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Sample records for hamlet king lear

  1. The Genius of Shakespeare’s “Plagiarisms”. Case Studies: Hamlet, Othello, King Lear and Macbeth

    Directory of Open Access Journals (Sweden)

    Cuțitaru Codrin Liviu

    2017-06-01

    Full Text Available This paper aims at exploring the cultural ambiguity which William Shakespeare remarkably extracts from the sources of his major plays, turning it, eventually, into an essential instrument of the tragic and the tragedy. What in normal/modern circumstances would easily count as “plagiarism”, becomes here, paradoxically, a token of artistic genius and brilliant creation. Our examples will be from the four outstanding tragedies—Hamlet, Othello, King Lear and Macbeth. The sources selected by our research will be Saxo Grammaticus’s Histoires tragiques, Cinthio’s Un Capitano Moro, the Celtic legend Leir of Britain and, obviously, Holinshed’s Chronicles. We shall try to demonstrate that the so-called cultural ambiguity adopts various forms in Shakespeare’s plays, going from the clash of civilisations (Hamlet and Othello to the crisis of identity (Lear and Macbeth.

  2. Hamlet, Macbeth, Othello and King Lear in the English Teaching at School: a methodological approach - doi: 10.4025/actascieduc.v34i2.15070

    Directory of Open Access Journals (Sweden)

    Valdomiro Polidório

    2012-11-01

    Full Text Available In this article we will talk about the relevance of dramatic texts in schools. Therefore we will approach the tragedies Hamlet, Macbeth, Otelo e King Lear de William Shakespeare and how teachers can explore them as a help in the teaching of languages without forgetting that they are dramatic and literary texts. When we refer to languages, we want to say any language, because Shakespearean texts are ageless, may have many meanings and deal with human nature. The theatre is in our lives and in this case it is relevant to quote William Shakespeare himself that said that “life is a stage and we are actors”. Starting from this, we will consider the best ways of using the tragedies Hamlet, Macbeth, Otelo e King Lear in the classroom.  

  3. King Lear Reveals the Tragic Pattern of Shakespeare

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    Salim Eflih Al-Ibia

    2017-04-01

    Full Text Available Rather than focusing on the obvious traditions of evaluating Shakespearean tragic heroes, this paper presents a groundbreaking approach to unfold the pattern William Shakespeare follows as he designed his unique characters. This pattern applies to most, if not all, Shakespearean tragic heroes. I argue that Shakespeare himself reveals a great portion of this pattern on the tongue of Lear as the latter disowns Goneril and Regan promising to have “such revenges on [them] both” in King Lear. Lear’s threats bestow four unique aspects that apply not only to his character but they also apply to Shakespearean tragic heroes. Lear’s speech tells us that he is determined to have an awful type of revenge on his daughters. However, the very same speech tells us that he seems uncertain about the method through which he should carry out this revenge. Lear does not express any type of remorse as he pursues his vengeful plans nor should he aim at amnesty. He also admits his own madness as he closes his revealing speech. This research develops these facts about Lear to unfold the unique pattern Shakespeare follows as he portrayed his major tragic figures. This pattern is examined, described and analyzed in King Lear, Othello, and Hamlet. We will find out that the pattern suggested in this study helps us better understand Shakespeare’s tragedies and enables us to provide better explanations for some controversial scenes in the tragedies discussed.

  4. Re-shaping King Lear: Space, Place, Costume, and Genre

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    Hattaway Michael

    2017-06-01

    Full Text Available Performance studies must enjoy parity of esteem with critical studies because they remind us of the plurality of “readings” that are generated by a Shakespearean text. Shakespeare seems to have apprehended this when, in Othello, he used a nonce-word, “denotement”, which applies to Othello’s reading of his wife in his mind’s eye. I examine other sequences in which we watch a character “reading” on-stage or imagined action, in Hamlet, Titus Andronicus, Cymbeline, Richard II, and Troilus and Cressida. In Hamlet this involves re-reading as well as generic displacement, which, I argue, is a way of rendering inwardness. As I test case, I analyse a production of King Lear by Shakespeare’s Globe, on a fairground stage, in which the king reshaped himself, became a folkloric figure, like a figure in Nashe’s Summer’s Last Will and Testament. The play itself was thus, indecorously, reshaped as “The Tale of King Lear”. “Dramatic truth”, therefore, in no way depends upon theatrical “realism”.

  5. Blindness and Insight in King Lear

    Institute of Scientific and Technical Information of China (English)

    岳元玉

    2008-01-01

    This paper intends to explore how William Shakespeare illustrates the theme of blindness and insight in his great tragedy "King Lear".Four characters’ deeds and their fate are used as a case study to examine what blindness is,what insight is,and the relationship between the two.The writer finds that by depicting the characters’ deeds and their fate in a double plot,Shakespeare renders the folly of blindness,the transition from blindness to insight,and the use of reason and thought to understand the truth.

  6. Shame, recognition and love in Shakespeare’s 'King Lear'

    DEFF Research Database (Denmark)

    Montes Sanchez, Alba

    2014-01-01

    In this paper, I explore the experience of shame and its connections to recognition and love as manifested in Shakespeare’s King Lear. My main focus in this paper is the ethical relevance of shame. I start from Sartre’s account of shame in Being and Nothingness, and I consider Webber’s attempt...

  7. LEAR

    International Nuclear Information System (INIS)

    Lefevre, P.

    1984-01-01

    In general LEAR provides a precise experimental tool which: opens the domain of low energy quark dynamics (chemistry of quarks by carrying experiments connected to baryonium, gluonium, etc..), using nuclear targets it allows to tackle the nuclear physics aspects in a completely new fashion, permits many exciting applications to future options due to the further improvements on statistical precision and energy resolution (Δp/p): internal targets, H - anti p co-rotating beams (protonium formation in flight), panti p collider and ultra low energy domain (down to 20 MeV/c.). (orig./HSI)

  8. Oedipus the King and Hamlet: A Descent to the Fathers

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    Chiara Lombardi

    2017-11-01

    Full Text Available Sulla base delle letture freudiane e di alcune ipotesi circa la circolazione del teatro greco nell’Europa e nell’Inghilterra del Cinquecento e sulla possibile ricezione shakespeariana, questo contributo propone alcune tangenze tra Sofocle e Shakespeare. L’analisi si concentra non tanto su una figura del mito, quanto sull’intreccio di più vettori e di più personaggi ad esso attinti: il ricorso a Edipo, ad esempio, si intravvede non soltanto nel palinsesto di Hamlet – come è stato ampiamente e variamente dimostrato –  ma anche dietro al Lear, mentre Elettra diventa un ulteriore, meno indagato, punto di riferimento della costruzione psicologica e drammaturgica di Amleto.  Si vorrebbe così dimostrare come Shakespeare ricorra al modello tragico greco e, nello specifico, di Sofocle, nel momento in cui l’intreccio della tragedia, nei suoi momenti di maggiore tensione (e incertezza conoscitiva, richiede una sorta di interrogazione e di mobilitazione di archetipi e, in particolare, di quelli collegati alle figure dei padri e al loro rapporto con il potere.

  9. Escaping from allegories:cat’s eye and King Lear Escaping from allegories:cat’s eye and King Lear

    Directory of Open Access Journals (Sweden)

    Caroline Cakebread

    2008-04-01

    Full Text Available In her 1972 study of Canadian literature, aptly titled Survival, Margaret Atwood uses the symbol of the mirror to describe the difficulty faced by Canadian writers and artists, struggling to assert their voices in a country trying to define itself against a colonial past.Here, she sees Canada as squeezed between the overwhelming, colonizing powers of Great Britain on one side, and The United States on the other. In her view, a piece of art becomes a mirror. As she writes: If a country or a culture lacks such mirrors it has no way of knowing what it looks like; it must travel blind. If, as has long been the case in [Canada], the viewer is given a mirror that reflects not him but someone else, and told at the same time that the reflection he sees is himself, he will get a very distorted idea of what he is really like. He will also get a distorted idea of what other people are like: it’s hard to find out who anyone else is until you have found out who you are. (15-16 With its roots in Lacanian psychoanalysis, the mirror Atwood describes provides an unreliable reflection for burgeoning artists inCanada: up against the powerful countries that surround them she sees a major identity crisis. Sixteen years later, her 1988 novel, Cat’s Eye, treads similar ground, tracking as it does the passage of its protagonist—painter, Elaine Risley—through childhood in mid-century Canada to her development as an established artist in the 1980s. It is into this narrative that Atwood places extensive references to Shakespeare’s tragedy, King Lear—a play that deals with the notion of identity. Here, Lear’s question, “Who is it that can tell me who I am?” becomes Elaine’s, as she ventures back to Toronto to attend a retrospective of her work at a women’s art gallery named “Sub-Versions.” In her 1972 study of Canadian literature, aptly titled Survival, Margaret Atwood uses the symbol of the mirror to describe the difficulty faced

  10. "The Lion King" and "Hamlet": A Homecoming for the Exiled Child.

    Science.gov (United States)

    Gavin, Rosemarie

    1996-01-01

    Explains how the movie "The Lion King" may be used to elucidate Shakespeare's "Hamlet," a play about a prince who does not always seem heroic to modern audiences. Gives specific points of comparison between the two works concerning heroes, characters, conflicts, themes, ending scenes, and archetypal patterns. (TB)

  11. Once a Villain Always a Villain: Edmund’s “Reformation” in King Lear, 5.3.241-42

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    Sadowski, Piotr

    2015-06-01

    Full Text Available The article examines possible motives behind the alleged change of heart shown by Edmund at the end of King Lear when, defeated by his brother Edgar, he decides to revoke his former order to execute Lear and Cordelia. Edmund’s decision has been almost unanimously interpreted by critics as a sign of genuine remorse and repentance in the face of death. However, I argue that far from denoting any moral reformation, Edmund’s delayed decision to call off the execution is coldly calculated in self-interest, both to play for time and to mollify his captors, Albany and Edgar. Interpreting Edmund’s show of pity as feigned rather than genuine helps preserve both the dramatic consistency of the scene, and the psychological unity of Shakespeare’s stage villain.

  12. “And Thou, all-Shaking Thunder…”A Theological Notation to Lines 1–38 of King Lear, Act III, Scene II

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    William C. Hackett

    2017-05-01

    Full Text Available In the dramas of Shakespeare, the madman and the fool speak in prose; wisdom and sanity are properly poeticised. King Lear is no exception: I go some way in providing a theological notation to a crucial moment of Lear’s descent into madness, the fracturing of his blank verse into prose. Is the storm on the heath a representation of the turmoil of his mind? Or is it a theophany, the manifestation of divine displeasure at human foolishness? Finding between the verse and the prose the theological tradition of Christianity will allow us to negotiate this question and to understand a little more clearly the peculiar wisdom of poetry for Christianity.

  13. Hamlet's Transformation.

    Science.gov (United States)

    Usher, P. D.

    1997-12-01

    William Shakespeare's Hamlet has much evidence to suggest that the Bard was aware of the cosmological models of his time, specifically the geocentric bounded Ptolemaic and Tychonic models, and the infinite Diggesian. Moreover, Shakespeare describes how the Ptolemaic model is to be transformed to the Diggesian. Hamlet's "transformation" is the reason that Claudius, who personifies the Ptolemaic model, summons Rosencrantz and Guildenstern, who personify the Tychonic. Pantometria, written by Leonard Digges and his son Thomas in 1571, contains the first technical use of the word "transformation." At age thirty, Thomas Digges went on to propose his Perfit Description, as alluded to in Act Five where Hamlet's age is given as thirty. In Act Five as well, the words "bore" and "arms" refer to Thomas' vocation as muster-master and his scientific interest in ballistics. England's leading astronomer was also the father of the poet whose encomium introduced the First Folio of 1623. His oldest child Dudley became a member of the Virginia Company and facilitated the writing of The Tempest. Taken as a whole, such manifold connections to Thomas Digges support Hotson's contention that Shakespeare knew the Digges family. Rosencrantz and Guildenstern in Hamlet bear Danish names because they personify the Danish model, while the king's name is latinized like that of Claudius Ptolemaeus. The reason Shakespeare anglicized "Amleth" to "Hamlet" was because he saw a parallel between Book Three of Saxo Grammaticus and the eventual triumph of the Diggesian model. But Shakespeare eschewed Book Four, creating this particular ending from an infinity of other possibilities because it "suited his purpose," viz. to celebrate the concept of a boundless universe of stars like the Sun.

  14. Astronomy and Shakespeare's Hamlet.

    Science.gov (United States)

    Usher, P. D.

    1996-05-01

    Payne-Gaposchkin and others have suggested that Hamlet shows evidence of the Bard's awareness of the astronomical revolutions of the sixteenth century. I summarize major arguments and note that the play's themes recur in modern astronomy teaching and research: (1) The play amounts to a redefinition of universal order and humankind's position in it. (2) There is interplay between appearance and reality. Such a contrast is commonplace wherever superficial celestial appearances obscure underlying physical realities, the nature of which emerge as the tale unfolds. (3) The outermost sphere of the Ptolemaic and Copernican models seems to encase humanity, who are liberated by the reality of Digges' model and the implications advanced by Bruno. Similarly the oppressiveness of the castle interior is relieved by the observing platform which enables the heavens to be viewed in their true light. (4) Hamlet could be bounded in a nut-shell and count himself a king of infinite space, were it not that he has bad dreams. These concern the subversiveness of the new doctrine, for Hamlet refers to the infinite universe only hypothetically and in the presence of Rosencrantz and Guildenstern, who are named for relatives of the Danish astronomer Brahe. (5) Hamlet, and Brahe and Bruno, have connections to the university at Wittenberg, as does the Copernican champion Rheticus. (6) Ways are needed to reveal both the truths of nature, and the true nature of Danish royalty. Those unaccustomed to science think that there is madness in Hamlet's method. In particular, `doubt' is advanced as a methodological principle of inquiry. (7) The impression of normalcy and propriety in the upper reaches of society is like the false impression of an encapsulating universe. In Hamlet this duality is dramatized tragically, whereas in King John (cf. BAAS 27, 1325, 1995) it is not; for by 1601 when the writing of Hamlet was probably completed, Shakespeare would have known of the martyrdom of Bruno the previous

  15. Golden Jubilee photos: LEAR

    CERN Multimedia

    2004-01-01

    Extraction lines that carried the antiprotons from LEAR to the experiments. Beam-splitters and a multitude of beam-lines allowed several users to be supplied simultaneously. Particle physicists don't always need ever more powerful accelerators to study interesting physics. LEAR, the Low Energy Antiproton Ring, was designed to help explore the properties of antimatter, with the annihilation of protons and antiprotons becoming the main theme. LEAR was commissioned in 1983 and contributed to more than 30 experiments with great success. LEAR took part in the discovery of a 'glueball', a particle composed entirely of gluons, the carriers of the strong nuclear force. LEAR also observed that neutral kaons and antikaons decay at a slightly different rate, offering physicists another insight into the mystery about why matter prevails over antimatter in the Universe. Uniquely, LEAR combined both the electron and stochastic beam cooling techniques, used to control and refine the beams. It also pioneered a technique usin...

  16. Thinking cLEARly

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    The smallest ring at CERN is also one of its big successes. The 80 metre LEAR Low Energy Antiproton Ring which came into action in 1982 has provided invaluable research material for several hundred physicists. Whilst the initial programme at LEAR, concentrating on annihilation, search for narrow states etc., is now complete, attention is turning to a second generation of experiments with a slightly shifted emphasis

  17. Thinking cLEARly

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1987-12-15

    The smallest ring at CERN is also one of its big successes. The 80 metre LEAR Low Energy Antiproton Ring which came into action in 1982 has provided invaluable research material for several hundred physicists. Whilst the initial programme at LEAR, concentrating on annihilation, search for narrow states etc., is now complete, attention is turning to a second generation of experiments with a slightly shifted emphasis.

  18. LEAR's physics legacy

    CERN Multimedia

    Philippe Bloch

    2012-01-01

    By providing an intense and clean source of antiprotons for the first time, LEAR has opened many fields of research. Although it is not easy to summarise its versatile physics programme in a few lines, this article is an attempt to do justice to the 27 experiments performed during 14 years of running and to their successful results.   LEAR complex, September 1983. In the early days of LEAR operation, the antiproton intensity was quite limited and the machine was mostly used for studying antiprotonic atoms and interactions of low-energy antiprotons with nuclei. Physicists were also performing measurements of cross-sections (total, elastic, charge exchange) as a function of the antiproton momentum. These first experiments provided valuable insights into the properties of nucleon-antinucleon interactions, including their spin structure, and ruled out the existence of hypothesized multiquark states of matter referred to as “baryonium”. The ASTERIX experiment...

  19. Ruin and Revolution in ``Hamlet."

    Science.gov (United States)

    Usher, P. D.

    1999-05-01

    In the cosmic allegorical interpretation of Shakespeare's "Hamlet" (BAAS 28, 859 & 1305, 1996; Mercury 26:1, 20, 1997; RPS 18:3, 6, 1997; Giornale di Astronomia 24:3, 27, 1998), the usurper King Claudius, namesake of Ptolemy, personifies geocentricity. Textual support for this reading is found in 1.2 where Hamlet is associated with the Sun, as befits a rightful heir, while Claudius is associated with the Earth. In 3.3 Claudius fears Hamlet's antics. Rosencrantz states that the lives of many depend on the well-being of the King. He warns that if the King were to be imperiled, his subjects, those "ten thousand lesser things", would fall in a "boisterous ruin" along with "each small annexment" and "petty consequence." These 10,000 lesser lights are the naked eye stars (mv ~ 6.5) which would collapse with the demise of the pre-Diggesian firmament, along with ancient planets and their geometrical contrivances. In 5.1 Shakespeare puns on "De revolutionibus" when he refers to "fine revolution." The double meaning of "revolution" (alteration, orbital motion) was in use long before 1600. Since "revolution" is used in the context of digging, it may refer as much to the Diggesian as the Copernican Revolution. Shakespeare's prescience is revealed by his anticipation of change, as encapsulated geocentricity is transformed to stellar boundlessness, while his presence is suggested by fatherly concerns and ghost-like direction.

  20. LEAR looks ahead

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1985-06-15

    From 19 to 26 January in Tignes in the French Alps, 180 members of CERN's newest physics community met to review progress and discuss plans for the future. These physicists use the LEAR low energy antiproton ring which came into action in 1983 and whose unique low energy beams have attracted an unanticipated level of participation from all over the world.

  1. LEAR: antiproton extraction lines

    CERN Multimedia

    Photographic Service

    1992-01-01

    Antiprotons, decelerated in LEAR to a momentum of 100 MeV/c (kinetic energy of 5.3 MeV), were delivered to the experiments in an "Ultra-Slow Extraction", dispensing some 1E9 antiprotons over times counted in hours. Beam-splitters and a multitude of beam-lines allowed several users to be supplied simultaneously.

  2. LEAR construction completed

    CERN Multimedia

    CERN PhotoLab

    1982-01-01

    In July 1982, LEAR construction was completed, the individual systems had been dry-tested. On 16 July, the first 50 MeV (309 MeV/c) protons from Linac 1 were injected and circulated. On 11 October, the first antiprotons from the AA, decelerated in the PS to 609 MeV/c, were injected. Also in 1982, acceleration, deceleration and stochastic cooling were successfully tested. See 9007366 for a more detailed description. See also 8201061, 8204131, 8309026.

  3. Hamlet the Humanist

    Institute of Scientific and Technical Information of China (English)

    刘恒

    2014-01-01

    William Shakespeare has left us the remarkable tragedy Hamlet, a typical novel in which the readers are deeply im-pressed by Hamlet, a special hero of his kind and also a humanist in the Renaissance Period.

  4. Hamlet and psychiatry intertwined.

    Science.gov (United States)

    Rotstein, Sarah

    2018-05-01

    This article considers selected landmarks in the history of psychiatry and their impact on Hamlet productions, including Burton's Anatomy of Melancholia, Emil Kraepelin's manic-depression, Freud's oedipal complex and R.D. Laing's 'divided self'. Additionally, this article considers the way Shakespeare's Hamlet has influenced the course of psychiatry. The linkages between psychiatry and Hamlet have existed since the 17th century, and perhaps Shakespeare's Hamlet should have a place on every psychiatrist's shelf.

  5. Physics with antiprotons at LEAR

    International Nuclear Information System (INIS)

    Kilian, K.

    1984-01-01

    The low energy antiproton ring LEAR started to work at CERN in 1983. It provides clean anti p beams of much higher intensity and much better quality than available so far in the range from 0.1 to 2 GeV/c momentum. 16 of the 17 accepted experiments are installed and 14 of them took first data in 1983. After approx.= 240 hours of LEAR operation very first results are available. One can expect that exciting physics results be produced in many different domains provided LEAR gets enough anti p in the future. (orig.)

  6. Symposium on Highlights from 14 years of LEAR Physics : "LEAR Performance" by M. Chanel

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields: M. Chanel "LEAR Performance"

  7. Coil for LEAR extraction septum

    CERN Multimedia

    CERN PhotoLab

    1982-01-01

    Which way does the current flow ? This intriguing object is the coil for the LEAR extraction septum. There were two septa, first a thin one, then this one, not so thin, somewhat on the borderline between septum and bending magnet.

  8. Internal targets for LEAR

    International Nuclear Information System (INIS)

    Kilian, K.; Gspann, J.; Mohl, D.; Poth, H.

    1984-01-01

    This chapter considers the use of thin internal targets in conjunction with phase-space cooling at the Low-Energy Antiproton Ring (LEAR). Topics considered include the merits of internal target operation; the most efficient use of antiprotons and of proton synchrotron (PS) protons, highest center-of-mass (c.m.) energy resolution; highest angular resolution and access to extreme angles; the transparent environment for all reaction products; a windowless source and pure targets; highest luminosity and count rates; access to lowest energies with increasing resolution; internal target thickness and vacuum requirements; required cooling performance; and modes of operation. It is demonstrated that an internal target in conjunction with phase-space cooling has the potential of better performance in terms of the economic use of antiprotons and consequently of PS protons; energy resolution; angular resolution; maximum reaction rate capability (statistical precision); efficient parasitic operation; transparency of the target for reaction products; access to low energies; and the ease of polarized target experiments. It is concluded that all p - experiments which need high statistics and high p - flux, such as studies of rare channels or broad, weak resonance structures, would profit from internal targets

  9. In the LEAR control room

    CERN Multimedia

    CERN PhotoLab

    1983-01-01

    View into the control room of the Low Energy Antiproton Ring (LEAR). Edgar Asseo (sitting) and Dieter Möhl and Georges Carron reflecting upon some beam dynamics (or hardware?) problem. Vassilis Agoritsas, in the background, leaning over a plan or a keyboard. LEAR in its early years (1982 to about 1990) was run from this local control room in building 363 close to the end of the PS South Hall, where the ring was installed. Later-on the operation was surveyed from the PS main control room.

  10. Shaw on Hamlet

    Science.gov (United States)

    Dukore, Bernard F.

    1971-01-01

    Shaw's preoccupation with Hamlet resonates in his creative writing. Article documents this statement not only by examining his novels and plays but by searching through prefaces, postscripts, reviews, letters, speeches, etc. that span Shaw's lifetime. (Author/RB)

  11. The jetset experiment at Lear

    International Nuclear Information System (INIS)

    Eisenstein, R.A.; Armenteros, R.; Bassi, D.; Birien, P.; Bock, R.; Buzzo, A.; Chesi, E.; Debevec, P.; Drijard, D.; Dutty, W.; Easo, S.; Eisenstein, R.A.; Fearnley, T.; Ferro-Luzzi, M.; Franz, J.; Greene, R.; Hamann, N.; Hartfield, R.; Harris, P.; Hertzog, D.; Hughes, S.; Johansson, T.; Jones, R.; Kilian, K.; Kirsebom, K.; Klett, A.; Korsmo, H.; Lovetere, M.; Lundby, A.; Macri, M.; Marinelli, M.; Mattera, L.; Moueellic, B.; Oelert, W.; Ohlsson, S.; Perreau, J.; Pia, M.G.; Pozzo, A.; Price, M.; Reimer, P.; Roehrich, K.; Roessle, E.; Santroni, A.; Scalisi, A.; Schmitt, H.; Steinkamp, O.; Stugu, B.; Tayloe, R.; Terreni, S.; Urban, H.; Zipse, H.; University of Genoa; Univesity of Illinois; IKP at KFA Juelich; University of Oslo; University of Uppsala)

    1991-01-01

    The Jetset experiment (PS 202) at LEAR will search for gluonic hadrons and other exotics in the interaction of in-flight antiprotons with protons at rest. The mass range to be covered extends from 1.96 to 2.43 GeV. Our experiment uses a molecular hydrogen cluster jet target which is inserted in the LEAR ring and is surrounded by a general-purpose detetor of advanced design. In ''Phase I'' the detector has been constructed to provide selection at the trigger level of four kaon events, allowing a search for resonances in the OZI-forbidden, gluon-rich reaction bar pp→φφ→4K. The combination of LEAR with our detector is unique in that it allows scanning over a large momentum range with excellent momentum resolution, implying corresponding excellent mass resolution. The physics interest in this process is outlined briefly, and the design of the detector elments is described in some detail. A brief discussion of possible upgrade paths (''Phase II'') for the detecor is given at the end

  12. The jetset experiment at Lear

    Energy Technology Data Exchange (ETDEWEB)

    Eisenstein, R.A. (Nuclear Physics Laboratory, University of Illinois, Champaign, IL 61820 (CH)); Armenteros, R. (CERN (Switzerland)); Bassi, D.; Birien, P.; Bock, R.; Buzzo, A.; Chesi, E.; Debevec, P.; Drijard, D.; Dutty, W.; Easo, S.; Eisenstein, R.A.; Fearnley, T.; Ferro-Luzzi, M.; Franz, J.; Greene, R.; Hamann, N.; Hartfield, R.; Harris, P.; Hertzog, D.; Hughes, S.; Johansson, T.; Jones, R.; Kilian, K.; Kirsebom, K.; Klett, A.; Korsmo, H.; Lovetere, M.; Lundby, A.; Macri, M.; Marinelli, M.; Mattera, L.; Moueellic, B.; Oelert, W.; Ohlsson, S.; Perreau, J.; Pia, M.G.; Pozzo, A.; Price, M.; Reimer, P.; Roehrich, K.; Roessle, E.; Santroni, A.; Scalisi, A.; Schmitt, H.; Steinkamp, O.; Stugu, B.; Tayloe, R.; Terreni, S.; Urban, H.; Zipse, H. (University of (Freiburg) University of Genoa Univesity of Illinois (usa) IKP at KFA Juelich University of Oslo University of Uppsala)

    1991-04-10

    The Jetset experiment (PS 202) at LEAR will search for gluonic hadrons and other exotics in the interaction of in-flight antiprotons with protons at rest. The mass range to be covered extends from 1.96 to 2.43 GeV. Our experiment uses a molecular hydrogen cluster jet target which is inserted in the LEAR ring and is surrounded by a general-purpose detetor of advanced design. In Phase I'' the detector has been constructed to provide selection at the trigger level of four kaon events, allowing a search for resonances in the OZI-forbidden, gluon-rich reaction {bar p}p{r arrow}{phi}{phi}{r arrow}4K. The combination of LEAR with our detector is unique in that it allows scanning over a large momentum range with excellent momentum resolution, implying corresponding excellent mass resolution. The physics interest in this process is outlined briefly, and the design of the detector elments is described in some detail. A brief discussion of possible upgrade paths ( Phase II'') for the detecor is given at the end.

  13. Theatrum Mundi: Ur-Hamlet

    DEFF Research Database (Denmark)

    Christoffersen, Erik Exe

    2009-01-01

    Om Odin Teatrets dramaturgier og om Barbas dramaturgi-begreb relateret til forestillingen Ur-Hamlet (2006)......Om Odin Teatrets dramaturgier og om Barbas dramaturgi-begreb relateret til forestillingen Ur-Hamlet (2006)...

  14. The Hamlet Project.

    Science.gov (United States)

    Dynak, Dave

    1998-01-01

    Describes a three-week summer theater program for middle and high school students. Discusses the reconstructing of Shakespeare's play "Hamlet" by students in the class from prior viewings of movie versions of the play and from students' past experiences with the play. Includes the play script as rewritten by the students. (CR)

  15. Don Quijote y Hamlet

    Directory of Open Access Journals (Sweden)

    Lúdovik B. Osterc

    2002-12-01

    Hamlet está loco, es un alucinado que duda de sus propios sentidos. Para él existe sólo un lado negro de la existencia, su único objeto es llegar más pronto al descubrimiento del crimen. Es egocentrico, ne cree en nada, eternamente mira en su interior, se alimenta en su desprecio de sí mismo y su sufrimiento es mucho más doloroso.que aquel de Don Quijote. Don Quijote, al contrario, cree en el hombre y su futuro. Su ideal es implantar por la fuerza, la verdad, el bien y la justicia en la tierra. Para servir a su ideal, está dispuesto a sufrir todas las posibles privaciones. Representa la fe en la verdad. Es ridículo y quizás el más cómico tipo disenado jamás por un literato. Hamlet es el hijo del rey muerte, mientras que Don Quijote está pobre. Se hace los enemigos imaginarios y lucha contra ellos, mientras que Hamlet no cree en las ilusiones (siempre duda, y tampoco no combatiría si supiera que son sinónimos de opresores. Continua con la examinación de la actitud del pueblo o sus representantes hacia Don Quijote y Hamlet y viceversa. Polonia es el representante de las multitudes populares ante Hamlet, Sancho lo es ante su senor. El primero es de sano pensamiento y al mismo tiempo un viejo charalatán. Para él Hamlet no es tanto un loco como un nino y le parece inútil para la sociedad. Sancho Pansa está persuadido de que su senor está loco, pero le está leal hasta la muerte. Don Quijote simpatiza profundamente con el pueblo, pero la única persona con la que se entiende verdaderamente es Sancho Pansa (uno no puede vivir sin otro. La actitud de Hamlet es completamente diferente, él desprecia las multitudes populares, porque también desprecia a sí mismo. social: el tedio, el hastío, el descontento de la vida, desorientación espiritual y la eclipse de la fe, miéntras que Don Quijote encarna el mundo libre, bien estar y la felicidad de los seres humanos. Por eso y porque es un ideal el más humano, generoso, noble y elevado, el autor del

  16. CERN: Important summer for LEAR physics

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    An integral part of CERN's comprehensive antiproton facilities is the LEAR low energy antiproton ring which came into action for physics in 1983 and has gone on to host many experiments looking at a wide range of physics topics. With CERN's big SPS proton-antiproton collider now in what could be its final production physics run after an illustrious career which began in 1981, the face of antiproton physics at CERN will change over the next few years. However LEAR runs independently of high energy antiproton operations, and any phasing out of collider operations has no direct impact on LEAR

  17. CERN: Important summer for LEAR physics

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1990-12-15

    An integral part of CERN's comprehensive antiproton facilities is the LEAR low energy antiproton ring which came into action for physics in 1983 and has gone on to host many experiments looking at a wide range of physics topics. With CERN's big SPS proton-antiproton collider now in what could be its final production physics run after an illustrious career which began in 1981, the face of antiproton physics at CERN will change over the next few years. However LEAR runs independently of high energy antiproton operations, and any phasing out of collider operations has no direct impact on LEAR.

  18. An Interview with Dr. Walter Lear

    Directory of Open Access Journals (Sweden)

    The Editors

    2009-03-01

    Full Text Available In this issue of the English version of Social Medicine we are publishing the first of several pamphlets loaned to us by the US Health Activism History Collection. To introduce this collection we travelled to Philadelphia on June 18, 2008 to interview Dr. Walter J. Lear. Dr Lear, born in 1923, is the person responsible for the collection. In a wide-ranging interview in his home Dr. Lear discussed his personal background, the origins and purpose of the collection, the impact of the McCarthy period on the US health left, as well as his vision for the future.

  19. LEAR is dead, long live LEIR!

    CERN Multimedia

    2004-01-01

    The LEAR (Low Energy Antiproton Ring) experiment has now been dismantled. Only the dipoles remain for use in the future LEIR (Low Energy Ion Ring) experiment, the new ring which will supply lead ions to the LHC experiments.

  20. Hamlet and psychoanalytic experience.

    Science.gov (United States)

    Schwaber, Paul

    2007-01-01

    Hamlet draws us into its rendered world, enabling us to experience it with depth, awareness, and resonance, in a mode we recognize as aesthetic. By way of Shakespeare's play--primarily the first act--and a detailed case study, aesthetic and psychoanalytic experience are compared, to suggest that, for our own analytic discourse, we revalue Freud's unease that his case studies read like short stories.

  1. Olivier's 'Essay on Hamlet'

    Directory of Open Access Journals (Sweden)

    Koprivica Zoran

    2017-01-01

    Full Text Available Laurence Olivier's Hamlet is more a renaissance character, a melancholic and a daydreamer, than a man of action, unlike his Henry V and Richard III film adaptations. However, it seems that Olivier showed outstanding courage not in his extremely liberal approach to interpreting this Shakespeare's tragedy, but in literal application of Freud's model on his inner problems, seen through the prism of the professor Ernest Johnson. Transposing Shakespeare's original text, starting with its global features, he abstracts numerous and diversified eventful and associative moments which might burden the polyphonic structure of his own - film story. Moreover, Olivier wants to avoid its dramatic deconstruction and focuses the viewer's attention to the climactic moments. However, dramatically the strongest and most effective scenes in his film adaptation of Hamlet are the ones related to the use of camera, that is to say, its movement and analyticity. The intention was to point not only to the ostentatious difference between cinematographic and theatrical stylisation, but, to a certain extent, he defines the viewer's standpoint. In his 'essay on Hamlet', Olivier does not consider chronology, that is to say, the problem of temporal relations. The visual structure of the film and its dynamics are determined a priori by the rhythmic parameters of the Elsinore's labyrinthic space.

  2. Why must Hamlet Delay in the Revenge?

    Institute of Scientific and Technical Information of China (English)

    贾艳平; 金梅

    2013-01-01

    Hamlet is the greatest tragedy play of William Shakespeare. Hamlet is centred on the hesitation and the options of the heroic Hamlet's action. The purpose of the paper is to give an analysis of the essential reason of Hamlet ’s delay in his revenge. The thesis is arranged as following:firstly, it focuses on the analysis of the complicated characteristics of Hamlet;then, it will anal-yse the options that Hamlet has. Hamlet is great with absolute no doubt.

  3. Mason & Dixon and Hamlet

    Directory of Open Access Journals (Sweden)

    Celia Wallhead

    2014-08-01

    Full Text Available Although there is no explicit comparison in 'Mason & Dixon' of the astronomer protagonist Charles Mason to the eponymous hero of Shakespeare's masterpiece, indisputable references to the play are to be found in the novel. Mason is endowed with qualities which mirror Hamlet's virtues and vices: he is a leader and a man of education and wit, though his metaphysical longings entice him towards madness and suicide. He is emburdened with a  deep melancholy stemming from bereavement, loss of love, the hauntings of a ghost, indecision, even cowardice and frustrated ambition.

  4. Hamlet: virtù man

    OpenAIRE

    Roio, Marcos Del [UNESP; Martinez, Vinício C. [UNESP

    2008-01-01

    O artigo traz algumas relações/semelhanças entre Hamlet, de Shakespeare, e O Príncipe de Maquiavel. Portanto, pela “perspectiva” da Razão de Estado e não pela versão reducionista do “maquiavelismo” (maniqueísmo político), também podemos observar uma teoria política em Shakespeare. Palavras-chave: Maquiavel. Príncipe. Virtù. Hamlet. Astúcia. The article reports some relations/similarities between Shakespeare’s Hamlet and Machiavelli’s Prince. Therefore, by the Sta...

  5. Irony in Tennyson's "Little Hamlet".

    Science.gov (United States)

    Harrison, Antony H.

    1981-01-01

    Points out similarities between the events and characters of Tennyson's "Maud" and Shakespeare's "Hamlet." Identifies traits which "Maud" shares with Spasmodic poetry. Argues that Tennyson consciously employed these similarities to expose the deficiencies of the Spasmodic school. (DMM)

  6. Compact oleic acid in HAMLET.

    Science.gov (United States)

    Fast, Jonas; Mossberg, Ann-Kristin; Nilsson, Hanna; Svanborg, Catharina; Akke, Mikael; Linse, Sara

    2005-11-07

    HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a complex between alpha-lactalbumin and oleic acid that induces apoptosis in tumor cells, but not in healthy cells. Heteronuclear nuclear magnetic resonance (NMR) spectroscopy was used to determine the structure of 13C-oleic acid in HAMLET, and to study the 15N-labeled protein. Nuclear Overhauser enhancement spectroscopy shows that the two ends of the fatty acid are in close proximity and close to the double bond, indicating that the oleic acid is bound to HAMLET in a compact conformation. The data further show that HAMLET is a partly unfolded/molten globule-like complex under physiological conditions.

  7. Physics with antiprotons at LEAR in the ACOL ERA. Proceedings of the 3. LEAR Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Gastaldi, U.; Klapisch, R.; Richard, J.M.; Tran Thanh Van, J. (eds.)

    1985-01-01

    The programme covered the following topics: accelerator aspects (anti-p production, LEAR, advanced developments, cooling, LEAR design inspired machines). Nucleon antinucleon interactions (panti-p atom, scattering, annihilation, spin effects, antineutron physics, antibaryon physics). Spectroscopy (light mesons, hybrids, glueballs, baryonia, quarkonia). Rare channels (form factors, CP, CPT, C, T violation, quantum mechanics tests) anti-p nucleus interactions (exotic atoms, scattering, annihilation, hypernuclei). New ideas (antigravity, high precision experiments). New detectors (new experiments, general and/or technical aspects).

  8. HAMLET E O PODER

    OpenAIRE

    Gomes, Analice Franco; Parente Rebouças, Marcus Vinícius

    2017-01-01

    Este artigo científico analisa a tragédia shakespeariana de Hamlet sob o prisma específico das relações de poder, estabelecendo uma interface entre a Ciência Política e a Arte Teatral, com o propósito de produzir aportes teóricos que permitam melhor compreender o fenômeno político. Além de considerações acerca de dados biográficos de Shakespeare e de aspectos gerais a respeito da peça “Hamlet”, delineou-se um conceito de poder enquanto relação humana, adotando-se Michel Foucault como referenc...

  9. Physics at SuperLEAR: Workshop summary

    International Nuclear Information System (INIS)

    Dover, C.B.

    1990-11-01

    The major themes of the physics program to be explored at the proposed SuperLEAR facility are summarized. These include the study of charmonium spectroscopy, searches for CP violation in hyperon decays, exploration of hadron spectroscopy and gluon dynamics, particularly of non-Q bar Q systems, and bar p-nucleus annihilation as a means of probing the mechanisms of charm and strangeness production as well as the dynamics of heated nuclear matter. 40 refs., 3 tabs

  10. LEAR: a machine ahead of its time

    CERN Multimedia

    Katarina Anthony

    2012-01-01

    Described as a “machine physicist's concert platform”, the Low Energy Antiproton Ring (LEAR) was everything at once: an accelerator, a storage ring, a decelerator, a cooler ring and a beam stretcher. 2012 marks the 30th anniversary of its start-up and an opportunity for the Bulletin to take a look back at the history of this remarkable machine.   This article is a tribute to Dieter Möhl, one of LEAR's founding fathers, who passed away at the end May.   Kilian's graph shows the phase space density of antiprotons produced from 26 GeV protons vs. antiproton momentum. Note that this density is significantly higher at low momentum for a decelerated beam. (Graph published in the 1977 "Low Energy Antiproton Factory" paper.) Like most great CERN projects, LEAR began with a dream and a coffee between colleagues. The year was 1976, the coffee was shared by Kurt Kilian and Diete...

  11. HAMLET treatment delays bladder cancer development.

    Science.gov (United States)

    Mossberg, Ann-Kristin; Hou, Yuchuan; Svensson, Majlis; Holmqvist, Bo; Svanborg, Catharina

    2010-04-01

    HAMLET is a protein-lipid complex that kills different types of cancer cells. Recently we observed a rapid reduction in human bladder cancer size after intravesical HAMLET treatment. In this study we evaluated the therapeutic effect of HAMLET in the mouse MB49 bladder carcinoma model. Bladder tumors were established by intravesical injection of MB49 cells into poly L-lysine treated bladders of C57BL/6 mice. Treatment groups received repeat intravesical HAMLET instillations and controls received alpha-lactalbumin or phosphate buffer. Effects of HAMLET on tumor size and putative apoptotic effects were analyzed in bladder tissue sections. Whole body imaging was used to study HAMLET distribution in tumor bearing mice compared to healthy bladder tissue. HAMLET caused a dose dependent decrease in MB49 cell viability in vitro. Five intravesical HAMLET instillations significantly decreased tumor size and delayed development in vivo compared to controls. TUNEL staining revealed selective apoptotic effects in tumor areas but not in adjacent healthy bladder tissue. On in vivo imaging Alexa-HAMLET was retained for more than 24 hours in the bladder of tumor bearing mice but not in tumor-free bladders or in tumor bearing mice that received Alexa-alpha-lactalbumin. Results show that HAMLET is active as a tumoricidal agent and suggest that topical HAMLET administration may delay bladder cancer development. Copyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  12. Hamlet: virtù man

    OpenAIRE

    Roio, Marcos Del; UNESP - Universidade Estadual Paulista / Marília - SP; Martinez, Vinício C.; UNESP - Universidade Estadual Paulista / Marília - SP

    2008-01-01

    The article reports some relations/similarities between Shakespeare’s Hamlet and Machiavelli’s Prince. Therefore, by the State Reasoning “perspective” and not by the reductionism version of “machiavellism” (political maniqueism), we can also observe a political theory in Shakespeare. O artigo traz algumas relações/semelhanças entre Hamlet, de Shakespeare, e O Príncipe de Maquiavel. Portanto, pela “perspectiva” da Razão de Estado e não pela versão reducionista do “maquiavelismo” (maniqueísm...

  13. Translational Implications of Tamil "Hamlets."

    Science.gov (United States)

    Kanakaraj, S.

    1994-01-01

    Discusses the use of translation when teaching English as a Second Language in a Tamil context. Singles out the fencing episode in Shakespeare's "Hamlet" to illustrate the difficulties of translating cultural aspects. Concludes that successful translations of Shakespeare into Indian languages should involve collaboration between…

  14. Depressive illness delayed Hamlet's revenge.

    Science.gov (United States)

    Shaw, A B; Pickering, Neil

    2002-12-01

    If Hamlet had not delayed his revenge there would have been no play. Many explanations of the delay have been offered in the last four centuries. None is convincing. The interpretation which best fits the evidence best is that Hamlet was suffering from an acute depressive illness, with some obsessional features. He could not make a firm resolve to act. In Shakespeare's time there was no concept of acute depressive illness, although melancholy was well known. Melancholy, however, would have been seen as a character defect. In the tragic model the hero brings himself and others to ruin because of a character defect. Thus, at the time, the play conformed to the tragic model. With today's knowledge, it does not. This analysis adds to, but does not replace, other insights into the play.

  15. Reading Hamlet. The NCTE Chalkface Series.

    Science.gov (United States)

    Mellor, Bronwyn

    This book, for grades 9-12, contains a wealth of ideas and practical activities for studying Shakespeare's "Hamlet." The first section, "Revenge Tragedy," provides background materials to help prepare students to read "Hamlet," including a discussion of revenge tragedies, comparisons to other plays from the period,…

  16. HAMLET: functional properties and therapeutic potential.

    Science.gov (United States)

    Ho C S, James; Rydström, Anna; Trulsson, Maria; Bålfors, Johannes; Storm, Petter; Puthia, Manoj; Nadeem, Aftab; Svanborg, Catharina

    2012-10-01

    Human α-lactalbumin made lethal to tumor cells (HAMLET) is the first member in a new family of protein-lipid complexes that kills tumor cells with high selectivity. The protein component of HAMLET is α-lactalbumin, which in its native state acts as a substrate specifier in the lactose synthase complex, thereby defining a function essential for the survival of lactating mammals. In addition, α-lactalbumin acquires tumoricidal activity after partial unfolding and binding to oleic acid. The lipid cofactor serves the dual role as a stabilizer of the altered fold of the protein and a coactivator of specific steps in tumor cell death. HAMLET is broadly tumoricidal, suggesting that the complex identifies conserved death pathways suitable for targeting by novel therapies. Sensitivity to HAMLET is defined by oncogene expression including Ras and c-Myc and by glycolytic enzymes. Cellular targets are located in the cytoplasmic membrane, cytoskeleton, mitochondria, proteasomes, lysosomes and nuclei, and specific signaling pathways are rapidly activated, first by interactions of HAMLET with the cell membrane and subsequently after HAMLET internalization. Therapeutic effects of HAMLET have been demonstrated in human skin papillomas and bladder cancers, and HAMLET limits the progression of human glioblastomas, with no evidence of toxicity for normal brain or bladder tissue. These findings open up new avenues for cancer therapy and the understanding of conserved death responses in tumor cells.

  17. Theatrum Mundi: Odin Teatret's Ur-Hamlet

    DEFF Research Database (Denmark)

    Christoffersen, Erik Exe

    2008-01-01

    Analyse af Odin Teatrets forestilling Ur-Hamlet opført på Kronborg 2006 med 100 medvirkende fra hele verden.......Analyse af Odin Teatrets forestilling Ur-Hamlet opført på Kronborg 2006 med 100 medvirkende fra hele verden....

  18. Study of Antineutron Production at LEAR

    CERN Document Server

    2002-01-01

    The aim of this experiment is the study of antineutron ($\\bar{n}$) production at LEAR as a first step for the investigation of $\\bar{n}$-p $\\bar{n}$-n physics. A good method of producing high-quality $\\bar{n}$ beams is that of using the charge-exchange (CEX) reaction @*p~@A~$\\bar{n}$n on an external LH^2 target. The production of $\\bar{n}$ at 0|0 (see figure) may be most useful for some experiments, the production at different angles with the simultaneous detection of the associated neutron (tagged beam) most powerful for other measurements.\\\\ \\\\ The $\\bar{n}$ calorimeter consists of ten equal modules: each one is made of an iron slab, a scintillator wall and a plane of x-y streamer tubes, with a detecting area of @=~1~m|2. The $\\bar{n}$ calorimeter allows the determination of the time and the location of $\\bar{n}$ annihilations.

  19. Antiproton-nucleon physics at LEAR

    International Nuclear Information System (INIS)

    Duclos, J.

