WorldWideScience

Sample records for hana lotakova zuzana

  1. Software development on the SAP HANA platform

    CERN Document Server

    Walker, Mark

    2013-01-01

    Software Development on the SAP HANA Platform is a general tutorial guide to SAP HANA.This book is written for beginners to the SAP HANA platform. No knowledge of SAP HANA is necessary to start using this book.

  2. Aplikace SAP HANA

    OpenAIRE

    2014-01-01

    The work is dedicated to analysis of data using ICT. It is clear that the classical way of dealing with the data is not satisfactory. Therefore, the new number of tools that changing the view of working with data has occured. An example is the SAP system HANA. The main aim of this thesis is to introduce SAP HANA platform as a tool for analytical processing of large amounts of data (especially in wide area-based marketing and customer relationship management) on the example SAP Customer Engage...

  3. SAP HANA cookbook

    CERN Document Server

    Chandrasekhar

    2013-01-01

    An easy-to-understand guide, covering topics using practical scenarios and live examples, and answering all possible questions.If you are a solution architect, developer, modeler, sales leader, business transformation managers, directors, COO, or CIO; this book is perfect for you.If you are interested in other technologies and want to jump-start into SAP, this book gives you the chance to learn SAP HANA. Basic knowledge of RDBMS concepts enough is to get you started.

  4. The regulation of HanA during heterocyst development in cyanobacterium Anabaena sp. PCC 7120.

    Science.gov (United States)

    Lu, Jing-Jing; Shi, Lei; Chen, Wen-Li; Wang, Li

    2014-10-01

    In response to deprivation of combined nitrogen, the filamentous cyanobacterium Anabaena sp. strain PCC 7120 develops heterocyst, which is specifically involved in the nitrogen fixation. In this study, we focused on the regulation of HanA, a histone-like protein, in heterocyst development. Electrophoretic mobility shift assay results showed that NtcA, a global nitrogen regulator necessary for heterocyst differentiation, could bind to two NtcA-binding motifs in the hanA promoter region. qPCR results also showed that NtcA may regulate the expression of hanA. By using the hanA promoter-controlled gfp as a reporter gene and performing western blot we found that the amount of HanA in mature heterocysts was decreased gradually.

  5. Characterization of Oxide Layer with Precipitates of HANA-6 Exposed in Simulated PWR Primary Water Environment

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Hun; Lim, Jea Young; Lee, Sung Yong; Kim, Yoon Ho; Mok, Yong Kyoon [KEPCO NF, Daejeon (Korea, Republic of)

    2016-10-15

    The delayed oxidation behaviors of β-Nb ppts and their amorphization behaviors in HANA-6 and other Zr-base alloys have been frequently reported. On the other hand, although Zr(Nb,Fe)2 ppts could be formed in the HANA-6 alloy due to Fe impurities contained in Zrsponge, the oxidation behavior of Zr(Nb,Fe)2 ppts contained in HANA-6 alloy has not been fully understood. In this study, oxide characteristics of HANA-6 corroded in simulated PWR environment for 165 and 315 days were investigated. And, oxidation behaviors of Zr(Nb,Fe)2 ppts contained in HANA-6 alloy were investigated by TEM with EDS techniques. The superior corrosion property of HANA-6 has been confirmed through corrosion test in simulated PWR water for 387 days. By using TEM/EDS technique, the oxide characteristics with presence of β- Nb (or β-enriched), and ZrNbFe (possibly Zr(Nb,Fe){sub 2}) ppts have been characterized as follows. 1. Delayed oxidation behaviors of β-Nb and Zr(Nb,Fe){sub 2} ppts and their amorphization due to oxidation were observed from TEM/EDS analyses. 2. The oxide layers having crystallite and partially amorphous ppts were slightly increased with increasing corrosion test time from 165 days to 315 days. 3. In outer oxide layer, Fe in Zr(Nb,Fe){sub 2} ppt was depleted and dissolved to outer layer of ppt and bulk oxide layer.

  6. Zavedení SAP HANA a SLT do firmy pro akceleraci analýzy ziskovosti

    OpenAIRE

    2015-01-01

    Podstatou této bakalářské práce je dokončení zadaného projektu zavedení SAP HANA technologie v roli akcelerátoru pro podnikový ERP systém, konkrétně pro modul CO-PA. Součástí je i základní teorie z oblasti databázových systémů a popis SAP HANA a SLT technologií. Díky nim by měla firma být schopná rychlé analýzy vlastních financí a na základě jejich výsledků pružně reagovat změnami firemní struktury nebo strategie. The main purpose of this bachelor's thesis is to complete the given project ...

  7. Hana Cervinkova, Playing Soldiers in Bohemia: An Ethnography of NATO Membership. Prague Studies in Sociocultural Anthropology 4, 2006, 161 pages.

    Directory of Open Access Journals (Sweden)

    Marybeth Peterson Ulrich

    2007-06-01

    Full Text Available Hana Cervinkova’s ethnographic portrait of the Czech military in its “post-socialist” moment is a fascinating contribution to the literature on post-communist transitions. Not merely concerned with the provision of several anthropological descriptions of disappearing cultures, such as the obsolescent enlisted ranks and Air Force technicians expert in the mechanics of moth-balled Soviet aircraft, Cervinkova is determined to link the military’s post-socialist story to the Czech state’s own fort...

  8. Seasonal dynamics of Proteocephalus sagittus in the stone loach Barbatula barbatula from the Hana River, Czech Republic.

    Science.gov (United States)

    Jarkovský, J; Koubková, B; Scholz, T; Prokes, M; Barus, V

    2004-09-01

    The seasonal cycle of the cestode Proteocephalus sagittus (Cestoda: Proteocephalidae) was studied for the first time in the stone loach Barbatula barbatula from the Hana River, Czech Republic. A total of 180 loaches were examined monthly from January to December 2001. The parasite occurred in loaches throughout the year but infection parameters differed significantly among seasons, with the highest values of prevalence and abundance from the late winter to the early summer. Parasite recruitment took place in the winter and early spring and the worms sexually matured in the late spring and early summer. In contrast to P. torulosus, the gravid worms of which laid eggs only at the end of the spring/beginning of the summer, gravid worms of P. sagittus were also found, although in low numbers, in the autumn and early winter. The rate of infection of loach with P. sagittus was neither dependent on the sex nor on the size of its fish host.

  9. Phase 1 archaeological investigation, cultural resources survey, Hawaii Geothermal Project, Makawao and Hana districts, south shore of Maui, Hawaii

    Energy Technology Data Exchange (ETDEWEB)

    Erkelens, C. [International Archaeological Research Inst., Inc., Honolulu, HI (United States)

    1995-04-01

    This report details the archaeological investigation of a 200 foot wide sample corridor extending approximately 9 miles along the southern portion of Maui within the present districts of Hana and Makawao. The survey team documented a total of 51 archaeological sites encompassing 233 surface features. Archaeological sites are abundant throughout the region and only become scarce where vegetation has been bulldozed for ranching activities. At the sea-land transition points for the underwater transmission cable, both Ahihi Bay and Huakini Bay are subjected to seasonal erosion and redeposition of their boulder shorelines. The corridor at the Ahihi Bay transition point runs through the Maonakala Village Complex which is an archaeological site on the State Register of Historic Places within a State Natural Area Reserve. Numerous other potentially significant archaeological sites lie within the project corridor. It is likely that rerouting of the corridor in an attempt to avoid known sites would result in other undocumented sites located outside the sample corridor being impacted. Given the distribution of archaeological sites, there is no alternative route that can be suggested that is likely to avoid encountering sites. Twelve charcoal samples were obtained for potential taxon identification and radiocarbon analysis. Four of these samples were subsequently submitted for dating and species identification. Bird bones from various locations within a lava tube were collected for identification. Sediment samples for subsequent pollen analysis were obtained from within two lava tubes. With these three sources of information it is hoped that paleoenvironmental data can be recovered that will enable a better understanding of the setting for Hawaiian habitation of the area.

  10. Phase I Archaeological Investigation Cultural Resources Survey, Hawaii Geothermal Project, Makawao and Hana Districts, South Shore of Maui, Hawaii (DRAFT )

    Energy Technology Data Exchange (ETDEWEB)

    Erkelens, Conrad

    1994-03-01

    This report details the archaeological investigation of a 200 foot wide sample corridor extending approximately 9 miles along the southern portion of Maui within the present districts of Hana and Makawao. A total of 51 archaeological sites encompassing 233 surface features were documented. A GPS receiver was used to accurately and precisely plot locations for each of the documented sites. Analysis of the locational information suggests that archaeological sites are abundant throughout the region and only become scarce where vegetation has been bulldozed for ranching activities. At the sea-land transition points for the underwater transmission cable, both Ahihi Bay and Huakini Bay are subjected to seasonal erosion and redeposition of their boulder shorelines. The corridor at the Ahihi Bay transition point runs through the Moanakala Village Complex which is an archaeological site on the State Register of Historic Places within a State Natural Area Reserve. Numerous other potentially significant archaeological sites lie within the project corridor. It is likely that rerouting of the corridor in an attempt to avoid known sites would result in other undocumented sites located outside the sample corridor being impacted. Given the distribution of archaeological sites, there is no alternative route that can be suggested that is likely to avoid encountering sites. A total of twelve charcoal samples were obtained for potential taxon identification and radiocarbon analysis. Four of these samples were subsequently submitted for dating and species identification. Bird bone from various locations within a lava tube were collected for identification. Sediment samples for subsequent pollen analysis were obtained from within two lava tubes. With these three sources of information it is hoped that paleoenvironmental data can be recovered that will enable a better understanding of the setting for Hawaiian habitation of the area. A small test unit was excavated at one habitation site

  11. Hana Aubry et Lia Marcondes (dir.), La culture du risque en question. Des inondations aux débordements nucléaires

    OpenAIRE

    Vauthelin, Éric

    2014-01-01

    Nous vivons dans un monde de plus en plus sûr, mais dans un même temps nous assistons à une prolifération des risques dans notre quotidien. C’est à ce paradoxe que s’attaque cet ouvrage collectif coordonné par Hana Aubry et Lia Marcondes. L’ouvrage interroge les liens entre le risque et le développement des techniques de la société occidentale qui les produit, en même temps qu’elle conceptualise des outils, des dispositifs et des catégories qui prétendent l’en protéger. Outre l’article d’ouve...

  12. Evidence that the hanA gene coding for HU protein is essential for heterocyst differentiation in, and cyanophage A-4(L) sensitivity of, Anabaena sp. strain PCC 7120.

    Science.gov (United States)

    Khudyakov, I; Wolk, C P

    1996-06-01

    The highly pleiotropic, transposon-generated mutant AB22 of Anabaena sp. strain PCC 7120 exhibits slow growth, altered pigmentation, cellular fragility, resistance to phage A-4(L), and the inability to differentiate heterocysts. Reconstruction of the transposon mutation in the wild-type strain reproduced the phenotype of the original mutant. Sequencing of the flanking DNA showed that the transposon had inserted at the beginning of a gene, which we call hanA, that encodes Anabaena HU protein (R. Nagaraja and R. Haselkorn, Biochimie 76:1082-1089, 1994). Mapping of the transposon insertion by pulsed-field gel electrophoresis showed that hanA is located at ca. 4.76 Mb on the physical map of the chromosome and is transcribed clockwise. Repeated subculturing of AB22 resulted in improved growth and loss of filament fragmentation, presumably because of one or more compensatory mutations; however, the mutant retained its A-4(L)r Het- phenotype. The mutation in strain AB22 could be complemented by a fragment of wild-type DNA bearing hanA as its only open reading frame.

  13. SUSE Linux Enterprise Server被选用于SAP HANA

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    SUSE公司于近日宣布,作为与SAP公司(NYSE:SAP)正在进行的合作的一部分,SUSE Linux Enterprise Server已被选用于SAP HANATM。"我们与SAP和IBM的合作已经使数千客户从SUSE Linux所提供的令人兴奋的好处中获益,其中包括操作成本的降低和性能的改进。"SUSE公司全球营销和联盟副总裁Michael Miller说。

  14. Ανάπτυξη εφαρμογών για φορητές συσκευές στο υπολογιστικό νέφος HANA της SAP

    OpenAIRE

    2015-01-01

    Η μεγάλη αύξηση του όγκου των δεδομένων των σύγχρονων πληροφοριακών συστημάτων, σε συνδυασμό με την απαίτηση για άμεση πρόσβαση σε αυτά από όλο και περισσότερους χρήστες και διαφορετικές συσκευές, δημιουργούν μεγάλες καθυστερήσεις που οφείλονται στη συμφόρηση που παρατηρείται στο επίπεδο της Βάσης Δεδομένων. To SAP HANA απαντά σε αυτά τα προβλήματα, αλλάζοντας εντελώς την αρχιτεκτονική του συστήματος βάζοντας τη βάση δεδομένων στη μνήμη (In-Memory), αυξάνοντας κατακόρυφα την απόδοση των συστη...

  15. ESI-HI37 Hana, Island of Maui, Hawaii 2001 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  16. (io\\1ns"if), ifllii/KASH9 (}HANA

    African Journals Online (AJOL)

    Roughly, 70% of ferns are found in tropical climates, while the ... The complexity and difficulty of the classifica- tion of ferns is very ... structure of ferns, such that it is not possible to name one ... typical rainforest but with the increasing rate of.

  17. ПАРАЛЛЕЛЬНЫЕ ВЫЧИСЛЕНИЯ В SAP HANA

    OpenAIRE

    2015-01-01

    Для любого бизнеса актуальна задача эффективного использования операционных данных, накапливаемых в транзакционной системе. Анализ текущих и исторических данных о состоянии организации позволяет руководителям принимать обоснованные, более качественные решения. На предприятиях используются различные способы получения аналитических отчетов. В данной работе рассмотрены следующие подходы к решению этой задачи: реализация аналитического отчета в транзакционной системе, реализация витрины данных, р...

  18. T HE E VALUATION OF F ACTORS I NFLUENCING S AFETY P ERFORMANCE : A C ASE IN AN I NDUSTRIAL G AS M ANUFACTURING C OMPANY (G HANA

    Directory of Open Access Journals (Sweden)

    Evelyn Enchill

    2014-07-01

    Full Text Available Safety has become a very important element in firms and organisations especially in Ghana. The impact of safety factors on a firm’s 3E’s (Employee, Environm ent and Equipment can improve or deteriorate firm’ s public image. This paper identified the key safety indicators and also provided a set of core factors that contribute meaningful in promoting safety performan ce in an Industrial Gas producer in Ghana using the Analytic Hierarchy Process. Organisational, Human, Technical and Environmental factors were identified as the safety indicators in relation to the study a rea. The studies revealed that organisational facto r is the most important factor or criterion that could facil itate a better safety performance of the Industrial Gas Company. In addition, employees was identified the best safety alternative, whilst environment and equipment followed sequentially

  19. C hallenges of M arketing E - banking S ervices in a D eveloping C ountry : T he C ase of G hana

    Directory of Open Access Journals (Sweden)

    B edman N arteh

    2012-08-01

    Full Text Available Even though there is a plethora of studies investigating the challenges of adopting e - banking services, a search through the literature indicates that prior studies have investigated either user adoption challenges or the bank implementation challenges. This study integrate d both perspectives to p rovide a broader conceptual framework for investigating challenges banks face in marketing e - banking services in developing country such as Ghana. The results from the mixed method study indicated that institutional – based challenges as well as user - based challenges affect the marketing of e - banking products in Ghana. The strategic implications of the findings for marketing e - banking services are discussed to guide managers to implement e - banking services in Ghana.

  20. Neli jaapani mängufilmi / Lauri Kitsnik

    Index Scriptorium Estoniae

    Kitsnik, Lauri

    2008-01-01

    Jaapani filmidest: "Elagu filmitegija!" ("Kantoku banzai") rezh. Takeshi Kitano (2007); "Sukiyaki Western Django" rezh. Takashi Miike (2007); "Hana" ("Hana yori mo nao)" rezh. Kore-eda Hirokazu (2006); "Leinav mets" ("Mogari no mori") rezh. Kawase Naomi (2007)

  1. Neli jaapani mängufilmi / Lauri Kitsnik

    Index Scriptorium Estoniae

    Kitsnik, Lauri

    2008-01-01

    Jaapani filmidest: "Elagu filmitegija!" ("Kantoku banzai") rezh. Takeshi Kitano (2007); "Sukiyaki Western Django" rezh. Takashi Miike (2007); "Hana" ("Hana yori mo nao)" rezh. Kore-eda Hirokazu (2006); "Leinav mets" ("Mogari no mori") rezh. Kawase Naomi (2007)

  2. Jaber Hana et Métral France (dir., Mondes en mouvements, Migrants et migrations au Moyen-Orient au tournant du xxie siècle, Institut Français du Proche Orient IFPO, Beyrouth, 2005, 407 p.

    Directory of Open Access Journals (Sweden)

    Fabienne Le Houérou

    2007-07-01

    Full Text Available L’ouvrage se présente comme la publication des résultats d’un programme de recherche, le fruit d’un travail collectif et le texte qui en résulte s’en ressent fortement. Seize auteurs publient les contributions d’un colloque de 2003. L’éventail des migrations qui sont étudiées traduit une grande ambition théorique et empirique. Le livre examine des migrations aussi diverses que les mobilités sous la contrainte du politique, les travailleurs migrants volontaires (avec une insistance particulièr...

  3. ERP Effort Estimation Based on Expert Judgments

    NARCIS (Netherlands)

    Erasmus, I.P.; Daneva, Maia; Demirors, O.; Abran, A.

    2013-01-01

    A new technology shift brings to the ERP domain a change in the industry and a new platform build on in-memory optimized databases, introduced and known as SAP HANA [1]. This technology shift in the ERP domain led to SAP's ERP on HANA, the solution where the ERP suite is offered on the same platform

  4. ERP effort estimation based on expert judgments

    NARCIS (Netherlands)

    Erasmus, Izak Pierre; Daneva, Maya; Demirors, O.; Abran, A.

    2013-01-01

    A new technology shift brings to the ERP domain a change in the industry and a new platform build on in-memory optimized databases, introduced and known as SAP HANA [1]. This technology shift in the ERP domain led to SAP's ERP on HANA, the solution where the ERP suite is offered on the same platform

  5. Three-dimensional Reconstruction of the Microstructure of Human Acellular Nerve Allograft

    Science.gov (United States)

    Zhu, Shuang; Zhu, Qingtang; Liu, Xiaolin; Yang, Weihong; Jian, Yutao; Zhou, Xiang; He, Bo; Gu, Liqiang; Yan, Liwei; Lin, Tao; Xiang, Jianping; Qi, Jian

    2016-01-01

    The exact inner 3D microstructure of the human peripheral nerve has been a mystery for decades. Therefore, it has been difficult to solve several problems regarding peripheral nerve injury and repair. We used high-resolution X-ray computed microtomography (microCT) to scan a freeze-dried human acellular nerve allograft (hANA). The microCT images were then used to reconstruct a 3D digital model, which was used to print a 3D resin model of the nerve graft. The 3D digital model of the hANA allowed visualization of all planes. The magnified 3D resin model clearly showed the nerve bundles and basement membrane tubes of the hANA. Scanning electron microscopy (SEM) was used to analyse the microstructure of the hANA. Compared to the SEM images, the microCT image clearly demonstrated the microstructure of the hANA cross section at a resolution of up to 1.2 μm. The 3D digital model of the hANA facilitates a clear and easy understanding of peripheral nerve microstructure. Furthermore, the enlarged 3D resin model duplicates the unique inner structure of each individual hANA. This is a crucial step towards achieving 3D printing of a hANA or nerve that can be used as a nerve graft. PMID:27476584

  6. Improving Business Intelligence Applications by Using New Generation of Web and Mobile Technologies

    OpenAIRE

    2015-01-01

    The current paper presents an overview about the combination of the new technologies like: SAP HANA, SAP UI5 and SAP Fiori. There are presented the many advantages of which the final user can benefit, such as: fast performance when querying a request, data modelled with the last database innovation of SAP, SAP HANA database, which brings the biggest feature which is in-memory processing. This in-memory computing of SAP HANA enables people to focus on innovation. In the third section are descr...

  7. Improving Business Intelligence Applications by Using New Generation of Web and Mobile Technologies

    Directory of Open Access Journals (Sweden)

    Mihaela-Laura IVAN

    2015-01-01

    Full Text Available The current paper presents an overview about the combination of the new technologies like: SAP HANA, SAP UI5 and SAP Fiori. There are presented the many advantages of which the final user can benefit, such as: fast performance when querying a request, data modelled with the last database innovation of SAP, SAP HANA database, which brings the biggest feature which is in-memory processing. This in-memory computing of SAP HANA enables people to focus on innovation. In the third section are described two examples of web and mobile applications developed with these technologies.

  8. SAP HANA在信息处理领域应用的探讨

    Institute of Scientific and Technical Information of China (English)

    罗保山

    2012-01-01

      SAP HANA 是一个基于“列式存储”及“内存计算技术”的软硬件结合体,通过处理在服务器主存储器上的大量实时数据,获得分析和交易的即时结果,为客户即时洞察、预计未来和行动决策间的贯通提供持续的支持。本文从 SAP HANA 的研究内容、典型应用以及发展等方面出发,对 SAP HANA 应用和发展的基本思想作了介绍,分析了 SAP HANA 应用的优势和可靠性。

  9. 最好的年龄,最好的身材

    Institute of Scientific and Technical Information of China (English)

    郭玉洁; StevenMeisel

    2005-01-01

    Nine modles are featured on the triple-fold cover of Vogue magazine's September 2004 edition. From left are: Daria Werbowy Natalia Vodianova, Gisele Bundchen, Isabeli Fontana,Karolina Kurkova, Liya Kebede, Hana Soukupova, Gemma Ward, and Karen Elson.

  10. Case report

    African Journals Online (AJOL)

    abp

    2017-06-29

    Jun 29, 2017 ... Von Willebrand's disease: case report and review of literature. Hanae Echahdi1 ... glycoprotein crucial for platelet adhesion to the subendothelium after vascular injury. VWD include .... minor surgery including dental work.

  11. 2123-IJBCS-Article-Soro Yayo

    African Journals Online (AJOL)

    hp

    constants, as triglycerides, fatty acids, effects on taste and odour .... were evaluated with naked eye estimating transparency/turbidity of ..... few studies on the plant which established ... Hana K, Jeong YM, Hyeonji K, Dong-Sun L,. Moonjae C ...

  12. Eleventh Annual Report of Accomplishments Under the Airport Improvement Program

    Science.gov (United States)

    1992-01-01

    PLATA COUNTY FIGHTING AND SNOW REMOVAL EQUIPMENT (PRIMARY) BUILDING 11 $249,912 INSTALL TAXIWAY SIGNS AND SECURITY SYSTEM EAGLE 15 $821,200 INSTALL...WORK HAWAI I HANA 02 $20,00O0 CONDUCT MASTER PLAN AND NOISE HANA COMPATIBILITY PLAN STUDIES (COMMERCIAL SERVICE) HILO 03 $1,798,200 CONSTRUCT AIRCRAFT...RESCUE AND FIRE HILO INTERNATIONAL FIGHTING TRAINING FACILITY (PRIMARY) HONOLULU 24 $3,051,170 CONSTRUCT AND LIGHT APRON HONOLULU INTERNATIONAL (PRIMARY

  13. VISAS AND GREEN PLATES

    CERN Multimedia

    2000-01-01

    From 3 April 2000, all questions relating to visa requests for Switzerland, France, or Russia for a member of the personnel must be addressed to Ms. Agnita Querrou (telephone 72838, office 5-2-019, e-mail Agnita.Querrou@cern.ch).The Users' Office continues to deal with requests for letters of invitation and questions concerning visas for users in EP Division.Questions relating to removals, requests for green plates, to privileges of members of the personnel and to the importation of vehicles are still dealt with by Ms Zuzana Miller (telephone 79257, office 33-1-017, e-mail Zuzana.Muller@cern.ch) and Ms Joëlle Belleman (telephone 73962, office 33-1-019, e-mail Joelle.Belleman@cern.ch).

  14. Alignment of high-throughput sequencing data inside in-memory databases.

    Science.gov (United States)

    Firnkorn, Daniel; Knaup-Gregori, Petra; Lorenzo Bermejo, Justo; Ganzinger, Matthias

    2014-01-01

    In times of high-throughput DNA sequencing techniques, performance-capable analysis of DNA sequences is of high importance. Computer supported DNA analysis is still an intensive time-consuming task. In this paper we explore the potential of a new In-Memory database technology by using SAP's High Performance Analytic Appliance (HANA). We focus on read alignment as one of the first steps in DNA sequence analysis. In particular, we examined the widely used Burrows-Wheeler Aligner (BWA) and implemented stored procedures in both, HANA and the free database system MySQL, to compare execution time and memory management. To ensure that the results are comparable, MySQL has been running in memory as well, utilizing its integrated memory engine for database table creation. We implemented stored procedures, containing exact and inexact searching of DNA reads within the reference genome GRCh37. Due to technical restrictions in SAP HANA concerning recursion, the inexact matching problem could not be implemented on this platform. Hence, performance analysis between HANA and MySQL was made by comparing the execution time of the exact search procedures. Here, HANA was approximately 27 times faster than MySQL which means, that there is a high potential within the new In-Memory concepts, leading to further developments of DNA analysis procedures in the future.

  15. Measurement of Nucleate Pool Boiling Heat Transfer Limit using Fuel Cladding Material

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chi Young; Shin, Chang Hwan; Oh, Dong Seok; Chun, Tae Hyun; In, Wang Kee [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    Zircaloy has been widely used as a fuel cladding material of light water reactor for more than three decades because it has a lower neutron absorption cross section and cracking rate. Recently, HANA-6 has been developed in KAERI (Korea Atomic Energy Research Institute) as the advanced fuel cladding for high burn-up fuel. Generally, under the normal and accident operating conditions of a nuclear reactor, the nuclear fuel cladding of zirconium based alloys undergoes the surface change, and the oxide layer can be formed. In such a case, the previous CHF correlations should be assessed and examined using the experimental results for not a fresh zircaloy surface but an oxidized one, to predict and examine the thermal margin and safety of a nuclear reactor core. Therefore, the experimental data using the oxidized zircaloy surface need to be provided quantitatively. In this paper, the CHF in saturated water pool boiling is measured and discussed using the specimens of zircaloy-4, HANA-6, and oxidized zircaloy-4 in high temperature air environment. The CHF of zircaloy-4, HANA-6, and oxidized surface was tested. Zircaloy-4 and HANA-6 had a similar CHF performance. This is because both are the zirconium based alloys, and appear the almost same water contact angle. On the other hands, the oxidized specimen became to be higher CHF than plain zircaloy-4 and HANA-6 specimens, due to smaller water contact angle (i. e., good hydrophilicity of specimen). The Kandlikar's (2001) correlation reasonably predicted the present experimental data.

