Clad Treatment in KARMA Code and Library

Energy Technology Data Exchange (ETDEWEB)

Lee, Jeong-yeup; Lee, Hae-chan; Woo, Hae-seuk [KEPCO Nuclear Fuel Co., Daejeon (Korea, Republic of)

2016-05-15

Zirconium is the main components in clad materials. The subgroup parameters of zirconium were generated with effective cross section which obtained by using flux distribution in clad region. It decreases absorption reaction rate differences with reference MCNP results. Use of composite nuclide is acceptable to increase efficiency but should be limited to specific target composition. Therefore, the use of the composite nuclide of Zircaloy-2 should be limited when HANA clad material is used for clad. Either using explicit components or generating composite nuclide for HANA is suggested. This paper investigates the clad analysis model for KARMA whether current method is applicable to HANA clad material.

Alignment of high-throughput sequencing data inside in-memory databases.

Science.gov (United States)

Firnkorn, Daniel; Knaup-Gregori, Petra; Lorenzo Bermejo, Justo; Ganzinger, Matthias

2014-01-01

In times of high-throughput DNA sequencing techniques, performance-capable analysis of DNA sequences is of high importance. Computer supported DNA analysis is still an intensive time-consuming task. In this paper we explore the potential of a new In-Memory database technology by using SAP's High Performance Analytic Appliance (HANA). We focus on read alignment as one of the first steps in DNA sequence analysis. In particular, we examined the widely used Burrows-Wheeler Aligner (BWA) and implemented stored procedures in both, HANA and the free database system MySQL, to compare execution time and memory management. To ensure that the results are comparable, MySQL has been running in memory as well, utilizing its integrated memory engine for database table creation. We implemented stored procedures, containing exact and inexact searching of DNA reads within the reference genome GRCh37. Due to technical restrictions in SAP HANA concerning recursion, the inexact matching problem could not be implemented on this platform. Hence, performance analysis between HANA and MySQL was made by comparing the execution time of the exact search procedures. Here, HANA was approximately 27 times faster than MySQL which means, that there is a high potential within the new In-Memory concepts, leading to further developments of DNA analysis procedures in the future.

ERP Effort Estimation Based on Expert Judgments

NARCIS (Netherlands)

Erasmus, I.P.; Daneva, Maia; Demirors, O.; Abran, A.

2013-01-01

A new technology shift brings to the ERP domain a change in the industry and a new platform build on in-memory optimized databases, introduced and known as SAP HANA [1]. This technology shift in the ERP domain led to SAP's ERP on HANA, the solution where the ERP suite is offered on the same platform

Phase I Archaeological Investigation Cultural Resources Survey, Hawaii Geothermal Project, Makawao and Hana Districts, South Shore of Maui, Hawaii (DRAFT )

Energy Technology Data Exchange (ETDEWEB)

Erkelens, Conrad

1994-03-01

This report details the archaeological investigation of a 200 foot wide sample corridor extending approximately 9 miles along the southern portion of Maui within the present districts of Hana and Makawao. A total of 51 archaeological sites encompassing 233 surface features were documented. A GPS receiver was used to accurately and precisely plot locations for each of the documented sites. Analysis of the locational information suggests that archaeological sites are abundant throughout the region and only become scarce where vegetation has been bulldozed for ranching activities. At the sea-land transition points for the underwater transmission cable, both Ahihi Bay and Huakini Bay are subjected to seasonal erosion and redeposition of their boulder shorelines. The corridor at the Ahihi Bay transition point runs through the Moanakala Village Complex which is an archaeological site on the State Register of Historic Places within a State Natural Area Reserve. Numerous other potentially significant archaeological sites lie within the project corridor. It is likely that rerouting of the corridor in an attempt to avoid known sites would result in other undocumented sites located outside the sample corridor being impacted. Given the distribution of archaeological sites, there is no alternative route that can be suggested that is likely to avoid encountering sites. A total of twelve charcoal samples were obtained for potential taxon identification and radiocarbon analysis. Four of these samples were subsequently submitted for dating and species identification. Bird bone from various locations within a lava tube were collected for identification. Sediment samples for subsequent pollen analysis were obtained from within two lava tubes. With these three sources of information it is hoped that paleoenvironmental data can be recovered that will enable a better understanding of the setting for Hawaiian habitation of the area. A small test unit was excavated at one habitation site

Removal of Hg(II) from aqueous solution using sodium humate as heavy metal capturing agent.

Science.gov (United States)

Wang, Shixiang; Liu, Yong; Fan, Qin; Zhou, Anlan; Fan, Lu; Mu, Yulan

2016-12-01

An environmental friendly and economic natural biopolymer-sodium humate (HA-Na) was used to capture Hg(II) from aqueous solutions, and the trapped Hg(II) (HA-Na-Hg) was then removed by aluminium coagulation. The best Hg(II) capturing performance (90.60%) was observed under the following conditions: initial pH of 7.0, coagulation pH of 6.0, HA-Na dosage of 5.0 g L -1 , Al 2 (SO 4 ) 3 .18H 2 O dosage of 4.0 g L -1 , initial Hg(II) concentration of 50 mg L -1 and capturing time of 30 min. The HA-Na compositions with the molecular weight beyond 70 kDa showed the most intense affinity toward Hg(II). The results showed that the reaction equilibrium was achieved within 10 min (pH 7.0), and could be well fitted by the pseudo-second-order kinetics model. The capturing process could be well described by the Langmuir isotherm model and the maximum capturing capacity of Hg(II) was high up to 9.80 mg g -1 at 298 K (pH 7.0). The Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) analysis showed that the redox reaction between Hg(II) and HA-Na and the coordination reaction of carboxyl and hydroxy groups of HA-Na with Hg(II) were responsible for Hg(II) removal. The successive regeneration experiment showed that the capturing efficiency of humates for Hg(II) was maintained at about 51% after five capture-regeneration recycles.

Real-Time Physiological and Psycho-Physiological Status Monitoring (Suivi en Temps reel de l’Etat Physiologique et Psycho-Physiologique)

Science.gov (United States)

2010-07-01

Physiol, 98:591-597. [35] Maggiorini, M., Melot, C., Pierre, S., Pfeiffer, F., Greve, I., Sartori, C., Lepori, M., Hauser , M., Scherrer, U. and Naeije, R...A PHYSIOLOGICAL MONITORING SYSTEM (DESCRIPTION OF THE WORK IN THE CZECH REPUBLIC) Pavel Smrcka, Karel Hana, Jan Kaspar , Radek Fiala Clever...variability analysis in general medicine. Indian Pacing Electrophysiol. Journal, 2003; 3(1):34. [6] Hana, K., Fiala, R., Kaspar , J., Smrcka, P. and Brada

The Clinician in Leadership. Perceptions of Style. Perspectives from Rural Primary Medicine in Norway.

OpenAIRE

Hana, Jan

2014-01-01

The papers of this thesis are not available in Munin I: Hana, J. & Rudebeck, C. A.: 'Leadership in rural medicine: The organization on thin ice?', Scandinavian Journal of Primary Health Care, 2011; 29: 122–128. Available at http://dx.doi.org/10.3109/02813432.2011.577148 II: Hana, J. & Kirkhaug, R.: ‘Physicians’ leadership styles in rural primary medical care: how are they perceived by staff?’, Scandinavian Journal of Primary Health Care, 2014; 32: 4–10. Available at http://dx.doi.org/10.3109/...

Funkčnost komunikačních systémů u dětí a žáků s kongenitální hluchslepotou

OpenAIRE

Pavlíčková, Hana

2011-01-01

Rigorózní práce Hana Pavlíčková ABSTRACT The functionality of the communication systems for congenital delf-blind children and pupils Hana Pavlíčková, Mgr. Abstract: The topic of this thesis is the communication skills of children with congenital deafblind toward their parents and the next of kin in the pragmatical level of communication. There are two parts of this thesis - theoretical part and empirical part. The first one contains some definitions of the terms communication, deafblind and ...

Components of effective randomized controlled trials of hydrotherapy programs for fibromyalgia syndrome: A systematic review

OpenAIRE

Perraton, Luke; Machotka, Zuzana; Kumar, Saravana

2009-01-01

Luke Perraton, Zuzana Machotka, Saravana KumarInternational Centre for Allied Health Evidence, University of South Australia, Adelaide, South Australia, AustraliaAim: Previous systematic reviews have found hydrotherapy to be an effective management strategy for fibromyalgia syndrome (FMS). The aim of this systematic review was to summarize the components of hydrotherapy programs used in randomized controlled trials.Method: A systematic review of randomized controlled trials was conducted. Onl...

Zuzana Husárová: lyrika lidská i technologická

Czech Academy of Sciences Publication Activity Database

Piorecký, Karel

2016-01-01

Roč. 8, č. 38 (2016), s. 40-43 ISSN 1336-9644 R&D Projects: GA ČR GPP406/12/P603 Institutional support: RVO:68378068 Keywords : electronic literature * technology * sound poetry * perfomance * transmediality Subject RIV: AJ - Letters, Mass-media, Audiovision

Viral fusion efficacy of specific H3N2 influenza virus reassortant combinations at single-particle level

Science.gov (United States)

Hsu, Hung-Lun; Millet, Jean K.; Costello, Deirdre A.; Whittaker, Gary R.; Daniel, Susan

2016-01-01

Virus pseudotyping is a useful and safe technique for studying entry of emerging strains of influenza virus. However, few studies have compared different reassortant combinations in pseudoparticle systems, or compared entry kinetics of native viruses and their pseudotyped analogs. Here, vesicular stomatitis virus (VSV)-based pseudovirions displaying distinct influenza virus envelope proteins were tested for fusion activity. We produced VSV pseudotypes containing the prototypical X-31 (H3) HA, either alone or with strain-matched or mismatched N2 NAs. We performed single-particle fusion assays using total internal reflection fluorescence microscopy to compare hemifusion kinetics among these pairings. Results illustrate that matching pseudoparticles behaved very similarly to native virus. Pseudoparticles harboring mismatched HA-NA pairings fuse at significantly slower rates than native virus, and NA-lacking pseudoparticles exhibiting the slowest fusion rates. Relative viral membrane HA density of matching pseudoparticles was higher than in mismatching or NA-lacking pseudoparticles. An equivalent trend of HA expression level on cell membranes of HA/NA co-transfected cells was observed and intracellular trafficking of HA was affected by NA co-expression. Overall, we show that specific influenza HA-NA combinations can profoundly affect the critical role played by HA during entry, which may factor into viral fitness and the emergence of new pandemic influenza viruses. PMID:27752100

High performance fuel technology development : Development of high performance cladding materials

International Nuclear Information System (INIS)

Park, Jeongyong; Jeong, Y. H.; Park, S. Y.

2012-04-01

The superior in-pile performance of the HANA claddings have been verified by the successful irradiation test and in the Halden research reactor up to the high burn-up of 67GWD/MTU. The in-pile corrosion and creep resistances of HANA claddings were improved by 40% and 50%, respectively, over Zircaloy-4. HANA claddings have been also irradiated in the commercial reactor up to 2 reactor cycles, showing the corrosion resistance 40% better than that of ZIRLO in the same fuel assembly. Long-term out-of-pile performance tests for the candidates of the next generation cladding materials have produced the highly reliable test results. The final candidate alloys were selected and they showed the corrosion resistance 50% better than the foreign advanced claddings, which is beyond the original target. The LOCA-related properties were also improved by 20% over the foreign advanced claddings. In order to establish the optimal manufacturing process for the inner and outer claddings of the dual-cooled fuel, 18 different kinds of specimens were fabricated with various cold working and annealing conditions. Based on the performance tests and various out-of-pile test results obtained from the specimens, the optimal manufacturing process was established for the inner and outer cladding tubes of the dual-cooled fuel

Biological activities of Lavandula angustifolia essential oil

OpenAIRE

Bílková, Zuzana

2013-01-01

Zuzana Bílková, Biological activities of Lavandula angustifolia essential oil, Thesis, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, thesis author: PharmDr. Jan Martin, PhD., Hradec Králové, 2013, 72 pages. The thesis called "Biological activities of Lavandula angustifolia essential oil" is interested in biological activities of Lavandula angustifolia essential oil, specifically antifungal, antioxidant, anti-inflammatory, cytotoxicity, nematicidal and repellency activit...

The Analysis of Working Environment in terms of Diversity Management in Corporate Practice.

OpenAIRE

Indruchová, Zuzana

2014-01-01

Charles University in Prague Faculty of Arts Department of Adult Education Program: Pedagogy Zuzana Krištofová The Analysis of Working Environment in terms of Diversity Management and its Implementation in Corporate Practice Abstract thesis supervisor: Doc. PaedDr. Ludvík Eger, CSc. 2012 ABSTRACT The present doctoral thesis deals with diversity management and clarifies its concepts. The objectives of the thesis include comprehensive characterisation of diversity management as an element of co...

Impact of dissociation on treatment of depressive and anxiety spectrum disorders with and without personality disorders

OpenAIRE

Prasko, Jan; Grambal, Ales; Kasalova, Petra; Kamardova, Dana; Ociskova, Marie; Holubova, Michaela; Vrbova, Kristyna; Sigmundova, Zuzana; Latalova, Klara; Slepecky, Milos; Zatkova, Marta

2016-01-01

Jan Prasko,1 Ales Grambal,1 Petra Kasalova,1 Dana Kamardova,1 Marie Ociskova,1 Michaela Holubova,1,2 Kristyna Vrbova,1 Zuzana Sigmundova,1 Klara Latalova,1 Milos Slepecky,3 Marta Zatkova3 1Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University in Olomouc, University Hospital Olomouc, Olomouc, 2Psychiatric Department, Hospital Liberec, Liberec, Czech Republic; 3Department of Psychology Sciences, Faculty of Social Science and Health Care, Constantine the Philosopher Un...

Logopedické materiály užívané při terapii dyslalie u dospělých klientů

OpenAIRE

Brodcová, Zuzana

2012-01-01

Author's name: Zuzana Brodcová School: Charles University, Prague Title: Dyslalia materials used in speech therapy for adults Consultant: Mgr. Lucie Durdilová Number of pages: 59 Number of attachments: 1 Year of defence: 2012 Key words: logopedical care for adults with dyslalia, pronounciation of czech sounds, logopedical materials for adults with dyslalia The theme of this thesis are logopedical materials using in the therapy of adults suffering from dyslalia. The first chapter is focused on...

Influence of Dominant Body Somatotype and Sex Difference on Q ...

African Journals Online (AJOL)

Acer

musculoskeletal robustness; and ectomorphy is the relative slenderness of a physique. .... history of injured knee and knee pain for at least one year ... Bathroom weighing scale (Hana Model BR 9001: 0- ..... Indian Journal of Physiology and.

Politika trvale udržitelného rozvoje Ekvádoru v kontextu regionu Latinské Ameriky

OpenAIRE

Lhotáková, Zuzana

2016-01-01

Zuzana Lhotáková: Policy of sustainable development in Ecuador in the context of the region of Latin America Abstract Sustainable development can be defined as a strategy that enables the long-term needs of humanity to be met within the limits of natural resources. Since ecosystems of global importance (Amazon rainforests) and rich deposits of natural resources are located in Latin America, future development of this region is going to have impact on planetary level. Ecuador as a developing c...

Physiotherapy in patients with rupture LCA

OpenAIRE

Čížková, Karolína

2012-01-01

Author: Karolína Čížková Institution: Rehab clinic LF UK in Hradec Králové Topic of bachelor's thesis: Physiotherapy in patiens with rupture of ACL Supervisor: Mgr. Zuzana Hamarová Number of pages: 108 Number of annex: 11 Year of vindication 2012 Key words: ACL, knee, rupture of ACL, rehabilitation In general part of this bachelor's thesis is described anatomy, kinesiology and biomechanics of the knee joint, mostly anterior cruciate ligament. It contents causes of injury of anterior cruciate ...

Finanční zainteresovanost manažerů prodejen maloobchodních řetězců na výkonnosti prodejen -- analýza nástrojů manažerského účetnictví

OpenAIRE

Benešová, Zuzana

2009-01-01

Author of the work: Zuzana Benešová Head of the work: Ing. Jakub Stránský, CEMS MIM Goals: Analysis of the system of compensations and benefits among the retail company Ahold Czech Republic, a.s. The connection between the bonuses and store's financial results. Financial interest in other criterias such as: fresh goods, short waitlines, clean store, helpful and friendly staff,... Literature: Cimer P. & Zadražilová D. a kol, Retail Management, Management Press, Praha 2007 Drury C., Management ...

76 FR 6136 - Notice of Proposals To Engage in Permissible Nonbanking Activities or To Acquire Companies That...

Science.gov (United States)

2011-02-03

...: 1. Hana Financial Group Inc., Seoul, Korea; to acquire a controlling interest in Korea Exchange Bank, Seoul, Korea, and thereby indirectly acquire voting shares of KEB Financial Corp., New York, New York... FEDERAL RESERVE SYSTEM Notice of Proposals To Engage in Permissible Nonbanking Activities or To...

Risk based approach and interactions between interested parties in ...

African Journals Online (AJOL)

pc

2018-03-05

Mar 5, 2018 ... interested parties in QSE management systems. Hanae DAHMAN EL ... relevant interested parties participating in the logistics chain and who contribute to the ... huge logistic crossroads of loads and flows: supply of aircraft in kerosene, ... Swissport which represents the global supplier of services to the ...

Festivais Matsuris como referencial cultural e turístico da etnia japonesa em Curitiba (Paraná, Brasil

Directory of Open Access Journals (Sweden)

Miguel Bahl

2013-12-01

Full Text Available O artigo trata sobre Matsuris, festivais da etnia japonesa realizados na cidade de Curitiba, Paraná (Brasil. É um estudo de caso de caráter descritivo com a intenção de resgatar parte do histórico de imigração japonesa no Brasil, a fim de perceber a importância dos festivais Matsuris como referencial da etnia e como forma de inserção social do grupo na capital paranaense. Utilizando pesquisa bibliográfica, busca eletrônica e observação direta intensiva, o estudo traz como resultado a descrição dos três festivais mais importantes da etnia na cidade (Hana Matsuri, Imin Matsuri e Haru Matsuri, demonstrando a relação dos mesmos como referencial étnico japonês e a apresentação do resultado de pesquisa de campo empreendida em 2009, junto ao Hana Matsuri e ao Imin Matsuri. Também evidencia a importância da existência de produtos étnicos culturais para um grupo de imigrantes, principalmente em uma capital cosmopolita como Curitiba, que contemplem o significado real de sua cultura, sem que se tornem apenas um bem de consumo.  Matsuris Festivals as cultural and turistic benchmark of japonese ethnicity in Curitiba (Paraná, Brazil. The article discusses about the Matsuris, Japanese ethnic festivals realized in Curitiba, Paraná (Brazil. It is a descriptive case study that intends to briefly redeem part of the history of Japanese immigration in Brazil, in order to understand the importance of Matsuris festivals as an ethnic referential and as a kind of social insertion of the group at the capital of Paraná. Using literature search, electronic search and intensive direct observation, the study results in a description of the three most important festivals of the ethnic group in the city (Hana Matsuri, Imin Matsuri and Haru Matsuri, showing their relation as an ethnic Japanese referential and showing the result from the field research applied in 2009, during the Hana Matsuri and Imin Matsuri Festivals. It also highlights the

Jitka Folwarczna

Indian Academy of Sciences (India)

Transient expression of Human papillomavirus type 16 L2 epitope fused to N- and C-terminus of coat protein of Potato virus X in plants · Noemi Cerovska Hana Hoffmeisterova Tomas Moravec Helena Plchova Jitka Folwarczna Helena Synkova Helena Ryslava Viera Ludvikova Michal Smahel · More Details Abstract Fulltext ...

77 FR 48983 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

Science.gov (United States)

2012-08-15

..., Vice President) 33 Liberty Street, New York, New York 10045-0001: 1. Hana Financial Group Inc., Seoul, Korea; to become a bank holding company by acquiring 71.37 percent of the voting shares of BNB Financial... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The...

Estimation of the genetic diversity in tetraploid alfalfa populations based on RAPD markers for breeding purposes.

Science.gov (United States)

Nagl, Nevena; Taski-Ajdukovic, Ksenija; Barac, Goran; Baburski, Aleksandar; Seccareccia, Ivana; Milic, Dragan; Katic, Slobodan

2011-01-01

Alfalfa is an autotetraploid, allogamous and heterozygous forage legume, whose varieties are synthetic populations. Due to the complex nature of the species, information about genetic diversity of germplasm used in any alfalfa breeding program is most beneficial. The genetic diversity of five alfalfa varieties, involved in progeny tests at Institute of Field and Vegetable Crops, was characterized based on RAPD markers. A total of 60 primers were screened, out of which 17 were selected for the analysis of genetic diversity. A total of 156 polymorphic bands were generated, with 10.6 bands per primer. Number and percentage of polymorphic loci, effective number of alleles, expected heterozygosity and Shannon's information index were used to estimate genetic variation. Variety Zuzana had the highest values for all tested parameters, exhibiting the highest level of variation, whereas variety RSI 20 exhibited the lowest. Analysis of molecular variance (AMOVA) showed that 88.39% of the total genetic variation was attributed to intra-varietal variance. The cluster analysis for individual samples and varieties revealed differences in their population structures: variety Zuzana showed a very high level of genetic variation, Banat and Ghareh were divided in subpopulations, while Pecy and RSI 20 were relatively uniform. Ways of exploiting the investigated germplasm in the breeding programs are suggested in this paper, depending on their population structure and diversity. The RAPD analysis shows potential to be applied in analysis of parental populations in semi-hybrid alfalfa breeding program in both, development of new homogenous germplasm, and identification of promising, complementary germplasm.

