Topics in industrial mathematics

International Nuclear Information System (INIS)

Vatsya, S.R.

1992-01-01

Mathematical methods are widely used to solve practical problems arising in modern industry. This article outlines some of the topics relevant to AECL programmes. This covers the applications of transmission and neutron transport tomography to determine density distributions in rocks and two phase flow situations. Another example covered is the use of variational methods to solve the problems of aerosol migration and control theory. (author). 7 refs

Preparation of a continuative brochure as supplement to the evaluation hand-out for the assessment of study results; Erstellung einer weiterfuehrenden Broschuere als Ergaenzung zur Handreichung der Beurteilung von Studienergebnissen

Energy Technology Data Exchange (ETDEWEB)

Wilhelmy, S.; Gollnick, F.; Driessen, S.; Schmidt, M.; Gross, D.

2015-08-15

In 2013 the Federal Office for Radiation Protection gave the responsibility to the Department of History, Philosophy and Ethics of Medicine (Institut GTE Med) in Aachen for the project ''Creating a practical hand-out for the assessment of study results for employees of local governments'' (FM 8855). The manual serves as a practical way for the qualitative evaluation of texts for persons who deal with the topics Mobile Communication and Health (for example communities or government agencies) in their profession. The main objective of the manual is to aid users in performing a faster and more efficient evaluation of texts by answering the containing questions. This approach is purely functional and precludes the placement of deeper information. At this point the new project FM 8862 started by ''Creating a continuative brochure in addition to the hand-out for the assessment of study results''. It continued the previous project FM 8855 to further develop the information which was up to this point purely functional. The brochure presents the issues in an overall context and provides valuable background knowledge. As a result, possible users get in a more casual and clear manner a deeper understanding of the evaluating of texts. It should be possible for a user to better evaluate texts and by obtaining arguments, thus being better prepared to engage with interested Laymen in an objective discussion. The brochure was submitted together with the existing manual for a practical test, which was attended by 21 target group-specific subjects. The study tested in detail the intelligibility, clarity, applicability, and the support of the brochure. The feedback of the test participants were then used as basis for the final optimization of the brochure. Project participants belong to the Department of History, Philosophy and Ethics of Medicine and the Research Center for Bioelectromagnetic Interaction of the RWTH Aachen University (femu).

Human-competitive automatic topic indexing

CERN Document Server

Medelyan, Olena

2009-01-01

Topic indexing is the task of identifying the main topics covered by a document. These are useful for many purposes: as subject headings in libraries, as keywords in academic publications and as tags on the web. Knowing a document’s topics helps people judge its relevance quickly. However, assigning topics manually is labor intensive. This thesis shows how to generate them automatically in a way that competes with human performance. Three kinds of indexing are investigated: term assignment, a task commonly performed by librarians, who select topics from a controlled vocabulary; tagging, a popular activity of web users, who choose topics freely; and a new method of keyphrase extraction, where topics are equated to Wikipedia article names. A general two-stage algorithm is introduced that first selects candidate topics and then ranks them by significance based on their properties. These properties draw on statistical, semantic, domain-specific and encyclopedic knowledge. They are combined using a machine learn...

Topics in lightwave transmission systems

CERN Document Server

Li, Tingye

1991-01-01

Topics in Lightwave Transmission Systems is a second volume of a treatise on optical fiber communications that is devoted to the science, engineering, and application of information transmission via optical fibers. The first volume, published in 1985, dealt exclusively with fiber fabrication. The present volume contains topics that pertain to subsystems and systems. The book contains five chapters and begins with discussions of transmitters and receivers, which are basic to systems now operating in the field. Subsequent chapters cover topics relating to coherent systems: frequency and phase m

Lecture Notes on Topics in Accelerator Physics

International Nuclear Information System (INIS)

Chao, Alex W.

2002-01-01

These are lecture notes that cover a selection of topics, some of them under current research, in accelerator physics. I try to derive the results from first principles, although the students are assumed to have an introductory knowledge of the basics. The topics covered are: (1) Panofsky-Wenzel and Planar Wake Theorems; (2) Echo Effect; (3) Crystalline Beam; (4) Fast Ion Instability; (5) Lawson-Woodward Theorem and Laser Acceleration in Free Space; (6) Spin Dynamics and Siberian Snakes; (7) Symplectic Approximation of Maps; (8) Truncated Power Series Algebra; and (9) Lie Algebra Technique for nonlinear Dynamics. The purpose of these lectures is not to elaborate, but to prepare the students so that they can do their own research. Each topic can be read independently of the others

Lecture Notes on Topics in Accelerator Physics

Energy Technology Data Exchange (ETDEWEB)

Chao, Alex W.

2002-11-15

These are lecture notes that cover a selection of topics, some of them under current research, in accelerator physics. I try to derive the results from first principles, although the students are assumed to have an introductory knowledge of the basics. The topics covered are: (1) Panofsky-Wenzel and Planar Wake Theorems; (2) Echo Effect; (3) Crystalline Beam; (4) Fast Ion Instability; (5) Lawson-Woodward Theorem and Laser Acceleration in Free Space; (6) Spin Dynamics and Siberian Snakes; (7) Symplectic Approximation of Maps; (8) Truncated Power Series Algebra; and (9) Lie Algebra Technique for nonlinear Dynamics. The purpose of these lectures is not to elaborate, but to prepare the students so that they can do their own research. Each topic can be read independently of the others.

Topics of Bioengineering in Wikipedia

Directory of Open Access Journals (Sweden)

Vassia Atanassova

2009-10-01

Full Text Available The present report aims to give a snapshot of how topics from the field of bioengineering (bioinformatics, bioprocess systems, biomedical engineering, biotechnology, etc. are currently covered in the free electronic encyclopedia Wikipedia. It also offers insights and information about what Wikipedia is, how it functions, how and when to cite Wikipedian articles, if necessary. Several external wikis, devoted to topics of bioengineering, are also listed and reviewed.

2011 annual meeting on nuclear technology. Pt. 4. Topical sessions

International Nuclear Information System (INIS)

Schoenfelder, Christian; Dams, Wolfgang

2011-01-01

Summary report on the Topical Session of the Annual Conference on Nuclear Technology held in Berlin, 17 to 19 May 2011: - Nuclear Competence in Germany and Europe. The Topical Session: - Sodium Cooled Fast Reactors -- will be covered in a report in a further issue of atw. The reports on the Topical Sessions: - CFD-Simulations for Safety Relevant Tasks; and - Final Disposal: From Scientific Basis to Application; - Characteristics of a High Reliability Organization (HRO) Considering Experience Gained from Events at Nuclear Power Stations -- have been covered in atw 7, 8/9, and 10 (2011). (orig.)

Key Topics in Sports Medicine

OpenAIRE

2006-01-01

Key Topics in Sports Medicine is a single quick reference source for sports and exercise medicine. It presents the essential information from across relevant topic areas, and includes both the core and emerging issues in this rapidly developing field. It covers: 1) Sports injuries, rehabilitation and injury prevention, 2) Exercise physiology, fitness testing and training, 3) Drugs in sport, 4) Exercise and health promotion, 5) Sport and exercise for special and clinical populations, 6) The ps...

Section 608 Technician Certification Test Topics

Science.gov (United States)

Identifies some of the topics covered on Section 608 Technician Certification tests such as ozone depletion, the Clean Air Act and Montreal Protocol, Substitute Refrigerants and oils, Refrigeration and Recovery Techniques.

Treatment Duration of Topics in Senior Secondary School Core ...

African Journals Online (AJOL)

kofimereku

years to better equip the students for university education (Daily Graphic of. September 15th 1998). .... five items similar to those in the SS Mathematics Book 3, and covered all the sub-topics of the topic ..... Soviet Union. United States. 181. 188.

Topics in current aerosol research

CERN Document Server

Hidy, G M

1971-01-01

Topics in Current Aerosol Research deals with the fundamental aspects of aerosol science, with emphasis on experiment and theory describing highly dispersed aerosols (HDAs) as well as the dynamics of charged suspensions. Topics covered range from the basic properties of HDAs to their formation and methods of generation; sources of electric charges; interactions between fluid and aerosol particles; and one-dimensional motion of charged cloud of particles. This volume is comprised of 13 chapters and begins with an introduction to the basic properties of HDAs, followed by a discussion on the form

Topics in supergravity and string theory

International Nuclear Information System (INIS)

Eastaugh, A.G.

1987-01-01

The first topic covered in this dissertation concerns the harmonic expansion technique and its application to the dimensional compactification of higher dimensional supergravity. A simple example is given to explain the method and then the method is applied to the problem of obtaining the mass spectrum of the squashed seven-sphere compactification of eleven dimensional supergravity. The second topic concerns the application of Fujikawa's method of anomaly calculation to the calculation of the critical dimension of various string models. The third topic is a study and explicit calculation of the Fock space representation of the vertex in Witten's formulation of the interacting open bosonic string field theory

Covering of the electric power service

International Nuclear Information System (INIS)

Unidad de Planeacion Minero Energetica, UPME

2000-01-01

In this article it is sought to deepen more in the topic of the covering of the electric power service, especially in the related with the mechanisms that could facilitate their amplification. In the new market outline, in the one that the participation of the agents is encouraged in all the activities of the chain of services in which the state is not direct lender of the same one, it is confused the form like a covering will be achieved that is of agreement with the goals that intend in the national plan of development and in the sub sectorial plans. Although the rules of the market one comes consolidating, the process of linking of the private capital, especially in the distribution activity, it evidences the importance of to settle down and to define responsibilities and explicit mechanisms in the topic of expansion of the covering. A first interpretation of the ruled indicates the obligation of the state of extending the covering to 100% and of assuming the projects that don't undertake the matters. This would be the reading from the traditional mentality. However, the regulation of you public services of electricity don't demand a total covering, but rather it covers to the users that have the capacity to assume, with their own resources, the efficient costs of benefit. The service will also be lent to residential users that don't have payment capacity, when there are contribution resources or fiscal resources for subsidiary

SETI: A good introductory physics topic

Science.gov (United States)

Hobson, Art

1997-04-01

If America is to achieve the science literacy that is essential to industrialized democracy, all students must study such topics as scientific methodology, pseudoscience, ozone depletion, and global warming. My large-enrollment liberal-arts physics course covers the great principles of physics along with several such philosophical and societal topics. It is easy to include the interdisciplinary context of physics in courses for non-scientists, because these courses are flexible, conceptual, and taught to students whose interests span a broad range. Students find these topics relevant and fascinating, leading to large enrollments by non-scientists even in courses labeled ''physics.'' I will discuss my approach to teaching the search for extra-terrestrial intelligence (SETI), a topic with lots of good physics and with connections to scientific methodology and pseudoscience. A textbook for this kind of course has been published, Physics: Concepts and Connections (Prentice-Hall, 1995).

Dressings and topical agents for surgical wounds healing by secondary intention

NARCIS (Netherlands)

Vermeulen, H.; Ubbink, D.; Goossens, A.; de Vos, R.; Legemate, D.

2004-01-01

BACKGROUND: Many different wound dressings and topical applications are used to cover surgical wounds healing by secondary intention. It is not known whether these dressings heal wounds at different rates. OBJECTIVES: To assess the effectiveness of dressings and topical agents on surgical wounds

Conference on Stochastic Analysis and Related Topics

CERN Document Server

Peterson, Jonathon

2017-01-01

The articles in this collection are a sampling of some of the research presented during the conference “Stochastic Analysis and Related Topics”, held in May of 2015 at Purdue University in honor of the 60th birthday of Rodrigo Bañuelos. A wide variety of topics in probability theory is covered in these proceedings, including heat kernel estimates, Malliavin calculus, rough paths differential equations, Lévy processes, Brownian motion on manifolds, and spin glasses, among other topics.

Selected topics from classical bacterial genetics.

Science.gov (United States)

Raleigh, Elisabeth A; Elbing, Karen; Brent, Roger

2002-08-01

Current cloning technology exploits many facts learned from classical bacterial genetics. This unit covers those that are critical to understanding the techniques described in this book. Topics include antibiotics, the LAC operon, the F factor, nonsense suppressors, genetic markers, genotype and phenotype, DNA restriction, modification and methylation and recombination.

Hot Topics/New Initiatives | Drinking Water in New England ...

Science.gov (United States)

2017-07-06

Information on Drinking Water in New England. Major Topics covered include: Conservation, Private Wells, Preventing Contamination, Drinking Water Sources, Consumer Confidence Reports, and Drinking Water Awards.

Applied atomic and collision physics special topics

CERN Document Server

Massey, H S W; Bederson, Benjamin

1982-01-01

Applied Atomic Collision Physics, Volume 5: Special Topics deals with topics on applications of atomic collisions that were not covered in the first four volumes of the treatise. The book opens with a chapter on ultrasensitive chemical detectors. This is followed by separate chapters on lighting, magnetohydrodynamic electrical power generation, gas breakdown and high voltage insulating gases, thermionic energy converters, and charged particle detectors. Subsequent chapters deal with the operation of multiwire drift and proportional chambers and streamer chambers and their use in high energy p

Topics in current aerosol research (part2)

CERN Document Server

Hidy, G M

1972-01-01

Topics in Current Aerosol Research, Part 2 contains some selected articles in the field of aerosol study. The chosen topics deal extensively with the theory of diffusiophoresis and thermophoresis. Also covered in the book is the mathematical treatment of integrodifferential equations originating from the theory of aerosol coagulation. The book is the third volume of the series entitled International Reviews in Aerosol Physics and Chemistry. The text offers significant understanding of the methods employed to develop a theory for thermophoretic and diffusiophoretic forces acting on spheres in t

Specialists' meeting on fast reactor cover gas purification

International Nuclear Information System (INIS)

1987-01-01

The tentative agenda was adopted by the participants without comment and was followed throughout the meeting. The following topics were discussed at the subsequent sessions of the meeting on 'Fast Reactor Cover Gas Purification': National Position Papers; Impurities: Sources and Measurement; Cover Gas Purification Techniques; Sodium Aerosol Trapping; Radiological Considerations. Based on the papers presented and the discussions following, session summaries and conclusions were prepared and are included in this report

Specialists' meeting on fast reactor cover gas purification

Energy Technology Data Exchange (ETDEWEB)

NONE

1987-07-01

The tentative agenda was adopted by the participants without comment and was followed throughout the meeting. The following topics were discussed at the subsequent sessions of the meeting on 'Fast Reactor Cover Gas Purification': National Position Papers; Impurities: Sources and Measurement; Cover Gas Purification Techniques; Sodium Aerosol Trapping; Radiological Considerations. Based on the papers presented and the discussions following, session summaries and conclusions were prepared and are included in this report.

Topics to be covered in safety analysis reports for nuclear power plants with pressurized water reactors or boiling water reactors in the F.R.G

International Nuclear Information System (INIS)

Kohler, H.A.G.

1977-01-01

This manual aims at defining the standards to be used in Safety Analysis Reports for Nuclear Power Plants with Pressurized Water Reactors or Boiling Water Reactors in the Federal Republic of Germany. The topics to be covered are: Information about the site (geographic situation, settlement, industrial and military facilities, transport and communications, meteorological conditions, geological, hydrological and seismic conditions, radiological background), description of the power plant (building structures, safety vessel, reactor core, cooling system, ventilation systems, steam power plant, electrical facilities, systems for measurement and control), indication of operation (commissioning, operation, safety measures, radiation monitoring, organization), incident analysis (reactivity incidents, loss-of-coolant incidents, external impacts). (HP) [de

Topics in Bioethics: A Development of Student Perspectives

Directory of Open Access Journals (Sweden)

Keith A. Johnson

2014-10-01

Full Text Available Exposing students to current biotechnological and medical issues is eye-opening for many students in a way that is not always achieved through lecture-based learning. Lecture or investigative teaching styles provide a tremendous knowledge base for the students, but sometimes these teaching styles do not allow the student to fully develop, especially personal attitudes to issues in bioethics. Through online videos, Hollywood movies, guided readings and classroom discussions, students in this course are informed of some bioethical topics, encouraged to learn about other topics, and use this gained knowledge to develop personal positions regarding the value and/or risk of the issues. This course has been well-received by previous students as a favorite in terms of both topics covered and style.

Design review report, 241-S-102 cover plate review; TOPICAL

International Nuclear Information System (INIS)

ADAMS, M.R.

1998-01-01

The design for the cover plate and lead plate for shielding on 241-S-102 was reviewed on 10/21/98. All Review Comment Record comments were resolved to the satisfaction of the reviewers. Additional comments were taken during the meeting and were also resolved. A design calculation for the Radiological Design Review Screening was presented as criteria for the use of 1 inch lead plate. The review concluded that the use of 2 inch steel plate and 1 inch lead plate provided the required safety function required by HNF-SD-WM-810-001, 5.3.2.20, Basis for Interim Operation. The design was approved with the incorporated comments as recorded on RCR's and meeting minutes

Teaching Hiroshima: Thinking about the Unthinkable.

Science.gov (United States)

Dyke, Reg

1983-01-01

Describes the instructional materials used in a sophomore literature course to deal with the topic of possible nuclear destruction, including John Hersey's "Hiroshima"; photographs of Hiroshima and Nagasaki; Carl Sagan's "Cosmos"; and specially prepared handouts and worksheets. (LAL)

Modern topics in electron scattering

CERN Document Server

Frois, Bernard

1991-01-01

This book summarizes the considerable progress recently achieved in the understanding of nucleon and nuclear structure by using high energy electrons as a probe. A collection of papers discusses in detail the new frontiers of this field. Experimental and theoretical articles cover topics such as the structure of the nucleon, nucleon distributions, many-body correlations, non-nucleonic degrees of freedom and few-body systems. This book is an up-to-date introduction to the research planned with continuous beam electron accelerators.

Antimicrobial topical agents used in the vagina.

Science.gov (United States)

Frey Tirri, Brigitte

2011-01-01

Vaginally applied antimicrobial agents are widely used in the vagina in women with lower genital tract infections. An 'antimicrobial' is a general term that refers to a group of drugs that are effective against bacteria, fungi, viruses and protozoa. Topical treatments can be prescribed for a wide variety of vaginal infections. Many bacterial infections, such as bacterial vaginosis, desquamative inflammatory vaginitis or, as some European authors call it, aerobic vaginitis as well as infection with Staphylococcus aureus or group A streptococci, may be treated in this way. Candida vulvovaginitis is a fungal infection that is very amenable to topical treatment. The most common viral infections which can be treated with topical medications are condylomata acuminata and herpes simplex. The most often encountered protozoal vaginitis, which is caused by Trichomonas vaginalis, may be susceptible to topical medications, although this infection is treated systemically. This chapter covers the wide variety of commonly used topical antimicrobial agents for these diseases and focuses on the individual therapeutic agents and their clinical efficacy. In addition, potential difficulties that can occur in practice, as well as the usage of these medications in the special setting of pregnancy, are described in this chapter. Copyright © 2011 S. Karger AG, Basel.

Evapotranspiration (ET) covers.

Science.gov (United States)

Rock, Steve; Myers, Bill; Fiedler, Linda

2012-01-01

about specific projects using ET covers. There are three general approaches for non-conventional cover systems to achieve approval for installation; the first is when equivalent performance to conventional final cover systems can be demonstrated directly on site. This is the approach used by the Sandia study, by most ACAP sites, and the Rocky Mountain Arsenal. A second approach is used when there are data from a site specific study such as an ACAP installation at a site that has analogous soil and climate conditions. Several sites in Colorado and Southern California have achieved approval based on data from similar sites. The third most common approach for regulatory approval is by installation of data collection systems with the agreement that the permanence of the ET cover installation is contingent on success of the cover in meeting certain performance goals. This article is intended as an introduction to the topic and is not intended to serve as guidance for design or construction, nor indicate the appropriateness of using an ET cover systems at a particular site.

Analyzing research trends on drug safety using topic modeling.

Science.gov (United States)

Zou, Chen

2018-04-06

Published drug safety data has evolved in the past decade due to scientific and technological advances in the relevant research fields. Considering that a vast amount of scientific literature has been published in this area, it is not easy to identify the key information. Topic modeling has emerged as a powerful tool to extract meaningful information from a large volume of unstructured texts. Areas covered: We analyzed the titles and abstracts of 4347 articles in four journals dedicated to drug safety from 2007 to 2016. We applied Latent Dirichlet allocation (LDA) model to extract 50 main topics, and conducted trend analysis to explore the temporal popularity of these topics over years. Expert Opinion/Commentary: We found that 'benefit-risk assessment and communication', 'diabetes' and 'biologic therapy for autoimmune diseases' are the top 3 most published topics. The topics relevant to the use of electronic health records/observational data for safety surveillance are becoming increasingly popular over time. Meanwhile, there is a slight decrease in research on signal detection based on spontaneous reporting, although spontaneous reporting still plays an important role in benefit-risk assessment. The topics related to medical conditions and treatment showed highly dynamic patterns over time.

Minutes of the 28th Annual Plutonium Sample Exchange Meeting. Part II: metal sample exchange

International Nuclear Information System (INIS)

1984-01-01

Contents of this publication include the following list of participating laboratories; agenda; attendees; minutes of October 25 and 26 meeting; and handout materials supplied by speakers. The handout materials cover the following: statistics and reporting; plutonium - chemical assay 100% minus impurities; americium neptunium, uranium, carbon and iron data; emission spectroscopy data; plutonium metal sample exchange; the calorimetry sample exchange; chlorine determination in plutonium metal using phyrohydrolysis; spectrophotometric determination of 238-plutonium in oxide; plutonium measurement capabilities at the Savannah River Plant; and robotics in radiochemical laboratory

Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch.

Science.gov (United States)

Lionberger, David R; Brennan, Michael J

2010-11-10

The objective of this article is to review published clinical data on diclofenac epolamine topical patch 1.3% (DETP) in the treatment of acute soft tissue injuries, such as strains, sprains, and contusions. Review of published literature on topical nonsteroidal anti-inflammatory drugs (NSAIDs), diclofenac, and DETP in patients with acute soft tissue injuries was included. Relevant literature was identified on MEDLINE using the search terms topical NSAIDs, diclofenac, diclofenac epolamine, acute pain, sports injury, soft tissue injury, strain, sprain, and contusion, and from citations in retrieved articles covering the years 1978-2008. Review of published, randomized clinical trials and meta-analyses shows that topical NSAIDs are significantly more effective than placebo in relieving acute pain; the pooled average relative benefit was 1.7 (95% confidence interval, 1.5-1.9). In a limited number of comparisons, topical and oral NSAIDs provided comparable pain relief, but the use of topical agents produced lower plasma drug concentrations and fewer systemic adverse events (AEs). The physical-chemical properties of diclofenac epolamine make it well suited for topical use. In patients with acute soft tissue injuries treated with DETP, clinical data report an analgesic benefit within hours of the first application, and significant pain relief relative to placebo within 3 days. Moreover, DETP displayed tolerability comparable with placebo; the most common AEs were pruritus and other application site reactions. Review of published literature suggests that DETP is generally safe and well tolerated, clinically efficacious, and a rational treatment option for patients experiencing acute pain associated with strains, sprains, and contusions, and other localized painful conditions.

Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch

Directory of Open Access Journals (Sweden)

David R Lionberger

2010-11-01

Full Text Available David R Lionberger1, Michael J Brennan21Southwest Orthopedic Group, Houston, TX, USA; 2Department of Medicine, Bridgeport Hospital, Bridgeport, CT, USAAbstract: The objective of this article is to review published clinical data on diclofenac epolamine topical patch 1.3% (DETP in the treatment of acute soft tissue injuries, such as strains, sprains, and contusions. Review of published literature on topical nonsteroidal anti-inflammatory drugs (NSAIDs, diclofenac, and DETP in patients with acute soft tissue injuries was included. Relevant literature was identified on MEDLINE using the search terms topical NSAIDs, diclofenac, diclofenac epolamine, acute pain, sports injury, soft tissue injury, strain, sprain, and contusion, and from citations in retrieved articles covering the years 1978–2008. Review of published, randomized clinical trials and meta-analyses shows that topical NSAIDs are significantly more effective than placebo in relieving acute pain; the pooled average relative benefit was 1.7 (95% confidence interval, 1.5–1.9. In a limited number of comparisons, topical and oral NSAIDs provided comparable pain relief, but the use of topical agents produced lower plasma drug concentrations and fewer systemic adverse events (AEs. The physical–chemical properties of diclofenac epolamine make it well suited for topical use. In patients with acute soft tissue injuries treated with DETP, clinical data report an analgesic benefit within hours of the first application, and significant pain relief relative to placebo within 3 days. Moreover, DETP displayed tolerability comparable with placebo; the most common AEs were pruritus and other application site reactions. Review of published literature suggests that DETP is generally safe and well tolerated, clinically efficacious, and a rational treatment option for patients experiencing acute pain associated with strains, sprains, and contusions, and other localized painful conditions

Topics in radiation dosimetry radiation dosimetry

CERN Document Server

1972-01-01

Radiation Dosimetry, Supplement 1: Topics in Radiation Dosimetry covers instruments and techniques in dealing with special dosimetry problems. The book discusses thermoluminescence dosimetry in archeological dating; dosimetric applications of track etching; vacuum chambers of radiation measurement. The text also describes wall-less detectors in microdosimetry; dosimetry of low-energy X-rays; and the theory and general applicability of the gamma-ray theory of track effects to various systems. Dose equivalent determinations in neutron fields by means of moderator techniques; as well as developm

Hand-out: SFOE research conference on traffic technology and accumulators; Handout BFE-Forschungstagung Technologiebereich Verkehr Technologiebereich Akkumulatoren

Energy Technology Data Exchange (ETDEWEB)

NONE

2004-07-01

This comprehensive collection contains presentation slides presented at a research conference organised by the Swiss Federal Office of Energy (SFOE) at the Federal Institute of Science and Technology in Zurich in February 2004. Apart from two presentations on the future of the 'SwissEnergy' programme and research in the EU, fifteen further presentations are included. These cover the 'Cleaner Drive' project, the influence of lightweight electric vehicles on mobility behaviour, the advantages of 'EcoDrive' in the year 2010, results of a study on 'park-and-ride' facilities, the CO{sub 2}-effect, innovation, the possibilities offered by S-Cap capacitors and 'Sun Fuels'. Further contributions include the 'Downhill Coaster', weather-protection for bicycles, natural-gas fuelled buses, the operation of an Otto-motor using a petrol / natural gas / reformer gas mix, usage and optimisation of the 'Zebra' battery, innovative vehicles for the 'Novatlantis'-pilot region in Basle and a contribution on climate protection in the aviation area.

Topical Session on Materials Management

International Nuclear Information System (INIS)

2002-01-01

At its second meeting, in Paris, 5-7 December 2001, the WPDD held two topical sessions on the D and D Safety Case and on the Management of Materials from D and D, respectively. This report documents the topical session on the management of materials. Presentations during the topical session covered key aspects of the management of materials and meant to provide an exchange of information and experience, including: Experience and lessons learnt from VLLW and non-radioactive material management in Spain and Germany with special attention to recycling (How specific solutions came about? Are there 'generic' examples for wider adoption?); Risk assessment of recycling and non-recycling: a CPD study; Waste acceptance issues within different national contexts (What constraints are there on the waste receiving body and what flexibility can the latter have? What constraints does this impose on D and D implementers? What about wastes are without current solution? What needs to be done? What about large items and 'difficult' waste in general?); Radiological characterisation of materials during decommissioning, particularly difficult situations - large volumes, large items,.. wastes, heterogeneous streams (What examples of established practice? What are the approaches or aspects that set the regulatory requirements? How can the flow rates be large but the answers acceptable? How much is needed to be known for later action, e. g., disposal, release, protection of worker, etc.); Radiological characterisation of buildings as they stand, in order to allow conventional demolition (What are strategies for optimisation of characterisation? How much needs to be known to take action later? e.g. for storage, disposal, release, cost estimation and ALARA? What needs to be done in advance and after decommissioning/dismantling?). At the end of each presentation time was allotted for discussion of the paper. Integral to the Topical Session was a facilitated plenary discussion on the topical

Selected Topics in MicroNano-robotics for Biomedical Applications

CERN Document Server

2013-01-01

Selected Topics in Micro/Nano-robotics for Biomedical Applications features a system approach and incorporates modern methodologies in autonomous mobile robots for programmable and controllable micro/nano-robots aiming at biomedical applications. The book provides chapters of instructional materials and cutting-edge research results in micro/nanorobotics for biomedical applications. The book presents new sensing technology on nanofibers, new power supply techniques including miniature fuel cells and energy harvesting devices, and manipulation techniques including AFM-based nano-robotic manipulation, robot-aided optical tweezers, and robot-assisted catheter surgery systems. It also contains case studies on using micro/nano-robots in biomedical environments and in biomedicine, as well as a design example to conceptually develop a Vitamin-pill sized robot to enter human’s gastrointestinal tract. Each chapter covers a different topic of the highly interdisciplinary area. Bring together the selected topics into ...

Advanced topics in the arithmetic of elliptic curves

CERN Document Server

Silverman, Joseph H

1994-01-01

In the introduction to the first volume of The Arithmetic of Elliptic Curves (Springer-Verlag, 1986), I observed that "the theory of elliptic curves is rich, varied, and amazingly vast," and as a consequence, "many important topics had to be omitted." I included a brief introduction to ten additional topics as an appendix to the first volume, with the tacit understanding that eventually there might be a second volume containing the details. You are now holding that second volume. it turned out that even those ten topics would not fit Unfortunately, into a single book, so I was forced to make some choices. The following material is covered in this book: I. Elliptic and modular functions for the full modular group. II. Elliptic curves with complex multiplication. III. Elliptic surfaces and specialization theorems. IV. Neron models, Kodaira-Neron classification of special fibers, Tate's algorithm, and Ogg's conductor-discriminant formula. V. Tate's theory of q-curves over p-adic fields. VI. Neron's theory of can...

Recent advances and perspectives in topical oral anesthesia.

Science.gov (United States)

Franz-Montan, Michelle; Ribeiro, Lígia Nunes de Morais; Volpato, Maria Cristina; Cereda, Cintia Maria Saia; Groppo, Francisco Carlos; Tofoli, Giovana Randomille; de Araújo, Daniele Ribeiro; Santi, Patrizia; Padula, Cristina; de Paula, Eneida

2017-05-01

Topical anesthesia is widely used in dentistry to reduce pain caused by needle insertion and injection of the anesthetic. However, successful anesthesia is not always achieved using the formulations that are currently commercially available. As a result, local anesthesia is still one of the procedures that is most feared by dental patients. Drug delivery systems (DDSs) provide ways of improving the efficacy of topical agents. Areas covered: An overview of the structure and permeability of oral mucosa is given, followed by a review of DDSs designed for dental topical anesthesia and their related clinical trials. Chemical approaches to enhance permeation and anesthesia efficacy, or to promote superficial anesthesia, include nanostructured carriers (liposomes, cyclodextrins, polymeric nanoparticle systems, solid lipid nanoparticles, and nanostructured lipid carriers) and different pharmaceutical dosage forms (patches, bio- and mucoadhesive systems, and hydrogels). Physical methods include pre-cooling, vibration, iontophoresis, and microneedle arrays. Expert opinion: The combination of different chemical and physical methods is an attractive option for effective topical anesthesia in oral mucosa. This comprehensive review should provide the readers with the most relevant options currently available to assist pain-free dental anesthesia. The findings should be considered for future clinical trials.

AMNT 2014. Key topic: Reactor operation, safety - report. Pt. 2

International Nuclear Information System (INIS)

Fischer, Klaus-Christian; Willschuetz, Hans-Georg; Wortmann, Birgit

2014-01-01

Summary report on the following sessions of the Annual Conference on Nuclear Technology held in Frankfurt, 6 to 8 May 2014: - Thermo Dynamics and Fluid Dynamics: Experiments and Backfittings for the Improvement of Safety and Efficiency; - Safety of Nuclear Installations - Methods, Analyses, Results: In-Vessel Phenomena; Ex-Vessel Phenomena; - Standards and Regulations; Hazard and Safety Analysis; and Validation and Uncertainty Analysis. The other Sessions of the Key Topics 'Reactor Operation, Safety', 'Competence, Innovation, Regulation' and 'Fuel, Decommissioning and Disposal' have been covered in atw 10 (2014) and will be covered in further issues of atw.

AMNT 2014. Key topic: Reactor operation, safety - report. Pt. 3

Energy Technology Data Exchange (ETDEWEB)

Bohnstedt, Angelika [Karlsruher Institut fuer Technologie (KIT), Eggenstein-Leopoldshafen (Germany). Programm Nukleare Sicherheitsforschung (NUKLEAR); Mull, Thomas [AREVA GmbH, Erlangen (Germany). Nuclear Fusion, HTR and Transverse Issues (PTDH-G); Starflinger, Joerg [Stuttgart Univ. (Germany). Inst. fuer Kernenergetik und Energiesysteme (IKE)

2015-01-15

Summary report on the following sessions of the Annual Conference on Nuclear Technology held in Frankfurt, 6 to 8 May 2014: - Reactor Operation, Safety: Radiation Protection (Angelika Bohnstedt); - Competence, Innovation, Regulation: Fusion Technology - Optimisation Steps in the ITER Design (Thomas Mull); - Competence, Innovation, Regulation: Education, Expert Knowledge, Knowledge Transfer (Joerg Starflinger). The other Sessions of the Key Topics 'Reactor Operation, Safety', 'Competence, Innovation, Regulation' and 'Fuel, Decommissioning and Disposal' have been covered in atw 10 and 12 (2015) and will be covered in further issues of atw.

Introduction to International Trade.

Science.gov (United States)

Intercom, 1986

1986-01-01

Focusing mainly on United States-Japan relations, this issue provides 11 lesson plans and student handouts dealing with international trade topics such as protective tariffs, currency exchange rates, unofficial trade barriers, causes of unemployment, the balance of payments and the internationalization of the automobile industry. (JDH)

Topics in Finance Part I--Introduction and Stockholder Wealth Maximization

Science.gov (United States)

Laux, Judy

2010-01-01

The following article represents the first in a series dedicated to presenting students the opportunity to better understand the key theoretical constructs in the introductory financial management course. The current essay offers an introduction to the series and covers the topics of stockholder wealth maximization and its close cousin, agency…

Topical Session on Liabilities identification and long-term management at national level - Topical Session held during the 36. Meeting of the RWMC

International Nuclear Information System (INIS)

2003-01-01

These proceedings cover a topical session that was held at the March 2003 meeting of the Radioactive Waste Management Committee. The topical session focused on liability assessment and management for decommissioning of all types of nuclear installations, including decontamination of historic sites and waste management, as applicable. The presentations covered the current, national situations. The first oral presentation, from Switzerland, set the scene by providing a broad coverage of the relevant issues. The subsequent presentations - five from Member countries and one from the EC - described additional national positions and the evolving EC proposed directives. Each oral presentation was followed by a brief period of Q and As for clarification only. A plenary discussion took place on the ensemble of presentations and a Rapporteur provided a report on points made and lessons learnt. Additionally, written contributions were provided by RWMC delegates from several other countries. These are included in the proceedings as are the papers from the oral sessions, and the Rapporteur's report. These papers are not intended to be exhaustive, but to give an informed glimpse of NEA countries' approaches to liability identification and management in the context of nuclear facilities decommissioning and dismantling

A WOMAN-CENTRED CHILDBIRTH MODEL

African Journals Online (AJOL)

2009-10-27

Oct 27, 2009 ... outlined by Dickoff, James and Wiedenbach's (1968:423) survey list cited by Madela-Mntla (1999:69) .... In this research, the adequacy of the sample was attained when ..... Handouts on specific topics could be supplied as a method .... Creswell, J.W., 1994, Research design: Qualitative and quantitative.

Rx for Consumer Health Information: The Magic is in the Right Source

OpenAIRE

Blue, Ana Rosa; Curry, Jane

2010-01-01

Health information is one of the most popular topics requested, in libraries, by the public. These handouts supported the session titled: "Rx for Consumer Health Information: The Magic is in the Right Source" presented at the 2010 BC Library Conference (theme: Seriously Entertaining: Learning through Fun and Games).

Gun Control: The Debate and Public Policy.

Science.gov (United States)

Watkins, Christine

1997-01-01

Provides an overview and background information on the debate over gun control, as well as several teaching ideas. Handouts include a list of related topics drawn from various disciplines (economics, U.S. history), seven arguments for and against gun control, and a set of policy evaluation guidelines. (MJP)

Topics and topic prominence in two sign languages

NARCIS (Netherlands)

Kimmelman, V.

2015-01-01

In this paper we describe topic marking in Russian Sign Language (RSL) and Sign Language of the Netherlands (NGT) and discuss whether these languages should be considered topic prominent. The formal markers of topics in RSL are sentence-initial position, a prosodic break following the topic, and

Minutes of the 28th annual plutonium sample exchange meeting. Part I: isotopic sample exchange

International Nuclear Information System (INIS)

1984-01-01

Contents of this publication include the following: list of participating laboratories; agenda; attendees; minutes of October 24 meeting; and handout materials supplied by speakers. The handout materials cover the following: interlaboratory comparisons of plutonium isotope ratios. The plutonium ratios considered are 240/239, 241/239, 242/239, 238/239, 239/240, 241/240, 242/240, and 238/240; carbon, uranium, iron, and nickel data; mass spectroscopy data; determination of plutonium 241 half-life; review of plutonium overplating sample loading technique; on-line measurement evaluation system for isotopic analysis; and description of a new thermal ionization mass spectrometer

Is cost-covering remuneration fully booked? - Teething problems

International Nuclear Information System (INIS)

Niederhaeusern, A.

2009-01-01

In this interview with Michael Kaufmann, director of the SwissEnergy programme, possible strategies for the correct pricing of electricity and measures for the correction of the dissatisfactory situation now prevailing concerning the cost-covering remuneration of power from renewable sources are discussed. The pricing of electricity from various sources and the indirect costs that are at present not met by non-renewable resources are commented on. Further topics covered include suggestions for strategies for relieving the presently blocked financial promotion of renewables, the goals set for the role to be played by renewable energy in Swiss electricity production in 2030 and suggestions for future political action

What Patients Can Tell Us: Topic Analysis for Social Media on Breast Cancer.

Science.gov (United States)

Tapi Nzali, Mike Donald; Bringay, Sandra; Lavergne, Christian; Mollevi, Caroline; Opitz, Thomas

2017-07-31

Social media dedicated to health are increasingly used by patients and health professionals. They are rich textual resources with content generated through free exchange between patients. We are proposing a method to tackle the problem of retrieving clinically relevant information from such social media in order to analyze the quality of life of patients with breast cancer. Our aim was to detect the different topics discussed by patients on social media and to relate them to functional and symptomatic dimensions assessed in the internationally standardized self-administered questionnaires used in cancer clinical trials (European Organization for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire Core 30 [QLQ-C30] and breast cancer module [QLQ-BR23]). First, we applied a classic text mining technique, latent Dirichlet allocation (LDA), to detect the different topics discussed on social media dealing with breast cancer. We applied the LDA model to 2 datasets composed of messages extracted from public Facebook groups and from a public health forum (cancerdusein.org, a French breast cancer forum) with relevant preprocessing. Second, we applied a customized Jaccard coefficient to automatically compute similarity distance between the topics detected with LDA and the questions in the self-administered questionnaires used to study quality of life. Among the 23 topics present in the self-administered questionnaires, 22 matched with the topics discussed by patients on social media. Interestingly, these topics corresponded to 95% (22/23) of the forum and 86% (20/23) of the Facebook group topics. These figures underline that topics related to quality of life are an important concern for patients. However, 5 social media topics had no corresponding topic in the questionnaires, which do not cover all of the patients' concerns. Of these 5 topics, 2 could potentially be used in the questionnaires, and these 2 topics corresponded to a total of 3.10% (523

Assessing alternative measures of tree canopy cover: Photo-interpreted NAIP and ground-based estimates

Science.gov (United States)

Chris Toney; Greg Liknes; Andy Lister; Dacia Meneguzzo

2012-01-01

In preparation for the development of the National Land Cover Database (NLCD) 2011 tree canopy cover layer, a pilot project for research and method development was completed in 2010 by the USDA Forest Service Forest Inventory and Analysis (FIA) program and Remote Sensing Applications Center (RSAC).This paper explores one of several topics investigated during the NLCD...

#Healthy Selfies: Exploration of Health Topics on Instagram.

Science.gov (United States)

Muralidhara, Sachin; Paul, Michael J

2018-06-29

Social media provides a complementary source of information for public health surveillance. The dominate data source for this type of monitoring is the microblogging platform Twitter, which is convenient due to the free availability of public data. Less is known about the utility of other social media platforms, despite their popularity. This work aims to characterize the health topics that are prominently discussed in the image-sharing platform Instagram, as a step toward understanding how this data might be used for public health research. The study uses a topic modeling approach to discover topics in a dataset of 96,426 Instagram posts containing hashtags related to health. We use a polylingual topic model, initially developed for datasets in different natural languages, to model different modalities of data: hashtags, caption words, and image tags automatically extracted using a computer vision tool. We identified 47 health-related topics in the data (kappa=.77), covering ten broad categories: acute illness, alternative medicine, chronic illness and pain, diet, exercise, health care & medicine, mental health, musculoskeletal health and dermatology, sleep, and substance use. The most prevalent topics were related to diet (8,293/96,426; 8.6% of posts) and exercise (7,328/96,426; 7.6% of posts). A large and diverse set of health topics are discussed in Instagram. The extracted image tags were generally too coarse and noisy to be used for identifying posts but were in some cases accurate for identifying images relevant to studying diet and substance use. Instagram shows potential as a source of public health information, though limitations in data collection and metadata availability may limit its use in comparison to platforms like Twitter. ©Sachin Muralidhara, Michael J. Paul. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 29.06.2018.

Nanocrystal: a novel approach to overcome skin barriers for improved topical drug delivery.

Science.gov (United States)

Patel, Viral; Sharma, Om Prakash; Mehta, Tejal

2018-04-01

Skin is an important route of drug delivery for the treatment of various dermatological conditions. The advent of nanotechnology is paving the roadmaps for topical drug delivery by providing sustained release as well as maintaining a localized effect, outweighing the toxicity concern. Area covered: This review highlighted the morphology of skin, its barrier nature as well as drug penetration pathways after topical application of formulations. The existing methods to improve topical drug delivery, by infringing or permeating the skin barriers, are discussed. This context concretes the foundation to accentuate the need for the development of nanocrystal-based topical formulation. The mechanism of drug release, immediate as well as sustained release, after topical administration of drug nanocrystals is also elaborated. The special emphasis is given on the breakthrough achieved, in topical drug delivery using drug nanocrystals, so far in the plethora of literature, patents, and products, under clinical trial as well as in the market. Expert opinion: The current research on nanocrystals for topical drug delivery is highlighting the breakthroughs achieved so far. The output of these research envisages that topical nanocrystals based formulations can be a novel strategy for the drugs which are facing solubility, bioavailability and toxicity concerns.

Can Earth Materials BE Adequately Covered in a - or Two-Semester Course?

Science.gov (United States)

Hefferan, K. P.; O'Brien, J.

2007-12-01

Traditional geology programs offer courses in mineralogy, optical mineralogy, igneous petrology, metamorphic petrology, sedimentology and economic geology. At many universities this suite of mineralogy/petrology courses has been supplanted by a one-semester or two-semester Earth Materials course. This interactive poster poses five questions to faculty and students related to the means by which Earth Materials can be delivered: 1) Available online syllabi demonstrate a wide variation in the topics addressed in Earth Materials courses; is there a standard core of key topics that must be covered and in what level of detail? 2) Can a one-semester or two- semester Earth Materials course adequately cover these topics? 3) Excellent textbooks exist in both mineralogy and in petrology; what textbooks, if any, adequately encompass Earth Materials? 4) How has the online environment changed the way in which we use textbooks in the classroom? 5) Given the evolution of geology programs, higher education and the global economy in the past twenty years, what additional changes can be anticipated with respect to delivery and demand of Earth Materials topics? Answers-- or at least related discussions-- to these questions are encouraged via verbal dialogue among participants and/or by comments written on the poster. Our goal is to solicit faculty, student and industry feedback to create a textbook, curricula and online materials that support an Earth Materials course.

Satellite DNA: An Evolving Topic.

Science.gov (United States)

Garrido-Ramos, Manuel A

2017-09-18

Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot of literature has extensively covered various topics related to the structure, organization, function, and evolution of such sequences. Today, with the advent of genomic tools, the study of satellite DNA has regained a great interest. Thus, Next-Generation Sequencing (NGS), together with high-throughput in silico analysis of the information contained in NGS reads, has revolutionized the analysis of the repetitive fraction of the eukaryotic genomes. The whole of the historical and current approaches to the topic gives us a broad view of the function and evolution of satellite DNA and its role in chromosomal evolution. Currently, we have extensive information on the molecular, chromosomal, biological, and population factors that affect the evolutionary fate of satellite DNA, knowledge that gives rise to a series of hypotheses that get on well with each other about the origin, spreading, and evolution of satellite DNA. In this paper, I review these hypotheses from a methodological, conceptual, and historical perspective and frame them in the context of chromosomal organization and evolution.

Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline

Directory of Open Access Journals (Sweden)

Sertan Goktas

2014-01-01

Full Text Available Objective. To investigate the effects of topical and subconjunctival tigecycline on the prevention of corneal neovascularization. Materials and Methods. Following chemical burn, thirty-two rats were treated daily with topical instillation of 1 mg/mL tigecycline (group 1 or subconjunctival instillation of 1 mg/mL tigecycline (group 3 for 7 days. Control rats received topical (group 2 or subconjunctival (group 4 0.9% saline. Digital photographs of the cornea were taken on the eighth day after treatment and analyzed to determine the percentage area of the cornea covered by neovascularization. Corneal sections were analyzed histopathologically. Results. The median percentages of corneal neovascularization in groups 1 and 3 were 48% (95% confidence interval (CI, 44.2–55.8% and 33.5% (95% CI, 26.6–39.2%, respectively. The median percentages of corneal neovascularization of groups 1 and 3 were significantly lower than that of the control group (P=0.03 and P<0.001, resp.. Histologic examination of samples from groups 1 and 3 showed lower vascularity than that of control groups. Conclusion. Topical and subconjunctival administration of tigecycline seems to be showing promising therapeutic effects on the prevention of corneal neovascularization. Furthermore, subconjunctival administration of tigecycline is more potent than topical administration in the inhibition of corneal neovascularization.

Channeling Your Donna Reed Syndrome.

Science.gov (United States)

Mercer County Community Coll., Trenton, NJ.

This document offers materials on stress management used in a workplace literacy project developed by Mercer County Community College (New Jersey) and its partners. The document contains handouts on the following topics: (1) description of learners' typical days and identification of their stress points; (2) what stress is and is not; (3) a…

[Clip Sheets from BOCES. Opportunities. Health. Careers. = Oportunidades. Salud. Una Camera En...

Science.gov (United States)

State Univ. of New York, Geneseo. Coll. at Geneseo. Migrant Center.

This collection of 83 clip sheets, or classroom handouts, was created to help U.S. migrants learn more about health, careers, and general "opportunities" including education programs. They are written in both English and Spanish and are presented in an easily understandable format. Health clip-sheet topics include the following: Abuse; AIDS;…

AMNT 2014. Key Topic: Reactor operation, safety - report. Pt. 1

International Nuclear Information System (INIS)

Schaffrath, Andreas

2014-01-01

Summary report on one session of the Annual Conference on Nuclear Technology held in Frankfurt, 6 to 8 May 2014: - Safety of Nuclear Installations - Methods, Analysis, Results: Backfittings for the Improvement of Safety and Efficiency. The other Sessions of the Key Topics 'Reactor Operation, Safety', 'Competence, Innovation, Regulation' and 'Fuel, Decommissioning and Disposal' will be covered in further issues of atw.