  16. Characteristics of In-Memory Business Intelligence

    Directory of Open Access Journals (Sweden)

    Mihaela-Laura IVAN

    2014-01-01

    Full Text Available Business Intelligence (BI is an important key in the initiatives of many organizations. BI has developed over the years and the most businesses need to take it to the next level of maturity and improvement can be enabled by SAP HANA. In this paper I presented the evolution of Business Intelligence industry, what others capabilities enterprises still seek and how Business Warehouse on SAP Hana enable these needs. Also, the paper highlights that In-memory Business Intelligence is powerful than data warehouse and Online Analytical Processing projects.

  17. Diffusion tensor imaging in the characterization of multiple system atrophy

    OpenAIRE

    Rulseh AM; Keller J; Rusz J; Syka M; Brozova H; Rusina R; Havrankova P; Zarubova K; Malikova H; Jech R; Vymazal J

    2016-01-01

    Aaron Michael Rulseh,1–3 Jiri Keller,1,4 Jan Rusz,5,6 Michael Syka,1 Hana Brozova,6 Robert Rusina,6,7 Petra Havrankova,6 Katerina Zarubova,8 Hana Malikova,1 Robert Jech,6 Josef Vymazal1 1Department of Radiology, Na Homolce Hospital, Prague, Czech Republic; 2Department of Radiology, 1st Faculty of Medicine, General University Hospital, Charles University in Prague, Prague, Czech Republic; 3National Institute of Mental Health, Klecany, Czech Republic; 43rd Faculty of Medicine, Charle...

  18. Woman in Combat

    Science.gov (United States)

    1988-08-01

    caper was "Nancy Hart’s dinner party". Five 0 Tories, who had just shot a neighbor, forced their way into her home, demanding a meal. Nancy Hart fed... Barbara and Umlauf, Hana. The Good Housekeeping Woman’s Almanan. New York: Newspaper Enterprise Association, Inc., 1977. Miller, Donald L. An Album of

  19. Flacon Avenue

    DEFF Research Database (Denmark)

    Kural, René

    2007-01-01

    Om Omotesando i Tokyo, der er japanernes svar på Champ-Élysées. Her har modehusene Ralph Lauren, Emporio Armani, Hanae Mori, TOD'S, Louis Vuitton, Chanel, FCUK, Gucci, Kenzo, Marina Rinaldi, Fendi, Celine, Donna Karan, Loewe, Issey Miyake, Prada,  Christian Dior, Chloé, Renato Nucci, Dolce...

  20. 76 FR 17471 - Air Tour Management Plan for Haleakala National Park, Maui, HI; Public Meeting/Notice of...

    Science.gov (United States)

    2011-03-29

    ... Federal Aviation Administration Air Tour Management Plan for Haleakala National Park, Maui, HI; Public..., Kahului, HI 96732. Wednesday, April 13, 2011, 5 p.m.-7 p.m. Kula Community Center, 3690 Lower Kula Road, Kula, HI 96790. Thursday, April 14, 2011, 5 p.m.-7 p.m. Helene Community Center (Hana), 150 Keawa...

  1. 75 FR 74732 - Radio Broadcasting Services; AM or FM Proposals To Change The Community of License

    Science.gov (United States)

    2010-12-01

    ... COMMISSION Radio Broadcasting Services; AM or FM Proposals To Change The Community of License AGENCY: Federal..., Facility ID 46969, BPH-20091230AAY, from Titusville, FL, to Deltona, FL; Hawaii Public Radio, Inc., Station KIPM, Facility ID 172438, BMPED-20101019ACS, from Hana, HI, to Waikapu, HI; Huron Broadcasting,...

  2. QTL Information Table: 737 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available itative Trait Loci for White-back and Basal-white Kernels under High Temperature Stress in japonica Rice Varieties. Breeding Science 57, 107-116. ... ...2:3 Hana-echizen Niigatawase A RM4512 RM8208 jsa Kobayashi, A., Genliang, B., Shenghai, Y., and Tomita, K. (2007). Detection of Quant

  3. Estimation of the genetic diversity in tetraploid alfalfa populations based on RAPD markers for breeding purposes.

    Science.gov (United States)

    Nagl, Nevena; Taski-Ajdukovic, Ksenija; Barac, Goran; Baburski, Aleksandar; Seccareccia, Ivana; Milic, Dragan; Katic, Slobodan

    2011-01-01

    Alfalfa is an autotetraploid, allogamous and heterozygous forage legume, whose varieties are synthetic populations. Due to the complex nature of the species, information about genetic diversity of germplasm used in any alfalfa breeding program is most beneficial. The genetic diversity of five alfalfa varieties, involved in progeny tests at Institute of Field and Vegetable Crops, was characterized based on RAPD markers. A total of 60 primers were screened, out of which 17 were selected for the analysis of genetic diversity. A total of 156 polymorphic bands were generated, with 10.6 bands per primer. Number and percentage of polymorphic loci, effective number of alleles, expected heterozygosity and Shannon's information index were used to estimate genetic variation. Variety Zuzana had the highest values for all tested parameters, exhibiting the highest level of variation, whereas variety RSI 20 exhibited the lowest. Analysis of molecular variance (AMOVA) showed that 88.39% of the total genetic variation was attributed to intra-varietal variance. The cluster analysis for individual samples and varieties revealed differences in their population structures: variety Zuzana showed a very high level of genetic variation, Banat and Ghareh were divided in subpopulations, while Pecy and RSI 20 were relatively uniform. Ways of exploiting the investigated germplasm in the breeding programs are suggested in this paper, depending on their population structure and diversity. The RAPD analysis shows potential to be applied in analysis of parental populations in semi-hybrid alfalfa breeding program in both, development of new homogenous germplasm, and identification of promising, complementary germplasm.

  4. Multibeam Bathymetry of Haleakala Volcano, Maui

    Science.gov (United States)

    Eakins, B. W.; Robinson, J.

    2002-12-01

    The submarine northeast flank of Haleakala Volcano, Maui was mapped in detail during the summers of 2001 and 2002 by a joint team from the Japan Marine Science and Technology Center (JAMSTEC), Tokyo Institute of Technology, University of Hawaii, and the U.S. Geological Survey. JAMSTEC instruments used included SeaBeam 2112 hull-mounted multibeam sonar (bathymetry and sidescan imagery), manned submersible Shinkai 6500 and ROV Kaiko (bottom video, photographs and sampling of Hana Ridge), gravimeter, magnetometer, and single-channel seismic system. Hana Ridge, Haleakala's submarine east rift zone, is capped by coral-reef terraces for much of its length, which are flexurally tilted towards the axis of the Hawaiian Ridge and delineate former shorelines. Its deeper, more distal portion exhibits a pair of parallel, linear crests, studded with volcanic cones, that suggest lateral migration of the rift zone during its growth. The northern face of the arcuate ridge terminus is a landslide scar in one of these crests, while its southwestern prong is a small, constructional ridge. The Hana slump, a series of basins and ridges analogous to the Laupahoehoe slump off Kohala Volcano, Hawaii, lies north of Hana Ridge and extends down to the Hawaiian moat. Northwest of this slump region a small, dual-crested ridge strikes toward the Hawaiian moat and is inferred to represent a fossil rift zone, perhaps of East Molokai Volcano. A sediment chute along its southern flank has built a large submarine fan with a staircase of contour-parallel folds on its surface that are probably derived from slow creep of sediments down into the moat. Sediments infill the basins of the Hana slump [Moore et al., 1989], whose lowermost layers have been variously back-tilted by block rotation during slumping and flexural loading of the Hawaiian Ridge; the ridges define the outer edges of those down-dropped blocks, which may have subsided several kilometers. An apron of volcaniclastic debris shed from

  5. Cultura e viaggio. Vergine giurata di Elvira Dones

    Directory of Open Access Journals (Sweden)

    Karp Karol

    2015-12-01

    Full Text Available The aim of the article entitled Culture and journey. Vergine giurata by Elvira Dones is to present the role of two key motives, mentioned in the title, which appear in the work of Elvira Dones. They have a great influence on the life of the main character Hana. The culture demonstrates models which should be imitated and limits her individuality. She has to hide her female identity and to become a man, at least in the eyes of society. Leaving Albany turns out to be the only way of liberation. Hana goes to the United States to get to know herself again. The journey has two significations: the first concerns its fiscal dimension; the second is metaphoric and takes place in the internal world of the character. The analysis is carried out in relation to the concept of body which embraces such elements as sexuality and gender.

  6. 韓国における脱北者の社会適応教育の展開 : 脱北者の社会適応教育施設"ハナ院"を中心に

    OpenAIRE

    尹, 敬勲

    2005-01-01

    In these days, the number of North Korean defectors is increasing as the reason of poverty or human right and so on. Most of them want to settle and live in South Korea. However, as they have lived in a different political, economical and ideological environment since 1945, it is not easy for them to adapt to the social circumstance of South Korea. Therefore, the government of South Korea established an educational institute ("The Hana Institute") for helping what they understand the society ...

  7. Construction of recombinant Marek's disease virus (MDV) lacking the meq oncogene and co-expressing AIV-H9N2 HA and NA genes under control of exogenous promoters.

    Science.gov (United States)

    Zhang, Zhenjie; Chen, Wenqing; Ma, Chengtai; Zhao, Peng; Duan, Luntao; Zhang, Fushou; Sun, Aijun; Li, Yanpeng; Su, Hongqin; Li, Sifei; Cui, He; Cui, Zhizhong

    2014-07-10

    To develop a recombinant Marek's disease virus (rMDV1) co-expressing the hemagglutinin gene (HA) and neuramidinase gene (NA) from a low pathogenic avian influenza virus (LPAIV) H9N2 strain and lacking the meq oncogene that shares homology with the Jun/Fos family of transcriptional factors, a wild strain of MDV GX0101 was used as parental virus, the HA and NA genes co-expression cassette under control of the CMV and SV40 early promoters was inserted at two meq sites of GX0101 to form a new meq knock-out mutant MDV (MZC12HA/NA) through homologous recombination. MZC12HA/NA was reconstituted by transfection of recombinant BAC-MDV DNA into the secondary chicken embryo fibroblast (CEF) cells. Highly purified MZC12HA/NA was obtained after four rounds of plaque purification and proliferation. In vitro growth properties of recombinant virus were also inspected and concluded that the MZC12HA/NA had the same growth kinetics in CEF cultures as its parental wild type virus GX0101. Southern blot indicated that co-expression cassette was successfully inserted at two copies sites of meq gene, so two meq genes were knocked-out completely. RT-qPCR showed transcription and expression levels of the HA and NA genes were both significantly higher than that of GX0101 own pp38 gene. Indirect fluorescence antibody (IFA) test, and Western blot analyses indicated that HA and NA genes were co-expressed simultaneously under control of the different promoters but meq genes were not. These results herald a new and effective recombinant meq-deleted MDV-based AIV-H9N2 vaccine may be useful in protecting chickens from very virulent MDV and H9N2 challenges.

  8. Efficacy and safety of prolonged-release melatonin in insomnia patients with diabetes: a randomized, double-blind, crossover study

    OpenAIRE

    Garfinkel D; Zorin M; Wainstein J; Matas Z; Laudon M; Zisapel N

    2011-01-01

    Doron Garfinkel1, Mariana Zorin2, Julio Wainstein2, Zipora Matas3, Moshe Laudon4, Nava Zisapel4,51Geriatric Palliative Department, Shoham Geriatric Medical Center, Pardes Hana, Israel; 2Diabetes Unit, 3Biochemistry Laboratory, The E Wolfson Medical Center, Holon, Israel; 4Neurim Pharmaceuticals Ltd, 5Department of Neurobiology, Tel Aviv University, Tel Aviv, IsraelBackground: Diabetes is a major comorbidity in insomnia patients. The efficacy and safety of prolonged-release melatonin 2 mg in t...

  9. Bioterrorism Preparedness for Infectious Disease

    Science.gov (United States)

    2005-01-01

    organisms to produce death or disease in humans, animals, or plants (1)). In many ways, the 2001 episode in Hawaii can serve as an interesting...classified as an arbovirus . The A. aegypti mosquito is an urban mosquito that thrives in pools of standing water. Peak transmission is associated with...brochures and mosquito repellent from a tourist information site set up on the road to Hana. Three other roads into the area were closed because of high

  10. Viral fusion efficacy of specific H3N2 influenza virus reassortant combinations at single-particle level

    Science.gov (United States)

    Hsu, Hung-Lun; Millet, Jean K.; Costello, Deirdre A.; Whittaker, Gary R.; Daniel, Susan

    2016-10-01

    Virus pseudotyping is a useful and safe technique for studying entry of emerging strains of influenza virus. However, few studies have compared different reassortant combinations in pseudoparticle systems, or compared entry kinetics of native viruses and their pseudotyped analogs. Here, vesicular stomatitis virus (VSV)-based pseudovirions displaying distinct influenza virus envelope proteins were tested for fusion activity. We produced VSV pseudotypes containing the prototypical X-31 (H3) HA, either alone or with strain-matched or mismatched N2 NAs. We performed single-particle fusion assays using total internal reflection fluorescence microscopy to compare hemifusion kinetics among these pairings. Results illustrate that matching pseudoparticles behaved very similarly to native virus. Pseudoparticles harboring mismatched HA-NA pairings fuse at significantly slower rates than native virus, and NA-lacking pseudoparticles exhibiting the slowest fusion rates. Relative viral membrane HA density of matching pseudoparticles was higher than in mismatching or NA-lacking pseudoparticles. An equivalent trend of HA expression level on cell membranes of HA/NA co-transfected cells was observed and intracellular trafficking of HA was affected by NA co-expression. Overall, we show that specific influenza HA-NA combinations can profoundly affect the critical role played by HA during entry, which may factor into viral fitness and the emergence of new pandemic influenza viruses.

  11. Estimation of the Genetic Diversity in Tetraploid Alfalfa Populations Based on RAPD Markers for Breeding Purposes

    Directory of Open Access Journals (Sweden)

    Slobodan Katic

    2011-08-01

    Full Text Available Alfalfa is an autotetraploid, allogamous and heterozygous forage legume, whose varieties are synthetic populations. Due to the complex nature of the species, information about genetic diversity of germplasm used in any alfalfa breeding program is most beneficial. The genetic diversity of five alfalfa varieties, involved in progeny tests at Institute of Field and Vegetable Crops, was characterized based on RAPD markers. A total of 60 primers were screened, out of which 17 were selected for the analysis of genetic diversity. A total of 156 polymorphic bands were generated, with 10.6 bands per primer. Number and percentage of polymorphic loci, effective number of alleles, expected heterozygosity and Shannon’s information index were used to estimate genetic variation. Variety Zuzana had the highest values for all tested parameters, exhibiting the highest level of variation, whereas variety RSI 20 exhibited the lowest. Analysis of molecular variance (AMOVA showed that 88.39% of the total genetic variation was attributed to intra-varietal variance. The cluster analysis for individual samples and varieties revealed differences in their population structures: variety Zuzana showed a very high level of genetic variation, Banat and Ghareh were divided in subpopulations, while Pecy and RSI 20 were relatively uniform. Ways of exploiting the investigated germplasm in the breeding programs are suggested in this paper, depending on their population structure and diversity. The RAPD analysis shows potential to be applied in analysis of parental populations in semi-hybrid alfalfa breeding program in both, development of new homogenous germplasm, and identification of promising, complementary germplasm.

  12. The PB1 segment of an influenza A virus H1N1 2009pdm isolate enhances the replication efficiency of specific influenza vaccine strains in cell culture and embryonated eggs.

    Science.gov (United States)

    Mostafa, Ahmed; Kanrai, Pumaree; Ziebuhr, John; Pleschka, Stephan

    2016-03-01

    Influenza vaccine strains (IVSs) contain the haemagglutinin (HA) and neuraminidase (NA) genome segments of relevant circulating strains in the genetic background of influenza A/PR/8/1934 virus (PR8). Previous work has shown that the nature of the PB1 segment may be a limiting factor for the efficient production of IVSs. Here, we showed that the PB1 segment (PB1Gi) from the 2009 pandemic influenza A virus (IAV) A/Giessen/06/2009 (Gi wt, H1N1pdm) may help to resolve (some of) these limitations. We produced a set of recombinant PR8-derived viruses that contained (i) the HA and NA segments from representative IAV strains (H3N2, H5N1, H7N9, H9N2); (ii) the PB1 segment from PR8 or Gi wt, respectively; and (iii) the remaining five genome segments from PR8. Viruses containing the PB1Gi segment, together with the heterologous HA/NA segments and five PR8 segments (5+2+1), replicated to higher titres compared with their 6+2 counterparts containing six PR8 segments and the equivalent heterologous HA/NA segments. Compared with PB1PR8-containing IVSs, viruses with the PB1Gi segment replicated to higher or similar titres in both cell culture and embryonated eggs, most profoundly IVSs of the H5N1 and H7N9 subtype, which are known to grow poorly in these systems. IVSs containing either the PB1Gi or the cognate PB1 segment of the respective specific HA/NA donor strain showed enhanced or similar virus replication levels. This study suggests that substitution of PB1PR8 with the PB1Gi segment may greatly improve the large-scale production of PR8-derived IVSs, especially of those known to replicate poorly in vitro.

  13. Two new species of Oxynoemacheilus from the Tigris drainage in Iraqi Kurdistan (Teleostei: Nemacheilidae).

    Science.gov (United States)

    Freyhof, Jörg; Abdullah, Younis Sabir

    2017-03-02

    Two new species of Oxynoemacheilus are described from the Sirvan River drainage in Iraqi Kurdistan. Oxynoemacheilus gyndes, new species, is distinguished by having a very short lateral line, reaching behind the pectoral-fin base, no scales except on the posteriormost part of the caudal peduncle, a slightly emarginate caudal fin and no suborbital groove in males. Oxynoemacheilus hanae, new species, is distinguished by having a midlateral row of elongated blotches, isolated patches of dark-brown spots or blotches on lower flank, a deeply emarginate caudal fin and a suborbital groove in males.

  14. Unification Strategy for North and South Korea: The Most Prudent U.S. Policy Option to Solve the North Korean Nuclear Crisis

    Science.gov (United States)

    2004-09-01

    wonderful wife, Judy; my two precious daughters, Hana and Kara; and my parents , Kwang-hi and Kun-ye for their enduring love and support. x...North or South Koreans, have a deep sense of pride that comes from thousands of years of Confucian heritage. As the Shufeldt mission of 1882 has...it is difficult, if not impossible, to see these policies as ethically or morally principled. Korea was used by the U.S. as a means to an end

  15. Using Business Intelligence Tools for Predictive Analytics in Healthcare System

    Directory of Open Access Journals (Sweden)

    Mihaela-Laura IVAN

    2016-05-01

    Full Text Available The scope of this article is to highlight how healthcare analytics can be improved using Business Intelligence tools. Healthcare system has learned from the previous lessons the necessity of using healthcare analytics for improving patient care, hospital administration, population growth and many others aspects. Business Intelligence solutions applied for the current analysis demonstrate the benefits brought by the new tools, such as SAP HANA, SAP Lumira, and SAP Predictive Analytics. In detailed is analyzed the birth rate with the contribution of different factors to the world.

  16. SAP:寻找数据管理中的“甜点”

    Institute of Scientific and Technical Information of China (English)

    谌力

    2012-01-01

    2012年4月10日,SAP公司发布了与Sybase全面整合后的实时数据平台愿景及创新路线图,以推进公司在数据库和移动应用两大市场的转型和升级。整合后的SAP实时数据平台主要由SAP HANA platform(SAP HANA平台)、Sybase数据管理产品和SAP企业信息管理(EIM)解决方案组成。

  17. Comparison of the reproduction of the goats on the ecological and the conventional farm

    OpenAIRE

    Pravdová, Lenka

    2011-01-01

    The aim of my diploma thesis is comparison and evaluation of reproduction of goats on an eco-farm and on a conventional farm. Measures of reproduction of observed herds were assessed in the years of 2009 and 2010 on an eco-farm Hana Langová and on a conventional farm Bára Schneedorferová. On an eco-farm, a herd of 20 does was observed. Crossbreeds of White shorthaired goat, Brown shorthair goat, Boer goat and Anglo-Nubian goat; all bred with a White shorthaired buck and a Boer buck. On a conv...

  18. A Study of Cardinal Numerals and Pre-nominal Numerals in the Korean Language%朝鲜语基数词的语法功能

    Institute of Scientific and Technical Information of China (English)

    崔惠玲

    2011-01-01

    朝鲜语固有基数词hana()"一"、dul()"二"、set()"三"、net()"四"、sumul ()"二十"有各自对应的冠词形han()、du()、se()、ne()、sumu(),"五"以上原形和冠词形一致.本文重点探讨"数冠词"、"词类通用语"和"变异形态"等说法,试图重新释义数词的语法范畴.

  19. Festivais Matsuris como referencial cultural e turístico da etnia japonesa em Curitiba (Paraná, Brasil

    Directory of Open Access Journals (Sweden)

    Miguel Bahl

    2013-12-01

    Full Text Available O artigo trata sobre Matsuris, festivais da etnia japonesa realizados na cidade de Curitiba, Paraná (Brasil. É um estudo de caso de caráter descritivo com a intenção de resgatar parte do histórico de imigração japonesa no Brasil, a fim de perceber a importância dos festivais Matsuris como referencial da etnia e como forma de inserção social do grupo na capital paranaense. Utilizando pesquisa bibliográfica, busca eletrônica e observação direta intensiva, o estudo traz como resultado a descrição dos três festivais mais importantes da etnia na cidade (Hana Matsuri, Imin Matsuri e Haru Matsuri, demonstrando a relação dos mesmos como referencial étnico japonês e a apresentação do resultado de pesquisa de campo empreendida em 2009, junto ao Hana Matsuri e ao Imin Matsuri. Também evidencia a importância da existência de produtos étnicos culturais para um grupo de imigrantes, principalmente em uma capital cosmopolita como Curitiba, que contemplem o significado real de sua cultura, sem que se tornem apenas um bem de consumo.  Matsuris Festivals as cultural and turistic benchmark of japonese ethnicity in Curitiba (Paraná, Brazil. The article discusses about the Matsuris, Japanese ethnic festivals realized in Curitiba, Paraná (Brazil. It is a descriptive case study that intends to briefly redeem part of the history of Japanese immigration in Brazil, in order to understand the importance of Matsuris festivals as an ethnic referential and as a kind of social insertion of the group at the capital of Paraná. Using literature search, electronic search and intensive direct observation, the study results in a description of the three most important festivals of the ethnic group in the city (Hana Matsuri, Imin Matsuri and Haru Matsuri, showing their relation as an ethnic Japanese referential and showing the result from the field research applied in 2009, during the Hana Matsuri and Imin Matsuri Festivals. It also highlights the

  20. A new species of mesonivirus from the Northern Territory, Australia.

    Science.gov (United States)

    Warrilow, David; Watterson, Daniel; Hall, Roy A; Davis, Steven S; Weir, Richard; Kurucz, Nina; Whelan, Peter; Allcock, Richard; Hall-Mendelin, Sonja; O'Brien, Caitlin A; Hobson-Peters, Jody

    2014-01-01

    Here we describe Casuarina virus (CASV), a new virus in the family Mesoniviridae. This is the first report of a mesonivirus in Australia, which extends the geographical range of this virus family to 3 continents. The virus was isolated in 2010 from Coquillettidia xanthogaster mosquitoes during surveillance in the suburbs of Darwin, the capital of the Northern Territory. Cryo-electron microscopy of the CASV virions revealed spherical particles of 65 nm in size with large club-shaped projections of approximately 15 nm in length. The new virus was most closely related to Alphamesonivirus 1, the only currently recognized species in the family. In 2013 a further 5 putative new mesonivirus species were described: Hana, Méno, Nsé, Moumo and Dak Nong viruses. The evolutionary distance between CASV and two of its closest relatives, Cavally and Hana viruses (Jones-Taylor-Thornton distance of 0.151 and 0.224, respectively), along with its isolation from a different genus of mosquitoes captured on a separate continent indicate that CASV is a new species.

  1. A new species of mesonivirus from the Northern Territory, Australia.

    Directory of Open Access Journals (Sweden)

    David Warrilow

    Full Text Available Here we describe Casuarina virus (CASV, a new virus in the family Mesoniviridae. This is the first report of a mesonivirus in Australia, which extends the geographical range of this virus family to 3 continents. The virus was isolated in 2010 from Coquillettidia xanthogaster mosquitoes during surveillance in the suburbs of Darwin, the capital of the Northern Territory. Cryo-electron microscopy of the CASV virions revealed spherical particles of 65 nm in size with large club-shaped projections of approximately 15 nm in length. The new virus was most closely related to Alphamesonivirus 1, the only currently recognized species in the family. In 2013 a further 5 putative new mesonivirus species were described: Hana, Méno, Nsé, Moumo and Dak Nong viruses. The evolutionary distance between CASV and two of its closest relatives, Cavally and Hana viruses (Jones-Taylor-Thornton distance of 0.151 and 0.224, respectively, along with its isolation from a different genus of mosquitoes captured on a separate continent indicate that CASV is a new species.

  2. Acoustic correlates of Japanese pitch accent

    Science.gov (United States)

    Sugiyama, Yukiko

    2005-09-01

    Acoustic correlates of Japanese pitch accent were investigated using bimoraic/disyllabic pairs of words that are identical except for their accent patterns. For example, /hana/ ``flower'' and /hana/ ``nose'' have the same phonological shape and pitch levels (low-high) yet they differ in that ``flower'' is accented but ``nose'' is unaccented. The most notable acoustic difference between the two accent patterns is realized by the F0 of the following word when there is one. There have been debates about whether the two accent patterns are acoustically different when the following word is excluded. It has been proposed that the F0 maximum is higher, and/or the F0 movement is larger for the accented words. While previous studies used only a few pairs of words, this study tests all 20 pairs of words found by searching a computerized dictionary [Amano and Kondo (1999)] that had a relatively high word familiarity. The F0 maximum and movement were measured in the 20 pairs of words as produced by native speakers of Tokyo Japanese (males and females) in isolation and two frame sentences. Implications of their results for the nature of accent in Japanese and the perception of accent will be discussed.