    1985-02-01

    Antiproton beams from LEAR have been supplied in 1984 to 16 experiments about 10 12 particules at 200, 300, 600 and 1500 MeV/c have been delivered during 60 days of machine time. In nuclear physics, anti p-nuclei scattering and atomic X rays have been measured. In hydrogen, atomic L and K transitions have been detected. Searches have been made for baryonia with rather negative results. The p anti p annihilation at rest in various meson channels, selecting the initial anti p-wave, has been observed. The annihilation in electron-positron pair at rest and in flight has been measured and a value of the proton form factor is derived [fr

  20. Physics with antiprotons at LEAR in the ACOL ERA

    International Nuclear Information System (INIS)

    Gastaldi, U.; Klapisch, R.; Richard, J.M.; Tran Thanh Van, J.

    1985-01-01

    The programme covered the following topics: accelerator aspects (anti-p production, LEAR, advanced developments, cooling, LEAR design inspired machines). Nucleon antinucleon interactions (panti-p atom, scattering, annihilation, spin effects, antineutron physics, antibaryon physics). Spectroscopy (light mesons, hybrids, glueballs, baryonia, quarkonia). Rare channels (form factors, CP, CPT, C, T violation, quantum mechanics tests) anti-p nucleus interactions (exotic atoms, scattering, annihilation, hypernuclei). New ideas (antigravity, high precision experiments). New detectors (new experiments, general and/or technical aspects)

  1. No Hamlet, two Hamlets: The Shakespearean Tragedy Directed by Carmelo Bene and Celestino Coronado

    Directory of Open Access Journals (Sweden)

    Armando Rotondi

    2014-12-01

    Full Text Available The Italian artist Carmelo Bene and the British director Celestino Coronado have worked intensively on Shakespeare and in particular on Hamlet, but giving opposing interpretations of the work. In his Un Amleto di Meno (1973, Carmelo Bene, taking as starting point Jules Laforgue’s Hamlet, ou les suites de le pitié filiale (1877, redefines the drama of Hamlet,refusing to see him as a man who wants to escape his destiny. In Bene’s adaptation, Hamlet disappears from the stage. By contrast, Celestino Coronado, in his film version in 1976, underlines the presence of Hamlet on the screen, casting twins, Anthony and David Meyer, in the role and working on the idea of a Shakespearean Doppelgänger. This paper aims to analyze the specific elements of the two adaptations of Hamlet, in which there is the common presence of the Lacanian psychoanalysis.

  2. "Hamlet" rändab Gdanskisse

    Index Scriptorium Estoniae

    2004-01-01

    Theatrum mängib 2. ja 3. aug. Gdanskis rahvusvahelise Shakespeare'i - festivali raames oma lavastust "Hamlet". Theatrumi kunstiline juht L. Peterson annab Poola teatrikoolide üliõpilastele ka meistriklassi

  3. Hamlet and Japanese Men of Letters

    Directory of Open Access Journals (Sweden)

    Kawachi Yoshiko

    2016-12-01

    Full Text Available Shakespeare has exerted a powerful influence on Japanese literature since he was accepted in the second half of the nineteenth century. Particularly Hamlet has had a strong impact on Japanese men of letters and provided them with the impetus to revive the play in contemporary literature. In this paper I discuss how they have utilized Hamlet for their creative activity and enriched Japanese literature.

  4. Hamlet er manden i mit liv

    DEFF Research Database (Denmark)

    Rösing, Lilian Munk

    2009-01-01

    Hamlet er manden i mit liv. Min elskede. Jeg har en drøm om at frelse ham. At redde ham ud af sin mors soveværelse og ind i mit. Væk fra det ødipale Helvede han befinder sig i, fastlåst mellem et svin af en faderskikkelse (Claudius) og en alt for idealiseret far (gamle Hamlet), vågende over sin m...

  5. Symposium on Highlights from 14 years of LEAR Physics : "AD Project" by S. Maury

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields: S. Maury "AD Project"

  6. Symposium on Highlights from 14 years of LEAR Physics: "Light Antiprotonic Atoms" by R. Hayano

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  7. Symposium on Highlights from 14 years of LEAR Physics : R. Landua (chairman)

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  8. Symposium on Highlights from 14 years of LEAR Physics : "Nuclear Physics" by T. von Egidy

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 145 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  9. Symposium on Highlights from 14 years of LEAR Physics : "Meson spectroscopy" by H. Koch

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  10. Symposium on Highlights from 14 years of LEAR Physics : "Annihilation at Rest" by U. Gastaldi

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  11. Symposium on Highlights from 14 years of LEAR Physics : "Annihilation in Flight" by D. Hertzog

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  12. Studies of Lear antiproton deceleration: radiofrequency quadripole or synchrotron

    International Nuclear Information System (INIS)

    Iazzourene, F.

    1987-06-01

    The aim of this work is to study a radiofrequency quadrupole (RFQ) and a synchrotron as decelerating systems for antiprotons extracted from the Low Energy Antiproton Ring (LEAR) at CERN. Antiprotons at energies lower than those available from LEAR are need by some experiments, eg. the measurement of the mass difference between protons and antiprotons with 10 -9 accuracy, using a Smith and Princeton spectrometer, and the measurement of gravitation on the antiprotons, using a trap. Depending on the LEAR performances, one can conclude that the RFQ is suitable for the experiment on the gravitation, and the synchrotron, owing to its electron cooling system, is a better solution for the experiment on the mass difference measurement, because of the very small acceptance of the spectrometer [fr

  13. HAMLET interacts with histones and chromatin in tumor cell nuclei.

    Science.gov (United States)

    Düringer, Caroline; Hamiche, Ali; Gustafsson, Lotta; Kimura, Hiroshi; Svanborg, Catharina

    2003-10-24

    HAMLET is a folding variant of human alpha-lactalbumin in an active complex with oleic acid. HAMLET selectively enters tumor cells, accumulates in their nuclei and induces apoptosis-like cell death. This study examined the interactions of HAMLET with nuclear constituents and identified histones as targets. HAMLET was found to bind histone H3 strongly and to lesser extent histones H4 and H2B. The specificity of these interactions was confirmed using BIAcore technology and chromatin assembly assays. In vivo in tumor cells, HAMLET co-localized with histones and perturbed the chromatin structure; HAMLET was found associated with chromatin in an insoluble nuclear fraction resistant to salt extraction. In vitro, HAMLET bound strongly to histones and impaired their deposition on DNA. We conclude that HAMLET interacts with histones and chromatin in tumor cell nuclei and propose that this interaction locks the cells into the death pathway by irreversibly disrupting chromatin organization.

  14. Status of the CP lear experiment and first results

    International Nuclear Information System (INIS)

    Santoni, C.; Adler, R.; Angelopoulos, A.; Apostolakis, A.; Aslanides, E.; Backenstoss, G.; Bee, C.B.; Bennet, J.; Beveren, E.V.; Bloch, P.; Bula, C.; Burgun, G.; Carlson, P.; Carvalho, J.; Charalambous, S.; Chardalas, M.; Cobbaert, H.; Dedoussis, S.; Dejardin, M.; Derre, J.; Dodgson, M.; Doussee, J.C.; Duclos, J.; Ealet, A.; Eckart, B.; Faravel, L.; Fassnacht, P.; Faure, J.L.; Felder, C.; Ferreira-Marques, R.; Fetscher, W.; Fidecaro, M.; Filipcic, A.; Francis, D.; Fry, J.; Fuglesang, C.; Gabathuler, E.; Gamet, R.; Garreta, D.; Geralis, T.; Gerber, H.J.; Go, A.; Gumpliger, P.; Guyot, C.; Harrison, P.F.; Hayman, P.J.; Heyes, W.G.; Hollander, R.W.; Jansson, K.; Johner, H.J.; Jon-And, K.; Kerek, A.; Kern, J.; Kettle, P.R.; Kochowski, C.; Kokkas, P.; Kossionides, E.; Kreuger, R.; Lawry, T.; Gac, R. le; Machado, E.; Maley, P.; Manthos, N.; Marel, G.; Marotte, P.; Mikuz, M.; Miller, J.; Montanet, F.; Nakada, T.; Onofre, A.; Pagels, B.; Paradelis, T.; Pavlopoulos, P.; Pelucchi, F.; Pinto da Cunha, J.; Policarpo, A.; Postma, H.; Rickenbach, R.; Roberts, B.L.; Rozaki, E.; Ruf, T.; Sacks, L.; Sakeliou, L.; Sanders, P.; Sarigianis, K.; Schaller, L.; Schopper, A.; Seljak, U.; Szilagyi, S.; Tauscher, L.; Thibault, C.; Touchard, F.; Touramanis, C.; Triantis, F.; Troester, D.A.; Putte, M. van de; Eijk, C.W.W. van; Varner, G.; Vlachos, S.; Weber, P.; Witzig, C.; Zavrtanik, D.; Zimmermann, D.

    1991-01-01

    The aim of the CP LEAR experiment is to study symmetry-violation effects, making use of tagged K 0 's and anti K 0 's. The detector, although missing some electronic components, has been operational for a few weeks at the end of 1989 at the CERN Low-Energy Antiproton Ring (LEAR). At the moment, the analysis of the data is in progress. This paper gives a description of the experimental method and of the detector; the sensitivities of some measurements and some preliminary results are also discussed. (orig.)

  15. HAMLET. LITERATURE CURRICULUM VI, TEACHER AND STUDENT VERSIONS.

    Science.gov (United States)

    KITZHABER, ALBERT R.

    THIS CULMINATING UNIT OF THE 12TH-GRADE OREGON LITERATURE CURRICULUM IS BASED UPON ONE WORK, "HAMLET." THE TEACHER VERSION INCLUDES DISCUSSIONS OF (1) THE RELEVANCE OF HAMLET'S CHARACTER TO MODERN TIMES, (2) THE PROBLEMS IN THE CHARACTERIZATIONS OF THE GHOST, CLAUDIUS, AND HAMLET, (3) THE PLAY'S THREE-PHASE STRUCTURE, (4) THE PLAY'S…

  16. Antiproton-nucleus experiments at LEAR and KAON

    International Nuclear Information System (INIS)

    Yavin, A.I.

    1989-12-01

    Antimatter and matter-antimatter systems are briefly discussed. Results of the antiproton-nucleus scattering experiments at LEAR are described, with the emphasis on unfinished experiments and on proposed experiments yet untouched. A few remarks on antiproton and antideuteron experiments at KAON are then presented

  17. Hamlet — An Imperfect Humanist%Hamlet—An Imperfect Humanist

    Institute of Scientific and Technical Information of China (English)

    闫莹莹

    2017-01-01

    Hamlet is an eternal classic written by William Shakespeare. It drew much attention from the first edition and got a mixed reception. People argued about the characteristic of Hamlet during more than 400 years. Many western critics concerned Hamlet was hesitated, cowardly, oedipal and was not a humanist. However, investigators in China regarded Hamlet as a perfect humanist. It argues that the characteristic of Hamlet is so complicated, it can't be summarized in one sentence. It is sensible to make a comprehensive study on the limitation of Hamlet as a pure person in a world which the god withdraws. Began with cow-ardice and ended with peaceful death, Hamlet shows the soul of an imperfect humanist.

  18. Hamlet: homem de virtú Hamlet: virtù man

    Directory of Open Access Journals (Sweden)

    Marcos Del Roio

    2008-12-01

    Full Text Available O artigo traz algumas relações/semelhanças entre Hamlet, de Shakespeare, e O Príncipe de Maquiavel. Portanto, pela “perspectiva” da Razão de Estado e não pela versão reducionista do “maquiavelismo” (maniqueísmo político, também podemos observar uma teoria política em Shakespeare. Palavras-chave: Maquiavel. Príncipe. Virtù. Hamlet. Astúcia. The article reports some relations/similarities between Shakespeare’s Hamlet and Machiavelli’s Prince. Therefore, by the State Reasoning “perspective” and not by the reductionism version of “machiavellism” (political maniqueism, we can also observe a political theory in Shakespeare. Keywords:Machiavelli. Prince. Virtù. Hamlet. Cunning.

  19. Kuressaare Hamlet on inglane / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2000-01-01

    29.oktoobril esilinastub Eesti Televisioonis Hamleti-teemaline ingliskeelne lühimängufilm "Miski on mäda ehk Kogu vale Hamletist" ("Something is Rotten or All the Lie About Hamlet") : režissöör, stsenarist ja produtsent Ilmar Raag : OÜ Kinomees 2000

  20. Kuressaare Hamlet ahistab Opheliat / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2000-01-01

    Ilmar Raag väntab Saaremaal Hamleti-teemalist ingliskeelset mängufilmi inglise näitlejatega esialgse pealkirjaga "Miski on riigis mäda ehk Kogu vale Hamletist" ("Something is Rotten or All the Lie About Hamlet". Filmi operaator on Madis Mihkelsoo ja kunstnik Liina Unt

  1. The Thing's the Play: Doing "Hamlet."

    Science.gov (United States)

    Sowder, Wilbur H., Jr.

    1993-01-01

    Argues for the use of film in the teaching of William Shakespeare's "Hamlet" because the play was meant to be seen and heard and not just read. Outlines a method of teaching the play by which students select a scene and perform it. Gives an example of a successful student performance. (HB)

  2. "Remember Me": Memory and Action in "Hamlet".

    Science.gov (United States)

    Andrews, Michael Cameron

    1981-01-01

    Examines the relationship between Hamlet's commitments to the past and his failure to translate these commitments into action, as he permits himself to be deflected by preoccupation with the future consequences of his action. Cites supportive evidence from the text. (DMM)

  3. HAMLET - A protein-lipid complex with broad tumoricidal activity.

    Science.gov (United States)

    Ho, James C S; Nadeem, Aftab; Svanborg, Catharina

    2017-01-15

    HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a tumoricidal protein-lipid complex with broad effects against cancer cells of different origin. The therapeutic potential is emphasized by a high degree of specificity for tumor tissue. Here we review early studies of HAMLET, in collaboration with the Orrenius laboratory, and some key features of the subsequent development of the HAMLET project. The early studies focused on the apoptotic response that accompanies death in HAMLET treated tumor cells and the role of mitochondria in this process. In subsequent studies, we have identified a sequence of interactions that starts with the membrane integration of HAMLET and the activation of ion fluxes followed by HAMLET internalization, progressive inhibition of MAPK kinases and GTPases and sorting of HAMLET to different cellular compartments, including the nuclei. Therapeutic efficacy of HAMLET has been demonstrated in animal models of glioblastoma, bladder cancer and intestinal cancer. In clinical studies, HAMLET has been shown to target skin papillomas and bladder cancers. The findings identify HAMLET as a new drug candidate with promising selectivity for cancer cells and a strong therapeutic potential. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Short quadrupole, first at the SC, then at LEAR

    CERN Multimedia

    CERN PhotoLab

    1982-01-01

    Quadrupoles of this type were built for the beam lines of the 600 MeV Synchro-Cylclotron. Surplus ones were installed in the LEAR injection line. The particularity of these quads is that they are very short and that a special design, resembling the "Lambertson magnet", limits and linearizes their stray field. This was achieved by the iron between the poles extending beyond the poles.

  5. Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET.

    Science.gov (United States)

    Brest, Patrick; Gustafsson, Mattias; Mossberg, Ann-Kristin; Gustafsson, Lotta; Duringer, Caroline; Hamiche, Ali; Svanborg, Catharina

    2007-12-01

    Histone deacetylase inhibitors (HDIs) and HAMLET (human alpha-lactalbumin made lethal to tumor cells) interact with histones, modify the structure of chromatin, and trigger tumor cell death. This study investigated how the combination of HDIs and HAMLET influences cell viability, histone acetylation, and DNA integrity. The pretreatment of tumor cells with HDIs was shown to enhance the lethal effect of HAMLET and the histone hyperacetylation response to HDIs increased even further after HAMLET treatment. HDIs and HAMLET were shown to target different histone domains as HAMLET bound tailless core histones, whereas HDIs modify the acetylation of the histone tail. DNA damage in response to HAMLET was increased by HDIs. The DNA repair response (p21WAFI expression) was induced by both agonists but abolished when the two agonists were combined. The results suggest that the synergy of HDIs and HAMLET is based on different but converging death pathways, both involving chromatin alterations. We speculate that HAMLET and HDIs might be combined to promote tumor cell death in vivo.

  6. Hamlet, Performance and Chaotic Cultural Networks

    Directory of Open Access Journals (Sweden)

    Emil Rybczak

    2015-10-01

    Full Text Available Since the 1960s, chaos theory has become an important but controversial tool used by scientists and mathematicians to describe physical or theoretical systems or networks. It explains how the simple can generate the complex. Its central tenets can also provide an alternative language and means of literary interpretation. This article will explore how the principles of chaos theory can be used to close read and systematise various aspects of the language and performance of Shakespeare. The argument is built upon an analysis of Hamlet, in an effort to understand the play and its reproduction as the evolution of interconnected complex networks. Various aspects of the text will be discussed, including its language, structural and character patterning, and its reproduction through performance and cinematic adaptation. Each of these topics, and the characters, devices or ideas they discuss, constitute nodes of the complex network of Hamlet as both text and idea. Responding to the cultural analysis of other scholars, this article uses Hamlet as an ideal example of how the appropriation of scientific language can defamiliarise a particular literary or dramatic artefact. This allows fresh interpretation and understanding of its location within the broader networks of theatre and culture. I suggest the possibilities of close reading literary works through the lens of chaos and suggest how they might be applied and developed in conjunction with other texts, media or performances.

  7. ["I am but mad north-north-west"--Hamlet's portrayed delusion].

    Science.gov (United States)

    Schulte Herbrüggen, H

    1996-01-01

    the play, I must be idle" (i.e. "mad"), next in answering the king ("I fare of the chamaeleon's dish"), and once again in a particularly explicit distinction for his mother ("I am essentially not in madness, but mad in craft"). The evidence of all other instances of mad/madness represented here corroborates these findings: madness as an adopted role and not as a character trait. - It should also be noted that Shakespeare's main source (Belleforests adaptation of the Amleth-story from Saxo Grammaticus) already knew of the motive of stimulated madness as a cover for revenge. Hamlet assumes the role of a "madman" in order to have full scope for action, first, to test by help of the "play in the play" the truth of his father's apparition as a ghost demanding revenge as well as the actual guilt of Claudius and, when that is established, for preparing and executing his revenge. By acting himself, Hamlet becomes guilty and (Shakespeare having chosen the dramatic genre of tragedy) pays for his success with his life. Considering the constant border-crossings between the spheres of real persons and fictive literary figures in psychological approaches to Hamlet, we stressed the essential difference of a literary work of art from real life. At the same time, the inherent limitations of that difference must be shown as well. Although the world of belles lettres is fictive and non-existent in reality, it does not play in a vacuum. It is fed, in many ways, by the poet's experience of his own days as well as by the work's position within the realm of literary tradition (genre, sources, etc.). It is perhaps easy, to insist on the self-contained nature of literature, making literary criticism an arcane activity of a few elected professionals. The price to pay would be, as Laurence Lerner points out, that great literature will no longer tell us anything about life, and the poet's subtle insights, his wisdom, his understanding of the soul and of the world cease to enrich the general read

  8. Experimental study of charmed baryons at SuperLEAR

    International Nuclear Information System (INIS)

    Poulet, M.

    1991-01-01

    The possibility to study and detect the charmed baryons at SuperLEAR was examined. It was found that it is possible only if the search is restricted to the single charm baryons Λ c , Σ c , Ξ c . The experimental approach requires high luminosity and some complexity of the detection system. It has to be considered as a second generation jet target experiment in a range of p-bar momentum from 8 to 15 GeV/c. (R.P.) 12 refs., 2 figs

  9. "By Indirections Find Directions Out": The Soliloquies in Hamlet

    Science.gov (United States)

    Champion, Larry S.

    1976-01-01

    Article analyzed the soliloquies in Hamlet and showed that Shakespeare used the device of the soliloquy not for clarification (as he did elsewhere) but for complication instead, so that the audience is made to see Hamlet's character as consisting of diverse ingredients, a personality fragmented rather than whole. (Editor/RK)

  10. Hamlet, iscenesættelse Roger Vontobel, Staatsschauspiel Dresden

    DEFF Research Database (Denmark)

    Kuhlmann, Annelis

    2015-01-01

    Hamlet iscenesat af Roger Vontobel, Staatsschauspiel Dresden. Gæstespil på Kronborg Slot under Hamletscenens Shakespearefestival 1.-4. august 2015......Hamlet iscenesat af Roger Vontobel, Staatsschauspiel Dresden. Gæstespil på Kronborg Slot under Hamletscenens Shakespearefestival 1.-4. august 2015...

  11. Noble Gases in the Hamlet Meteorite (LL4)

    Science.gov (United States)

    Amari, S.; Sabe, Y.; Shiraishi, T.; Matsuda, J.

    2014-09-01

    We analyzed noble gases in a bulk sample and an HF-HCl residue of Hamlet (LL4). The Xe composition of the residue shows that no diamond is contained in the residue. The 20Ne/22Ne ratio of Hamlet Ne-Q has been determined to be 11.0 ± 0.5.

  12. Spaghetti Shakespeare: Johnny Hamlet and the Italian Western

    Directory of Open Access Journals (Sweden)

    Ciraulo Darlena

    2017-09-01

    Full Text Available The Italian Western, Johnny Hamlet (1968, directed by Enzo G. Castellari, draws on the revenge story of Shakespeare’s tragedy Hamlet for plot and characterization. While international distributors of the film downplayed its connection to highbrow Shakespeare, they emphasized the movie’s violent content and action-packed revenge narrative, which was typical of the western all’italiana. Johnny Hamlet shares similarities with the brutally violent Django (1966, directed by Sergio Corbucci, whose avenging angel protagonist epitomizes the Spaghetti Western antihero. Although the filmmakers of Johnny Hamlet characterized Johnny as a vindicator, they also sought to develop the “broody” aspect of this gunfighter, one based on Shakespeare’s famously ruminating hero. Using innovative film techniques, Johnny Hamlet shows Johnny as a contemplative pistolero.

  13. Viking stranger kings

    DEFF Research Database (Denmark)

    Dobat, Andres S.

    2015-01-01

    as a materialization of a stranger king myth, with the ship‐setting reproducing the narrative of the founding of the dynasty by an immigrant forefather, and the burial mounds conveying the idea of the foreign king taking possession of the locals’ land. In a broader erspective, the stranger king concept and the special...

  14. A New Reading of Shakespeare's Hamlet.

    Science.gov (United States)

    Usher, P. D.

    1996-12-01

    I argue that Hamlet is an allegory for the competition between the cosmological models of the contemporaries Thomas Digges (1546-1595) of England and Tycho Brahe (1546-1601) of Denmark. Through his acquaintance with the Digges' family, Shakespeare would have known of the essential elements of the revolutionary model of Nicholas Copernicus (1473-1543) as well as Digges' extension of it. Prior to 1601 when the writing of Hamlet was completed, Shakespeare knew also of Tycho and his relatives Rosencrantz and Guildenstern, and would have seen that Tycho's hybrid geocentric model was a substantial regression to the well-known geocentricism of Ptolemy (fl. 140 A.D.). It has been suggested that Polonius is named for a fictional character Pollinio, an Aristotelian pedant. I suggest that Claudius is named for Claudius Ptolemy for whom Polonius would have been a suitable attendant. I suggest further that the slaying of Rosencrantz and Guildenstern is the Bard's way of killing the Tychonic model. The slaying of Claudius signals the demise of Ptolemaic geocentricism, both ends being prolonged, the former dramatically, the latter as a matter of historical fact. But the climax of the play is not the slaughter of the chief protagonists; it is the triumphal arrival of Fortinbras from Poland and his timely salute to the ambassadors from England. By means of this apparent incongruity, Shakespeare celebrates the Copernican and Diggesian models and states poetically the nature of the new universal order. I present literary and historical evidence for the present reading which, if essentially correct, suggests that Hamlet evinces a scientific cosmology no less significant than its literary and philosophical counterparts. The last year of the sixteenth century saw the martyrdom of Bruno, but the first year of the next century saw the Bard affirm that there are more things in heaven than were dreamt of in contemporary philosophy.

  15. LEAR, shown here dismantled, will live to see another golden era as LEIR starting in 2005.

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    The LEAR (Low Energy Antiproton Ring) experiment has now been dismantled. Only the dipoles remain for use in the future LEIR (Low Energy Ion Ring) experiment, the new ring which will supply lead ions to the LHC experiments.

  16. Symposium on Highlights from 14 years of LEAR Physics : "Atomic Physics" by E. Uggerhoj

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  17. Symposium on Highlights from 14 years of LEAR Physics : "Antiproton Mass" by G. Gabrielse

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  18. Symposium on Highlights from 14 years of LEAR Physics : "CP Violation" by P. Pavlopoulos

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  19. Hamlet in Freud's Thoughts: Reinterpretations in the Psychoanalytic Literature.

    Science.gov (United States)

    Diaz de Chumaceiro, Cora L.

    1998-01-01

    Presents a selection of interpretations in the psychoanalytic literature of "Hamlet," by William Shakespeare, beginning with an extensive look at the role this literature played in Sigmund Freud's mind at the origins of psychoanalysis. Also examines later interpretations. (SR)

  20. A Sense of Worth: Seven Days with Hamlet.

    Science.gov (United States)

    Harrison, Bernard T.

    1984-01-01

    Discusses the effectiveness of a week-long teacher inservice workshop on Shakespeare's "Hamlet" in the context of an analysis of participants' responses to a 10-question evaluation of the inservice. (AEA)

  1. Knowledge, Choice and Consequence: Reading and Teaching "Hamlet."

    Science.gov (United States)

    Baumlin, James S.; Baumlin, Tita French

    1990-01-01

    Offers a Pyrrhonist reading of "Hamlet." Describes an experiment in teaching that attempts to reconstruct for literature students the prudential-ethical context of human rhetoric, placing "prudentia," or practical wisdom, at the center of their own imaginative involvement. (PRA)

  2. Harriot, Digges, and the Ghost in Hamlet.

    Science.gov (United States)

    Usher, P. D.

    1998-12-01

    The cosmic allegorical interpretation of Hamlet (BAAS 28, 1305, 1996; 29, 1262, 1997; Giornale di Astronomia 24:3, 27, 1998) may be regarded as a Galilean postulatum with testable consequences. It associates leading characters in the play with cosmologists from the time of Ptolemy (Claudius) to Tycho Brahe (Rosencrantz and Guildenstern) and Thomas Digges (Hamlet). Lines 3.3.8-23 describe how the concepts of geocentricism and the sphere of fixed stars shared by the Ptolemaic and Tychonic models are imperiled by the Infinite Universe of Digges. Hitherto baffling lines 5.2.100-125 list in short order at least 16 attributes of Thomas Harriot, including his short bibliography (``soul of great article'') which may explain why he receives mention only in passing. The Ghost is Thomas Digges' father Leonard, who is a ``mole'' in the ``cellarage.'' That Leonard may have gone underground following restoration of his lands is supported by the range of years (1559-1574) of his alleged death, and conspicuous absence of a gravesite. Circumstances of his disappearance have remained mysterious (N&Q 2:X, 162, 1860; 6:X, 368, 515, 1884; 8:V, 186, 1894.) I suggest that, having been saved from execution and restored to gentility, he continued to work, writing in the tradition of his confrere's father Thomas Wyatt, Sr. who pioneered the English sonnet. The first Dowden series of sonnets reflects his love for his only child. The history of the perspective glass explains lines in Sonnets 14 and 103 (``my blunt invention'') and in the I.M.S. encomium wherein he did ``rowle back the heavens'' with a ``cleere and equall surface'' that is ``reflecting ages past.'' A portrait of Tycho helps date Sonnet 16 to between 1581 and 1585. Sonnets 18 and 87 would date to 1583 and 1595. Allusions to old age are not surprising. I.M.'s words: ``Wee wondred (Shake-speare) that thou went'st so soone'' and ``An Actors Art, can dye, and liue to acte a second part'' are explained, as are sources for The

  3. HAMLET binding to α-actinin facilitates tumor cell detachment.

    Science.gov (United States)

    Trulsson, Maria; Yu, Hao; Gisselsson, Lennart; Chao, Yinxia; Urbano, Alexander; Aits, Sonja; Mossberg, Ann-Kristin; Svanborg, Catharina

    2011-03-08

    Cell adhesion is tightly regulated by specific molecular interactions and detachment from the extracellular matrix modifies proliferation and survival. HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a protein-lipid complex with tumoricidal activity that also triggers tumor cell detachment in vitro and in vivo, suggesting that molecular interactions defining detachment are perturbed in cancer cells. To identify such interactions, cell membrane extracts were used in Far-western blots and HAMLET was shown to bind α-actinins; major F-actin cross-linking proteins and focal adhesion constituents. Synthetic peptide mapping revealed that HAMLET binds to the N-terminal actin-binding domain as well as the integrin-binding domain of α-actinin-4. By co-immunoprecipitation of extracts from HAMLET-treated cancer cells, an interaction with α-actinin-1 and -4 was observed. Inhibition of α-actinin-1 and α-actinin-4 expression by siRNA transfection increased detachment, while α-actinin-4-GFP over-expression significantly delayed rounding up and detachment of tumor cells in response to HAMLET. In response to HAMLET, adherent tumor cells rounded up and detached, suggesting a loss of the actin cytoskeletal organization. These changes were accompanied by a reduction in β1 integrin staining and a decrease in FAK and ERK1/2 phosphorylation, consistent with a disruption of integrin-dependent cell adhesion signaling. Detachment per se did not increase cell death during the 22 hour experimental period, regardless of α-actinin-4 and α-actinin-1 expression levels but adherent cells with low α-actinin levels showed increased death in response to HAMLET. The results suggest that the interaction between HAMLET and α-actinins promotes tumor cell detachment. As α-actinins also associate with signaling molecules, cytoplasmic domains of transmembrane receptors and ion channels, additional α-actinin-dependent mechanisms are discussed.

  4. HAMLET forms annular oligomers when deposited with phospholipid monolayers.

    Science.gov (United States)

    Baumann, Anne; Gjerde, Anja Underhaug; Ying, Ming; Svanborg, Catharina; Holmsen, Holm; Glomm, Wilhelm R; Martinez, Aurora; Halskau, Oyvind

    2012-04-20

    Recently, the anticancer activity of human α-lactalbumin made lethal to tumor cells (HAMLET) has been linked to its increased membrane affinity in vitro, at neutral pH, and ability to cause leakage relative to the inactive native bovine α-lactalbumin (BLA) protein. In this study, atomic force microscopy resolved membrane distortions and annular oligomers (AOs) produced by HAMLET when deposited at neutral pH on mica together with a negatively charged lipid monolayer. BLA, BAMLET (HAMLET's bovine counterpart) and membrane-binding Peptide C, corresponding to BLA residues 75-100, also form AO-like structures under these conditions but at higher subphase concentrations than HAMLET. The N-terminal Peptide A, which binds to membranes at acidic but not at neutral pH, did not form AOs. This suggests a correlation between the capacity of the proteins/peptides to integrate into the membrane at neutral pH-as observed by liposome content leakage and circular dichroism experiments-and the formation of AOs, albeit at higher concentrations. Formation of AOs, which might be important to HAMLET's tumor toxic action, appears related to the increased tendency of the protein to populate intermediately folded states compared to the native protein, the formation of which is promoted by, but not uniquely dependent on, the oleic acid molecules associated with HAMLET. Copyright © 2012 Elsevier Ltd. All rights reserved.

  5. El Juego de Mundo en Hamlet

    OpenAIRE

    Osorio, Jorge

    2013-01-01

    A partir de una lectura de Hamlet el autor plantea la relación entre el regicidio y el desorden natural, tal como lo entendieron la filosofía política medieval y su transito a la filosofía del Renacimiento. Se indaga en el vínculo de la locura, el extravío dramático y la deriva política,  y sus implicancias en la visión  moral del mundo presente en la obra. Esta lectura teatral de la política sitúa el problema de la  dialéctica ocultación/de-velación  de los textos,  como un asunto central  d...

  6. WHEN DYLAN MET THE BARD: TRANSLATING HAMLET FROM TEXT TO SCREEN (SOUND: MICHAEL ALMEREYDA’S HAMLET

    Directory of Open Access Journals (Sweden)

    Marina Gerzic

    2015-12-01

    Full Text Available Director Michael Almereyda’s diverse musical choices in the film are a threshold into understanding his cinematic interpretation of Hamlet (2000. Almereyda recontextualises Hamlet in terms of contemporary social problems. Hamlet and Ophelia are confronted with and battle against urban claustrophobia, conspiracy and global corporate power. A fragment of the Bob Dylan song ‘All Along the Watchtower’ (1966 is used as a filmic shortcut to translate Shakespeare’s iconic ‘gravedigger scene’ between Hamlet and the Gravedigger from playtext to screen. ‘All Along the Watchtower’ encapsulates certain ideas about mortality and the worth of life from the ‘gravedigger scene’ and demonstrates these issues still resonate in the contemporary urban world the film is set.

  7. The Fifth Slovene Hamlet: Return to Tradition?

    Directory of Open Access Journals (Sweden)

    Moe Marija Zlatnar

    2017-12-01

    Full Text Available Over the nearly two centuries that Hamlet has been a fixture of the Slovene cultural firmament, the complete text has been translated five times, mostly by highly esteemed figures of Slovene literature and literary translation. This article focuses on the most recent translation, which was done by the prominent Slovene drama translator Srečko Fišer for a performance at the National Theatre in Ljubljana in 2013. It examines the new translation’s relations to its source text as well as to the previous translations. After the late twentieth century, when Hamlet was regarded as a text to be challenged, this new translation indicates the return to the tradition of reverence both for the source text and its author, and for the older translations. This is demonstrated on all levels, from the choice of source text edition, which seems to bear more similarities with the older translations than with the most recent predecessors, to the style, which echoes the solutions used by the earlier translators. Fišer continues the Slovenian tradition to a far greater extent than the two translators twenty years ago, by using the same strategies as the early translators, not fixing what was not broken, and only adding his own interpretation to the existing ones, instead of challenging or ignoring them. At the same time, however, traces of subversion of the source text can be detected, not in the form of rebellion, but rather as a mild disregard. This latest translation is the first one to frequently reshuffle the text. It is also the first to subordinate meaning to style. This all indicates that despite the apparent return to tradition, the source text is no longer treated with the reverence of the past.

  8. Kings Today, Rich Tomorrow

    DEFF Research Database (Denmark)

    Fattoum, Asma

    2013-01-01

    This study investigates the King vs. Rich dilemma that founder-CEOs face at IPO. When undertaking IPO, founders face two options. They can either get rich, but then run the risk of losing the control over their firms; or they can remain kings by introducing defensive mechanisms, but this is likel...

  9. God our king

    African Journals Online (AJOL)

    p1243322

    metaphor of king is used with a realistic claim in the Biblical texts and in the. Christian ..... love their king, whatever emotional bond there might occasionally be between them. .... green” and it would be senseless to ask what kind of power God has. It does ... attitude and behavior towards God, the focus here will be on God.

  10. The King and I

    Science.gov (United States)

    Gallagher, Mary Grace

    2009-01-01

    This year marks the 40th anniversary of the first Coretta Scott King Book Award, which encourages "the artistic expression of the black experience via literature and the graphic arts." The award, which began honoring illustrators in 1974, added the John Steptoe Award for New Talent in 1995. No doubt, past King award winners like Sharon Flake,…

  11. Hamlet's "Globe" and the Self as Performer in England and Japan

    OpenAIRE

    Shibuya, Yu

    2004-01-01

    In his paper, "Hamlet's 'Globe' and the Self as Performer in England and Japan," Yu Shibuya argues that Hamlet sees his life as a performance. Shibuya presents examples from Tsuneari Fukuda's Japanese translation to suggest that Fukuda makes choices that emphasize the theatrical side of Hamlet's character. If Hamlet perceives himself as an actor, then his definition of theater or an actor is ultimately a definition of himself. Shibuya uses the theme of self-definition to examine Kenneth Brana...

  12. Como os pintores “traduziram” Hamlet

    Directory of Open Access Journals (Sweden)

    Thais Flores Nogueira Diniz

    2015-04-01

    Full Text Available http://dx.doi.org/10.5007/2175-7968.2015v35n1p86 Textos literários sempre ofereceram terreno fértil para “traduções” em outros sistemas semióticos. As peças de Shakespeare não são uma exceção já que artistas vêm traduzindo semioticamente suas obras, principalmente para as artes visuais, e predominantemente para a pintura. Utilizando a terminologia de Benton & Butcher para classificar pinturas das peças de Shakespeare, este ensaio, analisa três imagens baseadas em Hamlet. Em seguida descreve o quadro de Daniel Maclise que se refere à “peça dentro da peça”, comparando-o com o de Edward Austin Abbey, com o mesmo tema, para demonstrar que cada obra “traduz”, à sua maneira, a ideia da culpa da personagem Gertrude.

  13. The inability to mourn and the inability to love in Shakespeare's Hamlet.

    Science.gov (United States)

    Bergmann, Martin S

    2009-04-01

    The author discusses the special role played by Shakespeare's masterpiece Hamlet in the history of psychoanalysis. Freud and many of his followers have treated Hamlet as if he were a real person inhibited by the Oedipus complex. In this presentation, Hamlet is understood as the embodiment of a brilliant artistic endeavor aimed at both revealing and concealing the power of this complex. The author proposes that, if Hamlet is autobiographical, it expresses Shakespeare's inability to mourn and love until a childhood homosexual memory has emerged. Hidden in Hamlet is a cure through the recall of a childhood memory.

  14. Lessons from the Literacy Club: Hamlet Meets the Lion King After-School

    Science.gov (United States)

    Darvin, Jacqueline

    2009-01-01

    The purpose of this article is to provide a model of an academic intervention and support program in literacy that focuses on the needs of individual students and revalues them as readers, goals that are of extreme importance when working with adolescents who have repeatedly experienced academic failure and view themselves as poor readers. This…

  15. Exploring Shakespeare through the Cinematic Image: Seeing "Hamlet."

    Science.gov (United States)

    Felter, Douglas P.

    1993-01-01

    Describes an innovative approach to teaching William Shakespeare's "Hamlet" utilizing various film versions of the play. Outlines a method of showing several versions of the same scene from different film adaptations. Describes student reaction to the variations among the different films. (HB)

  16. A Country Discovered: Upper Juniors Explore Meanings in "Hamlet."

    Science.gov (United States)

    Carter, Dennis

    1989-01-01

    Describes a project in England in which a class of 9- to 11-year olds enthusiastically and successfully explored the play "Hamlet" by writing about, discussing, performing, and visually interpreting the actual text. The teacher suggests that, with a little creativity, Shakespeare is very accessible to children. (SM)

  17. Hamlet on the Macintosh: An Experimental Seminar That Worked.

    Science.gov (United States)

    Strange, William C.

    1987-01-01

    Describes experimental college Shakespeare seminar that used Macintosh computers and software called ELIZA and ADVENTURE to develop character dialogs and adventure games based on Hamlet's characters and plots. Programming languages are examined, particularly their relationship to metaphor, and the use of computers in humanities is discussed. (LRW)

  18. IDEA: An Interdisciplinary Unit Comparing "Don Quixote" to "Hamlet."

    Science.gov (United States)

    Harris, Mary J. G.

    2001-01-01

    Describes an idea for teaching language through content-based instruction in which a high school Spanish class studying a shortened abridged version of Cervantes'"Don Quixote" and an English class reading Shakespeare's "Hamlet," did a simple comparative analysis of the two texts. (Author/VWL)

  19. "Hamlet": Something Is Tragic in the State of Denmark.

    Science.gov (United States)

    Fisher, Jessica

    This unit seeks to teach Shakespeare's "Hamlet" in a way that the students will have a full understanding of the play. The unit's introduction is designed to get the students acquainted with Shakespeare's language, to motivate them to read the play, and to make them feel confident about approaching the play. Lessons in the unit are fun,…

  20. "Hamlet" Meets "Chushingura": Traditions of the Revenge Tragedy. [Lesson Plan].

    Science.gov (United States)

    2002

    This lesson seeks to sensitize students to the similarities and difference between cultures by comparing the Shakespearean and the Bunraki/Kabuki dramas of Japan. In the lesson, the focus of this comparison is the complex nature of revenge explored in "The Tragedy of Hamlet, Prince of Denmark" and "Chusingura," or "The…

  1. Curricular Deliberation about "Hamlet": An Exercise in the Practical.

    Science.gov (United States)

    Siegel, Judith Susan

    This study attempts to clarify and exploit Joseph Schwab's recent and current work on "practical" and "eclectic" curriculums in a simulated deliberation about a concrete curricular question, How might "Hamlet" be taught to one group of high school juniors? By exemplifying curricular deliberation, it aims to clarify…

  2. Can misfolded proteins be beneficial? The HAMLET case.

    Science.gov (United States)

    Pettersson-Kastberg, Jenny; Aits, Sonja; Gustafsson, Lotta; Mossberg, Anki; Storm, Petter; Trulsson, Maria; Persson, Filip; Mok, K Hun; Svanborg, Catharina

    2009-01-01

    By changing the three-dimensional structure, a protein can attain new functions, distinct from those of the native protein. Amyloid-forming proteins are one example, in which conformational change may lead to fibril formation and, in many cases, neurodegenerative disease. We have proposed that partial unfolding provides a mechanism to generate new and useful functional variants from a given polypeptide chain. Here we present HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) as an example where partial unfolding and the incorporation of cofactor create a complex with new, beneficial properties. Native alpha-lactalbumin functions as a substrate specifier in lactose synthesis, but when partially unfolded the protein binds oleic acid and forms the tumoricidal HAMLET complex. When the properties of HAMLET were first described they were surprising, as protein folding intermediates and especially amyloid-forming protein intermediates had been regarded as toxic conformations, but since then structural studies have supported functional diversity arising from a change in fold. The properties of HAMLET suggest a mechanism of structure-function variation, which might help the limited number of human protein genes to generate sufficient structural diversity to meet the diverse functional demands of complex organisms.

  3. Hamlet's Suicide Soliloquy: A Case Study in Suicide Ideology.

    Science.gov (United States)

    Jenkins, Andrew P.

    This paper presents a secondary-level teaching technique that can be used in an integrated English and health education curriculum. The exercise provides students and teachers with a case study of a suicidal person for the purpose of teaching the warning signs of suicide, appropriate questioning, and referral skills. The case study uses Hamlet's…

  4. HAMLET: HPCN Technology for Real-Time, Embedded Applications

    NARCIS (Netherlands)

    Mager, J.W.L.J.; Dam, A. ten

    1995-01-01

    Building an application by using HPCN technology makes the solution scalable and therefore more flexible. The uptake of HPCN technology for real-time, embedded applications, however, is severely hampered by the lack of real application development support. Within the Esprit project HAMLET,

  5. "The Hound of the Baskervilles" and "Hamlet": Guide for Educators.

    Science.gov (United States)

    KIDSNET, Washington, DC.

    This study guide discusses the world premiere of two made-for-television movies of classics of English literature: "The Hound of the Baskervilles" and "Hamlet." The guide first provides a synopsis of the story of "The Hound of the Baskervilles" and gives a brief biography of the author, Sir Arthur Conan Doyle. It…

  6. The Hamlet Application Design Language: introductory definition report

    NARCIS (Netherlands)

    M.R. van Steen

    1993-01-01

    textabstractThis report provides an introduction to the definition of the Hamlet Application Design Language (ADL). ADL is a graphical-based language and notation supporting the design of parallel real-time applications. Designs expressed in ADL are based on a model of processes that communicate by

  7. Text, Style, and Author in Hamlet Q1

    Directory of Open Access Journals (Sweden)

    Christy Desmet

    2016-03-01

    Full Text Available The first quarto of Hamlet has traditionally been an embarrassment to attribution studies. Textual and bibliographical studies from the 1980s and beyond have permitted suspect texts to be recovered and performed, but critical appreciation tends to focus on such matters as characterization and performance possibilities rather than the text’s rhetorical integrity and aesthetic qualities. More recently, we have seen greater critical attention to Shakespeare’s suspect texts, which has increased our appreciation for and expanded our notion of Q1 Hamlet as a ‘text’. Opinion remains divided, however, on the question of who ‘wrote’ this play. This essay addresses the authorship debate somewhat indirectly by providing a different view of Hamlet Q1 based on a stylistic analysis that is grounded in Renaissance rhetoric. It characterizes the play’s style as the rhetoric of speed, with brachylogia as its representative rhetorical figure. Through review of theories about the composition of Hamlet Q1 and a rhetorical analysis of its style, the essay seeks to examine how Hamlet’s first quarto might have a recognizable style and how that style might be related to current concepts of authorship.

  8. From HAMLET to XAMLET: The molecular complex selectively ...

    African Journals Online (AJOL)

    HAMLET (human α-lactalbumin made lethal to tumor cells) is a complex consisting of decalcinated α-lactalbumin and oleic acid. It has been shown to induce massive cell death in various cancers without serious damage to normal tissues in both in vitro and in vivo experiments. The complexity of the mechanism in the ...

  9. Targeting of nucleotide-binding proteins by HAMLET--a conserved tumor cell death mechanism.

    Science.gov (United States)

    Ho, J C S; Nadeem, A; Rydström, A; Puthia, M; Svanborg, C

    2016-02-18

    HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) kills tumor cells broadly suggesting that conserved survival pathways are perturbed. We now identify nucleotide-binding proteins as HAMLET binding partners, accounting for about 35% of all HAMLET targets in a protein microarray comprising 8000 human proteins. Target kinases were present in all branches of the Kinome tree, including 26 tyrosine kinases, 10 tyrosine kinase-like kinases, 13 homologs of yeast sterile kinases, 4 casein kinase 1 kinases, 15 containing PKA, PKG, PKC family kinases, 15 calcium/calmodulin-dependent protein kinase kinases and 13 kinases from CDK, MAPK, GSK3, CLK families. HAMLET acted as a broad kinase inhibitor in vitro, as defined in a screen of 347 wild-type, 93 mutant, 19 atypical and 17 lipid kinases. Inhibition of phosphorylation was also detected in extracts from HAMLET-treated lung carcinoma cells. In addition, HAMLET recognized 24 Ras family proteins and bound to Ras, RasL11B and Rap1B on the cytoplasmic face of the plasma membrane. Direct cellular interactions between HAMLET and activated Ras family members including Braf were confirmed by co-immunoprecipitation. As a consequence, oncogenic Ras and Braf activity was inhibited and HAMLET and Braf inhibitors synergistically increased tumor cell death in response to HAMLET. Unlike most small molecule kinase inhibitors, HAMLET showed selectivity for tumor cells in vitro and in vivo. The results identify nucleotide-binding proteins as HAMLET targets and suggest that dysregulation of the ATPase/kinase/GTPase machinery contributes to cell death, following the initial, selective recognition of HAMLET by tumor cells. The findings thus provide a molecular basis for the conserved tumoricidal effect of HAMLET, through dysregulation of kinases and oncogenic GTPases, to which tumor cells are addicted.