Estimation of the Genetic Diversity in Tetraploid Alfalfa Populations Based on RAPD Markers for Breeding Purposes

Directory of Open Access Journals (Sweden)

Slobodan Katic

2011-08-01

Full Text Available Alfalfa is an autotetraploid, allogamous and heterozygous forage legume, whose varieties are synthetic populations. Due to the complex nature of the species, information about genetic diversity of germplasm used in any alfalfa breeding program is most beneficial. The genetic diversity of five alfalfa varieties, involved in progeny tests at Institute of Field and Vegetable Crops, was characterized based on RAPD markers. A total of 60 primers were screened, out of which 17 were selected for the analysis of genetic diversity. A total of 156 polymorphic bands were generated, with 10.6 bands per primer. Number and percentage of polymorphic loci, effective number of alleles, expected heterozygosity and Shannon’s information index were used to estimate genetic variation. Variety Zuzana had the highest values for all tested parameters, exhibiting the highest level of variation, whereas variety RSI 20 exhibited the lowest. Analysis of molecular variance (AMOVA showed that 88.39% of the total genetic variation was attributed to intra-varietal variance. The cluster analysis for individual samples and varieties revealed differences in their population structures: variety Zuzana showed a very high level of genetic variation, Banat and Ghareh were divided in subpopulations, while Pecy and RSI 20 were relatively uniform. Ways of exploiting the investigated germplasm in the breeding programs are suggested in this paper, depending on their population structure and diversity. The RAPD analysis shows potential to be applied in analysis of parental populations in semi-hybrid alfalfa breeding program in both, development of new homogenous germplasm, and identification of promising, complementary germplasm.

(Hyperolius marmoratus) populations

African Journals Online (AJOL)

How far can reed frogs migrate and maintain gene- flow when bced by barriers of unsuitable habitat and sepa- rated by considerable geographical distances? ..... IAGEID. S.S. 1994. Lb:tropllOn:tic and morphometric cviucl1(;c for t\\\\O species of the genus Hana (Amphibia, Ranidae) and sum oftheir vari

Reason, Science, Criticism. Joseph Agassi interviewed on his 90th birthday by Zuzana Parusniková

Czech Academy of Sciences Publication Activity Database

Parusniková, Zuzana; Agassi, J.

2017-01-01

Roč. 24, č. 4 (2017), s. 526-545 ISSN 1335-0668 Institutional support: RVO:67985955 Keywords : Joseph Agassi * interview Subject RIV: AA - Philosophy ; Religion http://klemens.sav.sk/fiusav/organon/?q=sk/reason- science -criticism

Isotopic constraints on the genesis and evolution of basanitic lavas at Haleakala, Island of Maui, Hawaii

Science.gov (United States)

Phillips, Erin H.; Sims, K.W.W.; Sherrod, David R.; Salters, Vincent; Blusztajn, Jurek; Dulaiova, Henrieta

2016-01-01

To understand the dynamics of solid mantle upwelling and melting in the Hawaiian plume, we present new major and trace element data, Nd, Sr, Hf, and Pb isotopic compositions, and 238U–230Th–226Ra and 235U–231Pa–227Ac activities for 13 Haleakala Crater nepheline normative basanites with ages ranging from ∼900 to 4100 yr B.P. These basanites of the Hana Volcanics exhibit an enrichment in incompatible trace elements and a more depleted isotopic signature than similarly aged Hawaiian shield lavas from Kilauea and Mauna Loa. Here we posit that as the Pacific lithosphere beneath the active shield volcanoes moves away from the center of the Hawaiian plume, increased incorporation of an intrinsic depleted component with relatively low 206Pb/204Pb produces the source of the basanites of the Hana Volcanics. Haleakala Crater basanites have average (230Th/238U) of 1.23 (n = 13), average age-corrected (226Ra/230Th) of 1.25 (n = 13), and average (231Pa/235U) of 1.67 (n = 4), significantly higher than Kilauea and Mauna Loa tholeiites. U-series modeling shows that solid mantle upwelling velocity for Haleakala Crater basanites ranges from ∼0.7 to 1.0 cm/yr, compared to ∼10 to 20 cm/yr for tholeiites and ∼1 to 2 cm/yr for alkali basalts. These modeling results indicate that solid mantle upwelling rates and porosity of the melting zone are lower for Hana Volcanics basanites than for shield-stage tholeiites from Kilauea and Mauna Loa and alkali basalts from Hualalai. The melting rate, which is directly proportional to both the solid mantle upwelling rate and the degree of melting, is therefore greatest in the center of the Hawaiian plume and lower on its periphery. Our results indicate that solid mantle upwelling velocity is at least 10 times higher at the center of the plume than at its periphery under Haleakala.

The content of some of the essential elements in the fruit of the (Diospyros L. persimmon of the Nikitsky Botanical Garden collection

Directory of Open Access Journals (Sweden)

С. Ю. Хохлов

2013-08-01

Full Text Available The article mentions that the special attention is deserved by such persimmon varieties being included into the collection of Garden: Nikita Burgundy – the most famous of the hardiest varieties, widely used in industrial horticulture grade foreign breeding Hana Fuyu and a new, high-yielding variety of domestic breeding Souvenir of Autumn. Plant varieties included into the studying, grow in the same conditions at the collection site, which is located 200 meters from the coast at a height of 20-40 m above its level. Trees are 15 years old, planting scheme is 6x6 meters. The selected varieties belong to the group of constant tart on their quality whose fruits are edible only when fully ripe Varieties are characterized by high winter hardiness and disease resistance, which allows minimizing the chemicals using for plants treating and creates the conditions for organic food. The chemical composition fruits studying of three oriental persimmons varieties have performed high content of potassium, so it affords their using as a general tonic. The obtained results have revealed that according to the content of essential elements the leading fruit of variety Souvenir Autumn is considered to be, the less valuable are fruits of Nikita Burgundy, and Hana Fuyu fruits on this indicator are intermediate.

Effect of burn-up on the radioactivation behavior of cladding hull materials studied using the ORIGEN-S code

International Nuclear Information System (INIS)

Min Ku Jeon; Chang Hwa Lee; Jung Hoon Choi; In Hak Cho; Kweon Ho Kang; Hwan-Seo Park; Geun Il Park; Chang Je Park

2013-01-01

The effect of fuel burn-up on the radioactivation behavior of cladding hull materials was investigated using the ORIGEN-S code for various materials of Zircaloy-4, Zirlo, HANA-4, and HANA-6 and for various fuel burn-ups of 30, 45, 60, and 75 GWD/MTU. The Zircaloy-4 material is the only one that does not contain Nb as an alloy constituent, and it was revealed that 125 Sb, 125m Te, and 55 Fe are the major sources of radioactivity. On the other hand, 93m Nb was identified as the most radioactive nuclide for the other materials although minor radioactive nuclides varied owing to their different initial constituents. The radioactivity of 94 Nb was of particular focus owing to its acceptance limit against a Korean intermediate-/low-level waste repository. The radioactivation calculation results revealed that only Zircaloy-4 is acceptable for the Korean repository, while the other materials required at least 4,900 of Nb decontamination factor owing to the high radioactivity of 94 Nb regardless of the fuel burn-up. A discussion was also made on the feasibility of Zr recovery methods (chlorination and electrorefining) for selective recovery of Zr so that it can be disposed of in the Korean repository. (author)

JPRS Report, Near East & South Asia

Science.gov (United States)

1990-09-21

States to last forever. But no mood or policy lasts forever. There is a large Arab lobby there now, and American public opinion has been influenced...interpretation of Saddam Husayn’s handwriting by Israeli graphologist Hana Qoren, who plainly and without any hesitation warned about the danger of Saddam...and sports. The adults are always correct and your ability to dispute your destiny is limited. In his childhood, he drew caricatures of Hitler

Studie chemiluminiscenčních vlastností metforminu pomocí sekvenční injekční analýzy

OpenAIRE

Horáková, Markéta

2011-01-01

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of analytical chemistry Candidate: Mgr. Markéta Horáková Consultant: PharmDr. Hana Sklenářová Ph.D. Title of Thesis: Study of chemiluminescence properties of metformin using sequential injection analysis Chemiluminescent properties of metformin were studied using a sequential injection analysis in the three systems with different composition of the reagents. The first system used potassium permanganate and sulfuric...

Kazuistika fyzioterapeutické péče o pacienta s diagnózou revmatoidní artritida

OpenAIRE

Benetková, Hana

2013-01-01

Author: Hana Benetková Title of bachelor's thesis: Case study of physiotherapy treatment of a patient with rheumatoid arthritis Summary: The aim of this bachelor's thesis is to become familiar with the issues of rheumatoid arthritis and develop case study of the patient with this diagnosis. This work is divided into general and special part. General part is focused on etiology, pathogenesis, clinical picture, diagnostics and treatment of rheumatoid arthritis. Special part was compiled on the ...

Biotransformation of selected anthelmintics in sheep tapeworm (Moniezia expansa)

OpenAIRE

Bečanová, Aneta

2013-01-01

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Aneta Bečanová Supervisor: Mgr. Hana Bártíková, Ph.D. Title of diploma thesis: Biotransformation of selected anthelmintics in sheep tapeworm (Moniezia expansa) Biotransformation of anthelmintics is a process that prevents the parasite from adverse effects of xenobiotics. Therefore, it is the main factor that causes the reduction of an anthelmintic effect, resistance development and...

Trend of Malaria Cases in Hana and Keyafer Health Centers, South ...

African Journals Online (AJOL)

2018-05-01

May 1, 2018 ... 1South Omo Education Office,. Jinka, Ethiopia. 2College of. Natural and. Computational ... the intervention methods and to plan malaria control accordingly. The aim of this ..... differences in climatic, environmental or human behavioral risk ... might be due to giving more priority to small children in the use of ...

Využití herní konzole Nintendo Wii v terapii poruch hybnosti horní končetiny

OpenAIRE

Dubová, Hana Kateřina

2013-01-01

Name: Hana Kateřina Dubová Supervizor: MUDr. Markéta Janatová Opponent: Title of the bachelor thesis: The Nintendo Wii utilization in the therapy of upper extremity motor impairments. ABSTRACT: The topic of this thesis was focused on the Nintendo Wii utilization in the therapy of upper extremity motor impairments in patients after a stroke. The aim was to demonstrate the positive effect of intensive therapy on the Nintendo Wii on the active range of motion at paretic upper extremity in two pr...

Palytoxin: a new marine toxin from a coelenterate.

Science.gov (United States)

Moore, R E; Scheuer, P J

1971-04-30

Palytoxin has been isolated from the zoanthids "limu-make-o-Hana" (Tentatively identified as Palythoa sp.) as a noncrystalline, chromatographically pure entity. Apart from polypeptide and protein toxins, it is the most highly toxic substance known, with a lethal dose (LD(59)) in mice of 0.15 microgram per kilogram by intravenous injection. Unlike the potent toxins batrachotoxin, saxitoxin, and tetrodotoxin which have molecular weights of 500 or less, palytoxin has an estimated molecular weight of 3300 and contains no repetitive amino acid or sugar units.

Walking a single path with spirit over maintenance for the past two decades

International Nuclear Information System (INIS)

2004-04-01

This book reports the 20 years history of KPS. It is divided into fire chapters, which describes history of power, development of power industry in Korea, establishment of Hana Company, the first maintenance company, early business and establishment of KEPCO, effort for management and independence for technology, man power management, establishment of Korea plant service and Engineering CO. LTD, effort for the accumulation of technology and extension of business, growth as the technical company for generation of electricity and maintenance, management innovation safety and health policy and management ethics.

Two new species of Oxynoemacheilus from the Tigris drainage in Iraqi Kurdistan (Teleostei: Nemacheilidae).

Science.gov (United States)

Freyhof, Jörg; Abdullah, Younis Sabir

2017-03-02

Two new species of Oxynoemacheilus are described from the Sirvan River drainage in Iraqi Kurdistan. Oxynoemacheilus gyndes, new species, is distinguished by having a very short lateral line, reaching behind the pectoral-fin base, no scales except on the posteriormost part of the caudal peduncle, a slightly emarginate caudal fin and no suborbital groove in males. Oxynoemacheilus hanae, new species, is distinguished by having a midlateral row of elongated blotches, isolated patches of dark-brown spots or blotches on lower flank, a deeply emarginate caudal fin and a suborbital groove in males.

Egyptské výtvarné umění XX. století a jeho role ve společnosti (se zaměřením na malbu a sochařství)

OpenAIRE

Nováková, Hana

2011-01-01

EGYPTIAN ART OF THE 20TH CENTURY AND ITS ROLE IN THE EGYPTIAN SOCIETY (CONCERNING THE ARTS OF PAINTING AND SCULPTURE Hana Nováková Abstract This thesis is a contribution to the research of the Egyptian Visual Arts in the 20th century. Egypt has long tradition of pre-Islamic and Islamic arts. Early in the 20th century the new phenomenon emerged - the modern Egyptian art. This term does not mean the visual art influenced by the modern Western art, but just the visual art influenced by the style...

Estudio de los sueros ricos en factores de crecimiento y de su efecto sobre células de epitelio corneal

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del Val Alonso, Marina

2015-01-01

Objetivos: Estudiar cómo afecta a la concentración de determinados factores de crecimiento presentes en los sueros la filtración (utilizado como método de esterilización) y el tratamiento por calor (utilizado para la inactivación del complemento). Además de estudiar el efecto de un bioadhesivo (ácido hialurónico, HaNa), aplicado solo o conjuntamente con el suero rico en factores de crecimiento (s-PRGF), sobre la capacidad de las células de epitelio corneal (HCE) para proliferar y migrar. M...

ESI-HI37 Hana, Island of Maui, Hawaii 2001 (Environmental Sensitivity Index Map)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

Thermosetting gels with modulated gelation temperature for ophthalmic use: the rheological and gamma scintigraphic studies.

Science.gov (United States)

Wei, Gang; Xu, Hui; Ding, Ping Tian; Li, San Ming; Zheng, Jun Min

2002-09-18

For ophthalmic drug delivery, Pluronic F127 solutions have a phase transition temperature too low for them to be instilled into the eye at room temperature. Refrigerator storage is usually required to make administration easier, whereas the potential irritation of cold to the sensitive ocular tissues may result in poor topical bioavailability. The purpose of this study is to develop a thermosetting gel with a suitable phase transition temperature by combining Pluronic analogs and to examine the influence of incorporating mucoadhesive polysaccharide, sodium hyaluronate (HA-Na), on the ocular retention of the gel. Dynamic rheological method and single photon emission computing tomography (SPECT) technique were used to ex/in vivo evaluate the thermosetting gels, respectively. An optimized formulation containing 21% F127 and 10% F68 increased the phase transition temperature by 9 degrees C as evaluated by elasticity modulus compared to that of individual 21% F127 solution. Rheological behaviors of the Pluronic solutions showed that the combined Pluronic formulation was free flowing liquid below 25 degrees C and converted to a firm gel under the physiological condition. Furthermore, this formulation possessed the highest viscosity both before and after tear dilution at 35 degrees C. Gamma scintigraphic data demonstrated that the clearance of the thermosetting gel labeled with 99mTc-DTPA was significantly delayed with respect to the phosphate buffered solution, and at least a threefold increase of the corneal residence time was achieved. However, no further improvement in the ocular retention was observed when adding HA-Na into the thermosetting gel due to the substantially decreased gel strength. Copyright 2002 Elsevier Science B.V.

Evaluation of size distribution of starch granules in selected wheat varieties by the Low Angle Laser Light Scattering method

International Nuclear Information System (INIS)

Capouchová, I.; Petr, J.; Marešová, D.

2003-01-01

The distribution of the size of wheat starch granules using the method LALLS (Low Angle Laser Light Scattering), followed by the evaluation of the effect of variety, experimental site and intensity of cultivation on the vol. % of the starch A (starch granules > 10 μm) was determined. The total starch content and crude protein content in dry matter of flour T530 in selected collection of five winter wheat varieties were determined. Vol. % of the starch A in evaluated collection of wheat varieties varied between 65.31 and 72.34%. The effect of a variety on the vol. % of starch A seemed to be more marked than the effect of site and intensity of cultivation. The highest vol. % of starch A reached evaluated varieties from the quality group C, i.e. varieties unsuitable for baking utilisation (except variety Contra with high total content of starch in dry matter of flour T530, but relatively low vol. % of starch A). A low vol. % of starch A was also found in the variety Hana (very good variety for baking utilisation). Certain variety differences followed from the evaluation of distribution of starch fractions of starch granules, forming starch A. In the case of varieties Hana, Contra and Siria higher representation of fractions up to 30 μm was recorded, while starch A in the varieties Estica and Versailles was formed in higher degree by size fractions of starch granules over 30 μm and particularly size fraction > 50 μm was greatest in these varieties of all evaluated samples. With increasing total starch content in dry matter of flour T530 the crude protein content decreased; the vol. % of starch A not always increased proportionally with increasing total starch content. (author)

Medizinhistorische Quellen an Wiener Universitäten

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Bauer, Bruno

2017-09-01

Full Text Available The focus of the current issue 1-2/2017 of GMS Medizin – Bibliothek – Information is on . The authors in this issue are Zuzana Ráczová (Historical Archive of the University of Veterinary Medicine Vienna, Harald Albrecht (Medical historic stock of the University Library of the Medical University of Vienna: Nine historic libraries at the Branch Library for Medical History with examples of their stocks and Walter Mentzel (Medical historic stock of the University Library of the Medical University of Vienna. Virtual libraries at the Branch Library for Medical History: Search of evidence.Furthermore this focus issue features articles by Henriette Senst and Katharina Heldt (The role of the library in the research lifecycle using the example of the Robert Koch Institute’s library. A field report, Marta Nadraga (Medical university libraries in Ukraine, Bruno Bauer (The Medical Librarian’s Bibliography 2016; 7 meeting of the AGMB working group of Austrian medical librarians (AGMB.AT at the University of Veterinary Medicine Vienna on May 15 2017 and Iris Reimann (German MLA News.

Ma ka Hana ka 'Ike (In the Work Is the Knowledge): Kaona as Rhetorical Action

Science.gov (United States)

McDougall, Brandy Nalani; Nordstrom, Georganne

2011-01-01

Malea Powell's description of composition and rhetoric's scholarship on American Indian texts echoes assertions made by Scott Richard Lyons, who writes that while the literature of the past decade demonstrates the discipline's efforts at including Native ways of knowing in scholarly discussions and classroom curricula, representations of Native…

The Famous Women Dinner Service: In Conversation with Contemporary Art

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Judy Chicago

2017-11-01

Full Text Available This conversation between Judy Chicago, The Women’s Art League, and Hana Leaper, filmed by Jonathan Law at the Elizabeth A. Sackler Center for Feminist Art, Brooklyn Museum, will be published in early 2018. The participants will discuss the Famous Women Dinner Service in relation to contemporary artworks, focusing on The Dinner Party (Judy Chicago, 1974–79 and Vagina China (The Women’s Art League, 2016–present. Questions explored will include: the role of hospitality and domesticity in feminist art projects; the evolution of iconography as it relates to aesthetic freedom and the visibility of women and their bodies; the strategies of shared authorship and collective practice; and what each of the artworks discussed offers their respective eras in terms of confronting taboos associated with women and their histories.

Induced mutations for disease resistance in wheat and barley

International Nuclear Information System (INIS)

Hanis, M.; Hanisova, A.; Knytl, V.; Cerny, J.; Benc, S.