  3. Components of effective randomized controlled trials of hydrotherapy programs for fibromyalgia syndrome: A systematic review

    Directory of Open Access Journals (Sweden)

    Luke Perraton

    2009-11-01

    Full Text Available Luke Perraton, Zuzana Machotka, Saravana KumarInternational Centre for Allied Health Evidence, University of South Australia, Adelaide, South Australia, AustraliaAim: Previous systematic reviews have found hydrotherapy to be an effective management strategy for fibromyalgia syndrome (FMS. The aim of this systematic review was to summarize the components of hydrotherapy programs used in randomized controlled trials.Method: A systematic review of randomized controlled trials was conducted. Only trials that have reported significant FMS-related outcomes were included. Data relating to the components of hydrotherapy programs (exercise type, duration, frequency and intensity, environmental factors, and service delivery were analyzed.Results: Eleven randomized controlled trials were included in this review. Overall, the quality of trials was good. Aerobic exercise featured in all 11 trials and the majority of hydrotherapy programs included either a strengthening or flexibility component. Great variability was noted in both the environmental components of hydrotherapy programs and service delivery.Conclusions: Aerobic exercise, warm up and cool-down periods and relaxation exercises are common features of hydrotherapy programs that report significant FMS-related outcomes. Treatment duration of 60 minutes, frequency of three sessions per week and an intensity equivalent to 60%–80% maximum heart rate were the most commonly reported exercise components. Exercise appears to be the most important component of an effective hydrotherapy program for FMS, particularly when considering mental health-related outcomes.Keywords: hydrotherapy, fibromyalgia syndrome, exercise, effective, components

  4. A pluralist challenge to "integrative medicine": Feyerabend and Popper on the cognitive value of alternative medicine.

    Science.gov (United States)

    Kidd, Ian James

    2013-09-01

    This paper is a critique of 'integrative medicine' as an ideal of medical progress on the grounds that it fails to realise the cognitive value of alternative medicine. After a brief account of the cognitive value of alternative medicine, I outline the form of 'integrative medicine' defended by the late Stephen Straus, former director of the US National Centre for Complementary and Alternative Medicine. Straus' account is then considered in the light of Zuzana Parusnikova's recent criticism of 'integrative medicine' and her distinction between 'cognitive' and 'opportunistic' engagement with alternative medicine. Parusnikova warns that the medical establishment is guilty of 'dogmatism' and proposes that one can usefully invoke Karl Popper's 'critical rationalism' as an antidote. Using the example of Straus, I argue that an appeal to Popper is insufficient, on the grounds that 'integrative medicine' can class as a form of cognitively-productive, critical engagement. I suggest that Parusnikova's appeal to Popper should be augmented with Paul Feyerabend's emphasis upon the role of 'radical alternatives' in maximising criticism. 'Integrative medicine' fails to maximise criticism because it 'translates' alternative medicine into the theories and terminology of allopathic medicine and so erodes its capacity to provide cognitively-valuable 'radical alternatives'. These claims are then illustrated with a discussion of 'traditional' and 'medical' acupuncture. I conclude that 'integrative medicine' fails to exploit the cognitive value of alternative medicine and so should be rejected as an ideal of medical progress.

  5. Direct thrombolysis of multiple thrombi in both right and left heart atrium in a patient on extracorporeal membrane oxygenation support following urgent double-lung transplantation: a case report

    Directory of Open Access Journals (Sweden)

    Pollert L

    2016-06-01

    Full Text Available Lukas Pollert,1 Zuzana Prikrylova,1 Jan Berousek,1 Frantisek Mosna,1 Robert Lischke2 1Department of Anaesthesiology and Intensive Care, 2nd Faculty of Medicine, 23rd Surgical Department, 1st Faculty of Medicine, Charles University in Prague and Motol University Hospital, Praha, Czech Republic Background: Lung transplantation is considered an established treatment for patients with end-stage chronic respiratory failure. Patients with acute respiratory failure requiring respiratory support with invasive mechanical ventilation while awaiting lung transplantation are at high risk of death. Extracorporeal membrane oxygenation (ECMO has been proposed as an alternative bridging strategy to mechanical ventilation. The shear stress created by the mechanical pumps causes changes in the hematological system in almost all patients treated with ECMO. An antithrombotic strategy to mitigate ECMO bleeding and thrombotic complications is necessary. The use of thrombolytic therapy is recommended for patients with acute symptomatic embolism with associated hypotension or shock. In this setting, the hemodynamic benefits of thrombolytic treatment far outweigh its bleeding risk.Case presentation: This case report describes a 32-year-old woman suffering from lymphangioleiomyomatosis, who underwent urgent double-lung transplantation. This patient was maintained on ECMO preoperatively, perioperatively, and postoperatively due to life-threatening hypoxemia caused by the progression of her pulmonary tissue damage. Multiple thrombi developed in the early postoperative period, in both right and left heart atria. Direct thrombolysis was successfully performed on the first postoperative day.Conclusion: According to the current published literature, direct thrombolysis of thrombi in both right and left atria in a patient supported on ECMO following urgent double-lung transplantation is an extremely rare treatment method. Even when taking into account all of the risks

  6. Expanded DMPK repeats in dizygotic twins referred for diagnosis of autism versus absence of expanded DMPK repeats at screening of 330 children with autism

    Directory of Open Access Journals (Sweden)

    Musova Z

    2016-09-01

    Full Text Available Zuzana Musova,1 Miroslava Hancarova,1 Marketa Havlovicova,1 Radka Pourova,1 Michal Hrdlicka,2 Josef Kraus,3 Marie Trkova,4 David Stejskal,4 Zdenek Sedlacek1 1Department of Biology and Medical Genetics, 2Department of Child Psychiatry, 3Department of Child Neurology, Charles University 2nd Faculty of Medicine and University Hospital Motol, 4Gennet, Centre for Fetal Medicine, Prague, Czech Republic Abstract: Myotonic dystrophy type 1 (DM1 belongs to the broad spectrum of genetic disorders associated with autism spectrum disorders (ASD. ASD were reported predominantly in congenital and early childhood forms of DM1. We describe dizygotic twin boys with ASD who were referred for routine laboratory genetic testing and in whom karyotyping, FMR1 gene testing, and single nucleotide polymorphism array analysis yielded negative results. The father of the boys was later diagnosed with suspected DM1, and testing revealed characteristic DMPK gene expansions in his genome as well as in the genomes of both twins and their elder brother, who also suffered from ASD. In accord with previous reports on childhood forms of DM1, our patients showed prominent neuropsychiatric phenotypes characterized especially by hypotonia, developmental and language delay, emotional and affective lability, lowered adaptability, and social withdrawal. The experience with this family and multiple literature reports of ASD in DM1 on the one side but the lack of literature data on the frequency of DMPK gene expansions in ASD patients on the other side prompted us to screen the DMPK gene in a sample of 330 patients with ASD who were first seen by a geneticist before they were 10 years of age, before the muscular weakness, which may signal DM1, usually becomes obvious. The absence of any DMPK gene expansions in this cohort indicates that targeted DMPK gene testing can be recommended only in ASD patients with specific symptoms or family history suggestive of DM1. Keywords: autism, myotonic

  7. Coping strategies, hope, and treatment efficacy in pharmacoresistant inpatients with neurotic spectrum disorders

    Directory of Open Access Journals (Sweden)

    Ociskova M

    2015-05-01

    Full Text Available Marie Ociskova,1,2 Jan Prasko,2 Dana Kamaradova,2 Ales Grambal,2 Petra Kasalova,2 Zuzana Sigmundova,2 Klara Latalova,2 Kristyna Vrbova2 1Department of Psychology, Faculty of Arts, 2Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, Czech Republic Background: Approximately 30%–60% of patients with neurotic spectrum disorders remain symptomatic despite treatment. Identifying the predictors of good response to psychiatric and psychotherapeutic treatment may be useful for increasing treatment efficacy in neurotic patients. The objective of this study was to investigate the influence of hope, coping strategies, and dissociation on the treatment response of this group of patients.Methods: Pharmacoresistant patients, who underwent a 6-week psychotherapeutic program, were enrolled in the study. All patients completed the Clinical Global Impression (CGI – both objective and subjective forms, Beck Anxiety Inventory (BAI, and Beck Depression Inventory (BDI-II at baseline and after 6 weeks. The COPE Inventory, the Adult Dispositional Hope Scale (ADHS, and the Dissociative Experiences Scale (DES were completed at the start of the treatment.Results: Seventy-six patients completed the study. The mean scores for all scales measuring the severity of the disorders (BAI, BDI-II, subjective and objective CGI significantly decreased during the treatment. Several subscores of the COPE Inventory, the overall score of ADHS, and the overall score of DES significantly correlated with the treatment outcome. Multiple regression was used to find out which factors were the most significant predictors of the therapeutic outcomes. The most important predictors of the treatment response were the overall levels of hope and dissociation.Conclusion: According to our results, a group of patients with a primary neurotic disorder, who prefer the use of maladaptive coping strategies, feel hopelessness, and

  8. Controlled gentamicin release from multi-layered electrospun nanofibrous structures of various thicknesses

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    Sirc J

    2012-10-01

    Full Text Available Jakub Sirc,1 Sarka Kubinova,2 Radka Hobzova,1 Denisa Stranska,3 Petr Kozlik,4 Zuzana Bosakova,4 Dana Marekova,2 Vladimir Holan,5 Eva Sykova,2 Jiri Michalek11Department of Polymer Gels, Institute of Macromolecular Chemistry, Academy of Science of the Czech Republic, Prague, Czech Republic; 2Department of Neuroscience, Institute of Experimental Medicine, Academy of Science of the Czech Republic, Prague, Czech Republic; 3Elmarco Ltd, Liberec, Czech Republic; 4Department of Analytical Chemistry, Faculty of Science, Charles University in Prague, Prague, Czech Republic; 5Department of Transplant Immunology, Institute of Molecular Genetics, Academy of Science of the Czech Republic, Prague, Czech RepublicAbstract: Polyvinyl alcohol nanofibers incorporating the wide spectrum antibiotic gentamicin were prepared by Nanospider™ needleless technology. A polyvinyl alcohol layer, serving as a drug reservoir, was covered from both sides by polyurethane layers of various thicknesses. The multilayered structure of the nanofibers was observed using scanning electron microscopy, the porosity was characterized by mercury porosimetry, and nitrogen adsorption/desorption measurements were used to determine specific surface areas. The stability of the gentamicin released from the electrospun layers was proved by high-performance liquid chromatography (HPLC and inhibition of bacterial growth. Drug release was investigated using in vitro experiments with HPLC/MS quantification, while the antimicrobial efficacy was evaluated on Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa. Both experiments proved that the released gentamicin retained its activity and showed that the retention of the drug in the nanofibers was prolonged with the increasing thickness of the covering layers.Keywords: nanofibers, electrospinning, multilayered structure, morphology, gentamicin, drug release

  9. Development and implementation of an online hybrid model for teaching evidence-based practice to health professions: processes and outcomes from an Australian experience

    Directory of Open Access Journals (Sweden)

    Saravana Kumar

    2010-08-01

    Full Text Available Saravana Kumar, Luke Perraton, Zuzana Machotka.International Centre for Allied Health Evidence, School of Health Sciences, University of South Australia, Adelaide, South Australia.Abstract: Evidence-based practice is now considered to be a vital element of health care service delivery. The call to use evidence to inform other areas, such as teaching and learning, is growing. This paper reports on the processes used to integrate best evidence into teaching practices within an undergraduate health science program. An existing course within this program at an Australian tertiary institution was remodeled by a newly appointed course coordinator in response to critical feedback from student cohorts. A systematic, iterative, five-step approach was used in the development of the new course. The process of development was influenced by current research evidence, an audit of the existing course, and critical feedback from ­students. The new course was evaluated using quantitative and qualitative research methods for five study periods. In 2005, prior to implementing the changes, the overall student satisfaction rating for the course was zero (representing the lowest possible score. In 2006, the overall student satisfaction rating was 62.07, in 2007 it was 65.8, and in 2008 it was 55.7. Qualitative ­findings also supported these quantitative findings, indicating improvements in the structure and process of the new course. The outcomes from the evaluation of the remodeled course provide evidence of a consistent quality learning experience for students, and support the concept of using research evidence to guide the development of teaching and learning practices in the training of health professionals.Keywords: evidence-based teaching, learning, health care, qualitative, quantitative.

  10. Coronal Dynamics at Recent Total Solar Eclipses

    Science.gov (United States)

    Pasachoff, J. M.; Lu, M.; Davis, A. B.; Demianski, M.; Rusin, V.; Saniga, M.; Seaton, D. B.; Lucas, R.; Babcock, B. A.; Dantowitz, R.; Gaintatzis, P.; Seeger, C. H.; Malamut, C.; Steele, A.

    2014-12-01

    Our composite images of the solar corona based on extensive imaging at the total solar eclipses of 2010 (Easter Island), 2012 (Australia), and 2013 (Gabon) reveal several coronal mass ejections and other changes in coronal streamers and in polar plumes. Our resultant spatial resolution is finer than that available in imaging from spacecraft, including that from SOHO/LASCO or STEREO. We trace the eruptions back to their footpoints on the sun using imaging from SDO and SWAP, and follow them upwards through the corona, measuring velocities. The high-resolution computer compositing by Miloslav Druckmüller and Hana Druckmüllerová (2010 and 2013) and Pavlos Gaintatzis (2012) allows comparison of our images with those taken at intervals of minutes or hours along the totality path. Williams College's 2013 eclipse expedition was supported in part by grant 9327-13 from National Geographic Society/Committee for Research and Exploration. Our work on the 2012 eclipse is supported in part by grant AGS-1047726 from Solar Terrestrial Research/NSF AGS. V.R. and M.S. were partially supported by the VEGA grant agency project 2/0098/10 and 2/0003/13 (Slovak Academy of Sciences) and Grant 0139-12 from NG/CRE, and Hana Druckmüllerová by grant 205/09/1469 of the Czech Science Foundation. M.L. was supported by Sigma Xi. C.M. was a Keck Northeast Astronomy Consortium Summer Fellow, supported at Williams College by REU/NSF grant AST-1005024. Partial support was provided by U.S. Department of Defense's ASSURE program. J.M.P. thanks Caltech's Planetary Sciences Department for hospitality. Support for D.B.S. and SWAP came from PRODEX grant C90345 managed by ESA in collaboration with the Belgian Federal Science Policy Office (BELSPO) in support of the PROBA2/SWAP mission, and from the EC's Seventh Framework Programme (FP7/2007-2013) under grant 218816 (SOTERIA project, www.soteria-space.eu). SWAP is a project of the Centre Spatial de Liège and the Royal Observatory of Belgium funded by

  11. Diffusion tensor imaging in the characterization of multiple system atrophy

    Directory of Open Access Journals (Sweden)

    Rulseh AM

    2016-08-01

    Full Text Available Aaron Michael Rulseh,1–3 Jiri Keller,1,4 Jan Rusz,5,6 Michael Syka,1 Hana Brozova,6 Robert Rusina,6,7 Petra Havrankova,6 Katerina Zarubova,8 Hana Malikova,1 Robert Jech,6 Josef Vymazal1 1Department of Radiology, Na Homolce Hospital, Prague, Czech Republic; 2Department of Radiology, 1st Faculty of Medicine, General University Hospital, Charles University in Prague, Prague, Czech Republic; 3National Institute of Mental Health, Klecany, Czech Republic; 43rd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic; 5Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic; 6Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic; 7Thomayer Hospital, Prague, Czech Republic; 8Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic Purpose: Multiple system atrophy (MSA is a rare neurodegenerative disease that remains poorly understood, and the diagnosis of MSA continues to be challenging. We endeavored to improve the diagnostic process and understanding of in vivo characteristics of MSA by diffusion tensor imaging (DTI.Materials and methods: Twenty MSA subjects, ten parkinsonian dominant (MSA-P, ten cerebellar dominant (MSA-C, and 20 healthy volunteer subjects were recruited. Fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity maps were processed using tract-based spatial statistics. Diffusion data were additionally evaluated in the basal ganglia. A support vector machine was used to assess diagnostic utility, leave-one-out cross-validation in the evaluation of classification schemes, and receiver operating characteristic analyses to determine cutoff values.Results: We detected widespread changes in the brain white matter of MSA subjects; however, no group-wise differences were found between MSA-C and MSA

  12. Neuraminidase and hemagglutinin matching patterns of a highly pathogenic avian and two pandemic H1N1 influenza A viruses.

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    Yonghui Zhang

    Full Text Available BACKGROUND: Influenza A virus displays strong reassortment characteristics, which enable it to achieve adaptation in human infection. Surveying the reassortment and virulence of novel viruses is important in the prevention and control of an influenza pandemic. Meanwhile, studying the mechanism of reassortment may accelerate the development of anti-influenza strategies. METHODOLOGY/PRINCIPAL FINDINGS: The hemagglutinin (HA and neuraminidase (NA matching patterns of two pandemic H1N1 viruses (the 1918 and current 2009 strains and a highly pathogenic avian influenza A virus (H5N1 were studied using a pseudotyped particle (pp system. Our data showed that four of the six chimeric HA/NA combinations could produce infectious pps, and that some of the chimeric pps had greater infectivity than did their ancestors, raising the possibility of reassortment among these viruses. The NA of H5N1 (A/Anhui/1/2005 could hardly reassort with the HAs of the two H1N1 viruses. Many biological characteristics of HA and NA, including infectivity, hemagglutinating ability, and NA activity, are dependent on their matching pattern. CONCLUSIONS/SIGNIFICANCE: Our data suggest the existence of an interaction between HA and NA, and the HA NA matching pattern is critical for valid viral reassortment.

  13. Surveillance and Outbreak Response Management System (SORMAS) to support the control of the Ebola virus disease outbreak in West Africa.

    Science.gov (United States)

    Fähnrich, C; Denecke, K; Adeoye, O O; Benzler, J; Claus, H; Kirchner, G; Mall, S; Richter, R; Schapranow, M P; Schwarz, N; Tom-Aba, D; Uflacker, M; Poggensee, G; Krause, G

    2015-03-26

    In the context of controlling the current outbreak of Ebola virus disease (EVD), the World Health Organization claimed that 'critical determinant of epidemic size appears to be the speed of implementation of rigorous control measures', i.e. immediate follow-up of contact persons during 21 days after exposure, isolation and treatment of cases, decontamination, and safe burials. We developed the Surveillance and Outbreak Response Management System (SORMAS) to improve efficiency and timeliness of these measures. We used the Design Thinking methodology to systematically analyse experiences from field workers and the Ebola Emergency Operations Centre (EOC) after successful control of the EVD outbreak in Nigeria. We developed a process model with seven personas representing the procedures of EVD outbreak control. The SORMAS system architecture combines latest In-Memory Database (IMDB) technology via SAP HANA (in-memory, relational database management system), enabling interactive data analyses, and established SAP cloud tools, such as SAP Afaria (a mobile device management software). The user interface consists of specific front-ends for smartphones and tablet devices, which are independent from physical configurations. SORMAS allows real-time, bidirectional information exchange between field workers and the EOC, ensures supervision of contact follow-up, automated status reports, and GPS tracking. SORMAS may become a platform for outbreak management and improved routine surveillance of any infectious disease. Furthermore, the SORMAS process model may serve as framework for EVD outbreak modeling.

  14. 联想携手SAP打造全新商业智能

    Institute of Scientific and Technical Information of China (English)

    吴加录

    2012-01-01

    在刚刚结束的SAP商业同略会上,SAP公布了其德国实验室的最新测试结果:联想R680 G7高端四路服务器成功通过了SAP HANA(高性能分析应用软件,High-Performance Analytic Appliance)测试.由此,联想将成为SAP第一家源于中国的技术合作伙伴,可以在中国开始基于HANA解决方案的硬件营销工作,将这一基于内存计算(In-Memory Computing)全新理念的软硬件一体化解决方案带给全球更多企业用户,为用户带来更高效率、更低成本、更易管理的数据仓库系统.

  15. Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis

    Directory of Open Access Journals (Sweden)

    Payne CM

    2011-05-01

    Full Text Available Claire M Payne, Cheray Crowley-Skillicorn, Carol Bernstein, Hana Holubec, Harris BernsteinDepartment of Cell Biology and Anatomy, College of Medicine, University of Arizona Tucson, AZ, USAAbstract: Chromosomal instability is a major pathway of sporadic colon carcinogenesis. Chromosome arm 1p appears to be one of the “hot spots” in the non-neoplastic mucosa that, when deleted, is associated with the initiation of carcinogenesis. Chromosome arm 1p contains genes associated with DNA repair, spindle checkpoint function, apoptosis, multiple microRNAs, the Wnt signaling pathway, tumor suppression, antioxidant activities, and defense against environmental toxins. Loss of 1p is dangerous since it would likely contribute to genomic instability leading to tumorigenesis. The 1p deletion-associated colon carcinogenesis pathways are reviewed at the molecular and cellular levels. Sporadic colon cancer is strongly linked to a high-fat/low-vegetable/low-micronutrient, Western-style diet. We also consider how selected dietary-related compounds (eg, excess hydrophobic bile acids, and low levels of folic acid, niacin, plant-derived antioxidants, and other modulatory compounds might affect processes leading to chromosomal deletions, and to the molecular and cellular pathways specifically altered by chromosome 1p loss.Keywords: chromosome 1p, colon carcinogenesis, molecular pathways, cellular pathways

  16. Cinematic shots and cuts: on the ethics and semiotics of real violence in film fiction

    Directory of Open Access Journals (Sweden)

    Erik van Ooijen

    2011-05-01

    Full Text Available In this article I discuss a few ethical and semiotic problems related to reality's ability to actually take place within, and break through, fictional representations. I am particularly concerned with the presence of material bodies in the performing arts. I consider Hideshi Hino's Flower of Flesh and Blood (Ginî piggu 2: Chiniku no hana, 1985 as an initial example of purely fictional film violence. From a brief presentation of traditional theatre semiotics and the concept of a fictive stance, I then discuss two specific films where the body of the actor functions not only as the carrier of symbolical meaning but also as an indexical reference to a factual situation: John Waters’ Pink Flamingos (1972 and Ruggero Deodato's Cannibal Holocaust (1980. My main interest lies in the occurrence of real violence, and particularly animal killings, in exploitation cinema. By considering directors’ own statements on the matter, I suggest that such violence can not simply be dismissed as ethically flawed; rather, it carries a potential critique of the ideology of meat as pure commodity.

  17. Workspace and rotational capability analysis of a spatial 3-DoF parallel manipulator

    Institute of Scientific and Technical Information of China (English)

    LIU Xinjun; WANG Jinsong; WANG Qiming; LI Tiemin

    2004-01-01

    The analysis on the workspace and rotational capability of HANA, a spatial 3-DoF parallel manipulator, is concerned. The parallel manipulator consists of a base plate, a movable platform, and three connecting legs. The moving platform has three degrees of freedom (DoFs) which are two translations and one rotation, with respect to the base plate. The new parallel manipulator is very interesting for the reason of no singularity in the workspace, the single-DoF joint architecture and high rotational capability of the moving platform. The inverse kinematics problem is described in a closed-form, which is very useful to present the workspace geometrically. The constant-orientation and reachable workspaces for the manipulator are analyzed firstly. The index that is used to evaluate the rotational capability of the manipulator is defined and discussed in detail. Finally, the distribution of rotational capability index on the workspace is presented, which helps us know how much the index is at different point. The parallel manipulator has wide application in the fields of industrial robots, simulators, micro-motion manipulators, and parallel kinematics machines.

  18. Salvage therapies in relapsed and/or refractory myeloma: what is current and what is the future?

    Directory of Open Access Journals (Sweden)

    Thumallapally N

    2016-08-01

    Full Text Available Nishitha Thumallapally,1 Hana Yu,1 Divya Asti,1 Adarsh Vennepureddy,1 Terenig Terjanian2 1Department of Internal Medicine, 2Division of Hematology and Oncology, Staten Island University Hospital, New York, NY, USA Abstract: The treatment landscape for multiple myeloma (MM is evolving with our understanding of its pathophysiology. However, given the inevitable cohort heterogeneity in salvage therapy, response to treatment and overall prognoses tend to vary widely, making meaningful conclusions about treatment efficacy difficult to derive. Despite the hurdles in current research, progress is underway toward more targeted therapeutic approaches. Several new drugs with novel mechanism of action and less toxic profile have been developed in the past decade, with the potential for use as single agents or in synergy with other treatment modalities in MM therapy. As our discovery of these emerging therapies progresses, so too does our need to reshape our knowledge on knowing how to apply them. This review highlights some of the recent landmark changes in MM management with specific emphasis on salvage drugs available for relapsed and refractory MM and also discusses some of the upcoming cutting-edge therapies that are currently in various stages of clinical development. Keywords: multiple myeloma, novel drugs, relapsed and refractory myeloma, salvage chemotherapy 

  19. Hendra and Nipah viruses: pathogenesis, animal models and recent breakthroughs in vaccination

    Directory of Open Access Journals (Sweden)

    Weingartl HM

    2015-09-01

    Full Text Available Hana M Weingartl National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB, Canada Abstract: Hendra and Nipah viruses are two highly pathogenic zoonotic members of the genus Henipavirus, family Paramyxoviridae, requiring work under biosafety level 4 conditions due to a lack of effective therapy and human vaccines. Several vaccine candidates were protective in animal models: recombinant vaccinia virus expressing Nipah virus (NiV F and G proteins in hamsters against NiV; recombinant ALVAC–NiV F and G in swine against NiV; recombinant Hendra virus (HeV soluble G protein (sGHeV against HeV and NiV in cats, ferrets, horses, and African green monkeys (AGM; recombinant vesicular stomatitis virus-based vectors expressing NiV F or G against NiV in hamsters and ferrets; measles virus-based NiV G vaccine candidate in hamsters and AGMs against NiV; and adenoassociated virus expressing NiG protein, which protected hamsters against NiV. The sGHeV was licensed for use in horses (Equivac HeV® in 2012. It is the first vaccine candidate licensed against a biosafety level 4 agent. With the development of suitable animal models (ferret, hamster and, importantly, AGM, progress can be made toward development of a human vaccine.Keywords: henipavirus, equine, swine, human infection, animal models, vaccine candidates

  20. Þörf og mikilvægi skipulagðrar foreldrafræðslu: könnun innan Heilbrigðisstofnunar Austurlands

    OpenAIRE

    Birna Sigurveig Björnsdóttir; Heiðdís Harpa Kristjánsdóttir; Ólína Ágústa Sófusdóttir

    2002-01-01

    Tilgangur rannsóknarinnar var að kanna þörf fyrir skipulagða foreldrafræðslu innan Heilbrigðisstofnunar Austurlands og var gerð að beiðni stjórnenda hennar. Skipulögð foreldrafræðsla er fræðsla utan mæðraverndar þar sem ljósmæður, læknar, hjúkrunarfræðingar og annað heilbrigðisstarfsfólk sér um hana. Markmið hennar er að hjálpa foreldrum að ná tökum á þeim breytingum sem fylgja meðgöngu, fæðingu og umönnun nýburans. Í rannsóknum hefur komið fram að þeir foreldrar sem fengu skipulagða foreldra...

