a model of the continuous distribution of largescale electric fields E, and the convection patterns corresponding to them, which differ appreciably from the known speculative concepts, are calculated. Two-, three-, and four-vortex convection patterns are realized, depending on the conditions in the interplanetary medium.

  1. Types of electric-field distribution and corresponding types of convection in the polar ionosphere - A model

    Science.gov (United States)

    Uvarov, V. M.; Barashkov, P. D.

    1989-08-01

    A model for the continuous distribution of large-scale electric fields is used to reproduce all the experimentally known types of distributions of the evening-morning electric field component along the morning-evening meridian. The corresponding convection patterns are then calculated, which are shown to diverge significantly from previous theoretical considerations. Depending on conditions in the interplanetary medium, two-, three-, or four-vortex convection patterns occur.

  2. Genetic modelling in schizophrenia according to HLA typing.

    Science.gov (United States)

    Smeraldi, E; Macciardi, F; Gasperini, M; Orsini, A; Bellodi, L; Fabio, G; Morabito, A

    1986-09-01

    Studying families of schizophrenic patients, we observed that the risk of developing the overt form of the illness could be enhanced by some factors. Among these various factors we focused our attention on a biological variable, namely the presence or the absence of particular HLA antigens: partitioning our schizophrenic patients according to their HLA structure (i.e. those with HLA-A1 or CRAG-A1 antigens and those with HLA-non-CRAG-A1 antigens, respectively), revealed different illness distribution in the two groups. From a genetic point of view, this finding suggests the presence of heterogeneity in the hypothetical liability system related to schizophrenia and we evaluated the heterogeneity hypothesis by applying alternative genetic models to our data, trying to detect more biologically homogeneous subgroups of the disease.

  3. A bivariate model for analyzing recurrent multi-type automobile failures

    Science.gov (United States)

    Sunethra, A. A.; Sooriyarachchi, M. R.

    2017-09-01

    The failure mechanism in an automobile can be defined as a system of multi-type recurrent failures where failures can occur due to various multi-type failure modes and these failures are repetitive such that more than one failure can occur from each failure mode. In analysing such automobile failures, both the time and type of the failure serve as response variables. However, these two response variables are highly correlated with each other since the timing of failures has an association with the mode of the failure. When there are more than one correlated response variables, the fitting of a multivariate model is more preferable than separate univariate models. Therefore, a bivariate model of time and type of failure becomes appealing for such automobile failure data. When there are multiple failure observations pertaining to a single automobile, such data cannot be treated as independent data because failure instances of a single automobile are correlated with each other while failures among different automobiles can be treated as independent. Therefore, this study proposes a bivariate model consisting time and type of failure as responses adjusted for correlated data. The proposed model was formulated following the approaches of shared parameter models and random effects models for joining the responses and for representing the correlated data respectively. The proposed model is applied to a sample of automobile failures with three types of failure modes and up to five failure recurrences. The parametric distributions that were suitable for the two responses of time to failure and type of failure were Weibull distribution and multinomial distribution respectively. The proposed bivariate model was programmed in SAS Procedure Proc NLMIXED by user programming appropriate likelihood functions. The performance of the bivariate model was compared with separate univariate models fitted for the two responses and it was identified that better performance is secured by

  4. Electrophysiological characterization of spinal neurons in different models of diabetes type 1- and type 2-induced neuropathy in rats.

    Science.gov (United States)

    Schuelert, N; Gorodetskaya, N; Just, S; Doods, H; Corradini, L

    2015-04-16

    Diabetic polyneuropathy (DPN) is a devastating complication of diabetes. The underlying pathogenesis of DPN is still elusive and an effective treatment devoid of side effects presents a challenge. There is evidence that in type-1 and -2 diabetes, metabolic and morphological changes lead to peripheral nerve damage and altered central nociceptive transmission, which may contribute to neuropathic pain symptoms. We characterized the electrophysiological response properties of spinal wide dynamic range (WDR) neurons in three diabetic models. The streptozotocin (STZ) model was used as a drug-induced model of type-1 diabetes, and the BioBreeding/Worcester (BB/Wor) and Zucker diabetic fatty (ZDF) rat models were used for genetic DPN models. Data were compared to the respective control group (BB/Wor diabetic-resistant, Zucker lean (ZL) and saline-injected Wistar rat). Response properties of WDR neurons to mechanical stimulation and spontaneous activity were assessed. We found abnormal response properties of spinal WDR neurons in all diabetic rats but not controls. Profound differences between models were observed. In BB/Wor diabetic rats evoked responses were increased, while in ZDF rats spontaneous activity was increased and in STZ rats mainly after discharges were increased. The abnormal response properties of neurons might indicate differential pathological, diabetes-induced, changes in spinal neuronal transmission. This study shows for the first time that specific electrophysiological response properties are characteristic for certain models of DPN and that these might reflect the diverse and complex symptomatology of DPN in the clinic. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

  5. Impact of Diabetes Education Based on Type 1 Diabetes management model

    OpenAIRE

    Ocakçı, Ayşe Ferda

    2015-01-01

    The diabetes management is considered to be adversely affected when adolescent-specific education methods are not used. In this study, Type 1 Diabetes Management Model which ensures standardisation of the diabetes education and is based on the health promotion model and formed by applying health promotion model (HPM) according to the mastery-learning theory was used. The study was performed to determine effectiveness of diabetes education based on “Type 1 Diabetes Management Model” on adolesc...

  6. Study of physiological properties of some probiotics in multiple cultures with mesophilic lactic acid bacteria by Flora Danica Ch. Hansen commercial starter

    Directory of Open Access Journals (Sweden)

    DANIELA PARASCHIV

    2011-12-01

    Full Text Available The aim of this study was to establish the growth ability and stability of probiotic strains Lactobacillus acidophilus (commercial code La-5®, Lactobacillus casei ssp. paracasei (commercial code L. casei 431® and Bifidobacterium bifidus (commercial code BB-12® in multiple cultures with mesophilic lactic bacteria, Lactococcus lactis ssp. cremoris, Lactococcus lactis ssp. lactis, Lactococcus lactis ssp. diacetylactis and Leuconostoc mesenteroides spp. cremoris, as Flora Danica Chr. Hansen commercial starters. Under the controlled fermentative conditions described below, a good starter combination, for the high rate of cells multiplication and for the good viability during storage, was identified in the mixture of L. casei 431®, BB-12® and Flora Danica, in ratio of 1:1:1 (9 log CFU/mL for each starter culture.

  7. Hanseníase: a implicação da educação em saúde para o autocuidado

    OpenAIRE

    Duarte, Lucelia Maria Carla Paulo da Silva

    2014-01-01

    A hanseníase é um problema de saúde em nível mundial devido principalmente ao seu potencial incapacitante. A estratégia de combate à doença adotada pelo Ministério de Saúde é o diagnóstico e tratamento precoces, prevenção e tratamento de incapacidades físicas e vigilância dos contatos domiciliares. Tudo isso fundamentado na educação em saúde como sustentáculo para compreensão do processo de adoecimento, da doença em si, sua aceitação e, principalmente, das ações de autocuidado para prevenção ...

  8. Image Restoration Based on the Hybrid Total-Variation-Type Model

    OpenAIRE

    Shi, Baoli; Pang, Zhi-Feng; Yang, Yu-Fei

    2012-01-01

    We propose a hybrid total-variation-type model for the image restoration problem based on combining advantages of the ROF model with the LLT model. Since two ${L}^{1}$ -norm terms in the proposed model make it difficultly solved by using some classically numerical methods directly, we first employ the alternating direction method of multipliers (ADMM) to solve a general form of the proposed model. Then, based on the ADMM and the Moreau-Yosida decomposition theory, a more efficient method call...

  9. Matérn's hard core models of types I and II with arbitrary compact grains

    DEFF Research Database (Denmark)

    Kiderlen, Markus; Hörig, Mario

    Matérn's classical hard core models can be interpreted as models obtained from a stationary marked Poisson process by dependent thinning. The marks are balls of fixed radius, and a point is retained when its associated ball does not hit any other balls (type I) or when its random birth time is st...... of this model with the process of intact grains of the dead leaves model and the Stienen model leads to analogous results for the latter....

  10. Multivariate poisson lognormal modeling of crashes by type and severity on rural two lane highways.

    Science.gov (United States)

    Wang, Kai; Ivan, John N; Ravishanker, Nalini; Jackson, Eric

    2017-02-01

    In an effort to improve traffic safety, there has been considerable interest in estimating crash prediction models and identifying factors contributing to crashes. To account for crash frequency variations among crash types and severities, crash prediction models have been estimated by type and severity. The univariate crash count models have been used by researchers to estimate crashes by crash type or severity, in which the crash counts by type or severity are assumed to be independent of one another and modelled separately. When considering crash types and severities simultaneously, this may neglect the potential correlations between crash counts due to the presence of shared unobserved factors across crash types or severities for a specific roadway intersection or segment, and might lead to biased parameter estimation and reduce model accuracy. The focus on this study is to estimate crashes by both crash type and crash severity using the Integrated Nested Laplace Approximation (INLA) Multivariate Poisson Lognormal (MVPLN) model, and identify the different effects of contributing factors on different crash type and severity counts on rural two-lane highways. The INLA MVPLN model can simultaneously model crash counts by crash type and crash severity by accounting for the potential correlations among them and significantly decreases the computational time compared with a fully Bayesian fitting of the MVPLN model using Markov Chain Monte Carlo (MCMC) method. This paper describes estimation of MVPLN models for three-way stop controlled (3ST) intersections, four-way stop controlled (4ST) intersections, four-way signalized (4SG) intersections, and roadway segments on rural two-lane highways. Annual Average Daily traffic (AADT) and variables describing roadway conditions (including presence of lighting, presence of left-turn/right-turn lane, lane width and shoulder width) were used as predictors. A Univariate Poisson Lognormal (UPLN) was estimated by crash type and

  11. 76 FR 62605 - Airworthiness Directives; Viking Air Limited Model DHC-3 (Otter) Airplanes With Supplemental Type...

    Science.gov (United States)

    2011-10-11

    ... Airworthiness Directives; Viking Air Limited Model DHC-3 (Otter) Airplanes With Supplemental Type Certificate.... That AD applies to Viking Air Limited Model DHC-3 (Otter) airplanes equipped with a Honeywell TPE331... limitations and marking the airspeed indicator accordingly for Viking Air Limited Model DHC-3 (Otter...

  12. A Linear Programming Model to Optimize Various Objective Functions of a Foundation Type State Support Program.

    Science.gov (United States)

    Matzke, Orville R.

    The purpose of this study was to formulate a linear programming model to simulate a foundation type support program and to apply this model to a state support program for the public elementary and secondary school districts in the State of Iowa. The model was successful in producing optimal solutions to five objective functions proposed for…

  13. Model tests and elasto-plastic finite element analysis on multicavity type PCRV

    International Nuclear Information System (INIS)

    Nojiri, Y.; Yamazaki, M.; Kotani, K.; Matsuzaki, Y.

    1978-01-01

    Multicavity type PCRV models were tested to investigate elastic stress distributions, cracking and failure mode of the models, and to determine the adequacy and relative accuracy of finite element structural analyses. The behavior of the models under pressure was investigated, and it was found that the predictions of the analyses showed a good agreement with the test results

  14. Modeling neuropeptide transport in various types of nerve terminals containing en passant boutons.

    Science.gov (United States)

    Kuznetsov, I A; Kuznetsov, A V

    2015-03-01

    We developed a mathematical model for simulating neuropeptide transport inside dense core vesicles (DCVs) in axon terminals containing en passant boutons. The motivation for this research is a recent experimental study by Levitan and colleagues (Bulgari et al., 2014) which described DCV transport in nerve terminals of type Ib and type III as well as in nerve terminals of type Ib with the transcription factor DIMM. The goal of our modeling is validating the proposition put forward by Levitan and colleagues that the dramatic difference in DCV number in type Ib and type III terminals can be explained by the difference in DCV capture in type Ib and type III boutons rather than by differences in DCV anterograde transport and half-life of resident DCVs. The developed model provides a tool for studying the dynamics of DCV transport in various types of nerve terminals. The model is also an important step in gaining a better mechanistic understanding of transport processes in axons and identifying directions for the development of new models in this area. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. Stochastic analysis of a pulse-type prey-predator model

    Science.gov (United States)

    Wu, Y.; Zhu, W. Q.

    2008-04-01

    A stochastic Lotka-Volterra model, a so-called pulse-type model, for the interaction between two species and their random natural environment is investigated. The effect of a random environment is modeled as random pulse trains in the birth rate of the prey and the death rate of the predator. The generalized cell mapping method is applied to calculate the probability distributions of the species populations at a state of statistical quasistationarity. The time evolution of the population densities is studied, and the probability of the near extinction time, from an initial state to a critical state, is obtained. The effects on the ecosystem behaviors of the prey self-competition term and of the pulse mean arrival rate are also discussed. Our results indicate that the proposed pulse-type model shows obviously distinguishable characteristics from a Gaussian-type model, and may confer a significant advantage for modeling the prey-predator system under discrete environmental fluctuations.

  16. Algebraic Specifications, Higher-order Types and Set-theoretic Models

    DEFF Research Database (Denmark)

    Kirchner, Hélène; Mosses, Peter David

    2001-01-01

    , and power-sets. This paper presents a simple framework for algebraic specifications with higher-order types and set-theoretic models. It may be regarded as the basis for a Horn-clause approximation to the Z framework, and has the advantage of being amenable to prototyping and automated reasoning. Standard......In most algebraic  specification frameworks, the type system is restricted to sorts, subsorts, and first-order function types. This is in marked contrast to the so-called model-oriented frameworks, which provide higer-order types, interpreted set-theoretically as Cartesian products, function spaces...... set-theoretic models are considered, and conditions are given for the existence of initial reduct's of such models. Algebraic specifications for various set-theoretic concepts are considered....

  17. A comprehensive compartmental model of blood glucose regulation for healthy and type 2 diabetic subjects

    DEFF Research Database (Denmark)

    Vahidi, O; Kwok, K E; Gopaluni, R B

    2016-01-01

    We have expanded a former compartmental model of blood glucose regulation for healthy and type 2 diabetic subjects. The former model was a detailed physiological model which considered the interactions of three substances, glucose, insulin and glucagon on regulating the blood sugar. The main...... variations of blood glucose concentrations following an oral glucose intake. Another model representing the incretins production in the gastrointestinal tract along with their hormonal effects on boosting pancreatic insulin production is also added to the former model. We have used two sets of clinical data...... obtained during oral glucose tolerance test and isoglycemic intravenous glucose infusion test from both type 2 diabetic and healthy subjects to estimate the model parameters and to validate the model results. The estimation of model parameters is accomplished through solving a nonlinear optimization...

  18. Applying the Transtheoretical Model to Investigate Behavioural Change in Type 2 Diabetic Patients

    Science.gov (United States)

    Lin, Shu-Ping; Wang, Ming-Jye

    2013-01-01

    Background: Long-term behaviour change in type 2 diabetic patients may provide effective glycemic control. Purpose: To investigate the key factors that promote behaviour change in diabetic subjects using the transtheoretical model. Methods: Subjects were selected by purposive sampling from type 2 diabetes outpatients. Self-administered…

  19. Analysis and synthesis for interval type-2 fuzzy-model-based systems

    CERN Document Server

    Li, Hongyi; Lam, Hak-Keung; Gao, Yabin

    2016-01-01

    This book develops a set of reference methods capable of modeling uncertainties existing in membership functions, and analyzing and synthesizing the interval type-2 fuzzy systems with desired performances. It also provides numerous simulation results for various examples, which fill certain gaps in this area of research and may serve as benchmark solutions for the readers. Interval type-2 T-S fuzzy models provide a convenient and flexible method for analysis and synthesis of complex nonlinear systems with uncertainties.

  20. MODELS OF AN-TYPE INNOVATIVE ENDOGENOUS GROWTH AND THEIR SUBSTANTIATION

    Directory of Open Access Journals (Sweden)

    Askar A. Akaev

    2015-01-01

    Full Text Available The article presents an analysis of some classical models of economic growth of exogenous and endogenous type, based on the calculation of the motion of physical capital. It is shown that the simplest AN-type model, based on the calculation of population dynamics and endogenous technological progress, is more adequate for the description of the current economic development and provides a more accurate long-term forecast of economic dynamics.

  1. A study on modelling of a butterfly-type control valve by a pneumatic actuator

    International Nuclear Information System (INIS)

    Hwang, I Cheol; Park, Cheol Jae

    2009-01-01

    This paper studies on the modelling of a butterfly-type control valve actuating by an on-off pneumatic solenoid valve. The mathematical model is composed of nonlinear differential equations three parts: (i) a solenoid valve, (ii) a pneumatic cylinder, (iii) a rotary-type butterfly valve. The flow characteristics of the butterfly control valve is analysed by a computer simulator, then its simple transfer function is identified from the step responses.

  2. Nonlinear punctual dynamic applied to simulation of PWR type reactors

    International Nuclear Information System (INIS)

    Cysne, F.S.

    1978-01-01

    In order to study some kinds of nuclear reactor accidents, a simulation is made using the punctual kinetics model to the reactor core. The following integration methods are used: Hansen's method in which a linearization is made and C S M P using a variable interval fourth-order Runge Kutta method. The results were good and were compared with those obtained by the code Dinamica I which uses a finite difference integration method of backward kind. (author)

  3. Some five-dimensional Bianchi type-iii string cosmological models in general relativity

    International Nuclear Information System (INIS)

    Samanta, G.C.; Biswal, S.K.; Mohanty, G.; Rameswarpatna, Bhubaneswar

    2011-01-01

    In this paper we have constructed some five-dimensional Bianchi type-III cosmological models in general relativity when source of gravitational field is a massive string. We obtained different classes of solutions by considering different functional forms of metric potentials. It is also observed that one of the models is not physically acceptable and the other models possess big-bang singularity. The physical and kinematical behaviors of the models are discussed

  4. Representações sociais e hanseníase em São Domingos do Capim: um estudo de caso na Amazônia Social representations and hansen's disease in São Domingos do Capim, state of Pará: a study in brazilian Amazon

    Directory of Open Access Journals (Sweden)

    Anete Umbelina Ferreira de Almeida Lins

    2010-01-01

    Full Text Available Este estudo analisa as representações sociais da hanseníase em São Domingos do Capim-PA, a partir da perspectiva da antropologia da doença. As representações são compreendidas como estruturas dinâmicas socialmente construídas que fundamentam as ações dos sujeitos e dos grupos na resolução dos episódios de doença e na produção de sentido para as experiências de adoecimento. Para compreender a lógica das interpretações da doença, foram reconstituídos os itinerários terapêuticos dos doentes, a partir de dados coletados na observação de campo, realizada ao longo de quatro anos, e entrevistas narrativas com doentes, familiares e agentes comunitários de saúde. Foram deduzidas quatro categorias nosológicas êmicas referentes aos sintomas da hanseníase - "manchas", "lepra", "feitiço" e "hanseníase" -, que constituem o repertório a partir do qual as interpretações e práticas são formuladas. O uso das diferentes categorias ocorre segundo esquemas locais que permitem a avaliação dos contextos pessoal e social de irrupção da doença numa dinâmica que articula as percepções do doente e de seus familiares, as interpretações e diagnósticos de curadores tradicionais e a abordagem dos profissionais da Biomedicina. O estudo mostra que o repertório interpretativo e os meios terapêuticos da Biomedicina são reinterpretados, pelos doentes, segundo a lógica das representações e das práticas locais de saúde, e que o controle da endemia hansênica pressupõe a compreensão das dinâmicas sociais implicadas nas interpretações e práticas da doença, de forma a possibilitar o estabelecimento de uma relação dialógica entre os profissionais de saúde e os atores locais.This study analyzes the social representations of Hansen's disease in São Domingos do Capim-PA, from the perspective of the anthropology of disease. The representations are understood as socially constructed dynamic structures that underlie the

  5. Testing Affine Term Structure Models in Case of Transaction Costs

    NARCIS (Netherlands)

    Driessen, J.J.A.G.; Melenberg, B.; Nijman, T.E.

    1999-01-01

    In this paper we empirically analyze the impact of transaction costs on the performance of affine interest rate models. We test the implied (no arbitrage) Euler restrictions, and we calculate the specification error bound of Hansen and Jagannathan to measure the extent to which a model is

  6. A manufacturing quality assessment model based-on two stages interval type-2 fuzzy logic

    Science.gov (United States)

    Purnomo, Muhammad Ridwan Andi; Helmi Shintya Dewi, Intan

    2016-01-01

    This paper presents the development of an assessment models for manufacturing quality using Interval Type-2 Fuzzy Logic (IT2-FL). The proposed model is developed based on one of building block in sustainable supply chain management (SSCM), which is benefit of SCM, and focuses more on quality. The proposed model can be used to predict the quality level of production chain in a company. The quality of production will affect to the quality of product. Practically, quality of production is unique for every type of production system. Hence, experts opinion will play major role in developing the assessment model. The model will become more complicated when the data contains ambiguity and uncertainty. In this study, IT2-FL is used to model the ambiguity and uncertainty. A case study taken from a company in Yogyakarta shows that the proposed manufacturing quality assessment model can work well in determining the quality level of production.

  7. Characterization and modeling of a new magnetorheological damper with meandering type valve using neuro-fuzzy

    Directory of Open Access Journals (Sweden)

    Fitrian Imaduddin

    2017-10-01

    Full Text Available This paper presents the characterization and hysteresis modeling of magnetorheological (MR damper with meandering type valve. The meandering type MR valve, which employs the combination of multiple annular and radial flow passages, has been introduced as the new type of high performance MR valve with higher achievable pressure drop and controllable performance range than similar counterparts in its class. Since the performance of a damper is highly determined by the valve performance, the utilization of the meandering type MR valve in an MR damper could potentially improve the damper performance. The damping force characterization of the MR damper is conducted by measuring the damping force as a response to the variety of harmonic excitations. The hysteresis behavior of the damper is identified by plotting the damping force relationship to the excitation displacement and velocity. For the hysteresis modeling purpose, some parts of the data are taken as the training data source for the optimization parameters in the neuro-fuzzy model. The performance of the trained neuro-fuzzy model is assessed by validating the model output with the remaining measurement data and benchmarking the results with the output of the parametric hysteresis model. The validation results show that the neuro-fuzzy model is demonstrating good agreement with the measurement results indicated by the average relative error of only around 7%. The model also shows robustness with no tendency of growing error when the input values are changed.

  8. Galactic chemical evolution in hierarchical formation models - I. Early-type galaxies in the local Universe

    NARCIS (Netherlands)

    Arrigoni, Matías; Trager, Scott C.; Somerville, Rachel S.; Gibson, Brad K.

    We study the metallicities and abundance ratios of early-type galaxies in cosmological semi-analytic models (SAMs) within the hierarchical galaxy formation paradigm. To achieve this we implemented a detailed galactic chemical evolution model and can now predict abundances of individual elements for

  9. Galactic chemical evolution in hierarchical formation models : I. Early-type galaxies in the local Universe

    NARCIS (Netherlands)

    Arrigoni, Matias; Trager, Scott C.; Somerville, Rachel S.; Gibson, Brad K.

    2010-01-01

    We study the metallicities and abundance ratios of early-type galaxies in cosmological semi-analytic models (SAMs) within the hierarchical galaxy formation paradigm. To achieve this we implemented a detailed galactic chemical evolution model and can now predict abundances of individual elements for

  10. Generalized Path Analysis and Generalized Simultaneous Equations Model for Recursive Systems with Responses of Mixed Types

    Science.gov (United States)

    Tsai, Tien-Lung; Shau, Wen-Yi; Hu, Fu-Chang

    2006-01-01

    This article generalizes linear path analysis (PA) and simultaneous equations models (SiEM) to deal with mixed responses of different types in a recursive or triangular system. An efficient instrumental variable (IV) method for estimating the structural coefficients of a 2-equation partially recursive generalized path analysis (GPA) model and…

  11. Perfect fluid Bianchi Type-I cosmological models with time varying G ...

    Indian Academy of Sciences (India)

    Abstract. Bianchi Type-I cosmological models containing perfect fluid with time vary- ing G and Λ have been presented. The solutions obtained represent an expansion scalar θ bearing a constant ratio to the anisotropy in the direction of space-like unit vector λi. Of the two models obtained, one has negative vacuum energy ...

  12. A simple model to estimate the optimal doping of p - Type oxide superconductors

    Directory of Open Access Journals (Sweden)

    Adir Moysés Luiz

    2008-12-01

    Full Text Available Oxygen doping of superconductors is discussed. Doping high-Tc superconductors with oxygen seems to be more efficient than other doping procedures. Using the assumption of double valence fluctuations, we present a simple model to estimate the optimal doping of p-type oxide superconductors. The experimental values of oxygen content for optimal doping of the most important p-type oxide superconductors can be accounted for adequately using this simple model. We expect that our simple model will encourage further experimental and theoretical researches in superconducting materials.

  13. A comprehensive compartmental model of blood glucose regulation for healthy and type 2 diabetic subjects.

    Science.gov (United States)

    Vahidi, O; Kwok, K E; Gopaluni, R B; Knop, F K

    2016-09-01

    We have expanded a former compartmental model of blood glucose regulation for healthy and type 2 diabetic subjects. The former model was a detailed physiological model which considered the interactions of three substances, glucose, insulin and glucagon on regulating the blood sugar. The main drawback of the former model was its restriction on the route of glucose entrance to the body which was limited to the intravenous glucose injection. To handle the oral glucose intake, we have added a model of glucose absorption in the gastrointestinal tract to the former model to address the resultant variations of blood glucose concentrations following an oral glucose intake. Another model representing the incretins production in the gastrointestinal tract along with their hormonal effects on boosting pancreatic insulin production is also added to the former model. We have used two sets of clinical data obtained during oral glucose tolerance test and isoglycemic intravenous glucose infusion test from both type 2 diabetic and healthy subjects to estimate the model parameters and to validate the model results. The estimation of model parameters is accomplished through solving a nonlinear optimization problem. The results show acceptable precision of the estimated model parameters and demonstrate the capability of the model in accurate prediction of the body response during the clinical studies.

  14. A Study of Enhanced, Higher Order Boussinesq-Type Equations and Their Numerical Modelling

    DEFF Research Database (Denmark)

    Banijamali, Babak

    model is designated for the solution of higher-order Boussinesq-type equations, formulated in terms of the horizontal velocity at an arbitrary depth vector. Various discretisation techniques and grid definitions have been considered in this endeavour, undertaking a detailed analysis of the selected......This project has encompassed efforts in two separate veins: on the one hand, the acquiring of highly accurate model equations of the Boussinesq-type, and on the other hand, the theoretical and practical work in implementing such equations in the form of conventional numerical models, with obvious...... potential for applications to the realm of numerical modelling in coastal engineering. The derivation and analysis of several forms of higher-order in dispersion and non-linearity Boussinesq-type equations have been undertaken, obtaining and investigating the properties of a new and generalised class...

  15. Comparison of renormalization group schemes for sine-Gordon-type models

    International Nuclear Information System (INIS)

    Nandori, I.; Nagy, S.; Sailer, K.; Trombettoni, A.

    2009-01-01

    The scheme dependence of the renormalization group (RG) flow has been investigated in the local potential approximation for two-dimensional periodic, sine-Gordon type field-theoretic models discussing the applicability of various functional RG methods in detail. It was shown that scheme-independent determination of such physical parameters is possible as the critical frequency (temperature) at which Kosterlitz-Thouless-Berezinskii type phase transition takes place in the sine-Gordon and the layered sine-Gordon models, and the critical ratio characterizing the Ising-type phase transition of the massive sine-Gordon model. For the latter case, the Maxwell construction represents a strong constraint on the RG flow, which results in a scheme-independent infrared value for the critical ratio. For the massive sine-Gordon model also the shrinking of the domain of the phase with spontaneously broken periodicity is shown to take place due to the quantum fluctuations.

  16. Input modeling with phase-type distributions and Markov models theory and applications

    CERN Document Server

    Buchholz, Peter; Felko, Iryna

    2014-01-01

    Containing a summary of several recent results on Markov-based input modeling in a coherent notation, this book introduces and compares algorithms for parameter fitting and gives an overview of available software tools in the area. Due to progress made in recent years with respect to new algorithms to generate PH distributions and Markovian arrival processes from measured data, the models outlined are useful alternatives to other distributions or stochastic processes used for input modeling. Graduate students and researchers in applied probability, operations research and computer science along with practitioners using simulation or analytical models for performance analysis and capacity planning will find the unified notation and up-to-date results presented useful. Input modeling is the key step in model based system analysis to adequately describe the load of a system using stochastic models. The goal of input modeling is to find a stochastic model to describe a sequence of measurements from a real system...

  17. Model for Simulating Fasting Glucose in Type 2 Diabetes and the Effect of Adherence to Treatment

    DEFF Research Database (Denmark)

    Aradóttir, Tinna Björk; Boiroux, Dimitri; Bengtsson, Henrik

    2017-01-01

    trial results where a dose guidance algorithm was used. We investigate sources of variance and through simulations evaluate the contribution of adherence to variance and dose guidance quality. The results suggest that the model for simulation of T2D patients is sufficient for simulating fasting glucose......The primary goal of this paper is to predict fasting glucose levels in type 2 diabetes (T2D) in long-acting insulin treatment. The paper presents a model for simulating insulin-glucose dynamics in T2D patients. The model combines a physiological model of type 1 diabetes (T1D) and an endogenous...... insulin production model in T2D. We include a review of sources of variance in fasting glucose values in long-acting insulin treatment, with respect to dose guidance algorithms. We use the model to simulate fasting glucose levels in T2D long-acting insulin treatment and compare the results with clinical...

  18. Development of a Coronary Heart Disease Risk Prediction Model for Type 1 Diabetes: The Pittsburgh CHD in Type 1 Diabetes Risk Mode

    NARCIS (Netherlands)

    Zgibor, J.C.; Ruppert, K.; Orchard, T.J.; Soedamah-Muthu, S.S.; Fuller, J.H.; Chaturvedi, N.; Roberts, M.S.

    2010-01-01

    Aim - To create a coronary heart disease (CHD) risk prediction model specific to type 1 diabetes. Methods - Development of the model used data from the Pittsburgh Epidemiology of Diabetes Complications Study (EDC). EDC subjects had type 1 diabetes diagnosed between 1950 and 1980, received their

  19. Star-type oscillatory networks with generic Kuramoto-type coupling: A model for "Japanese drums synchrony"

    Science.gov (United States)

    Vlasov, Vladimir; Pikovsky, Arkady; Macau, Elbert E. N.

    2015-12-01

    We analyze star-type networks of phase oscillators by virtue of two methods. For identical oscillators we adopt the Watanabe-Strogatz approach, which gives full analytical description of states, rotating with constant frequency. For nonidentical oscillators, such states can be obtained by virtue of the self-consistent approach in a parametric form. In this case stability analysis cannot be performed, however with the help of direct numerical simulations we show which solutions are stable and which not. We consider this system as a model for a drum orchestra, where we assume that the drummers follow the signal of the leader without listening to each other and the coupling parameters are determined by a geometrical organization of the orchestra.