1977-01-01

The induction of mutations in cultivars of wheat (Triticum aestivum), barley (Hordeum vulgare), and field beans (Phaseolus vulgaris) has been part of the breeding programme at the Plant Breeding Station at Stupice since 1960. A total of 26 cultivars or selections of winter wheat, 4 cultivars or selections of spring wheat, 2 cultivars of field beans, and 43 selections of spring barley have been treated since 1960. A total of 140 mutant lines of wheat and 37 mutant lines of barley with improved disease resistance of a race-specific type have been obtained. Several mutation programme derived cultivars have been registered in Czechoslovakia (''Diamant'', ''Ametyst'', ''Favorit'', ''Hana'', ''Rapid'', and ''Atlas'' in barley, and ''Alfa'' in field beans), but none of them is a mutation for disease resistance. A series of mutants have been used in crossing programmes. Approaches to improve the efficiency of mutation breeding for disease resistance are suggested. (author)

Detecção, transmissão e efeito de Xanthomonas campestris pv. campestris na qualidade fisiológica de sementes de brócolis Detection, transmission and effect of Xanthomonas campestris pv. campestris in the physiological quality of broccoli seeds

Directory of Open Access Journals (Sweden)

Nilvanira Donizeti Tebaldi

2007-12-01

Full Text Available A detecção, a transmissão e o efeito de Xanthomonas campestris pv. campestris (Xcc na qualidade fisiológica de sementes de brócolis (Brassica oleracea var. italica foram avaliados, a partir de sementes obtidas de plantas ("Baron, Flórida, Hana Midori Sakata, Precoce Piracicaba de Verão, Ramoso Santana e Sabre" inoculadas com a bactéria, em condições de campo. Para a detecção do patógeno nas sementes foram utilizados os meios de cultura semi-seletivos: SX ágar, NSCAA e BSCAA; a taxa de transmissão da bactéria pelas sementes às plântulas foi avaliada usando semeadura em areia e meio de cultura contido em tubo de ensaio. Para a avaliação da qualidade fisiológica de sementes foram realizados o teste padrão de germinação e os testes de vigor: envelhecimento acelerado, índice de velocidade de emergência, crescimento de plântulas e massa seca. De acordo com os resultados, o meio de cultura semi-seletivo NSCAA foi mais eficaz para detectar Xcc em sementes de brócolis; não houve diferença significativa entre os genótipos na taxa de transmissão da bactéria pelas sementes e Xcc não afetou a germinação e o vigor das sementes.The detection, transmission and the effect of Xanthomomas campestris pv. campestris (Xcc in the physiological quality of broccoli seeds were evaluated. The seeds were obtained from inoculated field plants (`Baron', `Flórida', `Hana Midori Sakata', `Precoce Piracicaba de Verão', `Ramoso Santana' and `Sabre' genotypes with the bacterium. For the seed pathogen detection the semi-selective medium were used: starch for xanthomonads (SX agar, nutrient starch cycloheximide antibiotic agar (NSCAA and basal starch cycloheximide antibiotic agar (BSCAA; the bacteria seeds transmission percentage was evaluated using sand and test tube. The physiological seed quality was evaluated by the standard germination and vigor tests: the accelerated aging, speed of emergence, seedling growth and seedling dry weight. The

Detecção, transmissão e efeito de Xanthomonas campestris pv. campestris na qualidade fisiológica de sementes de brócolis Detection, transmission and effect of Xanthomonas campestris pv. campestris in the physiological quality of broccoli seeds

Directory of Open Access Journals (Sweden)

Nilvanira Donizete Tebaldi

2007-09-01

Full Text Available A detecção, a transmissão e o efeito de Xanthomonas campestris pv. campestris (Xcc na qualidade fisiológica de sementes de brócolis (Brassica oleracea var. italica foram avaliadas, a partir de sementes obtidas de plantas ("Baron, Flórida, Hana Midori Sakata, Precoce Piracicaba de Verão, Ramoso Santana e Sabre" inoculadas com a bactéria, em condições de campo. Para a detecção do patógeno nas sementes foram utilizados os meios de cultura semi-seletivos: SX ágar, NSCAA e BSCAA; a taxa de transmissão da bactéria pelas sementes às plântulas foi avaliada usando semeadura em areia e meio de cultura contido em tubo de ensaio. Para a avaliação da qualidade fisiológica das sementes foram realizados o teste padrão de germinação e os testes de vigor: envelhecimento acelerado, índice de velocidade de emergência, crescimento das plântulas e massa seca. De acordo com os resultados, o meio de cultura semi-seletivo NSCAA foi mais eficaz para detectar Xcc em sementes de brócolis; não houve diferença significativa entre os genótipos na taxa de transmissão da bactéria pelas sementes e Xcc não afetou a germinação e o vigor das sementes.The detection, transmission and the effect of Xanthomomas campestris pv. campestris (Xcc in the physiological quality of broccoli seeds were evaluated. The seeds were obtained from inoculated field plants ('Baron', 'Flórida', 'Hana Midori Sakata', 'Precoce Piracicaba de Verão', 'Ramoso Santana' and 'Sabre' genotypes with the bacterium. For the seed pathogen detection the semi-selective medium were used: starch for xanthomonads (SX agar, nutrient starch cycloheximide antibiotic agar (NSCAA and basal starch cycloheximide antibiotic agar (BSCAA; the bacteria seeds transmission percentage was evaluated using sand and test tube. The physiological seed quality was evaluated by the standard germination and vigor tests: the accelerated aging, speed of emergence, seedling growth and seedling dry weight

High performance fuel technology development

Energy Technology Data Exchange (ETDEWEB)

Koon, Yang Hyun; Kim, Keon Sik; Park, Jeong Yong; Yang, Yong Sik; In, Wang Kee; Kim, Hyung Kyu [KAERI, Daejeon (Korea, Republic of)

2012-01-15

{omicron} Development of High Plasticity and Annular Pellet - Development of strong candidates of ultra high burn-up fuel pellets for a PCI remedy - Development of fabrication technology of annular fuel pellet {omicron} Development of High Performance Cladding Materials - Irradiation test of HANA claddings in Halden research reactor and the evaluation of the in-pile performance - Development of the final candidates for the next generation cladding materials. - Development of the manufacturing technology for the dual-cooled fuel cladding tubes. {omicron} Irradiated Fuel Performance Evaluation Technology Development - Development of performance analysis code system for the dual-cooled fuel - Development of fuel performance-proving technology {omicron} Feasibility Studies on Dual-Cooled Annular Fuel Core - Analysis on the property of a reactor core with dual-cooled fuel - Feasibility evaluation on the dual-cooled fuel core {omicron} Development of Design Technology for Dual-Cooled Fuel Structure - Definition of technical issues and invention of concept for dual-cooled fuel structure - Basic design and development of main structure components for dual- cooled fuel - Basic design of a dual-cooled fuel rod.

Cinematic shots and cuts: on the ethics and semiotics of real violence in film fiction

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Erik van Ooijen

2011-05-01

Full Text Available In this article I discuss a few ethical and semiotic problems related to reality's ability to actually take place within, and break through, fictional representations. I am particularly concerned with the presence of material bodies in the performing arts. I consider Hideshi Hino's Flower of Flesh and Blood (Ginî piggu 2: Chiniku no hana, 1985 as an initial example of purely fictional film violence. From a brief presentation of traditional theatre semiotics and the concept of a fictive stance, I then discuss two specific films where the body of the actor functions not only as the carrier of symbolical meaning but also as an indexical reference to a factual situation: John Waters’ Pink Flamingos (1972 and Ruggero Deodato's Cannibal Holocaust (1980. My main interest lies in the occurrence of real violence, and particularly animal killings, in exploitation cinema. By considering directors’ own statements on the matter, I suggest that such violence can not simply be dismissed as ethically flawed; rather, it carries a potential critique of the ideology of meat as pure commodity.

A pluralist challenge to "integrative medicine": Feyerabend and Popper on the cognitive value of alternative medicine.

Science.gov (United States)

Kidd, Ian James

2013-09-01

This paper is a critique of 'integrative medicine' as an ideal of medical progress on the grounds that it fails to realise the cognitive value of alternative medicine. After a brief account of the cognitive value of alternative medicine, I outline the form of 'integrative medicine' defended by the late Stephen Straus, former director of the US National Centre for Complementary and Alternative Medicine. Straus' account is then considered in the light of Zuzana Parusnikova's recent criticism of 'integrative medicine' and her distinction between 'cognitive' and 'opportunistic' engagement with alternative medicine. Parusnikova warns that the medical establishment is guilty of 'dogmatism' and proposes that one can usefully invoke Karl Popper's 'critical rationalism' as an antidote. Using the example of Straus, I argue that an appeal to Popper is insufficient, on the grounds that 'integrative medicine' can class as a form of cognitively-productive, critical engagement. I suggest that Parusnikova's appeal to Popper should be augmented with Paul Feyerabend's emphasis upon the role of 'radical alternatives' in maximising criticism. 'Integrative medicine' fails to maximise criticism because it 'translates' alternative medicine into the theories and terminology of allopathic medicine and so erodes its capacity to provide cognitively-valuable 'radical alternatives'. These claims are then illustrated with a discussion of 'traditional' and 'medical' acupuncture. I conclude that 'integrative medicine' fails to exploit the cognitive value of alternative medicine and so should be rejected as an ideal of medical progress. Copyright © 2013 Elsevier Ltd. All rights reserved.

Components of effective randomized controlled trials of hydrotherapy programs for fibromyalgia syndrome: A systematic review

Directory of Open Access Journals (Sweden)

Luke Perraton

2009-11-01

Full Text Available Luke Perraton, Zuzana Machotka, Saravana KumarInternational Centre for Allied Health Evidence, University of South Australia, Adelaide, South Australia, AustraliaAim: Previous systematic reviews have found hydrotherapy to be an effective management strategy for fibromyalgia syndrome (FMS. The aim of this systematic review was to summarize the components of hydrotherapy programs used in randomized controlled trials.Method: A systematic review of randomized controlled trials was conducted. Only trials that have reported significant FMS-related outcomes were included. Data relating to the components of hydrotherapy programs (exercise type, duration, frequency and intensity, environmental factors, and service delivery were analyzed.Results: Eleven randomized controlled trials were included in this review. Overall, the quality of trials was good. Aerobic exercise featured in all 11 trials and the majority of hydrotherapy programs included either a strengthening or flexibility component. Great variability was noted in both the environmental components of hydrotherapy programs and service delivery.Conclusions: Aerobic exercise, warm up and cool-down periods and relaxation exercises are common features of hydrotherapy programs that report significant FMS-related outcomes. Treatment duration of 60 minutes, frequency of three sessions per week and an intensity equivalent to 60%–80% maximum heart rate were the most commonly reported exercise components. Exercise appears to be the most important component of an effective hydrotherapy program for FMS, particularly when considering mental health-related outcomes.Keywords: hydrotherapy, fibromyalgia syndrome, exercise, effective, components

Agua, arquitectura y poder en una capital del Islam: la finca real del Agdal de Marrakech (ss. XII-XX

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Navarro Palazón, Julio

2013-12-01

Full Text Available The Agdal is a royal country estate located to the South of Marrakech and annexed to the kasba, founded in the Almohad period. The current enclosure is an area of 340 ha and consists mainly of orchards farmed uninterruptedly for centuries. Over 40 preserved buildings and numerous archaeological remains have been catalogued in its interior. Among these remains, the enclosure of the Dar al-Hana has been identified with the residential area of the Almohad and Saadian periods. In the southern area of this complex, the remains of a large central court Saadian palace, built on a previous Almohad one, have been identified. The enlargement of the Agdal northwards, which converted an isolated country estate (an almunia into an appendix of the kasba, has been also recorded. The archeological prospection of the Tasltante plain, close to the Agdal, has allowed defining a model of country state and a settlement pattern, which is also followed by this royal property. The archaeological information and the analysis of the written sources have made possible to reconstruct the Agdal and the peri-urban landscape previous to the Alaouite restoration of the imperial capital status to Marrakech in the eighteenth century.El Agdal es una finca real situada al sur de Marrakech y anexa a la kasba, fundada en época almohade. El perímetro amurallado actual contiene 340 ha que en su mayor parte son huertas que se han mantenido cultivadas ininterrumpidamente. En su interior se han estudiado más de 40 edificios conservados y numerosos restos arqueológicos; los más significativos han permitido identificar el recinto de Dar al-Hana como el área residencial de la finca almohade y saadí. Al sur de este recinto se han localizado los restos de un gran palacio saadí de patio central, edificado sobre otro más antiguo de época almohade. La prospección arqueológica origen de la presente investigación ha documentado el proceso de expansión del Agdal hacia el norte, que

Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis

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Payne CM

2011-05-01

Full Text Available Claire M Payne, Cheray Crowley-Skillicorn, Carol Bernstein, Hana Holubec, Harris BernsteinDepartment of Cell Biology and Anatomy, College of Medicine, University of Arizona Tucson, AZ, USAAbstract: Chromosomal instability is a major pathway of sporadic colon carcinogenesis. Chromosome arm 1p appears to be one of the “hot spots” in the non-neoplastic mucosa that, when deleted, is associated with the initiation of carcinogenesis. Chromosome arm 1p contains genes associated with DNA repair, spindle checkpoint function, apoptosis, multiple microRNAs, the Wnt signaling pathway, tumor suppression, antioxidant activities, and defense against environmental toxins. Loss of 1p is dangerous since it would likely contribute to genomic instability leading to tumorigenesis. The 1p deletion-associated colon carcinogenesis pathways are reviewed at the molecular and cellular levels. Sporadic colon cancer is strongly linked to a high-fat/low-vegetable/low-micronutrient, Western-style diet. We also consider how selected dietary-related compounds (eg, excess hydrophobic bile acids, and low levels of folic acid, niacin, plant-derived antioxidants, and other modulatory compounds might affect processes leading to chromosomal deletions, and to the molecular and cellular pathways specifically altered by chromosome 1p loss.Keywords: chromosome 1p, colon carcinogenesis, molecular pathways, cellular pathways

Neuraminidase and hemagglutinin matching patterns of a highly pathogenic avian and two pandemic H1N1 influenza A viruses.

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Yonghui Zhang

Full Text Available BACKGROUND: Influenza A virus displays strong reassortment characteristics, which enable it to achieve adaptation in human infection. Surveying the reassortment and virulence of novel viruses is important in the prevention and control of an influenza pandemic. Meanwhile, studying the mechanism of reassortment may accelerate the development of anti-influenza strategies. METHODOLOGY/PRINCIPAL FINDINGS: The hemagglutinin (HA and neuraminidase (NA matching patterns of two pandemic H1N1 viruses (the 1918 and current 2009 strains and a highly pathogenic avian influenza A virus (H5N1 were studied using a pseudotyped particle (pp system. Our data showed that four of the six chimeric HA/NA combinations could produce infectious pps, and that some of the chimeric pps had greater infectivity than did their ancestors, raising the possibility of reassortment among these viruses. The NA of H5N1 (A/Anhui/1/2005 could hardly reassort with the HAs of the two H1N1 viruses. Many biological characteristics of HA and NA, including infectivity, hemagglutinating ability, and NA activity, are dependent on their matching pattern. CONCLUSIONS/SIGNIFICANCE: Our data suggest the existence of an interaction between HA and NA, and the HA NA matching pattern is critical for valid viral reassortment.

Salvage therapies in relapsed and/or refractory myeloma: what is current and what is the future?

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Thumallapally N

2016-08-01

Full Text Available Nishitha Thumallapally,1 Hana Yu,1 Divya Asti,1 Adarsh Vennepureddy,1 Terenig Terjanian2 1Department of Internal Medicine, 2Division of Hematology and Oncology, Staten Island University Hospital, New York, NY, USA Abstract: The treatment landscape for multiple myeloma (MM is evolving with our understanding of its pathophysiology. However, given the inevitable cohort heterogeneity in salvage therapy, response to treatment and overall prognoses tend to vary widely, making meaningful conclusions about treatment efficacy difficult to derive. Despite the hurdles in current research, progress is underway toward more targeted therapeutic approaches. Several new drugs with novel mechanism of action and less toxic profile have been developed in the past decade, with the potential for use as single agents or in synergy with other treatment modalities in MM therapy. As our discovery of these emerging therapies progresses, so too does our need to reshape our knowledge on knowing how to apply them. This review highlights some of the recent landmark changes in MM management with specific emphasis on salvage drugs available for relapsed and refractory MM and also discusses some of the upcoming cutting-edge therapies that are currently in various stages of clinical development. Keywords: multiple myeloma, novel drugs, relapsed and refractory myeloma, salvage chemotherapy 

Irradiation of Parts of the X-Gen Nuclear Fuel Assembly made by KNF in HANARO

International Nuclear Information System (INIS)

Choo, K. N.; Cho, M. S.; Shin, Y. T.; Kim, B. G.; Lee, S. H.; Eom, K. B.

2008-01-01

An instrumented capsule has been developed at HANARO (High flux Advanced Neutron Application ReactOr) for the neutron irradiation tests of materials. The capsule system has been actively utilized for the various material irradiation tests requested by users from research institutes, universities, and the industries. As a preliminary test, some specimens made of the parts of a nuclear fuel assembly were inserted in the 05M-07U instrumented capsule and successfully irradiated at HANARO. Based on the results and experience, a new irradiation capsule of 07M-13N was designed, fabricated, and irradiated at HANARO for the evaluation of the neutron irradiation properties of the parts of the X-Gen nuclear fuel assembly made by KNF (Korea Nuclear Fuel). Specimens such as bucking and spring test specimens of spacer grid, microstructure and tensile test specimens of welded parts, tensile, irradiation growth and spring test specimens made of HANA tube, Zirlo, Zircaloy-4 and Inconel-718 were placed in the capsule. The capsule was loaded into the CT test hole of HANARO of a 30MW thermal output and the specimens were irradiated at 295 - 460 .deg. C up to a fast neutron fluence of 1.2x10 21 (n/cm 2 ) (E>1.0MeV)

General geology and ground-water resources of the island of Maui, Hawaii

Science.gov (United States)

Stearns, Harold T.; Macdonald, Gordon Andrew

1942-01-01

level. Covering this dome are the Kula volcanics, extruded probably in early and middle Pleistocene time, and characterized by andesites, andesitic basalts, and picritic basalts. They are 2.000 feet thick on the summit and 50 to 200 feet thick at the periphery. They contain a sufficient number of interbedded soils, thin vitric tuff beds, and lava-filled valleys in their upper part to give rise to valuable perched springs in wet areas. The Kula lavas accumulated during a waning volcanic phase which was followed by a quiescence long enough for the erosion of deep amphitheater-headed valleys in the east or wet half of the mountain. Volcanic activity was renewed in middle (?) to late Pleistocene time and continued until Recent time, during which the Hana volcanic series was laid down. The last lava flow was erupted about 1750. The Hana lavas comprise andesitic, picritic, and olivine basalts. They veneered large areas of the east and south slopes, partly filled the deep amphitheater-headed valleys, and deeply buried the smaller valleys in the eastern half of the mountain. The Hana rocks are exceedingly permeable and much rain sinks into them.The oldest rocks on West Maui are the very permeable primitive Wailuku basalts, which were extruded probably in Pliocene and early Pleistocene time from two rifts and from many radial fissures. The basalts form a dome about 5,600 feet high and extend an unknown distance below sea level. Iao Valley is the eroded caldera of this dome. Forming an incomplete veneer over the dome are the Honolua soda trachytes and oligoclase andesites. They were extruded in late Pliocene (?) or early Pleistocene time, chiefly from bulbous domes. The clinker beds carry some water but the rocks are generally too dense to be good aquifers. During early (?) Pleistocene the West Maui volcano was cut by deep amphitheater-headed valleys and then all of Maui was deeply submerged. Four scattered eruptions occurred on West Maui in middle (?) and late Pleistocene time

Hendra and Nipah viruses: pathogenesis, animal models and recent breakthroughs in vaccination

Directory of Open Access Journals (Sweden)

Weingartl HM

2015-09-01

Full Text Available Hana M Weingartl National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB, Canada Abstract: Hendra and Nipah viruses are two highly pathogenic zoonotic members of the genus Henipavirus, family Paramyxoviridae, requiring work under biosafety level 4 conditions due to a lack of effective therapy and human vaccines. Several vaccine candidates were protective in animal models: recombinant vaccinia virus expressing Nipah virus (NiV F and G proteins in hamsters against NiV; recombinant ALVAC–NiV F and G in swine against NiV; recombinant Hendra virus (HeV soluble G protein (sGHeV against HeV and NiV in cats, ferrets, horses, and African green monkeys (AGM; recombinant vesicular stomatitis virus-based vectors expressing NiV F or G against NiV in hamsters and ferrets; measles virus-based NiV G vaccine candidate in hamsters and AGMs against NiV; and adenoassociated virus expressing NiG protein, which protected hamsters against NiV. The sGHeV was licensed for use in horses (Equivac HeV® in 2012. It is the first vaccine candidate licensed against a biosafety level 4 agent. With the development of suitable animal models (ferret, hamster and, importantly, AGM, progress can be made toward development of a human vaccine.Keywords: henipavirus, equine, swine, human infection, animal models, vaccine candidates

Mutation breedings in ornamental plants

International Nuclear Information System (INIS)

Matsubara, Hisao

1984-01-01

Several methods of obtaining somatic mutant plants by γ-ray irradiation on pieces of tissues as in vitro adventitious bud technique or small cutting methods with repeated pruning are described. 1) The irradiation to the adventitious buds in the small pieces of organ cultured in vitro and to the small cuttings are employed. Culture beds of agar or of Japanese Kanuma soil were used in vitro culture. In these experiments, Japanese Kanuma soil bed in in vitro culture worked well for root development and transplant of the induced mutants. 2) Combination with in vitro culture and repeated pruning technique were used for isolation and fixation of solid somatic mutant from small sectorial mutation induced by irradiation. This method was successful for begonia, chrysanthemum, aberia and winter daphne. 3) These data indicates that most of the induced mutant plants were non-chimeric, while a few others were chimeric. Among the new varieties, ''Gin-Sei'', ''Ryoku-Ha'', ''Big-Cross'', ''Kaede-Iron'', ''Mei-Fu-Hana-Tsukubane-Utsugi'' and ''Daphne-γ-3'' are non-chimeric, and ''Mini-Mini-Iron'' and ''Orange-Iron'' are chimeric. Moreover, these new varieties have remarkably differed in size and in color pattern from original variety. From the experimental results of somatic mutation, it is indicated that plant tissue culture have enormous potential in radiation breeding and in rapid propagation of the somatic mutant. (author)

Surveillance and Outbreak Response Management System (SORMAS) to support the control of the Ebola virus disease outbreak in West Africa.