Preface to Special Topic: Marine Renewable Energy

Energy Technology Data Exchange (ETDEWEB)

Pinto, F. T.; Iglesias, G.; Santos, P. R.; Deng, Zhiqun

2015-12-30

Marine renewable energy (MRE) is generates from waves, currents, tides, and thermal resources in the ocean. MRE has been identified as a potential commercial-scale source of renewable energy. This special topic presents a compilation of works selected from the 3rd IAHR Europe Congress, held in Porto, Portugal, in 2014. It covers different subjects relevant to MRE, including resource assessment, marine energy sector policies, energy source comparisons based on levelized cost, proof-of-concept and new-technology development for wave and tidal energy exploitation, and assessment of possible inference between wave energy converters (WEC).

Antibacterial drugs in the form of sprays for the topical treatment of pyodermas and dermatoses complicated with a secondary infection

Directory of Open Access Journals (Sweden)

YE. V. Matushevskaya

2014-01-01

Full Text Available The article covers issues related to the application of topical antibacterial drugs for the treatment of pyodermic skin diseases. The author describes mechanisms of action and advantages of the topical form of antibiotics and GCS for the topical treatment of pyodermas. The article substantiates indications for the administration of topical GCS drugs in a combination with antibacterial drugs. The efficacy and safety of antibacterial and combination topical drugs such as Neomycin, Oxycort and Polcortolon TC in the form sprays for the treatment of pyodermas and complicated forms of chronic dermatosis.

A Topic Analysis of ISECON Conference Proceedings from 1982 through 2014

Science.gov (United States)

Clark, Jon; Athey, Susan; Plotnicki, Jon; Barnes, Jay

2016-01-01

The authors note a distinct shift in topics covered in curricula as well as in conference presentations. This research was undertaken to get a better understanding of what these shifts have been, and determine their magnitude over time. Since ISECON has published its conference proceedings in digital format since 1982, this was a logical source of…

AMNT 2014. Key Topic: Reactor operation, safety - report. Pt. 1

Energy Technology Data Exchange (ETDEWEB)

Schaffrath, Andreas [Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH (GRS), Garching (Germany). Forschungszentrum

2014-10-15

Summary report on one session of the Annual Conference on Nuclear Technology held in Frankfurt, 6 to 8 May 2014: - Safety of Nuclear Installations - Methods, Analysis, Results: Backfittings for the Improvement of Safety and Efficiency. The other Sessions of the Key Topics 'Reactor Operation, Safety', 'Competence, Innovation, Regulation' and 'Fuel, Decommissioning and Disposal' will be covered in further issues of atw.

Top Ten Secrets for a Successful Workshop

Science.gov (United States)

Johnson, Doug

2006-01-01

In this article, the author provides 10 suggestions for a successful workshop, including advice and examples: (1) Know your role; (2) Limit your topic; (3) Be organized and communicate that organization; (4) Set out a problem or possibility; then offer a solution or opportunity; (5) Be conversational and have fun; (6) Good handouts and good slides…

Improved Food Drying and Storage Training Manual.

Science.gov (United States)

Zweig, Peter R.; And Others

This manual is intended to serve as a guide for those who are helping future Peace Corps volunteers to acquire basic food drying and storage skills. Included in the guide are lesson outlines and handouts for use in each of the 30 sessions of the course. Representative topics discussed in the individual sessions are scheduling, solar dryers,…

Using NASA Space Imaging Technology to Teach Earth and Sun Topics

Science.gov (United States)

Verner, E.; Bruhweiler, F. C.; Long, T.

2011-12-01

We teach an experimental college-level course, directed toward elementary education majors, emphasizing "hands-on" activities that can be easily applied to the elementary classroom. This course, Physics 240: "The Sun-Earth Connection" includes various ways to study selected topics in physics, earth science, and basic astronomy. Our lesson plans and EPO materials make extensive use of NASA imagery and cover topics about magnetism, the solar photospheric, chromospheric, coronal spectra, as well as earth science and climate. In addition we are developing and will cover topics on ecosystem structure, biomass and water on Earth. We strive to free the non-science undergraduate from the "fear of science" and replace it with the excitement of science such that these future teachers will carry this excitement to their future students. Hands-on experiments, computer simulations, analysis of real NASA data, and vigorous seminar discussions are blended in an inquiry-driven curriculum to instill confident understanding of basic physical science and modern, effective methods for teaching it. The course also demonstrates ways how scientific thinking and hands-on activities could be implemented in the classroom. We have designed this course to provide the non-science student a confident basic understanding of physical science and modern, effective methods for teaching it. Most of topics were selected using National Science Standards and National Mathematics Standards that are addressed in grades K-8. The course focuses on helping education majors: 1) Build knowledge of scientific concepts and processes; 2) Understand the measurable attributes of objects and the units and methods of measurements; 3) Conduct data analysis (collecting, organizing, presenting scientific data, and to predict the result); 4) Use hands-on approaches to teach science; 5) Be familiar with Internet science teaching resources. Here we share our experiences and challenges we face while teaching this course.

Topical tags vs non-topical tags : Towards a bipartite classification?

NARCIS (Netherlands)

Basile, Valerio; Peroni, Silvio; Tamburini, Fabio; Vitali, Fabio

2015-01-01

In this paper we investigate whether it is possible to create a computational approach that allows us to distinguish topical tags (i.e. talking about the topic of a resource) and non-topical tags (i.e. describing aspects of a resource that are not related to its topic) in folksonomies, in a way that

Meeting of the ITPA Topical Group on Diagnostics

International Nuclear Information System (INIS)

Costley, A.E.; Donne, A.J.H.

2002-01-01

The first meeting of the International Tokamak Physics Activities (ITPA) Topical Group (TG) on diagnostics was held at the Ioffe Physical-Technical institute, St. Petersburg, Russian Federation, on 14-16 November 2001. In total 38 participants attended the meeting and all four ITPA partners (EU, JA, RF and US) were represented. This summary covers mainly the discussions at the TG meeting. The meeting immediately followed a progress meeting, held in the same location on 12-13 November 2001, on the efforts carried out in the Russian Federation on diagnostics for ITER and burning plasma experiments

Topical Ranibizumab as a Treatment of Corneal Neovascularization

Science.gov (United States)

Ferrari, Giulio; Dastjerdi, Mohammad H.; Okanobo, Andre; Cheng, Sheng-Fu; Amparo, Francisco; Nallasamy, Nambi; Dana, Reza

2014-01-01

Purpose To examine the effect of topical ranibizumab on clinically stable corneal neovascularization (NV). Methods This was a prospective, open-label, monocentric, uncontrolled, non-comparative study. Ten eyes of 9 patients with corneal NV received topical ranibizumab (1%) 4 times a day for 3 weeks with a follow-up of 16 weeks. The main corneal neovascularization outcome measures were: neovascular area (NA), the area occupied by the corneal neovessels; vessel caliber (VC), the mean diameter of the corneal neovessels; and invasion area (IA), the fraction of the total cornea area covered by the vessels. This study was conducted at the Massachusetts Eye and Ear Infirmary, Boston, MA, USA. Results Statistically significant decreases in NA (55.3%, P<0.001), which lasted through 16 weeks, and VC (59%, P<0.001), which continued to improve up to week 16, were observed after treatment. No significant decrease was observed in IA (12.3%, P=0.49). There was no statistically significant change in visual acuity or intraocular pressure. No adverse events ascribed to the treatment were noted. Conclusions Topical application of ranibizumab is effective in reducing the severity of corneal NV in the context of established corneal NV, mostly through decrease in VC rather than IA. PMID:23407316

OpenMPI and ExxonMobil Topics

Energy Technology Data Exchange (ETDEWEB)

Hjelm, Nathan Thomas [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Pritchard, Howard Porter [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2016-09-09

These are a series of slides for a presentation for ExxonMobil's visit to Los Alamos National Laboratory. Topics covered are: Open MPI - The Release Story, MPI-3 RMA in Open MPI, MPI dynamic process management and Open MPI, and new options with CLE 6. Open MPI RMA features are: since v2.0.0 full support for the MPI-3.1 specification, support for non-contiguous datatypes, support for direct use of the RDMA capabilities of high performance networks (Cray Gemini/Aries, Infiniband), starting in v2.1.0 will have support for using network atomic operations for MPI_Fetch_and_op and MPI_Compare_and_swap, tested with MPI_THREAD_MULTIPLE.

Recent Topical Research on Global, Energy, Health & Medical, and Tourism Economics, and Global Software

NARCIS (Netherlands)

C-L. Chang (Chia-Lin); M.J. McAleer (Michael)

2017-01-01

textabstractThe paper presents an overview of recent topical research on global, energy, health & medical, and tourism economics, and global software. We have interpreted “global” in the title of the Journal of Reviews on Global Economics to cover contributions that have a global impact on

Readability of patient education materials in ophthalmology: a single-institution study and systematic review.

Science.gov (United States)

Williams, Andrew M; Muir, Kelly W; Rosdahl, Jullia A

2016-08-03

Patient education materials should be written at a level that is understandable for patients with low health literacy. The aims of this study are (1) to review the literature on readability of ophthalmic patient education materials and (2) to evaluate and revise our institution's patient education materials about glaucoma using evidence-based guidelines on writing for patients with low health literacy. A systematic search was conducted on the PubMed/MEDLINE database for studies that have evaluated readability level of ophthalmic patient education materials, and the reported readability scores were assessed. Additionally, we collected evidence-based guidelines for writing easy-to-read patient education materials, and these recommendations were applied to revise 12 patient education handouts on various glaucoma topics at our institution. Readability measures, including Flesch-Kincaid Grade Level (FKGL), and word count were calculated for the original and revised documents. The original and revised versions of the handouts were then scored in random order by two glaucoma specialists using the Suitability Assessment of Materials (SAM) instrument, a grading scale used to evaluate suitability of health information materials for patients. Paired t test was used to analyze changes in readability measures, word count, and SAM score between original and revised handouts. Finally, five glaucoma patients were interviewed to discuss the revised materials, and patient feedback was analyzed qualitatively. Our literature search included 13 studies that evaluated a total of 950 educational materials. Among the mean FKGL readability scores reported in these studies, the median was 11 (representing an eleventh-grade reading level). At our institution, handouts' readability averaged a tenth-grade reading level (FKGL = 10.0 ± 1.6), but revising the handouts improved their readability to a sixth-grade reading level (FKGL = 6.4 ± 1.2) (p readability and suitability of

Topical diclofenac therapy for osteoarthritis: a meta-analysis of randomized controlled trials.

Science.gov (United States)

Deng, Zhen-Han; Zeng, Chao; Yang, Ye; Li, Yu-Sheng; Wei, Jie; Yang, Tuo; Li, Hui; Lei, Guang-Hua

2016-05-01

The objective of this study was to evaluate the efficacy and safety of topical diclofenac therapy for osteoarthritis (OA). A meta-analysis of randomized controlled trials was conducted. A comprehensive literature search, covering the databases of Medline, the Cochrane Central Register of Controlled Trials, and EMBASE, was conducted in September 2014 to identify the randomized controlled trials which adopted the topical diclofenac therapy for OA. A total of nine papers were included in this meta-analysis. Topical diclofenac appears to be effective in both pain relief (standard mean differences (SMD) = 0.40; 95 % confidence interval (CI) 0.19 to 0.62; P = 0.0003) and function improvement (SMD = 0.23; 95 % CI 0.03 to 0.43; P = 0.03) when compared with the control group. The sensitivity analysis and subgroup analysis showed that the result of pain intensity was stable and reliable, while the result of physical function improvement was vague. With respect to safety, topical diclofenac demonstrated a higher incidence of adverse events such as dry skin, rash, dermatitis, neck pain, and withdrawal. Topical diclofenac is effective in pain relief as a treatment of OA. It may also have a potential effect in function improvement, which needs further studies to be explored. Although, some adverse effects were observed in the application of topical diclofenac, none of them was serious.

The Optical Society's 2016 topical meeting on optical interference coatings: introduction.

Science.gov (United States)

Ristau, Detlev; Li, Li; Sargent, Robert; Sytchkova, Anna

2017-02-01

This feature issue of Applied Optics is dedicated to the 13th Topical Meeting on Optical Interference Coatings, which was held June 19-24, 2016, in Tucson, Arizona, USA. The conference, taking place every three years, is a focal point for global technical interchange in the field of optical interference coatings and provides premier opportunities for people working in the field to present their new advances in research and development. Papers presented at the meeting covered a broad range of topics, including fundamental research on coating design theory, new materials, and deposition and characterization technologies, as well as the vast and growing number of applications in electronic displays, communication, optical instruments, high power and ultra-fast lasers, solar cells, space missions, gravitational wave detection, and many others.

Changing the Topic. Topic Position in Ancient Greek Word Order

NARCIS (Netherlands)

Allan, R.J.

2014-01-01

Ancient Greek, topics can be expressed as intra-clausal constituents but they can also precede or follow the main clause as extra-clausal constituents. Together, these various topic expressions constitute a coherent system of complementary pragmatic functions. For a comprehensive account of topic

Topical Hazard Evaluation Program of Candidate Insect Repellent AI3- 39053a

Science.gov (United States)

1987-05-01

StudyNo. 75-51-O 71-R7 Mnay 19R71 12 PERSONAL AUTHOR(S) William T. Huebsam, SGT, U.S.A.; Maurice H. Weeks 1I8. TYPE Of REPORT 13b TIME COVERED 114...ARMY u.S. AUT ENVIVIf[NNIAL HYGINE AMIdT ASCROELN PROVING GROUND. MARYLAND M1蚉 HSHB-MO-T TOPICAL HAZARD EVALUATION PROGRAM OF CANDIDATE INSECT

Proceedings of the first topical meeting on Asian network for accelerator-driven systems and nuclear transmutation technology

International Nuclear Information System (INIS)

Sasa, Toshinobu

2016-03-01

The first topical meeting on Asian Network for Accelerator-driven System (ADS) and Nuclear Transmutation Technology (NTT) was held on 26-27 October 2015 at the J-PARC Center, Japan Atomic Energy Agency, Japan. The topical meeting was an optional one in-between the regular meeting, which is held in every two years. Instead of the regular meetings, which cover all research fields for ADS and NTT, such as accelerator, spallation target, subcritical reactor, fuel, and material, the topical meeting is focused on a specific topic to make technical discussions more deeply. In this meeting, the technology for lead-bismuth eutectic alloy was selected, as it was one of the hot issues in the world, and the topic was deeply discussed by specialists in Asian countries. This report summarizes all presentation materials discussed in the meeting. (author)

A Legal Odyssey, 2001. Papers [of the] Education Law Association Conference (47th, Albuquerque, New Mexico, November 15-17, 2001). Topic Outlines.

Science.gov (United States)

Education Law Association, Dayton, OH.

This document is a collection of 53 topic outlines and conference papers whose topics cover a multitude of aspects of educational law. Subjects include the impacts of the Individuals with Disabilities Education Act (IDEA) on "normal" students, rights of nontenured teachers, sexual discrimination and harassment, school disciplinary issues,…

46th Annual meeting on nuclear technology (AMNT 2015). Key topic / Enhanced safety and operation excellence / Sustainable reactor operation management - safe, efficient, valuable

International Nuclear Information System (INIS)

Fischer, Erwin

2015-01-01

Summary report on the following Topical Session of the 46 th Annual Conference on Nuclear Technology (AMNT 2015) held in Berlin, 5 to 7 May 2015: - Sustainable Reactor Operation Management - Safe, Efficient, Valuable (Erwin Fischer) The other Sessions of the Key Topics - ''Outstanding Know-How and Sustainable Innovations'', - ''Enhanced Safety and Operation Excellence'' and - ''Decommissioning Experience and Waste Management Solutions'' have been covered in atw 7 (2015) and will be covered in further issues of atw.

Atom probe field ion microscopy and related topics: A bibliography 1989

International Nuclear Information System (INIS)

Miller, M.K.; Hawkins, A.R.; Russell, K.F.

1990-12-01

This bibliography includes references related to the following topics: atom probe field ion microscopy (APFIM), field ion spectroscopy (FIM), field emission microscopy (FEM), liquid metal ion sources (LMIS), scanning tunneling microscopy (STM), and theory. Technique-orientated studies and applications are included. This bibliography covers the period 1989. The references contained in this document were compiled from a variety of sources including computer searches and personal lists of publications

SASP. Contributions to the 13. Symposium on atomic and surface physics and related topics

Energy Technology Data Exchange (ETDEWEB)

Scheier, P; Maerk, T [eds.

2002-07-01

The XIII symposium on Atomic and Surface Physics and related Topics (SASP) is devoted to cover the research of interactions between ions, electrons, photons, atoms, molecules and clusters and their interaction with surfaces. This year there was a special session dedicated to proton transfer reaction mass spectrometry covering its applications in different fields and a mini symposium on the radiation action on bio-molecules such as uracil. The contributions included in the proceeding correspond to invited lectures and poster sessions, consisting of short and extended abstracts as well as short articles. (nevyjel)

SASP. Contributions to the 13. Symposium on atomic and surface physics and related topics

International Nuclear Information System (INIS)

Scheier, P.; Maerk, T.

2002-01-01

The XIII symposium on Atomic and Surface Physics and related Topics (SASP) is devoted to cover the research of interactions between ions, electrons, photons, atoms, molecules and clusters and their interaction with surfaces. This year there was a special session dedicated to proton transfer reaction mass spectrometry covering its applications in different fields and a mini symposium on the radiation action on bio-molecules such as uracil. The contributions included in the proceeding correspond to invited lectures and poster sessions, consisting of short and extended abstracts as well as short articles. (nevyjel)

Linear algebra and matrices topics for a second course

CERN Document Server

Shapiro, Helene

2015-01-01

Linear algebra and matrix theory are fundamental tools for almost every area of mathematics, both pure and applied. This book combines coverage of core topics with an introduction to some areas in which linear algebra plays a key role, for example, block designs, directed graphs, error correcting codes, and linear dynamical systems. Notable features include a discussion of the Weyr characteristic and Weyr canonical forms, and their relationship to the better-known Jordan canonical form; the use of block cyclic matrices and directed graphs to prove Frobenius's theorem on the structure of the eigenvalues of a nonnegative, irreducible matrix; and the inclusion of such combinatorial topics as BIBDs, Hadamard matrices, and strongly regular graphs. Also included are McCoy's theorem about matrices with property P, the Bruck-Ryser-Chowla theorem on the existence of block designs, and an introduction to Markov chains. This book is intended for those who are familiar with the linear algebra covered in a typical first c...

46{sup th} Annual meeting on nuclear technology (AMNT 2015). Key topic / Enhanced safety and operation excellence / Sustainable reactor operation management - safe, efficient, valuable

Energy Technology Data Exchange (ETDEWEB)

Fischer, Erwin [E.ON Kernkraft GmbH, Global Unit Next Generation, Hannover (Germany)

2015-08-15

Summary report on the following Topical Session of the 46{sup th} Annual Conference on Nuclear Technology (AMNT 2015) held in Berlin, 5 to 7 May 2015: - Sustainable Reactor Operation Management - Safe, Efficient, Valuable (Erwin Fischer) The other Sessions of the Key Topics - ''Outstanding Know-How and Sustainable Innovations'', - ''Enhanced Safety and Operation Excellence'' and - ''Decommissioning Experience and Waste Management Solutions'' have been covered in atw 7 (2015) and will be covered in further issues of atw.

Topics raised by the summary report of the first review meeting

International Nuclear Information System (INIS)

2001-01-01

This document presents the fulfilling of the Brazilian obligations under the Convention on Nuclear Safety. The Chapter 7 of the document contains topics raised by the summary report of the first review meeting. The chapter covers status and position of the regulatory body, collective doses, effluents release trends, adoption of the ICRP 60 and basic safety standards, regulatory strategy, quality assurance, monitoring safety management, international cooperation, probabilistic safety assessment and safety improvement programmes

Topics in extragalactic astronomy with special reference to the southern hemisphere

International Nuclear Information System (INIS)

Vaucouleurs, G. De

1977-01-01

The following topics are covered: classification of galaxies; photometry, colorimetry, spectrophotometry of galaxies; type I supernovae as checks of cosmological models; diameters of galaxies; extragalactic distance indicators; Local Group and nearby group of galaxies; structure of the Local Supercluster of galaxies; anisotropy of the redshifts and kinematics of the Local Supercluster; large scale distribution of galaxies and clusters of galaxies; galaxy counts and probes in depth; problems in the southern hemisphere. (U.K.)

A Descriptive Study of Television News Coverage of Tobacco in the United States: Frequency of Topics, Frames, Exemplars, and Efficacy

Science.gov (United States)

BLAKE, KELLY D.; KAUFMAN, ANNETTE R.; LORENZO, JOSHUA; AUGUSTSON, ERIK M.

2015-01-01

There is a positive correlation between recall of tobacco-related television news and perceived risks of smoking and thoughts about quitting. The authors used Cision US, Inc., to create a sampling frame (N =61,027) of local and national television news coverage of tobacco from October 1, 2008, to September 30, 2009, and to draw a nationally representative sample (N =730) for content analysis. The authors conducted a descriptive study to determine the frequency and proportion of stories containing specified tobacco topics, frames, sources, and action messages, and the valence of the coverage. Valence was generally neutral; 68% of stories took a balanced stance, with 26% having a tenor supportive of tobacco control and 6% opposing tobacco control. The most frequently covered topics included smoking bans (n =195) and cessation (n =156). The least covered topics included hookah (n =1) and menthol (n =0). The majority of coverage lacked quoting any source (n =345); government officials (n =144) were the most quoted sources. Coverage lacked action messages or resources; 29 stories (Television news can be leveraged by health communication professionals to increase awareness of underrepresented topics in tobacco control. PMID:26176379

Recent topical research on global, energy, health & medical, and tourism economics, and global software: An overview

NARCIS (Netherlands)

C-L. Chang (Chia-Lin); M.J. McAleer (Michael)

2017-01-01

textabstractThe paper presents an overview of recent topical research on global, energy, health & medical, and tourism economics, and global software. We have interpreted "global" in the title of the Journal of Reviews on Global Economics to cover contributions that have a global impact on

Freshman Health Topics

Science.gov (United States)

Hovde, Karen

2011-01-01

This article examines a cluster of health topics that are frequently selected by students in lower division classes. Topics address issues relating to addictive substances, including alcohol and tobacco, eating disorders, obesity, and dieting. Analysis of the topics examines their interrelationships and organization in the reference literature.…

Specialists' meeting on heat and mass transfer in the reactor cover gas, Harwell, England, 8-10 October 1985

International Nuclear Information System (INIS)

1986-07-01

The specialists' meeting on ''Heat and Mass Transfer in the Reactor Cover Gas'' was held at Harwell, the United Kingdom, on 8-10 October 1985. It was attended by 24 participants from all IWGFR member-countries: France, the Federal Republic of Germany, India, Italy, Japan, the Union of Soviet Socialist Republics, the United Kingdom and the United States. The meeting was presided over by Dr K. Eickhoff of the United Kingdom. The following topical areas were reviewed and discussed during the meeting: 1. National review presentations on the status of activities on heat and mass transfer in the reactor cover gas - 2 papers; 2. Aerosol dynamics - 4 papers; 3. Aerosol trapping - 2 papers; 4. Heat and mass transfer through cover gas in annuli - 3 papers; 5. Radiative properties - 4 papers; 6. Modelling of cover gas - 4 papers. A separate abstract was prepared for each of these papers. On the basis of papers presented and discussed by participants, session summaries and conclusions were drafted on the above topical areas. These summaries, as well as general conclusions and recommendations of the meeting were reviewed and agreed upon by consensus at the end of the meeting

Academicians' and Practitioners' Views on the Importance of the Topical Content in the First Auditing Course

Science.gov (United States)

Armitage, Jack; Poyzer, Jillian K.

2010-01-01

The research question addressed in this study is to compare and identify differences between academics teaching auditing classes and practicing accountants regarding the importance of topics covered in the first university auditing course. This is accomplished by surveying academics and practitioners regarding their perceptions of the importance…

Evaluating topic models with stability

CSIR Research Space (South Africa)

De Waal, A

2008-11-01

Full Text Available Topic models are unsupervised techniques that extract likely topics from text corpora, by creating probabilistic word-topic and topic-document associations. Evaluation of topic models is a challenge because (a) topic models are often employed...

Topical report review status

International Nuclear Information System (INIS)

1997-08-01

This report provides industry with procedures for submitting topical reports, guidance on how the U.S. Nuclear Regulatory Commission (NRC) processes and responds to topical report submittals, and an accounting, with review schedules, of all topical reports currently accepted for review schedules, of all topical reports currently accepted for review by the NRC. This report will be published annually. Each sponsoring organization with one or more topical reports accepted for review copies

Global pattern for the effect of climate and land cover on water yield

Science.gov (United States)

Guoy Zhou; Xiaohua Wei; Xiuzhi Chen; Ping Zhou; Xiaodong Liu; Yin Xiao; Ge Sun; David F. Scott; Shuyidan Zhou; Liusheng Hano; Yongxian Su

2015-01-01

Research results on the effects of land cover change on water resources vary greatly and the topic remains controversial. Here we use published data worldwide to examine the validity of Fuh’s equation, which relates annual water yield (R) to a wetness index (precipitation/ potential evapotranspiration; P/PET) and watershed characteristics (m). We identify two critical...

Syntacticized topics in Kurmuk

DEFF Research Database (Denmark)

Andersen, Torben

2015-01-01

This article argues that Kurmuk, a little-described Western Nilotic language, is characterized by a syntacticized topic whose grammatical relation is variable. In this language, declarative clauses have as topic an obligatory preverbal NP which is either a subject, an object or an adjunct....... The grammatical relation of the topic is expressed by a voice-like inflection of the verb, here called orientation. While subject-orientation is morphologically unmarked, object-oriented and adjunct-oriented verbs are marked by a subject suffix or by a suffix indicating that the topic is not subject, and adjunct......-orientation differs from object-orientation by a marked tone pattern. Topic choice largely reflects information structure by indicating topic continuity. The topic also plays a crucial role in relative clauses and in clauses with contrastive constituent focus, in that objects and adjuncts can only be relativized...

Evaluation of Novel Antimicrobial Peptides as Topical Anti-Infectives with Broad Spectrum Activity Against Combat-Related Bacterial and Fungal Wound Infections

Science.gov (United States)

2016-10-01

Inc. Vallejo, CA 94592 REPORT DATE: October 2016 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort...2016 2. REPORT TYPE Annual 3. DATES COVERED 30 Sep 2015 - 29 Sep 2016 4. TITLE AND SUBTITLE Evaluation of Novel Antimicrobial Peptides as Topical...antibiotics and early debridement has been associated with a large reduction in burn wound infections. Current topical antibiotics include

2nd Topical Workshop on Laser Technology and Optics Design

CERN Document Server

2013-01-01

Lasers have a variety of applications in particle accelerator operation and will play a key role in the development of future particle accelerators by improving the generation of high brightness electron and exotic ion beams and through increasing the acceleration gradient. Lasers will also make an increasingly important contribution to the characterization of many complex particle beams by means of laser-based beam diagnostics methods. The second LANET topical workshop will address the key aspects of laser technology and optics design relevant to laser application to accelerators. The workshop will cover general optics design, provide an overview of different laser sources and discuss methods to characterize beams in details. Participants will be able to choose from a range of topical areas that go deeper in more specific aspects including tuneable lasers, design of transfer lines, noise sources and their elimination and non-linear optics effects. The format of the workshop will be mainly training-based wit...

Melanoma or Pseudo melanoma Change in a pigmented lesion after application of topical 5-Fluorouracil

Science.gov (United States)

2017-10-26

2. REPORT TYPE 3. DATES COVERED (From - To) 10/26/2017 Poster 10/26/2017-10/29/2017 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Melanoma or Pseudo...melanoma? Change in a pigmented lesion after application of topical 5-Fluorouracil. 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d

Fertilizer and Lime: Why They Are Used.

Science.gov (United States)

McCaslin, Judith Strand

This unit teaching guide is designed to help teachers explain the principles of fertilizer and lime use. The first of four major sections is a teaching outline keyed to transparency masters and student handouts. Thirteen major areas are covered in the teaching outline: (1) plant needs; (2) uses of fertilizer; (3) nutrients for plant growth; (4)…

Car Covers | Outdoor Covers Canada

OpenAIRE

Covers, Outdoor

2018-01-01

Protect your car from the elements with Ultimate Touch Car Cover. The multi-layer non-woven fabric is soft on the finish and offers 4 seasons all weather protection.https://outdoorcovers.ca/car-covers/

Topical Drugs for Pain Relief

Directory of Open Access Journals (Sweden)

Anjali Srinivasan

2015-03-01

Full Text Available Topical therapy helps patients with oral and perioral pain problems such as ulcers, burning mouth syndrome, temporomandibular disorders, neuromas, neuropathies and neuralgias. Topical drugs used in the field of dentistry are topical anaesthetics, topical analgesics, topical antibiotics and topical corticosteroids. It provides symptomatic/curative effect. Topical drugs are easy to apply, avoids hepatic first pass metabolism and more sites specific. But it can only be used for medications that require low plasma concentrations to achieve a therapeutic effect.

Ocean waste disposal. A bibliography with abstracts. Search period covered 1964--May 1975

International Nuclear Information System (INIS)

1975-01-01

The majority of the cited topics discuss the ocean disposal of sewage, sewage sludge, and dredged material, although reports on the disposal of radioactive wastes, brines, and industrial wastes are also covered. The ecological effects are included, as is research on the pollution of the New York Bight. However, studies on the discharge of heated effluents is excluded. Contains 164 abstracts. (auth)

Metallic iron for water treatment and environmental remediation: A handout to young researchers

OpenAIRE

Nkundimana, Emmanuel; Noubactep, Chicgoua; Uwamariya, Valentine

2015-01-01

The premise of this research note is that current research on metallic iron (Fe0) for environmental remediation and water treatment has started on a biased basis. Before expecting experienced researchers to correct flawed approaches compromising the future of the technology, the attention of new researchers should be drawn on the prevailing flawed conceptual models. There are guides on how to select good research topics, to perform good literature review, to select good mentors, and to write ...

Advanced topics in control and estimation of state-multiplicative noisy systems

CERN Document Server

Gershon, Eli

2013-01-01

Advanced Topics in Control and Estimation of State-Multiplicative Noisy Systems begins with an introduction and extensive literature survey. The text proceeds to cover solutions of measurement-feedback control and state problems and the formulation of the Bounded Real Lemma for both continuous- and discrete-time systems. The continuous-time reduced-order and stochastic-tracking control problems for delayed systems are then treated. Ideas of nonlinear stability are introduced for infinite-horizon systems, again, in both the continuous- and discrete-time cases. The reader is introduced to six practical examples of noisy state-multiplicative control and filtering associated with various fields of control engineering. The book is rounded out by a three-part appendix containing stochastic tools necessary for a proper appreciation of the text: a basic introduction to nonlinear stochastic differential equations and aspects of switched systems and peak to peak  optimal control and filtering. Advanced Topics in Contr...

Topical report review status

International Nuclear Information System (INIS)

1982-08-01

A Topical Report Review Status is scheduled to be published semi-annually. The primary purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the Nuclear Regulatory Commission (NRC) staff review has been completed and, to the extent practicable, to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility. This status report is published primarily for internal NRC use in managing the topical report program, but is also used by NRC to advise the industry of report review status

Topical report review status

International Nuclear Information System (INIS)

1983-01-01

A Topical Report Review Status is scheduled to be published semi-annually. The primary purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the Nuclear Regulatory Commission (NRC) staff review has been completed and, to the extent practicable, to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility. This status report is published primarily for internal NRC use in managing the topical report program, but is also used by NRC to advise the industry of report review status

75 FR 26647 - Ophthalmic and Topical Dosage Form New Animal Drugs; Ivermectin Topical Solution

Science.gov (United States)

2010-05-12

.... FDA-2010-N-0002] Ophthalmic and Topical Dosage Form New Animal Drugs; Ivermectin Topical Solution... are treated with a topical solution of ivermectin. DATES: This rule is effective May 12, 2010. FOR... ANADA 200-340 for PRIVERMECTIN (ivermectin), a topical solution used on cattle to control infestations...

Women's Health Topics

Science.gov (United States)

... Information by Audience For Women Women's Health Topics Women's Health Topics Share Tweet Linkedin Pin it More sharing options Linkedin Pin it Email Print National Women's Health Week May 13 - 19, 2018 Join us ...

Developments in functional equations and related topics

CERN Document Server

Ciepliński, Krzysztof; Rassias, Themistocles

2017-01-01

This book presents current research on Ulam stability for functional equations and inequalities. Contributions from renowned scientists emphasize fundamental and new results, methods and techniques. Detailed examples are given to theories to further understanding at the graduate level for students in mathematics, physics, and engineering. Key topics covered in this book include: Quasi means Approximate isometries Functional equations in hypergroups Stability of functional equations Fischer-Muszély equation Haar meager sets and Haar null sets Dynamical systems Functional equations in probability theory Stochastic convex ordering Dhombres functional equation Nonstandard analysis and Ulam stability This book is dedicated in memory of Staniłsaw Marcin Ulam, who posed the fundamental problem concerning approximate homomorphisms of groups in 1940; which has provided the stimulus for studies in the stability of functional equations and inequalities.

Topics in the generalized vector dominance model

International Nuclear Information System (INIS)

Chavin, S.

1976-01-01

Two topics are covered in the generalized vector dominance model. In the first topic a model is constructed for dilepton production in hadron-hadron interactions based on the idea of generalized vector-dominance. It is argued that in the high mass region the generalized vector-dominance model and the Drell-Yan parton model are alternative descriptions of the same underlying physics. In the low mass regions the models differ; the vector-dominance approach predicts a greater production of dileptons. It is found that the high mass vector mesons which are the hallmark of the generalized vector-dominance model make little contribution to the large yield of leptons observed in the transverse-momentum range 1 less than p/sub perpendicular/ less than 6 GeV. The recently measured hadronic parameters lead one to believe that detailed fits to the data are possible under the model. The possibility was expected, and illustrated with a simple model the extreme sensitivity of the large-p/sub perpendicular/ lepton yield to the large-transverse-momentum tail of vector-meson production. The second topic is an attempt to explain the mysterious phenomenon of photon shadowing in nuclei utilizing the contribution of the longitudinally polarized photon. It is argued that if the scalar photon anti-shadows, it could compensate for the transverse photon, which is presumed to shadow. It is found in a very simple model that the scalar photon could indeed anti-shadow. The principal feature of the model is a cancellation of amplitudes. The scheme is consistent with scalar photon-nucleon data as well. The idea is tested with two simple GVDM models and finds that the anti-shadowing contribution of the scalar photon is not sufficient to compensate for the contribution of the transverse photon. It is found doubtful that the scalar photon makes a significant contribution to the total photon-nuclear cross section

Atom probe field ion microscopy and related topics: A bibliography 1993

Energy Technology Data Exchange (ETDEWEB)

Godfrey, R.D.; Miller, M.K.; Russell, K.F.

1994-10-01

This bibliography, covering the period 1993, includes references related to the following topics: atom probe field ion microscopy (APFIM), field emission (FE), and field ion microscopy (FIM). Technique-oriented studies and applications are included. The references contained in this document were compiled from a variety of sources including computer searches and personal lists of publications. To reduce the length of this document, the references have been reduced to the minimum necessary to locate the articles. The references are listed alphabetically by authors, an Addendum of references missed in previous bibliographies is included.

Atom probe field ion microscopy and related topics: A bibliography 1993

International Nuclear Information System (INIS)

Godfrey, R.D.; Miller, M.K.; Russell, K.F.

1994-10-01

This bibliography, covering the period 1993, includes references related to the following topics: atom probe field ion microscopy (APFIM), field emission (FE), and field ion microscopy (FIM). Technique-oriented studies and applications are included. The references contained in this document were compiled from a variety of sources including computer searches and personal lists of publications. To reduce the length of this document, the references have been reduced to the minimum necessary to locate the articles. The references are listed alphabetically by authors, an Addendum of references missed in previous bibliographies is included

Topical Session on the Decommissioning and Dismantling Safety Case

International Nuclear Information System (INIS)

2002-01-01

practices is low, the idea being that it is important to understand differences in approaches. Frances Taylor, Head of Radioactive Waste Management and Decommissioning Strategy Unit, HM Nuclear Installations Inspectorate, Health and Safety Executive, served as Session Chair. Scott Moore, Section Chief of the Special Projects section, U.S. Nuclear Regulatory Commission, served as the Rapporteur for the Topical Session. Presentations during the topical session covered key aspects of the safety case, including: - international requirements and guidance, - environmental impact assessment, - plant configuration and decommissioning and dismantling (D and D) licensing, - accident assessment, - balancing radiological and industrial risk, and - the safety case for safe store and dormancy periods. At the end of each presentation time was allotted for discussion of the paper. Integral to the Topical Session was a facilitated plenary discussion on the topical issues identified above. The Rapporteur briefly reviewed the main points at the end of the topical session. The Topical Session is documented as follows. First a summary of the presentations is given along with the questions that were asked of each speaker; then follow a summary of the plenary discussions and the main points made. The extended abstracts or full papers supporting each presentation are given in Appendix 1. As a follow-on to the Topical Session a Task Group has been constituted in order to propose to the WPDD a more detailed work programme in this area

Topic Visualization and Survival Analysis

OpenAIRE

Wang, Ping Jr

2017-01-01

Latent semantic structure in a text collection is called a topic. In this thesis, we aim to visualize topics in the scientific literature and detect active or inactive research areas based on their lifetime. Topics were extracted from over 1 million abstracts from the arXiv.org database using Latent Dirichlet Allocation (LDA). Hellinger distance measures similarity between two topics. Topics are determined to be relevant if their pairwise distances are smaller than the threshold of Hellinger ...

GeneTopics - interpretation of gene sets via literature-driven topic models

Science.gov (United States)

2013-01-01

Background Annotation of a set of genes is often accomplished through comparison to a library of labelled gene sets such as biological processes or canonical pathways. However, this approach might fail if the employed libraries are not up to date with the latest research, don't capture relevant biological themes or are curated at a different level of granularity than is required to appropriately analyze the input gene set. At the same time, the vast biomedical literature offers an unstructured repository of the latest research findings that can be tapped to provide thematic sub-groupings for any input gene set. Methods Our proposed method relies on a gene-specific text corpus and extracts commonalities between documents in an unsupervised manner using a topic model approach. We automatically determine the number of topics summarizing the corpus and calculate a gene relevancy score for each topic allowing us to eliminate non-specific topics. As a result we obtain a set of literature topics in which each topic is associated with a subset of the input genes providing directly interpretable keywords and corresponding documents for literature research. Results We validate our method based on labelled gene sets from the KEGG metabolic pathway collection and the genetic association database (GAD) and show that the approach is able to detect topics consistent with the labelled annotation. Furthermore, we discuss the results on three different types of experimentally derived gene sets, (1) differentially expressed genes from a cardiac hypertrophy experiment in mice, (2) altered transcript abundance in human pancreatic beta cells, and (3) genes implicated by GWA studies to be associated with metabolite levels in a healthy population. In all three cases, we are able to replicate findings from the original papers in a quick and semi-automated manner. Conclusions Our approach provides a novel way of automatically generating meaningful annotations for gene sets that are directly

47{sup th} Annual meeting on nuclear technology (AMNT 2016). Key Topics / Enhanced safety and operation excellence

Energy Technology Data Exchange (ETDEWEB)

Bohnstedt, Angelika [Karlsruher Institut fuer Technologie (KIT), Eggenstein-Leopoldshafen (Germany). Programm Nukleare Entsorgung, Sicherheit und Strahlenforschung (NUSAFE); Baumann, Erik [AREVA GmbH, Erlangen (Germany). Radiation Protection

2016-12-15

Summary report on the Key Topic 'Enhanced Safety and Operation Excellence' Focus Session 'Radiation Protection' of the 47{sup th} Annual Meeting on Nuclear Technology (AMNT 2016) held in Hamburg, 10 to 12 May 2016. Other Sessions of AMNT 2016 have been and will be covered in further issues of atw.

Incorporating Topic Assignment Constraint and Topic Correlation Limitation into Clinical Goal Discovering for Clinical Pathway Mining

Directory of Open Access Journals (Sweden)

Xiao Xu

2017-01-01

Full Text Available Clinical pathways are widely used around the world for providing quality medical treatment and controlling healthcare cost. However, the expert-designed clinical pathways can hardly deal with the variances among hospitals and patients. It calls for more dynamic and adaptive process, which is derived from various clinical data. Topic-based clinical pathway mining is an effective approach to discover a concise process model. Through this approach, the latent topics found by latent Dirichlet allocation (LDA represent the clinical goals. And process mining methods are used to extract the temporal relations between these topics. However, the topic quality is usually not desirable due to the low performance of the LDA in clinical data. In this paper, we incorporate topic assignment constraint and topic correlation limitation into the LDA to enhance the ability of discovering high-quality topics. Two real-world datasets are used to evaluate the proposed method. The results show that the topics discovered by our method are with higher coherence, informativeness, and coverage than the original LDA. These quality topics are suitable to represent the clinical goals. Also, we illustrate that our method is effective in generating a comprehensive topic-based clinical pathway model.

Health Topic XML File Description

Science.gov (United States)

... this page: https://medlineplus.gov/xmldescription.html Health Topic XML File Description: MedlinePlus To use the sharing ... information categories assigned. Example of a Full Health Topic Record A record for a MedlinePlus health topic ...

Summary record of the topical session of 16. Meeting of the IGSC

International Nuclear Information System (INIS)

Van Luik, Abe; Smith, Paul

2014-01-01

The sixteenth meeting of the Integration Group for the Safety case (IGSC) included a topical session titled: Handling extreme geological events in safety cases during the post-closure phase. The session included nine presentations on the handling of such events by various national programs, questions and answers on each presentation and ended with a general discussion period. The present document summarises the outcome of the meeting. The document is structured as follows: - Section 2 describes the types of extreme geological events discussed in the session and how these are identified, - Section 3 discusses the measures that can be taken to avoid such events and to mitigate their impact on repositories, - Section 4 describes how the likelihood and consequences of events are assessed, - Section 5 address experiences regarding interactions with regulators and other stakeholders, - Section 6 covers remaining issues and planned R and D to address these, and - Section 7 presents a recommendation for possible future collaborative work on this topic

Medical support of children’s sports: Topical problems

Directory of Open Access Journals (Sweden)

L. A. Balykova

2017-01-01

Full Text Available The paper discusses the most topical issues of medical support of children and adolescents engaged in physical exercises and sports. Much attention is paid to different views on the etiology, pathogenesis, diagnosis, and principles of therapy of pathological transformation of the heart in child athletes. The problem of sudden cardiac death in sports and the possibility of a relationship between connective tissue dysplasia and its development are touched upon. Electrocardiographic and morphological criteria for cardiac maladaptation in athletes are discussed. The problem of early and accessible diagnosis and Russia’s tactics for the diagnosis of health changes in athletes and approaches to their prevention and treatment are covered. Different ways to prevent the pathological transformation of the cardiovascular system in athletes and sudden cardiac death as its extreme manifestation are discussed.

Land Cover - Minnesota Land Cover Classification System

Data.gov (United States)

Minnesota Department of Natural Resources — Land cover data set based on the Minnesota Land Cover Classification System (MLCCS) coding scheme. This data was produced using a combination of aerial photograph...

The human heart and the circulatory system as an interesting interdisciplinary topic in lessons of physics and biology

International Nuclear Information System (INIS)

Volná, M; Látal, F; Kubínek, R; Richterek, L

2014-01-01

Many topics which are closely related can be found in the national curriculum of the Czech Republic for physics and biology. One of them is the heart and the circulatory system in the human body. This topic was examined cross curriculum, a teaching module was created and the topic was chosen for our research. The task was to determine if the students of bachelor study are aware of connections between physics and biology within this topic and whether we can help them effectively to describe the corresponding physics phenomena in the human body connected, for example, with a heart attack or with the measurement of blood pressure. In this paper, the heart and the circulatory system are presented as suitable topics for an interdisciplinary teaching module which includes both theoretical and experimental parts. The module was evaluated by a group of first-year undergraduate students of physics at the Faculty of Science, Palacký University. The acquired knowledge was compared with another control group through a test. The highest efficiency of the module was evaluated on the basis of questions that covered the calculation problems. (paper)

Identifying Topics in Microblogs Using Wikipedia.

Science.gov (United States)

Yıldırım, Ahmet; Üsküdarlı, Suzan; Özgür, Arzucan

2016-01-01

Twitter is an extremely high volume platform for user generated contributions regarding any topic. The wealth of content created at real-time in massive quantities calls for automated approaches to identify the topics of the contributions. Such topics can be utilized in numerous ways, such as public opinion mining, marketing, entertainment, and disaster management. Towards this end, approaches to relate single or partial posts to knowledge base items have been proposed. However, in microblogging systems like Twitter, topics emerge from the culmination of a large number of contributions. Therefore, identifying topics based on collections of posts, where individual posts contribute to some aspect of the greater topic is necessary. Models, such as Latent Dirichlet Allocation (LDA), propose algorithms for relating collections of posts to sets of keywords that represent underlying topics. In these approaches, figuring out what the specific topic(s) the keyword sets represent remains as a separate task. Another issue in topic detection is the scope, which is often limited to specific domain, such as health. This work proposes an approach for identifying domain-independent specific topics related to sets of posts. In this approach, individual posts are processed and then aggregated to identify key tokens, which are then mapped to specific topics. Wikipedia article titles are selected to represent topics, since they are up to date, user-generated, sophisticated articles that span topics of human interest. This paper describes the proposed approach, a prototype implementation, and a case study based on data gathered during the heavily contributed periods corresponding to the four US election debates in 2012. The manually evaluated results (0.96 precision) and other observations from the study are discussed in detail.

Recent Topical Research on Global, Energy, Health & Medical, and Tourism Economics, and Global Software

OpenAIRE

Chang, Chia-Lin; McAleer, Michael

2017-01-01

textabstractThe paper presents an overview of recent topical research on global, energy, health & medical, and tourism economics, and global software. We have interpreted “global” in the title of the Journal of Reviews on Global Economics to cover contributions that have a global impact on economics, thereby making it “global economics”. In this sense, the paper is concerned with papers on global, energy, health & medical, and tourism economics, as well as global software algorithms that have...

Regulatory Information By Topic

Science.gov (United States)

EPA develops and enforces regulations that span many environmental topics, from acid rain reduction to wetlands restoration. Each topic listed below may include related laws and regulations, compliance enforcement information, policies guidance

Identifying Topics in Microblogs Using Wikipedia.

Directory of Open Access Journals (Sweden)

Ahmet Yıldırım

Full Text Available Twitter is an extremely high volume platform for user generated contributions regarding any topic. The wealth of content created at real-time in massive quantities calls for automated approaches to identify the topics of the contributions. Such topics can be utilized in numerous ways, such as public opinion mining, marketing, entertainment, and disaster management. Towards this end, approaches to relate single or partial posts to knowledge base items have been proposed. However, in microblogging systems like Twitter, topics emerge from the culmination of a large number of contributions. Therefore, identifying topics based on collections of posts, where individual posts contribute to some aspect of the greater topic is necessary. Models, such as Latent Dirichlet Allocation (LDA, propose algorithms for relating collections of posts to sets of keywords that represent underlying topics. In these approaches, figuring out what the specific topic(s the keyword sets represent remains as a separate task. Another issue in topic detection is the scope, which is often limited to specific domain, such as health. This work proposes an approach for identifying domain-independent specific topics related to sets of posts. In this approach, individual posts are processed and then aggregated to identify key tokens, which are then mapped to specific topics. Wikipedia article titles are selected to represent topics, since they are up to date, user-generated, sophisticated articles that span topics of human interest. This paper describes the proposed approach, a prototype implementation, and a case study based on data gathered during the heavily contributed periods corresponding to the four US election debates in 2012. The manually evaluated results (0.96 precision and other observations from the study are discussed in detail.