  10. The Last 2000 Days: Thou shouldst not have been old till thou hadst been wise. Shakespeare (King Lear).

    Science.gov (United States)

    Cohen, Elias S

    2017-02-01

    This essay is an exploration of an extended period of the last 2000 days of anticipated mortality from the perspective of an aging gerontologist. The last 2000 days come at the end of what has come to be referred to as the Third Age (Silva, L. R. (2008). [From old age to third age: The historical course of the identities linked to the process of ageing]. História, ciências, saúde-Manguinhos, 15: , 155-168. doi:10.1590/S0104-59702008000100009). Life in the last 2000 days is a period in which the appreciation of finitude comes into new prominence, affecting a variety of elements that command attention-from individuals and from scholars. The significance of the last 2000 days is explored from two perspectives: First, the meaning, if any, of a more than half century career spent in gerontology on the personal experience of being old- how I think about my own old age, and second, an exploration of a variety of considerations that other older persons might be prompted to consider. The last 2000 days will be experienced in relatively good stages of "ability," activity, and potential engagement. This rumination explores the personal meaning of this penultimate life stage, pre-dying. It suggests some systematic consideration of what recognition of these days may mean-perception of time, identity and role, status, risks and vulnerabilities, dealing with disability, winding up/winding down/giving up, legacies, and, of course, death and dying. These issues are personal. There is no set value scale that suggests "successful aging" or "failed aging." © The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  11. King and Eye

    DEFF Research Database (Denmark)

    Suwannakij, Sing

    King and Eye explores the visual formation of kingship in Siam in its multifarious aspects. This dissertation identifies the leitmotifs in the dynamics between seeing the king and being seen by him, which burst forth in different eras. The visual sense has been a repository for the ontologization...... devices, most significantly the photographic and the cine cameras, but also encompassing other ocular apparatuses. The images produced through the contraptions were brought together under the royal eye at the apex, which in turn claimed its supremacy over space, time, and the vast and diverse population...

  12. God our king

    African Journals Online (AJOL)

    p1243322

    the “king” metaphor for God is conceptually explained in terms of the relationship ... key metaphors, then it is essential to a God-talk that is grounded in the .... Jesus are both king (cf Eph 5:5), which means that God shares his kingship with the ...

  13. Of Gods and Kings

    DEFF Research Database (Denmark)

    Brisch, Nicole

    2013-01-01

    throughout history. This is not a new point but remains all too often underappreciated when discussing the blurring of lines between human and god as evidenced in the deification of kings. In ancient Mesopotamia, one of the oldest high civilizations in the world, it was a short-lived but nevertheless...

  14. HAMLET kills tumor cells by apoptosis: structure, cellular mechanisms, and therapy.

    Science.gov (United States)

    Gustafsson, Lotta; Hallgren, Oskar; Mossberg, Ann-Kristin; Pettersson, Jenny; Fischer, Walter; Aronsson, Annika; Svanborg, Catharina

    2005-05-01

    New cancer treatments should aim to destroy tumor cells without disturbing normal tissue. HAMLET (human alpha-lactalbumin made lethal to tumor cells) offers a new molecular approach to solving this problem, because it induces apoptosis in tumor cells but leaves normal differentiated cells unaffected. After partial unfolding and binding to oleic acid, alpha-lactalbumin forms the HAMLET complex, which enters tumor cells and freezes their metabolic machinery. The cells proceed to fragment their DNA, and they disintegrate with apoptosis-like characteristics. HAMLET kills a wide range of malignant cells in vitro and maintains this activity in vivo in patients with skin papillomas. In addition, HAMLET has striking effects on human glioblastomas in a rat xenograft model. After convection-enhanced delivery, HAMLET diffuses throughout the brain, selectively killing tumor cells and controlling tumor progression without apparent tissue toxicity. HAMLET thus shows great promise as a new therapeutic with the advantage of selectivity for tumor cells and lack of toxicity.

  15. Hamlet à l’épreuve des librettistes Hamlet: Standing the Test of Librettists

    Directory of Open Access Journals (Sweden)

    Francis Guinle

    2011-12-01

    Full Text Available On ne peut pas demander à un livret l’opéra de reproduire exactement le texte de l’ouvrage dont il s’inspire. Les prétendues « faiblesses » des livrets se justifient par le fait qu’ils n’existent que pour être mis en musique. Dans quelques rares cas où le livret suit à la lettre le texte d’origine (Francis Poulenc, Dialogues des Carmélites, la musique suit le contour des mots, mais, d’ordinaire, la musique pallie le manque de poéticité des livrets. Cela paraît particulièrement le cas dans les opéras du XIXe siècle. En conséquence, il semble impossible de parler des livrets sans prendre la musique en considération. Dans le cas d’Hamlet, comment les librettistes ont-ils abordé le texte ? Où peut-on retrouver la tragédie de Shakespeare dans l’opéra d’Ambroise Thomas ? Quelle lumière l’opéra apporte-t-il sur la réception de Shakespeare au XIXe siècle ? Voilà quelques questions auxquelles cet article tentera de répondre.An opera libretto cannot be expected to reproduce the exact text of the literary or dramatic work on which it is based. The so-called “weaknesses” of the libretti may be accounted for by the fact that they are meant to be set to music. In some rare cases, where the libretto uses part of the original text (like Francis Poulenc’s Dialogues des Carmélites, the music closely follows the shape of the words, but usually it fulfills a poetical aspect lacking in the text. This seems particularly true when we consider 19th century opera. This implies that it is impossible to deal with the libretti without taking the music into account. In the case of Hamlet, what is the librettists’ approach? Where is Shakespeare’s tragedy to be found in Ambroise Thomas’s opera? What light does the opera shed on the reception of Shakespeare in the 19th century? These are the questions this article tries to answer.

  16. "Eternal Image" of Hamlet as Prototype of Intelligent Consciousness in Novel by S. Zheromsky "Homeless"

    Directory of Open Access Journals (Sweden)

    Darya B. Smirnova

    2016-12-01

    Full Text Available It is analyzed the «eternal image» of Hamlet as a prototype of the intelligentsia layer of society in the novel by S. Zheromsky «Homeless people». It is concluded that S. Zheromsky created in his novel-variation characters of Hamlet, to which the author gave national character. This relation with Hamlet manifests the motives of loneliness, homelessness and wandering.

  17. Hamlet vor Ödipus. Die Postmoderne als Mythos der Moderne

    OpenAIRE

    Zizek, Slavoj

    2001-01-01

    Wenn wir in der Psychoanalyse über Mythen sprechen, sprechen wir in Wahrheit über einen Mythos, den Ödipusmythos . alle anderen Freudschen Mythen (der des Urvaters, Freuds Version des Moses-Mythos) sind, wenn auch notwendige, Variationen davon. Mit der Hamlet Erzählung kompli­ziert sich jedoch die Lage: Die standardisierte, vor-Lacansche .naive. psychoanalytische Lesart von Hamlet fixiert sich bekanntlich auf Hamlets inzestuöses Begehren nach seiner Mutter. Hamlets Schock über den Tod sei...

  18. HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death.

    Science.gov (United States)

    Aits, Sonja; Gustafsson, Lotta; Hallgren, Oskar; Brest, Patrick; Gustafsson, Mattias; Trulsson, Maria; Mossberg, Ann-Kristin; Simon, Hans-Uwe; Mograbi, Baharia; Svanborg, Catharina

    2009-03-01

    HAMLET, a complex of partially unfolded alpha-lactalbumin and oleic acid, kills a wide range of tumor cells. Here we propose that HAMLET causes macroautophagy in tumor cells and that this contributes to their death. Cell death was accompanied by mitochondrial damage and a reduction in the level of active mTOR and HAMLET triggered extensive cytoplasmic vacuolization and the formation of double-membrane-enclosed vesicles typical of macroautophagy. In addition, HAMLET caused a change from uniform (LC3-I) to granular (LC3-II) staining in LC3-GFP-transfected cells reflecting LC3 translocation during macroautophagy, and this was blocked by the macroautophagy inhibitor 3-methyladenine. HAMLET also caused accumulation of LC3-II detected by Western blot when lysosomal degradation was inhibited suggesting that HAMLET caused an increase in autophagic flux. To determine if macroautophagy contributed to cell death, we used RNA interference against Beclin-1 and Atg5. Suppression of Beclin-1 and Atg5 improved the survival of HAMLET-treated tumor cells and inhibited the increase in granular LC3-GFP staining. The results show that HAMLET triggers macroautophagy in tumor cells and suggest that macroautophagy contributes to HAMLET-induced tumor cell death.

  19. Changes in proteasome structure and function caused by HAMLET in tumor cells.

    Science.gov (United States)

    Gustafsson, Lotta; Aits, Sonja; Onnerfjord, Patrik; Trulsson, Maria; Storm, Petter; Svanborg, Catharina

    2009-01-01

    Proteasomes control the level of endogenous unfolded proteins by degrading them in the proteolytic core. Insufficient degradation due to altered protein structure or proteasome inhibition may trigger cell death. This study examined the proteasome response to HAMLET, a partially unfolded protein-lipid complex, which is internalized by tumor cells and triggers cell death. HAMLET bound directly to isolated 20S proteasomes in vitro and in tumor cells significant co-localization of HAMLET and 20S proteasomes was detected by confocal microscopy. This interaction was confirmed by co-immunoprecipitation from extracts of HAMLET-treated tumor cells. HAMLET resisted in vitro degradation by proteasomal enzymes and degradation by intact 20S proteasomes was slow compared to fatty acid-free, partially unfolded alpha-lactalbumin. After a brief activation, HAMLET inhibited proteasome activity in vitro and in parallel a change in proteasome structure occurred, with modifications of catalytic (beta1 and beta5) and structural subunits (alpha2, alpha3, alpha6 and beta3). Proteasome inhibition was confirmed in extracts from HAMLET-treated cells and there were indications of proteasome fragmentation in HAMLET-treated cells. The results suggest that internalized HAMLET is targeted to 20S proteasomes, that the complex resists degradation, inhibits proteasome activity and perturbs proteasome structure. We speculate that perturbations of proteasome structure might contribute to the cytotoxic effects of unfolded protein complexes that invade host cells.

  20. A unifying mechanism for cancer cell death through ion channel activation by HAMLET.

    Science.gov (United States)

    Storm, Petter; Klausen, Thomas Kjaer; Trulsson, Maria; Ho C S, James; Dosnon, Marion; Westergren, Tomas; Chao, Yinxia; Rydström, Anna; Yang, Henry; Pedersen, Stine Falsig; Svanborg, Catharina

    2013-01-01

    Ion channels and ion fluxes control many aspects of tissue homeostasis. During oncogenic transformation, critical ion channel functions may be perturbed but conserved tumor specific ion fluxes remain to be defined. Here we used the tumoricidal protein-lipid complex HAMLET as a probe to identify ion fluxes involved in tumor cell death. We show that HAMLET activates a non-selective cation current, which reached a magnitude of 2.74±0.88 nA within 1.43±0.13 min from HAMLET application. Rapid ion fluxes were essential for HAMLET-induced carcinoma cell death as inhibitors (amiloride, BaCl2), preventing the changes in free cellular Na(+) and K(+) concentrations also prevented essential steps accompanying carcinoma cell death, including changes in morphology, uptake, global transcription, and MAP kinase activation. Through global transcriptional analysis and phosphorylation arrays, a strong ion flux dependent p38 MAPK response was detected and inhibition of p38 signaling delayed HAMLET-induced death. Healthy, differentiated cells were resistant to HAMLET challenge, which was accompanied by innate immunity rather than p38-activation. The results suggest, for the first time, a unifying mechanism for the initiation of HAMLET's broad and rapid lethal effect on tumor cells. These findings are particularly significant in view of HAMLET's documented therapeutic efficacy in human studies and animal models. The results also suggest that HAMLET offers a two-tiered therapeutic approach, killing cancer cells while stimulating an innate immune response in surrounding healthy tissues.

  1. hamlet, a binary genetic switch between single- and multiple- dendrite neuron morphology.

    Science.gov (United States)

    Moore, Adrian W; Jan, Lily Yeh; Jan, Yuh Nung

    2002-08-23

    The dendritic morphology of neurons determines the number and type of inputs they receive. In the Drosophila peripheral nervous system (PNS), the external sensory (ES) neurons have a single nonbranched dendrite, whereas the lineally related multidendritic (MD) neurons have extensively branched dendritic arbors. We report that hamlet is a binary genetic switch between these contrasting morphological types. In hamlet mutants, ES neurons are converted to an MD fate, whereas ectopic hamlet expression in MD precursors results in transformation of MD neurons into ES neurons. Moreover, hamlet expression induced in MD neurons undergoing dendrite outgrowth drastically reduces arbor branching.

  2. Os Simpsons em Hamlet: um petisco de Shakespeare

    Directory of Open Access Journals (Sweden)

    Robert Salem

    2014-07-01

    Full Text Available http://dx.doi.org/10.5007/2175-7968.2014v1n33p261 Este artigo se propõe a refletir sobre a adaptação de Hamlet em Os Simpsons no episódio Do the bard, man, a fim de observar aspectos importantes dessa recriação contemporânea. A releitura de Hamlet apresentada em Os Simpsons é uma peça dentro de outra, em que os personagens do seriado assumem os papéis dos personagens de Shakespeare.  O artigo enfatiza a inclusão de tantos elementos da peça de Shakespeare em uma adaptação de apenas cinco minutos e sugere uma solução de storyboard para incluir aspectos dos famosos solilóquios

  3. Shakespearean Tragedy Revisited: Death in Othello and Hamlet

    Directory of Open Access Journals (Sweden)

    Pr. Lhoussain SIMOUR

    2016-07-01

    Full Text Available This paper looks closely at death as a thematic concern in Shakespearean tragedy, with a focus on Othello and Hamlet. In both plays, death as a tragic ending brings the stories of heroes who are led up constantly to fall and yield to the force of circumstances that have been created and plotted. The calamities in Shakespeare‟s tragedies are not accidental. They proceed mainly from actions which beget others until this series of interconnected acts leads to a catastrophe. These acts are predominantly of great importance to the tragic ending. As the tragedy advances towards its „denouement‟, one would notice that the catastrophe follows inextricably from certain actions whose main source is a flaw in the hero‟s character. Such is the case with both Othello and Hamlet. This paper attempts to offer a critical reading and a discussion of Shakespeare‟s tragedy.

  4. Protein receptor-independent plasma membrane remodeling by HAMLET

    DEFF Research Database (Denmark)

    Nadeem, Aftab; Sanborn, Jeremy; Gettel, Douglas L.

    2015-01-01

    A central tenet of signal transduction in eukaryotic cells is that extra-cellular ligands activate specific cell surface receptors, which orchestrate downstream responses. This "protein-centric" view is increasingly challenged by evidence for the involvement of specialized membrane domains...... in signal transduction. Here, we propose that membrane perturbation may serve as an alternative mechanism to activate a conserved cell-death program in cancer cells. This view emerges from the extraordinary manner in which HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) kills a wide range...... of tumor cells in vitro and demonstrates therapeutic efficacy and selectivity in cancer models and clinical studies. We identify a "receptor independent" transformation of vesicular motifs in model membranes, which is paralleled by gross remodeling of tumor cell membranes. Furthermore, we find that HAMLET...

  5. Vygotsky’s Hamlet: the dialectic method and personality psychology

    OpenAIRE

    Bayanova L.F.

    2013-01-01

    This article presents an analysis of Vygotsky’s work on the psychology of art and his use of the image of Hamlet in the psychological analysis of personality. It also describes the capabilities of the dialectic method for assessing psychological problems. Reference to three dialectical oppositions—of the story and the plot, of the main character’s spinelessness and his insanity, and of subject and personality—allows the development of a theoretical analysis of the psychology of personality in...

  6. Requests for late termination of pregnancy: Tower Hamlets, 1983.

    OpenAIRE

    Savage, W

    1985-01-01

    The case histories of all women seeking late (more than 20 weeks' gestation) abortion in the NHS district of Tower Hamlets in 1983 were assessed. Of 12 women requesting late abortion, seven underwent termination of pregnancy. All the women had severe social or psychological problems, or both. The main reasons for late presentation were denial of pregnancy, youth, and mental disorder. In a small group of atypical women late abortion seems to be justified for reasons other than fetal abnormality.

  7. On the Alternative Use of Verse and Prose in Hamlet

    Institute of Scientific and Technical Information of China (English)

    李雷

    2008-01-01

    As a master in language,William Shakespeare is proficient in using verse and prose alternatively in his tragedies and comedies,which is regarded as the key to his success in literature by some critics.In this thesis,I would like to analyze the three criteria for the altemafion of verse and prose in Hamlet,in which a discussion of functions of the alternation will be included

  8. Proton - antiproton annihilations to φφ mesons: results from JETSET at LEAR

    Science.gov (United States)

    Bertolotto, L.; Buzzo, A.; Debevec, P. T.; Drijard, D.; Easo, S.; Eisenstein, R. A.; Evangelista, C.; Eyrich, W.; Fearnley, T.; Ferro-Luzzi, M.; Franz, J.; Geyer, R.; Hamann, N.; Harris, Ph.; Hertzog, D. W.; Hughes, S. A.; Johansson, T.; Jones, R.; Kilian, K.; Kirsebom, K.; Klett, A.; Korsmo, H.; Lo Vetere, M.; Marinelli, M.; Moossburger, M.; Mouëllic, B.; Oelert, W.; Ohlsson, S.; Palano, A.; Passaggio, S.; Perreau, J. M.; Pia, M. G.; Pozzo, A.; Price, M.; Reimer, P. E.; Ritter, J.; Robutti, E.; Röhrich, K.; Rook, M.; Rössle, E.; Santroni, A.; Schmitt, H.; Steinkamp, O.; Stinzing, F.; Stugu, B.; Tscheulin, M.; Urban, H. J.; Wirth, H.; Zipse, H.; Jetset Collaboration

    1993-06-01

    The πp → φφ reaction has been studied in an internal target experiment at LEAR using antiprotons at various laboratory momenta spanning the region between 1 and 2 GeV/c (cms energies between 2.08 and 2.43 GeV). Cross sections have been measured at a total of 16 different energy settings over the above range. Preliminary cross sections are reported.

  9. Proton-antiproton annihilations to [phi][phi]mesons: results from JETSET at LEAR

    Energy Technology Data Exchange (ETDEWEB)

    Bertolotto, L.; Buzzo, A.; Devevec, P.T.; Drijard, D.; Easo, S.; Eisenstein, R.A.; Evangelista, C.; Eyrich, W.; Fearnley, T.; Ferro-Luzzi, M.; Franz, J.; Geyer, R.; Hamann, N.; Harris, P.; Hertzog, D.W.; Hughes, S.A.; Johansson, T.; Jones, R.; Kilian, K.; Kirsebom, K.; Klett, A.; Korsmo, H.; Lo Vetere, M.; Marinelli, M.; Moossburger, M.; Mouellic, B.; Oelert, W.; Ohlsson, S.; Palano, A.; Passaggio, S.; Perreau, J.M.; Pia, M.G.; Pozzo, A.; Price, M.; Reimer, P.E.; Ritter, J.; Robutti, E.; Roehrich, K.; Rook, M.; Roessle, E.; Santroni, A.; Schmitt, H.; Steinkamp, O.; Stinzing, F.; Stugu, B.; Tscheulin, M.; Urban, H.J.; Wirth, H.; Zipse, H. (Istituto Nazionale di Fisica Nucleare, Genoa (Italy) Genoa Univ. (Italy) Univ. of Illinois, Urbana-Champaign (United States) European Organization for Nuclear Research (CERN), Geneva (Switzerland) Istituto Nazionale di Fisica Nucleare, Bari (Italy) Bari Univ. (Italy) Physikalisches Institut, Erlangen Univ. (Germany) Fakultaet fuer Physik, Univ. Freib; JETSET Collaboration

    1993-06-07

    The [pi]p[yields][phi][phi] reaction has been studied in an internal target experiment at LEAR using antiprotons at various laboratory momenta spanning the region between 1 and 2 GeV/c (cms energies between 2.08 and 2.43 GeV). Cross sections have been measured at a total of 16 different energy settings over the above range. Preliminary cross sections are reported. (orig.)

  10. Proton-antiproton annihilations to φφmesons: results from JETSET at LEAR

    International Nuclear Information System (INIS)

    Bertolotto, L.; Buzzo, A.; Devevec, P.T.; Drijard, D.; Easo, S.; Eisenstein, R.A.; Evangelista, C.; Eyrich, W.; Fearnley, T.; Ferro-Luzzi, M.; Franz, J.; Geyer, R.; Hamann, N.; Harris, P.; Hertzog, D.W.; Hughes, S.A.; Johansson, T.; Jones, R.; Kilian, K.; Kirsebom, K.; Klett, A.; Korsmo, H.; Lo Vetere, M.; Marinelli, M.; Moossburger, M.; Mouellic, B.; Oelert, W.; Ohlsson, S.; Palano, A.; Passaggio, S.; Perreau, J.M.; Pia, M.G.; Pozzo, A.; Price, M.; Reimer, P.E.; Ritter, J.; Robutti, E.; Roehrich, K.; Rook, M.; Roessle, E.; Santroni, A.; Schmitt, H.; Steinkamp, O.; Stinzing, F.; Stugu, B.; Tscheulin, M.; Urban, H.J.; Wirth, H.; Zipse, H.

    1993-01-01

    The πp→φφ reaction has been studied in an internal target experiment at LEAR using antiprotons at various laboratory momenta spanning the region between 1 and 2 GeV/c (cms energies between 2.08 and 2.43 GeV). Cross sections have been measured at a total of 16 different energy settings over the above range. Preliminary cross sections are reported. (orig.)

  11. Where to Be or Not to Be: The Question of Place in "Hamlet"

    Science.gov (United States)

    Golden, John

    2009-01-01

    The author does not really like "Hamlet." He loves the play, the language, and the characters, but always finds it difficult to teach. Part of this is because he prefers to assign students scenes to perform as they read a Shakespeare text, but Hamlet does not divide nicely into manageable scenes, and he usually does not have enough teenage Ken…

  12. An Analysis of the Termination of Credit Business in Faulkner's "The Hamlet"

    Science.gov (United States)

    Huang, Xiuguo

    2015-01-01

    Flem's economic reformation especially his replacement of credit business by cash business in Varner's Store in "The Hamlet" marked the social transition from a more traditional, closer and bonded community to a rather detached, rational and mechanical commercial society. The description in "The Hamlet" to a certain extent…

  13. Stability of HAMLET--a kinetically trapped alpha-lactalbumin oleic acid complex.

    Science.gov (United States)

    Fast, Jonas; Mossberg, Ann-Kristin; Svanborg, Catharina; Linse, Sara

    2005-02-01

    The stability toward thermal and urea denaturation was measured for HAMLET (human alpha-lactalbumin made lethal to tumor cells) and alpha-lactalbumin, using circular dichroism and fluorescence spectroscopy as well as differential scanning calorimetry. Under all conditions examined, HAMLET appears to have the same or lower stability than alpha-lactalbumin. The largest difference is seen for thermal denaturation of the calcium free (apo) forms, where the temperature at the transition midpoint is 15 degrees C lower for apo HAMLET than for apo alpha-lactalbumin. The difference becomes progressively smaller as the calcium concentration increases. Denaturation of HAMLET was found to be irreversible. Samples of HAMLET that have been renatured after denaturation have lost the specific biological activity toward tumor cells. Three lines of evidence indicate that HAMLET is a kinetic trap: (1) It has lower stability than alpha-lactalbumin, although it is a complex of alpha-lactalbumin and oleic acid; (2) its denaturation is irreversible and HAMLET is lost after denaturation; (3) formation of HAMLET requires a specific conversion protocol.

  14. HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53.

    Science.gov (United States)

    Hallgren, O; Gustafsson, L; Irjala, H; Selivanova, G; Orrenius, S; Svanborg, C

    2006-02-01

    HAMLET (Human alpha-lactalbumin Made Lethal to Tumor cells) triggers selective tumor cell death in vitro and limits tumor progression in vivo. Dying cells show features of apoptosis but it is not clear if the apoptotic response explains tumor cell death. This study examined the contribution of apoptosis to cell death in response to HAMLET. Apoptotic changes like caspase activation, phosphatidyl serine externalization, chromatin condensation were detected in HAMLET-treated tumor cells, but caspase inhibition or Bcl-2 over-expression did not prolong cell survival and the caspase response was Bcl-2 independent. HAMLET translocates to the nuclei and binds directly to chromatin, but the death response was unrelated to the p53 status of the tumor cells. p53 deletions or gain of function mutations did not influence the HAMLET sensitivity of tumor cells. Chromatin condensation was partly caspase dependent, but apoptosis-like marginalization of chromatin was also observed. The results show that tumor cell death in response to HAMLET is independent of caspases, p53 and Bcl-2 even though HAMLET activates an apoptotic response. The use of other cell death pathways allows HAMLET to successfully circumvent fundamental anti-apoptotic strategies that are present in many tumor cells.

  15. A parapraxis in Hamlet. A note on the aesthetic genius of William Shakespeare.

    Science.gov (United States)

    Mahon, E

    1998-01-01

    Shakespeare has placed a parapraxis in Hamlet's mouth in the soliloquy in Act I. Hamlet says, "But two months dead, nay not so much not two." The slip attributed to Hamlet is of course no slip at all when seen as an aesthetic contrivance of the bard's to suggest the tension between warring aspects of Hamlet's psychology. I argue that Shakespeare's artistic methodology, his aesthetic sleight of hand, so to speak, which layers this complex drama with meanings concealing other meanings, supports Freud's notion that an unconscious latent oedipal drama underlies the whole manifest content, imbuing it with subtle but substantial dramatic tension. The slip of the tongue is not only a window into the unconscious of Hamlet that sheds light on the hero's Oedipus complex and the complexities of his attempted resolutions, it is also an example of Shakespeare's aesthetic subtlety at its most refined.

  16. alpha-Lactalbumin species variation, HAMLET formation, and tumor cell death.

    Science.gov (United States)

    Pettersson, Jenny; Mossberg, Ann-Kristin; Svanborg, Catharina

    2006-06-23

    HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a tumoricidal complex of apo alpha-lactalbumin and oleic acid, formed in casein after low pH treatment of human milk. This study examined if HAMLET-like complexes are present in casein from different species and if isolated alpha-lactalbumin from those species can form such complexes with oleic acid. Casein from human, bovine, equine, and porcine milk was separated by ion exchange chromatography and active complexes were only found in human casein. This was not explained by alpha-lactalbumin sequence variation, as purified bovine, equine, porcine, and caprine alpha-lactalbumins formed complexes with oleic acid with biological activity similar to HAMLET. We conclude that structural variation of alpha-lactalbumins does not preclude the formation of HAMLET-like complexes and that natural HAMLET formation in casein was unique to human milk, which also showed the highest oleic acid content.

  17. The last Viking King

    DEFF Research Database (Denmark)

    Dissing, J.; Binladen, J.; Hansen, Anders J.

    2007-01-01

    of King Sven Estridsen to haplogroup H; Estrid's sequence differed from that of Sven at two positions in HVR-1, 16093T -> C and 16304T -> C, indicating that she belongs to subgroup H5a. Given the maternal inheritance of mtDNA, offspring will have the same mtDNA sequence as their mother with the exception......, there have been doubts among historians whether the woman entombed was indeed Estrid. To shed light on this problem, we have extracted and analysed mitochondrial DNA (mtDNA) from pulp of teeth from each of the two royals. Four overlapping DNA-fragments covering about 400 bp of hypervariable region 1 (HVR-1...

  18. When physics became king

    CERN Document Server

    Morus, Iwan Rhys

    2005-01-01

    As recently as two hundred years ago, physics as we know it today did not exist. Born in the early nineteenth century during the second scientific revolution, physics struggled at first to achieve legitimacy in the scientific community and culture at large. In fact, the term "physicist" did not appear in English until the 1830s.When Physics Became King traces the emergence of this revolutionary science, demonstrating how a discipline that barely existed in 1800 came to be regarded a century later as the ultimate key to unlocking nature's secrets. A cultural history designed to provid

  19. The human milk protein-lipid complex HAMLET sensitizes bacterial pathogens to traditional antimicrobial agents.

    Science.gov (United States)

    Marks, Laura R; Clementi, Emily A; Hakansson, Anders P

    2012-01-01

    The fight against antibiotic resistance is one of the most significant challenges to public health of our time. The inevitable development of resistance following the introduction of novel antibiotics has led to an urgent need for the development of new antibacterial drugs with new mechanisms of action that are not susceptible to existing resistance mechanisms. One such compound is HAMLET, a natural complex from human milk that kills Streptococcus pneumoniae (the pneumococcus) using a mechanism different from common antibiotics and is immune to resistance-development. In this study we show that sublethal concentrations of HAMLET potentiate the effect of common antibiotics (penicillins, macrolides, and aminoglycosides) against pneumococci. Using MIC assays and short-time killing assays we dramatically reduced the concentrations of antibiotics needed to kill pneumococci, especially for antibiotic-resistant strains that in the presence of HAMLET fell into the clinically sensitive range. Using a biofilm model in vitro and nasopharyngeal colonization in vivo, a combination of HAMLET and antibiotics completely eradicated both biofilms and colonization in mice of both antibiotic-sensitive and resistant strains, something each agent alone was unable to do. HAMLET-potentiation of antibiotics was partially due to increased accessibility of antibiotics to the bacteria, but relied more on calcium import and kinase activation, the same activation pathway HAMLET uses when killing pneumococci by itself. Finally, the sensitizing effect was not confined to species sensitive to HAMLET. The HAMLET-resistant respiratory species Acinetobacter baumanii and Moraxella catarrhalis were all sensitized to various classes of antibiotics in the presence of HAMLET, activating the same mechanism as in pneumococci. Combined these results suggest the presence of a conserved HAMLET-activated pathway that circumvents antibiotic resistance in bacteria. The ability to activate this pathway may extend

  20. Apariencia y realidad en Hamlet y Las Meninas

    Directory of Open Access Journals (Sweden)

    Antonio PRIETO MARTÍNEZ

    2009-11-01

    Full Text Available La obra de Shakespeare comenzó a ser estudiada en profundidad a finales del siglo XVII y, sobre todo, en el siglo XVIII. Desde ese siglo hasta el momento actual la investigación en torno a la obra shakesperiana se ha desarrollado hasta tal punto que resulta inabordable. De entre la obra de Shakespeare, Hamlet es probablemente la que suscita mayor interés a causa de su compleja estructura y su contenido ambiguo. Del mismo modo, la obra de Velázquez comenzó a estudiarse con rigor en el siglo XVIII, aunque hasta el siglo XX no se investigan sus características e influencias. Como en el caso de Shakespeare, la bibliografía existente en la actualidad sobre su obra resulta inaccesible para el investigador. De entre todas sus pinturas, Las Meninas, del mismo modo que Hamlet, es la que despierta mayor interés y tiene una proyección universal. Haciendo un recorrido por las investigaciones más importantes realizadas sobre ambas obras en los tres últimos siglos, intento encontrar semejanzas entre ellas, basándome fundamentalmente en su estructura. Apoyando mi investigación en la teoría deconstructivista, según la propuesta de J. Derrida, y siguiendo el esquema formal de ambas obras, propongo el tema general de apariencia y realidad como núcleo de sus semejanzas. Los puntos de analogía entre Hamlet y Las Meninas son, en síntesis, los siguientes: - Texto (expresado en el ser o no ser y el reverso del lienzo sobre el que pinta Velázquez. - El personaje del espectro en Hamlet y el personaje invisible en el cuadro (María Teresa de Austria o el espectador. - Velázquez significante representado en el cuadro y la obra dentro de la obra que representan los cómicos. - El personaje de Claudio, como símbolo del tirano y los reyes representados en el espejo. - Finalmente considero la vigencia y proyección que tienen ambas obras en el mundo actual.

  1. Conformational analysis of HAMLET, the folding variant of human alpha-lactalbumin associated with apoptosis.

    Science.gov (United States)

    Casbarra, Annarita; Birolo, Leila; Infusini, Giuseppe; Dal Piaz, Fabrizio; Svensson, Malin; Pucci, Piero; Svanborg, Catharina; Marino, Gennaro

    2004-05-01

    A combination of hydrogen/deuterium (H/D) exchange and limited proteolysis experiments coupled to mass spectrometry analysis was used to depict the conformation in solution of HAMLET, the folding variant of human alpha-lactalbumin, complexed to oleic acid, that induces apoptosis in tumor and immature cells. Although near- and far-UV CD and fluorescence spectroscopy were not able to discriminate between HAMLET and apo-alpha-lactalbumin, H/D exchange experiments clearly showed that they correspond to two distinct conformational states, with HAMLET incorporating a greater number of deuterium atoms than the apo and holo forms. Complementary proteolysis experiments revealed that HAMLET and apo are both accessible to proteases in the beta-domain but showed substantial differences in accessibility to proteases at specific sites. The overall results indicated that the conformational changes associated with the release of Ca2+ are not sufficient to induce the HAMLET conformation. Metal depletion might represent the first event to produce a partial unfolding in the beta-domain of alpha-lactalbumin, but some more unfolding is needed to generate the active conformation HAMLET, very likely allowing the protein to bind the C18:1 fatty acid moiety. On the basis of these data, a putative binding site of the oleic acid, which stabilizes the HAMLET conformation, is proposed.

  2. HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects.

    Science.gov (United States)

    Svanborg, Catharina; Agerstam, Helena; Aronson, Annika; Bjerkvig, Rolf; Düringer, Caroline; Fischer, Walter; Gustafsson, Lotta; Hallgren, Oskar; Leijonhuvud, Irene; Linse, Sara; Mossberg, Ann-Kristin; Nilsson, Hanna; Pettersson, Jenny; Svensson, Malin

    2003-01-01

    HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a protein-lipid complex that induces apoptosis-like death in tumor cells, but leaves fully differentiated cells unaffected. This review summarizes the information on the in vivo effects of HAMLET in patients and tumor models on the tumor cell biology, and on the molecular characteristics of the complex. HAMLET limits the progression of human glioblastomas in a xenograft model and removes skin papillomas in patients. This broad anti-tumor activity includes >40 different lymphomas and carcinomas and apoptosis is independent of p53 or bcl-2. In tumor cells HAMLET enters the cytoplasm, translocates to the perinuclear area, and enters the nuclei where it accumulates. HAMLET binds strongly to histones and disrupts the chromatin organization. In the cytoplasm, HAMLET targets ribosomes and activates caspases. The formation of HAMLET relies on the propensity of alpha-lactalbumin to alter its conformation when the strongly bound Ca2+ ion is released and the protein adopts the apo-conformation that exposes a new fatty acid binding site. Oleic acid (C18:1,9 cis) fits this site with high specificity, and stabilizes the altered protein conformation. The results illustrate how protein folding variants may be beneficial, and how their formation in peripheral tissues may depend on the folding change and the availability of the lipid cofactor. One example is the acid pH in the stomach of the breast-fed child that promotes the formation of HAMLET. This mechanism may contribute to the protective effect of breastfeeding against childhood tumors. We propose that HAMLET should be explored as a novel approach to tumor therapy.

  3. The molecular motor F-ATP synthase is targeted by the tumoricidal protein HAMLET.

    Science.gov (United States)

    Ho, James; Sielaff, Hendrik; Nadeem, Aftab; Svanborg, Catharina; Grüber, Gerhard

    2015-05-22

    HAMLET (human alpha-lactalbumin made lethal to tumor cells) interacts with multiple tumor cell compartments, affecting cell morphology, metabolism, proteasome function, chromatin structure and viability. This study investigated if these diverse effects of HAMLET might be caused, in part, by a direct effect on the ATP synthase and a resulting reduction in cellular ATP levels. A dose-dependent reduction in cellular ATP levels was detected in A549 lung carcinoma cells, and by confocal microscopy, co-localization of HAMLET with the nucleotide-binding subunits α (non-catalytic) and β (catalytic) of the energy converting F1F0 ATP synthase was detected. As shown by fluorescence correlation spectroscopy, HAMLET binds to the F1 domain of the F1F0 ATP synthase with a dissociation constant (KD) of 20.5μM. Increasing concentrations of the tumoricidal protein HAMLET added to the enzymatically active α3β3γ complex of the F-ATP synthase lowered its ATPase activity, demonstrating that HAMLET binding to the F-ATP synthase effects the catalysis of this molecular motor. Single-molecule analysis was applied to study HAMLET-α3β3γ complex interaction. Whereas the α3β3γ complex of the F-ATP synthase rotated in a counterclockwise direction with a mean rotational rate of 3.8±0.7s(-1), no rotation could be observed in the presence of bound HAMLET. Our findings suggest that direct effects of HAMLET on the F-ATP synthase may inhibit ATP-dependent cellular processes. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. HyperHamlet – Intricacies of Data Selection

    Directory of Open Access Journals (Sweden)

    Quassdorf, Sixta

    2009-01-01

    Full Text Available HyperHamlet is a database of allusions to and quotations from Shakespeare's Hamlet, which is supported by the Swiss National Science Foundation as a joint venture between the Departments of English and German Philology, and the Image & Media Lab at the University of Basel. The compilation of a corpus, whose aim it is to document the "Shakespeare phenomenon", is intricate on more than one level: the desired transdisciplinary approach between linguistics, literary and cultural studies entails data selection from a vast variety of sources; the pragmatic nature of intertextual traces, i.e. their dependence on and subordination to new contexts, further adds to formal heterogeneity. This is not only a challenge for annotation, but also for data selection. As the recognition of intertextual traces is more often than not based on intuition, this paper analyses the criteria which underlie intuition so that it can be operationalised for scholarly corpus compilation. An analogue to the pragmatic model of ostensive-inferential communication with its three constitutive parts of speaker's meaning, sentence meaning and hearer's meaning has been used for analytical heuristics. Authorial intent – in a concrete as well as in an abstract historical sense – origin and specific encyclopaedic knowledge have been found to be the basic assumptions underlying data selection, while quantitative factors provide supporting evidence.

  5. The King Tapestries at Kronborg Castle

    DEFF Research Database (Denmark)

    Reindel, Ulrik

    2015-01-01

    In the 1580s, Frederik II (Danish-Norwegian king, reigned 1559-1588) had the Great Hall at Kronborg Castle, Elsinore, furnished with 43 tapestries portraying no fewer than 100 Danish kings. The tapestries were arranged chronologically, beginning with King Dan, the mythological founder of the king...

  6. Meet EPA researcher Dawn King

    Science.gov (United States)

    Research microbiologist Dawn King works in EPA’s National Exposure Research Laboratory where she identifies and assesses the health risk of microbial pathogens in water. This is her researchers at work profile.

  7. Tests of CP Violation with $\\bar{K^0}$ and $ K^{0} $ at LEAR

    CERN Multimedia

    2002-01-01

    % PS195 Tests of CP Violation with &bar.K$^0$ and K$^0$ at LEAR \\\\ \\\\The aim of the experiment is to carry out precision tests of CP, T and CPT on the neutral kaon system through $ K ^0 - $\\bar{K}^0 $ interferometry using LEAR as an intense source. A beam of $ ~10^{6}~\\bar{p}$~events/second is brought to rest in a hydrogen target producing $ K ^0 $ and $ $\\bar{K}^0 $ events through the reaction channels : \\\\ \\\\ \\begin{center} $\\bar{p}p~~~~~\\rightarrow~~~~K^0~+~(K^-\\pi^+$) \\\\ \\\\~~~~~~~~$\\rightarrow~~~~\\bar{K}^0~+~(K^+\\pi^-$) \\end{center}\\\\ \\\\The neutral strange particles and their antiparticles are tagged by detecting in the magnetic field the sign of the accompanying charged kaons identified via Cerenkovs and scintillators. The experiment has the unique feature that the decays from particles and antiparticles are recorded under the same operating conditions using tracking chambers and a gas sampling electromagnetic calorimeter. The measured time-dependent $ K ^0 $-$ $\\bar{K}^0 $ asymmetries for non-lepton...

  8. King, Prof. Sir David Anthony

    Indian Academy of Sciences (India)

    Elected: 1998 Honorary. King, Prof. Sir David Anthony Sc.D., FRS. Date of birth: 12 August 1939. Address: Chief Scientific Adivser & Head, Office of Science and Innovation, London SW1H 0ET, U.K.. Contact: Office: (+44-020) 7215 3821. Fax: (+44-020) 7215 0314. Email: mpst.king@dti.gsi.gov.uk, dak10@cus.cam.ac.uk.

  9. Lion King Surveys Homeland

    Science.gov (United States)

    2004-01-01

    This image from the Mars Exploration Rover Opportunity's panoramic camera shows one octant of a larger panoramic image which has not yet been fully processed. The full panorama, dubbed 'Lion King' was obtained on sols 58 and 60 of the mission as the rover was perched at the lip of Eagle Crater, majestically looking down into its former home. It is the largest panorama yet obtained by either rover. The octant, which faces directly into the crater, shows features as small as a few millimeters across in the field near the rover arm, to features a few meters across or larger on the horizon. The full panoramic image was taken in eight segments using six filters per segment, for a total of 558 images and more than 75 megabytes of data. This enhanced color composite was assembled from the infrared (750 nanometer), green (530 nanometer), and violet (430 nanometer) filters. Additional lower elevation tiers were added relative to other panoramas to ensure that the entire crater was covered in the mosaic.

  10. God our king

    Directory of Open Access Journals (Sweden)

    Jan Muis

    2008-01-01

    Full Text Available This article discusses whether the metaphor of “king” can still be used in Christian God-talk. Firstly, it is argued that the “king” metaphor for God is an indispensable key metaphor in both the Old and the New Testament. “King” has become a root metaphor in the canonical text of the Old Testament and Jesus’ proclamation of the coming kingdom of God presupposes that God is king. Secondly, the Biblical meanings of the metaphor are explored. God’s kingship implies his authority and power to fight the forces of evil, to liberate and lead his people and to control the events of history. Modified by Jesus Christ, God’s kingship is universal, non-violent and in accordance with his love. Then, the use of the metaphor in contemporary God-talk is considered. Because “king” is the only metaphor that can give expression to God’s ultimate highness and authority, it cannot be replaced by others. In the concluding section the “king” metaphor for God is conceptually explained in terms of the relationship, the agency and the power of God it implies.

  11. HAMLET interacts with lipid membranes and perturbs their structure and integrity.

    Science.gov (United States)

    Mossberg, Ann-Kristin; Puchades, Maja; Halskau, Øyvind; Baumann, Anne; Lanekoff, Ingela; Chao, Yinxia; Martinez, Aurora; Svanborg, Catharina; Karlsson, Roger

    2010-02-23

    Cell membrane interactions rely on lipid bilayer constituents and molecules inserted within the membrane, including specific receptors. HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a tumoricidal complex of partially unfolded alpha-lactalbumin (HLA) and oleic acid that is internalized by tumor cells, suggesting that interactions with the phospholipid bilayer and/or specific receptors may be essential for the tumoricidal effect. This study examined whether HAMLET interacts with artificial membranes and alters membrane structure. We show by surface plasmon resonance that HAMLET binds with high affinity to surface adherent, unilamellar vesicles of lipids with varying acyl chain composition and net charge. Fluorescence imaging revealed that HAMLET accumulates in membranes of vesicles and perturbs their structure, resulting in increased membrane fluidity. Furthermore, HAMLET disrupted membrane integrity at neutral pH and physiological conditions, as shown by fluorophore leakage experiments. These effects did not occur with either native HLA or a constitutively unfolded Cys-Ala HLA mutant (rHLA(all-Ala)). HAMLET also bound to plasma membrane vesicles formed from intact tumor cells, with accumulation in certain membrane areas, but the complex was not internalized by these vesicles or by the synthetic membrane vesicles. The results illustrate the difference in membrane affinity between the fatty acid bound and fatty acid free forms of partially unfolded HLA and suggest that HAMLET engages membranes by a mechanism requiring both the protein and the fatty acid. Furthermore, HAMLET binding alters the morphology of the membrane and compromises its integrity, suggesting that membrane perturbation could be an initial step in inducing cell death.

  12. Lipids as Tumoricidal Components of Human α-Lactalbumin Made Lethal to Tumor Cells (HAMLET)

    Science.gov (United States)

    Ho, James C. S.; Storm, Petter; Rydström, Anna; Bowen, Ben; Alsin, Fredrik; Sullivan, Louise; Ambite, Inès; Mok, K. H.; Northen, Trent; Svanborg, Catharina

    2013-01-01

    Long-chain fatty acids are internalized by receptor-mediated mechanisms or receptor-independent diffusion across cytoplasmic membranes and are utilized as nutrients, building blocks, and signaling intermediates. Here we describe how the association of long-chain fatty acids to a partially unfolded, extracellular protein can alter the presentation to target cells and cellular effects. HAMLET (human α-lactalbumin made lethal to tumor cells) is a tumoricidal complex of partially unfolded α-lactalbumin and oleic acid (OA). As OA lacks independent tumoricidal activity at concentrations equimolar to HAMLET, the contribution of the lipid has been debated. We show by natural abundance 13C NMR that the lipid in HAMLET is deprotonated and by chromatography that oleate rather than oleic acid is the relevant HAMLET constituent. Compared with HAMLET, oleate (175 μm) showed weak effects on ion fluxes and gene expression. Unlike HAMLET, which causes metabolic paralysis, fatty acid metabolites were less strongly altered. The functional overlap increased with higher oleate concentrations (500 μm). Cellular responses to OA were weak or absent, suggesting that deprotonation favors cellular interactions of fatty acids. Fatty acids may thus exert some of their essential effects on host cells when in the deprotonated state and when presented in the context of a partially unfolded protein. PMID:23629662

  13. The characters God and Hamlet by Jack Miles

    Directory of Open Access Journals (Sweden)

    Tania de Fátima da Silva

    2015-04-01

    Full Text Available In the book “God - A Biography,” Jack Miles aims to introduce ourselves Creator-God as a literary character. Miles developed a narrative based on concept aristotelian, in other words, the structure of the work is made from beginning to end. This procedure established a harmony arising from the interaction between the parties, which contributes to scrutinize the precise details of the story of the main protagonist. We decided to highlight that time some characteristics of the main character of the work and compare them to the character Hamlet, by William Shakespeare, because from the beginning of the narrative to completion Miles calls the reader’s attention to the play Shakespeare.

  14. Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis.