  20. UVB suscetibilidade como fator de risco para o desenvolvimento da hanseníase virchowiana UVB susceptibility as a risk factor to the development of lepromatous leprosy

    Directory of Open Access Journals (Sweden)

    Mecciene Mendes Rodrigues

    2010-12-01

    Full Text Available FUNDAMENTOS: A radiação ultravioleta B (RUVB é o mais importante fator ambiental capaz de modificar a função imunológica da pele humana. OBJETIVO: estudar a associação entre o fenótipo de suscetibilidade ou resistência à radiação RUVB e as formas polares da hanseníase. MATERIAL E MÉTODOS: foram avaliados 38 pacientes com hanseníase virchowiana (MHV e 87 pacientes com hanseníase tuberculoide (MHT de acordo com a classificação de Ridley e Jopling (1966. Todos os pacientes foram submetidos ao teste para determinação do fenótipo de suscetibilidade ou resistência à RUVB por meio da aplicação de um disco de dinitroclorobenzeno (DNCB a 2% em uma área de pele previamente irradiada com duas vezes a dose eritematosa mínima (DEM. Após 21 dias, outra aplicação de um disco similar de DNCB a 0,05% na região escapular (área não exposta à RUVB foi realizada para avaliar se houve sensibilização, com leitura após 48 horas. Os pacientes que apresentaram reação positiva ao DNCB foram considerados UVB-resistentes e o oposto foi considerado para aqueles que não apresentaram resposta (UVB-suscetíveis. RESULTADOS: A frequência de UVB-suscetíveis foi de 63,2% (24 pacientes no grupo MHV e 34,4% (30 pacientes no grupo MHT (OR = 3,26; IC = 1,36-7,87; x² = 7,73; p = 0,005. CONCLUSÃO: Os resultados sugerem que a UVB-suscetibilidade é um fator de risco para o desenvolvimento da MHV.BACKGROUNDS: Ultraviolet radiation B (UVRB is the most important environmental factor capable of altering the immune function of human skin. OBJECTIVE: To evaluate the association of the phenotypes of susceptibility or resistance to ultraviolet radiation B (UVRB and the polar forms of leprosy. MATERIAL AND METHODS: We evaluated 38 patients with lepromatous leprosy (LL and 87 patients with tuberculoid (TT leprosy, according to the classification by Ridley and Jopling (1966. All the patients were submitted to a test to determine the phenotypes of

  1. Dapsone hypersensitivity syndrome in an adolescent during treatment during of leprosy Síndrome de hipersensibilidade à dapsona em uma adolescente durante tratamento de hanseníase

    Directory of Open Access Journals (Sweden)

    Fábio Bucaretchi

    2004-04-01

    Full Text Available A 12 y old girl was admitted 24 days after start a WHO multidrug therapy scheme for multibacillary leprosy (dapsone, clofazimine and rifampicin with intense jaundice, generalized lymphadenopathy, hepatoesplenomegaly, oral erosions, conjunctivitis, morbiliform rash and edema of face, ankles and hands. The main laboratory data on admission included: hemoglobin, 8.4 g/dL; WBC, 15,710 cells/mm³; platelet count, 100,000 cells/mm³; INR = 1.49; increased serum levels of aspartate and alanine aminotransferases, gamma-glutamyl transpeptidase, alkaline phosphatase, direct and indirect bilirubin. Following, the clinical conditions had deteriorated, developing exfoliative dermatitis, shock, generalized edema, acute renal and hepatic failure, pancytopenia, intestinal bleeding, pneumonia, urinary tract infection and bacteremia, needing adrenergic drugs, replacement of fluids and blood product components, and antibiotics. Ten days after admission she started to improve, and was discharged to home at day 39th, after start new supervised treatment for leprosy with clofazimine and rifampicin, without adverse effects. This presentation fulfils the criteria for the diagnosis of dapsone hypersensitivity syndrome (fever, generalized lymphadenopathy, exfoliative rash, anemia and liver involvement with mixed hepatocellular and cholestatic features. Physicians, mainly in geographical areas with high prevalence rates of leprosy, should be aware to this severe, and probably not so rare, hypersensitivity reaction to dapsone.Menina, 12 anos, foi admitida referindo o uso de esquema de poliquimioterapia preconizado pela OMS para tratamento de hanseníase forma multicibacilar (dapsona, rifampicina e clofazimina há 24 dias, apresentando icterícia, linfadenomegalia generalizada, hepatoesplenomegalia, conjuntivite, úlceras orais, exantema morbiliforme e edema de face, mãos e tornozelo. Os principais achados laboratoriais à admissão incluíam: hemoglobina, 8,4 g

  2. Sensitivity Analysis on LOCCW of Westinghouse typed Reactors Considering WOG2000 RCP Seal Leakage Model

    International Nuclear Information System (INIS)

    Na, Jang-Hwan; Jeon, Ho-Jun; Hwang, Seok-Won

    2015-01-01

    In this paper, we focus on risk insights of Westinghouse typed reactors. We identified that Reactor Coolant Pump (RCP) seal integrity is the most important contributor to Core Damage Frequency (CDF). As we reflected the latest technical report; WCAP-15603(Rev. 1-A), 'WOG2000 RCP Seal Leakage Model for Westinghouse PWRs' instead of the old version, RCP seal integrity became more important to Westinghouse typed reactors. After Fukushima accidents, Korea Hydro and Nuclear Power (KHNP) decided to develop Low Power and Shutdown (LPSD) Probabilistic Safety Assessment (PSA) models and upgrade full power PSA models of all operating Nuclear Power Plants (NPPs). As for upgrading full power PSA models, we have tried to standardize the methodology of CCF (Common Cause Failure) and HRA (Human Reliability Analysis), which are the most influential factors to risk measures of NPPs. Also, we have reviewed and reflected the latest operating experiences, reliability data sources and technical methods to improve the quality of PSA models. KHNP has operating various types of reactors; Optimized Pressurized Reactor (OPR) 1000, CANDU, Framatome and Westinghouse. So, one of the most challengeable missions is to keep the balance of risk contributors of all types of reactors. This paper presents the method of new RCP seal leakage model and the sensitivity analysis results from applying the detailed method to PSA models of Westinghouse typed reference reactors. To perform the sensitivity analysis on LOCCW of the reference Westinghouse typed reactors, we reviewed WOG2000 RCP seal leakage model and developed the detailed event tree of LOCCW considering all scenarios of RCP seal failures. Also, we performed HRA based on the T/H analysis by using the leakage rates for each scenario. We could recognize that HRA was the sensitive contributor to CDF, and the RCP seal failure scenario of 182gpm leakage rate was estimated as the most important scenario

  3. Sensitivity Analysis on LOCCW of Westinghouse typed Reactors Considering WOG2000 RCP Seal Leakage Model

    Energy Technology Data Exchange (ETDEWEB)

    Na, Jang-Hwan; Jeon, Ho-Jun; Hwang, Seok-Won [KHNP Central Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    In this paper, we focus on risk insights of Westinghouse typed reactors. We identified that Reactor Coolant Pump (RCP) seal integrity is the most important contributor to Core Damage Frequency (CDF). As we reflected the latest technical report; WCAP-15603(Rev. 1-A), 'WOG2000 RCP Seal Leakage Model for Westinghouse PWRs' instead of the old version, RCP seal integrity became more important to Westinghouse typed reactors. After Fukushima accidents, Korea Hydro and Nuclear Power (KHNP) decided to develop Low Power and Shutdown (LPSD) Probabilistic Safety Assessment (PSA) models and upgrade full power PSA models of all operating Nuclear Power Plants (NPPs). As for upgrading full power PSA models, we have tried to standardize the methodology of CCF (Common Cause Failure) and HRA (Human Reliability Analysis), which are the most influential factors to risk measures of NPPs. Also, we have reviewed and reflected the latest operating experiences, reliability data sources and technical methods to improve the quality of PSA models. KHNP has operating various types of reactors; Optimized Pressurized Reactor (OPR) 1000, CANDU, Framatome and Westinghouse. So, one of the most challengeable missions is to keep the balance of risk contributors of all types of reactors. This paper presents the method of new RCP seal leakage model and the sensitivity analysis results from applying the detailed method to PSA models of Westinghouse typed reference reactors. To perform the sensitivity analysis on LOCCW of the reference Westinghouse typed reactors, we reviewed WOG2000 RCP seal leakage model and developed the detailed event tree of LOCCW considering all scenarios of RCP seal failures. Also, we performed HRA based on the T/H analysis by using the leakage rates for each scenario. We could recognize that HRA was the sensitive contributor to CDF, and the RCP seal failure scenario of 182gpm leakage rate was estimated as the most important scenario.

  4. Physical model of reactor pulse

    International Nuclear Information System (INIS)

    Petrovic, A.; Ravnik, M.

    2004-01-01

    Pulse experiments have been performed at J. Stefan Institute TRIGA reactor since 1991. In total, more than 130 pulses have been performed. Extensive experimental information on the pulse physical characteristics has been accumulated. Fuchs-Hansen adiabatic model has been used for predicting and analysing the pulse parameters. The model is based on point kinetics equation, neglecting the delayed neutrons and assuming constant inserted reactivity in form of step function. Deficiencies of the Fuchs-Hansen model and systematic experimental errors have been observed and analysed. Recently, the pulse model was improved by including the delayed neutrons and time dependence of inserted reactivity. The results explain the observed non-linearity of the pulse energy for high pulses due to finite time of pulse rod withdrawal and the contribution of the delayed neutrons after the prompt part of the pulse. The results of the improved model are in good agreement with experimental results. (author)

  5. Glycogen Storage Disease Type Ia in Canines: A Model for Human Metabolic and Genetic Liver Disease

    OpenAIRE

    Specht, Andrew; Fiske, Laurie; Erger, Kirsten; Cossette, Travis; Verstegen, John; Campbell-Thompson, Martha; Struck, Maggie B.; Lee, Young Mok; Chou, Janice Y.; Byrne, Barry J.; Correia, Catherine E.; Mah, Cathryn S.; Weinstein, David A.; Conlon, Thomas J.

    2011-01-01

    A canine model of Glycogen storage disease type Ia (GSDIa) is described. Affected dogs are homozygous for a previously described M121I mutation resulting in a deficiency of glucose-6-phosphatase-α. Metabolic, clinicopathologic, pathologic, and clinical manifestations of GSDIa observed in this model are described and compared to those observed in humans. The canine model shows more complete recapitulation of the clinical manifestations seen in humans including “lactic acidosis”, larger size,...

  6. Autonomous Decentralized Enterprise Model - A New Wave in Web 2.0 Type E-commerce

    OpenAIRE

    Liu, Feng; Hirano, Makoto

    2010-01-01

    The rapid popularization of Web 2.0 coupled with the growth of e-commerce gives rise to enormous opportunities as well as changes for the creation of new intra-organization models. In the evolving environment of the E-business, this study has attempted to contribute to the framework description of a new type of inter-organizational model in e-commerce enterprises: Autonomous Decentralized Enterprise Model. From this case study,

  7. Bianchi Type-IX viscous fluid cosmological model in general relativity

    Indian Academy of Sciences (India)

    the de-Sitter universe, the Taub-NUT solutions etc. are of Bianchi Type-IX space- times. In these models, neutrino viscosity does not guarantee isotropy at the present ..... The model (2.11) starts with a big-bang at T = 0 where α > 0 and m < 2, and the expansion in the model decreases as time increases. The expansion in the ...

  8. Study on vertical seismic response model of BWR-type reactor building

    International Nuclear Information System (INIS)

    Konno, T.; Motohashi, S.; Izumi, M.; Iizuka, S.

    1993-01-01

    A study on advanced seismic design for LWR has been carried out by the Nuclear Power Engineering Corporation (NUPEC), under the sponsorship of the Ministry of International Trade and Industry (MITI) of Japan. As a part of the study, it has been investigated to construct an accurate analytical model of reactor buildings for a seismic response analysis, which can reasonably represent dynamic characteristics of the building. In Japan, vibration models of reactor buildings for horizontal ground motion have been studied and examined through many simulation analyses for forced vibration tests and earthquake observations of actual buildings. And now it is possible to establish a reliable horizontal vibration model on the basis of multi-lumped mass and spring model. However, vertical vibration models have not been so much studied as horizontal models, due to less observed data for vertical motions. In this paper, the vertical seismic response models of a BWR-type reactor building including soil-structure interaction effect are numerically studied, by comparing the dynamic characteristics of (1) three dimensional finite element model, (2) multi-stick lumped mass model with a flexible base-mat, (3) multi-stick lumped mass model with a rigid base-mat and (4) single-stick lumped mass model. In particular, the BWR-type reactor building has the long span truss roof which is considered to be one of the critical members to vertical excitation. The modelings of the roof trusses are also studied

  9. Improved simulation of two types of El Niño in CMIP5 models

    International Nuclear Information System (INIS)

    Kug, Jong-Seong; Ham, Yoo-Geun; Lee, June-Yi; Jin, Fei-Fei

    2012-01-01

    Using the coupled general circulation models (CGCMs) participating in phases 3 and 5 of the Coupled Model Intercomparison Project (CMIP3 and CMIP5), simulations of the two types of El Niño event are evaluated. Previous studies using CMIP3 models pointed out that most of the models tend to simulate a single type of El Niño, and have serious problems in simulating the two types of El Niño independently. On the average, the CGCMs in CMIP5 have slightly better performance in simulating the two types of El Niño event independently with more distinct spatial patterns, compared to those in CMIP3. It is demonstrated that the precipitation response to Cold Tongue El Niño is one of the important factors in simulating the two types of El Niño independently in coupled models, and this precipitation response is closely related to the dry bias over the equatorial eastern Pacific. (letter)

  10. Establishing the reliability and construct validity of the Igbo version of Screening Activity Limitation and Safety Awareness scale in persons with Hansen disease.

    Science.gov (United States)

    Ibikunle, Peter Olanrewaju; Oladipo, Samuel Ekundayo; Chukwu, Joseph Ngozi; Odole, Adesola Christiana; Okeke, Adaigwe Ifeoma

    2015-09-01

    Leprosy or Hansen's disease is an infectious disease affecting skin and peripheral nerves. The World Health Organization (WHO) Recent Report reveals Africa as having 20,599 new cases, America 36, 178, Eastern Asia 166,445, Western pacific 5,400; totally up to 232,875 new cases. Nigeria as at 2012 had 3,805 new cases. Nerve dysfunction can lead to severe impairments, such as wounds, clawing and shortening of digits, and visual impairments that are often indicated as WHO Grade 2 disabilities. The Screening Activity Limitation Safety Awareness (SALSA) scale however, was developed to-measure self-reported activity limitation in people affected by peripheral neuropathy, and has been translated into several languages world-wide, including two of the three major indigenous languages in Nigeria (i.e. Yoruba and Hausa), leaving the Igbo language yet to be translated. This resulted in the present study, in which the scale was translated into Igbo and the psychometric properties also established to help in data collection and to promote research among the Igbo speaking people living with disabilities from Hansen's disease. The research design was a cross-sectional survey, facility based with 70% RFT and 30% on MDT. Data were analysed using Cronbach's alpha and factor analyses. A quantitative exploration of participants' characteristics revealed that of the 40 respondents that participated in the study; 87.5% of them were predominantly from a rural population; 42.5% were males and 57.5% females. Their ages ranged between 15 and 64 years; 55% were uneducated; while 45% were educated. The SALSA Scale was interviewer-administered to the participants. Reliability analysis conducted on the data revealed high Cronbach's alpha co-efficient of 0.93 - 0.94 for the entire items on the scale. Firstly, most of the scale items correlated at least 0.3 with at least one other item on the scale, Secondly, the Kaiser-Meyer-Olkin measure of sampling adequacy was 0.71, Bartlett's test of

  11. Sorologia da hanseníase utilizando PGL-I: revisão sistemática Leprosy serology using PGL-I: a systematic review

    Directory of Open Access Journals (Sweden)

    Rodrigo Scaliante de Moura

    2008-01-01

    Full Text Available A sorologia utilizando o antígeno espécie-específico do Mycobacterium leprae, PGL-I, pode ser um marcador de carga bacteriana em pacientes com hanseníase. Estudos identificaram potencial de uso da sorologia na classificação de pacientes para fins de tratamento, monitoramento de terapia, risco de recidiva e na seleção dos contatos com maior risco de adoecer. Foi realizada uma revisão sistemática e 26 artigos foram incluídos na análise comparativa. Avaliamos os resultados do uso da sorologia PGL-I em diferentes situações, suas limitações e possíveis aplicações. Estudos mostraram eficácia da sorologia PGL-I na classificação de pacientes, monitoramento da terapia, e nas reações hansênicas como teste preditivo. Para diagnóstico precoce e seguimento de população de alto risco, as metodologias utilizadas ainda não demonstraram custo-benefício favorável, porém estudos indicam que a utilização do teste poderá influenciar positivamente nos programas de controle da hanseníase. Com técnicas simples e robustas, o uso da sorologia PGL-I é viável.Serology using a species-specific antigen for Mycobacterium leprae, PGL-I, could be a marker for the bacterial load of patients with leprosy. Various studies have identified the potential use of serology in the classification of patients for treatment purposes, case monitoring, identification of the risk of relapse and selection of household contacts with a higher risk of contracting the disease. A systematic review of the literature was conducted and 26 articles were included in this comparative analysis. The results of the use of PGL-I serology in different situations, its limitations and possible applications were evaluated. Studies show the efficacy of PGL-I serology in the classification of patients, treatment monitoring and as a predictive test for leprosy reactions. To improve early diagnosis and follow-up of the population at greatest risk of developing leprosy, the

  12. Asteroseismic modelling of the solar-type subgiant star β Hydri

    DEFF Research Database (Denmark)

    Brandão, I.M.; Dogan, Gülnur; Christensen-Dalsgaard, Jørgen

    2011-01-01

    Context. Comparing models and data of pulsating stars is a powerful way to understand the stellar structure better. Moreover, such comparisons are necessary to make improvements to the physics of the stellar models, since they do not yet perfectly represent either the interior or especially...... the surface layers of stars. Because β Hydri is an evolved solar-type pulsator with mixed modes in its frequency spectrum, it is very interesting for asteroseismic studies. Aims: The goal of the present work is to search for a representative model of the solar-type star β Hydri, based on up-to-date non...... frequencies of β Hydri: (i) we assume that the best model is the one that reproduces the star's interior based on the radial oscillation frequencies alone, to which we have applied the correction for the near-surface effects; (ii) we assume that the best model is the one that produces the lowest value...

  13. Comparison of the WSA-ENLIL model with three CME cone types

    Science.gov (United States)

    Jang, Soojeong; Moon, Y.; Na, H.

    2013-07-01

    We have made a comparison of the CME-associated shock propagation based on the WSA-ENLIL model with three cone types using 29 halo CMEs from 2001 to 2002. These halo CMEs have cone model parameters as well as their associated interplanetary (IP) shocks. For this study we consider three different cone types (an asymmetric cone model, an ice-cream cone model and an elliptical cone model) to determine 3-D CME parameters (radial velocity, angular width and source location), which are the input values of the WSA-ENLIL model. The mean absolute error (MAE) of the arrival times for the asymmetric cone model is 10.6 hours, which is about 1 hour smaller than those of the other models. Their ensemble average of MAE is 9.5 hours. However, this value is still larger than that (8.7 hours) of the empirical model of Kim et al. (2007). We will compare their IP shock velocities and densities with those from ACE in-situ measurements and discuss them in terms of the prediction of geomagnetic storms.Abstract (2,250 Maximum Characters): We have made a comparison of the CME-associated shock propagation based on the WSA-ENLIL model with three cone types using 29 halo CMEs from 2001 to 2002. These halo CMEs have cone model parameters as well as their associated interplanetary (IP) shocks. For this study we consider three different cone types (an asymmetric cone model, an ice-cream cone model and an elliptical cone model) to determine 3-D CME parameters (radial velocity, angular width and source location), which are the input values of the WSA-ENLIL model. The mean absolute error (MAE) of the arrival times for the asymmetric cone model is 10.6 hours, which is about 1 hour smaller than those of the other models. Their ensemble average of MAE is 9.5 hours. However, this value is still larger than that (8.7 hours) of the empirical model of Kim et al. (2007). We will compare their IP shock velocities and densities with those from ACE in-situ measurements and discuss them in terms of the

  14. Glycogen storage disease type Ia in canines: a model for human metabolic and genetic liver disease.

    Science.gov (United States)

    Specht, Andrew; Fiske, Laurie; Erger, Kirsten; Cossette, Travis; Verstegen, John; Campbell-Thompson, Martha; Struck, Maggie B; Lee, Young Mok; Chou, Janice Y; Byrne, Barry J; Correia, Catherine E; Mah, Cathryn S; Weinstein, David A; Conlon, Thomas J

    2011-01-01

    A canine model of Glycogen storage disease type Ia (GSDIa) is described. Affected dogs are homozygous for a previously described M121I mutation resulting in a deficiency of glucose-6-phosphatase-α. Metabolic, clinicopathologic, pathologic, and clinical manifestations of GSDIa observed in this model are described and compared to those observed in humans. The canine model shows more complete recapitulation of the clinical manifestations seen in humans including "lactic acidosis", larger size, and longer lifespan compared to other animal models. Use of this model in preclinical trials of gene therapy is described and briefly compared to the murine model. Although the canine model offers a number of advantages for evaluating potential therapies for GSDIa, there are also some significant challenges involved in its use. Despite these challenges, the canine model of GSDIa should continue to provide valuable information about the potential for generating curative therapies for GSDIa as well as other genetic hepatic diseases.

  15. Glycogen Storage Disease Type Ia in Canines: A Model for Human Metabolic and Genetic Liver Disease

    Directory of Open Access Journals (Sweden)

    Andrew Specht

    2011-01-01

    Full Text Available A canine model of Glycogen storage disease type Ia (GSDIa is described. Affected dogs are homozygous for a previously described M121I mutation resulting in a deficiency of glucose-6-phosphatase-α. Metabolic, clinicopathologic, pathologic, and clinical manifestations of GSDIa observed in this model are described and compared to those observed in humans. The canine model shows more complete recapitulation of the clinical manifestations seen in humans including “lactic acidosis”, larger size, and longer lifespan compared to other animal models. Use of this model in preclinical trials of gene therapy is described and briefly compared to the murine model. Although the canine model offers a number of advantages for evaluating potential therapies for GSDIa, there are also some significant challenges involved in its use. Despite these challenges, the canine model of GSDIa should continue to provide valuable information about the potential for generating curative therapies for GSDIa as well as other genetic hepatic diseases.

  16. A Beddoes-Leishman type dynamic stall model in state-space and indicial formulations

    DEFF Research Database (Denmark)

    Hansen, M.H.; Gaunaa, Mac; Aagaard Madsen, Helge

    2004-01-01

    This report contains a description of a Beddoes-Leishman type dynamic stall model in both a state-space and an indicial function formulation. The model predicts the unsteady aerodynamic forces and moment on an airfoil section undergoing arbitrary motionin heave, lead-lag, and pitch. The model...... features, such as overshoot of the lift, in the stall region. The linearized model is shown to give identicalresults to the full model for small amplitude oscillations. Furthermore, it is shown that the response of finite thichkness airfoils can be reproduced to a high accuracy by the use of specific...... is carried out by comparing the response of the model with inviscid solutions and observing the general behavior of the model using known airfoil data as input. Theproposed dynamic model gives results identical to inviscid solutions within the attached-flow region; and it exhibits the expected dynamic...

  17. Certain Type Turbofan Engine Whole Vibration Model with Support Looseness Fault and Casing Response Characteristics

    Directory of Open Access Journals (Sweden)

    H. F. Wang

    2014-01-01

    Full Text Available Support looseness fault is a type of common fault in aeroengine. Serious looseness fault would emerge under larger unbalanced force, which would cause excessive vibration and even lead to rubbing fault, so it is important to analyze and recognize looseness fault effectively. In this paper, based on certain type turbofan engine structural features, a rotor-support-casing whole model for certain type turbofan aeroengine is established. The rotor and casing systems are modeled by means of the finite element beam method; the support systems are modeled by lumped-mass model; the support looseness fault model is also introduced. The coupled system response is obtained by numerical integral method. In this paper, based on the casing acceleration signals, the impact characteristics of symmetrical stiffness and asymmetric stiffness models are analyzed, finding that the looseness fault would lead to the longitudinal asymmetrical characteristics of acceleration time domain wave and the multiple frequency characteristics, which is consistent with the real trial running vibration signals. Asymmetric stiffness looseness model is verified to be fit for aeroengine looseness fault model.

  18. Investigation of time and weather effects on crash types using full Bayesian multivariate Poisson lognormal models.

    Science.gov (United States)

    El-Basyouny, Karim; Barua, Sudip; Islam, Md Tazul

    2014-12-01

    Previous research shows that various weather elements have significant effects on crash occurrence and risk; however, little is known about how these elements affect different crash types. Consequently, this study investigates the impact of weather elements and sudden extreme snow or rain weather changes on crash type. Multivariate models were used for seven crash types using five years of daily weather and crash data collected for the entire City of Edmonton. In addition, the yearly trend and random variation of parameters across the years were analyzed by using four different modeling formulations. The proposed models were estimated in a full Bayesian context via Markov Chain Monte Carlo simulation. The multivariate Poisson lognormal model with yearly varying coefficients provided the best fit for the data according to Deviance Information Criteria. Overall, results showed that temperature and snowfall were statistically significant with intuitive signs (crashes decrease with increasing temperature; crashes increase as snowfall intensity increases) for all crash types, while rainfall was mostly insignificant. Previous snow showed mixed results, being statistically significant and positively related to certain crash types, while negatively related or insignificant in other cases. Maximum wind gust speed was found mostly insignificant with a few exceptions that were positively related to crash type. Major snow or rain events following a dry weather condition were highly significant and positively related to three crash types: Follow-Too-Close, Stop-Sign-Violation, and Ran-Off-Road crashes. The day-of-the-week dummy variables were statistically significant, indicating a possible weekly variation in exposure. Transportation authorities might use the above results to improve road safety by providing drivers with information regarding the risk of certain crash types for a particular weather condition. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Avaliação dos parâmetros de solubilidade de Hildebrand/Hansen na seleção de solventes para a extração de pesticidas organoclorados do solo

    Directory of Open Access Journals (Sweden)

    Ricardo D Villa

    2011-09-01

    Full Text Available This work evaluated the use of the Hildebrand/Hansen solubility parameters for selection of solvents for extraction of the organochlorine pesticides pp' DDT, pp' DDE, Aldrin and a-Endossulfan from soil using columns packed with Al2O3. The mixtures hexane:dichloromethane (7:3; v/v, hexane:acetonitrile (1:1; v/v, hexane:acetone (1:1; v/v and pure hexane were chosen as extracting solutions. In the addition and recovery tests, different extraction solutions provided high recoveries percentages (>75% with coefficients of variation below 15%. The recoveries are in agreement with the Hildebrand/Hansen parameters, demonstrating its applicability in the selection of extracting solution and in the replacement of toxic solvents, as dichloromethane

  20. A ação educativa do enfermeiro educador na estratégia Saúde da Família ao portador de hanseníase

    OpenAIRE

    Alberici, Priscila de Souza; UNIABEU; Jóia, Thalita; UNIABEU; Moreira, Leandro Arantes; UNIABEU

    2011-01-01

    Introdução: O enfermeiro na Estratégia Saúde da Família como educador, objetivando a promoção da saúde e a prevenção da doença. Problemática: Seria a falta de conhecimento/comprometimento do profissional de saúde em relação à gravidade da doença o motivo pelo qual o Brasil não erradicar a hanseníase? Objetivo: Refletir sobre a ação educativa do enfermeiro na ESF ao portador de hanseníase. Metodologia: Estudo descritivo e exploratório, método de abordagem qualitativa. A revisão bibliográfica s...

  1. Estudo da microcirculação na hanseníase usando videomicroscopia (Microscan) e laser-Doppler associado à iontoforese: um modelo de disautonomia vascular por denervação

    OpenAIRE

    Livia Cristina de Melo Pino Machado

    2013-01-01

    A hanseníase é uma doença infecciosa com características únicas, dentre elas o fato de atingir intensamente a inervação da pele e seus anexos. Entremeando estes anexos, está a microcirculação cutânea, que a principio também tem sua inervação comprometida. Vários artigos apontam para alterações de disautonomiamicrocirculatória. O presente estudo se propõe a avaliar a microcirculação cutânea na hanseníase tuberculóide. Utilizamos a videomicroscopia de campo escuro (Microscan), a análise de Four...

  2. Avaliação da limitação das atividades diárias e qualidade de vida de pacientes com hanseníase submetidos à cirurgia de neurólise para tratamento das neurites

    OpenAIRE

    Reis,Felipe José Jandre dos; Gomes,Maria Kátia; Cunha,Antonio José Ledo Alves da

    2013-01-01

    A neurólise é indicada para reduzir o ­sofrimento neural e impedir a instalação de sequelas e incapacidades em pacientes com hanseníase. O objetivo deste estudo foi verificar o grau de limitação das atividades e a qualidade de vida de pacientes com hanseníase submetidos a neurólise para tratamento das neurites. Participaram do estudo os pacientes submetidos à neurólise no período de 1998 a 2011. Foram coletadas informações sociodemográficas e clínicas, limitações das atividades (SALSA) e a qu...

  3. Mensuração do ângulo articular do cotovelo no teste de tensão neural em indivíduos com hanseníase

    OpenAIRE

    Scheibe,Débora; Oliveira,Jaqueline Francieli Pacheco de; Gonçalves,Sibelly Blum; Gomes,Anna Raquel Silveira; Macedo,Ana Carolina Brandt de

    2012-01-01

    A hanseníase é uma patologia crônica e granulomatosa, que atinge a pele e o sistema nervoso periférico pela invasão no sistema imune do Mycobacterium leprae. O objetivo deste estudo foi mensurar o ângulo articular do cotovelo com a aplicação do teste de tensão neural do nervo ulnar em pacientes com hanseníase. Na aplicação do teste de tensão neural, foram utilizadas a goniometria e a fotometria para a mensuração do ângulo articular do cotovelo, sendo que para a realização da fotometria foi ut...

  4. Espaços vigiados: um estudo do isolamento compulsório dos portadores de hanseníase no asilo-colônia Santo Ângelo (1890/1960)

    OpenAIRE

    Vânia Regina Miranda Postigo

    2008-01-01

    Esta pesquisa procura analisar o isolamento compulsório dos portadores de hanseníase no Asilo-colônia Santo Ângelo localizado em Mogi das Cruzes, São Paulo, tendo como ponto de partida os anos 1890, época em que as primeiras medidas de controle da hanseníase e de outras doenças foram adotadas pelo poder público paulista. A criação de várias instituições e do primeiro código sanitário marcaram o início da construção de uma forte estrutura para o desenvolvimento de políticas públicas de saúde n...

  5. Type II pp-wave matrix models from point-like gravitons

    International Nuclear Information System (INIS)

    Lozano, Yolanda; RodrIguez-Gomez, Diego

    2006-01-01

    The BMN Matrix model can be regarded as a theory of coincident M-theory gravitons, which expand by Myers dielectric effect into the 2-sphere and 5-sphere giant graviton vacua of the theory. In this note we show that, in the same fashion, Matrix String theory in Type IIA pp-wave backgrounds arises from the action for coincident Type IIA gravitons. In Type IIB, we show that the action for coincident gravitons in the maximally supersymmetric pp-wave background gives rise to a Matrix model which supports fuzzy 3-sphere giant graviton vacua with the right behavior in the classical limit. We discuss the relation between our Matrix model and the Tiny Graviton Matrix theory

  6. Neutrinoless double beta decay in type I+II seesaw models

    Energy Technology Data Exchange (ETDEWEB)

    Borah, Debasish [Department of Physics, Tezpur University,Tezpur-784028 (India); Dasgupta, Arnab [Institute of Physics, Sachivalaya Marg,Bhubaneshwar-751005 (India)

    2015-11-30

    We study neutrinoless double beta decay in left-right symmetric extension of the standard model with type I and type II seesaw origin of neutrino masses. Due to the enhanced gauge symmetry as well as extended scalar sector, there are several new physics sources of neutrinoless double beta decay in this model. Ignoring the left-right gauge boson mixing and heavy-light neutrino mixing, we first compute the contributions to neutrinoless double beta decay for type I and type II dominant seesaw separately and compare with the standard light neutrino contributions. We then repeat the exercise by considering the presence of both type I and type II seesaw, having non-negligible contributions to light neutrino masses and show the difference in results from individual seesaw cases. Assuming the new gauge bosons and scalars to be around a TeV, we constrain different parameters of the model including both heavy and light neutrino masses from the requirement of keeping the new physics contribution to neutrinoless double beta decay amplitude below the upper limit set by the GERDA experiment and also satisfying bounds from lepton flavor violation, cosmology and colliders.

  7. Potential overestimation of HPV vaccine impact due to unmasking of non-vaccine types: quantification using a multi-type mathematical model.

    Science.gov (United States)

    Choi, Yoon Hong; Chapman, Ruth; Gay, Nigel; Jit, Mark

    2012-05-14

    Estimates of human papillomavirus (HPV) vaccine impact in clinical trials and modelling studies rely on DNA tests of cytology or biopsy specimens to determine the HPV type responsible for a cervical lesion. DNA of several oncogenic HPV types may be detectable in a specimen. However, only one type may be responsible for a particular cervical lesion. Misattribution of the causal HPV type for a particular abnormality may give rise to an apparent increase in disease due to non-vaccine HPV types following vaccination ("unmasking"). To investigate the existence and magnitude of unmasking, we analysed data from residual cytology and biopsy specimens in English women aged 20-64 years old using a stochastic type-specific individual-based model of HPV infection, progression and disease. The model parameters were calibrated to data on the prevalence of HPV DNA and cytological lesion of different grades, and used to assign causal HPV types to cervical lesions. The difference between the prevalence of all disease due to non-vaccine HPV types, and disease due to non-vaccine HPV types in the absence of vaccine HPV types, was then estimated. There could be an apparent maximum increase of 3-10% in long-term cervical cancer incidence due to non-vaccine HPV types following vaccination. Unmasking may be an important phenomenon in HPV post-vaccination epidemiology, in the same way that has been observed following pneumococcal conjugate vaccination. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. Theoretical model for investigating the dynamic behaviour of the AST-500 type nuclear heating station reactor

    International Nuclear Information System (INIS)

    Grundmann, U.; Rohde, U.; Naumann, B.

    1985-01-01

    Studies on theoretical simulation of the dynamic behaviour of the AST-500 type reactor primary coolant system are summarized. The first version of a dynamic model in the form of the DYNAST code is described. The DYNAST code is based on a one-dimensional description of the primary coolant circuit including core, draught stack, and intermediate heat exchanger, a vapour dome model, and the point model of neutron kinetics. With the aid of the steady-state computational part of the DYNAST code, studies have been performed on different steady-state operating conditions. Furthermore, some methodological investigations on generalization and improvement of the dynamic model are considered and results presented. (author)

  9. Model Identification using Continuous Glucose Monitoring Data for Type 1 Diabetes

    DEFF Research Database (Denmark)

    Boiroux, Dimitri; Hagdrup, Morten; Mahmoudi, Zeinab

    2016-01-01

    This paper addresses model identification of continuous-discrete nonlinear models for people with type 1 diabetes using sampled data from a continuous glucose monitor (CGM). We compare five identification techniques: least squares, weighted least squares, Huber regression, maximum likelihood...... with extended Kalman filter and maximum likelihood with unscented Kalman filter. We perform the identification on a 24-hour simulation of a stochastic differential equation (SDE) version of the Medtronic Virtual Patient (MVP) model including process and output noise. We compare the fits with the actual CGM......, such as parameter tracking, population modeling and handling of outliers....

  10. LRS Bianchi Type II Massive String Cosmological Models with Magnetic Field in Lyra's Geometry

    Directory of Open Access Journals (Sweden)

    Raj Bali

    2013-01-01

    Full Text Available Bianchi type II massive string cosmological models with magnetic field and time dependent gauge function ( in the frame work of Lyra's geometry are investigated. The magnetic field is in -plane. To get the deterministic solution, we have assumed that the shear ( is proportional to the expansion (. This leads to , where and are metric potentials and is a constant. We find that the models start with a big bang at initial singularity and expansion decreases due to lapse of time. The anisotropy is maintained throughout but the model isotropizes when . The physical and geometrical aspects of the model in the presence and absence of magnetic field are also discussed.

  11. Review on the HVAC System Modeling Types and the Shortcomings of Their Application

    Directory of Open Access Journals (Sweden)

    Raad Z. Homod

    2013-01-01

    Full Text Available The modeling of the heating, ventilation, and air conditioning (HVAC system is a prominent topic because of its relationship with energy savings and environmental, economical, and technological issues. The modeling of the HVAC system is concerned with the indoor thermal sensation, which is related to the modeling of building, air handling unit (AHU equipments, and indoor thermal processes. Until now, many HVAC system modeling approaches are made available, and the techniques have become quite mature. But there are some shortcomings in application and integration methods for the different types of the HVAC model. The application and integration processes will act to accumulate the defective characteristics for both AHU equipments and building models such as nonlinear, pure lag time, high thermal inertia, uncertain disturbance factors, large-scale systems, and constraints. This paper shows types of the HVAC model and the advantages and disadvantages for each application of them, and it finds out that the gray-box type is the best one to represent the indoor thermal comfort. But its application fails at the integration method where its response deviated to unreal behavior.