Differential Topic Models.

Science.gov (United States)

Chen, Changyou; Buntine, Wray; Ding, Nan; Xie, Lexing; Du, Lan

2015-02-01

In applications we may want to compare different document collections: they could have shared content but also different and unique aspects in particular collections. This task has been called comparative text mining or cross-collection modeling. We present a differential topic model for this application that models both topic differences and similarities. For this we use hierarchical Bayesian nonparametric models. Moreover, we found it was important to properly model power-law phenomena in topic-word distributions and thus we used the full Pitman-Yor process rather than just a Dirichlet process. Furthermore, we propose the transformed Pitman-Yor process (TPYP) to incorporate prior knowledge such as vocabulary variations in different collections into the model. To deal with the non-conjugate issue between model prior and likelihood in the TPYP, we thus propose an efficient sampling algorithm using a data augmentation technique based on the multinomial theorem. Experimental results show the model discovers interesting aspects of different collections. We also show the proposed MCMC based algorithm achieves a dramatically reduced test perplexity compared to some existing topic models. Finally, we show our model outperforms the state-of-the-art for document classification/ideology prediction on a number of text collections.

Topic Model for Graph Mining.

Science.gov (United States)

Xuan, Junyu; Lu, Jie; Zhang, Guangquan; Luo, Xiangfeng

2015-12-01

Graph mining has been a popular research area because of its numerous application scenarios. Many unstructured and structured data can be represented as graphs, such as, documents, chemical molecular structures, and images. However, an issue in relation to current research on graphs is that they cannot adequately discover the topics hidden in graph-structured data which can be beneficial for both the unsupervised learning and supervised learning of the graphs. Although topic models have proved to be very successful in discovering latent topics, the standard topic models cannot be directly applied to graph-structured data due to the "bag-of-word" assumption. In this paper, an innovative graph topic model (GTM) is proposed to address this issue, which uses Bernoulli distributions to model the edges between nodes in a graph. It can, therefore, make the edges in a graph contribute to latent topic discovery and further improve the accuracy of the supervised and unsupervised learning of graphs. The experimental results on two different types of graph datasets show that the proposed GTM outperforms the latent Dirichlet allocation on classification by using the unveiled topics of these two models to represent graphs.

Analyses of Research Topics in the Field of Informetrics Based on the Method of Topic Modeling

OpenAIRE

Sung-Chien Lin

2014-01-01

In this study, we used the approach of topic modeling to uncover the possible structure of research topics in the field of Informetrics, to explore the distribution of the topics over years, and to compare the core journals. In order to infer the structure of the topics in the field, the data of the papers published in the Journal of Informetricsand Scientometrics during 2007 to 2013 are retrieved from the database of the Web of Science as input of the approach of topic modeling. The results ...

Analyses of Research Topics in the Field of Informetrics Based on the Method of Topic Modeling

Directory of Open Access Journals (Sweden)

Sung-Chien Lin

2014-07-01

Full Text Available In this study, we used the approach of topic modeling to uncover the possible structure of research topics in the field of Informetrics, to explore the distribution of the topics over years, and to compare the core journals. In order to infer the structure of the topics in the field, the data of the papers published in the Journal of Informetricsand Scientometrics during 2007 to 2013 are retrieved from the database of the Web of Science as input of the approach of topic modeling. The results of this study show that when the number of topics was set to 10, the topic model has the smallest perplexity. Although data scopes and analysis methodsare different to previous studies, the generating topics of this study are consistent with those results produced by analyses of experts. Empirical case studies and measurements of bibliometric indicators were concerned important in every year during the whole analytic period, and the field was increasing stability. Both the two core journals broadly paid more attention to all of the topics in the field of Informetrics. The Journal of Informetricsput particular emphasis on construction and applications ofbibliometric indicators and Scientometrics focused on the evaluation and the factors of productivity of countries, institutions, domains, and journals.

Topical treatments of skin pain: a general review with a focus on hidradenitis suppurativa with topical agents.

Science.gov (United States)

Scheinfeld, Noah

2014-07-15

Hidradenitis Supprurativa (HS) is a painful chronic follicular disease. Few papers have addressed pain control for this debilitating condition. Possible topical agents include tricyclic antidepressants, opioids, anticonvulsants, NSAIDs, NMDA receptor antagonists, local anesthetics and other agents. The first line agents for the topical treatment of the cutaneous pain of HS are diclonefac gel 1% and liposomal xylocaine 4% and 5% cream or 5% ointment. The chief advantage of topical xylocaine is that is quick acting i.e. immediate however with a limited duration of effect 1-2 hours. The use of topical ketamine, which blocks n-methyl-D-aspartate receptors in a non-competitive fashion, might be a useful tool for the treatment of HS pain. Topical doxepin, which available in a 5% commercially preparation (Zonalon®) , makes patients drowsy and is not useful for controlling the pain of HS . Doxepin is available in a 3% or 3.3% concentration (which causes less drowsiness) from compounding pharmacies and can be used in compounded analgesic preparations with positive effect. Topical doxepin is preferred over use of topical amitriptyline because topical doxepin is more effective. Nevertheless, topical amitriptyline increase of the tactile and mechanical nociceptive thresholds and can be used for topical pain control in compound mixture of analgesics . Gabapentin and pregablin can also be used compounded with other agents in topical analgesic preparations with positive topical anesthetic effect. Capsaicin is not useful for topical treatment of the pain of HS. Sometimes compounded of anesthetics medications such as ketamine 10%, bupivacaine 1%, diclofenac 3%, doxepin 3% or 3.3%, and gabapentin 6% can extend the duration of effect so that medication only needs to be used 2 or 3 times a day. Still in my experience the easiest to get and most patient requested agent is topical diclonefac 1% gel.

46{sup th} Annual meeting on nuclear technology (AMNT 2015). Key topics / Outstanding know-how and sustainable innovations / Enhanced safety and operation excellence

Energy Technology Data Exchange (ETDEWEB)

Schaffrath, Andreas; Scheuerer, Martina [Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH (GRS), Garching (Germany); Oenneby Carina; Benjaminsson, Ulf [Westinghouse Electric Sweden AB, Vaesteraes (Sweden). Europe, Middle East and Africa (EMEA)

2015-11-15

Summary report on the Topical Sessions ''CFD Simulations for Reactor Safety Relevant Objectives '' and ''Fuel Management During the Last Cycles and Beyond'' of the 46th Annual Conference on Nuclear Technology (AMNT 2015) held in Berlin, 5 to 7 May 2015. Other Sessions of AMNT 2015 have been covered in atw 7 to 10 (2015) and will be covered in further issues of atw.

Topical steroid-damaged skin

Directory of Open Access Journals (Sweden)

Anil Abraham

2014-01-01

Full Text Available Topical steroids, commonly used for a wide range of skin disorders, are associated with side effects both systemic and cutaneous. This article aims at bringing awareness among practitioners, about the cutaneous side effects of easily available, over the counter, topical steroids. This makes it important for us as dermatologists to weigh the usefulness of topical steroids versus their side effects, and to make an informed decision regarding their use in each individual based on other factors such as age, site involved and type of skin disorder.

Mental Mechanisms for Topics Identification

Directory of Open Access Journals (Sweden)

Louis Massey

2014-01-01

Full Text Available Topics identification (TI is the process that consists in determining the main themes present in natural language documents. The current TI modeling paradigm aims at acquiring semantic information from statistic properties of large text datasets. We investigate the mental mechanisms responsible for the identification of topics in a single document given existing knowledge. Our main hypothesis is that topics are the result of accumulated neural activation of loosely organized information stored in long-term memory (LTM. We experimentally tested our hypothesis with a computational model that simulates LTM activation. The model assumes activation decay as an unavoidable phenomenon originating from the bioelectric nature of neural systems. Since decay should negatively affect the quality of topics, the model predicts the presence of short-term memory (STM to keep the focus of attention on a few words, with the expected outcome of restoring quality to a baseline level. Our experiments measured topics quality of over 300 documents with various decay rates and STM capacity. Our results showed that accumulated activation of loosely organized information was an effective mental computational commodity to identify topics. It was furthermore confirmed that rapid decay is detrimental to topics quality but that limited capacity STM restores quality to a baseline level, even exceeding it slightly.

KEY TOPICS IN SPORTS MEDICINE

Directory of Open Access Journals (Sweden)

Amir Ali Narvani

2006-12-01

Full Text Available Key Topics in Sports Medicine is a single quick reference source for sports and exercise medicine. It presents the essential information from across relevant topic areas, and includes both the core and emerging issues in this rapidly developing field. It covers: 1 Sports injuries, rehabilitation and injury prevention, 2 Exercise physiology, fitness testing and training, 3 Drugs in sport, 4 Exercise and health promotion, 5 Sport and exercise for special and clinical populations, 6 The psychology of performance and injury. PURPOSE The Key Topics format provides extensive, concise information in an accessible, easy-to-follow manner. AUDIENCE The book is targeted the students and specialists in sports medicine and rehabilitation, athletic training, physiotherapy and orthopaedic surgery. The editors are authorities in their respective fields and this handbook depends on their extensive experience and knowledge accumulated over the years. FEATURES The book contains the information for clinical guidance, rapid access to concise details and facts. It is composed of 99 topics which present the information in an order that is considered logical and progressive as in most texts. Chapter headings are: 1. Functional Anatomy, 2. Training Principles / Development of Strength and Power, 3. Biomechanical Principles, 4. Biomechanical Analysis, 5. Physiology of Training, 6. Monitoring of Training Progress, 7. Nutrition, 8. Hot and Cold Climates, 9. Altitude, 10. Sport and Travelling, 11. Principles of Sport Injury Diagnosis, 12. Principles of Sport and Soft Tissue Management, 13. Principles of Physical Therapy and Rehabilitation, 14. Principles of Sport Injury Prevention, 15. Sports Psychology, 16. Team Sports, 17. Psychological Aspects of Injury in Sport, 18. Injury Repair Process, 19. Basic Biomechanics of Tissue Injury, 20. Plain Film Radiography in Sport, 21. Nuclear Medicine, 22. Diagnostic Ultrasound, 23. MRI Scan, 24. Other Imaging, 5. Head Injury, 26. Eye

Topical Treatment of Degenerative Knee Osteoarthritis.

Science.gov (United States)

Meng, Zengdong; Huang, Rongzhong

2018-01-01

This article reviews topical management strategies for degenerative osteoarthritis (OA) of the knee. A search of Pubmed, Embase and the Cochrane library using MeSH terms including "topical," "treatment," "knee" and "osteoarthritis" was carried out. Original research and review articles on the effectiveness and safety, recommendations from international published guidelines and acceptability studies of topical preparations were included. Current topical treatments included for the management of knee OA include topical nonsteroidal anti-inflammatory drugs, capsaicin, salicylates and physical treatments such as hot or cold therapy. Current treatment guidelines recommend topical nonsteroidal anti-inflammatory drugs as an alternative and even first-line therapy for OA management, especially among elderly patients. Guidelines on other topical treatments vary, from recommendations against their use, to in favor as alternative or simultaneous therapy, especially for patients with contraindications to other analgesics. Although often well-tolerated and preferred by many patients, clinical care still lags in the adoption of topical treatments. Aspects of efficacy, safety and patient quality of life data require further research. Copyright © 2018 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

Correlated Topic Vector for Scene Classification.

Science.gov (United States)

Wei, Pengxu; Qin, Fei; Wan, Fang; Zhu, Yi; Jiao, Jianbin; Ye, Qixiang

2017-07-01

Scene images usually involve semantic correlations, particularly when considering large-scale image data sets. This paper proposes a novel generative image representation, correlated topic vector, to model such semantic correlations. Oriented from the correlated topic model, correlated topic vector intends to naturally utilize the correlations among topics, which are seldom considered in the conventional feature encoding, e.g., Fisher vector, but do exist in scene images. It is expected that the involvement of correlations can increase the discriminative capability of the learned generative model and consequently improve the recognition accuracy. Incorporated with the Fisher kernel method, correlated topic vector inherits the advantages of Fisher vector. The contributions to the topics of visual words have been further employed by incorporating the Fisher kernel framework to indicate the differences among scenes. Combined with the deep convolutional neural network (CNN) features and Gibbs sampling solution, correlated topic vector shows great potential when processing large-scale and complex scene image data sets. Experiments on two scene image data sets demonstrate that correlated topic vector improves significantly the deep CNN features, and outperforms existing Fisher kernel-based features.

Topical treatment of psoriasis: questionnaire results on topical therapy accessibility and influence of body surface area on usage.

Science.gov (United States)

Iversen, L; Lange, M M; Bissonette, R; Carvalho, A V E; van de Kerkhof, P C; Kirby, B; Kleyn, C E; Lynde, C W; van der Walt, J M; Wu, J J

2017-07-01

Topical treatment of mild to moderate psoriasis is first-line treatment and exhibits varying degrees of success across patient groups. Key factors influencing treatment success are physician topical treatment choice (high efficacy, low adverse events) and strict patient adherence. Currently, no formalized, international consensus guidelines exist to direct optimal topical treatment, although many countries have national guidelines. To describe and analyse cross-regional variations in the use and access of psoriasis topical therapies. The study was conducted as an observational cross-sectional study. A survey was distributed to dermatologists from the International Psoriasis Council (IPC) to assess topical therapy accessibility in 26 countries and to understand how body surface area (BSA) categories guide clinical decisions on topical use. Variation in the availability of tars, topical retinoids, dithranol and balneotherapy was reported. The vast majority of respondents (100% and 88.4%) used topical therapy as first-line monotherapy in situations with BSA 10%, the number of respondents who prescribe topical therapy decreased considerably. In addition, combination therapy of a topical drug and a systemic drug was frequently reported when BSA measured >10%. This physician survey provides new evidence on topical access and the influence of disease severity on topical usage in an effort to improve treatment strategies on a global level. © 2017 European Academy of Dermatology and Venereology.

Assessment of land cover changes in Lampedusa Island (Italy) using Landsat TM and OLI data

Science.gov (United States)

Mei, Alessandro; Manzo, Ciro; Fontinovo, Giuliano; Bassani, Cristiana; Allegrini, Alessia; Petracchini, Francesco

2016-10-01

The Lampedusa Island displays important socio-economic criticalities related to an intensive touristic activity, which implies an increase in electricity consumption and waste production. An adequate island conversion to a more environmental, sustainable community needs to be faced by the local Management Plans establishment. For this purpose, several thematic datasets have to be produced and evaluated. Socio-economic and bio-ecological components as well as land cover/use assessment are some of the main topics to be managed within the Decision Support Systems. Considering the lack of Land Cover (LC) and vegetation change detection maps in Lampedusa Island (Italy), this paper focuses on the retrieval of these topics by remote sensing techniques. The analysis was carried out by Landsat 5 TM and Landsat 8 OLI multispectral images from 1984 to 2014 in order to obtain spatial and temporal information of changes occurred in the island. Firstly, imagery was co-registered and atmospherically corrected; secondly, it was then classified for land cover and vegetation distribution analysis with the use of QGIS and Saga GIS open source softwares. The Maximum Likelihood Classifier (MLC) was used for LC maps production, while the Normalized Difference Vegetation Index (NDVI) was used for vegetation examination and distribution. Topographic maps, historical aerial photos, ortophotos and field data are merged in the GIS for accuracy assessment. Finally, change detection of MLC and NDVI are provided respectively by Post-Classification Comparison (PCC) and Image Differencing (ID). The provided information, combined with local socio-economic parameters, is essential for the improvement of environmental sustainability of anthropogenic activities in Lampedusa.

Topics in quantum groups and finite-type invariants mathematics at the independent University of Moscow

CERN Document Server

Arkhipov, S M; Odesskii, A V; Feigin, B; Vassiliev, V

1998-01-01

This volume presents the first collection of articles consisting entirely of work by faculty and students of the Higher Mathematics College of the Independent University of Moscow (IUM). This unique institution was established to train elite students to become research scientists. Covered in the book are two main topics: quantum groups and low-dimensional topology. The articles were written by participants of the Feigin and Vassiliev seminars, two of the most active seminars at the IUM.

47{sup th} Annual meeting on nuclear technology (AMNT 2016). Key topic / Outstanding know-how and sustainable innovations

Energy Technology Data Exchange (ETDEWEB)

Zwermann, Winfried [Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) gGmbH, Garching (Germany). Forschungszentrum

2016-11-15

Summary report on the Key Topic ''Outstanding Know-How and Sustainable Innovations'' Technical Session ''Reactor Physics, Thermo, and Fluid Dynamics'' of the 47th Annual Conference on Nuclear Technology (AMNT 2016) held in Hamburg, 10 to 12 May 2016. Other Sessions of AMNT 2016 have been and will be covered in further issues of atw.

National Land Cover Database (NLCD) Land Cover Collection

Data.gov (United States)

U.S. Geological Survey, Department of the Interior — The National Land Cover Database (NLCD) Land Cover Collection is produced through a cooperative project conducted by the Multi-Resolution Land Characteristics (MRLC)...

Topical botulinum toxin.

Science.gov (United States)

Collins, Ashley; Nasir, Adnan

2010-03-01

Nanotechnology is a rapidly growing discipline that capitalizes on the unique properties of matter engineered on the nanoscale. Vehicles incorporating nanotechnology have led to great strides in drug delivery, allowing for increased active ingredient stability, bioavailability, and site-specific targeting. Botulinum toxin has historically been used for the correction of neurological and neuromuscular disorders, such as torticollis, blepharospasm, and strabismus. Recent dermatological indications have been for the management of axillary hyperhydrosis and facial rhytides. Traditional methods of botulinum toxin delivery have been needle-based. These have been associated with increased pain and cost. Newer methods of botulinum toxin formulation have yielded topical preparations that are bioactive in small pilot clinical studies. While there are some risks associated with topical delivery, the refinement and standardization of delivery systems and techniques for the topical administration of botulinum toxin using nanotechnology is anticipated in the near future.

Statistical evaluation of diagnostic performance topics in ROC analysis

CERN Document Server

Zou, Kelly H; Bandos, Andriy I; Ohno-Machado, Lucila; Rockette, Howard E

2016-01-01

Statistical evaluation of diagnostic performance in general and Receiver Operating Characteristic (ROC) analysis in particular are important for assessing the performance of medical tests and statistical classifiers, as well as for evaluating predictive models or algorithms. This book presents innovative approaches in ROC analysis, which are relevant to a wide variety of applications, including medical imaging, cancer research, epidemiology, and bioinformatics. Statistical Evaluation of Diagnostic Performance: Topics in ROC Analysis covers areas including monotone-transformation techniques in parametric ROC analysis, ROC methods for combined and pooled biomarkers, Bayesian hierarchical transformation models, sequential designs and inferences in the ROC setting, predictive modeling, multireader ROC analysis, and free-response ROC (FROC) methodology. The book is suitable for graduate-level students and researchers in statistics, biostatistics, epidemiology, public health, biomedical engineering, radiology, medi...

Topical methotrexate pretreatment enhances the therapeutic effect of topical 5-aminolevulinic acid-mediated photodynamic therapy on hamster buccal pouch precancers.

Science.gov (United States)

Yang, Deng-Fu; Lee, Jeng-Woei; Chen, Hsin-Ming; Hsu, Yih-Chih

2014-09-01

Topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is effective for treatment of human oral precancerous lesions. This animal study aimed to assess whether topical methotrexate (MTX) pretreatment could enhance the therapeutic effect of topical ALA-PDT on hamster buccal pouch precancerous lesions. Twenty hamster buccal pouch precancerous lesions were treated with either topical ALA-PDT with topical MTX pretreatment (topical MTX-ALA-PDT group, n = 10) or topical ALA-PDT alone (topical ALA-PDT group, n = 10). The intracellular protoporphyrin IX (PpIX) level in another 12 precancerous lesions (n = 6 for either the topical MTX-ALA or topical ALA group) was monitored by fluorescence spectroscopy. The intracellular PpIX reached its peak level in precancerous lesions 6.5 hours and 2.5 hours after topical ALA application for the topical MTX-ALA group (5.63-fold higher in the lesion than in the normal mucosa) and topical ALA group (2.42-fold higher in the lesion than in the normal mucosa), respectively. The complete response rate of precancerous lesions was 80% for the topical MTX-ALA-PDT group and 70% for the topical ALA-PDT group. In addition, the topical MTX-ALA-PDT group required a significantly lower mean treatment number (2.1 ± 0.6) to achieve complete response than the topical ALA-PDT group (4.4 ± 1.3, p topical MTX-ALA-PDT group had a lower recurrence rate (12.5%) than the topical ALA-PDT group (28.6%). We conclude that topical MTX-pretreatment can increase intracellular PpIX production in hamster buccal pouch precancerous lesions and significantly improves the outcomes of the precancerous lesions treated with topical ALA-PDT. Copyright © 2014. Published by Elsevier B.V.

LAFD: TA-55 General Facility Familiarization Tour, Course #55261

Energy Technology Data Exchange (ETDEWEB)

Rutherford, Victor Stephen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Miller, Joshua [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Mason, Robert Clifford [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2018-01-10

Los Alamos National Laboratory (LANL) will conduct familiarization tours for personnel of the Los Alamos County Fire Department (LAFD) at the TA-55 General Facility. These familiarization tours are official LANL business; the purpose of these tours is to orient LAFD firefighters to the facility so that they can respond efficiently and quickly to a variety of emergency situations. This orientation includes, among other topics, ingress and egress of the area and buildings, layout and organization of the facility, evacuation procedures and assembly points, and areas of concern within the various buildings at the facility. LAFD firefighters have the skills and abilities to perform firefighting operations and other emergency response tasks that cannot be provided by LANL personnel who have the required clearance level. This handout provides details of the information, along with maps and diagrams, to be presented during the familiarization tours. The handout will be distributed to the trainees at the time of the tour. A corresponding checklist will also be used as guidance during the familiarization tours to ensure that all required information is presented to LAFD personnel.

LAFD: TA-16 HE Facility Familiarization Tour, OJT 55258

Energy Technology Data Exchange (ETDEWEB)

Rutherford, Victor Stephen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-05-31

Los Alamos National Laboratory (LANL) will conduct familiarization tours for personnel of the Los Alamos County Fire Department (LAFD) at TA-16 high explosives (HE) facilities. These familiarization tours are official LANL business; the purpose of these tours is to orient LAFD firefighters to the facility so that they can respond efficiently and quickly to a variety of emergency situations. This orientation includes, among other topics, ingress and egress of the area and buildings, layout and organization of the facility, evacuation procedures and assembly points, and areas of concern within the various buildings at the facility. LAFD firefighters have the skills and abilities to perform firefighting operations and other emergency response tasks that cannot be provided by LANL personnel who have the required clearance. This handout provides details of the information, along with maps and diagrams, to be presented during the familiarization tours. The handout will be distributed to the trainees at the time of the tour. A corresponding checklist will also be used as guidance during the familiarization tours to ensure that all required information is presented to LAFD personnel.

Documenting and predicting topic changes in Computers in Biology and Medicine: A bibliometric keyword analysis from 1990 to 2017

Directory of Open Access Journals (Sweden)

Oliver Faust

Full Text Available The Computers in Biology and Medicine (CBM journal promotes the use of computing machinery in the fields of bioscience and medicine. Since the first volume in 1970, the importance of computers in these fields has grown dramatically, this is evident in the diversification of topics and an increase in the publication rate. In this study, we quantify both change and diversification of topics covered in. This is done by analysing the author supplied keywords, since they were electronically captured in 1990. The analysis starts by selecting 40 keywords, related to Medical (M (7, Data (D (10, Feature (F (17 and (AI (6 methods. Automated keyword clustering shows the statistical connection between the selected keywords. We found that the three most popular topics in CBM are: Support Vector Machine (SVM, Electroencephalography (EEG and IMAGE PROCESSING. In a separate analysis step, we bagged the selected keywords into sequential one year time slices and calculated the normalized appearance. The results were visualised with graphs that indicate the CBM topic changes. These graphs show that there was a transition from Artificial Neural Network (ANN to SVM. In 2006 SVM replaced ANN as the most important AI algorithm. Our investigation helps the editorial board to manage and embrace topic change. Furthermore, our analysis is interesting for the general reader, as the results can help them to adjust their research directions. Keywords: Research trends, Topic analysis, Topic detection and tracking, Text mining, Computers in biology and medicine

Dermal carotenoid level and kinetics after topical and systemic administration of antioxidants: enrichment strategies in a controlled in vivo study.

Science.gov (United States)

Darvin, Maxim E; Fluhr, Joachim W; Schanzer, Sabine; Richter, Heike; Patzelt, Alexa; Meinke, Martina C; Zastrow, Leonhard; Golz, Karin; Doucet, Olivier; Sterry, Wolfram; Lademann, Juergen

2011-10-01

High doses of sun-emitted UV-radiation induce reactive oxygen species (ROS) as major pro-oxidants thus inducing premature skin aging. The best prevention of the destructive action of free radicals in human skin is textile coverings, topical sunscreens and the development of a high antioxidative protective network. The effects of topical, systemic and combined application of antioxidants (AO) were investigated on human skin in vivo. Topical application of creams and systemic incorporation of tablets both containing AO was investigated in vivo by resonance Raman spectroscopy. Topical, systemic and combined AO-treatments induced a statistically significant increase of AO levels in human skin while placebo did not show any changes. The highest accumulation was induced by the combination of topical and systemic AO. Carotenoid-tablets combined with placebo-cream induced less carotenoid accumulation than carotenoid-tablets alone. Carotenoid levelling after the end of treatment lasted for around 2 weeks following the topical application of AOs, and up to 5 weeks after systemic administration, depending on the BMI of volunteers. Topically applied AO are stored in the SC for a short time only due to the rapid AO-depletion by desquamation, textile contact, washing and environmental stress. In contrast to topical application, the systemically applied carotenoids are stored in the body fat tissue and slowly released onto the skin surface with sweat and sebum. The combined topical and systemic application of AO represents an optimal form of protection of the AO-network. Copyright © 2011 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.

What’s all the talk about? Topic modelling in a mental health Internet support group

Directory of Open Access Journals (Sweden)

Bradley Carron-Arthur

2016-10-01

Full Text Available Abstract Background The majority of content in an Internet Support Group (ISG is contributed by 1 % of the users (‘super users’. Computational methods, such as topic modelling, can provide a large-scale quantitative objective description of this content. Such methods may provide a new perspective on the nature of engagement on ISGs including the role of super users and their possible effect on other users. Methods A topic model was computed for all posts (N = 131,004 in the ISG BlueBoard using Latent Dirichlet Allocation. A model containing 25 topics was selected on the basis of intelligibility as determined by diagnostic metrics and qualitative investigation. This model yielded 21 substantive topics for further analysis. Two chi-square tests were conducted separately for each topic to ascertain: (i if the odds of super users’ and other users’ posting differed for each topic; and (ii if for super users the odds of posting differed depending on whether the response was to a super user or to another user. Results The 21 substantive topics covered a range of issues related to mental health and peer-support. There were significantly higher odds that super users wrote content on 13 topics, with the greatest effects being for Parenting Role (OR [95%CI] = 7.97 [7.85–8.10], Co-created Fiction (4.22 [4.17–4.27], Mental Illness (3.13 [3.11–3.16] and Positive Change (2.82 [2.79–2.84]. There were significantly lower odds for super users on 7 topics, with the greatest effects being for the topics Depression (OR = 0.27 [0.27–0.28], Medication (0.36 [0.36–0.37], Therapy (0.55 [0.54–0.55] and Anxiety (0.55 [0.55–0.55]. However, super users were significantly more likely to write content on 5 out of these 7 topics when responding to other users than when responding to fellow super users. Conclusions The findings suggest that super users serve the role of emotionally supportive companions with a focus on topics broadly

Recent advances in topical anesthesia

Science.gov (United States)

2016-01-01

Topical anesthetics act on the peripheral nerves and reduce the sensation of pain at the site of application. In dentistry, they are used to control local pain caused by needling, placement of orthodontic bands, the vomiting reflex, oral mucositis, and rubber-dam clamp placement. Traditional topical anesthetics contain lidocaine or benzocaine as active ingredients and are used in the form of solutions, creams, gels, and sprays. Eutectic mixtures of local anesthesia cream, a mixture of various topical anesthetics, has been reported to be more potent than other anesthetics. Recently, new products with modified ingredients and application methods have been introduced into the market. These products may be used for mild pain during periodontal treatment, such as scaling. Dentists should be aware that topical anesthetics, although rare, might induce allergic reactions or side effects as a result of an overdose. Topical anesthetics are useful aids during dental treatment, as they reduce dental phobia, especially in children, by mitigating discomfort and pain. PMID:28879311

Discriminative Relational Topic Models.

Science.gov (United States)

Chen, Ning; Zhu, Jun; Xia, Fei; Zhang, Bo

2015-05-01

Relational topic models (RTMs) provide a probabilistic generative process to describe both the link structure and document contents for document networks, and they have shown promise on predicting network structures and discovering latent topic representations. However, existing RTMs have limitations in both the restricted model expressiveness and incapability of dealing with imbalanced network data. To expand the scope and improve the inference accuracy of RTMs, this paper presents three extensions: 1) unlike the common link likelihood with a diagonal weight matrix that allows the-same-topic interactions only, we generalize it to use a full weight matrix that captures all pairwise topic interactions and is applicable to asymmetric networks; 2) instead of doing standard Bayesian inference, we perform regularized Bayesian inference (RegBayes) with a regularization parameter to deal with the imbalanced link structure issue in real networks and improve the discriminative ability of learned latent representations; and 3) instead of doing variational approximation with strict mean-field assumptions, we present collapsed Gibbs sampling algorithms for the generalized relational topic models by exploring data augmentation without making restricting assumptions. Under the generic RegBayes framework, we carefully investigate two popular discriminative loss functions, namely, the logistic log-loss and the max-margin hinge loss. Experimental results on several real network datasets demonstrate the significance of these extensions on improving prediction performance.

Topical anesthesia

Directory of Open Access Journals (Sweden)

Mritunjay Kumar

2015-01-01

Full Text Available Topical anesthetics are being widely used in numerous medical and surgical sub-specialties such as anesthesia, ophthalmology, otorhinolaryngology, dentistry, urology, and aesthetic surgery. They cause superficial loss of pain sensation after direct application. Their delivery and effectiveness can be enhanced by using free bases; by increasing the drug concentration, lowering the melting point; by using physical and chemical permeation enhancers and lipid delivery vesicles. Various topical anesthetic agents available for use are eutectic mixture of local anesthetics, ELA-max, lidocaine, epinephrine, tetracaine, bupivanor, 4% tetracaine, benzocaine, proparacaine, Betacaine-LA, topicaine, lidoderm, S-caine patch™ and local anesthetic peel. While using them, careful attention must be paid to their pharmacology, area and duration of application, age and weight of the patients and possible side-effects.

Proceedings of the topical meeting on reactivity initiated accidents (RIA)

International Nuclear Information System (INIS)

2003-01-01

The topical meeting was devoted to RIA fuel acceptance criteria, in particular to the fuel fragmentation enthalpy limit and the PCMI failure enthalpy limit in relation to high burnup fuel. In total 50 participants attended. Research and industry organisations from France, Finland, Germany, Hungary, Japan, the Russian Federation, Sweden, the United Kingdom and the USA including the Swiss regulatory body, HSK, and the Halden reactor project, presented 16 papers in all. The papers covered three main areas: 'best estimate' core calculations for RIA energy deposition in high burnup fuels, the technical background of current and new RIA fuel safety criteria, and ongoing RIA experimental programmes. A number of open issues were identified, whose resolution is expected from ongoing and planned national and international experimental programmes

Problematic topic transitions in dysarthric conversation.

Science.gov (United States)

Bloch, Steven; Saldert, Charlotta; Ferm, Ulrika

2015-01-01

This study examined the nature of topic transition problems associated with acquired progressive dysarthric speech in the everyday conversation of people with motor neurone disease. Using conversation analytic methods, a video collection of five naturally occurring problematic topic transitions was identified, transcribed and analysed. These were extracted from a main collection of over 200 other-initiated repair sequences and a sub-set of 15 problematic topic transition sequences. The sequences were analysed with reference to how the participants both identified and resolved the problems. Analysis revealed that topic transition by people with dysarthria can prove problematic. Conversation partners may find transitions problematic not only because of speech intelligibility but also because of a sequential disjuncture between the dysarthric speech turn and whatever topic has come prior. In addition the treatment of problematic topic transition as a complaint reveals the potential vulnerability of people with dysarthria to judgements of competence. These findings have implications for how dysarthria is conceptualized and how specific actions in conversation, such as topic transition, might be suitable targets for clinical intervention.

76 FR 81806 - Ophthalmic and Topical Dosage Form New Animal Drugs; Ivermectin Topical Solution

Science.gov (United States)

2011-12-29

.... FDA-2011-N-0003] Ophthalmic and Topical Dosage Form New Animal Drugs; Ivermectin Topical Solution... solution of ivermectin. DATES: This rule is effective December 29, 2011. FOR FURTHER INFORMATION CONTACT... ANADA 200-318 for [[Page 81807

Topical methotrexate pretreatment enhances the therapeutic effect of topical 5-aminolevulinic acid-mediated photodynamic therapy on hamster buccal pouch precancers

OpenAIRE

Deng-Fu Yang; Jeng-Woei Lee; Hsin-Ming Chen; Yih-Chih Hsu

2014-01-01

Topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is effective for treatment of human oral precancerous lesions. This animal study aimed to assess whether topical methotrexate (MTX) pretreatment could enhance the therapeutic effect of topical ALA-PDT on hamster buccal pouch precancerous lesions. Methods: Twenty hamster buccal pouch precancerous lesions were treated with either topical ALA-PDT with topical MTX pretreatment (topical MTX-ALA-PDT group, n = 10) or topical A...

11. international topical meeting on nuclear reactor thermal-hydraulics (NURETH-11)

International Nuclear Information System (INIS)

Lemonnier, H.

2005-01-01

The main topics covered by the NURETH 11 meeting are the thermal-hydraulics of existing and future nuclear power plants as foreseen by the Generation IV worldwide initiative. Normal operation and accidental situations are also relevant topics of the Conference. The topics cover modeling, experiments, instrumentation and numerical simulations related to flow and heat transfer in nuclear reactors with a special emphasis on the advances of multiphase CFD methods. The first part of this Book of Abstracts enumerates the Organizing Scientific Societies, the Sponsors of the Conference, the Conference Chairs, and the members of the Steering Committee and of the Technical Program Committee. The second part of this Book of Abstracts contains the list of the titles of the contributed papers. Each item includes the log number of the paper, the abstract of which can therefore be easily located in the next section of this book. The titles of the papers have been sorted out by topics to provide a synthetic view of the contributions in a selected domain. The last section of this Book includes an index of authors and co-authors with a reference to the log number(s) of their contributed paper(s). Finally, the CD-Rom of the Conference Proceedings containing the full-length papers is inserted at the inside back cover. Sessions content: A - two-phase flow and heat transfer fundamentals: computational and mathematical techniques (numerical schemes, LBM, BEM, mesh-less, etc.); contact angle and wettability phenomena; experiments and data bases for the assessment and the verification of 3D models; flow regime identification and modelling; heat transfer near critical pressure and supercritical water reactors; interfacial area (data base, modeling, measurement techniques); instrumentation techniques; micro-scale basic phenomena, fluid flow and heat transfer; scaling methods; counter current flow; B - code developments: containment analysis; core thermal-hydraulics and subchannel analysis

Landfill Top Covers

DEFF Research Database (Denmark)

Scheutz, Charlotte; Kjeldsen, Peter

2011-01-01

The purpose of the final cover of a landfill is to contain the waste and to provide for a physical separation between the waste and the environment for protection of public health. Most landfill covers are designed with the primary goal to reduce or prevent infiltration of precipitation...... into the landfill in order to minimize leachate generation. In addition the cover also has to control the release of gases produced in the landfill so the gas can be ventilated, collected and utilized, or oxidized in situ. The landfill cover should also minimize erosion and support vegetation. Finally the cover...... is landscaped in order to fit into the surrounding area/environment or meet specific plans for the final use of the landfill. To fulfill the above listed requirements landfill covers are often multicomponent systems which are placed directly on top of the waste. The top cover may be placed immediately after...

Topical immunomodulators in dermatology

Directory of Open Access Journals (Sweden)

Khandpur Sujay

2004-04-01

Full Text Available Topical immunomodulators are agents that regulate the local immune response of the skin. They are now emerging as the therapy of choice for several immune-mediated dermatoses such as atopic dermatitis, contact allergic dermatitis, alopecia areata, psoriasis, vitiligo, connective tissue disorders such as morphea and lupus erythematosus, disorders of keratinization and several benign and malignant skin tumours, because of their comparable efficacy, ease of application and greater safety than their systemic counterparts. They can be used on a domiciliary basis for longer periods without aggressive monitoring. In this article, we have discussed the mechanism of action, common indications and side-effects of the commonly used topical immunomodulators, excluding topical steroids. Moreover, newer agents, which are still in the experimental stages, have also been described. A MEDLINE search was undertaken using the key words "topical immunomodulators, dermatology" and related articles were also searched. In addition, a manual search for many Indian articles, which are not indexed, was also carried out. Wherever possible, the full article was reviewed. If the full article could not be traced, the abstract was used.

Recent Advances In Topical Therapy In Dermatology

Directory of Open Access Journals (Sweden)

Mohan Thappa Devinder

2003-01-01

Full Text Available With changing times various newer topical agents are introduced in the field of dermatology. Tacrolimus and pimecrolimus are immunisuppressants, which are effective topically and are tried in the management of atopic dermatitis as well as other disorders including allergic contact dermatitis, atrophic lichen planus, pyoderma gangrenosum. Imiquimod, an immune response modifier, is presently in use for genital warts but has potentials as anti- tumour agent and in various other dermatological conditions when used topically. Tazarotene is a newer addition to the list of topical reginoids, which is effective in psoriasis and has better effect in combination with calcipotriene, phototherapy and topical costicosteroids. Tazarotene and adapelene are also effective in inflammatory acne. Calcipotriol, a vitamin D analogue has been introduced as a topical agent in the treatment of psoriasis. Steroid components are also developed recently which will be devoid of the side effects but having adequate anti-inflammatory effect. Topical photodynamic therapy has also a wide range of use in dermatology. Newer topical agents including cidofovir, capsaicin, topical sensitizers, topical antifungal agents for onychomycosis are also of use in clinical practice. Other promising developments include skin substitutes and growth factors for wound care.

Topical administration of orbital fat-derived stem cells promotes corneal tissue regeneration.

Science.gov (United States)

Lin, Ko-Jo; Loi, Mei-Xue; Lien, Gi-Shih; Cheng, Chieh-Feng; Pao, Hsiang-Yin; Chang, Yun-Chuang; Ji, Andrea Tung-Qian; Ho, Jennifer Hui-Chun

2013-06-14

Topical administration of eye drops is the major route for drug delivery to the cornea. Orbital fat-derived stem cells (OFSCs) possess an in vitro corneal epithelial differentiation capacity. Both the safety and immunomodulatory ability of systemic OFSC transplantation were demonstrated in our previous work. In this study, we investigated the safety, therapeutic effect, and mechanism(s) of topical OFSC administration in an extensive alkali-induced corneal wound. Corneal injury was created by contact of a piece of 0.5 N NaOH-containing filter paper on the corneal surface of a male Balb/c mouse for 30 s. The area of the filter paper covered the central 70% or 100% of the corneal surface. OFSCs (2 × 10(5)) in 5 μl phosphate-buffered saline (PBS) were given by topical administration (T) twice a day or by two intralimbal (IL) injections in the right cornea, while 5 μl of PBS in the left cornea served as the control. Topical OFSCs promoted corneal re-epithelialization of both the limbal-sparing and limbal-involved corneal wounds. In the first three days, topical OFSCs significantly reduced alkali-induced corneal edema and stromal infiltration according to a histopathological examination. Immunohistochemistry and immunofluorescence staining revealed that transplanted cells were easily detectable in the corneal epithelium, limbal epithelium and stroma, but only some of transplanted cells at the limbal epithelium had differentiated into cytokeratin 3-expressing cells. OFSCs did not alter neutrophil (Ly6G) levels in the cornea, but significantly reduced macrophage (CD68) infiltration and inducible nitrous oxide synthetase (iNOS) production during acute corneal injury as quantified by a Western blot analysis. Continuous topical administration of OFSCs for seven days improved corneal transparency, and this was accompanied by diffuse stromal engraftment of transplanted cells and differentiation into p63-expressing cells at the limbal area. The therapeutic effect of the

Topical administration of orbital fat-derived stem cells promotes corneal tissue regeneration

Science.gov (United States)

2013-01-01

Introduction Topical administration of eye drops is the major route for drug delivery to the cornea. Orbital fat-derived stem cells (OFSCs) possess an in vitro corneal epithelial differentiation capacity. Both the safety and immunomodulatory ability of systemic OFSC transplantation were demonstrated in our previous work. In this study, we investigated the safety, therapeutic effect, and mechanism(s) of topical OFSC administration in an extensive alkali-induced corneal wound. Methods Corneal injury was created by contact of a piece of 0.5 N NaOH-containing filter paper on the corneal surface of a male Balb/c mouse for 30 s. The area of the filter paper covered the central 70% or 100% of the corneal surface. OFSCs (2 × 105) in 5 μl phosphate-buffered saline (PBS) were given by topical administration (T) twice a day or by two intralimbal (IL) injections in the right cornea, while 5 μl of PBS in the left cornea served as the control. Results Topical OFSCs promoted corneal re-epithelialization of both the limbal-sparing and limbal-involved corneal wounds. In the first three days, topical OFSCs significantly reduced alkali-induced corneal edema and stromal infiltration according to a histopathological examination. Immunohistochemistry and immunofluorescence staining revealed that transplanted cells were easily detectable in the corneal epithelium, limbal epithelium and stroma, but only some of transplanted cells at the limbal epithelium had differentiated into cytokeratin 3-expressing cells. OFSCs did not alter neutrophil (Ly6G) levels in the cornea, but significantly reduced macrophage (CD68) infiltration and inducible nitrous oxide synthetase (iNOS) production during acute corneal injury as quantified by a Western blot analysis. Continuous topical administration of OFSCs for seven days improved corneal transparency, and this was accompanied by diffuse stromal engraftment of transplanted cells and differentiation into p63-expressing cells at the limbal area. The

Accounting interpretation of concession rights in the Republic of Bulgaria – topical issues  

Directory of Open Access Journals (Sweden)

Rumiana Pozharevska

2015-11-01

Full Text Available The subject of this paper covers the topical problems for the Republic of Bulgaria on the recognition, presentation and disclosure of concession rights and transactions for accounting purposes. The issues identified by the authors have a regulatory, theoretical character and concern their practical application. The aspects studied within this paper are: recognition of concession rights as intangible assets and their positioning in the total amount of assets of concessionaire enterprises; requirement and readiness for disclosure of information relating to concession agreements. The authors seek to suggest solutions in the specified directions.

Topic Modeling of Hierarchical Corpora /

OpenAIRE

Kim, Do-kyum

2014-01-01

The sizes of modern digital libraries have grown beyond our capacity to comprehend manually. Thus we need new tools to help us in organizing and browsing large corpora of text that do not require manually examining each document. To this end, machine learning researchers have developed topic models, statistical learning algorithms for automatic comprehension of large collections of text. Topic models provide both global and local views of a corpus; they discover topics that run through the co...

Visual communication on the covers of the journals Vijenac, Kolo and Zarez (1999 – 2011

Directory of Open Access Journals (Sweden)

Josipa Selthofer

2015-04-01

Full Text Available The aim of the paper is to analyse and compare graphic elements of visual communication on selected journal covers. The research was conducted using the covers of the journals Zarez, Vijenac and Kolo published from 1999 to 2011. The journal sample was selected based on the availability of periodicals, their topic and their cultural and social relevance. The research showed that visual communication on journal covers varies depending on the identity of the journal. Images are the key element in creating the message on the cover, they determine the way a journal communicates, giving it style, tone, and depth. Although thematically very similar, the journals we compared speak a different visual language. The main characteristic of Zarez is the daring and ironic visual communication that criticizes social events. In Vijenac, and in Kolo in particular, a more passive method of communication is used, which merely reflects the society and culture in which it is situated and about which it testifies. Focused on comments about general social and cultural events, without any real involvement, Kolo lacks the key element of visual communication that intrigues and directs readers' attention to the journal.

Testosterone Topical

Science.gov (United States)

... not apply any testosterone topical products to your penis or scrotum or to skin that has sores, ... are severe or do not go away: breast enlargement and/or pain decreased sexual desire acne depression ...

Recent topical research on global, energy, health & medical, and tourism economics, and global software: An overview

OpenAIRE

Chang, Chia-Lin; McAleer, Michael

2017-01-01

textabstractThe paper presents an overview of recent topical research on global, energy, health & medical, and tourism economics, and global software. We have interpreted "global" in the title of the Journal of Reviews on Global Economics to cover contributions that have a global impact on economics, thereby making it "global economics". In this sense, the paper is concerned with papers on global, energy, health & medical, and tourism economics, as well as global software algorithms that have...

Credibility improves topical blog post retrieval

NARCIS (Netherlands)

Weerkamp, W.; de Rijke, M.

2008-01-01

Topical blog post retrieval is the task of ranking blog posts with respect to their relevance for a given topic. To improve topical blog post retrieval we incorporate textual credibility indicators in the retrieval process. We consider two groups of indicators: post level (determined using

Topic prominence in Chinese EFL learners’ interlanguage

Directory of Open Access Journals (Sweden)

Shaopeng Li

2014-01-01

Full Text Available The present study aims to investigate the general characteristics of topicprominent typological interlanguage development of Chinese learners of English in terms of acquiring subject-prominent English structures from a discourse perspective. Topic structures mainly appear in Chinese discourse in the form of topic chains (Wang, 2002; 2004. The research target are the topic chain, which is the main topic-prominent structure in Chinese discourse, and zero anaphora, which is the most common topic anaphora in the topic chain. Two important findings emerged from the present study. First, the characteristics of Chinese topic chains are transferrable to the interlanguage of Chinese EFL learners, thus resulting in overgeneralization of the zero anaphora. Second, the interlanguage discourse of Chinese EFL learners reflects a change of the second language acquisition process from topic-prominence to subject-prominence, thus lending support to the discourse transfer hypothesis.

Land Cover

Data.gov (United States)

Kansas Data Access and Support Center — The Land Cover database depicts 10 general land cover classes for the State of Kansas. The database was compiled from a digital classification of Landsat Thematic...

Partially annotated bibliography for computer protection and related topics

Energy Technology Data Exchange (ETDEWEB)

Huskamp, J.C.

1976-07-20

References for the commonly cited technical papers in the area of computer protection are given. Great care is taken to exclude papers with no technical content or merit. For the purposes of this bibliography, computer protection is broadly defined to encompass all facets of the protection problem. The papers cover, but are not limited to, the topics of protection features in operating systems (e.g., MULTICS and HYDRA), hardware implementations of protection facilities (e.g., Honeywell 6180, System 250, BCC 5000, B6500), data base protection controls, confinement and protection models. Since computer protection is related to many other areas in computer science and electrical engineering, a bibliography of related areas is included after the protection bibliography. These sections also include articles of general interest in the named areas which are not necessarily related to protection.