    Science.gov (United States)

    Storm, P; Aits, S; Puthia, M K; Urbano, A; Northen, T; Powers, S; Bowen, B; Chao, Y; Reindl, W; Lee, D Y; Sullivan, N L; Zhang, J; Trulsson, M; Yang, H; Watson, J D; Svanborg, C

    2011-12-01

    HAMLET is the first member of a new family of tumoricidal protein-lipid complexes that kill cancer cells broadly, while sparing healthy, differentiated cells. Many and diverse tumor cell types are sensitive to the lethal effect, suggesting that HAMLET identifies and activates conserved death pathways in cancer cells. Here, we investigated the molecular basis for the difference in sensitivity between cancer cells and healthy cells. Using a combination of small-hairpin RNA (shRNA) inhibition, proteomic and metabolomic technology, we identified the c-Myc oncogene as one essential determinant of HAMLET sensitivity. Increased c-Myc expression levels promoted sensitivity to HAMLET and shRNA knockdown of c-Myc suppressed the lethal response, suggesting that oncogenic transformation with c-Myc creates a HAMLET-sensitive phenotype. Furthermore, HAMLET sensitivity was modified by the glycolytic state of tumor cells. Glucose deprivation sensitized tumor cells to HAMLET-induced cell death and in the shRNA screen, hexokinase 1 (HK1), 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 and hypoxia-inducible factor 1α modified HAMLET sensitivity. HK1 was shown to bind HAMLET in a protein array containing ∼8000 targets, and HK activity decreased within 15 min of HAMLET treatment, before morphological signs of tumor cell death. In parallel, HAMLET triggered rapid metabolic paralysis in carcinoma cells. Tumor cells were also shown to contain large amounts of oleic acid and its derivatives already after 15 min. The results identify HAMLET as a novel anti-cancer agent that kills tumor cells by exploiting unifying features of cancer cells such as oncogene addiction or the Warburg effect.

  15. Conserved features of cancer cells define their sensitivity of HAMLET-induced death; c-Myc and glycolysis

    Science.gov (United States)

    Storm, Petter; Puthia, Manoj Kumar; Aits, Sonja; Urbano, Alexander; Northen, Trent; Powers, Scott; Bowen, Ben; Chao, Yinxia; Reindl, Wolfgang; Lee, Do Yup; Sullivan, Nancy Liu; Zhang, Jianping; Trulsson, Maria; Yang, Henry; Watson, James; Svanborg, Catharina

    2014-01-01

    HAMLET is the first member of a new family of tumoricidal protein-lipid complexes that kill cancer cells broadly, while sparing healthy, differentiated cells. Many and diverse tumor cell types are sensitive to the lethal effect, suggesting that HAMLET identifies and activates conserved death pathways in cancer cells. Here we investigated the molecular basis for the difference in sensitivity between cancer cells and healthy cells. Using a combination of small hairpin RNA inhibition, proteomic and metabolomic technology we identified the c-Myc oncogene as one essential determinant of HAMLET sensitivity. Increased c-Myc expression levels promoted the sensitivity to HAMLET and shRNA knockdown of c-Myc suppressed the lethal response, suggesting that oncogenic transformation with c-Myc creates a HAMLET-sensitive phenotype. Furthermore, the HAMLET sensitivity was modified by the glycolytic state of the tumor cells. Glucose deprivation sensitized tumor cells to HAMLET-induced cell death and in the shRNA screen Hexokinase 1, PFKFB1 and HIF1α modified HAMLET sensitivity. Hexokinase 1 was shown to bind HAMLET in a protein array containing approximately 8000 targets and Hexokinase activity decreased within 15 minutes of HAMLET treatment, prior to morphological signs of tumor cell death. In parallel, HAMLET triggered rapid metabolic paralysis in carcinoma cells. The glycolytic machinery was modified and glycolysis was shifted towards the pentose phosphate pathway. Tumor cells were also shown to contain large amounts of oleic acid and its derivatives already after 15 minutes. The results identify HAMLET as a novel anti-cancer agent that kills tumor cells by exploiting unifying features of cancer cells such as oncogene-addiction or the Warburg effect. PMID:21643007

  16. Congratulations to Carey King

    Science.gov (United States)

    Hall, Charles A. S.

    2012-03-01

    I first came across Carey King when, out of the blue, he invited me to a special session of the annual meeting of the American Association for the Advancement of Science (the largest and most prestigious US scientific meeting) where he was developing a special session on energy return on investment (EROI). At that meeting and since, I have found Carey to be a refreshing new colleague, extremely intelligent, very knowledgeable about many diverse aspects of energy and other things, able to take criticism and to dish it out, and very ambitious, which is mostly a good thing. He is becoming a leader in thinking about EROI and its implications, and I am delighted to see him honored by Environmental Research Letters. This is important because in the US, there is little insight about energy or, especially, its potential physical limitations except when gas prices increase. There is also little awareness of the very strong historical connection in both the US and the world between increased affluence and increased use of energy, especially petroleum. It is not understood by all that many of the economic problems we have now (such as the budgetary problems faced by most of our State governments, pension plans and universities) have substantial origin in the fact that oil and other energy production no longer increase reliably year after year, as they once did (Murphy and Hall 2011). Many economists have argued in the past that energy is not important because it constituted only 5 per cent or so of GDP, or because they believe that market forces and innovations will substitute for any shortage (e.g. Barnett and Morse 1963, Passell et al 1972, Solow 1974, Denison 1989). One problem with that view is that if you remove that five per cent the economy comes to a dead stop, as Cuba found out in 1989 when Russia removed its oil subsidy. Additionally if that five per cent goes up to 10 or 15 per cent, as it did in the early 1980s, and again in 2008, recession steps in (Murphy and

  17. The Low Energy Antiproton Ring (LEAR) some months before the start of its particle physics programme

    CERN Multimedia

    1983-01-01

    LEAR*)and its enclosure in the PS South Hall in Jan, 1983, 4 months before the start of its particle physics programme. Visible (in red) are the 90 degree bending magnets consisting of 6 blocks each. Separated from the magnets by short straight sections are the quadrupole doublets (blue with read end-plates). The 4 long straight sections house large equipment like septa for injection/ejection, RF-cavities and later (since 1986) electron cooling and an internal target and its associated detector (JETSET experiment). Two small copper tubes spanning across the ring are coaxial lines transmitting the stochastic cooling signals from pickup to kicker. (see also photos 8205747X, 8207133, 8207541X, 8309026) *)see e.g.: H.Koziol and D. Möhl, Phys. Rep. 403-404 (2004), p.271 and references therein

  18. The Low Energy Antiproton Ring (LEAR) in its first year of operation

    CERN Multimedia

    1983-01-01

    LEAR*) and its enclosure in the PS South Hall in 1983 shortly after the start of its particle physics programme. Visible (in red) are the 90 degree bending magnets consisting of 6 blocks each. Separated from the magnets by short straight sections are the quadrupole doublets (blue with read end-plates). The 4 long straight sections house large equipment like septa for injection/ejection, RF-cavities and later (since 1986) electron cooling and an internal target and its associated detector (JETSET experiment). Several small copper tubes spanning across the ring are coaxial lines transmitting the stochastic cooling signals from pickup to kicker. *)[see H.Koziol and D. Möhl, Phys. Rep. 403-404 (2004), p.271 and references therein

  19. The Low Energy Antiproton Ring (LEAR) some months before the start of its particle physics programme

    CERN Multimedia

    1983-01-01

    LEAR [see e.g.: H.Koziol and D. Möhl, Phys. Rep. 403-404 (2004), p.271 and references therein] and its enclosure in the PS South Hall in Jan, 1983, 4 months before the start of its particle physics programme. Visible (in red) are the 90 degree bending magnets consisting of 6 blocks each. Separated from the magnets by short straight sections are the quadrupole doublets (blue with read end-plates). The 4 long straight sections house large equipment like septa for injection/ejection, RF-cavities and later (since 1986) electron cooling and an internal target and its associated detector (JETSET experiment). Two small copper tubes spanning across the ring are coaxial lines transmitting the stochastic cooling signals from pick up to kicker. (see also photos 8205747X, 8207133, 8207541X, 8301550X,8309026X)

  20. Recent results on lead-ion accumulation in LEAR for the LHC

    International Nuclear Information System (INIS)

    Baird, S.; Bosser, J.; Broere, J.; Carli, C.; Chanel, M.; Hill, C.; Ley, R.; Lombardi, A.; Maccaferri, R.; Maury, S.; Meshkov, I.; Moehl, D.; Molinari, G.; Mulder, H.; Syresin, E.; Tanke, E.; Tranquille, G.; Varenne, F.; Vretenar, M.

    1997-01-01

    To prepare dense bunches of lead ions for the LHC it has been proposed to accumulate the 4.2 MeV/u linac beam in a storage ring with electron cooling. A series of experiments is being performed in the low-energy ring LEAR to test this technique. First results were already reported at the Beam Crystallisation Workshop in Erice in November 1995. Two more recent runs to complement these investigations were concerned with: further study of the beam lifetime; the dependence of the cooling time on optical settings of the storage ring and on neutralization of the electron beam: and tests in view of multiturn injection. New results obtained in these two runs in December 1995 and in April 1996 are discussed in this contribution. (orig.)

  1. The fast trigger scintillator for the JETSET experiment (PS202/LEAR)

    International Nuclear Information System (INIS)

    Sefzick, T.

    1988-12-01

    In the present thesis the trigger detector of the JETSET experiment (PS202) at the LEAR/CERN consisting of scintillation counters is presented. After giving a start signal in a second stage of the trigger electronics the determination of the position of the traversed points of the reaction products is performed with the information of the scintillation detector. A third following trigger stage shall study the position informations given by the second stage under kinematical points of view. The present diploma thesis deals especially with the first two trigger stages. As basic conditions the components of a scintillation counter are treated and calibration and testing possibilities presented. For this belongs a fast light pulser with green or blue LED. Results of the studies which scintillator and light-guide materials are most suitable for the JETSET experiment are presented. (orig./HSI) [de

  2. Low resolution solution structure of HAMLET and the importance of its alpha-domains in tumoricidal activity.

    Science.gov (United States)

    Ho, C S James; Rydstrom, Anna; Manimekalai, Malathy Sony Subramanian; Svanborg, Catharina; Grüber, Gerhard

    2012-01-01

    HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is the first member in a new family of protein-lipid complexes with broad tumoricidal activity. Elucidating the molecular structure and the domains crucial for HAMLET formation is fundamental for understanding its tumoricidal function. Here we present the low-resolution solution structure of the complex of oleic acid bound HAMLET, derived from small angle X-ray scattering data. HAMLET shows a two-domain conformation with a large globular domain and an extended part of about 2.22 nm in length and 1.29 nm width. The structure has been superimposed into the related crystallographic structure of human α-lactalbumin, revealing that the major part of α-lactalbumin accommodates well in the shape of HAMLET. However, the C-terminal residues from L105 to L123 of the crystal structure of the human α-lactalbumin do not fit well into the HAMLET structure, resulting in an extended conformation in HAMLET, proposed to be required to form the tumoricidal active HAMLET complex with oleic acid. Consistent with this low resolution structure, we identified biologically active peptide epitopes in the globular as well as the extended domains of HAMLET. Peptides covering the alpha1 and alpha2 domains of the protein triggered rapid ion fluxes in the presence of sodium oleate and were internalized by tumor cells, causing rapid and sustained changes in cell morphology. The alpha peptide-oleate bound forms also triggered tumor cell death with comparable efficiency as HAMLET. In addition, shorter peptides corresponding to those domains are biologically active. These findings provide novel insights into the structural prerequisites for the dramatic effects of HAMLET on tumor cells.

  3. Views of Dr. Martin Luther King, Jr.

    Science.gov (United States)

    Davis, Alan H.

    1990-01-01

    Discusses views of Martin Luther King, Jr., including concepts of human rights, related counseling approaches, and ethics. Claims King's views provide helpful insights for counselors and clients. Concludes King invited individuals to view challenging life situations as moral opportunities. (Author/ABL)

  4. SHAKESPEARE--KING OF INFINITE SPACE.

    Science.gov (United States)

    MCCURDY, HAROLD

    CLINICAL PSYCHOLOGISTS LOOK FOR SUBSTANTIAL CONNECTIONS BETWEEN A WRITER'S LITERARY WORK AND THE EXTERNALS OF HIS LIFE, A PRACTICE THAT ENGLISH SCHOLARS ESCHEW. HOWEVER, A USEFUL KIND OF AUTOBIOGRAPHY MAY BE FOUND IN THE WORKINGS OF SHAKESPEARE'S IMAGINATION THROUGHOUT MOST OF HIS PLAYS. SHAKESPEARE, IN HAMLET'S WORDS, CAN BE CONCEIVED AS "A…

  5. Temporal changes in hamlet communities (Hypoplectrus spp., Serranidae) over 17 years.

    Science.gov (United States)

    Hench, K; Mcmillan, W O; Betancur-R, R; Puebla, O

    2017-11-01

    Transect surveys of hamlet communities (Hypoplectrus spp., Serranidae) covering 14 000 m 2 across 16 reefs off La Parguera, Puerto Rico, are presented and compared with a previous survey conducted in the year 2000. The hamlet community has noticeably changed over 17 years, with a > 30% increase in relative abundance of the yellowtail hamlet Hypoplectrus chlorurus on the inner reefs at the expense of the other hamlet species. The data also suggest that the density of H. chlorurus has declined and that its distribution has shifted towards shallower depths. Considering that H. chlorurus has been previously identified as one of the few fish showing a positive association with seawater turbidity on the inner reefs of La Parguera and that sedimentation of terrestrial origin has increased over recent decades on these reefs, it is proposed that turbidity may constitute an important but so far overlooked ecological driver of hamlet communities. © 2017 The Fisheries Society of the British Isles.

  6. Protein receptor-independent plasma membrane remodeling by HAMLET: a tumoricidal protein-lipid complex.

    Science.gov (United States)

    Nadeem, Aftab; Sanborn, Jeremy; Gettel, Douglas L; James, Ho C S; Rydström, Anna; Ngassam, Viviane N; Klausen, Thomas Kjær; Pedersen, Stine Falsig; Lam, Matti; Parikh, Atul N; Svanborg, Catharina

    2015-11-12

    A central tenet of signal transduction in eukaryotic cells is that extra-cellular ligands activate specific cell surface receptors, which orchestrate downstream responses. This ''protein-centric" view is increasingly challenged by evidence for the involvement of specialized membrane domains in signal transduction. Here, we propose that membrane perturbation may serve as an alternative mechanism to activate a conserved cell-death program in cancer cells. This view emerges from the extraordinary manner in which HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) kills a wide range of tumor cells in vitro and demonstrates therapeutic efficacy and selectivity in cancer models and clinical studies. We identify a ''receptor independent" transformation of vesicular motifs in model membranes, which is paralleled by gross remodeling of tumor cell membranes. Furthermore, we find that HAMLET accumulates within these de novo membrane conformations and define membrane blebs as cellular compartments for direct interactions of HAMLET with essential target proteins such as the Ras family of GTPases. Finally, we demonstrate lower sensitivity of healthy cell membranes to HAMLET challenge. These features suggest that HAMLET-induced curvature-dependent membrane conformations serve as surrogate receptors for initiating signal transduction cascades, ultimately leading to cell death.

  7. Oleic acid is a key cytotoxic component of HAMLET-like complexes.

    Science.gov (United States)

    Permyakov, Sergei E; Knyazeva, Ekaterina L; Khasanova, Leysan M; Fadeev, Roman S; Zhadan, Andrei P; Roche-Hakansson, Hazeline; Håkansson, Anders P; Akatov, Vladimir S; Permyakov, Eugene A

    2012-01-01

    HAMLET is a complex of α-lactalbumin (α-LA) with oleic acid (OA) that selectively kills tumor cells and Streptococcus pneumoniae. To assess the contribution of the proteinaceous component to cytotoxicity of HAMLET, OA complexes with proteins structurally and functionally distinct from α-LA were prepared. Similar to HAMLET, the OA complexes with bovine β-lactoglobulin (bLG) and pike parvalbumin (pPA) (bLG-OA-45 and pPA-OA-45, respectively) induced S. pneumoniae D39 cell death. The activation mechanisms of S. pneumoniae death for these complexes were analogous to those for HAMLET, and the cytotoxicity of the complexes increased with OA content in the preparations. The half-maximal inhibitory concentration for HEp-2 cells linearly decreased with rise in OA content in the preparations, and OA concentration in the preparations causing HEp-2 cell death was close to the cytotoxicity of OA alone. Hence, the cytotoxic action of these complexes against HEp-2 cells is induced mostly by OA. Thermal stabilization of bLG upon association with OA implies that cytotoxicity of bLG-OA-45 complex cannot be ascribed to molten globule-like conformation of the protein component. Overall, the proteinaceous component of HAMLET-like complexes studied is not a prerequisite for their activity; the cytotoxicity of these complexes is mostly due to the action of OA.

  8. Um Processador Rápido de Corte em Momento Transverso para o Trigger da Experiência CP-LEAR

    CERN Document Server

    Machado, Emanuel Tito Mendes

    Neste trabalho pretendemos mostrar alguns aspectos importantes no desenho de instrumentação para sistemas de selecção de eventos (trigger), que se revelaram importantes no desenho do sistema de trigger de CP–LEAR. Para isso, fazemos um zoom progressivo sobre a experiência. Começamos por mostrar o que são sistemas de trigger, quais as suas propriedades e diversidade, e que tipos de sistemas são usados e em que circunstâncias. É também feito um apanhado do state of the art dos diversos componentes e soluções utilizadas para a resolução dos problemas típicos destes sistemas. A seguir, apresentamos CP–LEAR, descrevendo a física em que se apoia o seu método. Aqui introduzimos o conceito de simetrias, e em que circunstâncias podemos falar de violação de simetria. Seguidamente, introduzimos o sistema de kaões neutros, apresentamos o fenómeno de violação CP, e descrevemos o método de CP–LEAR utilizado para o seu estudo. Depois de apresentar o detector utilizado na experiência, começa...

  9. [King Injo's disease and burnt needle therapy].

    Science.gov (United States)

    Kim, In-Sook

    2004-12-01

    This paper investigates an interrelationship between burnt needle therapy and King Injo's disease. From 1633 (Year 11 in King Injo's reign) to May 5, 1649 (Year 27 in King Injo's reign), right before his death, King Injo was treated with burnt needles by Yi Hyeongik, an acupuncturist when the king had health problems. This study arises from two questions: why was King Injo often treated with burnt needles? and what effect did burnt needles have?Burnt needle therapy is a combined form of acupuncture and moxibustion. Yi Hyeongik was famous for eradicating pathogenic factors. He was appointed as a doctor in the Royal Hospital. The medical definition for pathogenic factors is that they are disease-causing factors. Understanding the pathogenic factor for King Injo's disease could make it possible to find the interrelationship between burnt needles and the king's disease. In the Joseon ear, the prevalent belief about diseases was that diseases could be caused by homeopathic magic. Some people thought homeopathic magic caused King Injo's disease. The actual reasons for King Injo's disease were the participation in the excessive rites of Queen Mother Inmok's funeral and the constant oppression from the Ching Dynasty after disgraceful defeat in the war. When King Injo started to be sick, homeopathic magic cases were found in the royal palace. The king's incurable disease was believed to have happened as a result of homeopathic magic. King Injo's suspicion toward Princess Jeongmyeong derived from her mother, Queen Mother Inmok. Moral justification for King Injo's coup was Gwanghaegun or Prince Gwanghae's immoral conduct toward Queen Mothe Inmok. After he was installed, King Injo obeyed the Queen Mother and showed her every attention. Meanwhile, he treated Princess Jeongmyeong with respect, maximized the moral justification for the coup, and solidified the royal authority. However, constant rebellions and treasons threatened King Injo. The king suspected that Queen Mother

  10. King Injo's Disease and Burnt Needle Therapy

    Directory of Open Access Journals (Sweden)

    KIM In-Sook

    2004-12-01

    Full Text Available This paper investigates an interrelationship between burnt needle therapy(번침 and King Injo'sdisease. From 1633 (Year 11 in King Injo's reign to May 5, 1649 (Year 27 King in Injo's reign, right before his death, King Injo(인조 was treated with burnt needles by Yi Hyeongik(이형익, an acupuncturist when the king had health problems. This study arises from two questions: why was King Injo often treated with burnt needles? and what effect did burnt needles have? Burnt needle therapy is a combined form of acupuncture and moxibustion. Yi Hyeongik was famous for eradicating pathogenic factors. He was appointed as a doctor in the Royal Hospital. The medical definition for pathogenic factors is that they are disease-causing factors. Understanding the pathogenic factor for King Injo's disease could make it possible to find the interrelationship between burnt needles and the king's disease. In the Joseon era, the prevalent belief about diseases was that diseases could be caused by homeopathic magic. Some people thought homeopathic magic caused King Injo's disease.  The actual reasons for King Injo's disease were the participation in the excessive rites of Queen Mother Inmok's funeral and the constant oppression from the Ching Dynasty after disgraceful defeat in the war. When King Injo started to be sick, homeopathic magic cases were found in the royal palace. The king's incurable disease was believed to have happened as a result of homeopathic magic. King Injo's suspicion toward Princess Jeongmyeong(정명공주 derived from her mother, Queen Mother Inmok(인목대비. Moral justification for King Injo's coup was Gwanghaegun(광해군 or Prince Gwanghae's immoral conduct toward Queen Mother Inmok. After he was installed, King Injo obeyed the Queen Mother and showed her every attention. Meanwhile, he treated Princess Jeongmyeong with respect, maximized the moral justification for the coup, and solidified the royal authority. However, constant

  11. Women And Visual Representations Of Space In Two Chinese Film Adaptations Of Hamlet

    Directory of Open Access Journals (Sweden)

    CHEANG WAI FONG

    2014-12-01

    Full Text Available This paper studies two Chinese film adaptations of Shakespeare’s Hamlet, Xiaogang Feng’s The Banquet (2006 and Sherwood Hu’s Prince of the Himalayas (2006, by focusing on their visual representations of spaces allotted to women. Its thesis is that even though on the original Shakespearean stage details of various spaces might not be as vividly represented as in modern film productions, spaces are still crucial dramatic elements imbued with powerful significations. By analyzing the two Chinese film adaptations alongside the original Hamlet text, the paper attempts to reinterpret their different representations of spaces in relation to their different historical-cultural gender notions.

  12. The Hamlet Project in Goethe’s Wilhelm Meister’s Years of Apprenticeship

    Directory of Open Access Journals (Sweden)

    Kullmann Thomas

    2017-09-01

    – The project itself, as represented by Wilhelm, appears to be informed by a cultural movement towards emancipation from French culture: The character of Hamlet was interpreted as representing a role model for young Germans.– Informed by a theatrical practice based on French conventions, the manager objects to the lack of dramaturgical coherence of the Shakespeare play. As a compromise, Wilhelm composes an adapted version in which references to Wittenberg, Poland, France and England as well as several minor characters are cut, but the Hamlet scenes and speeches are retained.– Wilhelm and his friends also take account of German audiences’ preferences and capacities.

  13. The Tragedy of Hamlet, Son of an Organic Chemist of Denmark

    Science.gov (United States)

    Brisbois, Ronald G.

    2004-04-01

    Once faced with structure reactivity relationships in the context of nucleophilic substitution at sp 3 carbon, introductory organic chemistry students must compare and contrast the various attributes and ramifications of S N 2 versus S N 1 reaction pathways. The dramatic (even melodramatic) way in which some students ask such comparative questions inspired a parody of Hamlet's famous to be or not to be soliloquy. Herein, Hamlet (the son of an organic chemist of Denmark) is the surrogate of any and every student as he uses a thoroughly Shakespearian approach to sorting out some of the key distinguishing features of S N 2 versus S N 1 reactions.

  14. Opportunity Captures 'Lion King' Panorama

    Science.gov (United States)

    2004-01-01

    [figure removed for brevity, see original site] Click on the image for Opportunity Captures 'Lion King' Panorama (QTVR) This approximate true-color panorama, dubbed 'Lion King,' shows 'Eagle Crater' and the surrounding plains of Meridiani Planum. It was obtained by the Mars Exploration Rover Opportunity's panoramic camera on sols 58 and 60 using infrared (750-nanometer), green (530-nanometer) and blue (430-nanometer) filters. This is the largest panorama obtained yet by either rover. It was taken in eight segments using six filters per segment, for a total of 558 images and more than 75 megabytes of data. Additional lower elevation tiers were added to ensure that the entire crater was covered in the mosaic. This panorama depicts a story of exploration including the rover's lander, a thorough examination of the outcrop, a study of the soils at the near-side of the lander, a successful exit from Eagle Crater and finally the rover's next desination, the large crater dubbed 'Endurance'.

  15. EXPLORING FATHER-DAUGHTER RELATIONSHIP IN THE ABHIJNANSAKUNTALAM AND HAMLET

    Directory of Open Access Journals (Sweden)

    Dr. Naveen K. MEHTA

    2011-05-01

    Full Text Available In Shakespearian dramas, the kingly authority merges with the authority of a father. Shakespeare uses the father-daughter relationship fundamentally to discredit the practice of possession and the attitude of cupidity which was under attack in the Renaissance. During the world’s famous Indian dramatist Kalidasa period, the father was considered to be the head of the family. Kalidasa's immortal works also suggest that counsels of parents and teachers must be obeyed without any hesitation. The present paper is an attempt to explore the intricacies of the father-daughter relationship in the „Abhijnansakuntalam” and „Hamlet”, „Prince of Denmark”

  16. Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells).

    Science.gov (United States)

    Mossberg, Ann-Kristin; Wullt, Björn; Gustafsson, Lotta; Månsson, Wiking; Ljunggren, Eva; Svanborg, Catharina

    2007-09-15

    We studied if bladder cancers respond to HAMLET (human alpha-lactalbumin made lethal to tumor cells) to establish if intravesical HAMLET application might be used to selectively remove cancer cells in vivo. Patients with nonmuscle invasive transitional cell carcinomas were included. Nine patients received 5 daily intravesical instillations of HAMLET (25 mg/ml) during the week before scheduled surgery. HAMLET stimulated a rapid increase in the shedding of tumor cells into the urine, daily, during the 5 days of instillation. The effect was specific for HAMLET, as intravesical instillation of NaCl, PBS or native alpha-lactalbumin did not increase cell shedding. Most of the shed cells were dead and an apoptotic response was detected in 6 of 9 patients, using the TUNEL assay. At surgery, morphological changes in the exophytic tumors were documented by endoscopic photography and a reduction in tumor size or change in tumor character was detected in 8 of 9 patients. TUNEL staining was positive in biopsies from the remaining tumor in 4 patients but adjacent healthy tissue showed no evidence of apoptosis and no toxic response. The results suggest that HAMLET exerts a direct and selective effect on bladder cancer tissue in vivo and that local HAMLET administration might be of value in the future treatment of bladder cancers. (c) 2007 Wiley-Liss, Inc.

  17. Structure and function of human α-lactalbumin made lethal to tumor cells (HAMLET)-type complexes.

    Science.gov (United States)

    Mossberg, Ann-Kristin; Hun Mok, Kenneth; Morozova-Roche, Ludmilla A; Svanborg, Catharina

    2010-11-01

    Human α-lactalbumin made lethal to tumor cells (HAMLET) and equine lysozyme with oleic acid (ELOA) are complexes consisting of protein and fatty acid that exhibit cytotoxic activities, drastically differing from the activity of their respective proteinaceous compounds. Since the discovery of HAMLET in the 1990s, a wealth of information has been accumulated, illuminating the structural, functional and therapeutic properties of protein complexes with oleic acid, which is summarized in this review. In vitro, both HAMLET and ELOA are produced by using ion-exchange columns preconditioned with oleic acid. However, the complex of human α-lactalbumin with oleic acid with the antitumor activity of HAMLET was found to be naturally present in the acidic fraction of human milk, where it was discovered by serendipity. Structural studies have shown that α-lactalbumin in HAMLET and lysozyme in ELOA are partially unfolded, 'molten-globule'-like, thereby rendering the complexes dynamic and in conformational exchange. HAMLET exists in the monomeric form, whereas ELOA mostly exists as oligomers and the fatty acid stoichiometry varies, with HAMLET holding an average of approximately five oleic acid molecules, whereas ELOA contains a considerably larger number (11- 48). Potent tumoricidal activity is found in both HAMLET and ELOA, and HAMLET has also shown strong potential as an antitumor drug in different in vivo animal models and clinical studies. The gain of new, beneficial function upon partial protein unfolding and fatty acid binding is a remarkable phenomenon, and may reflect a significant generic route of functional diversification of proteins via varying their conformational states and associated ligands. © 2010 The Authors Journal compilation © 2010 FEBS.

  18. Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells).

    Science.gov (United States)

    Hallgren, Oskar; Aits, Sonja; Brest, Patrick; Gustafsson, Lotta; Mossberg, Ann-Kristin; Wullt, Björn; Svanborg, Catharina

    2008-01-01

    HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a molecular complex derived from human milk that kills tumor cells by a process resembling programmed cell death. The complex consists of partially unfolded alpha-lactalbumin and oleic acid, and both the protein and the fatty acid are required for cell death. HAMLET has broad antitumor activity in vitro, and its therapeutic effect has been confirmed in vivo in a human glioblastoma rat xenograft model, in patients with skin papillomas and in patients with bladder cancer. The mechanisms of tumor cell death remain unclear, however. Immediately after the encounter with tumor cells, HAMLET invades the cells and causes mitochondrial membrane depolarization, cytochrome c release, phosphatidyl serine exposure, and a low caspase response. A fraction of the cells undergoes morphological changes characteristic of apoptosis, but caspase inhibition does not rescue the cells and Bcl-2 overexpression or altered p53 status does not influence the sensitivity of tumor cells to HAMLET. HAMLET also creates a state of unfolded protein overload and activates 20S proteasomes, which contributes to cell death. In parallel, HAMLET translocates to tumor cell nuclei, where high-affinity interactions with histones cause chromatin disruption, loss of transcription, and nuclear condensation. The dying cells also show morphological changes compatible with macroautophagy, and recent studies indicate that macroautophagy is involved in the cell death response to HAMLET. The results suggest that HAMLET, like a hydra with many heads, may interact with several crucial cellular organelles, thereby activating several forms of cell death, in parallel. This complexity might underlie the rapid death response of tumor cells and the broad antitumor activity of HAMLET.

  19. Prevention and treatment of colon cancer by peroral administration of HAMLET (human α-lactalbumin made lethal to tumour cells).

    Science.gov (United States)

    Puthia, Manoj; Storm, Petter; Nadeem, Aftab; Hsiung, Sabrina; Svanborg, Catharina

    2014-01-01

    Most colon cancers start with dysregulated Wnt/β-catenin signalling and remain a major therapeutic challenge. Examining whether HAMLET (human α-lactalbumin made lethal to tumour cells) may be used for colon cancer treatment is logical, based on the properties of the complex and its biological context. To investigate if HAMLET can be used for colon cancer treatment and prevention. Apc(Min)(/+) mice, which carry mutations relevant to hereditary and sporadic human colorectal tumours, were used as a model for human disease. HAMLET was given perorally in therapeutic and prophylactic regimens. Tumour burden and animal survival of HAMLET-treated and sham-fed mice were compared. Tissue analysis focused on Wnt/β-catenin signalling, proliferation markers and gene expression, using microarrays, immunoblotting, immunohistochemistry and ELISA. Confocal microscopy, reporter assay, immunoprecipitation, immunoblotting, ion flux assays and holographic imaging were used to determine effects on colon cancer cells. Peroral HAMLET administration reduced tumour progression and mortality in Apc(Min)(/+) mice. HAMLET accumulated specifically in tumour tissue, reduced β-catenin and related tumour markers. Gene expression analysis detected inhibition of Wnt signalling and a shift to a more differentiated phenotype. In colon cancer cells with APC mutations, HAMLET altered β-catenin integrity and localisation through an ion channel-dependent pathway, defining a new mechanism for controlling β-catenin signalling. Remarkably, supplying HAMLET to the drinking water from the time of weaning also significantly prevented tumour development. These data identify HAMLET as a new, peroral agent for colon cancer prevention and treatment, especially needed in people carrying APC mutations, where colon cancer remains a leading cause of death.

  20. Hamlet - little known piece by Enriko Josif: Literary-theoretical, philosophical and musicological views

    Directory of Open Access Journals (Sweden)

    Marjanović Nataša

    2011-01-01

    Full Text Available Hamlet is well-known as the most famous tragedy written by William Shakespeare. This dramatic work has, throughout the centuries, lead numerous writers, poets, literary-critics and philosophers to think about universal issues of life, human nature, love, loyalty and friendship. Hamlet has not just been the subject of discussion from the point of view of the theory of literature and human psychology and philosophy, it has also directly inspired the creation of many artistic works. One of those works which forms the main subject-matter of this paper is the almost unknown music for Hamlet by Enriko Josif. Enriko Josif was an extraordinary figure, a versatile artist and thinker, almost a kind of philosopher. In his opinion and in accordance with his inner feeling, art was a matter of divine creation first of all. He admired those artists who dealt with difficult issues of life in their works of art and William Shakespeare was to him one of the most prominent among them. In general terms, we have highlighted certain general points about Josif’s views on an artist’s life and work and have presented our notions about his piece. Specifically, we have tried to point out personal views that Josif held about Hamlet, as well as the most important features of Josif’s music, which are broadly in accordance with the literary, ethical, philosophical and theological critical tradition surrounding this masterpiece.

  1. Hip-Hop Hamlet: Hybrid Interpretive Discourse in a Suburban High School English Class

    Science.gov (United States)

    Anglin, Joanna L.; Smagorinsky, Peter

    2014-01-01

    This study investigates the collaborative composing processes of a group of five high school seniors who constructed interpretations of each of the five acts of Shakespeare's Hamlet through the medium of spoken word performances. The group composing processes were analyzed to identify how the students drew on conventions from the spoken word…

  2. Constructing Knowledge from an Ill-Structured Domain: Testing a Multimedia Hamlet.

    Science.gov (United States)

    Barnes, William G. W.

    How a multimedia program that employs concept maps and hypertext for teaching "Hamlet" facilitated comprehension in an undergraduate course is described. Results suggest factors that instructional designers should take into account to improve learning. Thirty-six upper-division college students were enrolled in a course on Shakespeare at…

  3. "Hamlet" and the Elizabethan Revenge Ethic in Text and Film. [Lesson Plan].

    Science.gov (United States)

    2002

    This lesson seeks to sensitize students to the complex nature of revenge as it is portrayed in William Shakespeare's "The Tragedy of Hamlet, Prince of Denmark." In the lesson, students learn how Shakespeare's play interprets Elizabethan attitudes toward revenge, as reflected in the structure of the Elizabethan revenge tragedy, one of the…

  4. An Analysis of Ophelia in Hamlet from the Perspective of Feminist Care Ethic

    Institute of Scientific and Technical Information of China (English)

    张洁

    2015-01-01

    Through the ages,Ophelia in Hamlet has long been regarded as a childish maid.This thesis will give an analysis of Ophelia's growth from the perspective of feminist care ethic developmental stages theory,trying to illustrate that in the play Ophelia has experienced ethical development and has arrived at ethical maturity in the end.

  5. Ecological wisdom of Hindu-Javanese community settlement in Cetho Hamlet, Lawu Mountains, Central Java, Indonesia

    Science.gov (United States)

    Ikhsan, Fauzan Ali; Setioko, Bambang; Suprapti, Atiek

    2017-12-01

    Dwelling culture of Java community has a long history. In Javanese community point of view, Javanese culture is not a homogeneous entity. There is a diversity characteristic of a regional nature of Javanese culture, which is caused by differences in the natural environment on the island of Java. Dwelling Culture settled in the mountains is a variant form of Javanese culture that has its own uniqueness. This study aimed to describe the local values of the rural settlement structure of in Lawu mountains with Hindu-Javanese culture background. This study used a qualitative approach with case study strategy. The locus of research is in the Cetho hamlet on the slopes of Mount Lawu Karanganyar, Central Java. The results showed that local values in the neighborhoods of Cetho hamlet is based on the Memayu Hayuning Bawana philosophy. These concepts are abstracted into various aspects of settlements in Cetho hamlet such as aspects of dwelling house setting, water management, and ritual activities related to environmental management. Memayu Hayuning Bawana philosophy becomes a cultural space coloring the ecological action of the population of Cetho hamlet. The comprehensive motivation of ecological action ultimately leads to one final goal, namely the desire to maintain a harmonic atmosphere with the surroundings.

  6. Does Hamlet Belong in Freshman Composition? The Debatable Role of Canonical Literature in Composition

    Science.gov (United States)

    Fitzwilliam, Marie A.

    2006-01-01

    The question of whether "Hamlet" belongs in a freshman composition classroom is one that institutions are making easier to answer, though perhaps for political rather than pedagogical reasons. This article describes a project in which Marie Fitzwilliam and her colleagues were asked to engage in a dialogue with the administration on…

  7. The Hamlet design entry system: on the implementation of synchronous channels

    NARCIS (Netherlands)

    M.R. van Steen

    1994-01-01

    textabstractThe graphical Hamlet Application Design Language (ADL) has been developed to support the construction of parallel applications. The language is based on a notion of processes communicating by means of message-passing. One of the goals of ADL is that its implementation should allow

  8. "To be or not to be" - Hamlets monolog i danske oversættelser

    DEFF Research Database (Denmark)

    Onsberg, Merete

    2008-01-01

    Tolv danske oversættelser af Hamlets monolog To be or not to be fra 1807 til i dag undersøges metrisk for at give et signalement af blankverset på dansk. Der argumenteres for at opfatte det danske blankvers som bisyllabiske femslagsrækker med fire slag og trisyllabler som variationer, hvorimod...

  9. Disjointed Confessions: Adikia and Radical Deradicalization in Schlingensief’s Hamlet

    Directory of Open Access Journals (Sweden)

    Janus C. Currie

    2017-01-01

    Full Text Available In 2001, in Zürich Switzerland, German director Christoph Schlingensief staged a version of Shakespeare’s Hamlet. In this version’s famous mousetrap scene, in which Hamlet wants to force his uncle to confess to fratricide, all the players of the mise en abyme are portrayed by a group of neo-Nazis endeavouring to separate themselves from the right–wing scene. In a dramatic break from Shakespeare’s text the group go on to share their own personal experiences with the audience. The production attempted to comment on and create debate about the ‘rottenness’ of the State, not just Switzerland, amid the rise in approval ratings and growing influence of far-right parties in the surrounding countries. I posit that Schlingensief’s project is a form of radical deradicalization (i.e., a radical method of deradicalizing neo-Nazis. This paper analyses Schlingensief’s Hamlet by utilizing the concepts of adikia (disjointure, dislocation, injustice and dike (jointure, ordering, justice, which go back to the oldest extant Greek text: the Anaximander fragment. Drawing on Martin Heidegger and Jacques Derrida’s reinterpretations of adikia and dike I endeavour to illustrate how Schlingensief’s work attempts to intervene in the disjointure caused by the contemporary politics of fear by bringing adikia to the production of Hamlet itself.

  10. The "Strange Alteration" of "Hamlet": Comic Books, Adaptation and Constructions of Adolescent Literacy

    Science.gov (United States)

    Sabeti, Shari

    2014-01-01

    This article examines two comic book adaptations of Shakespeare's "Hamlet" produced for teenage readers and used in school classrooms. It seeks to understand the ways in which particular kinds of literacy are being implied and constructed through the textual practice of multimodal adaptation. It presents a close reading of sections of…

  11. The Words of Martin Luther King, Jr.

    Science.gov (United States)

    Today's Education, 1979

    1979-01-01

    Excerpts from speeches by Dr. Martin Luther King, Jr., are reprinted. Topics discussed include discrimination, the South, education, nonviolent resistance, poverty, economic opportunity, and world peace. (LH)

  12. The True Lion King of Africa: The Epic History of Sundiata, King of Old Mali.

    Science.gov (United States)

    Paterno, Domenica R.

    David Wisniewski's 1992 picture book version of the African epic of "Sundiata, Lion King of Mali" and the actual historical account of the 13th century Lion King, Sundiata, are both badly served by Disney's "The Lion King." Disney has been praised for using African animals as story characters; for using the African landscape as…

  13. TO ACT OR NOT TO ACT: HOW COLERIDGE CHANGED THE WAY WE SEE "HAMLET"

    Directory of Open Access Journals (Sweden)

    Svetozar Poštić

    2014-10-01

    Full Text Available Exactly 200 years ago, from 1811 to 1819, Samuel Taylor Coleridge, one of the most famous English Romantic poets, held a series of influential lectures about William Shakespeare and his plays. His presentation of "Hamlet", a play hitherto not only negatively appraised, but even viewed quite negatively by the leading critics, most notably Samuel Johnson, was especially significant. His insightful analysis helped to change the general opinion about the play, and pointed to the qualities of "Hamlet" that made it into perhaps the best known and most frequently played drama in the next 200 years. In this paper, I examine the way Coleridge was able to recognize the neglected features of Shakespeare’s profound tragedy up to that point. First of all, he identified with the main protagonist of the play, the Prince of Denmark, and described the unbridgeable gap between ambitions and power of imagination on the one hand, and inability to act on the other. Like Hamlet, Coleridge had "great, enormous, intellectual activity, and a consequent proportionate aversion to real action" (Coleridge 2014: 345. Aware of this shortcoming, but unable to correct it, the extremely talented and educated Coleridge presented it in fascinating detail. Secondly, he used his knowledge of the most influential contemporary philosophers, especially Kant, Locke and Hobbes, and the increasingly popular psychological approach to character analysis in order to paint an internal portrait of leading characters of the play. Due to the increasingly popular trend in recent literary theory and analysis focusing on the political and material context of an art work, the universal qualities of Coleridge's intepretation of "Hamlet" that contributed to the lasting influence of his critique have been largely neglected. This article intends, therefore, to re-establish the significance of Coleridge's "Hamlet" lectures.

  14. Professor Walter Oelert, leader of the team which created the first atoms of antihydrogen at the Low Energy Antiproton Ring (LEAR) in January 1996

    CERN Document Server

    Laurent Guiraud

    1996-01-01

    Antiparticles were predicted in the work of Paul Dirac in the 1920's, since when physicists have identified all the necessary antiparticle constituents of an antiparticle atom - antielectrons (positrons), antiprotons and antineutrons. However, an antihydrogen atom wasn't produced until the PS210 experiment at CERN in 1995. PS210 used the LEAR accelerator, which was then nearing the end of its lifetime, so everything in the experiment had to work first time. After installing the equipment in spring 1995, the experiment took place in the autumn, in two hour periods over 4 weeks. The experiment team collided energetic antiprotons from LEAR with a heavy element, a challenge for them as well as the LEAR operators. Proving that antihydrogen atoms had been formed required several more weeks of data analysis, but the announcement that nine antihydrogen atoms had been produced came on 4 January 1996.

  15. Empowerment Of Position And Roles Of Traditional Leaders In The Development Of Livestock Hamlet In The Banten Province

    Directory of Open Access Journals (Sweden)

    Kedi Suradisastr

    2011-06-01

    Full Text Available Developing livestock village is a suitable effort to enhance meat production for fulfilling increasing of the product demand. Developing livestock village in form of Sheep Hamlet in the Regency of Pandeglang, Province of Banten, is also function as forest and environmental buffer zone. Another target of such a livestock development center is to improve farmer’s income by at least 50% of Banten’s Minimum Regional Wage. The success of Sheep Hamlet so far depends upon the following socio-cultural factors: (a the basic culture of the Bantams, (b local leadership, and (c decision making pattern and process. The development of livestock hamlet depends on the roles of local informal figure in the respective area. Such a local leader can help accelerating the success of a livestock development in a sustainable fashion. The existence of a respected local figure is a crucial entry point in the process of livestock hamlet development in the such area.

  16. Investigation of the anti pp → xi (2220) → K/sub s/K/sub s/ reaction at LEAR

    International Nuclear Information System (INIS)

    Hertzog, D.W.

    1985-01-01

    Measurement of the total and differential cross section of the reaction anti pp → K/sub s/K/sub s/ in a fine momentum scan corresponding to the mass range of the xi (2220) was proposed. The mass and width of such a resonance coupling to anti pp can be determined to better than 500 keV and additionally the spin can be established from the differential cross section. Only modest additions to our existing threshold detector and antiproton beam intensities currently available at LEAR are required for these studies. 14 refs

  17. Structure and Potential Cellular Targets of HAMLET-like Anti-Cancer Compounds made from Milk Components.

    Science.gov (United States)

    Rath, Emma M; Duff, Anthony P; Håkansson, Anders P; Vacher, Catherine S; Liu, Guo Jun; Knott, Robert B; Church, William Bret

    2015-01-01

    The HAMLET family of compounds (Human Alpha-lactalbumin Made Lethal to Tumours) was discovered during studies on the properties of human milk, and is a class of protein-lipid complexes having broad spectrum anti-cancer, and some specific anti-bacterial properties. The structure of HAMLET-like compounds consists of an aggregation of partially unfolded protein making up the majority of the compound's mass, with fatty acid molecules bound in the hydrophobic core. This is a novel protein-lipid structure and has only recently been derived by small-angle X-ray scattering analysis. The structure is the basis of a novel cytotoxicity mechanism responsible for anti-cancer activity to all of the around 50 different cancer cell types for which the HAMLET family has been trialled. Multiple cytotoxic mechanisms have been hypothesised for the HAMLET-like compounds, but it is not yet clear which of those are the initiating cytotoxic mechanism(s) and which are subsequent activities triggered by the initiating mechanism(s). In addition to the studies into the structure of these compounds, this review presents the state of knowledge of the anti-cancer aspects of HAMLET-like compounds, the HAMLET-induced cytotoxic activities to cancer and non-cancer cells, and the several prospective cell membrane and intracellular targets of the HAMLET family. The emerging picture is that HAMLET-like compounds initiate their cytotoxic effects on what may be a cancer-specific target in the cell membrane that has yet to be identified. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

  18. 75 FR 34307 - King Kamehameha Day, 2010

    Science.gov (United States)

    2010-06-16

    ... Kamehameha Day, 2010 By the President of the United States of America A Proclamation Two hundred years ago, King Kamehameha the Great brought the Hawaiian Islands together under a unified government. His courage...'s concern for public safety.'' On this bicentennial King Kamehameha Day, we celebrate the history...

  19. The King's Ring: A Matter of Trust

    DEFF Research Database (Denmark)

    Sterrett, Joseph William

    2018-01-01

    This essay examines the material and social effects of an exchange of trust between a king, Henry VIII, and his counsellor, Thomas Cranmer in Shakespeare and Fletcher’s All is True. The ring that the King gives Cranmer is both nothing and everything: nothing in that it could be anything, any ring...