  1. A vesicular stomatitis pseudovirus expressing the surface glycoproteins of influenza A virus.

    Science.gov (United States)

    Cheresiz, S V; Kononova, A A; Razumova, Yu V; Dubich, T S; Chepurnov, A A; Kushch, A A; Davey, R; Pokrovsky, A G

    2014-10-01

    Pseudotyped viruses bearing the glycoprotein(s) of a donor virus over the nucleocapsid core of a surrogate virus are widely used as safe substitutes for infectious virus in virology studies. Retroviral particles pseudotyped with influenza A virus glycoproteins have been used recently for the study of influenza hemagglutinin and neuraminidase-dependent processes. Here, we report the development of vesicular-stomatitis-virus-based pseudotypes bearing the glycoproteins of influenza A virus. We show that pseudotypes bearing the hemagglutinin and neuraminidase of H5N1 influenza A virus mimic the wild-type virus in neutralization assays and sensitivity to entry inhibitors. We demonstrate the requirement of NA for the infectivity of pseudotypes and show that viruses obtained with different NA proteins are significantly different in their transduction activities. Inhibition studies with oseltamivir carboxylate show that neuraminidase activity is required for pseudovirus production, but not for the infection of target cells with H5N1-VSV pseudovirus. The HA-NA-VSV pseudoviruses have high transduction titers and better stability than the previously reported retroviral pseudotypes and can replace live influenza virus in the development of neutralization assays, screening of potential antivirals, and the study of different HA/NA reassortants.

  2. Nicoboxil/nonivamide cream effectively and safely reduces acute nonspecific low back pain – a randomized, placebo-controlled trial

    Directory of Open Access Journals (Sweden)

    Blahova Z

    2016-12-01

    Full Text Available Zuzana Blahova,1 Janina Claudia Holm,1 Thomas Weiser,2 Erika Richter,2 Matthias Trampisch,2 Elena Akarachkova3 1Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; 2Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim am Rhein, Germany; 3I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation Background/objective: Low back pain affects many patients and has a high socioeconomic impact. Topical capsaicinoids have been used for decades to treat musculoskeletal pain. This study investigated the effects of the fixed dose combination (FDC of nonivamide (a capsaicinoid and nicoboxil (a nicotinic acid ester cream in the treatment of acute nonspecific low back pain.Materials and methods: This phase III randomized, double-blind, placebo-controlled, multinational, multi-center trial investigated efficacy, safety, and tolerability of topical nicoboxil 1.08%/nonivamide 0.17% (Finalgon® cream in treatment of acute nonspecific low back pain with the endpoints: pain intensity (PI difference between pre-dose baseline and 8 hours after first application and the end of treatment, mobility score, and efficacy score.Results: Patients (n=138, 21–65 years of age, were treated for up to 4 days with FDC or placebo cream. Mean baseline PI was 6.8 on a 0–10 point numerical rating scale. After 8 hours, pain was more reduced with the FDC than with placebo (adjusted means: 2.824 vs. 0.975 points; p<0.0001. On the last treatment day, mean pain reduction by the FDC was stronger than with placebo (adjusted means: 5.132 vs. 2.174 points; p<0.0001. Mobility on Day 1 was in favor of the FDC when compared to placebo (odds ratio [95% confidence interval {CI}]: 7.200 [3.609, 14.363], p<0.0001. At the end of treatment, patients treated with the FDC rated efficacy significantly higher than placebo (odds ratio [95% CI]: 11.370 [5.342, 24.199], p<0.0001. Both treatments were tolerated well. No serious adverse events were reported.Conclusion: Nicoboxil

  3. Individual correlates of self-stigma in patients with anxiety disorders with and without comorbidities

    Directory of Open Access Journals (Sweden)

    Ociskova M

    2015-07-01

    Full Text Available Marie Ociskova,1,2 Jan Prasko,1 Dana Kamaradova,1 Ales Grambal,1 Zuzana Sigmundova1 1Department of Psychiatry, University Hospital in Olomouc, Faculty of Medicine and Dentistry, 2Department of Psychology, Faculty of Arts, Palacky University in Olomouc, Olomouc, Czech Republic Background: A number of psychiatric patients experience stigma connected to prejudices about mental disorders. It has been shown that stigma is most harmful when it is internalized. Most of the studies were performed on individuals either with psychoses or with mood disorders, and hence, there are almost no studies with other diagnostic categories. The goals of this research were to identify factors that are significantly related to self-stigma in patients with anxiety disorders and to suggest possible models of causality for these relationships.Methods: A total of 109 patients with anxiety disorders and possible comorbid depressive or personality disorders, who were admitted to the psychotherapeutic department participated in this study. All patients completed several psychodiagnostic methods, ie, the Internalized Stigma of Mental Illness Scale, Temperament and Character Inventory-Revised Version, Adult Dispositional Hope Scale, Dissociative Experiences Scale, Beck Anxiety Inventory, Beck Depression Inventory-Second Edition, and Clinical Global Impression (also completed by the senior psychiatrist.Results: The overall level of self-stigma was positively associated with a comorbid personality disorder, more severe symptomatology, more intense symptoms of anxiety and depression, and higher levels of dissociation and harm avoidance. Self-stigma was negatively related to hope, reward dependence, persistence, self-directedness, and cooperativeness. Multiple regression analysis showed that the most significant factors connected to self-stigma are harm avoidance, the intensity of depressive symptoms, and self-directedness. Two models of causality were proposed and validated. It

  4. Diagnosing COPD: advances in training and practice – a systematic review

    Directory of Open Access Journals (Sweden)

    Koblizek V

    2016-04-01

    Full Text Available Vladimir Koblizek,1,2 Barbora Novotna,1–3 Zuzana Zbozinkova,3 Karel Hejduk31Department of Pneumology, University Hospital Hradec Kralove, Hradec Králové, Czech Republic; 2Faculty of Medicine in Hradec Kralove, Charles University in Prague, Hradec Králové, Czech Republic; 3Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech RepublicAbstract: Chronic obstructive pulmonary disease (COPD is a chronic inflammatory lung syndrome, caused by long-term inhalation of noxious gases and particles, which leads to gradual airflow limitation. All health care professionals who care for COPD patients should have full access to high-quality spirometry testing, as postbronchodilator spirometry constitutes the principal method of COPD diagnosis. One out of four smokers 45 years or older presenting respiratory symptoms in primary care, have non-fully reversible airflow limitation compatible with COPD and are mostly without a known diagnosis. Approximately 50.0%–98.3% of patients are undiagnosed worldwide. The majority of undiagnosed COPD patients are isolated at home, are in nursing or senior-assisted living facilities, or are present in oncology and cardiology clinics as patients with lung cancers and coronary artery disease. At this time, the prevalence and mortality of COPD subjects is increasing, rapidly among women who are more susceptible to risk factors. Since effective management strategies are currently available for all phenotypes of COPD, correctly performed and well-interpreted postbronchodilator spirometry is still an essential component of all approaches used. Simple educational training can substantially improve physicians’ knowledge relating to COPD diagnosis. Similarly, a physician inhaler education program can improve attitudes toward inhaler teaching and facilitate its implementation in routine clinical practices. Spirometry combined with inhaled technique education improves the ability of

  5. Osteogenic cell differentiation on H-terminated and O-terminated nanocrystalline diamond films

    Directory of Open Access Journals (Sweden)

    Liskova J

    2015-01-01

    Full Text Available Jana Liskova,1 Oleg Babchenko,2 Marian Varga,2 Alexander Kromka,2 Daniel Hadraba,1 Zdenek Svindrych,1 Zuzana Burdikova,1 Lucie Bacakova1 1Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic; 2Institute of Physics, Academy of Sciences of the Czech Republic, Prague, Czech Republic Abstract: Nanocrystalline diamond (NCD films are promising materials for bone implant coatings because of their biocompatibility, chemical resistance, and mechanical hardness. Moreover, NCD wettability can be tailored by grafting specific atoms. The NCD films used in this study were grown on silicon substrates by microwave plasma-enhanced chemical vapor deposition and grafted by hydrogen atoms (H-termination or oxygen atoms (O-termination. Human osteoblast-like Saos-2 cells were used for biological studies on H-terminated and O-terminated NCD films. The adhesion, growth, and subsequent differentiation of the osteoblasts on NCD films were examined, and the extracellular matrix production and composition were quantified. The osteoblasts that had been cultivated on the O-terminated NCD films exhibited a higher growth rate than those grown on the H-terminated NCD films. The mature collagen fibers were detected in Saos-2 cells on both the H-terminated and O-terminated NCD films; however, the quantity of total collagen in the extracellular matrix was higher on the O-terminated NCD films, as were the amounts of calcium deposition and alkaline phosphatase activity. Nevertheless, the expression of genes for osteogenic markers – type I collagen, alkaline phosphatase, and osteocalcin – was either comparable on the H-terminated and O-terminated films or even lower on the O-terminated films. In conclusion, the higher wettability of the O-terminated NCD films is promising for adhesion and growth of osteoblasts. In addition, the O-terminated surface also seems to support the deposition of extracellular matrix proteins and extracellular matrix

  6. The relationship of C-reactive protein levels and positive culture with quality of life in acute rhinosinusitis

    Directory of Open Access Journals (Sweden)

    Schalek P

    2015-01-01

    Full Text Available Petr Schalek, Zuzana Hornáčková, Aleš Hahn Ear, Nose and Throat department, 3rd Medical Faculty of Charles University, Prague, Czech Republic Background: Acute rhinosinusitis (ARS has been shown to significantly reduce patient quality of life (QoL. While the QoL in patients with chronic rhinosinusitis has been the subject of intensive research over the last decade, studies measuring the impact of ARS on patient QoL have remained relatively scarce. The aim of this study was to determine the relationship between the QoL and parameters suggestive of acute bacterial rhinosinusitis (C-reactive protein [CRP] levels and positive culture and to see if measurement of the QoL could be used as an indicator for antibiotic treatment in ARS.Methods: Eighty patients with ARS were enrolled in the study. A novel QoL instrument for patients with ARS, called Measurement of Acute Rhinosinusitis (MARS questionnaire, was given to patients at the time of diagnosis. We assessed patient QoL, obtained endoscopically guided cultures from the middle meatus, and measured levels of CRP. The relationship between QoL MARS scores (QoL-Mscores and CRP was determined using a correlation coefficient. To compare QoL-Mscores, relative to culture-positive and culture-negative patients, the Student’s t-test was used.Results: No correlation between the QoL, assessed using the MARS questionnaire, and positive middle meatus culture was demonstrated (P=0.332. A weak correlation was found between QoL-Mscores and CRP values, with a correlation coefficient of 0.221 and P=0.0498.Conclusion: No correlation between the QoL in ARS patients and positive culture was found in this study. The clinical significance of the correlation between QoL-Mscores and CRP values in the antibiotic decision making process needs further research. Keywords: endoscopy, quality of life, questionnaires, anti-bacterial agents

  7. Quality of life in borderline patients comorbid with anxiety spectrum disorders – a cross-sectional study

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    Grambal A

    2016-08-01

    Full Text Available Ales Grambal,1 Jan Prasko,1 Dana Kamaradova,1 Klara Latalova,1 Michaela Holubova,1,2 Zuzana Sedláčková,3 Radovan Hruby4 1Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital, Olomouc, 2Department of Psychiatry, Hospital Liberec, Liberec, 3Department of Psychology, Faculty of Arts, Palacky University Olomouc, Olomouc, Czech Republic; 4Private Practice, Martin, Slovak Republic Introduction: Borderline personality disorder (BPD significantly reduces the quality of life (QoL in mental, social, and work domains. Patients with BPD often suffer from depressive anxiety symptoms. The purpose of this cross-sectional study was to compare the QoL and demographic and clinical factors of inpatients diagnosed with BPD and comorbid anxiety spectrum disorders, and healthy controls.Methods: Ninety-two hospitalized patients treated in the psychotherapeutic department and 40 healthy controls were included. Subjects were assessed by the Quality of Life Satisfaction and Enjoyment Questionnaire (Q-LES-Q, Dissociative Experiences Scale, Beck Depression Inventory (BDI-II, Beck Anxiety Inventory, Clinical Global Impression, demographic questionnaire, Sheehan Disability Scale (SDS, and Sheehan Anxiety Scale.Results: BPD patients suffered from comorbid anxiety disorders, panic disorder (18.5%, social phobia (20.7%, generalized anxiety disorder/mixed anxiety depression disorder (17.4%, adjustment disorder (22.8%, and posttraumatic stress disorder (8.7%; 19.6% patients had two or more anxiety disorder comorbidities. Patients score in Q-LES-Q (general was 36.24±9.21, which was significantly lower in comparison to controls (57.83±10.21 and similar in all domains (physical health, feelings, work, household, school/study, leisure, social activities. The subjective level of depression measured by BDI and SDS (social life and family subscales negatively correlated with all Q-LES-Q domains.Conclusion: Patients suffering

  8. Personality features, dissociation, self-stigma, hope, and the complex treatment of depressive disorder

    Directory of Open Access Journals (Sweden)

    Prasko J

    2016-10-01

    Full Text Available Jan Prasko,1 Marie Ociskova,1 Ales Grambal,1 Zuzana Sigmundova,1 Petra Kasalova,1 Marketa Marackova,1 Michaela Holubova,1,2 Kristyna Vrbova,1 Klara Latalova,1 Milos Slepecky3 1Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, 2Department of Psychiatry, Hospital Liberec, Liberec, Czech Republic; 3Department of Psychology Sciences, Faculty of Social Science and Health Care, Constantine the Philosopher University in Nitra, Nitra, Slovak Republic Objective: Identifying the predictors of response to psychiatric and psychotherapeutic treatments may be useful for increasing treatment efficacy in pharmacoresistant depressive patients. The goal of this study was to examine the influence of dissociation, hope, personality trait, and selected demographic factors in treatment response of this group of patients.Methods: Pharmacoresistant depressive inpatients were enrolled in the study. All patients completed Clinical Global Impression – both objective and subjective form (CGI, Beck Depression Inventory (BDI, and Beck Anxiety Inventory (BAI at baseline and after 6 weeks of combined pharmacotherapy and psychotherapy (group cognitive-behavioral or group psychodynamic treatment as an outcome measures. The Internalized Stigma of Mental Illness Scale (ISMI, Dissociative Experience Scale (DES, Adult Dispositional Hope Scale (ADHS, and Temperament and Character Inventory (TCI-R were completed at the start of the treatment with the intention to find the predictors of treatment efficacy.Results: The study included 72 patients who were hospitalized for the pharmacoresistant major depression; 63 of them completed the study. The mean scores of BDI-II, BAI, subjCGI, and objCGI significantly decreased during the treatment. BDI-II relative change statistically significantly correlated with the total ISMI score, Discrimination Experience (ISMI subscale, and Harm Avoidance (TCI-R personality trait

  9. Major results of the MAARBLE project

    Science.gov (United States)

    Daglis, Ioannis A.; Bourdarie, Sebastien; Horne, Richard B.; Khotyaintsev, Yuri; Mann, Ian R.; Santolik, Ondrej; Turner, Drew L.; Balasis, Georgios

    2016-04-01

    Anastasiadis, Vassilis Angelopoulos, David Barona, Eleni Chatzichristou, Stavros Dimitrakoudis, Marina Georgiou, Omiros Giannakis, Sarah Glauert, Benjamin Grison, Zuzana Hrbackova, Andy Kale, Christos Katsavrias, Tobias Kersten, Ivana Kolmasova, Didier Lazaro, Eva Macusova, Vincent Maget, Meghan Mella, Nigel Meredith, Fiori-Anastasia Metallinou, David Milling, Louis Ozeke, Constantinos Papadimitriou, George Ropokis, Ingmar Sandberg, Maria Usanova, Iannis Dandouras, David Sibeck, Eftyhia Zesta.

  10. POPE study: rationale and methodology of a study to phenotype patients with COPD in Central and Eastern Europe

    Directory of Open Access Journals (Sweden)

    Zbozinkova Z

    2016-03-01

    Full Text Available Zuzana Zbozinkova,1 Adam Barczyk,2 Ruzena Tkacova,3 Arschang Valipour,4 Neven Tudoric,5 Kirill Zykov,6 Attila Somfay,7 Marc Miravitlles,8 Vladimir Koblizek91Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic; 2Department of Pneumology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland; 3Department of Respiratory Medicine, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; 4Department of Respiratory and Critical Care Medicine, Ludwig-Boltzmann-Institute for COPD and Respiratory Epidemiology, Otto-Wagner-Spital, Wien, Austria; 5School of Medicine Zagreb, University Hospital Dubrava, Zagreb, Croatia; 6Laboratory of Pulmonology, Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia; 7Department of Pulmonology, University of Szeged, Deszk, Hungary; 8Pneumology Department, Hospital Universitari Vall d’Hebron, CIBER de Enfermedades Respiratorias (CIBERES, Barcelona, Spain; 9Department of Pneumology, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech RepublicIntroduction: Chronic obstructive pulmonary disease (COPD constitutes a major health challenge in Central and Eastern European (CEE countries. However, clinical phenotypes, symptom load, and treatment habits of patients with COPD in CEE countries remain largely unknown. This paper provides a rationale for phenotyping COPD and describes the methodology of a large study in CEE.Methods/design: The POPE study is an international, multicenter, observational cross-sectional survey of patients with COPD in CEE. Participation in the study is offered to all consecutive outpatients with stable COPD in 84 centers across the CEE region if they fulfill the following criteria: age >40 years, smoking history ≥10 pack-years, a confirmed diagnosis of COPD with postbronchodilator FEV1/FVC ,0.7, and absence

  11. Prediction of antigenic epitopes on HA, NA amino acid sequences of novel influenza A (H7N9) virus and analysis association between susceptibility and HLA-Ⅱalleles%H7 N9流感病毒HA、NA蛋白的抗原表位预测及其与HLA-Ⅱ类等位基因的相关性分析

    Institute of Scientific and Technical Information of China (English)

    刘雪婷; 王珊; 张俊艳; 刘兆宇; 陈惠芳; 邹泽红; 肖兰艳; 及志恒; 何颖

    2015-01-01

    Objective:To compare the amino acid sequences difference of HA,NA novel influenza virus A/H7N9 isolates, decipher possible B cell epitopes and T cell epitopes of HA,NA protein,and analyze the association between susceptibility and HLA polymorphisms.Methods:The amino acid sequences of novel influenza A ( H7N9) virus were downloaded from Genbank.Phylogenetic trees were constructed based on the amino acid sequences of HA and NA by using software Clustal X and MEGA 4.0.B cell and T cell epitopes were respectively predicted with Protean software and NetMHCⅡ2.2 Server online server.Results:The homology of HA and NA proteins of H7N9 virus was high.10 B cell epitopes and 15 T cell epitopes were randomly distributed throughout HA sequence and 12 B cell epitopes and 9 T cell epitopes were randomly distributed throughout NA sequence.HLA-DRB1*0701 allele which was commonly observed in Northern Chinese population have a high binding affinity for 9-mer peptides of HA and NA proteins.Conclusion:The prediction of B and T cell epitopes of HA and NA proteins with multiple methods benefits the research and development of vaccine against human infection with avian influenza A H7N9 virus.HLA-DRB1*0701 allele may contribute to susceptibility to novel influenza A (H7N9) virus.H7N9 influenza virus is more easily spread in Urumqi,Harbin,Shandong Province,Liaoning Province,Beijing, Shijiazhuang and Tianjin of China.%目的:分析H7N9流感病毒的HA、NA蛋白的抗原表位;预测H7N9流感病毒相关的HLA-Ⅱ类等位基因及易感人群。方法:软件分析HA、NA的同源性、B细胞表位、T细胞表位以及与HA、NA结合力强的HLA-Ⅱ类等位基因;并根据该等位基因在亚洲不同地域的基因频率,预测H7N9的易感人群。结果:H7N9流感病毒株之间氨基酸序列相对保守;HA具有10个B细胞表位和15个T细胞表位;NA有12个B细胞表位和9个T细胞表位;HLA等位基因DRB1*0701与HA、NA具有强结合力,在新

  12. Agua, arquitectura y poder en una capital del Islam: la finca real del Agdal de Marrakech (ss. XII-XX

    Directory of Open Access Journals (Sweden)

    Navarro Palazón, Julio

    2013-12-01

    Full Text Available The Agdal is a royal country estate located to the South of Marrakech and annexed to the kasba, founded in the Almohad period. The current enclosure is an area of 340 ha and consists mainly of orchards farmed uninterruptedly for centuries. Over 40 preserved buildings and numerous archaeological remains have been catalogued in its interior. Among these remains, the enclosure of the Dar al-Hana has been identified with the residential area of the Almohad and Saadian periods. In the southern area of this complex, the remains of a large central court Saadian palace, built on a previous Almohad one, have been identified. The enlargement of the Agdal northwards, which converted an isolated country estate (an almunia into an appendix of the kasba, has been also recorded. The archeological prospection of the Tasltante plain, close to the Agdal, has allowed defining a model of country state and a settlement pattern, which is also followed by this royal property. The archaeological information and the analysis of the written sources have made possible to reconstruct the Agdal and the peri-urban landscape previous to the Alaouite restoration of the imperial capital status to Marrakech in the eighteenth century.El Agdal es una finca real situada al sur de Marrakech y anexa a la kasba, fundada en época almohade. El perímetro amurallado actual contiene 340 ha que en su mayor parte son huertas que se han mantenido cultivadas ininterrumpidamente. En su interior se han estudiado más de 40 edificios conservados y numerosos restos arqueológicos; los más significativos han permitido identificar el recinto de Dar al-Hana como el área residencial de la finca almohade y saadí. Al sur de este recinto se han localizado los restos de un gran palacio saadí de patio central, edificado sobre otro más antiguo de época almohade. La prospección arqueológica origen de la presente investigación ha documentado el proceso de expansión del Agdal hacia el norte, que

  13. A point mutation in the polymerase protein PB2 allows a reassortant H9N2 influenza isolate of wild-bird origin to replicate in human cells.

    Science.gov (United States)

    Hussein, Islam T.M.; Ma, Eric J.; Meixell, Brandt; Hill, Nichola J.; Lindberg, Mark S.; Albrecht , Randy A.; Bahl, Justin; Runstadler, Jonathan A.

    2016-01-01

    H9N2 influenza A viruses are on the list of potentially pandemic subtypes. Therefore, it is important to understand how genomic reassortment and genetic polymorphisms affect phenotypes of H9N2 viruses circulating in the wild bird reservoir. A comparative genetic analysis of North American H9N2 isolates of wild bird origin identified a naturally occurring reassortant virus containing gene segments derived from both North American and Eurasian lineage ancestors. The PB2 segment of this virus encodes 10 amino acid changes that distinguish it from other H9 strains circulating in North America. G590S, one of the 10 amino acid substitutions observed, was present in ~ 12% of H9 viruses worldwide. This mutation combined with R591 has been reported as a marker of pathogenicity for human pandemic 2009 H1N1 viruses. Screening by polymerase reporter assay of all the natural polymorphisms at these two positions identified G590/K591 and S590/K591 as the most active, with the highest polymerase activity recorded for the SK polymorphism. Rescued viruses containing these two polymorphic combinations replicated more efficiently in MDCK cells and they were the only ones tested that were capable of establishing productive infection in NHBE cells. A global analysis of all PB2 sequences identified the K591 signature in six viral HA/NA subtypes isolated from several hosts in seven geographic locations. Interestingly, introducing the K591 mutation into the PB2 of a human-adapted H3N2 virus did not affect its polymerase activity. Our findings demonstrate that a single point mutation in the PB2 of a low pathogenic H9N2 isolate could have a significant effect on viral phenotype and increase its propensity to infect mammals. However, this effect is not universal, warranting caution in interpreting point mutations without considering protein sequence context.

  14. 《美容整形外科》(Aesthetic Plastic Surgery)2001年第25卷第4期目录

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Aesthetic Plastic Surgery Volume 25 , Number 4, 2001 249 The Value of a New Filler Material in Corrective and Cosmetic Surgery: DermaLive and DermaDeep Catherine Bergeret-Galley , Xavier Latouche , Yves-Gérard Illouz 256 Fat Transplantation for Soft Tissue Augmentation in the Lower Limbs M. Stampos, P. Xepoulias 262 The Effect of Reduction of the Peripheral Fat Content by Liposuction-Assisted Lipectomy (SAL) on Serum Leptin Levels in the Postoperative Period: A Prospective Study Ran Talisman, Nik Belinson, Dalit Modan-Moses, Hana Canti, Arie Orenstein, Zohar,Barzilai, Gideon Parret 266 Short Columella Nasolabial Complex in Aesthetic Rhinoplasty A. Aldo Mottura 273 Nasal Reconstruction After Epithelioma Salvador Rodriguez-Camps 278 PVP Breast Implants After Two Years: Initial Results of a Prospective Study Henrik Menke , H. GrUbmeyer, E. Biemer, R. R. Olbrisch 283 Mammographic Findings Following Reduction Mammoplasty Dimitrios Danikas, Spero J. V. Theodorou, George Kokkalis, Katerina Vasiou, Konstantina K yriakopoulou 286 Unsatisfactory Results of Periareolar Mastopexy With or Without Augmentation and Reduction Mammoplasty: Enlarged Areola With Flattened Nipple Cihat N. Baran, Fatih Peker , Turgut Ortak , Omer Sensoz , Namik K. Baran 290 Postoperative Compression After Breast Augmentation Bassem Nathan, Shiva Singh 292 Breast Augmentation with Fresh-Frozen Homologous Fat Grafts J. Haik, R. Talisman, J. Tamir, J. Frand, E. Gazit, J. Schibi, A. Glicksman, A. Orenstein 295 Upper Eyelid Mycobacterial Infection Following Oriental Blepharoplasty in a Pulmonary Tuberculosis Patient Samuel H. T. Chen, Chun-Hua Wang, Hung-Chi Chen, George C. J. Weng, Paul-Yann Lin, Fu-Chan Wei 299 Clinical Facial Photography in a Small Office:Lighting Equipment and Technique Fabio Meneghini 307 Specific Requirements for Preoperative and Postoperative Photos Used in Publication Irene Talamas and Luis Pando 311 Announcements

  15. The Big Data Tools Impact on Development of Simulation-Concerned Academic Disciplines

    Directory of Open Access Journals (Sweden)

    A. A. Sukhobokov

    2015-01-01

    Full Text Available The article gives a definition of Big Data on the basis of 5V (Volume, Variety, Velocity, Veracity, Value as well as shows examples of tasks that require using Big Data tools in a diversity of areas, namely: health, education, financial services, industry, agriculture, logistics, retail, information technology, telecommunications and others. An overview of Big Data tools is delivered, including open source products, IBM Bluemix and SAP HANA platforms. Examples of architecture of corporate data processing and management systems using Big Data tools are shown for big Internet companies and for enterprises in traditional industries. Within the overview, a classification of Big Data tools is proposed that fills gaps of previously developed similar classifications. The new classification contains 19 classes and allows embracing several hundreds of existing and emerging products.The uprise and use of Big Data tools, in addition to solving practical problems, affects the development of scientific disciplines concerning the simulation of technical, natural or socioeconomic systems and the solution of practical problems based on developed models. New schools arise in these disciplines. These new schools decide peculiar to each discipline tasks, but for systems with a much bigger number of internal elements and connections between them. Characteristics of the problems to be solved under new schools, not always meet the criteria for Big Data. It is suggested to identify the Big Data as a part of the theory of sorting and searching algorithms. In other disciplines the new schools are called by analogy with Big Data: Big Calculation in numerical methods, Big Simulation in imitational modeling, Big Management in the management of socio-economic systems, Big Optimal Control in the optimal control theory. The paper shows examples of tasks and methods to be developed within new schools. The educed tendency is not limited to the considered disciplines: there are

  16. CD4/CD8 ratio is not predictive of multi-morbidity prevalence in HIV-infected patients but identify patients with higher CVD risk

    Directory of Open Access Journals (Sweden)

    Marianna Menozzi

    2014-11-01

    Full Text Available Background: CD4/CD8=2006. High CVD risk was defined for Framingham Risk Score (FRS≥6. Subclinical CVD was defined using cardiac CT scan for calcium score (CAC≥100. Logistic univariate and multivariable adjusted analysis were performed to assess relationships between variables. Results: Demographic and HIV-specific variables distribution in patients with and without MM are shown in Table 1. Figure 1 shows HANA distribution across CD4/CD8 strata: CVD prevalence only appeared to be higher in patients with no CD4/CD8>0.8.In multivariable analyses CD4/CD8<0.8 was not an independent predictor of MM (OR=1.225, CI 0.891; 1.681, p=0.211 after adjustment for age, gender and BMI. Patients with CD4/CD8<0.8 displayed higher CVD risk but not higher prevalence of subclinical CVD. At multivariable analyses CD4/CD8<0.8 remained predictor of higher CVD risk (OR=0.65, CI 0.47–0.917, p=0.014 after correction for sex, BMI, age strata and HIV infection duration. Conclusions: Low CD4/CD8 ratio was not associated with MM prevalence. Patients with CD4/CD8<0.8 ratio displayed higher prevalence of CVD. At multivariable logistic regression CD4/CD8<0.8 is an independent prepredictor of enhanced CVD risk. This may support role of immune-activation/senescence in the pathogenesis of CVD.