Topical report review status: Volume 10

International Nuclear Information System (INIS)

1996-03-01

This report provides industry with procedures for submitting topical reports, guidance on how the U.S. Nuclear Regulatory Commission (NRC) processes and responds to topical report submittals, and an accounting, with review schedules, of all topical reports currently accepted for review by the NRC. This report is published annually

Chiropractic: MedlinePlus Health Topic

Science.gov (United States)

... for back pain (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Chiropractic updates by ... ENCYCLOPEDIA Chiropractic care for back pain Related Health Topics Back Pain Complementary and Integrative Medicine National Institutes ...

Diets: MedlinePlus Health Topic

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... Spanish Mediterranean diet (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Diets updates by ... foods Diet-busting foods Mediterranean diet Related Health Topics Child Nutrition DASH Eating Plan Diabetic Diet Nutrition ...

Colonoscopy: MedlinePlus Health Topic

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... Spanish Virtual colonoscopy (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Colonoscopy updates by ... Colonoscopy Colonoscopy discharge Sigmoidoscopy Virtual colonoscopy Related Health Topics Colonic Diseases Colonic Polyps Colorectal Cancer National Institutes ...

Dialysis: MedlinePlus Health Topic

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... access for hemodialysis (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Dialysis updates by ... for hemodialysis Show More Show Less Related Health Topics Creatinine Kidney Cysts Kidney Failure Peritoneal Disorders National ...

Menopause: MedlinePlus Health Topic

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... Spanish What is Menopause? (National Institute on Aging) Topic Image MedlinePlus Email Updates Get Menopause updates by ... test Menopause Types of hormone therapy Related Health Topics Hormone Replacement Therapy Menstruation Premature Ovarian Failure National ...

Vaginitis: MedlinePlus Health Topic

Science.gov (United States)

... Spanish Vulvovaginitis - overview (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Vaginitis updates by ... Vaginitis test - wet mount Vulvovaginitis - overview Related Health Topics Trichomoniasis Vaginal Diseases Yeast Infections Other Languages Find ...

Potential of Topical Curcumin in Reduction of TNF-α expression and Synovium Hyperplasia on Wistar Rats of Rheumatoid Arthritis Model

Directory of Open Access Journals (Sweden)

Ferri Widodo

2016-10-01

Full Text Available Rheumatoid arthritis is a chronic inflammatory autoimmune disease associated with articular and systemic effects. This disease affects synovial joints covered by a special tissue called synovium. Curcumin has a potent antioxidant, antiinflammatory agent, antiangiogenic and anticarcinogenic. Curcumin can downregulate the expression of various proinflammatory cytokines and is reported beneficial effects in arthritis, but has a poor solubility dan bioavailability as well. The purpose of this research was to study the potential of liposomes topikal curcumin in reducing athritis score, reducing the expression of TNF-α and histopathological synovium hyperplasia of hind paw on Wistar rats with CFA that had been treated with topical curcumin. In this study, rats were divided into 7 groups: positive control, negative control, rheumatoid arthritis with topical curcumin therapy of 90 mg/kg BW, rheumatoid arthritis with topical curcumin therapy of 110 mg/kg BW, rheumatoid arthritis with topical curcumin therapy of 200 mg/kg BW, rheumatoid arthritis with methotrexate therapy, rheumatoid arthritis with placebo therapy. Results from this experiment indicated that topical curcumin has no significant to the arthritis score, significantly effect to percentase expression of TNF-α (p<0.05 and could decrease synovium hyperplasia based on histophatology examination. It could be concluded that therapy of topical curcumin could decrease the expression of TNF- α and synovium hyperplasia in rheumatoid arthritis rat.

Topical Acne Treatments and Pregnancy

Science.gov (United States)

Topical Acne Treatments In every pregnancy, a woman starts out with a 3-5% chance of having a baby ... This sheet talks about whether exposure to topical acne treatments may increase the risk for birth defects ...

Symbiosis: Rich, Exciting, Neglected Topic

Science.gov (United States)

Rowland, Jane Thomas

1974-01-01

Argues that the topic of symbiosis has been greatly neglected and underemphasized in general-biology textbooks. Discusses many types and examples of symbiosis, and provides an extensive bibliography of the literature related to this topic. (JR)

Prediabetes:MedlinePlus Health Topic

Science.gov (United States)

... in Spanish Prediabetes (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Prediabetes updates by ... Glucose tolerance test - non-pregnant Prediabetes Related Health Topics A1C Diabetes Diabetes in Children and Teens Diabetes ...

Diabetes: MedlinePlus Health Topic

Science.gov (United States)

... High blood sugar (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Diabetes updates by ... ketones test Show More Show Less Related Health Topics A1C Blood Sugar Diabetes and Pregnancy Diabetes Complications ...

Evaluation of skin absorption of drugs from topical and transdermal formulations

Directory of Open Access Journals (Sweden)

André Luís Morais Ruela

Full Text Available ABSTRACT The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal formulations. In vitro and in vivo evaluations of these novel drug delivery systems are necessary to characterize their quality and efficacy. This review covers the most well-known methods for assessing the cutaneous absorption of drugs as an auxiliary tool for pharmaceutical formulation scientists in the design of drug delivery systems. In vitro methods as skin permeation assays using Franz-type diffusion cells, cutaneous retention and tape-stripping methods to study the cutaneous penetration of drugs, and in vivo evaluations as pre-clinical pharmacokinetic studies in animal models are discussed. Alternative approaches to cutaneous microdialysis are also covered. Recent advances in research on skin absorption of drugs and the effect of skin absorption enhancers, as investigated using confocal laser scanning microscopy, Raman confocal microscopy, and attenuated total reflectance Fourier-transform infrared spectroscopy, are reviewed.

Land use and land cover change based on historical space-time model

Science.gov (United States)

Sun, Qiong; Zhang, Chi; Liu, Min; Zhang, Yongjing

2016-09-01

Land use and cover change is a leading edge topic in the current research field of global environmental changes and case study of typical areas is an important approach understanding global environmental changes. Taking the Qiantang River (Zhejiang, China) as an example, this study explores automatic classification of land use using remote sensing technology and analyzes historical space-time change by remote sensing monitoring. This study combines spectral angle mapping (SAM) with multi-source information and creates a convenient and efficient high-precision land use computer automatic classification method which meets the application requirements and is suitable for complex landform of the studied area. This work analyzes the histological space-time characteristics of land use and cover change in the Qiantang River basin in 2001, 2007 and 2014, in order to (i) verify the feasibility of studying land use change with remote sensing technology, (ii) accurately understand the change of land use and cover as well as historical space-time evolution trend, (iii) provide a realistic basis for the sustainable development of the Qiantang River basin and (iv) provide a strong information support and new research method for optimizing the Qiantang River land use structure and achieving optimal allocation of land resources and scientific management.

Selected topics in phenomenology of the standard model

International Nuclear Information System (INIS)

Roberts, R.G.

1991-01-01

These lectures cover some aspects of phenomenology of topics in high energy physics which advertise the success of the standard model in dealing with a wide variety of experimental data. First we begin with a look at deep inelastic scattering. This tells us about the structure of the nucleon, which is understood in terms of the SU(3) gauge theory of QCD, which then allows the information on quark and gluon distributions to be carried over to other 'hard' processes such as hadronic production of jets. Recent data on electroweak processes can estimate the value of Sin 2 θw to a precision where the inclusion of radiative corrections allow bounds to be made on the mass of the top quark. Electroweak effects arise in e + e - collisions, but we first present a review of the recent history of this topic within the context of QCD. We bring the subject up to date with a look at the physics at (or near) the Z pole where the measurement of asymmetries can give more information. We look at the conventional description of quark mixing by the CKM matrix and see how the mixing parameters are systematically being extracted from a variety of reactions and decays. In turn, the values can be used to set bounds on the top quark mass. The matter of CP violation in weak interactions is addressed within the context of the standard model, recent data on ε'/ε being the source of current excitement. Finally, we at the theoretical description and experimental efforts to search for the top quark. (author)

Interrelationships between soil cover and plant cover depending on land use

Directory of Open Access Journals (Sweden)

Tiina Köster

2013-05-01

Full Text Available Interrelationships between soil cover and plant cover of normally developed (or postlithogenic mineral soils are analysed on the basis of four sampling soil groups. The four-link pedo-ecological sequence of analysed soils, rendzinas → brown soils → pseudopodzolic soils → gley-podzols, forms a representative cross section in relation to the normal mineral soils of Estonia. All groups differ substantially from each other in terms of soil properties (calcareousness, acidity, nutrition conditions, profile fabric and humus cover. The primary tasks of the research were (1 to elucidate the main pedo-ecological characteristics of the four soil groups and their suitability for plant cover, (2 to evaluate comparatively soils in terms of productivity, sustainability, biodiversity and environmental protection ability and (3 to analyse possibilities for ecologically sound matching of soil cover with suitable plant cover. On the basis of the same material, the influence of land-use change on humus cover (epipedon fabric, properties of the entire soil cover and soil–plant interrelationship were also analysed. An ecosystem approach enables us to observe particularities caused by specific properties of a soil type (species, variety in biological turnover and in the formation of biodiversity.

Tracking topic birth and death in LDA.

Energy Technology Data Exchange (ETDEWEB)

Wilson, Andrew T.; Robinson, David Gerald

2011-09-01

Most topic modeling algorithms that address the evolution of documents over time use the same number of topics at all times. This obscures the common occurrence in the data where new subjects arise and old ones diminish or disappear entirely. We propose an algorithm to model the birth and death of topics within an LDA-like framework. The user selects an initial number of topics, after which new topics are created and retired without further supervision. Our approach also accommodates many of the acceleration and parallelization schemes developed in recent years for standard LDA. In recent years, topic modeling algorithms such as latent semantic analysis (LSA)[17], latent Dirichlet allocation (LDA)[10] and their descendants have offered a powerful way to explore and interrogate corpora far too large for any human to grasp without assistance. Using such algorithms we are able to search for similar documents, model and track the volume of topics over time, search for correlated topics or model them with a hierarchy. Most of these algorithms are intended for use with static corpora where the number of documents and the size of the vocabulary are known in advance. Moreover, almost all current topic modeling algorithms fix the number of topics as one of the input parameters and keep it fixed across the entire corpus. While this is appropriate for static corpora, it becomes a serious handicap when analyzing time-varying data sets where topics come and go as a matter of course. This is doubly true for online algorithms that may not have the option of revising earlier results in light of new data. To be sure, these algorithms will account for changing data one way or another, but without the ability to adapt to structural changes such as entirely new topics they may do so in counterintuitive ways.

Statistical physics of hard combinatorial optimization: Vertex cover problem

Science.gov (United States)

Zhao, Jin-Hua; Zhou, Hai-Jun

2014-07-01

Typical-case computation complexity is a research topic at the boundary of computer science, applied mathematics, and statistical physics. In the last twenty years, the replica-symmetry-breaking mean field theory of spin glasses and the associated message-passing algorithms have greatly deepened our understanding of typical-case computation complexity. In this paper, we use the vertex cover problem, a basic nondeterministic-polynomial (NP)-complete combinatorial optimization problem of wide application, as an example to introduce the statistical physical methods and algorithms. We do not go into the technical details but emphasize mainly the intuitive physical meanings of the message-passing equations. A nonfamiliar reader shall be able to understand to a large extent the physics behind the mean field approaches and to adjust the mean field methods in solving other optimization problems.

Report of the Federal Ministry for the Environment, Nature Conservation, Buildings and Nuclear Safety (BMUB) on the topical peer review aging management in nuclear power plants and research reactors; Bericht des Bundesministeriums fuer Umwelt, Naturschutz, Bau und Reaktorsicherheit (BMUB) zum Topical Peer Review Alterungsmanagement in Kernkraftwerken und Forschungsreaktoren

Energy Technology Data Exchange (ETDEWEB)

NONE

2017-12-28

The report of the Federal Environmental Ministry (BMUB) on the topical peer review aging management in nuclear power plants and research reactors covers the following issues: comprehensive requirements for aging management and its implementation, electric cables, non accessible pipes, reactor pressure vessel, calandria/pressure tubes (CANDU), concrete containment, pre-stressed concrete reactor pressure vessel (AGR).

Handout on shielding calculation

International Nuclear Information System (INIS)

Heilbron Filho, P.F.L.

1991-01-01

In order to avoid the difficulties of the radioprotection supervisors in the tasks related to shielding calculations, is presented in this paper the basic concepts of shielding theory. It also includes exercises and examples. (author)

Handout on Health: Osteoporosis

Science.gov (United States)

... against gravity. Weight-bearing exercises include jogging, aerobics, hiking, walking, stair climbing, gardening, weight training, tennis, and dancing. High-impact exercises may provide the most benefit. Bicycling and swimming are not weight-bearing exercises, ...

Silicone covered vs. Non- covered endotracheal self expandable metallic stent: An experimental study

Energy Technology Data Exchange (ETDEWEB)

Do, Young Soo; Lee, Byung Hee; Kim, Soo Ah; Kim, Kie Hwan; Chin, Soo Yil; Cho, Kyung Ja; Cho, Dae Soon [Korea Cancer Center Hospital, Seoul (Korea, Republic of)

1994-10-15

To evaluate pathologic changes of the trachea and the lung after insertion of silicone covered and non covered Gianturco stent in the trachea of dog. Silicone covered(covered) and non covered(bare) Gianturco stent, six in each, were inserted into the tracheal lumen of six consecutive dogs. After 1-10 weeks observation, the dogs were sacrificed and their tracheas and lungs were examined grossly and histopathologically. Serial chest radiographs were performed to evaluate pneumonia and stent migration every 3-5 days. Pneumonia was observed in one of bare stent group and five of covered stent group. Stent migration was noted in three of covered stent group. In bare stent group, the epithelium of the trachea was markedly thickened by hyperplasia and stent was covered by granulation tissue from 6 weeks after stent insertion. Inflammation was focal at contact site between the stent and the trachea. In covered stent group, the epithelium was denuded at multiple areas and there were multifocal squamous metaplasia of the mucosa. Inflammatory reaction of the trachea was diffuse. Inflammatory reaction was more severe and stent migration was more frequent in covered stent group. The use of covered stent in the trachea should be studied further.

Preliminary stop of the TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC) trial

NARCIS (Netherlands)

Koeneman, M. M.; Kruse, Arnold-Jan; Kooreman, L. F. S.; zur Hausen, Axel; Hopman, Anton H N; Sep, S. J. S.; Van Gorp, T.; Slangen, B. F. M.; van Beekhuizen, H. J.; de Sande, Michiel A. J. van; Gerestein, Cornelis G.; Nijman, H. W.; Kruitwagen, R. F. M. P.

2017-01-01

The "TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia" (TOPIC) trial was stopped preliminary, due to lagging inclusions. This study aimed to evaluate the treatment efficacy and clinical applicability of imiquimod 5% cream in high-grade cervical intraepithelial neoplasia

Deep Unfolding for Topic Models.

Science.gov (United States)

Chien, Jen-Tzung; Lee, Chao-Hsi

2018-02-01

Deep unfolding provides an approach to integrate the probabilistic generative models and the deterministic neural networks. Such an approach is benefited by deep representation, easy interpretation, flexible learning and stochastic modeling. This study develops the unsupervised and supervised learning of deep unfolded topic models for document representation and classification. Conventionally, the unsupervised and supervised topic models are inferred via the variational inference algorithm where the model parameters are estimated by maximizing the lower bound of logarithm of marginal likelihood using input documents without and with class labels, respectively. The representation capability or classification accuracy is constrained by the variational lower bound and the tied model parameters across inference procedure. This paper aims to relax these constraints by directly maximizing the end performance criterion and continuously untying the parameters in learning process via deep unfolding inference (DUI). The inference procedure is treated as the layer-wise learning in a deep neural network. The end performance is iteratively improved by using the estimated topic parameters according to the exponentiated updates. Deep learning of topic models is therefore implemented through a back-propagation procedure. Experimental results show the merits of DUI with increasing number of layers compared with variational inference in unsupervised as well as supervised topic models.

Topics in statistical data analysis for high-energy physics

International Nuclear Information System (INIS)

Cowan, G.

2011-01-01

These lectures concert two topics that are becoming increasingly important in the analysis of high-energy physics data: Bayesian statistics and multivariate methods. In the Bayesian approach, we extend the interpretation of probability not only to cover the frequency of repeatable outcomes but also to include a degree of belief. In this way we are able to associate probability with a hypothesis and thus to answer directly questions that cannot be addressed easily with traditional frequentist methods. In multivariate analysis, we try to exploit as much information as possible from the characteristics that we measure for each event to distinguish between event types. In particular we will look at a method that has gained popularity in high-energy physics in recent years: the boosted decision tree. Finally, we give a brief sketch of how multivariate methods may be applied in a search for a new signal process. (author)

The identification of van Hiele level students on the topic of space analytic geometry

Science.gov (United States)

Yudianto, E.; Sunardi; Sugiarti, T.; Susanto; Suharto; Trapsilasiwi, D.

2018-03-01

Geometry topics are still considered difficult by most students. Therefore, this study focused on the identification of students related to van Hiele levels. The task used from result of the development of questions related to analytical geometry of space. The results of the work involving 78 students who worked on these questions covered 11.54% (nine students) classified on a visual level; 5.13% (four students) on analysis level; 1.28% (one student) on informal deduction level; 2.56% (two students) on deduction and 2.56% (two students) on rigor level, and 76.93% (sixty students) classified on the pre-visualization level.

Bimatoprost Topical

Science.gov (United States)

... not use a cotton swab or any other brush or applicator to apply topical bimatoprost.To use the solution, follow these steps: Wash your hands and face thoroughly with soap and water. Be sure that all makeup is removed. Do not let the tip of ...

International topical meeting on nuclear research applications and utilization of accelerators. Book of abstracts

International Nuclear Information System (INIS)

2009-01-01

Applications of particle accelerators cover a number of areas, from strategic and applied research, safety and security, environmental applications, materials research and analytical sciences, to radioisotope production and radiation processing. Accelerator based techniques and pulsed neutron sources are expected to lead to new initiatives in materials research of relevance for both the nuclear and non-nuclear fields. Material science studies with the use of accelerators, neutron beams and other nuclear analytical methods are relevant to the development of advanced reactors, nuclear fuel cycle needs and fusion research. In this regard, a better understanding of the irradiation effects in materials for energy and non-energy applications is needed, and is reflected in accelerator techniques for modification and analysis of materials for nuclear technologies. Accelerator applications for innovative nuclear systems aiming at rad-waste transmutation (e.g., accelerator driven systems) are being pursued in many countries. Research and development using accelerators involves a broad spectrum of skills to build a cadre of trained experts in nuclear techniques in IAEA Member States, and to generate knowledge for innovative methodologies and tools. The present conference is also being held in cooperation with the American Nuclear Society (ANS), which successfully organized the series of accelerator applications conferences known as AccApp. The ANS series of topical meetings has provided a forum for the global exchange of scientific and technical knowledge on a wide variety of related topics since the first AccApp took place in 1997 in Albuquerque, USA. The last conference which was held in 2007 in Pocatello, USA, was jointly organized by the ANS and the IAEA. The main objectives of the conference are to promote exchange of information among IAEA Member States representatives/delegates and to discuss new trends in accelerator applications including nuclear materials research

Using hot lab to increase pre-service physics teacher’s critical thinking skills related to the topic of RLC circuit

Science.gov (United States)

Malik, A.; Setiawan, A.; Suhandi, A.; Permanasari, A.; Samsudin, A.; Safitri, D.; Lisdiani, S. A. S.; Sapriadil, S.; Hermita, N.

2018-05-01

This research purposes to explore the used of Higher Order Thinking Laboratory (HOT-Lab) in enhancing the critical thinking skills of pre-service teachers related to the topic of Resistors, Inductors, Capacitor (RLC circuit). This study utilised a quasi-experiment method with Pretest-Posttest Control Group design. The sample of the study was 60 students that were divided into two groups covering in experiment and control group, consists of 30 students. The instrument for measuring critical thinking skills is essay test. Data has been analyzed using normalized gain average, effect size, and t-test. The results show that students’ critical thinking skills using the HOT Lab are higher than the verification lab. Using HOT-lab was implemented in the form of activity in the laboratory can improve high-order thinking skills. Hence, it was concluded that the use of HOT Lab had a greater impact on improving students’ critical thinking skills on RLC topic. Finally, HOT Lab can be used for other physics topics.

A review of scientific topics and literature in abdominal radiology in Germany. Pt. 2. Abdominal parenchymal organs

Energy Technology Data Exchange (ETDEWEB)

Grenacher, L. [Diagnostik Muenchen-Diagnostic Imaging Centre (Germany); Juchems, M.S. [Konstanz Hospital (Germany). Diagnostic and Interventional Radiology; Holzapfel, K. [Technische Univ. Muenchen (Germany). Dept. of Radiology; Kinner, S.; Lauenstein, T.C. [University Hospital Essen (Germany). Dept. of Radiology; Wessling, J. [Clemens Hospital Muenchen (Germany). Dept. of Radiology; Schreyer, A.G. [University Hospital Regenburg (Germany). Dept. of Radiology

2016-03-15

The working group for abdominal and gastrointestinal diagnosis is a group of the German Radiological Society (DRG) focusing clinically and scientifically on the diagnosis and treatment of the gastrointestinal tract as well as the parenchymal abdominal organs. In this article we give an up-to-date literature review of scientific radiological topics especially covered by German radiologists. The working group experts cover the most recent relevant studies concerning liver-specific contrast media with an emphasis on a new classification system for liver adenomas. Additionally studies regarding selective internal radiotherapy (SIRT) are reviewed. For the pancreas the most important tumors are described followed by an introduction to the most recently introduced functional imaging techniques. The manuscript concludes with some remarks on recent studies and concerning chronic pancreatitis as well as autoimmune pancreatitis.

Topics in quantum field theory

NARCIS (Netherlands)

Dams, C.J.F.

2006-01-01

In this PhD-thesis some topics in quantum field theory are considered. The first chapter gives a background to these topics. The second chapter discusses renormalization. In particular it is shown how loop calculations can be performed when using the axial gauge fixing. Fermion creation and

XXXII International Meeting on Fundamental physics. Selected Topics in Particle and Astroparticle Physics. Alicante, Spain, March 1-5, 2004

International Nuclear Information System (INIS)

Hernandez Rey, J. J.; Zuniga Roman, J.

2005-01-01

The XXXII International Winter Meeting on Fundamental Physics took place in Alicante, Spain, from March 1st to 5th, 2004. The lectures covered a wide range of topics on Experimental and theoretical Particle and Astroparticle Physics, such as Neutrino Oscillations and Mixing, LHC Physics, Grid Computing, Flavour Physics, CP violation, Cosmology, Cosmic ray, Gamma and Neutrino Astrophysics and on the Technology, Detectors and Physics of the Linear Collider. (Author)

Branched polynomial covering maps

DEFF Research Database (Denmark)

Hansen, Vagn Lundsgaard

2002-01-01

A Weierstrass polynomial with multiple roots in certain points leads to a branched covering map. With this as the guiding example, we formally define and study the notion of a branched polynomial covering map. We shall prove that many finite covering maps are polynomial outside a discrete branch ...... set. Particular studies are made of branched polynomial covering maps arising from Riemann surfaces and from knots in the 3-sphere. (C) 2001 Elsevier Science B.V. All rights reserved.......A Weierstrass polynomial with multiple roots in certain points leads to a branched covering map. With this as the guiding example, we formally define and study the notion of a branched polynomial covering map. We shall prove that many finite covering maps are polynomial outside a discrete branch...

Learning topic models by belief propagation.

Science.gov (United States)

Zeng, Jia; Cheung, William K; Liu, Jiming

2013-05-01

Latent Dirichlet allocation (LDA) is an important hierarchical Bayesian model for probabilistic topic modeling, which attracts worldwide interest and touches on many important applications in text mining, computer vision and computational biology. This paper represents the collapsed LDA as a factor graph, which enables the classic loopy belief propagation (BP) algorithm for approximate inference and parameter estimation. Although two commonly used approximate inference methods, such as variational Bayes (VB) and collapsed Gibbs sampling (GS), have gained great success in learning LDA, the proposed BP is competitive in both speed and accuracy, as validated by encouraging experimental results on four large-scale document datasets. Furthermore, the BP algorithm has the potential to become a generic scheme for learning variants of LDA-based topic models in the collapsed space. To this end, we show how to learn two typical variants of LDA-based topic models, such as author-topic models (ATM) and relational topic models (RTM), using BP based on the factor graph representations.

Mekong Land Cover Dasboard: Regional Land Cover Mointoring Systems

Science.gov (United States)

Saah, D. S.; Towashiraporn, P.; Aekakkararungroj, A.; Phongsapan, K.; Triepke, J.; Maus, P.; Tenneson, K.; Cutter, P. G.; Ganz, D.; Anderson, E.

2016-12-01

SERVIR-Mekong, a USAID-NASA partnership, helps decision makers in the Lower Mekong Region utilize GIS and Remote Sensing information to inform climate related activities. In 2015, SERVIR-Mekong conducted a geospatial needs assessment for the Lower Mekong countries which included individual country consultations. The team found that many countries were dependent on land cover and land use maps for land resource planning, quantifying ecosystem services, including resilience to climate change, biodiversity conservation, and other critical social issues. Many of the Lower Mekong countries have developed national scale land cover maps derived in part from remote sensing products and geospatial technologies. However, updates are infrequent and classification systems do not always meet the needs of key user groups. In addition, data products stop at political boundaries and are often not accessible making the data unusable across country boundaries and with resource management partners. Many of these countries rely on global land cover products to fill the gaps of their national efforts, compromising consistency between data and policies. These gaps in national efforts can be filled by a flexible regional land cover monitoring system that is co-developed by regional partners with the specific intention of meeting national transboundary needs, for example including consistent forest definitions in transboundary watersheds. Based on these facts, key regional stakeholders identified a need for a land cover monitoring system that will produce frequent, high quality land cover maps using a consistent regional classification scheme that is compatible with national country needs. SERVIR-Mekong is currently developing a solution that leverages recent developments in remote sensing science and technology, such as Google Earth Engine (GEE), and working together with production partners to develop a system that will use a common set of input data sources to generate high

Bare quantifier fronting as contrastive topicalization

Directory of Open Access Journals (Sweden)

Ion Giurgea

2015-11-01

Full Text Available I argue that indefinites (in particular bare quantifiers such as ‘something’, ‘somebody’, etc. which are neither existentially presupposed nor in the restriction of a quantifier over situations, can undergo topicalization in a number of Romance languages (Catalan, Italian, Romanian, Spanish, but only if the sentence contains “verum” focus, i.e. focus on a high degree of certainty of the sentence. I analyze these indefinites as contrastive topics, using Büring’s (1999 theory (where the term ‘S-topic’ is used for what I call ‘contrastive topic’. I propose that the topic is evaluated in relation to a scalar set including generalized quantifiers such as {lP $x P(x, lP MANYx P(x, lP MOSTx P(x, lP “xP(x} or {lP $xP(x, lP P(a, lP P(b …}, and that the contrastive topic is the weakest generalized quantifier in this set. The verum focus, which is part of the “comment” that co-occurs with the “Topic”, introduces a set of alternatives including degrees of certainty of the assertion. The speaker asserts that his claim is certainly true or highly probable, contrasting it with stronger claims for which the degree of probability is unknown. This explains the observation that in downward entailing contexts, the fronted quantified DPs are headed by ‘all’ or ‘many’, whereas ‘some’, small numbers or ‘at least n’ appear in upward entailing contexts. Unlike other cases of non-specific topics, which are property topics, these are quantifier topics: the topic part is a generalized quantifier, the comment is a property of generalized quantifiers. This explains the narrow scope of the fronted quantified DP.

Land cover mapping of North and Central America—Global Land Cover 2000

Science.gov (United States)

Latifovic, Rasim; Zhu, Zhi-Liang

2004-01-01

The Land Cover Map of North and Central America for the year 2000 (GLC 2000-NCA), prepared by NRCan/CCRS and USGS/EROS Data Centre (EDC) as a regional component of the Global Land Cover 2000 project, is the subject of this paper. A new mapping approach for transforming satellite observations acquired by the SPOT4/VGTETATION (VGT) sensor into land cover information is outlined. The procedure includes: (1) conversion of daily data into 10-day composite; (2) post-seasonal correction and refinement of apparent surface reflectance in 10-day composite images; and (3) extraction of land cover information from the composite images. The pre-processing and mosaicking techniques developed and used in this study proved to be very effective in removing cloud contamination, BRDF effects, and noise in Short Wave Infra-Red (SWIR). The GLC 2000-NCA land cover map is provided as a regional product with 28 land cover classes based on modified Federal Geographic Data Committee/Vegetation Classification Standard (FGDC NVCS) classification system, and as part of a global product with 22 land cover classes based on Land Cover Classification System (LCCS) of the Food and Agriculture Organisation. The map was compared on both areal and per-pixel bases over North and Central America to the International Geosphere–Biosphere Programme (IGBP) global land cover classification, the University of Maryland global land cover classification (UMd) and the Moderate Resolution Imaging Spectroradiometer (MODIS) Global land cover classification produced by Boston University (BU). There was good agreement (79%) on the spatial distribution and areal extent of forest between GLC 2000-NCA and the other maps, however, GLC 2000-NCA provides additional information on the spatial distribution of forest types. The GLC 2000-NCA map was produced at the continental level incorporating specific needs of the region.

Resources for Topics in Architecture.

Science.gov (United States)

Van Noate, Judith, Comp.

This guide for conducting library research on topics in architecture or on the work of a particular architect presents suggestions for utilizing four categories of resources: books, dictionaries and encyclopedias, indexes, and a periodicals and series list (PASL). Two topics are researched as examples: the contemporary architect Richard Meier, and…

Web directories as topical context

NARCIS (Netherlands)

Kaptein, R.; Kamps, J.; Aly, R.; Hauff, C.; den Hamer, I.; Hiemstra, D.; Huibers, T.; de Jong, F.

2009-01-01

In this paper we explore whether the Open Directory (or DMOZ) can be used to classify queries into topical categories on different levels and whether we can use this topical context to improve retrieval performance. We have set up a user study to let test persons explicitly classify queries into

Land Cover Classification Using Integrated Spectral, Temporal, and Spatial Features Derived from Remotely Sensed Images

Directory of Open Access Journals (Sweden)

Yongguang Zhai

2018-03-01

Full Text Available Obtaining accurate and timely land cover information is an important topic in many remote sensing applications. Using satellite image time series data should achieve high-accuracy land cover classification. However, most satellite image time-series classification methods do not fully exploit the available data for mining the effective features to identify different land cover types. Therefore, a classification method that can take full advantage of the rich information provided by time-series data to improve the accuracy of land cover classification is needed. In this paper, a novel method for time-series land cover classification using spectral, temporal, and spatial information at an annual scale was introduced. Based on all the available data from time-series remote sensing images, a refined nonlinear dimensionality reduction method was used to extract the spectral and temporal features, and a modified graph segmentation method was used to extract the spatial features. The proposed classification method was applied in three study areas with land cover complexity, including Illinois, South Dakota, and Texas. All the Landsat time series data in 2014 were used, and different study areas have different amounts of invalid data. A series of comparative experiments were conducted on the annual time-series images using training data generated from Cropland Data Layer. The results demonstrated higher overall and per-class classification accuracies and kappa index values using the proposed spectral-temporal-spatial method compared to spectral-temporal classification methods. We also discuss the implications of this study and possibilities for future applications and developments of the method.

Topical sucralfate treatment of anal fistulotomy wounds: a randomized placebo-controlled trial.

Science.gov (United States)

Gupta, Pravin J; Heda, Purushottam S; Shrirao, Subhash A; Kalaskar, Surekha S

2011-06-01

Sucralfate is a cytoprotective agent which adheres to mucoproteins and forms a protective barrier at wound sites. In oral form it is a common ulcer medication, and as a topical preparation it has been used to treat a wide variety of wounds. The present study was designed to evaluate the effectiveness and safety of topical sucralfate in wound healing after anal fistulotomy. Double-blind, randomized controlled study comparing topical application of sucralfate or placebo. Private outpatient clinic specializing in anorectal disease in Nagpur, India. Patients with a wound length of at least 5 cm after low anal fistulotomy were eligible for the study. Patients were randomly assigned to receive ointment containing 7% sucralfate or a placebo ointment consisting of petroleum jelly. Patients were instructed to apply approximately 3 g of ointment to the wound twice daily after a sitz bath for 6 weeks or until the wound had healed. The wounds were examined by a blinded independent observer at 2, 4, and 6 weeks after the operation. The primary end point was the proportion of patients with wounds that had completely healed. Secondary end points included amount of mucosal covering (scored by the observer), adverse events, and postoperative pain (self-rated on a visual analog scale). Of 80 participants (29 women, 51 men; median age, 23 (range, 17-49) years), 76 participants completed the trial (sucralfate, 39; placebo, 37). At 6-week follow-up, complete wound healing was achieved in 37 patients (95%) in the sucralfate group and 27 patients (73%) in the placebo group (P = .009). Mucosal coverage of the wound was significantly greater with sucralfate than with placebo at each measurement point (P = .01). No adverse events were observed. Postoperative pain scores were significantly lower for sucralfate than for placebo at 2 and 4 weeks after the start of treatment. Wound tissue specimens were not available for morphological and ultrastructural analysis. The results of this study add

Link-topic model for biomedical abbreviation disambiguation.

Science.gov (United States)

Kim, Seonho; Yoon, Juntae

2015-02-01

The ambiguity of biomedical abbreviations is one of the challenges in biomedical text mining systems. In particular, the handling of term variants and abbreviations without nearby definitions is a critical issue. In this study, we adopt the concepts of topic of document and word link to disambiguate biomedical abbreviations. We newly suggest the link topic model inspired by the latent Dirichlet allocation model, in which each document is perceived as a random mixture of topics, where each topic is characterized by a distribution over words. Thus, the most probable expansions with respect to abbreviations of a given abstract are determined by word-topic, document-topic, and word-link distributions estimated from a document collection through the link topic model. The model allows two distinct modes of word generation to incorporate semantic dependencies among words, particularly long form words of abbreviations and their sentential co-occurring words; a word can be generated either dependently on the long form of the abbreviation or independently. The semantic dependency between two words is defined as a link and a new random parameter for the link is assigned to each word as well as a topic parameter. Because the link status indicates whether the word constitutes a link with a given specific long form, it has the effect of determining whether a word forms a unigram or a skipping/consecutive bigram with respect to the long form. Furthermore, we place a constraint on the model so that a word has the same topic as a specific long form if it is generated in reference to the long form. Consequently, documents are generated from the two hidden parameters, i.e. topic and link, and the most probable expansion of a specific abbreviation is estimated from the parameters. Our model relaxes the bag-of-words assumption of the standard topic model in which the word order is neglected, and it captures a richer structure of text than does the standard topic model by considering

Unsupervised topic discovery by anomaly detection

OpenAIRE

Cheng, Leon

2013-01-01

Approved for public release; distribution is unlimited With the vast amount of information and public comment available online, it is of increasing interest to understand what is being said and what topics are trending online. Government agencies, for example, want to know what policies concern the public without having to look through thousands of comments manually. Topic detection provides automatic identification of topics in documents based on the information content and enhances many ...

Topical cyclosporine for atopic keratoconjunctivitis.

Science.gov (United States)

González-López, Julio J; López-Alcalde, Jesús; Morcillo Laiz, Rafael; Fernández Buenaga, Roberto; Rebolleda Fernández, Gema

2012-09-12

Atopic keratoconjunctivitis (AKC) is a chronic ocular surface non-infectious inflammatory condition that atopic dermatitis patients may suffer at any time point in the course of their dermatologic disease and is independent of its degree of severity. AKC is usually not self resolving and it poses a higher risk of corneal injuries and severe sequelae. Management of AKC should prevent or treat corneal damage. Although topical corticosteroids remain the standard treatment for patients with AKC, prolonged use may lead to complications. Topical cyclosporine A (CsA) may improve AKC signs and symptoms, and be used as a corticosteroid sparing agent. To determine the efficacy and gather evidence on safety from randomised controlled trials (RCTs) of topical CsA in patients with AKC. We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2012, Issue 6), MEDLINE (January 1946 to July 2012), EMBASE (January 1980 to July 2012), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to July 2012), Cumulative Index to Nursing and Allied Health Literature (CINAHL) (January 1937 to July 2012), OpenGrey (System for Information on Grey Literature in Europe) (www.opengrey.eu/), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov), the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en), the IFPMA Clinical Trials Portal (http://clinicaltrials.ifpma.org/no_cache/en/myportal/index.htm) and Web of Science Conference Proceedings Citation Index- Science (CPCI-S). We did not use any date or language restrictions in the electronic searches for trials. The electronic databases were last searched on 9 July 2012. We also handsearched the following conference proceedings: American Academy of Ophthalmology, Association for Research in Vision and Ophthalmology, International Council of Opthalmology and Societas

21 CFR 868.5170 - Laryngotracheal topical anesthesia applicator.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Laryngotracheal topical anesthesia applicator. 868... topical anesthesia applicator. (a) Identification. A laryngotracheal topical anesthesia applicator is a device used to apply topical anesthetics to a patient's laryngotracheal area. (b) Classification. Class...

Topical therapy of atopic dermatitis: controversies from Hippocrates to topical immunomodulators.

Science.gov (United States)

Tilles, Gérard; Wallach, Daniel; Taïeb, Alain

2007-02-01

Although atopic dermatitis can be treated efficiently, there is still much controversy about the risk/benefit ratio of both topical corticosteroids and topical immunomodulators. Conflicting data may be found about the usefulness of bathing, diet regulation, and other therapeutic interventions. These controversies result in part from the persistence of Hippocratic doctrines in modern medical thinking. Humoralist and diathetic doctrines, as they pertain to eczema, are reviewed. The paradoxical worsening of oozing and the deadly hazards of hospitalization before the era of antibiotics are brought to mind. We hope that this historical review will improve the understanding of current controversies and help dermatologists to manage patients with atopic dermatitis and other chronic skin diseases.

Topic Time Series Analysis of Microblogs

Science.gov (United States)

2014-10-01

may be distributed more globally. Tweets on a specific topic that cluster spatially, temporally or both might be of interest to analysts, marketers ...of $ and @, with the latter only in the case that it is the only character in the token (the @ symbol is significant in its usage by Instagram in...is generated by Instagram . Topic 80, Distance: 143.2101 Top words: 1. rawr 2. ˆ0ˆ 3. kill 4. jurassic 5. dinosaur Analysis: This topic is quite

Topic modelling in the information warfare domain

CSIR Research Space (South Africa)

De Waal, A

2013-11-01

Full Text Available for interesting and relevant topics. The objectives of this paper is to describe topic modelling, put it in context as a useful IW technique and illustrate its use with two examples. They discuss several applications of topic modelling in the safety and security...

Task-Driven Comparison of Topic Models.

Science.gov (United States)

Alexander, Eric; Gleicher, Michael

2016-01-01

Topic modeling, a method of statistically extracting thematic content from a large collection of texts, is used for a wide variety of tasks within text analysis. Though there are a growing number of tools and techniques for exploring single models, comparisons between models are generally reduced to a small set of numerical metrics. These metrics may or may not reflect a model's performance on the analyst's intended task, and can therefore be insufficient to diagnose what causes differences between models. In this paper, we explore task-centric topic model comparison, considering how we can both provide detail for a more nuanced understanding of differences and address the wealth of tasks for which topic models are used. We derive comparison tasks from single-model uses of topic models, which predominantly fall into the categories of understanding topics, understanding similarity, and understanding change. Finally, we provide several visualization techniques that facilitate these tasks, including buddy plots, which combine color and position encodings to allow analysts to readily view changes in document similarity.

LAFD: TA-55 RLUOB/CUB Facility Familiarization Tour, OJT #55265

Energy Technology Data Exchange (ETDEWEB)

Rutherford, Victor Stephen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-09-14

Los Alamos National Laboratory (LANL) conducts familiarization tours for personnel of the Los Alamos County Fire Department (LAFD) at the RLUOB/CUB, technical area (TA)-55, 400/440, facility, Radiological Laboratory Utility Office Building (RLUOB)/Central Utility Building (CUB). These familiarization tours are official LANL business; the purpose of these tours is to orient LAFD firefighters to the facility so that they can respond efficiently and quickly to a variety of emergency situations. This orientation includes, among other topics, the ingress and egress of the area and buildings, layout and organization of the facility, evacuation procedures and assembly points, and areas of concern within the various buildings at the facility. LAFD firefighters have the skills and abilities to perform firefighting operations and other emergency response tasks that cannot be provided by other LANL personnel who have the required clearance level. This handout provides details of the information, along with maps and diagrams, to be presented during the familiarization tours. The handout is distributed to the trainees at the time of the tour; a corresponding checklist is also used as guidance during the familiarization tours to ensure that all required information is presented to LAFD personnel.

Leaves of knowledge, a collectable publication for dissemination of scientific and technological topics

International Nuclear Information System (INIS)

Spurio, S. M.

2013-01-01

The Institute of Energy and Sustainable Development (IEDS) of the National Atomic Energy Commission of Argentina performs an active task of popularization of nuclear science and technology applications and its spin-off activities. The IEDS, based on this goal and the known expression of Descartes 'Science branches intertwine in the Tree of Knowledge' has been making the annual task of inviting authors, editing, publishing and often, printing the publication Leaves of Knowledge, since 2008 and without interruption. The presentation format consists in a holder folder containing collectibles sheets. Each sheet represents a leaf on the Tree Science Knowledge. The publication encourages the participation of renowned professionals invited from CNEA and other Institutions who are committing to writing just two pages of their topic specialty. As to the fifth edition currently being edited, 56 items have already been published on the following seven general topics: ENVIRONMENT - APPLICATIONS - SCIENCE - ENERGY - MATERIALS - HEALTH - SAFETY. Although it was originally aimed to the general public, now it has evolved into three distinct approaches also covering universitary and professional level. Its PDF version is available to the public through the IEDS website and it was registered under its corresponding ISBN. (author)

Topical steroid addiction in atopic dermatitis

Directory of Open Access Journals (Sweden)

Fukaya M

2014-10-01

Full Text Available Mototsugu Fukaya,1 Kenji Sato,2 Mitsuko Sato,3 Hajime Kimata,4 Shigeki Fujisawa,5 Haruhiko Dozono,6 Jun Yoshizawa,7 Satoko Minaguchi8 1Tsurumai Kouen Clinic, Nagoya, 2Department of Dermatology, Hannan Chuo Hospital, Osaka, 3Sato Pediatric Clinic, Osaka, 4Kimata Hajime Clinic, Osaka, 5Fujisawa Dermatology Clinic, Tokyo, 6Dozono Medical House, Kagoshima, 7Yoshizawa Dermatology Clinic, Yokohama, 8Department of Dermatology, Kounosu Kyousei Hospital, Saitama, Japan Abstract: The American Academy of Dermatology published a new guideline regarding topical therapy in atopic dermatitis in May 2014. Although topical steroid addiction or red burning skin syndrome had been mentioned as possible side effects of topical steroids in a 2006 review article in the Journal of the American Academy of Dermatology, no statement was made regarding this illness in the new guidelines. This suggests that there are still controversies regarding this illness. Here, we describe the clinical features of topical steroid addiction or red burning skin syndrome, based on the treatment of many cases of the illness. Because there have been few articles in the medical literature regarding this illness, the description in this article will be of some benefit to better understand the illness and to spur discussion regarding topical steroid addiction or red burning skin syndrome. Keywords: topical steroid addiction, atopic dermatitis, red burning skin syndrome, rebound, corticosteroid, eczema

NATO Advanced Research Workshop on Approximation by Solutions of Partial Differential Equations, Quadrature Formulae, and Related Topics

CERN Document Server

Goldstein, M; Haussmann, W; Hayman, W; Rogge, L

1992-01-01

This volume consists of the proceedings of the NATO Advanced Research Workshop on Approximation by Solutions of Partial Differential Equations, Quadrature Formulae, and Related Topics, which was held at Hanstholm, Denmark. These proceedings include the main invited talks and contributed papers given during the workshop. The aim of these lectures was to present a selection of results of the latest research in the field. In addition to covering topics in approximation by solutions of partial differential equations and quadrature formulae, this volume is also concerned with related areas, such as Gaussian quadratures, the Pompelu problem, rational approximation to the Fresnel integral, boundary correspondence of univalent harmonic mappings, the application of the Hilbert transform in two dimensional aerodynamics, finely open sets in the limit set of a finitely generated Kleinian group, scattering theory, harmonic and maximal measures for rational functions and the solution of the classical Dirichlet problem. In ...

47{sup th} Annual conference on nuclear technology (AMNT 2016). Key topics / Outstanding know-how and sustainable innovations - enhanced safety and operation excellence

Energy Technology Data Exchange (ETDEWEB)

Raetzke, Christian [CONLAR - Consulting on Nuclear Law, Licensing and Regulation, Leipzig (Germany); Fischer, Erwin [PreussenElektra GmbH, Hannover (Germany). Management Board; Mohrbach, Ludger [VGB PowerTech e.V., Essen (Germany). Competence Center ' ' Nuclear Power Plants' '

2016-08-15

Summary report on the Key Topics ''Outstanding Know-How and Sustainable Innovations'' and ''Enhanced Safety and Operation Excellence'' of the 47{sup th} Annual Conference on Nuclear Technology (AMNT 2016) held in Hamburg, 10 to 12 May 2016. Other Sessions of AMNT 2016 will be covered in further issues of atw.

Eye Wear: MedlinePlus Health Topic

Science.gov (United States)

... When You Exercise (National Institute on Aging) - PDF Topic Image MedlinePlus Email Updates Get Eye Wear updates by email What's this? GO Related Health Topics Refractive Errors National Institutes of Health The primary ...

21 CFR 524.1193 - Ivermectin topical solution.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Ivermectin topical solution. 524.1193 Section 524...) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.1193 Ivermectin topical solution. (a) Specifications. Each milliliter (mL) of solution contains 5 milligrams of...

Gigafida and slWaC: topic comparison

Directory of Open Access Journals (Sweden)

Nataša Logar Berginc

2013-05-01

Full Text Available In the article, the following two issues are analyzed: (a incorporation of texts from the Internet into existing reference corpora and comparison with the existence of web corpora, and (b the latest two corpora of Slovenian language texts: the Gigafida corpus consisting mainly of printed texts and to a lesser extent also web texts, and the slWaC corpus which is entirely compiled from web texts. First, similarities and differences between the two corpora are identified using the topic modelling method, and then the same method is applied to the individual taxonomic categories of the Gigafida corpus. The first part of the analysis showed that the work of reference corpus compilers is currently still incoherent with regard to the incorporation of Internet texts into corpora which should reveal the overall picture of a certain language. In case compilers decide to incorporate web texts, the range of included genres is generally broad. The second part of the analysis showed a significant thematic variation between the Gigafida and slWaC corpora, and pointed out the most typical themes covered by each of the six Gigafida corpus parts.

Eosinophilic Esophagitis: MedlinePlus Health Topic

Science.gov (United States)

... Esophagitis (EoE) (American Academy of Allergy, Asthma, and Immunology) Also in Spanish Latest News Eosinophilic Esophagitis May ... Pediatric and Adolescent Patients (American College of Gastroenterology) Topic Image Related Health Topics Eosinophilic Disorders Esophagus Disorders ...