  12. Modeling of luminance distribution in CAVE-type virtual reality systems

    Science.gov (United States)

    Meironke, Michał; Mazikowski, Adam

    2017-08-01

    At present, one of the most advanced virtual reality systems are CAVE-type (Cave Automatic Virtual Environment) installations. Such systems are usually consisted of four, five or six projection screens and in case of six screens arranged in form of a cube. Providing the user with a high level of immersion feeling in such systems is largely dependent of optical properties of the system. The modeling of physical phenomena plays nowadays a huge role in the most fields of science and technology. It allows to simulate work of device without a need to make any changes in the physical constructions. In this paper distribution of luminance in CAVE-type virtual reality systems were modelled. Calculations were performed for the model of 6-walled CAVE-type installation, based on Immersive 3D Visualization Laboratory, situated at the Faculty of Electronics, Telecommunications and Informatics at the Gdańsk University of Technology. Tests have been carried out for two different scattering distribution of the screen material in order to check how these characteristicinfluence on the luminance distribution of the whole CAVE. The basis assumption and simplification of modeled CAVE-type installation and results were presented. The brief discussion about the results and usefulness of developed model were also carried out.

  13. Hansen solubility parameters (HSP) for prescreening formulation of solid lipid nanoparticles (SLN): in vitro testing of curcumin-loaded SLN in MCF-7 and BT-474 cell lines.

    Science.gov (United States)

    Doktorovova, Slavomira; Souto, Eliana B; Silva, Amélia M

    2018-01-01

    Curcumin, a phenolic compound from turmeric rhizome (Curcuma longa), has many interesting pharmacological effects, but shows very low aqueous solubility. Consequently, several drug delivery systems based on polymeric and lipid raw materials have been proposed to increase its bioavailability. Solid lipid nanoparticles (SLN), consisting of solid lipid matrix and a surfactant layer can load poorly water-soluble drugs, such as curcumin, deliver them at defined rates and enhance their intracellular uptake. In the present work, we demonstrate that, despite the drug's affinity to lipids frequently used in SLN production, the curcumin amount loaded in most SLN formulations may be too low to exhibit anticancer properties. The predictive curcumin solubility in solid lipids has been thoroughly analyzed by Hansen solubility parameters, in parallel with the lipid-screening solubility tests for a range of selected lipids. We identified the most suitable lipid materials for curcumin-loaded SLN, producing physicochemically stable particles with high encapsulation efficiency (>90%). Loading capacity of curcumin in SLN allowed preventing the cellular damage caused by cationic SLN on MCF-7 and BT-474 cells but was not sufficient to exhibit drug's anticancer properties. But curcumin-loaded SLN exhibited antioxidant properties, substantiating the conclusions that curcumin's effect in cancer cells is highly dose dependent.

  14. A New Economic and Political State of Play in the Energy Sector: On Jean-Pierre Hansen and Jacques Percebois, Energy. Economy and politics

    International Nuclear Information System (INIS)

    Lesourne, J.

    2011-01-01

    If there is one sector in which the state of play has changed radically over a few decades, it is the energy sector. It has been affected simultaneously by the prospect that the main fossil fuels will become exhausted, by the impact on our planet's climate of the consumption of this fossil energy (implying increased recourse to renewable sources) and by the rapid economic development of large nations consuming increasing quantities of energy. Energy-related policies (particularly economic and technological policies) are, in fact, being developed in an increasingly complex and international context, which is, at times, very difficult to grasp. Fortunately, two specialists in energy matters, Jean-Pierre Hansen and Jacques Percebois, have published a very comprehensive survey of this new economic and political state of play in the energy field: 'Energie. Economie et politiques' [Energy: Economics and Policies] (Brussels: De Boeck, 2010). It clearly is not possible here to go into all the questions they confront, but in this review Jacques Lesourne, who has read the book for Futuribles, clearly demonstrates its importance and presents the reader with the main facets of the work that make it a reference tool for all involved in this sector, including the most highly specialized. (author)

  15. Kaluza–Klein-type models of de Sitter and Poincaré gauge theories of gravity

    International Nuclear Information System (INIS)

    Lu Jiaan; Huang Chaoguang

    2013-01-01

    We construct Kaluza–Klein-type models with a de Sitter or Minkowski bundle in the de Sitter or Poincaré gauge theory of gravity, respectively. A manifestly gauge-invariant formalism has been given. The gravitational dynamics is constructed by the geometry of the de Sitter or Minkowski bundle and a global section which plays an important role in the gauge-invariant formalism. Unlike the old Kaluza–Klein-type models of gauge theory of gravity, a suitable cosmological term can be obtained in the Lagrangian of our models and the models in the spin-current-free and torsion-free limit will come back to general relativity with a corresponding cosmological term. We also generalize the results to the case with a variable cosmological term. (paper)

  16. Six types of multistability in a neuronal model based on slow calcium current.

    Directory of Open Access Journals (Sweden)

    Tatiana Malashchenko

    Full Text Available BACKGROUND: Multistability of oscillatory and silent regimes is a ubiquitous phenomenon exhibited by excitable systems such as neurons and cardiac cells. Multistability can play functional roles in short-term memory and maintaining posture. It seems to pose an evolutionary advantage for neurons which are part of multifunctional Central Pattern Generators to possess multistability. The mechanisms supporting multistability of bursting regimes are not well understood or classified. METHODOLOGY/PRINCIPAL FINDINGS: Our study is focused on determining the bio-physical mechanisms underlying different types of co-existence of the oscillatory and silent regimes observed in a neuronal model. We develop a low-dimensional model typifying the dynamics of a single leech heart interneuron. We carry out a bifurcation analysis of the model and show that it possesses six different types of multistability of dynamical regimes. These types are the co-existence of 1 bursting and silence, 2 tonic spiking and silence, 3 tonic spiking and subthreshold oscillations, 4 bursting and subthreshold oscillations, 5 bursting, subthreshold oscillations and silence, and 6 bursting and tonic spiking. These first five types of multistability occur due to the presence of a separating regime that is either a saddle periodic orbit or a saddle equilibrium. We found that the parameter range wherein multistability is observed is limited by the parameter values at which the separating regimes emerge and terminate. CONCLUSIONS: We developed a neuronal model which exhibits a rich variety of different types of multistability. We described a novel mechanism supporting the bistability of bursting and silence. This neuronal model provides a unique opportunity to study the dynamics of networks with neurons possessing different types of multistability.

  17. How to Maximize the Likelihood Function for a DSGE Model

    DEFF Research Database (Denmark)

    Andreasen, Martin Møller

    This paper extends two optimization routines to deal with objective functions for DSGE models. The optimization routines are i) a version of Simulated Annealing developed by Corana, Marchesi & Ridella (1987), and ii) the evolutionary algorithm CMA-ES developed by Hansen, Müller & Koumoutsakos (2003...

  18. A decision-making model for engineering designers

    DEFF Research Database (Denmark)

    Ahmed, S.; Hansen, Claus Thorp

    2002-01-01

    This paper describes research that combines the generic decision-making model of Hansen, together with design strategies employed by experienced engineering designers. The relationship between the six decision-making sub-activities and the eight design strategies are examined. By combining...

  19. Small-animal PET imaging of the type 1 and type 2 cannabinoid receptors in a photothrombotic stroke model

    International Nuclear Information System (INIS)

    Vandeputte, Caroline; Casteels, Cindy; Koole, Michel; Gerits, Anneleen; Struys, Tom; Veghel, Daisy van; Evens, Nele; Bormans, Guy; Dresselaers, Tom; Himmelreich, Uwe; Lambrichts, Ivo; Laere, Koen van

    2012-01-01

    Recent ex vivo and pharmacological evidence suggests involvement of the endocannabinoid system in the pathophysiology of stroke, but conflicting roles for type 1 and 2 cannabinoid receptors (CB 1 and CB 2 ) have been suggested. The purpose of this study was to evaluate CB 1 and CB 2 receptor binding over time in vivo in a rat photothrombotic stroke model using PET. CB 1 and CB 2 microPET imaging was performed at regular time-points up to 2 weeks after stroke using [ 18 F]MK-9470 and [ 11 C]NE40. Stroke size was measured using MRI at 9.4 T. Ex vivo validation was performed via immunostaining for CB 1 and CB 2 . Immunofluorescent double stainings were also performed with markers for astrocytes (GFAP) and macrophages/microglia (CD68). [ 18 F]MK-9470 PET showed a strong increase in CB 1 binding 24 h and 72 h after stroke in the cortex surrounding the lesion, extending to the insular cortex 24 h after surgery. These alterations were consistently confirmed by CB 1 immunohistochemical staining. [ 11 C]NE40 did not show any significant differences between stroke and sham-operated animals, although staining for CB 2 revealed minor immunoreactivity at 1 and 2 weeks after stroke in this model. Both CB 1 + and CB 2 + cells showed minor immunoreactivity for CD68. Time-dependent and regionally strongly increased CB 1 , but not CB 2 , binding are early consequences of photothrombotic stroke. Pharmacological interventions should primarily aim at CB 1 signalling as the role of CB 2 seems minor in the acute and subacute phases of stroke. (orig.)

  20. Small-animal PET imaging of the type 1 and type 2 cannabinoid receptors in a photothrombotic stroke model

    Energy Technology Data Exchange (ETDEWEB)

    Vandeputte, Caroline; Casteels, Cindy; Koole, Michel; Gerits, Anneleen [KU Leuven, Division of Nuclear Medicine, Leuven (Belgium); KU Leuven, Molecular Small Animal Imaging Center, MoSAIC, Leuven (Belgium); Struys, Tom [Hasselt University, Laboratory of Histology, Biomedical Research Institute, Hasselt (Belgium); KU Leuven, Biomedical NMR Unit, Leuven (Belgium); Veghel, Daisy van; Evens, Nele; Bormans, Guy [KU Leuven, Molecular Small Animal Imaging Center, MoSAIC, Leuven (Belgium); KU Leuven, Laboratory of Radiopharmacy, Leuven (Belgium); Dresselaers, Tom; Himmelreich, Uwe [KU Leuven, Molecular Small Animal Imaging Center, MoSAIC, Leuven (Belgium); KU Leuven, Biomedical NMR Unit, Leuven (Belgium); Lambrichts, Ivo [Hasselt University, Laboratory of Histology, Biomedical Research Institute, Hasselt (Belgium); Laere, Koen van [KU Leuven, Division of Nuclear Medicine, Leuven (Belgium); KU Leuven, Molecular Small Animal Imaging Center, MoSAIC, Leuven (Belgium); UZ Leuven, Division of Nuclear Medicine, Leuven (Belgium)

    2012-11-15

    Recent ex vivo and pharmacological evidence suggests involvement of the endocannabinoid system in the pathophysiology of stroke, but conflicting roles for type 1 and 2 cannabinoid receptors (CB{sub 1} and CB{sub 2}) have been suggested. The purpose of this study was to evaluate CB{sub 1} and CB{sub 2} receptor binding over time in vivo in a rat photothrombotic stroke model using PET. CB{sub 1} and CB{sub 2} microPET imaging was performed at regular time-points up to 2 weeks after stroke using [{sup 18}F]MK-9470 and [{sup 11}C]NE40. Stroke size was measured using MRI at 9.4 T. Ex vivo validation was performed via immunostaining for CB{sub 1} and CB{sub 2}. Immunofluorescent double stainings were also performed with markers for astrocytes (GFAP) and macrophages/microglia (CD68). [{sup 18}F]MK-9470 PET showed a strong increase in CB{sub 1} binding 24 h and 72 h after stroke in the cortex surrounding the lesion, extending to the insular cortex 24 h after surgery. These alterations were consistently confirmed by CB{sub 1} immunohistochemical staining. [{sup 11}C]NE40 did not show any significant differences between stroke and sham-operated animals, although staining for CB{sub 2} revealed minor immunoreactivity at 1 and 2 weeks after stroke in this model. Both CB{sub 1} {sup +} and CB{sub 2} {sup +} cells showed minor immunoreactivity for CD68. Time-dependent and regionally strongly increased CB{sub 1}, but not CB{sub 2}, binding are early consequences of photothrombotic stroke. Pharmacological interventions should primarily aim at CB{sub 1} signalling as the role of CB{sub 2} seems minor in the acute and subacute phases of stroke. (orig.)

  1. Modeling of a ring rosen-type piezoelectric transformer by Hamilton's principle.

    Science.gov (United States)

    Nadal, Clément; Pigache, Francois; Erhart, Jiří

    2015-04-01

    This paper deals with the analytical modeling of a ring Rosen-type piezoelectric transformer. The developed model is based on a Hamiltonian approach, enabling to obtain main parameters and performance evaluation for the first radial vibratory modes. Methodology is detailed, and final results, both the input admittance and the electric potential distribution on the surface of the secondary part, are compared with numerical and experimental ones for discussion and validation.

  2. A Systematic Review of Cost-Effectiveness Models in Type 1 Diabetes Mellitus.

    Science.gov (United States)

    Henriksson, Martin; Jindal, Ramandeep; Sternhufvud, Catarina; Bergenheim, Klas; Sörstadius, Elisabeth; Willis, Michael

    2016-06-01

    Critiques of cost-effectiveness modelling in type 1 diabetes mellitus (T1DM) are scarce and are often undertaken in combination with type 2 diabetes mellitus (T2DM) models. However, T1DM is a separate disease, and it is therefore important to appraise modelling methods in T1DM. This review identified published economic models in T1DM and provided an overview of the characteristics and capabilities of available models, thus enabling a discussion of best-practice modelling approaches in T1DM. A systematic review of Embase(®), MEDLINE(®), MEDLINE(®) In-Process, and NHS EED was conducted to identify available models in T1DM. Key conferences and health technology assessment (HTA) websites were also reviewed. The characteristics of each model (e.g. model structure, simulation method, handling of uncertainty, incorporation of treatment effect, data for risk equations, and validation procedures, based on information in the primary publication) were extracted, with a focus on model capabilities. We identified 13 unique models. Overall, the included studies varied greatly in scope as well as in the quality and quantity of information reported, but six of the models (Archimedes, CDM [Core Diabetes Model], CRC DES [Cardiff Research Consortium Discrete Event Simulation], DCCT [Diabetes Control and Complications Trial], Sheffield, and EAGLE [Economic Assessment of Glycaemic control and Long-term Effects of diabetes]) were the most rigorous and thoroughly reported. Most models were Markov based, and cohort and microsimulation methods were equally common. All of the more comprehensive models employed microsimulation methods. Model structure varied widely, with the more holistic models providing a comprehensive approach to microvascular and macrovascular events, as well as including adverse events. The majority of studies reported a lifetime horizon, used a payer perspective, and had the capability for sensitivity analysis. Several models have been developed that provide useful

  3. Modeling and control of Type-2 wind turbines for sub-synchronous resonance damping

    International Nuclear Information System (INIS)

    Mancilla-David, Fernando; Domínguez-García, José Luis; De Prada, Mikel; Gomis-Bellmunt, Oriol; Singh, Mohit; Muljadi, Eduard

    2015-01-01

    Highlights: • Dynamic modeling of Type-2 wind turbines for sub-synchronous resonance studies. • Systematic design of a power system stabilizer for Type-2 wind turbines. • Assessment of Type-2 wind turbines to suppress sub-synchronous resonance events. - Abstract: The rapid increase of wind power penetration into power systems around the world has led transmission system operators to enforce stringent grid codes requiring novel functionalities from renewable energy-based power generation. For this reason, there exists a need to asses whether wind turbines (WTs) will comply with such functionalities to ensure power system stability. This paper demonstrates that Type-2 WTs may induce sub-synchronous resonance (SSR) events when connected to a series-compensated transmission line, and with proper control, they may also suppress such events. The paper presents a complete dynamic model tailored to study, via eigenanalysis, SSR events in the presence of Type-2 WTs, and a systematic procedure to design a power system stabilizer using only local and measurable signals. Results are validated through a case study based on the IEEE first benchmark model for SSR studies, as well as with transient computer simulations

  4. Multi-tissue computational modeling analyzes pathophysiology of type 2 diabetes in MKR mice.

    Directory of Open Access Journals (Sweden)

    Amit Kumar

    Full Text Available Computational models using metabolic reconstructions for in silico simulation of metabolic disorders such as type 2 diabetes mellitus (T2DM can provide a better understanding of disease pathophysiology and avoid high experimentation costs. There is a limited amount of computational work, using metabolic reconstructions, performed in this field for the better understanding of T2DM. In this study, a new algorithm for generating tissue-specific metabolic models is presented, along with the resulting multi-confidence level (MCL multi-tissue model. The effect of T2DM on liver, muscle, and fat in MKR mice was first studied by microarray analysis and subsequently the changes in gene expression of frank T2DM MKR mice versus healthy mice were applied to the multi-tissue model to test the effect. Using the first multi-tissue genome-scale model of all metabolic pathways in T2DM, we found out that branched-chain amino acids' degradation and fatty acids oxidation pathway is downregulated in T2DM MKR mice. Microarray data showed low expression of genes in MKR mice versus healthy mice in the degradation of branched-chain amino acids and fatty-acid oxidation pathways. In addition, the flux balance analysis using the MCL multi-tissue model showed that the degradation pathways of branched-chain amino acid and fatty acid oxidation were significantly downregulated in MKR mice versus healthy mice. Validation of the model was performed using data derived from the literature regarding T2DM. Microarray data was used in conjunction with the model to predict fluxes of various other metabolic pathways in the T2DM mouse model and alterations in a number of pathways were detected. The Type 2 Diabetes MCL multi-tissue model may explain the high level of branched-chain amino acids and free fatty acids in plasma of Type 2 Diabetic subjects from a metabolic fluxes perspective.

  5. Bayesian Analysis of a Simple Measurement Model Distinguishing between Types of Information

    Directory of Open Access Journals (Sweden)

    Lira Ignacio

    2015-12-01

    Full Text Available Let a quantity of interest, Y, be modeled in terms of a quantity X and a set of other quantities Z. Suppose that for Z there is type B information, by which we mean that it leads directly to a joint state-of-knowledge probability density function (PDF for that set, without reference to likelihoods. Suppose also that for X there is type A information, which signifies that a likelihood is available. The posterior for X is then obtained by updating its prior with said likelihood by means of Bayes’ rule, where the prior encodes whatever type B information there may be available for X. If there is no such information, an appropriate non-informative prior should be used. Once the PDFs for X and Z have been constructed, they can be propagated through the measurement model to obtain the PDF for Y, either analytically or numerically. But suppose that, at the same time, there is also information of type A, type B or both types together for the quantity Y. By processing such information in the manner described above we obtain another PDF for Y. Which one is right? Should both PDFs be merged somehow? Is there another way of applying Bayes’ rule such that a single PDF for Y is obtained that encodes all existing information? In this paper we examine what we believe should be the proper ways of dealing with such a (not uncommon situation.

  6. Models of Parenting: Implications for Adolescent Well-Being within Different Types of Family Contexts.

    Science.gov (United States)

    Shucksmith, J.; And Others

    1995-01-01

    Examines parenting models and parent-child relationships from early to middle adolescence. Focuses on implications for adolescent functioning, including school integration and psychological well being. Results identify four distinct types of parenting styles characterized by different degrees of acceptance and control of young people's behavior.…

  7. Analysis of recombinant mycobacteria as T helper type 1 vanccines in an allergy challange model

    NARCIS (Netherlands)

    Janssen, R.; Kruisselbrink, A.; Hoogteyling, L.; Lamb, J.R.; Young, D.B.; Thole, J.E.R.

    2001-01-01

    The potential for development of mycobacteria as T helper type 1 (Th1) vaccines capable of induction of Th1 responses to recombinant antigens was explored in a model system based on an immunodominant peptide from house dust mite. Different recombinant mycobacterial preparations were compared for

  8. Novel lean type 2 diabetic rat model using gestational low-protein programming

    Science.gov (United States)

    Type 2 diabetes (T2D) in lean individuals is not well studied and up to 26% of diabetes occurs in these individuals. Although the cause is not well understood, it has been primarily attributed to nutritional issues during early development. Our objective was to develop a lean T2D model using gestati...

  9. Modelling of horn-type loudspeakers for outdoor sound reinforcement systems

    DEFF Research Database (Denmark)

    Schuhmacher, Andreas; Rasmussen, Karsten Bo

    1999-01-01

    -type loudspeakers is made. The agreement between measured and calculated results is very good provided that a sufficient number of modes is included in the simulation. Simulation models of this kind represent one of the first steps towards a CAD tool for outdoor sound reinforcement systems....

  10. Quantum Hall conductivity in a Landau type model with a realistic geometry

    International Nuclear Information System (INIS)

    Chandelier, F.; Georgelin, Y.; Masson, T.; Wallet, J.-C.

    2003-01-01

    In this paper, we revisit some quantum mechanical aspects related to the quantum Hall effect. We consider a Landau type model, paying a special attention to the experimental and geometrical features of quantum Hall experiments. The resulting formalism is then used to compute explicitly the Hall conductivity from a Kubo formula

  11. Method of renormalization potential for one model of Hartree-Fock-Slater type

    CERN Document Server

    Zasorin, Y V

    2002-01-01

    A new method of the potential renormalization for the quasiclassical model of the Hartree-Fock-Slater real potential is proposed. The method makes it possible to easily construct the wave functions and contrary to the majority od similar methods it does not require the knowledge of the real-type potential

  12. AN-type Dunkl operators and new spin Calogero-Sutherland models

    International Nuclear Information System (INIS)

    Finkel, F.; Gomez-Ullate, D.; Gonzalez-Lopez, A.; Rodriguez, M.A.; Zhdanov, R.

    2001-01-01

    A new family of A N -type Dunkl operators preserving a polynomial subspace of finite dimension is constructed. Using a general quadratic combination of these operators and the usual Dunkl operators, several new families of exactly and quasi-exactly solvable quantum spin Calogero-Sutherland models are obtained. These include, in particular, three families of quasi-exactly solvable elliptic spin Hamiltonians. (orig.)

  13. Sulfatide-activated type II NKT cells prevent allergic airway inflammation by inhibiting type I NKT cell function in a mouse model of asthma.

    Science.gov (United States)

    Zhang, Guqin; Nie, Hanxiang; Yang, Jiong; Ding, Xuhong; Huang, Yi; Yu, Hongying; Li, Ruyou; Yuan, Zhuqing; Hu, Suping

    2011-12-01

    Asthma is a common chronic inflammatory disease involving many different cell types. Recently, type I natural killer T (NKT) cells have been demonstrated to play a crucial role in the development of asthma. However, the roles of type II NKT cells in asthma have not been investigated before. Interestingly, type I and type II NKT cells have been shown to have opposing roles in antitumor immunity, antiparasite immunity, and autoimmunity. We hypothesized that sulfatide-activated type II NKT cells could prevent allergic airway inflammation by inhibiting type I NKT cell function in asthma. Strikingly, in our mouse model, activation of type II NKT cells by sulfatide administration and adoptive transfer of sulfatide-activated type II NKT cells result in reduced-inflammation cell infiltration in the lung and bronchoalveolar lavage fluid, decreased levels of IL-4 and IL-5 in the BALF; and decreased serum levels of ovalbumin-specific IgE and IgG1. Furthermore, it is found that the activation of sulfatide-reactive type II NKT cells leads to the functional inactivation of type I NKT cells, including the proliferation and cytokine secretion. Our data reveal that type II NKT cells activated by glycolipids, such as sulfatide, may serve as a novel approach to treat allergic diseases and other disorders characterized by inappropriate type I NKT cell activation.

  14. Developing a theoretical maintenance model for disordered eating in Type 1 diabetes.

    Science.gov (United States)

    Treasure, J; Kan, C; Stephenson, L; Warren, E; Smith, E; Heller, S; Ismail, K

    2015-12-01

    According to the literature, eating disorders are an increasing problem for more than a quarter of people with Type 1 diabetes and they are associated with accentuated diabetic complications. The clinical outcomes in this group when given standard eating disorder treatments are disappointing. The Medical Research Council guidelines for developing complex interventions suggest that the first step is to develop a theoretical model. To review existing literature to build a theoretical maintenance model for disordered eating in people with Type 1 diabetes. The literature in diabetes relating to models of eating disorder (Fairburn's transdiagnostic model and the dual pathway model) and food addiction was examined and assimilated. The elements common to all eating disorder models include weight/shape concern and problems with mood regulation. The predisposing traits of perfectionism, low self-esteem and low body esteem and the interpersonal difficulties from the transdiagnostic model are also relevant to diabetes. The differences include the use of insulin mismanagement to compensate for breaking eating rules and the consequential wide variations in plasma glucose that may predispose to 'food addiction'. Eating disorder symptoms elicit emotionally driven reactions and behaviours from others close to the individual affected and these are accentuated in the context of diabetes. The next stage is to test the assumptions within the maintenance model with experimental medicine studies to facilitate the development of new technologies aimed at increasing inhibitory processes and moderating environmental triggers. © 2015 The Authors. Diabetic Medicine © 2015 Diabetes UK.

  15. Comparison between sparsely distributed memory and Hopfield-type neural network models

    Science.gov (United States)

    Keeler, James D.

    1986-01-01

    The Sparsely Distributed Memory (SDM) model (Kanerva, 1984) is compared to Hopfield-type neural-network models. A mathematical framework for comparing the two is developed, and the capacity of each model is investigated. The capacity of the SDM can be increased independently of the dimension of the stored vectors, whereas the Hopfield capacity is limited to a fraction of this dimension. However, the total number of stored bits per matrix element is the same in the two models, as well as for extended models with higher order interactions. The models are also compared in their ability to store sequences of patterns. The SDM is extended to include time delays so that contextual information can be used to cover sequences. Finally, it is shown how a generalization of the SDM allows storage of correlated input pattern vectors.

  16. Image Restoration Based on the Hybrid Total-Variation-Type Model

    Directory of Open Access Journals (Sweden)

    Baoli Shi

    2012-01-01

    Full Text Available We propose a hybrid total-variation-type model for the image restoration problem based on combining advantages of the ROF model with the LLT model. Since two L1-norm terms in the proposed model make it difficultly solved by using some classically numerical methods directly, we first employ the alternating direction method of multipliers (ADMM to solve a general form of the proposed model. Then, based on the ADMM and the Moreau-Yosida decomposition theory, a more efficient method called the proximal point method (PPM is proposed and the convergence of the proposed method is proved. Some numerical results demonstrate the viability and efficiency of the proposed model and methods.

  17. A Linearized Large Signal Model of an LCL-Type Resonant Converter

    Directory of Open Access Journals (Sweden)

    Hong-Yu Li

    2015-03-01

    Full Text Available In this work, an LCL-type resonant dc/dc converter with a capacitive output filter is modeled in two stages. In the first high-frequency ac stage, all ac signals are decomposed into two orthogonal vectors in a synchronous rotating d–q frame using multi-frequency modeling. In the dc stage, all dc quantities are represented by their average values with average state-space modeling. A nonlinear two-stage model is then created by means of a non-linear link. By aligning the transformer voltage on the d-axis, the nonlinear link can be eliminated, and the whole converter can be modeled by a single set of linear state-space equations. Furthermore, a feedback control scheme can be formed according to the steady-state solutions. Simulation and experimental results have proven that the resulted model is good for fast simulation and state variable estimation.

  18. Inference of type-specific HPV transmissibility, progression and clearance rates: a mathematical modelling approach.

    Directory of Open Access Journals (Sweden)

    Helen C Johnson

    Full Text Available Quantifying rates governing the clearance of Human Papillomavirus (HPV and its progression to clinical disease, together with viral transmissibility and the duration of naturally-acquired immunity, is essential in estimating the impact of vaccination programmes and screening or testing regimes. However, the complex natural history of HPV makes this difficult. We infer the viral transmissibility, rate of waning natural immunity and rates of progression and clearance of infection of 13 high-risk and 2 non-oncogenic HPV types, making use of a number of rich datasets from Sweden. Estimates of viral transmissibility, clearance of initial infection and waning immunity were derived in a Bayesian framework by fitting a susceptible-infectious-recovered-susceptible (SIRS transmission model to age- and type-specific HPV prevalence data from both a cross-sectional study and a randomised controlled trial (RCT of primary HPV screening. The models fitted well, but over-estimated the prevalence of four high-risk types with respect to the data. Three of these types (HPV-33, -35 and -58 are among the most closely related phylogenetically to the most prevalent HPV-16. The fourth (HPV-45 is the most closely related to HPV-18; the second most prevalent type. We suggest that this may be an indicator of cross-immunity. Rates of progression and clearance of clinical lesions were additionally estimated from longitudinal data gathered as part of the same RCT. Our estimates of progression and clearance rates are consistent with the findings of survival analysis studies and we extend the literature by estimating progression and clearance rates for non-16 and non-18 high-risk types. We anticipate that such type-specific estimates will be useful in the parameterisation of further models and in developing our understanding of HPV natural history.

  19. Type-specific human papillomavirus biological features: validated model-based estimates.

    Directory of Open Access Journals (Sweden)

    Iacopo Baussano

    Full Text Available Infection with high-risk (hr human papillomavirus (HPV is considered the necessary cause of cervical cancer. Vaccination against HPV16 and 18 types, which are responsible of about 75% of cervical cancer worldwide, is expected to have a major global impact on cervical cancer occurrence. Valid estimates of the parameters that regulate the natural history of hrHPV infections are crucial to draw reliable projections of the impact of vaccination. We devised a mathematical model to estimate the probability of infection transmission, the rate of clearance, and the patterns of immune response following the clearance of infection of 13 hrHPV types. To test the validity of our estimates, we fitted the same transmission model to two large independent datasets from Italy and Sweden and assessed finding consistency. The two populations, both unvaccinated, differed substantially by sexual behaviour, age distribution, and study setting (screening for cervical cancer or Chlamydia trachomatis infection. Estimated transmission probability of hrHPV types (80% for HPV16, 73%-82% for HPV18, and above 50% for most other types; clearance rates decreasing as a function of time since infection; and partial protection against re-infection with the same hrHPV type (approximately 20% for HPV16 and 50% for the other types were similar in the two countries. The model could accurately predict the HPV16 prevalence observed in Italy among women who were not infected three years before. In conclusion, our models inform on biological parameters that cannot at the moment be measured directly from any empirical data but are essential to forecast the impact of HPV vaccination programmes.

  20. Validation of a model of family caregiver communication types and related caregiver outcomes.

    Science.gov (United States)

    Wittenberg, Elaine; Kravits, Kate; Goldsmith, Joy; Ferrell, Betty; Fujinami, Rebecca

    2017-02-01

    Caring for the family is included as one of the eight domains of quality palliative care, calling attention to the importance of the family system and family communications about cancer during care and treatment of the disease. Previously, a model of family caregiver communication defined four caregiver communication types-Manager, Carrier, Partner, Lone-each with a unique communication pattern. The purpose of the present study was to extend the model of family caregiver communication in cancer care to further understand the impact of family communication burden on caregiving outcomes. This mixed-method study employed fieldnotes from a family caregiver intervention focused on quality of life and self-reported caregiver communication items to identify a specific family caregiver type. Caregiver types were then analyzed using outcome measures on psychological distress, skills preparedness, family inventory of needs, and quality-of-life domains. Corroboration between fieldnotes and self-reported communication for caregivers (n = 21, 16 women, mean age of 53 years) revealed a definitive classification of the four caregiver types (Manager = 6, Carrier = 5, Partner = 6, Lone = 4). Mean scores on self-reported communication items documented different communication patterns congruent with the theoretical framework of the model. Variation in caregiver outcomes measures confirmed the model of family caregiver communication types. Partner and Lone caregivers reported the lowest psychological distress, with Carrier caregivers feeling least prepared and Manager caregivers reporting the lowest physical quality of life. This study illustrates the impact of family communication on caregiving and increases our knowledge and understanding about the role of communication in caregiver burden. The research provides the first evidence-based validation for a family caregiver communication typology and its relationship to caregiver outcomes. Future research is needed to develop and test

  1. Characteristics and model of sandstone type uranium deposit in south of Songliao basin

    International Nuclear Information System (INIS)

    Yu Wenbin; Yu Zhenqing

    2010-01-01

    Through analyzing the uranium deposit tectonic environment, upper cretaceous sequence stratigraphy, depositional system, evolutionary characteristics of sand bodies, the effect of subsequent transformation and the characteristic of uranium deposit, the sandstone type uranium deposit in southern basin is different from typical interlayer oxidation zone sandstone type uranium deposit. The formation and evolution of sandstone-type uranium deposit are controlled by structure fensters; the favorable sedimentary facies type is braided river facies, and the ore body is braided river sand body. The size of uranium deposits is controlled by the local oxidation zone with the characteristics of sandstone type uranium deposit in partial oxidation zone. Uranium ore bodies which distribute in the roof wings of structure fenstes, and occur in gray layers between the upper and lower oxidation zone, showing tabular, and the plate of uranium ore body is controlled by the local oxidation zone. Based on the geological features of sandstone-type uranium deposits, the metallogenic model of local oxidation zones sandstone-type uranium deposits has been set up in the south of Songliao Baisn. (authors)

  2. A model for particle and heat losses by type I edge localized modes

    International Nuclear Information System (INIS)

    Tokar, M Z; Gupta, A; Kalupin, D; Singh, R

    2007-01-01

    A model to estimate the particle and energy losses caused in tokamaks by type I edge localized modes (ELMs) is proposed. This model is based on the assumption that the increase in transport by ELM is due to flows along magnetic field lines perturbed by ballooning-peeling MHD modes. The model reproduces well the experimentally found variation of losses with the plasma collisionality ν*, namely, the weak dependence of the particle loss and significant reduction of the energy loss with increasing ν*. It is argued that the electron parallel heat conductivity is dominating in the energy loss at not very large ν*

  3. Folding-type coupling potentials in the context of the generalized rotation-vibration model

    Science.gov (United States)

    Chamon, L. C.; Morales Botero, D. F.