Science.gov (United States)

Fähnrich, C; Denecke, K; Adeoye, O O; Benzler, J; Claus, H; Kirchner, G; Mall, S; Richter, R; Schapranow, M P; Schwarz, N; Tom-Aba, D; Uflacker, M; Poggensee, G; Krause, G

2015-03-26

In the context of controlling the current outbreak of Ebola virus disease (EVD), the World Health Organization claimed that 'critical determinant of epidemic size appears to be the speed of implementation of rigorous control measures', i.e. immediate follow-up of contact persons during 21 days after exposure, isolation and treatment of cases, decontamination, and safe burials. We developed the Surveillance and Outbreak Response Management System (SORMAS) to improve efficiency and timeliness of these measures. We used the Design Thinking methodology to systematically analyse experiences from field workers and the Ebola Emergency Operations Centre (EOC) after successful control of the EVD outbreak in Nigeria. We developed a process model with seven personas representing the procedures of EVD outbreak control. The SORMAS system architecture combines latest In-Memory Database (IMDB) technology via SAP HANA (in-memory, relational database management system), enabling interactive data analyses, and established SAP cloud tools, such as SAP Afaria (a mobile device management software). The user interface consists of specific front-ends for smartphones and tablet devices, which are independent from physical configurations. SORMAS allows real-time, bidirectional information exchange between field workers and the EOC, ensures supervision of contact follow-up, automated status reports, and GPS tracking. SORMAS may become a platform for outbreak management and improved routine surveillance of any infectious disease. Furthermore, the SORMAS process model may serve as framework for EVD outbreak modeling.

Neodymium doped hydroxyapatite theranostic nanoplatforms for colon specific drug delivery applications.

Science.gov (United States)

Victor, Sunita Prem; Paul, Willi; Vineeth, V M; Komeri, Remya; Jayabalan, Muthu; Sharma, Chandra P

2016-09-01

Theranostic nanoplatforms integrate therapeutic payloads with diagnostic agents, and help monitor therapeutic response. In this regard, stimuli responsive nanoplatforms further favour combinatorial therapeutic approach that can considerably improve efficacy and specificity of treatment. Herein, we present the engineering of a smart theranostic nanoplatform based on neodymium doped hydroxyapatite (HAN). The presence of neodymium endows the HAN nanoplatforms with near-infrared fluorescence capability. These HAN nanoparticles were then subsequently modified with alginic acid (HANA) to confer pH responsiveness to the synthesized nanoplatforms delivering them to the colon after oral administration. These nanoplatforms possessing optimum size, needle shaped morphology and negative zeta potential, are conducive to cellular internalization. On excitation at 410nm they exhibit near infrared emission at 670nm unraveling their theranostic capabilities. Cytotoxic effects systematically assessed using MTT and live dead assays reveal excellent viability. Raman microscopic imaging technique used to visualize uptake in HeLa cells demonstrate increased uptake from 4 to 16h, with growing cluster size and localization in the cytoplasm. Moreover the concomitant presence of alginic acid manifested advantages of augmented loading and pH dependent release profiles of the model drug, 4 acetyl salicylic acid (4ASA). We could thus establish a theranostic system for early tumour detection, targeted tumour therapy and monitoring of colon cancer that can be administered via the oral route. Copyright © 2016 Elsevier B.V. All rights reserved.

Osteogenic cell differentiation on H-terminated and O-terminated nanocrystalline diamond films

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Liskova J

2015-01-01

Full Text Available Jana Liskova,1 Oleg Babchenko,2 Marian Varga,2 Alexander Kromka,2 Daniel Hadraba,1 Zdenek Svindrych,1 Zuzana Burdikova,1 Lucie Bacakova1 1Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic; 2Institute of Physics, Academy of Sciences of the Czech Republic, Prague, Czech Republic Abstract: Nanocrystalline diamond (NCD films are promising materials for bone implant coatings because of their biocompatibility, chemical resistance, and mechanical hardness. Moreover, NCD wettability can be tailored by grafting specific atoms. The NCD films used in this study were grown on silicon substrates by microwave plasma-enhanced chemical vapor deposition and grafted by hydrogen atoms (H-termination or oxygen atoms (O-termination. Human osteoblast-like Saos-2 cells were used for biological studies on H-terminated and O-terminated NCD films. The adhesion, growth, and subsequent differentiation of the osteoblasts on NCD films were examined, and the extracellular matrix production and composition were quantified. The osteoblasts that had been cultivated on the O-terminated NCD films exhibited a higher growth rate than those grown on the H-terminated NCD films. The mature collagen fibers were detected in Saos-2 cells on both the H-terminated and O-terminated NCD films; however, the quantity of total collagen in the extracellular matrix was higher on the O-terminated NCD films, as were the amounts of calcium deposition and alkaline phosphatase activity. Nevertheless, the expression of genes for osteogenic markers – type I collagen, alkaline phosphatase, and osteocalcin – was either comparable on the H-terminated and O-terminated films or even lower on the O-terminated films. In conclusion, the higher wettability of the O-terminated NCD films is promising for adhesion and growth of osteoblasts. In addition, the O-terminated surface also seems to support the deposition of extracellular matrix proteins and extracellular matrix

Diagnosing COPD: advances in training and practice – a systematic review

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Koblizek V

2016-04-01

Full Text Available Vladimir Koblizek,1,2 Barbora Novotna,1–3 Zuzana Zbozinkova,3 Karel Hejduk31Department of Pneumology, University Hospital Hradec Kralove, Hradec Králové, Czech Republic; 2Faculty of Medicine in Hradec Kralove, Charles University in Prague, Hradec Králové, Czech Republic; 3Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech RepublicAbstract: Chronic obstructive pulmonary disease (COPD is a chronic inflammatory lung syndrome, caused by long-term inhalation of noxious gases and particles, which leads to gradual airflow limitation. All health care professionals who care for COPD patients should have full access to high-quality spirometry testing, as postbronchodilator spirometry constitutes the principal method of COPD diagnosis. One out of four smokers 45 years or older presenting respiratory symptoms in primary care, have non-fully reversible airflow limitation compatible with COPD and are mostly without a known diagnosis. Approximately 50.0%–98.3% of patients are undiagnosed worldwide. The majority of undiagnosed COPD patients are isolated at home, are in nursing or senior-assisted living facilities, or are present in oncology and cardiology clinics as patients with lung cancers and coronary artery disease. At this time, the prevalence and mortality of COPD subjects is increasing, rapidly among women who are more susceptible to risk factors. Since effective management strategies are currently available for all phenotypes of COPD, correctly performed and well-interpreted postbronchodilator spirometry is still an essential component of all approaches used. Simple educational training can substantially improve physicians’ knowledge relating to COPD diagnosis. Similarly, a physician inhaler education program can improve attitudes toward inhaler teaching and facilitate its implementation in routine clinical practices. Spirometry combined with inhaled technique education improves the ability of

The relationship of C-reactive protein levels and positive culture with quality of life in acute rhinosinusitis

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Schalek P

2015-01-01

Full Text Available Petr Schalek, Zuzana Hornáčková, Aleš Hahn Ear, Nose and Throat department, 3rd Medical Faculty of Charles University, Prague, Czech Republic Background: Acute rhinosinusitis (ARS has been shown to significantly reduce patient quality of life (QoL. While the QoL in patients with chronic rhinosinusitis has been the subject of intensive research over the last decade, studies measuring the impact of ARS on patient QoL have remained relatively scarce. The aim of this study was to determine the relationship between the QoL and parameters suggestive of acute bacterial rhinosinusitis (C-reactive protein [CRP] levels and positive culture and to see if measurement of the QoL could be used as an indicator for antibiotic treatment in ARS.Methods: Eighty patients with ARS were enrolled in the study. A novel QoL instrument for patients with ARS, called Measurement of Acute Rhinosinusitis (MARS questionnaire, was given to patients at the time of diagnosis. We assessed patient QoL, obtained endoscopically guided cultures from the middle meatus, and measured levels of CRP. The relationship between QoL MARS scores (QoL-Mscores and CRP was determined using a correlation coefficient. To compare QoL-Mscores, relative to culture-positive and culture-negative patients, the Student’s t-test was used.Results: No correlation between the QoL, assessed using the MARS questionnaire, and positive middle meatus culture was demonstrated (P=0.332. A weak correlation was found between QoL-Mscores and CRP values, with a correlation coefficient of 0.221 and P=0.0498.Conclusion: No correlation between the QoL in ARS patients and positive culture was found in this study. The clinical significance of the correlation between QoL-Mscores and CRP values in the antibiotic decision making process needs further research. Keywords: endoscopy, quality of life, questionnaires, anti-bacterial agents

Coping strategies, hope, and treatment efficacy in pharmacoresistant inpatients with neurotic spectrum disorders

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Ociskova M

2015-05-01

Full Text Available Marie Ociskova,1,2 Jan Prasko,2 Dana Kamaradova,2 Ales Grambal,2 Petra Kasalova,2 Zuzana Sigmundova,2 Klara Latalova,2 Kristyna Vrbova2 1Department of Psychology, Faculty of Arts, 2Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, Czech Republic Background: Approximately 30%–60% of patients with neurotic spectrum disorders remain symptomatic despite treatment. Identifying the predictors of good response to psychiatric and psychotherapeutic treatment may be useful for increasing treatment efficacy in neurotic patients. The objective of this study was to investigate the influence of hope, coping strategies, and dissociation on the treatment response of this group of patients.Methods: Pharmacoresistant patients, who underwent a 6-week psychotherapeutic program, were enrolled in the study. All patients completed the Clinical Global Impression (CGI – both objective and subjective forms, Beck Anxiety Inventory (BAI, and Beck Depression Inventory (BDI-II at baseline and after 6 weeks. The COPE Inventory, the Adult Dispositional Hope Scale (ADHS, and the Dissociative Experiences Scale (DES were completed at the start of the treatment.Results: Seventy-six patients completed the study. The mean scores for all scales measuring the severity of the disorders (BAI, BDI-II, subjective and objective CGI significantly decreased during the treatment. Several subscores of the COPE Inventory, the overall score of ADHS, and the overall score of DES significantly correlated with the treatment outcome. Multiple regression was used to find out which factors were the most significant predictors of the therapeutic outcomes. The most important predictors of the treatment response were the overall levels of hope and dissociation.Conclusion: According to our results, a group of patients with a primary neurotic disorder, who prefer the use of maladaptive coping strategies, feel hopelessness, and

Expanded DMPK repeats in dizygotic twins referred for diagnosis of autism versus absence of expanded DMPK repeats at screening of 330 children with autism

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Musova Z

2016-09-01

Full Text Available Zuzana Musova,1 Miroslava Hancarova,1 Marketa Havlovicova,1 Radka Pourova,1 Michal Hrdlicka,2 Josef Kraus,3 Marie Trkova,4 David Stejskal,4 Zdenek Sedlacek1 1Department of Biology and Medical Genetics, 2Department of Child Psychiatry, 3Department of Child Neurology, Charles University 2nd Faculty of Medicine and University Hospital Motol, 4Gennet, Centre for Fetal Medicine, Prague, Czech Republic Abstract: Myotonic dystrophy type 1 (DM1 belongs to the broad spectrum of genetic disorders associated with autism spectrum disorders (ASD. ASD were reported predominantly in congenital and early childhood forms of DM1. We describe dizygotic twin boys with ASD who were referred for routine laboratory genetic testing and in whom karyotyping, FMR1 gene testing, and single nucleotide polymorphism array analysis yielded negative results. The father of the boys was later diagnosed with suspected DM1, and testing revealed characteristic DMPK gene expansions in his genome as well as in the genomes of both twins and their elder brother, who also suffered from ASD. In accord with previous reports on childhood forms of DM1, our patients showed prominent neuropsychiatric phenotypes characterized especially by hypotonia, developmental and language delay, emotional and affective lability, lowered adaptability, and social withdrawal. The experience with this family and multiple literature reports of ASD in DM1 on the one side but the lack of literature data on the frequency of DMPK gene expansions in ASD patients on the other side prompted us to screen the DMPK gene in a sample of 330 patients with ASD who were first seen by a geneticist before they were 10 years of age, before the muscular weakness, which may signal DM1, usually becomes obvious. The absence of any DMPK gene expansions in this cohort indicates that targeted DMPK gene testing can be recommended only in ASD patients with specific symptoms or family history suggestive of DM1. Keywords: autism, myotonic

Irradiation Test in HANARO of the Parts of an X-Gen Nuclear Fuel Assembly

Energy Technology Data Exchange (ETDEWEB)

Choo, K. N.; Kim, B. G.; Kang, Y. H. (and others)

2008-08-15

An instrumented capsule of 07M-13N was designed, fabricated and irradiated for an evaluation of the neutron irradiation properties of the parts of an X-Gen nuclear fuel assembly for PWR requested by KNF. Some specimens requested by Westinghouse Co. and Hanyang university were also inserted. 389 KNF specimens such as bucking and spring test specimens of 1x1 cell spacer grid, tensile, microstructure and tensile of welded parts, irradiation growth, spring test specimens made of HANA tube, Zirlo, Zircaloy-4, Inconel-718 were placed in the capsule. The capsule was composed of 5 stages having many kinds of specimens and an independent electric heater at each stage. During the irradiation test, the temperature of the specimens and the thermal/fast neutron fluences were measured by 14 thermocouples and 7 sets of Ni-Ti-Fe (2 sets contain additional Nb-Ag) neutron fluence monitors installed in the capsule. The capsule was irradiated for 59.19days (4 cycles) in the CT test hole of HANARO of a 30MW thermal output at 300 {approx} 420 .deg. C(for KNF specimens) up to a fast neutron fluence of 1.27x10{sup 21}(n/cm{sup 2}) (E>1MeV). After an irradiation test, the main body of the capsule was cut off at the bottom of the protection tube with a cutting system and it was transported to the IMEF (Irradiated Materials Examination Facility). The irradiated specimens were tested to evaluate the irradiation performance of the parts of an X-Gen fuel assembly in the IMEF hot cell.

High Performance Fuel Technology Development(I)

International Nuclear Information System (INIS)

Song, Kun Woo; Kim, Keon Sik; Bang, Jeong Yong; Park, Je Keon; Chen, Tae Hyun; Kim, Hyung Kyu

2010-04-01

The dual-cooled annular fuel has been investigated for the purpose of achieving the power uprate of 20% and decreasing pellet temperature by 30%. The 12x12 rod array and basic design was developed, which is mechanically compatible with the OPR-1000. The reactor core analysis has been performed using this design, and the results have shown that the criteria of nuclear, thermohydraulic and safety design are satisfied and pellet temperature can be lowered by 40% even in 120% power. The basic design of fuel component was developed and the cladding thickness was designed through analysis and experiments. The solutions have been proposed and analyzed to the technical issues such as 'inner channel blockage' and 'imbalance between inner and outer coolant'. The annular pellet was fabricated with good control of shape and size, and especially, a new sintering technique has been developed to control the deviation of inner diameter within ±5μm. The irradiation test of annular pellets has been conducted up to 10 MWD/kgU to find out the densification and swelling behaviors. The 11 types of materials candidates have developed for the PCI-endurance pellet, and the material containing the Mn-Al additive showed its creep performance of much better than UO2 material. The HANA cladding has been irradiated up to 61 MWD/kgU, and the results have shown that its oxidation resistance is better by 40% than that of Zircaloy. The 30 types of candidate materials for next generation have been developed through alloy design and property tests

Wavelength Selection For Laser Raman Spectroscopy of Putative Martian Habitats and Biomolecules

Science.gov (United States)

Wynn-Williams, D. D.; Newton, E. M. G.; Edwards, H. G. M.

Pigments are key potential biomarkers for any former life on Mars because of the selective pressure of solar radiation on any biological system that could have evolved at its surface. We have found that the near -Infrared laser Raman spectrometer available to use was eminently suitable for diagnostic analysis of pigments because of their minimal autofluorescence at its 1064 nm excitation wav elength. However, we have now evaluated a diverse range of excitation wavelengths to confirm this choice, to ensure that we have the best technique to seek for pigments and their derivatives from any former surface life on Mars. The Raman is weak relative to fluorescence, which results in elevated baseline and concurrent swamping of Raman bands. We confirm the molecular information available from near-IR FT Raman spectra for two highly pigmented UV-tolerant epilithic Antarctic lichens (Acarospora chlorop hana and Caloplaca saxicola) from Victoria Land, a whole endolithic microbial community and endolithic cyanobacterium Chroococcidiopsis from within translucent sandstone of the Trans -Antarctic Mountains, and the free- living cyanobacterium Nostoc commune from Alexander Island, Antarctic Peninsula region. We also show that much of the information we require on biomolecules is not evident from lasers of shorter wavelengths. A miniature 1064 nm Raman spectrometer with an In-Ga-As detector sensitive to IR is being developed by Montana State University (now existing as a prototype) as the prime instrument for a proposed UK-led Mars rover mission (Vanguard). Preliminary spectra from this system confirm the suitability of the near-IR laser.

A 4-year study of avian influenza virus prevalence and subtype diversity in ducks of Newfoundland, Canada.

Science.gov (United States)

Huang, Yanyan; Wille, Michelle; Dobbin, Ashley; Robertson, Gregory J; Ryan, Pierre; Ojkic, Davor; Whitney, Hugh; Lang, Andrew S

2013-10-01

The island of Newfoundland, Canada, is at the eastern edge of North America and has migratory bird connections with the continental mainland as well as across the North Atlantic Ocean. Here, we report a 4-year avian influenza virus (AIV) epidemiological study in ducks in the St. John's region of Newfoundland. The overall prevalence of AIV detection in ducks during this study was 7.2%, with American Black Ducks contributing the vast majority of the collected samples and the AIV positives. The juvenile ducks showed a significantly higher AIV detection rate (10.6%) compared with adults (3.4%). Seasonally, AIV prevalence rates were higher in the autumn (8.4%), but positives were still detected in the winter (4.6%). Preliminary serology tests showed a high incidence of previous AIV infection (20/38, 52.6%). A total of 43 viruses were characterized for their HA-NA or HA subtypes, which revealed a large diversity of AIV subtypes and little recurrence of subtypes from year to year. Investigation of the movement patterns of ducks in this region showed that it is a largely non-migratory duck population, which may contribute to the observed pattern of high AIV subtype turnover. Phylogenetic analysis of 4 H1N1 and one H5N4 AIVs showed these viruses were highly similar to other low pathogenic AIV sequences from waterfowl in North America and assigned all gene segments into American-avian clades. Notably, the H1N1 viruses, which were identified in consecutive years, possessed homologous genomes. Such detection of homologous AIV genomes across years is rare, but indicates the role of the environmental reservoir in viral perpetuation.

Regional patterns of genetic diversity in swine influenza A viruses in the United States from 2010 to 2016.

Science.gov (United States)

Walia, Rasna R; Anderson, Tavis K; Vincent, Amy L

2018-04-06

Regular spatial and temporal analyses of the genetic diversity and evolutionary patterns of influenza A virus (IAV) in swine informs control efforts and improves animal health. Initiated in 2009, the USDA passively surveils IAV in U.S. swine, with a focus on subtyping clinical respiratory submissions, sequencing at minimum the hemagglutinin (HA) and neuraminidase (NA) genes, and sharing these data publicly. In this study, our goal was to quantify and describe regional and national patterns in the genetic diversity and evolution of IAV in U.S. swine from 2010 to 2016. A comprehensive phylogenetic and epidemiological analysis of publicly available HA and NA genes generated by the USDA surveillance system collected from January 2010 to December 2016 was conducted. The dominant subtypes and genetic clades detected during the study period were H1N1 (H1-γ/1A.3.3.3, N1-classical, 29%), H1N2 (H1-δ1/1B.2.2, N2-2002, 27%), and H3N2 (H3-IV-A, N2-2002, 15%), but many other minor clades were also maintained. Year-round circulation was observed, with a primary epidemic peak in October-November and a secondary epidemic peak in March-April. Partitioning these data into 5 spatial zones revealed that genetic diversity varied regionally and was not correlated with aggregated national patterns of HA/NA diversity. These data suggest that vaccine composition and control efforts should consider IAV diversity within swine production regions in addition to aggregated national patterns. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Effects of Some Feed Suplements Types to the Growth of Javaen Barb/Brek Fish (Puntius orphoides Second Filial as Domestication Product

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Priyo Susatyo

2016-11-01

Full Text Available Aquaculture can be improved by a diversified approach in the form of domestication research  of a wild fish. The research has been done by cultivating Javaen Barb/Brek  (Puntius orphoides from Serayu river, Banyumas at a natural pond and laboratory scale. Brek fish is relative slow in growth and development of gonad. This research is aimed to determine: (1 the rate of general growth of Brek in the provision of some kinds of additional food; (2 Relative Growth Rate (RGR; (3 Specific Growth Rate (SGR and Feed Conversion (FC. The research used experimental methods. The method was a completely randomized design (CRD of 4 treatments and 3 replicationsof: A = 100% pellet; B = 70% soybean sprout and 30% pellet; C = 70% Ipomoea aquatica leaf and 30% pellet; D = 35% soybean sprouts, 35% I. aquatica leaf and 30% pellet. Quantitative data were analysed by analysis of variance (ANOVA of the fishes growth.The results show influence of feed types to the Relative Growth Rate (RGR of Javaean Barb. The best RGR with the value of 72.40 was given by feed types in the D combination. Meanwhile, Specific Growth Rate (SGR and Feed Conversion (FC were not affected  by the feed types. The study were expected to provide suggestions for efficient feeding techniques in attempts at domestication of wild fish.How to CiteSusatyo, P., Sugiharto, S., Hana, H., & Chasanah, T. (2016. Effects of Some Feed Suplements Types to The Growth of Javaen Barb/Brek Fish (Puntius orphoides Second Filial As Domestication Product. Biosaintifika: Journal of Biology & Biology Education, 8(3, 278-285. 