  20. Sensitization of Staphylococcus aureus to methicillin and other antibiotics in vitro and in vivo in the presence of HAMLET.

    Directory of Open Access Journals (Sweden)

    Laura R Marks

    Full Text Available HAMLET (human alpha-lactalbumin made lethal to tumor cells is a protein-lipid complex from human milk with both tumoricidal and bactericidal activities. HAMLET exerts a rather specific bactericidal activity against some respiratory pathogens, with highest activity against Streptococcus pneumoniae, but lacks activity against most other bacterial pathogens, including Staphylococci. Still, ion transport associated with death in S. pneumoniae is also detected to a lower degree in insensitive organisms. In this study we demonstrate that HAMLET acts as an antimicrobial adjuvant that can increase the activity of a broad spectrum of antibiotics (methicillin, vancomycin, gentamicin and erythromycin against multi-drug resistant Staphylococcus aureus, to a degree where they become sensitive to those same antibiotics, both in antimicrobial assays against planktonic and biofilm bacteria and in an in vivo model of nasopharyngeal colonization. We show that HAMLET exerts these effects specifically by dissipating the proton gradient and inducing a sodium-dependent calcium influx that partially depolarizes the plasma membrane, the same mechanism induced during pneumococcal death. These effects results in an increased cell associated binding and/or uptake of penicillin, gentamicin and vancomycin, especially in resistant stains. Finally, HAMLET inhibits the increased resistance of methicillin seen under antibiotic pressure and the bacteria do not become resistant to the adjuvant, which is a major advantageous feature of the molecule. These results highlight HAMLET as a novel antimicrobial adjuvant with the potential to increase the clinical usefulness of antibiotics against drug resistant strains of S. aureus.

  1. Sensitization of Staphylococcus aureus to methicillin and other antibiotics in vitro and in vivo in the presence of HAMLET.

    Science.gov (United States)

    Marks, Laura R; Clementi, Emily A; Hakansson, Anders P

    2013-01-01

    HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a protein-lipid complex from human milk with both tumoricidal and bactericidal activities. HAMLET exerts a rather specific bactericidal activity against some respiratory pathogens, with highest activity against Streptococcus pneumoniae, but lacks activity against most other bacterial pathogens, including Staphylococci. Still, ion transport associated with death in S. pneumoniae is also detected to a lower degree in insensitive organisms. In this study we demonstrate that HAMLET acts as an antimicrobial adjuvant that can increase the activity of a broad spectrum of antibiotics (methicillin, vancomycin, gentamicin and erythromycin) against multi-drug resistant Staphylococcus aureus, to a degree where they become sensitive to those same antibiotics, both in antimicrobial assays against planktonic and biofilm bacteria and in an in vivo model of nasopharyngeal colonization. We show that HAMLET exerts these effects specifically by dissipating the proton gradient and inducing a sodium-dependent calcium influx that partially depolarizes the plasma membrane, the same mechanism induced during pneumococcal death. These effects results in an increased cell associated binding and/or uptake of penicillin, gentamicin and vancomycin, especially in resistant stains. Finally, HAMLET inhibits the increased resistance of methicillin seen under antibiotic pressure and the bacteria do not become resistant to the adjuvant, which is a major advantageous feature of the molecule. These results highlight HAMLET as a novel antimicrobial adjuvant with the potential to increase the clinical usefulness of antibiotics against drug resistant strains of S. aureus.

  2. Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification.

    Science.gov (United States)

    Moore, Adrian W; Roegiers, Fabrice; Jan, Lily Y; Jan, Yuh-Nung

    2004-03-15

    The Drosophila external sensory organ forms in a lineage elaborating from a single precursor cell via a stereotypical series of asymmetric divisions. HAMLET transcription factor expression demarcates the lineage branch that generates two internal cell types, the external sensory neuron and thecogen. In HAMLET mutant organs, these internal cells are converted to external cells via an unprecedented cousin-cousin cell-fate respecification event. Conversely, ectopic HAMLET expression in the external cell branch leads to internal cell production. The fate-determining signals NOTCH and PAX2 act at multiple stages of lineage elaboration and HAMLET acts to modulate their activity in a branch-specific manner.

  3. Heterothermy in growing king penguins.

    Science.gov (United States)

    Eichhorn, Götz; Groscolas, René; Le Glaunec, Gaële; Parisel, Camille; Arnold, Laurent; Medina, Patrice; Handrich, Yves

    2011-08-16

    A drop in body temperature allows significant energy savings in endotherms, but facultative heterothermy is usually restricted to small animals. Here we report that king penguin chicks (Aptenodytes patagonicus), which are able to fast for up to 5 months in winter, undergo marked seasonal heterothermy during this period of general food scarcity and slow-down of growth. They also experience short-term heterothermy below 20 °C in the lower abdomen during the intense (re)feeding period in spring, induced by cold meals and adverse weather. The heterothermic response involves reductions in peripheral temperature, reductions in thermal core volume and temporal abandonment of high core temperature. Among climate variables, air temperature and wind speed show the strongest effect on body temperature, but their effect size depends on physiological state. The observed heterothermy is remarkable for such a large bird (10 kg before fasting), which may account for its unrivalled fasting capacity among birds.

  4. "To Thine Own Self Be True": Existentialism in Hamlet and The Blind Owl

    Directory of Open Access Journals (Sweden)

    Masoud Farahmandfar

    2015-04-01

    Full Text Available This article aims at exploring the key concepts of Existential thought in two masterpieces of the world literature, namely, William Shakespeare’s Hamlet and Sadeq Hedayat’s The Blind Owl (Buf-e Kur. Freedom, free will, authenticity, self-realization, self-becoming, and awareness of death are among the main concerns of both writers. Shakespeare depicts authenticity in the character of Hamlet, and it is in contrast to him that the reader finds many instances of inauthenticity. The Danish prince has no tolerance whatsoever for inauthentic or self-deceiving. The same thing is visible in The Blind Owl in which the narrator-protagonist feels himself above all the low, petty desires of mankind. All in all, both characters’ main challenge is to live authentically. Keywords: Existential philosophy, authenticity, angst, death, being, existence, self-realization

  5. Interweaving Stories. Hamlet in Jerusalem by Gabriele Vacis and Marco Paolini

    Directory of Open Access Journals (Sweden)

    Franco Nasi

    2017-12-01

    Full Text Available In march 2016, playwright and director Gabriele Vacis, together with Marco Paolini and a group of young Palestinian and Italian actors staged Amleto in Jerusalem, the last production of a “school of theater” for adolescents, directed by Vacis and Paolini. Moving from a brief introduction to the pedagogical and aesthetic philosophy that inspired this educational experience, this article offers a critical description of the structurally complex performance, in which two different theatrical genres, storytelling and tragedy, are continuously intermingled.  In the performance the text by Shakespeare is revisited, deconstructed,  and represented through fragments, which becomes the fundamental dialectical reference for a reflection on problems crucial to the young Palestinian actors, as identity, relations, vengeance, oblivion. Situating this extraordinary theatrical event in relation to the reception of Hamlet in the Arab world, this article explores the narrative development of the reflection urged by an always contemporary Hamlet.

  6. The Simpsons' Shakespeare: Hamlet Today. Possible Meanings and Consequences of a Parodic Appropriaton

    Directory of Open Access Journals (Sweden)

    Maria Elisa Montironi

    2012-12-01

    Full Text Available Within a theoretical framework which includes receptions theory and the theories on the afterlife of Shakespeare, this paper aims at illustrating how Shakespeare’s Hamlet has been formatted for contemporary audience by “The Simpsons”, the successful animated sitcom that shares with the English playwright more than one feature, primarily the fact of being a worldwide icon, thus a global phenomenon. First of all, the figure of Shakespeare will be described, as it is shown in many episodes of the series, among the hundreds aired till now. Furthermore, the parody of Hamlet played by the beloved and well known yellow characters of the cartoon will be described, mainly pointing out the contemporary reading of the Renaissance text, and the way in which it influences its circulation in our society.

  7. Municipalities' Priority Problems and Prospect of Establishing Ordinance to Measures for Marginal Hamlets

    Science.gov (United States)

    Nakanishi, Mayumi; Hoshino, Satoshi; Hashimoto, Shizuka; Kuki, Yasuaki

    The problems of Marginal Hamlets are getting worse, in which more than half of the population is over 65 and community-based life is difficult. To contribute to effective policy making, we conducted a questionnaire survey to members of the National Liaison Council of ‘Suigen no Sato’ constituted to share information about problems and effective counter measures for marginal hamlets. Our study clarified that first, most of respondents had common problems such as lack of job-opportunities and animal damage on farm, and second, though most of respondents recognized the effectiveness of selecting target communities in policy implementations, it is difficult for municipal governments to establish such ordinance provided that councilors and those who were not living in areas of policy target wouldn't agree with it. Finally, we pointed out the roles of national and prefectural governments to help municipal governments effectively cope with such entangled situations.

  8. A novel method for preparation of HAMLET-like protein complexes.

    Science.gov (United States)

    Permyakov, Sergei E; Knyazeva, Ekaterina L; Leonteva, Marina V; Fadeev, Roman S; Chekanov, Aleksei V; Zhadan, Andrei P; Håkansson, Anders P; Akatov, Vladimir S; Permyakov, Eugene A

    2011-09-01

    Some natural proteins induce tumor-selective apoptosis. α-Lactalbumin (α-LA), a milk calcium-binding protein, is converted into an antitumor form, called HAMLET/BAMLET, via partial unfolding and association with oleic acid (OA). Besides triggering multiple cell death mechanisms in tumor cells, HAMLET exhibits bactericidal activity against Streptococcus pneumoniae. The existing methods for preparation of active complexes of α-LA with OA employ neutral pH solutions, which greatly limit water solubility of OA. Therefore these methods suffer from low scalability and/or heterogeneity of the resulting α-LA - OA samples. In this study we present a novel method for preparation of α-LA - OA complexes using alkaline conditions that favor aqueous solubility of OA. The unbound OA is removed by precipitation under acidic conditions. The resulting sample, bLA-OA-45, bears 11 OA molecules and exhibits physico-chemical properties similar to those of BAMLET. Cytotoxic activities of bLA-OA-45 against human epidermoid larynx carcinoma and S. pneumoniae D39 cells are close to those of HAMLET. Treatment of S. pneumoniae with bLA-OA-45 or HAMLET induces depolarization and rupture of the membrane. The cells are markedly rescued from death upon pretreatment with an inhibitor of Ca(2+) transport. Hence, the activation mechanisms of S. pneumoniae death are analogous for these two complexes. The developed express method for preparation of active α-LA - OA complex is high-throughput and suited for development of other protein complexes with low-molecular-weight amphiphilic substances possessing valuable cytotoxic properties. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  9. p18(Hamlet) mediates different p53-dependent responses to DNA-damage inducing agents.

    Science.gov (United States)

    Lafarga, Vanesa; Cuadrado, Ana; Nebreda, Angel R

    2007-10-01

    Cells organize appropriate responses to environmental cues by activating specific signaling networks. Two proteins that play key roles in coordinating stress responses are the kinase p38alpha (MAPK14) and the transcription factor p53 (TP53). Depending on the nature and the extent of the stress-induced damage, cells may respond by arresting the cell cycle or by undergoing cell death, and these responses are usually associated with the phosphorylation of particular substrates by p38alpha as well as the activation of specific target genes by p53. We recently characterized a new p38alpha substrate, named p18(Hamlet) (ZNHIT1), which mediates p53-dependent responses to different genotoxic stresses. Thus, cisplatin or UV light induce stabilization of the p18(Hamlet) protein, which then enhances the ability of p53 to bind to and activate the promoters of pro-apoptotic genes such as NOXA and PUMA leading to apoptosis induction. In a similar way, we report here that p18(Hamlet) can also mediate the cell cycle arrest induced in response to gamma-irradiation, by participating in the p53-dependent upregulation of the cell cycle inhibitor p21(Cip1) (CDKN1A).

  10. Who is Mr. HAMLET? Interaction of human alpha-lactalbumin with monomeric oleic acid.

    Science.gov (United States)

    Knyazeva, Ekaterina L; Grishchenko, Valery M; Fadeev, Roman S; Akatov, Vladimir S; Permyakov, Sergei E; Permyakov, Eugene A

    2008-12-09

    A specific state of the human milk Ca(2+) binding protein alpha-lactalbumin (hLA) complexed with oleic acid (OA) prepared using an OA-pretreated ion-exchange column (HAMLET) triggers several cell death pathways in various tumor cells. The possibility of preparing a hLA-OA complex with structural and cytotoxic properties similar to those of the HAMLET but under solution conditions has been explored. The complex was formed by titration of hLA by OA at pH 8.3 up to OA critical micelle concentration. We have shown that complex formation strongly depends on calcium, ionic strength, and temperature; the optimal conditions were established. The spectrofluorimetrically estimated number of OA molecules irreversibly bound per hLA molecule (after dialysis of the OA-loaded preparation against water followed by lyophilization) depends upon temperature: 2.9 at 17 degrees C (native apo-hLA; resulting complex referred to as LA-OA-17 state) and 9 at 45 degrees C (thermally unfolded apo-hLA; LA-OA-45). Intrinsic tryptophan fluorescence measurements revealed substantially decreased thermal stability of Ca(2+)-free forms of HAMLET, LA-OA-45, and OA-saturated protein. The irreversibly bound OA does not affect the Ca(2+) association constant of the protein. Phase plot analysis of fluorimetric and CD data indicates that the OA binding process involves several hLA intermediates. The effective pseudoequilibrium OA association constants for Ca(2+)-free hLA were estimated. The far-UV CD spectra of Ca(2+)-free hLA show that all OA-bound forms of the protein are characterized by elevated content of alpha-helical structure. The various hLA-OA complexes possess similar cytotoxic activities against human epidermoid larynx carcinoma cells. Overall, the LA-OA-45 complex possesses physicochemical, structural, and cytotoxic properties closely resembling those of HAMLET. The fact that the HAMLET-like complex can be formed in aqueous solution makes the process of its preparation more transparent and

  11. Autophagy protein p62/SQSTM1 is involved in HAMLET-induced cell death by modulating apotosis in U87MG cells.

    Science.gov (United States)

    Zhang, Y-B; Gong, J-L; Xing, T-Y; Zheng, S-P; Ding, W

    2013-03-21

    HAMLET is a complex of oleic acids and decalcified α-lactalbumin that was discovered to selectively kill tumor cells both in vitro and in vivo. Autophagy is an important cellular process involved in drug-induced cell death of glioma cells. We treated U87MG human glioma cells with HAMLET and found that the cell viability was significantly decreased and accompanied with the activation of autophagy. Interestingly, we observed an increase in p62/SQSTM1, an important substrate of autophagosome enzymes, at the protein level upon HAMLET treatment for short periods. To better understand the functionality of autophagy and p62/SQSTM1 in HAMLET-induced cell death, we modulated the level of autophagy or p62/SQSTM1 with biochemical or genetic methods. The results showed that inhibition of autophagy aggravated HAMLET-induced cell death, whereas activation of authophagy attenuated this process. Meanwhile, we found that overexpression of wild-type p62/SQSTM1 was able to activate caspase-8, and then promote HAMLET-induced apoptosis, whereas knockdown of p62/SQSTM1 manifested the opposite effect. We further demonstrated that the function of p62/SQSTM1 following HAMLET treatment required its C-terminus UBA domain. Our results indicated that in addition to being a marker of autophagy activation in HAMLET-treated glioma cells, p62/SQSTM1 could also function as an important mediator for the activation of caspase-8-dependent cell death.

  12. Non-linear transverse dynamics for storage rings with application to the low-energy antiproton ring (LEAR) at CERN

    International Nuclear Information System (INIS)

    Bengtsson, J.

    1988-01-01

    A tensor equation has been used to derive the equations of motion for the curvilinear coordinate system customary used for accelerators. A Hamiltonian formalism, expanded to third order in the canonical variables, describing the transverse motion in an acceleration has also been developed. Time-dependent perturbation theory has been applied and computerized using a computer algebra system. In particular, the perturbations due to magnetic sextupoles have been calculated to second power in the sextupole strength. The frequency spectra for the betatron motion close to a single resonance has been calculated by using time-independent perturbation theory. It has been shown that information about excited resonances and the type of driving field can be derived from the spectra. In particular, it is possible to obtain the amplitude and the phase of a given resonance. The results have been used to study the perturbations in the Low Energy Antiproton Ring, LEAR at CERN. (With 67 refs.) (author)

  13. Non-linear transverse dynamics for storage rings with applications to the low-energy antiproton ring (LEAR) at CERN

    International Nuclear Information System (INIS)

    Bengtsson, J.

    1988-01-01

    A tensor equation has been used to derive the equations of motion for the curvilinear coordinate system customarily used for particle accelerators. A Hamiltonian formalism, expanded to third order in the canonical variables, has also been developed to describe the transverse motion in an accelerator. Time-dependent perturbation theory has been applied and computerized using a computer-algebra system. In particular, the perturbations due to magnetic sextupoles have been calculated to second power in the sextupole strength. The frequency spectra for the horizontal and the vertical betatron motion close to a single resonance have been calculated using time-independent perturbation theory. It has been shown that information about excited resonances and the type of driving field can be derived from the spectra. In particular, it is possible to obtain the amplitude and the phase of a given resonance. The results have been used to study the perturbations in the Low Energy Antiproton Ring (LEAR) at CERN. (orig.)

  14. The Dialogue with Hamlet: Paul-Eerik Rummo’s “Hamlet’s Songs” as an Example of the Existential Paradigm in Estonian Culture

    Directory of Open Access Journals (Sweden)

    Anneli Mihkelev

    2013-06-01

    Full Text Available The article demonstrates different meanings of the motif of Hamlet in the Estonian culture. Hamlet as a literary figure has been very important and influential, a symbol of will and a fighter in a hopeless situation. Paul-Eerik Rummo’s poem “Hamlet’s Songs” (1964 forms the centre around which revolve not only written texts but also many such cultural texts as theatre performances and music, all connected by allusions to Hamlet. Rummo’s poem is one of the most innovative poems from the 1960s in Estonian literature. The generation of the 1960s was influenced by several important contemporary theories, including existentialism. Many young writers systematically undermined the Soviet regime in their works. The use of the motif of Hamlet reveals a similarity between the existential and romantic rebellions. Rummo’s dialogue with Hamlet in his poem expresses optimism in a hopeless situation in a way different from Shakespeare’s.

  15. Molecular Mechanisms of the Cytotoxicity of Human α-Lactalbumin Made Lethal to Tumor Cells (HAMLET) and Other Protein-Oleic Acid Complexes*

    Science.gov (United States)

    Nakamura, Takashi; Aizawa, Tomoyasu; Kariya, Ryusho; Okada, Seiji; Demura, Makoto; Kawano, Keiichi; Makabe, Koki; Kuwajima, Kunihiro

    2013-01-01

    Although HAMLET (human α-lactalbumin made lethal to tumor cells), a complex formed by human α-lactalbumin and oleic acid, has a unique apoptotic activity for the selective killing of tumor cells, the molecular mechanisms of expression of the HAMLET activity are not well understood. Therefore, we studied the molecular properties of HAMLET and its goat counterpart, GAMLET (goat α-lactalbumin made lethal to tumor cells), by pulse field gradient NMR and 920-MHz two-dimensional NMR techniques. We also examined the expression of HAMLET-like activities of complexes between oleic acid and other proteins that form a stable molten globule state. We observed that both HAMLET and GAMLET at pH 7.5 were heterogeneous, composed of the native protein, the monomeric molten globule-like state, and the oligomeric species. At pH 2.0 and 50 °C, HAMLET and GAMLET appeared in the monomeric state, and we identified the oleic acid-binding site in the complexes by two-dimensional NMR. Rather surprisingly, the binding site thus identified was markedly different between HAMLET and GAMLET. Furthermore, canine milk lysozyme, apo-myoglobin, and β2-microglobulin all formed the HAMLET-like complex with the anti-tumor activity, when the protein was treated with oleic acid under conditions in which their molten globule states were stable. From these results, we conclude that the protein portion of HAMLET, GAMLET, and the other HAMLET-like protein-oleic acid complexes is not the origin of their cytotoxicity to tumor cells and that the protein portion of these complexes plays a role in the delivery of cytotoxic oleic acid molecules into tumor cells across the cell membrane. PMID:23580643

  16. Molecular mechanisms of the cytotoxicity of human α-lactalbumin made lethal to tumor cells (HAMLET) and other protein-oleic acid complexes.

    Science.gov (United States)

    Nakamura, Takashi; Aizawa, Tomoyasu; Kariya, Ryusho; Okada, Seiji; Demura, Makoto; Kawano, Keiichi; Makabe, Koki; Kuwajima, Kunihiro

    2013-05-17

    Although HAMLET (human α-lactalbumin made lethal to tumor cells), a complex formed by human α-lactalbumin and oleic acid, has a unique apoptotic activity for the selective killing of tumor cells, the molecular mechanisms of expression of the HAMLET activity are not well understood. Therefore, we studied the molecular properties of HAMLET and its goat counterpart, GAMLET (goat α-lactalbumin made lethal to tumor cells), by pulse field gradient NMR and 920-MHz two-dimensional NMR techniques. We also examined the expression of HAMLET-like activities of complexes between oleic acid and other proteins that form a stable molten globule state. We observed that both HAMLET and GAMLET at pH 7.5 were heterogeneous, composed of the native protein, the monomeric molten globule-like state, and the oligomeric species. At pH 2.0 and 50 °C, HAMLET and GAMLET appeared in the monomeric state, and we identified the oleic acid-binding site in the complexes by two-dimensional NMR. Rather surprisingly, the binding site thus identified was markedly different between HAMLET and GAMLET. Furthermore, canine milk lysozyme, apo-myoglobin, and β2-microglobulin all formed the HAMLET-like complex with the anti-tumor activity, when the protein was treated with oleic acid under conditions in which their molten globule states were stable. From these results, we conclude that the protein portion of HAMLET, GAMLET, and the other HAMLET-like protein-oleic acid complexes is not the origin of their cytotoxicity to tumor cells and that the protein portion of these complexes plays a role in the delivery of cytotoxic oleic acid molecules into tumor cells across the cell membrane.

  17. Apoptosis-like death in bacteria induced by HAMLET, a human milk lipid-protein complex.

    Directory of Open Access Journals (Sweden)

    Anders P Hakansson

    Full Text Available BACKGROUND: Apoptosis is the primary means for eliminating unwanted cells in multicellular organisms in order to preserve tissue homeostasis and function. It is characterized by distinct changes in the morphology of the dying cell that are orchestrated by a series of discrete biochemical events. Although there is evidence of primitive forms of programmed cell death also in prokaryotes, no information is available to suggest that prokaryotic death displays mechanistic similarities to the highly regulated programmed death of eukaryotic cells. In this study we compared the characteristics of tumor and bacterial cell death induced by HAMLET, a human milk complex of alpha-lactalbumin and oleic acid. METHODOLOGY/PRINCIPAL FINDINGS: We show that HAMLET-treated bacteria undergo cell death with mechanistic and morphologic similarities to apoptotic death of tumor cells. In Jurkat cells and Streptococcus pneumoniae death was accompanied by apoptosis-like morphology such as cell shrinkage, DNA condensation, and DNA degradation into high molecular weight fragments of similar sizes, detected by field inverse gel electrophoresis. HAMLET was internalized into tumor cells and associated with mitochondria, causing a rapid depolarization of the mitochondrial membrane and bound to and induced depolarization of the pneumococcal membrane with similar kinetic and magnitude as in mitochondria. Membrane depolarization in both systems required calcium transport, and both tumor cells and bacteria were found to require serine protease activity (but not caspase activity to execute cell death. CONCLUSIONS/SIGNIFICANCE: Our results suggest that many of the morphological changes and biochemical responses associated with apoptosis are present in prokaryotes. Identifying the mechanisms of bacterial cell death has the potential to reveal novel targets for future antimicrobial therapy and to further our understanding of core activation mechanisms of cell death in eukaryote cells.

  18. Apoptosis-like death in bacteria induced by HAMLET, a human milk lipid-protein complex.

    Science.gov (United States)

    Hakansson, Anders P; Roche-Hakansson, Hazeline; Mossberg, Ann-Kristin; Svanborg, Catharina

    2011-03-10

    Apoptosis is the primary means for eliminating unwanted cells in multicellular organisms in order to preserve tissue homeostasis and function. It is characterized by distinct changes in the morphology of the dying cell that are orchestrated by a series of discrete biochemical events. Although there is evidence of primitive forms of programmed cell death also in prokaryotes, no information is available to suggest that prokaryotic death displays mechanistic similarities to the highly regulated programmed death of eukaryotic cells. In this study we compared the characteristics of tumor and bacterial cell death induced by HAMLET, a human milk complex of alpha-lactalbumin and oleic acid. We show that HAMLET-treated bacteria undergo cell death with mechanistic and morphologic similarities to apoptotic death of tumor cells. In Jurkat cells and Streptococcus pneumoniae death was accompanied by apoptosis-like morphology such as cell shrinkage, DNA condensation, and DNA degradation into high molecular weight fragments of similar sizes, detected by field inverse gel electrophoresis. HAMLET was internalized into tumor cells and associated with mitochondria, causing a rapid depolarization of the mitochondrial membrane and bound to and induced depolarization of the pneumococcal membrane with similar kinetic and magnitude as in mitochondria. Membrane depolarization in both systems required calcium transport, and both tumor cells and bacteria were found to require serine protease activity (but not caspase activity) to execute cell death. Our results suggest that many of the morphological changes and biochemical responses associated with apoptosis are present in prokaryotes. Identifying the mechanisms of bacterial cell death has the potential to reveal novel targets for future antimicrobial therapy and to further our understanding of core activation mechanisms of cell death in eukaryote cells.

  19. The city of the divine king

    DEFF Research Database (Denmark)

    Barnow, Niels Finn

    2001-01-01

    The City of the Divine King deals with urban systems and urban architecture in the river kingdoms of the Near East and the agrarian societies of the Orient. The book is part of a larger work comprising studies of the antique Greek world and the Roman Empire and the later developments of cities...... and villages in medieval Europe. The City of the Divine King is followed by volume 2: The City of the Landowner, about the Greco-Roman World, and volume 3: The City of the Merchant, about the medieval urban development in Europe....

  20. 76 FR 3819 - Martin Luther King, Jr., Federal Holiday, 2011

    Science.gov (United States)

    2011-01-20

    ... with the same strength, persistence, and determination exhibited by Dr. King, guided by the enduring... closer to Dr. King's vision of all Americans living and working together as one beloved community. NOW...

  1. Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival.

    Science.gov (United States)

    Fischer, Walter; Gustafsson, Lotta; Mossberg, Ann-Kristin; Gronli, Janne; Mork, Sverre; Bjerkvig, Rolf; Svanborg, Catharina

    2004-03-15

    Malignant brain tumors present a major therapeutic challenge because no selective or efficient treatment is available. Here, we demonstrate that intratumoral administration of human alpha-lactalbumin made lethal to tumor cells (HAMLET) prolongs survival in a human glioblastoma (GBM) xenograft model, by selective induction of tumor cell apoptosis. HAMLET is a protein-lipid complex that is formed from alpha-lactalbumin when the protein changes its tertiary conformation and binds oleic acid as a cofactor. HAMLET induces apoptosis in a wide range of tumor cells in vitro, but the therapeutic effect in vivo has not been examined. In this study, invasively growing human GBM tumors were established in nude rats (Han:rnu/rnu Rowett, n = 20) by transplantation of human GBM biopsy spheroids. After 7 days, HAMLET was administered by intracerebral convection-enhanced delivery for 24 h into the tumor area; and alpha-lactalbumin, the native, folded variant of the same protein, was used as a control. HAMLET reduced the intracranial tumor volume and delayed the onset of pressure symptoms in the tumor-bearing rats. After 8 weeks, all alpha-lactalbumin-treated rats had developed pressure symptoms, but the HAMLET-treated rats remained asymptomatic. Magnetic resonance imaging scans revealed large differences in tumor volume (456 versus 63 mm(3)). HAMLET caused apoptosis in vivo in the tumor but not in adjacent intact brain tissue or in nontransformed human astrocytes, and no toxic side effects were observed. The results identify HAMLET as a new candidate in cancer therapy and suggest that HAMLET should be additionally explored as a novel approach to controlling GBM progression.

  2. Hip-Hop Hamlet: Hybrid Interpretive Discourse in a Suburban High School English Class

    Directory of Open Access Journals (Sweden)

    Joanna L. Anglin

    2014-07-01

    Full Text Available This study investigates the collaborative composing processes of a group of five high school seniors who constructed interpretations of each of the five acts of Shakespeare’s Hamlet through the medium of spoken word performances. The group composing processes were analyzed to identify how the students drew on conventions from the spoken word tradition to phrase and perform their interpretations. Findings indicate that across the five spoken word performances, the retelling of the Hamlet narrative involved a set of decisions that were both constrained and afforded by the rap medium. The students’ discussion of how to rewrite the story in the condensed poetic form of a rap required them to clarify events from Shakespeare’s version and both summarize them and interpret them both in their discussion and in their own text. Their interpretive work involved the incorporation of a variety of rap and other pop culture conventions such that their deliberation regarding word choice and accompanying performative elements necessitated careful consideration of the meaning that they found in Shakespeare’s version of the story, itself an adaptation from extant cultural narratives. The study concludes with a consideration of their spoken word interpretations as comprising a hybrid discourse that enabled exploratory interpretive talk that contributed to their understanding of the drama through the collaborative composition of their own representational text.

  3. Speaking to the yet unknowing world: Hamlet, Horatio and the problem of imperfect witness.

    Science.gov (United States)

    Phillips, Christine

    2010-12-01

    Every day doctors bear witness to others about the experiences, needs and feelings of their patients, drawing on what they have learnt from clinical consultations. This paper considers the medical task of bearing honourable and truthful witness through an examination of the role and actions of Horatio in Hamlet. Horatio is simultaneously located among the background machinery of the play, separate from the lives of the protagonists, and in the foreground, where his authoritative witness is repeatedly called upon by the play's characters. Horatio is invited to watch an unfolding disaster, his warnings are not heard, and at its conclusion he stands apart from the drama to give its account. The tensions between engagement and observation, and between partial and impartial accounting echo those faced by doctors in everyday clinical practice. The act of bearing witness, Shakespeare suggests, even for those who are tasked with being objective, is necessarily imperfect, and not dispassionate. Those people, including doctors, who are expected to construct authoritative accounts of the motives and actions of others may find in Hamlet a small lesson on the need to approach their summary narratives about others more humbly, aware of the narrowness and partiality of their perspective.

  4. ANÁLISE DOS EFEITOS DE FALA DO CONSELHEIRO REAL EM HAMLET

    Directory of Open Access Journals (Sweden)

    Thiago Martins Prado (UNEB

    2017-05-01

    Full Text Available

    Tomando por base como se realiza e qual a motivação das falas do personagem Polônio, o estudo investiga a composição do conselheiro real da peça Hamlet, de William Shakespeare. Os efeitos de fala de Polônio são classificados a fim de aprofundar a análise da argumentação desse personagem. Paralelamente, confrontam-se hipóteses levantadas por Stephen Greenblatt (2011 e por Manoel Hygino dos Santos (1965 sobre a relação entre acontecimentos históricos que influenciaram a escrita shakespeariana a respeito da concepção do conselheiro Polônio. Para combater as interpretações redutoras sobre o personagem Polônio, o estudo valoriza a complexidade dos contextos de fala do conselheiro.

    Palavras-chave: Conselheiro Polônio. Argumentação do conselheiro real em Hamlet. Mapeamento de efeitos de fala. Shakespeare.

  5. Topographical memory analyzed in mice using the Hamlet test, a novel complex maze.

    Science.gov (United States)

    Crouzier, Lucie; Gilabert, Damien; Rossel, Mireille; Trousse, Françoise; Maurice, Tangui

    2018-03-01

    The Hamlet test is an innovative device providing a complex environment for testing topographic memory in mice. Animals were trained in groups for weeks in a small village with a central agora, streets expanding from it towards five functionalized houses, where they can drink, eat, hide, run, interact with a stranger mouse. Memory was tested by depriving mice from water or food and analyzing their ability to locate the Drink/Eat house. Exploration and memory were analyzed in different strains, gender, and after different training periods and delays. After 2 weeks training, differences in exploration patterns were observed between strains, but not gender. Neuroanatomical structures activated by training, identified using FosB/ΔFosB immunolabelling, showed an involvement of the hippocampus-subiculum-parahippocampal gyrus axis and dopaminergic structures. Training increased hippocampal neurogenesis (cell proliferation and neuronal maturation) and modified the amnesic efficacy of muscarinic or nicotinic cholinergic antagonists. Moreover, topographical disorientation in Alzheimer's disease was addressed using intracerebroventricular injection of amyloid β 25-35 peptide in trained mice. When retested after 7 days, Aβ 25-35 -treated mice showed memory impairment. The Hamlet test specifically allows analysis of topographical memory in mice, based on complex environment. It offers an innovative tool for various ethological or pharmacological research needs. For instance, it allowed to examine topographical disorientation, a warning sign in Alzheimer's disease. Copyright © 2018 Elsevier Inc. All rights reserved.

  6. 78 FR 5247 - Martin Luther King, Jr., Federal Holiday, 2013

    Science.gov (United States)

    2013-01-24

    ..., 2013 Martin Luther King, Jr., Federal Holiday, 2013 By the President of the United States of America A... thousands upon thousands rallying for jobs and freedom, the Reverend Dr. Martin Luther King, Jr., delivered... Constitution and the laws of the United States, do hereby proclaim January 21, 2013, as the Martin Luther King...

  7. The Newest Monument: The Martin Luther King, Jr. National Memorial

    Science.gov (United States)

    Social Studies and the Young Learner, 2011

    2011-01-01

    This article features the newest monument, the Martin Luther King, Jr. National Memorial. The memorial on the National Mall in Washington, D.C., honoring Dr. Martin Luther King, Jr. will be an engaging landscape experience to convey four fundamental and recurring themes throughout Dr. King's life--democracy, justice, hope, and love. Natural…

  8. «Eu era Hamlet»: o desejo de substituição em Hamletmaschine, de Heiner Müller

    OpenAIRE

    Gomes, Miguel Ramalhete

    2009-01-01

    «I was Hamlet»: desire for substitution in Heiner Müller’s Hamletmaschine. In this essay I propose a reading of Heiner Müller’s play Hamletmaschine (1977) as a radical exercise in rewriting William Shakespeare’s Hamlet. As a follow-up to his translation of Hamlet into German, Müller writes this nine-page play as a comment to the political situation in Eastern Europe in the 1960’s and 1970’s. Because of its size, the play strikes us as a dense form, close to the fragment form, foreshadow...

  9. "King Corn": Teaching the Food Crisis

    Science.gov (United States)

    Swinehart, Tim

    2012-01-01

    "King Corn" is in so many ways the story of how government food policy has entirely remade the food landscape in the United States over the last 40 years. From the massive expansion of the number of acres of corn grown across the country, to the ever-increasing ways that corn is incorporated into the food production process, to the…

  10. The King under the Car Park

    Science.gov (United States)

    Mirza, Ather

    2015-01-01

    In February 2013, the University of Leicester staged what The Guardian described as "The most extraordinary press conference ever held at any UK university." This was part of a media and communications campaign that brought worldwide attention to the discovery of King Richard III by the University's archaeologists. How do you manage a…

  11. Briti publik armastab King Kongi / Andris Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Andris, 1982-

    2006-01-01

    Briti filmiajakiri Empire lugejate filmiauhinnad : parim film "King Kong" (Peter Jackson), parim režii Steve Box, Nick Park "Wallace & Gromit - libaküüliku needus", parim meesnäitleja Johnny Depp, parim naisnäitleja Thandie Newton

  12. Tribute to Julie Taymor's Lion King Costumes

    Science.gov (United States)

    Carter, Mary C.; Beaty, Ben

    2011-01-01

    Julie Taymor's costumes and masks for the stage version of "The Lion King" were stunning in the way they combined the dual images of human and animal forms. Taymor visually incorporated the human form of a dancer into the simplified form of the animal character so both are equally visible. This visible duality of human form and animal…

  13. Anogeissus sericea var. nummalaria King ex Duthie

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 4. Anogeissus sericea var. nummalaria King ex Duthie. Flowering Trees Volume 8 Issue 4 April 2003 pp 89-89. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/008/04/0089-0089. Resonance ...

  14. EDITORIAL: King of the elements? King of the elements?

    Science.gov (United States)

    Demming, Anna

    2010-07-01

    Throughout the history of science, carbon-based research has played a defining role in the development of a range of fundamental and technological fields. It was used in Avagadro's definition of the mole in the early 18th century, it provides the 'backbone' of molecules in organic compounds, and in the environmental debate currently raging in the press and international government discussions, the 'carbon footprint' has become the metric of our species' impact on our planet. Also in nanotechnology, with the discovery of various wonder materials, carbon is once again asserting its claim as king of the elements. Until the 1980s the only known forms of carbon were diamond, graphite and amorphous carbon, as in soot or charcoal. In 1985 Robert Curl, Harold Kroto and Richard Smalley reported the existence of fullerenes, spherical structures comprising hexagonal carbon rings [1], work for which they won the Nobel Prize for Chemistry in 1996 [2]. The discovery of fullerenes was followed in 1991 by Sumio Ijima with the discovery of rolled graphite sheets, the carbon nanotube [3]. The discovery of these novel carbon nanostructures inspired researchers in a range of fields, largely as a result of the extraordinary capacity for investigations of these structures to reveal ever more intriguing properties. One of the fascinating properties attributed to carbon nanotubes is their phenomenal strength, with a Young's modulus of single walled carbon nanotubes approaching a terapascal [4]. Ingenious methods of harnessing this strength have since been developed, including bucky paper, a term used to refer to a mat of randomly self-entangled carbon nanotubes. Steven Crannford and Markus Buehler have recently reported a novel computational technique for probing the mechanical properties of these structures and show that the Young's modulus of bucky paper can be tuned by manipulation of the carbon nanotube type and density [5]. The electrical properties of carbon nanotubes, which depend

  15. John Davies of Hereford, the King of Denmark & Shakespeare's Meeting of Kings: Praise Beyond Praise

    DEFF Research Database (Denmark)

    Sterrett, Joseph William

    2016-01-01

    This article traces the response and style of John Davies of Hereford, 'an ordinary man' as he celebrated an extraordinary event, the state visit of the King of Denmark to the court of James I in 1606. It then draws comparisons to Shakespeare's meeting of kings some seven or eight years later...... at the beginning of the late history play, All is True, suggesting that the earlier poet's experience influenced the latter....

  16. Chilean Antarctic Stations on King George Island

    Directory of Open Access Journals (Sweden)

    Katsutada Kaminuma

    2000-07-01

    Full Text Available The purpose of my visit to Chilean Antarctic Stations was to assess the present status of geophysical observations and research, as the South Shetland Island, West Antarctica, where the stations are located, are one of the most active tectonic regions on the Antarctic plate. The Instituto Antartico Chileno (INACH kindly gave me a chance to stay in Frei/Escudero Bases as an exchange scientist under the Antarctic Treaty for two weeks in January 2000. I stayed in Frei Base as a member of a geological survey group named "Tectonic Evolution of the Antarctic Peninsula" which was organized by Prof. F. Herve, University of Chile, from January 05 to 19,2000. All my activity in the Antarctic was organized by INACH. During my stay in Frei Base, I also visited Bellingshausen (Russian, Great Wall (China and Artigas (Uruguay stations. All these stations are located within walking distance of Frei Base. King Sejong Station (Korea, located 10km east from Frei Base, and Jubany Base (Argentine, another 6km south-east from King Sejong Station, were also visited with the aid of a zodiac boat that was kindly operated for us by King Sejong Station. All stations except Escudero Base carry out meteorological observations. The seismological observations in Frei Base are operated by Washington State University of the U. S. monitoring of earthquake activity and three-component geomagnetic observations are done at King Sejong and Great Wall stations. Earth tide is monitored at Artigas Base. Continuous monitoring of GPS and gravity change are planned at King Sejong Station in the near future. Scientific research activities of each country in the area in the 1999/2000 Antarctic summer season were studied and the logistic ability of all stations was also assessed for our future international cooperation.

  17. From Shakespeare to Kierkegaard: An Existential Reading of Hamlet = Shakespeare'den Kierkegaard'a: Varoluşçuluk Işığında

    Directory of Open Access Journals (Sweden)

    Aslı TEKİNAY

    2001-06-01

    Full Text Available Shakespeare's Hamlet yields conveniently to an existential reading. Hamlet may be seen as the prototype of the modern European man who struggles in a "rotten" world. In Denmark, he finds himself in a Sartrean "void". As he struggles to overcome his "nausea" by trying to unmask men, strip them of their fine appearances and show them in their true nature, Hamlet passes through the three stages of life described by Kierkegaard: the aesthetic, the ethical and the religious. Since these stages are in contradiction with one another, there is a basic choice, an "either/or" facing man. Hamlet's actions or non-actions in the play can be studied within the framework of this context.

  18. HAMLET -Matroshka IIA and IIB experiments aboard the ISS: comparison of organ doses

    Science.gov (United States)

    Kato, Zoltan; Reitz, Guenther; Berger, Thomas; Bilski, Pawel; Hajek, Michael; Sihver, Lembit; Palfalvi, Jozsef K.; Hager, Luke; Burmeister, Soenke

    The Matroshka experiments and the related FP7 HAMLET project aimed to study the dose burden of the cosmic rays in the organs of the crew working inside and outside the ISS. Two of the experiments will be discussed. They were performed in two different locations inside the ISS: during the Matroshka 2A (in 2006) the phantom was stored in the Russian Docking Module (Pirs), while during the Matroshka 2B (in 2007-08) it was inside the Russian Service Module (Zvezda). Both experiments were performed in the decreasing phase of the solar cycle. Solid state nuclear track detectors (SSNTD) were applied to investigate the dose contribution of the high LET radiation above ˜10 keV/µm. Two configurations of SSNTDs stacks were constructed: one for the exposure in the so called organ dose boxes (in the lung and kidney), another one for the skin dose measurements, embedded in the nomex poncho of the Phantom. In addition a reference package was placed outside the phantom. After exposure the detectors were transferred to the Earth for data evaluation. Short and long etching procedures were applied to distinguish the high and low LET particles, respectively. The particle tracks were evaluated by a semi automated image analyzer. Addi-tionally manual track parameter measurements were performed on very long tracks. As the result of measurements the LET spectra were deduced. Based on these spectra, the absorbed dose, the dose equivalent and the mean quality factor were calculated. The configuration of the stacks, the methods of the calibration and evaluation and finally the results will be presented and compared. The multiple etching and the combined evaluation method allowed to determine the fraction of the dose originated from HZE particles (Z>2 and range > major axis). Further on, data eval-uation was performed to separate the secondary particles (target fragments) from the primary particles. Although the number of high LET particles above a ˜80 keV/µm was found to be higher during

  19. HAMLET -Human Model MATROSHKA for Radiation Exposure Determination of Astronauts -Current status and results

    Science.gov (United States)

    Reitz, Guenther; Berger, Thomas; Bilski, Pawel; Burmeister, Soenke; Labrenz, Johannes; Hager, Luke; Palfalvi, Jozsef K.; Hajek, Michael; Puchalska, Monika; Sihver, Lembit

    The exploration of space as seen in specific projects from the European Space Agency (ESA) acts as groundwork for human long duration space missions. One of the main constraints for long duration human missions is radiation. The radiation load on astronauts and cosmonauts in space (as for the ISS) is a factor of 100 higher than the natural radiation on Earth and will further increase should humans travel to Mars. In preparation for long duration space missions it is important to evaluate the impact of space radiation in order to secure the safety of the astronauts and minimize their radiation risks. To determine the radiation risk on humans one has to measure the radiation doses to radiosensitive organs within the human body. One way to approach this is the ESA facility MATROSHKA (MTR), under the scientific and project lead of DLR. It is dedicated to determining the radiation load on astronauts within and outside the International Space Station (ISS), and was launched in January 2004. MTR is currently preparing for its fourth experimental phase inside the Japanese Experimental Module (JEM) in summer 2010. MTR, which mimics a human head and torso, is an anthropomorphic phantom containing over 6000 radiation detectors to determine the depth dose and organ dose distribution in the body. It is the largest international research initiative ever performed in the field of space dosimetry and combines the expertise of leading research institutions around the world, thereby generating a huge pool of data of potentially immense value for research. Aiming at optimal scientific exploitation, the FP7 project HAMLET aims to process and compile the data acquired individually by the participating laboratories of the MATROSHKA experiment. Based on experimental input from the MATROSHKA experiment phases as well as on radiation transport calculations, a three-dimensional model for the distribution of radiation dose in an astronaut's body will be built up. The scientific achievements

  20. Paul Cefalu. Revisionist Shakespeare: Transitional Ideologies in Texts and Contexts

    Directory of Open Access Journals (Sweden)

    Rainer EMIG

    2006-06-01

    Full Text Available Paul Cefalu, Assistant Professor of English at Lafayette College, offers five essays, three of which have previously appeared in different versions in periodicals, in this stimulating, but also sometimes puzzling and even frustrating book. That he aims for a revision of the core of Shakespearean Studies is already evident in his choice of objects for his analysis: The Tempest, Coriolanus, The Merchant of Venice, King Lear, and Hamlet. Yet “revisionist” is only implicitly applied to Cefalu's o...

  1. Re-reading early modern prayer as social act

    DEFF Research Database (Denmark)

    Sterrett, Joseph William

    2013-01-01

    Literary criticism is increasingly interested in prayer as a cultural and literary mode. This article proposes a theoretical framework for reading prayer as a performance, as an act governed by community conventions with effects in the social world. Drawing upon groundbreaking work by Marcel Maus...... and Hans Georg Gadamer, and citing critical reading of Shakespeare’s King Lear, The Tempest, and Hamlet, I show how prayer can be read as an act defined by real and imagined audiences while retaining individual self expression....

  2. ダイエットの詩学 : シェイクスピアの四大悲劇における

    OpenAIRE

    滝川, 睦; Takikawa, Mutsumu

    2018-01-01

    This paper is intended as an investigation of the poetics of diet in Shakespeare’s major tragedies: Hamlet, Othello, King Lear, and Macbeth. As Michel Jeanneret suggests in A Feast of Words: Banquets and Table Talk in the Renaissance, it is right to say that the dietetics in early modern England “prescribes rational control over one’s eating” for gluttons, and that it “seeks to control bodily instincts and subject them to a form of social censure” (73). However, in this study, the main stress...

  3. Lipids as tumoricidal components of human α-lactalbumin made lethal to tumor cells (HAMLET): unique and shared effects on signaling and death.