  17. Irradiation Test in HANARO of the Parts of an X-Gen Nuclear Fuel Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Choo, K. N.; Kim, B. G.; Kang, Y. H. (and others)

    2008-08-15

    An instrumented capsule of 07M-13N was designed, fabricated and irradiated for an evaluation of the neutron irradiation properties of the parts of an X-Gen nuclear fuel assembly for PWR requested by KNF. Some specimens requested by Westinghouse Co. and Hanyang university were also inserted. 389 KNF specimens such as bucking and spring test specimens of 1x1 cell spacer grid, tensile, microstructure and tensile of welded parts, irradiation growth, spring test specimens made of HANA tube, Zirlo, Zircaloy-4, Inconel-718 were placed in the capsule. The capsule was composed of 5 stages having many kinds of specimens and an independent electric heater at each stage. During the irradiation test, the temperature of the specimens and the thermal/fast neutron fluences were measured by 14 thermocouples and 7 sets of Ni-Ti-Fe (2 sets contain additional Nb-Ag) neutron fluence monitors installed in the capsule. The capsule was irradiated for 59.19days (4 cycles) in the CT test hole of HANARO of a 30MW thermal output at 300 {approx} 420 .deg. C(for KNF specimens) up to a fast neutron fluence of 1.27x10{sup 21}(n/cm{sup 2}) (E>1MeV). After an irradiation test, the main body of the capsule was cut off at the bottom of the protection tube with a cutting system and it was transported to the IMEF (Irradiated Materials Examination Facility). The irradiated specimens were tested to evaluate the irradiation performance of the parts of an X-Gen fuel assembly in the IMEF hot cell.

  18. Wavelength Selection For Laser Raman Spectroscopy of Putative Martian Habitats and Biomolecules

    Science.gov (United States)

    Wynn-Williams, D. D.; Newton, E. M. G.; Edwards, H. G. M.

    Pigments are key potential biomarkers for any former life on Mars because of the selective pressure of solar radiation on any biological system that could have evolved at its surface. We have found that the near -Infrared laser Raman spectrometer available to use was eminently suitable for diagnostic analysis of pigments because of their minimal autofluorescence at its 1064 nm excitation wav elength. However, we have now evaluated a diverse range of excitation wavelengths to confirm this choice, to ensure that we have the best technique to seek for pigments and their derivatives from any former surface life on Mars. The Raman is weak relative to fluorescence, which results in elevated baseline and concurrent swamping of Raman bands. We confirm the molecular information available from near-IR FT Raman spectra for two highly pigmented UV-tolerant epilithic Antarctic lichens (Acarospora chlorop hana and Caloplaca saxicola) from Victoria Land, a whole endolithic microbial community and endolithic cyanobacterium Chroococcidiopsis from within translucent sandstone of the Trans -Antarctic Mountains, and the free- living cyanobacterium Nostoc commune from Alexander Island, Antarctic Peninsula region. We also show that much of the information we require on biomolecules is not evident from lasers of shorter wavelengths. A miniature 1064 nm Raman spectrometer with an In-Ga-As detector sensitive to IR is being developed by Montana State University (now existing as a prototype) as the prime instrument for a proposed UK-led Mars rover mission (Vanguard). Preliminary spectra from this system confirm the suitability of the near-IR laser.

  19. Dissociative symptoms reflect levels of tumor necrosis factor alpha in patients with unipolar depression

    Directory of Open Access Journals (Sweden)

    Bizik G

    2014-04-01

    Full Text Available Gustav Bizik,1 Petr Bob,1 Jiri Raboch,1 Josef Pavlat,1 Jana Uhrova,2 Hana Benakova,2 Tomas Zima2 1Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry and UHSL, 2Department of Clinical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic Abstract: Recent evidence indicates that the nature of interactions between the nervous system and immune system is important in the pathogenesis of depression. Specifically, alterations in pro-inflammatory cytokines have been related to the development of several psychological and neurobiological manifestations of depressive disorder, as well as to stress exposure. A number of findings point to tumor necrosis factor alpha (TNF-α as one of the central factors in these processes. Accordingly, in the present study, we test the hypothesis that specific influences of chronic stressors related to traumatic stress and dissociation are related to alterations in TNF-α levels. We performed psychometric measurement of depression (Beck Depression Inventory [BDI]-II, traumatic stress symptoms (Trauma Symptom Checklist [TSC]-40, and psychological and somatoform dissociation (Dissociative Experiences Scale [DES] and Somatoform Dissociation Questionnaire [SDQ]-20, respectively, and immunochemical measure of serum TNF-α in 66 inpatients with unipolar depression (mean age 43.1 ± 7.3 years. The results show that TNF-α is significantly related to DES (Spearman R=−0.42, P<0.01, SDQ-20 (Spearman R=−0.38, P<0.01, and TSC-40 (Spearman R=−0.41, P<0.01, but not to BDI-II. Results of the present study suggest that TNF-α levels are related to dissociative symptoms and stress exposure in depressed patients. Keywords: depression, dissociation, TNF-alpha, traumatic stress

  20. Distorsi citra tubuh, perilaku makan, dan fad diets pada remaja putri di Yogyakarta

    Directory of Open Access Journals (Sweden)

    Atika Sulistyan

    2016-01-01

    Full Text Available Background: Vast changing environment and culture including mass media which commonly shows models with a very slim body may cause teenage girls feel fatty and not confident despite their normal body weight. This misperception may influence eating behavior and encourage them to lose weight by involving in some instant diets, for example, fad diets. Objective: To identify relationships between body image distortion, eating behavior, and fad diets among female adolescents in Yogyakarta. Method: This study was a cross-sectional study on 123 school girls at SMAN 8 Yogyakarta who have normal body mass index (BMI according to WHO category. Body image distortion and eating behavior were evaluated using the Body Image Assesment-Body Dimension (BIAS-BD, and the Eating Attitude Test (EAT-26, respectively. Fad diets were assessed using a questionnaire adapted from Hana (10 and Rafiqa (11. The hypotheses were tested using chi-square test and Spearman’s correlations. Results: As many as 105 girls (85.4% showed body image distortion and 15 girls (12.2% were at risks for having disordered eating behavior. Among 51 girls (42.5% who experienced or tried to lose weight, 47 girls (92.2% were practicing fad diets. There was no significant association between body image distortion and disordered eating behavior, nor between body image distortion and fad diets. However, disordered eating behavior was significantly associated with fad diets with OR = 7,077 (p<0.05. Conclusion: There was a significant relationship (p<0.05 between disordered eating behavior and fad diets, however, no significant association was found between body image distortion and disordered eating behavior, and between body image distortion and fad diets among female adolescents in Yogyakarta.

  1. Mutation breedings in ornamental plants. Technique used for radiation induced mutant in begonia, chrysanthemum, aberia and winter daphne

    Energy Technology Data Exchange (ETDEWEB)

    Matsubara, Hisao

    1984-03-01

    Several methods of obtaining somatic mutant plants by el-ray irradiation on pieces of tissues as in vitro adventitious bud technique or small cutting methods with repeated pruning are described. The irradiation to the adventitious buds in the small pieces of organ cultured in vitro and to the small cuttings are employed. Culture beds of agar or of Japanese Kanuma soil were used in vitro culture. In these experiments, Japanese Kanuma soil bed in in vitro culture worked well for root development and transplant of the induced mutants. Combination with in vitro culture and repeated pruning technique were used for isolation and fixation of solid somatic mutant from small sectorial mutation induced by irradiation. This method was successful for begonia, chrysanthemum, aberia and winter daphne. These data indicates that most of the induced mutant plants were non-chimeric, while a few others were chimeric. Among the new varieties, ''Gin-Sei'', ''Ryoku-Ha'', ''Big-Cross'', ''Kaede-Iron'', ''Mei-Fu-Hana-Tsukubane-Utsugi'' and ''Daphne-el-3'' are non-chimeric, and ''Mini-Mini-Iron'' and ''Orange-Iron'' are chimeric. Moreover, these new varieties have remarkably differed in size and in color pattern from original variety. From the experimental results of somatic mutation, it is indicated that plant tissue culture have enormous potential in radiation breeding and in rapid propagation of the somatic mutant. (author).

  2. Final Report on Design, Fabrication and Test of HANARO Instrumented Capsule (07M-13N) for the Researches of Irradiation Performance of Parts of X-Gen Nuclear Fuel Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Choo, K. N.; Kim, B. G.; Kang, Y. H. (and others)

    2008-08-15

    An instrumented capsule of 07M-13N was designed, fabricated and irradiated for an evaluation of the neutron irradiation properties of the parts of a X-Gen nuclear fuel assembly for PWR requested by KNF. Some specimens of control rod materials of AP1000 reactor requested by Westinghouse Co. were inserted in this capsule as a preliminary irradiation test and Polyimide specimens requested by Hanyang university were also inserted. 463 specimens such as buckling and spring test specimens of cell spacer grid, tensile, microstructure and tensile of welded parts, irradiation growth, spring test specimens made of HANA tube, Zirlo, Zircaloy-4, Inconel-718, Polyimide, Ag and Ag-In-Cd alloys were placed in the capsule. During the irradiation test, the temperature of the specimens and the thermal/fast neutron fluences were measured by 14 thermocouples and 7 sets of neutron fluence monitors installed in the capsule. A new friction welded tube between STS304 and Al1050 alloys was introduced in the capsule to prevent a coolant leakage into a capsule during a capsule cutting process in HANARO. The capsule was irradiated for 95.19 days (4 cycles) in the CT test hole of HANARO of a 30MW thermal output at 230 {approx} 420 .deg. C. The specimens were irradiated up to a maximum fast neutron fluence of 1.27x10{sup 21}(n/cm{sup 2}) (E>1.0MeV) and the dpa of the irradiated specimens were evaluated as 1.21 {approx} 1.97. The irradiated specimens were tested to evaluate the irradiation performance of the parts of an X-Gen fuel assembly in the IMEF hot cell and the obtained results will be very valuable for the related researches of the users.

  3. SCHOOL COMMUNITY PERCEPTION OF LIBRARY APPS AGAINTS LIBRARY EMPOWERMENT

    Directory of Open Access Journals (Sweden)

    Achmad Riyadi Alberto

    2017-07-01

    Full Text Available Abstract. This research is motivated by the development of information and communication technology (ICT in the library world so rapidly that allows libraries in the present to develop its services into digital-based services. This study aims to find out the school community’s perception of library apps developed by Riche Cynthia Johan, Hana Silvana, and Holin Sulistyo and its influence on library empowerment at the library of SD Laboratorium Percontohan UPI Bandung. Library apps in this research belong to the context of m-libraries, which is a library that meets the needs of its users by using mobile platforms such as smartphones,computers, and other mobile devices. Empowerment of library is the utilization of all aspects of the implementation of libraries to the best in order to achieve the expected goals. An analysis of the schoolcommunity’s perception of library apps using the Technology Acceptance Model (TAM includes: ease of use, usefulness, usability, usage trends, and real-use conditions. While the empowerment of the library includes aspects: information empowerment, empowerment of learning resources, empowerment of human resources, empowerment of library facilities, and library promotion. The research method used in this research is descriptive method with quantitative approach. Population and sample in this research is school community at SD Laboratorium Percontohan UPI Bandung. Determination of sample criteria by using disproportionate stratified random sampling with the number of samples of 83 respondents. Data analysis using simple linear regression to measure the influence of school community perception about library apps to library empowerment. The result of data analysis shows that there is influence between school community perception about library apps to library empowerment at library of SD Laboratorium Percontohan UPI Bandung which is proved by library acceptance level and library empowerment improvement.

  4. Primary Whipple disease of the brain: case report with long-term clinical and MRI follow-up

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    Peregrin J

    2015-09-01

    Full Text Available Jan Peregrin,1 Hana Malikova2,3 1Department of Neurology, 2Department of Radiology, Na Homolce Hospital, 3Second Faculty of Medicine, Institute of Anatomy, Charles University, Prague, Czech Republic Abstract: Whipple disease (WD is a rare systemic disorder caused by the bacteria Tropheryma whipplei. In its classic form, it manifests with gastrointestinal problems including diarrhea, abdominal pain, and weight loss. However, various other systems can be affected, including the central nervous system (CNS. Even more rarely, the CNS is primarily affected without gastrointestinal symptoms and with a negative small bowel biopsy. The incidence of primary CNS WD is unknown. We report the case of a young female with the primary CNS form of WD. In this report, we highlight the main clinical features and diagnostic procedures that lead to the diagnosis and comment on the treatment and clinical response. We stress the importance of neuroimaging and brain biopsy. A unique feature of this case is that the patient has been followed up for 12 years. At the time of diagnosis, no neurological manifestations were detected, although a tumor-like lesion in the right temporal lobe and hypothalamic infiltration were present on magnetic resonance imaging (MRI. The first neurological manifestations developed 2 years later despite recommended antibiotic treatment, with cognitive impairment developing more than 10 years later. According to the MRI findings and clinical course, the disease was active for several years when multiple lesions on MRI appeared despite antibiotic therapy. In the discussion, we compare the present case with similar cases previously reported and we elaborate on the similarities and discrepancies in clinical features, diagnostic procedures, results, and treatment options. Keywords: central nervous system, brain biopsy, antibiotic treatment

  5. Attention deficit hyperactivity disorder and disordered eating behaviors: links, risks, and challenges faced

    Directory of Open Access Journals (Sweden)

    Ptacek R

    2016-03-01

    Full Text Available Radek Ptacek,1,2 George B Stefano,1,3 Simon Weissenberger,1 Devang Akotia,1 Jiri Raboch,1 Hana Papezova,1 Lucie Domkarova,1 Tereza Stepankova,1 Michal Goetz4 1Department of Psychiatry, Charles University 1st Medical Faculty and General Teaching Hospital, Prague, Czech Republic; 2Department of Psychology, University of New York in Prague, Prague, Czech Republic; 3MitoGenetics Research Institute, MitoGenetics, LLC, Farmingdale, NY, USA; 4Department of Child Psychiatry, Charles University Second Faculty of Medicine, University Hospital Motol, Prague, Czech Republic Abstract: Attention deficit hyperactivity disorder (ADHD is a neurodevelopmental disorder that often persists in adulthood. It is defined by inattention and/or hyperactivity–impulsivity. ADHD is associated with many comorbidities, including eating disorders (EDs. In the last decade, studies have reported that ADHD is linked with binge EDs, bulimia nervosa, and anorexia nervosa. Many postulates have been proposed to explain the association: 1 impulsive behavior in ADHD patients leads to disordered eating behavior; 2 other psychologic comorbidities present in ADHD patients account for eating behavior; 3 poor eating habits and resulting nutritional deficiencies contribute to ADHD symptoms; and 4 other risk factors common to both ADHD and EDs contribute to the coincidence of both diseases. Additionally, sex differences become a significant issue in the discussion of EDs and ADHD because of the higher incidence of bulimia nervosa and anorexia nervosa in females and the ability of females to mask the symptoms of ADHD. Interestingly, both EDs and ADHD rely on a common neural substrate, namely, dopaminergic signaling. Dopaminergic signaling is critical for motor activity and emotion, the latter enabling the former into a combined motivated movement like eating. This linkage aids in explaining the many comorbidities associated with ADHD. The interconnection of ADHD and EDs is discussed from

  6. PENGARUH CADANGAN WAJIB MINIMUM DAN TINGKAT SUKU BUNGA TERHADAP INFLASI DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Yesi Aprianti Sir

    2015-12-01

    Full Text Available The study aimed to measure the impact of monetery policy issued by Bank of Indonesia (BI, that has the authority, on the inflation happening in Indonesia. Empirical variables included minimum mandatory reservesin minimum mandatory giro (X1 and interest rate of BI (X2 towards the inflation development (Y in Indonesia. The research used quarterly data in 1993-2009. Monetery policyis intended to increase the amount of Statutory and BI rate and to lower the inflation. This means tha tthe inflation and monetary policy had negative relationship. Simple Regression with double log was employed to analyze the data. The research confirmed that there was apositive effect between inflation and monetary policy. The statutory reserves and interest rates had a positive and significant impact on inflation in Indonesia in the short term. It means that the increase of compulsory reserves and BI rate will be accompanied bythe increase of inflation.Penelitian ini bertujuan untuk mengukur pengaruh kebijakan bank sentral sebagai otoritas moneter (Bank Indonesia atas penekanan inflasi di Indonesia. Variabel empiris uang digunakan dalam penelitian ini adalah cadangan wajib minimum yaitu giro wajib minimum (X1 dan tingkat suku bunga yaitu BI rate (X2 terhadap perkembangan inflasi (Y di Indonesia. Penelitian ini menggunakan data semesteran pada periode 1993-2009. Kebijakan moneter dilakukan dengan menaikan besaran Giro Wajib Minimum dan BI rate, dengan harapan akan menurunkan tingkat inflasi, artinya inflasi & kebijakan moneter memiliki hubungan negatif. Metode analisis yang digunakan dalam penelitian ini adalah analisis regresi seder­hana secara double log.Hasil penelitian menunjukan adanya pengaruh positif antara inflasi dan kebijak­an moneter. GWM dan tingkat suku bunga berpengaruh positif dan signifikan terhadap inflasi di Indonesia dalam jangka pendek. Artinya kenaikan cadangan wajib dan BI rate akan diiringi dengan kenaikan inflasi. 

  7. Impact of dissociation on treatment of depressive and anxiety spectrum disorders with and without personality disorders

    Directory of Open Access Journals (Sweden)

    Prasko J

    2016-10-01

    Full Text Available Jan Prasko,1 Ales Grambal,1 Petra Kasalova,1 Dana Kamardova,1 Marie Ociskova,1 Michaela Holubova,1,2 Kristyna Vrbova,1 Zuzana Sigmundova,1 Klara Latalova,1 Milos Slepecky,3 Marta Zatkova3 1Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University in Olomouc, University Hospital Olomouc, Olomouc, 2Psychiatric Department, Hospital Liberec, Liberec, Czech Republic; 3Department of Psychology Sciences, Faculty of Social Science and Health Care, Constantine the Philosopher University in Nitra, Nitra, Slovak Republic Objective: The central goal of the study was to analyze the impact of dissociation on the treatment effectiveness in patients with anxiety/neurotic spectrum and depressive disorders with or without comorbid personality disorders.Methods: The research sample consisted of inpatients who were hospitalized in the psychiatric department and met the ICD-10 criteria for diagnosis of depressive disorder, panic disorder, generalized anxiety disorder, mixed anxiety–depressive disorder, agoraphobia, social phobia, obsessive compulsive disorder, posttraumatic stress disorder, adjustment disorders, dissociative/conversion disorders, somatoform disorder, or other anxiety/neurotic spectrum disorder. The participants completed these measures at the start and end of the therapeutic program – Beck Depression Inventory, Beck Anxiety Inventory, a subjective version of Clinical Global Impression-Severity, Sheehan Patient-Related Anxiety Scale, and Dissociative Experience Scale.Results: A total of 840 patients with anxiety or depressive spectrum disorders, who were resistant to pharmacological treatment on an outpatient basis and were referred for hospitalization for the 6-week complex therapeutic program, were enrolled in this study. Of them, 606 were statistically analyzed. Data from the remaining 234 (27.86% patients were not used because of various reasons (103 prematurely finished the program, 131 did not fill in most of the

  8. Identifikace role produktového manažera a vytvoření standardní typové pozice Produktový manažer

    Directory of Open Access Journals (Sweden)

    Zuzana Wroblowská

    2013-10-01

    Full Text Available The purpose of the article: Is to clarify the profile role of a product manager in present entrepreneurial routine in the Czech Republic. It is said about the Product Manager that he is a product evangelist, responsible for managing full product lifecycles of their products, while ensuring accurate schedules, product features, and making sure that product benefits are communicated to business partners and customers. The author’s objective was to provide a look insight in to a realistic picture of product managers’ job as well as to describe the skills, education, experience and attributes required for the product management position. Methodology/methods: To deal with this issue the interdisciplinary approach was best to apply, because theoretical resources and current state analysis of the topic as well as tendencies in its development required research in several disciplines. For secondary data mainly descriptive or analysis/synthesis approach for examining available resources were used. For succeeding empiric research both qualitative content analysis and quantitative methodology were used. The author carried out a two-phase research project. Texts in 100 unique recruitment advertisements were studying in the first phase of the research. Data gathering was running by personal questioning in the Czech companies in the second phase of the project. Scientific aim: The article is based on the conclusions of the doctoral thesis of RNDr. Zuzana Wroblowská, Ph.D. The work was aimed at a human factor which intensifies or reduces the effectiveness of product oriented marketing, which is designated as product management. The purpose was to verify functionality and validity of the organizational frame of marketing, to analyze product management state in present entrepreneurial routine in the Czech Republic and to identify role profile of product and brand managers as well as support corporal routine with a type position standard. Findings: The

  9. Concentrations of selected heavy metals in bryophyte tissues at Cu-mine heap Podlipa in Ľubietová (Central Slovakia)

    Science.gov (United States)

    Širka, Pavel; Midula, Pavol

    2017-04-01

    absorption spectrometry with flame atomization (AVANTA Σ, GBC) was used. Concentrations of Fe in bryophyte samples were significantly higher compared to those in the soil and on average quite similar to those in vascular plants. Differences in contents of Cu were the most significant from all analyzed chemical elements. The highest concentrations of Cu in bryophyte samples were observed in both samples (9 and 10) of Pohlia drummondii (4010.3 mg.kg-1 and 1900.8 mg.kg-1 respectivelly), which in sample 9 was 18 to 470 times higher than in other bryophyte samples, slightly higher than the average value in the soil (3253 mg.kg-1) and considerably higher than in the leaves of Mentha longifolia (173.3 mg.kg-1), which had the highest concentration of Cu among vascular plants. Concentrations of Zn and Cd in bryophyte samples were on average slightly higher than in soil and vascular plant samples. On average, concentrations of Pb were considerably lower in bryophyte samples than in soil and vascular plant species. No significant differences were observed in Mn. Given their specific anatomy and morphology, there is a dispute in various studies as to whether a certain heavy metal is indeed the controlling factor for the distribution of bryophytes on metal-contaminated sites. Perhaps the tendency of these mosses to grow on mineralized substrates is a species characteristic, not a mutual one. Detailed study of bryophytes in relation to phytoextraction or phytostabilization of heavy metals may be used in succession management process aimed at restoring the environment, particularly the soil and air. Aknowledgement: This work was realised with the help of doc. RNDr. Zuzana Melichová, PhD. and Peter Harčár from the Department of Chemistry, Faculty of Natural Sciences, Matej Bel University in Banská Bystrica and financially supported by grant scheme VEGA 1/0538/15.