Nicoboxil/nonivamide cream effectively and safely reduces acute nonspecific low back pain – a randomized, placebo-controlled trial

Directory of Open Access Journals (Sweden)

Blahova Z

2016-12-01

Full Text Available Zuzana Blahova,1 Janina Claudia Holm,1 Thomas Weiser,2 Erika Richter,2 Matthias Trampisch,2 Elena Akarachkova3 1Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; 2Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim am Rhein, Germany; 3I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation Background/objective: Low back pain affects many patients and has a high socioeconomic impact. Topical capsaicinoids have been used for decades to treat musculoskeletal pain. This study investigated the effects of the fixed dose combination (FDC of nonivamide (a capsaicinoid and nicoboxil (a nicotinic acid ester cream in the treatment of acute nonspecific low back pain.Materials and methods: This phase III randomized, double-blind, placebo-controlled, multinational, multi-center trial investigated efficacy, safety, and tolerability of topical nicoboxil 1.08%/nonivamide 0.17% (Finalgon® cream in treatment of acute nonspecific low back pain with the endpoints: pain intensity (PI difference between pre-dose baseline and 8 hours after first application and the end of treatment, mobility score, and efficacy score.Results: Patients (n=138, 21–65 years of age, were treated for up to 4 days with FDC or placebo cream. Mean baseline PI was 6.8 on a 0–10 point numerical rating scale. After 8 hours, pain was more reduced with the FDC than with placebo (adjusted means: 2.824 vs. 0.975 points; p<0.0001. On the last treatment day, mean pain reduction by the FDC was stronger than with placebo (adjusted means: 5.132 vs. 2.174 points; p<0.0001. Mobility on Day 1 was in favor of the FDC when compared to placebo (odds ratio [95% confidence interval {CI}]: 7.200 [3.609, 14.363], p<0.0001. At the end of treatment, patients treated with the FDC rated efficacy significantly higher than placebo (odds ratio [95% CI]: 11.370 [5.342, 24.199], p<0.0001. Both treatments were tolerated well. No serious adverse events were reported.Conclusion: Nicoboxil

Quality of life in borderline patients comorbid with anxiety spectrum disorders – a cross-sectional study

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Grambal A

2016-08-01

Full Text Available Ales Grambal,1 Jan Prasko,1 Dana Kamaradova,1 Klara Latalova,1 Michaela Holubova,1,2 Zuzana Sedláčková,3 Radovan Hruby4 1Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital, Olomouc, 2Department of Psychiatry, Hospital Liberec, Liberec, 3Department of Psychology, Faculty of Arts, Palacky University Olomouc, Olomouc, Czech Republic; 4Private Practice, Martin, Slovak Republic Introduction: Borderline personality disorder (BPD significantly reduces the quality of life (QoL in mental, social, and work domains. Patients with BPD often suffer from depressive anxiety symptoms. The purpose of this cross-sectional study was to compare the QoL and demographic and clinical factors of inpatients diagnosed with BPD and comorbid anxiety spectrum disorders, and healthy controls.Methods: Ninety-two hospitalized patients treated in the psychotherapeutic department and 40 healthy controls were included. Subjects were assessed by the Quality of Life Satisfaction and Enjoyment Questionnaire (Q-LES-Q, Dissociative Experiences Scale, Beck Depression Inventory (BDI-II, Beck Anxiety Inventory, Clinical Global Impression, demographic questionnaire, Sheehan Disability Scale (SDS, and Sheehan Anxiety Scale.Results: BPD patients suffered from comorbid anxiety disorders, panic disorder (18.5%, social phobia (20.7%, generalized anxiety disorder/mixed anxiety depression disorder (17.4%, adjustment disorder (22.8%, and posttraumatic stress disorder (8.7%; 19.6% patients had two or more anxiety disorder comorbidities. Patients score in Q-LES-Q (general was 36.24±9.21, which was significantly lower in comparison to controls (57.83±10.21 and similar in all domains (physical health, feelings, work, household, school/study, leisure, social activities. The subjective level of depression measured by BDI and SDS (social life and family subscales negatively correlated with all Q-LES-Q domains.Conclusion: Patients suffering

Dissociative symptoms reflect levels of tumor necrosis factor alpha in patients with unipolar depression

Directory of Open Access Journals (Sweden)

Bizik G

2014-04-01

Full Text Available Gustav Bizik,1 Petr Bob,1 Jiri Raboch,1 Josef Pavlat,1 Jana Uhrova,2 Hana Benakova,2 Tomas Zima2 1Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry and UHSL, 2Department of Clinical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic Abstract: Recent evidence indicates that the nature of interactions between the nervous system and immune system is important in the pathogenesis of depression. Specifically, alterations in pro-inflammatory cytokines have been related to the development of several psychological and neurobiological manifestations of depressive disorder, as well as to stress exposure. A number of findings point to tumor necrosis factor alpha (TNF-α as one of the central factors in these processes. Accordingly, in the present study, we test the hypothesis that specific influences of chronic stressors related to traumatic stress and dissociation are related to alterations in TNF-α levels. We performed psychometric measurement of depression (Beck Depression Inventory [BDI]-II, traumatic stress symptoms (Trauma Symptom Checklist [TSC]-40, and psychological and somatoform dissociation (Dissociative Experiences Scale [DES] and Somatoform Dissociation Questionnaire [SDQ]-20, respectively, and immunochemical measure of serum TNF-α in 66 inpatients with unipolar depression (mean age 43.1 ± 7.3 years. The results show that TNF-α is significantly related to DES (Spearman R=−0.42, P<0.01, SDQ-20 (Spearman R=−0.38, P<0.01, and TSC-40 (Spearman R=−0.41, P<0.01, but not to BDI-II. Results of the present study suggest that TNF-α levels are related to dissociative symptoms and stress exposure in depressed patients. Keywords: depression, dissociation, TNF-alpha, traumatic stress

Final Report on Design, Fabrication and Test of HANARO Instrumented Capsule (07M-13N) for the Researches of Irradiation Performance of Parts of X-Gen Nuclear Fuel Assembly

Energy Technology Data Exchange (ETDEWEB)

Choo, K. N.; Kim, B. G.; Kang, Y. H. (and others)

2008-08-15

An instrumented capsule of 07M-13N was designed, fabricated and irradiated for an evaluation of the neutron irradiation properties of the parts of a X-Gen nuclear fuel assembly for PWR requested by KNF. Some specimens of control rod materials of AP1000 reactor requested by Westinghouse Co. were inserted in this capsule as a preliminary irradiation test and Polyimide specimens requested by Hanyang university were also inserted. 463 specimens such as buckling and spring test specimens of cell spacer grid, tensile, microstructure and tensile of welded parts, irradiation growth, spring test specimens made of HANA tube, Zirlo, Zircaloy-4, Inconel-718, Polyimide, Ag and Ag-In-Cd alloys were placed in the capsule. During the irradiation test, the temperature of the specimens and the thermal/fast neutron fluences were measured by 14 thermocouples and 7 sets of neutron fluence monitors installed in the capsule. A new friction welded tube between STS304 and Al1050 alloys was introduced in the capsule to prevent a coolant leakage into a capsule during a capsule cutting process in HANARO. The capsule was irradiated for 95.19 days (4 cycles) in the CT test hole of HANARO of a 30MW thermal output at 230 {approx} 420 .deg. C. The specimens were irradiated up to a maximum fast neutron fluence of 1.27x10{sup 21}(n/cm{sup 2}) (E>1.0MeV) and the dpa of the irradiated specimens were evaluated as 1.21 {approx} 1.97. The irradiated specimens were tested to evaluate the irradiation performance of the parts of an X-Gen fuel assembly in the IMEF hot cell and the obtained results will be very valuable for the related researches of the users.

A Full-Vector Geomagnetic PSV Curve Derived from East Maui Volcano Lava Flows for the Last ~15,000 years

Science.gov (United States)

Herrero-Bervera, E.; Hagstrum, J. T.; Champion, D. E.; Dekkers, M. J.; Bohnel, H.

2012-12-01

We have studied the paleomagnetism and rock magnetism of oriented samples from 105 lava flows erupted by the East Maui Volcano, Hawai`i, (i.e. Hana Volcanics) in order to construct a directional and absolute paleointensity (full-vector) paleosecular variation (PSV) curve for the last ~15,000 years. The directional geomagnetic behavior for East Maui has already been published by Sherrod et al. [JGR, 111, 10,1029/2005JB003876, 2006], and Herrero-Bervera and Valet [PEPI, 161-267-280, 2007]. All lava flows were previously dated using radiocarbon methods and span the last ~15,000 years of geomagnetic behavior. In addition to demagnetization experiments (i.e. alternating field and thermal) we have determined Curie temperatures and hysteresis parameters to characterize composition and grain size of the magnetic grains contained by the sampled flows. Accordingly, most lava flow samples have two types of magnetic minerals in different proportions; low-Ti titanomagnetite with high Curie temperature and high-Ti titanomagnetite with low Curie temperature. During sample heating and cooling the temperature curves are often irreversible. Magnetic grains have sizes that are within the pseudo single domain range and include both single and multi domain particles. Absolute paleointensities (PI) of 37 flows were obtained using the multi-specimen parallel differential pTRM method [Dekkers and Böhnel, EPSL, 248, 508-517, 2006], mostly at temperatures between 170° and 250°C when high-Ti titanomagnetite was dominant. In a few samples with magnetic grains having near-magnetite compositions, higher temperatures could be used. For some of the samples the recently proposed domain-state correction [Fabian and Leonhardt, EPSL, 297, 84-94, 2010] was applied as well. In addition, we have been able to successfully obtain PIs by means of the Thellier-Coe protocol for 17 lava flows. Our paleointensity results correlate well with global absolute paleointensity determinations.

SCHOOL COMMUNITY PERCEPTION OF LIBRARY APPS AGAINTS LIBRARY EMPOWERMENT

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Achmad Riyadi Alberto

2017-07-01

Full Text Available Abstract. This research is motivated by the development of information and communication technology (ICT in the library world so rapidly that allows libraries in the present to develop its services into digital-based services. This study aims to find out the school community’s perception of library apps developed by Riche Cynthia Johan, Hana Silvana, and Holin Sulistyo and its influence on library empowerment at the library of SD Laboratorium Percontohan UPI Bandung. Library apps in this research belong to the context of m-libraries, which is a library that meets the needs of its users by using mobile platforms such as smartphones,computers, and other mobile devices. Empowerment of library is the utilization of all aspects of the implementation of libraries to the best in order to achieve the expected goals. An analysis of the schoolcommunity’s perception of library apps using the Technology Acceptance Model (TAM includes: ease of use, usefulness, usability, usage trends, and real-use conditions. While the empowerment of the library includes aspects: information empowerment, empowerment of learning resources, empowerment of human resources, empowerment of library facilities, and library promotion. The research method used in this research is descriptive method with quantitative approach. Population and sample in this research is school community at SD Laboratorium Percontohan UPI Bandung. Determination of sample criteria by using disproportionate stratified random sampling with the number of samples of 83 respondents. Data analysis using simple linear regression to measure the influence of school community perception about library apps to library empowerment. The result of data analysis shows that there is influence between school community perception about library apps to library empowerment at library of SD Laboratorium Percontohan UPI Bandung which is proved by library acceptance level and library empowerment improvement.

Evaluation of a Ductility after High Temperature Oxidation with the Three-Point Bend Test in Zirconium Alloys

International Nuclear Information System (INIS)

Jung, Yang Il; Park, Sang Yoon; Park, Jeong Yong; Jeong, Yong Hwan

2010-01-01

In a light water reactor, the fuel cladding play an important role of preventing leakage of radioactive materials into the coolant, and thus the mechanical integrity of the cladding should be guaranteed under the conditions of normal and transient operation. In the case of a loss of coolant accident (LOCA), the cladding is subjected to a high temperature oxidation which is finally quenched because of an emergency coolant reflooding into the core. In this situation, the current LOCA criteria consist of five separate requirements: i) peak cladding temperature, ii) maximum cladding oxidation, iii) maximum hydrogen generation, iv) coolable geometry, and v) long-term cooling. The claddings lose their ductility due to the microstructural phase transformation from beta to martensite alpha-prime. and hydrogen up-take after LOCA. Since the reduction in ductility can induce embrittlement of claddings, post-quench ductility is one of the major concerns in transient operation circumstances. For the analysis, usually ring compression test are performed on ring samples cut from the tube to examine the oxidized cladding ductility. However, the test would not be applicable to the platelet samples which are general form of a specimen for developing alloys. As a high burn-up fuel cladding materials, Zircaloys are being replaced by modern zirconium alloys such as ZIRLO, and M5. Korea has also developed a new fuel cladding material HANA (high performance alloy for nuclear application) by the Korea Atomic Energy Research Institute. Because of the different composition of the newer claddings in comparison with the conventional Zircaloy-4, the high temperature oxidation behavior and the ductility after the oxidation would be different, and the properties should be evaluated how much the newer claddings were improved

Social Interaction Needs and Entertainment Approaches to Pregnancy Well-Being in mHealth Technology Design for Low-Income Transmigrant Women: Qualitative Codesign Study.

Science.gov (United States)

AlJaberi, Hana

2018-04-13

Low-income Caribbean transmigrant women face unique health challenges during pregnancy that set forth multidimensional implications for the design of mobile health (mHealth). Acknowledgment of the unique health needs of low-income Caribbean immigrant women in the United States and what that entails regarding technology design remains rarely examined in the literature of mHealth technologies. The goal of this study was to reveal the needs and gaps in mHealth interventions for pregnant immigrant women not yet realized in this field. These understandings reveal design opportunities for mHealth. The use of the qualitative participatory action research approach of codesign workshops in this study resulted in design solutions by the participants after reflecting on their earlier focus group discussions. The highlights are not the resulting designs per se but rather the inferences derived from the researcher reflecting on these designs. The designs exposed two themes relevant to this paper. First, the participants desired the inclusion and rebuilding of social and organizational relationships in mHealth. The resulting designs formulate an understanding of the women's health-related social support needs and how technology can facilitate them. Second, the participants wanted entertainment with an element of social participation incorporated in mHealth pregnancy management interventions. This brings attention to the role entertainment can add to the impact mHealth can deliver for pregnancy well-being. The study concluded with an examination of social and entertainment design implications that reveal pregnant immigrant women's virtual health-related sharing habits, choice of sharing interaction scenarios during pregnancy (eg, local, long distance, one-way, two-way, and many-many), and choice of sharing media (eg, text, voice, and video). Additionally, the study revealed exclusions to social sharing capabilities in health technologies for these women. ©Hana Al

Individual correlates of self-stigma in patients with anxiety disorders with and without comorbidities

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Ociskova M

2015-07-01

Full Text Available Marie Ociskova,1,2 Jan Prasko,1 Dana Kamaradova,1 Ales Grambal,1 Zuzana Sigmundova1 1Department of Psychiatry, University Hospital in Olomouc, Faculty of Medicine and Dentistry, 2Department of Psychology, Faculty of Arts, Palacky University in Olomouc, Olomouc, Czech Republic Background: A number of psychiatric patients experience stigma connected to prejudices about mental disorders. It has been shown that stigma is most harmful when it is internalized. Most of the studies were performed on individuals either with psychoses or with mood disorders, and hence, there are almost no studies with other diagnostic categories. The goals of this research were to identify factors that are significantly related to self-stigma in patients with anxiety disorders and to suggest possible models of causality for these relationships.Methods: A total of 109 patients with anxiety disorders and possible comorbid depressive or personality disorders, who were admitted to the psychotherapeutic department participated in this study. All patients completed several psychodiagnostic methods, ie, the Internalized Stigma of Mental Illness Scale, Temperament and Character Inventory-Revised Version, Adult Dispositional Hope Scale, Dissociative Experiences Scale, Beck Anxiety Inventory, Beck Depression Inventory-Second Edition, and Clinical Global Impression (also completed by the senior psychiatrist.Results: The overall level of self-stigma was positively associated with a comorbid personality disorder, more severe symptomatology, more intense symptoms of anxiety and depression, and higher levels of dissociation and harm avoidance. Self-stigma was negatively related to hope, reward dependence, persistence, self-directedness, and cooperativeness. Multiple regression analysis showed that the most significant factors connected to self-stigma are harm avoidance, the intensity of depressive symptoms, and self-directedness. Two models of causality were proposed and validated. It

A point mutation in the polymerase protein PB2 allows a reassortant H9N2 influenza isolate of wild-bird origin to replicate in human cells.

Science.gov (United States)

Hussein, Islam T.M.; Ma, Eric J.; Meixell, Brandt; Hill, Nichola J.; Lindberg, Mark S.; Albrecht , Randy A.; Bahl, Justin; Runstadler, Jonathan A.

2016-01-01

H9N2 influenza A viruses are on the list of potentially pandemic subtypes. Therefore, it is important to understand how genomic reassortment and genetic polymorphisms affect phenotypes of H9N2 viruses circulating in the wild bird reservoir. A comparative genetic analysis of North American H9N2 isolates of wild bird origin identified a naturally occurring reassortant virus containing gene segments derived from both North American and Eurasian lineage ancestors. The PB2 segment of this virus encodes 10 amino acid changes that distinguish it from other H9 strains circulating in North America. G590S, one of the 10 amino acid substitutions observed, was present in ~ 12% of H9 viruses worldwide. This mutation combined with R591 has been reported as a marker of pathogenicity for human pandemic 2009 H1N1 viruses. Screening by polymerase reporter assay of all the natural polymorphisms at these two positions identified G590/K591 and S590/K591 as the most active, with the highest polymerase activity recorded for the SK polymorphism. Rescued viruses containing these two polymorphic combinations replicated more efficiently in MDCK cells and they were the only ones tested that were capable of establishing productive infection in NHBE cells. A global analysis of all PB2 sequences identified the K591 signature in six viral HA/NA subtypes isolated from several hosts in seven geographic locations. Interestingly, introducing the K591 mutation into the PB2 of a human-adapted H3N2 virus did not affect its polymerase activity. Our findings demonstrate that a single point mutation in the PB2 of a low pathogenic H9N2 isolate could have a significant effect on viral phenotype and increase its propensity to infect mammals. However, this effect is not universal, warranting caution in interpreting point mutations without considering protein sequence context.

Attention deficit hyperactivity disorder and disordered eating behaviors: links, risks, and challenges faced

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Ptacek R

2016-03-01

Full Text Available Radek Ptacek,1,2 George B Stefano,1,3 Simon Weissenberger,1 Devang Akotia,1 Jiri Raboch,1 Hana Papezova,1 Lucie Domkarova,1 Tereza Stepankova,1 Michal Goetz4 1Department of Psychiatry, Charles University 1st Medical Faculty and General Teaching Hospital, Prague, Czech Republic; 2Department of Psychology, University of New York in Prague, Prague, Czech Republic; 3MitoGenetics Research Institute, MitoGenetics, LLC, Farmingdale, NY, USA; 4Department of Child Psychiatry, Charles University Second Faculty of Medicine, University Hospital Motol, Prague, Czech Republic Abstract: Attention deficit hyperactivity disorder (ADHD is a neurodevelopmental disorder that often persists in adulthood. It is defined by inattention and/or hyperactivity–impulsivity. ADHD is associated with many comorbidities, including eating disorders (EDs. In the last decade, studies have reported that ADHD is linked with binge EDs, bulimia nervosa, and anorexia nervosa. Many postulates have been proposed to explain the association: 1 impulsive behavior in ADHD patients leads to disordered eating behavior; 2 other psychologic comorbidities present in ADHD patients account for eating behavior; 3 poor eating habits and resulting nutritional deficiencies contribute to ADHD symptoms; and 4 other risk factors common to both ADHD and EDs contribute to the coincidence of both diseases. Additionally, sex differences become a significant issue in the discussion of EDs and ADHD because of the higher incidence of bulimia nervosa and anorexia nervosa in females and the ability of females to mask the symptoms of ADHD. Interestingly, both EDs and ADHD rely on a common neural substrate, namely, dopaminergic signaling. Dopaminergic signaling is critical for motor activity and emotion, the latter enabling the former into a combined motivated movement like eating. This linkage aids in explaining the many comorbidities associated with ADHD. The interconnection of ADHD and EDs is discussed from

Full Vector Studies of the Last 10 Thousand Years Derived From The East Maui Volcano Hawaii

Science.gov (United States)

Herrero-Bervera, E.; Dekkers, M. J.; Bohnel, H.; Hagstrum, J. T.; Champion, D. E.

2010-12-01

We have determined the paleointensity of nine lavas flows that recorded the last 10 kyrs of geomagnetic field behavior from the youngest and largest of the two edifices of the island of Maui (i.e. Hana Volcanics, East Maui) with the multispecimen parallel differential pTRM method [Dekkers and Böhnel, EPSL, 248, 508-517, 2006]. The flows are characterized by irreversible Curie curves indicating two kinds of magnetic carriers: one almost pure magnetite and the second one Ti-rich magnetite with possible traces of titanomaghemite. The coercivity of remanence (Hcr) suggests that low-coercivity grains carry the NRM. Magnetic minerals from all of these flows are scattered within the PSD range with the exception of site HKAM (age 4.07±+0.09 ka) that lies in the SD range. The multispecimen method involves giving a laboratory pTRM to pristine specimens in different field strengths parallel to the original TRM; note that all pTRMs are given within the same range. From an existing sample collection for paleosecular variation studies [Herrero-Bervera and Valet, PEPI, 161, 267-280, 2007] we processed samples from 9 flows for paleointensity determinations ranging in age from 0.830.06 ka to 8.19±0.06 ka. pTRMs were given by in-field heating and cooling from 175 and to 260°C to avoid alteration. Low-field susceptibility variation appeared to be less than 10%, and sample sets from a few flows were heated to two different temperatures to check for consistency of results. All flows yielded good quality data. The paleointensity values increase to ~46 microTesla at ~ 2.2 ka and drop to ~22 microTesla at ~3.5 ka. At ~8.2 ka, ~39 microTesla is obtained, i.e. slightly higher than the present-day value (36 microTesla). Our paleointensity results (at least 7 flows) correlate well with the absolute paleointensity global determinations. The influence of a recently proposed domain-state correction [Fabian and Leonhardt, 2010, EPSL] on the paleointensity values will be investigated and shown.