    2018-03-01

    The generalized rotation-vibration model was proposed in previous works to describe the structure of heavy nuclei. The model was successfully tested in the description of experimental results related to the electron-nucleus elastic and inelastic scattering. In the present work, we consider heavy-ion collisions and assume this model to calculate folding-type coupling potentials for inelastic states, through the corresponding transition densities. As an example, the method is applied to coupled-channel data analyses for the α + 70,72,74,76Ge systems.

  4. Model-based closed-loop glucose control in type 1 diabetes

    DEFF Research Database (Denmark)

    Schmidt, Signe; Boiroux, Dimitri; Duun-Henriksen, Anne Katrine

    2013-01-01

    To improve type 1 diabetes mellitus (T1DM) management, we developed a model predictive control (MPC) algorithm for closed-loop (CL) glucose control based on a linear second-order deterministic-stochastic model. The deterministic part of the model is specified by three patient-specific parameters......: insulin sensitivity factor, insulin action time, and basal insulin infusion rate. The stochastic part is identical for all patients but identified from data from a single patient. Results of the first clinical feasibility test of the algorithm are presented....

  5. A model for plasma evolution in Filipov type plasma focus facilities

    International Nuclear Information System (INIS)

    Siahpoush, V.; Sobhanian, S.; Tafreshi, M. A.; Lamehi, M.

    2003-01-01

    A model is presented in this paper for the evolution of plasma in Filipov type plasma focus facilities. With the help of this model, one can predict some of the main parameters of the produced plasma and obtain the optimized geometrical an physical properties (anode radius and length, gas pressure, capacitance, bank energy etc) for the primary design purposes. The results obtained by this model will be compared with the experimental data obtained from the 90 kJ plasma focus facility D ena

  6. Cosmological-model-parameter determination from satellite-acquired type Ia and IIP Supernova Data

    International Nuclear Information System (INIS)

    Podariu, Silviu; Nugent, Peter; Ratra, Bharat

    2000-01-01

    We examine the constraints that satellite-acquired Type Ia and IIP supernova apparent magnitude versus redshift data will place on cosmological model parameters in models with and without a constant or time-variable cosmological constant lambda. High-quality data which could be acquired in the near future will result in tight constraints on these parameters. For example, if all other parameters of a spatially-flat model with a constant lambda are known, the supernova data should constrain the non-relativistic matter density parameter omega to better than 1 (2, 0.5) at 1 sigma with neutral (worst case, best case) assumptions about data quality

  7. Application of the functional integration method to the Dicke-type models

    International Nuclear Information System (INIS)

    Popov, V.N.; Fedotov, S.A.

    1981-01-01

    The asymptotics of the statistical model sum of the Dicke-type (Z/Z 6 ) is obtained and strictly proved at large N (N is an atomic number; Z is a statistical model sum; Z 0 is a statistical free system sum) using the functional integration method. The model with one bose-field mode is considered. A detailed proof is carried out at T > Tsub(c). An idea of the proof is planned and asymptotic formulae are presented for T < Tsub(c) and in the vicinity of Tsub(c)

  8. Modelling of the Residual Stress State in a new Type of Residual Stress Specimen

    DEFF Research Database (Denmark)

    Jakobsen, Johnny; Andreasen, Jens Henrik

    2014-01-01

    forms the experimental case which is analysed. A FE model of the specimen is used for analysing the curing history and the residual stress build up. The model is validated against experimental strain data which are recorded by a Fibre Brag Grating sensor and good agreement has been achieved.......The paper presents a study on a new type residual stress specimen which is proposed as a simple way to conduct experimental validation for model predictions. A specimen comprising of a steel plate with circular hole embedded into a stack of CSM glass fibre and further infused with an epoxy resin...

  9. Risk score prediction model for dementia in patients with type 2 diabetes.

    Science.gov (United States)

    Li, Chia-Ing; Li, Tsai-Chung; Liu, Chiu-Shong; Liao, Li-Na; Lin, Wen-Yuan; Lin, Chih-Hsueh; Yang, Sing-Yu; Chiang, Jen-Huai; Lin, Cheng-Chieh

    2018-03-30

    No study established a prediction dementia model in the Asian populations. This study aims to develop a prediction model for dementia in Chinese type 2 diabetes patients. This retrospective cohort study included 27,540 Chinese type 2 diabetes patients (aged 50-94 years) enrolled in Taiwan National Diabetes Care Management Program. Participants were randomly allocated into derivation and validation sets at 2:1 ratio. Cox proportional hazards regression models were used to identify risk factors for dementia in the derivation set. Steps proposed by Framingham Heart Study were used to establish a prediction model with a scoring system. The average follow-up was 8.09 years, with a total of 853 incident dementia cases in derivation set. Dementia risk score summed up the individual scores (from 0 to 20). The areas under curve of 3-, 5-, and 10-year dementia risks were 0.82, 0.79, and 0.76 in derivation set and 0.84, 0.80, and 0.75 in validation set, respectively. The proposed score system is the first dementia risk prediction model for Chinese type 2 diabetes patients in Taiwan. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  10. Thermodynamics of spin chains of Haldane–Shastry type and one-dimensional vertex models

    International Nuclear Information System (INIS)

    Enciso, Alberto; Finkel, Federico; González-López, Artemio

    2012-01-01

    We study the thermodynamic properties of spin chains of Haldane–Shastry type associated with the A N−1 root system in the presence of a uniform external magnetic field. To this end, we exactly compute the partition function of these models for an arbitrary finite number of spins. We then show that these chains are equivalent to a suitable inhomogeneous classical Ising model in a spatially dependent magnetic field, generalizing the results of Basu-Mallick et al. for the zero magnetic field case. Using the standard transfer matrix approach, we are able to compute in closed form the free energy per site in the thermodynamic limit. We perform a detailed analysis of the chains’ thermodynamics in a unified way, with special emphasis on the zero field and zero temperature limits. Finally, we provide a novel interpretation of the thermodynamic quantities of spin chains of Haldane–Shastry type as weighted averages of the analogous quantities over an ensemble of classical Ising models. - Highlights: ► Partition function of spin chains of Haldane–Shastry type in magnetic field. ► Equivalence to classical inhomogeneous Ising models. ► Free energy per site, other thermodynamic quantities in thermodynamic limit. ► Zero field, zero temperature limits. ► Thermodynamic equivalence with ensemble of classical Ising models.

  11. Computational Software to Fit Seismic Data Using Epidemic-Type Aftershock Sequence Models and Modeling Performance Comparisons

    Science.gov (United States)

    Chu, A.

    2016-12-01

    Modern earthquake catalogs are often analyzed using spatial-temporal point process models such as the epidemic-type aftershock sequence (ETAS) models of Ogata (1998). My work implements three of the homogeneous ETAS models described in Ogata (1998). With a model's log-likelihood function, my software finds the Maximum-Likelihood Estimates (MLEs) of the model's parameters to estimate the homogeneous background rate and the temporal and spatial parameters that govern triggering effects. EM-algorithm is employed for its advantages of stability and robustness (Veen and Schoenberg, 2008). My work also presents comparisons among the three models in robustness, convergence speed, and implementations from theory to computing practice. Up-to-date regional seismic data of seismic active areas such as Southern California and Japan are used to demonstrate the comparisons. Data analysis has been done using computer languages Java and R. Java has the advantages of being strong-typed and easiness of controlling memory resources, while R has the advantages of having numerous available functions in statistical computing. Comparisons are also made between the two programming languages in convergence and stability, computational speed, and easiness of implementation. Issues that may affect convergence such as spatial shapes are discussed.

  12. Extended Lipkin-type models with residual proton-neutron interaction

    International Nuclear Information System (INIS)

    Stoica, S.

    1999-01-01

    Extended Lipkin-Meshkov-Glick (LMG) models for testing the Random Phase Approximation (RPA) and proton-neutron Random Phase Approximation (pnRPA) methods are developed taking into account explicitly the proton and neutron degrees of freedom. First, an extended LMG model for testing RPA is developed. The proton and neutron Hamiltonians are taken to be of the LMG form and, in addition, a residual proton-neutron interaction is included. Exact solutions in a SU(2) x SU(2) basis as well as the RPA solutions for the energy spectrum of the model Hamiltonian are obtained. Then, the behaviour of the first collective excited state is studied as a function of the interaction parameters of the model using the exact and RPA methods. Secondly, an extended LMG model for testing pnRPA method is developed. Besides the proton and neutron single particle terms two types of residual proton-neutron interactions, one simulating a particle-particle and the other a particle-hole interaction, are included in the model Hamiltonian, so that the model is exactly solvable in an isospin SU(2) x SU(2) basis. The exact and pnRPA spectra of the model Hamiltonian are calculated as a function of the model parameters and compared to each other. Furthermore, charge-changing operators simulating a nuclear beta decay and their action on eigenfunctions of the model Hamiltonian are defined, and transition amplitude of them are calculated using exact and pnRPA wave functions. The best agreement between the exact RPA-type calculations for spectra and transitions, was obtained when the correlated RPA ground state, instead of the uncorrelated HF ground state was employed and when both kinds of residual interactions (i.e. like- and unlike-particle two-body interactions) are included in the model Hamiltonians. (author)

  13. Deformed type 0A matrix model and super-Liouville theory for fermionic black holes

    International Nuclear Information System (INIS)

    Ahn, Changrim; Kim, Chanju; Park, Jaemo; Suyama, Takao; Yamamoto, Masayoshi

    2006-01-01

    We consider a c-circumflex = 1 model in the fermionic black hole background. For this purpose we consider a model which contains both the N 1 and the N = 2 super-Liouville interactions. We propose that this model is dual to a recently proposed type 0A matrix quantum mechanics model with vortex deformations. We support our conjecture by showing that non-perturbative corrections to the free energy computed by both the matrix model and the super-Liouville theories agree exactly by treating the N = 2 interaction as a small perturbation. We also show that a two-point function on sphere calculated from the deformed type 0A matrix model is consistent with that of the N = 2 super-Liouville theory when the N = 1 interaction becomes small. This duality between the matrix model and super-Liouville theories leads to a conjecture for arbitrary n-point correlation functions of the N = 1 super-Liouville theory on the sphere

  14. Implementation of IEC Generic Models of Type 1 Wind Turbine Generator in DIgSILENT PowerFactory

    Institute of Scientific and Technical Information of China (English)

    Haoran ZHAO; Qiuwei WU; Ioannis MARGARIS; Poul S(O)RENSEN

    2013-01-01

    The implementation method for the International Electrotechnical Commission (IEC) generic models of Type 1 wind turbine generator (WTG) in DIgSILENT PowerFactory is presented.The following items are described,i.e.model structure,model blocks and how to implement these blocks in the PowerFactory environment.Case studies under both normal and fault conditions are done with the implemented IEC generic models of Type 1 WTG,and dynamic responses are captured and analyzed.The case study results show that the IEC generic models of Type 1 WTG can correctly represent the performances of Type 1 WTG under both normal and fault conditions.

  15. Late-time behaviour of the tilted Bianchi type VIh models

    Science.gov (United States)

    Hervik, S.; van den Hoogen, R. J.; Lim, W. C.; Coley, A. A.

    2007-08-01

    We study tilted perfect fluid cosmological models with a constant equation of state parameter in spatially homogeneous models of Bianchi type VIh using dynamical systems methods and numerical experimentation, with an emphasis on their future asymptotic evolution. We determine all of the equilibrium points of the type VIh state space (which correspond to exact self-similar solutions of the Einstein equations, some of which are new), and their stability is investigated. We find that there are vacuum plane-wave solutions that act as future attractors. In the parameter space, a 'loophole' is shown to exist in which there are no stable equilibrium points. We then show that a Hopf-bifurcation can occur resulting in a stable closed orbit (which we refer to as the Mussel attractor) corresponding to points both inside the loophole and points just outside the loophole; in the former case the closed curves act as late-time attractors while in the latter case these attracting curves will co-exist with attracting equilibrium points. In the special Bianchi type III case, centre manifold theory is required to determine the future attractors. Comprehensive numerical experiments are carried out to complement and confirm the analytical results presented. We note that the Bianchi type VIh case is of particular interest in that it contains many different subcases which exhibit many of the different possible future asymptotic behaviours of Bianchi cosmological models.

  16. Different developmental trajectories across feature types support a dynamic field model of visual working memory development.

    Science.gov (United States)

    Simmering, Vanessa R; Miller, Hilary E; Bohache, Kevin

    2015-05-01

    Research on visual working memory has focused on characterizing the nature of capacity limits as "slots" or "resources" based almost exclusively on adults' performance with little consideration for developmental change. Here we argue that understanding how visual working memory develops can shed new light onto the nature of representations. We present an alternative model, the Dynamic Field Theory (DFT), which can capture effects that have been previously attributed either to "slot" or "resource" explanations. The DFT includes a specific developmental mechanism to account for improvements in both resolution and capacity of visual working memory throughout childhood. Here we show how development in the DFT can account for different capacity estimates across feature types (i.e., color and shape). The current paper tests this account by comparing children's (3, 5, and 7 years of age) performance across different feature types. Results showed that capacity for colors increased faster over development than capacity for shapes. A second experiment confirmed this difference across feature types within subjects, but also showed that the difference can be attenuated by testing memory for less familiar colors. Model simulations demonstrate how developmental changes in connectivity within the model-purportedly arising through experience-can capture differences across feature types.

  17. New spin Calogero-Sutherland models related to BN-type Dunkl operators

    International Nuclear Information System (INIS)

    Finkel, F.; Gomez-Ullate, D.; Gonzalez-Lopez, A.; Rodriguez, M.A.; Zhdanov, R.

    2001-01-01

    We construct several new families of exactly and quasi-exactly solvable BC N -type Calogero-Sutherland models with internal degrees of freedom. Our approach is based on the introduction of a new family of Dunkl operators of B N type which, together with the original B N -type Dunkl operators, are shown to preserve certain polynomial subspaces of finite dimension. We prove that a wide class of quadratic combinations involving these three sets of Dunkl operators always yields a spin Calogero-Sutherland model, which is (quasi-)exactly solvable by construction. We show that all the spin Calogero-Sutherland models obtainable within this framework can be expressed in a unified way in terms of a Weierstrass ζ function with suitable half-periods. This provides a natural spin counterpart of the well-known general formula for a scalar completely integrable potential of BC N type due to Olshanetsky and Perelomov. As an illustration of our method, we exactly compute several energy levels and their corresponding wavefunctions of an elliptic quasi-exactly solvable potential for two and three particles of spin 1/2

  18. Modeling and forecasting crude oil markets using ARCH-type models

    International Nuclear Information System (INIS)

    Cheong, Chin Wen

    2009-01-01

    This study investigates the time-varying volatility of two major crude oil markets, the West Texas Intermediate (WTI) and Europe Brent. A flexible autoregressive conditional heteroskedasticity (ARCH) model is used to take into account the stylized volatility facts such as clustering volatility, asymmetric news impact and long memory volatility among others. The empirical results indicate that the intensity of long-persistence volatility in the WTI is greater than in the Brent. It is also found that for the WTI, the appreciation and depreciation shocks of the WTI have similar impact on the resulting volatility. However, a leverage effect is found in Brent. Although both the estimation and diagnostic evaluations are in favor of an asymmetric long memory ARCH model, only the WTI models provide superior in the out-of-sample forecasts. On the other hand, from the empirical out-of-sample forecasts, it appears that the simplest parsimonious generalized ARCH provides the best forecasted evaluations for the Brent crude oil data.

  19. Modeling and forecasting crude oil markets using ARCH-type models

    Energy Technology Data Exchange (ETDEWEB)

    Cheong, Chin Wen [Research Centre of Mathematical Sciences, Faculty of Information Technology, Multimedia University, 63100 Cyberjaya, Selangor (Malaysia)

    2009-06-15

    This study investigates the time-varying volatility of two major crude oil markets, the West Texas Intermediate (WTI) and Europe Brent. A flexible autoregressive conditional heteroskedasticity (ARCH) model is used to take into account the stylized volatility facts such as clustering volatility, asymmetric news impact and long memory volatility among others. The empirical results indicate that the intensity of long-persistence volatility in the WTI is greater than in the Brent. It is also found that for the WTI, the appreciation and depreciation shocks of the WTI have similar impact on the resulting volatility. However, a leverage effect is found in Brent. Although both the estimation and diagnostic evaluations are in favor of an asymmetric long memory ARCH model, only the WTI models provide superior in the out-of-sample forecasts. On the other hand, from the empirical out-of-sample forecasts, it appears that the simplest parsimonious generalized ARCH provides the best forecasted evaluations for the Brent crude oil data. (author)

  20. A novel TRNSYS type for short-term borehole heat exchanger simulation: B2G model

    International Nuclear Information System (INIS)

    De Rosa, Mattia; Ruiz-Calvo, Félix; Corberán, José M.; Montagud, Carla; Tagliafico, Luca A.

    2015-01-01

    Highlights: • A novel dynamic borehole heat exchanger model is presented. • Theoretical approach for model parameters calculation is described. • The short-term model is validated against experimental data of a real GSHP. • Strong dynamic conditions due to the ON–OFF regulation are investigated. - Abstract: Models of ground source heat pump (GSHP) systems are used as an aid for the correct design and optimization of the system. For this purpose, it is necessary to develop models which correctly reproduce the dynamic thermal behavior of each component in a short-term basis. Since the borehole heat exchanger (BHE) is one of the main components, special attention should be paid to ensuring a good accuracy on the prediction of the short-term response of the boreholes. The BHE models found in literature which are suitable for short-term simulations usually present high computational costs. In this work, a novel TRNSYS type implementing a borehole-to-ground (B2G) model, developed for modeling the short-term dynamic performance of a BHE with low computational cost, is presented. The model has been validated against experimental data from a GSHP system located at Universitat Politècnica de València, Spain. Validation results show the ability of the model to reproduce the short-term behavior of the borehole, both for a step-test and under normal operating conditions

  1. Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation

    Directory of Open Access Journals (Sweden)

    Haitao Zhu

    2014-01-01

    Full Text Available Islet transplantation is an attractive treatment of type 1 diabetes mellitus (T1DM. Animal models of diabetes mellitus (DM contribute a lot to the experimental studies of islet transplantation and to evaluations of isolated islet grafts for future clinical applications. Diabetic nonhuman primates (NHPs represent the suitable models of DMs to better evaluate the effectiveness of islet transplantation, to assess new strategies for controlling blood glucose (BG, relieving immune rejection, or prolonging islet survival, and eventually to translate the preclinical data into tangible clinical practice. This review introduces some NHP models of DM, clarifies why and how the models should be used, and elucidates the usefulness and limitations of the models in islet transplantation.

  2. Modeling the failure data of a repairable equipment with bathtub type failure intensity

    International Nuclear Information System (INIS)

    Pulcini, G.

    2001-01-01

    The paper deals with the reliability modeling of the failure process of large and complex repairable equipment whose failure intensity shows a bathtub type non-monotonic behavior. A non-homogeneous Poisson process arising from the superposition of two power law processes is proposed, and the characteristics and mathematical details of the proposed model are illustrated. A graphical approach is also presented, which allows to determine whether the proposed model can adequately describe a given failure data. A graphical method for obtaining crude but easy estimates of the model parameters is then illustrated, as well as more accurate estimates based on the maximum likelihood method are provided. Finally, two numerical applications are given to illustrate the proposed model and the estimation procedures

  3. The female gametophyte: an emerging model for cell type-specific systems biology in plant development

    Directory of Open Access Journals (Sweden)

    Marc William Schmid

    2015-11-01

    Full Text Available Systems biology, a holistic approach describing a system emerging from the interactions of its molecular components, critically depends on accurate qualitative determination and quantitative measurements of these components. Development and improvement of large-scale profiling methods (omics now facilitates comprehensive measurements of many relevant molecules. For multicellular organisms, such as animals, fungi, algae, and plants, the complexity of the system is augmented by the presence of specialized cell types and organs, and a complex interplay within and between them. Cell type-specific analyses are therefore crucial for the understanding of developmental processes and environmental responses. This review first gives an overview of current methods used for large-scale profiling of specific cell types exemplified by recent advances in plant biology. The focus then lies on suitable model systems to study plant development and cell type specification. We introduce the female gametophyte of flowering plants as an ideal model to study fundamental developmental processes. Moreover, the female reproductive lineage is of importance for the emergence of evolutionary novelties such as an unequal parental contribution to the tissue nurturing the embryo or the clonal production of seeds by asexual reproduction (apomixis. Understanding these processes is not only interesting from a developmental or evolutionary perspective, but bears great potential for further crop improvement and the simplification of breeding efforts. We finally highlight novel methods, which are already available or which will likely soon facilitate large-scale profiling of the specific cell types of the female gametophyte in both model and non-model species. We conclude that it may take only few years until an evolutionary systems biology approach toward female gametogenesis may decipher some of its biologically most interesting and economically most valuable processes.

  4. Analysis and model testing of a Super Tiger Type B waste transport system in accident environments

    International Nuclear Information System (INIS)

    May, R.A.; Yoshimura, H.R.; Romesberg, L.E.; Joseph, B.J.

    1980-01-01

    Sandia National Laboratories is investigating the response of a Type B packaging containing drums of contact-handled transuranic waste (CH-TRU) as a part of a program to evaluate the adequacy of experimental and analytical methods for assessing the safety of waste transport systems in accident environments. A US NRC certified Type B package known as the Super Tiger was selected for the study. This overpack consists of inner and outer steel shells separated by rigid polyurethane foam and can be used for either highway or rail transportation. Tests using scale models of the vehicular system are being conducted in conjunction with computer analyses

  5. Mathematical model of snake-type multi-directional wave generation

    Science.gov (United States)

    Muarif; Halfiani, Vera; Rusdiana, Siti; Munzir, Said; Ramli, Marwan

    2018-01-01

    Research on extreme wave generation is one intensive research on water wave study because the fact that the occurrence of this wave in the ocean can cause serious damage to the ships and offshore structures. One method to be used to generate the wave is self-correcting. This method controls the signal on the wavemakers in a wave tank. Some studies also consider the nonlinear wave generation in a wave tank by using numerical approach. Study on wave generation is essential in the effectiveness and efficiency of offshore structure model testing before it can be operated in the ocean. Generally, there are two types of wavemakers implemented in the hydrodynamic laboratory, piston-type and flap-type. The flap-type is preferred to conduct a testing to a ship in deep water. Single flap wavemaker has been explained in many studies yet snake-type wavemaker (has more than one flap) is still a case needed to be examined. Hence, the formulation in controlling the wavemaker need to be precisely analyzed such that the given input can generate the desired wave in the space-limited wave tank. By applying the same analogy and methodhology as the previous study, this article represents multi-directional wave generation by implementing snake-type wavemakers.

  6. Analysis of crashes using FE vehicle models. Relations between vehicle types and crash characteristics; Yugen yoso model wo mochiita sharyo no shototsu kaiseki. Sharyo type to shototsu tokusei

    Energy Technology Data Exchange (ETDEWEB)

    Takatori, O. [Japan Automobile Research Institute Inc., Tsukuba (Japan)

    2000-01-01

    The objective of this study is to analyze the crash characteristics of vehicles under the condition of real-world accidents. This paper pays attention to the differences in the crash characteristics of a vehicle colliding with a vehicle which is a different type. Vehicles on the market can be divided broadly into two vehicle structures, monocoque structure and frame structure. Monocoque structure is mainly used for passenger vehicles and frame structure is for recreational vehicles (RV). In recent years, RV has been a large seller on the market. So accidents between passenger vehicles and a RVs occur frequently. The analysis of experimental data and computer simulation, which is predicated on the experimental data, was carried out for this study. In the analysis of experimental data, barrier force data from the New Car Assessment Program (NCAP) were analyzed. The FE passenger vehicle model which is based on systematic validation tests was used for the computer simulation of car-to-car collisions. (author)

  7. Satellite image simulations for model-supervised, dynamic retrieval of crop type and land use intensity

    Science.gov (United States)

    Bach, H.; Klug, P.; Ruf, T.; Migdall, S.; Schlenz, F.; Hank, T.; Mauser, W.

    2015-04-01

    To support food security, information products about the actual cropping area per crop type, the current status of agricultural production and estimated yields, as well as the sustainability of the agricultural management are necessary. Based on this information, well-targeted land management decisions can be made. Remote sensing is in a unique position to contribute to this task as it is globally available and provides a plethora of information about current crop status. M4Land is a comprehensive system in which a crop growth model (PROMET) and a reflectance model (SLC) are coupled in order to provide these information products by analyzing multi-temporal satellite images. SLC uses modelled surface state parameters from PROMET, such as leaf area index or phenology of different crops to simulate spatially distributed surface reflectance spectra. This is the basis for generating artificial satellite images considering sensor specific configurations (spectral bands, solar and observation geometries). Ensembles of model runs are used to represent different crop types, fertilization status, soil colour and soil moisture. By multi-temporal comparisons of simulated and real satellite images, the land cover/crop type can be classified in a dynamically, model-supervised way and without in-situ training data. The method is demonstrated in an agricultural test-site in Bavaria. Its transferability is studied by analysing PROMET model results for the rest of Germany. Especially the simulated phenological development can be verified on this scale in order to understand whether PROMET is able to adequately simulate spatial, as well as temporal (intra- and inter-season) crop growth conditions, a prerequisite for the model-supervised approach. This sophisticated new technology allows monitoring of management decisions on the field-level using high resolution optical data (presently RapidEye and Landsat). The M4Land analysis system is designed to integrate multi-mission data and is

  8. Analytical calculation of detailed model parameters of cast resin dry-type transformers

    International Nuclear Information System (INIS)

    Eslamian, M.; Vahidi, B.; Hosseinian, S.H.

    2011-01-01

    Highlights: → In this paper high frequency behavior of cast resin dry-type transformers was simulated. → Parameters of detailed model were calculated using analytical method and compared with FEM results. → A lab transformer was constructed in order to compare theoretical and experimental results. -- Abstract: Non-flammable characteristic of cast resin dry-type transformers make them suitable for different kind of usages. This paper presents an analytical method of how to obtain parameters of detailed model of these transformers. The calculated parameters are compared and verified with the corresponding FEM results and if it was necessary, correction factors are introduced for modification of the analytical solutions. Transient voltages under full and chopped test impulses are calculated using the obtained detailed model. In order to validate the model, a setup was constructed for testing on high-voltage winding of cast resin dry-type transformer. The simulation results were compared with the experimental data measured from FRA and impulse tests.

  9. Predicting the Types of Ion Channel-Targeted Conotoxins Based on AVC-SVM Model.

    Science.gov (United States)

    Xianfang, Wang; Junmei, Wang; Xiaolei, Wang; Yue, Zhang

    2017-01-01

    The conotoxin proteins are disulfide-rich small peptides. Predicting the types of ion channel-targeted conotoxins has great value in the treatment of chronic diseases, epilepsy, and cardiovascular diseases. To solve the problem of information redundancy existing when using current methods, a new model is presented to predict the types of ion channel-targeted conotoxins based on AVC (Analysis of Variance and Correlation) and SVM (Support Vector Machine). First, the F value is used to measure the significance level of the feature for the result, and the attribute with smaller F value is filtered by rough selection. Secondly, redundancy degree is calculated by Pearson Correlation Coefficient. And the threshold is set to filter attributes with weak independence to get the result of the refinement. Finally, SVM is used to predict the types of ion channel-targeted conotoxins. The experimental results show the proposed AVC-SVM model reaches an overall accuracy of 91.98%, an average accuracy of 92.17%, and the total number of parameters of 68. The proposed model provides highly useful information for further experimental research. The prediction model will be accessed free of charge at our web server.

  10. Public health program planning logic model for community engaged type 2 diabetes management and prevention.

    Science.gov (United States)

    West, Joseph F

    2014-02-01

    Diabetes remains a growing epidemic with widening health inequity gaps in disease management, self-management knowledge, access to care and outcomes. Yet there is a paucity of evaluation tools for community engaged interventions aimed at closing the gaps and improving health. The Guide to Community Preventive Services (the Community Guide) developed by the Task Force on Community Preventive Services (the Task Force) at the Centers for Disease Control and Prevention (CDC) recommends two healthcare system level interventions, case management interventions and disease management programs, to improve glycemic control. However, as a public health resource guide for diabetes interventions a model for community engagement is a glaringly absent component of the Community Guide recommendations. In large part there are few evidence-based interventions featuring community engagement as a practice and system-level focus of chronic disease and Type 2 diabetes management. The central argument presented in this paper is that the absence of these types of interventions is due to the lack of tools for modeling and evaluating such interventions, especially among disparate and poor populations. A conceptual model emphasizing action-oriented micro-level community engagement is needed to complement the Community Guide and serve as the basis for testing and evaluation of these kinds of interventions. A unique logic model advancing the Community Guide diabetes recommendations toward measureable and sustainable community engagement for improved Type 2 diabetes outcomes is presented. Copyright © 2013 Elsevier Ltd. All rights reserved.

  11. Calibrating a forest landscape model to simulate frequent fire in Mediterranean-type shrublands

    Science.gov (United States)

    Syphard, A.D.; Yang, J.; Franklin, J.; He, H.S.; Keeley, J.E.

    2007-01-01

    In Mediterranean-type ecosystems (MTEs), fire disturbance influences the distribution of most plant communities, and altered fire regimes may be more important than climate factors in shaping future MTE vegetation dynamics. Models that simulate the high-frequency fire and post-fire response strategies characteristic of these regions will be important tools for evaluating potential landscape change scenarios. However, few existing models have been designed to simulate these properties over long time frames and broad spatial scales. We refined a landscape disturbance and succession (LANDIS) model to operate on an annual time step and to simulate altered fire regimes in a southern California Mediterranean landscape. After developing a comprehensive set of spatial and non-spatial variables and parameters, we calibrated the model to simulate very high fire frequencies and evaluated the simulations under several parameter scenarios representing hypotheses about system dynamics. The goal was to ensure that observed model behavior would simulate the specified fire regime parameters, and that the predictions were reasonable based on current understanding of community dynamics in the region. After calibration, the two dominant plant functional types responded realistically to different fire regime scenarios. Therefore, this model offers a new alternative for simulating altered fire regimes in MTE landscapes. ?? 2007 Elsevier Ltd. All rights reserved.

  12. Hanseníase: subnotificação de casos em Fortaleza - Ceará, Brasil Leprosy: underreported cases in Fortaleza - Ceará, Brazil

    Directory of Open Access Journals (Sweden)

    Mônica Cardoso Façanha

    2006-08-01

    Full Text Available FUNDAMENTO: Visando à eliminação da hanseníase como problema de saúde pública no Brasil, o Ministério da Saúde tem como meta alcançar taxa de prevalência de menos de 1 caso/10.000 habitantes, estimulando o diagnóstico e tratamento dos casos e reduzindo a disseminação da doença. O Sistema de Informação de Agravos de Notificação (SINAN foi designado para acompanhar o cumprimento dessa meta. OBJETIVO: Verificar a proporção dos casos de hanseníase diagnosticados nas unidades de saúde do município de Fortaleza que foi notificada ao SINAN. MÉTODOS: Foi feita a identificação dos casos diagnosticados e registrados nas unidades de saúde e notificados à Secretaria Municipal de Saúde de Fortaleza (SMSF entre 2002 e 2004 por meio da comparação nominal entre os registros locais e os registros do SINAN. RESULTADOS: Foram identificados e resgatados para o SINAN 411 casos que haviam sido diagnosticados e não notificados (17,5% do total informado de 15 (64% das unidades que informaram pelo menos um caso no período. Cerca 342 casos constavam nos livros e estavam notificados no banco de dados do SINAN das unidades de atendimento, mas não compunham o banco de dados do SINAN da SMSF. CONCLUSÕES: Constatou-se subnotificação de 14,9% dos casos detectados, fato que precisa ser prevenido para que os indicadores reflitam a real freqüência dos casos no município.BACKGROUND: To eliminate leprosy as a public health problem in Brazil, the Ministry of Health aims to achieve a prevalence rate of less than 1.0 case/10,000 inhabitants, encouraging diagnosis and treatment of patients and reducing dissemination of the disease. The National Disease Notification System (SINAN is in charge of verify the elimination plan results. OBJECTIVE: To verify the proportion of leprosy cases diagnosed and reported to SINAN by health centers of the city of Fortaleza, in Ceará, Northeastern region of Brazil. METHODS: Comparison between cases registered in

  13. Analysis and model testing of Super Tiger Type B packaging in accident environments

    International Nuclear Information System (INIS)

    Yoshimura, H.R.; Romesberg, L.E.; May, R.A.; Joseph, B.J.