  10. Factors affecting health seeking behavior for common childhood illnesses in Yemen

    Directory of Open Access Journals (Sweden)

    Webair HH

    2013-10-01

    Full Text Available Hana Hasan Webair, Abdulla Salim Bin-Gouth Department of Family Medicine, Hadhramout University of Science and Technology, Almukalla, Hadhramout, Yemen Introduction: Appropriate medical care seeking could prevent a significant number of child deaths and complications due to ill health. This study aims to determine factors affecting health seeking behavior (HSB for childhood illnesses, thereby improving child survival. Methods: A cross sectional study was carried out from January 11 to April 2, 2012. A total of 212 caretakers of children under the age of 5 years participated. Caretakers who visited the vaccination unit in the Shehair Health Center during the study period and had a child with a history of diarrhea, fever, cough, and/or difficulty of breathing during the last 14 days were included. The data were collected by interviewing caretakers and the answers were reported in pretested structured questionnaires. Results: Medical care was sought for about half of the sick children (n=109, 51.42%. Seeking medical care was frequently initiated for illnesses that did not improve or worsened. The major reasons for not seeking medical care were "illness was mild" (n=40, 38.83% and "illness is not for medical treatment" (n=32, 31.07%. The caretakers sought medical care significantly more when they had a higher level of school education (POR [prevalence odds ratio] 5.85, 95% CI [confidence interval]: 2.34–14.61, when the illness was perceived as severe (POR 5.39, 95% CI: 2.81–10.33, and when the child had difficulty of breathing (POR 2.93, 95% CI: 1.10–7.80. Conclusion: For the preventable childhood illnesses with existing interventions, appropriate HSB prevalence is low. Symptom type, caretakers' education, and perception of illness severity are the predictors of HSB. Educational improvement of the mothers, introduction of community based integrated management of childhood illness, and in-depth research are imperative to improve mothers' HSB

  11. Clinical efficacy of emollients in atopic dermatitis patients – relationship with the skin microbiota modification

    Directory of Open Access Journals (Sweden)

    Seité S

    2017-01-01

    Full Text Available Sophie Seité,1 Hana Zelenkova,2 Richard Martin3 1La Roche-Posay Dermatological Laboratories, Asnières, France; 2DOST, Private Clinic of Dermatovenereology, Svidnik, Slovakia; 3L’Oréal Research and Innovation, Tours, France Background: We speculated that an emollient supplemented with a biomass of nonpathogenic bacteria such as Vitreoscilla filiformis (Vf, grown in a medium containing thermal spring water (LRP-TSW; (LRP-Vitreoscilla filiformis biomass [LRP-VFB], could have a beneficial effect for patients with atopic dermatitis (AD. Patients and methods: This double-blind, randomized, comparative study was conducted with 60 patients with moderate AD. Before starting the study, participants were pretreated for 15 days with drug therapy to improve their SCORing Atopic Dermatitis (SCORAD by at least 25%. On Day 1, the eligible patients were randomized to either the emollient containing LRP-VFB associated with mannose (Product A or another emollient (product B and were treated twice daily for 1 month. Recurrence of flare-ups and microbial communities were characterized from swabs taken at Day 1 and Day 28, under axenic conditions, from affected (AF and proximal unaffected (UAF skin areas. Results: At Day 1, the average SCORAD of each group and the microbial communities of AF and UAF areas for each participant were similar. One month after the end of the therapeutic treatment (Day 28, the average evolution of SCORAD at Day 28 compared to Day 1 of patients treated with product A was significantly lower than that of the patients treated with product B. A significantly increased level of Xanthomonas genus was noticed in the group treated with product A (versus product B. On the other hand, the level of Staphylococcus genus increased between Day 1 and Day 28 in the group treated with product B, but not in the group treated with product A. Interestingly, these differences were more pronounced for patients in relapse, and the associated SCORAD

  12. COPD management costs according to the frequency of COPD exacerbations in UK primary care

    Directory of Open Access Journals (Sweden)

    Punekar YS

    2014-01-01

    Full Text Available Yogesh Suresh Punekar,1 Amit Shukla,2 Hana Müllerova31Global Health Outcomes, GlaxoSmithKline R&D, Uxbridge, UK; 2Worldwide Epidemiology, GlaxoSmithKline R&D, Upper Providence, PA, USA; 3Worldwide Epidemiology, GlaxoSmithKline R&D, Uxbridge, UKBackground: The economic burden of chronic obstructive pulmonary disease (COPD exacerbations is significant, but the impact of other sources on the overall cost of COPD management is largely unknown. We aimed to estimate overall costs for patients experiencing none, one, or two or more exacerbations per year in the UK.Methods: A retrospective cohort of prevalent COPD patients was identified in the Clinical Practice Research Datalink UK database. Patients with information recorded for at least 12 months before and after cohort entry date were included (first prevalent COPD diagnosis confirmed by spirometry on/after April 1, 2009. Patients were categorized as having none, one, or two or more moderate-to-severe COPD exacerbations in the 12 months after cohort entry and further classified by the Global initiative for chronic Obstructive Lung Disease (GOLD category of airflow obstruction and the Medical Research Council dyspnea scale. Study outcomes included counts of general practitioner interactions, moderate-severe COPD exacerbations, and non-COPD hospitalizations. Estimated resource use costs were calculated using National Health Service reference costs for 2010–2011.Results: The cohort comprised 58,589 patients (mean age 69.5 years, mean dyspnea grade 2.5, females 46.6%, current smokers 33.1%. The average total annual per patient cost of COPD management, excluding medications, was £2,108 for all patients and £1,523, £2,405, and £3,396 for patients experiencing no, one, or two or more moderate-to-severe exacerbations, respectively. General practitioner interactions contributed most to these annual costs, accounting for £1,062 (69.7%, £1,313 (54.6%, and £1,592 (46.9% in patients with no, one, or

  13. Dissatisfaction with own body makes patients with eating disorders more sensitive to pain

    Directory of Open Access Journals (Sweden)

    Yamamotova A

    2017-07-01

    Full Text Available Anna Yamamotova,1 Josef Bulant,2 Vaclav Bocek,3 Hana Papezova2 1Department of Normal, Pathological and Clinical Physiology, Third Faculty of Medicine, 2Department of Psychiatry, First Faculty of Medicine, 3Department of Neurology, Third Faculty of Medicine, Charles University, Prague, Czech Republic Abstract: Body image represents a multidimensional concept including body image evaluation and perception of body appearance. Disturbances of body image perception are considered to be one of the central aspects of anorexia nervosa and bulimia nervosa. There is growing evidence that body image distortion can be associated with changes in pain perception. The aim of our study was to examine the associations between body image perception, body dissatisfaction, and nociception in women with eating disorders and age-matched healthy control women. We measured body dissatisfaction and pain sensitivity in 61 patients with Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition diagnoses of eating disorders (31 anorexia nervosa and 30 bulimia nervosa and in 30 healthy women. Thermal pain threshold latencies were evaluated using an analgesia meter and body image perception and body dissatisfaction were assessed using Anamorphic Micro software (digital pictures of their own body distorted into larger-body and thinner-body images. Patients with eating disorders overestimated their body size in comparison with healthy controls, but the two groups did not differ in body dissatisfaction. In anorexia and bulimia patient groups, body dissatisfaction (calculated in pixels as desired size/true image size correlated with pain threshold latencies (r=0.55, p=0.001, while between body image perception (determined as estimation size/true image size and pain threshold, no correlation was found. Thus, we demonstrated that in patients with eating disorders, pain perception is significantly associated with emotional contrary to sensory (visual processing of one

  14. Low pathogenic influenza A virus activity at avian interfaces in Ohio zoos, 2006-2009.

    Science.gov (United States)

    Nolting, Jacqueline M; Dennis, Patricia; Long, Lindsey; Holtvoigt, Lauren; Brown, Deniele; King, Mary Jo; Shellbarger, Wynonna; Hanley, Chris; Killian, Mary Lea; Slemons, Richard D

    2013-09-01

    This investigation to examine influenza A virus activity in avian species at four Ohio zoos was initiated to better understand the ecology of avian-origin influenza A (AIV) virus in wild aquatic birds and the possibility of spill-over of such viruses into captive zoo birds, both native and foreign species. Virus isolation efforts resulted in the recovery of three low pathogenic (LP) AIV isolates (one H7N3 and two H3N6) from oral-pharyngeal or cloacal swabs collected from over 1000 zoo birds representing 94 species. In addition, 21 LPAIV isolates possessing H3N6, H4N6, or H7N3 subtype combinations were recovered from 627 (3.3%) environmental fecal samples collected from outdoor habitats accessible to zoo and wild birds. Analysis of oral-pharyngeal and cloacal swabs collected from free-ranging mallards (Anas platyrhynchos) live-trapped at one zoo in 2007 resulted in the recovery of 164 LPAIV isolates (48% of samples) representing five HA and six NA subtypes and at least nine HA-NA combinations. The high frequency of isolate recovery is undoubtedly due to the capture and holding of wild ducks in a common pen before relocation. Serologic analyses using an agar gel immune diffusion assay detected antibodies to the influenza A virus type-specific antigen in 147 of 1237 (11.9%) zoo bird sera and in 14 of 154 (9%) wild mallard sera. Additional analyses of a limited number of zoo bird sera demonstrated HA- and NA-inhibition activity to 15 HA and nine NA subtypes. The spectrum of HA antibodies indicate antibody diversity of AIV infecting zoo birds; however, the contribution of heterologous cross-reactions and steric interference was not ruled out. This proactive investigation documented that antigenically diverse LPAIVs were active in all three components of the avian zoologic-wild bird interfaces at Ohio zoos (zoo birds, the environment, and wild birds). The resulting baseline data provides insight and justification for preventive medicine strategies for zoo birds.

  15. Coordination of International Risk-Reduction Investigations by the Multilateral Human Research Panel for Exploration

    Science.gov (United States)

    Charles, John B.; Bogomolov, Valery V.

    2015-01-01

    Effective use of the unique capabilities of the International Space Station (ISS) for risk reduction on future deep space missions involves preliminary work in analog environments to identify and evaluate the most promising techniques, interventions and treatments. This entails a consolidated multinational approach to biomedical research both on ISS and in ground analogs. The Multilateral Human Research Panel for Exploration (MHRPE) was chartered by the five ISS partners to recommend the best combination of partner investigations on ISS for risk reduction in the relatively short time available for ISS utilization. MHRPE will also make recommendations to funding agencies for appropriate preparatory analog work. In 2011, NASA's Human Research Program (HRP) and the Institute of Biomedical Problems (IBMP) of the Russian Academy of Science, acting for MHRPE, developed a joint US-Russian biomedical program for the 2015 one-year ISS mission (1YM) of American and Russian crewmembers. This was to evaluate the possibilities for multilateral research on ISS. An overlapping list of 16 HRP, 9 IBMP, 3 Japanese, 3 European and 1 Canadian investigations were selected to address risk-reduction goals in 7 categories: Functional Performance, Behavioral Health, Visual Impairment, Metabolism, Physical Capacity, Microbial and Human Factors. MHRPE intends to build on this bilateral foundation to recommend more fully-integrated multilateral investigations on future ISS missions commencing after the 1YM. MHRPE has also endorsed an on-going program of coordinated research on 6-month, one-year and 6-week missions ISS expeditions that is now under consideration by ISS managers. Preparatory work for these missions will require coordinated and collaborative campaigns especially in the psychological and psychosocial areas using analog isolation facilities in Houston, Köln and Moscow, and possibly elsewhere. The multilateral Human Analogs research working group (HANA) is the focal point of those

  16. Efficacy and safety of prolonged-release melatonin in insomnia patients with diabetes: a randomized, double-blind, crossover study

    Directory of Open Access Journals (Sweden)

    Garfinkel D

    2011-08-01

    Full Text Available Doron Garfinkel1, Mariana Zorin2, Julio Wainstein2, Zipora Matas3, Moshe Laudon4, Nava Zisapel4,51Geriatric Palliative Department, Shoham Geriatric Medical Center, Pardes Hana, Israel; 2Diabetes Unit, 3Biochemistry Laboratory, The E Wolfson Medical Center, Holon, Israel; 4Neurim Pharmaceuticals Ltd, 5Department of Neurobiology, Tel Aviv University, Tel Aviv, IsraelBackground: Diabetes is a major comorbidity in insomnia patients. The efficacy and safety of prolonged-release melatonin 2 mg in the treatment of glucose, lipid metabolism, and sleep was studied in 36 type 2 diabetic patients with insomnia (11 men, 25 women, age 46–77 years.Methods: In a randomized, double-blind, crossover study, the subjects were treated for 3 weeks (period 1 with prolonged-release melatonin or placebo, followed by a one-week washout period, and then crossed over for another 3 weeks (period 2 of treatment with the other preparation. All tablets were taken 2 hours before bedtime for a period of 3 weeks. In an extension period of 5 months, prolonged-release melatonin was given nightly to all patients in an open-label design. Sleep was objectively monitored in a subgroup of 22 patients using wrist actigraphy. Fasting glucose, fructosamine, insulin, C-peptide, triglycerides, total cholesterol, high-density and low-density lipoprotein cholesterol, and some antioxidants, as well as glycosylated hemoglobin (HbA1c levels were measured at baseline and at the end of the study. All concomitant medications were continued throughout the study.Results: No significant changes in serum glucose, fructosamine, insulin, C-peptide, antioxidant levels or blood chemistry were observed after 3 weeks of prolonged-release melatonin treatment. Sleep efficiency, wake time after sleep onset, and number of awakenings improved significantly with prolonged-release melatonin as compared with placebo. Following 5 months of prolonged-release melatonin treatment, mean HbA1c (±standard deviation was

  17. 浙江省首例人感染H7N9禽流感病例的实验室检测与分析%Detection and molecular characterization of novel avian-origin influenza A (H7N9) virus isolated from the first human case in Zhejiang

    Institute of Scientific and Technical Information of China (English)

    孙永祥; 陈棋炯; 李钧; 于新芬; 潘劲草

    2013-01-01

    Objective To detect and analyze the throat swab and nasal cavity lavaging fluid samples from one suspected human avian influenza in Xiaoshan,in order to deepen the understanding of the antigenic variation characteristics of influenza A virus,and to strengthen laboratory diagnostic ability.Methods The influenza virus nucleic acid from the samples were detected by real-time fluorescent quantitative PCR (real-time PCR).In addition,unallocated HA,NA and M genes were amplified by reverse transcription PCR (RT-PCR) and sequenced after cloning.Meanwhile,MDCK cells were inoculated with the sample for viral culturing.Results RNA extracted from the sample was positive for influenza A virus nucleic acid,but could not be typed.Furthermore,the results of gene sequencing revealed that the HA,NA,M genes were most closely related to H7,N9,M genes of avian origin,respectively,and the viral culturing was also positive for influenza A virus.Conclusions The patient was infected with a novel avian-origin influenza A (H7N9) virus,and was the first case in Zhejiang Province.%目的 通过对杭州市萧山区1例疑似人感染禽流感病人咽拭子和鼻腔冲洗液样本进行检测和分析,加深对A型流感病毒抗原变异特性的认识,进一步提高实验室相应的检测能力.方法 以实时荧光定量PCR(real-time PCR)检测流感病毒核酸,对未能分型的HA、NA和M基因通过逆转录PCR(RT-PCR)扩增而后克隆测定;同时接种狗肾细胞(MDCK)进行病毒培养.结果 样本A型流感病毒核酸检测为阳性,但未能分型;HA、NA、M基因测序结果表明与禽源H7、N9、M基因相似性最高;同时A型流感病毒培养也呈阳性.结论 经过浙江省CDC与中国CDC证实,该患者感染H7N9禽流感病毒,为浙江省首个病例.

  18. Sigríður Dúna Kristmundsdóttir: Ólafía - ævisaga Ólafíu Jóhannsdóttur

    Directory of Open Access Journals (Sweden)

    Auður Styrkársdóttir

    2006-12-01

    Full Text Available Fimm ár eru liðin frá því bók Sigríðar Dúnu Kristmundsdóttur um Björgu C. Þorláksson kom út og sópaði til sín bæði lesendum og verðlaunum. Margir hafa beðið næstu bókar með eftirvæntingu, en ljóst var að hún myndi borin saman við Björgu og kannski dæmd af því fyrst og fremst - með réttu eða röngu. Og nú er bókin semsé komin. Hún er hálft sjötta hundrað blaðsíður og fylgir settum reglum um fræðilegan frágang sem truflar þó ekkert textann. Pappírinn í bókinni er mjög lesvænn og metnaður af hálfu útgáfunnar augljóslega mikill. Ljósmyndir eru fjölmargar og setja skemmtilegan svip á bókina. Kápumynd er einföld og grípandi og ljósmyndin sem prýðir hana er vel valin. Um varir konunnar leikur hálfgert Mónu Lísu bros - eins og hún viti eitthvað merkilegt og sé rétt í þann mund að opinbera þá vitneskju. Bókin Ólafía býður upp á nánari kynni af margbrotinni persónu, sem einnig var afar brothætt og farnaðist misvel í lífsins ólgusjó.

  19. Ráðskast með stjórnarskrá

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    Gunnar Helgi Kristinsson

    2012-12-01

    Full Text Available Úr niðurstöðum: Að mínu viti er augljóst að niðurstaðan er hvorki nægilega upplýst né um hana nægileg samstaða til að hægt sé að setja lokapunkt við ferlið. Stór hluti hinnar sérfræðilegu vinnu er eftir, þar á meðal mat á einstökum tillögum og samhengi þeirra. En það skiptir líka máli að stór hluti hinnar pólitísku vinnu er eftir. Víða eru gerðar sérstakar kröfur til stjórnarskrárbreytinga um aukinn meirihluta til að stuðla að breiðri samstöðu um niðurstöðurnar. Á Íslandi virðist hins vegar ferlið hafa verið hannað til að koma í veg fyrir aðkomu þeirra sem höfðu efasemdir um róttæka uppstokkun stjórnarskrárinnar. Aftanmálsgrein: Upphaflega flutt sem erindi á ráðstefnu Háskóla Íslands í samvinnu við háskólana á Bifröst, Reykjavík og Akureyri föstudaginn 9. nóvember 2012 "Eru þingmenn bundnir af niðurstöðu þjóðaratkvæðagreiðslu um breytingar á íslensku stjórnarskránni?" Heiti erindisins var "Á byrjunarreit eða í endatafli: Hvar stendur stjórnarskrárvinnan?"

  20. In vitro cytotoxicity analysis of doxorubicin-loaded/superparamagnetic iron oxide colloidal nanoassemblies on MCF7 and NIH3T3 cell lines

    Directory of Open Access Journals (Sweden)

    Tomankova K

    2015-01-01

    Full Text Available Katerina Tomankova,1 Katerina Polakova,2 Klara Pizova,1 Svatopluk Binder,1 Marketa Havrdova,2 Mary Kolarova,2 Eva Kriegova,3 Jana Zapletalova,1 Lukas Malina,1 Jana Horakova,1 Jakub Malohlava,1 Argiris Kolokithas-Ntoukas,4 Aristides Bakandritsos,4 Hana Kolarova,1 Radek Zboril2 1Department of Medical Biophysics, Institute of Translation Medicine, Faculty of Medicine and Dentistry, 2Regional Centre of Advanced Technologies and Materials, Departments of Physical Chemistry and Experimental Physics, Faculty of Science, 3Department of Immunology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; 4Department of Materials Science, University of Patras, Patras, Greece Abstract: One of the promising strategies for improvement of cancer treatment is based on magnetic drug delivery systems, thus avoiding side effects of standard chemotherapies. Superparamagnetic iron oxide (SPIO nanoparticles have ideal properties to become a targeted magnetic drug delivery contrast probes, named theranostics. We worked with SPIO condensed colloidal nanocrystal clusters (MagAlg prepared through a new soft biomineralization route in the presence of alginate as the polymeric shell and loaded with doxorubicin (DOX. The aim of this work was to study the in vitro cytotoxicity of these new MagAlg–DOX systems on mouse fibroblast and breast carcinoma cell lines. For proper analysis and understanding of cell behavior after administration of MagAlg–DOX compared with free DOX, a complex set of in vitro tests, including production of reactive oxygen species, comet assay, cell cycle determination, gene expression, and cellular uptake, were utilized. It was found that the cytotoxic effect of MagAlg–DOX system is delayed compared to free DOX in both cell lines. This was attributed to the different mechanism of internalization of DOX and MagAlg–DOX into the cells, together with the fact that the drug is strongly bound on the drug nanocarriers. We

  1. Envisioning the Shôjo Aesthetic in Illustrations of Miyazawa Kenji’s Literature.

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    Helen Claire Kilpatrick

    2013-01-01

    Full Text Available Despite an ever-growing body of scholarship on the shôjo (girl in manga and anime, little has been written about representations of the ‘girl’ in Japanese picture books. Shôjo literature and culture have grown exponentially in Japan since about the 1980s, but there has been a tendency in popular media to overemphasise the 'cute', disempowering aspects of the ‘girl’. By using Takahara Eiri's (1999 concept of “girl consciousness” and Honda Masuko's (1992 envisioning of the girl’s imagined freedom through a hirahira (fluttering aesthetic, notions of the powerless or mindlessly consuming shôjo can be dispelled. Such concepts help demonstrate that the girl ‘has her own creative, critical and cultural, if not social or political, power’ (Aoyama 2008: 286. This paper examines the shôjo tropes in contemporary illustrations that were produced to accompany two tales by the renowned author Miyazawa Kenji (1896-1933, Futago no Hoshi (Twin Stars and Ginga Tetsudô no Yoru (Night of the Milky Way Railway. Although Kenji (as he is known is not generally considered a shôjo author, some of his works incorporate gently transgressive shôjo themes reminiscent of, for example, Yoshiya Nobuko’s Hana Monogatari (Flower Tales from the 1920s. I argue that the current artwork of two award-winning artists, Makino Suzuko and Azuma Itsuko, reflects and enhances Kenji’s ‘girlish’ verbal images, bringing them to the fore in their accompanying imagery for Futago and Ginga by drawing on shôjo art, manga and literature. The artists thus bring into play intertextual references that occur not only across different historical temporalities but also through relations between the author, the artist, the text(s, the protagonists and the reading/viewing audience. The analysis of their striking artwork shows how they bring Kenji’s 1920s’ works firmly into the arena of the contemporary ‘girl’, expanding the abstract consciousness of the sh

  2. Relationship between remnant hippocampus and amygdala and memory outcomes after stereotactic surgery for mesial temporal lobe epilepsy

    Directory of Open Access Journals (Sweden)

    Malikova H

    2015-11-01

    Full Text Available Hana Malikova,1,2,* Lenka Kramska,3,* Zdenek Vojtech,4,5 Jan Sroubek,6 Jiri Lukavsky,7 Roman Liscak8 1Department of Radiology, Na Homolce Hospital, 2Institute of Anatomy, Second Medical Faculty, Charles University in Prague, 3Department of Clinical Psychology, Na Homolce Hospital, 4Department of Neurology, Na Homolce Hospital, 5Department of Neurology, 3rd Medical Faculty, Charles University in Prague, 6Department of Neurosurgery, Na Homolce Hospital, 7Institute of Psychology, Academy of Sciences of the Czech Republic, 8Department of Radiation and Stereotactic Neurosurgery, Na Homolce Hospital, Prague, Czech Republic *These authors contributed equally to this work Background and purpose: Mesial temporal structures play an important role in human memory. In mesial temporal lobe epilepsy (MTLE, seizure activity is generated from the same structures. Surgery is the definitive treatment for medically intractable MTLE. In addition to standard temporal lobe microsurgical resection, stereotactic radiofrequency amygdalohippocampectomy (SAHE is used as an alternative MTLE treatment. While memory impairments after standard epilepsy surgery are well known, it has been shown that memory decline is not a feature of SAHE. The aim of the present study was to correlate the volume of the remnant hippocampus and amygdala in patients treated by SAHE with changes in memory parameters.Materials and methods: Thirty-seven MTLE patients treated by SAHE (ten right, 27 left were included. Patients underwent magnetic resonance imaging examinations including hippocampal and amygdalar volumetry and neuropsychological evaluation preoperatively and 1 year after surgery.Results: Using Spearman correlation analyses, larger left-sided hippocampal reductions were associated with lower verbal memory performance (ρ=-0.46; P=0.02. On the contrary, improvement of global memory quotient (MQ was positively correlated with larger right-sided hippocampal reduction (ρ=0.66; P=0

  3. Molecular evolutionary analysis of pH1N1 2009 influenza virus in Reunion Island, South West Indian Ocean region: a cohort study.

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    Hervé Pascalis

    Full Text Available BACKGROUND/OBJECTIVES: Molecular epidemiology is a powerful tool to decipher the dynamics of viral transmission, quasispecies temporal evolution and origins. Little is known about the pH1N1 molecular dynamics in general population. A prospective study (CoPanFlu-RUN was carried out in Reunion Island to characterize pH1N1 genetic variability and molecular evolution occurring in population during the pH1N1 Influenza pandemic in 2009. METHODOLOGY: We directly amplified pH1N1 genomes from 28 different nasal swabs (26 individuals from 21 households. Fifteen strains were fully sequenced and 13 partially. This includes pairs of sequences from different members of 5 separate households; and two pairs from individuals, collected at different times. We assessed the molecular evolution of pH1N1 by genetic variability and phylogenetic analyses. PRINCIPAL FINDINGS: We found that i Reunion pH1N1 sequences stemmed from global "clade 7" but shaped two phylogenetic sub-clades; ii D239E mutation was identified in the hemagglutinin protein of all Reunion sequences, a mutation which has been associated elsewhere with mild-, upper-respiratory tract pH1N1 infecting strains; iii Date estimates from molecular phylogenies predicted clade emergence some time before the first detection of pH1N1 by the epidemiological surveillance system; iv Phylogenetic relatedness was observed between Reunion pH1N1 viruses and those from other countries in South-western Indian Ocean area; v Quasispecies populations were observed within households and individuals of the cohort-study. CONCLUSIONS: Surveillance and/or prevention systems presently based on Influenza virus sequence variation should take into account that the majority of studies of pH1N1 Influenza generate genetic data for the HA/NA viral segments obtained from hospitalized-patients, which is potentially non-representative of the overall viral diversity within whole populations. Our observations highlight the importance of

  4. Influenza-A viruses in ducks in northwestern Minnesota: fine scale spatial and temporal variation in prevalence and subtype diversity.

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    Benjamin R Wilcox

    Full Text Available Waterfowl from northwestern Minnesota were sampled by cloacal swabbing for Avian Influenza Virus (AIV from July-October in 2007 and 2008. AIV was detected in 222 (9.1% of 2,441 ducks in 2007 and in 438 (17.9% of 2,452 ducks in 2008. Prevalence of AIV peaked in late summer. We detected 27 AIV subtypes during 2007 and 31 during 2008. Ten hemagglutinin (HA subtypes were detected each year (i.e., H1, 3-8, and 10-12 during 2007; H1-8, 10 and 11 during 2008. All neuraminidase (NA subtypes were detected during each year of the study. Subtype diversity varied between years and increased with prevalence into September. Predominant subtypes during 2007 (comprising ≥5% of subtype diversity included H1N1, H3N6, H3N8, H4N6, H7N3, H10N7, and H11N9. Predominant subtypes during 2008 included H3N6, H3N8, H4N6, H4N8, H6N1, and H10N7. Additionally, within each HA subtype, the same predominant HA/NA subtype combinations were detected each year and included H1N1, H3N8, H4N6, H5N2, H6N1, H7N3, H8N4, H10N7, and H11N9. The H2N3 and H12N5 viruses also predominated within the H2 and H12 subtypes, respectively, but only were detected during a single year (H2 and H12 viruses were not detected during 2007 and 2008, respectively. Mallards were the predominant species sampled (63.7% of the total, and 531 AIV were isolated from this species (80.5% of the total isolates. Mallard data collected during both years adequately described the observed temporal and spatial prevalence from the total sample and also adequately represented subtype diversity. Juvenile mallards also were adequate in describing the temporal and spatial prevalence of AIV as well as subtype diversity.

  5. The M segment of the 2009 pandemic influenza virus confers increased neuraminidase activity, filamentous morphology, and efficient contact transmissibility to A/Puerto Rico/8/1934-based reassortant viruses.