The Big Data Tools Impact on Development of Simulation-Concerned Academic Disciplines

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A. A. Sukhobokov

2015-01-01

Full Text Available The article gives a definition of Big Data on the basis of 5V (Volume, Variety, Velocity, Veracity, Value as well as shows examples of tasks that require using Big Data tools in a diversity of areas, namely: health, education, financial services, industry, agriculture, logistics, retail, information technology, telecommunications and others. An overview of Big Data tools is delivered, including open source products, IBM Bluemix and SAP HANA platforms. Examples of architecture of corporate data processing and management systems using Big Data tools are shown for big Internet companies and for enterprises in traditional industries. Within the overview, a classification of Big Data tools is proposed that fills gaps of previously developed similar classifications. The new classification contains 19 classes and allows embracing several hundreds of existing and emerging products.The uprise and use of Big Data tools, in addition to solving practical problems, affects the development of scientific disciplines concerning the simulation of technical, natural or socioeconomic systems and the solution of practical problems based on developed models. New schools arise in these disciplines. These new schools decide peculiar to each discipline tasks, but for systems with a much bigger number of internal elements and connections between them. Characteristics of the problems to be solved under new schools, not always meet the criteria for Big Data. It is suggested to identify the Big Data as a part of the theory of sorting and searching algorithms. In other disciplines the new schools are called by analogy with Big Data: Big Calculation in numerical methods, Big Simulation in imitational modeling, Big Management in the management of socio-economic systems, Big Optimal Control in the optimal control theory. The paper shows examples of tasks and methods to be developed within new schools. The educed tendency is not limited to the considered disciplines: there are

Blood Profile of Rabbits Infected with Eimeria magna

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A Hana

2011-09-01

Full Text Available Abstract. The research aimed at determining the blood profile of local rabbits infected with different dose of Eimeria magna oocysts. This research used 45 male rabbits with the age of 4 month old, range from 1.5 to 1.8 kg, clinically healthy and free from coccidiosis. The rabbits were randomly divided into 3 groups, group I as control (K-0 was given 1.0 ml distilled water/rabbit orally, group II (K-10 was infected with single dose of 10x106 oocysts of E. magna/rabbit orally, and group III (K-20 was infected with single dose of 20x106 oocysts of E. magna/rabbit orally. After infection, rabbits were examined for clinical signs, body weight and temperature daily for five days. Blood samples were drawn from the vena marginalis to examine the number of erythrocytes, hemoglobine, packed cell volume (PCV, leukocytes and its deferent, total protein plasma (TPP and fibrinogen, activities of alkaline phosphatase (ALP, alanine amino transferase (ALT, and aspartat aminotransferase (AST. The data were statistically analyzed by two-way anova using factorial design. The results of this research showed that the infection of E. magna in rabbits caused fever and weight loss, accompanied by normochromic microcytic anemia (at doses of 10x106 oocysts, macrocytic normochromic (at doses of 20x106 oocysts, leukocytosis, lymphocytosis, hiperfibrinogenemia, and increased of ALP activity. There were correlations between clinical symptoms and blood profile of rabbits infected with E. magna for five days. The higher the dose and the longer the infection of E. magna in rabbits caused weight loss, increased body temperature, MCV (microcytic to macrocytic, leukocyte, fibrinogen and ALP activity. These findings were useful to have a better understanding of pathophysiology of E. magna infection in  rabbits. Key Words: Eimeria magna, oocyst, rabbit, blood profile A Hana et al/Animal Production 13(3:185-190 (2011

Inappropriate pharmacological treatment in older adults affected by cardiovascular disease and other chronic comorbidities: a systematic literature review to identify potentially inappropriate prescription indicators

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Lucenteforte E

2017-10-01

Full Text Available Ersilia Lucenteforte,1 Niccolò Lombardi,1,* Davide Liborio Vetrano,2,* Domenico La Carpia,2,* Zuzana Mitrova,3 Ursula Kirchmayer,3 Giovanni Corrao,4 Francesco Lapi,5 Alessandro Mugelli,1 Alfredo Vannacci1 On behalf of the Italian Group for Appropriate Drug prescription in the Elderly (I-GrADE 1Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA, University of Florence, Florence, Italy; 2Department of Geriatrics Catholic University, Rome, Italy; 3Department of Epidemiology, ASL 1 Rome, Italy; 4Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy; 5Epidemiology Unit, ARS Toscana, Florence, Italy *These authors contributed equally to this work Abstract: Avoiding medications in which the risks outweigh the benefits in the elderly patient is a challenge for physicians, and different criteria to identify inappropriate prescription (IP exist to aid prescribers. Definition of IP indicators in the Italian geriatric population affected by cardiovascular disease and chronic comorbidities could be extremely useful for prescribers and could offer advantages from a public health perspective. The purpose of the present study was to identify IP indicators by means of a systematic literature review coupled with consensus criteria. A systematic search of PubMed, EMBASE, and CENTRAL databases was conducted, with the search structured around four themes and combining each with the Boolean operator “and”. The first regarded “prescriptions”, the second “adverse events”, the third “cardiovascular conditions”, and the last was planned to identify studies on “older people”. Two investigators independently reviewed titles, abstracts, full texts, and selected articles addressing IP in the elderly affected by cardiovascular condition using the following inclusion criteria: studies on people aged ≥65 years; studies on patients with no restriction on age but with data on subjects

Envisioning the Shôjo Aesthetic in Illustrations of Miyazawa Kenji’s Literature.

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Helen Claire Kilpatrick

2013-01-01

Full Text Available Despite an ever-growing body of scholarship on the shôjo (girl in manga and anime, little has been written about representations of the ‘girl’ in Japanese picture books. Shôjo literature and culture have grown exponentially in Japan since about the 1980s, but there has been a tendency in popular media to overemphasise the 'cute', disempowering aspects of the ‘girl’. By using Takahara Eiri's (1999 concept of “girl consciousness” and Honda Masuko's (1992 envisioning of the girl’s imagined freedom through a hirahira (fluttering aesthetic, notions of the powerless or mindlessly consuming shôjo can be dispelled. Such concepts help demonstrate that the girl ‘has her own creative, critical and cultural, if not social or political, power’ (Aoyama 2008: 286. This paper examines the shôjo tropes in contemporary illustrations that were produced to accompany two tales by the renowned author Miyazawa Kenji (1896-1933, Futago no Hoshi (Twin Stars and Ginga Tetsudô no Yoru (Night of the Milky Way Railway. Although Kenji (as he is known is not generally considered a shôjo author, some of his works incorporate gently transgressive shôjo themes reminiscent of, for example, Yoshiya Nobuko’s Hana Monogatari (Flower Tales from the 1920s. I argue that the current artwork of two award-winning artists, Makino Suzuko and Azuma Itsuko, reflects and enhances Kenji’s ‘girlish’ verbal images, bringing them to the fore in their accompanying imagery for Futago and Ginga by drawing on shôjo art, manga and literature. The artists thus bring into play intertextual references that occur not only across different historical temporalities but also through relations between the author, the artist, the text(s, the protagonists and the reading/viewing audience. The analysis of their striking artwork shows how they bring Kenji’s 1920s’ works firmly into the arena of the contemporary ‘girl’, expanding the abstract consciousness of the shôjo to

Water utilization of vegetables grown under plastic greenhouse conditions in Ankara using neutron probe technique

International Nuclear Information System (INIS)

Halitligil, M.B.; Kislal, H.; Sirin, H.; Sirin, C.; Kilicaslan, A.

2004-01-01

In order to find suitable varieties of tomato, pepper and cucumber for plastic greenhouse conditions in Ankara and ensure both higher yields and lower NO 3 leaching greenhouse experiments were conducted for three years. In the first year (2001) of the experiment four different varieties from each vegetable, namely, Tomato (Ecem F 1 , 9920 F 1 , 2116 F 1 and Yazg1 F 1 ), Cucumber (Hizir F 1 , Rapido, Hana, and Luna) and Pepper (1245 F 1 , 730 F 1 , Serademre 8 and 710 F 1 ) had been grown in the plastic greenhouse using drip irrigation-fertilization system. Yazg1 F 1 variety for tomato, Hizir F 1 variety for cucumber and Serademre 8 variety for pepper were chosen to be suitable varieties to grow in the plastic greenhouse conditions in Ankara. One access tube in each N 3 and N 0 treatment plots of tomato, cucumber and pepper in 2002 and 2003 experiments were installed for the soil moisture determinations at 30, 60 and 90 cm depths. Readings with the neutron probe were taken before planting and after harvest for the water consumption calculations using the water balance approach and the WUE was calculated on the basis of the ratio of dry matter weight to the amount of water consumed. Tensiometer and suction cups were installed at 15, 30, 45 and 60 cm depths only to N 1 , N 2 and N 3 treatments plots of each vegetable in 2002 and 2003. Tensiometer readings were taken just before irrigation. Also, soil solution samples from suction cups were taken at final harvest and NO 3 determinations were done with RQFLEX nitrate test strips. Significantly higher yields and WUE values were obtained when the same amount of N fertilizer is applied through fertigation compared to the treatment where N fertilizer applied to the soil then drip irrigated. The nitrate concentrations of the soil solution increased as the N rates increased and no NO 3 had been found in the soil solution taken from 75 cm soil depth, indicating that no leaching of N fertilizer occurred beyond 75 cm soil depth

Water utilization of vegetables grown under plastic greenhouse conditions in Ankara using neutron probe technique

International Nuclear Information System (INIS)

Halitligil, M.B.; Kislal, H.; Sirin, H.; Sirin, C.; Kilicaslan, A.

2004-01-01

Full text: In order to find suitable varieties of tomato, pepper and cucumber for plastic greenhouse conditions in Ankara and ensure both higher yields and lower NO 3 leaching greenhouse experiments were conducted for three years. In the first year (2001) of the experiment four different varieties from each vegetable, namely, Tomato (Ecem F 1 , 9920 F 1 , 2116 F 1 and Yazg1 F 1 ), Cucumber (Hizir F 1 , Rapido, Hana, and Luna) and Pepper (1245 F 1 , 730 F 1 , Serademre 8 and 710 F 1 ) had been grown in the plastic greenhouse using drip irrigation-fertiligation system. Yazg1 F 1 variety for tomato, Hizir F 1 variety for cucumber and Serademre 8 variety for pepper were chosen to be suitable varieties to grow in the plastic greenhouse conditions in Ankara. One access tube in each N 3 and N 0 treatment plots of tomato, cucumber and pepper in 2002 and 2003 experiments were installed for the soil moisture determinations at 30, 60 and 90 cm depths. Readings with the neutron probe were taken before planting and after harvest for the water consumption calculations using the water balance approach and the WUE was calculated on the basis of the ratio of dry matter weight to the amount of water consumed. Tensiometer and suction cups were installed at 15, 30, 45 and 60 cm depths only to N 1 , N 2 and N 3 treatments plots of each vegetable in 2002 and 2003. Tensiometer readings were taken just before irrigation. Also, soil solution samples from suction cups were taken at final harvest and NO 3 determinations were done with RQFLEX nitrate test strips. Significantly higher yields and WUE values were obtained when the same amount of N fertilizer is applied through fertigation compared to the treatment where N fertilizer applied to the soil then drip irrigated. The nitrate concentrations of the soil solution increased as the N rates increased and no NO 3 had been found in the soil solution taken from 75 cm soil depth, indicating that no leaching of N fertilizer occurred beyond 75 cm

Validity and interpretation of spirometric recordings to diagnose COPD in UK primary care

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Rothnie KJ

2017-06-01

Full Text Available Kieran J Rothnie,1,2 Joht S Chandan,3,4 Harry G Goss,4,5 Hana Müllerová,6 Jennifer K Quint1,2 1Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, 2Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, 3Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham, Birmingham, 4Medical School, Faculty of Medical Sciences, University College London, 5Jersey General Hospital, St Helier, Jersey, 6Respiratory Epidemiology, GlaxoSmithKline R&D, Uxbridge, UK Background: The diagnosis of COPD is dependent upon clinical judgment and confirmation of the presence of airflow obstruction using spirometry. Spirometry is now routinely available; however, spirometry incorrectly performed or interpreted can lead to misdiagnosis. We aimed to determine whether spirometry undertaken in primary care for patients suspected to have COPD was of sufficient quality and whether their spirometry was correctly interpreted.Methods: Two chest physicians re-read all spirometric readings for both quality of the procedure and interpretation, received as a part of COPD validation studies using data from the Clinical Practice Research Datalink (CPRD. We then used logistic regression to investigate predictors of correct interpretation.Results: Spirometry traces were obtained for 306 patients, of which 221 (72.2% were conducted in primary care. Of those conducted in primary care, 98.6% (n=218 of spirometry traces were of adequate quality. Of those traces that were of adequate quality and conducted in primary care, and in whom a general practitioner (GP diagnosis of COPD had been made, 72.5% (n=218 were consistent with obstruction. Historical records for asthma diagnosis significantly decreased odds of correct interpretation.Conclusion: The quality of the spirometry procedure undertaken in primary care is high. However, this was not reflected in the

MRI-guided stereotactic amygdalohippocampectomy: a single center experience

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Vojtěch Z

2015-02-01

Full Text Available Zdenek Vojtěch,1 Hana Malíková,2 Lenka Krámská,3 Roman Liščák,4 Vilibald Vladyka41Department of Neurology, 2Department of Radiodiagnostics, 3Department of Psychology, 4Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech RepublicBackground: This paper presents our experience of stereotactic radiofrequency amygdalohippocampectomy performed for intractable mesial temporal lobe epilepsy.Methods: The article describes the cases of 61 patients who were treated during the period from 2004 to 2010. Mean postoperative follow-up was 5.3 years. Neuropsychological results were obtained for a subset of 31 patients.Results: At their last postsurgical visit, 43 (70.5% patients were Engel class I, six (9.8% class II, nine (14.8% class III, and three (4.9% class IV. The surgery was complicated by four intracranial hematomas. One of them caused acute hydrocephalus and was treated by shunting and resolved without sequelae, while another caused transitory aphasia. The remaining hematomas were asymptomatic. There were two cases of meningitis which required antibiotic treatment. One patient committed suicide due to postoperative depression. After the procedure, we performed open epilepsy surgery and rethermolesions in three and two patients, respectively (8.2%. Patients showed increases in their mean full scale, verbal, and performance intelligence quotient (IQ scores of 4, 3, and 4 IQ points, respectively (P<0.05. Five (17.2%, four (13.8%, and four (13.3% patients improved their full scale, verbal, and performance IQ scores, respectively. No significant changes were found in memory performance, with a mean increase of 1, 3, and 0 memory quotient points in global, verbal, and visual memory, respectively (P<0.05. Global memory improved in three (10.3% patients, verbal memory in one (3.4%, and one patient (3.3% showed deterioration in visual memory.Conclusion: Stereotactic radiofrequency amygdalohippocampectomy offers a

Randomized controlled trials and real-world observational studies in evaluating cardiovascular safety of inhaled bronchodilator therapy in COPD

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Kardos P

2016-11-01

Full Text Available Peter Kardos,1 Sally Worsley,2 Dave Singh,3 Miguel Román-Rodríguez,4 David E Newby,5 Hana Müllerová2 1Group Practice and Respiratory, Allergy and Sleep Unit, Red Cross Maingau Hospital, Frankfurt, Germany; 2GSK, Stockley Park, Middlesex, 3University of Manchester, Medicines Evaluation Unit, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK; 4Primary Care Respiratory Research Unit, Instituto de Investigación Sanitaria de Palma IdisPa, Palma de Mallorca, Spain; 5BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK Abstract: Long-acting muscarinic antagonist (LAMA or long-acting β2-agonist (LABA bronchodilators and their combination are recommended for the maintenance treatment of chronic obstructive pulmonary disease (COPD. Although the efficacy of LAMAs and LABAs has been well established through randomized controlled trials (RCTs, questions remain regarding their cardiovascular (CV safety. Furthermore, while the safety of LAMA and LABA monotherapy has been extensively studied, data are lacking for LAMA/LABA combination therapy, and the majority of the studies that have reported on the CV safety of LAMA/LABA combination therapy were not specifically designed to assess this. Evaluation of CV safety for COPD treatments is important because many patients with COPD have underlying CV comorbidities. However, severe CV and other comorbidities are often exclusion criteria for RCTs, contributing to a lack in external validity and generalizability. Real-world observational studies are another important tool to evaluate the effectiveness and safety of COPD therapies in a broader population of patients and can improve upon the external validity limitations of RCTs. We examine what is already known regarding the CV and cerebrovascular safety of LAMA/LABA combination therapy from RCTs and real-world observational studies, and explore the advantages and

Spontaneous release of epiretinal membrane in a young weight-lifting athlete by presumed central rupture and centrifugal pull

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Mansour AM

2014-11-01

Full Text Available Ahmad M Mansour,1,2 Hana A Mansour,3 J Fernando Arevalo4,5 1Department of Ophthalmology, Rafic Hariri University Hospital, Beirut, Lebanon; 2Department of Ophthalmology, American University of Beirut, Beirut, Lebanon; 3Department of Biology, American University of Beirut, Beirut, Lebanon; 4Retina Department, The King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia; 5Retina Department, Wilmer Eye Institute, The Johns Hopkins University, Baltimore, MD, USA Abstract: This patient presented for surgery at the age of 32 years, 14 months after his initial complaint of metamorphopsia and visual loss in the right eye. Past tests demonstrated a whitish epiretinal membrane (ERM with translucent stress lines over a thickened macula. Visual acuity was found on last presentation to be normal with minimal alteration on Amsler grid testing. A torn ERM was found in the center with left-over ERM temporally and rolled-over ERM nasally at the site of the epicenter with no posterior vitreous detachment. Visual recovery occurred gradually over several days 2 months prior to presentation apparently following heavy weight-lifting with a sensation of severe eye pressure. Sequential funduscopy and optical coherence tomography scans demonstrated the peeling of an ERM accompanied by normalization of foveal thickness. Valsalva maneuver had put excessive tension on ERM which tore in its center at the weakest line with gradual contraction of the ERM away from the fovea towards the peripapillary area. This is a new mechanism of self-separation of ERM induced by Valsalva. ERM in young subjects is subject to rupture and subsequent separation by tangential traction. There are three mechanisms for spontaneous separation of ERM: 1 posterior vitreous detachment with pulling of ERM by detaching vitreous (most common in adults; 2 the contracting forces of the immature ERM become stronger than its adhesions to the retina resulting in slow tangential traction on the

Validation of asthma recording in electronic health records: a systematic review

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Nissen F

2017-12-01

Full Text Available Francis Nissen,1 Jennifer K Quint,2 Samantha Wilkinson,1 Hana Mullerova,3 Liam Smeeth,1 Ian J Douglas1 1Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK; 2National Heart and Lung Institute, Imperial College, London, UK; 3RWD & Epidemiology, GSK R&D, Uxbridge, UK Objective: To describe the methods used to validate asthma diagnoses in electronic health records and summarize the results of the validation studies. Background: Electronic health records are increasingly being used for research on asthma to inform health services and health policy. Validation of the recording of asthma diagnoses in electronic health records is essential to use these databases for credible epidemiological asthma research.Methods: We searched EMBASE and MEDLINE databases for studies that validated asthma diagnoses detected in electronic health records up to October 2016. Two reviewers independently assessed the full text against the predetermined inclusion criteria. Key data including author, year, data source, case definitions, reference standard, and validation statistics (including sensitivity, specificity, positive predictive value [PPV], and negative predictive value [NPV] were summarized in two tables.Results: Thirteen studies met the inclusion criteria. Most studies demonstrated a high validity using at least one case definition (PPV >80%. Ten studies used a manual validation as the reference standard; each had at least one case definition with a PPV of at least 63%, up to 100%. We also found two studies using a second independent database to validate asthma diagnoses. The PPVs of the best performing case definitions ranged from 46% to 58%. We found one study which used a questionnaire as the reference standard to validate a database case definition; the PPV of the case definition algorithm in this study was 89%. Conclusion: Attaining high PPVs (>80% is possible using each of the discussed validation

Building a network of flowers, green, and ocean. Investigation report on establishment of new energy vision in Wada Town area (Chiba Prefecture); Hana midori umi no network zukuri. Wadacho chiiki shin energy vision sakutei chosa hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-02-01

With the idea of living together with well-blessed nature placed as the base of building the town, new energy utilization promoting measures were established spanning over ten years starting fiscal 2000. Specifically, the vision was established with the following points as the substance: introduction of new energy technologies into the agricultural and fishery industries as the basic district industry, initiative introduction into public facilities in consideration of repercussion effects brought about by the introduction, provision of energy related information by improving publicity magazines and information technologies, and expanded provision of environmental information collaborated with schools. Specific measures discussed include photovoltaic power generation, utilization of bio-mass energies made available from livestock excreta, and algae, utilization of hydro-energy through the improvement project of the Komukai dam, utilization of wind power energy and ocean wave power energy, and utilization of rape-seed oil as automotive fuel. Such educational activities will also be promoted actively as the setting of economy indexes, assistance to autonomous activities, and holding training meetings, seminars, and experience education class rooms. (NEDO)

Impact of dissociation on treatment of depressive and anxiety spectrum disorders with and without personality disorders

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Prasko J

2016-10-01

Full Text Available Jan Prasko,1 Ales Grambal,1 Petra Kasalova,1 Dana Kamardova,1 Marie Ociskova,1 Michaela Holubova,1,2 Kristyna Vrbova,1 Zuzana Sigmundova,1 Klara Latalova,1 Milos Slepecky,3 Marta Zatkova3 1Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University in Olomouc, University Hospital Olomouc, Olomouc, 2Psychiatric Department, Hospital Liberec, Liberec, Czech Republic; 3Department of Psychology Sciences, Faculty of Social Science and Health Care, Constantine the Philosopher University in Nitra, Nitra, Slovak Republic Objective: The central goal of the study was to analyze the impact of dissociation on the treatment effectiveness in patients with anxiety/neurotic spectrum and depressive disorders with or without comorbid personality disorders.Methods: The research sample consisted of inpatients who were hospitalized in the psychiatric department and met the ICD-10 criteria for diagnosis of depressive disorder, panic disorder, generalized anxiety disorder, mixed anxiety–depressive disorder, agoraphobia, social phobia, obsessive compulsive disorder, posttraumatic stress disorder, adjustment disorders, dissociative/conversion disorders, somatoform disorder, or other anxiety/neurotic spectrum disorder. The participants completed these measures at the start and end of the therapeutic program – Beck Depression Inventory, Beck Anxiety Inventory, a subjective version of Clinical Global Impression-Severity, Sheehan Patient-Related Anxiety Scale, and Dissociative Experience Scale.Results: A total of 840 patients with anxiety or depressive spectrum disorders, who were resistant to pharmacological treatment on an outpatient basis and were referred for hospitalization for the 6-week complex therapeutic program, were enrolled in this study. Of them, 606 were statistically analyzed. Data from the remaining 234 (27.86% patients were not used because of various reasons (103 prematurely finished the program, 131 did not fill in most of the

Age at diagnosis of autism spectrum disorders: is there an association with socioeconomic status and family self-education about autism?