    Science.gov (United States)

    Ho, James C S; Storm, Petter; Rydström, Anna; Bowen, Ben; Alsin, Fredrik; Sullivan, Louise; Ambite, Inès; Mok, K H; Northen, Trent; Svanborg, Catharina

    2013-06-14

    Long-chain fatty acids are internalized by receptor-mediated mechanisms or receptor-independent diffusion across cytoplasmic membranes and are utilized as nutrients, building blocks, and signaling intermediates. Here we describe how the association of long-chain fatty acids to a partially unfolded, extracellular protein can alter the presentation to target cells and cellular effects. HAMLET (human α-lactalbumin made lethal to tumor cells) is a tumoricidal complex of partially unfolded α-lactalbumin and oleic acid (OA). As OA lacks independent tumoricidal activity at concentrations equimolar to HAMLET, the contribution of the lipid has been debated. We show by natural abundance (13)C NMR that the lipid in HAMLET is deprotonated and by chromatography that oleate rather than oleic acid is the relevant HAMLET constituent. Compared with HAMLET, oleate (175 μm) showed weak effects on ion fluxes and gene expression. Unlike HAMLET, which causes metabolic paralysis, fatty acid metabolites were less strongly altered. The functional overlap increased with higher oleate concentrations (500 μm). Cellular responses to OA were weak or absent, suggesting that deprotonation favors cellular interactions of fatty acids. Fatty acids may thus exert some of their essential effects on host cells when in the deprotonated state and when presented in the context of a partially unfolded protein.

  4. Feeding performance of king Mackerel, Scomberomorus cavalla.

    Science.gov (United States)

    Ferguson, Amber R; Huber, Daniel R; Lajeunesse, Marc J; Motta, Philip J

    2015-08-01

    Feeding performance is an organism's ability to capture and handle prey. Although bite force is a commonly used metric of feeding performance, other factors such as bite pressure and strike speed are also likely to affect prey capture. Therefore, this study investigated static bite force, dynamic speeds, and predator and prey forces resulting from ram strikes, as well as bite pressure of the king mackerel, Scomberomorus cavalla, in order to examine their relative contributions to overall feeding performance. Theoretical posterior bite force ranged from 14.0-318.7 N. Ram speed, recorded with a rod and reel incorporated with a line counter and video camera, ranged from 3.3-15.8B L/s. Impact forces on the prey ranged from 0.1-1.9 N. Bite pressure, estimated using theoretical bite forces at three gape angles and tooth cross-sectional areas, ranged from 1.7-56.9 MPa. Mass-specific bite force for king mackerel is relatively low in comparison with other bony fishes and sharks, with relatively little impact force applied to the prey during the strike. This suggests that king mackerel rely on high velocity chases and high bite pressure generated via sharp, laterally compressed teeth to maximize feeding performance. © 2015 Wiley Periodicals, Inc.

  5. Stick balancing, falls and Dragon-Kings

    Science.gov (United States)

    Cabrera, J. L.; Milton, J. G.

    2012-05-01

    The extent to which the occurrence of falls, the dominant feature of human attempts to balance a stick at their fingertip, can be predicted is examined in the context of the "Dragon-King" hypothesis. For skilled stick balancers, fluctuations in the controlled variable, namely the vertical displacement angle θ, exhibit power law behaviors. When stick balancing is made less stable by either decreasing the length of the stick or by requiring the subject to balance the stick on the surface of a table tennis racket, systematic departures from the power law behaviors are observed in the range of large θ. This observation raises the possibility that the presence of departures from the power law in the large length scale region, possibly Dragon-Kings, may identify situations in which the occurrence of a fall is more imminent. However, whether or not Dragon-Kings are observed, there is a Weibull-type survival function for stick falling. The possibility that increased risk of falling can, at least to some extent, be predicted from fluctuations in the controlled variable before the event occurs has important implications for the development of preventative strategies for the management of phenomena ranging from earthquakes to epileptic seizures to falls in the elderly.

  6. Bovine lactoferrin binds oleic acid to form an anti-tumor complex similar to HAMLET.

    Science.gov (United States)

    Fang, Bing; Zhang, Ming; Tian, Mai; Jiang, Lu; Guo, Hui Yuan; Ren, Fa Zheng

    2014-04-04

    α-Lactalbumin (α-LA) can bind oleic acid (OA) to form HAMLET-like complexes, which exhibited highly selective anti-tumor activity in vitro and in vivo. Considering the structural similarity to α-LA, we conjectured that lactoferrin (LF) could also bind OA to obtain a complex with anti-tumor activity. In this study, LF-OA was prepared and its activity and structural changes were compared with α-LA-OA. The anti-tumor activity was evaluated by methylene blue assay, while the apoptosis mechanism was analyzed using flow cytometry and Western blot. Structural changes of LF-OA were measured by fluorescence spectroscopy and circular dichroism. The interactions of OA with LF and α-LA were evaluated by isothermal titration calorimetry (ITC). LF-OA was obtained by heat-treatment at pH8.0 with LD50 of 4.88, 4.95 and 4.62μM for HepG2, HT29, and MCF-7 cells, respectively, all of which were 10 times higher than those of α-LA-OA. Similar to HAMLET, LF-OA induced apoptosis in tumor cells through both death receptor- and mitochondrial-mediated pathways. Exposure of tryptophan residues and the hydrophobic regions as well as the loss of tertiary structure were observed in LF-OA. Besides these similarities, LF showed different secondary structure changes when compared with α-LA, with a decrease of α-helix and β-turn and an increase of β-sheet and random coil. ITC results showed that there was a higher binding number of OA to LF than to α-LA, while both of the proteins interacted with OA through van der Waals forces and hydrogen bonds. This study provides a theoretical basis for further exploration of protein-OA complexes. Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved.

  7. A New Reading of Shakespeare's King John.

    Science.gov (United States)

    Usher, Peter D.

    1995-12-01

    Shakespeare wrote King John c.1594, six years after the defeat of the Spanish Armada, and ~ 50 years after publication of the Copernican heliocentric hypothesis. It is said to be the most unhistorical of the History Plays, ``anomalous'', ``puzzling'', and ``odd'', and as such it has engendered far more than the customary range of interpretive opinion. I suggest that the play alerts Elizabethans not just to military and political threats, but to a changing cosmic world view, all especially threatening as they arise in Catholic countries. (a) Personification characterizes the play. John personifies the old order, while Arthur and the Dauphin's armies personify the new. I suggest that Shakespeare decenters King John just as Copernicus decentered the world. (b) Hubert menaces Arthur's eyes for a whole scene (4.1), but the need for such cruelty is not explained and is especially odd as Arthur is already under sentence of death (3.3.65-66). This hitherto unexplained anomaly suggests that the old order fears what the new might see. (c) Eleanor's confession is made only to Heaven and to her son the King (1.1.42-43), yet by echoing and word play the Messenger from France later reveals to John that he is privy to it (4.2.119-124). This circumstance has not been questioned heretofore. I suggest that the Messenger is like the wily Hermes (Mercury), chief communicator of the gods and patron of the sciences; by revealing that he moves in the highest circles, he tells John that he speaks with an authority that transcends even that of a king. The message from on high presages more than political change; it warns of a new cosmic and religious world order (d) Most agree that John is a weak king, so Shakespeare must have suspected flaws in the old ways. He would have known that Tycho Brahe's new star of 1572, the comet of 1577, and the 1576 model of his compatriot Thomas Digges, were shattering old ideas. (e) The tensions of the play are not resolved because in 1594 the new order was

  8. Characterization of the complete mitochondrial genome of the king pigeon (Columba livia breed king).

    Science.gov (United States)

    Zhang, Rui-Hua; He, Wen-Xiao; Xu, Tong

    2015-06-01

    The king pigeon is a breed of pigeon developed over many years of selective breeding primarily as a utility breed. In the present work, we report the complete mitochondrial genome sequence of king pigeon for the first time. The total length of the mitogenome was 17,221 bp with the base composition of 30.14% for A, 24.05% for T, 31.82% for C, and 13.99% for G and an A-T (54.22 %)-rich feature was detected. It harbored 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes, and one non-coding control region (D-loop region). The arrangement of all genes was identical to the typical mitochondrial genomes of pigeon. The complete mitochondrial genome sequence of king pigeon would serve as an important data set of the germplasm resources for further study.

  9. Yo, Hamlet!

    Science.gov (United States)

    Whelan, Debra Lau

    2007-01-01

    This article presents Alan Sitomer, an English teacher at Lynwood High School, and how he teaches his students classic literature through hip-hop. These at-risk students attend a severely overcrowded, low-performing school in East Los Angeles that's surrounded by what Sitomer describes as "gangs, guns, and drugs." Prostitutes work the…

  10. En veritabel ormegård

    DEFF Research Database (Denmark)

    Kuhlmann, Annelis

    2016-01-01

    William Shakespeare: King Lear. Iscenesættelse: Peter Langdal, Skuespilhuset, Store Scene, premiere den 5. februar 2016......William Shakespeare: King Lear. Iscenesættelse: Peter Langdal, Skuespilhuset, Store Scene, premiere den 5. februar 2016...

  11. Gender Identity and Gender Performativity in Shakespeare’s Selected Plays: Macbeth, Hamlet and Merry Wives of Windsor

    Directory of Open Access Journals (Sweden)

    Mehdi Amiri

    2017-08-01

    Full Text Available The main argument of this article is focused on three plays by William Shakespeare, Macbeth, Hamlet and Merry Wives of Windsor. There are several points in these plays which deal with woman and their rights. This article deals with Shakespeare’s plays in relation to feminism, which pays more attention to the rights of women and their true identity. In all societies women are defined in terms of their relations to men as the center of power to which women have limited or no access. Judith Butler's performativity is significance on understandings of gender identity. Butler believes that gender is produced in society; also it can be changed in society. Feminism should aim to create a society in which, one's sexual anatomy is irrelevant to who one is, and what one does. Shakespeare’s view of a woman is shown through his representation of female characters in his plays specifically in Macbeth, Hamlet and Merry Wives of Windsor.

  12. Tròpics de Shakespeare : orígens i originalitat del Hamlet català

    OpenAIRE

    Buffery, Helena

    2009-01-01

    Hamlet és una de les obres que més ha inspirat autors, actors, directors i dramaturgs catalans. De fet, es podria dir, com en altres cultures europees, que és l'obra que determina tota traducció i representació posterior de Shakespeare, i que marca els orígens de la seva influència en la tradició cultural europea. Aquest article presenta la història retòrica del Hamlet català mitjançant les traduccions, les adaptacions i altres formes de reescritura de l'obra, a més de la seva representació t...

  13. Pessoa’s myth of the King Sebastian reinterpreted

    OpenAIRE

    Monika Świda

    2013-01-01

    The present paper depicts alterations undergone by the sleeping king motif (sebastianism) in the writings of Fernando Pessoa. The data to conduct the study were collected in thematic anthologies and several unpublished pieces. The myth of the King Sebastian was given a congregational dimension by Pessoa, thus conveying his cultural and identity project subsumed under the metaphor of the spiritual empire. Pessoa introduces some readjustments in the way the historical king is to be conceived of...

  14. "A little more than kin" - Quotations as a linguistic phenomenon : a study based on quotations from Shakespeare's Hamlet

    OpenAIRE

    Quassdorf, Sixta

    2016-01-01

    Quotations "oscillate between the occasional and the conventional" as Burger/Buhofer/Sialm (1982) once succinctly formulated. Developed from a PhD thesis, this book explores precisely this "oscillating" character of quotations: It discusses the nature of quotations and the relationship between common quotations and phraseology from a theoretical and an empirical perspective. Shakespeare's Hamlet was chosen as a canonical text whose frequently quoted traces can be followed across centuries. Sc...

  15. Goldie Brangman Remembers the Operation to Save Dr King.

    Science.gov (United States)

    Koch, Evan; Brangman, Goldie

    2015-12-01

    In September 1958 the Rev Dr Martin Luther King Jr was stabbed and nearly assassinated. Surgeons at Harlem Hospital in New York City removed a 17.8-cm (7-in)-long letter opener from Dr King's chest. Certified Registered Nurse Anesthetist Goldie Brangman remembers this event because she participated in Dr King's anesthetic. This article correlates Brangman's memories with published accounts of the event. It also places the event within the context of the modern civil rights movement that Dr King led.

  16. Bad Boys Meet the Swan of Avon: A Re-Visioning of Hamlet in Sons of Anarchy

    Directory of Open Access Journals (Sweden)

    Burzyńska Katarzyna

    2017-12-01

    Full Text Available This article investigates the intersections between Shakespeare’s Hamlet and a popular TV series Sons of Anarchy (SOA, loosely based on the Shakespearean original. The crime drama series revolves around an outlaw motorcycle club that literally “rules” a fictional town in California like an old royal family with its own brutal dynastic power squabbles and dark family secrets. The club is governed by an unscrupulous President Clay and an equally violent, though more conflicted, Vice President Jax Teller, the son of the late President, who had died in mysterious circumstances. In the article I argue that the popularity of the series lies not in its graphic scenes of violence, over-the-top Harley chases, and sex intrigues, but rather in its Shakespearean and Renaissance structure. SOA, dubbed as “Hamlet on Harleys”1, is an appropriation rather than an adaptation of Shakespeare’s tragedy, which makes it a truly transmedial phenomenon. The article investigates a fascinating blend of seemingly marginal elements of modern American culture and the canonical British tragedy. It also addresses the connections between the lifestyles of the so called outlaw MC clubs and the early modern family structure as presented in Hamlet, focusing on the issues of power and gender relations.

  17. A Palisade Fit for a King: Ideal architecture in King Harald Bluetooth's Jelling

    DEFF Research Database (Denmark)

    Jessen, Mads Dengsø; Holst, Mads Kähler; Lindblom, Charlotta

    2014-01-01

    family named on the rune stones in Jelling and in particular to the reign of King Harald Bluetooth. In addition to the structure and date of the palisade, the article will present the tentative results from a series of analyses regarding the construction, composition, function and demolition...

  18. King customer forever: Customer satisfaction and beyond

    Directory of Open Access Journals (Sweden)

    Myuers James

    2004-01-01

    Full Text Available "King Customer!" So proclaimed the front cover of Business Week in a 1989 issue. At about the same time, "Rediscovering the Customer" was the title of a series of company vignettes in Fortune magazine. And a Wall Street Journal article asked, "For Customers, More Than Lip Service?" Combined, these three prestigious business publications reflected a new era in business firms perceptions of their customers and the role they should play in the formulation of company strategies and priorities. Had the "Era of the Customer" finally arrived in American business? .

  19. King Kong tuli unenäost / Alar Niineväli

    Index Scriptorium Estoniae

    Niineväli, Alar

    2005-01-01

    Hiigelgorilla King Kongi sünd kinolinal 1933.a. Merian C. Cooperi õudusfilmis "King Kong" ja koletise hilisemad tulemised, ka koos jaapanlaste Godzillaga (1962) ja Tarzaniga india filmis "Tarzan ja King Kong" (1965)

  20. Yukon River King Salmon - Ichthyophonus Pilot Study

    Science.gov (United States)

    Kocan, R.M.; Hershberger, P.K.

    2001-01-01

    When king salmon enter the Yukon River on their spawning migration in mid June, over 25% of the population are infected with Ichthyophonus. The percent of infected fish remains relatively constant until the fish pass river mile 1,319 at Dawson, Y.T., then it drops to 13% when they reach river mile 1,745 at Whitehorse, Y.T. When the sexes are examined separately, slightly more females are infected than males (29% vs 22%). The percent of fish exhibiting clinical signs (diseased) is 2-3% when they enter the river, but increases to over 20% at river mile 715 near Tanana, AK. Disease prevalence within the population remains constant at >20% until fish pass Dawson, then the percent of diseased fish drops to <9% at Whitehorse. When the sexes are examined separately, male disease prevalence is highest at Tanana (22.6%) then gradually drops to just 12.9% at Whitehorse. Females however, continue to show an increase in disease prevalence peaking at river mile 1,081 near Circle, AK, at 36.4%, then dropping to just 5.3% at Whitehorse. Data on infection and disease collected from kings at Nenana on the Tanana River more closely resembles that seen at Whitehorse than the lower and middle Yukon River.

  1. King Harald V and Queen Sonja of Norway visit CERN

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    Norway's King Harald V and Queen Sonja take a tour of the ATLAS detector with CERN's Director-General Robert Aymar in April 2006. During their visit the royal party met with members of CERN's Norwegian community. A group of about 40 students greeted the royal motorcade with a belting rendition of 'The King's Song', Norway's royal anthem.

  2. The labour ward analgesic service at King Edward VIII Hospital ...

    African Journals Online (AJOL)

    The labour ward analgesic service at King Edward VIII. Hospital, Durban. D. A. ROCKE, C. C. ROUT, H. D. RUSSELL, S. SINGH. Abstract The provision of analgesic services to the labour ward at King Edward VIII Hospital was studied during a I-week period. Of249 patients, 113 (45%) received no analgesia whatsoever.

  3. The Applicability of Governance at King Saud University in Riyadh

    Science.gov (United States)

    Kentab, Mohammad Y.

    2018-01-01

    The problem of the study revolves around the application of the requirements of governance at King Saud University. The study aims to identify the extent of governance requirements at King Saud University as seen by faculty members through transparency, accountability, organizational structure, laws, regulations, and justice. To achieve the…

  4. Transcultural Hamlet: Representations of Ophelia and Gertrud in 21st-century Iran

    Directory of Open Access Journals (Sweden)

    Robabeh Jalayer

    2017-01-01

    Full Text Available Multitudes of intermedial Shakespearean adaptations, especially since 1975, have captured Iranian theatrical stage, cinema or radio as the Bard’s texts are frequently modernized, transfigured and indigenized in order to add to his globalization. Hamlet works well in the mechanisms of temporality, spatiality, power, control and sexuality, socio-political discourses, economic upheaval, female self and gender struggles even in the twentieth and twenty-first centuries. Hence, Iranian directors such as Varuzh Karim-Masihi and Arash Dadgar as well as the British director Gregory Doran have re-interpreted this text based on new ideological grounds in which the characters are at times similar or different. In this article, the transformation and characterization of major characters, especially female ones such as Gertrud/Mah-Tal’at and Ophelia/Mahtab, are analyzed based on Hutcheon’s Adaptation Theory to see how they are represented in an Asian society whose Islamic ideology necessitates a unique transcultural, transhistorical rendition.

  5. King and King: Learning to Treat Others Royally Through Diversity Education

    OpenAIRE

    Dube', Danielle

    2009-01-01

    Of the hate crimes reported to the FBI in 2007, 16.6% were the result of a sexual orientation bias. In the wake of horrific hate crimes such as the shooting and death of Lawrence King earlier this year, killed because of his sexual orientation, and the murder of Matthew Shepard ten years ago, homophobia and its effects must be addressed. A proposed solution to the problem is mandatory diversity education in public schools, with no parental opt out.

  6. Oedipus king: preparing man for the polis

    Directory of Open Access Journals (Sweden)

    José Joaquim Pereira Melo

    2013-09-01

    Full Text Available Having Sophoclean play Oedipus King as a frame of reference, the purpose of this paper is to discuss the educative proposal conceived to the Greek Man as preparation for life in the polis. Although not intentionally, Sophocles pointed out an ideal of Man which, in his perspective, would fulfill Greek societal demands of that time. Such society was divided between myth and rationality and, as a result, Man found Himself in conflict and lacking direction for His life. Given that, Oedipus’ character represented the ideal behavior of that society, and it also made it possible for citizens to reflect and to discuss social, economic and political transformations taking place at that period. Thus Sophocles came up with a hero who was an educational model and a citizen’s as well. Furthermore, such hero differed from that one of the archaic Greek thought.

  7. Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells).

    Science.gov (United States)

    Svensson, Malin; Fast, Jonas; Mossberg, Ann-Kristin; Düringer, Caroline; Gustafsson, Lotta; Hallgren, Oskar; Brooks, Charles L; Berliner, Lawrence; Linse, Sara; Svanborg, Catharina

    2003-12-01

    HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a complex of human alpha-lactalbumin and oleic acid (C18:1:9 cis) that kills tumor cells by an apoptosis-like mechanism. Previous studies have shown that a conformational change is required to form HAMLET from alpha-lactalbumin, and that a partially unfolded conformation is maintained in the HAMLET complex. This study examined if unfolding of alpha-lactalbumin is sufficient to induce cell death. We used the bovine alpha-lactalbumin Ca(2+) site mutant D87A, which is unable to bind Ca(2+), and thus remains partially unfolded regardless of solvent conditions. The D87A mutant protein was found to be inactive in the apoptosis assay, but could readily be converted to a HAMLET-like complex in the presence of oleic acid. BAMLET (bovine alpha-lactalbumin made lethal to tumor cells) and D87A-BAMLET complexes were both able to kill tumor cells. This activity was independent of the Ca(2+)site, as HAMLET maintained a high affinity for Ca(2+) but D87A-BAMLET was active with no Ca(2+) bound. We conclude that partial unfolding of alpha-lactalbumin is necessary but not sufficient to trigger cell death, and that the activity of HAMLET is defined both by the protein and the lipid cofactor. Furthermore, a functional Ca(2+)-binding site is not required for conversion of alpha-lactalbumin to the active complex or to cause cell death. This suggests that the lipid cofactor stabilizes the altered fold without interfering with the Ca(2+)site.

  8. Learing the 3Cs

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Chinese home appliance makers are trying to activate any link between computers, communication and consumer electronics It's a scene that has failed to materialize in the past, but companies in China are trying again: sitting in front of the television, the viewer surfs the Internet, buys things from online shops, plays online games and makes video phone calls. The TV will transform into a catch-all information appliance, to be used as computer and telephone. While the technology is already avail

  9. Hamlet no cinema: as adaptações fílmicas de Laurence Olivier (1948 e Franco Zeffirelli (1990

    Directory of Open Access Journals (Sweden)

    Rogério Tomaz

    2011-10-01

    Full Text Available As inter-relações entre as artes traduzem-se numa discussão bastante recente. Um dos elementos que compõem esse quadro é a tradução intersemiótica que consiste na relação entre sistemas signícos. Este artigo propõe a análise da abordagem intersemiótica na adaptação da peça de teatro Hamlet, Príncipe da Dinamarca, de William Shakespeare para o cinema nos filmes de Laurence Olivier e Franco Zeffirelli.

  10. Applications of site-specific labeling to study HAMLET, a tumoricidal complex of α-lactalbumin and oleic acid.

    Science.gov (United States)

    Mercer, Natalia; Ramakrishnan, Boopathy; Boeggeman, Elizabeth; Qasba, Pradman K

    2011-01-01

    Alpha-lactalbumin (α-LA) is a calcium-bound mammary gland-specific protein that is found in milk. This protein is a modulator of β1,4-galactosyltransferase enzyme, changing its acceptor specificity from N-acetyl-glucosamine to glucose, to produce lactose, milk's main carbohydrate. When calcium is removed from α-LA, it adopts a molten globule form, and this form, interestingly, when complexed with oleic acid (OA) acquires tumoricidal activity. Such a complex made from human α-LA (hLA) is known as HAMLET (Human A-lactalbumin Made Lethal to Tumor cells), and its tumoricidal activity has been well established. In the present work, we have used site-specific labeling, a technique previously developed in our laboratory, to label HAMLET with biotin, or a fluoroprobe for confocal microscopy studies. In addition to full length hLA, the α-domain of hLA (αD-hLA) alone is also included in the present study. We have engineered these proteins with a 17-amino acid C-terminal extension (hLA-ext and αD-hLA-ext). A single Thr residue in this extension is glycosylated with 2-acetonyl-galactose (C2-keto-galactose) using polypeptide-α-N-acetylgalactosaminyltransferase II (ppGalNAc-T2) and further conjugated with aminooxy-derivatives of fluoroprobe or biotin molecules. We found that the molten globule form of hLA and αD-hLA proteins, with or without C-terminal extension, and with and without the conjugated fluoroprobe or biotin molecule, readily form a complex with OA and exhibits tumoricidal activity similar to HAMLET made with full-length hLA protein. The confocal microscopy studies with fluoroprobe-labeled samples show that these proteins are internalized into the cells and found even in the nucleus only when they are complexed with OA. The HAMLET conjugated with a single biotin molecule will be a useful tool to identify the cellular components that are involved with it in the tumoricidal activity.

  11. Study of X-Ray and $\\gamma$-Ray Spectra from Antiprotonic Atoms at the Slowly Extracted Antiproton Beam of LEAR

    CERN Multimedia

    2002-01-01

    This experiment will study the X-ray spectra of antiprotonic atoms and the $\\gamma$ spectra of residual nuclei after the antiproton absorption. We intend to begin with measurements on selected isotopically pure targets. Strong interaction effects, the antiproton absorption and the atomic cascade are analysed through the measurement of energies, lineshapes, relative and absolute intensities of all observable lines. The experiments are continued to determine st in resolved fine structure levels and in different isotopes of the same element. Coincidence techniques may be applied. All components of the experimental set-up are already existing from previous experiments and we could begin the measurements with any slowly extracted beam of low energy at LEAR.

  12. AFSC/RACE/SAP/Urban: Golden King Crab tagging

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data is comprised of the records of individual male golden king crab (GKC) tagged at the Kodiak Laboratory. Initial size, shell condition and missing limbs was...

  13. 78 FR 59414 - Environmental Impact Statement; King County, Washington

    Science.gov (United States)

    2013-09-26

    ... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Environmental Impact Statement; King... prepare an environmental impact statement. SUMMARY: The Federal Highway Administration is issuing this notice to advise the public that an Environmental Impact Statement (EIS) will be prepared for a proposed...

  14. The King-Denborough syndrome in the paediatric patient.

    African Journals Online (AJOL)

    We describe the management of two children with a diagnosis of King Denborough syndrome. ... the anaesthetic management of two cases of KDS presenting for sur- .... al suggest that the syndrome represents a phenotype that is common to.

  15. The Influence of Martin Luther King on Education

    Science.gov (United States)

    Harper, Frederick D.

    1973-01-01

    In a sense, Martin Luther King was an educator whose students composed citizens of the United States, whose classroom encompassed the entire country, and whose course contents and lesson plans included civil rights, race relations, human rights, and love. (Author)

  16. Reflections on Cambridge: John Maynard Keynes at King's College Cambridge

    OpenAIRE

    Macfarlane, Alan

    2012-01-01

    .mp4 video file The economist John Maynard Keynes spent much of his life in Cambridge, connected to King's College. Alan Macfarlane reflects on a few aspects of his life and work. Filmed by Xu Bei in 2010

  17. Den radikale Kings skandinaviske drøm

    DEFF Research Database (Denmark)

    Brøndal, Jørn

    2013-01-01

    I dag forgudes Martin Luther King for sin racemæssige vision. Derimod aner de fleste amerikanere ikke noget om hans økonomiske ideer, og hvis de gjorde, ville mange af dem utvivlsomt affeje dem som alt for radikale......I dag forgudes Martin Luther King for sin racemæssige vision. Derimod aner de fleste amerikanere ikke noget om hans økonomiske ideer, og hvis de gjorde, ville mange af dem utvivlsomt affeje dem som alt for radikale...

  18. Human resources managers as custodians of the King III code

    Directory of Open Access Journals (Sweden)

    Frank de Beer

    2015-05-01

    Full Text Available The objective of this research was to perform an exploratory study on the knowledge and understanding of the King III code among Human Resources (HR managers in South African companies. The King III code is a comprehensive international corporate governance regime which addresses the financial, social, ethical and environmental practices of organisations. HR management plays a role in managing corporate governance by using the King III code as a guideline. The main research questions were: Does HR management know, understand, apply, and have the ability to use the King III code in terms of ethical decision-making? What role does HR management play in corporate governance? A random sample of available HR managers, senior HR consultants and HR directors was taken and semi-structured interviews were conducted. The results indicated that the respondents had no in-depth knowledge of the King III code. They did not fully understand the King III code and its implications nor did they use it to ensure ethical management. The themes most emphasised by the participants were: culture, reward and remuneration, policies and procedures and performance management. The participants emphasised the importance of these items  and HR’s role in managing them.

  19. King Saul’s mysterious malady

    Directory of Open Access Journals (Sweden)

    Gillian P. Williams

    2012-01-01

    Full Text Available This article investigates the ‘illness’ of King Saul (as narrated in the Old Testament. The ‘anti-Saul narrative’ states that ‘God’s spirit had left Saul’ and ‘an evil one had taken its place’ (1 Sm 16:14; also cf. e.g. of his behaviour in 1 Sm 19:24; 1 Sm 18:28−29. The latter years of Saul’s reign were marred by his pre-occupation with David’s growing popularity. He eventually became mentally unstable and suspected everyone of plotting against him. Saul’s battle against the Ammonites, as well as his last battle against the Philistines at Mount Gilboa, was fraught with difficulty. It is postulated that Saul experienced epileptic-like fits and assumedly suffered from some kind of ‘depression’ as a result of post-traumatic stress disorder (cf. 1 Sm 18:9; 1 Sm 18:28, 29; 1 Sm 19:24. This was possibly exacerbated by the enemy herem principle. Talmudic and other perspectives were also provided in the article where possible.

  20. Direct somatic embryogenesis in Swietenia macrophylla King

    Directory of Open Access Journals (Sweden)

    Raúl Collado

    2006-04-01

    Full Text Available Swietenia macrophylla King is difficult to be propagated by tissue culture and there is not an efficient system via organogenesis, due to problems of microbial contamination, phenolic oxidation and death of tissue in the phase of in vitro establishment of explants. In order to establish a protocol for obtaining somatic embryos, zygotic embryos were used as initial plant material. Three combinations of 2,4-D with kinetin were studied, to obtain the formation of somatic embryos. After six weeks of culture, the number of explants with high and low somatic embryogenesis frequency were determined. So that the somatic embryos in globular stage reach the final stages of torpedo and cotyledonal, these were placed in three treatments with 6-BAP (0.2, 0.4 y 0.6 mg.l-1. The number of somatic embryos that reached the torpedo and cotyledonal stages were evaluated after 30 days of culture. Results demonstrated that direct somatic embryogenesis from immature zygotic embryos is obtained in the culture medium composed by MS salts with 4.0 mg.l-1 of 2,4-D and 1.0 mg.l-1 of kinetin. Higher percentage of somatic embryos in cotiledonal stage (91.7 %, was obtained with 0.4 mg.l-1 of 6-BAP. Key word: forestry, growth regulator, mahogany, somatic embryo, tissue culture

  1. Comparison of the response of various TLDs to cosmic radiation and ion beams: Current results of the HAMLET project

    International Nuclear Information System (INIS)

    Bilski, P.; Berger, T.; Hajek, M.; Reitz, G.

    2011-01-01

    HAMLET is an European Commission research project aiming at optimal scientific exploitation of the data produced within the space experiment MATROSHKA. During phase 1 of this experiment a human phantom equipped with several thousands of radiation detectors (mainly TLDs) was exposed outside the International Space Station for 1.5 years. Besides the measurements realized in Earth orbit, the HAMLET project includes also a ground-based program of intercomparison of detector response to high-energy ion beams. Within the paper, the relative response of main glow-curve peaks of various TLDs (mostly based on LiF) used in frame of the MATROSHKA experiment by three laboratories (DLR Cologne, ATI Vienna and IFJ Krakow) for radiation in space and several ion beams, has been compared. For LiF:Mg,Ti detectors a very good agreement between results obtained by the three laboratories was observed, both for space and accelerator-based exposures. This should be considered a remarkable result, taking into account that the studied TLDs originated from six different batches, manufactured by two producers exploiting different production techniques and were processed by three laboratories, using significantly different protocols (annealing, readout, calibration, glow-curve analysis). Another type of TL detectors, LiF:Mg,Cu,P, was found to show response to cosmic radiation lower than that of LiF:Mg,Ti by 5%–18%.

  2. Calibration of solid state nuclear track detectors at high energy ion beams for cosmic radiation measurements: HAMLET results

    International Nuclear Information System (INIS)

    Szabó, J.; Pálfalvi, J.K.

    2012-01-01

    The MATROSHKA experiments and the related HAMLET project funded by the European Commission aimed to study the dose burden of the crew working on the International Space Station (ISS). During these experiments a human phantom equipped with several thousands of radiation detectors was exposed to cosmic rays inside and outside the ISS. Besides the measurements realized in Earth orbit, the HAMLET project included also a ground-based program of calibration and intercomparison of the different detectors applied by the participating groups using high-energy ion beams. The Space Dosimetry Group of the Centre for Energy Research (formerly Atomic Energy Research Institute) participated in these experiments with passive solid state nuclear track detectors (SSNTDs). The paper presents the results of the calibration experiments performed in the years 2008–2011 at the Heavy Ion Medical Accelerator (HIMAC) of the National Institute of Radiological Sciences (NIRS), Chiba, Japan. The data obtained serve as update and improvement for the previous calibration curves which are necessary for the evaluation of the SSNTDs exposed in unknown space radiation fields.

  3. Calibration of solid state nuclear track detectors at high energy ion beams for cosmic radiation measurements: HAMLET results

    Energy Technology Data Exchange (ETDEWEB)

    Szabo, J., E-mail: julianna.szabo@energia.mta.hu [Hungarian Academy of Sciences, Centre for Energy Research, Konkoly Thege Miklos ut 29-33, 1525 Budapest 114, P.O. Box 49 (Hungary); Palfalvi, J.K. [Hungarian Academy of Sciences, Centre for Energy Research, Konkoly Thege Miklos ut 29-33, 1525 Budapest 114, P.O. Box 49 (Hungary)

    2012-12-01

    The MATROSHKA experiments and the related HAMLET project funded by the European Commission aimed to study the dose burden of the crew working on the International Space Station (ISS). During these experiments a human phantom equipped with several thousands of radiation detectors was exposed to cosmic rays inside and outside the ISS. Besides the measurements realized in Earth orbit, the HAMLET project included also a ground-based program of calibration and intercomparison of the different detectors applied by the participating groups using high-energy ion beams. The Space Dosimetry Group of the Centre for Energy Research (formerly Atomic Energy Research Institute) participated in these experiments with passive solid state nuclear track detectors (SSNTDs). The paper presents the results of the calibration experiments performed in the years 2008-2011 at the Heavy Ion Medical Accelerator (HIMAC) of the National Institute of Radiological Sciences (NIRS), Chiba, Japan. The data obtained serve as update and improvement for the previous calibration curves which are necessary for the evaluation of the SSNTDs exposed in unknown space radiation fields.

  4. Hamlet e a hermenêutica: Das muitas interpretações da triste estória do príncipe da Dinamarca

    Directory of Open Access Journals (Sweden)

    Marcelo Bolshaw Gomes

    2016-08-01

    Full Text Available Analisa-se aqui quatro adaptações de Hamlet, de William Shakespeare, para o cinema: Laurence Olivier (1948; Franco Zeffirelli (1990; Kenneth Branagh (1996 e Michael Almereyda (2000. E se discutem as relações da narrativa com a psicanálise e com a hermenêutica.

  5. The Breach and the Observance : Theatre retranslation as a strategy of artistic differentiation, with special reference to retranslations of Shakespeare's Hamlet (1777-2001)

    NARCIS (Netherlands)

    Mathijssen, J.W.

    2007-01-01

    The subject of "The Breach and the Observance" is retranslation for the theatre. Besides offering a model that incorporates the findings of previous scholarship, it casts new light on the motivation behind retranslation, using the case of translations of Shakespeare's Hamlet on the Dutch stage.

  6. Thermal characteristics of soil and water during summer at King Sejong Station, King George Island, Antarctica

    Science.gov (United States)

    Lim, H. S.; Lee, J. Y.; Yoon, H.

    2016-12-01

    Soil temperatures, water temperatures, and weather parameters were monitored at a variety of locations in the vicinity of King Sejong station, King George Island, Antarctica, during summer 2010-2011. Thermal characteristics of soil and water were analysed using time-series analyses, apparent thermal diffusivity (ATD), and active layer thickness. The temperatures of pond water and nearby seawater showed the distinctive diurnal variations and correlated strongly with solar radiation (r = 0.411-0.797). Soil temperature (0.1-0.3 m depth) also showed diurnal fluctuations that decreased with depth and were directly linked to air temperature (r = 0.513-0.783) rather than to solar radiation; correlation decreased with depth and the time lag in the response increased by 2-3 hours per 0.1 m of soil depth. Owing to the lack of snow cover, summertime soil temperature was not decoupled from air temperature. Estimated ATD was between 0.022 and 29.209 mm2/sec, showed temporal and spatial variations, and correlated strongly with soil moisture content. The maximum estimated active layer thickness in the study area was a 41-70 cm, which is consistent with values reported in the previous work.

  7. The 'Byzantinisms' of king Stefan Radoslav

    Directory of Open Access Journals (Sweden)

    Maksimović Ljubomir

    2009-01-01

    Full Text Available The life-style and politics of Stefan Radoslav bear the mark of activities that indicated his special attachment to the Byzantine world. These activities were prompted by a combination of ideological ambitions and political reality, but they were not in keeping with the modest achievements of Radoslav's reign. Moreover, most of these activities belong to the time when Radoslav was heir to the throne. There is no doubt that Stefan Nemanjić the Grand Zhupan and subsequently the first crowned king, had exclusive connections with the Byzantine dynasty of the Angeloi, especially with the emperor Alexios III (1195-1203. In that context, the donor's inscription in the basic ring of the dome in the Church of the Mother of God in Studenica (1208, in which his father Stefan Nemanja, is mentioned as (former 'veleslavni gospodin vse srbske zemlje veli(ki župan i svat cara grčkog kir Alesija', is quite indicative. This ideological construction would acquire a contour in reality by means of a political marriage with one of the female offspring of Angeloi lineage, which would represent an alternative solution to Stefan's failed marriage with Eudocia, daughter of the emperor Alexios. Instead, several years elapsed in waging war with the Latins, the Bulgarians and the State of Epiros. However, efforts to create firmer, more tangible ties with the Angeloi dynasty from Epiros were not forgotten. Therefore, the Serbian monarch brought his eldest son Radoslav into play, intending to have him act as a link with the Angeloi bloodline. As a result of all this, the final attempt to have Radoslav become the husband of a princess from the Angelos dynasty is not surprising. At the end of 1219 or the beginning of 1220, he married Anna Doukaina, the daughter of the epirotic ruler Theodore I Angelos Doukas Komnenos, which at that point represented a marriage connection of the highest possible level between two ruling houses. Stefan's insistence on Serbia acquiring a stake

  8. Water resources of King County, Washington

    Science.gov (United States)

    Richardson, Donald; Bingham, J.W.; Madison, R.J.; Williams, R.

    1968-01-01

    Although the total supply of water in King County is large, water problems are inevitable because of the large and rapidly expanding population. The county contains a third of the 3 million people in Washington, most of the population being concentrated in the Seattle metropolitan area. King County includes parts of two major physiographic features: the western area is part of the Puget Sound Lowland, and the eastern area is part of the Cascade Range. In these two areas, the terrain, weather, and natural resources (including water) contrast markedly. Average annual precipitation in the county is about 80 inches, ranging from about 30 inches near Puget Sound to more than 150 inches in parts of the Cascades. Annual evapotranspiration is estimated to range from 15 to 24 inches. Average annual runoff ranges from about 15 inches in the lowlands to more than 100 inches in the mountains. Most of the streamflow is in the major basins of the county--the Green-Duwamish, Lake Washington, and Snoqualmie basins. The largest of these is the Snoqualmie River basin (693 square miles), where average annual runoff during the period 1931-60 was about 79 inches. During the same period, annual runoff in the Lake Washington basin ( 607 square miles) averaged about 32 inches, and in the Green-Duwamish River basin (483 square miles), about 46 inches. Seasonal runoff is generally characterized by several high-flow periods in the winter, medium flows in the spring, and sustained low flows in the summer and fall. When floods occur in the county they come almost exclusively between October and March. The threat of flood damage is greatest on the flood plaits of the larger rivers, but in the Green-Duwamish Valley the threat was greatly reduced with the completion of Howard A. Hanson Dam in 1962. In the Snoqualmie River basin, where no such dam exists, the potential damage from a major flood increases each year as additional land is developed in the Snoqualmie Valley. 0nly moderate amounts of

  9. Correction to Kreuzbauer, King, and Basu (2015).

    Science.gov (United States)

    2015-08-01

    Reports an error in "The Mind in the Object-Psychological Valuation of Materialized Human Expression" by Robert Kreuzbauer, Dan King and Shankha Basu (Journal of Experimental Psychology: General, Advanced Online Publication, Jun 15, 2015, np). In the article the labels on the X-axis of Figure 1 "Remove Variance" and "Preserve Variance" should be switched. (The following abstract of the original article appeared in record 2015-26264-001.) Symbolic material objects such as art or certain artifacts (e.g., fine pottery, jewelry) share one common element: The combination of generating an expression, and the materialization of this expression in the object. This explains why people place a much greater value on handmade over machine-made objects, and originals over duplicates. We show that this mechanism occurs when a material object's symbolic property is salient and when the creator (artist or craftsman) is perceived to have agency control over the 1-to-1 materialized expression in the object. Coactivation of these 2 factors causes the object to be perceived as having high value because it is seen as the embodied representation of the creator's unique personal expression. In 6 experiments, subjects rated objects in various object categories, which varied on the type of object property (symbolic, functional, aesthetic), the production procedure (handmade, machine-made, analog, digital) and the origin of the symbolic information (person or software). The studies showed that the proposed mechanism applies to symbolic, but not to functional or aesthetic material objects. Furthermore, they show that this specific form of symbolic object valuation could not be explained by various other related psychological theories (e.g., uniqueness, scarcity, physical touching, creative performance). Our research provides a universal framework that identifies a core mechanism for explaining judgments of value for one of our most uniquely human symbolic object categories. (c) 2015 APA, all

  10. Primary hyperparathyroidism: King Khalid University Hospital experience

    International Nuclear Information System (INIS)

    Fouda, Mona A.

    1999-01-01

    This study was conducted to examine the prevalence, mode of presentationand management of primary hyperparathyroidism in one of the major hospitalsin Saudi Arabia. This was a retrospective analysis of 24 cases of primaryhyperparathyroidism comprising of 21 females and three males, who were seenat King Khalid University Hospital over a period of 16 years from 1982 untilDecember 1997. The prevalence of disease was estimated to be estimated to be11.34 per 100,000 hospital population. The majority of patients presentedwith musculoskeletal complaints (62%-67%) and/or renal complications were(58%). Hyperclacemia was seen in 92% of the cases. Serum PTH was availablefor 21 patients and 20 had significantly elevated levels. Fifty percent ofthe patients had features of hyperparathyroid bone disease on plane x-ray,while 79% showed osteopenia of the femoral neck and dual x-rayabsorptiometry, and almost all the patients had lumbar osteopenia. Fiftypercent of the patients had features of metabolic bone disease on bone scan.Thallium -technetium subtraction studies proved to be the most reliable tool,with 83% sensitivity of 55%. CT scan of the neck was attempted in only inseven patients (29%), with a sensitivity of 86%. Twenty-one patients (87.5%)underwent surgical exploration and removal of the parathyroid adenoma. Singleparathyroid adenoma was identified in 85% of the cases, 5% had multipleadenomas and 5% had hyperplasia of the parathyroid gland. Our results showedthat primary hyperparathyroidism is not rare disease in Saudi Arabia. It hastendency for late presentation with complications. We believe that routinescreening for calcium, and early identification of such cases, are warrantedto reduce the morbidity of this easily treatable disorder. (author)

  11. C. Judson King of UC Berkeley

    Energy Technology Data Exchange (ETDEWEB)

    Prausnitz, John

    2005-06-01

    In the middle of the UC Berkeley campus, next to the Main Library, South Hall is the last surviving building from the original campus, founded about 135 years ago. A tiny tree-shaded appendix to this venerated classical building houses Berkeley's Center for Studies in Higher Education, directed by C. Judson King, former Provost and Senior Vice President--Academic Affairs of the ten-campus University of California and long-time Professor of Chemical Engineering at Berkeley. Jud came to Berkeley in 1963 as assistant professor of chemical engineering, following receipt of a doctor's degree from MIT and a subsequent short appointment as director of the MIT chemical engineering practice school station at what was then Esso (now Exxon) in New Jersey. His undergraduate degree is from Yale. Starting with his MIT doctoral dissertation on gas absorption, Jud has devoted much of his professional career to separation processes. His teaching and research activities have been primarily concerned with separation of mixtures with emphasis on liquid-liquid extraction and drying. As a consultant to Procter and Gamble, he contributed to the technology of making instant coffee. His life-long activities in hiking and camping stimulated Jud's interest in the manufacture of freeze-dried foods (e.g. turkey meat) to minimize the weight of his hiking back-pack. Jud is internationally known not only for his many research publications but even more, for his acclaimed textbook ''Separation Processses'' (McGraw-Hill, second edition 1980) that is used in standard chemical engineering courses in the US and abroad.

  12. [A study of treatise on medicine by King Sejo].

    Science.gov (United States)

    Hwang, Im-kyung; Hwang, Sang-lk

    2003-12-01

    This paper explores historical backgrounds and contents of Treatise on Medicine written by King Sejo (r. 1455-1468) including his views on traditional medicine and pharmacy in the early Chosen period. The Treatise declared by King Sejo in 1463 has been considered as an important and unique manual of medicine because it was the exclusive example written by the king of Chosen. It was the King Sejo' s era when the medical milieu in both social and medical aspects was highly encouraged thanks to the previous achievements by King Sejong the Great (r.1418-1450). King Sejo, in particular, who was much interested in practical learning called 'Miscellaneous Studies', emphasized on court medicine. His writing can be understood in such historical frame. Another reason why he wrote the Treatise can be said that he felt necessary for establishing the medical ethic codes for inefficient court medicine-officials. In personal background, he tried to find available remedies since he had been suffered from some chronic diseases. The contents of the Treatise can be broadly fallen to the clinical and ethical aspects. In the former one, the Treatise focuses on treatment without hesitation through the sharp and exact diagnosis by medical doctors. In the latter one, eight categories of medical doctors are discussed according to their moral degrees: sim'eui, sik'eui, yak'eui, hon'eui, kwang eui, mang'eui, sa'eui, and sal'eui. Finally, musim' ji-eui was supplemented. Among them, sal'eui, medicine-official lacking both medical ability and ethical attitude, was classified as the lowest degree; sim'eui, medicine-official sincerely making his all efforts for patients, was thought to be a paragon of medical morality. In conclusion, the Treatise on Medicine by King Sejo played an important role as a manual for the principle of medical practice and for the instruction to enhance ethical attitude among medicine-officials.