    Science.gov (United States)

    Campbell, Patricia J; Danzy, Shamika; Kyriakis, Constantinos S; Deymier, Martin J; Lowen, Anice C; Steel, John

    2014-04-01

    segment impacts the morphology of the influenza A virion and transmissibility of the virus in the guinea pig model. We suggest that changes in NA activity underlie the ability of the influenza M segment to influence virus transmissibility. Furthermore, we show that coadapted M, NA, and HA segments are required to provide optimal transmissibility to an influenza virus. The M-NA functional interaction we describe appears to underlie the prominent role of the 2009 pandemic M segment in supporting efficient transmission and may be a highly important means by which influenza A viruses restore HA/NA balance following reassortment or transfer to new host environments.

  6. Validity and interpretation of spirometric recordings to diagnose COPD in UK primary care

    Directory of Open Access Journals (Sweden)

    Rothnie KJ

    2017-06-01

    Full Text Available Kieran J Rothnie,1,2 Joht S Chandan,3,4 Harry G Goss,4,5 Hana Müllerová,6 Jennifer K Quint1,2 1Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, 2Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, 3Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham, Birmingham, 4Medical School, Faculty of Medical Sciences, University College London, 5Jersey General Hospital, St Helier, Jersey, 6Respiratory Epidemiology, GlaxoSmithKline R&D, Uxbridge, UK Background: The diagnosis of COPD is dependent upon clinical judgment and confirmation of the presence of airflow obstruction using spirometry. Spirometry is now routinely available; however, spirometry incorrectly performed or interpreted can lead to misdiagnosis. We aimed to determine whether spirometry undertaken in primary care for patients suspected to have COPD was of sufficient quality and whether their spirometry was correctly interpreted.Methods: Two chest physicians re-read all spirometric readings for both quality of the procedure and interpretation, received as a part of COPD validation studies using data from the Clinical Practice Research Datalink (CPRD. We then used logistic regression to investigate predictors of correct interpretation.Results: Spirometry traces were obtained for 306 patients, of which 221 (72.2% were conducted in primary care. Of those conducted in primary care, 98.6% (n=218 of spirometry traces were of adequate quality. Of those traces that were of adequate quality and conducted in primary care, and in whom a general practitioner (GP diagnosis of COPD had been made, 72.5% (n=218 were consistent with obstruction. Historical records for asthma diagnosis significantly decreased odds of correct interpretation.Conclusion: The quality of the spirometry procedure undertaken in primary care is high. However, this was not reflected in the

  7. Interim Report on Design, Fabrication and Test of HANARO Instrumented Capsule (07M-13N) for the Researches of Irradiation Performance of Parts of X-Gen Nuclear Fuel Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Choo, K. N.; Kim, B. G.; Kang, Y. H.; Choi, M. H.; Cho, M. S.; Son, J. M.; Shin, Y. T.; Park, S. J.; Seo, C. G.; Kim, S. H.; Lee, J. H

    2008-02-15

    An instrumented capsule of 07M-13N was designed, fabricated and irradiated for and evaluation of the neutron irradiation properties of the parts of a a X-Gen nuclear fuel assembly for PWR requested by KNF (Korea Nuclear Fuel). The basic structure of the 07M-13N capsule was based on the 05M-07U capsule in which similar materials has been successfully irradiated in HANARO in 2006. Some specimens of control rod materials of AP1000 reactor requested by Westinghouse Co. were inserted in this capsule as a preliminary irradiation test and Polyimide specimens requested by Hanyang university were also inserted. 463 specimens such as bucking and spring test specimens of 1x1 cell spacer grid, tensile, microstructure and tensile of welded parts, irradiation growth, spring test specimens made of HANA tube, Zirlo, Zircaloy-4, Inconel-718, Polyimide, Ag and Ag-In-Cd alloys were placed in the capsule. The capsule was composed of 5 stages having many kinds of specimens and an independent electric heater at each stage. During the irradiation test, the temperature of the specimens and the thermal/fast neutron fluences were measured by 14 thermocouples and 7 sets of Ni-Ti-Fe neutron fluence monitors installed in the capsule. A new friction welded tube between STS304 and Al1050 alloys was introduced in the capsule to prevent a coolant leakage into a capsule during a capsule cutting process in HANARO. The capsule was irradiated for 49days (2 cycles) in the CT test hole of HANARO of a 30MW thermal output at 295 {approx} 460 .deg. C and maintained in the service pool because of reactor shut-down for the FTL construction. The specimen will be irradiated up to a maximum fast neutron fluence of 1.2x10{sup 21}(n/cm{sup 2}) (E>1.0MeV) after 4 cycle irradiation. The obtained results will be very valuable for the related researches of the users.

  8. Characteristics of patients with COPD newly prescribed a long-acting bronchodilator: a retrospective cohort study

    Directory of Open Access Journals (Sweden)

    Wurst KE

    2014-09-01

    Full Text Available Keele E Wurst,1 Samantha St Laurent,1 Hana Mullerova,2 Kourtney J Davis3 1Worldwide Epidemiology, GlaxoSmithKline R&D, Research Triangle Park, NC, USA; 2Worldwide Epidemiology, GlaxoSmithKline R&D, Uxbridge, UK; 3Worldwide Epidemiology, GlaxoSmithKline R&D, Wavre, Belgium Introduction: This study aimed to characterize patients with chronic obstructive pulmonary disease (COPD newly prescribed a long-acting bronchodilator (LABD, and to assess changes in medication over 24 months. Methods: A cohort of patients with COPD aged ≥40 years newly prescribed an LABD between January 1, 2007 and December 31, 2009 were identified from the Truven Marketscan® Commercial Database (Truven Health Analytics, Ann Arbor, MI, USA and followed for 24 months. Inclusion criteria included no prior prescription for an LABD or inhaled corticosteroids for 12 months prior to the LABD index date (baseline. Patient characteristics were examined. As LABDs were mainly long-acting muscarinic antagonists (LAMAs, additions, switches, discontinuation, adherence to (medication possession ratio, and persistence (proportion of days covered with LAMA monotherapy were assessed for 24 months following the index date. Adherence and persistence with long-acting β2-agonists (LABAs were also assessed. Results: A cohort of 3,268 patients aged 40–65 years was identified (mean age 55.8 years, 48% male. LAMA monotherapy was prescribed to 93% of patients who received an LABD. During the 24-month follow-up, 16% of these patients added COPD medication, 10% switched to an inhaled corticosteroid-containing medication, and 25% discontinued after one LAMA prescription at baseline. Over 12 and 24 months, adherence to LAMA was 40% and 33%, respectively, and adherence to LABA was 29% and 24%, respectively. Over the same time periods, persistence with LAMA monotherapy was 19% and 15%, respectively, and persistence with LABA was 9% and 7%, respectively. Conclusion: Adherence to newly initiated LAMA

  9. Prediction of population with Alzheimer's disease in the European Union using a system dynamics model

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    Tomaskova H

    2016-06-01

    Full Text Available Hana Tomaskova,1 Jitka Kuhnova,2 Richard Cimler,1,3 Ondrej Dolezal,1 Kamil Kuca3 1Faculty of Informatics and Management, 2Faculty of Science, 3Center for Basic and Applied Research (CZAV, University of Hradec Králové, Hradec Králové, Czech Republic Introduction: Alzheimer’s disease (AD is a slowly progressing neurodegenerative brain disease with irreversible brain effects; it is the most common cause of dementia. With increasing age, the probability of suffering from AD increases. In this research, population growth of the European Union (EU until the year 2080 and the number of patients with AD are modeled.Aim: The aim of this research is to predict the spread of AD in the EU population until year 2080 using a computer simulation.Methods: For the simulation of the EU population and the occurrence of AD in this population, a system dynamics modeling approach has been used. System dynamics is a useful and effective method for the investigation of complex social systems. Over the past decades, its applicability has been demonstrated in a wide variety of applications. In this research, this method has been used to investigate the growth of the EU population and predict the number of patients with AD. The model has been calibrated on the population prediction data created by Eurostat.Results: Based on data from Eurostat, the EU population until year 2080 has been modeled. In 2013, the population of the EU was 508 million and the number of patients with AD was 7.5 million. Based on the prediction, in 2040, the population of the EU will be 524 million and the number of patients with AD will be 13.1 million. By the year 2080, the EU population will be 520 million and the number of patients with AD will be 13.7 million.Conclusion: System dynamics modeling approach has been used for the prediction of the number of patients with AD in the EU population till the year 2080. These results can be used to determine the economic burden of the treatment of

  10. Age at diagnosis of autism spectrum disorders: is there an association with socioeconomic status and family self-education about autism?

    Directory of Open Access Journals (Sweden)

    Hrdlicka M

    2016-07-01

    Full Text Available Michal Hrdlicka,1 Maria Vacova,1 Hana Oslejskova,2 Veronika Gondzova,2 Iveta Vadlejchova,3 Jana Kocourkova,1 Jiri Koutek,1 Iva Dudova1 1Department of Child Psychiatry, Charles University Second Faculty of Medicine and University Hospital Motol, Prague, 2Department of Child Neurology, Masaryk University Faculty of Medicine and University Hospital, Brno, 3Child Psychiatry Clinic, Chomutov, Czech Republic Background: The marked increase in autism spectrum disorders (ASD prevalence has stimulated worldwide interest in exploring broader circumstances of care of autistic children, including the role of socioeconomic status (SES and family information on autism.Methods: Our sample comprised of 160 children who participated in a diagnostic examination focused on autism, and their parents who completed a simple descriptive questionnaire focusing on the family situation as well as family self-education about autism. The diagnosis of ASD was confirmed in 120 children (75% of the sample; 94 boys, 26 girls with mean age 6.2±2.7 years (median 5.3, range 2.2–17.2 years. In 71 autistic patients (59.2%, a diagnosis of mental retardation was also established.Results: The age at diagnosis of ASD correlated negatively with maternal (P=0.014 and paternal (P=0.002 ages at the time of birth of the ASD child as well as with paternal (P=0.002 and maternal (P=0.050 education. The age at diagnosis of ASD did not correlate with family SES. Mothers were significantly more active in seeking information on autism than fathers or both parents equally (80 vs 9 vs 28 cases, respectively; P<0.001. The mean number of information sources on autism was 3.5±1.8 with a range 0–9. The mean number of resources did not differ among the three SES groups (3.50 vs 3.49 vs 4.25, respectively; P=0.704. The mean number of sources did not correlate with the age at diagnosis of ASD. The most often used sources were the Internet (81.7%, followed by psychologists (48.3%, books (46.7%, and

  11. Spontaneous release of epiretinal membrane in a young weight-lifting athlete by presumed central rupture and centrifugal pull

    Directory of Open Access Journals (Sweden)

    Mansour AM

    2014-11-01

    Full Text Available Ahmad M Mansour,1,2 Hana A Mansour,3 J Fernando Arevalo4,5 1Department of Ophthalmology, Rafic Hariri University Hospital, Beirut, Lebanon; 2Department of Ophthalmology, American University of Beirut, Beirut, Lebanon; 3Department of Biology, American University of Beirut, Beirut, Lebanon; 4Retina Department, The King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia; 5Retina Department, Wilmer Eye Institute, The Johns Hopkins University, Baltimore, MD, USA Abstract: This patient presented for surgery at the age of 32 years, 14 months after his initial complaint of metamorphopsia and visual loss in the right eye. Past tests demonstrated a whitish epiretinal membrane (ERM with translucent stress lines over a thickened macula. Visual acuity was found on last presentation to be normal with minimal alteration on Amsler grid testing. A torn ERM was found in the center with left-over ERM temporally and rolled-over ERM nasally at the site of the epicenter with no posterior vitreous detachment. Visual recovery occurred gradually over several days 2 months prior to presentation apparently following heavy weight-lifting with a sensation of severe eye pressure. Sequential funduscopy and optical coherence tomography scans demonstrated the peeling of an ERM accompanied by normalization of foveal thickness. Valsalva maneuver had put excessive tension on ERM which tore in its center at the weakest line with gradual contraction of the ERM away from the fovea towards the peripapillary area. This is a new mechanism of self-separation of ERM induced by Valsalva. ERM in young subjects is subject to rupture and subsequent separation by tangential traction. There are three mechanisms for spontaneous separation of ERM: 1 posterior vitreous detachment with pulling of ERM by detaching vitreous (most common in adults; 2 the contracting forces of the immature ERM become stronger than its adhesions to the retina resulting in slow tangential traction on the

  12. Hawaiian submarine manganese-iron oxide crusts - A dating tool?

    Science.gov (United States)

    Moore, J.G.; Clague, D.A.

    2004-01-01

    Black manganese-iron oxide crusts form on most exposed rock on the ocean floor. Such crusts are well developed on the steep lava slopes of the Hawaiian Ridge and have been sampled during dredging and submersible dives. The crusts also occur on fragments detached from bedrock by mass wasting, on submerged coral reefs, and on poorly lithified sedimentary rocks. The thickness of the crusts was measured on samples collected since 1965 on the Hawaiian Ridge from 140 dive or dredge localities. Fifty-nine (42%) of the sites were collected in 2001 by remotely operated vehicles (ROVs). The thinner crusts on many samples apparently result from post-depositional breakage, landsliding, and intermittent burial of outcrops by sediment. The maximum crust thickness was selected from each dredge or dive site to best represent crusts on the original rock surface at that site. The measurements show an irregular progressive thickening of the crusts toward the northwest-i.e., progressive thickening toward the older volcanic features with increasing distance from the Hawaiian hotspot. Comparison of the maximum crust thickness with radiometric ages of related subaerial features supports previous studies that indicate a crust-growth rate of about 2.5 mm/m.y. The thickness information not only allows a comparison of the relative exposure ages of two or more features offshore from different volcanoes, but also provides specific age estimates of volcanic and landslide deposits. The data indicate that some of the landslide blocks within the south Kona landslide are the oldest exposed rock on Mauna Loa, Kilauea, or Loihi volcanoes. Crusts on the floors of submarine canyons off Kohala and East Molokai volcanoes indicate that these canyons are no longer serving as channelways for downslope, sediment-laden currents. Mahukona volcano was approximately synchronous with Hilo Ridge, both being younger than Hana Ridge. The Nuuanu landslide is considerably older than the Wailau landslide. The Waianae

  13. Emissions from animal husbandry. Greenhouse gases, environmental assessment, state of the art; Emissionen der Tierhaltung. Treibhausgase, Umweltbewertung, Stand der Technik

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    : Nitrogen and phosphorus flows in pig production (Dennis Otten); (36) Seasonal effect on emissions of ammonia and greenhouse gases in fattening pigs (Zuzana Palkovicova); (37) Greenhouse gas emissions and evaluation of sustainability aspects in dairy farming - data collection on farms, modelling, life cycle assessment (Hans Marten Paulsen); (38) Methodology of a systematic cost-benefit analysis of mitigation strategies for emissions from livestock farming (Regina Roessler); (39) Measuring concept for the quantification of emissions from naturally ventilated housings for dairy cattle (Sabine Schrade); (40) Reduction of ammonia concentration in growing-finishing pigs with FRESTA {sup registered} F Plus (Martin Veit); (41) Measurements in and around intensive livestock farms: Dust, ammonia, greenhouse gases and bioaerosols (Heinz Riedel).

  14. The effects of hand2 knock-down on the zebrafish embryonic development%hand2基因对斑马鱼胚胎发育影响的实验研究

    Institute of Scientific and Technical Information of China (English)

    孙淑娜; 桂永浩; 宋后燕; 蒋璆; 王跃祥

    2008-01-01

    目的 观察hand2在斑马鱼胚胎内的表达情况,验证显微注射吗啡啉修饰的反义寡核苷酸(Morpholi-no oligonucleotides,MO)使hand2表达下调的有效性.观察hand2表达下调后斑马鱼胚胎发育的异常表型,初步探讨hand2在斑马鱼胚胎发育中的作用,为利用斑马鱼开展hand2的功能研究提供线索.方法 采用胚胎整体原位杂交的方法观察hand2在斑马鱼胚胎内的表达情况.利用向斑马鱼受精卵显微注射MO的方法使hand2表达下调,并进行hand2表达下调的效率验证.将斑马鱼单细胞受精卵分为4组进行显微注射,即对照MO(Con MO)注射组、hand2 MO注射组、hand2-GFP mRNA注射组和hand2-GFP mRNA+hand2 MO注射组.在荧光显微镜下观察hand2-GFP mRNA注射组和hand2-GFP mRNA+hand2 MO注射组的荧光表达情况以验证hand2表达下调的效率.在显微镜下观察hand2 MO注射组斑马鱼胚胎的各器官发育情况并进行评定.结果 hand2在斑马鱼胚胎的侧板中胚层、咽弓、心脏和鳍有较强表达.hand2-GFP mRNA注射组在8 hpf(hours post fertilization)时胚胎有较强的荧光表达,而hand2-GFP mRNA+hand2 MO注射组胚胎几乎无荧光表达.与Con MO注射组相比,hana2 MO注射组斑马鱼胚胎的心脏、血管、血细胞、鳍以及体节有明显的发育异常.结论 向斑马鱼受精卵显微注射hand2 MO的方法可有效的使hand2表达下调.hand2在斑马鱼胚胎的心脏、血管、血细胞、鳍以及体节的发育过程中有重要作用.

  15. The Kea- and Loa- trends and magma genesis in the Hawaiian mantle plume

    Science.gov (United States)

    Ren, Z.; Ingle, S.; Takahashi, E.; Hirano, N.; Hirata, T.; Tatsumi, Y.

    2005-12-01

    The Hawaiian-Emperor volcanic island and seamount chain has been created by a hot mantle plume located beneath the Pacific lithosphere. The shield volcanoes of the Hawaiian islands are distributed in two curvilinear parallel trends, termed _eKea_Eand _eLoa_E(Jackson et al., 1972). Lavas from these two trends are commonly believed to have different geochemical characteristics (Tatsumoto, 1978; Frey et al., 1994; Hauri, 1996; Lassiter et al., 1996; Abouchami et al., 2005). The Kea- and Loa- geochemical trends within the Hawaiian shield volcanoes have been interpreted to reflect melting above a compositionally concentrically zoned (Hauri, 1996; Lassiter et al., 1996; Kurz et al., 1996; DePaolo et al., 2001) or compositionally left-right asymmetrically zoned mantle plume (Abouchami et al., 2005). In order to evaluate the homogeneity of the mantle plume source sampled by the Kea- and Loa- trends, we analyzed major and trace element compositions of olivine-hosted melt inclusions from Hawaiian shield lavas, using EPMA and Laser ICP-MS. We selected lava samples form submarine Hana Ridge, Haleakala volcano (Kea trend) and submarine exposures of the Makapuu stage, Koolau volcano (Loa trend), respectively. We found both Kea- and Loa-like major and trace element compositions from olivine-hosted melt inclusions in individual, shield-stage Hawaiian volcanoes, even within single rock samples. We infer from these data that although one mantle source component may dominate a single lava flow, the two (or more) mantle source components are consistently represented to some extent in all lavas, regardless of the specific geographic location of the volcano. On the basis of whole rock geochemical characteristics (Ren et al., J. pet., 2004; 2005) combined with the melt inclusion data (Ren et al., 2005, Nature), we propose a Hawaiian mantle plume characterized by more random heterogeneity than would be present in a simple compositionally zoned mantle plume. The geochemical differences in

  16. A Comparison of Event Framing in Old Japanese and Old Chinese

    Directory of Open Access Journals (Sweden)

    Wenchao LI

    2011-12-01

    Full Text Available This paper brings data on Old Chinese and Old Japanese together in order to conduct an investigation into event-framing strategies. Old Chinese consists of a monosyllabic root with five constituents that express the path: (a particle, (b incorporated noun, (c preverb, (d verb root, and (e complement. Verb framing, satellite framing, and equipollent framingare all found in the data. Crucially, before the birth of disyllabic word roots and verb compounding in the Late Han Dynasty, verb framing seems to have been the main pattern. Throughout the transformation of the Chinese language, the use of incorporated nouns and preverbs denoting the path has declined, with the remaining particles serving motion events. This contributes to the contention that contemporary Chinese is a satellite-framed language. Meanwhile, verb complements emerged and played the main role in non-motion events. In terms of Old Japanese, all three event-framing patterns have been observed. Moreover, the path is denoted via three means: prefix, auxiliary, and verb compounding. Among them, verb compounding appears to play the most significant role. These distinct event-framing patterns both intralinguistic and crosslinguistic are based on the diversity of lexical resources of motion/non-motion event framing and preferences for event-encoding options by selecting different lexical resources.-----Članek proučuje strategije uokvirjanja dogodkov na osnovi gradiv iz stare kitajščine in japonščine. Staro kitajščino sestavlja pet tipov enozložnih korenov, ki izražajo sled: (a členek, (b inkorporirani samostalnik, (c predglagol, (d glagolski koren ter (e dopolnilo. V gradivu je mogoče najti uokvirjanje s pomočjo glagolov, uokvirjanje s pomočjo satelitov kot tudi uokvirjanje s pomočjo obojih (equipollent framing. Kar je pomembno, pred rojstvom dvozložnih besednih korenov in sestavljenih glagolov v obdobju Poznega Hana je kot kaže kot glavni tip prevladovalo uokvirjanje s

  17. 广东一株重组H9N2亚型禽流感病毒的鉴定及全基因组序列分析%Complete genomic evolutionary analysis of a reassortant H9N2 influenza virus isolated from poultry flocks in Guangdong

    Institute of Scientific and Technical Information of China (English)

    申翰钦; 曾凡桂; 严专强; 刘佳佳; 覃健萍; 毕英佐; 李海燕; 陈峰

    2013-01-01

    本研究于2013年从广东某发病鸡场分离到一株H9N2亚型AIV,命名为A/chicken/Guangdong/LG1/2013.对病毒进行全基因组克隆测序和进化分析,其HA基因裂解基序为333pSRSSR ↓ GLF341,呈典型低致病性AIV分子特征.其HA基因发生Q226突变和A316S突变,NA基因出现第63~65位氨基酸缺失.该病毒株HA、NA和NS基因属于类BJ/1/94分支,PB2属于类SD/H/09分支,PB1、PA、NP基因属于类SH/F/98分支,M基因属于类HK/G1/97分支,该基因型在广东地区未见报道,其内部基因与H7N9亚型人流感病毒SH/02/2013株核苷酸同源性在95.6 %~98.6%之间.本研究表明我国H9N2亚型AIV呈现遗传演化的多样性及基因重组的复杂性,对该亚型病毒的监测和研究具有重要的兽医和公共卫生意义.%To investigate the genetic and evolutionary characteristics of H9N2 avian influenza virus (AIV) in poultry flocks in Guangdong province,an H9N2 AIV was isolated and designated A/chicken/Guangdong/LG1/2013 (CK/GD/LG1/13).The phylogenetic and molecular characteristics of the isolate were analyzed.The HA cleavage sequence of the isolate possessed the 333pSRSSR ↓ GLF341 motif,suggesting that this isolate was of a low pathogenicity in avian species.However,this isolate had an A316S mutation at the HA cleavage site and a 3-amino-acid deletion at position 63 to 65 on the NA stalk,which indicated an enhanced virulence in chickens and mice.Furthermore,CK/GD/LG1/13 also had the Q226L mutation at HA receptor-binding site which could increase the binding of the virus to human-type receptors,SAα-2,6.The HA,NA and NS genes of the isolate belong to BJ/1/94-like lineage.The PB2 belongs to H-like and the M gene belongs to G1-like lineage,while the PB1,PA and NP genes belong to F98-1ike lineage.The genotype of the isolate in poultry flocks in Guangdong province has never been reported before.It is noteworthy that six internal genes of the isolate share 95.6%-98.6% nucleotide identities with

  18. Continuing to Confront COPD International Physician Survey: physician knowledge and application of COPD management guidelines in 12 countries

    Directory of Open Access Journals (Sweden)

    Davis KJ

    2014-12-01

    Full Text Available Kourtney J Davis,1 Sarah H Landis,2 Yeon-Mok Oh,3 David M Mannino,4 MeiLan K Han,5 Thys van der Molen,6 Zaurbek Aisanov,7 Ana M Menezes,8 Masakazu Ichinose,9 Hana Muellerova11Worldwide Epidemiology, GlaxoSmithKline, Wavre, Belgium; 2Worldwide Epidemiology, GlaxoSmithKline, Uxbridge, UK; 3University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea; 4University of Kentucky College of Public Health, Lexington, KY, USA; 5Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, USA; 6University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; 7Pulmonology Research Institute, Moscow, Russia; 8Federal University of Pelotas, Pelotas, Brazil; 9Tohoku University Graduate School of Medicine, Sendai, JapanAim: Utilizing data from the Continuing to Confront COPD (chronic obstructive pulmonary disease International Physician Survey, this study aimed to describe physicians’ knowledge and application of the GOLD (Global initiative for chronic Obstructive Lung Disease Global Strategy for the Diagnosis, Management and Prevention of COPD diagnosis and treatment recommendations and compare performance between primary care physicians (PCPs and respiratory specialists.Materials and methods: Physicians from 12 countries were sampled from in-country professional databases; 1,307 physicians (PCP to respiratory specialist ratio three to one who regularly consult with COPD, emphysema, or chronic bronchitis patients were interviewed online, by telephone or face to face. Physicians were questioned about COPD risk factors, prognosis, diagnosis, and treatment, including knowledge and application of the GOLD global strategy using patient scenarios.Results: Physicians reported using spirometry routinely (PCPs 82%, respiratory specialists 100%; P<0.001 to diagnose COPD and frequently included validated patient-reported outcome measures (PCPs 67%, respiratory specialists 81%; P<0.001. Respiratory

  19. Til varnar hagfræðinni. Á hagfræðin að skýra kulnun sólar, finna lækningu við krabbameini og skýra uppruna alheimsins?

    Directory of Open Access Journals (Sweden)

    Þórólfur Matthíasson

    2011-06-01

    Full Text Available Það er orðið nokkuð vinsælt tómstundagaman hjá álitsgjöfum og bloggurum hérlendis og erlendis að láta niðrandi ummæli falla um hagfræði og hagfræðinga. Ekki er ástæða, hvorki fyrir fræðigreinina né iðkendur hennar að amast við gagnrýni sé markmið hennar að stuðla að endurbótum og uppbyggingu. Sleggjudómar, órökstuddar fullyrðingar og samsærisbrigsl eru hins vegar ekki til uppbyggingar fallin. Hin opinbera umfjöllun um hagfræði ber með sér að álitsgjafar og bloggarar hafi ólíkar hugmyndir um hvað hagfræði sé. Það er þess vegna rétt að byrja á að skilgreina viðfangsefnið. Orðabókarskilgreiningin er sú að hagfræði sé fræðigrein sem fjallar um framleiðslu, dreifingu og neyslu vöru og þjónustu. Markmið greinarinnar er að skilja á hvaða grundvelli einstaklingar skiptast á vörum og þjónustu. Til að ná markmiðum sínum stunda iðkendur greinarinnar víðtæka söfnun gagna og upplýsinga. Þetta má kalla hina lýsandi hlið hagfræðinnar. Til að skilja þessi gögn og setja þessar upplýsingar í samhengi setja iðkendurnir fram kenningar um atferli og markmið einstaklinga og hópa einstaklinga. Á grundvelli kenninganna eru síðan settar fram tilgátur sem reynt er að styðja eða fella. Skylda vísindamannsins er leggja að minnsta kosti jafn mikið á sig til að fella tilgátu, sem hann hefur sett fram, eins og til að styðja hana. Að þessu leyti eru kröfur til iðkenda í fræðistörfum með öðrum hætti en kröfur til stjórnmálamanna, bloggara eða álitsgjafa.