    1980-01-01

    Based on previous scale model test results with more rigid systems and the subsystem tests on drums, it is believed that the scaled models realistically replicate full scale system behavior. Future work will be performed to obtain improved stiffness data on the Type A containers. These data will be incorporated into the finite element model, and improved correlation with the test results is expected. Review of the scale model transport system test results indicated that the method of attachment of the Super Tiger to the trailer was the primary cause for detachment of the outer door during the one-eighth scale grade-crossing test. Although the container seal on the scale model of Super Tiger was not adequately modeled to provide a leak-tight seal, loss of the existing seal in a full scale test can be inferred from the results of the one-quarter scale model grade-crossing test. In each test, approximately two-thirds of the model drums were estimated to have deformed sufficiently to predict loss of drum head closure seal, with several partially losing their contents within the overpack. In no case were drums ejected from the overpack, nor was there evidence of material loss in excess of the amount assumed in the WIPP EIS from any of the Super Tiger models tested. 9 figures

  14. Population pharmacokinetic modeling of glibenclamide in poorly controlled South African type 2 diabetic subjects

    Directory of Open Access Journals (Sweden)

    Rambiritch V

    2016-07-01

    Full Text Available Virendra Rambiritch,1 Poobalan Naidoo,2 Breminand Maharaj,1 Goonaseelan Pillai3 1University of KwaZulu-Natal, Durban, 2Department of Internal Medicine, RK Khan Regional Hospital, Chatsworth, South Africa; 3Novartis Pharma AG, Basel, Switzerland Aim: The aim of this study was to describe the pharmacokinetics (PK of glibenclamide in poorly controlled South African type 2 diabetic subjects using noncompartmental and model-based methods. Methods: A total of 24 subjects with type 2 diabetes were administered increasing doses (0 mg/d, 2.5 mg/d, 5 mg/d, 10 mg/d, and 20 mg/d of glibenclamide daily at 2-week intervals. Plasma glibenclamide, glucose, and insulin determinations were performed. Blood sampling times were 0 minute, 30 minutes, 60 minutes, 90 minutes, and 120 minutes (post breakfast sampling and 240 minutes, 270 minutes, 300 minutes, 330 minutes, 360 minutes, and 420 minutes (post lunch sampling on days 14, 28, 42, 56, and 70 for doses of 0 mg, 2.5 mg, 5.0 mg, 10 mg, and 20 mg, respectively. Blood sampling was performed after the steady state was reached.  A total of 24 individuals in the data set contributed to a total of 841 observation records. The PK was analyzed using noncompartmental analysis methods, which were implemented in WinNonLin®, and population PK analysis using NONMEM®. Glibenclamide concentration data were log transformed prior to fitting. Results: A two-compartmental disposition model was selected after evaluating one-, two-, and three-compartmental models to describe the time course of glibenclamide plasma concentration data. The one-compartment model adequately described the data; however, the two-compartment model provided a better fit. The three-compartment model failed to achieve successful convergence. A more complex model, to account for enterohepatic recirculation that was observed in the data, was unsuccessful. Conclusion: In South African diabetic subjects, glibenclamide demonstrates linear PK and was best

  15. Dealing with time-varying recruitment and length in Hill-type muscle models.

    Science.gov (United States)

    Hamouda, Ahmed; Kenney, Laurence; Howard, David

    2016-10-03

    Hill-type muscle models are often used in muscle simulation studies and also in the design and virtual prototyping of functional electrical stimulation systems. These models have to behave in a sufficiently realistic manner when recruitment level and contractile element (CE) length change continuously. For this reason, most previous models have used instantaneous CE length in the muscle׳s force vs. length (F-L) relationship, but thereby neglect the instability problem on the descending limb (i.e. region of negative slope) of the F-L relationship. Ideally CE length at initial recruitment should be used but this requires a multiple-motor-unit muscle model to properly account for different motor-units having different initial lengths when recruited. None of the multiple-motor-unit models reported in the literature have used initial CE length in the muscle׳s F-L relationship, thereby also neglecting the descending limb instability problem. To address the problem of muscle modelling for continuously varying recruitment and length, and hence different values of initial CE length for different motor-units, a new multiple-motor-unit muscle model is presented which considers the muscle to comprise 1000 individual Hill-type virtual motor-units, which determine the total isometric force. Other parts of the model (F-V relationship and passive elements) are not dependent on the initial CE length and, therefore, they are implemented for the muscle as a whole rather than for the individual motor-units. The results demonstrate the potential errors introduced by using a single-motor-unit model and also the instantaneous CE length in the F-L relationship, both of which are common in FES control studies. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Asteroseismic modelling of the solar-type subgiant star β Hydri

    Science.gov (United States)

    Brandão, I. M.; Doğan, G.; Christensen-Dalsgaard, J.; Cunha, M. S.; Bedding, T. R.; Metcalfe, T. S.; Kjeldsen, H.; Bruntt, H.; Arentoft, T.

    2011-03-01

    Context. Comparing models and data of pulsating stars is a powerful way to understand the stellar structure better. Moreover, such comparisons are necessary to make improvements to the physics of the stellar models, since they do not yet perfectly represent either the interior or especially the surface layers of stars. Because β Hydri is an evolved solar-type pulsator with mixed modes in its frequency spectrum, it is very interesting for asteroseismic studies. Aims: The goal of the present work is to search for a representative model of the solar-type star β Hydri, based on up-to-date non-seismic and seismic data. Methods: We present a revised list of frequencies for 33 modes, which we produced by analysing the power spectrum of the published observations again using a new weighting scheme that minimises the daily sidelobes. We ran several grids of evolutionary models with different input parameters and different physics, using the stellar evolutionary code ASTEC. For the models that are inside the observed error box of β Hydri, we computed their frequencies with the pulsation code ADIPLS. We used two approaches to find the model that oscillates with the frequencies that are closest to the observed frequencies of β Hydri: (i) we assume that the best model is the one that reproduces the star's interior based on the radial oscillation frequencies alone, to which we have applied the correction for the near-surface effects; (ii) we assume that the best model is the one that produces the lowest value of the chi-square (χ2), i.e. that minimises the difference between the observed frequencies of all available modes and the model predictions, after all model frequencies are corrected for near-surface effects. Results: We show that after applying a correction for near-surface effects to the frequencies of the best models, we can reproduce the observed modes well, including those that have mixed mode character. The model that gives the lowest value of the χ2 is a post

  17. A model for the thermodynamic analysis in a batch type fluidized bed dryer

    International Nuclear Information System (INIS)

    Özahi, Emrah; Demir, Hacımurat

    2013-01-01

    An original model for thermodynamic analysis of a batch type fluidized bed dryer is proposed herein considering two separate systems comprised of drying air medium as a control volume and particles to be dried as a control mass. By means of the proposed model, energetic and exergetic analyses of a drying column of a batch type fluidized bed dryer are carried out as an original contribution to literature since there is no such like model in which the analyses are performed considering two separate systems. The energetic efficiencies evaluated by means of the proposed model using the data in literature are compared with those in literature and a good conformity is satisfied with an acceptable error margin of ±9%. A new correlation is also developed with a mean deviation of ±10% in order to evaluate the energetic efficiency for not only corn drying process but also drying processes of other particles at inlet air temperature of 50 °C. Effects of air mass flow rate, mass of particle and ambient temperature on energetic and exergetic efficiencies are analyzed and some concluding remarks are highlighted for further studies. - Highlights: • Energetic and exergetic analyses of a batch type fluidized bed dryer are developed. • An original model is proposed for thermodynamic analyses in a fluidized bed dryer. • The proposed model is compared with the data in literature with an accuracy of ±9%. • Effect of air mass flow rate is more significant than that of ambient temperature. • Effect of mass of particle is more significant than that of ambient temperature

  18. Numerical modeling and design of a disk-type rotating permanent magnet induction pump

    Energy Technology Data Exchange (ETDEWEB)

    Koroteeva, E., E-mail: koroteeva@physics.msu.ru [Institute of Physics of University of Latvia, Salaspils 2169 (Latvia); Lomonosov Moscow State University, Moscow 119991 (Russian Federation); Ščepanskis, M. [Laboratory for Mathematical Modelling of Environmental and Technological Processes, University of Latvia, Rīga 1002 (Latvia); Bucenieks, I.; Platacis, E. [Institute of Physics of University of Latvia, Salaspils 2169 (Latvia)

    2016-05-15

    Highlights: • The design and performance of a disk-type induction pump are described. • A 3D numerical model based on an iterative coupling between EM and hydrodynamic solvers is developed. • The model is verified by comparing with the experiments in a Pb-Bi loop facility. • The suggestions are given to estimate the pump performance in a Pb-Li loop at high pressures. - Abstract: Electromagnetic induction pumps with rotating permanent magnets appear to be the most promising devices to transport liquid metals in high-temperature applications. Here we present a numerical methodology to simulate the operation of one particular modification of these types of pumps: a disk-type induction pump. The numerical model allows for the calculation and analysis of the flow parameters, including the pressure–flow rate characteristics of the pump. The simulations are based on an iterative fully coupled scheme for electromagnetic and hydrodynamic solvers. The developed model is verified by comparing with experimental data obtained using a Pb-Bi loop test facility, for pressures up to 4 bar and flow rates up to 9 kg/s. The verified model is then expanded to higher pressures, beyond the limits of the experimental loop. Based on the numerical simulations, suggestions are given to extrapolate experimental data to higher (industrially important) pressure ranges. Using the numerical model and analytical estimation, the pump performance for the Pb-Li loop is also examined, and the ability of the designed pump to develop pressure heads over 6 bar and to provide flow rates over 15 kg/s is shown.

  19. Development of a model counter-rotating type horizontal-axis tidal turbine

    Science.gov (United States)

    Huang, B.; Yoshida, K.; Kanemoto, T.

    2016-05-01

    In the past decade, the tidal energies have caused worldwide concern as it can provide regular and predictable renewable energy resource for power generation. The majority of technologies for exploiting the tidal stream energy are based on the concept of the horizontal axis tidal turbine (HATT). A unique counter-rotating type HATT was proposed in the present work. The original blade profiles were designed according to the developed blade element momentum theory (BEMT). CFD simulations and experimental tests were adopted to the performance of the model counter-rotating type HATT. The experimental data provides an evidence of validation of the CFD model. Further optimization of the blade profiles was also carried out based on the CFD results.

  20. Aligning drivers, contract, and management of IT-outsourcing relationships: a type-dependent model

    DEFF Research Database (Denmark)

    Arenfeldt, Katrine; Corty Dam, Amalie; Fenger, Kim Harder

    2017-01-01

    In today’s competitive business environment, information technology outsourcing has become a wide-spread reality across all industries and sectors. Researchers have investigated this complex phenomenon from various angles, and established a sound knowledge base regarding the drivers, management......, and success factors related to IT outsourcing. However, little is known about the relationship between outsourcing drivers and goals on the one hand, and contractual and managerial aspects on the other hand. To overcome this gap, this study presents a synthesized conceptual model of existing literature...... that relates aspects of contractual governance and relationship management to three generic types of IT outsourcing, based on their underlying drivers: task-based, process-based, and partnership-based outsourcing. Our model identifies the specific contractual and managerial factors relevant for each type...

  1. BGK-type models in strong reaction and kinetic chemical equilibrium regimes

    International Nuclear Information System (INIS)

    Monaco, R; Bianchi, M Pandolfi; Soares, A J

    2005-01-01

    A BGK-type procedure is applied to multi-component gases undergoing chemical reactions of bimolecular type. The relaxation process towards local Maxwellians, depending on mass and numerical densities of each species as well as common velocity and temperature, is investigated in two different cases with respect to chemical regimes. These cases are related to the strong reaction regime characterized by slow reactions, and to the kinetic chemical equilibrium regime where fast reactions take place. The consistency properties of both models are stated in detail. The trend to equilibrium is numerically tested and comparisons for the two regimes are performed within the hydrogen-air and carbon-oxygen reaction mechanism. In the spatial homogeneous case, it is also shown that the thermodynamical equilibrium of the models recovers satisfactorily the asymptotic equilibrium solutions to the reactive Euler equations

  2. Intification and modelling of flight characteristics for self-build shock flyer type UAV

    Science.gov (United States)

    Rashid., Z. A.; Dardin, A. S. F. Syed.; Azid, A. A.; Ahmad, K. A.

    2018-02-01

    The development of an autonomous Unmanned Aerial Vehicle (UAV) requires a fundamentals studies of the UAV's flight characteristic. The aim of this study is to identify and model the flight characteristic of a conventional fixed-wing type UAV. Subsequence to this, the mode of flight of the UAV can be investigated. One technique to identify the characteristic of a UAV is a flight test where it required specific maneuvering to be executed while measuring the attitude sensor. In this study, a simple shock flyer type UAV was used as the aircraft. The result shows that the modeled flight characteristic has a significant relation with actual values but the fitting value is rather small. It is suggested that the future study is conducted with an improvement of the physical UAV, data filtering and better system identification methods.

  3. Molecular model of a type III secretion system needle: Implications for host-cell sensing.

    Science.gov (United States)

    Deane, Janet E; Roversi, Pietro; Cordes, Frank S; Johnson, Steven; Kenjale, Roma; Daniell, Sarah; Booy, Frank; Picking, William D; Picking, Wendy L; Blocker, Ariel J; Lea, Susan M

    2006-08-15

    Type III secretion systems are essential virulence determinants for many Gram-negative bacterial pathogens. The type III secretion system consists of cytoplasmic, transmembrane, and extracellular domains. The extracellular domain is a hollow needle protruding above the bacterial surface and is held within a basal body that traverses both bacterial membranes. Effector proteins are translocated, via this external needle, directly into host cells, where they subvert normal cell functions to aid infection. Physical contact with host cells initiates secretion and leads to formation of a pore, thought to be contiguous with the needle channel, in the host-cell membrane. Here, we report the crystal structure of the Shigella flexneri needle subunit MxiH and a complete model for the needle assembly built into our three-dimensional EM reconstruction. The model, combined with mutagenesis data, reveals that signaling of host-cell contact is relayed through the needle via intersubunit contacts and suggests a mode of binding for a tip complex.

  4. Time-Dependent Toroidal Compactification Proposals and the Bianchi Type I Model: Classical and Quantum Solutions

    Directory of Open Access Journals (Sweden)

    L. Toledo Sesma

    2016-01-01

    Full Text Available We construct an effective four-dimensional model by compactifying a ten-dimensional theory of gravity coupled with a real scalar dilaton field on a time-dependent torus. This approach is applied to anisotropic cosmological Bianchi type I model for which we study the classical coupling of the anisotropic scale factors with the two real scalar moduli produced by the compactification process. Under this approach, we present an isotropization mechanism for the Bianchi I cosmological model through the analysis of the ratio between the anisotropic parameters and the volume of the Universe which in general keeps constant or runs into zero for late times. We also find that the presence of extra dimensions in this model can accelerate the isotropization process depending on the momenta moduli values. Finally, we present some solutions to the corresponding Wheeler-DeWitt (WDW equation in the context of standard quantum cosmology.

  5. An Empirical Model for Vane-Type Vortex Generators in a Navier-Stokes Code

    Science.gov (United States)

    Dudek, Julianne C.

    2005-01-01

    An empirical model which simulates the effects of vane-type vortex generators in ducts was incorporated into the Wind-US Navier-Stokes computational fluid dynamics code. The model enables the effects of the vortex generators to be simulated without defining the details of the geometry within the grid, and makes it practical for researchers to evaluate multiple combinations of vortex generator arrangements. The model determines the strength of each vortex based on the generator geometry and the local flow conditions. Validation results are presented for flow in a straight pipe with a counter-rotating vortex generator arrangement, and the results are compared with experimental data and computational simulations using a gridded vane generator. Results are also presented for vortex generator arrays in two S-duct diffusers, along with accompanying experimental data. The effects of grid resolution and turbulence model are also examined.

  6. Modeling of a split type air conditioner with integrated water heater

    International Nuclear Information System (INIS)

    Techarungpaisan, P.; Theerakulpisut, S.; Priprem, S.

    2007-01-01

    This paper presents a steady state simulation model to predict the performance of a small split type air conditioner with integrated water heater. The mathematical model consists of submodels of system components such as evaporator, condenser, compressor, capillary tube, receiver and water heater. These submodels were built based on fundamental principles of heat transfer, thermodynamics, fluid mechanics, empirical relationships and manufacturer's data as necessary. The model was coded into a simulation program and used to predict system parameters of interest such as hot water temperature, condenser exit air temperature, evaporator exit air temperature, mass flow rate of refrigerant, heat rejection in the condenser and cooling capacity of the system. The simulation results were compared with experimental data obtained from an experimental rig built for validating the mathematical model. It was found that the experimental and simulation results are in good agreement

  7. A Brief Review on the Baer-Nunziato type Multi-pressure Multi-fluid Models

    International Nuclear Information System (INIS)

    Lee, Sang Yong; Park, Chan Eok; Lee, Gyu Cheon

    2010-01-01

    Single pressure two-fluid flow equations have complex characteristics. This causes ill-posedness problem. Even though some authors show that the numerical solutions are well behaved if the number of mesh points is sufficiently small, the stability of the solution is always challenged. There have been several attempts to overcome these problems. Multi-pressure multi-fluid models are one of them. Among them, Baer and Nunziato (BN) derived an interesting two-fluid model. BN model has independent phase pressures. It is closed by inserting volume fraction evolution equation. In this paper, several aspects of the BN type model will be reviewed and some suggestion for the future study will be made

  8. More supersymmetric standardlike models from intersecting D6-branes on type IIA orientifolds

    International Nuclear Information System (INIS)

    Cvetic, Mirjam; Papadimitriou, Ioannis

    2003-01-01

    We present new classes of supersymmetric standardlike models from a type IIA T 6 /(Z 2 xZ 2 ) orientifold with intersecting D6-branes. D6-branes can wrap general supersymmetric three-cycles of T 6 =T 2 xT 2 xT 2 , and any T 2 is allowed to be tilted. The models still suffer from additional exotics; however, we obtain solutions with fewer Higgs doublets, as well as models with all three families of left-handed quarks and leptons arising from the same intersecting sector, and examples of a genuine left-right symmetric model with three copies of left-handed and right-handed families of quarks and leptons

  9. Fatores associados à soropositividade do teste ML Flow em pacientes e contatos de pacientes com hanseníase menores de 18 anos Factors associated with ML Flow test seropositivity in leprosy patients and household contacts under the age of 18

    Directory of Open Access Journals (Sweden)

    Maria Aparecida Alves Ferreira

    2008-01-01

    Full Text Available Estudo transversal em menores de 18 anos, sendo 115 casos novos de hanseníase e 1.011 contatos intradomiciliares. Determinaram-se as proporções da soropositividade do ML Flow e fatores associados ao teste positivo. Observou-se soropositividade em 21,7% dos pacientes e 19,7% dos contatos. Nos pacientes, a regressão logística indicou associação com baciloscopia positiva e número de lesões cutâneas maior que cinco. A análise por árvore de decisão mostrou associação com baciloscopia, classificação de Madri, número de nervos acometidos e idade. Nos contatos, as duas análises indicaram as mesmas associações: classificação do caso-índice, idade e tipo de serviço de saúde. As variáveis que explicaram melhor a soropositividade, em menores de 18 anos, são aquelas associadas à maior carga bacilar. Assim, o teste ML Flow poderia ser utilizado também na infância para ajudar na correta classificação dos pacientes para tratamento e na identificação dos contatos com maior risco de desenvolver hanseníase.This article presents the results of a cross-sectional study involving 115 newly-diagnosed leprosy patients and 1,011 household contacts, all under the age of 18. Seropositivity ratios and factors associated with a positive ML Flow were determined. The test was positive in 21.7% of patients and in 19.7% of contacts. Among patients, logistic regression indicated the association of seropositivity with positive slit skin smear and having more than five skin lesions. The tree method analysis indicated associations with skin smear, Madrid classification, number of nerves affected and age. In the contact group, index case classification, age and type of health service were associated with seropositivity in both analyses. The variables that best explained seropositivity are those associated with higher bacterial load. Therefore, the ML Flow test could be used in children to aid correct classification of patients for treatment and to

  10. Bianchi type-VIh string cloud cosmological models with bulk viscosity

    Science.gov (United States)

    Tripathy, Sunil K.; Behera, Dipanjali

    2010-11-01

    String cloud cosmological models are studied using spatially homogeneous and anisotropic Bianchi type VIh metric in the frame work of general relativity. The field equations are solved for massive string cloud in presence of bulk viscosity. A general linear equation of state of the cosmic string tension density with the proper energy density of the universe is considered. The physical and kinematical properties of the models have been discussed in detail and the limits of the anisotropic parameter responsible for different phases of the universe are explored.

  11. Torsional fatigue model for limitorque type SMB/SB/SBD actuators for motor-operated valves

    Energy Technology Data Exchange (ETDEWEB)

    Somogyi, D.; Alvarez, P.D.; Kalsi, M.S. [Kalsi Engineering, Inc., Sugar Land, TX (United States)

    1996-12-01

    Kalsi Engineering, Inc. has recently developed a computer program to predict the torsional fatigue life of Limitorque Type SMB/SB/SBD actuators for motor-operated valves under given loading levels, including those that exceed the ratings. The development effort was an outgrowth of the {open_quote}Thrust Rating Increase{close_quote} test program. The fatigue model computes all pertinent stress components and their variations as a function of the loading ramp. The cumulative damage and fatigue life due to stress cycling is computed by use of a modification of Miner`s rule. Model predictions were validated against actual cyclic loading test results.

  12. Torsional fatigue model for limitorque type SMB/SB/SBD actuators for motor-operated valves

    International Nuclear Information System (INIS)

    Somogyi, D.; Alvarez, P.D.; Kalsi, M.S.

    1996-01-01

    Kalsi Engineering, Inc. has recently developed a computer program to predict the torsional fatigue life of Limitorque Type SMB/SB/SBD actuators for motor-operated valves under given loading levels, including those that exceed the ratings. The development effort was an outgrowth of the open-quote Thrust Rating Increase close-quote test program. The fatigue model computes all pertinent stress components and their variations as a function of the loading ramp. The cumulative damage and fatigue life due to stress cycling is computed by use of a modification of Miner's rule. Model predictions were validated against actual cyclic loading test results

  13. Dynamic Analysis of an Impulsively Controlled Predator-Prey Model with Holling Type IV Functional Response

    Directory of Open Access Journals (Sweden)

    Yanzhen Wang

    2012-01-01

    Full Text Available The dynamic behavior of a predator-prey model with Holling type IV functional response is investigated with respect to impulsive control strategies. The model is analyzed to obtain the conditions under which the system is locally asymptotically stable and permanent. Existence of a positive periodic solution of the system and the boundedness of the system is also confirmed. Furthermore, numerical analysis is used to discover the influence of impulsive perturbations. The system is found to exhibit rich dynamics such as symmetry-breaking pitchfork bifurcation, chaos, and nonunique dynamics.

  14. Radius stabilization and brane running in the Randall-Sundrum type 1 model

    International Nuclear Information System (INIS)

    Brevik, Iver; Ghoroku, Kazuo; Yahiro, Masanobu

    2004-01-01

    We study the effective potential of a scalar field based on the 5D gauged supergravity for the Randall-Sundrum type one brane model in terms of the brane running method. The scalar couples to the brane such that the Bogomolnyi-Prasad-Sommerfield conditions are satisfied for the bulk configuration. The resulting effective potential implies that the interbrane distance is undetermined in this case, and we need a small Bogomolnyi-Prasad-Sommerfield breaking term on the brane to stabilize the interbrane distance at a finite length. We also discuss the relationship to the Goldberger-Wise model

  15. A unified phenomenological model for non-elastic deformation of Type 316 stainless steel

    International Nuclear Information System (INIS)

    Schmidt, C.G.; Miller, A.K.

    1981-01-01

    A complete model is provided for the non-elastic deformation of unaged type 316 stainless steel. The fitting flexibility, breadth of application, and predictive capabilities of the model are demonstrated for a wide variety of data. Satisfactory descriptions are given of the steady-state and transient creep behaviour as well as the monotonic stress-strain behaviour from the yield stress to steady-state flow. These descriptions apply over a broad range of temperatures and strain rates for both solution annealed and 20% cold worked material. Furthermore, cyclic stress-strain curves, cyclic hysteresis loops, and stress relaxation data are shown to be well described for solution annealed material. (author)

  16. Modeling and Optimization of M/G/1-Type Queueing Networks: An Efficient Sensitivity Analysis Approach

    Directory of Open Access Journals (Sweden)

    Liang Tang

    2010-01-01

    Full Text Available A mathematical model for M/G/1-type queueing networks with multiple user applications and limited resources is established. The goal is to develop a dynamic distributed algorithm for this model, which supports all data traffic as efficiently as possible and makes optimally fair decisions about how to minimize the network performance cost. An online policy gradient optimization algorithm based on a single sample path is provided to avoid suffering from a “curse of dimensionality”. The asymptotic convergence properties of this algorithm are proved. Numerical examples provide valuable insights for bridging mathematical theory with engineering practice.

  17. Dynamics of a Lotka-Volterra type model with applications to marine phage population dynamics

    International Nuclear Information System (INIS)

    Gavin, C; Pokrovskii, A; Prentice, M; Sobolev, V

    2006-01-01

    The famous Lotka-Volterra equations play a fundamental role in the mathematical modeling of various ecological and chemical systems. A new modification of these equations has been recently suggested to model the structure of marine phage populations, which are the most abundant biological entities in the biosphere. The purpose of the paper is: (i) to make some methodical remarks concerning this modification; (ii) to discuss new types of canards which arise naturally in this context; (iii) to present results of some numerical experiments

  18. Video Modeling Training Effects on Types of Attention Delivered by Educational Care-Providers.

    Science.gov (United States)

    Taber, Traci A; Lambright, Nathan; Luiselli, James K

    2017-06-01

    We evaluated the effects of abbreviated (i.e., one-session) video modeling on delivery of student-preferred attention by educational care-providers. The video depicted a novel care-provider interacting with and delivering attention to the student. Within a concurrent multiple baseline design, video modeling increased delivery of the targeted attention for all participants as well as their delivery of another type of attention that was not trained although these effects were variable within and between care-providers. We discuss the clinical and training implications from these findings.

  19. Craniofacial Statistical Deformation Models of Wild-type mice and Crouzon mice

    DEFF Research Database (Denmark)

    Ólafsdóttir, Hildur; Darvann, Tron Andre; Ersbøll, Bjarne Kjær

    2007-01-01

    Crouzon syndrome is characterised by the premature fusion of cranial sutures and synchondroses leading to craniofacial growth disturbances. The gene causing the syndrome was discovered approximately a decade ago and recently the first mouse model of the syndrome was generated. In this study, a set...... of Micro CT scannings of the heads of wild-type (normal) mice and Crouzon mice were investigated. Statistical deformation models were built to assess the anatomical differences between the groups, as well as the within-group anatomical variation. Following the approach by Rueckert et al. we built an atlas...

  20. Algebraic Traveling Wave Solutions of a Non-local Hydrodynamic-type Model

    International Nuclear Information System (INIS)

    Chen, Aiyong; Zhu, Wenjing; Qiao, Zhijun; Huang, Wentao

    2014-01-01

    In this paper we consider the algebraic traveling wave solutions of a non-local hydrodynamic-type model. It is shown that algebraic traveling wave solutions exist if and only if an associated first order ordinary differential system has invariant algebraic curve. The dynamical behavior of the associated ordinary differential system is analyzed. Phase portraits of the associated ordinary differential system is provided under various parameter conditions. Moreover, we classify algebraic traveling wave solutions of the model. Some explicit formulas of smooth solitary wave and cuspon solutions are obtained

  1. Modelling the WWER-type reactor dynamics using a hybrid computer. Part 1

    International Nuclear Information System (INIS)

    Karpeta, C.

    Results of simulation studies into reactor and steam generator dynamics of a WWER type power plant are presented. Spatial kinetics of the reactor core is described by a nodal approximation to diffusion equations, xenon poisoning equations and heat transfer equations. The simulation of the reactor model dynamics was performed on a hybrid computer. Models of both a horizontal and a vertical steam generator were developed. The dynamics was investigated over a large range of power by computing the transients on a digital computer. (author)

  2. A non-local hidden-variable model that violates Leggett-type inequalities

    Energy Technology Data Exchange (ETDEWEB)

    Zela, F de [Departamento de Ciencias, Seccion Fisica, Pontificia Universidad Catolica del Peru, Apartado 1761, Lima (Peru)

    2008-12-19

    Recent experiments of Groeblacher et al proved the violation of a Leggett-type inequality that was claimed to be valid for a broad class of non-local hidden-variable theories. The impossibility of constructing a non-local and realistic theory, unless it entails highly counterintuitive features, seems thus to have been experimentally proved. This would bring us close to a definite refutation of realism. Indeed, realism was proved to be also incompatible with locality, according to a series of experiments testing Bell inequalities. The present paper addresses the said experiments of Groeblacher et al and presents an explicit, contextual and realistic, model that reproduces the predictions of quantum mechanics. It thus violates the Leggett-type inequality that was established with the aim of ruling out a supposedly broad class of non-local models. We can thus conclude that plausible contextual, realistic, models are still tenable. This restates the possibility of a future completion of quantum mechanics by a realistic and contextual theory which is not in a class containing only highly counterintuitive models. The class that was ruled out by the experiments of Groeblacher et al is thus proved to be a limited one, arbitrarily separating models that physically belong in the same class.

  3. A consensus model for group decision making under interval type-2 fuzzy environment

    Institute of Scientific and Technical Information of China (English)

    Xiao-xiong ZHANG; Bing-feng GE; Yue-jin TAN

    2016-01-01

    We propose a new consensus model for group decision making (GDM) problems, using an interval type-2 fuzzy environment. In our model, experts are asked to express their preferences using linguistic terms characterized by interval type-2 fuzzy sets (IT2 FSs), because these can provide decision makers with greater freedom to express the vagueness in real-life situa-tions. Consensus and proximity measures based on the arithmetic operations of IT2 FSs are used simultaneously to guide the decision-making process. The majority of previous studies have taken into account only the importance of the experts in the aggregation process, which may give unreasonable results. Thus, we propose a new feedback mechanism that generates different advice strategies for experts according to their levels of importance. In general, experts with a lower level of importance require a larger number of suggestions to change their initial preferences. Finally, we investigate a numerical example and execute com-parable models and ours, to demonstrate the performance of our proposed model. The results indicate that the proposed model provides greater insight into the GDM process.

  4. A MODEL FOR TYPE 2 CORONAL LINE FOREST (CLiF) AGNs

    Energy Technology Data Exchange (ETDEWEB)

    Glidden, Ana [Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (United States); Rose, Marvin; Elvis, Martin; McDowell, Jonathan [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States)

    2016-06-10

    We present a model for the classification of Coronal Line Forest Active Galactic Nuclei (CLiF AGNs). CLiF AGNs are of special interest due to their remarkably large number of emission lines, especially forbidden high-ionization lines (FHILs). Rose et al. suggest that their emission is dominated by reflection from the inner wall of the obscuring region rather than direct emission from the accretion disk. This makes CLiF AGNs laboratories to test AGN-torus models. Modeling an AGN as an accreting supermassive black hole surrounded by a cylinder of dust and gas, we show a relationship between the viewing angle and the revealed area of the inner wall. From the revealed area, we can determine the amount of FHIL emission at various angles. We calculate the strength of [Fe vii] λ 6087 emission for a number of intermediate angles (30°, 40°, and 50°) and compare the results with the luminosity of the observed emission line from six known CLiF AGNs. We find that there is good agreement between our model and the observational results. The model also enables us to determine the relationship between the type 2:type 1 AGN fraction vs the ratio of torus height to radius, h / r .

  5. A non-local hidden-variable model that violates Leggett-type inequalities

    International Nuclear Information System (INIS)

    Zela, F de

    2008-01-01

    Recent experiments of Groeblacher et al proved the violation of a Leggett-type inequality that was claimed to be valid for a broad class of non-local hidden-variable theories. The impossibility of constructing a non-local and realistic theory, unless it entails highly counterintuitive features, seems thus to have been experimentally proved. This would bring us close to a definite refutation of realism. Indeed, realism was proved to be also incompatible with locality, according to a series of experiments testing Bell inequalities. The present paper addresses the said experiments of Groeblacher et al and presents an explicit, contextual and realistic, model that reproduces the predictions of quantum mechanics. It thus violates the Leggett-type inequality that was established with the aim of ruling out a supposedly broad class of non-local models. We can thus conclude that plausible contextual, realistic, models are still tenable. This restates the possibility of a future completion of quantum mechanics by a realistic and contextual theory which is not in a class containing only highly counterintuitive models. The class that was ruled out by the experiments of Groeblacher et al is thus proved to be a limited one, arbitrarily separating models that physically belong in the same class

  6. On the asymptotic behavior of a boltzmann-type price formation model

    KAUST Repository

    Burger, Martin; Caffarelli, Luis A.; Markowich, Peter A.; Wolfram, Marie-Therese

    2014-01-01

    In this paper we study the asymptotic behavior of a Boltzmann-type price formation model, which describes the trading dynamics in a financial market. In many of these markets trading happens at high frequencies and low transaction costs. This observation motivates the study of the limit as the number of transactions k tends to infinity, the transaction cost a to zero and ka=const. Furthermore we illustrate the price dynamics with numerical simulations © 2014 International Press.

  7. Flow and mixing of liquid steel in multi-strand tundish delta type – physical modelling

    Directory of Open Access Journals (Sweden)

    T. Merder

    2015-01-01

    Full Text Available The article presents the results of liquid steel flow and mixing in tundish when applying different equipment to modernize the tundish working zone. The six-strand continuous casting tundish of a trough-type was studied. Such tundish is an object with geometry adjusted to the conditions of particular CC machine, which is installed in one of a polish steel plant. The problems suggested in research were solved basing on physical model experiment.

  8. Locally Rotationally Symmetric Bianchi Type-I Model with Time Varying Λ Term

    International Nuclear Information System (INIS)

    Tiwari, R. K.; Jha, Navin Kumar

    2009-01-01

    We investigate the locally rotationally symmetric (LRS) Bianchi type-I cosmological model for stiff matter and a vacuum solution with a cosmological term proportional to R −m (R is the scale factor and m is a positive constant). The cosmological term decreases with time. We obtain that for both the cases the present universe is accelerating with a large fraction of cosmological density in the form of a cosmological term

  9. Adler-type sum rule, charge symmetry and neutral current in general multi-triplet model

    International Nuclear Information System (INIS)

    Katuya, Mituaki; Baba, Yoshimitsu; Fujii, Kanji

    1975-01-01

    We derive Adler-type sum rule extended to general multi-triplet model. Paying attention to roles of the colour degree of freedom, we discuss the charge symmetry property of the weak charged current and the structure functions for ν(ν - )+N→l(l - )+X, and also the structure of the neutral current. A comment is given on implications in our theory of Koike and Konuma's result on the neutral hadronic current. (auth.)

  10. Model of nuclear reactor type VVER-1000/V-320 built by computer code ATHLET-CD

    International Nuclear Information System (INIS)

    Georgiev, Yoto; Filipov, Kalin; Velev, Vladimir

    2014-01-01

    A model of nuclear reactor type VVER-1000 V-320 developed for computer code ATHLET-CD2.1A is presented. Validation of the has been made, in the analysis of the station blackout scenario with LOCA on fourth cold leg is shown. As the calculation has been completed, the results are checked through comparison with the results from the computer codes ATHLET-2.1A, ASTEC-2.1 and RELAP5mod3.2

  11. Estimation of stochastic volatility by using Ornstein-Uhlenbeck type models

    Science.gov (United States)

    Mariani, Maria C.; Bhuiyan, Md Al Masum; Tweneboah, Osei K.