Female Infertility: MedlinePlus Health Topic

Science.gov (United States)

... Prolactin blood test (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Female Infertility updates ... Serum progesterone Show More Show Less Related Health Topics Assisted Reproductive Technology Infertility Male Infertility National Institutes ...

Mobility Aids: MedlinePlus Health Topic

Science.gov (United States)

... Mobility Problems (AGS Foundation for Health in Aging) Topic Image MedlinePlus Email Updates Get Mobility Aids updates ... standing and walking Using a cane Related Health Topics Assistive Devices Other Languages Find health information in ...

Genetic Testing: MedlinePlus Health Topic

Science.gov (United States)

... Your Family's Health (National Institutes of Health) - PDF Topic Image MedlinePlus Email Updates Get Genetic Testing updates ... testing and your cancer risk Karyotyping Related Health Topics Birth Defects Genetic Counseling Genetic Disorders Newborn Screening ...

Folic Acid: MedlinePlus Health Topic

Science.gov (United States)

... acid in diet (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Folic Acid updates ... acid - test Folic acid in diet Related Health Topics Vitamins National Institutes of Health The primary NIH ...

Pneumococcal Infections: MedlinePlus Health Topic

Science.gov (United States)

... Prevention, Immunization Action Coalition) - PDF Also in Spanish Topic Image MedlinePlus Email Updates Get Pneumococcal Infections updates ... ray Meningitis - pneumococcal Sputum gram stain Related Health Topics Meningitis Pneumonia Sepsis Sinusitis Streptococcal Infections National Institutes ...

Wilms' Tumor: MedlinePlus Health Topic

Science.gov (United States)

... Spanish Wilms tumor (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Wilms Tumor updates ... ENCYCLOPEDIA After chemotherapy - discharge Wilms tumor Related Health Topics Kidney Cancer National Institutes of Health The primary ...

Child Safety: MedlinePlus Health Topic

Science.gov (United States)

... injuries in children (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Child Safety updates ... safety Preventing head injuries in children Related Health Topics Infant and Newborn Care Internet Safety Motor Vehicle ...

Pneumocystis Infections: MedlinePlus Health Topic

Science.gov (United States)

... Pneumocystis jiroveci pneumonia (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Pneumocystis Infections updates ... GO MEDICAL ENCYCLOPEDIA Pneumocystis jiroveci pneumonia Related Health Topics HIV/AIDS HIV/AIDS and Infections Pneumonia National ...

Collapsed Lung: MedlinePlus Health Topic

Science.gov (United States)

... Spanish Pneumothorax - infants (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Collapsed Lung updates ... Lung surgery Pneumothorax - slideshow Pneumothorax - infants Related Health Topics Chest Injuries and Disorders Lung Diseases Pleural Disorders ...

Male Infertility: MedlinePlus Health Topic

Science.gov (United States)

... Spanish Testicular biopsy (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Male Infertility updates ... analysis Sperm release pathway Testicular biopsy Related Health Topics Assisted Reproductive Technology Female Infertility Infertility National Institutes ...

Healthy Aging: MedlinePlus Health Topic

Science.gov (United States)

... Aging National Institute on Aging Also in Spanish Topic Image MedlinePlus Email Updates Get Healthy Aging updates ... 65 Health screening - women - over 65 Related Health Topics Exercise for Seniors Nutrition for Seniors Seniors' Health ...

Hip Replacement: MedlinePlus Health Topic

Science.gov (United States)

... invasive hip replacement (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Hip Replacement updates ... replacement - precautions Minimally invasive hip replacement Related Health Topics Hip Injuries and Disorders National Institutes of Health ...

Platelet Disorders: MedlinePlus Health Topic

Science.gov (United States)

... Thromobocytopenia - drug-induced (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Platelet Disorders updates ... Willebrand disease Show More Show Less Related Health Topics Bleeding Disorders Blood Clots Blood Count Tests Blood ...

Cardiac Rehabilitation: MedlinePlus Health Topic

Science.gov (United States)

... in Spanish Electrocardiogram (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Cardiac Rehabilitation updates ... How to take your pulse Pulse Related Health Topics Heart Attack Heart Diseases How to Prevent Heart ...

Kawasaki Disease: MedlinePlus Health Topic

Science.gov (United States)

... Spanish Kawasaki disease (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Kawasaki Disease updates ... GO MEDICAL ENCYCLOPEDIA Electrocardiogram Kawasaki disease Related Health Topics Vasculitis National Institutes of Health The primary NIH ...

Diabetic Diet: MedlinePlus Health Topic

Science.gov (United States)

... Sweeteners - sugar substitutes (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Diabetic Diet updates ... you have diabetes Sweeteners - sugar substitutes Related Health Topics Blood Sugar Diabetes Diabetes in Children and Teens ...

Infection Control: MedlinePlus Health Topic

Science.gov (United States)

... Staph infections - hospital (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Infection Control updates ... infections when visiting Staph infections - hospital Related Health Topics Hepatitis HIV/AIDS MRSA National Institutes of Health ...

Hearing Aids: MedlinePlus Health Topic

Science.gov (United States)

... for hearing loss (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Hearing Aids updates ... MEDICAL ENCYCLOPEDIA Devices for hearing loss Related Health Topics Cochlear Implants Hearing Disorders and Deafness National Institutes ...

Kidney Tests: MedlinePlus Health Topic

Science.gov (United States)

... Spanish Total protein (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Kidney Tests updates ... hour volume Show More Show Less Related Health Topics Kidney Cancer Kidney Diseases National Institutes of Health ...

Ischemic Stroke: MedlinePlus Health Topic

Science.gov (United States)

... Spanish Thrombolytic therapy (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Ischemic Stroke updates ... cardiogenic embolism Stroke - slideshow Thrombolytic therapy Related Health Topics Hemorrhagic Stroke Stroke Stroke Rehabilitation National Institutes of ...

PREFACE: Second Meeting of the APS Topical Group on Hadronic Physics

Science.gov (United States)

Ernst, David; de Jager, Kees; Roberts, Craig; Sheldon, Paul; Swanson, Eric

2007-06-01

The Second Meeting of the APS Topical Group on Hadronic Physics was held on 22-24 October 2006 at the Opryland Resort in Nashville, Tennessee. Keeping with tradition, the meeting was held in conjunction with the Fall meeting of the APS Division of Nuclear Physics. Approximately 90 physicists participated in the meeting, presenting 25 talks in seven plenary sessions and 48 talks in 11 parallel sessions. These sessions covered a wide range of topics related to strongly interacting matter. Among these were charm spectroscopy, gluonic exotics, nucleon resonance physics, RHIC physics, electroweak and spin physics, lattice QCD initiatives, and new facilities. Brad Tippens and Brad Keister provided perspective from the funding agencies. The organisers are extremely grateful to the following institutions for financial and logistical support: the American Physical Society, Jefferson Lab, Brookhaven National Laboratory, and Vanderbilt University. We thank the following persons for assisting in organising the parallel sessions: Ted Barnes, Jian-Ping Chen, Ed Kinney, Krishna Kumar, Harry Lee, Mike Leitch, Kam Seth, and Dennis Weygand. We also thank Gerald Ragghianti for designing the conference poster, Will Johns for managing the audio-visual equipment and for placing the talks on the web, Sandy Childress for administrative expertise, and Vanderbilt graduate students Eduardo Luiggi and Jesus Escamillad for their assistance. David Ernst, Kees de Jager, Craig Roberts (Chair), Paul Sheldon and Eric Swanson Editors

Branched polynomial covering maps

DEFF Research Database (Denmark)

Hansen, Vagn Lundsgaard

1999-01-01

A Weierstrass polynomial with multiple roots in certain points leads to a branched covering map. With this as the guiding example, we formally define and study the notion of a branched polynomial covering map. We shall prove that many finite covering maps are polynomial outside a discrete branch...... set. Particular studies are made of branched polynomial covering maps arising from Riemann surfaces and from knots in the 3-sphere....

Antibiotic Resistance: MedlinePlus Health Topic

Science.gov (United States)

... GO GO About MedlinePlus Site Map FAQs Customer Support Health Topics Drugs & Supplements Videos & Tools Español You Are Here: Home → Health Topics → Antibiotic Resistance URL of this page: https://medlineplus.gov/antibioticresistance. ...

Topics in algebra and analysis preparing for the mathematical olympiad

CERN Document Server

Bulajich Manfrino, Radmila; Valdez Delgado, Rogelio

2015-01-01

The techniques presented here are useful for solving mathematical contest problems in algebra and analysis. Most of the examples and exercises that appear in the book originate from mathematical Olympiad competitions around the world. In the first four chapters the authors cover material for competitions at high school level. The level advances with the chapters. The topics explored include polynomials, functional equations, sequences and an elementary treatment of complex numbers. The final chapters provide a comprehensive list of problems posed at national and international contests in recent years, and solutions to all exercises and problems presented in the book. It helps students in preparing for national and international mathematical contests form high school level to more advanced competitions and will also be useful for their first year of mathematical studies at the university. It will be of interest to teachers in college and university level, and trainers of the mathematical Olympiads.

Mean species cover: a harmonized indicator of shrub cover for forest inventories

Science.gov (United States)

Iciar Alberdi; Sonia Condés; Ronald E. Mcroberts; Susanne Winter

2018-01-01

Because shrub cover is related to many forest ecosystem functions, it is one of the most relevant variables for describing these communities. Nevertheless, a harmonized indicator of shrub cover for large-scale reporting is lacking. The aims of the study were threefold: to define a shrub indicator that can be used by European countries for harmonized shrub cover...

Large-Scale Topic Detection and Language Model Adaptation

National Research Council Canada - National Science Library

Seymore, Kristie

1997-01-01

.... We have developed a language model adaptation scheme that takes apiece of text, chooses the most similar topic clusters from a set of over 5000 elemental topics, and uses topic specific language...

Quantum mechanics II advanced topics

CERN Document Server

Rajasekar, S

2015-01-01

Quantum Mechanics II: Advanced Topics uses more than a decade of research and the authors’ own teaching experience to expound on some of the more advanced topics and current research in quantum mechanics. A follow-up to the authors introductory book Quantum Mechanics I: The Fundamentals, this book begins with a chapter on quantum field theory, and goes on to present basic principles, key features, and applications. It outlines recent quantum technologies and phenomena, and introduces growing topics of interest in quantum mechanics. The authors describe promising applications that include ghost imaging, detection of weak amplitude objects, entangled two-photon microscopy, detection of small displacements, lithography, metrology, and teleportation of optical images. They also present worked-out examples and provide numerous problems at the end of each chapter.

Topical application of hemostatic paste

Directory of Open Access Journals (Sweden)

Mohammad Mizanur Rahman

2017-02-01

Full Text Available As a measure to control minor surgical bleeding, surgeons usually depend on a number of hemostatic aids. Topical use of bovine thrombin is a widely used procedure to arrest such minor bleeding. A 35 year old male sergeant of Bangladesh Air Force presented with repeated development of hematoma in his left thigh without any history of trauma or previous history of bleeding. Critical analysis of the patient’s history, routine and sophisticated hematological investigations revealed that the patient developed anti-thrombin antibody following the application of hemostatic paste in the tooth socket five years back during minor dental procedure to stop ignorable bleeding episodes. Therefore, topical use of hemostatic glue/paste or bovine thrombin should be avoided to desist minor bleeding as recombinant human thrombin is now available for topical use.

Topical, geospatial, and temporal diffusion of the 2015 North American Menopause Society position statement on nonhormonal management of vasomotor symptoms.

Science.gov (United States)

Carpenter, Janet S; Laine, Tei; Harrison, Blake; LePage, Meghan; Pierce, Taran; Hoteling, Nathan; Börner, Katy

2017-10-01

We sought to depict the topical, geospatial, and temporal diffusion of the 2015 North American Menopause Society position statement on the nonhormonal management of menopause-associated vasomotor symptoms released on September 21, 2015, and its associated press release from September 23, 2015. Three data sources were used: online news articles, National Public Radio, and Twitter. For topical diffusion, we compared keywords and their frequencies among the position statement, press release, and online news articles. We also created a network figure depicting relationships across key content categories or nodes. For geospatial diffusion within the United States, we compared locations of the 109 National Public Radio (NPR) stations covering the statement to 775 NPR stations not covering the statement. For temporal diffusion, we normalized and segmented Twitter data into periods before and after the press release (September 12, 2015 to September 22, 2015 vs September 23, 2015 to October 3, 2015) and conducted a burst analysis to identify changes in tweets from before to after. Topical information diffused across sources was similar with the exception of the more scientific terms "vasomotor symptoms" or "vms" versus the more colloquial term "hot flashes." Online news articles indicated media coverage of the statement was mainly concentrated in the United States. NPR station data showed similar proportions of stations airing the story across the four census regions (Northeast, Midwest, south, west; P = 0.649). Release of the statement coincided with bursts in the menopause conversation on Twitter. The findings of this study may be useful for directing the development and dissemination of future North American Menopause Society position statements and/or press releases.

Aerodynamics of wind turbines emerging topics

CERN Document Server

Amano, R S

2014-01-01

Focusing on Aerodynamics of Wind Turbines with topics ranging from Fundamental to Application of horizontal axis wind turbines, this book presents advanced topics including: Basic Theory for Wind turbine Blade Aerodynamics, Computational Methods, and Special Structural Reinforcement Technique for Wind Turbine Blades.

Affinity between information retrieval system and search topic

International Nuclear Information System (INIS)

Ebinuma, Yukio

1979-01-01

Ten search profiles are tested on the INIS system at the Japan Atomic Energy Research Institute. The results are plotted on recall-precision chart ranging from 100% recall to 100% precision. The curves are not purely systems-dependent nor search-dependent, and are determined substantially by the ''affinity'' between the system and the search topic. The curves are named ''Affinity curves of search topics with information retrieval systems'', and hence retrieval affinity factors are derived. They are obtained not only for individual search topics but also for averages in the system. By such a quantitative examination, the difference of affinity among search topics in a given system, that of the same search topic among various systems, and that of systems to the same group of search topics can be compared reasonably. (author)

Analyzing the history of Cognition using Topic Models.

Science.gov (United States)

Cohen Priva, Uriel; Austerweil, Joseph L

2015-02-01

Very few articles have analyzed how cognitive science as a field has changed over the last six decades. We explore how Cognition changed over the last four decades using Topic Models. Topic Models assume that every word in every document is generated by one of a limited number of topics. Words that are likely to co-occur are likely to be generated by a single topic. We find a number of significant historical trends: the rise of moral cognition, eyetracking methods, and action, the fall of sentence processing, and the stability of development. We introduce the notion of framing topics, which frame content, rather than present the content itself. These framing topics suggest that over time Cognition turned from abstract theorizing to more experimental approaches. Copyright © 2014 Elsevier B.V. All rights reserved.

EXAMINING COMFORT PROPERTIES OF LEATHER and ARTIFICIAL LEATHER COVER MATERIALS

Directory of Open Access Journals (Sweden)

ÇETİN Münire Sibel

2016-05-01

Full Text Available The analysis and regulation of workplace, working instruments, the comfort of office chair, business environment (sound, lighting, climate, vibration, temperature, and humidity, work and break times, analysis and editing of the organization, are some of the topics of interest of ergonomics. Environmental impact and conditions have important role on the employee’s working comfortably and efficiently. Therefore these conditions need to be aligned to the human body nature. Unsuitable working conditions (noise, etc. cause additional load, which the human body endures, and this additional load reveals the signs of tiredness in the body. Even an office environment, unsuitable physical environment impairs health of workers and reduces the performance. Therefore, office climate, environmental factors such as lighting and noise must be harmonized with the employee’s body nature in all working environments. Seating comfort is one of the important factors affecting the performance of employees in the office environment. There are so many studies about chair dimensions and the disorders on human body which were caused by the inappropriate chair dimensions and sitting positions. However, there are a spot of studies about the surface of the chair and the discomfort caused by the chair cover and its negative performance effects. In this study, some results of seat cover analysis for the design of an ergonomic chair. Recently, ease of cleaning, low cost advantages caused the increasing of the use of artificial leather especially on the surface of the seat used in offices. The physical properties of natural leather and artificial leather were compared as the candidate covers to be used on the design of an ergonomic office chair.

Updates of Topical and Local Anesthesia Agents.

Science.gov (United States)

Boyce, Ricardo A; Kirpalani, Tarun; Mohan, Naveen

2016-04-01

As described in this article, there are many advances in topical and local anesthesia. Topical and local anesthetics have played a great role in dentistry in alleviating the fears of patients, eliminating pain, and providing pain control. Many invasive procedures would not be performed without the use and advances of topical/local anesthetics. The modern-day dentist has the responsibility of knowing the variety of products on the market and should have at least references to access before, during, and after treatment. This practice ensures proper care with topical and local anesthetics for the masses of patients entering dental offices worldwide. Copyright © 2016 Elsevier Inc. All rights reserved.

Land-cover change detection

Science.gov (United States)

Chen, Xuexia; Giri, Chandra; Vogelmann, James

2012-01-01

Land cover is the biophysical material on the surface of the earth. Land-cover types include grass, shrubs, trees, barren, water, and man-made features. Land cover changes continuously.  The rate of change can be either dramatic and abrupt, such as the changes caused by logging, hurricanes and fire, or subtle and gradual, such as regeneration of forests and damage caused by insects (Verbesselt et al., 2001).  Previous studies have shown that land cover has changed dramatically during the past sevearal centuries and that these changes have severely affected our ecosystems (Foody, 2010; Lambin et al., 2001). Lambin and Strahlers (1994b) summarized five types of cause for land-cover changes: (1) long-term natural changes in climate conditions, (2) geomorphological and ecological processes, (3) human-induced alterations of vegetation cover and landscapes, (4) interannual climate variability, and (5) human-induced greenhouse effect.  Tools and techniques are needed to detect, describe, and predict these changes to facilitate sustainable management of natural resources.

Anesthesia: A Topic for Interdisciplinary Study.

Science.gov (United States)

Labianca, Dominick A.; Reeves, William J.

1977-01-01

Describes an interdisciplinary approach for teaching the topic of anesthesia as one aspect of a chemistry-oriented course for nonscience majors which focuses on timely topics such as the energy crisis and drugs. Historical treatment with the examination of literature is emphasized in teaching. (HM)

Efficacy, tolerability and consumer acceptability of terbinafine topical spray versus terbinafine topical solution: a phase IIa, randomised, observer-blind, comparative study.

Science.gov (United States)

Brown, Marc; Evans, Charles; Muddle, Andrew; Turner, Rob; Lim, Sian; Reed, Jessica; Traynor, Matt

2013-10-01

Tinea pedis is one of the world's most prevalent dermatophyte infections. MedSpray™ tinea pedis 1 % w/w (topical spray) is a novel, easy-to-use propellant-based spray formulation containing 1 % w/w terbinafine, requiring no manipulation at the site of infection. This is in contrast to the only formulation currently approved in Europe for single application (none are approved in the USA for single use), which is Lamisil(®) Once 1 % w/w (topical solution), containing 1 % w/w terbinafine hydrochloride, which requires manipulation on the affected area. The aim of this study was to evaluate the efficacy, tolerability and consumer acceptability of a topical spray versus a topical solution in the treatment of tinea pedis. This study is a phase IIa, randomised, observer-blind, non-inferiority comparative study of the topical spray compared with the topical solution over a 12-week study period. The study was conducted at Bioskin GmbH, Hamburg and Berlin. Patients (n = 120) who presented with the presence of interdigital tinea pedis caused by dermatophytes on one or both feet were enrolled in the study. Patients were randomly assigned between the two treatment groups. Either the topical spray or the topical solution was administered by the study nurse and consisted of a single application (equivalent to 20 mg of terbinafine per foot) on day 1 of the study. No further applications were made for the duration of the study. The hypothesis formulated before commencement of the study was that the topical spray would prove to be non-inferior to the topical solution. Efficacy assessments, including clinical signs and symptoms, mycology and microscopy were performed at baseline and 1, 6 and 12 weeks after treatment. The rate of mycological cure at week 1 was statistically equivalent for both treatments. There was a significant reduction in the overall clinical score as assessed by the Physician's Global Assessment of signs and symptoms for both treatment groups. The topical

Mathematical modelling of water and gas transport in layered soil covers for coal ash deposit

Energy Technology Data Exchange (ETDEWEB)

Lindgren, M [Kemakta Consultants Co, Stockholm (SE); Rasmuson, A [Chalmers University of Technology, Goeteborg (SE). Dept. of Chemical Engineering Design

1991-06-19

In phase 1 of this study the design of soil covers for deposits of coal ash from energy production was studied with regard to various parameters like: climate, cover slope, hydraulic conductivity of tight layer and length of cover. One of the main results was the relatively large risk for total saturation up to the surface and overflow which may cause surface erosion problems. In the present study two theoretical cases are studied to further elucidate the problem. A case from the phase 1 study is used to illustrate the effect of increased infiltration. Calculations show that total saturation and thereby overflow is achieved when the infiltration is increased by 20% in March, but not when increased by 10% only. This shows that the margin in an acceptable case may be small. A cover treated in phase 1, where totally saturated conditions were obtained, was modified so that two decimeters of the one meter till in its bottom part were exchanged for a drainage layer. It is shown that the effect of this layer is large. A negative side-effect, however, is that gas flow may increase due to the lower saturation of the cover. Calculations were made for a real soil covered mine tailings deposit at Bersbo. This deposit was chosen mainly because it is the only well documented case in Sweden where soil covers are used for securing a deposit, but also because some contradictory results as compared to theory were obtained. Another topic studied in the present work was the influence of a heterogeneous clay layer. For example, a weak zone with a hydraulic conductivity of 10{sup -7} m/s (10{sup -9} m/s for the rest of the clay), covering 0.5 m x 0.5 m of 10 m in length and 5 m in width, will increase the flow through the bottom of the cover with almost 30%. The gas transport through the heterogeneous soil cover was also studied, showing about 5 times increased gas transport rate around the weak zone, but almost no difference about 1 m from the weak zone. (29 figs., 5 tabs., 27 refs.).

Topical thrombin-related corneal calcification.

Science.gov (United States)

Kiratli, Hayyam; Irkeç, Murat; Alaçal, Sibel; Söylemezoğlu, Figen

2006-09-01

To report a highly unusual case of corneal calcification after brief intraoperative use of topical thrombin. A 44-year-old man underwent sclerouvectomy for ciliochoroidal leiomyoma, during which 35 UNIH/mL lyophilized bovine thrombin mixed with 9 mL of diluent containing 1500 mmol/mL calcium chloride was used. From the first postoperative day, corneal and anterior lenticular capsule calcifications developed, and corneal involvement slightly enlarged thereafter. A year later, 2 corneal punch biopsies confirmed calcification mainly in the Bowman layer. Topical treatment with 1.5% ethylenediaminetetraacetic acid significantly restored corneal clarity. Six months later, a standard extracapsular cataract extraction with intraocular lens placement improved visual acuity to 20/60. This case suggests that topical thrombin drops with elevated calcium concentrations may cause acute corneal calcification in Bowman layer and on the anterior lens capsule.

Topics in the Journal of Counseling Psychology, 1963-2015.

Science.gov (United States)

Oh, JungSu; Stewart, Alan E; Phelps, Rosemary E

2017-11-01

Historical trends in a scientific field should be apparent in the changing content of journal articles over time. Using a topic modeling approach, a statistical method for quantifying the thematic content of text, 70 topics were extracted from the abstracts of 3,603 articles published in the Journal of Counseling Psychology from 1963 to 2015. After examining interpretability of 70 topics derived from the model, 64 meaningful topics and their trends were named. In addition, the authors also classified some of the related topics into 4 categories-counseling process and outcome, multiculturalism, research methodology, and vocational psychology. Counseling process and outcome related topics have decreased recently, while topics relating to multiculturalism and diversity have shown increasing trends. The authors also discussed trends that were observed and tried to account for the changing frequencies of some important research topics within these categories. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Influence of number of topics, topic duration, and curricular focus on biology achievement of Population 3 TIMSS countries

Science.gov (United States)

Hodges, Eddie Louis

The purposes of this study were to determine if a relationship exists between biology achievement and (1) number of topics, (2) topic duration, (3) curricular focus, and (4) science achievement using TIMSS data from Population 3---the final year of secondary school. Students included in this study were subsets of the 55,675 students from 22 countries who participated in the science literacy portion of TIMSS at the Population 3 level (IEA, 1997). The sample included in this study for the four research questions were comprised of between (1) 17,769 and 37,794 students from 15 countries, (2) 17,769 and 37,794 students from 15 countries, (3) 21,715 and 46,458 students from 18 countries, and (4) 19,518 and 46,458 students from 18 countries, respectively. A Pearson's product moment correlation was used to determine whether a relationship exists between the number of biology topics addressed by intended national science curricula and mean student achievement on selected items by country. No statistically significant correlation was found by country between biology achievement and number of topics. To determine whether a relationship exists between the topic duration of biology topics addressed by released, biology-oriented, Population 3 Science Literacy items and student achievement on those items, a Pearson's product moment correlation was also used. A statistically significant correlation between biology achievement and topic duration for only one topic (Interdependence of Life) was found at the .05 level of significance. A possible relationship between the degree of curricular focus of Population 3 TIMSS countries and student achievement on selected items by country was evaluated using a Pearson's product moment correlation. No statistically significant correlation by country between biology achievement and degree of curricular focus was found. A Pearson's product moment correlation was used to determine whether a relationship exists between science literacy

Extracting Hot spots of Topics from Time Stamped Documents

Science.gov (United States)

Chen, Wei; Chundi, Parvathi

2011-01-01

Identifying time periods with a burst of activities related to a topic has been an important problem in analyzing time-stamped documents. In this paper, we propose an approach to extract a hot spot of a given topic in a time-stamped document set. Topics can be basic, containing a simple list of keywords, or complex. Logical relationships such as and, or, and not are used to build complex topics from basic topics. A concept of presence measure of a topic based on fuzzy set theory is introduced to compute the amount of information related to the topic in the document set. Each interval in the time period of the document set is associated with a numeric value which we call the discrepancy score. A high discrepancy score indicates that the documents in the time interval are more focused on the topic than those outside of the time interval. A hot spot of a given topic is defined as a time interval with the highest discrepancy score. We first describe a naive implementation for extracting hot spots. We then construct an algorithm called EHE (Efficient Hot Spot Extraction) using several efficient strategies to improve performance. We also introduce the notion of a topic DAG to facilitate an efficient computation of presence measures of complex topics. The proposed approach is illustrated by several experiments on a subset of the TDT-Pilot Corpus and DBLP conference data set. The experiments show that the proposed EHE algorithm significantly outperforms the naive one, and the extracted hot spots of given topics are meaningful. PMID:21765568

Vesiculo-erosive oral mucosal disease--management with topical corticosteroids: (1) Fundamental principles and specific agents available.

Science.gov (United States)

González-Moles, M A; Scully, C

2005-04-01

Vesiculo-erosive diseases of the oral mucosa pose a major challenge in oral medicine, because they are chronic, painful, and interfere with the daily activities and quality of life of the patients, including disturbing eating, drinking, talking, and personal relationships. Many are autoimmune diseases, and corticosteroid therapy is currently central to their treatment. These diseases present with inflammation and alterations to epithelial integrity, through cell and/or humoral immunity-mediated attack on epithelial-connective tissue targets. Until recently, despite their serious adverse effects, it was necessary to prescribe systemic corticosteroids to control severe erosive oral diseases. Now, however, many of these diseases can be controlled by high-potency topical corticosteroids, which have proved to be highly efficacious and to cause fewer adverse effects compared with systemic corticosteroids. Nevertheless, although topical corticosteroids are still the most widely used drugs in the practice of oral medicine, the scientific body of evidence for their use in the oral cavity is virtually non-existent, and therefore many of the protocols followed are, of necessity, drawn from experience of their use in a dermatological setting. This review aims to set out the key aspects of the use of topical corticosteroids in oral medicine. The issues covered include the indications and basic rules for their use, the types of corticosteroids, the drug selection, and the specific formulations.

The Concept of the Interculture in Time: (Intercultural Topics in Textbooks of French as a Foreign Language

Directory of Open Access Journals (Sweden)

Meta Lah

2012-12-01

Full Text Available The article deals with the concept of interculturality as used in foreign language didactics. In accordance with the definition of interculturality given in the first part of the article, two categories are included in the analysis – two “levels” of culture, each of them bearing a different name in literature, namely high and popular culture. Various textbooks used for teaching French as a foreign language in Slovenia in both the past and present were chosen for the analysis of topics that cover a fairly long period of time – among them the textbooks by two Slovenian authors: Južnič (1938 and Grad (1954, as well as some generally-used French textbooks, such as Cours de langue et de civilisation françaises (1953, Le nouveau sans frontières (1988 and Nouveau rond point (2011. The article is based on the hypothesis that high culture is more likely to be present in the older textbooks, which are based on traditional methods, whereas in modern textbooks more popular, everyday topics can be found. It is also presumed that topics in modern textbooks are, compared to their more traditional counterparts, introduced in an intercultural manner which could encourage students to compare the culture of the foreign country with their own. Both hypotheses are partly confirmed. In Slovenian textbooks there are very few culture-based topics. On the other hand, they are present in all French textbooks, regardless of the methodology. It is true that Mauger introduces more high culture than the others and that the intercultural topics are presented only in the most recent textbook. In all the others, it is exclusively the culture of the target country that is introduced.

Effects of three types of lecture notes on medical student achievement.

Science.gov (United States)

Russell, I J; Caris, T N; Harris, G D; Hendricson, W D

1983-08-01

Two parallel studies were conducted with junior medical students to determine what influence the forms of lecture notes would have on learning. The three types of notes given to the students were: a comprehensive manuscript of the lecture containing text, tables, and figures; a partial handout which included some illustrations but required substantial annotation by the students; and a skeleton outline containing no data from the lecture. The students' knowledge about the subject was measured before the lecture, immediately after the lecture, two to four weeks later, and approximately three months later. The students' responses to questionnaires indicated a strong preference for very detained handouts as essential to preparation for examinations. By contract, the students' performances on tests generally were better for those who had received the partial or skeleton handout formats. This was particularly true for information presented during the last quarter of each lecture, when learning efficiency of the skeleton handout group increased while the other two handout groups exhibited learning fatigue. It was concluded that learning by medical students was improved when they recorded notes in class.

Topics in modern differential geometry

CERN Document Server

Verstraelen, Leopold

2017-01-01

A variety of introductory articles is provided on a wide range of topics, including variational problems on curves and surfaces with anisotropic curvature. Experts in the fields of Riemannian, Lorentzian and contact geometry present state-of-the-art reviews of their topics. The contributions are written on a graduate level and contain extended bibliographies. The ten chapters are the result of various doctoral courses which were held in 2009 and 2010 at universities in Leuven, Serbia, Romania and Spain.

77 FR 48733 - Transitional Program for Covered Business Method Patents-Definitions of Covered Business Method...

Science.gov (United States)

2012-08-14

... Office 37 CFR Part 42 Transitional Program for Covered Business Method Patents--Definitions of Covered... Business Method Patents-- Definitions of Covered Business Method Patent and Technological Invention AGENCY... forth in detail the definitions of the terms ``covered business method patent'' and ``technological...

47{sup th} Annual meeting on nuclear technology (AMNT 2016). Key Topics / Enhanced safety and operation excellence and decommissioning experience and Waste management solutions

Energy Technology Data Exchange (ETDEWEB)

Salnikova, Tatiana [AREVA GmbH, Erlangen (Germany); Schaffrath, Andreas [Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) gGmbH, Garching (Germany)

2016-10-15

Summary report on the Key Topics ''Enhanced Safety and Operation Excellence'' and ''Decommissioning Experience and Waste Management Solutions'' of the 47{sup th} Annual Conference on Nuclear Technology (AMNT 2016) held in Hamburg, 10 to 12 May 2016. Other Sessions of AMNT 2016 have been and will be covered in further issues of atw.

Salicylic Acid Topical

Science.gov (United States)

... the package label for more information.Apply a small amount of the salicylic acid product to one or two small areas you want to treat for 3 days ... know that children and teenagers who have chicken pox or the flu should not use topical salicylic ...

Covering folded shapes

Directory of Open Access Journals (Sweden)

Oswin Aichholzer

2014-05-01

Full Text Available Can folding a piece of paper flat make it larger? We explore whether a shape S must be scaled to cover a flat-folded copy of itself. We consider both single folds and arbitrary folds (continuous piecewise isometries \\(S\\to\\mathbb{R}^2\\. The underlying problem is motivated by computational origami, and is related to other covering and fixturing problems, such as Lebesgue's universal cover problem and force closure grasps. In addition to considering special shapes (squares, equilateral triangles, polygons and disks, we give upper and lower bounds on scale factors for single folds of convex objects and arbitrary folds of simply connected objects.

Topical report review status. Volume 9, No. 1

International Nuclear Information System (INIS)

1995-02-01

This report provides industry with procedures for submitting topical reports, guidance on how the US Nuclear Regulatory Commission (NRC) processes and responds to topical report submittals, and an accounting, with review schedules, of all topical reports currently accepted for review by the NRC. This report is published semiannually

Land cover change detection using the internal covariance matrix of the extended kalman filter over multiple spectral bands

CSIR Research Space (South Africa)

Salmon

2013-06-01

Full Text Available stream_source_info Salmon_10577_2013.pdf.txt stream_content_type text/plain stream_size 1183 Content-Encoding ISO-8859-1 stream_name Salmon_10577_2013.pdf.txt Content-Type text/plain; charset=ISO-8859-1 IEEE Journal... of Selected Topics in Applied Earth Observations and Remote Sensing, vol, 6(3): 1079- 1085 Land cover change detection using the internal covariance matrix of the extended kalman filter over multiple spectral bands Salmon BP Kleynhans W Van den Bergh...

Evaluation of SLAR and simulated thematic mapper MSS data for forest cover mapping using computer-aided analysis techniques

Science.gov (United States)

Hoffer, R. M.; Dean, M. E.; Knowlton, D. J.; Latty, R. S.

1982-01-01

Kershaw County, South Carolina was selected as the study site for analyzing simulated thematic mapper MSS data and dual-polarized X-band synthetic aperture radar (SAR) data. The impact of the improved spatial and spectral characteristics of the LANDSAT D thematic mapper data on computer aided analysis for forest cover type mapping was examined as well as the value of synthetic aperture radar data for differentiating forest and other cover types. The utility of pattern recognition techniques for analyzing SAR data was assessed. Topics covered include: (1) collection and of TMS and reference data; (2) reformatting, geometric and radiometric rectification, and spatial resolution degradation of TMS data; (3) development of training statistics and test data sets; (4) evaluation of different numbers and combinations of wavelength bands on classification performance; (5) comparison among three classification algorithms; and (6) the effectiveness of the principal component transformation in data analysis. The collection, digitization, reformatting, and geometric adjustment of SAR data are also discussed. Image interpretation results and classification results are presented.

Land cover and water yield: inference problems when comparing catchments with mixed land cover

Directory of Open Access Journals (Sweden)

A. I. J. M. van Dijk

2012-09-01

Full Text Available Controlled experiments provide strong evidence that changing land cover (e.g. deforestation or afforestation can affect mean catchment streamflow (Q. By contrast, a similarly strong influence has not been found in studies that interpret Q from multiple catchments with mixed land cover. One possible reason is that there are methodological issues with the way in which the Budyko framework was used in the latter type studies. We examined this using Q data observed in 278 Australian catchments and by making inferences from synthetic Q data simulated by a hydrological process model (the Australian Water Resources Assessment system Landscape model. The previous contrasting findings could be reproduced. In the synthetic experiment, the land cover influence was still present but not accurately detected with the Budyko- framework. Likely sources of interpretation bias demonstrated include: (i noise in land cover, precipitation and Q data; (ii additional catchment climate characteristics more important than land cover; and (iii covariance between Q and catchment attributes. These methodological issues caution against the use of a Budyko framework to quantify a land cover influence in Q data from mixed land-cover catchments. Importantly, however, our findings do not rule out that there may also be physical processes that modify the influence of land cover in mixed land-cover catchments. Process model simulations suggested that lateral water redistribution between vegetation types and recirculation of intercepted rainfall may be important.

Topical treatment of psoriasis: questionnaire results on topical therapy accessibility and influence of body surface area on usage

NARCIS (Netherlands)

Iversen, L.; Lange, M.M. De; Bissonette, R.; Carvalho, A.V.E.; Kerkhof, P.C.M. van de; Kirby, B.; Kleyn, C.E.; Lynde, C.W.; Walt, J.M. van der; Wu, J.J.

2017-01-01

BACKGROUND: Topical treatment of mild to moderate psoriasis is first-line treatment and exhibits varying degrees of success across patient groups. Key factors influencing treatment success are physician topical treatment choice (high efficacy, low adverse events) and strict patient adherence.

Hot topics: Signal processing in acoustics

Science.gov (United States)

Gaumond, Charles F.

2005-09-01

Signal processing in acoustics is a multidisciplinary group of people that work in many areas of acoustics. We have chosen two areas that have shown exciting new applications of signal processing to acoustics or have shown exciting and important results from the use of signal processing. In this session, two hot topics are shown: the use of noiselike acoustic fields to determine sound propagation structure and the use of localization to determine animal behaviors. The first topic shows the application of correlation on geo-acoustic fields to determine the Greens function for propagation through the Earth. These results can then be further used to solve geo-acoustic inverse problems. The first topic also shows the application of correlation using oceanic noise fields to determine the Greens function through the ocean. These results also have utility for oceanic inverse problems. The second topic shows exciting results from the detection, localization, and tracking of marine mammals by two different groups. Results from detection and localization of bullfrogs are shown, too. Each of these studies contributed to the knowledge of animal behavior. [Work supported by ONR.

Topical Valproate Solution for Hair Growth

Directory of Open Access Journals (Sweden)

Anil Kakunje

2018-05-01

Full Text Available Valproate is used regularly in the treatment of various seizure disorders, bipolar disorder, migraine prophylaxis and off label in many other conditions. Alopecia or hair loss is cosmetic side effect of oral valproate administration. Hair loss with valproate is diffused, non-scarring and dose related. A large number of drugs may interfere with the hair cycle and produce hair loss. We have only a few drugs like Minoxidil, Finasteride used for hair regeneration and both have its own side effects and limitations. In contrast to oral ingestions of valproate causing hair loss, early experiments with topical Valproic acid cream showed hair regeneration. Valproic acid cream is currently unavailable in the market, alternatively, we do have valproate and divalproex solutions available in various strengths which have a potential to be used topically for hair regeneration. The side effects and cost of topical valproate solution could be much less than the available options in the market. Valproate solution topically has the potential to be used for hair growth.

Skin graft fixation in severe burns: use of topical negative pressure.

Science.gov (United States)

Kamolz, L P; Lumenta, D B; Parvizi, D; Wiedner, M; Justich, I; Keck, M; Pfurtscheller, K; Schintler, M

2014-09-30

Over the last 50 years, the evolution of burn care has led to a significant decrease in mortality. The biggest impact on survival has been the change in the approach to burn surgery. Early excision and grafting has become a standard of care for the majority of patients with deep burns; the survival of a given patient suffering from major burns is invariably linked to the take rate and survival of skin grafts. The application of topical negative pressure (TNP) therapy devices has demonstrated improved graft take in comparison to conventional dressing methods alone. The aim of this study was to analyze the impact of TNP therapy on skin graft fixation in large burns. In all patients, we applied TNP dressings covering a %TBSA of >25. The following parameters were recorded and documented using BurnCase 3D: age, gender, %TBSA, burn depth, hospital length-of-stay, Baux score, survival, as well as duration and incidence of TNP dressings. After a burn depth adapted wound debridement, coverage was simultaneously performed using split-thickness skin grafts, which were fixed with staples and covered with fatty gauzes and TNP foam. The TNP foam was again fixed with staples to prevent displacement and finally covered with the supplied transparent adhesive film. A continuous subatmospheric pressure between 75-120 mm Hg was applied (VAC®, KCI, Vienna, Austria). The first dressing change was performed on day 4. Thirty-six out of 37 patients, suffering from full thickness burns, were discharged with complete wound closure; only one patient succumbed to their injuries. The overall skin graft take rate was over 95%. In conclusion, we consider that split thickness skin graft fixation by TNP is an efficient method in major burns, notably in areas with irregular wound surfaces or subject to movement (e.g. joint proximity), and is worth considering for the treatment of aged patients.

Evaluating topic model interpretability from a primary care physician perspective.

Science.gov (United States)

Arnold, Corey W; Oh, Andrea; Chen, Shawn; Speier, William

2016-02-01

Probabilistic topic models provide an unsupervised method for analyzing unstructured text. These models discover semantically coherent combinations of words (topics) that could be integrated in a clinical automatic summarization system for primary care physicians performing chart review. However, the human interpretability of topics discovered from clinical reports is unknown. Our objective is to assess the coherence of topics and their ability to represent the contents of clinical reports from a primary care physician's point of view. Three latent Dirichlet allocation models (50 topics, 100 topics, and 150 topics) were fit to a large collection of clinical reports. Topics were manually evaluated by primary care physicians and graduate students. Wilcoxon Signed-Rank Tests for Paired Samples were used to evaluate differences between different topic models, while differences in performance between students and primary care physicians (PCPs) were tested using Mann-Whitney U tests for each of the tasks. While the 150-topic model produced the best log likelihood, participants were most accurate at identifying words that did not belong in topics learned by the 100-topic model, suggesting that 100 topics provides better relative granularity of discovered semantic themes for the data set used in this study. Models were comparable in their ability to represent the contents of documents. Primary care physicians significantly outperformed students in both tasks. This work establishes a baseline of interpretability for topic models trained with clinical reports, and provides insights on the appropriateness of using topic models for informatics applications. Our results indicate that PCPs find discovered topics more coherent and representative of clinical reports relative to students, warranting further research into their use for automatic summarization. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Topics on continua

CERN Document Server

Macias, Sergio

2005-01-01

Specialized as it might be, continuum theory is one of the most intriguing areas in mathematics. However, despite being popular journal fare, few books have thoroughly explored this interesting aspect of topology. In Topics on Continua, Sergio Macías, one of the field's leading scholars, presents four of his favorite continuum topics: inverse limits, Jones's set function T, homogenous continua, and n-fold hyperspaces, and in doing so, presents the most complete set of theorems and proofs ever contained in a single topology volume. Many of the results presented have previously appeared only in research papers, and some appear here for the first time. After building the requisite background and exploring the inverse limits of continua, the discussions focus on Professor Jones''s set function T and continua for which T is continuous. An introduction to topological groups and group actions lead to a proof of Effros''s Theorem, followed by a presentation of two decomposition theorems. The author then offers an...

Resident education and perceptions of recovery in serious mental illness: observations and commentary.

Science.gov (United States)

Buckley, Peter; Bahmiller, Daniel; Kenna, Courtney Amanda; Shevitz, Stewart; Powell, Ike; Fricks, Larry

2007-01-01

Recovery is emerging as a guiding influence in mental health service delivery and transformation. As a consequence, the expectations and curricular needs of trainees (as future stakeholders in a transformed, recovery-oriented system) are now of considerable importance. To this end, resident-led focus groups were held at the Medical College of Georgia to obtain perceptions of the Recovery Model. Certified Peer Support Specialists (CPSS) attended and topics covered were the Recovery Model, the CPSS training curriculum, and developing a Wellness Recovery Action Plan (WRAP) with consumers. Advantages and disadvantages of the Recovery model were discussed, with residents generally expressing cautious optimism regarding implementation of these principles, yet concern regarding the potential for diminishing confidence and support for traditional professional services. All residents indicated an interest in obtaining more information about the Recovery Model, including how to incorporate WRAPS and the role of CPSS in Recovery. Almost half of the residents selected a recovery-oriented workshop as the best method for further education about these concepts, with less support for other options of didactic handouts and expert lecture. Future efforts should be directed at implementing recovery curricula into resident education and evaluating the changes in resident knowledge, attitude toward recovery, and plans to implement recovery-oriented principles into their own professional practice.

A Comparison of Motivation and the Process of Teaching in French Language Classes for Children and for Adults

Directory of Open Access Journals (Sweden)

Katarina Paternost

2013-12-01

Full Text Available Motivation of pupils and the question of how to motivate them seems to be the main issue of language teachers. As a French language teacher of both, children and adults, I have acquired quite some experiences in the past seven years of teaching in different language schools. These experiences are a great help in preparing my courses. However, as there is no established curricula in the language schools, which is quite a difference in comparison to public elementary and high schools, every teacher is expected to create his or her particular curriculum. This means literature, topics and matters that course will cover have to be selected by the teacher, and the teacher prepares all the handouts. If the level of satisfaction differs from the expectations of the pupils, they will most likely refuse to participate in the future. Because of that the question of motivation remains one of the main issues in terms of language teaching. The aim of the article is the comparison of the methods of raising motivation among the pupils I teach in two differentlanguage schools. The first group is mainly focused on children and the second group is focused on adults. Key words: motivation, course, grammar, reading comprehension, listening comprehension

Armored Geomembrane Cover Engineering

Directory of Open Access Journals (Sweden)

Kevin Foye

2011-06-01

Full Text Available Geomembranes are an important component of modern engineered barriers to prevent the infiltration of stormwater and runoff into contaminated soil and rock as well as waste containment facilities—a function generally described as a geomembrane cover. This paper presents a case history involving a novel implementation of a geomembrane cover system. Due to this novelty, the design engineers needed to assemble from disparate sources the design criteria for the engineering of the cover. This paper discusses the design methodologies assembled by the engineering team. This information will aid engineers designing similar cover systems as well as environmental and public health professionals selecting site improvements that involve infiltration barriers.

Carbon Monoxide Safety

Science.gov (United States)

... with the Media Fire Protection Technology Carbon monoxide safety outreach materials Keep your community informed about the ... KB | Spanish PDF 592 KB Handout: carbon monoxide safety Download this handout and add your organization's logo ...

Topical cholesterol in clofazimine induced ichthyosis

Directory of Open Access Journals (Sweden)

Pandey S

1994-01-01

Full Text Available Topical application of 10% cholesterol in petrolatum significantly (P< 0.05 controlled the development of ichthyosis in 62 patients taking 100 mg clofazimine daily for a period of 3 months. However, topical cholesterol application did not affect the lowering of serum cholesterol induced by oral clofazimine. Probable mechanism of action is being discussed.

Comparison of species-rich cover crop mixtures in Hungarian vineyards

Science.gov (United States)

Donkó, Adam; Miglécz, Tamas; Valkó, Orsolya; Török, Peter; Deák, Balazs; Kelemen, Andras; Zanathy, Gabor; Drexler, Dora

2014-05-01

, Plantago lanceolata, Trifolium pratense, Trifolium repens and Vicia sativa. We found that weed cover was lower in every treatment compared to the unsown control plots, thus, cover crops suppressed weeds of the inter-rows effectively. Most examined indices of grapevines were not significantly affected by the applied cover crop. However, the tendency of the results shows that in the drier climate of Hungary every second inter-row sowing is more preferable than consecutive cover-crop application, where erosion control is not essential. The opinion of the growers about the mixtures varied. The Biocont-Ecovin mixture was praised for its early aesthetic qualities, produced by Camelina sativa, Phacelia tanacetifolia and Sinapis alba. However, it was criticized for its non-native species, the foreign provenance of some seeds, and the height of the vegetation. The other two mixtures did not produce a spectacular flowering, but developed a lower canopy, and were praised for their native species content. Due to spring sowing the grass-herb mixture, containing a number of species with autumn germination, produced the lowest coverage among the tested mixtures in the first year. However, as predicted, it performed satisfactorily in the second year of the trial. The interest of the vine-growers underlines the importance of the topic for the Central-Eastern European region, thus further examination will be continued in 2014.