  20. Statutes of Limitation for Sexual Offenses Against Children Fyrning kynferðisbrota gegn börnum

    Directory of Open Access Journals (Sweden)

    Svala Ísfeld Ólafsdóttir

    2007-12-01

    Full Text Available Abstract in English is unavailable.Hér á eftir er rakinn aðdragandi þeirra breytinga sem gerðar voru á fyrningarreglum almennra hegningarlaga vegna kynferðisbrota gegn börnum síðasta vor með lögum nr. 61/2007. Ein þeirra fól í sér að alvarleg kynferðisbrot gegn börnum fyrnast nú ekki. Frá refsipólitísku og afbrotafræðilegu sjónarmiði er þessi breyting athyglisverð. Í henni felst frávik frá þeirri stefnumörkun löggjafans til langs tíma að fækka ófyrnanlegum brotum og að eingöngu þau brot sem geta varðað ævilöngu fangelsi skuli vera ófyrnanleg. Ekkert þeirra kynferðisbrota sem breytingin tekur til getur varðað svo þungri refsingu. Breytingin átti sér langan aðdraganda, þótt svo mætti virðast af ferli málsins á Alþingi vorið 2007 að hana hafi borið brátt að. Fjöldi frumvarpa sem að þessu snúa hefur verið lagður fram á Alþingi síðari ár og umræður á þeim vettvangi um eðli kynferðisbrota gegn börnum, rannsóknir fagfólks og reynslusögur fórnarlamba kynferðisbrota og lýsingar þeirra á afleiðingum brotanna á lífshlaup sitt, skýra þetta frávik frá meginstefnu löggjafans að verulegu leyti. Ákvörðunin var tekin eftir mikil skoðanaskipti og umræður. Aðdragandinn sýnir að breytingin byggist á sérstöku eðli þessara brota og felur í sér áherslu á alvarlegar og langvarandi afleiðingar þeirra fyrir fórnarlömbin, sem taldar eru vega þyngra en almenn rök að baki fyrningarreglum um réttarstöðu brotamanns, erfiðleika við rannsókn brotanna og sönnun. Á hinn bóginn má vera að vegna þessara vandkvæða feli breytingin fyrst og fremst í sér táknræna viðurkenningu löggjafans á alvarleika brotanna, fremur en að hún eigi eftir að hafa mikla raunhæfa þýðingu.

  1. Whole genome sequencing and analysis of avian influenza virus subtype H9N2 isolated in Tibet province%H9N2亚型禽流感病毒西藏分离株的全基因组遗传进化分析

    Institute of Scientific and Technical Information of China (English)

    索朗斯珠; 邹威; 王灿; 柯尖江; 朱记平; 陈焕春; 金梅林

    2011-01-01

    The present study was conducted to the whole genome sequencing and analysing of three H9N2 avian influenza viruses isolate in Tibet. 8 pairs of the primers were designed based on the sequences of H9N2 avian influenza viruses released in GenBank database,then RT-PCR was performed to gain the 8 genes of the three isolates: A/chiken/ Tibet/Sl/2009,A/Duck/Tibet/S2/2009 and A/Chiken/Tibet/S4/2009,and finally,homology and genetic evolution analysis were performed according to the sequences. The results showed that each gene segment of the isolates contained complete open reading frame. The cleavage site of HA gene was RSSR/G, which is a character of low pathogenic avian influenza virus. The gene homology of the 3 isolates was 98%-99% indicating that these three viruses might be from the same source. The HA,NA and NS genes of the viruses displayed the closest genetic relationship with the virus A/Duck/HongKong/Y280/97,which belonged the Euro-Asia A/Chiken/Beijing/1/94 branch. However,the M,NP,PA,PB1 and PB2 genes located with another Euro-Asia isolate A/Quail/HongKong/Gl/9. This demostrated that the gene segments of the three viruses isolated in Tibet came from different ancestors, which might be the natural gene rearrangment products when the host were infected by different subtypes of avian influenza virus.%根据GenBank登陆的H9N2亚型AIV全基因组序列,设计了8对引物,运用RT-PCR的方法获取了3株H9N2亚型AIV西藏分离株A/Chiken/Tibet/S1/2009、A/Duck/Tibet/S2/2009和A/Chiken/Tibet/S4/2009的8个基因序列,并对所得序列进行同源性及遗传进化分析.结果显示,分离毒株的各基因片段均有完整的开放阅读框,HA基因裂解位点处均为RSSR/G,符合低致病性禽流感的特征;3株西藏分离毒株之间同源性为98%~99%,可能起源于同一种系;各分离毒的HA、NS和NA基因与欧亚分支A/Chiken/Beijing/1/94分支中的A/Duck/HongKong/Y280/97遗传距离最近,而M、NP、PA、PB1和PB2基因与欧亚分

  2. Recording of hospitalizations for acute exacerbations of COPD in UK electronic health care records

    Directory of Open Access Journals (Sweden)

    Rothnie KJ

    2016-11-01

    Full Text Available Kieran J Rothnie,1,2 Hana Müllerová,3 Sara L Thomas,2 Joht S Chandan,4 Liam Smeeth,2 John R Hurst,5 Kourtney Davis,3 Jennifer K Quint1,2 1Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, UK; 2Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK; 3Respiratory Epidemiology, GlaxoSmithKline R&D, Uxbridge, London; 4Medical School, 5UCL Respiratory, University College London, London, UK Background: Accurate identification of hospitalizations for acute exacerbations of chronic obstructive pulmonary disease (AECOPD within electronic health care records is important for research, public health, and to inform health care utilization and service provision. We aimed to develop a strategy to identify hospitalizations for AECOPD in secondary care data and to investigate the validity of strategies to identify hospitalizations for AECOPD in primary care data. Methods: We identified patients with chronic obstructive pulmonary disease (COPD in the Clinical Practice Research Datalink (CPRD with linked Hospital Episodes Statistics (HES data. We used discharge summaries for recent hospitalizations for AECOPD to develop a strategy to identify the recording of hospitalizations for AECOPD in HES. We then used the HES strategy as a reference standard to investigate the positive predictive value (PPV and sensitivity of strategies for identifying AECOPD using general practice CPRD data. We tested two strategies: 1 codes for hospitalization for AECOPD and 2 a code for AECOPD other than hospitalization on the same day as a code for hospitalization due to unspecified reason. Results: In total, 27,182 patients with COPD were included. Our strategy to identify hospitalizations for AECOPD in HES had a sensitivity of 87.5%. When compared with HES, using a code suggesting hospitalization for AECOPD in CPRD resulted in a PPV of 50.2% (95

  3. The position of the political parties before the general election in 2007 from a marketing perspective Markaðsfræðilegt sjónarhorn á stöðu stjórnmálaflokka fyrir alþingiskosningarnar 2007

    Directory of Open Access Journals (Sweden)

    Þórhallur Guðlaugsson

    2008-06-01

    Full Text Available Abstract in English is unavailable.Viðfangsefni greinarinnar er mat á staðfærslu stjórnmálaflokka og hvernig ímynd og staðfærsla tengjast faglegu markaðsstarfi, samkeppnishæfni og árangri. Fjallað er um niðurstöður rannsóknar þar sem lagt er mat á staðfærslu stjórnmálaflokka hjá ungu fólki og skoðað með hvaða hætti hún endurspeglar árangur í kosningum. Í þessu sambandi eiga stjórnmálaflokkar í nokkrum vanda. Stjórnmálaflokkar eru ekki fyrirtæki þar sem hægt er að gefa út tiltekna línu hvað samskipti og skilaboð varðar. Vissulega reyna menn þó að stilla saman strengi sína, sérstaklega í kosningabaráttunni. Þar virðast flestir flokkar leggja áherslu á loforð, þ.e. kjósi menn flokkinn þá muni þetta eða hitt gerast eða breytast eftir kosningar. Fólk virðist þó ekki gera ráð fyrir því að stjórnmálamenn standi við gefin loforð og virðast margir bera meira traust til einstaklinga almennt en stjórnmálamanna. Kjósendur hafa iðulega óljósa mynd af því fyrir hvað tiltekinn stjórnmálaflokkur stendur en ýmislegt bendir til þess að tengsl séu á milli staðfærslu og árangurs í kosningum. Þrír stjórnmálaflokkar virðast hafa skýra og afgerandi stöðu hjá ungu fólki, Sjálfstæðisflokkurinn, Vinstrihreyfingin grænt framboð og Framsóknarflokkurinn. Tveir þeirra tengjast jákvæðum eiginleikum en einn neikvæðum gildum. Tveir stjórnmálaflokkar virðast hafa óljósa stöðu í huga ungra kjósenda, Samfylkingin og Frjálslyndi flokkurinn. Hafa þarf í huga að staðfærsla verður ekki mæld í eitt skipti fyrir öll og mikilvægt að mæla hana reglulega ef niðurstöðurnar eiga að nýtast í faglegu markaðsstarfi flokkanna.

  4. 聚乙烯醇/壳聚糖互穿聚合物海绵的制备及应用探索%Preparation and Application of Poly(Vinyl Alcohol)-Chitosan Interpenetrating Polymer Sponge

    Institute of Scientific and Technical Information of China (English)

    何谷; 陈煜; 张明明; 王东旭; 丛堃; 范海波; 周芳集

    2011-01-01

    Poly(vinyl alcohol)-chitosan interpenetrating polymer network was synthesized in acetic acid solution with polyvinyl alcohol and chitosan as raw materials, glutaraldehyde as crosslinker, sodium hyaluronate and gelatin as additives. After freezing dry, the interpenetrating polymer sponge was prepared. The molecular structure of the sponge was confirmed by FT-IR, and the surface morphologies were examined by SEM. The factors influencing the swelling properties of the sponge were studied. It is found that the optimum reaction condition is that mPVA-1788: mCTS= 6:1, mSodium hyaluronate: mCTS = 0.4:1, mgtutaraldehyde: mCTS = 0.283:1,mOEL: mCTS = 1:1, CPVA-788 = 0.97 mol/L. The pores superabsorbent sponge prepared through these conditions can absorb over 25 g/g distilled water. The hemostatic properties of the sponge were studied through the hemostatic models of ear artery of rabbits. The results show that the hemostatic ratio is 100% and the using of the sponge reduces the hemostatic time and the loss of blood. All of these show that the hemostatic properties of the sponge are ideal.%以聚乙烯醇和壳聚糖为原料,戊二醛为交联剂,透明质酸钠和明胶为添加剂,在醋酸溶液中合成了聚乙烯醇-壳聚糖互穿聚合物,并采用冷冻诱导相分离的方法制备了具有多孔结构的海绵,用红外光谱(FT-IR)和扫描电镜(SEM)方法对其结构进行了表征,研究了影响海绵溶胀性能的多种因素.实验结果表明,当m(PVA-1788):m(CTS)=6:1、m(HANa):m(CTS)=0.4:1、m(戊二醛):m(CTS)=0.283:1、m(GEL):m(CTS)=1:1、C(PVA-1788)=0.97 mol/L时,可制得吸水倍率约为25 g/g成型性能较好的多孔高吸水性海绵.用此海绵对兔耳创面的出血进行止血实验测试,结果表明海绵的止血率为100%,且止血时间缩短、总失血量减小,达到了快速有效的止血效果.

  5. Alzheimer's disease and its treatment costs: case study in the Czech Republic

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    Mohelska H

    2015-09-01

    Full Text Available Hana Mohelska,1 Petra Maresova,2 Martin Valis,3 Kamil Kuca4,5 1Department of Management, 2Department of Economy, Faculty of Informatics and Management, University of Hradec Králové, 3Department of Neurology, Charles University in Prague, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, 4Biomedical Research Centrum, University Hospital Hradec Králové, 5Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Králové, Hradec Králové, Czech Republic Abstract: This paper deals with the analysis of the costs, applied, for example, when treating specific diseases – an important aid in prioritizing the process of resource allocation. In our review, the specific disease is dementia caused by Alzheimer’s disease. This paper aims to provide more information on the partial costs per patient that are calculated according to the aggregated data from publicly available sources as well as from the results of authors’ own investigation. The University Hospital in Hradec Králové and the General Health Insurance Company of the Czech Republic participated in this research. The elementary research objective was to compare the costs per patient diagnosed early onset, to those of the patient diagnosed later. The Czech Republic lacks information regarding dementia. Therefore, these issues require attention. The methods used in this paper included time series analyses, methods of direct questioning, interviews with experts, and analyses of medical documentation. These methods were combined to exploit their particular advantages and to ensure the issues discussed, were covered. The investigation showed that the underpinning of patients with Alzheimer’s disease at early onset is advantageous from an economic perspective, because the cost of outpatient care is much lower compared with that of inpatient care. The international comparisons of the volume of care provided should be

  6. Relationship between polymorphism of COMT gene and clinical outcomes of depression in patients with type 2 diabetes treated with paroxetine%儿茶酚氧位甲基转移酶基因功能多态性对帕罗西汀治疗2型糖尿病伴抑郁患者疗效的相关性

    Institute of Scientific and Technical Information of China (English)

    刘广军; 成金罗; 曹音

    2012-01-01

    目的:探讨儿茶酚氧位甲基转移酶(COMT)基因功能多态性对帕罗西汀治疗2型糖尿病合并抑郁焦虑患者的疗效的影响.方法:对52例血糖控制不理想的2型糖尿病合并抑郁焦虑患者,治疗前抽取外周静脉血,提取DNA,用PCI技术检测研究对象的基因型,分成Val/Val、Val/Met和Met/Met 3组,在常规降糖治疗基础上加用帕罗西汀每晨一次,每次20 mg,疗程4周,观察治疗前、后汉密尔顿抑郁量表(HAMD)、汉密顿焦虑量表(HAMA)分数、餐后2h血糖(2hPBG)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、帕罗西汀血药浓度的改变.结果:治疗后不同基因组患者抑郁情绪有改善,HAMD、HAMA、2hPBG、FBG、HbA1c、血药浓度与治疗前比较均有显著性差异(P<0.01),但4周后3基因组间差异并无显著性(P>0.05).结论:对2型糖尿病合并抑郁焦虑患者,加用帕罗西汀治疗能有效改善抑郁症状及更好地控制血糖,COMT基因功能多态性与帕罗西汀疗效差异可能并不相关.%OBJECTIVE To investigate the relationship between the polymorphism of COMT gene and clinical outcomes of depression in patients with type 2 diabetes treated with paroxetine. METHODS Fifty-two type 2 diabetes mellitus patients accompanied with depression were treated with paroxetine(20 mg, qd) for 4 weeks. DNAs of peripheral blood leukocytes from 52 patients with type 2 diabetes were obtained before therapy and were analyzed for genotypes by PCR-RFLP method. They were divided into three groups of Val/Val, Val/Met and Met/Met. Hamilton depression scale(HAMD), Hamilton anxiety scale (HAMA). 2hPGB, FBG, HbAlc levels and plasma concentration were obtained to monitor glycemic control. RESULTS Paroxetine significantly improved the symptoms of depression and anxiety in type 2 diabetes mellitus with depression. At the end of the 4th week, the levels of 2hPBG, FBG, HbAlc and scores of both the HAMD and HANA decreased compared with pre-treat-ment (P<0. 01). But

  7. 甲型H7N9流感病毒血凝素和神经氨酸酶的进化及抗原位点变异分析%An analysis on HA, NA gene/protein evolution and the variability of antigenicity sites of influenza A (H7N9) virus

    Institute of Scientific and Technical Information of China (English)

    李虎; 胡鹏

    2013-01-01

    Objective To explore the hemagglutinin (HA),neuraminidase (NA) gene/protein evolution and the variability of antigenicity sites of influenza A (H7N9) virus.Methods The sequences of HA,NA gene and amino acid (AA) were downloaded from National Center for Biotechnology Information (NCBI) and the Global Initiative on Sharing All Influenza Data (GISAID) database.The bioinformatic software programs of Clustal-W,MEGA 5.0,NetNGlyc 1.0 Server and DNAMAN were employed to analyze the variations and predict the possible antigenicity sites.Results A total of 26 HA gene and AA and 24 NA gene and AA sequences were analyzed.HA,NA gene and AA sequence of H7N9 virus were conservative in America but not in Eurasian area.The HA and NA gene evolutions could be divided into 2 general systems:Eurasian and America.Only one basic AA R (Arg) was close to HA cleavage sites of H7N9 virus.Regional differences existed between HA protein cleavage and NA protein glycosylation sites.And the HA glycosylation sites were conservative.Several antigenicity sites of HA and NA protein changed in Eurasian area and America.In 7 cases,novel H7N9 evolved virus isolated from China were one branch of Eurasian area.Five AAs were deleted in stalk region of NA residues 69 to 73.HA protein cleavage and glycosylation sites did not carry the variant.However,several antigenicity sites of HA and NA protein changed compared with other virus strains.Conclusions Regional differences exist in HA and NA gene evolution of H7N9 virus.The deletion of 5 AAs in stalk and the variation of several antigenicity sites of HA and NA protein may lead to an outbreak of H7N9 virus in humans.%目的 分析甲型H7 N9流感病毒的血凝素(HA)、神经氨酸酶(NA)进化及其抗原位点变异.方法 从美国国立生物技术信息中心(NCBI)和全球共享禽流感数据倡议组织(GISAID)数据库检索并下载从建库到2013年4月13日的H7N9病毒HA、NA的基因和氨基酸序列.应用Clustal-W、MEGA 5.0、NetNGlyc 1

  8. Association study of PRODH gene variant rs385440 with schizophrenia in Zhuang and Han nationality of Guangxi%广西壮族、汉族精神分裂症与PRODH基因rs385440多态性的关联研究

    Institute of Scientific and Technical Information of China (English)

    苏莉; 韦波; 陈强; 冯启明; 潘润德; 周阳; 龙建雄

    2012-01-01

    目的 探讨PRODH基因的rs385440与广西壮族、汉族精神分裂症易感性及其临床症状严重程度之间的关联性,以进一步探明壮、汉族精神分裂症的遗传机制.方法 本研究采用病例对照研究方法,以ICD-10为诊断标准,纳入精神分裂症患者282例(壮族94例、汉族188例),健康对照282例(壮族94例、汉族188例).使用TaqMan MGB荧光定量实时PCR实验方法对PRODH基因的rs385440进行基因分型.使用PANSS对246例精神分裂症患者(壮族83例、汉族163例)的临床精神病性症状进行评定.使用SPSS13.0 for windows软件进行统计分析.结果 分别在壮族样本、汉族样本以及两个民族的合并样本中,rs385440不同基因型频率、不同等位基因频率在病例组和对照组之间的分布差异均无统计学意义(P>0.05).在壮族精神分裂症病例中,A等位基因携带者的N4(被动或淡漠社交)条目分[(3.28 ±1.34)分]显著高于G等位基因携带者[(2.40±1.36)分],A等位基因携带者的G12(判断和自知力缺乏)条目为[(4.92±1.55)分]也显著高于G等位基因携带者[(4.12±1.85)分],均差异有统计学意义(P<0.05).结论 PRODH基因的rs385440与壮族、汉族精神分裂症的易感性都不相关联,但rs385440与壮族精神分裂症的“被动或淡漠社交”、“判断和自知力缺乏”症状严重程度相关联.%Objective To test the the association between PRODH gene variant rs385440 and the susceptibility to schizophrenia and the severity of schizophrenia in Guangxi Zhuang and Han population,further exploring the genetic mechanisms of schizophrenia in Guangxi Zhuang and Han population.Methods The schizophrenia patients were diagnosed according to ICD-10 criteria in this study.The subjects in the association analysis were 282 unrelated schizophrenia patients(94 Zhuang and 188 Han) and 282 healthy controls (94 Zhuang and 188 Han).A quantitative real-time PCR TaqMan MGB experimental method was carried out to

  9. Image and marketing of municipalities Ímynd og markaðsstarf sveitarfélaga

    Directory of Open Access Journals (Sweden)

    Þórhallur Guðlaugsson

    2009-12-01

    ður því ekki mæld í eitt skipti fyrir öll heldur þarf að mæla hana reglulega.

  10. The competitiveness of the Icelandic film industry Samkeppnishæfni íslenska kvikmyndaiðnaðarins

    Directory of Open Access Journals (Sweden)

    Konráð Pálmason

    2011-06-01

    kvikmyndasjóða mun leiða til þess að færri kvikmyndaverk (t.d. kvikmyndir og sjónvarpsþættir verði framleidd og starfsfólki fækki í greininni. Þetta mun draga umtalsvert úr vexti og hamla framþróun atvinnugreinarinnar. Heildartekjur kvikmyndaiðnaðarins af innlendum og erlendum kvikmyndaverkefnum sl. áratug eru áætlaðar um 9 milljarðar króna. Tilgangur rannsóknar höfunda er að greina samkeppnishæfni kvikmyndaiðnaðarins á Íslandi og að hve miklu leyti hún er byggð á klasasamstarfi. Aðferðafræði rannsóknarinnar fólst í eigindlegum opnum viðtölum við lykilstjórnendur í atvinnugreininni. Kvikmyndaiðnaðurinn er að hluta til samkeppnishæfur. Styrkleiki hans er m.a. hversu einfalt og skilvirkt endurgreiðslukerfi ríkisins til kvikmyndaverkefna er í framkvæmd. Aðrir styrkleikar eru stórbrotin náttúra og auðvelt aðgengi að ólíkum tökustöðum. Góðir innviðir, lítið skrifræði og vinnusamt og hæft vinnuafl hafa jákvæð áhrif á samkeppnishæfni atvinnugreinarinnar. Veikleikarnir eru hins vegar að lítil klasamyndun hefur átt sér stað innan greinarinnar, ásamt því að lítil vitund er um samlegðaráhrif sem geta eflt greinina. Heimamarkaðurinn er of lítill og miklar sveiflur í eftirspurn hafa torveldað vöxt greinarinnar. Endurgreiðsluhlutfall ríkisins þarf að hækka úr 20% í 25-30% til að atvinnugreinin geti talist fyllilega samkeppnishæf alþjóðlega. Almenn efnahagsskilyrði hafa dregið úr samkeppnishæfni atvinnugreinarinnar, s.s. óstöðugur gjaldmiðill og gjaldeyrishöft þó lægra gengi hafi styrkt hana. Niðurstöður rannsóknarinnar hafa hagnýtt gildi bæði fyrir atvinnugreinina og stjórnvöld.

  11. Ambitious Icelanders: The Background and Beginning of Icelandic International Development Stórhuga Íslendingar: Forsaga og upphaf íslenskrar þróunarsamvinnu

    Directory of Open Access Journals (Sweden)

    Kristín Loftsdóttir

    2011-12-01

    æri sem hefðu yfir að ráða tæknilegri sérfræðiþekkingu sem færa myndi samfélög frá einu stigi þróunar yfir á annað. Söfnun upplýsinga til að staðsetja samfélög á þróunarskala náði til smæstu þátta mannlegs samfélags og gaf hugmyndinni um þróunarlönd áþreifanlegt inntak. Í greinin er upphaf íslenskrar þróunarsamvinnu skoðað og leitast við að setja hana í samhengi við alþjóðlegar hugmyndir um þróunarsamvinnu. Umfjöllunin hefst á umræðu um mótun alþjóðlegrar þróunarsamvinnu út í hinum stóra heimi og hugmyndafræðilegt forræði hennar. Síðan er gerð grein fyrir því hvernig viðfangsefnið "þróunarlönd" birtist í íslensku samhengi á ákveðnu tímabili og hvernig má sjá áhrif frá alþjóðlegum straumum, sem endurspeglast meðal annars í auknum þrýstingi á stjórnvöld að hefja þróunarsamvinnu. Fyrstu skref stofnunarinnar Aðstoð Íslands við þróunarlöndin sem sett var á fót 1971 endurspegla þó lítinn áhuga stjórnvalda á þróunarsamvinnu. Greinin varpar einnig ljósi á áhrif þessa alþjóðlegu straumar á Íslandi og hvernig þeir virkjuðu hluta þjóðarinnar í ákalli um mikilvægi þess að íslenska þjóðin sinnti þróunarsamvinnu.

  12. Úvodník

    Directory of Open Access Journals (Sweden)

    Jana Dlouhá

    2013-10-01

    ředminulého čísla Envigogiky pouští také Peter Sabo a Ľudmila Sabová – vymezují se vůči zatvrzelému „popírači kultury“ profesoru Šmajsovi, a stejně jako Jiří Nečas vidí cestu v navázání na její nejlepší tradice. Text publikujeme včetně recenzí, které přinášejí nové pohledy na tento problém a odkazy do literatury. Lehce se dotkneme i uměleckého uchopení přírody: jak funguje „umění v krajině“ popisuje v recenzi nově vydané knížky o land artu Hana Kolářová. A Jiří Olšovský se pokouší sdělit, jak lze do vztahu k přírodě vstoupit i dnes, ve věku ovládaném technikou.Do jiného soudku patří texty, které se zabývají rolí vědy a politiky při zařizování kvalitního, dlouhodobě udržitelného života. Vtipně a přitom s erudicí psaný text Františka Kožíška a Petra Pumanna se věnuje úskalím, která může potkat vědec, pokud chce svědomitě sdělit své výsledky veřejnosti. Autoři popisují, jak se postupně podstata jejich sdělení „ztratila v překladu“ do stručných mediálních zpráv a především jejich titulků – uvažují, jak by se dalo zkreslením tohoto druhu vyhnout, aniž by se věda uzavřela sama do sebe. I v tomto čísle se věnujeme možnostem hodnocení EV, tentokrát ve velmi komplexním a zasvěceném pohledu na environmentální gramotnost z dílny Petra Daniše, který nám podal zprávu (nejen o připravovaném výzkumu PISA v roce 2015. Osvětu veřejnosti v ochraně přírody a význam zapojení různých společenských skupin mají na mysli Peter Repka a Milada Švecová, když představují způsob, jak efektivně analyzovat management chráněných území. Jana Laciná a Vlastimil Kostkan se pokoušejí zprostředkovat široké veřejnosti nejnovější poznatky z přírodovědných i společensko-vědních oborů souvisejících se životním prostředím, a podávají nám o tom zprávu. Mozaiku doplňuje pohled do blízké minulosti a o