    2018-02-01

    In this study, we develop a technique for estimating the stochastic volatility (SV) of a financial time series by using Ornstein-Uhlenbeck type models. Using the daily closing prices from developed and emergent stock markets, we conclude that the incorporation of stochastic volatility into the time varying parameter estimation significantly improves the forecasting performance via Maximum Likelihood Estimation. Furthermore, our estimation algorithm is feasible with large data sets and have good convergence properties.

  12. Dynamics of a three species food chain model with Crowley-Martin type functional response

    International Nuclear Information System (INIS)

    Upadhyay, Ranjit Kumar; Naji, Raid Kamel

    2009-01-01

    In this paper, a three species food chain model, consisting of a hybrid type of prey-dependent and predator-dependent functional responses, is investigated analytically as well as numerically. The local and global stability analysis is carried out. The persistence conditions are established. Bifurcation diagrams are obtained for biologically feasible parameters. The results show that the system exhibits rich complexity features such as stable, periodic and chaotic dynamics.

  13. THEORETICAL AND EXPERIMENTAL CONTRIBUTIONS CONCERNING THE PROPOSED MODEL FOR THE DISC-TYPED ROTARY ULTRASONIC MOTOR

    Directory of Open Access Journals (Sweden)

    Oana CHIVU

    2010-10-01

    Full Text Available In this work the proposed model for type-disk, ultrasonic motor rotating, elliptic movement to surface beam. A sinusoidal vibration of the vertical displacement in the z-direction, Assume that the vertical displacement of the neutral plane, equals the product of the slope of the neutral plane and half of the beam height, the tangential velocity vs at the upper surface is given.

  14. Inelastic response of PCRV structure model with star-type support under horizontal loads

    International Nuclear Information System (INIS)

    Suzuki, T.; Yamaguchi, T.; Takeda, T.

    1978-01-01

    The report presents the test results of scaled models for prestressed concrete reactor vessel (PCRV) structure with star-shaped support under horizontal loads. A scale factor of 1 / 70 to a proto-type PCRV structure for large HTGR is used for both static and dynamic loading test models, while a 1 / 15 scaled model is used for static loading tests. The static behaviors such as a load-deflection envelope of the 1 / 70 model are predicted well by an inelastic analysis in consideration with appearance of concrete cracks and reinforcing bar yielding. It is also ascertained by the test results of the 1 / 15 model under static alternative loads that the same analysis procedure can be applicable to the evaluation of the elastic and inelastic behaviors of PCRV structure with support. Based on the static loading test results of both scaled models, a tri-linearized load-deflection envelope and an equivalent linearized mathematical model for hysteresis loop are assumed in a dynamic analysis. A dynamic response analysis of the 1 / 70 model subjected to earthquake-like base motion is conducted by the similar manner above-mentioned and the calculated results show a good correlation with the test results

  15. A lumped parameter core dynamics model for MTR type research reactors under natural convection regime

    International Nuclear Information System (INIS)

    Ardaneh, Kazem; Zaferanlouei, Salman

    2013-01-01

    Highlights: ► A model is presented to simulate the reactivity insertion transient in MTR reactors. ► Transient dynamics of IAEA 10 MW MTR type research reactor are evaluated. ► Maximum unprotected reactivity insertion for safe condition is calculated. ► The model predictions are validated with corresponding results in the literature. - Abstract: On the basis of lumped parameter modeling of both the kinetic and thermal–hydraulic effects, a reasonably accurate simplified model has been developed to predict the dynamic response of MTR reactors following to an unprotected reactivity insertion under natural convection regime. By this model the reactor transient behavior at a given initial steady-state can be solved by a set of ordinary differential equations. The model predictions have an acceptable consent with corresponding results of reactivity insertion transients analyzed in the literature. The inherent safety characteristics of MTR research reactors utilizing natural convection is clearly demonstrated by the expanded model. The safety margin of reactor operating is selected ONB condition and thereby the proposed model determines that any slight increase in the value of $0.73 for inserted reactivity will cause the maximum cladding surface temperature to exceed the ONB condition

  16. Alteration of 'R7T7' type nuclear glasses: statistical approach, experimental validation, local evolution model

    International Nuclear Information System (INIS)

    Thierry, F.

    2003-02-01

    The aim of this work is to propose an evolution of nuclear (R7T7-type) glass alteration modeling. The first part of this thesis is about development and validation of the 'r(t)' model. This model which predicts the decrease of alteration rates in confined conditions is based upon a coupling between a first-order dissolution law and a diffusion barrier effect of the alteration gel layer. The values and the uncertainties regarding the main adjustable parameters of the model (α, Dg and C*) have been determined from a systematic study of the available experimental data. A program called INVERSION has been written for this purpose. This work lead to characterize the validity domain of the 'r(t)' model and to parametrize it. Validation experiments have been undertaken, confirming the validity of the parametrization over 200 days. A new model is proposed in the second part of this thesis. It is based on an inhibition of glass dissolution reaction by silicon coupled with a local description of silicon retention in the alteration gel layer. This model predicts the evolutions of boron and silicon concentrations in solution as well as the concentrations and retention profiles in the gel layer. These predictions have been compared to measurements of retention profiles by the secondary ion mass spectrometry (SIMS) method. The model has been validated on fractions of gel layer which reactivity present low or moderate disparities. (author)

  17. Experiment and analysis of CASTOR type model cask for verification of radiation shielding

    Energy Technology Data Exchange (ETDEWEB)

    Hattori, Seiichi; Ueki, Kohtaro.

    1988-08-01

    The radiation shielding system of CASTOR type cask is composed of the graphite cast iron and the polyethylene lod. The former fomes the cylndrical body of the cask to shield gamma rays and the latter is embeded in the body to shield neutrons. Characteristic of radiation shielding of CASTOR type cask is that zigzag arrangement of the polyethylene lod is adopted to unify the penetrating dose rate. It is necessary to use the three-dimensional analysis code to analyse the shielding performance of the cask with the complicated shielding system precisely. However, it takes too much time as well as too much cost. Therefore, the two-dimensional analysis is usually applied, in which the three-dimensional model is equivalently transformed into the two-dimensional calculation. The reseach study was conducted to verify the application of the two-dimensional analysis, in which the experiment and the analysis using CASTOR type model cask was perfomed. The model cask was manufactured by GNS campany in West Germany and the shielding ability test facilities in CRIEPI were used. It was judged from the study that the two-dimensional analysis is useful means for the practical use.

  18. Diversity and plasticity of Th cell types predicted from regulatory network modelling.

    Directory of Open Access Journals (Sweden)

    Aurélien Naldi

    Full Text Available Alternative cell differentiation pathways are believed to arise from the concerted action of signalling pathways and transcriptional regulatory networks. However, the prediction of mammalian cell differentiation from the knowledge of the presence of specific signals and transcriptional factors is still a daunting challenge. In this respect, the vertebrate hematopoietic system, with its many branching differentiation pathways and cell types, is a compelling case study. In this paper, we propose an integrated, comprehensive model of the regulatory network and signalling pathways controlling Th cell differentiation. As most available data are qualitative, we rely on a logical formalism to perform extensive dynamical analyses. To cope with the size and complexity of the resulting network, we use an original model reduction approach together with a stable state identification algorithm. To assess the effects of heterogeneous environments on Th cell differentiation, we have performed a systematic series of simulations considering various prototypic environments. Consequently, we have identified stable states corresponding to canonical Th1, Th2, Th17 and Treg subtypes, but these were found to coexist with other transient hybrid cell types that co-express combinations of Th1, Th2, Treg and Th17 markers in an environment-dependent fashion. In the process, our logical analysis highlights the nature of these cell types and their relationships with canonical Th subtypes. Finally, our logical model can be used to explore novel differentiation pathways in silico.

  19. The exactly solvable spin Sutherland model of BN type and its related spin chain

    International Nuclear Information System (INIS)

    Basu-Mallick, B.; Finkel, F.; González-López, A.

    2013-01-01

    We compute the spectrum of the su(m) spin Sutherland model of B N type, including the exact degeneracy of all energy levels. By studying the large coupling constant limit of this model and of its scalar counterpart, we evaluate the partition function of their associated spin chain of Haldane–Shastry type in closed form. With the help of the formula for the partition function thus obtained we study the chain's spectrum, showing that it cannot be obtained as a limiting case of its BC N counterpart. The structure of the partition function also suggests that the spectrum of the Haldane–Shastry spin chain of B N type is equivalent to that of a suitable vertex model, as is the case for its A N−1 counterpart, and that the density of its eigenvalues is normally distributed when the number of sites N tends to infinity. We analyze this last conjecture numerically using again the explicit formula for the partition function, and check its validity for several values of N and m.

  20. Tests of Parameters Instability: Theoretical Study and Empirical Applications on Two Types of Models (ARMA Model and Market Model

    Directory of Open Access Journals (Sweden)

    Sahbi FARHANI

    2012-01-01

    Full Text Available This paper considers tests of parameters instability and structural change with known, unknown or multiple breakpoints. The results apply to a wide class of parametric models that are suitable for estimation by strong rules for detecting the number of breaks in a time series. For that, we use Chow, CUSUM, CUSUM of squares, Wald, likelihood ratio and Lagrange multiplier tests. Each test implicitly uses an estimate of a change point. We conclude with an empirical analysis on two different models (ARMA model and simple linear regression model.

  1. The Relevance of Using Mathematical Models in Macroeconomic Policies Theory

    Directory of Open Access Journals (Sweden)

    Nora Mihail

    2006-11-01

    Full Text Available The article presents a look of the principal’s mathematical models – starting with Theil, Hansen and Tinbergen work – and their results used to analysis and design macroeconomic policies. In modeling field changes are very fast in theoretical aspects of modeling the many problems of macroeconomic policies and in using in practice the different political models elaboration. The article points out the problems of static and dynamic theory used in macro-policies modeling.

  2. The Relevance of Using Mathematical Models in Macroeconomic Policies Theory

    Directory of Open Access Journals (Sweden)

    Nora Mihail

    2006-09-01

    Full Text Available The article presents a look of the principal’s mathematical models – starting with Theil, Hansen and Tinbergen work – and their results used to analysis and design macroeconomic policies. In modeling field changes are very fast in theoretical aspects of modeling the many problems of macroeconomic policies and in using in practice the different political models elaboration. The article points out the problems of static and dynamic theory used in macro-policies modeling.

  3. Evaluation and Monitoring of Mycobacterium leprae Transmission in Household Contacts of Patients with Hansen's Disease in Colombia.

    Science.gov (United States)

    Romero-Montoya, Marcela; Beltran-Alzate, Juan Camilo; Cardona-Castro, Nora

    2017-01-01

    Leprosy in Colombia is in a stage of post elimination-since 1997, prevalence of the disease is less than 1/10000. However, the incidence of leprosy has remained stable, with 400-500 new cases reported annually, with MB leprosy representing 70% of these case and 10% having grade 2 disability. Thus, leprosy transmission is still occurring, and household contacts (HHCs) of leprosy patients are a population at high risk of contracting and suffering from the effects of the disease during their lifetime. We performed a cross-sectional study with the aim of evaluating leprosy transmission within Family Groups (FGs) from four Colombian departments: Antioquia, Bolívar, Córdoba and Sucre. This study included 159 FGs formed by 543 HHCs; 45 FGs were monitored twice, first in 2003 and again in 2012. Migration, forced displacement by violence, loss of contact with the health center and the lack of an agreement to participate in the second monitoring were the primary reasons not all FGs were tested a second time. In each HHC, a clinical examination was performed, epidemiological data recorded, the bacillary index determined, DNA was isolated for M. leprae detection by nested PCR and IgM anti-phenolic glycolipid-I (PGL-I) titers were inspected. Further, DNA from M. leprae isolates were typed and compared among FGs. Twenty-two (4.1%) of the 543 HHCs had IgM anti-PGL-I positive antibody titers, indicating infection. Nasal swabs (NS) taken from 113 HHCs were tested by RLEP PCR; 18 (16%) were positive for M. leprae DNA and two new leprosy cases were detected among the HHCs. Of the confirmed HHCs with leprosy, it was possible to genotype the bacterial strains from both the index case and their HHCs. We found that the genotype of these two strains agreed at 9 markers, showing the individuals to be infected by the same strain, indicating familiar transmission. HHCs of leprosy patients not only are a high-risk population for M. leprae infection, they can act as M. leprae carriers and

  4. Monte Carlo Simulation Of The Portfolio-Balance Model Of Exchange Rates: Finite Sample Properties Of The GMM Estimator

    OpenAIRE

    Hong-Ghi Min

    2011-01-01

    Using Monte Carlo simulation of the Portfolio-balance model of the exchange rates, we report finite sample properties of the GMM estimator for testing over-identifying restrictions in the simultaneous equations model. F-form of Sargans statistic performs better than its chi-squared form while Hansens GMM statistic has the smallest bias.

  5. Related Progenitor Models for Long-duration Gamma-Ray Bursts and Type Ic Superluminous Supernovae

    Science.gov (United States)

    Aguilera-Dena, David R.; Langer, Norbert; Moriya, Takashi J.; Schootemeijer, Abel

    2018-05-01

    We model the late evolution and mass loss history of rapidly rotating Wolf–Rayet stars in the mass range 5 M ⊙…100 M ⊙). We find that quasi-chemically homogeneously evolving single stars computed with enhanced mixing retain very little or no helium and are compatible with Type Ic supernovae. The more efficient removal of core angular momentum and the expected smaller compact object mass in our lower-mass models lead to core spins in the range suggested for magnetar-driven superluminous supernovae. Our higher-mass models retain larger specific core angular momenta, expected for long-duration gamma-ray bursts in the collapsar scenario. Due to the absence of a significant He envelope, the rapidly increasing neutrino emission after core helium exhaustion leads to an accelerated contraction of the whole star, inducing a strong spin-up and centrifugally driven mass loss at rates of up to {10}-2 {M}ȯ {yr}}-1 in the last years to decades before core collapse. Because the angular momentum transport in our lower-mass models enhances the envelope spin-up, they show the largest relative amounts of centrifugally enforced mass loss, i.e., up to 25% of the expected ejecta mass. Our most massive models evolve into the pulsational pair-instability regime. We would thus expect signatures of interaction with a C/O-rich circumstellar medium for Type Ic superluminous supernovae with ejecta masses below ∼10 M ⊙ as well as for the most massive engine-driven explosions with ejecta masses above ∼30 M ⊙. Signs of such interaction should be observable at early epochs of the supernova explosion; they may be related to bumps observed in the light curves of superluminous supernovae, or to the massive circumstellar CO-shell proposed for Type Ic superluminous supernova Gaia16apd.

  6. Hierarchical Models for Type Ia Supernova Light Curves in the Optical and Near Infrared

    Science.gov (United States)

    Mandel, Kaisey; Narayan, G.; Kirshner, R. P.

    2011-01-01

    I have constructed a comprehensive statistical model for Type Ia supernova optical and near infrared light curves. Since the near infrared light curves are excellent standard candles and are less sensitive to dust extinction and reddening, the combination of near infrared and optical data better constrains the host galaxy extinction and improves the precision of distance predictions to SN Ia. A hierarchical probabilistic model coherently accounts for multiple random and uncertain effects, including photometric error, intrinsic supernova light curve variations and correlations across phase and wavelength, dust extinction and reddening, peculiar velocity dispersion and distances. An improved BayeSN MCMC code is implemented for computing probabilistic inferences for individual supernovae and the SN Ia and host galaxy dust populations. I use this hierarchical model to analyze nearby Type Ia supernovae with optical and near infared data from the PAIRITEL, CfA3, and CSP samples and the literature. Using cross-validation to test the robustness of the model predictions, I find that the rms Hubble diagram scatter of predicted distance moduli is 0.11 mag for SN with optical and near infrared data versus 0.15 mag for SN with only optical data. Accounting for the dispersion expected from random peculiar velocities, the rms intrinsic prediction error is 0.08-0.10 mag for SN with both optical and near infrared light curves. I discuss results for the inferred intrinsic correlation structures of the optical-NIR SN Ia light curves and the host galaxy dust distribution captured by the hierarchical model. The continued observation and analysis of Type Ia SN in the optical and near infrared is important for improving their utility as precise and accurate cosmological distance indicators.

  7. Personality, personal model beliefs, and self-care in adolescents and young adults with Type 1 diabetes

    DEFF Research Database (Denmark)

    Chas Skinner, T.; Hampson, Sarah E.; Fife-Schaw, Chris

    2002-01-01

    This study compared 3 models of association between personality, personal model beliefs, and self-care in a cross-sectional design. These models were as follows: (a) Emotional stability determines self-care indirectly through personal model beliefs, and conscientiousness is a direct predictor of ....... Participants (N = 358, aged 12-30 years) with Type 1 diabetes completed measures of personality, personal model beliefs, and self-care. Structural equation modeling indicated that Model C was the best fit to the data....

  8. Continuous-time interval model identification of blood glucose dynamics for type 1 diabetes

    Science.gov (United States)

    Kirchsteiger, Harald; Johansson, Rolf; Renard, Eric; del Re, Luigi

    2014-07-01

    While good physiological models of the glucose metabolism in type 1 diabetic patients are well known, their parameterisation is difficult. The high intra-patient variability observed is a further major obstacle. This holds for data-based models too, so that no good patient-specific models are available. Against this background, this paper proposes the use of interval models to cover the different metabolic conditions. The control-oriented models contain a carbohydrate and insulin sensitivity factor to be used for insulin bolus calculators directly. Available clinical measurements were sampled on an irregular schedule which prompts the use of continuous-time identification, also for the direct estimation of the clinically interpretable factors mentioned above. An identification method is derived and applied to real data from 28 diabetic patients. Model estimation was done on a clinical data-set, whereas validation results shown were done on an out-of-clinic, everyday life data-set. The results show that the interval model approach allows a much more regular estimation of the parameters and avoids physiologically incompatible parameter estimates.

  9. Model-based analysis of postprandial glycemic response dynamics for different types of food

    Directory of Open Access Journals (Sweden)

    Yvonne J. Rozendaal

    2018-06-01

    Full Text Available Summary: Background & aims: Knowledge of postprandial glycemic response (PPGR dynamics is important in nutrition management and diabetes research, care and (selfmanagement. In daily life, food intake is the most important factor influencing the occurrence of hyperglycemia. However, the large variability in PPGR dynamics to different types of food is inadequately predicted by existing glycemic measures. The objective of this study was therefore to quantitatively describe PPGR dynamics using a systems approach. Methods: Postprandial glucose and insulin data were collected from literature for many different food products and mixed meals. The predictive value of existing measures, such as the Glycemic Index, was evaluated. A physiology-based dynamic model was used to reconstruct the full postprandial response profiles of both glucose and insulin simultaneously. Results: We collected a large range of postprandial glucose and insulin dynamics for 53 common food products and mixed meals. Currently available glycemic measures were found to be inadequate to describe the heterogeneity in postprandial dynamics. By estimating model parameters from glucose and insulin data, the physiology-based dynamic model accurately describes the measured data whilst adhering to physiological constraints. Conclusions: The physiology-based dynamic model provides a systematic framework to analyze postprandial glucose and insulin profiles. By changing parameter values the model can be adjusted to simulate impaired glucose tolerance and insulin resistance. Keywords: Postprandial glycemic response, Physiology-based dynamic model, Food intake, Computational modeling, Glucose, Insulin

  10. Pedestal Temperature Model for Type III ELMy H-mode Plasma

    International Nuclear Information System (INIS)

    Buangam, W.; Suwanna, S.; Onjun, T.; Poolyarat, N.; Picha, R.; Singhsomroje, W.

    2009-07-01

    Full text: It is widely known that the improved performance of H-mode plasma results mainly from a formation of the pedestal, which is a narrow region of strong pressure gradient near the edge of plasma. A predictive capability for the conditions at the top of the pedestal is important, especially for predictive simulations of future experiments. New models for predicting the temperature values at the top of the pedestal for type III ELMy H-mode plasma are developed by using two different approaches: a theory-based approaches and an empirical approach. For a theory-based approach, a model is developed based on the calculation of thermal energy in the pedestal region and on accepted scaling laws of energy confinement time. For an empirical model, a scaling law for pedestal temperature in terms of plasma controlled parameters, such as plasma current, magnetic field, heating power, is deduced from experimental data. Predictions from these models are compared with experimental data from the Pedestal International Database. Statistical quantities, such as Root-Mean Square Error (RMSE) and offset values, are computed to quantify the predictive capability of the models. It is found that the theory-based model predicts the pedestal temperature values moderately well yielding RMSE between 30% and 40%. The IPB98(y,3) scaling law yields with best agreement with RMSE of 30.4%. The empirical model predicts the pedestal temperature value with better agreement, yield RMSE of 25.9%

  11. Effects of Spironolactone and Losartan on Diabetic Nephropathy in a Type 2 Diabetic Rat Model

    Directory of Open Access Journals (Sweden)

    Mi Young Lee

    2011-04-01

    Full Text Available BackgroundWhile there is an evidence that the anti-inflammatory properties of spironolactone can attenuate proteinuria in type 2 diabetes, its effects on vascular endothelial growth factor (VEGF expression in diabetic nephropathy have not been clearly defined. In this study, we examined the effects of spironolactone, losartan, and a combination of these two drugs on albuminuria, renal VEGF expression, and inflammatory and oxidative stress markers in a type 2 diabetic rat model.MethodsThirty-three Otsuka-Long-Evans-Tokushima-Fatty (OLETF rats were divided into four groups and treated with different medication regimens from weeks 25 to 50; OLETF diabetic controls (n=5, spironolactone-treated (n=10, losartan-treated (n=9, and combination of spironolactone- and losartan-treated (n=9.ResultsAt week 50, the albumin-to-creatinine ratio was significantly decreased in the losartan and combination groups compared to the control OLETF group. No decrease was detected in the spironolactone group. There was a significant reduction in renal VEGF, transforming growth factor (TGF-β, and type IV collagen mRNA levels in the spironolactone- and combination regimen-treated groups. Twenty-four hour urine monocyte chemotactic protein-1 levels were comparable in all four groups but did show a decreasing trend in the losartan and combination regimen groups. Twenty-four hour urine malondialdehyde levels were significantly decreased in the spironolactone- and combination regimen-treated groups.ConclusionThese results suggest that losartan alone and a combined regimen of spironolactone and losartan could ameliorate albuninuria by reducing renal VEGF expression. Also, simultaneous treatment with spironolactone and losartan may have protective effects against diabetic nephropathy by decreasing TGF-β and type IV collagen expression and by reducing oxidative stress in a type 2 diabetic rat model.

  12. A murine model of type 2 autoimmune hepatitis: Xenoimmunization with human antigens.

    Science.gov (United States)

    Lapierre, Pascal; Djilali-Saiah, Idriss; Vitozzi, Susana; Alvarez, Fernando

    2004-04-01

    Autoimmune hepatitis (AIH) is characterized by an immune-mediated injury of the hepatic parenchyma of unknown pathogenesis. Type 2 AIH is identified by the presence of anti-liver-kidney microsomes type 1 (anti-LKM1) and anti-liver cytosol type 1 (anti-LC1) autoantibodies. The current study shows that a murine model of AIH can be generated by DNA immunization against type 2 AIH self-antigens (P450 2D6 and formiminotransferase-cyclodeaminase). A pCMV plasmid containing the N-terminal region of mouse CTLA-4 and the antigenic region of human CYP2D6 (672-1,377 bp) and human formiminotransferase cyclodeaminase (FTCD; 1,232-1,668 bp) was used for DNA immunization of C57BL/6 female mice. Immunized mice showed elevated levels of alanine aminotransferase (ALT), with peaks at 4 and 7 months postinjection. Periportal, portal, and intralobular liver inflammatory infiltrates were observed at histology. Mainly CD4+ lymphocytes, but also CD8+ and B lymphocytes, were found in the liver. Cytotoxic-specific T cells were found in both the liver and spleen of these animals. Mice developed anti-LKM1 and anti-LC1 antibodies of immunoglobulin G2 (IgG2) subclass, against specific mouse autoantigens. The ALT levels correlated with both the presence of anti-LKM1/anti-LC1 antibodies and the presence of liver necroinflammation. In conclusion, in mice, DNA immunization against human autoantigens breaks tolerance and induces an autoimmune liver disease. Molecular mimicry between foreign and self-antigens explains the liver injury. This model of AIH resembles human type 2 AIH and will be helpful for the study of its pathogenesis.

  13. A fuzzy chance-constrained programming model with type 1 and type 2 fuzzy sets for solid waste management under uncertainty

    Science.gov (United States)

    Ma, Xiaolin; Ma, Chi; Wan, Zhifang; Wang, Kewei

    2017-06-01

    Effective management of municipal solid waste (MSW) is critical for urban planning and development. This study aims to develop an integrated type 1 and type 2 fuzzy sets chance-constrained programming (ITFCCP) model for tackling regional MSW management problem under a fuzzy environment, where waste generation amounts are supposed to be type 2 fuzzy variables and treated capacities of facilities are assumed to be type 1 fuzzy variables. The evaluation and expression of uncertainty overcome the drawbacks in describing fuzzy possibility distributions as oversimplified forms. The fuzzy constraints are converted to their crisp equivalents through chance-constrained programming under the same or different confidence levels. Regional waste management of the City of Dalian, China, was used as a case study for demonstration. The solutions under various confidence levels reflect the trade-off between system economy and reliability. It is concluded that the ITFCCP model is capable of helping decision makers to generate reasonable waste-allocation alternatives under uncertainties.

  14. In-pile modelling of nuclear fuel element for the MTR type reactors. Pt. 2

    Energy Technology Data Exchange (ETDEWEB)

    Farhadi, Kazem [AEOI, Tehran (Iran, Islamic Republic of). Radiations Application Research School

    2014-06-15

    In part two of the present paper, neutronic properties of the pool-type research reactor core are used to assess the similitude laws derived for out-of-pile modelling of the fuel element. The benchmark reactor used for this purpose is an IAEA 5 MW thermal pool-type research reactor currently in operation. The neutronic properties analysis are based on typical 2 200 m/sec and neutrons having 0.025 eV energy. The non-leakage capability of the system is estimated in terms of diffusion length. Also the slowing down power and the moderating ratio of the modelled methanol coolant are calculated in terms of lethargy of the diffusing medium. It is shown that the Iron which is substituted for Aluminium cladding is a relatively low absorber of neutrons but has a high neutron leakage. Methanol which replaced ordinary water as coolant is not a suitable coolant due to high neutrons absorbing substance. It is concluded that although Iron as a cladding material and methanol as a coolant meet the modelling out-of-pile criteria but are not satisfying neutronic properties. Therefore, use of them as a model clad and coolant are not suggested for research reactors. (orig.)

  15. Continuum Gyrokinetic Simulations of Turbulence in a Helical Model SOL with NSTX-type parameters

    Science.gov (United States)

    Hammett, G. W.; Shi, E. L.; Hakim, A.; Stoltzfus-Dueck, T.

    2017-10-01

    We have developed the Gkeyll code to carry out 3D2V full- F gyrokinetic simulations of electrostatic plasma turbulence in open-field-line geometries, using special versions of discontinuous-Galerkin algorithms to help with the computational challenges of the edge region. (Higher-order algorithms can also be helpful for exascale computing as they reduce the ratio of communications to computations.) Our first simulations with straight field lines were done for LAPD-type cases. Here we extend this to a helical model of an SOL plasma and show results for NSTX-type parameters. These simulations include the basic elements of a scrape-off layer: bad-curvature/interchange drive of instabilities, narrow sources to model plasma leaking from the core, and parallel losses with model sheath boundary conditions (our model allows currents to flow in and out of the walls). The formation of blobs is observed. By reducing the strength of the poloidal magnetic field, the heat flux at the divertor plate is observed to broaden. Supported by the Max-Planck/Princeton Center for Plasma Physics, the SciDAC Center for the Study of Plasma Microturbulence, and DOE Contract DE-AC02-09CH11466.

  16. Modeling Niemann Pick type C1 using human embryonic and induced pluripotent stem cells.

    Science.gov (United States)

    Ordoñez, M Paulina; Steele, John W

    2017-02-01

    Data generated in Niemann Pick type C1 (NPC1) human embryonic and human induced pluripotent stem cell derived neurons complement on-going studies in animal models and provide the first example, in disease-relevant human cells, of processes that underlie preferential neuronal defects in a NPC1. Our work and that of other investigators in human neurons derived from stem cells highlight the importance of performing rigorous mechanistic studies in relevant cell types to guide drug discovery and therapeutic development, alongside of existing animal models. Through the use of human stem cell-derived models of disease, we can identify and discover or repurpose drugs that revert early events that lead to neuronal failure in NPC1. Together with the study of disease pathogenesis and efficacy of therapies in animal models, these strategies will fulfill the promise of stem cell technology in the development of new treatments for human diseases. This article is part of a Special Issue entitled SI: Exploiting human neurons. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Development of mapped stress-field boundary conditions based on a Hill-type muscle model.

    Science.gov (United States)

    Cardiff, P; Karač, A; FitzPatrick, D; Flavin, R; Ivanković, A

    2014-09-01

    Forces generated in the muscles and tendons actuate the movement of the skeleton. Accurate estimation and application of these musculotendon forces in a continuum model is not a trivial matter. Frequently, musculotendon attachments are approximated as point forces; however, accurate estimation of local mechanics requires a more realistic application of musculotendon forces. This paper describes the development of mapped Hill-type muscle models as boundary conditions for a finite volume model of the hip joint, where the calculated muscle fibres map continuously between attachment sites. The applied muscle forces are calculated using active Hill-type models, where input electromyography signals are determined from gait analysis. Realistic muscle attachment sites are determined directly from tomography images. The mapped muscle boundary conditions, implemented in a finite volume structural OpenFOAM (ESI-OpenCFD, Bracknell, UK) solver, are employed to simulate the mid-stance phase of gait using a patient-specific natural hip joint, and a comparison is performed with the standard point load muscle approach. It is concluded that physiological joint loading is not accurately represented by simplistic muscle point loading conditions; however, when contact pressures are of sole interest, simplifying assumptions with regard to muscular forces may be valid. Copyright © 2014 John Wiley & Sons, Ltd.

  18. Role of different types of solid models in hydrodynamic modeling and their effects on groundwater protection processes

    Science.gov (United States)

    Bódi, Erika; Buday, Tamás; McIntosh, Richard William

    2013-04-01

    handle pinching out lithological units and lenticular bodies easier while most hydrodynamic softwares cannot handle flow units related to such model layers. Interpretation of tectonic disturbance is similar. In Hungary groundwater is extracted mainly from Pleistocene and Pannonian aquifers sediments of which were deposited in the ancient Pannonian Lake. When the basin lost its open-marine connection eustasy had no direct effects on facies changes therefore subsidence and sediment supply became the main factors. Various basin-filling related facies developed including alluvial plain facies, different delta facies types and pelitic deep-basin facies. Creating solid models based on sequence stratigraphic methods requires more raw data and also genetic approaches, in addition more working hours hence this method is seldom used in practice. Lithology-based models can be transformed into sequence stratigraphic models by extending the data base (e.g. detecting more survey data). In environments where the obtained models differ significantly notable changes can occur in the supply directions in addition the groundwater travel-time of the two models even on equal extraction terms. Our study aims to call attention to the consequences of using different solid models for typical depositional systems of the Great Hungarian Plain and to their effects on groundwater protection.

  19. Improved double-multiple streamtube model for the Darrieus-type vertical axis wind turbine

    Science.gov (United States)

    Berg, D. E.

    Double streamtube codes model the curved blade (Darrieus-type) vertical axis wind turbine (VAWT) as a double actuator fish arrangement (one half) and use conservation of momentum principles to determine the forces acting on the turbine blades and the turbine performance. Sandia National Laboratories developed a double multiple streamtube model for the VAWT which incorporates the effects of the incident wind boundary layer, nonuniform velocity between the upwind and downwind sections of the rotor, dynamic stall effects and local blade Reynolds number variations. The theory underlying this VAWT model is described, as well as the code capabilities. Code results are compared with experimental data from two VAWT's and with the results from another double multiple streamtube and a vortex filament code. The effects of neglecting dynamic stall and horizontal wind velocity distribution are also illustrated.

  20. Applied model of through-wall crack of coolant vessels of WWER-type reactors

    International Nuclear Information System (INIS)

    Petrosyan, V.; Hovakimyan, T.; Vardanyan, M.; Khachatryan, A.; Minasyan, K.

    2010-01-01

    We propose an applied-model of Through-Wall Crack (TWC) for WWER-type units primary vessels. The model allows to simulate the main morphological parameters of real TWC, i.e. length, area of inlet and outlet openings, channel depth and small and large size unevenness of the crack surface. The model can be used for developing and improving the coolant-leak detectors for the primary circuit vessels of WWER-units. Also, it can be used for research of the coolant two-phase leakage phenomenon through narrow cracks/channels and thermo-physical processes in heat-insulation layer of the Main Coolant Piping (MCP) during the leak

  1. Assessment of Model Predictive and Adaptive Glucose Control Strategies for People with Type 1 Diabetes

    DEFF Research Database (Denmark)

    Boiroux, Dimitri; Duun-Henriksen, Anne Katrine; Schmidt, Signe

    2014-01-01

    This paper addresses overnight blood glucose stabilization in people with type 1 diabetes using a Model Predictive Controller (MPC). We use a control strategy based on an adaptive ARMAX model in which we use a Recursive Extended Least Squares (RELS) method to estimate parameters of the stochastic...... and reduce the risk of hypoglycemia. We test our control strategies on a virtual clinic of 100 randomly generated patients with a representative inter-subject variability. This virtual clinic is based on the Hovorka model. We consider the case where only half of the meal bolus is administered at mealtime......, and the case where the insulin sensitivity varies during the night. The simulation results demonstrate that the adaptive control strategy can reduce the risks of hypoglycemia and hyperglycemia during the night....