  13. Rama in the royal title of the Hungarian kings

    Directory of Open Access Journals (Sweden)

    Živković Tibor D.

    2004-01-01

    Full Text Available The region (župa of Rama was enlisted in the official title of the Hungarian kings around 1138, as it is known from an official document. The exact answer to the question under which circumstances it happened has never been reached. It is most probable that Rama was not just other name for Bosnia as it was proposed in historiography, neither was a part of Bosnia conquered by military action of the Hungarian king around 1135. Having in mind that Rama was a part of the principality of Raška during the Early Middle Ages, it is quite possible that Rama became part of the official title of the Hungarian kings through some direct connections between ruling families of Hungary and Raška. The most probable answer could be reached through the examination of these relations. Namely, a daughter of Raška's župan, Uroš I, Helena, was married to the Hungarian crown prince Bela in 1129, when Rama was, most probably, part of Helena's dowry. When the crown prince became king of Hungary in 1131, Rama was included in his royal title. Later on during the Middle Ages Rama became part of Bosnia giving ground to the Hungarian kings to claim whole Bosnia as their heritage. .

  14. Sulfur and Oxygen Isotopic Composition of Sulfate in the Fresh Water, King Sejong Station, King George Island, Antarctica

    Science.gov (United States)

    Kim, M.; Lee, I.; Lee, J.; Park, B.; Mayer, B.; Kaufman, A. J.; Park, S.; Kim, G.; Lee, K.

    2008-12-01

    Isotopic compositions of sulfur (δ34S) and oxygen (δ18O) were measured for the sulfate of the fresh water near the King Sejong Station, King George Island, Antarctica. Sejong station is located in the Barton peninsular of the King George Island. The geology around King Sejong station mainly composed of basalt-andesite, quart monzodiorite, and granodiorite. Lapilli tuff, conglomerate, sandstone, and siltstone occur along the southern and eastern shore of the Barton peninsula. Lapilli tuff also occurs on the highland located on southeastern part of the Barton peninsula. The δ34S values of sulfate extracted from fresh water samples at King Sejong Station range from 13.7 to 16.3 per mil excluding 1 sample. These sulfur values are very narrow in their range compared with those from anthropogenic sources. These sulfur values are 5 to 7 per mil lower than those of typical present seawater. Considering the rocks occurring near the King Sejong station, these sulfur isotopic values do not seem to be related to any evaporites of certain age. In Antarctic region the natural source of sulfate dissolved in water could be originated from marine biogenic source (DMS), sea-salt, volcanic source, or other continental sources. Most of the δ34S values of sulfate at King Sejong station seems to indicate the dominance of marine biogenic origin for the source of sulfur. The δ18O values of sulfate extracted from fresh water samples at King Sejong Station range from 1.9 to 6.4 per mil excluding 1 sample. These oxygen isotope values are lower than those of the sulfate in the present seawater by 6 per mil. However, both sulfur and oxygen isotope values strongly represent the influence of the seawater sulfate. One sample have 2.6 and -1.1 per mil in its δ34S and δ18O values, respectively, that are quite different from the isotopic values of other samples. This sample was collected in the highland far from the King Sejong station. Therefore this sample might reflect the composition of

  15. Black swans and dragon kings: A unified model

    Science.gov (United States)

    Eliazar, Iddo

    2017-09-01

    The term “black swan” is a metaphor for outlier events whose statistics are characterized by Pareto's Law and by Zipf's Law; namely, statistics governed by power-law tails. The term “dragon king” is a metaphor for a singular outlier event which, in comparison with all other outlier events, is in a league of its own. As an illustrative example consider the wealth of a family that is sampled at random from a medieval society: the nobility constitutes the black-swan category, and the royal family constitutes the dragon-king category. In this paper we present and analyze a dynamical model that generates, universally and jointly, black swans and dragon kings. According to this model, growing from the microscopic scale to the macroscopic scale, black swans and dragon kings emerge together and invariantly with respect to initial conditions.

  16. Dr. Martin Luther King, Jr. as Spiritual Leader

    Directory of Open Access Journals (Sweden)

    Andrea Pierce

    2013-09-01

    Full Text Available The purpose of this paper is to explore Dr. Martin Luther King Jr.’s spiritual leadership through his “I Have a Dream” speech. The paper explores the three characteristics of spiritual leadership as posed by Fry’s (2003 spiritual leadership theory: vision, hope/faith and altruistic love. The research draws upon these characteristics through qualitative content analysis of Dr. Martin Luther King Jr.’s “I Have a Dream” speech to illustrate Dr. King’s leadership as that of a spiritual leader. The research advances the spiritual leadership theory by establishing Dr. Martin Luther King Jr. as a spiritual leader. Through the illustration of Dr. King’s spiritual leadership, the characteristics of a spiritual leader are given tangible understanding.

  17. The Unbearable Lightness of Memory: From Hamlet, Prince of Denmark to Jorge Luis Borges’ Shakespeare’s Memory

    Directory of Open Access Journals (Sweden)

    Raducanu Adriana

    2015-12-01

    Full Text Available The Romantic poet Novalis once rhetorically asked: “Where are we really going?” “Always home.” For a Shakespearean scholar like Borges’ Sörgel in “Shakespeare’s Memory”, the path towards “home” turns out to be the exploration of a most unusual gift, the very memory of the great Elizabethan. The process is similar although not identical in scope to Hamlet’s attempt to realign time through keeping alive the memory of his murdered father. My aim in this paper is to explore the process of preserving memory and its relation to identity, mourning and dread in “Hamlet, Prince of Denmark” and Borges’ “Shakespeare’s Memory”. The theoretical framework is defined by the concept of “eternal return”, as examined by Nietzsche and Mircea Eliade.

  18. Structural characterization of more potent alternatives to HAMLET, a tumoricidal complex of α-lactalbumin and oleic acid.

    Science.gov (United States)

    Nemashkalova, Ekaterina L; Kazakov, Alexei S; Khasanova, Leysan M; Permyakov, Eugene A; Permyakov, Sergei E

    2013-09-10

    HAMLET is a complex of human α-lactalbumin (hLA) with oleic acid (OA) that kills various tumor cells and strains of Streptococcus pneumoniae. More potent protein-OA complexes were previously reported for bovine α-lactalbumin (bLA) and β-lactoglobulin (bLG), and pike parvalbumin (pPA), and here we explore their structural features. The concentration dependencies of the tryptophan fluorescence of hLA, bLA, and bLG complexes with OA reveal their disintegration at protein concentrations below the micromolar level. Chemical cross-linking experiments provide evidence that association with OA shifts the distribution of oligomeric forms of hLA, bLA, bLG, and pPA toward higher-order oligomers. This effect is confirmed for bLA and bLG using the dynamic light scattering method, while pPA is shown to associate with OA vesicles. Like hLA binding, OA binding increases the affinity of bLG for small unilamellar dipalmitoylphosphatidylcholine vesicles, while pPA efficiently binds to the vesicles irrespective of OA binding. The association of OA with bLG and pPA increases their α-helix and cross-β-sheet content and resistance to enzymatic proteolysis, which is indicative of OA-induced protein structuring. The lack of excess heat sorption during melting of bLG and pPA in complex with OA and the presence of a cooperative thermal transition at the level of their secondary structure suggest that the OA-bound forms of bLG and pPA lack a fixed tertiary structure but exhibit a continuous thermal transition. Overall, despite marked differences, the HAMLET-like complexes that were studied exhibit a common feature: a tendency toward protein oligomerization. Because OA-induced oligomerization has been reported for other proteins, this phenomenon is inherent to many proteins.

  19. King's theory of goal attainment: exploring functional status.

    Science.gov (United States)

    Caceres, Billy A

    2015-04-01

    Imogene King's Theory of Goal Attainment provides a schema for nurses interested in functional status. However, the lack of a uniform definition for functional status has hindered development of a concise understanding of this phenomenon. Functional status is particularly important to nurses who are concerned with the safety and wellbeing of clients. With healthcare's increased focus on client-family-centered care it is important to develop innovative approaches for evaluating functional status that incorporate the client-family perspective. King's focus on mutual decision-making is an underutilized resource that can provide great insight into the study and understanding of functional status. © The Author(s) 2015.

  20. The leaders King Sverre and King Haakon : analysis of King Sverre Sigurdsson and King Haakon Haakonsson in Sverris Saga and Haakonar Saga Haakonarsonar through Max Weber's and John Gardner's models

    OpenAIRE

    Osornio, Ismael Jose Duran

    2004-01-01

    The leadership of the Norwegian Kings during the Medieval ‘Civil War’ plays a prominent part in social, political and economical life in high Medieval Norway. The objective of the present dissertation discusses how King Sverre Sigurdsson (1177-1202) and Haakon Haakonsson (1217-1263) are depicted in their Sagas. The work will be focus on four analytical tools: 1. The Kings’ Charisma; 2. The Kings’ Personal Abilities; 3. The Kings’ Bureaucracy; 4. The King’s closest Fellows. The thesis goal wil...

  1. Local seismic activity monitored at King Sejong Station, Antarctica

    OpenAIRE

    Lee,Duk Kee; Kim,Yea Dong; Nam,Sang Heon; Jin,Young Keun

    1998-01-01

    Source location estimation from single station earthquake data collected at King Sejong Station (62°13'3l"N, 58°47'07"W) from 1995 to 1996 provides seismic activity around King Sejong Station. Analysis of local events, less than 1.5°in angular epicentral distance, finds epicenters located near the Shackleton Fracture Zone, the South Shetland Platform, Deception Island, and North Bransfield Basin. Estimated magnitudes range from 2.2 to 4.5 on the Richter scale, averaging 4.0 in North Bransfiel...

  2. 45 King: A Story of the Southern Home

    OpenAIRE

    Deluca, Paul Matthew Webb

    2014-01-01

    The house at 45 King St. in Charleston, South Carolina is more than a home. It is a story of the home. A story told through history, through a vision exhibited in architectural drawings, and through the social heritage closest to my heart. 45 King is a story for the South; the story of its grandeur, its climate, its natural beauty, its hospitality, its comfort, and its veils. It is a story that was told yesterday and one that is still told today. Like an oral history, the telling of it may...

  3. Dragon-Kings, Black-Swans and Prediction (Invited)

    Science.gov (United States)

    Sornette, D.

    2010-12-01

    Extreme fluctuations or events are often associated with power law statistics. Indeed, it is a popular belief that "wild randomness'' is deeply associated with distributions with power law tails characterized by small exponents. In other words, power law tails are often seen as the epitome of extreme events (the "Black Swan'' story). Here, we document in very different systems that there is life beyond power law tails: power laws can be superseded by "dragon-kings'', monster events that occur beyond (or changing) the power law tail. Dragon-kings reveal hidden mechanisms that are only transiently active and that amplify the normal fluctuations (often described by the power laws of the normal regime). The goal of this lecture is to catalyze the interest of the community of geophysicists across all fields of geosciences so that the "invisible gorilla" fallacy may be avoided. Our own research illustrates that new statistics or representation of data are often necessary to identify dragon-kings, with strategies guided by the underlying mechanisms. Paradoxically, the monsters may be ignored or hidden by the use of inappropriate analysis or statistical tools that amount to cut a mamooth in small pieces, so as to lead to the incorrect belief that only mice exist. In order to stimulate further research, we will document and discuss the dragon-king phenomenon on the statistics of financial losses, economic geography, hydrodynamic turbulence, mechanical ruptures, avalanches in complex heterogeneous media, earthquakes, and epileptic seizures. The special status of dragon-kings open a new research program on their predictability, based on the fact that they belong to a different class of their own and express specific mechanisms amplifying the normal dynamics via positive feedbacks. We will present evidence of these claims for the predictions of material rupture, financial crashes and epileptic seizures. As a bonus, a few remarks will be offered at the end on how the dragon-king

  4. An Uncommon Complication with a Supraglottic Airway: The King LT.

    Science.gov (United States)

    Brown, Sara; Cherian, Verghese T; Greco, Katherine; Mets, Elbert; Budde, Arne

    2016-02-15

    General anesthesia was administered in an 18-year-old man for removal of hardware from his right knee using a King Laryngeal Tube supraglottic airway. An hour after extubation, he reported inability to swallow with no respiratory distress. Examination showed an edematous uvula, which took 3 days to subside with anti-inflammatory medication. During the positioning of the King Laryngeal Tube, it was pulled back to ensure adequate ventilation. The inflated cuff could have dragged the uvula and folded it on itself, leading to venous congestion and edema.

  5. Study of $ \\bar{p} $ and $ \\bar{n} $ annihilations at LEAR with OBELIX, a large acceptance and high resolution detector based on the Open Axial Field Spectrometer

    CERN Multimedia

    2002-01-01

    % PS201 Study of $\\bar{p}$ and $\\bar{n}$ annihilations at LEAR with OBELIX, a large acceptance and high resolution detector based on the Open Axial Field Spectrometer \\\\ \\\\OBELIX is designed to study exclusive final states of antiproton and antineutron annihilations at low energies with protons and nuclei. \\\\ \\\\The physics motivations of the experiment are:\\\\ \\\\\\begin{itemize} \\item (gg, ggg), hybrids ($ q \\bar{q} g $), multiquarks ($ q q \\bar{q} \\bar{q} $) and light mesons ($ q \\bar{q} $) produced in $ N \\bar{N} $ annihilations and study of their spectroscopy and decays. Also broad structures will be searched for by comparing identical decay modes in exclusive final states of the same type occuring from initial states with different angular momentum or isospin. \\item Study of the dynamics of $ N \\bar{N} $ interactions and of the dependence of the final and intermediate resonant states of annihilation upon the quantum numbers of the initial $ N \\bar{N} $ state (angular momentum: S and P-wave in $\\bar{p}p $ at...

  6. AFSC/RACE/SAP/Long: Data from: Embryo development in golden king crab, Lithodes aequispina.

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data from this study, describes embryo development in Golden king crab, Lithodes aequispinus. Six female multiparous golden king crab were captured from the...

  7. Martin Luther King Jr. contest winning posters to be displayed in downtown Blacksburg

    OpenAIRE

    Shannon, Kelly Baker

    2010-01-01

    Each year as part of the Martin Luther King Jr. celebration at Virginia Tech area kindergarten through 12th grade students are invited to participate in the annual Martin Luther King Jr. poster contest.

  8. Matthew's Messianic Shepherd-king: In search of “the lost sheep of ...

    African Journals Online (AJOL)

    p1243322

    the Messianic Shepherd-King expectation with its attending expectations for territorial ... Messianic Shepherd-King: In Search of the Lost Sheep of the House of Israel. September. 2007. Berlin: De Gruyter. ...... Exile in the early. Persian Period”.

  9. 3 CFR 8340 - Proclamation 8340 of January 15, 2009. Martin Luther King, Jr., Federal Holiday, 2009

    Science.gov (United States)

    2010-01-01

    ... Proclamation 8340 of January 15, 2009 Proc. 8340 Martin Luther King, Jr., Federal Holiday, 2009By the President of the United States of America A Proclamation On the Martin Luther King, Jr., Federal Holiday, we... Constitution and laws of the United States, do hereby proclaim January 19, 2009, as the Martin Luther King, Jr...

  10. 75 FR 3839 - Martin Luther King, Jr., Federal Holiday, 2010

    Science.gov (United States)

    2010-01-22

    ... Part III The President Proclamation 8473--Martin Luther King, Jr., Federal Holiday, 2010 Proclamation 8474--Religious Freedom Day, 2010 Notice of January 20, 2010--Continuation of the National... only by the power of his words, which still call on us to perfect those sacred ideals enshrined in our...

  11. International education, the internet, and the Three Kings experiment

    NARCIS (Netherlands)

    Kooijman, J.; Davies, J.; Berg-Cross, L.; Copier, L.; Asby, A.

    2004-01-01

    The current project linked students in three universities in a guided discussion of the movie, Three Kings. The goals were to assess the viability of having students from three different courses, in three different universities, in three different countries find common ground to have intellectual

  12. Littoral Encounters : The Shore as Cultural Interface in King Horn

    NARCIS (Netherlands)

    Sobecki, Sebastian

    2006-01-01

    1. III * Later Medieval: Excluding Chaucer -- Brown et al., 10.1093 ... ... between the Saracens and the londisse men allied to the protagonist (' Littoral Encounters: the Shore as Cultural Interface in King Horn', Al-Mas a ... www.ywes.oxfordjournals.org/cgi/content/full/man0092 2.Murray, Alan V.

  13. Evaluation of medical consultation letters at King Fahd Hospital, Al ...

    African Journals Online (AJOL)

    Evaluation of medical consultation letters at King Fahd Hospital, Al Hufuf, Saudi Arabia. Hamed Abd Allah Al Wadaani, Magdy Hassan Balaha. Abstract. Background: In surgical wards, it is of paramount importance to communicate with other health care providers, mostly physicians, referring patients to them for their ...

  14. The Institute of Epileptology of King's College, University of London.

    Science.gov (United States)

    Reynolds, E H

    1995-01-01

    The Institute of Epileptology of King's College, London has arisen from need and from opportunity. The need is due to the relative neglect nationally and internationally of the most common serious brain disorder with important physical, psychological, and social complications. The relative neglect is reflected in services, research, charitable donations, public profile, and stigma and in a serious lack of professional education. The opportunity arose because of the existence in several medical institutions at Denmark Hill, London, of a group of medical and related colleagues with a special interest covering almost every aspect of this multidisciplinary disorder who agreed to combine their expertise in this initiative. The idea was born and developed in 1991-1992 and was supported by all the parent institutions: The Maudsley and King's College Hospitals, St. Piers Lingfield, The Institute of Psychiatry, King's College School of Medicine and Dentistry, and the School of Life, Basic Medical and Health Sciences, all under the umbrella of King's College, University of London. Further stimulus and help came from a group of dedicated supporters in private and public life. There are three strands to this initiative: (a) a charity, The Fund for Epilepsy; (b) the clinical Centre for Epilepsy, which was formally opened at the Maudsley Hospital in July 1994; and (c) the academic Institute of Epileptology for research and teaching, which was launched on November 15, 1994.

  15. Ornamental colors reveal age in the king penguin

    NARCIS (Netherlands)

    Nicolaus, Marion; Le Bohec, Celine; Nolan, Paul M.; Gauthier-Clerc, Michel; Le Maho, Yvon; Komdeur, Jan; Jouventin, Pierre

    2007-01-01

    We investigated whether delayed plumage maturation occurred in king penguins (Aptenodytes patagonicus). Therefore we examined the relationships between age and sex on spectral properties and size of two colored plumage patches and a UV-reflective beak spot, using known-age cohorts. Unlike the

  16. Evolution of king crabs from hermit crab ancestors

    Science.gov (United States)

    Cunningham, C. W.; Blackstone, N. W.; Buss, L. W.

    1992-02-01

    KING crabs (Family Lithodidae) are among the world's largest arthropods, having a crab-like morphology and a strongly calcified exoskeleton1-6. The hermit crabs, by contrast, have depended on gastropod shells for protection for over 150 million years5,7. Shell-living has constrained the morphological evolution of hermit crabs by requiring a decalcified asymmetrical abdomen capable of coiling into gastropod shells and by preventing crabs from growing past the size of the largest available shells1-6. Whereas reduction in shell-living and acquisition of a crab-like morphology (carcinization) has taken place independently in several hermit crab lineages, and most dramatically in king crabs1-6, the rate at which this process has occurred was entirely unknown2,7. We present molecular evidence that king crabs are not only descended from hermit crabs, but are nested within the hermit crab genus Pagurus. We estimate that loss of the shell-living habit and the complete carcinization of king crabs has taken between 13 and 25 million years.

  17. The King-Denborough syndrome in the paediatric patient. | Maharaj ...

    African Journals Online (AJOL)

    We describe the management of two children with a diagnosis of King Denborough syndrome. The first case is that of a 23-month-old term male infant requiring repair of a cleft palate. After flushing the anaesthetic machine, infusions of remifentanil at 0.25 μ/kg/min and propofol at 12 mg/kg/hr were commenced. These were ...

  18. Contrapuntal Significations in Wole Soyinka's Death and the King's ...

    African Journals Online (AJOL)

    Wole Soyinka's Death and the King's Horseman has been widely acclaimed as a great example of African tragedy. It is, in fact, the dramatic aggregation of Soyinka's treatise in Myth, Literature and the African World. Hence, the play is most often 'read' in the lights of its 'difference' from western notions of the tragic, the place ...

  19. Validation of the King's Health Questionnaire for South Africa in ...

    African Journals Online (AJOL)

    Objective. To validate the King's Health Questionnaire for urinary incontinence in the local South African English, Afrikaans and isiXhosa female community. Design. A cohort analytical study. Setting and subjects. The study utilised a sample of convenience. Women with urinary incontinence attending the gynaecology clinic ...

  20. Articulating nurse practitioner practice using King's theory of goal attainment.

    Science.gov (United States)

    de Leon-Demare, Kathleen; MacDonald, Jane; Gregory, David M; Katz, Alan; Halas, Gayle

    2015-11-01

    To further understand the interactions between nurse practitioners (NPs) and patients, King's nursing theory of goal attainment was applied as the conceptual framework to describe the interactions between NPs and patients in the primary care setting. Six dyads of NPs and their patients were video- and audio-taped over three consecutive clinic visits. For the purposes of this arm of the study, the audio-taped interactions were transcribed and then coded using King's concepts in her theory of goal attainment. King's theory was applicable to describe NP practice. King's concepts and processes of nurse-patient interactions, such as disturbances, mutual goal setting, and transactions, were observed in NP-patient interactions. Disturbances during clinical encounters were essential in the progression toward goal attainment. Elements, such as social exchange, symptom reporting, role explanation, and information around clinical processes facilitated relationship building. NPs as practitioners need to be reflective of their own practice, embrace disturbances in the clinical encounter, and attend to these as opportunities for mutual goal setting. ©2015 American Association of Nurse Practitioners.

  1. Mutual mate choice for olorful traits in King Penguins

    NARCIS (Netherlands)

    Nolan, Paul M.; Dobson, F. Stephen; Nicolaus, Marion; Karels, Tim J.; McGraw, Kevin J.; Jouventin, Pierre

    While studies of mate choice based on male color pattern are ubiquitous, studies of mate choice based on ornamental color traits in sexually monomorphic species are less common. We conducted manipulative field experiments on two color ornaments of king penguins (Aptenodytes patagonicus), the size of

  2. Growth, chemical components and ensiling characteristics of king ...

    African Journals Online (AJOL)

    user

    2012-08-09

    Aug 9, 2012 ... Wilting had different effects on the 1st cutting and 3rd cutting silages in pH value and NH3-N content, ... On February 16, 2008, king grass was planted with seed stem on ... Home Electrical Appliance Company Limited, Hongkong, China). ... The plant height and the yield from the first cutting to fourth cutting.

  3. Fish for peasants and kings - a Danish perspective

    DEFF Research Database (Denmark)

    Kristiansen, Mette Svart

    2011-01-01

    Fish played an important role in medieval Europe. It formed the basis of a food culture influenced by Catholicism and was a central commodity in the national and international network of trade. Fish of all sorts held a prominent position on the dining tables of peasants as well as kings. Househol...

  4. Anogeissus sericea var. nummalaria King ex Duthie (Combretaceae ...

    Indian Academy of Sciences (India)

    Anogeissus sericea var. nummalaria King ex Duthie (Combretaceae) is moderate sized multipurpose hard wood tree of dry deciduous forests with drooping branches and yellow to brownish-yellow flowers. it is endemic to Rajasthan and is considered to be a threatened tree of the region due to over exploitation for timber ...

  5. A Novel Initiation Mechanism of Death in Streptococcus pneumoniae Induced by the Human Milk Protein-Lipid Complex HAMLET and Activated during Physiological Death*

    Science.gov (United States)

    Clementi, Emily A.; Marks, Laura R.; Duffey, Michael E.; Hakansson, Anders P.

    2012-01-01

    To cause colonization or infection, most bacteria grow in biofilms where differentiation and death of subpopulations is critical for optimal survival of the whole population. However, little is known about initiation of bacterial death under physiological conditions. Membrane depolarization has been suggested, but never shown to be involved, due to the difficulty of performing such studies in bacteria and the paucity of information that exists regarding ion transport mechanisms in prokaryotes. In this study, we performed the first extensive investigation of ion transport and membrane depolarization in a bacterial system. We found that HAMLET, a human milk protein-lipid complex, kills Streptococcus pneumoniae (the pneumococcus) in a manner that shares features with activation of physiological death from starvation. Addition of HAMLET to pneumococci dissipated membrane polarity, but depolarization per se was not enough to trigger death. Rather, both HAMLET- and starvation-induced death of pneumococci specifically required a sodium-dependent calcium influx, as shown using calcium and sodium transport inhibitors. This mechanism was verified under low sodium conditions, and in the presence of ionomycin or monensin, which enhanced pneumococcal sensitivity to HAMLET- and starvation-induced death. Pneumococcal death was also inhibited by kinase inhibitors, and indicated the involvement of Ser/Thr kinases in these processes. The importance of this activation mechanism was made evident, as dysregulation and manipulation of physiological death was detrimental to biofilm formation, a hallmark of bacterial colonization. Overall, our findings provide novel information on the role of ion transport during bacterial death, with the potential to uncover future antimicrobial targets. PMID:22700972

  6. A novel initiation mechanism of death in Streptococcus pneumoniae induced by the human milk protein-lipid complex HAMLET and activated during physiological death.

    Science.gov (United States)

    Clementi, Emily A; Marks, Laura R; Duffey, Michael E; Hakansson, Anders P

    2012-08-03

    To cause colonization or infection, most bacteria grow in biofilms where differentiation and death of subpopulations is critical for optimal survival of the whole population. However, little is known about initiation of bacterial death under physiological conditions. Membrane depolarization has been suggested, but never shown to be involved, due to the difficulty of performing such studies in bacteria and the paucity of information that exists regarding ion transport mechanisms in prokaryotes. In this study, we performed the first extensive investigation of ion transport and membrane depolarization in a bacterial system. We found that HAMLET, a human milk protein-lipid complex, kills Streptococcus pneumoniae (the pneumococcus) in a manner that shares features with activation of physiological death from starvation. Addition of HAMLET to pneumococci dissipated membrane polarity, but depolarization per se was not enough to trigger death. Rather, both HAMLET- and starvation-induced death of pneumococci specifically required a sodium-dependent calcium influx, as shown using calcium and sodium transport inhibitors. This mechanism was verified under low sodium conditions, and in the presence of ionomycin or monensin, which enhanced pneumococcal sensitivity to HAMLET- and starvation-induced death. Pneumococcal death was also inhibited by kinase inhibitors, and indicated the involvement of Ser/Thr kinases in these processes. The importance of this activation mechanism was made evident, as dysregulation and manipulation of physiological death was detrimental to biofilm formation, a hallmark of bacterial colonization. Overall, our findings provide novel information on the role of ion transport during bacterial death, with the potential to uncover future antimicrobial targets.

  7. Questioning the ‘of’ in Performance-as-translation: Multimedia as a Subtext in the 2003 Pécs Performance ‘of’ Hamlet

    Directory of Open Access Journals (Sweden)

    Minier Márta

    2017-12-01

    Full Text Available This article explores a theatre performance (National Theatre Pécs, 2003, dir. Iván Hargitai working with a 1999 Hungarian translation of Hamlet by educator, scholar, translator and poet Ádám Nádasdy as a structural transformation (Fischer-Lichte 1992 of the dramatic text for the stage. The performance is perceived as an intersemiotic translation but not as one emerging from a source-to-target one-way route. The study focuses on certain substructures such as the set design and the multimedial nature of the performance (as defined by Giesekam 2007, and by highlighting intertextual and hypertextual ways of accessing this performance-as-translation it questions the ‘of’ in the ‘performance of Hamlet (or insert other dramatic title’ phrase. This experimentation with the terminology around performance-as-translation also facilitates the unveiling of a layer of the complex Hungarian Hamlet palimpsest, which, as a multi-layered cultural phenomenon, consists of much more than literary texts: its fabric includes theatre performance and other creative works.

  8. Manuel Tamayo y Baus’s Un Drama Nuevo (1867 and the Reception of Hamlet in 19th-Century Spain

    Directory of Open Access Journals (Sweden)

    Rocío G. Sumillera

    2013-05-01

    Full Text Available The present article discusses how Tamayo y Baus appropriates and refashions in Un drama nuevo (1867 the figures of Shakespeare and Yorick, as well as different elements of a number of tragedies by Shakespeare (Hamlet, Romeo and Juliet, Othello, in order to render homage to Shakespearean drama by means of a play that, even if set at the beginning of 17th-century England, particularly addresses the tastes and concerns of 19th-century Spanish audiences. Additionally, this article considers the extent to which the contemporary audience of Tamayo y Baus was acquainted with Shakespeare and Hamlet, taking into account both the translations into Spanish of the play and its performances in Spain up until 1867. The purpose of such an analysis is to speculate on the reception and interpretation of Un drama nuevo at the time of its release, and on the role it had in raising or renewing interest in Hamlet within the Spanish-speaking world.

  9. Shakespeare Starts a New Century Travel in China: A Comparative Analysis of the Two New Chinese Re-Translations of Hamlet

    Directory of Open Access Journals (Sweden)

    Xiaonong Wang

    2013-04-01

    Full Text Available The two new 21st-century Chinese re-translations of Shakespeare’s Hamlet, one by Hongyin Wang and the other by Guobin Huang, represent continued efforts by Chinese scholars in studying and translating Shakespeare. Compared with those previous translations, these two have realized fresh achievements in such aspects as use of language with characteristics of the times, employment of new para-textual elements, visual arrangement of verse lines, and new treatment of those literary devices in the original work which usually constitute a major challenge to translators of them. And based on the latest academic research achievements with regard to Hamlet, either of them incorporates its translator’s own research findings. The two translations also show some different features. Their main differences lie in that Wang, who translates mainly for the reader, is more concerned with the overall artistic effect by giving full play to the literary and expressive force of Chinese in characterization and uses naturally used Chinese language in characterization. Also, he lifts his translation in a philosophical connotation and a literary conception. Huang’s version, far more annotated, is rendered for the stage and pays much attention to rhythm-rhyming scheme and image correspondence by concise and accurate Chinese, blending elegant and vulgar features according to the characters’ identity. The two translators have made new contribution to the international Shakespeare studies in general and Hamlet studies in particular.

  10. Moessbauer Study of Sedimentary Rocks from King George Island, Antarctica

    International Nuclear Information System (INIS)

    Kuzmann, E.; Souza, P. A. de; Schuch, L. A.; Oliveira, A. C. de; Garg, R.; Garg, V. K.

    2002-01-01

    The separation of continents at the periphery of Antarctica occurred about 180 ma ago due to volcanic activity. Geological faults can be very important in the study of geological occurrences. Such geological faults occur across the Admiralty Bay, King George Island, and have been studied in detail previously. Controversial statements were given in earlier works, based on conventional geological investigations, as to whether altered 'Jurassic' and unaltered Tertiary rocks were separated by a major fault which goes across the Admiralty Bay, or whether there is no difference in the alteration of the rocks located at either side of the fault. The aim of our work is to investigate rock samples from the Admiralty Bay of King George Island, Antarctica, from different locations on both sides of the geological fault. For these investigations 57 Fe Moessbauer spectroscopy and X-ray diffractometry were used. We have found that the phase composition, and the iron distribution among the crystallographic sites of iron-bearing minerals, are characteristic of the location of the rock samples from the Admiralty Bay of King George Island. There is a much higher amount of iron oxides in the rocks from the south part of the geological fault than in the north part. The differences in the mineral composition and iron distribution showed that the rocks in the southern part of the geological fault of King George Island are significantly altered compared to the rocks in the northern part. Our present results support and complement well the results obtained earlier on soils from King George Island.

  11. Fat King Penguins Are Less Steady on Their Feet.

    Directory of Open Access Journals (Sweden)

    Astrid S T Willener

    Full Text Available Returning to the shore after a feeding sojourn at sea, king penguins often undertake a relatively long terrestrial journey to the breeding colony carrying a heavy, mostly frontal, accumulation of fat along with food in the stomach for chick-provisioning. There they must survive a fasting period of up to a month in duration, during which their complete reliance on endogenous energy stores results in a dramatic loss in body mass. Our aim was to determine if the king penguin's walking gait changes with variations in body mass. We investigated this by walking king penguins on a treadmill while instrumented with an acceleration data logger. The stride frequency, dynamic body acceleration (DBA and posture of fat (pre-fasting; 13.2 kg and slim (post fasting; 11 kg king penguins were assessed while they walked at the same speed (1.4 km/h on a treadmill. Paired statistical tests indicated no evidence for a difference in dynamic body acceleration or stride frequency between the two body masses however there was substantially less variability in both leaning angle and the leaning amplitude of the body when the birds were slimmer. Furthermore, there was some evidence that the slimmer birds exhibited a decrease in waddling amplitude. We suggest the increase in variability of both leaning angle and amplitude, as well as a possibly greater variability in the waddling amplitude, is likely to result from the frontal fat accumulation when the birds are heavier, which may move the centre of mass anteriorly, resulting in a less stable upright posture. This study is the first to use accelerometry to better understand the gait of a species within a specific ecological context: the considerable body mass change exhibited by king penguins.

  12. Fat King Penguins Are Less Steady on Their Feet.

    Science.gov (United States)

    Willener, Astrid S T; Handrich, Yves; Halsey, Lewis G; Strike, Siobhán

    2016-01-01

    Returning to the shore after a feeding sojourn at sea, king penguins often undertake a relatively long terrestrial journey to the breeding colony carrying a heavy, mostly frontal, accumulation of fat along with food in the stomach for chick-provisioning. There they must survive a fasting period of up to a month in duration, during which their complete reliance on endogenous energy stores results in a dramatic loss in body mass. Our aim was to determine if the king penguin's walking gait changes with variations in body mass. We investigated this by walking king penguins on a treadmill while instrumented with an acceleration data logger. The stride frequency, dynamic body acceleration (DBA) and posture of fat (pre-fasting; 13.2 kg) and slim (post fasting; 11 kg) king penguins were assessed while they walked at the same speed (1.4 km/h) on a treadmill. Paired statistical tests indicated no evidence for a difference in dynamic body acceleration or stride frequency between the two body masses however there was substantially less variability in both leaning angle and the leaning amplitude of the body when the birds were slimmer. Furthermore, there was some evidence that the slimmer birds exhibited a decrease in waddling amplitude. We suggest the increase in variability of both leaning angle and amplitude, as well as a possibly greater variability in the waddling amplitude, is likely to result from the frontal fat accumulation when the birds are heavier, which may move the centre of mass anteriorly, resulting in a less stable upright posture. This study is the first to use accelerometry to better understand the gait of a species within a specific ecological context: the considerable body mass change exhibited by king penguins.

  13. AHP 47: THE GREEDY KING AND TRICKY MAN

    Directory of Open Access Journals (Sweden)

    Lcags so lhun 'grub ལྕགས་སོ་ལྷུན་འགྲུབ། (Klu sgrub ཀླུ་སྒྲུབ།

    2017-04-01

    Full Text Available Rgya mo skyid (b. 1992 of Mdo ba Town, Reb gong (Thun rin, Tongren County, Rma lho (Huangnan Tibetan Autonomous Prefecture, Mtsho sngon (Qinghai Province, China told me this story in an apartment in Xi'an City, Shaanxi Province on 21 August, 2016. She said, "When I was about five years old, my grandfather (Kun bzang, b. 1939 told me many stories such as this before we went to bed every night. I forgot many stories, but this story is still very clear." There was once a greedy local king who collected taxes monthly. There was also a very poor man known as Tricky Tsag thul. The local king came to Tricky's home to punish him for not paying his taxes for several months. ...

  14. Thermal strategies of king penguins during prolonged fasting in water.

    Science.gov (United States)

    Lewden, Agnès; Enstipp, Manfred R; Bonnet, Batshéva; Bost, Caroline; Georges, Jean-Yves; Handrich, Yves

    2017-12-15

    Most animals experience periods of unfavourable conditions, challenging their daily energy balance. During breeding, king penguins fast voluntarily for up to 1.5 months in the colony, after which they replenish their energy stores at sea. However, at sea, birds might encounter periods of low foraging profitability, forcing them to draw from previously stored energy (e.g. subcutaneous fat). Accessing peripheral fat stores requires perfusion, increasing heat loss and thermoregulatory costs. Hence, how these birds balance the conflicting demands of nutritional needs and thermoregulation is unclear. We investigated the physiological responses of king penguins to fasting in cold water by: (1) monitoring tissue temperatures, as a proxy of tissue perfusion, at four distinct sites (deep and peripheral); and (2) recording their oxygen consumption rate while birds floated inside a water tank. Despite frequent oscillations, temperatures of all tissues often reached near-normothermic levels, indicating that birds maintained perfusion to peripheral tissues throughout their fasting period in water. The oxygen consumption rate of birds increased with fasting duration in water, while it was also higher when the flank tissue was warmer, indicating greater perfusion. Hence, fasting king penguins in water maintained peripheral perfusion, despite the associated greater heat loss and, therefore, thermoregulatory costs, probably to access subcutaneous fat stores. Hence, the observed normothermia in peripheral tissues of king penguins at sea, upon completion of a foraging bout, is likely explained by their nutritional needs: depositing free fatty acids (FFA) in subcutaneous tissues after profitable foraging or mobilizing FFA to fuel metabolism when foraging success was insufficient. © 2017. Published by The Company of Biologists Ltd.

  15. Accumulation factors of mercury by King Bolete Boletus edulis

    Science.gov (United States)

    Falandysz, J.; Frankowska, A.

    2003-05-01

    To understand pollution picture with mercury and to examine suitability of King Bolete Boletits edulis Bull.: Fr. as possible bioindicator the total mercurv concentrations were determined both in the fruiting bodies and underlying soil substrate collected from various regions of Poland. There were quite large spatial variations of mercury concentration and some seasonal also were noted. Mercury content of the caps exceeded that of stalks (p<0.05), Nvhile Hg BCF values varied between 9 and 40, and 4 and 40, respectively.

  16. Pairing Behavior of the Monogamous King Quail, Coturnix chinensis.

    Directory of Open Access Journals (Sweden)

    Elizabeth Adkins-Regan

    Full Text Available Animals with socially monogamous mating systems are valuable for discovering proximate mechanisms of prosocial behavior and close social relationships. Especially powerful are comparisons between related species that differ in monogamous tendency. Birds are the most socially monogamous vertebrates. Thus far most research on mechanisms of pairing has used zebra finches, which do not have a relative with a different mating system, however. The goal of the experiments reported here was to develop a new comparative avian system by studying the pairing behavior of a reportedly strongly monogamous quail, the king quail (Coturnix chinensis, a species in the same clade as the less monogamous Japanese quail (Coturnix japonica, the subject of much prior research. In Experiment 1 male-female pairs of king quail housed together were initially avoidant or aggressive but most rapidly progressed to allopreening and huddling. A separation-reunion paradigm reliably elicited both of these behaviors in males that had cohabited for one week. In Experiment 2 the allopreening and huddling behavior of males in cohabiting pairs was highly selective, and a majority of the males were aggressive toward a familiar female that was not the cohabitation partner. In Experiment 3 males were separated from their female cohabitation partners for 9-10 weeks and then given two-choice tests. All but one male spent more time near an unfamiliar female, which may have reflected aggression and shows recognition of and memory for the past pairing experience. Thus king quail show robust, selective and easy to measure pairing behavior that can be reliably elicited with simple separation-reunion testing procedures. Copulation is rarely seen during tests. The behavior of king quail is a striking contrast to that of Japanese quail, providing a new comparative system for discovering mechanisms of behavior related to close social relationships and monogamy.

  17. Pairing Behavior of the Monogamous King Quail, Coturnix chinensis.

    Science.gov (United States)

    Adkins-Regan, Elizabeth

    2016-01-01

    Animals with socially monogamous mating systems are valuable for discovering proximate mechanisms of prosocial behavior and close social relationships. Especially powerful are comparisons between related species that differ in monogamous tendency. Birds are the most socially monogamous vertebrates. Thus far most research on mechanisms of pairing has used zebra finches, which do not have a relative with a different mating system, however. The goal of the experiments reported here was to develop a new comparative avian system by studying the pairing behavior of a reportedly strongly monogamous quail, the king quail (Coturnix chinensis), a species in the same clade as the less monogamous Japanese quail (Coturnix japonica), the subject of much prior research. In Experiment 1 male-female pairs of king quail housed together were initially avoidant or aggressive but most rapidly progressed to allopreening and huddling. A separation-reunion paradigm reliably elicited both of these behaviors in males that had cohabited for one week. In Experiment 2 the allopreening and huddling behavior of males in cohabiting pairs was highly selective, and a majority of the males were aggressive toward a familiar female that was not the cohabitation partner. In Experiment 3 males were separated from their female cohabitation partners for 9-10 weeks and then given two-choice tests. All but one male spent more time near an unfamiliar female, which may have reflected aggression and shows recognition of and memory for the past pairing experience. Thus king quail show robust, selective and easy to measure pairing behavior that can be reliably elicited with simple separation-reunion testing procedures. Copulation is rarely seen during tests. The behavior of king quail is a striking contrast to that of Japanese quail, providing a new comparative system for discovering mechanisms of behavior related to close social relationships and monogamy.

  18. The anatomy of the king crab Hapalogaster mertensii Brandt, 1850 (Anomura: Paguroidea: Hapalogastridae): new insights into the evolutionary transformation of hermit crabs into king crabs

    NARCIS (Netherlands)

    Keiler, J.; Richter, S.; Wirkner, C.S.

    2015-01-01

    The emergence of king crabs from a hermit crab-like ancestor is one of the most curious events in decapod evolution. King crabs comprise two taxa, Lithodidae and Hapalogastridae, and while lithodids have formed the focus of various anatomical studies, the internal anatomy of hapalogastrids has never

  19. Toward Inclusive Understandings of Marriage in an Early Childhood Classroom: Negotiating (Un)readiness, Community, and Vulnerability through a Critical Reading of "King and King"

    Science.gov (United States)

    Bentley, Dana Frantz; Souto-Manning, Mariana

    2016-01-01

    This collaborative classroom research study examines the ways in which preschoolers made sense of same-sex marriage through a critical reading of the book "King and King" by De Haan and Nijland. Acknowledging the importance of community in doing critical and political work, this article details the ways in which a preschool teacher and a…

  20. Ultraviolet reflecting photonic microstructures in the King Penguin beak.

    Science.gov (United States)

    Dresp, Birgitta; Jouventin, Pierre; Langley, Keith

    2005-09-22

    King and emperor penguins (Aptenodytes patagonicus and Aptenodytes forsteri) are the only species of marine birds so far known to reflect ultraviolet (UV) light from their beaks. Unlike humans, most birds perceive UV light and several species communicate using the near UV spectrum. Indeed, UV reflectance in addition to the colour of songbird feathers has been recognized as an important signal when choosing a mate. The king penguin is endowed with several highly coloured ornaments, notably its beak horn and breast and auricular plumage, but only its beak reflects UV, a property considered to influence its sexual attraction. Because no avian UV-reflecting pigments have yet been identified, the origin of such reflections is probably structural. In an attempt to identify the structures that give rise to UV reflectance, we combined reflectance spectrophotometry and morphological analysis by both light and electron microscopy, after experimental removal of surface layers of the beak horn. Here, we characterize for the first time a multilayer reflector photonic microstructure that produces the UV reflections in the king penguin beak.

  1. Ontogeny of thermoregulatory mechanisms in king penguin chicks (Aptenodytes patagonicus).

    Science.gov (United States)

    Duchamp, Claude; Rouanet, Jean Louis; Barré, Hervé

    2002-04-01

    The rapid maturation of thermoregulatory mechanisms may be of critical importance for optimising chick growth and survival and parental energy investment under harsh climatic conditions. The ontogeny of thermoregulatory mechanisms was studied in growing king penguin chicks from hatching to the full emancipation observed at 1 month of age in the sub-Antarctic area (Crozet Archipelago). Newly hatched chicks showed small, but significant regulatory thermogenesis (21% rise in heat production assessed by indirect calorimetry), but rapidly became hypothermic. Within a few days, both resting (+32%) and peak (+52%) metabolic rates increased. The first week of life was characterised by a two-fold rise in thermogenic capacity in the cold, while thermal insulation was not improved. During the second and third weeks of age, thermal insulation markedly rose (two-fold drop in thermal conductance) in relation to down growth, while resting heat production was slightly reduced (-13%). Shivering (assessed by electromyography) was visible right after hatching, although its efficiency was limited. Thermogenic efficiency of shivering increased five-fold with age during the first weeks of life, but there was no sign of non-shivering thermogenesis. We conclude that thermal emancipation of king penguin chicks may be primarily determined by improvement of thermal insulation after thermogenic processes have become sufficiently matured. Both insulative and metabolic adaptations are required for the rapid ontogeny of thermoregulation and thermal emancipation in growing king penguin chicks.

  2. Pessoa’s myth of the King Sebastian reinterpreted

    Directory of Open Access Journals (Sweden)

    Monika Świda

    2013-01-01

    Full Text Available The present paper depicts alterations undergone by the sleeping king motif (sebastianism in the writings of Fernando Pessoa. The data to conduct the study were collected in thematic anthologies and several unpublished pieces. The myth of the King Sebastian was given a congregational dimension by Pessoa, thus conveying his cultural and identity project subsumed under the metaphor of the spiritual empire. Pessoa introduces some readjustments in the way the historical king is to be conceived of. In his theory, Sebastian becomes the figure of the individual effort on the way towards the national renewal. The messianic character of D. Sebastião is defeated in this theory despite having been associated with the figures of either Jesus or the Antichrist. The messiah of the Portuguese foundation myth is replaced with the idea of great man and the task to be carried out in this field, included the metaphor of the Fifth Empire, gains a cultural character. That is why Pessoa’s theories must no longer be interpreted in messianic terms. The Pessoa’s transformations of the sebastianism analyzed in this article are the starting point for the new national narration in the poetic cycle of "Mensagem".