Topical antibiotic monotherapy prescribing practices in acne vulgaris.

Science.gov (United States)

Hoover, William D; Davis, Scott A; Fleischer, Alan B; Feldman, Steven R

2014-04-01

The aim of this study is to evaluate the frequency of dosing topical antibiotics as monotherapy in the treatment of acne vulgaris, and physician specialty prescribing these medications. This study is a retrospective review of all visits with a sole diagnosis of acne vulgaris (ICD-9-CM code 706.1) found on the National Ambulatory Medical Care Survey (NAMCS) in 1993-2010. We recorded the number of visits surveyed where acne vulgaris was the sole diagnosis, number of visits where topical antibiotics were the only treatment prescribed, and the specialty of physician in each encounter. Topical erythromycin or clindamycin were the sole medication prescribed in 0.81% of the visits recorded, with 60% of these prescriptions arising from dermatologists and 40% from non-dermatologists. The trend of prescribing topical antibiotic monotherapy is declining (p acnes to topical antibiotic regimens has led to the need to re-evaluate the use of topical antibiotics in the treatment of acne vulgaris. While the rate of topical antibiotic monotherapy is declining, their use should be reserved for situations where the direct need for antibiotics arises. If a clinician feels that antibiotics are a necessary component to acne therapy, they should be used as part of a combination regimen.

Baby Health Checkup: MedlinePlus Health Topic

Science.gov (United States)

... Know (Centers for Disease Control and Prevention) - PDF Topic Image MedlinePlus Email Updates Get Baby Health Checkup ... GO MEDICAL ENCYCLOPEDIA Well-child visits Related Health Topics Childhood Immunization Common Infant and Newborn Problems Infant ...

Laser Eye Surgery: MedlinePlus Health Topic

Science.gov (United States)

... corneal surgery - discharge (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Laser Eye Surgery ... surgery - what to ask your doctor Related Health Topics Refractive Errors National Institutes of Health The primary ...

Child Mental Health: MedlinePlus Health Topic

Science.gov (United States)

... events and children (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Child Mental Health ... in childhood Traumatic events and children Related Health Topics Bullying Child Behavior Disorders Mental Disorders Mental Health ...

Bone Marrow Transplantation: MedlinePlus Health Topic

Science.gov (United States)

... marrow transplant - discharge (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Bone Marrow Transplantation ... transplant - slideshow Graft-versus-host disease Related Health Topics Bone Marrow Diseases Stem Cells National Institutes of ...

Nutrition for Seniors: MedlinePlus Health Topic

Science.gov (United States)

... America) National Institute on Aging Also in Spanish Topic Image MedlinePlus Email Updates Get Nutrition for Seniors updates by email What's this? GO Related Health Topics Nutrition Seniors' Health National Institutes of Health The ...

Blood Count Tests: MedlinePlus Health Topic

Science.gov (United States)

... Spanish WBC count (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Blood Count Tests ... WBC count Show More Show Less Related Health Topics Bleeding Disorders Blood Laboratory Tests National Institutes of ...

Hormone Replacement Therapy: MedlinePlus Health Topic

Science.gov (United States)

... of hormone therapy (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Hormone Replacement Therapy ... Estrogen overdose Types of hormone therapy Related Health Topics Menopause National Institutes of Health The primary NIH ...

Topics in millimeter wave technology

CERN Document Server

Button, Kenneth

1988-01-01

Topics in Millimeter Wave Technology, Volume 1 presents topics related to millimeter wave technology, including fin-lines and passive components realized in fin-lines, suspended striplines, suspended substrate microstrips, and modal power exchange in multimode fibers. A miniaturized monopulse assembly constructed in planar waveguide with multimode scalar horn feeds is also described. This volume is comprised of five chapters; the first of which deals with the analysis and synthesis techniques for fin-lines as well as the various passive components realized in fin-line. Tapers, discontinuities,

MANAGEMENT EFFECTS ON GROUND COVER CLUMPINESS: SCALING FROM FIELD TO SENTINEL-2 COVER ESTIMATES

Directory of Open Access Journals (Sweden)

P. Scarth

2017-11-01

Full Text Available Significant progress has been made in the development of cover data and derived products based on remotely sensed fractional cover information and field data across Australia, and these cover data sets are now used for quantifying and monitoring grazing land condition. The availability of a dense time-series of nearly 30 years of cover data to describe the spatial and temporal patterns in landscape changes over time can help with monitoring the effectiveness of grazing land management practice change. With the advent of higher spatial resolution data, such as that provided by the Copernicus Sentinel 2 series of satellites, we can look beyond reporting purely on cover amount and more closely at the operational monitoring and reporting on spatial arrangement of cover and its links with land condition. We collected high spatial resolution cover transects at 20 cm intervals over the Wambiana grazing trials in the Burdekin catchment in Queensland, Australia. Spatial variance analysis was used to determine the cover autocorrelation at various support intervals. Coincident Sentinel-2 imagery was collected and processed over all the sites providing imagery to link with the field data. We show that the spatial arrangement and temporal dynamics of cover are important indicators of grazing land condition for both productivity and water quality outcomes. The metrics and products derived from this research will assist land managers to prioritize investment and practice change strategies for long term sustainability and improved water quality, particularly in the Great Barrier Reef catchments.

Landfill covers for dry environments

International Nuclear Information System (INIS)

Dwyer, S.F.

1996-01-01

A large-scale landfill cover field test is currently underway at Sandia National Laboratories in Albuquerque, New Mexico. It is intended to compare and document the performance of alternative landfill cover technologies of various costs and complexities for interim stabilization and/or final closure of landfills in arid and semi-arid environments. Test plots of traditional designs recommended by the US Environmental Protection Agency for both RCRA Subtitle open-quote C close-quote and open-quote D close-quote regulated facilities have been constructed side-by-side with the alternative covers and will serve as baselines for comparison to these alternative covers. The alternative covers were designed specifically for dry environments. The covers will be tested under both ambient and stressed conditions. All covers have been instrumented to measure water balance variables and soil temperature. An on-site weather station records all pertinent climatological data. A key to acceptance of an alternative environmental technology is seeking regulatory acceptance and eventual permitting. The lack of acceptance by regulatory agencies is a significant barrier to development and implementation of innovative cover technologies. Much of the effort on this demonstration has been toward gaining regulatory and public acceptance

On approximating restricted cycle covers

NARCIS (Netherlands)

Manthey, Bodo

2008-01-01

A cycle cover of a graph is a set of cycles such that every vertex is part of exactly one cycle. An $L$-cycle cover is a cycle cover in which the length of every cycle is in the set $L$. The weight of a cycle cover of an edge-weighted graph is the sum of the weights of its edges. We come close to

Topical report review status. Volume 7, No. 2

International Nuclear Information System (INIS)

1984-11-01

Purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the NRC staff review has been completed and those which are under review and to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions are deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility

Development and Evaluation of Topical Gabapentin Formulations

Science.gov (United States)

Alcock, Natalie; Hiom, Sarah; Birchall, James C.

2017-01-01

Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hydrogels containing various permeation enhancers, and a range of proprietary bases including a compounded Lipoderm® formulation; furthermore microneedle facilitated delivery was used as a positive control. Critically, permeation of gabapentin across a human epidermal membrane in vitro was assessed using Franz-type diffusion cells. Subsequently this data was contextualised within the wider scope of the literature. Although reports of topical gabapentin delivery have been shown to vary, largely dependent upon the skin model used, this study demonstrated that 6% (w/w) gabapentin 0.75% (w/w) Carbopol® hydrogels containing 5% (w/w) DMSO or 70% (w/w) ethanol and a compounded 10% (w/w) gabapentin Lipoderm® formulation were able to facilitate permeation of the molecule across human skin. Further pre-clinical and clinical studies are required to investigate the topical delivery performance and pharmacodynamic actions of prospective formulations. PMID:28867811

Selected topics in nuclear structure

Energy Technology Data Exchange (ETDEWEB)

Solov` ev, V G; Gromov, K Ya; Malov, L A; Shilov, V M

1994-12-31

The Fourth International Conference on selected topics in nuclear structure was held at Dubna in July 1994 on recent experimental and theoretical investigations in nuclear structure. Topics discussed were the following: nuclear structure at low-energy excitations (collective quasiparticle phenomena, proton-neutron interactions, microscopic and phenomenological theories of nuclear structure; nuclear structure studies with charged particles). heavy ions, neutrons and photons; nuclei at high angular momenta and superdeformation, structure and decay properties of giant resonances, charge-exchange resonances and {beta}-decay; semiclassical approach of large amplitude collective motion and structure of hot nuclei.

Selected topics in nuclear structure

International Nuclear Information System (INIS)

Solov'ev, V.G.; Gromov, K.Ya.; Malov, L.A.; Shilov, V.M.

1994-01-01

The Fourth International Conference on selected topics in nuclear structure was held at Dubna in July 1994 on recent experimental and theoretical investigations in nuclear structure. Topics discussed were the following: nuclear structure at low-energy excitations (collective quasiparticle phenomena, proton-neutron interactions, microscopic and phenomenological theories of nuclear structure; nuclear structure studies with charged particles. heavy ions, neutrons and photons; nuclei at high angular momenta and superdeformation, structure and decay properties of giant resonances, charge-exchange resonances and β-decay; semiclassical approach of large amplitude collective motion and structure of hot nuclei

Handout on Health: Back Pain

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... Manipulation . Professionals use their hands to adjust or massage the spine or nearby tissues. Transcutaneous electrical nerve ... to the bones in the spine or by osteoporosis. Degenerative disk disease , or damage to the spine’s ...

Topical Antibacterials and Global Challenges on Resistance ...

African Journals Online (AJOL)

skin infections can be easily treated with topical antibacterial medication that is available over the counter or by ... infection in minor cut or burn, eyes and ear infection [5]. .... Sensitive/dry skin ... includes both oral and topical antibiotics, but.

Topical phenytoin for treating pressure ulcers.

Science.gov (United States)

Hao, Xiang Yong; Li, Hong Ling; Su, He; Cai, Hui; Guo, Tian Kang; Liu, Ruifeng; Jiang, Lei; Shen, Yan Fei

2017-02-22

Pressure ulcers are common in clinical practice and pose a significant health problem worldwide. Apart from causing suffering to patients, they also result in longer hospital stays and increase the cost of health care. A variety of methods are used for treating pressure ulcers, including pressure relief, patient repositioning, biophysical strategies, nutritional supplementation, debridement, topical negative pressure, and local treatments including dressings, ointments and creams such as bacitracin, silver sulphadiazine, neomycin, and phenytoin. Phenytoin is a drug more commonly used in the treatment of epilepsy, but may play an important role in accelerating ulcer healing. To assess the effects of topical phenytoin on the rate of healing of pressure ulcers of any grade, in any care setting. In September 2016, we searched the following electronic databases to identify relevant randomized clinical trials: the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL; the Cochrane Library); Ovid MEDLINE; Ovid Embase; and EBSCO CINAHL Plus. We handsearched conference proceedings from the European Pressure Ulcer Advisory Panel, European Wound Management Association and the Tissue Viability Society for all available years. We searched the references of the retrieved trials to identify further relevant trials. We also searched clinical trials registries to identify ongoing and unpublished studies. There were no restrictions with respect to language, date of publication or study setting. We included all randomized controlled trials (RCTs) addressing the effects (both benefits and harms) of topical phenytoin on the healing of pressure ulcers of any grade compared with placebo or alternative treatments or no therapy, irrespective of blinding, language, and publication status. Two review authors independently selected studies, extracted information on participants, interventions, methods and results and assessed risk of bias using

Videos, Podcasts and Livechats

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Full Text Available ... About Donate Search Search What Is It Definition Pediatric Palliative Care Disease Types FAQ Handout for Patients ... diagnosis or treatment. What Is Palliative Care Definition Pediatric Palliative Care Disease Types FAQ Handout for Patients ...

Videos, Podcasts and Livechats

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Full Text Available ... Pediatric Palliative Care Disease Types FAQ Handout for Patients and Families Is It Right for You How ... cancer story Access the Provider Directory Handout for Patients and Families Is it Right for You? Podcasts ...

Topics in Finance Part VII--Dividend Policy

Science.gov (United States)

Laux, Judy

2011-01-01

This series inspects the major topics in finance, reviewing the roles of stockholder wealth maximization, the risk-return tradeoff, and agency conflicts. The current article, devoted to dividend policy, also reviews the topic as presented in textbooks and the literature.

Topics in Nuclear Astrophysics

International Nuclear Information System (INIS)

Chung, K.C.

1982-01-01

Some topics in nuclear astrophysics are discussed, e.g.: highly evolved stellar cores, stellar evolution (through the temperature analysis of stellar surface), nucleosynthesis and finally the solar neutrino problem. (L.C.) [pt

Diabetes HealthSense: Resources for Living Well

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Full Text Available ... diabetes and preventing kidney disease. Player Controls Use these controls to control the play back of videos. ... Emotions AADE7 Self-Care Behaviors Handouts - Healthy Coping These handouts provide facts, tips, advice, and activities for ...

Diabetes HealthSense: Resources for Living Well

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Full Text Available ... Cope with Stress and Emotions AADE7 Self-Care Behaviors Handouts - Healthy Coping These handouts provide facts, tips, ... onset of the disease. MOVE! This national weight management program is designed to help veterans lose weight, ...

Videos, Podcasts and Livechats

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Full Text Available ... FAQ Handout for Patients and Families Is It Right for You How to Get It Talk to ... Directory Handout for Patients and Families Is it Right for You? Podcasts Copyright © 2018, Center to Advance ...

Diabetes HealthSense: Resources for Living Well

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Full Text Available ... right track. Cope with Stress and Emotions AADE7 Self-Care Behaviors Handouts - Healthy Coping These handouts provide ... advice, and activities for seven different areas of self-care to focus on when you are trying ...

Diabetes HealthSense: Resources for Living Well

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Full Text Available ... track. Cope with Stress and Emotions AADE7 Self-Care Behaviors Handouts - Healthy Coping These handouts provide facts, ... and activities for seven different areas of self-care to focus on when you are trying to ...

Diabetes HealthSense: Resources for Living Well

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Full Text Available ... Diabetes and Kidney Disease 12 Diabetes is the leading cause of kidney disease. People living with diabetes ... right track. Cope with Stress and Emotions AADE7 Self-Care Behaviors Handouts - Healthy Coping These handouts provide ...

Diabetes HealthSense: Resources for Living Well

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Full Text Available ... tips on managing your diabetes and preventing kidney disease. Player Controls Use these controls to control the play ... with Stress and Emotions AADE7 Self-Care Behaviors Handouts - Healthy Coping These handouts provide facts, tips, ...

Case Of Iatrogenic Cushing's Syndrome By Topical Triamcinolone.

Science.gov (United States)

Zil-E-Ali, Ahsan; Janjua, Omer Hanif; Latif, Aiza; Aadil, Muhammad

2018-01-01

Cushing's syndrome is a collection of signs and symptoms due to hypercortisolism. Prolong use of topical steroid may cause this syndrome and suppression of hypothalamic and pituitary function, however such events are more common with oral and parenteral route. There are very few cases of Cushing's syndrome with a topical application amongst which triamcinolone is the rarest drug. We report a case of 11-year-old boy is presented who developed Cushing's disease by topical application. The child had body rashes for which the caregiver consulted a local quack, a topical cream of triamcinolone was prescribed. After application for three months, the patient became obese and developed a moon-like face. A thorough biochemical workup and diagnostic test for Cushing's disease was done to confirm. The following case report a dramatic example of development of the syndrome from chronic topical application of the least potent corticosteroid.

Interpretable Topic Features for Post-ICU Mortality Prediction.

Science.gov (United States)

Luo, Yen-Fu; Rumshisky, Anna

2016-01-01

Electronic health records provide valuable resources for understanding the correlation between various diseases and mortality. The analysis of post-discharge mortality is critical for healthcare professionals to follow up potential causes of death after a patient is discharged from the hospital and give prompt treatment. Moreover, it may reduce the cost derived from readmissions and improve the quality of healthcare. Our work focused on post-discharge ICU mortality prediction. In addition to features derived from physiological measurements, we incorporated ICD-9-CM hierarchy into Bayesian topic model learning and extracted topic features from medical notes. We achieved highest AUCs of 0.835 and 0.829 for 30-day and 6-month post-discharge mortality prediction using baseline and topic proportions derived from Labeled-LDA. Moreover, our work emphasized the interpretability of topic features derived from topic model which may facilitates the understanding and investigation of the complexity between mortality and diseases.

Exploring Topic Structure: Coherence, Diversity and Relatedness

NARCIS (Netherlands)

J. He (Jiyin)

2011-01-01

htmlabstractThe use of topical information has long been studied in the context of information retrieval. For example, grouping search results into topical categories enables more effective information presentation to users, while grouping documents in a collection can lead to efficient information

topicmodels: An R Package for Fitting Topic Models

Directory of Open Access Journals (Sweden)

Bettina Grun

2011-05-01

Full Text Available Topic models allow the probabilistic modeling of term frequency occurrences in documents. The fitted model can be used to estimate the similarity between documents as well as between a set of specified keywords using an additional layer of latent variables which are referred to as topics. The R package topicmodels provides basic infrastructure for fitting topic models based on data structures from the text mining package tm. The package includes interfaces to two algorithms for fitting topic models: the variational expectation-maximization algorithm provided by David M. Blei and co-authors and an algorithm using Gibbs sampling by Xuan-Hieu Phan and co-authors.

Topical Research: Africa.

Science.gov (United States)

Lynn, Karen

This lesson plan can be used in social studies, language arts, or library research. The instructional objective is for students to select a topic of study relating to Africa, write a thesis statement, collect information from media sources, and develop a conclusion. The teacher may assign the lesson for written or oral evaluation. The teacher…

Topic structure affects semantic integration: evidence from event-related potentials.

Science.gov (United States)

Yang, Xiaohong; Chen, Xuhai; Chen, Shuang; Xu, Xiaoying; Yang, Yufang

2013-01-01

This study investigated whether semantic integration in discourse context could be influenced by topic structure using event-related brain potentials. Participants read discourses in which the last sentence contained a critical word that was either congruent or incongruent with the topic established in the first sentence. The intervening sentences between the first and the last sentence of the discourse either maintained or shifted the original topic. Results showed that incongruent words in topic-maintained discourses elicited an N400 effect that was broadly distributed over the scalp while those in topic-shifted discourses elicited an N400 effect that was lateralized to the right hemisphere and localized over central and posterior areas. Moreover, a late positivity effect was only elicited by incongruent words in topic-shifted discourses, but not in topic-maintained discourses. This suggests an important role for discourse structure in semantic integration, such that compared with topic-maintained discourses, the complexity of discourse structure in topic-shifted condition reduces the initial stage of semantic integration and enhances the later stage in which a mental representation is updated.

Diclofenac Topical (osteoarthritis pain)

Science.gov (United States)

... gel (Voltaren) is used to relieve pain from osteoarthritis (arthritis caused by a breakdown of the lining ... Diclofenac topical liquid (Pennsaid) is used to relieve osteoarthritis pain in the knees. Diclofenac is in a ...

Diclofenac Topical (actinic keratosis)

Science.gov (United States)

... topical gel (Solaraze) is used to treat actinic keratosis (flat, scaly growths on the skin caused by ... The way diclofenac gel works to treat actinic keratosis is not known.Diclofenac is also available as ...

Diabetes HealthSense: Resources for Living Well

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Full Text Available ... Cope with Stress and Emotions AADE7 Self-Care Behaviors Handouts - Healthy Coping These handouts provide facts, tips, ... professional K-8th grade Community health worker Community organization Age Select one: Child Teen and young adult ...

Diabetes HealthSense: Resources for Living Well

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Full Text Available ... the text smaller. U.S. Department of Health and Human Services HOME | CONTACT US | JOBS AT NIDDK | RSS ... Cope with Stress and Emotions AADE7 Self-Care Behaviors Handouts - Healthy Coping These handouts provide facts, tips, ...

Digital Social Network Mining for Topic Discovery

Science.gov (United States)

Moradianzadeh, Pooya; Mohi, Maryam; Sadighi Moshkenani, Mohsen

Networked computers are expanding more and more around the world, and digital social networks becoming of great importance for many people's work and leisure. This paper mainly focused on discovering the topic of exchanging information in digital social network. In brief, our method is to use a hierarchical dictionary of related topics and words that mapped to a graph. Then, with comparing the extracted keywords from the context of social network with graph nodes, probability of relation between context and desired topics will be computed. This model can be used in many applications such as advertising, viral marketing and high-risk group detection.

ANS [American Nuclear Society] topical meeting on radiological accidents: Perspectives and emergency planning: Proceedings

International Nuclear Information System (INIS)

1987-03-01

The increasing use of radioactive materials and the increasing public concern about possible accidents involving these materials has led to greater emphasis on preparing for such emergencies. The ANS Topical Meeting on Radiological Accidents - Perspectives and Emergency Planning provided a review of experiences with radiological accidents. The meeting covered some of the most important aspects of radiological accidents. Papers were presented which dealt with radiological accident experience. Technical response to accidents is of primary interest to many in the nuclear community; most of the papers submitted fell into this area. So many of these papers dealt with the use of computers in response that a session on that topic was arranged. A very significant impact of most radiological accidents is the cost, especially the cost of cleanup. There were papers on what is known about costs and associated current topics, such as modification and extension of the Price-Anderson Act. At least as important as the technical response to accidents is how society attempts to deal with them. A session on institutional issues was included to discuss how governments and other organizations respond to and deal with accidents. Medical effects of accidents are of great concern to the public. Invited papers to review the effects of high doses of radiation as well as very low doses were included in that session. Although the nuclear industry has an excellent safety record, this fact often does not agree with the public perception of the industry. The final session explored the public response to and perception of radiological emergencies and accidents. This subject will ultimately determine the future use of radioactive materials in this country

Development and Evaluation of Topical Gabapentin Formulations

Directory of Open Access Journals (Sweden)

Christopher J. Martin

2017-08-01

Full Text Available Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hydrogels containing various permeation enhancers, and a range of proprietary bases including a compounded Lipoderm® formulation; furthermore microneedle facilitated delivery was used as a positive control. Critically, permeation of gabapentin across a human epidermal membrane in vitro was assessed using Franz-type diffusion cells. Subsequently this data was contextualised within the wider scope of the literature. Although reports of topical gabapentin delivery have been shown to vary, largely dependent upon the skin model used, this study demonstrated that 6% (w/w gabapentin 0.75% (w/w Carbopol® hydrogels containing 5% (w/w DMSO or 70% (w/w ethanol and a compounded 10% (w/w gabapentin Lipoderm® formulation were able to facilitate permeation of the molecule across human skin. Further pre-clinical and clinical studies are required to investigate the topical delivery performance and pharmacodynamic actions of prospective formulations.

Completion of the National Land Cover Database (NLCD) 1992-2001 Land Cover Change Retrofit Product

Science.gov (United States)

The Multi-Resolution Land Characteristics Consortium has supported the development of two national digital land cover products: the National Land Cover Dataset (NLCD) 1992 and National Land Cover Database (NLCD) 2001. Substantial differences in imagery, legends, and methods betwe...

Climate Impacts of Cover Crops

Science.gov (United States)

Lombardozzi, D.; Wieder, W. R.; Bonan, G. B.; Morris, C. K.; Grandy, S.

2016-12-01

Cover crops are planted in agricultural rotation with the intention of protecting soil rather than harvest. Cover crops have numerous environmental benefits that include preventing soil erosion, increasing soil fertility, and providing weed and pest control- among others. In addition to localized environmental benefits, cover crops can have important regional or global biogeochemical impacts by increasing soil organic carbon, changing emissions of greenhouse trace gases like nitrous oxide and methane, and reducing hydrologic nitrogen losses. Cover crops may additionally affect climate by changing biogeophysical processes, like albedo and latent heat flux, though these potential changes have not yet been evaluated. Here we use the coupled Community Atmosphere Model (CAM5) - Community Land Model (CLM4.5) to test how planting cover crops in the United States may change biogeophysical fluxes and climate. We present seasonal changes in albedo, heat fluxes, evaporative partitioning, radiation, and the resulting changes in temperature. Preliminary analyses show that during seasons when cover crops are planted, latent heat flux increases and albedo decreases, changing the evaporative fraction and surface temperatures. Understanding both the biogeophysical changes caused by planting cover crops in this study and the biogeochemical changes found in other studies will give a clearer picture of the overall impacts of cover crops on climate and atmospheric chemistry, informing how this land use strategy will impact climate in the future.

Influence of input matrix representation on topic modelling performance

CSIR Research Space (South Africa)

De Waal, A

2010-11-01

Full Text Available Topic models explain a collection of documents with a small set of distributions over terms. These distributions over terms define the topics. Topic models ignore the structure of documents and use a bag-of-words approach which relies solely...

Proceedings of the self-healing topical session of the IGSC Working Group on Measurement and Physical Understanding of Groundwater Flow through Argillaceous Media (Clay Club)

International Nuclear Information System (INIS)

2001-01-01

A Topical Session focused on the 'Evidence of, and Approaches to Self-Healing in Argillaceous Media' was organised in the framework to the 11. meeting of the Clay Club. It was held at Nancy in France on 16 May 2001 at the invitation of the French Organisation for Radioactive Waste Management (ANDRA). Twenty-six participants representing several national waste management organisations, regulatory authorities, geological surveys as well as academic community took part in the session. The Topical session was mainly aimed at exchanging information on: - The general point of view on self-healing from geomechanical and geochemical experts; - The approaches that are or will be followed by the various organisations in order to deal with self-healing. The geological settings covered in the presentations concerned the whole range of argillaceous media, from soft, plastic clays to indurated clay-stones, currently studied with respect to deep disposal of radioactive waste. The Topical Session showed the importance of a multidisciplinary approach to this topic. The presentations emphasised the interest of a state-of-the-art report on self-healing to provide a sound and disposal-dedicated scientific framework for subsequent studies related to this area

Topical methotrexate pretreatment enhances the therapeutic effect of topical 5-aminolevulinic acid-mediated photodynamic therapy on hamster buccal pouch precancers

Directory of Open Access Journals (Sweden)

Deng-Fu Yang

2014-09-01

Conclusion: We conclude that topical MTX-pretreatment can increase intracellular PpIX production in hamster buccal pouch precancerous lesions and significantly improves the outcomes of the precancerous lesions treated with topical ALA-PDT.

Diabetes HealthSense: Resources for Living Well

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Full Text Available ... right track. Cope with Stress and Emotions AADE7 Self-Care Behaviors Handouts - Healthy Coping These handouts provide facts, ... advice, and activities for seven different areas of self-care to focus on when you are trying to ...

A Data-Based Approach to Discovering Multi-Topic Influential Leaders.

Directory of Open Access Journals (Sweden)

Xing Tang

Full Text Available Recently, increasing numbers of users have adopted microblogging services as their main information source. However, most of them find themselves drowning in the millions of posts produced by other users every day. To cope with this, identifying a set of the most influential people is paramount. Moreover, finding a set of related influential users to expand the coverage of one particular topic is required in real world scenarios. Most of the existing algorithms in this area focus on topology-related methods such as PageRank. These methods mine link structures to find the expected influential rank of users. However, because they ignore the interaction data, these methods turn out to be less effective in social networks. In reality, a variety of topics exist within the information diffusing through the network. Because they have different interests, users play different roles in the diffusion of information related to different topics. As a result, distinguishing influential leaders according to different topics is also worthy of research. In this paper, we propose a multi-topic influence diffusion model (MTID based on traces acquired from historic information. We decompose the influential scores of users into two parts: the direct influence determined by information propagation along the link structure and indirect influence that extends beyond the restrictions of direct follower relationships. To model the network from a multi-topical viewpoint, we introduce topic pools, each of which represents a particular topic information source. Then, we extract the topic distributions from the traces of tweets, determining the influence propagation probability and content generation probability. In the network, we adopt multiple ground nodes representing topic pools to connect every user through bidirectional links. Based on this multi-topical view of the network, we further introduce the topic-dependent rank (TD-Rank algorithm to identify the multi-topic

A Data-Based Approach to Discovering Multi-Topic Influential Leaders.

Science.gov (United States)

Tang, Xing; Miao, Qiguang; Yu, Shangshang; Quan, Yining

2016-01-01

Recently, increasing numbers of users have adopted microblogging services as their main information source. However, most of them find themselves drowning in the millions of posts produced by other users every day. To cope with this, identifying a set of the most influential people is paramount. Moreover, finding a set of related influential users to expand the coverage of one particular topic is required in real world scenarios. Most of the existing algorithms in this area focus on topology-related methods such as PageRank. These methods mine link structures to find the expected influential rank of users. However, because they ignore the interaction data, these methods turn out to be less effective in social networks. In reality, a variety of topics exist within the information diffusing through the network. Because they have different interests, users play different roles in the diffusion of information related to different topics. As a result, distinguishing influential leaders according to different topics is also worthy of research. In this paper, we propose a multi-topic influence diffusion model (MTID) based on traces acquired from historic information. We decompose the influential scores of users into two parts: the direct influence determined by information propagation along the link structure and indirect influence that extends beyond the restrictions of direct follower relationships. To model the network from a multi-topical viewpoint, we introduce topic pools, each of which represents a particular topic information source. Then, we extract the topic distributions from the traces of tweets, determining the influence propagation probability and content generation probability. In the network, we adopt multiple ground nodes representing topic pools to connect every user through bidirectional links. Based on this multi-topical view of the network, we further introduce the topic-dependent rank (TD-Rank) algorithm to identify the multi-topic influential users

Topical melatonin for treatment of androgenetic alopecia.

Science.gov (United States)

Fischer, Tobias W; Trüeb, Ralph M; Hänggi, Gabriella; Innocenti, Marcello; Elsner, Peter

2012-10-01

In the search for alternative agents to oral finasteride and topical minoxidil for the treatment of androgenetic alopecia (AGA), melatonin, a potent antioxidant and growth modulator, was identified as a promising candidate based on in vitro and in vivo studies. One pharmacodynamic study on topical application of melatonin and four clinical pre-post studies were performed in patients with androgenetic alopecia or general hair loss and evaluated by standardised questionnaires, TrichoScan, 60-second hair count test and hair pull test. FIVE CLINICAL STUDIES SHOWED POSITIVE EFFECTS OF A TOPICAL MELATONIN SOLUTION IN THE TREATMENT OF AGA IN MEN AND WOMEN WHILE SHOWING GOOD TOLERABILITY: (1) Pharmacodynamics under once-daily topical application in the evening showed no significant influence on endogenous serum melatonin levels. (2) An observational study involving 30 men and women showed a significant reduction in the degree of severity of alopecia after 30 and 90 days (P melatonin solution can be considered as a treatment option in androgenetic alopecia.

Interactional Organization and Topic Control in Conciliation Hearings

Directory of Open Access Journals (Sweden)

Wânia Terezinha Ladeira

2011-07-01

Full Text Available We analyse discursive topic in talk-in-interaction within the institutional setting of three conciliation hearings held in a kind of small claims court for consumption conflict resolution. This research is based on Interactional Sociolinguistics and Conversation Analysis theories. The analysis shows that the participants of those meetings have asymmetric rights regarding the choice of discussion topics. Thus, the mediator is the one who has the right to suggest and control the discursive topics of the conversation. This topic control is the most important institutional procedure that can cause a reduction in accusations and adjacent replies. Consequently, the chance of mediators achieving their institutional task of reaching an agreement between parts in conflict is increased.

Evaluation of the LMFBR cover gas source term and synthesis of the associated R and D

International Nuclear Information System (INIS)

Balard, F.; Carluec, B.

1996-01-01

At the end of the seventies and the beginning of the eighties, there appeared a pressing need of experimental results to assess the LMFBR's safety level. Because of the urgency, analytical studies were not systematically undertaken and maximum credible cover gas instantaneous source terms (radionuclides core release fraction) were got directly from crude out-of-pile experiment interpretations. Two types of studies and mock-ups were undertaken depending on the timescale of the phenomena: instantaneous source terms (corresponding to an unlikely energetic core disruptive accident CDA), and delayed ones (tens of minutes to some hours). The experiments performed in this frame are reviewed in this presentation: 1) instantaneous source term: - FAUST experiments: I, Cs, UO2 source terms (FzK, Germany), - FAST experiments : pool depth influence on non volatile source term (USA), - CARAVELLE experiments: nonvolatile source term in SPX1 geometry (CEA, France); 2) delayed source term: - NALA experiments: I, Cs, Sr, UO2 source term (FzK, Germany), - PAVE experiments: I source term (CEA, France), - NACOWA experiments: cover gas aerosols enrichment in I and Cs (FzK, Germany) - other French experiments in COPACABANA and GULLIVER facilities. The volatile fission products release is tightly bound to sodium evaporation and a large part of the fission products is dissolved in the liquid sodium aerosols present in the cover gas. Thus the knowledge of the amount of aerosol release to the cover gas is important for the evaluation of the source term. The maximum credible cover gas instantaneous source terms deduced from the experiments have led to conservative source terms to be taken into account in safety analysis. Nevertheless modelling attempts of the observed (in-pile or out-of-pile) physico-chemical phenomena have been undertaken for extrapolation to the reactor case. The main topics of this theoretical research are as follows: fission products evaporation in the cover gas (Fz

The use of compound topical anesthetics: a review.

Science.gov (United States)

Kravitz, Neal D

2007-10-01

The author reviewed the history of, federal regulations regarding, risks of and adverse drug reactions of five compound topical anesthetics: tetracaine, adrenaline/epinephrine and cocaine (TAC); lidocaine, adrenaline/epinephrine and tetracaine (LET); lidocaine, tetracaine and phenylephrine (TAC 20 percent Alternate); lidocaine, prilocaine and tetracaine (Profound); and lidocaine, prilocaine, tetracaine and phenylephrine with thickeners (Profound PET). The author reviewed clinical trials, case reports, descriptive articles, and U.S. Food and Drug Administration (FDA) regulations and recent public advisory warnings regarding the federal approval of and risks associated with the use of compound topical anesthetics. Compound topical anesthetics are neither FDA-regulated nor -unregulated. Some compounding pharmacies bypass the new FDA drug approval process, which is based on reliable scientific data and ensures that a marketed drug is safe, effective, properly manufactured and accurately labeled. Two deaths have been attributed to the lay use of compound topical anesthetics. In response, the FDA has announced the strengthening of its efforts against unapproved drug products. Compound topical anesthetics may be an effective alternative to local infiltration for some minimally invasive dental procedures; however, legitimate concerns exist in regard to their safety. Until they become federally regulated, compound topical anesthetics remain unapproved drug products whose benefits may not outweigh their risks for dental patients.

Topical Apigenin Alleviates Cutaneous Inflammation in Murine Models

Directory of Open Access Journals (Sweden)

Mao-Qiang Man

2012-01-01

Full Text Available Herbal medicines have been used in preventing and treating skin disorders for centuries. It has been demonstrated that systemic administration of chrysanthemum extract exhibits anti-inflammatory properties. However, whether topical applications of apigenin, a constituent of chrysanthemum extract, influence cutaneous inflammation is still unclear. In the present study, we first tested whether topical applications of apigenin alleviate cutaneous inflammation in murine models of acute dermatitis. The murine models of acute allergic contact dermatitis and acute irritant contact dermatitis were established by topical application of oxazolone and phorbol 12-myristate 13-acetate (TPA, respectively. Inflammation was assessed in both dermatitis models by measuring ear thickness. Additionally, the effect of apigenin on stratum corneum function in a murine subacute allergic contact dermatitis model was assessed with an MPA5 physiology monitor. Our results demonstrate that topical applications of apigenin exhibit therapeutic effects in both acute irritant contact dermatitis and allergic contact dermatitis models. Moreover, in comparison with the vehicle treatment, topical apigenin treatment significantly reduced transepidermal water loss, lowered skin surface pH, and increased stratum corneum hydration in a subacute murine allergic contact dermatitis model. Together, these results suggest that topical application of apigenin could provide an alternative regimen for the treatment of dermatitis.

Knowledge-Based Topic Model for Unsupervised Object Discovery and Localization.

Science.gov (United States)

Niu, Zhenxing; Hua, Gang; Wang, Le; Gao, Xinbo

Unsupervised object discovery and localization is to discover some dominant object classes and localize all of object instances from a given image collection without any supervision. Previous work has attempted to tackle this problem with vanilla topic models, such as latent Dirichlet allocation (LDA). However, in those methods no prior knowledge for the given image collection is exploited to facilitate object discovery. On the other hand, the topic models used in those methods suffer from the topic coherence issue-some inferred topics do not have clear meaning, which limits the final performance of object discovery. In this paper, prior knowledge in terms of the so-called must-links are exploited from Web images on the Internet. Furthermore, a novel knowledge-based topic model, called LDA with mixture of Dirichlet trees, is proposed to incorporate the must-links into topic modeling for object discovery. In particular, to better deal with the polysemy phenomenon of visual words, the must-link is re-defined as that one must-link only constrains one or some topic(s) instead of all topics, which leads to significantly improved topic coherence. Moreover, the must-links are built and grouped with respect to specific object classes, thus the must-links in our approach are semantic-specific , which allows to more efficiently exploit discriminative prior knowledge from Web images. Extensive experiments validated the efficiency of our proposed approach on several data sets. It is shown that our method significantly improves topic coherence and outperforms the unsupervised methods for object discovery and localization. In addition, compared with discriminative methods, the naturally existing object classes in the given image collection can be subtly discovered, which makes our approach well suited for realistic applications of unsupervised object discovery.Unsupervised object discovery and localization is to discover some dominant object classes and localize all of object

Topic Prominence in Chinese EFL Learners' Interlanguage

Science.gov (United States)

Li, Shaopeng; Yang, Lianrui

2014-01-01

The present study aims to investigate the general characteristics of topicprominent typological interlanguage development of Chinese learners of English in terms of acquiring subject-prominent English structures from a discourse perspective. Topic structures mainly appear in Chinese discourse in the form of topic chains (Wang, 2002; 2004). The…

Completion of the National Land Cover Database (NLCD) 1992–2001 Land Cover Change Retrofit product

Science.gov (United States)

Fry, J.A.; Coan, Michael; Homer, Collin G.; Meyer, Debra K.; Wickham, J.D.

2009-01-01

The Multi-Resolution Land Characteristics Consortium has supported the development of two national digital land cover products: the National Land Cover Dataset (NLCD) 1992 and National Land Cover Database (NLCD) 2001. Substantial differences in imagery, legends, and methods between these two land cover products must be overcome in order to support direct comparison. The NLCD 1992-2001 Land Cover Change Retrofit product was developed to provide more accurate and useful land cover change data than would be possible by direct comparison of NLCD 1992 and NLCD 2001. For the change analysis method to be both national in scale and timely, implementation required production across many Landsat Thematic Mapper (TM) and Enhanced Thematic Mapper Plus (ETM+) path/rows simultaneously. To meet these requirements, a hybrid change analysis process was developed to incorporate both post-classification comparison and specialized ratio differencing change analysis techniques. At a resolution of 30 meters, the completed NLCD 1992-2001 Land Cover Change Retrofit product contains unchanged pixels from the NLCD 2001 land cover dataset that have been cross-walked to a modified Anderson Level I class code, and changed pixels labeled with a 'from-to' class code. Analysis of the results for the conterminous United States indicated that about 3 percent of the land cover dataset changed between 1992 and 2001.

A Discourse Perspective of Topic-prominence in Chinese EFL Learners’ Interlanguage

Directory of Open Access Journals (Sweden)

Shaopeng Li

2014-07-01

Full Text Available The present study aims to investigate the general characteristics of topic-prominent typological interlanguage development of Chinese learners of English in terms of acquiring subject-prominent English structures from the discourse perspective. We have selected as the research target “topic chain” which is the main topic-prominent structure in Chinese discourse and “zero anaphora” which is the most common topic anaphor of topic chain. Topic structures mainly appear in Chinese discourse in the form of “topic chain” (Wang, 2002; 2004. Actually, in the event of a topic chain, research on topic structures should go into the typical range of discourse. Two important findings were yielded by the present study. First, the characteristics of Chinese topic chain are transferrable to the interlanguage of Chinese EFL learners, thus resulting in overgeneralization of zero anaphora; second, interlanguage discourse of Chinese EFL learners reflects the characteristics of a second language acquisition process from topic-prominence to subject-prominence, thus lending support to the discourse transfer hypothesis.

Topical reports on Louisiana salt domes

International Nuclear Information System (INIS)

1983-09-01

The Institute for Environmental Studies at Louisiana State University conducted research into the potential use of Louisiana salt domes for disposal of nuclear waste material. Topical reports generated in 1981 and 1982 related to Vacherie and Rayburn's domes are compiled and presented, which address palynological studies, tiltmeter monitoring, precise releveling, saline springs, and surface hydrology. The latter two are basically a compilation of references related to these topics. Individual reports are abstracted

Data Mining Thesis Topics in Finland

OpenAIRE

Bajo Rouvinen, Ari

2017-01-01

The Theseus open repository contains metadata about more than 100,000 thesis publications from the different universities of applied sciences in Finland. Different data mining techniques were applied to the Theseus dataset to build a web application to explore thesis topics and degree programmes using different libraries in Python and JavaScript. Thesis topics were extracted from manually annotated keywords by the authors and curated subjects by the librarians. During the project, the quality...

Selected topics in e+e- physics

International Nuclear Information System (INIS)

Sau Lan Wu

1981-01-01

Selected topics of recent experimental results from the high-energy electron-positron storage rings are presented. The topics include some of the tau and charm physics from SPEAR, the upsilon physics from DORIS and CESR, and the γγ physics and quark and gluon physics from the PLUTO and TASSO Collaborations at PETRA. Related data from the JADE and MARK J Collaborations at PETRA are discussed in separated papers at this school. (orig.)

An overview of topic modeling and its current applications in bioinformatics.

Science.gov (United States)

Liu, Lin; Tang, Lin; Dong, Wen; Yao, Shaowen; Zhou, Wei

2016-01-01

With the rapid accumulation of biological datasets, machine learning methods designed to automate data analysis are urgently needed. In recent years, so-called topic models that originated from the field of natural language processing have been receiving much attention in bioinformatics because of their interpretability. Our aim was to review the application and development of topic models for bioinformatics. This paper starts with the description of a topic model, with a focus on the understanding of topic modeling. A general outline is provided on how to build an application in a topic model and how to develop a topic model. Meanwhile, the literature on application of topic models to biological data was searched and analyzed in depth. According to the types of models and the analogy between the concept of document-topic-word and a biological object (as well as the tasks of a topic model), we categorized the related studies and provided an outlook on the use of topic models for the development of bioinformatics applications. Topic modeling is a useful method (in contrast to the traditional means of data reduction in bioinformatics) and enhances researchers' ability to interpret biological information. Nevertheless, due to the lack of topic models optimized for specific biological data, the studies on topic modeling in biological data still have a long and challenging road ahead. We believe that topic models are a promising method for various applications in bioinformatics research.

Control of pain with topical plant medicines

Directory of Open Access Journals (Sweden)

James David Adams Jr.

2015-04-01

Full Text Available Pain is normally treated with oral nonsteroidal anti-inflammatory agents and opioids. These drugs are dangerous and are responsible for many hospitalizations and deaths. It is much safer to use topical preparations made from plants to treat pain, even severe pain. Topical preparations must contain compounds that penetrate the skin, inhibit pain receptors such as transient receptor potential cation channels and cyclooxygenase-2, to relieve pain. Inhibition of pain in the skin disrupts the pain cycle and avoids exposure of internal organs to large amounts of toxic compounds. Use of topical pain relievers has the potential to save many lives, decrease medical costs and improve therapy.

Topics in Finance Part VI--Capital Budgeting

Science.gov (United States)

Laux, Judy

2011-01-01

This series on the theory of financial management offers insight into the roles of stockholder wealth maximization, the risk-return tradeoff, and agency conflicts as they apply to major topics in finance. The current article investigates capital budgeting. Much literature addresses this topic, with a number of articles challenging mainstream…

Fostering Topic Knowledge: Essential for Academic Writing

Science.gov (United States)

Proske, Antje; Kapp, Felix

2013-01-01

Several researchers emphasize the role of the writer's topic knowledge for writing. In academic writing topic knowledge is often constructed by studying source texts. One possibility to support that essential phase of the writing process is to provide interactive learning questions which facilitate the construction of an adequate situation…

Diabetes HealthSense: Resources for Living Well

Medline Plus

Full Text Available ... the resources below to help you get on the right track. Cope with Stress and Emotions AADE7 Self-Care Behaviors Handouts - Healthy Coping These handouts provide ... This booklet addresses the special challenges for very large people who are ...

Ego Involvement and Topic Controversiality as Related to Attitude Change.

Science.gov (United States)

Sledden, Elizabeth A.; Fernandez, Katherine A.

Attitude change was measured on four different topics before and immediately after a persuasion was presented in order to compare the degree of change with the level of ego involvement as it relates to topic controversiality. Ego involvement was based on self-ratings of concern for each topic. Objective topic controversiality was based on the…

EvoRiver: Visual Analysis of Topic Coopetition on Social Media.

Science.gov (United States)

Sun, Guodao; Wu, Yingcai; Liu, Shixia; Peng, Tai-Quan; Zhu, Jonathan J H; Liang, Ronghua

2014-12-01

Cooperation and competition (jointly called "coopetition") are two modes of interactions among a set of concurrent topics on social media. How do topics cooperate or compete with each other to gain public attention? Which topics tend to cooperate or compete with one another? Who plays the key role in coopetition-related interactions? We answer these intricate questions by proposing a visual analytics system that facilitates the in-depth analysis of topic coopetition on social media. We model the complex interactions among topics as a combination of carry-over, coopetition recruitment, and coopetition distraction effects. This model provides a close functional approximation of the coopetition process by depicting how different groups of influential users (i.e., "topic leaders") affect coopetition. We also design EvoRiver, a time-based visualization, that allows users to explore coopetition-related interactions and to detect dynamically evolving patterns, as well as their major causes. We test our model and demonstrate the usefulness of our system based on two Twitter data sets (social topics data and business topics data).

Automatic design of magazine covers

Science.gov (United States)

Jahanian, Ali; Liu, Jerry; Tretter, Daniel R.; Lin, Qian; Damera-Venkata, Niranjan; O'Brien-Strain, Eamonn; Lee, Seungyon; Fan, Jian; Allebach, Jan P.

2012-03-01

In this paper, we propose a system for automatic design of magazine covers that quantifies a number of concepts from art and aesthetics. Our solution to automatic design of this type of media has been shaped by input from professional designers, magazine art directors and editorial boards, and journalists. Consequently, a number of principles in design and rules in designing magazine covers are delineated. Several techniques are derived and employed in order to quantify and implement these principles and rules in the format of a software framework. At this stage, our framework divides the task of design into three main modules: layout of magazine cover elements, choice of color for masthead and cover lines, and typography of cover lines. Feedback from professional designers on our designs suggests that our results are congruent with their intuition.

Report of the Federal Ministry for the Environment, Nature Conservation, Buildings and Nuclear Safety (BMUB) on the topical peer review aging management in nuclear power plants and research reactors

International Nuclear Information System (INIS)

2017-01-01

The report of the Federal Environmental Ministry (BMUB) on the topical peer review aging management in nuclear power plants and research reactors covers the following issues: comprehensive requirements for aging management and its implementation, electric cables, non accessible pipes, reactor pressure vessel, calandria/pressure tubes (CANDU), concrete containment, pre-stressed concrete reactor pressure vessel (AGR).