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Hrdlicka M

2016-07-01

Full Text Available Michal Hrdlicka,1 Maria Vacova,1 Hana Oslejskova,2 Veronika Gondzova,2 Iveta Vadlejchova,3 Jana Kocourkova,1 Jiri Koutek,1 Iva Dudova1 1Department of Child Psychiatry, Charles University Second Faculty of Medicine and University Hospital Motol, Prague, 2Department of Child Neurology, Masaryk University Faculty of Medicine and University Hospital, Brno, 3Child Psychiatry Clinic, Chomutov, Czech Republic Background: The marked increase in autism spectrum disorders (ASD prevalence has stimulated worldwide interest in exploring broader circumstances of care of autistic children, including the role of socioeconomic status (SES and family information on autism.Methods: Our sample comprised of 160 children who participated in a diagnostic examination focused on autism, and their parents who completed a simple descriptive questionnaire focusing on the family situation as well as family self-education about autism. The diagnosis of ASD was confirmed in 120 children (75% of the sample; 94 boys, 26 girls with mean age 6.2±2.7 years (median 5.3, range 2.2–17.2 years. In 71 autistic patients (59.2%, a diagnosis of mental retardation was also established.Results: The age at diagnosis of ASD correlated negatively with maternal (P=0.014 and paternal (P=0.002 ages at the time of birth of the ASD child as well as with paternal (P=0.002 and maternal (P=0.050 education. The age at diagnosis of ASD did not correlate with family SES. Mothers were significantly more active in seeking information on autism than fathers or both parents equally (80 vs 9 vs 28 cases, respectively; P<0.001. The mean number of information sources on autism was 3.5±1.8 with a range 0–9. The mean number of resources did not differ among the three SES groups (3.50 vs 3.49 vs 4.25, respectively; P=0.704. The mean number of sources did not correlate with the age at diagnosis of ASD. The most often used sources were the Internet (81.7%, followed by psychologists (48.3%, books (46.7%, and

Identifikace role produktového manažera a vytvoření standardní typové pozice Produktový manažer

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Zuzana Wroblowská

2013-10-01

Full Text Available The purpose of the article: Is to clarify the profile role of a product manager in present entrepreneurial routine in the Czech Republic. It is said about the Product Manager that he is a product evangelist, responsible for managing full product lifecycles of their products, while ensuring accurate schedules, product features, and making sure that product benefits are communicated to business partners and customers. The author’s objective was to provide a look insight in to a realistic picture of product managers’ job as well as to describe the skills, education, experience and attributes required for the product management position. Methodology/methods: To deal with this issue the interdisciplinary approach was best to apply, because theoretical resources and current state analysis of the topic as well as tendencies in its development required research in several disciplines. For secondary data mainly descriptive or analysis/synthesis approach for examining available resources were used. For succeeding empiric research both qualitative content analysis and quantitative methodology were used. The author carried out a two-phase research project. Texts in 100 unique recruitment advertisements were studying in the first phase of the research. Data gathering was running by personal questioning in the Czech companies in the second phase of the project. Scientific aim: The article is based on the conclusions of the doctoral thesis of RNDr. Zuzana Wroblowská, Ph.D. The work was aimed at a human factor which intensifies or reduces the effectiveness of product oriented marketing, which is designated as product management. The purpose was to verify functionality and validity of the organizational frame of marketing, to analyze product management state in present entrepreneurial routine in the Czech Republic and to identify role profile of product and brand managers as well as support corporal routine with a type position standard. Findings: The

Relationship between remnant hippocampus and amygdala and memory outcomes after stereotactic surgery for mesial temporal lobe epilepsy

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Malikova H

2015-11-01

Full Text Available Hana Malikova,1,2,* Lenka Kramska,3,* Zdenek Vojtech,4,5 Jan Sroubek,6 Jiri Lukavsky,7 Roman Liscak8 1Department of Radiology, Na Homolce Hospital, 2Institute of Anatomy, Second Medical Faculty, Charles University in Prague, 3Department of Clinical Psychology, Na Homolce Hospital, 4Department of Neurology, Na Homolce Hospital, 5Department of Neurology, 3rd Medical Faculty, Charles University in Prague, 6Department of Neurosurgery, Na Homolce Hospital, 7Institute of Psychology, Academy of Sciences of the Czech Republic, 8Department of Radiation and Stereotactic Neurosurgery, Na Homolce Hospital, Prague, Czech Republic *These authors contributed equally to this work Background and purpose: Mesial temporal structures play an important role in human memory. In mesial temporal lobe epilepsy (MTLE, seizure activity is generated from the same structures. Surgery is the definitive treatment for medically intractable MTLE. In addition to standard temporal lobe microsurgical resection, stereotactic radiofrequency amygdalohippocampectomy (SAHE is used as an alternative MTLE treatment. While memory impairments after standard epilepsy surgery are well known, it has been shown that memory decline is not a feature of SAHE. The aim of the present study was to correlate the volume of the remnant hippocampus and amygdala in patients treated by SAHE with changes in memory parameters.Materials and methods: Thirty-seven MTLE patients treated by SAHE (ten right, 27 left were included. Patients underwent magnetic resonance imaging examinations including hippocampal and amygdalar volumetry and neuropsychological evaluation preoperatively and 1 year after surgery.Results: Using Spearman correlation analyses, larger left-sided hippocampal reductions were associated with lower verbal memory performance (ρ=-0.46; P=0.02. On the contrary, improvement of global memory quotient (MQ was positively correlated with larger right-sided hippocampal reduction (ρ=0.66; P=0

Coordination of International Risk-Reduction Investigations by the Multilateral Human Research Panel for Exploration

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Charles, John B.; Bogomolov, Valery V.

2015-01-01

Effective use of the unique capabilities of the International Space Station (ISS) for risk reduction on future deep space missions involves preliminary work in analog environments to identify and evaluate the most promising techniques, interventions and treatments. This entails a consolidated multinational approach to biomedical research both on ISS and in ground analogs. The Multilateral Human Research Panel for Exploration (MHRPE) was chartered by the five ISS partners to recommend the best combination of partner investigations on ISS for risk reduction in the relatively short time available for ISS utilization. MHRPE will also make recommendations to funding agencies for appropriate preparatory analog work. In 2011, NASA's Human Research Program (HRP) and the Institute of Biomedical Problems (IBMP) of the Russian Academy of Science, acting for MHRPE, developed a joint US-Russian biomedical program for the 2015 one-year ISS mission (1YM) of American and Russian crewmembers. This was to evaluate the possibilities for multilateral research on ISS. An overlapping list of 16 HRP, 9 IBMP, 3 Japanese, 3 European and 1 Canadian investigations were selected to address risk-reduction goals in 7 categories: Functional Performance, Behavioral Health, Visual Impairment, Metabolism, Physical Capacity, Microbial and Human Factors. MHRPE intends to build on this bilateral foundation to recommend more fully-integrated multilateral investigations on future ISS missions commencing after the 1YM. MHRPE has also endorsed an on-going program of coordinated research on 6-month, one-year and 6-week missions ISS expeditions that is now under consideration by ISS managers. Preparatory work for these missions will require coordinated and collaborative campaigns especially in the psychological and psychosocial areas using analog isolation facilities in Houston, Köln and Moscow, and possibly elsewhere. The multilateral Human Analogs research working group (HANA) is the focal point of those

Time- and Space-Domain Measurements of the Thermal Conductivity in Diamond Anvil Cells

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Goncharov, A. F.

2011-12-01

that different techniques can be successfully used to determine the thermal conductivity of materials loaded in the DAC. The choice of the technique depends on material properties, sample preparation method, and P-T range needed. I thank D. Allen Dalton, David Cahill, Viktor Struzhkin, Wen-Pin Hsieh, Zuzana Konopkova, Peter Lazor, Javier A. Montoya for critically contributing to this work. I acknowledge support from NSF EAR 0711358 and EAR-1015239, Carnegie Institution of Washington, DOE/ NNSA (CDAC), and EFree, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Award No. DESC0001057. 1. P. Beck, A. F. Goncharov, V. V. Struzhkin, B. Militzer, H. K. Mao, R. J. Hemley (2007). Measurement of thermal diffusivity at high pressure using a transient heating technique, Appl Phys. Lett. 91, 181914. 2. K. V. Tretiakov and S. Scandolo (2004). Thermal conductivity of solid argon at high pressure and high temperature: A molecular dynamics study. Journal of Chemical Physics 121, 11177-11182. 3. Z. Konopkova, P. Lazor, A. F. Goncharov, V. V. Struzhkin (2011). Thermal conductivity of hcp iron at high pressure and temperature, High Pressure Research, 31, 228-236.

FY 1999 report on the results of R and D projects by local consortiums for immediate effects. R and D on advanced utilization of chondroitin sulfate derived from salmon nasal cartilage; 1999 nendo sake hana nankotsu yurai kondoroichin ryusan no kodo riyoka kenkyu seika hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

The R and D project has been conducted for production techniques and commercialization of salmon chondroitin sulfate (SCS) present in the salmon nasal cartilage. For the structural analysis of SCS, it is confirmed that sulfate group is distributed in SCS derived from the nasal cartilage by the analysis of unsaturated disaccharides. For the extraction and purification techniques, the SCS extraction process is optimized, to reduce extraction time to one-fourth, and thereby to reduce production cost. For application of SCS to cosmetics, the deodorization techniques using, e.g., ion-exchanged resin, are almost established, although some problems to be solved are left. For estimation of novel function of SCS, it is confirmed to possess some novel functions, e.g., inhibition of adhesion of E. coli O-157 to the intestinal tract and promotion of Ca absorption by the intestinal tract. For the powder drying techniques, the spray drier is improved by adopting tall-form type nozzles and a drying chamber to finely crushing SCS, and introducing a secondary drier, in order to reduce cost. For production of SCS films, it is found that the SCS film is high both in softness and tensile strength, and that it can easily form the blend film with sodium alginate. (NEDO)

Continuing to Confront COPD International Physician Survey: physician knowledge and application of COPD management guidelines in 12 countries

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Davis KJ

2014-12-01

Full Text Available Kourtney J Davis,1 Sarah H Landis,2 Yeon-Mok Oh,3 David M Mannino,4 MeiLan K Han,5 Thys van der Molen,6 Zaurbek Aisanov,7 Ana M Menezes,8 Masakazu Ichinose,9 Hana Muellerova11Worldwide Epidemiology, GlaxoSmithKline, Wavre, Belgium; 2Worldwide Epidemiology, GlaxoSmithKline, Uxbridge, UK; 3University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea; 4University of Kentucky College of Public Health, Lexington, KY, USA; 5Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, USA; 6University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; 7Pulmonology Research Institute, Moscow, Russia; 8Federal University of Pelotas, Pelotas, Brazil; 9Tohoku University Graduate School of Medicine, Sendai, JapanAim: Utilizing data from the Continuing to Confront COPD (chronic obstructive pulmonary disease International Physician Survey, this study aimed to describe physicians’ knowledge and application of the GOLD (Global initiative for chronic Obstructive Lung Disease Global Strategy for the Diagnosis, Management and Prevention of COPD diagnosis and treatment recommendations and compare performance between primary care physicians (PCPs and respiratory specialists.Materials and methods: Physicians from 12 countries were sampled from in-country professional databases; 1,307 physicians (PCP to respiratory specialist ratio three to one who regularly consult with COPD, emphysema, or chronic bronchitis patients were interviewed online, by telephone or face to face. Physicians were questioned about COPD risk factors, prognosis, diagnosis, and treatment, including knowledge and application of the GOLD global strategy using patient scenarios.Results: Physicians reported using spirometry routinely (PCPs 82%, respiratory specialists 100%; P<0.001 to diagnose COPD and frequently included validated patient-reported outcome measures (PCPs 67%, respiratory specialists 81%; P<0.001. Respiratory

Continuing to Confront COPD International Patient Survey: methods, COPD prevalence, and disease burden in 2012–2013

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Landis SH

2014-06-01

Full Text Available Sarah H Landis,1 Hana Muellerova,1 David M Mannino,2 Ana M Menezes,3 MeiLan K Han,4 Thys van der Molen,5 Masakazu Ichinose,6 Zaurbek Aisanov,7 Yeon-Mok Oh,8 Kourtney J Davis,9 1Worldwide Epidemiology, GlaxoSmithKline, Uxbridge, UK; 2University of Kentucky College of Public Health, Lexington, KY, USA; 3Federal University of Pelotas, Pelotas, Brazil; 4Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, USA; 5University Medical Center Groningen, Groningen, Netherlands; 6Tohoku University Graduate School of Medicine, Sendai, Japan; 7Pulmonology Research Institute, Moscow, Russia; 8University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea; 9Worldwide Epidemiology, GlaxoSmithKline, Wavre, Belgium Purpose: The Continuing to Confront COPD International Patient Survey aimed to estimate the prevalence and burden of COPD globally and to update findings from the Confronting COPD International Survey conducted in 1999–2000. Materials and methods: Chronic obstructive pulmonary disease (COPD patients in 12 countries worldwide were identified through systematic screening of population samples. Telephone and face-to-face interviews were conducted between November 2012 and May 2013 using a structured survey that incorporated validated patient-reported outcome instruments. Eligible patients were adults aged 40 years and older who were taking regular respiratory medications or suffered with chronic respiratory symptoms and reported either 1 a physician diagnosis of COPD/emphysema, 2 a physician diagnosis of chronic bronchitis, or 3 a symptom-based definition of chronic bronchitis. The burden of COPD was measured with the COPD Assessment Test (CAT and the modified Medical Research Council (mMRC Dyspnea Scale. Results: Of 106,876 households with at least one person aged ≥40 years, 4,343 respondents fulfilled the case definition of COPD and completed the full survey. COPD prevalence ranged from 7% to 12%, with

Continuing to Confront COPD International Surveys: comparison of patient and physician perceptions about COPD risk and management

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Menezes AM

2015-01-01

Full Text Available Ana M Menezes,1 Sarah H Landis,2 MeiLan K Han,3 Hana Muellerova,2 Zaurbek Aisanov,4 Thys van der Molen,5 Yeon-Mok Oh,6 Masakazu Ichinose,7 David M Mannino,8 Kourtney J Davis9 1Federal University of Pelotas, Pelotas, Brazil; 2Worldwide Epidemiology, GlaxoSmithKline, Uxbridge, UK; 3Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, USA; 4Pulmonology Research Institute, Moscow, Russia; 5University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; 6University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea; 7Tohoku University Graduate School of Medicine, Sendai, Japan; 8University of Kentucky College of Public Health, Lexington, KY, USA; 9Worldwide Epidemiology, GlaxoSmithKline, Wavre, Belgium Purpose: Using data from the Continuing to Confront COPD International Physician and Patient Surveys, this paper describes physicians’ attitudes and beliefs regarding chronic obstructive pulmonary disease (COPD prognosis, and compares physician and patient perceptions with respect to COPD. Methods: In 12 countries worldwide, 4,343 patients with COPD were identified through systematic screening of population samples, and 1,307 physicians who regularly saw patients with COPD were sampled from in-country professional databases. Both patients and physicians completed surveys about their COPD knowledge, beliefs, and perceptions; physicians answered further questions about diagnostic methods and treatment choices for COPD. Results: Most physicians (79% responded that the long-term health outlook for patients with COPD has improved over the past decade, largely attributed to the introduction of better medications. However, patient access to medication remains an issue in many countries, and some physicians (39% and patients (46% agreed/strongly agreed with the statement “there are no truly effective treatments for COPD”. There was strong concordance between physicians and patients

Recording of hospitalizations for acute exacerbations of COPD in UK electronic health care records

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Rothnie KJ

2016-11-01

Full Text Available Kieran J Rothnie,1,2 Hana Müllerová,3 Sara L Thomas,2 Joht S Chandan,4 Liam Smeeth,2 John R Hurst,5 Kourtney Davis,3 Jennifer K Quint1,2 1Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, UK; 2Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK; 3Respiratory Epidemiology, GlaxoSmithKline R&D, Uxbridge, London; 4Medical School, 5UCL Respiratory, University College London, London, UK Background: Accurate identification of hospitalizations for acute exacerbations of chronic obstructive pulmonary disease (AECOPD within electronic health care records is important for research, public health, and to inform health care utilization and service provision. We aimed to develop a strategy to identify hospitalizations for AECOPD in secondary care data and to investigate the validity of strategies to identify hospitalizations for AECOPD in primary care data. Methods: We identified patients with chronic obstructive pulmonary disease (COPD in the Clinical Practice Research Datalink (CPRD with linked Hospital Episodes Statistics (HES data. We used discharge summaries for recent hospitalizations for AECOPD to develop a strategy to identify the recording of hospitalizations for AECOPD in HES. We then used the HES strategy as a reference standard to investigate the positive predictive value (PPV and sensitivity of strategies for identifying AECOPD using general practice CPRD data. We tested two strategies: 1 codes for hospitalization for AECOPD and 2 a code for AECOPD other than hospitalization on the same day as a code for hospitalization due to unspecified reason. Results: In total, 27,182 patients with COPD were included. Our strategy to identify hospitalizations for AECOPD in HES had a sensitivity of 87.5%. When compared with HES, using a code suggesting hospitalization for AECOPD in CPRD resulted in a PPV of 50.2% (95

Statutes of Limitation for Sexual Offenses Against Children Fyrning kynferðisbrota gegn börnum

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Svala Ísfeld Ólafsdóttir

2007-12-01

Full Text Available Abstract in English is unavailable.Hér á eftir er rakinn aðdragandi þeirra breytinga sem gerðar voru á fyrningarreglum almennra hegningarlaga vegna kynferðisbrota gegn börnum síðasta vor með lögum nr. 61/2007. Ein þeirra fól í sér að alvarleg kynferðisbrot gegn börnum fyrnast nú ekki. Frá refsipólitísku og afbrotafræðilegu sjónarmiði er þessi breyting athyglisverð. Í henni felst frávik frá þeirri stefnumörkun löggjafans til langs tíma að fækka ófyrnanlegum brotum og að eingöngu þau brot sem geta varðað ævilöngu fangelsi skuli vera ófyrnanleg. Ekkert þeirra kynferðisbrota sem breytingin tekur til getur varðað svo þungri refsingu. Breytingin átti sér langan aðdraganda, þótt svo mætti virðast af ferli málsins á Alþingi vorið 2007 að hana hafi borið brátt að. Fjöldi frumvarpa sem að þessu snúa hefur verið lagður fram á Alþingi síðari ár og umræður á þeim vettvangi um eðli kynferðisbrota gegn börnum, rannsóknir fagfólks og reynslusögur fórnarlamba kynferðisbrota og lýsingar þeirra á afleiðingum brotanna á lífshlaup sitt, skýra þetta frávik frá meginstefnu löggjafans að verulegu leyti. Ákvörðunin var tekin eftir mikil skoðanaskipti og umræður. Aðdragandinn sýnir að breytingin byggist á sérstöku eðli þessara brota og felur í sér áherslu á alvarlegar og langvarandi afleiðingar þeirra fyrir fórnarlömbin, sem taldar eru vega þyngra en almenn rök að baki fyrningarreglum um réttarstöðu brotamanns, erfiðleika við rannsókn brotanna og sönnun. Á hinn bóginn má vera að vegna þessara vandkvæða feli breytingin fyrst og fremst í sér táknræna viðurkenningu löggjafans á alvarleika brotanna, fremur en að hún eigi eftir að hafa mikla raunhæfa þýðingu.