  2. A Generic Safety Assessment Model for a Trench Type LILW Repository

    International Nuclear Information System (INIS)

    Lee, Youn-Myoung; Choi, Hee-Joo

    2015-01-01

    This program is ready for a total system performance assessment and is able to deterministically and probabilistically evaluate the nuclide release from a repository and farther transport into the geosphere and biosphere under various normal circumstances, disruptive events, and scenarios that can occur after a failure of waste packages with associated uncertainty. Despite the conceptual design of a trench type LILW repository system, all parameter values associated with the repository system were assumed for the time being, and the generic model developed through this study should be helpful because the evaluation of such releases is very important. A simple and effective model for a safety assessment of a conceptual trench repository system, in which an LILW that arises from a nuclear power plant and other sources, has been developed. The computer program based on this model has also been developed as a GoldSim template using the commercial GoldSim development tool

  3. A Generic Safety Assessment Model for a Trench Type LILW Repository

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Youn-Myoung; Choi, Hee-Joo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    This program is ready for a total system performance assessment and is able to deterministically and probabilistically evaluate the nuclide release from a repository and farther transport into the geosphere and biosphere under various normal circumstances, disruptive events, and scenarios that can occur after a failure of waste packages with associated uncertainty. Despite the conceptual design of a trench type LILW repository system, all parameter values associated with the repository system were assumed for the time being, and the generic model developed through this study should be helpful because the evaluation of such releases is very important. A simple and effective model for a safety assessment of a conceptual trench repository system, in which an LILW that arises from a nuclear power plant and other sources, has been developed. The computer program based on this model has also been developed as a GoldSim template using the commercial GoldSim development tool.

  4. A model for phase evolution and volume expansion in tube type Nb3Sn conductors

    Science.gov (United States)

    Xu, X.; Sumption, M. D.; Collings, E. W.

    2013-12-01

    In this work, an analytic model for phase formation and volume expansion during heat treatment in tube type Nb3Sn strands is presented. Tube type Nb3Sn conductors consist of Nb or Nb-Ta alloy tube with a simple Cu/Sn binary metal insert to form the basic subelement (filament). A number of these elements, each with an outer Cu jacket, are restacked to form a multifilamentary strand. The present tube type conductors, with 4.2 K, 12 T non-Cu critical current density (Jc) in the 2000-2500 A mm-2 range and effective subelement diameters (deff) in the 12-36 μm range, are of interest for a number of applications. During the reaction of typical tube type strands, the Sn-Cu becomes molten and reacts with the Nb tube first to form NbSn2, then Nb6Sn5. At later times in the reaction sequence, all of the NbSn2 and Nb6Sn5 is converted to Nb3Sn. Some of the Nb3Sn is formed by a Nb-Sn reaction and has a fine grain (FG) structure, while some is converted from Nb6Sn5, which results in a coarse grain (CG) region. The fractions of FG and CG A15 are important in determining the final conductor properties. In this work we develop an analytic model to predict the radial extents of the various phases, and in particular the final FG and CG fractions based on the starting Nb, Cu, and Sn amounts in the subelements. The model is then compared to experimental results and seen to give reasonable agreement. By virtue of this model we outline an approach to minimize the CG regions in tube type and PIT strands and maximize the final FG area fractions. Furthermore, the volume change during the various reaction stages was also studied. It is proposed that the Sn content in the Cu-Sn alloy has a crucial influence on the radial expansion.

  5. A practical approach to model checking Duration Calculus using Presburger Arithmetic

    DEFF Research Database (Denmark)

    Hansen, Michael Reichhardt; Dung, Phan Anh; Brekling, Aske Wiid

    2014-01-01

    This paper investigates the feasibility of reducing a model-checking problem K ⊧ ϕ for discrete time Duration Calculus to the decision problem for Presburger Arithmetic. Theoretical results point at severe limitations of this approach: (1) the reduction in Fränzle and Hansen (Int J Softw Inform 3...... limits of the approach are illustrated by a family of examples....

  6. Avaliação do programa de controle da hanseníase em um município hiperendêmico do Estado do Maranhão, Brasil, 1991-1995

    Directory of Open Access Journals (Sweden)

    Aquino Dorlene Maria Cardoso de

    2003-01-01

    Full Text Available Estudo descritivo, objetivando avaliar o programa de controle da hanseníase do Município de Buriticupu, Maranhão. Foram analisados 214 prontuários de pacientes portadores das diversas formas clínicas de hanseníase, atendidos na unidade de saúde da Universidade Federal do Maranhão, localizada no referido município. A população de estudo foi constituída de 110 casos de hanseníase das formas paucibacilares (PB e 104 das formas multibacilares (MB registrados no período de janeiro de 1991 a dezembro de 1995. As informações referentes à forma clínica, número de contatos registrados, examinados e avaliados, grau de incapacidade no início e final do tratamento e situação de registro, foram coletadas num formulário específico. A análise dos resultados foi baseada nos parâmetros dos indicadores operacionais definidos pelo Ministério da Saúde. Houve um discreto predomínio da forma PB da doença. Observou-se baixos percentuais em relação aos pacientes com grau de incapacidade física avaliada no início e final do tratamento, a alta por cura e contatos examinados. O percentual de abandono foi elevado. O programa foi considerado "precário" em todos os indicadores utilizados para o estudo.

  7. Establishment of a canine model of human type 2 diabetes mellitus by overexpressing phosphoenolypyruvate carboxykinase.

    Science.gov (United States)

    Jeong, Yeon Woo; Lee, Geun-Shik; Kim, Joung Joo; Park, Sun Woo; Ko, Kyeong Hee; Kang, Mina; Kim, Yu Kyung; Jung, Eui-Man; Hyun, Sang Hwan; Shin, Taeyoung; Jeung, Eui-Bae; Hwang, Woo Suk

    2012-08-01

    Dogs are useful models for studying human metabolic diseases such as type 2 diabetes mellitus due to similarities in physiology, anatomy and life styles with humans. Somatic cell nuclear transfer (SCNT) facilitates the production of transgenic dogs. In this study, we generated transgenic dogs expressing the phosphoenolpyruvate carboxykinase (PEPCK) gene, which is closely involved in the pathogenesis of type 2 diabetes mellitus. In addition, we assessed the cloning efficiency associated with adult or fetal (cloned or natural mating) fibroblasts as a nuclear source. Cloning efficiency was determined by the fusion, pregnancy and cloning rates. The fusion rates were significantly high for fibroblasts from cloned fetuses, but the pregnancy and cloning rates were relatively high for cells from normal fetuses. Based on these data, fetal fibroblasts were selected as the nuclear donor for SCNT and genetically engineered to overexpress the PEPCK gene and dual selection marker genes controlled by the PEPCK promoter. The transgenic cells were introduced into oocytes and transferred into five recipient dogs, resulting in two pregnancies. Finally, three puppies were born and confirmed by microsatellite analysis to be genetically identical to the donor. One puppy successfully overexpressed PEPCK mRNA and protein in the liver. This canine disease model may be useful for studying the pathogenesis and/or therapeutic targets of type 2 diabetes mellitus.

  8. An estimation framework for building information modeling (BIM)-based demolition waste by type.

    Science.gov (United States)

    Kim, Young-Chan; Hong, Won-Hwa; Park, Jae-Woo; Cha, Gi-Wook

    2017-12-01

    Most existing studies on demolition waste (DW) quantification do not have an official standard to estimate the amount and type of DW. Therefore, there are limitations in the existing literature for estimating DW with a consistent classification system. Building information modeling (BIM) is a technology that can generate and manage all the information required during the life cycle of a building, from design to demolition. Nevertheless, there has been a lack of research regarding its application to the demolition stage of a building. For an effective waste management plan, the estimation of the type and volume of DW should begin from the building design stage. However, the lack of tools hinders an early estimation. This study proposes a BIM-based framework that estimates DW in the early design stages, to achieve an effective and streamlined planning, processing, and management. Specifically, the input of construction materials in the Korean construction classification system and those in the BIM library were matched. Based on this matching integration, the estimates of DW by type were calculated by applying the weight/unit volume factors and the rates of DW volume change. To verify the framework, its operation was demonstrated by means of an actual BIM modeling and by comparing its results with those available in the literature. This study is expected to contribute not only to the estimation of DW at the building level, but also to the automated estimation of DW at the district level.

  9. Modeling the Movement of Homicide by Type to Inform Public Health Prevention Efforts.

    Science.gov (United States)

    Zeoli, April M; Grady, Sue; Pizarro, Jesenia M; Melde, Chris

    2015-10-01

    We modeled the spatiotemporal movement of hotspot clusters of homicide by motive in Newark, New Jersey, to investigate whether different homicide types have different patterns of clustering and movement. We obtained homicide data from the Newark Police Department Homicide Unit's investigative files from 1997 through 2007 (n = 560). We geocoded the address at which each homicide victim was found and recorded the date of and the motive for the homicide. We used cluster detection software to model the spatiotemporal movement of statistically significant homicide clusters by motive, using census tract and month of occurrence as the spatial and temporal units of analysis. Gang-motivated homicides showed evidence of clustering and diffusion through Newark. Additionally, gang-motivated homicide clusters overlapped to a degree with revenge and drug-motivated homicide clusters. Escalating dispute and nonintimate familial homicides clustered; however, there was no evidence of diffusion. Intimate partner and robbery homicides did not cluster. By tracking how homicide types diffuse through communities and determining which places have ongoing or emerging homicide problems by type, we can better inform the deployment of prevention and intervention efforts.

  10. Maximum-likelihood model averaging to profile clustering of site types across discrete linear sequences.

    Directory of Open Access Journals (Sweden)

    Zhang Zhang

    2009-06-01

    Full Text Available A major analytical challenge in computational biology is the detection and description of clusters of specified site types, such as polymorphic or substituted sites within DNA or protein sequences. Progress has been stymied by a lack of suitable methods to detect clusters and to estimate the extent of clustering in discrete linear sequences, particularly when there is no a priori specification of cluster size or cluster count. Here we derive and demonstrate a maximum likelihood method of hierarchical clustering. Our method incorporates a tripartite divide-and-conquer strategy that models sequence heterogeneity, delineates clusters, and yields a profile of the level of clustering associated with each site. The clustering model may be evaluated via model selection using the Akaike Information Criterion, the corrected Akaike Information Criterion, and the Bayesian Information Criterion. Furthermore, model averaging using weighted model likelihoods may be applied to incorporate model uncertainty into the profile of heterogeneity across sites. We evaluated our method by examining its performance on a number of simulated datasets as well as on empirical polymorphism data from diverse natural alleles of the Drosophila alcohol dehydrogenase gene. Our method yielded greater power for the detection of clustered sites across a breadth of parameter ranges, and achieved better accuracy and precision of estimation of clusters, than did the existing empirical cumulative distribution function statistics.

  11. Double-detonation model of type Ia supernovae with a variable helium layer ignition mass

    International Nuclear Information System (INIS)

    Zhou Wei-Hong; Zhao Gang; Wang Bo

    2014-01-01

    Although Type Ia supernovae (SNe Ia) play an important role in the study of cosmology, their progenitors are still poorly understood. Thermonuclear explosions from the helium double-detonation sub-Chandrasekhar mass model have been considered as an alternative method for producing SNe Ia. By adopting the assumption that a double detonation occurs when a He layer with a critical ignition mass accumulates on the surface of a carbon—oxygen white dwarf (CO WD), we perform detailed binary evolution calculations for the He double-detonation model, in which a He layer from a He star accumulates on a CO WD. According to these calculations, we obtain the initial parameter spaces for SNe Ia in the orbital period and secondary mass plane for various initial WD masses. We implement these results into a detailed binary population synthesis approach to calculate SN Ia birthrates and delay times. From this model, the SN Ia birthrate in our Galaxy is ∼0.4 − 1.6 × 10 −3 yr −1 . This indicates that the double-detonation model only produces part of the SNe Ia. The delay times from this model are ∼ 70 – 710 Myr, which contribute to the young population of SNe Ia in the observations. We found that the CO WD + sdB star system CD–30 11223 could produce an SN Ia via the double-detonation model in its future evolution. (research papers)

  12. Cosmological parameter uncertainties from SALT-II type Ia supernova light curve models

    International Nuclear Information System (INIS)

    Mosher, J.; Sako, M.; Guy, J.; Astier, P.; Betoule, M.; El-Hage, P.; Pain, R.; Regnault, N.; Kessler, R.; Frieman, J. A.; Marriner, J.; Biswas, R.; Kuhlmann, S.; Schneider, D. P.

    2014-01-01

    We use simulated type Ia supernova (SN Ia) samples, including both photometry and spectra, to perform the first direct validation of cosmology analysis using the SALT-II light curve model. This validation includes residuals from the light curve training process, systematic biases in SN Ia distance measurements, and a bias on the dark energy equation of state parameter w. Using the SN-analysis package SNANA, we simulate and analyze realistic samples corresponding to the data samples used in the SNLS3 analysis: ∼120 low-redshift (z < 0.1) SNe Ia, ∼255 Sloan Digital Sky Survey SNe Ia (z < 0.4), and ∼290 SNLS SNe Ia (z ≤ 1). To probe systematic uncertainties in detail, we vary the input spectral model, the model of intrinsic scatter, and the smoothing (i.e., regularization) parameters used during the SALT-II model training. Using realistic intrinsic scatter models results in a slight bias in the ultraviolet portion of the trained SALT-II model, and w biases (w input – w recovered ) ranging from –0.005 ± 0.012 to –0.024 ± 0.010. These biases are indistinguishable from each other within the uncertainty; the average bias on w is –0.014 ± 0.007.

  13. Cosmological Parameter Uncertainties from SALT-II Type Ia Supernova Light Curve Models

    Energy Technology Data Exchange (ETDEWEB)

    Mosher, J. [Pennsylvania U.; Guy, J. [LBL, Berkeley; Kessler, R. [Chicago U., KICP; Astier, P. [Paris U., VI-VII; Marriner, J. [Fermilab; Betoule, M. [Paris U., VI-VII; Sako, M. [Pennsylvania U.; El-Hage, P. [Paris U., VI-VII; Biswas, R. [Argonne; Pain, R. [Paris U., VI-VII; Kuhlmann, S. [Argonne; Regnault, N. [Paris U., VI-VII; Frieman, J. A. [Fermilab; Schneider, D. P. [Penn State U.

    2014-08-29

    We use simulated type Ia supernova (SN Ia) samples, including both photometry and spectra, to perform the first direct validation of cosmology analysis using the SALT-II light curve model. This validation includes residuals from the light curve training process, systematic biases in SN Ia distance measurements, and a bias on the dark energy equation of state parameter w. Using the SN-analysis package SNANA, we simulate and analyze realistic samples corresponding to the data samples used in the SNLS3 analysis: ~120 low-redshift (z < 0.1) SNe Ia, ~255 Sloan Digital Sky Survey SNe Ia (z < 0.4), and ~290 SNLS SNe Ia (z ≤ 1). To probe systematic uncertainties in detail, we vary the input spectral model, the model of intrinsic scatter, and the smoothing (i.e., regularization) parameters used during the SALT-II model training. Using realistic intrinsic scatter models results in a slight bias in the ultraviolet portion of the trained SALT-II model, and w biases (w (input) – w (recovered)) ranging from –0.005 ± 0.012 to –0.024 ± 0.010. These biases are indistinguishable from each other within the uncertainty, the average bias on w is –0.014 ± 0.007.

  14. Modeling Occurrence of Urban Mosquitos Based on Land Use Types and Meteorological Factors in Korea

    Directory of Open Access Journals (Sweden)

    Yong-Su Kwon

    2015-10-01

    Full Text Available Mosquitoes are a public health concern because they are vectors of pathogen, which cause human-related diseases. It is well known that the occurrence of mosquitoes is highly influenced by meteorological conditions (e.g., temperature and precipitation and land use, but there are insufficient studies quantifying their impacts. Therefore, three analytical methods were applied to determine the relationships between urban mosquito occurrence, land use type, and meteorological factors: cluster analysis based on land use types; principal component analysis (PCA based on mosquito occurrence; and three prediction models, support vector machine (SVM, classification and regression tree (CART, and random forest (RF. We used mosquito data collected at 12 sites from 2011 to 2012. Mosquito abundance was highest from August to September in both years. The monitoring sites were differentiated into three clusters based on differences in land use type such as culture and sport areas, inland water, artificial grasslands, and traffic areas. These clusters were well reflected in PCA ordinations, indicating that mosquito occurrence was highly influenced by land use types. Lastly, the RF represented the highest predictive power for mosquito occurrence and temperature-related factors were the most influential. Our study will contribute to effective control and management of mosquito occurrences.

  15. Bianchi Type I Cosmological Models in Eddington-inspired Born–Infeld Gravity

    Directory of Open Access Journals (Sweden)

    Tiberiu Harko

    2014-10-01

    Full Text Available We consider the dynamics of a barotropic cosmological fluid in an anisotropic, Bianchi type I space-time in Eddington-inspired Born–Infeld (EiBI gravity. By assuming isotropic pressure distribution, we obtain the general solution of the field equations in an exact parametric form. The behavior of the geometric and thermodynamic parameters of the Bianchi type I Universe is studied, by using both analytical and numerical methods, for some classes of high density matter, described by the stiff causal, radiation, and pressureless fluid equations of state. In all cases the study of the models with different equations of state can be reduced to the integration of a highly nonlinear second order ordinary differential equation for the energy density. The time evolution of the anisotropic Bianchi type I Universe strongly depends on the initial values of the energy density and of the Hubble function. An important observational parameter, the mean anisotropy parameter, is also studied in detail, and we show that for the dust filled Universe the cosmological evolution always ends into isotropic phase, while for high density matter filled universes the isotropization of Bianchi type I universes is essentially determined by the initial conditions of the energy density.

  16. Aspectos da doença de hansen relevantes para o cirurgião-dentista: revisão da literatura = Relevant aspects of hansen’s disease to dentists: literature review

    Directory of Open Access Journals (Sweden)

    Russo, Michelle Pereira

    2005-01-01

    Full Text Available Tendo em vista o elevado número de casos de Doença de Hansen no Brasil, caracterizando um problema de saúde pública, o presente trabalho teve como objetivo realizar uma revisão bibliográfica visando informar o cirurgião-dentista sobre a situação atual da DH no Brasil, suas manifestações bucais, seqüelas que repercutem na saúde bucal e dar subsídios para que o profissional participe do diagnóstico desta doença

  17. Estudo comparativo preliminar entre os alongamentos proprioceptivo e estático passivo em pacientes com seqüelas de hanseníase Preliminary comparative study between proprioceptive and passive static stretching in patients with leprosy sequelae

    OpenAIRE

    Augusto Floricel Diaz; Fabio Luiz Moro; Jussara Machado Binotto; Andersom Ricardo Fréz

    2008-01-01

    A proposta deste estudo foi comparar a aplicação de alongamento estático passivo e alongamento proprioceptivo no tratamento de seqüelas de hanseníase. Doze pacientes com essas seqüelas participaram da pesquisa, separados aleatoriamente em dois grupos: o grupo FNP, tratado com facilitação neuromuscular proprioceptiva, e o grupo AEP, com alongamento estático passivo. Ambos realizaram dez sessões de alongamentos, sendo submetidos à avaliação inicial e final nas quais foram aplicados o questionár...

  18. Verificação da infecção de moscas da família Tachinidae pela Empusa Cohn, 1855: essas moscas, sugando ulceras lepróticas, se infestaram com o bacilo de Hansen

    Directory of Open Access Journals (Sweden)

    H. C. de Souza-Araujo

    1944-08-01

    Full Text Available The A. refers that, in his last study, in his last studying trip to Colonia Santa Fé, Minas Gerais State, last month of March (autumn, had captured many wild flies (all from Tachinidae family, according to various entomologists of the Instituto Oswaldo Cruz, on a leprotic ulceration of the left leg of a lepromatous case of leprosy. The microscopical examination of the abdominal material from sch flies proved the presence, in rather great number, of HANSEN bacilli and a fungus of the genus Empusa COHN 1855. The A. intends to continue, next summer, such interesting research.

  19. Assessing parameter variability in a photosynthesis model within and between plant functional types using global Fluxnet eddy covariance data

    NARCIS (Netherlands)

    Groenendijk, M.; Dolman, A.J.; Molen, van der M.K.; Leuning, R.; Arneth, A.; Delpierre, N.; Gash, J.H.C.; Lindroth, A.; Richardson, A.D.; Verbeeck, H.; Wohlfahrt, G.

    2011-01-01

    The vegetation component in climate models has advanced since the late 1960s from a uniform prescription of surface parameters to plant functional types (PFTs). PFTs are used in global land-surface models to provide parameter values for every model grid cell. With a simple photosynthesis model we

  20. Modelling a reliability system governed by discrete phase-type distributions

    International Nuclear Information System (INIS)

    Ruiz-Castro, Juan Eloy; Perez-Ocon, Rafael; Fernandez-Villodre, Gemma

    2008-01-01

    We present an n-system with one online unit and the others in cold standby. There is a repairman. When the online fails it goes to repair, and instantaneously a standby unit becomes the online one. The operational and repair times follow discrete phase-type distributions. Given that any discrete distribution defined on the positive integers is a discrete phase-type distribution, the system can be considered a general one. A model with unlimited number of units is considered for approximating a system with a great number of units. We show that the process that governs the system is a quasi-birth-and-death process. For this system, performance reliability measures; the up and down periods, and the involved costs are calculated in a matrix and algorithmic form. We show that the discrete case is not a trivial case of the continuous one. The results given in this paper have been implemented computationally with Matlab

  1. Modelling a reliability system governed by discrete phase-type distributions

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz-Castro, Juan Eloy [Departamento de Estadistica e Investigacion Operativa, Universidad de Granada, 18071 Granada (Spain)], E-mail: jeloy@ugr.es; Perez-Ocon, Rafael [Departamento de Estadistica e Investigacion Operativa, Universidad de Granada, 18071 Granada (Spain)], E-mail: rperezo@ugr.es; Fernandez-Villodre, Gemma [Departamento de Estadistica e Investigacion Operativa, Universidad de Granada, 18071 Granada (Spain)

    2008-11-15

    We present an n-system with one online unit and the others in cold standby. There is a repairman. When the online fails it goes to repair, and instantaneously a standby unit becomes the online one. The operational and repair times follow discrete phase-type distributions. Given that any discrete distribution defined on the positive integers is a discrete phase-type distribution, the system can be considered a general one. A model with unlimited number of units is considered for approximating a system with a great number of units. We show that the process that governs the system is a quasi-birth-and-death process. For this system, performance reliability measures; the up and down periods, and the involved costs are calculated in a matrix and algorithmic form. We show that the discrete case is not a trivial case of the continuous one. The results given in this paper have been implemented computationally with Matlab.

  2. Late time optical spectra from the /sup 56/Ni model for Type I supernovae

    Energy Technology Data Exchange (ETDEWEB)

    Axelrod, T.S.

    1980-07-01

    The hypothesis that the optical luminosity of Type I supernovae results from the radioactive decay of /sup 56/Ni synthesized and ejected by the explosion has been investigated by numerical simulation of the optical spectrum resulting from a homologously expanding shell composed initially of pure /sup 56/Ni core. This model, which neglects the effects of material external to the /sup 56/Ni core, is expected to provide a reasonable representation of the supernova at late times when the star is nearly transparent to optical photons. The numerical simulation determines the temperature, ionization state, and non-LTE level populations which result from energy deposition by the radioactive decay products of /sup 56/Ni and /sup 56/Co. The optical spectrum includes the effects of both allowed and forbidden lines. The optical spectra resulting from the simulation are found to be sensitive to the mass and ejection velocity of the /sup 56/Ni shell. A range of these parameters has been found which results in good agreement with the observed spectra of SN1972e over a considerable range of time. In particular, evidence for the expected decaying abundance of /sup 56/Co has been found in the spectra of SN1972e. These results are used to assess the validity of the /sup 56/Ni model and set limits on the mass and explosion mechanism of the Type I progenitor. The possibilities for improvement of the numerical model are discussed and future atomic data requirements defined.

  3. Damage and failure modeling of lotus-type porous material subjected to low-cycle fatigue

    Directory of Open Access Journals (Sweden)

    J. Kramberger

    2016-01-01

    Full Text Available The investigation of low-cycle fatigue behaviour of lotus-type porous material is presented in this paper. Porous materials exhibit some unique features which are useful for a number of various applications. This paper evaluates a numerical approach for determining of damage initiation and evolution of lotus-type porous material with computational simulations, where the considered computational models have different pore topology patterns. The low-cycle fatigue analysis was performed by using a damage evolution law. The damage state was calculated and updated based on the inelastic hysteresis energy for stabilized cycle. Degradation of the elastic stifness was modeled using scalar damage variable. In order to examine crack propagation path finite elements with severe damage were deleted and removed from the mesh during simulation. The direct cyclic analysis capability in Abaqus/Standard was used for low-cycle fatigue analysis to obtain the stabilized response of a model subjected to the periodic loading. The computational results show a qualitative understanding of pores topology influence on low-cycle fatigue under transversal loading conditions in relation to pore orientation.

  4. Motivational Interview Method Based on Transtheoretical Model of Health Behaviour Change in Type 2 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Alime Selcuk Tosun

    2016-03-01

    Full Text Available Precautions taken in early stages of diabetes mellitus are more beneficial in terms of quality of life. The risk of Type 2 diabetes mellitus has been shown to be reduced at rates up to 58% or its emergence may be delayed with healthy lifestyle changes in different studies. Transtheoretical model and motivational interview method are especially used to increase the adaptation of individuals to disease management and to change behaviours about diabetes mellitus for decreasing or preventing the harmful effects of diabetes mellitus in studies conducted with individuals with Type 2 diabetes mellitus. Interventions using motivational interview method based on transtheoretical model demonstrated that a general improvement in glycaemic control and in physical activity level can be achieved and significant progress has been made during the stage of change. Motivational interview method based on transtheoretical model is an easy and efficient counselling method to reach behavioural change. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2016; 8(1: 32-41

  5. Late time optical spectra from the 56Ni model for Type I supernovae

    International Nuclear Information System (INIS)

    Axelrod, T.S.

    1980-07-01

    The hypothesis that the optical luminosity of Type I supernovae results from the radioactive decay of 56 Ni synthesized and ejected by the explosion has been investigated by numerical simulation of the optical spectrum resulting from a homologously expanding shell composed initially of pure 56 Ni core. This model, which neglects the effects of material external to the 56 Ni core, is expected to provide a reasonable representation of the supernova at late times when the star is nearly transparent to optical photons. The numerical simulation determines the temperature, ionization state, and non-LTE level populations which result from energy deposition by the radioactive decay products of 56 Ni and 56 Co. The optical spectrum includes the effects of both allowed and forbidden lines. The optical spectra resulting from the simulation are found to be sensitive to the mass and ejection velocity of the 56 Ni shell. A range of these parameters has been found which results in good agreement with the observed spectra of SN1972e over a considerable range of time. In particular, evidence for the expected decaying abundance of 56 Co has been found in the spectra of SN1972e. These results are used to assess the validity of the 56 Ni model and set limits on the mass and explosion mechanism of the Type I progenitor. The possibilities for improvement of the numerical model are discussed and future atomic data requirements defined

  6. Eliciting mixed emotions: A meta-analysis comparing models, types and measures.

    Directory of Open Access Journals (Sweden)

    Raul eBerrios

    2015-04-01

    Full Text Available The idea that people can experience two oppositely valenced emotions has been controversial ever since early attempts to investigate the construct of mixed emotions. This meta-analysis examined the robustness with which mixed emotions have been elicited experimentally. A systematic literature search identified 63 experimental studies that instigated the experience of mixed emotions. Studies were distinguished according to the structure of the underlying affect model – dimensional or discrete – as well as according to the type of mixed emotions studied (e.g., happy-sad, fearful-happy, positive-negative. The meta-analysis using a random-effects model revealed a moderate to high effect size for the elicitation of mixed emotions (dIG+ = .77, which remained consistent regardless of the structure of the affect model, and across different types of mixed emotions. Several methodological and design moderators were tested. Studies using the minimum index (i.e., the minimum value between a pair of opposite valenced affects resulted in smaller effect sizes, whereas subjective measures of mixed emotions increased the effect sizes. The presence of more women in the samples was also associated with larger effect sizes. The current study indicates that mixed emotions are a robust, measurable and non-artifactual experience. The results are discussed in terms of the implications for an affect system that has greater versatility and flexibility than previously thought.

  7. Mathematical model of the SOS response regulation in wild-type Escherichia coli

    International Nuclear Information System (INIS)

    Aksenov, S.V.

    1997-01-01

    Regulation of the SOS response in Escherichia coli, which is a set of inducible cellular reactions introduced after DNA damage, is due to specific interaction of LexA and RecA proteins. LexA protein is a common repressor of the genes of the SOS system, and RecA protein, once transiently activated by the so-called SOS-inducing signal, promotes LexA protein destruction. We have described the SOS regulation by means of differential equations with regard to LexA and RecA concentrations elsewhere. The 'input' function for model equations is the level of the SOS-inducing signal against time. Here we present a means for calculating the concentration of single-stranded DNA (SOS-inducing signal) as a function of time in wild-type cells after ultraviolet irradiation. With model equations one can simulate kinetic curves of SOS regulatory proteins after DNA damage to survey the SOS response kinetics. Simulation of LexA protein kinetics agrees with experimental data. We compare simulated LexA kinetic curves in wild-type and uνr - mutant bacteria, which is useful in investigating the way uνrABC-dependent excision repair modulates the SOS response kinetics. Possible applications of the model to investigating various aspects of the SOS induction are discussed

  8. Metallogenic model for continental volcanic-type rich and large uranium deposits

    International Nuclear Information System (INIS)

    Chen Guihua

    1998-01-01

    A metallogenic model for continental volcanic-type rich and large/super large uranium deposits has been established on the basis of analysis of occurrence features and ore-forming mechanism of some continental volcanic-type rich and large/super large uranium deposits in the world. The model proposes that uranium-enriched granite or granitic basement is the foundation, premetallogenic polycyclic and multistage volcanic eruptions are prerequisites, intense tectonic-extensional environment is the key for the ore formation, and relatively enclosed geologic setting is the reliable protection condition of the deposit. By using the model the author explains the occurrence regularities of some rich and large/super large uranium deposits such as Strelichof uranium deposit in Russia, Dornot uranium deposit in Mongolia, Olympic Dam Cu-U-Au-REE deposit in Australia, uranium deposit No.460 and Zhoujiashan uranium deposit in China, and then compares the above deposits with a large poor uranium deposit No.661 as well

  9. Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes

    Science.gov (United States)

    2013-01-01

    Background Dipeptidyl peptidase-4 (DPP-4) inhibitors modulate incretin hormones and exert anti-diabetic effects in type 2 diabetes mellitus. Treatment with angiotensin II type 1 receptor blockers (ARB) is a proven successful intervention for hypertension with type 2 diabetes. The present study investigated the combined effects of the DPP-4 inhibitor vildagliptin and the ARB valsartan in a mouse model of type 2 diabetes. Methods C57BL/6 J mice fed with high-fat diet (HFD) or db/db mice were treated with placebo, phloridzin (PHZ), vildagliptin alone (ViL), valsartan alone (VaL) or ViL with VaL (ViLVaL) for 8 weeks. Results Glucose metabolism was improved in response to PHZ, ViL and ViLVaL in both HFD and db/db mice. Upon glucose challenge, ViLVaL showed the greatest suppression of blood glucose excursions, with increased insulin secretion, in db/db mice. ViLVaL treatment also showed an improvement of insulin sensitivity in db/db mice. Serum inflammatory cytokines were significantly decreased, and adiponectin was highest, in the ViLVaL group. ViLVaL improved insulin signaling and attenuated stress signaling in liver with amelioration of hepatic steatosis due to activated fatty acid oxidation in db/db mice. Furthermore, immunohistochemical analysis of the pancreas revealed that the combination treatment resulted in an increased expression of insulin and PDX-1, and increased insulin content. Conclusions The combination therapy of ViL and VaL improves both pancreatic beta-cell function and insulin sensitivity, with a reduction of the inflammatory and cell stress milieu in mouse models of T2DM. Our results suggest that this combination therapy exerts additive or even synergistic benefits to treat T2DM. PMID:24188631

  10. Analysis of recent type Ia supernova data based on evolving dark energy models

    International Nuclear Information System (INIS)

    Park, Jaehong; Park, Chan-Gyung; Hwang, Jai-chan

    2011-01-01

    We study characters of recent type Ia supernova data using evolving dark energy models with changing equation-of-state parameter w. We consider a sudden-jump approximation of w for some chosen redshift spans with double transitions and constrain these models based on the Markov chain Monte Carlo method using the type Ia supernova data (Constitution, Union, Union2), together with the baryon acoustic oscillation A parameter and the cosmic microwave background shift parameter in a flat background. In the double-transition model, the Constitution data shows deviation outside 1σ from the Λ cold dark matter (ΛCDM) model at low (z < or approx. 0.2) and middle (0.2 < or approx. z < or approx. 0.4) redshift bins, whereas no such deviations are noticeable in the Union and Union2 data. By analyzing the Union members in the Constitution set, however, we show that the same difference is actually due to different calibration of the same Union sample in the Constitution set and is not due to new data added in the Constitution set. All detected deviations are within 2σ from the ΛCDM world model. From the ΛCDM mock data analysis, we quantify biases in the dark energy equation-of-state parameters induced by insufficient data with inhomogeneous distribution of data points in the redshift space and distance modulus errors. We demonstrate that the location of the peak in the distribution of arithmetic means (computed from the Markov chain Monte Carlo chain for each mock data) behaves as an unbiased estimator for the average bias, which is valid even for nonsymmetric likelihood distributions.