Selected topics in magnetism

CERN Document Server

Gupta, L C

1993-01-01

Part of the ""Frontiers in Solid State Sciences"" series, this volume presents essays on such topics as spin fluctuations in Heisenberg magnets, quenching of spin fluctuations by high magnetic fields, and kondo effect and heavy fermions in rare earths amongst others.

Topics in quantum theory

International Nuclear Information System (INIS)

Yuille, A.L.

1980-11-01

Topics in the Yang-Mills theories of strong interactions and the quantum theories of gravity are examined, using the path integral approach, including; Yang-Mills instantons in curved spacetimes, Israel-Wilson metrics, Kaehler spacetimes, instantons and anti-instantons. (U.K.)

Risk assessment of topically applied products

DEFF Research Database (Denmark)

Søborg, Tue; Basse, Line Hollesen; Halling-Sørensen, Bent

2007-01-01

The human risk of harmful substances in semisolid topical dosage forms applied topically to normal skin and broken skin, respectively, was assessed. Bisphenol A diglycidyl ether (BADGE) and three derivatives of BADGE previously quantified in aqueous cream and the UV filters 3-BC and 4-MBC were used...... as model compounds. Tolerable daily intake (TDI) values have been established for BADGE and derivatives. Endocrine disruption was chosen as endpoint for 3-BC and 4-MBC. Skin permeation of the model compounds was investigated in vitro using pig skin membranes. Tape stripping was applied to simulate broken...... parameters for estimating the risk. The immediate human risk of BADGE and derivatives in topical dosage forms was found to be low. However, local treatment of broken skin may lead to higher exposure of BADGE and derivatives compared to application to normal skin. 3-BC permeated skin at higher flux than 4-MBC...

Do cover crop mixtures have the same ability to suppress weeds as competitive monoculture cover crops?

Directory of Open Access Journals (Sweden)

Brust, Jochen

2014-02-01

Full Text Available An increasing number of farmers use cover crop mixtures instead of monoculture cover crops to improve soil and crop quality. However, only little information is available about the weed suppression ability of cover crop mixtures. Therefore, two field experiments were conducted in Baden-Württemberg between 2010 and 2012, to compare growth and weed suppression of monoculture cover crops and cover crop mixtures. In the first experiment, heterogeneous results between yellow mustard and the cover crop mixture occurred. For further research, a field experiment was conducted in 2012 to compare monocultures of yellow mustard and hemp with three cover crop mixtures. The evaluated mixtures were: “MELO”: for soil melioration; “BETA”: includes only plant species with no close relation to main cash crops in Central Europe and “GPS”: for usage as energy substrate in spring. Yellow mustard, MELO, BETA and GPS covered 90% of the soil in less than 42 days and were able to reduce photosynthetically active radiation (PAR on soil surface by more than 96% after 52 days. Hemp covered 90% of the soil after 47 days and reduced PAR by 91% after 52 days. Eight weeks after planting, only BETA showed similar growth to yellow mustard which produced the highest dry matter. The GPS mixture had comparatively poor growth, while MELO produced similar dry matter to hemp. Yellow mustard, MELO and BETA reduced weed growth by 96% compared with a no cover crop control, while hemp and GPS reduced weeds by 85% and 79%. In spring, weed dry matter was reduced by more than 94% in plots with yellow mustard and all mixtures, while in hemp plots weeds were only reduced by 71%. The results suggest that the tested cover crop mixtures offer similar weed suppression ability until spring as the monoculture of the competitive yellow mustard.

Detecting Hotspot Information Using Multi-Attribute Based Topic Model.

Directory of Open Access Journals (Sweden)

Jing Wang

Full Text Available Microblogging as a kind of social network has become more and more important in our daily lives. Enormous amounts of information are produced and shared on a daily basis. Detecting hot topics in the mountains of information can help people get to the essential information more quickly. However, due to short and sparse features, a large number of meaningless tweets and other characteristics of microblogs, traditional topic detection methods are often ineffective in detecting hot topics. In this paper, we propose a new topic model named multi-attribute latent dirichlet allocation (MA-LDA, in which the time and hashtag attributes of microblogs are incorporated into LDA model. By introducing time attribute, MA-LDA model can decide whether a word should appear in hot topics or not. Meanwhile, compared with the traditional LDA model, applying hashtag attribute in MA-LDA model gives the core words an artificially high ranking in results meaning the expressiveness of outcomes can be improved. Empirical evaluations on real data sets demonstrate that our method is able to detect hot topics more accurately and efficiently compared with several baselines. Our method provides strong evidence of the importance of the temporal factor in extracting hot topics.

Detecting Hotspot Information Using Multi-Attribute Based Topic Model

Science.gov (United States)

Wang, Jing; Li, Li; Tan, Feng; Zhu, Ying; Feng, Weisi

2015-01-01

Microblogging as a kind of social network has become more and more important in our daily lives. Enormous amounts of information are produced and shared on a daily basis. Detecting hot topics in the mountains of information can help people get to the essential information more quickly. However, due to short and sparse features, a large number of meaningless tweets and other characteristics of microblogs, traditional topic detection methods are often ineffective in detecting hot topics. In this paper, we propose a new topic model named multi-attribute latent dirichlet allocation (MA-LDA), in which the time and hashtag attributes of microblogs are incorporated into LDA model. By introducing time attribute, MA-LDA model can decide whether a word should appear in hot topics or not. Meanwhile, compared with the traditional LDA model, applying hashtag attribute in MA-LDA model gives the core words an artificially high ranking in results meaning the expressiveness of outcomes can be improved. Empirical evaluations on real data sets demonstrate that our method is able to detect hot topics more accurately and efficiently compared with several baselines. Our method provides strong evidence of the importance of the temporal factor in extracting hot topics. PMID:26496635

Gainesville's urban forest canopy cover

Science.gov (United States)

Francisco Escobedo; Jennifer A. Seitz; Wayne Zipperer

2009-01-01

Ecosystem benefits from trees are linked directly to the amount of healthy urban forest canopy cover. Urban forest cover is dynamic and changes over time due to factors such as urban development, windstorms, tree removals, and growth. The amount of a city's canopy cover depends on its land use, climate, and people's preferences. This fact sheet examines how...

Spectral Learning for Supervised Topic Models.

Science.gov (United States)

Ren, Yong; Wang, Yining; Zhu, Jun

2018-03-01

Supervised topic models simultaneously model the latent topic structure of large collections of documents and a response variable associated with each document. Existing inference methods are based on variational approximation or Monte Carlo sampling, which often suffers from the local minimum defect. Spectral methods have been applied to learn unsupervised topic models, such as latent Dirichlet allocation (LDA), with provable guarantees. This paper investigates the possibility of applying spectral methods to recover the parameters of supervised LDA (sLDA). We first present a two-stage spectral method, which recovers the parameters of LDA followed by a power update method to recover the regression model parameters. Then, we further present a single-phase spectral algorithm to jointly recover the topic distribution matrix as well as the regression weights. Our spectral algorithms are provably correct and computationally efficient. We prove a sample complexity bound for each algorithm and subsequently derive a sufficient condition for the identifiability of sLDA. Thorough experiments on synthetic and real-world datasets verify the theory and demonstrate the practical effectiveness of the spectral algorithms. In fact, our results on a large-scale review rating dataset demonstrate that our single-phase spectral algorithm alone gets comparable or even better performance than state-of-the-art methods, while previous work on spectral methods has rarely reported such promising performance.

Image Re-Ranking Based on Topic Diversity.

Science.gov (United States)

Qian, Xueming; Lu, Dan; Wang, Yaxiong; Zhu, Li; Tang, Yuan Yan; Wang, Meng

2017-08-01

Social media sharing Websites allow users to annotate images with free tags, which significantly contribute to the development of the web image retrieval. Tag-based image search is an important method to find images shared by users in social networks. However, how to make the top ranked result relevant and with diversity is challenging. In this paper, we propose a topic diverse ranking approach for tag-based image retrieval with the consideration of promoting the topic coverage performance. First, we construct a tag graph based on the similarity between each tag. Then, the community detection method is conducted to mine the topic community of each tag. After that, inter-community and intra-community ranking are introduced to obtain the final retrieved results. In the inter-community ranking process, an adaptive random walk model is employed to rank the community based on the multi-information of each topic community. Besides, we build an inverted index structure for images to accelerate the searching process. Experimental results on Flickr data set and NUS-Wide data sets show the effectiveness of the proposed approach.

Recent topics in NMR imaging and MRI

International Nuclear Information System (INIS)

Watanabe, Tokuko

2002-01-01

NMR and NMR imaging (MRI) are finding increasing use not only in the clinical and medical fields, but also in material, physicochemical, biological, geological, industrial and environmental applications. This short review is limited to two topics: new techniques and pulse sequences and their application to non-clinical fields that may have clinical application; and new trends in MR contrast agents. The former topic addresses pulse sequence and data analysis; dynamics such as diffusion, flow, velocity and velocimetry; chemometrics; pharmacological agents; and chemotherapy; the latter topic addresses contrast agents (CA) sensitive to biochemical activity; CA based on water exchange; molecular interactions and stability of CA; characteristics of emerging CA; superparamagnetic CA; and macromolecular CA. (author)

Mapping land cover through time with the Rapid Land Cover Mapper—Documentation and user manual

Science.gov (United States)

Cotillon, Suzanne E.; Mathis, Melissa L.

2017-02-15

The Rapid Land Cover Mapper is an Esri ArcGIS® Desktop add-in, which was created as an alternative to automated or semiautomated mapping methods. Based on a manual photo interpretation technique, the tool facilitates mapping over large areas and through time, and produces time-series raster maps and associated statistics that characterize the changing landscapes. The Rapid Land Cover Mapper add-in can be used with any imagery source to map various themes (for instance, land cover, soils, or forest) at any chosen mapping resolution. The user manual contains all essential information for the user to make full use of the Rapid Land Cover Mapper add-in. This manual includes a description of the add-in functions and capabilities, and step-by-step procedures for using the add-in. The Rapid Land Cover Mapper add-in was successfully used by the U.S. Geological Survey West Africa Land Use Dynamics team to accurately map land use and land cover in 17 West African countries through time (1975, 2000, and 2013).

Continuous outreach activities performed by a student project team of undergraduates and their program topics in optics and photonics

Science.gov (United States)

Hasegawa, Makoto; Tokumitsu, Seika

2016-09-01

The out-of-curriculum project team "Rika-Kobo", organized by undergraduate students, has been actively engaged in a variety of continuous outreach activities in the fields of science and technology including optics and photonics. The targets of their activities cover wide ranges of generations from kids to parents and elderly people, with aiming to promote their interests in various fields of science and technologies. This is an out-of-curriculum project team with about 30 to 40 undergraduate students in several grades and majors. The total number of their activities per year tends to reach 80 to 90 in recent years. Typical activities to be performed by the project team include science classes in elementary and/or secondary schools, science classes at other educational facilities such as science museums, and experiment demonstrations at science events. Popular topics cover wide ranges from explanations and demonstrations of nature phenomena, such as rainbow colors, blue sky, sunset color, to demonstration experiments related to engineering applications, such as polarization of light, LEDs, and optical communications. Experimental topics in optics and photonics are especially popular to the audiences. Those activities are very effective to enhance interests of the audiences in learning related knowledges, irrespective of their generations. Those activities are also helpful for the student members to achieve and/or renew scientific knowledges. In addition, each of the activities provides the student members with effective and advantageous Project-Based-Learning (PBL) style experiences including manufacturing experiences, which are advantageous to cultivate their engineering skills.

Exploring the Multifaceted Topic of Climate Change in Our Changing Climate and Living With Our Changing Climate

Science.gov (United States)

Brey, J. A.; Kauffman, C.; Geer, I. W.; Mills, E. W.; Nugnes, K. A.; Stimach, A. E.

2015-12-01

As the effects of climate change become more profound, climate literacy becomes increasingly important. The American Meteorological Society (AMS) responds to this need through the publication of Our Changing Climate and Living With Our Changing Climate. Both publications incorporate the latest scientific understandings of Earth's climate system from reports such as IPCC AR5 and the USGCRP's Third National Climate Assessment. Topic In Depth sections appear throughout each chapter and lead to more extensive, multidisciplinary information related to various topics. Additionally, each chapter closes with a For Further Exploration essay, which addresses specific topics that complement a chapter concept. Web Resources, which encourage additional exploration of chapter content, and Scientific Literature, from which chapter content was derived can also be found at the conclusion of each chapter. Our Changing Climate covers a breadth of topics, including the scientific principles that govern Earth's climate system and basic statistics and geospatial tools used to investigate the system. Released in fall 2015, Living With Our Changing Climate takes a more narrow approach and investigates human and ecosystem vulnerabilities to climate change, the role of energy choices in affecting climate, actions humans can take through adaption, mitigation, and policy to lessen vulnerabilities, and psychological and financial reasons behind climate change denial. While Living With Our Changing Climate is intended for programs looking to add a climate element into their curriculum, Our Changing Climate is part of the AMS Climate Studies course. In a 2015 survey of California University of Pennsylvania undergraduate students using Our Changing Climate, 82% found it comfortable to read and utilized its interactive components and resources. Both ebooks illuminate the multidisciplinary aspect of climate change, providing the opportunity for a more sustainable future.

Sexual Problems in Men: MedlinePlus Health Topic

Science.gov (United States)

... Spanish Retrograde ejaculation (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Sexual Problems in ... Premature ejaculation Reifenstein syndrome Retrograde ejaculation Related Health Topics Erectile Dysfunction Penis Disorders Prostate Diseases Testicular Disorders ...

Cancer--Living with Cancer: MedlinePlus Health Topic

Science.gov (United States)

... during cancer treatment (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Cancer--Living with ... care plan Show More Show Less Related Health Topics Cancer Cancer Chemotherapy Palliative Care National Institutes of ...

Full Text or Abstract? : Examining Topic Coherence Scores Using Latent Dirichlet Allocation

NARCIS (Netherlands)

Syed, S.; Spruit, M.

2017-01-01

This paper assesses topic coherence and human topic ranking of uncovered latent topics from scientific publications when utilizing the topic model latent Dirichlet allocation (LDA) on abstract and full-text data. The coherence of a topic, used as a proxy for topic quality, is based on the

Infantile generalized hypertrichosis caused by topical minoxidil.

Science.gov (United States)

Rampon, Greice; Henkin, Caroline; de Souza, Paulo Ricardo Martins; Almeida, Hiram Larangeira de

2016-01-01

Rare cases of hypertrichosis have been associated with topically applied minoxidil. We present the first reported case in the Brazilian literature of generalized hypertrichosis affecting a 5-year-old child, following use of minoxidil 5%, 20 drops a day, for hair loss. The laboratory investigation excluded hyperandrogenism and thyroid dysfunction. Topical minoxidil should be used with caution in children.

Climate under cover

CERN Document Server

Takakura, Tadashi

2002-01-01

1.1. INTRODUCTION Plastic covering, either framed or floating, is now used worldwide to protect crops from unfavorable growing conditions, such as severe weather and insects and birds. Protected cultivation in the broad sense, including mulching, has been widely spread by the innovation of plastic films. Paper, straw, and glass were the main materials used before the era of plastics. Utilization of plastics in agriculture started in the developed countries and is now spreading to the developing countries. Early utilization of plastic was in cold regions, and plastic was mainly used for protection from the cold. Now plastic is used also for protection from wind, insects and diseases. The use of covering techniques started with a simple system such as mulching, then row covers and small tunnels were developed, and finally plastic houses. Floating mulch was an exception to this sequence: it was introduced rather recently, although it is a simple structure. New development of functional and inexpensive films trig...

Alternative cover design

International Nuclear Information System (INIS)

1988-11-01

The special study on Alternative Cover Designs is one of several studies initiated by the US Department of Energy (DOE) in response to the proposed US Environmental Protection Agency (EPA) groundwater standards. The objective of this study is to investigate the possibility of minimizing the infiltration of precipitation through stabilized tailings piles by altering the standard design of covers currently used on the Uranium Mill Tailings Remedial Action (UMTRA) Project. Prior. to the issuance of the proposed standards, UMTRA Project piles had common design elements to meet the required criteria, the most important of which were for radon diffusion, long-term stability, erosion protection, and groundwater protection. The standard pile covers consisted of three distinct layers. From top to bottom they were: rock for erosion protection; a sand bedding layer; and the radon barrier, usually consisting of a clayey sand material, which also functioned to limit infiltration into the tailings. The piles generally had topslopes from 2 to 4 percent and sideslopes of 20 percent

Benthic Cover

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Benthic cover (habitat) maps are derived from aerial imagery, underwater photos, acoustic surveys, and data gathered from sediment samples. Shallow to moderate-depth...

Special study on vegetative covers

International Nuclear Information System (INIS)

1988-11-01

This report describes the findings of a special study on the use of vegetative covers to stabilize tailings piles for the Uranium Mill Tailings Remedial Action (UMTRA) Project. The principal rationale for using plants would be to establish a dynamic system for controlling water balance. Specifically, vegetation would be used to intercept and transpire precipitation to the atmosphere, rather than allowing water to drain into the tailings and mobilize contaminants. This would facilitate compliance with groundwater standards proposed for the UMTRA Project by the Environmental Protection Agency. The goals of the study were to evaluate the feasibility of using vegetative covers on UMTRA Project piles, define the advantages and disadvantages of vegetative covers, and develop general guidelines for their use when such use seems reasonable. The principal method for the study was to analyze and apply to the UMTRA Project the results of research programs on vegetative covers at other US Department of Energy (DOE) waste management facilities. The study also relied upon observations made of existing stabilized piles at UMTRA Project sites where natural vegetation is growing on the rock-covered surfaces. Water balance and erosion models were also used to quantify the long-term performance of vegetative covers planned for the topslopes of stabilized piles at Grand Junction and Durango, Colorado, two UMTRA Project sites where the decision was made during the course of this special study to use vegetative covers. Elements in the design and construction of the vegetative covers at these two sites are discussed in the report, with explanations of the differing features that reflect differing environmental conditions. 28 refs., 18 figs., 9 tabs

Evaluation of burial ground soil covers

International Nuclear Information System (INIS)

Fenimore, J.W.

1976-11-01

Solid radioactive waste burial at the Savannah River Plant between 1955 and 1972 filled a 76-acre site. Burial operations then were shifted to an adjacent site, and a program was begun to develop a land cover that would: (1) minimize soil erosion; and (2) protect the buried waste from deep-rooted plants, since radionuclides can be recycled by uptake through root systems. In anticipation of the need for a suitable soil cover, five grass species were planted on 20 plots (4 plots of each species) at the burial ground (Facility 643-G) in 1969. The grass plots were planted for evaluation of viability, root depth, and erosion protection existing under conditions of low fertility and minimum care. In addition, 16 different artificial soil covers were installed on 32 plots (each cover on two plots) to evaluate: (1) resistance of cover to deterioration from weathering; (2) resistance of cover to encroachment by deep-rooted plants; and (3) soil erosion protection provided by the cover. All test plots were observed and photographed in 1970 and in 1974. After both grass and artificial soil covers were tested five years, the following results were observed: Pensacola Bahia grass was the best of the five cover grasses tested; and fifteen of the sixteen artificial covers that were tested controlled vegetation growth and soil erosion. Photographs of the test plots will be retaken at five-year intervals for future documentation

Spontaneous Coronary Artery Dissection following Topical Hormone Replacement Therapy

Directory of Open Access Journals (Sweden)

Alexander L. Pan

2012-01-01

Full Text Available Spontaneous coronary artery dissection is a rare condition, usually presenting as an acute coronary syndrome, and is often seen in states associated with high systemic estrogen levels such as pregnancy or oral contraceptive use. While topical hormonal replacement therapy may result in increased estrogen levels similar to those documented with oral contraceptive use, there are no reported cases of spontaneous coronary dissection with topical hormonal replacement therapy. We describe a 53-year-old female who developed two spontaneous coronary dissections while on topical hormonal replacement therapy. The patient had no other risk factors for coronary dissection. After withdrawal from topical hormonal therapy, our patient has done well and has not had recurrent coronary artery dissections over a one-year follow-up period. The potential contributory role of topical hormonal therapy as a cause of spontaneous coronary dissection should be recognized.

Optimal shortening of uniform covering arrays.

Directory of Open Access Journals (Sweden)

Jose Torres-Jimenez

Full Text Available Software test suites based on the concept of interaction testing are very useful for testing software components in an economical way. Test suites of this kind may be created using mathematical objects called covering arrays. A covering array, denoted by CA(N; t, k, v, is an N × k array over [Formula: see text] with the property that every N × t sub-array covers all t-tuples of [Formula: see text] at least once. Covering arrays can be used to test systems in which failures occur as a result of interactions among components or subsystems. They are often used in areas such as hardware Trojan detection, software testing, and network design. Because system testing is expensive, it is critical to reduce the amount of testing required. This paper addresses the Optimal Shortening of Covering ARrays (OSCAR problem, an optimization problem whose objective is to construct, from an existing covering array matrix of uniform level, an array with dimensions of (N - δ × (k - Δ such that the number of missing t-tuples is minimized. Two applications of the OSCAR problem are (a to produce smaller covering arrays from larger ones and (b to obtain quasi-covering arrays (covering arrays in which the number of missing t-tuples is small to be used as input to a meta-heuristic algorithm that produces covering arrays. In addition, it is proven that the OSCAR problem is NP-complete, and twelve different algorithms are proposed to solve it. An experiment was performed on 62 problem instances, and the results demonstrate the effectiveness of solving the OSCAR problem to facilitate the construction of new covering arrays.

Do scientists trace hot topics?

Science.gov (United States)

Wei, Tian; Li, Menghui; Wu, Chensheng; Yan, Xiao-Yong; Fan, Ying; Di, Zengru; Wu, Jinshan

2013-01-01

Do scientists follow hot topics in their scientific investigations? In this paper, by performing analysis to papers published in the American Physical Society (APS) Physical Review journals, it is found that papers are more likely to be attracted by hot fields, where the hotness of a field is measured by the number of papers belonging to the field. This indicates that scientists generally do follow hot topics. However, there are qualitative differences among scientists from various countries, among research works regarding different number of authors, different number of affiliations and different number of references. These observations could be valuable for policy makers when deciding research funding and also for individual researchers when searching for scientific projects.

Influence of cover defects on the attenuation of radon with earthen covers

International Nuclear Information System (INIS)

Kalkwarf, D.R.; Mayer, D.W.

1983-11-01

Experimental and theoretical evaluations of radon flux through laboratory-scale defective soil columns are presented together with a survey of literature on the formation and prevention of defects in soil covers. This report focuses on air-filled, centimeter-scale defects that are most probable in earthen covers for attenuating radon emission from uranium-mill tailings. Examples include shirnkage and erosion cracks, erosion piping, animal burrows and air channels formed by the biodegradation of vegetation roots. Calculations based on mathematical models indicate that collections of defects which could increase the radon flux from an earthen cover by a factor of two would be easily detected by visual inspection. However, these models ignore air-turbulence in the defect and drying of the soil around the defect. Laboratory measurements showed that turbulent diffusion of radon occurred through defects as narrow as 0.3 cm when subjected to a transverse air velocity of 1 to 6 miles per hour at the surface. Both turbulence and more-rapid drying of soil can accelerate radon flux to the cover surface. Consequently, recommended methods to inhibit defect formation should be applied. 29 references, 3 figures, 5 tables

Comparison of topical sucralfate and silver sulfadiazine cream in second degree burns in rats.

Science.gov (United States)

Beheshti, Akram; Shafigh, Younes; Zangivand, Amir-Abdollah; Samiee-Rad, Fatemeh; Hassanzadeh, Gholamreza; Shafigh, Navid

2013-01-01

The most prevalent topical treatment for partial thickness burns is silver sulfadiazine 1% (SSD). Recent studies have shown that the healing of partial thickness burns is delayed with the use of SSD. One of the potential burn dressings is sucralfate. With this study the authors have aimed to analyze comparatively the effects of sucralfate and SSD on second degree burn wounds in rats. Forty-eight male rats were divided into three equal groups. A burn model was constituted on the back of all rats. The burned areas in the first, second and third groups were covered daily with sucralfate, SSD and cold cream (control), respectively. At the end of the 7th, 14th, 21st and 28th day, the rats were anesthetized and the burned skin tissue samples were collected for histopathological examination. At the end of the study, the epidermis and horny layer was completely formed in the SSD and sucralfate group; however the appendix of skin was just formed in the sucralfate group. Also the percentage of wound healing was calculated at 76%, 91% and 100% respectively in the control, silver sulfadiazine and sucralfate groups. Sucralfate is known to have multiple beneficial effects on wound healing. Using topical sucralfate accelerates the burn wound healing process in comparison with both the control and SSD groups and can be used as an adjunctive or alternative agent in the future.

The efficacy of topical Royal Jelly on diabetic foot ulcers healing: A case series

Directory of Open Access Journals (Sweden)

Mansour Siavash

2011-01-01

Full Text Available Background: Foot ulcers and infections are the major sources of morbidity in individuals with diabetes mellitus. This study aimed to evaluate the efficacy of topical Royal Jelly (a worker honey bee product on healing diabetic foot ulcers. Methods: Diabetic patients with foot ulcers that were referred to our clinic at Khorshid Hospital, Isfahan, Iran; were evaluated three times a week and treated according to standard treatments consisted of offloading, infection control, vascular improvement and debridement if required. In addition, all ulcers were measured and then topical sterile 5% Royal Jelly was applied on the total surface area of the wounds. Eventually, they were covered with sterile dressings. Each patient was followed for a period of three months or until the complete healing. Results: A total of eight patients were enrolled in this study. Of these, two had two ulcers and, therefore, ten ulcers were evaluated. Two ulcers were excluded. Seven of the remained eight ulcers healed. Mean duration of complete healing was 41 days. One ulcer did not completely heal but improved to 40% smaller in length, 32% in width and 28% in depth. The mean length, width and depth reduction rates were 0.35 mm/day, 0.28 mm/day and 0.11 mm/day, respectively. Conclusions: Royal Jelly dressing may be an effective method for treating diabetic foot ulcers besides standard treatments.

Infantile generalized hypertrichosis caused by topical minoxidil*

Science.gov (United States)

Rampon, Greice; Henkin, Caroline; de Souza, Paulo Ricardo Martins; de Almeida Jr, Hiram Larangeira

2016-01-01

Rare cases of hypertrichosis have been associated with topically applied minoxidil. We present the first reported case in the Brazilian literature of generalized hypertrichosis affecting a 5-year-old child, following use of minoxidil 5%, 20 drops a day, for hair loss. The laboratory investigation excluded hyperandrogenism and thyroid dysfunction. Topical minoxidil should be used with caution in children. PMID:26982785

Relativity theory - topical

International Nuclear Information System (INIS)

Schmutzer, E.

1979-01-01

Issued on the occasion of Albert Einstein's 100th birthday the book deals topically with the special and general relativity theory. The latest experiments to confirm the relativity theory are described and the historical development of the theory is presented in detail. Emphasis is given to the disclosure of deep insights into the nature of matter. Of interest to experts in physical and natural sciences and to mathematicians

[Snow cover pollution monitoring in Ufa].

Science.gov (United States)

Daukaev, R A; Suleĭmanov, R A

2008-01-01

The paper presents the results of examining the snow cover polluted with heavy metals in the large industrial town of Ufa. The level of man-caused burden on the snow cover of the conventional parts of the town was estimated and compared upon exposure to a wide range of snow cover pollutants. The priority snow cover pollutants were identified among the test heavy metals.

Hiding data selected topics : Rudolf Ahlswede’s lectures on information theory 3

CERN Document Server

Althöfer, Ingo; Deppe, Christian; Tamm, Ulrich

2016-01-01

Devoted to information security, this volume begins with a short course on cryptography, mainly based on lectures given by Rudolf Ahlswede at the University of Bielefeld in the mid 1990s. It was the second of his cycle of lectures on information theory which opened with an introductory course on basic coding theorems, as covered in Volume 1 of this series. In this third volume, Shannon’s historical work on secrecy systems is detailed, followed by an introduction to an information-theoretic model of wiretap channels, and such important concepts as homophonic coding and authentication. Once the theoretical arguments have been presented, comprehensive technical details of AES are given. Furthermore, a short introduction to the history of public-key cryptology, RSA and El Gamal cryptosystems is provided, followed by a look at the basic theory of elliptic curves, and algorithms for efficient addition in elliptic curves. Lastly, the important topic of “oblivious transfer” is discussed, which is strongly conne...

Plant invasions in China: an emerging hot topic in invasion science

Directory of Open Access Journals (Sweden)

Jian Liu

2012-12-01

Full Text Available China has shown a rapid economic development in recent decades, and several drivers of this change are known to enhance biological invasions, a major cause of biodiversity loss. Here we review the current state of research on plant invasions in China by analyzing papers referenced in the ISI Web of Knowledge. Since 2001, the number of papers has increased exponentially, indicating that plant invasions in China are an emerging hot topic in invasion science. The analyzed papers cover a broad range of methodological approaches and research topics. While more that 250 invasive plant species with negative impacts have been reported from China, only a few species have been considered in more than a handful of papers (in order of decreasing number of references: Spartina alterniflora, Ageratina adenophora, Mikania micrantha, Alternanthera philoxeroides, Solidago canadensis, Eichhornia crassipes. Yet this selection might rather reflect the location of research teams than the most invasive plant species in China. Considering the previous achievements in China found in our analysis research in plant invasions could be expanded by (1 compiling comprehensive lists of non-native plant species at the provincial and national scales and to include species that are native to one part of China but non-native to others in these lists; (2 strengthening pathways studies (primary introduction to the country, secondary releases within the country to enhance prevention and management; and (3 assessing impacts of invasive species at different spatial scales (habitats, regions and in relation to conservation resources.

Radiation risks -a possible teaching topic

International Nuclear Information System (INIS)

Howes, R.W.

1975-01-01

Radiation risks has been the subject of hot debate since 1969 due in main to the energy crisis and the switch to nuclear power. Topics of this debate including; the controversy concerned with the late radiobiological effects of low level radiation, the social responsibility of modern scientists, the sometimes acrimonious discussion which has taken place over many years concerning radiation standards, and present day misgivings over the environmental aspect of the nuclear power programme, are discussed and suggestions are made of ways in which the topics could be introduced into teaching courses. (U.K.)

Efficacy of adding topical simvastatin to topical calcipotriol on improvement of cutaneous plaque psoriasis

Directory of Open Access Journals (Sweden)

Fariba Iraji

2014-01-01

Conclusion: This study indicates that topical simvastatin is not associated with significant impacts in the treatment of psoriasis as compared to oral form. This study indicates that psoriasis is a systemic disorder with variable skin manifestations.

Nuclear safety - Topical issues

International Nuclear Information System (INIS)

1995-01-01

The following topical issues related to nuclear safety are discussed: steam generators; maintenance strategies; control rod drive nozzle cracks; core shrouds cracks; sump strainer blockage; fire protection; computer software important for safety; safety during shutdown; operational safety experience; external hazards and other site related issues. 5 figs, 5 tabs

Real-time topic-aware influence maximization using preprocessing.

Science.gov (United States)

Chen, Wei; Lin, Tian; Yang, Cheng

2016-01-01

Influence maximization is the task of finding a set of seed nodes in a social network such that the influence spread of these seed nodes based on certain influence diffusion model is maximized. Topic-aware influence diffusion models have been recently proposed to address the issue that influence between a pair of users are often topic-dependent and information, ideas, innovations etc. being propagated in networks are typically mixtures of topics. In this paper, we focus on the topic-aware influence maximization task. In particular, we study preprocessing methods to avoid redoing influence maximization for each mixture from scratch. We explore two preprocessing algorithms with theoretical justifications. Our empirical results on data obtained in a couple of existing studies demonstrate that one of our algorithms stands out as a strong candidate providing microsecond online response time and competitive influence spread, with reasonable preprocessing effort.

Combinatorial aspects of covering arrays

Directory of Open Access Journals (Sweden)

Charles J. Colbourn

2004-11-01

Full Text Available Covering arrays generalize orthogonal arrays by requiring that t -tuples be covered, but not requiring that the appearance of t -tuples be balanced.Their uses in screening experiments has found application in software testing, hardware testing, and a variety of fields in which interactions among factors are to be identified. Here a combinatorial view of covering arrays is adopted, encompassing basic bounds, direct constructions, recursive constructions, algorithmic methods, and applications.

Forest Cover Estimation in Ireland Using Radar Remote Sensing: A Comparative Analysis of Forest Cover Assessment Methodologies

Science.gov (United States)

Devaney, John; Barrett, Brian; Barrett, Frank; Redmond, John; O`Halloran, John

2015-01-01

Quantification of spatial and temporal changes in forest cover is an essential component of forest monitoring programs. Due to its cloud free capability, Synthetic Aperture Radar (SAR) is an ideal source of information on forest dynamics in countries with near-constant cloud-cover. However, few studies have investigated the use of SAR for forest cover estimation in landscapes with highly sparse and fragmented forest cover. In this study, the potential use of L-band SAR for forest cover estimation in two regions (Longford and Sligo) in Ireland is investigated and compared to forest cover estimates derived from three national (Forestry2010, Prime2, National Forest Inventory), one pan-European (Forest Map 2006) and one global forest cover (Global Forest Change) product. Two machine-learning approaches (Random Forests and Extremely Randomised Trees) are evaluated. Both Random Forests and Extremely Randomised Trees classification accuracies were high (98.1–98.5%), with differences between the two classifiers being minimal (forest area and an increase in overall accuracy of SAR-derived forest cover maps. All forest cover products were evaluated using an independent validation dataset. For the Longford region, the highest overall accuracy was recorded with the Forestry2010 dataset (97.42%) whereas in Sligo, highest overall accuracy was obtained for the Prime2 dataset (97.43%), although accuracies of SAR-derived forest maps were comparable. Our findings indicate that spaceborne radar could aid inventories in regions with low levels of forest cover in fragmented landscapes. The reduced accuracies observed for the global and pan-continental forest cover maps in comparison to national and SAR-derived forest maps indicate that caution should be exercised when applying these datasets for national reporting. PMID:26262681

Topical minoxidil: cardiac effects in bald man.

Science.gov (United States)

Leenen, F H; Smith, D L; Unger, W P

1988-01-01

Systemic cardiovascular effects during chronic treatment with topical minoxidil vs placebo were evaluated using a double-blind, randomized design for two parallel groups (n = 20 for minoxidil, n = 15 for placebo). During 6 months of follow-up, blood pressure did not change, whereas minoxidil increased heart rate by 3-5 beats min-1. Compared with placebo, topical minoxidil caused significant increases in LV end-diastolic volume, in cardiac output (by 0.751 min-1) and in LV mass (by 5 g m-2). We conclude that in healthy subjects short-term use of topical minoxidil is likely not to be detrimental. However, safety needs to be established regarding ischaemic symptoms in patients with coronary artery disease as well as for the possible development of LV hypertrophy in healthy subjects during years of therapy. PMID:3191000

Medical adherence to topical corticosteroid preparations prescribed for psoriasis

DEFF Research Database (Denmark)

Svendsen, Mathias Tiedemann; Andersen, Flemming; Hansen, Jakob

2017-01-01

OBJECTIVE: Topical corticosteroids and corticosteroid combinations are the principal treatments in psoriasis. The aim of this study was to investigate published literature dealing with medical adherence to topical corticosteroid or corticosteroid combinations in patients with psoriasis. MATERIALS...... health outcome in topical treatment of psoriasis, further studies should be conducted addressing determinants of nonadherence and test interventions to improve adherence. Validated measurements of medical nonadherence, prescription registers, or medication-weight are needed....

Topical erythropoietin promotes wound repair in diabetic rats.

Science.gov (United States)

Hamed, Saher; Ullmann, Yehuda; Masoud, Muhannad; Hellou, Elias; Khamaysi, Ziad; Teot, Luc

2010-01-01

Wound healing in diabetic patients is slower than in healthy individuals. Erythropoietin (EPO) has non-hemopoietic targets in the skin, and systemically administered EPO promotes wound healing in experimental animals. This study investigated the effect of topical EPO treatment on defective wound repair in the skin of diabetic rats. Full-thickness excisional skin wounds were made in 38 rats, of which 30 had diabetes. The wounds were then treated topically with a cream that contained either vehicle, 600 IU ml(-1) EPO (low dose), or 3,000 IU ml(-1) (high dose) EPO. We assessed the rate of wound closure during the 12-day treatment period, and microvascular density (MVD), vascular endothelial growth factor (VEGF), and hydroxyproline (HP) contents, and the extent of apoptosis in wound tissues at the end of the 12-day treatment period. Topical EPO treatment significantly reduced the time to final wound closure. This increased rate of closure of the two EPO-treated wounds in diabetic rats was associated with increased MVD, VEGF, and HP contents, and a reduced extent of apoptosis. In light of our finding that topical EPO treatment promotes skin wound repair in diabetic rats, we propose that topical EPO treatment is a therapeutically beneficial method of treating chronic diabetic wounds.

Comparative evaluation of topical Sodium fusidate cream in common pyodermas with topical gentamicin ointment and systemic antibiotics

Directory of Open Access Journals (Sweden)

Roy AK

1996-01-01

Full Text Available ABSTRACT: One hundred cases of common pyodermas consisting of four groups, namely impetigo, furunculosis and chronic folliculitis were taken. Each group containing twenty five cases were divided again into three subgroups. From each group, 15 were treated with 2 percent Sodium fusidate cream, 5 were with 0.1 percent Gentamycin sulphate cream and the rest 5 with systemic Erythromycin stearate. In the group of Impetigo, Bockhart′s Impetigo and Furunculosis, topical Sodium fusidate cream showed excellent result, better than Gentamycin topical and equal to that of systemic Erythromycin stearate.

Characters and Topical Diversity

DEFF Research Database (Denmark)

Eriksson, Rune

2014-01-01

The purpose of this article is to contribute to our understanding of the difference between the bestseller and the non-bestseller in nonfiction. It is noticed that many bestsellers in nonfiction belongs to the sub-genre of creative nonfiction, but also that the topics in this kind of literature i...

Analysis and application of opinion model with multiple topic interactions.

Science.gov (United States)

Xiong, Fei; Liu, Yun; Wang, Liang; Wang, Ximeng

2017-08-01

To reveal heterogeneous behaviors of opinion evolution in different scenarios, we propose an opinion model with topic interactions. Individual opinions and topic features are represented by a multidimensional vector. We measure an agent's action towards a specific topic by the product of opinion and topic feature. When pairs of agents interact for a topic, their actions are introduced to opinion updates with bounded confidence. Simulation results show that a transition from a disordered state to a consensus state occurs at a critical point of the tolerance threshold, which depends on the opinion dimension. The critical point increases as the dimension of opinions increases. Multiple topics promote opinion interactions and lead to the formation of macroscopic opinion clusters. In addition, more topics accelerate the evolutionary process and weaken the effect of network topology. We use two sets of large-scale real data to evaluate the model, and the results prove its effectiveness in characterizing a real evolutionary process. Our model achieves high performance in individual action prediction and even outperforms state-of-the-art methods. Meanwhile, our model has much smaller computational complexity. This paper provides a demonstration for possible practical applications of theoretical opinion dynamics.

Topic structure for information retrieval

NARCIS (Netherlands)

He, J.; Sanderson, M.; Zhai, C.; Zobel, J.; Allan, J.; Aslam, J.A.

2009-01-01

In my research, I propose a coherence measure, with the goal of discovering and using topic structures within and between documents, of which I explore its extensions and applications in information retrieval.

Covered Bridge Security Manual

Science.gov (United States)

Brett Phares; Terry Wipf; Ryan Sievers; Travis Hosteng

2013-01-01

The design, construction, and use of covered timber bridges is all but a lost art in these days of pre-stressed concrete, high-performance steel, and the significant growth both in the volume and size of vehicles. Furthermore, many of the existing covered timber bridges are preserved only because of their status on the National Registry of Historic Places or the...

Generative Topic Modeling in Image Data Mining and Bioinformatics Studies

Science.gov (United States)

Chen, Xin

2012-01-01

Probabilistic topic models have been developed for applications in various domains such as text mining, information retrieval and computer vision and bioinformatics domain. In this thesis, we focus on developing novel probabilistic topic models for image mining and bioinformatics studies. Specifically, a probabilistic topic-connection (PTC) model…

The effect of an interactive e-drug calculations package on nursing students' drug calculation ability and self-efficacy.

Science.gov (United States)

McMullan, Miriam; Jones, Ray; Lea, Susan

2011-06-01

Nurses need to be competent and confident in performing drug calculations to ensure patient safety. The purpose of this study is to compare an interactive e-drug calculations package, developed using Cognitive Load Theory as its theoretical framework, with traditional handout learning support on nursing students' drug calculation ability, self-efficacy and support material satisfaction. A cluster randomised controlled trial comparing the e-package with traditional handout learning support was conducted with a September cohort (n=137) and a February cohort (n=92) of second year diploma nursing students. Students from each cohort were geographically dispersed over 3 or 4 independent sites. Students from each cohort were invited to participate, halfway through their second year, before and after a 12 week clinical practice placement. During their placement the intervention group received the e-drug calculations package while the control group received traditional 'handout' support material. Drug calculation ability and self-efficacy tests were given to the participants pre- and post-intervention. Participants were given the support material satisfaction scale post-intervention. Students in both cohorts randomised to e-learning were more able to perform drug calculations than those receiving the handout (September: mean 48.4% versus 34.7%, p=0.027; February: mean 47.6% versus 38.3%, p=0.024). February cohort students using the e-package were more confident in performing drug calculations than those students using handouts (self-efficacy mean 56.7% versus 45.8%, p=0.022). There was no difference in improved self-efficacy between intervention and control for students in the September cohort. Students who used the package were more satisfied with its use than the students who used the handout (mean 29.6 versus 26.5, p=0.001), particularly with regard to the package enhancing their learning (p=0.023), being an effective way to learn (p=0.005), providing practice and

Progressive Learning of Topic Modeling Parameters: A Visual Analytics Framework.

Science.gov (United States)

El-Assady, Mennatallah; Sevastjanova, Rita; Sperrle, Fabian; Keim, Daniel; Collins, Christopher

2018-01-01

Topic modeling algorithms are widely used to analyze the thematic composition of text corpora but remain difficult to interpret and adjust. Addressing these limitations, we present a modular visual analytics framework, tackling the understandability and adaptability of topic models through a user-driven reinforcement learning process which does not require a deep understanding of the underlying topic modeling algorithms. Given a document corpus, our approach initializes two algorithm configurations based on a parameter space analysis that enhances document separability. We abstract the model complexity in an interactive visual workspace for exploring the automatic matching results of two models, investigating topic summaries, analyzing parameter distributions, and reviewing documents. The main contribution of our work is an iterative decision-making technique in which users provide a document-based relevance feedback that allows the framework to converge to a user-endorsed topic distribution. We also report feedback from a two-stage study which shows that our technique results in topic model quality improvements on two independent measures.

Summary of decontamination cover manufacturing experience

International Nuclear Information System (INIS)

Ulrich, G.B.; Berry, H.W.

1995-02-01

Decontamination cover forming cracks and vent cup assembly leaks through the decontamination covers were early manufacturing problems. The decontamination cover total manufacturing process yield was as low as 55%. Applicable tooling and procedures were examined. All manufacturing steps from foil fabrication to final assembly leak testing were considered as possible causes or contributing factors to these problems. The following principal changes were made to correct these problems: (1) the foil annealing temperature was reduced from 1375 degrees to 1250 degrees C, (2) the decontamination cover fabrication procedure (including visual inspection for surface imperfections and elimination of superfluous operations) was improved, (3) the postforming dye penetrant inspection procedure was revised for increased sensitivity, (4) a postforming (prewelding) 1250 degrees C/1 h vacuum stress-relief operation was added, (5) a poststress relief (prewelding) decontamination cover piece-part leak test was implemented, (6) the hold-down fixture used during the decontamination cover-to-cup weld was modified, and concomitantly, and (7) the foil fabrication process was changed from the extruding and rolling of 63-mm-diam vacuum arc-remelted ingots (extrusion process) to the rolling of 19-mm-square arc-melted drop castings (drop cast process). Since these changes were incorporated, the decontamination cover total manufacturing process yield has been 91 %. Most importantly, more than 99% of the decontamination covers welded onto vent cup assemblies were acceptable. The drastic yield improvement is attributed primarily to the change in the foil annealing temperature from 1375 degrees to 1250 degrees C and secondarily to the improvements in the decontamination cover fabrication procedure

RUPS: Research Utilizing Problem Solving. Administrators Version. Participant Materials.

Science.gov (United States)

Jung, Charles; And Others

These materials are the handouts for school administrators participating in RUPS (Research Utilizing Problem Solving) workshops. The purposes of the workshops are to develop skills for improving schools and to increase teamwork skills. The handouts correspond to the 16 subsets that make up the five-day workshop: (1) orientation; (2) identifying…

Selected topics in nuclear structure

International Nuclear Information System (INIS)

1994-01-01

The collection of abstracts on selected topics in nuclear structure are given. Special attention pays to collective excitations and high-spin states of nuclei, giant resonance structure, nuclear reaction mechanisms and so on

Sensitivity of selected landscape pattern metrics to land-cover misclassification and differences in land-cover composition

Science.gov (United States)

James D. Wickham; Robert V. O' Neill; Kurt H. Riitters; Timothy G. Wade; K. Bruce Jones

1997-01-01

Calculation of landscape metrics from land-cover data is becoming increasingly common. Some studies have shown that these measurements are sensitive to differences in land-cover composition, but none are known to have tested also their a sensitivity to land-cover misclassification. An error simulation model was written to test the sensitivity of selected land-scape...

Topical anti-infective sinonasal irrigations: update and literature review.

Science.gov (United States)

Lee, Jivianne T; Chiu, Alexander G

2014-01-01

Sinonasal anti-infective irrigations have emerged as a promising therapeutic modality in the comprehensive management of chronic rhinosinusitis (CRS), particularly in the context of recalcitrant disease. The purpose of this article was to delineate the current spectrum of topical anti-infective therapies available and evaluate their role in the treatment of CRS. A systematic literature review was performed on all studies investigating the use of topical antimicrobial solutions in the medical therapy of CRS. Anti-infective irrigations were stratified into topical antibacterial, antifungal, and additive preparations according to their composition and respective microbicidal properties. The use of topical antibiotic irrigations has been supported by low-level studies in the treatment of refractory CRS, with optimal results achieved in patients who have undergone prior functional endoscopic sinus surgery and received culture-directed therapy. Multiple evidence-based reviews have not established any clinical benefit with the administration of topical antifungals, and their use is not currently recommended in the management of routine CRS. Topical additives including surfactants may be beneficial as adjunctive treatment for recalcitrant CRS, but additional research is needed to investigate their efficacy in comparison with other agents and establish safety profiles. Topical anti-infective solutions are not recommended as first-line therapy for routine CRS but may be considered as a potential option for patients with refractory CRS who have failed traditional medical and surgical intervention. Additional research is necessary to determine which patient populations would derive the most benefit from each respective irrigation regimen and identify potential toxicities associated with prolonged use.

Building bridges across electronic health record systems through inferred phenotypic topics.