The position of the political parties before the general election in 2007 from a marketing perspective Markaðsfræðilegt sjónarhorn á stöðu stjórnmálaflokka fyrir alþingiskosningarnar 2007

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Þórhallur Guðlaugsson

2008-06-01

Full Text Available Abstract in English is unavailable.Viðfangsefni greinarinnar er mat á staðfærslu stjórnmálaflokka og hvernig ímynd og staðfærsla tengjast faglegu markaðsstarfi, samkeppnishæfni og árangri. Fjallað er um niðurstöður rannsóknar þar sem lagt er mat á staðfærslu stjórnmálaflokka hjá ungu fólki og skoðað með hvaða hætti hún endurspeglar árangur í kosningum. Í þessu sambandi eiga stjórnmálaflokkar í nokkrum vanda. Stjórnmálaflokkar eru ekki fyrirtæki þar sem hægt er að gefa út tiltekna línu hvað samskipti og skilaboð varðar. Vissulega reyna menn þó að stilla saman strengi sína, sérstaklega í kosningabaráttunni. Þar virðast flestir flokkar leggja áherslu á loforð, þ.e. kjósi menn flokkinn þá muni þetta eða hitt gerast eða breytast eftir kosningar. Fólk virðist þó ekki gera ráð fyrir því að stjórnmálamenn standi við gefin loforð og virðast margir bera meira traust til einstaklinga almennt en stjórnmálamanna. Kjósendur hafa iðulega óljósa mynd af því fyrir hvað tiltekinn stjórnmálaflokkur stendur en ýmislegt bendir til þess að tengsl séu á milli staðfærslu og árangurs í kosningum. Þrír stjórnmálaflokkar virðast hafa skýra og afgerandi stöðu hjá ungu fólki, Sjálfstæðisflokkurinn, Vinstrihreyfingin grænt framboð og Framsóknarflokkurinn. Tveir þeirra tengjast jákvæðum eiginleikum en einn neikvæðum gildum. Tveir stjórnmálaflokkar virðast hafa óljósa stöðu í huga ungra kjósenda, Samfylkingin og Frjálslyndi flokkurinn. Hafa þarf í huga að staðfærsla verður ekki mæld í eitt skipti fyrir öll og mikilvægt að mæla hana reglulega ef niðurstöðurnar eiga að nýtast í faglegu markaðsstarfi flokkanna.

Human Clade 2.3.4.4 A/H5N6 Influenza Virus Lacks Mammalian Adaptation Markers and Does Not Transmit via the Airborne Route between Ferrets.

Science.gov (United States)

Herfst, Sander; Mok, Chris K P; van den Brand, Judith M A; van der Vliet, Stefan; Rosu, Miruna E; Spronken, Monique I; Yang, Zifeng; de Meulder, Dennis; Lexmond, Pascal; Bestebroer, Theo M; Peiris, J S Malik; Fouchier, Ron A M; Richard, Mathilde

2018-01-01

Since their emergence in 1997, A/H5N1 influenza viruses of the A/goose/Guangdong/1/96 lineage have diversified in multiple genetic and antigenic clades upon continued circulation in poultry in several countries in Eurasia and Africa. Since 2009, reassortant viruses carrying clade 2.3.4.4 hemagglutinin (HA) and internal and neuraminidase (NA) genes of influenza A viruses of different avian origin have been detected, yielding various HA-NA combinations, such as A/H5N1, A/H5N2, A/H5N3, A/H5N5, A/H5N6, and A/H5N8. Previous studies reported on the low pathogenicity and lack of airborne transmission of A/H5N2 and A/H5N8 viruses in the ferret model. However, although A/H5N6 viruses are the only clade 2.3.4.4 viruses that crossed the species barrier and infected humans, the risk they pose for human health remains poorly characterized. Here, the characterization of A/H5N6 A/Guangzhou/39715/2014 virus in vitro and in ferrets is described. This A/H5N6 virus possessed high polymerase activity, mediated by the E627K substitution in the PB2 protein, which corresponds to only one biological trait out of the three that were previously shown to confer airborne transmissibility to A/H5N1 viruses between ferrets. This might explain its lack of airborne transmission between ferrets. After intranasal inoculation, A/H5N6 virus replicated to high titers in the respiratory tracts of ferrets and was excreted for at least 6 days. Moreover, A/H5N6 virus caused severe pneumonia in ferrets upon intratracheal inoculation. Thus, A/H5N6 virus causes a more severe disease in ferrets than previously investigated clade 2.3.4.4 viruses, but our results demonstrate that the risk from airborne spread is currently low. IMPORTANCE Avian influenza A viruses are a threat to human health, as they cross the species barrier and infect humans occasionally, often with severe outcome. The antigenic and genetic diversity of A/H5 viruses from the A/goose/Guangdong/1/96 lineage is increasing, due to continued

Concentrations of selected heavy metals in bryophyte tissues at Cu-mine heap Podlipa in Ľubietová (Central Slovakia)

Science.gov (United States)

Širka, Pavel; Midula, Pavol

2017-04-01

absorption spectrometry with flame atomization (AVANTA Σ, GBC) was used. Concentrations of Fe in bryophyte samples were significantly higher compared to those in the soil and on average quite similar to those in vascular plants. Differences in contents of Cu were the most significant from all analyzed chemical elements. The highest concentrations of Cu in bryophyte samples were observed in both samples (9 and 10) of Pohlia drummondii (4010.3 mg.kg-1 and 1900.8 mg.kg-1 respectivelly), which in sample 9 was 18 to 470 times higher than in other bryophyte samples, slightly higher than the average value in the soil (3253 mg.kg-1) and considerably higher than in the leaves of Mentha longifolia (173.3 mg.kg-1), which had the highest concentration of Cu among vascular plants. Concentrations of Zn and Cd in bryophyte samples were on average slightly higher than in soil and vascular plant samples. On average, concentrations of Pb were considerably lower in bryophyte samples than in soil and vascular plant species. No significant differences were observed in Mn. Given their specific anatomy and morphology, there is a dispute in various studies as to whether a certain heavy metal is indeed the controlling factor for the distribution of bryophytes on metal-contaminated sites. Perhaps the tendency of these mosses to grow on mineralized substrates is a species characteristic, not a mutual one. Detailed study of bryophytes in relation to phytoextraction or phytostabilization of heavy metals may be used in succession management process aimed at restoring the environment, particularly the soil and air. Aknowledgement: This work was realised with the help of doc. RNDr. Zuzana Melichová, PhD. and Peter Harčár from the Department of Chemistry, Faculty of Natural Sciences, Matej Bel University in Banská Bystrica and financially supported by grant scheme VEGA 1/0538/15.

Editorial

Directory of Open Access Journals (Sweden)

Dana Kapitulčinová

2013-12-01

Sciences, Philosophy, and Theology (Reviewed Paper by Zuzana Svobodová. This philosophical text analyses the work of Josef Petr Ondok – Czech theologian, philosopher and biologist – from the perspective of ethics and ecoethics. 4 The Purpose of Education: Australian and Slovenian perspectives in Education for Sustainability (Inspiration by Phil Smith and Majda Naji. The authors present their view on the purpose of education in the context of sustainable development and include examples of education for sustainable development from their countries – Slovenia and Australia. 5 Environmental mining limits in the North Bohemian Lignite Region. Book review: Říha, M., Stoklasa, J., Lafarová, M., Dejmal, I., Marek, J., Pakosta, P., Beránek, K. Environmental mining limits in the North Bohemian Lignite Region. Společnost pro krajinu, Praha 2005. Translation: Petr Kurfürst. This book review written by Andrew Barton looks at the issue of mining limits in the region of North-West Bohemia in the Czech Republic and briefly summarises from the content of the book originally published in 2005 (in Czech, but later translated into English supplemented with the most up-to-date information on the current situation. 6 Informational texts: A very interesting article on environmental literacy by Petr Daniš, originally published as a reviewed article in Czech (Envigogika 3/2013, has been translated into English and is now available to our readers. School teachers might be interested in the announcement of a school essay competition run by The Living Rainforest, a UK-based charity. 7 Related announcements: As we feel that dialogue on environmental education and ESD related issues in CZ should be promoted nationally and internationally, this time we are publishing two issues simultaneously (for the content of the Czech issue of Envigogika, see here. We wish you inspirational reading and a peaceful Christmas holiday, as well as a successful New Year. The Envigogika editorial team In

Ground-Water Occurrence and Contribution to Streamflow, Northeast Maui, Hawaii

Science.gov (United States)

Gingerich, Stephen B.

1999-01-01

-elevation saturated zone. Total average daily ground-water discharge from the high-elevation saturated zone upstream of 1,200 feet altitude is greater than 38 million gallons per day, all of which is eventually removed from the streams by surface-water diversion systems. Perennial streamflow has been measured at altitudes greater than 3,000 feet in several of the streams. Discharge from the high-elevation saturated zone is persistent even during periods of little rainfall. The total average annual streamflow of the gaged streams east of Keanae Valley is about 109 million gallons per day at about 1,300 feet altitude. It is not possible to estimate the total average annual streamflow at the coast nor at higher altitudes. All of the base flow measured east of Keanae Valley represents ground-water discharge from the vertically extensive freshwater-lens system. Total average daily ground-water discharge to gaged streams upstream of 1,200 feet altitude is about 27 million gallons per day. About 19 million gallons per day of ground water discharges through the Kula and Hana Volcanics between about 500 feet and 1,300 feet altitude in the gaged stream sub-basins. About 13 million gallons per day of this discharge is in Hanawi Stream. The total ground-water discharge above 500 feet altitude in this part of the study area is greater than 56 million gallons per day.

Emissions from animal husbandry. Greenhouse gases, environmental assessment, state of the art; Emissionen der Tierhaltung. Treibhausgase, Umweltbewertung, Stand der Technik

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

: Nitrogen and phosphorus flows in pig production (Dennis Otten); (36) Seasonal effect on emissions of ammonia and greenhouse gases in fattening pigs (Zuzana Palkovicova); (37) Greenhouse gas emissions and evaluation of sustainability aspects in dairy farming - data collection on farms, modelling, life cycle assessment (Hans Marten Paulsen); (38) Methodology of a systematic cost-benefit analysis of mitigation strategies for emissions from livestock farming (Regina Roessler); (39) Measuring concept for the quantification of emissions from naturally ventilated housings for dairy cattle (Sabine Schrade); (40) Reduction of ammonia concentration in growing-finishing pigs with FRESTA {sup registered} F Plus (Martin Veit); (41) Measurements in and around intensive livestock farms: Dust, ammonia, greenhouse gases and bioaerosols (Heinz Riedel).

Epidemiological survey of low pathogenic avian influenza viruses in poultry in Eastern China%2009—2010年华东地区家禽低致病性禽流感病毒的流行病学调查与分析

Institute of Scientific and Technical Information of China (English)

赵坤坤; 仲书官; 赵国; 阮丽莎; 朱艳梅; 张妍; 段志强; 刘晓文; 刘文博; 彭大新; 刘秀梵

2012-01-01

为了解华东地区家禽中低致病性禽流感病毒（low pathogenic avian influenza viruses,LPAIVs）的分布规律,从2009年10月到2010年9月在华东地区某活禽市场采集鸡、鸭、鹅等家禽的泄殖腔拭子共1 650份,经鸡胚接种和HA、HI试验鉴定,结果从58份样品中分离到了LPAIVs,总分离率为3.51%。所分离到的6种HA亚型及各HA亚型分离率从高到底依次为：H6、H3、H1、H4、H9、H11。从这些样品中鉴定出7种NA亚型,包括N1、N2、N3、N4、N5、N6、N8,二者之间有11种组合。家鸭样品中LPAIVs的分离率为7.28%,显著高于鸡源样品的分离率1.00%和鹅源样品的分离率1.02%。LPAIVs的季节性分布较为明显,3～6月份和10～12月份的分离率较高,而冬季最冷的1月份和夏季最热的7月份则没有分离到。2种或2种以上不同HA亚型混合感染的样品有6份,全部为水禽源样品,占总阳性样品数的10.34%。这些数据表明活禽市场可以作为AIV的一个重要储存库,而家养水禽可作为AIV的一个重要储存宿主,应该继续加强对活禽市场,尤其是家养水禽中AIV的监测。%To investigate the epidemiology of low pathogenic avian influenza viruses（LPAIVs） in Eastern China,we surveyed LPAIVs in a live-poultry market（LPM） in Eastern China from October 2009 to September 2010,and 58 from 1 650 cloaca swab samples were positive for LPAIVs in isolation when characterized by hemagglutination（HA） and hemagglutination inhibition（HI） tests.These LPAIVs belonged to six HA subtypes,that is H6,H3,H1,H4,H9 and H11,in the order of isolation rate.In addition,seven NA subtypes including N1,N2,N3,N4,N5,N6 and N8 were identified in these LPAIVs.Altogether 11 HA-NA subtype combinations were identified in our study.The isolation rate from domestic ducks was 7.28%,which was much higher than that from chickens（1.00%） and domestic geese（1.02%）.The isolation rate of LPAIVs was distributed with significant

Ambitious Icelanders: The Background and Beginning of Icelandic International Development Stórhuga Íslendingar: Forsaga og upphaf íslenskrar þróunarsamvinnu

Directory of Open Access Journals (Sweden)

Kristín Loftsdóttir

2011-12-01

æri sem hefðu yfir að ráða tæknilegri sérfræðiþekkingu sem færa myndi samfélög frá einu stigi þróunar yfir á annað. Söfnun upplýsinga til að staðsetja samfélög á þróunarskala náði til smæstu þátta mannlegs samfélags og gaf hugmyndinni um þróunarlönd áþreifanlegt inntak. Í greinin er upphaf íslenskrar þróunarsamvinnu skoðað og leitast við að setja hana í samhengi við alþjóðlegar hugmyndir um þróunarsamvinnu. Umfjöllunin hefst á umræðu um mótun alþjóðlegrar þróunarsamvinnu út í hinum stóra heimi og hugmyndafræðilegt forræði hennar. Síðan er gerð grein fyrir því hvernig viðfangsefnið "þróunarlönd" birtist í íslensku samhengi á ákveðnu tímabili og hvernig má sjá áhrif frá alþjóðlegum straumum, sem endurspeglast meðal annars í auknum þrýstingi á stjórnvöld að hefja þróunarsamvinnu. Fyrstu skref stofnunarinnar Aðstoð Íslands við þróunarlöndin sem sett var á fót 1971 endurspegla þó lítinn áhuga stjórnvalda á þróunarsamvinnu. Greinin varpar einnig ljósi á áhrif þessa alþjóðlegu straumar á Íslandi og hvernig þeir virkjuðu hluta þjóðarinnar í ákalli um mikilvægi þess að íslenska þjóðin sinnti þróunarsamvinnu.

The competitiveness of the Icelandic film industry Samkeppnishæfni íslenska kvikmyndaiðnaðarins

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Konráð Pálmason

2011-06-01

kvikmyndasjóða mun leiða til þess að færri kvikmyndaverk (t.d. kvikmyndir og sjónvarpsþættir verði framleidd og starfsfólki fækki í greininni. Þetta mun draga umtalsvert úr vexti og hamla framþróun atvinnugreinarinnar. Heildartekjur kvikmyndaiðnaðarins af innlendum og erlendum kvikmyndaverkefnum sl. áratug eru áætlaðar um 9 milljarðar króna. Tilgangur rannsóknar höfunda er að greina samkeppnishæfni kvikmyndaiðnaðarins á Íslandi og að hve miklu leyti hún er byggð á klasasamstarfi. Aðferðafræði rannsóknarinnar fólst í eigindlegum opnum viðtölum við lykilstjórnendur í atvinnugreininni. Kvikmyndaiðnaðurinn er að hluta til samkeppnishæfur. Styrkleiki hans er m.a. hversu einfalt og skilvirkt endurgreiðslukerfi ríkisins til kvikmyndaverkefna er í framkvæmd. Aðrir styrkleikar eru stórbrotin náttúra og auðvelt aðgengi að ólíkum tökustöðum. Góðir innviðir, lítið skrifræði og vinnusamt og hæft vinnuafl hafa jákvæð áhrif á samkeppnishæfni atvinnugreinarinnar. Veikleikarnir eru hins vegar að lítil klasamyndun hefur átt sér stað innan greinarinnar, ásamt því að lítil vitund er um samlegðaráhrif sem geta eflt greinina. Heimamarkaðurinn er of lítill og miklar sveiflur í eftirspurn hafa torveldað vöxt greinarinnar. Endurgreiðsluhlutfall ríkisins þarf að hækka úr 20% í 25-30% til að atvinnugreinin geti talist fyllilega samkeppnishæf alþjóðlega. Almenn efnahagsskilyrði hafa dregið úr samkeppnishæfni atvinnugreinarinnar, s.s. óstöðugur gjaldmiðill og gjaldeyrishöft þó lægra gengi hafi styrkt hana. Niðurstöður rannsóknarinnar hafa hagnýtt gildi bæði fyrir atvinnugreinina og stjórnvöld.

Production of Short-Lived Radionuclides at the Hahn-Meitner Institute in West Berlin; Production de Radionuclides a Courte Periode a l'Institut Hahn-Meitner de Berlin-Ouest; ПРОИЗВОДСТВО КОРОТКОЖИВУЩИХ РАДИОИЗОТОПОВ В ИНСТИТУТЕ ХАНА-МАЙТНЕРА В ЗАПАДНОМ БЕРЛИНЕ; Produccion de Radionuclidos de Periodo Corto en el Instituto Hahn-Meitner de Berlin Occidental

Energy Technology Data Exchange (ETDEWEB)

Felix, F. W.; Pirrwitz, D.; Szabo de Bucs, E. [Hahn - Meitner-Institut fuer Kern Forschung, Berlin, Federal Republic of Germany (Germany)

1963-03-15

la capadidad de produccion del citado Instituto. (author) [Russian] Nachinaja s I960 goda Institut po jdernym issledovanijam Hana-Majtnera proizvodit korotkozhivushhie radioizotopy dlja medicinskih i nauchnyh celej dlja rajona Zapadnogo Berlina. V nastojashhee vremja proizvodjatsja izotopy, primenjaemye obychno v medicine, takie, kak Na{sup 25}, K{sup 42}, Au{sup 198}, a takzhe nekotorye menee rasprostranennye, kak Cu{sup 64}, Zn{sup 69m} i F{sup 18}. Na{sup 24} i K{sup 42} byli polucheny v rezul'tate nejtronnogo obluchenija hloridov i razoslany posle kalibrovki v vide tverdyh veshhestv. Au1 Registered-Sign 8, obluchennyj v forme metalla, upotrebljaetsja dlja implantacii pri lechenii raka. F{sup 19} poluchaetsja v rezul'tate reakcii O{sup 16} (t, n) i obluchenija LiNO{sub 3} Otdelenie F{sup 16} pri pomoshhi ionnogo obmena dalo luchshie rezul'taty, chem opisyvaemye obychno v literature metody. Dlja proizvodstva Cu{sup 64} i Zn{sup 89m} byl razrabotan special'nyj metod jelektroliza dlja jekstragirovanija izotopov, poluchennyh pri pomoshhi reakcii Scilard-Hal'mersa s ftalocianinami. Oba jeti izotopa nahodjat primenenie v medicinskoj diagnostike. Privodjatsja podrobnye dannye otnositel'no oborudovanija i tehniki obluchenija, sposobov proizvodstva i apparatury, kalibrovki poluchennyh izotopov i proizvoditel'noj sposobnosti. (author)

Úvodník

Directory of Open Access Journals (Sweden)

Jana Dlouhá

2013-10-01

předminulého čísla Envigogiky pouští také Peter Sabo a Ľudmila Sabová – vymezují se vůči zatvrzelému „popírači kultury“ profesoru Šmajsovi, a stejně jako Jiří Nečas vidí cestu v navázání na její nejlepší tradice. Text publikujeme včetně recenzí, které přinášejí nové pohledy na tento problém a odkazy do literatury. Lehce se dotkneme i uměleckého uchopení přírody: jak funguje „umění v krajině“ popisuje v recenzi nově vydané knížky o land artu Hana Kolářová. A Jiří Olšovský se pokouší sdělit, jak lze do vztahu k přírodě vstoupit i dnes, ve věku ovládaném technikou. Do jiného soudku patří texty, které se zabývají rolí vědy a politiky při zařizování kvalitního, dlouhodobě udržitelného života. Vtipně a přitom s erudicí psaný text Františka Kožíška a Petra Pumanna se věnuje úskalím, která může potkat vědec, pokud chce svědomitě sdělit své výsledky veřejnosti. Autoři popisují, jak se postupně podstata jejich sdělení „ztratila v překladu“ do stručných mediálních zpráv a především jejich titulků – uvažují, jak by se dalo zkreslením tohoto druhu vyhnout, aniž by se věda uzavřela sama do sebe. I v tomto čísle se věnujeme možnostem hodnocení EV, tentokrát ve velmi komplexním a zasvěceném pohledu na environmentální gramotnost z dílny Petra Daniše, který nám podal zprávu (nejen o připravovaném výzkumu PISA v roce 2015. Osvětu veřejnosti v ochraně přírody a význam zapojení různých společenských skupin mají na mysli Peter Repka a Milada Švecová, když představují způsob, jak efektivně analyzovat management chráněných území. Jana Laciná a Vlastimil Kostkan se pokoušejí zprostředkovat široké veřejnosti nejnovější poznatky z přírodovědných i společensko-vědních oborů souvisejících se životním prostředím, a podávají nám o tom zprávu. Mozaiku doplňuje pohled do blízké minulosti