  11. Hydrological-niche models predict water plant functional group distributions in diverse wetland types.

    Science.gov (United States)

    Deane, David C; Nicol, Jason M; Gehrig, Susan L; Harding, Claire; Aldridge, Kane T; Goodman, Abigail M; Brookes, Justin D

    2017-06-01

    Human use of water resources threatens environmental water supplies. If resource managers are to develop policies that avoid unacceptable ecological impacts, some means to predict ecosystem response to changes in water availability is necessary. This is difficult to achieve at spatial scales relevant for water resource management because of the high natural variability in ecosystem hydrology and ecology. Water plant functional groups classify species with similar hydrological niche preferences together, allowing a qualitative means to generalize community responses to changes in hydrology. We tested the potential for functional groups in making quantitative prediction of water plant functional group distributions across diverse wetland types over a large geographical extent. We sampled wetlands covering a broad range of hydrogeomorphic and salinity conditions in South Australia, collecting both hydrological and floristic data from 687 quadrats across 28 wetland hydrological gradients. We built hydrological-niche models for eight water plant functional groups using a range of candidate models combining different surface inundation metrics. We then tested the predictive performance of top-ranked individual and averaged models for each functional group. Cross validation showed that models achieved acceptable predictive performance, with correct classification rates in the range 0.68-0.95. Model predictions can be made at any spatial scale that hydrological data are available and could be implemented in a geographical information system. We show the response of water plant functional groups to inundation is consistent enough across diverse wetland types to quantify the probability of hydrological impacts over regional spatial scales. © 2017 by the Ecological Society of America.

  12. The double-degenerate model for the progenitors of Type Ia supernovae

    Science.gov (United States)

    Liu, D.; Wang, B.; Han, Z.

    2018-02-01

    The double-degenerate (DD) model, involving the merging of massive double carbon-oxygen white dwarfs (CO WDs) driven by gravitational wave radiation, is one of the classical pathways for the formation of Type Ia supernovae (SNe Ia). Recently, it has been proposed that the WD+He subgiant channel has a significant contribution to the production of massive double WDs, in which the primary WD accumulates mass by accreting He-rich matter from an He subgiant. We evolved about 1800 CO WD+He star systems and obtained a large and dense grid for producing SNe Ia through the DD model. We then performed a series of binary population synthesis simulations for the DD model, in which the WD+He subgiant channel is calculated by interpolations in the SN Ia production grid. According to our standard model, the Galactic birth rate of SNe Ia is about 2.4 × 10- 3 yr- 1 for the WD+He subgiant channel of the DD model; the total birth rate is about 3.7 × 10- 3 yr- 1 for all channels, reproducing that of observations. Previous theoretical models still have deficit with the observed SNe Ia with delay times 8 Gyr. After considering the WD+He subgiant channel, we found that the delay time distributions are comparable with the observed results. Additionally, some recent studies proposed that the violent WD mergers are more likely to produce SNe Ia based on the DD model. We estimated that the violent mergers through the DD model may contribute to at most 16 per cent of all SNe Ia.

  13. Elucidating determinants of aerosol composition through particle-type-based receptor modeling

    Science.gov (United States)

    McGuire, M. L.; Jeong, C.-H.; Slowik, J. G.; Chang, R. Y.-W.; Corbin, J. C.; Lu, G.; Mihele, C.; Rehbein, P. J. G.; Sills, D. M. L.; Abbatt, J. P. D.; Brook, J. R.; Evans, G. J.

    2011-08-01

    An aerosol time-of-flight mass spectrometer (ATOFMS) was deployed at a semi-rural site in southern Ontario to characterize the size and chemical composition of individual particles. Particle-type-based receptor modelling of these data was used to investigate the determinants of aerosol chemical composition in this region. Individual particles were classified into particle-types and positive matrix factorization (PMF) was applied to their temporal trends to separate and cross-apportion particle-types to factors. The extent of chemical processing for each factor was assessed by evaluating the internal and external mixing state of the characteristic particle-types. The nine factors identified helped to elucidate the coupled interactions of these determinants. Nitrate-laden dust was found to be the dominant type of locally emitted particles measured by ATOFMS. Several factors associated with aerosol transported to the site from intermediate local-to-regional distances were identified: the Organic factor was associated with a combustion source to the north-west; the ECOC Day factor was characterized by nearby local-to-regional carbonaceous emissions transported from the south-west during the daytime; and the Fireworks factor consisted of pyrotechnic particles from the Detroit region following holiday fireworks displays. Regional aerosol from farther emissions sources was reflected through three factors: two Biomass Burning factors and a highly chemically processed Long Range Transport factor. The Biomass Burning factors were separated by PMF due to differences in chemical processing which were in part elucidated by the passage of two thunderstorm gust fronts with different air mass histories. The remaining two factors, ECOC Night and Nitrate Background, represented the night-time partitioning of nitrate to pre-existing particles of different origins. The distinct meteorological conditions observed during this month-long study in the summer of 2007 provided a unique

  14. Explanatory models of adult patients with type 2 diabetes mellitus from urban centers of central Ethiopia.

    Science.gov (United States)

    Habte, Bruck M; Kebede, Tedla; Fenta, Teferi G; Boon, Heather

    2016-09-13

    Type 2 diabetes, which is increasing as a public health problem in the low resource settings of Africa has been associated with the high prevalence of micro-vascular complications and increasing levels of macro-vascular complications. There is evidence from the developed world that understanding patient perceptions of chronic illness is important to design effective strategies for helping patients manage these conditions. This study utilized Kleinman's model to explore the illness perceptions of type 2 diabetes patients attending treatment in Addis Ababa and Butajira (Ethiopia) and better understand how they manage their illness. Qualitative interviews were conducted to elicit the explanatory models of purposively sampled type 2 diabetes patients attending treatment in three hospitals in central Ethiopia until saturation of key emerging themes was achieved. Analysis of interview transcripts was guided by Kleinman's model. A total of 39 participants, 24 from Addis Ababa and the rest from Butajira took part in the study. This study revealed that patients' explanatory models were informed by both the traditional and biomedical models with emotional distress evident in some of the participants. The traditional model seemed to reflect the strong religious and cultural influences for the majority of study participants. The findings also revealed that symptoms played significant roles in how patients viewed their illness including assessment of its severity. Most were uncertain about the cause of their illness, with those expressing certainty citing factors over which they believed they had little or no control. This may have contributed to the perceptions about the use of religious healing and traditional medicines in a complementary or alternative manner to the biomedical regimen which could affect their adherence to recommended regimens and their health outcomes. This study suggests the need for a strong diabetes care program that is sensitive to patients' experiences

  15. Late-intervention study with ebselen in an experimental model of type 1 diabetic nephropathy.

    Science.gov (United States)

    Tan, S M; Sharma, A; Stefanovic, N; de Haan, J B

    2015-03-01

    Previous studies have shown that preventive treatment with the antioxidant, ebselen, in experimental models of type 1 diabetic nephropathy resulted in an attenuation of structural and functional damage in the kidney. However, evidence for the effectiveness of ebselen in late-intervention studies is lacking. Thus, we aimed to investigate the effects of ebselen in attenuating established renal injury in type 1 diabetic nephropathy using the Akita mouse model. Baseline blood glucose and albumin-to-creatinine ratio (ACR) were measured in wild-type (WT) and heterozygous Akita mice at 9 weeks of age. At 10 weeks of age, WT and Akita mice were randomized to receive either vehicle (5% carboxymethyl cellulose) or ebselen by oral gavage at 10mg/kg twice daily. Kidney and urine were collected after 16 weeks of treatment with ebselen for histological and functional analyses. At 9 weeks of age, Akita mice displayed well-established renal dysfunction with significant increases in ACR and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels when compared with WT controls. After 16 weeks of treatment with ebselen, oxidative stress, as measured by nitrotyrosine immunostaining and urinary 8-OHdG levels, was significantly reduced in the Akita mice. Furthermore, gene expression of the major reactive oxygen species-producing nicotinamide adenine dinucleotide phosphate enzyme, Nox4, was also reduced by ebselen. However, ebselen had no effect on ACR and glomerulosclerosis. Chronic treatment with ebselen significantly reduced oxidative stress in the Akita mice. However, ebselen failed to attenuate functional or structural kidney damage in this late-intervention study using the Akita mouse model.

  16. High pressure thermal inactivation of Clostridium botulinum type E endospores – kinetic modeling and mechanistic insights

    Directory of Open Access Journals (Sweden)

    Christian Andreas Lenz

    2015-07-01

    Full Text Available Cold-tolerant, neurotoxigenic, endospore forming Clostridium (C. botulinum type E belongs to the non-proteolytic physiological C. botulinum group II, is primarily associated with aquatic environments, and presents a safety risk for seafood. High pressure thermal (HPT processing exploiting the synergistic effect of pressure and temperature can be used to inactivate bacterial endospores.We investigated the inactivation of C. botulinum type E spores by (near isothermal HPT treatments at 300 – 1200 MPa at 30 – 75 °C for 1 s – 10 min. The occurrence of heat and lysozyme susceptible spore fractions after such treatments was determined. The experimental data were modeled to obtain kinetic parameters and represented graphically by isoeffect lines. In contrast to findings for spores of other species and within the range of treatment parameters applied, zones of spore stabilization (lower inactivation than heat treatments alone, large heat susceptible (HPT-induced germinated or lysozyme-dependently germinable (damaged coat layer spore fractions were not detected. Inactivation followed 1st order kinetics. DPA release kinetics allowed for insights into possible inactivation mechanisms suggesting a (poorly effective physiologic-like (similar to nutrient-induced germination at ≤ 450 MPa/≤ 45 °C and non-physiological germination at >500 MPa/>60 – 70 °C.Results of this study support the existence of some commonalities in the HPT inactivation mechanism of C. botulinum type E spores and Bacillus spores although both organisms have significantly different HPT resistance properties. The information presented here contributes to closing the gap in knowledge regarding the HPT inactivation of spore formers relevant to food safety and may help industrial implementation of HPT processing. The markedly lower HPT resistance of C. botulinum type E spores than spores from other C. botulinum types, could allow for the implementation of milder processes without

  17. Impairment of Vision in a Mouse Model of Usher Syndrome Type III.

    Science.gov (United States)

    Tian, Guilian; Lee, Richard; Ropelewski, Philip; Imanishi, Yoshikazu

    2016-03-01

    The purpose of this study was to obtain an Usher syndrome type III mouse model with retinal phenotype. Speed congenic method was used to obtain Clrn1 exon 1 knockout (Clrn1-/-) and Clrn1N48K knockin (Clrn1N48K/N48K) mice under A/J background. To study the retinal functions of these mice, we measured scotopic and photopic ERG responses. To observe if there are any structural abnormalities, we conducted light and transmission electron microscopy of fixed retinal specimens. In 3-month-old Clrn1-/- mice, scotopic b-wave amplitude was reduced by more than 25% at the light intensities from -2.2 to 0.38 log cd·s/m2, but scotopic a-wave amplitudes were comparable to those of age-matched wild type mice at all the light intensities tested. In 9-month-old Clrn1-/- mice, scotopic b-wave amplitudes were further reduced by more than 35%, and scotopic a-wave amplitude also showed a small decline as compared with wild type mice. Photopic ERG responses were comparable between Clrn1-/- and wild type mice. Those electrophysiological defects were not associated with a loss of rods. In Clrn1N48K/N48K mice, both a- and b-wave amplitudes were not discernable from those of wild type mice aged up to 10 months. Mutations that are Clrn1-/- biallelic cause visual defects when placed under A/J background. The absence of apparent rod degeneration suggests that the observed phenotype is due to functional defects, and not due to loss of rods. Biallelic Clrn1N48K/N48K mutations did not cause discernible visual defects, suggesting that Clrn1- allele is more severely dysfunctional than ClrnN48K allele.

  18. Probing evolutionary population synthesis models in the near infrared with early-type galaxies

    Science.gov (United States)

    Dahmer-Hahn, Luis Gabriel; Riffel, Rogério; Rodríguez-Ardila, Alberto; Martins, Lucimara P.; Kehrig, Carolina; Heckman, Timothy M.; Pastoriza, Miriani G.; Dametto, Natacha Z.

    2018-06-01

    We performed a near-infrared (NIR; ˜1.0 -2.4 μm) stellar population study in a sample of early-type galaxies. The synthesis was performed using five different evolutionary population synthesis libraries of models. Our main results can be summarized as follows: low-spectral-resolution libraries are not able to produce reliable results when applied to the NIR alone, with each library finding a different dominant population. The two newest higher resolution models, on the other hand, perform considerably better, finding consistent results to each other and to literature values. We also found that optical results are consistent with each other even for lower resolution models. We also compared optical and NIR results and found out that lower resolution models tend to disagree in the optical and in the NIR, with higher fraction of young populations in the NIR and dust extinction ˜1 mag higher than optical values. For higher resolution models, optical and NIR results tend to agree much better, suggesting that a higher spectral resolution is fundamental to improve the quality of the results.

  19. One-dimensional Turbulence Models of Type I X-ray Bursts

    Energy Technology Data Exchange (ETDEWEB)

    Hou, Chen [Univ. of Minnesota, Minneapolis, MN (United States)

    2016-01-06

    Type I X-ray bursts are caused by thermonuclear explosions occurring on the surface of an accreting neutron star in a binary star system. Observations and simulations of these phenomena are of great importance for understanding the fundamental properties of neutron stars and dense matter because the equation of state for cold dense matter can be constrained by the mass-radius relationship of neutron stars. During the bursts, turbulence plays a key role in mixing the fuels and driving the unstable nuclear burning process. This dissertation presents one-dimensional models of photospheric radius expansion bursts with a new approach to simulate turbulent advection. Compared with the traditional mixing length theory, the one-dimensional turbulence (ODT) model represents turbulent motions by a sequence of maps that are generated according to a stochastic process. The light curves I obtained with the ODT models are in good agreement with those of the KEPLER model in which the mixing length theory and various diffusive processes are applied. The abundance comparison, however, indicates that the differences in turbulent regions and turbulent diffusivities result in more 12C survival during the bursts in the ODT models, which can make a difference in the superbursts phenomena triggered by unstable carbon burning.

  20. One-dimensional Turbulence Models of Type I X-ray Bursts

    International Nuclear Information System (INIS)

    Hou, Chen

    2016-01-01

    Type I X-ray bursts are caused by thermonuclear explosions occurring on the surface of an accreting neutron star in a binary star system. Observations and simulations of these phenomena are of great importance for understanding the fundamental properties of neutron stars and dense matter because the equation of state for cold dense matter can be constrained by the mass-radius relationship of neutron stars. During the bursts, turbulence plays a key role in mixing the fuels and driving the unstable nuclear burning process. This dissertation presents one-dimensional models of photospheric radius expansion bursts with a new approach to simulate turbulent advection. Compared with the traditional mixing length theory, the one-dimensional turbulence (ODT) model represents turbulent motions by a sequence of maps that are generated according to a stochastic process. The light curves I obtained with the ODT models are in good agreement with those of the KEPLER model in which the mixing length theory and various diffusive processes are applied. The abundance comparison, however, indicates that the differences in turbulent regions and turbulent diffusivities result in more 12 C survival during the bursts in the ODT models, which can make a difference in the superbursts phenomena triggered by unstable carbon burning.

  1. Evaluation of INL Supplied MOOSE/OSPREY Model: Modeling Water Adsorption on Type 3A Molecular Sieve

    Energy Technology Data Exchange (ETDEWEB)

    Pompilio, L. M. [Syracuse University; DePaoli, D. W. [ORNL; Spencer, B. B. [ORNL

    2014-08-29

    The purpose of this study was to evaluate Idaho National Lab’s Multiphysics Object-Oriented Simulation Environment (MOOSE) software in modeling the adsorption of water onto type 3A molecular sieve (3AMS). MOOSE can be thought-of as a computing framework within which applications modeling specific coupled-phenomena can be developed and run. The application titled Off-gas SeParation and REcoverY (OSPREY) has been developed to model gas sorption in packed columns. The sorbate breakthrough curve calculated by MOOSE/OSPREY was compared to results previously obtained in the deep bed hydration tests conducted at Oak Ridge National Laboratory. The coding framework permits selection of various options, when they exist, for modeling a process. For example, the OSPREY module includes options to model the adsorption equilibrium with a Langmuir model or a generalized statistical thermodynamic adsorption (GSTA) model. The vapor solid equilibria and the operating conditions of the process (e.g., gas phase concentration) are required to calculate the concentration gradient driving the mass transfer between phases. Both the Langmuir and GSTA models were tested in this evaluation. Input variables were either known from experimental conditions, or were available (e.g., density) or were estimated (e.g., thermal conductivity of sorbent) from the literature. Variables were considered independent of time, i.e., rather than having a mass transfer coefficient that varied with time or position in the bed, the parameter was set to remain constant. The calculated results did not coincide with data from laboratory tests. The model accurately estimated the number of bed volumes processed for the given operating parameters, but breakthrough times were not accurately predicted, varying 50% or more from the data. The shape of the breakthrough curves also differed from the experimental data, indicating a much wider sorption band. Model modifications are needed to improve its utility and

  2. A new type of disconnectedness problem in a field-theory model of the NNπ system

    International Nuclear Information System (INIS)

    Stelbovics, A.T.; Stingl, M.

    1978-01-01

    When treated as an effective three-body problem in the framework of a simple field-theory model, the NNπ system acquires, in addition to the disconnected subsystem interactions usually considered, a new type of disconnected driving term, possible only for non-conserved particles such as the π. These terms pose a disconnectedness problem more intricate than that solved by Faddeev's equations or their known modifications for connected three-body forces. The solution of this problem in terms of a set of connected-kernel integral equations is presented. (Auth.)

  3. Analytic approximations to nonlinear boundary value problems modeling beam-type nano-electromechanical systems

    Energy Technology Data Exchange (ETDEWEB)

    Zou, Li [Dalian Univ. of Technology, Dalian City (China). State Key Lab. of Structural Analysis for Industrial Equipment; Liang, Songxin; Li, Yawei [Dalian Univ. of Technology, Dalian City (China). School of Mathematical Sciences; Jeffrey, David J. [Univ. of Western Ontario, London (Canada). Dept. of Applied Mathematics

    2017-06-01

    Nonlinear boundary value problems arise frequently in physical and mechanical sciences. An effective analytic approach with two parameters is first proposed for solving nonlinear boundary value problems. It is demonstrated that solutions given by the two-parameter method are more accurate than solutions given by the Adomian decomposition method (ADM). It is further demonstrated that solutions given by the ADM can also be recovered from the solutions given by the two-parameter method. The effectiveness of this method is demonstrated by solving some nonlinear boundary value problems modeling beam-type nano-electromechanical systems.

  4. Asteroseismology of solar-type stars with Kepler: II. Stellar modeling

    DEFF Research Database (Denmark)

    Metcalfe , T.S.; Karoff, Christoffer

    2010-01-01

    Observations from the Kepler satellite were recently published for three bright G-type stars, which were monitored during the first 33.5 days of science operations. One of these stars, KIC 11026764, exhibits a characteristic pattern of oscillation frequencies suggesting that the star has evolved...... significantly. We have derived initial estimates of the properties of KIC 11026764 from the oscillation frequencies observed by Kepler, combined with ground-based spectroscopic data. We present preliminary results from detailed modeling of this star, employing a variety of independent codes and analyses...

  5. Traveling waves in a diffusive predator-prey model with holling type-III functional response

    International Nuclear Information System (INIS)

    Li Wantong; Wu Shiliang

    2008-01-01

    We establish the existence of traveling wave solutions and small amplitude traveling wave train solutions for a reaction-diffusion system based on a predator-prey model with Holling type-III functional response. The analysis is in the three-dimensional phase space of the nonlinear ordinary differential equation system given by the diffusive predator-prey system in the traveling wave variable. The methods used to prove the results are the shooting argument, invariant manifold theory and the Hopf bifurcation theorem

  6. Toxicity studies of six types of carbon nanoparticles in a chicken-embryo model

    DEFF Research Database (Denmark)

    Kurantowicz, Natalia; Sawosz, Ewa; Halik, Gabriela

    2017-01-01

    -cell morphology, blood serum biochemical parameters, and oxidative damage in the liver did not differ among the groups. These results indicate that CNPs can remain in blood circulation without any major side effects, suggesting their potential applicability as vehicles for drug delivery or active compounds per se......In the present study, the toxicity of six different types of carbon nanoparticles (CNPs) was investigated using a chicken-embryo model. Fertilized chicken eggs were divided into the following treatment groups: placebo, diamond NPs, graphite NPs, pristine graphene, small graphene oxide, large...

  7. Modeling the differentiation of A- and C-type baroreceptor firing patterns

    DEFF Research Database (Denmark)

    Sturdy, Jacob; Ottesen, Johnny T.; Olufsen, Mette

    2017-01-01

    The baroreceptor neurons serve as the primary transducers of blood pressure for the autonomic nervous system and are thus critical in enabling the body to respond effectively to changes in blood pressure. These neurons can be separated into two types (A and C) based on the myelination...... of their axons and their distinct firing patterns elicited in response to specific pressure stimuli. This study has developed a comprehensive model of the afferent baroreceptor discharge built on physiological knowledge of arterial wall mechanics, firing rate responses to controlled pressure stimuli, and ion...

  8. Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes

    OpenAIRE

    Yokoi, Norihide; Beppu, Masayuki; Yoshida, Eri; Hoshikawa, Ritsuko; Hidaka, Shihomi; Matsubara, Toshiya; Shinohara, Masami; Irino, Yasuhiro; Hatano, Naoya; Seino, Susumu

    2015-01-01

    Biomarkers for the development of type 2 diabetes (T2D) are useful for prediction and intervention of the disease at earlier stages. In this study, we performed a longitudinal study of changes in metabolites using an animal model of T2D, the spontaneously diabetic Torii (SDT) rat. Fasting plasma samples of SDT and control Sprague-Dawley (SD) rats were collected from 6 to 24 weeks of age, and subjected to gas chromatography–mass spectrometry-based metabolome analysis. Fifty-nine hydrophilic me...

  9. Understanding and modeling Förster-type resonance energy transfer (FRET)

    CERN Document Server

    Hernández Martínez, Pedro Ludwig; Demir, Hilmi Volkan

    2017-01-01

    This Brief presents a complete study of the generalized theory of Förster-type energy transfer in nanostructures with mixed dimensionality. Here the aim is to obtain a generalized theory of FRET including a comprehensive set of analytical equations for all combinations and configurations of nanostructures and deriving generic expressions for the dimensionality involved. In this brief, the modification of FRET mechanism with respect to the nanostructure serving as the donor vs. the acceptor will be included, focusing on the rate’s distance dependency and the role of the effective dielectric function in FRET, which will be a unique, useful source for those who study and model FRET.

  10. Studying the highly bent spectra of FR II-type radio galaxies with the KDA EXT model

    Science.gov (United States)

    Kuligowska, Elżbieta

    2018-04-01

    Context. The Kaiser, Dennett-Thorpe & Alexander (KDA, 1997, MNRAS, 292, 723) EXT model, that is, the extension of the KDA model of Fanaroff & Riley (FR) II-type source evolution, is applied and confronted with the observational data for selected FR II-type radio sources with significantly aged radio spectra. Aim. A sample of FR II-type radio galaxies with radio spectra strongly bent at their highest frequencies is used for testing the usefulness of the KDA EXT model. Methods: The dynamical evolution of FR II-type sources predicted with the KDA EXT model is briefly presented and discussed. The results are then compared to the ones obtained with the classical KDA approach, assuming the source's continuous injection and self-similarity. Results: The results and corresponding diagrams obtained for the eight sample sources indicate that the KDA EXT model predicts the observed radio spectra significantly better than the best spectral fit provided by the original KDA model.

  11. Quantification of age-related changes in the structure model type and trabecular thickness of human tibial cancellous

    DEFF Research Database (Denmark)

    Ding, Ming; Hvid, I

    2000-01-01

    Structure model type and trabecular thickness are important characteristics in describing cancellous bone architecture. It has been qualitatively observed that a radical change of trabeculae from plate-like to rod-like occurs in aging, bone remodeling, and osteoporosis. Thickness of trabeculae has...... traditionally been measured using model-based histomorphometric methods on two-dimensional (2-D) sections. However, no quantitative study has been published based on three-dimensional (3-D) methods on the age-related changes in structure model type and trabecular thickness for human peripheral (tibial......, structure model type and trabecular thickness were quantified by means of novel 3-D methods. Structure model type was assessed by calculating the structure model index (SMI). The SMI was quantified based on a differential analysis of the triangulated bone surface of a structure. This technique allows...

  12. THE DETONATION MECHANISM OF THE PULSATIONALLY ASSISTED GRAVITATIONALLY CONFINED DETONATION MODEL OF Type Ia SUPERNOVAE

    Energy Technology Data Exchange (ETDEWEB)

    Jordan, G. C. IV; Graziani, C.; Weide, K.; Norris, J.; Hudson, R.; Lamb, D. Q. [Flash Center for Computational Science, University of Chicago, Chicago, IL 60637 (United States); Fisher, R. T. [Department of Physics, University of Massachusetts Dartmouth, 285 Old Westport Road, North Dartmouth, MA 02740 (United States); Townsley, D. M. [Department of Physics and Astronomy, University of Alabama, Tuscaloosa, AL 35487 (United States); Meakin, C. [Steward Observatory, University of Arizona, Tucson, AZ 85721 (United States); Reid, L. B. [NTEC Environmental Technology, Subiaco WA 6008 (Australia)

    2012-11-01

    We describe the detonation mechanism composing the 'pulsationally assisted' gravitationally confined detonation (GCD) model of Type Ia supernovae. This model is analogous to the previous GCD model reported in Jordan et al.; however, the chosen initial conditions produce a substantively different detonation mechanism, resulting from a larger energy release during the deflagration phase. The resulting final kinetic energy and {sup 56}Ni yields conform better to observational values than is the case for the 'classical' GCD models. In the present class of models, the ignition of a deflagration phase leads to a rising, burning plume of ash. The ash breaks out of the surface of the white dwarf, flows laterally around the star, and converges on the collision region at the antipodal point from where it broke out. The amount of energy released during the deflagration phase is enough to cause the star to rapidly expand, so that when the ash reaches the antipodal point, the surface density is too low to initiate a detonation. Instead, as the ash flows into the collision region (while mixing with surface fuel), the star reaches its maximally expanded state and then contracts. The stellar contraction acts to increase the density of the star, including the density in the collision region. This both raises the temperature and density of the fuel-ash mixture in the collision region and ultimately leads to thermodynamic conditions that are necessary for the Zel'dovich gradient mechanism to produce a detonation. We demonstrate feasibility of this scenario with three three-dimensional (3D), full star simulations of this model using the FLASH code. We characterized the simulations by the energy released during the deflagration phase, which ranged from 38% to 78% of the white dwarf's binding energy. We show that the necessary conditions for detonation are achieved in all three of the models.

  13. Survey of non-linear hydrodynamic models of type-II Cepheids

    Science.gov (United States)

    Smolec, R.

    2016-03-01

    We present a grid of non-linear convective type-II Cepheid models. The dense model grids are computed for 0.6 M⊙ and a range of metallicities ([Fe/H] = -2.0, -1.5, -1.0), and for 0.8 M⊙ ([Fe/H] = -1.5). Two sets of convective parameters are considered. The models cover the full temperature extent of the classical instability strip, but are limited in luminosity; for the most luminous models, violent pulsation leads to the decoupling of the outermost model shell. Hence, our survey reaches only the shortest period RV Tau domain. In the Hertzsprung-Russell diagram, we detect two domains in which period-doubled pulsation is possible. The first extends through the BL Her domain and low-luminosity W Vir domain (pulsation periods ˜2-6.5 d). The second domain extends at higher luminosities (W Vir domain; periods >9.5 d). Some models within these domains display period-4 pulsation. We also detect very narrow domains (˜10 K wide) in which modulation of pulsation is possible. Another interesting phenomenon we detect is double-mode pulsation in the fundamental mode and in the fourth radial overtone. Fourth overtone is a surface mode, trapped in the outer model layers. Single-mode pulsation in the fourth overtone is also possible on the hot side of the classical instability strip. The origin of the above phenomena is discussed. In particular, the role of resonances in driving different pulsation dynamics as well as in shaping the morphology of the radius variation curves is analysed.

  14. Simple Prediction of Type 2 Diabetes Mellitus via Decision Tree Modeling

    Directory of Open Access Journals (Sweden)

    Mehrab Sayadi

    2017-06-01

    Full Text Available Background: Type 2 Diabetes Mellitus (T2DM is one of the most important risk factors in cardiovascular disorders considered as a common clinical and public health problem. Early diagnosis can reduce the burden of the disease. Decision tree, as an advanced data mining method, can be used as a reliable tool to predict T2DM. Objectives: This study aimed to present a simple model for predicting T2DM using decision tree modeling. Materials and Methods: This analytical model-based study used a part of the cohort data obtained from a database in Healthy Heart House of Shiraz, Iran. The data included routine information, such as age, gender, Body Mass Index (BMI, family history of diabetes, and systolic and diastolic blood pressure, which were obtained from the individuals referred for gathering baseline data in Shiraz cohort study from 2014 to 2015. Diabetes diagnosis was used as binary datum. Decision tree technique and J48 algorithm were applied using the WEKA software (version 3.7.5, New Zealand. Additionally, Receiver Operator Characteristic (ROC curve and Area Under Curve (AUC were used for checking the goodness of fit. Results: The age of the 11302 cases obtained after data preparation ranged from 18 to 89 years with the mean age of 48.1 ± 11.4 years. Additionally, 51.1% of the cases were male. In the tree structure, blood pressure and age were placed where most information was gained. In our model, however, gender was not important and was placed on the final branch of the tree. Total precision and AUC were 87% and 89%, respectively. This indicated that the model had good accuracy for distinguishing patients from normal individuals. Conclusions: The results showed that T2DM could be predicted via decision tree model without laboratory tests. Thus, this model can be used in pre-clinical and public health screening programs.

  15. A Model Based Approach to Sample Size Estimation in Recent Onset Type 1 Diabetes

    Science.gov (United States)

    Bundy, Brian; Krischer, Jeffrey P.

    2016-01-01

    The area under the curve C-peptide following a 2-hour mixed meal tolerance test from 481 individuals enrolled on 5 prior TrialNet studies of recent onset type 1 diabetes from baseline to 12 months after enrollment were modelled to produce estimates of its rate of loss and variance. Age at diagnosis and baseline C-peptide were found to be significant predictors and adjusting for these in an ANCOVA resulted in estimates with lower variance. Using these results as planning parameters for new studies results in a nearly 50% reduction in the target sample size. The modelling also produces an expected C-peptide that can be used in Observed vs. Expected calculations to estimate the presumption of benefit in ongoing trials. PMID:26991448

  16. A model-based approach to sample size estimation in recent onset type 1 diabetes.

    Science.gov (United States)

    Bundy, Brian N; Krischer, Jeffrey P

    2016-11-01

    The area under the curve C-peptide following a 2-h mixed meal tolerance test from 498 individuals enrolled on five prior TrialNet studies of recent onset type 1 diabetes from baseline to 12 months after enrolment were modelled to produce estimates of its rate of loss and variance. Age at diagnosis and baseline C-peptide were found to be significant predictors, and adjusting for these in an ANCOVA resulted in estimates with lower variance. Using these results as planning parameters for new studies results in a nearly 50% reduction in the target sample size. The modelling also produces an expected C-peptide that can be used in observed versus expected calculations to estimate the presumption of benefit in ongoing trials. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  17. Isotropization in Bianchi type-I cosmological model with fermions and bosons interacting via Yukawa potential

    International Nuclear Information System (INIS)

    Ribas, M O; Samojeden, L L; Devecchi, F P; Kremer, G M

    2015-01-01

    In this work we investigate a model for the early Universe in a Bianchi type-I metric, where the sources of the gravitational field are a fermionic and a bosonic field, interacting through a Yukawa potential, following the standard model of elementary particles. It is shown that the fermionic field has a negative pressure, while the boson has a small positive pressure. The fermionic field is the responsible for an accelerated regime at early times, but since the total pressure tends to zero for large times, a transition to a decelerated regime occurs. Here the Yukawa potential answers for the duration of the accelerated regime, since by decreasing the value of its coupling constant the transition accelerated–decelerated occurs in later times. The isotropization which occurs for late times is due to the presence of the fermionic field as one of the sources of the gravitational field. (paper)

  18. Geochemical modelling of Na-SO4 type groundwater at Palmottu using a mass balance approach

    International Nuclear Information System (INIS)

    Pitkaenen, P.

    1993-01-01

    The mass balance chemical modelling technique has been applied to the groundwaters at the Palmottu analogue study site (in southwestern Finland) for radioactive waste disposal. The geochemical modelling concentrates on the evolution of Na-SO 4 type groundwater, which is spatially connected to the uranium mineralization. The results calculated along an assumed flow path are consistent with available field data and thermodynamic constraints. The results show that essential production of sulphides is unrealistic in the prevailing conditions. The increasing concentrations of Na, SO 4 and Cl along the evolution trend seem to have the same source and they could originate mainly from the leakage of fluid inclusions. Some mixing of relict sea water is also possible

  19. An economic order quantity model with nonlinear holding cost, partial backlogging and ramp-type demand

    Science.gov (United States)

    San-José, Luis A.; Sicilia, Joaquín; González-de-la-Rosa, Manuel; Febles-Acosta, Jaime

    2018-07-01

    In this article, a deterministic inventory model with a ramp-type demand depending on price and time is developed. The cumulative holding cost is assumed to be a nonlinear function of time. Shortages are allowed and are partially backlogged. Thus, the fraction of backlogged demand depends on the waiting time and on the stock-out period. The aim is to maximize the total profit per unit time. To do this, a procedure that determines the economic lot size, the optimal inventory cycle and the maximum profit is presented. The inventory system studied here extends diverse inventory models proposed in the literature. Finally, some numerical examples are provided to illustrate the theoretical results previously propounded.

  20. Effect of including decay chains on predictions of equilibrium-type terrestrial food chain models

    International Nuclear Information System (INIS)

    Kirchner, G.

    1990-01-01

    Equilibrium-type food chain models are commonly used for assessing the radiological impact to man from environmental releases of radionuclides. Usually these do not take into account build-up of radioactive decay products during environmental transport. This may be a potential source of underprediction. For estimating consequences of this simplification, the equations of an internationally recognised terrestrial food chain model have been extended to include decay chains of variable length. Example calculations show that for releases from light water reactors as expected both during routine operation and in the case of severe accidents, the build-up of decay products during environmental transport is generally of minor importance. However, a considerable number of radionuclides of potential radiological significance have been identified which show marked contributions of decay products to calculated contamination of human food and resulting radiation dose rates. (author)