Science.gov (United States)

Chen, You; Ghosh, Joydeep; Bejan, Cosmin Adrian; Gunter, Carl A; Gupta, Siddharth; Kho, Abel; Liebovitz, David; Sun, Jimeng; Denny, Joshua; Malin, Bradley

2015-06-01

Data in electronic health records (EHRs) is being increasingly leveraged for secondary uses, ranging from biomedical association studies to comparative effectiveness. To perform studies at scale and transfer knowledge from one institution to another in a meaningful way, we need to harmonize the phenotypes in such systems. Traditionally, this has been accomplished through expert specification of phenotypes via standardized terminologies, such as billing codes. However, this approach may be biased by the experience and expectations of the experts, as well as the vocabulary used to describe such patients. The goal of this work is to develop a data-driven strategy to (1) infer phenotypic topics within patient populations and (2) assess the degree to which such topics facilitate a mapping across populations in disparate healthcare systems. We adapt a generative topic modeling strategy, based on latent Dirichlet allocation, to infer phenotypic topics. We utilize a variance analysis to assess the projection of a patient population from one healthcare system onto the topics learned from another system. The consistency of learned phenotypic topics was evaluated using (1) the similarity of topics, (2) the stability of a patient population across topics, and (3) the transferability of a topic across sites. We evaluated our approaches using four months of inpatient data from two geographically distinct healthcare systems: (1) Northwestern Memorial Hospital (NMH) and (2) Vanderbilt University Medical Center (VUMC). The method learned 25 phenotypic topics from each healthcare system. The average cosine similarity between matched topics across the two sites was 0.39, a remarkably high value given the very high dimensionality of the feature space. The average stability of VUMC and NMH patients across the topics of two sites was 0.988 and 0.812, respectively, as measured by the Pearson correlation coefficient. Also the VUMC and NMH topics have smaller variance of characterizing

Topic Modeling of NASA Space System Problem Reports: Research in Practice

Science.gov (United States)

Layman, Lucas; Nikora, Allen P.; Meek, Joshua; Menzies, Tim

2016-01-01

Problem reports at NASA are similar to bug reports: they capture defects found during test, post-launch operational anomalies, and document the investigation and corrective action of the issue. These artifacts are a rich source of lessons learned for NASA, but are expensive to analyze since problem reports are comprised primarily of natural language text. We apply topic modeling to a corpus of NASA problem reports to extract trends in testing and operational failures. We collected 16,669 problem reports from six NASA space flight missions and applied Latent Dirichlet Allocation topic modeling to the document corpus. We analyze the most popular topics within and across missions, and how popular topics changed over the lifetime of a mission. We find that hardware material and flight software issues are common during the integration and testing phase, while ground station software and equipment issues are more common during the operations phase. We identify a number of challenges in topic modeling for trend analysis: 1) that the process of selecting the topic modeling parameters lacks definitive guidance, 2) defining semantically-meaningful topic labels requires nontrivial effort and domain expertise, 3) topic models derived from the combined corpus of the six missions were biased toward the larger missions, and 4) topics must be semantically distinct as well as cohesive to be useful. Nonetheless,topic modeling can identify problem themes within missions and across mission lifetimes, providing useful feedback to engineers and project managers.

Allegheny County Land Cover Areas

Data.gov (United States)

Allegheny County / City of Pittsburgh / Western PA Regional Data Center — The Land Cover dataset demarcates 14 land cover types by area; such as Residential, Commercial, Industrial, Forest, Agriculture, etc. If viewing this description on...

Getting Started with Topic Modeling and MALLET

Directory of Open Access Journals (Sweden)

Shawn Graham

2012-09-01

Full Text Available In this lesson you will first learn what topic modeling is and why you might want to employ it in your research. You will then learn how to install and work with the MALLET natural language processing toolkit to do so. MALLET involves modifying an environment variable (essentially, setting up a short-cut so that your computer always knows where to find the MALLET program and working with the command line (ie, by typing in commands manually, rather than clicking on icons or menus. We will run the topic modeller on some example files, and look at the kinds of outputs that MALLET installed. This will give us a good idea of how it can be used on a corpus of texts to identify topics found in the documents without reading them individually.

Geometric covers, graph orientations, counter games

DEFF Research Database (Denmark)

Berglin, Edvin

-directed graph is dynamic (can be altered by some outside actor), some orientations may need to be reversed in order to maintain the low out-degree. We present a new algorithm that is simpler than earlier work, yet matches or outperforms the efficiency of these results with very few exceptions. Counter games...... example is Line Cover, also known as Point-Line Cover, where a set of points in a geometric space are to be covered by placing a restricted number of lines. We present new FPT algorithms for the sub-family Curve Cover (which includes Line Cover), as well as for Hyperplane Cover restricted to R 3 (i...... are a type of abstract game played over a set of counters holding values, and these values may be moved between counters according to some set of rules. Typically they are played between two players: the adversary who tries to concentrate the greatest value possible in a single counter, and the benevolent...

Topical medication utilization and health resources consumption in adult patients affected by psoriasis: findings from the analysis of administrative databases of local health units

Directory of Open Access Journals (Sweden)

Perrone V

2017-03-01

Full Text Available Valentina Perrone, Diego Sangiorgi, Stefano Buda, Luca Degli Esposti Clicon S.r.l. Health, Economics & Outcomes Research, Ravenna, Italy Aim: The objectives of this study were to: 1 analyze the drug utilization pattern among adult psoriasis patients who were newly prescribed with topical medication; and 2 assess their adherence to topical therapy and the possibility of switching to other strategies in the treatment process. Methods: An observational retrospective analysis was conducted based on administrative databases of two Italian local health units. All adult subjects who were diagnosed with psoriasis or who were newly prescribed for topical medication with at least one prescription between January 1, 2010, and December 31, 2014, were screened. Only patients who were “non-occasional users of topical drugs” (if they had at least two prescriptions of topical drugs in a time space of 2 years were considered for the first and second objectives in the analysis. The date of the first prescription of topical agents was identified as the index date (ID, which was then followed for all time available from ID (follow-up period. The adherence to therapy was assessed on the basis of cycles of treatment covered in the 6 months before the end of the follow-up period. The mean health care costs in patients who switched to disease-modifying antirheumatic drugs (DMARDs or biologics after the ID were evaluated. Results: A total of 17,860 patients with psoriasis who were newly prescribed for topical medication were identified. A total of 2,477 were identified as “non-occasional users of topical drugs”, of whom 70.2% had a prescription for a topical fixed combination regimen at ID. Around 19% adhered to their medication, whereas 6% switched to other options of psoriasis treatment. Multivariable logistic regression model shows that patients on fixed combination treatment were less likely to be non-adherent to treatment and less likely to switch to

Is topical haloperidol a useful glaucoma treatment?

OpenAIRE

Lavin, M. J.; Andrews, V.

1986-01-01

A randomised, double blind, single dose study of topical haloperidol, a dopamine receptor blocking drug, was performed on 20 healthy volunteers. After its administration a modest reduction in intraocular pressure was recorded over the six-hour study period, but the difference was not significant at the p less than 0.05 level. Although dopamine blocking agents are effective in reducing intraocular pressure in experimental animals, topical haloperidol appears unlikely to be clinically useful in...

Topical Melatonin for Treatment of Androgenetic Alopecia

OpenAIRE

Fischer, Tobias W; Tr?eb, Ralph M; H?nggi, Gabriella; Innocenti, Marcello; Elsner, Peter

2012-01-01

Background: In the search for alternative agents to oral finasteride and topical minoxidil for the treatment of androgenetic alopecia (AGA), melatonin, a potent antioxidant and growth modulator, was identified as a promising candidate based on in vitro and in vivo studies. Materials and Methods: One pharmacodynamic study on topical application of melatonin and four clinical pre-post studies were performed in patients with androgenetic alopecia or general hair loss and evaluated by standardise...

New guidelines for topical NSAIDs in the osteoarthritis treatment paradigm.

Science.gov (United States)

Altman, Roy D

2010-12-01

Osteoarthritis (OA), the most common form of arthritis, often affects hands, hips, and knees and involves an estimated 26.9 million US adults. Women have a higher prevalence of OA, and the risk of developing OA increases with age, obesity, and joint malalignment. OA typically presents with pain and reduced function. Therapeutic programs are often multimodal and must take into account pharmaceutical toxicities and patient comorbidities. For example, nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with cardiovascular, gastrointestinal, and renal adverse events. Topical NSAIDs offer efficacy with reduced systemic drug exposure. This is a review of current guideline recommendations regarding the use of topical NSAIDs in OA of the hand and knee. Articles were identified by PubMed search (January 1, 2000 to May 21, 2010). Several current guidelines for management of OA recommend topical NSAIDs, indicating them as a safe and effective treatment. One guideline recommends that topical NSAIDs be considered as first-line pharmacologic therapy. A US guideline for knee OA recommends topical NSAIDs in older patients and in patients with increased gastrointestinal risk. The consensus across US and European OA guidelines is that topical NSAIDs are a safe and effective treatment for OA. Because the research base on topical NSAIDs for OA is small, guidelines will continue to evolve.

The effects of oral and topical corticosteroid in rabbit corneas.

Science.gov (United States)

Araki-Sasaki, Kaoru; Katsuta, Osamu; Mano, Hidetoshi; Nagano, Takashi; Nakamura, Masatsugu

2016-09-05

To determine the most effective route of administration of corticosteroids in the treatment of ocular surface disease, by characterizing the difference between oral prednisolone and topical dexamethasone administration using an animal model. Pharmacokinetic analyses determined the corticosteroid concentrations in the normal ocular tissues of rabbits after oral or topical administration of corticosteroids using LC-MS/MS. In wound healing analyses, the area of the epithelial defect created by keratectomy using a 6-mm trephine was calculated with an image analyzer using an orally or topically steroid-administrated animal model. The average size of basal epithelial cells, the frequency of mitotic basal epithelial cells, the number of squamous cells, and the number of hypertrophic stromal fibroblasts were determined in the enucleated corneal tissues after wound closure. By slit lamp examination, no remarkable differences were observed between orally and topically administered groups. Pharmacokinetic analyses showed that the distribution of dexamethasone after topical administration was superior to that after oral administration in the cornea. In contrast, both concentrations of corticosteroid applied topically and orally were similar with regards to AUCs (area under the concentration-time curve) in the conjunctiva. Although the healing rate was slower in the topical group, all corneas were almost healed within 96 h in the wound healing analysis. According to the histological analyses of epithelial cells, the average basal cell size was larger, the frequency of mitotic basal cells was greater, and the number of squamous epithelial cell layers was lower in the topically administered group although all of these differences were with no statistical significance. However, the number of hypertrophic stromal fibroblasts in the topically administered group was significantly lower than that in the orally administered group. There are different distributions and effects between

A comparative study of the efficacy of topical negative pressure moist dressings and conventional moist dressings in chronic wounds

Directory of Open Access Journals (Sweden)

Tauro Leo

2007-01-01

Full Text Available Aim: To assess the efficacy of topical negative pressure moist wound dressing as compared to conventional moist wound dressings in improving the healing process in chronic wounds and to prove that negative pressure dressings can be used as a much better treatment option in the management of chronic wounds. Materials and Methods: This is a prospective comparative study of data from 112 patients with chronic wounds, of which 56 patients underwent topical negative pressure dressings (17 diabetic, 10 pressure sores, nine ischemic, two varicose, 10 post-infective raw areas and eight traumatic - six had bone exposed, two orthopaedic prosthesis exposed. The remaining 56 patients underwent conventional moist dressings (20 diabetic, two ischemic, 15 pressure sores, three varicose, eight post-infective raw areas and eight traumatic - five had bone exposed, three orthopaedic prosthesis exposed. The results were compared after 10 days. The variables compared were, rate of granulation tissue formation as a percentage of ulcer area covered, skin graft take up as the percentage of ulcer surface area and duration of hospital stay. The variables were compared using Unpaired Student′s t test. A " P" value < 0.05 was considered significant. Results: Out of 56 patients who underwent topical negative pressure dressings, six (10.71% were failures, due to failure in maintaining topical negative pressure due to defective sealing technique; these were included into the study group. After 10 days, the mean rate of granulation tissue formation was 71.43% of ulcer surface area. All these 56 cases underwent split-thickness skin grafting. The mean graft take-up was 79.29%. The mean hospital stay was 32.64 days. In the remaining 56 patients, the mean rate of granulation tissue formation was 52.85% of ulcer surface area. The mean graft take-up was only 60.45% of the total ulcer surface area. The mean hospital stay was 60.45 days. Conclusion: To conclude, topical negative

A globally complete map of supraglacial debris cover and a new toolkit for debris cover research

Science.gov (United States)

Herreid, Sam; Pellicciotti, Francesca

2017-04-01

A growing canon of literature is focused on resolving the processes and implications of debris cover on glaciers. However, this work is often confined to a handful of glaciers that were likely selected based on criteria optimizing their suitability to test a specific hypothesis or logistical ease. The role of debris cover in a glacier system is likely to not go overlooked in forthcoming research, yet the magnitude of this role at a global scale has not yet been fully described. Here, we present a map of debris cover for all glacierized regions on Earth including the Greenland Ice Sheet using 30 m Landsat data. This dataset will begin to open a wider context to the high quality, localized findings from the debris-covered glacier research community and help inform large-scale modeling efforts. A global map of debris cover also facilitates analysis attempting to isolate first order geomorphological and climate controls of supraglacial debris production. Furthering the objective of expanding the inclusion of debris cover in forthcoming research, we also present an under development suite of open-source, Python based tools. Requiring minimal and often freely available input data, we have automated the mapping of: i) debris cover, ii) ice cliffs, iii) debris cover evolution over the Landsat era and iv) glacier flow instabilities from altered debris structures. At the present time, debris extent is the only globally complete quantity but with the expanding repository of high quality global datasets and further tool development minimizing manual tasks and computational cost, we foresee all of these tools being applied globally in the near future.

Preferred Writing Topics of Urban and Rural Middle School Students

Science.gov (United States)

Shippen, Margaret E.; Houchins, David E.; Puckett, DaShaunda; Ramsey, Michelle

2007-01-01

This study compared the preferred writing topics of urban and rural middle school students. Eighth graders (n = 205) responded to a brief survey of preferred writing topics in the descriptive writing genres of real or imagined stories, reports, and opinions. While some preferred writing topics were divergent such as society, crime, and violence,…

The First World Congress on Tourette Syndrome and Tic Disorders: Controversies and Hot Topics in Etiology and Treatment

Science.gov (United States)

Mathews, Carol A.; Stern, Jeremy S.

2016-01-01

The first World Congress on Tourette Syndrome and Tic Disorders was held in London, June 2016 by the Tourette Association of America, Tourettes Action (UK), and the European Society for the Study of Tourette Syndrome. Presentations arising from large-scale collaborative projects were an important component of the scientific programme. This article focuses on areas raised in the hot topics session and two moderated debates, which covered emerging research in etiology and treatment. The hot topics ranged across genetics, arguably including the first confirmed Tourette Syndrome (TS) susceptibility gene NRXN1, neurocognition, and neurophysiology, including the possibility of a neurocognitive endophenotype for TS and the use of depth and cortical surface electrodes to investigate the neurophysiology of tics on the background of the evolving field of deep brain stimulation (DBS), to novel treatment approaches such as dental orthotics and an online behavioral intervention. The debates aired controversies in treatment; pharmacotherapy vs. behavioral treatment and the place of medical cannabinoids. These sessions demonstrate the vibrancy of a field that has considerably expanded in the last decade, the significant progress that has been made, and the direction that some of the most fruitful next phases of research will take. PMID:27375411

Oral Versus Topical Diclofenac Sodium in the Treatment of Osteoarthritis.

Science.gov (United States)

Tieppo Francio, Vinicius; Davani, Saeid; Towery, Chris; Brown, Tony L

2017-06-01

Osteoarthritis (OA) is one of the most common causes of joint pain in the United States and non-steroidal anti-inflammatories (NSAIDs), such as Diclofenac sodium, which is currently available in two main routes of administration; oral and topical distribution have been established as one of the standard treatments for OA. Generally, oral NSAIDs are well tolerated; however our narrative review suggests that the topical solution had a better tolerability property than oral Diclofenac sodium, especially due to side effects of gastrointestinal bleeding with the utilization of the oral format. In addition, the topical route may be considered a reasonable selection by clinicians for management of musculoskeletal pain in those patients with a history of potential risk and adverse side effects. Most studies reviewed comparing oral versus topical solution of Diclofenac sodium revealed comparable efficacy, with minimal side effects utilizing the topical route. The key point of this narrative review is to help clinicians that currently must decide between very inexpensive diclofenac oral presentations and expensive topical presentations especially in the elderly population and the pros and cons of such decision-making process.

Topicality and impact in social media: diverse messages, focused messengers.

Science.gov (United States)

Weng, Lilian; Menczer, Filippo

2015-01-01

We have a limited understanding of the factors that make people influential and topics popular in social media. Are users who comment on a variety of matters more likely to achieve high influence than those who stay focused? Do general subjects tend to be more popular than specific ones? Questions like these demand a way to detect the topics hidden behind messages associated with an individual or a keyword, and a gauge of similarity among these topics. Here we develop such an approach to identify clusters of similar hashtags in Twitter by detecting communities in the hashtag co-occurrence network. Then the topical diversity of a user's interests is quantified by the entropy of her hashtags across different topic clusters. A similar measure is applied to hashtags, based on co-occurring tags. We find that high topical diversity of early adopters or co-occurring tags implies high future popularity of hashtags. In contrast, low diversity helps an individual accumulate social influence. In short, diverse messages and focused messengers are more likely to gain impact.

On numerically pluricanonical cyclic coverings

International Nuclear Information System (INIS)

Kulikov, V S; Kharlamov, V M

2014-01-01

We investigate some properties of cyclic coverings f:Y→X (where X is a complex surface of general type) branched along smooth curves B⊂X that are numerically equivalent to a multiple of the canonical class of X. Our main results concern coverings of surfaces of general type with p g =0 and Miyaoka-Yau surfaces. In particular, such coverings provide new examples of multi-component moduli spaces of surfaces with given Chern numbers and new examples of surfaces that are not deformation equivalent to their complex conjugates

Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch

OpenAIRE

Lionberger, David

2010-01-01

David R Lionberger1, Michael J Brennan21Southwest Orthopedic Group, Houston, TX, USA; 2Department of Medicine, Bridgeport Hospital, Bridgeport, CT, USAAbstract: The objective of this article is to review published clinical data on diclofenac epolamine topical patch 1.3% (DETP) in the treatment of acute soft tissue injuries, such as strains, sprains, and contusions. Review of published literature on topical nonsteroidal anti-inflammatory drugs (NSAIDs), diclofenac, and DETP in patients with ac...

Topical medication instillation techniques for glaucoma.

Science.gov (United States)

Xu, Li; Wang, Xuemei; Wu, Meijing

2017-02-20

Glaucoma is a leading cause of irreversible blindness worldwide and the second most common cause of blindness after cataracts. The primary treatment for glaucoma aims to lower intraocular pressure (IOP) with the use of topical medicines. Topical medication instillation techniques, such as eyelid closure and nasolacrimal occlusion when instilling drops, have been proposed as potential methods to increase ocular absorption and decrease systemic absorption of the drops. To investigate the effectiveness of topical medication instillation techniques compared with usual care or another method of instillation of topical medication in the management of glaucoma or ocular hypertension. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 12), MEDLINE Ovid (1946 to 8 December 2016), Embase Ovid (1947 to 8 December 2016), PubMed (1948 to 8 December 2016), LILACS (Latin American and Caribbean Health Sciences Literature Database) (1982 to 8 December 2016), International Pharmaceutical Abstracts Database (1970 to 8 December 2016), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com) (last searched 13 May 2013), ClinicalTrials.gov (www.clinicaltrials.gov) (searched 8 December 2016) and the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en) (searched 8 December 2016). We did not use any date or language restrictions in the electronic searches for trials. We included randomized controlled trials which had compared any topical medication instillation technique with usual care or a different method of instillation of topical medication. Two review authors independently screened records from the searches for eligibility, assessed the risk of bias, and extracted data. We followed methods recommended by Cochrane. We identified two trials (122 eyes of 61 participants) that had evaluated a topical medication instillation technique. We

Electrocautery Superior to Topical Treatments for Precancerous Anal Lesions

Science.gov (United States)

... Professional Anal Cancer Treatment Anal Cancer Prevention Research Electrocautery Superior to Topical Treatments for Precancerous Anal Lesions ... randomized clinical trial conducted in Amsterdam suggest that electrocautery is better than topical imiquimod or fluorouracil at ...

Skin penetration and tissue permeation after topical administration of diclofenac.

Science.gov (United States)

Hagen, Martina; Baker, Mark

2017-09-01

Topical delivery of drugs is an alternative to oral administration, often with similar efficacy but potentially a more favorable tolerability profile. However, topical formulations need to be able to penetrate the skin and permeate to the target areas in quantities sufficient to exert a therapeutic effect. Many factors can affect this process, including the physicochemical properties of the drug, the formulation used, and the site and mode of application. It is believed that measurement of drug concentrations at the sites of action may be an indicator of their likely efficacy. This review addresses these issues, with reference to topically administered diclofenac in osteoarthritis. Articles relevant to this review were identified after a systematic search of Medline and Embase, using the key words "diclofenac", "topical administration" and "osteoarthritis" in the search strategy. The sparse data available indicate that topical diclofenac can penetrate and permeate to deeper tissues, with a lower plasma to tissue ratio than oral diclofenac. The tissue diclofenac levels after topical delivery are sustained over time (at least several hours). However, there is not enough data to establish how diclofenac levels in the joint compare with IC 50 levels (50% of the maximum inhibition of prostaglandin synthesis) established following oral administration. After topical application, diclofenac can penetrate the skin and permeate to deeper tissues, where it reaches a concentration that appears to be sufficient to exert a therapeutic effect. More robust methods are required for in vivo characterization to better estimate the clinical efficacy of topically applied drugs.

Laser-assisted delivery of topical methotrexate - in vitro investigations

DEFF Research Database (Denmark)

Taudorf, Elisabeth Hjardem

2016-01-01

of the correlation between laser parameters and tissue effects was used to deliver methotrexate (MTX) topically through microscopic ablation zones (MAZs) of precise dimensions. MTX is a well-known chemotherapeutic and anti-inflammatory drug that may cause systemic adverse effects, and topical delivery is thus......Ablative fractional lasers (AFXL) are increasingly used to treat dermatological disorders and to facilitate laser-assisted topical drug delivery. In this thesis, laser-tissue interactions generated by stacked pulses with a miniaturized low-power 2,940 nm AFXL were characterized (study I). Knowledge...... zones of varying thickness. The ratio of skin deposition versus transdermal permeation was constant, regardless of MAZ depth. Impact of transport kinetics on AFXL-assisted topical MTX delivery: MTX accumulated rapidly in AFXL-processed skin. MTX was detectable in mid-dermis after 15 min. and saturated...

EDITORIAL: International Workshop on Current Topics in Monte Carlo Treatment Planning

Science.gov (United States)

Verhaegen, Frank; Seuntjens, Jan

2005-03-01

The use of Monte Carlo particle transport simulations in radiotherapy was pioneered in the early nineteen-seventies, but it was not until the eighties that they gained recognition as an essential research tool for radiation dosimetry, health physics and later on for radiation therapy treatment planning. Since the mid-nineties, there has been a boom in the number of workers using MC techniques in radiotherapy, and the quantity of papers published on the subject. Research and applications of MC techniques in radiotherapy span a very wide range from fundamental studies of cross sections and development of particle transport algorithms, to clinical evaluation of treatment plans for a variety of radiotherapy modalities. The International Workshop on Current Topics in Monte Carlo Treatment Planning took place at Montreal General Hospital, which is part of McGill University, halfway up Mount Royal on Montreal Island. It was held from 3-5 May, 2004, right after the freezing winter has lost its grip on Canada. About 120 workers attended the Workshop, representing 18 countries. Most of the pioneers in the field were present but also a large group of young scientists. In a very full programme, 41 long papers were presented (of which 12 were invited) and 20 posters were on display during the whole meeting. The topics covered included the latest developments in MC algorithms, statistical issues, source modelling and MC treatment planning for photon, electron and proton treatments. The final day was entirely devoted to clinical implementation issues. Monte Carlo radiotherapy treatment planning has only now made a slow entrée in the clinical environment, taking considerably longer than envisaged ten years ago. Of the twenty-five papers in this dedicated special issue, about a quarter deal with this topic, with probably many more studies to follow in the near future. If anything, we hope the Workshop served as an accelerator for more clinical evaluation of MC applications. The

Armenian media coverage of science topics

Science.gov (United States)

Mkhitaryan, Marie

2016-12-01

The article discusses features and issues of Armenian media coverage on scientific topics and provides recommendations on how to promote scientific topics in media. The media is more interested in social or public reaction rather than in scientific information itself. Medical science has a large share of the global media coverage. It is followed by articles about environment, space, technology, physics and other areas. Armenian media mainly tends to focus on a scientific topic if at first sight it contains something revolutionary. Media primarily reviews whether that scientific study can affect the Armenian economy and only then decides to refer to it. Unfortunately, nowadays the perception of science is a little distorted in media. We can often see headlines of news where is mentioned that the scientist has made "an invention". Nowadays it is hard to see the border between a scientist and an inventor. In fact, the technological term "invention" attracts the media by making illusionary sensation and ensuring large audience. The report also addresses the "Gitamard" ("A science-man") special project started in 2016 in Mediamax that tells about scientists and their motivations.

How to Prevent Heart Disease: MedlinePlus Health Topic

Science.gov (United States)

... and your heart (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get How to Prevent ... your heart Stress and your heart Related Health Topics Blood Thinners Cholesterol Heart Diseases Heart Health Tests ...

Tetanus, Diphtheria, and Pertussis Vaccines: MedlinePlus Health Topic

Science.gov (United States)

... Know (Centers for Disease Control and Prevention) - PDF Topic Image MedlinePlus Email Updates Get Tetanus, Diphtheria, and ... updates by email What's this? GO Related Health Topics Childhood Immunization Diphtheria Immunization Tetanus Whooping Cough National ...

Graph-based Techniques for Topic Classification of Tweets in Spanish

Directory of Open Access Journals (Sweden)

Hector Cordobés

2014-03-01

Full Text Available Topic classification of texts is one of the most interesting challenges in Natural Language Processing (NLP. Topic classifiers commonly use a bag-of-words approach, in which the classifier uses (and is trained with selected terms from the input texts. In this work we present techniques based on graph similarity to classify short texts by topic. In our classifier we build graphs from the input texts, and then use properties of these graphs to classify them. We have tested the resulting algorithm by classifying Twitter messages in Spanish among a predefined set of topics, achieving more than 70% accuracy.

Topics in computational linear optimization

DEFF Research Database (Denmark)

Hultberg, Tim Helge

2000-01-01

Linear optimization has been an active area of research ever since the pioneering work of G. Dantzig more than 50 years ago. This research has produced a long sequence of practical as well as theoretical improvements of the solution techniques avilable for solving linear optimization problems...... of high quality solvers and the use of algebraic modelling systems to handle the communication between the modeller and the solver. This dissertation features four topics in computational linear optimization: A) automatic reformulation of mixed 0/1 linear programs, B) direct solution of sparse unsymmetric...... systems of linear equations, C) reduction of linear programs and D) integration of algebraic modelling of linear optimization problems in C++. Each of these topics is treated in a separate paper included in this dissertation. The efficiency of solving mixed 0-1 linear programs by linear programming based...

Measuring and analyzing urban tree cover

Science.gov (United States)

David J. Nowak; Rowan A. Rowntree; E. Gregory McPherson; Susan M. Sisinni; Esther R. Kirkmann; Jack C. Stevens

1996-01-01

Measurement of city tree cover can aid in urban vegetation planning, management, and research by revealing characteristics of vegetation across a city. Urban tree cover in the United States ranges from 0.4% in Lancaster, California, to 55% in Baton Rouge, Louisiana. Two important factors that affect the amount of urban tree cover are the natural environment and land...

Two topics in quantum chromodynamics

International Nuclear Information System (INIS)

Bjorken, J.D.

1989-12-01

The two topics are (1) estimates of perturbation theory coefficients for R(e + e - → hadrons), and (2) the virtual-photon structure function, with emphasis on the analytic behavior in its squared mass. 20 refs., 4 figs., 2 tabs

Vaccine Hesitancy in Discussion Forums: Computer-Assisted Argument Mining with Topic Models.

Science.gov (United States)

Skeppstedt, Maria; Kerren, Andreas; Stede, Manfred

2018-01-01

Arguments used when vaccination is debated on Internet discussion forums might give us valuable insights into reasons behind vaccine hesitancy. In this study, we applied automatic topic modelling on a collection of 943 discussion posts in which vaccine was debated, and six distinct discussion topics were detected by the algorithm. When manually coding the posts ranked as most typical for these six topics, a set of semantically coherent arguments were identified for each extracted topic. This indicates that topic modelling is a useful method for automatically identifying vaccine-related discussion topics and for identifying debate posts where these topics are discussed. This functionality could facilitate manual coding of salient arguments, and thereby form an important component in a system for computer-assisted coding of vaccine-related discussions.

Quantization of noncompact coverings and its physical applications

Science.gov (United States)

Ivankov, Petr

2018-02-01

A rigorous algebraic definition of noncommutative coverings is developed. In the case of commutative algebras this definition is equivalent to the classical definition of topological coverings of locally compact spaces. The theory has following nontrivial applications: • Coverings of continuous trace algebras, • Coverings of noncommutative tori, • Coverings of the quantum SU(2) group, • Coverings of foliations, • Coverings of isospectral deformations of Spin - manifolds. The theory supplies the rigorous definition of noncommutative Wilson lines.

Characterizing interdisciplinarity of researchers and research topics using web search engines.

Science.gov (United States)

Sayama, Hiroki; Akaishi, Jin

2012-01-01

Researchers' networks have been subject to active modeling and analysis. Earlier literature mostly focused on citation or co-authorship networks reconstructed from annotated scientific publication databases, which have several limitations. Recently, general-purpose web search engines have also been utilized to collect information about social networks. Here we reconstructed, using web search engines, a network representing the relatedness of researchers to their peers as well as to various research topics. Relatedness between researchers and research topics was characterized by visibility boost-increase of a researcher's visibility by focusing on a particular topic. It was observed that researchers who had high visibility boosts by the same research topic tended to be close to each other in their network. We calculated correlations between visibility boosts by research topics and researchers' interdisciplinarity at the individual level (diversity of topics related to the researcher) and at the social level (his/her centrality in the researchers' network). We found that visibility boosts by certain research topics were positively correlated with researchers' individual-level interdisciplinarity despite their negative correlations with the general popularity of researchers. It was also found that visibility boosts by network-related topics had positive correlations with researchers' social-level interdisciplinarity. Research topics' correlations with researchers' individual- and social-level interdisciplinarities were found to be nearly independent from each other. These findings suggest that the notion of "interdisciplinarity" of a researcher should be understood as a multi-dimensional concept that should be evaluated using multiple assessment means.

The Effect of Testosterone Topical Solution in Hypogonadal Men With Suboptimal Response to a Topical Testosterone Gel.

Science.gov (United States)

Burns, Patrick R; Kim, Edward D; Ruff, Dustin D; Seftel, Allen D

2018-05-01

This study evaluated the effect of axillary administration of a 2% testosterone solution (Axiron ® ) in hypogonadal (HGN) men who had had a suboptimal response to treatment with a commercially available topical testosterone gel. HGN men averaging 57 years old, with a mean body mass index of 31.9 kg/m 2 and median baseline testosterone level (T-level) of 185.2 ng/dL, who had failed to reach normal T-levels with a topical testosterone gel (Androgel 1.62%, Androgel, Testim, or Fortesta) were treated with a 2% testosterone solution until T-levels reached a normal range (from ≥300 to ≤1,050 ng/dL) or for up to 9 weeks. Outcomes included the cumulative percentage of men with a serum T-level in the normal range during treatment with Axiron and improvement in symptoms of low energy level and low sexual drive. During the study, 95% of HGN men (72/78) attained a T-level in the normal range. The median T-level at endpoint was 495.7 ng/dL, a threefold increase over baseline, p levels within the first 2 weeks of treatment. In a post hoc analysis, all subjects with baseline body mass indexes >35 kg/m 2 ( n = 19) achieved T-levels in the normal range. Prior to treatment, over 61% of subjects (48/78) reported impairment in either energy level or sexual drive. After treatment (or testosterone normalization), energy level improved in 75% of subjects and sexual drive improved in 70%. Topical 2% testosterone solution is a safe and effective treatment for HGN men who have had a suboptimal response to previous treatment with topical testosterone gels.

Topical use of dexpanthenol: a 70th anniversary article.

Science.gov (United States)

Proksch, Ehrhardt; de Bony, Raymond; Trapp, Sonja; Boudon, Stéphanie

2017-12-01

Approximately 70 years ago, the first topical dexpanthenol-containing formulation (Bepanthen™ Ointment) has been developed. Nowadays, various topical dexpanthenol preparations exist, tailored according to individual requirements. Topical dexpanthenol has emerged as frequently used formulation in the field of dermatology and skin care. Various studies confirmed dexpanthenol's moisturizing and skin barrier enhancing potential. It prevents skin irritation, stimulates skin regeneration and promotes wound healing. Two main directions in the use of topical dexpanthenol-containing formulations have therefore been pursued: as skin moisturizer/skin barrier restorer and as facilitator of wound healing. This 70th anniversary paper reviews studies with topical dexpanthenol in skin conditions where it is most frequently used. Although discovered decades ago, the exact mechanisms of action of dexpanthenol have not been fully elucidated yet. With the adoption of new technologies, new light has been shed on dexpanthenol's mode of action at the molecular level. It appears that dexpanthenol increases the mobility of stratum corneum molecular components which are important for barrier function and modulates the expression of genes important for wound healing. This review will update readers on recent advances in this field.

Women in sustainable agriculture and food biotechnology key advances and perspectives on emerging topics

CERN Document Server

2017-01-01

This volume describes the contributions made by women scientists to the field of agricultural biotechnology, the most quickly adopted agricultural practice ever adopted. It features the perspectives of women educators, researchers and key stakeholders towards the development, implementation and acceptance of this modern technology. It describes the multiplying contemporary challenges in the field, how women are overcoming technological barriers, and their thoughts on what the future may hold. As sustainable agricultural practices increasingly represent a key option in the drive towards building a greener global community, the scientific, technological and implementation issues covered in this book are vital information for anyone working in environmental engineering. Provides a broad analysis of the science of agriculture, focusing on the contributions of women to the field, from basic research to applied technology Offers insights into hot topics in the field across the life cycle, from genetic engineering t...

Retrospective Evaluation of Topical Bimatoprost and Iris Pigmentation Change.

Science.gov (United States)

Zaleski-Larsen, Lisa A; Ruth, Nadine H; Fabi, Sabrina G

2017-12-01

Topical bimatoprost is a topical prostaglandin analog originally used to treat glaucoma and more recently used to cosmetically induce hypertrichosis of the eyelashes. Iris pigmentation change has been noted in the treatment of glaucoma but has not been assessed with the cosmetic periorbital application of bimatoprost. To evaluate for iris pigmentation change with the long-term cosmetic use of topical bimatoprost. A retrospective chart review in a cosmetic dermatology practice of women (N = 50) who consistently purchased topical bimatoprost over an average of 4.59 years was compared with that of age-matched non-bimatoprost patients (N = 50). A blinded evaluator assessed each patient for iris pigmentary change. No iris pigmentation change was noted with the cutaneous application of bimatoprost. The cutaneous application of bimatoprost appears to be safe with minimal risk for iris pigmentation change.

Increased Topical Generic Prices by Manufacturers: An Isolated Trend or Worrisome Future?

Science.gov (United States)

Bhatt, Mehul D; Bhatt, Birju D; Dorrian, James T; McLellan, Beth N

2018-03-12

There is limited data regarding generic medication prices. Recent studies have shown price changes at the retail level, but much is not known about the pharmaceutical supply chain or price changes at the manufacturer level. We sought to examine the extent of price changes for topical generic medications. A comprehensive review of average wholesale prices (AWP) and manufacturers of topical generics and available corresponding branded medications was conducted for 2005 and 2016. A total of 51 topical chemical entities were examined. Between 2005 and 2016, the AWP of topical generics increased by 273% and the AWP of topical branded increased by 379%. The topical generic with the most price change increased by 2529%. Eight of the top twenty topical generics with the highest increase in AWP also had an increase in the number of manufacturers. These findings are not generalizable to medications used in other areas of medicine CONCLUSIONS: Topical generic prices are rapidly increasing at the manufacturer level. Copyright © 2018. Published by Elsevier Inc.

Percent Forest Cover

Data.gov (United States)

U.S. Environmental Protection Agency — Forests provide economic and ecological value. High percentages of forest cover (FORPCT) generally indicate healthier ecosystems and cleaner surface water. More...

Dressings and topical agents for preventing pressure ulcers.

Science.gov (United States)

Moore, Zena E H; Webster, Joan

2013-08-18

Pressure ulcers, which are localised injury to the skin, or underlying tissue or both, occur when people are unable to reposition themselves to relieve pressure on bony prominences. Pressure ulcers are often difficult to heal, painful and impact negatively on the individual's quality of life. The cost implications of pressure ulcer treatment are considerable, compounding the challenges in providing cost effective, efficient health services. Efforts to prevent the development of pressure ulcers have focused on nutritional support, pressure redistributing devices, turning regimes and the application of various topical agents and dressings designed to maintain healthy skin, relieve pressure and prevent shearing forces. Although products aimed at preventing pressure ulcers are widely used, it remains unclear which, if any, of these approaches are effective in preventing the development of pressure ulcers. To evaluate the effects of dressings and topical agents on the prevention of pressure ulcers, in people of any age without existing pressure ulcers, but considered to be at risk of developing a pressure ulcer, in any healthcare setting. In February 2013 we searched the following electronic databases to identify reports of relevant randomised clinical trials (RCTs): the Cochrane Wounds Group Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library); Database of Abstracts of Reviews of Effects (The Cochrane Library); Ovid MEDLINE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations); Ovid EMBASE; and EBSCO CINAHL. We included RCTs evaluating the use of dressings, topical agents, or topical agents with dressings, compared with a different dressing, topical agent, or combined topical agent and dressing, or no intervention or standard care, with the aim of preventing the development of a pressure ulcer. We assessed trials for their appropriateness for inclusion and for their risk of bias. This was done by two review

Land cover fire proneness in Europe

Directory of Open Access Journals (Sweden)

Mario Gonzalez Pereira

2014-12-01

Full Text Available Aim of study: This study aims to identify and characterize the spatial and temporal evolution of the types of vegetation that are most affected by forest fires in Europe. The characterization of the fuels is an important issue of the fire regime in each specific ecosystem while, on the other hand, fire is an important disturbance for global vegetation dynamics.Area of study: Southern European countries: Portugal, Spain, France, Italy and Greece.Material and Methods: Corine Land Cover maps for 2000 and 2006 (CLC2000, CLC2006 and burned area (BA perimeters, from 2000 to 2013 in Europe are combined to access the spatial and temporal evolution of the types of vegetation that are most affected by wild fires using descriptive statistics and Geographical Information System (GIS techniques.Main results: The spatial and temporal distribution of BA perimeters, vegetation and burnt vegetation by wild fires was performed and different statistics were obtained for Mediterranean and entire Europe, confirming the usefulness of the proposed land cover system. A fire proneness index is proposed to assess the fire selectivity of land cover classes. The index allowed to quantify and to compare the propensity of vegetation classes and countries to fire.Research highlights: The usefulness and efficiency of the land cover classification scheme and fire proneness index. The differences between northern Europe and southern Europe and among the Mediterranean region in what concerns to vegetation cover, fire incidence, area burnt in land cover classes and fire proneness between classes for the different countries.Keywords: Fire proneness; Mixed forests; Land cover/land use; Fire regime; Europe; GIS; Corine land cover. 

Diabetes HealthSense: Resources for Living Well

Medline Plus

Full Text Available ... and Kidney Disease 12 Diabetes is the leading cause of kidney disease. People living with diabetes offer tips on managing your diabetes and preventing kidney disease. Player Controls Use these controls to control the play back of videos. ... with Stress and Emotions AADE7 Self-Care Behaviors Handouts - Healthy Coping These handouts provide facts, tips, ...

Scenarios of land cover in China

Science.gov (United States)

Yue, Tian Xiang; Fan, Ze Meng; Liu, Ji Yuan

2007-02-01

A method for surface modeling of land cover change (SMLC) is developed on the basis of establishing transition probability matrixes between land cover types and HLZ types. SMLC is used to simulate land cover scenarios of China for the years 2039, 2069 and 2099, for which HLZ scenarios are first simulated in terms of HadCM3 climatic scenarios that are downscaled in zonal model of spatial climate change in China. This paper also analyzes spatial distribution of land cover types, area change and mean center shift of each land cover type, ecotope diversity, and patch connectivity under the land cover scenarios. The results show that cultivated land would decrease and woodland would expand greatly with climatic change, which coincides with consequences expected by implementation of Grain-for-Green policy. Nival area would shrink, and desertification area would expand at a comparatively slow rate in future 100 years. Climate change would generally cause less ecotope diversity and more patch connectivity. Ecosystems in China would have a pattern of beneficial cycle after efficient ecological conservation and restoration. However, if human activities would exceed regulation capacity of ecosystems themselves, the ecosystems in China might deteriorate more seriously.

Topical minoxidil in the treatment of alopecia areata.

Science.gov (United States)

Fenton, D A; Wilkinson, J D

1983-01-01

A modified double blind crossover study was performed to assess the effect of 1% topical minoxidil as compared with placebo in 30 patients with alopecia areata and alopecia totalis. The active preparation produced a highly significant incidence of hair regrowth. A cosmetically acceptable response was noted in 16 patients. No side effects were seen. The study confirmed that topical minoxidil will induce new hair growth in alopecia areata but that it is less likely to do so in more severe and extensive disease. Furthermore, patients with alopecia universalis and totalis may not respond at all. Nevertheless, as compared with other drugs minoxidil applied topically is relatively non-toxic, is easy to use, and has no systemic or local side effects. Images p1016-a PMID:6412929

CLC2000 land cover database of the Netherlands; monitoring land cover changes between 1986 and 2000

OpenAIRE

Hazeu, G.W.

2003-01-01

The 1986 CORINE land cover database of the Netherlands was revised and updated on basis of Landsat satellite images and ancillary data. Interpretation of satellite images from 1986 and 2000 resulted in the CLC2000, CLC1986rev and CLCchange databases. A standard European legend and production methodology was applied. Thirty land cover classes were discerned. Most extended land cover types were pastures (231), arable land (211) and complex cultivation patterns (242). Between 1986 and 2000 aroun...

Carbon Assessment of Hawaii Land Cover Map (CAH_LandCover)

Data.gov (United States)

Department of the Interior — While there have been many maps produced that depict vegetation for the state of Hawai‘i only a few of these display land cover for all of the main Hawaiian Islands,...

Selected topics in grand unification

International Nuclear Information System (INIS)

Seckel, D.

1983-01-01

This dissertation is a collection of four pieces of research dealing with grand unification. The topics are neutron oscillation, CP violation, magnetic monopole abundance and distribution in neutron stars, and a proposal for an inflationary cosmology driven by stress-energy in domain walls

An effective coherence measure to determine topical consistency in user-generated content

NARCIS (Netherlands)

He, J.; Weerkamp, W.; Larson, M.; de Rijke, M.

2009-01-01

When searching for blogs on a specific topic, information seekers prefer blogs that place a central focus on that topic over blogs whose mention of the topic is diffuse or incidental. In order to present users with better blog feed search results, we developed a measure of topical consistency that

Topical antifungal agents: an update.

Science.gov (United States)

Diehl, K B

1996-10-01

So many topical antifungal agents have been introduced that it has become very difficult to select the proper agent for a given infection. Nonspecific agents have been available for many years, and they are still effective in many situations. These agents include Whitfield's ointment, Castellani paint, gentian violet, potassium permanganate, undecylenic acid and selenium sulfide. Specific antifungal agents include, among others, the polyenes (nystatin, amphotericin B), the imidazoles (metronidazole, clotrimazole) and the allylamines (terbinafine, naftifine). Although the choice of an antifungal agent should be based on an accurate diagnosis, many clinicians believe that topical miconazole is a relatively effective agent for the treatment of most mycotic infections. Terbinafine and other newer drugs have primary fungicidal effects. Compared with older antifungal agents, these newer drugs can be used in lower concentrations and shorter therapeutic courses. Studies are needed to evaluate the clinical efficacies and cost advantages of both newer and traditional agents.

Topical report review status, July 15, 1983. Vol. 7, No. 1

International Nuclear Information System (INIS)

1983-08-01

A Topical Report Review Status is scheduled to be published semi-annually. The primary purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the Nuclear Regulatory Commission (NRC) staff review has been completed and, to the extent practicable, to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility

The role of preventive topical antibiotic treatment prior to intravitreal injection

Directory of Open Access Journals (Sweden)

Elena Vladimirovna Ageeva

2015-06-01

Full Text Available Treatment of wet age-related macular degeneration (AMD requires frequent intravitreal injections of anti-VEGF agents, sometimes on monthly basis during a long period of time. Endophthalmitis is a rare but extremely severe complication of intravitreal injections. As it has been proven before, the flora from the conjunctival surface is the main source for endophthalmitis. Using Povidone-iodine solution (Betadine10 % Povidone-iodine, EGIS PHARMACEUTICALS is the only way to prevent endophthalmitis. The efficacy of it was proven by numerous studies. No evidence exists that topical antibiotiotics prior and after injections could be effective for prevention of endophthalmitis. Purpose: To study the advisability of topical antibiotic application before intravitreal injection. Materials and methods: Under investigation, there were 25 eyes of 25 patients with wet AMD treated by anti-VEGF intravitreal injections. All patients used topical antibiotics 3 days before injection. Conjunctival culture from injection eye was collected three times: before topical antibiotic use; after topical antibiotic use, and after Betadine 5 % application. Results: The rates of Staphylococcus epidermidis before and after topical antibiotic use were approximately equal. However there was no Staphylococcus epidermidis found after Betadine 5 % application. Conclusion: Our study showed the effectiveness of Betadine 5 % solution in conjunctival flora reduction. Use of topical antibiotics 3 days prior intravitreal injections is not effective. Key words: age-related macular degeneration; endophthalmitis; intravitreal injection; topical antibiotics; endophthalmitis prevention.

An overview of topical treatment for atopic eczema | Motswaledi ...

African Journals Online (AJOL)

... on the elbows and knees in younger children, and the cubital and popliteal fossae in older children and adults. Treatment modalities include emollients, topical corticosteroids, calcineurin inhibitors, phototherapy and immunosuppressive therapy. This article provides a brief overview of topical treatments for atopic eczema.

Toxic keratopathy due to abuse of topical anesthetic drugs.

Science.gov (United States)

Yeniad, Baris; Canturk, Serife; Esin Ozdemir, Fatma; Alparslan, Nilufer; Akarcay, Koray

2010-06-01

To describe 8 cases of toxic keratopathy due to abuse of topical anesthetic drugs. Clinical findings from patients with toxic keratopathy were investigated retrospectively. Two patients had toxic keratopathy bilaterally. Five of 8 patients had an ocular history of a corneal foreign body, 1 had basal membrane dystrophy, 1 had ultraviolet radiation, and 1 had chemical burn. All patients had undergone psychiatric consultation. Four patients had anxiety disorder and 1 had bipolar disease. Clinical signs were improved in all patients with discontinuation of topical anesthetic drug use along with adjunctive psychiatric treatment. Penetrating keratoplasty was performed in 2 patients. Toxic keratopathy due to topical anesthetic abuse is a curable disease. Early diagnosis and prevention of topical anesthetic drug use are the most important steps in the treatment of this condition. As these patients commonly exhibit psychiatric disorders, adjunctive psychiatric treatment may help to break the chemical addiction.

Topic shift impairs pronoun resolution during sentence comprehension: Evidence from event-related potentials.

Science.gov (United States)

Xu, Xiaodong; Zhou, Xiaolin

2016-02-01