  3. HIV intertest interval among MSM in King County, Washington.

    Science.gov (United States)

    Katz, David A; Dombrowski, Julia C; Swanson, Fred; Buskin, Susan E; Golden, Matthew R; Stekler, Joanne D

    2013-02-01

    The authors examined temporal trends and correlates of HIV testing frequency among men who have sex with men (MSM) in King County, Washington. The authors evaluated data from MSM testing for HIV at the Public Health-Seattle & King County (PHSKC) STD Clinic and Gay City Health Project (GCHP) and testing history data from MSM in PHSKC HIV surveillance. The intertest interval (ITI) was defined as the number of days between the last negative HIV test and the current testing visit or first positive test. Correlates of the log(10)-transformed ITI were determined using generalised estimating equations linear regression. Between 2003 and 2010, the median ITI among MSM seeking HIV testing at the STD Clinic and GCHP were 215 (IQR: 124-409) and 257 (IQR: 148-503) days, respectively. In multivariate analyses, younger age, having only male partners and reporting ≥10 male sex partners in the last year were associated with shorter ITIs at both testing sites (pGCHP attendees, having a regular healthcare provider, seeking a test as part of a regular schedule and inhaled nitrite use in the last year were also associated with shorter ITIs (pGCHP (median 359 vs 255 days, p=0.02). Although MSM in King County appear to be testing at frequent intervals, further efforts are needed to reduce the time that HIV-infected persons are unaware of their status.

  4. When the King Becomes your Personal Enemy: W. T. Stead, King Leopold II, and the Congo Free State

    Directory of Open Access Journals (Sweden)

    Marysa Demoor

    2013-04-01

    mso-fareast-language:JA;} This paper will highlight an unknown but important episode in the life of the journalist W. T. Stead, which, intriguingly, remained unmentioned in Belgian, British, and colonial historiography. It concerns a face-to-face meeting between Stead and Leopold II, King of the Belgians, which certainly did not leave Stead the ‘friend of all Kings’, as the posthumous article published by the 'Daily Mirror' contended. Based on Stead’s own Character Sketches in the 'Review of Reviews', the paper will show how Stead’s perceptions of the scandalous government of the Congo Free State result to a large extent from his own meeting (probably towards the end of 1884 with King Leopold II, and the King’s refusal to cooperate with Britain in an improvised rescue of General Gordon in Sudan.

  5. Three Kings and the Bright Star of Fame

    Directory of Open Access Journals (Sweden)

    Emalyn J. Bullis

    2013-12-01

    Full Text Available Many phenomena in music history as well as in American history have helped develop and shape the types of music listened to today, but none have been so fresh as looking back to twentieth-century popular music and the several key individuals that “ruled” in this area. These “rulers” were hailed as “kings” firstly as a media ploy, but the American public did nothing but encourage the titles. This is somewhat confusing considering American’s pride in their democratic political system but history shows that in several key American cultural changes the “Kings” crowned in the music sphere are representative of these changes. While not difficult to determine who these individuals are, as most of them were hailed and recognized as “Kings” to their respective audiences. Benny Goodman, the King of Swing, in the 1920’s and 30’s helped usher in and popularize the Swing movement. Elvis Presley, the King of Rock and Roll, capitalized (intentionally or not on the move towards combining African-American sounds such as blues and jazz with folk, gospel, and soul, thus creating a whole new and extremely popular sound. Michael Jackson, the King of Pop, was practically born into fame with his involvement with the ‘Jackson 5,’ but that did not stop him from rising up the ladder of fame in his solo career to change the face of pop music forever. There were also many artists that surrounded these “kings,” a court, if you will, that allowed their new styles to proliferate throughout American culture, and sometimes even surpassed them musically. However, as icons, these men stand on their own for their achievements in music and their ability to change and adapt to the culture around them. By looking at the three Kings of American pop culture’s past, it is possible to see the direction of America’s culture in general from the 1920’s on and perhaps see the trajectory of music of the USA today

  6. No need to be HAMLET or BAMLET to interact with histones: binding of monomeric alpha-lactalbumin to histones and basic poly-amino acids.

    Science.gov (United States)

    Permyakov, Serge E; Pershikova, Irina V; Khokhlova, Tatyana I; Uversky, Vladimir N; Permyakov, Eugene A

    2004-05-18

    The ability of a specific complex of human alpha-lactalbumin with oleic acid (HAMLET) to induce cell death with selectivity for tumor and undifferentiated cells was shown recently to be mediated by interaction of HAMLET with histone proteins irreversibly disrupting chromatin structure [Duringer, C., et al. (2003) J. Biol. Chem. 278, 42131-42135]. Here we show that monomeric alpha-lactalbumin (alpha-LA) in the absence of fatty acids is also able to bind efficiently to the primary target of HAMLET, histone HIII, regardless of Ca(2+) content. Thus, the modification of alpha-LA by oleic acid is not required for binding to histones. We suggest that interaction of negatively charged alpha-LA with the basic histone stabilizes apo-alpha-LA and destabilizes the Ca(2+)-bound protein due to compensation for excess negative charge of alpha-LA's Ca(2+)-binding loop by positively charged residues of the histone. Spectrofluorimetric curves of titration of alpha-LA by histone H3 were well approximated by a scheme of cooperative binding of four alpha-LA molecules per molecule of histone, with an equilibrium dissociation constant of 1.0 microM. Such a stoichiometry of binding implies that the binding process is not site-specific with respect to histone and likely is driven by just electrostatic interactions. Co-incubation of positively charged poly-amino acids (poly-Lys and poly-Arg) with alpha-LA resulted in effects which were similar to those caused by histone HIII, confirming the electrostatic nature of the alpha-LA-histone interaction. In all cases that were studied, the binding was accompanied by aggregation. The data indicate that alpha-lactalbumin can be used as a basis for the design of antitumor agents, acting through disorganization of chromatin structure due to interaction between alpha-LA and histone proteins.

  7. Analysis of Decadal-Scale Shoreline Change along the Hamlet of Paulatuk (Canadian Arctic), using Landsat Satellite Imagery and GIS techniques from 1984 to 2014.

    Science.gov (United States)

    Sankar, R. D.; Murray, M. S.; Wells, P.

    2016-12-01

    Increased accuracy in estimating coastal change along localized segments of the Canadian Arctic coast is essential, in order to identify plausible adaptation initiatives to deal with the effects of climate change. This paper quantifies rates of shoreline movement along an 11 km segment of the Hamlet of Paulatuk (Northwest Territories, Canada), using an innovative modelling technique - Analyzing Moving Boundaries Using R (AMBUR). Approximately two dozen shorelines, obtained from high-resolution Landsat satellite imagery were analyzed. Shorelines were extracted using the band ratio method and compiled in ArcMapTM to determine decadal trends of coastal change. The unique geometry of Paulatuk facilitated an independent analysis of the western and eastern sections of the study area. Long-term (1984-2014) and short-term (1984-2003) erosion and accretion rates were calculated using the Linear Regression and End Point Rate methods respectively. Results reveal an elevated rate of erosion for the western section of the hamlet over the long-term (-1.1 m/yr), compared to the eastern portion (-0.92 m/yr). The study indicates a significant alongshore increase in the rates of erosion on both portions of the study area, over the short-term period 1984 to 2003. Mean annual erosion rates increased over the short-term along the western segment (-1.4 m/yr), while the eastern shoreline retreated at a rate of -1.3 m/yr over the same period. The analysis indicates that an amalgamation of factors may be responsible for the patterns of land loss experienced along Paulatuk. These include increased sea-surface temperature coupled with dwindling arctic ice and elevated storm hydrodynamics. The analysis further reveals that the coastline along the eastern portion of the hamlet, where the majority of the population reside, is vulnerable to a high rate of shoreline erosion.

  8. King penguin population threatened by Southern Ocean warming.

    Science.gov (United States)

    Le Bohec, Céline; Durant, Joël M; Gauthier-Clerc, Michel; Stenseth, Nils C; Park, Young-Hyang; Pradel, Roger; Grémillet, David; Gendner, Jean-Paul; Le Maho, Yvon

    2008-02-19

    Seabirds are sensitive indicators of changes in marine ecosystems and might integrate and/or amplify the effects of climate forcing on lower levels in food chains. Current knowledge on the impact of climate changes on penguins is primarily based on Antarctic birds identified by using flipper bands. Although flipper bands have helped to answer many questions about penguin biology, they were shown in some penguin species to have a detrimental effect. Here, we present for a Subantarctic species, king penguin (Aptenodytes patagonicus), reliable results on the effect of climate on survival and breeding based on unbanded birds but instead marked by subcutaneous electronic tags. We show that warm events negatively affect both breeding success and adult survival of this seabird. However, the observed effect is complex because it affects penguins at several spatio/temporal levels. Breeding reveals an immediate response to forcing during warm phases of El Niño Southern Oscillation affecting food availability close to the colony. Conversely, adult survival decreases with a remote sea-surface temperature forcing (i.e., a 2-year lag warming taking place at the northern boundary of pack ice, their winter foraging place). We suggest that this time lag may be explained by the delay between the recruitment and abundance of their prey, adjusted to the particular 1-year breeding cycle of the king penguin. The derived population dynamic model suggests a 9% decline in adult survival for a 0.26 degrees C warming. Our findings suggest that king penguin populations are at heavy extinction risk under the current global warming predictions.

  9. Geochemical interpretation of Kings Mountain, North Carolina, orientation area

    International Nuclear Information System (INIS)

    Price, V.; Ferguson, R.B.

    1977-01-01

    An orientation study has been made of uranium occurrences in the area of Kings Mountain, North Carolina. This is one of the orientation studies of known uranium occurrences that are being conducted in several geologic provinces and under various climatic (weathering) conditions to provide the technical basis for design and interpretation of NURE geochemical reconnaissance programs. The Kings Mountain area was chosen for study primarily because of the reported presence of high-uranium monazite. This 750-mi 2 area is in the deeply weathered southern Appalachian Piedmont and spans portions of the Inner Piedmont, Kings Mountain, and Charlotte geologic belts. Uranium concentration maps for ground and surface water samples clearly outline the outcrop area of the Cherryville Quartz Monzonite with highs up to 10 ppb uranium near the reported uraninite. Several surface water samples appear to be anomalous because of trace industrial contamination. Uranium concentration maps for -100 to +200 mesh stream sediments indicate the area of monazite abundance. Several samples with >100 ppM uranium content appear to be high in uranium-rich resistate minerals. When the uranium content of sediment samples is ratioed to the sum of Hf, Dy, and Th, the anomaly pattern shifts to coincide with uranium highs in ground and surface water samples. False anomalies from concentrations of monazite (Ce,ThPO 4 ), xenotime (Y,DyPO 4 ), and zircon (Zr,HfSiO 4 ) in stream sediment samples can thus be eliminated. Residual anomalies should be related to unusual uranium enrichment of these common minerals or to the presence of an uncommon uranium-rich mineral. Tantalum, beryllium, and tin in stream sediments correspond to high concentrations of uranium in stream and ground water but not to uranium in sediments. In an initial reconnaissance, several media should be sampled, and it is essential to correct uranium in sediments for the sample mineralogy

  10. Outliers and Extremes: Dragon-Kings or Dragon-Fools?

    Science.gov (United States)

    Schertzer, D. J.; Tchiguirinskaia, I.; Lovejoy, S.

    2012-12-01

    Geophysics seems full of monsters like Victor Hugo's Court of Miracles and monstrous extremes have been statistically considered as outliers with respect to more normal events. However, a characteristic magnitude separating abnormal events from normal ones would be at odd with the generic scaling behaviour of nonlinear systems, contrary to "fat tailed" probability distributions and self-organized criticality. More precisely, it can be shown [1] how the apparent monsters could be mere manifestations of a singular measure mishandled as a regular measure. Monstrous fluctuations are the rule, not outliers and they are more frequent than usually thought up to the point that (theoretical) statistical moments can easily be infinite. The empirical estimates of the latter are erratic and diverge with sample size. The corresponding physics is that intense small scale events cannot be smoothed out by upscaling. However, based on a few examples, it has also been argued [2] that one should consider "genuine" outliers of fat tailed distributions so monstrous that they can be called "dragon-kings". We critically analyse these arguments, e.g. finite sample size and statistical estimates of the largest events, multifractal phase transition vs. more classical phase transition. We emphasize the fact that dragon-kings are not needed in order that the largest events become predictable. This is rather reminiscent of the Feast of Fools picturesquely described by Victor Hugo. [1] D. Schertzer, I. Tchiguirinskaia, S. Lovejoy et P. Hubert (2010): No monsters, no miracles: in nonlinear sciences hydrology is not an outlier! Hydrological Sciences Journal, 55 (6) 965 - 979. [2] D. Sornette (2009): Dragon-Kings, Black Swans and the Prediction of Crises. International Journal of Terraspace Science and Engineering 1(3), 1-17.

  11. Sexual development and reproductive pattern of the Mutton hamlet, Alphestes afer (Teleostei: Epinephelidae: a dyandric, hermaphroditic reef fish

    Directory of Open Access Journals (Sweden)

    Simone Marques

    Full Text Available There is little knowledge on the reproduction of the genus Alphestes. The reproduction of the Mutton hamlet, Alphestes afer, sampled in Pernambuco reefs (Brazil was studied based on macroscopic analysis during reproductive period and histological analysis of gonad material from March 2008 to October 2009. This study showed that A. afer is a diandric, protogynous hermaphrodite. Sex change followed protogynous mode in two pathways: primary males formed from immature female individuals or secondary males formed from resting, ripe or spent female individuals. The numerical distribution of gonad classes by size indicated that females from 11-18 cm L T were immature while females from 16-25 cm L T and males from 12-22 cm L T were in various stages of gonadal development. Individuals identified as immature bisexual and transitional (presenting both ovarian and sperm tissue were sized from 16-24 cm L T. Size of first reproduction for females was 18 cm L T and for males was 12 cm L T. Alphestes afer showed multiple spawning, with spawning season period from August to December 2008 and from August to October 2009. The sex-ratio (females: males in 2008 and 2009 was 0.94:1 during the months of spawning season. Males were smaller than females, reaching maximum size of 22 cm compared to 25 cm observed for females. Males showed a high sperm competition rank (3.8, suggesting intense sperm competition. This latter is a possible indication of a shift in the mating group structure from paired to group spawning. The presence of small males added to high sperm competition index, suggest that this species, while retaining the protogynous pattern, has a reproductive strategy similar to gonochorist epinephelids.

  12. Snake bite envenomation: experience at King Abdulaziz Medical City, Riyadh.

    Science.gov (United States)

    Al-Durihim, H; Al-Hussaini, M; Bin Salih, S; Hassan, I; Harakati, M; Al Hajjaj, A

    2010-04-01

    We surveyed the records of 21 of the 28 snakebite victims seen at King Fahad National Guard Hospital in Riyadh over the 20-year period 1986-2005. The most common symptoms were local pain and swelling and the most common signs oedema and tenderness. Neurotoxicity was not noted in any case. Coagulopathy was recorded for 14/21 patients (66.7%) and 5/19 (26.4%) had leukocytosis. All patients were given tetanus toxoid (100%) and 20 (95.2%) received antivenom. Blood products were administered in 2 cases and prophylactic antibiotics in 10 (47.6%). No allergic reaction to antivenom was reported.

  13. Primary secretory otitis media in Cavalier King Charles spaniels.

    Science.gov (United States)

    Cole, Lynette K

    2012-11-01

    Primary secretory otitis media (PSOM) is a disease that has been described in the Cavalier King Charles spaniel (CKCS). A large, bulging pars flaccida identified on otoscopic examination confirms the diagnosis. However, in many CKCS with PSOM the pars flaccida is flat, and radiographic imaging is needed to confirm the diagnosis. Current treatment for PSOM includes performing a myringotomy into the caudal-ventral quadrant of the pars tensa with subsequent flushing of the mucus out of the bulla using a video otoscope. Repeat myringotomies and flushing of the middle ear are necessary to keep the middle ear free of mucus. Copyright © 2012 Elsevier Inc. All rights reserved.

  14. New Light on the Legendary King Nechepsos of Egypt

    DEFF Research Database (Denmark)

    Ryholt, Kim

    2011-01-01

    This paper identifies several indigenous Egyptian attestations of King Nechepsos, previously well known from Classical sources. The name may be understood as ‘Necho the Wise’, and refers to Necho II of the Twenty-sixth Dynasty. His association with astrology may be related to an eclipse near the ...... the beginning of that king’s historical reign. This paper further identifies the sage Petosiris known from Greek texts as the well-attested sage Petesis. The divine instructors of Nechepsos and Petosiris are identified as Imhotep and Amenhotep son of Hapu....

  15. Just how literal is the King James Version?

    OpenAIRE

    Jan (JH) Kroeze; Manie (CM) van den Heever; Bertus (AJ) van Rooy

    2010-01-01

    Many scholars have the perception that the King James Version (KJV) is a literal translation. However, it is not so easy to define the concept of "literal translation". The simplest definition may be to regard it as word-for-word translation. However, when one compares the KJV carefully with the original Hebrew Bible, there are numerous instances where lexical items are changed to adapt the idiom to that of the target language. In this article, a measuring instrument will be proposed and u...

  16. Burger King in Portugal : to lead or to follow?

    OpenAIRE

    Patrone, Sara Saraiva

    2012-01-01

    In 2001, the Burger King (BK) brand, managed by Ibersol group entered the growing fast food Portuguese market. Marginally higher prices along with the fact of having entered the market 10 years after its most direct competitor (McDonald´s), led BK to a sub leader position. Although being recognized as offering superior quality products when compared to McDonald´s, BK´s growth margins in the Portuguese market have been decreasing since 2007. The company´s uncertainty situation, offers the p...

  17. [Understanding King's model on the paradigm of symbolic interactionism].

    Science.gov (United States)

    Araújo, Iliana Maria de Almeida; Oliveira, Marcos Venícios; de Oliveira, Marcos Venícius; Fernandes, Ana Fátima Carvalho

    2005-01-01

    It was aimed to reflect on King's Theory, according to the approach of Symbolic Interaccionism, and theory analyses model of Meleis. To reach the objective, we proceeded the reading of the three models as mentioned before, looking for the consistencies and discrepancies among the concepts and correlating them. The study allowed to conclude that the theories agree when elucidating the man as a being that reacts and search to understand the meaning of things to his/her circuit, drifting and judging their actions and the one of the other ones. It is important the subject of the meanings could be modified and they generate the elaboration of goals in common.

  18. Martin Luther King, Jr., General Hospital and community involvement.

    Science.gov (United States)

    Humphrey, M M

    1973-07-01

    Community involvement is not just one facet of the new Martin Luther King, Jr., General Hospital's existence. It is the mainstream from which all other activities flow. In addition to meeting the conventional needs of a conventional hospital staff with the core collection of texts and journals, this library goes one step further. It acts as a resource for its community health workers, dietitians, and nurses in their various outreach programs. It serves as a stimulus for the high school or community college student who may be curious about a health career. It also finds time to provide reading material for its patients.

  19. Noh Creation of Shakespeare

    Directory of Open Access Journals (Sweden)

    Munakata Kuniyoshi

    2016-12-01

    Full Text Available This article contains select comments and reviews on Noh Hamlet and Noh Othello in English and Noh King Lear in Japanese. The scripts from these performances were arranged based on Shakespeare’s originals and directed on stage and performed in English by Kuniyoshi Munakata from the early 1980s until 2014. Also, the whole text of Munakata’s Noh Macbeth in English (Munakata himself acted as Macbeth and Lady Macbeth in one play is for the first time publicized. The writers of the comments and reviews include notable people such as John Fraser, Michael Barrett, Upton Murakami, Donald Richie, Rick Ansorg, James David Audlin, Jesper Keller, Jean-Claude Saint-Marc, Jean-Claude Baumier, Judy Kendall, Allan Owen, Yoshio ARAI, Yasumasa OKAMOTO, Tatsuhiko TAIRA, Hikaru ENDO, Kazumi YAMAGATA, Hanako ENDO, Yoshiko KAWACHI, Mari Boyd, and Daniel Gallimore.

  20. Shakespearean tragedies dynamics: identifying a generic structure in Shakespeare's four major tragedies

    Science.gov (United States)

    Domínguez-Rué, Emma; Mrotzek, Maximilian

    2012-10-01

    Many interpretations of Shakespearean tragedy have been conducted, mostly following the principles of interpretation in literary study. In our paper, four tragedies by William Shakespeare - Hamlet, King Lear, Othello, and Macbeth - were analysed systemically to find out whether they inhabit a common structure. Using the plot structure as the basis for our analysis, we identified the most important system elements, their connections, and interactive behaviour using causal loop diagrams (CLDs). Our results revealed that all four tragedies basically conform to Senge's archetypal structure 'shifting the burden', adding the action of the heroine or villain and the characters' boundaries of perception. The results suggest that, even though characters and settings vary highly, these tragedies have similar structures and archetypal solutions exist to overcome the problem. Furthermore, we propose that CLDs and systems archetypes are a reasonable hermeneutic tool to analyse not only Shakespearean tragedies but also other literary works.

  1. MOBILE LEARING - possibilities and perspectives

    DEFF Research Database (Denmark)

    Larsen, Lasse Juel

    2009-01-01

    This paper proposes that SMS (Short Message Service) or text-messaging on mobile devices can serve as an extension or possible create another way of learning traditional scholastic content normally associated with the school system. The potential of the SMS is still very much untapped and largely...... unexplored as a pedagogical tool within teaching and learning domains. This paper is inspired by locative arts and ongoing experiments regarding not only SMS based pervasive systems, but also the more complex usage of mobile devices in investigating urban living conditions and experiences both existentially...... and as an exploring mechanism of the cityscape. This paper aims at discussing the potentials and outlining the possibilities for mobile learning in the traditional school setting. The complexity of these issues derives not only from the traditions of the school system, but also from diverging perspectives...

  2. King County Metro Battery Electric Bus Demonstration: Preliminary Project Results

    Energy Technology Data Exchange (ETDEWEB)

    2017-05-22

    The U.S. Federal Transit Administration (FTA) funds a variety of research projects that support the commercialization of zero-emission bus technology. To evaluate projects funded through these programs, FTA has enlisted the help of the National Renewable Energy Laboratory (NREL) to conduct third-party evaluations of the technologies deployed under the FTA programs. NREL works with the selected agencies to evaluate the performance of the zero-emission buses compared to baseline conventional buses in similar service. The evaluation effort will advance the knowledge base of zero-emission technologies in transit bus applications and provide 'lessons learned' to aid other fleets in incrementally introducing next generation zero-emission buses into their operations. This report provides preliminary performance evaluation results from a demonstration of three zero-emission battery electric buses at King County Metro in King County, Washington. NREL developed this preliminary results report to quickly disseminate evaluation results to stakeholders. Detailed evaluation results will be published in future reports.

  3. King penguins can detect two odours associated with conspecifics.

    Science.gov (United States)

    Cunningham, Gregory B; Bonadonna, Francesco

    2015-11-01

    Recent studies on olfaction in penguins have focused on their use of odours while foraging. It has been proposed for some seabirds that an olfactory landscape shaped by odours coming from feeding areas exists. Islands and colonies, however, may also contribute to the olfactory landscape and may act as an orienting map. To test sensitivities to a colony scent we studied whether King penguins (Aptenodytes patagonicus) could detect the smell of sand, feathers or feces by holding presentations beneath their beaks while they naturally slept on the beach. Penguins had a significantly greater response to the feathers and feces presentations than to sand. Although only a first step in exploring a broader role of olfaction in this species, our results raise the possibility of olfaction being used by King penguins in three potential ways: (1) locating the colony from the water or the shore, (2) finding the rendezvous zone within the colony where a chick or partner may be found, or (3) recognizing individuals by scent, as in Humboldt penguins (Spheniscus demersus). © 2015. Published by The Company of Biologists Ltd.

  4. Structural organisation and dynamics in king penguin colonies

    Science.gov (United States)

    Gerum, Richard; Richter, Sebastian; Fabry, Ben; Le Bohec, Céline; Bonadonna, Francesco; Nesterova, Anna; Zitterbart, Daniel P.

    2018-04-01

    During breeding, king penguins do not build nests, however they show strong territorial behaviour and keep a pecking distance to neighbouring penguins. Penguin positions in breeding colonies are highly stable over weeks and appear regularly spaced, but thus far no quantitative analysis of the structural order inside a colony has been performed. In this study, we use the radial distribution function to analyse the spatial coordinates of penguin positions. Coordinates are obtained from aerial images of two colonies that were observed for several years. Our data demonstrate that the structural order in king penguin colonies resembles a 2D liquid of particles with a Lennard-Jones-type interaction potential. We verify this using a molecular dynamics simulation with thermally driven particles, whereby temperature corresponds to penguin movements, the energy well depth ɛ of the attractive potential corresponds to the strength of the colony-forming behaviour, and the repulsive zone corresponds to the pecking radius. We can recapitulate the liquid disorder of the colony, as measured by the radial distribution function, when the particles have a temperature of several (1.4–10) \

  5. Surface Flux Measurements at King Sejong Station in West Antarctica

    Science.gov (United States)

    Choi, T.; Lee, B.; Lee, H.; Shim, J.

    2004-12-01

    The Antarctic Peninsula is important in terms of global warming research due to pronounced increase of air temperature over the last century. The first eddy covariance system was established and turbulent fluxes of heat, water vapor, CO2 and momentum have been measured at King Sejong Station (62 \\deg 13øØS, 58 \\deg 47øØW) located in the northern edge of the Antarctic Peninsula since December in 2002. Our objectives are to better understand the interactions between the Antarctic land surface and the atmosphere and to test the feasibility of the long-term operation of eddy covariance system under extreme weather conditions. Various lichens cover the study area and the dominant species is Usnea fasciata-Himantormia. Based on the analyses on turbulent statistics such as integral turbulence characteristics of vertical velocity (w) and heat (T), stationarity test and investigation of correlation coefficient, they follow the Monin-Obukhov similarity and eddy covariance flux data were reliable. About 50 % of total retrieved sensible heat flux data could be used for further analysis. We will report on seasonal variations of energy and mass fluxes and environmental variables. In addition, factors controlling these fluxes will be presented. Acknowledgement: This study was supported by ¡rEnvironmental Monitoring on Human Impacts at the King Sejong Station, Antarctica¡_ (Project PP04102 of Korea Polar Research Institute) and ¡rEco-technopia 21 project¡_ (Ministry of Environment of Korea).

  6. The Greek charter of the Hungarian King Stephen I

    Directory of Open Access Journals (Sweden)

    Stojkovski Boris

    2016-01-01

    Full Text Available The first Hungarian Christian ruler, King Stephen I (997-1038 issued several charters that have survived to this day. One of them is the charter issued on behalf of the nuns from the Monastery of the Holy Theotokos in Veszprémvölgy. The charter was written in the Greek language, and has been the subject of many studies. The original has not been preserved; what remains is a copy from the time of King Coloman, dated to 1109. The charter has not been published in a critical edition in any language other than Hungarian and even though it has been examined by numerous Hungarian scholars, many questions remain open. The aim of the author is to provide a critical edition and an English translation of the charter, but also to clarify some remaining doubts about the charter and its contents. Furthermore, some comparisons will be made with the Byzantine charters issued at the beginning of the 11th and during the 12th century.

  7. [Neurological evaluation of the leper king Baldwin IV of Jerusalem].

    Science.gov (United States)

    Guerrero-Peral, A L

    In the medieval period, physicians became more aware of leprosy symptoms and differentiated it from other similar diseases. Baldwin, the leper king of Jerusalem (1161-1185), probably contributed to an increasing interest and tolerance to this disease in medieval Christian states. We review historical descriptions of the neurological manifestations he developed. William of Tyre gives us a description of first symptoms experienced by the prince when aged nine. He notices that half of his right arm and hand were partially numb. No skin or nervous lesions are described. By his early twenties, muscle weakness makes him unable to walk. He gets blinded, probably due to keratopathy related to facial nerves involvement. Repeated attacks of fever lead to progressive worsening of his disease. He finally dies in Jerusalem, aged twenty-five, probably due to a septicaemia from infected sores. The earliest sign of Baldwin's disease is anaesthesia. Though skin lesions are not described, it is likely that at this point he had a tuberculoid form of leprosy. As his disease finally takes a lepromatous form, we suspect that it began as a borderline, immunologically unstable form. Leper king Baldwin biography gives us interesting descriptions of neurological clinical features of leprosy. Besides, it helps us to discover twelfth century medicine knowledge about this disease.

  8. The Defence of Moratín’s «Hamlet» in the «Continuación del Semanario de Salamanca»

    Directory of Open Access Journals (Sweden)

    Philip DEACON

    2015-05-01

    Full Text Available In volume 12 of Cuadernos Dieciochistas Professor Pedro Álvarez de Miranda revealed the existence of an issue of the Continuación del Semanario de Salamanca, dated 19 April 1800, which included a Letter in defence of the translation by Leandro Fernández de Moratín of Shakespeare’s tragedy Hamlet.The Letter, signed by a mysterious P. Ozerín-Jáuregui y Z., attacks the Examen of Moratín’s volume published by the Mallorcan man of letters Cristóbal Cladera and sets out a series of objections which in effect defend the quality of the translation and the historical information accompanying it. The present article attempts to place the newly-discovered critical text in its literary and historical contexts, analyzing its arguments and approach, and evaluating its contribution to the on-going debate over the quality of Moratín’s Hamlet. The article includes, by way of appendix, an annotated transcription of the complete Letter as published in the Continuación del Semanario de Salamanca.

  9. AFSC/RACE/SAP/Long: Data from: Habitat, predation, growth, and coexistence: Could interactions between juvenile red and blue king crabs limit blue king crab productivity?

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is from a series of laboratory experiments examining the interactions between red and blue king crabs and habitat. We examined how density and predator...

  10. 1/13 the establishment of kingdoms and the identification of kings ...

    African Journals Online (AJOL)

    Dr Tanya du Plessis

    disputes, but this article will focus on the newly-created positions of kings and queens. 2 .... (2) The person currently holding office as the King of the Zulu nation .... community (tribe) is no better than the colonial-apartheid recognition of tribes.

  11. The King James Bible and the Politics of Religious Education: Secular State and Sacred Scripture

    Science.gov (United States)

    Gearon, Liam

    2013-01-01

    This article provides an outline historical-educational analysis of the King James Bible from its 1611 publication through to its four-hundredth anniversary commemoration in 2011. With particular focus on England, the article traces the educational impact of the King James Bible and charts, in the country of its origin, its progressive decline in…

  12. Fisher research and the Kings River Sustainable Forest Ecosystem Project: current results and future efforts

    Science.gov (United States)

    Brian B. Boroski; Richard T. Golightly; Amie K. Mazzoni; Kimberly A. Sager

    2002-01-01

    The Kings River Sustainable Forest Ecosystems Project was initiated on the Kings River Ranger District of the Sierra National Forest, California, in 1993, with fieldwork beginning in 1994. Knowledge of the ecology of the fisher (Martes pennanti) in the Project area, and in the Sierra Nevada of California in general, is insufficient to develop...

  13. His Majesty King Abdullah II of the Hashemite Kingdom of Jordan.

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    Photo 03: King of Jordan visited some ATLAS installations. From left to right: Maurice Bourquin, President of the CERN Council, Luciano Maiani, Director-General of CERN, King Abdullah II of Jordan, Herwig Schopper, President of the SESAME Council and Peter Jenni, ATLAS spokesman.

  14. The Relationship between Body Image Satisfaction and Bulimia Nervosa among King Saud University Students

    Science.gov (United States)

    Aljomaa, Suliman Saleh

    2018-01-01

    The study aimed at examining the relationship between body image satisfaction and bulimia nervosa among the students of education faculty at king said university students. The author used the tests of bulimia nervosa and body image test. The researcher verified tests reliability. Students from King Saud University randomly selected (No. 337)…

  15. Reading Stephen King: Issues of Censorship, Student Choice, and Popular Literature.

    Science.gov (United States)

    Power, Brenda Miller, Ed.; Wilhelm, Jeffrey D., Ed.; Chandler, Kelly, Ed.

    This collection of essays grew out of the "Reading Stephen King Conference" held at the University of Maine in 1996. Stephen King's books have become a lightning rod for the tensions around issues of including "mass market" popular literature in middle and high school English classes and of who chooses what students read.…

  16. Whatsapp for Educational Purposes for Female Students at College of Education--King Saud University

    Science.gov (United States)

    Aljaad, Nawal Hamad Mohmad

    2017-01-01

    This research aims at finding out the educational usages of "Whatsapp" by the Saudi female students who are involved in the College of Education at King Saud University. To achieve the goal of this study, the researcher uses a simple sample of (122) female students from the Education College of King Saud University, which is chosen…

  17. Connect the Book. Martin's Big Words: The Life of Dr. Martin Luther King, Jr.

    Science.gov (United States)

    Brodie, Carolyn S.

    2005-01-01

    In honor of Martin Luther King, Jr. Day, this month's featured book is "Martin's Big Words: The Life of Dr. Martin Luther King, Jr." The book was written by Doreen Rappaport and illustrated by Bryan Collier (Jump at the Sun, 2001. 40p. ISBN 0786807148). This pictorial biography of the world-renowned civil rights leader has one of the most striking…

  18. 78 FR 39599 - Safety Zone; Independence Day Fireworks, Kings Beach, CA

    Science.gov (United States)

    2013-07-02

    ... Zone; Independence Day Fireworks, Kings Beach, CA AGENCY: Coast Guard, DHS. ACTION: Notice of... Fireworks, Kings Beach, CA in the Captain of the Port, San Francisco area of responsibility during the dates... from the hazards associated with the fireworks display. During the enforcement period, unauthorized...

  19. From Typology to Topography in Clarence King's "Mountaineering in the Sierra Nevada."

    Science.gov (United States)

    Hoekzema, Loren

    The book "Mountaineering in the Sierra Nevada" by Clarence King, a late-ninteenth-century American geologist, writer, art critic, and romantic, is discussed in this paper. In the writing and revision of this book, King was attempting a metamorphosis of landscape description into popular reading as he moved from being a symbolic writer to…

  20. Baking hot. Burger King is testing a restaurant with solar power supply; Unter der Sonne braten. Der Fastfood-Riese Burger King testet ein Restaurantkonzept mit Solaranlage

    Energy Technology Data Exchange (ETDEWEB)

    Kaizl, Mira

    2010-07-15

    At Waghaeusel in the German state of Baden-Wuerttemberg, the local solar provider Wirsol Solar AG constructed a restaurant building for the Burger King GmbH. The building consumes comparably little energy and has a solar roof for photovoltaic power generation. Burger King hopes for good money and a clean image, while Wirsol Solar is hoping for new projects in Europe and in the USA. (orig.)

  1. 76 FR 5326 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; King and Spanish Mackerel Coastal...

    Science.gov (United States)

    2011-01-31

    ... Spanish Mackerel Coastal Migratory Pelagic Fishery Off the Southern Atlantic States; Control Date AGENCY... that it is establishing a new control date to control future access to the king and Spanish mackerel... September 17, 2010, for king and Spanish mackerel. The Council requested a new control date for the king and...

  2. Biological Activities and Phytochemicals of Swietenia macrophylla King

    Directory of Open Access Journals (Sweden)

    Habsah Abdul Kadir

    2013-08-01

    Full Text Available Swietenia macrophylla King (Meliaceae is an endangered and medicinally important plant indigenous to tropical and subtropical regions of the World. S. macrophylla has been widely used in folk medicine to treat various diseases. The review reveals that limonoids and its derivatives are the major constituents of S. macrophylla. There are several data in the literature indicating a great variety of pharmacological activities of S. macrophylla, which exhibits antimicrobial, anti-inflammatory, antioxidant effects, antimutagenic, anticancer, antitumor and antidiabetic activities. Various other activities like anti-nociceptive, hypolipidemic, antidiarrhoeal, anti-infective, antiviral, antimalarial, acaricidal, antifeedant and heavy metal phytoremediation activity have also been reported. In view of the immense medicinal importance of S. macrophylla, this review aimed at compiling all currently available information on its ethnomedicinal uses, phytochemistry and biological activities of S. macrophylla, showing its importance.

  3. Observations of Terrestrial Nightglow (Meinel Bands) at King

    Science.gov (United States)

    Won, Young-In; Cho, Young-Min; Lee, Bang Yong; Kim, Jhoon; Chung, Jong Kyun; Kim, Yong Ha

    1999-12-01

    A Fourier Transform Spectrometer was used to study upper mesospheric thermodynamic by observing the hydroxyl(OH) emission. Rocket-born and satellited-born photometers place the peak emission near 87 μm. The instrument was installed in February 1999 at King Sejong station (62.22 deg S,301.25 deg E), Antarctica and has been in routine operation since then. An intensive operational effort has resulted in a substantial data between April and June, 1999. A harmonic analysis was carried out to examine information on the tidal characteristics. The measured amplitudes of the 12-hour oscillation are in the range of 2.4-3.7 K, which are in resonable agreement with theoretical model outputs. The harmonic analysis also revealed 8-hour oscillation which is not expected from the traditional theoretical studies. In addition, the observed 8-hour oscillations are apparent and sometimes dominate the temperature variation in the upper mesosphere.

  4. INSIGHT AGONISTES: A READING OF SOPHOCLES'S OEDIPUS THE KING.

    Science.gov (United States)

    Mahon, Eugene J

    2015-07-01

    In this reading of Sophocles's Oedipus the King, the author suggests that insight can be thought of as the main protagonist of the tragedy. He personifies this depiction of insight, calling it Insight Agonistes, as if it were the sole conflicted character on the stage, albeit masquerading at times as several other characters, including gods, sphinxes, and oracles. This psychoanalytic reading of the text lends itself to an analogy between psychoanalytic process and Sophocles's tragic hero. The author views insight as always transgressing against, always at war with a conservative, societal, or intrapsychic chorus of structured elements. A clinical vignette is presented to illustrate this view of insight. © 2015 The Psychoanalytic Quarterly, Inc.

  5. THE QUEST FOR KNOWLEDGE IN "THE KING JAMES BIBLE"

    Directory of Open Access Journals (Sweden)

    Ewa Piotrowska-Oberda

    2014-10-01

    Full Text Available The aim of this article is the quest for knowledge in "The King James Bible" (1611 in terms of quantitative and qualitative research methodology with the application of the statistical analysis tool Antconc. The quest for knowledge with the use of corpus research aims at discussing the Biblical concept of knowledge through the origin, the object of knowledge, its implications and its constant development. Knowledge is often seen as of divine nature, reflected in the soul of man. It is based not only on logical, but also on the spiritual and ethical reasoning. The object of knowledge is light, reflecting the divine nature of knowledge which exceeds the intellect to reach a deeper spiritual human reasoning. In "The King James Bible" (1611 the authors of New Testament consider human knowledge to be imperfect and partial. They emphasize the need for a spiritual man aiming at reaching a complete knowledge. This spiritual development is based on the relationship between knowledge and faith, as well as knowledge and love. For the authors of the books of the New Testament there is no dichotomy between both knowledge and faith and knowledge and love, because faith and love depend on knowledge that originates in the word of God and leads to spiritual development. From this perspective, religious knowledge, love and mercy as well as faith developed through the knowledge of the biblical text leads to the knowledge of God, the enlightening source of ultimate knowledge. Thus, in the spiritual development of man not only the knowledge and faith but also emotional intelligence, which expresses itself through love and charity as the safer guide in all controversial issues, are important.

  6. The philosophical premises of the second King Report on corporate governance

    Directory of Open Access Journals (Sweden)

    G.J. Rossouw

    2005-07-01

    Full Text Available This article focuses on the philosophical presuppositions of the second King Report on corporate governance for South Africa (hereafter referred to as the King II Report. Especially in the “Introduction and Background” section of the King II Report it is clear that the Report is premised upon a specific understanding of the present-day corporation and its moral obligations. The purpose of this article is to commit what Charles Taylor called “an act of retrieval” in which the philosophical premises of the King II Report will be unearthed and exposed. It will be argued that the view of the present-day corporation that underlies the King II Report could be related back to a number of debates on the notion of the comtemporary corporation and its moral responsibilities that have been played out since the 1970s. It will be indicated how these debates provide the philosophical foundations for the view of the comtemporary corporation and its moral obligations that is espoused in the King II Report. The claim made in the Report that the African world view and culture influenced the Report’s notion of corporate governance will also be critically reviewed. Finally it will be attempted to evaluate to what extent the recommendations of the King II Report live up to its own philosophical premises.

  7. Distribution and habitat use of king rails in the Illinois and Upper Mississippi River valleys

    Science.gov (United States)

    Darrah, Abigail J.; Krementz, David G.

    2009-01-01

    The migratory population of the king rail (Rallus elegans) has declined dramatically during the past 40 years, emphasizing the need to identify habitat requirements of this species to help guide conservation efforts. To assess distribution and habitat use of king rails along the Illinois and Upper Mississippi valleys, USA, we conducted repeated call-broadcast surveys at 83 locations in 2006 and 114 locations in 2007 distributed among 21 study sites. We detected king rails at 12 survey locations in 2006 and 14 locations in 2007, illustrating the limited distribution of king rails in this region. We found king rails concentrated at Clarence Cannon National Wildlife Refuge, an adjacent private Wetlands Reserve program site, and B. K. Leach Conservation Area, which were located in the Mississippi River floodplain in northeast Missouri. Using Program PRESENCE, we estimated detection probabilities and built models to identify habitat covariates that were important in king rail site occupancy. Habitat covariates included percentage of cover by tall (> 1 m) and short (wetlands that were characterized by high water-vegetation interspersion and little or no cover by woody vegetation. Our results suggest that biologists can improve king rail habitat by implementing management techniques that reduce woody cover and increase vegetation-water interspersion in wetlands.

  8. JEWISH IDEA: FROM KING TEMPLE TO KING STATE YAHUDİ İDEASI: KRAL MABEDİNDEN KRAL DEVLETE

    Directory of Open Access Journals (Sweden)

    Mustafa YİĞİTOĞLU

    2012-06-01

    Full Text Available The study focuses on a process that has become the main problem of Judaism. As the subject, this article is reflectiton the world and the beyond world of the point of view of Judaism. This actually means that the analysis in general terms the history of Jewish thought. Although concentrated in the research issue is not exactly a history of thought. But this article examines the structure of Judaism directly. Firstly in this research discusses King Solomon’s temple which was built as an indicator of Judaism is institutionalized and the idea of Jewish towards to King State. Bu çalışma Yahudiliğin temel sorunu haline gelen bir süreci ele almaktadır. Konu itibari ile Yahudiliğin dünyaya ve dünya ötesine bakış açısını yansıtmaktadır. Bu, aslında Yahudi düşünce tarihinin genel anlamda analizi demektir. Gerçi araştırmanın yoğunlaştığı husus tam anlamıyla bir düşünce tarihi değildir. Ancak alan itibariyle Yahudiliğin doğrudan yapısını inceleyen bir duruma haizdir.Araştırmada ilk olarak Yahudiliğin kurumsallaştığının bir göstergesi olan Kral Süleyman’ın inşa ettirdiği mabed; önemi, konumu ve etkisi gibi hususiyetleriyle tarihsel bir çerçevede ele alınmış, nihayetinde Kral Devlete doğru giden bir Yahudi düşüncesine yer verilmiştir.

  9. Widespread and evolutionary analysis of a MITE family Monkey King in Brassicaceae.

    Science.gov (United States)

    Dai, Shutao; Hou, Jinna; Long, Yan; Wang, Jing; Li, Cong; Xiao, Qinqin; Jiang, Xiaoxue; Zou, Xiaoxiao; Zou, Jun; Meng, Jinling

    2015-06-19

    Miniature inverted repeat transposable elements (MITEs) are important components of eukaryotic genomes, with hundreds of families and many copies, which may play important roles in gene regulation and genome evolution. However, few studies have investigated the molecular mechanisms involved. In our previous study, a Tourist-like MITE, Monkey King, was identified from the promoter region of a flowering time gene, BnFLC.A10, in Brassica napus. Based on this MITE, the characteristics and potential roles on gene regulation of the MITE family were analyzed in Brassicaceae. The characteristics of the Tourist-like MITE family Monkey King in Brassicaceae, including its distribution, copies and insertion sites in the genomes of major Brassicaceae species were analyzed in this study. Monkey King was actively amplified in Brassica after divergence from Arabidopsis, which was indicated by the prompt increase in copy number and by phylogenetic analysis. The genomic variations caused by Monkey King insertions, both intra- and inter-species in Brassica, were traced by PCR amplification. Genomic sequence analysis showed that most complete Monkey King elements are located in gene-rich regions, less than 3kb from genes, in both the B. rapa and A. thaliana genomes. Sixty-seven Brassica expressed sequence tags carrying Monkey King fragments were also identified from the NCBI database. Bisulfite sequencing identified specific DNA methylation of cytosine residues in the Monkey King sequence. A fragment containing putative TATA-box motifs in the MITE sequence could bind with nuclear protein(s) extracted from leaves of B. napus plants. A Monkey King-related microRNA, bna-miR6031, was identified in the microRNA database. In transgenic A. thaliana, when the Monkey King element was inserted upstream of 35S promoter, the promoter activity was weakened. Monkey King, a Brassicaceae Tourist-like MITE family, has amplified relatively recently and has induced intra- and inter-species genomic

  10. Synchronization and an application of a novel fractional order King Cobra chaotic system

    Energy Technology Data Exchange (ETDEWEB)

    Muthukumar, P., E-mail: muthukumardgl@gmail.com; Balasubramaniam, P., E-mail: balugru@gmail.com [Department of Mathematics, Gandhigram Rural Institute‐Deemed University, Gandhigram 624 302, Tamilnadu (India); Ratnavelu, K., E-mail: kuru052001@gmail.com [Faculty of Science, Institute of Mathematical Sciences, University of Malaya, 50603 Kuala Lumpur (Malaysia)

    2014-09-01

    In this paper, we design a new three dimensional King Cobra face shaped fractional order chaotic system. The multi-scale synchronization scheme of two fractional order chaotic systems is described. The necessary conditions for the multi-scale synchronization of two identical fractional order King Cobra chaotic systems are derived through feedback control. A new cryptosystem is proposed for an image encryption and decryption by using synchronized fractional order King Cobra chaotic systems with the supports of multiple cryptographic assumptions. The security of the proposed cryptosystem is analyzed by the well known algebraic attacks. Numerical simulations are given to show the effectiveness of the proposed theoretical results.

  11. Analysing the Concepts of Vengeance and Hono(ur in Shakespeare´s Hamlet and Sumarokov´s Gamlet: A Corpus-based Approach to Literature

    Directory of Open Access Journals (Sweden)

    Irina Keshabyan

    2009-12-01

    Full Text Available The present paper aims at carrying out structural and lexical analysis of two contrasting plays –Shakespeare´s Hamlet and Sumarokov´s Gamlet- in a specific linguistic domain. In this contribution, we will attempt to gain some insight into two essential content words: vengeance and hono(ur, their derivatives and related words, through quantitative analysis of these words and qualitative analysis of their collocates and concordances. Collocational approach will be used to analyse and compare the ways the authors perceive the concepts of vengeance and hono(ur. In general, the findings will indicate important similarities and/or differences between the structures of the plays per acts and both texts´ basic contents in relation to two important topics -vengeance and hono(ur.El presente artículo tiene como objetivo un análisis estructural y léxico de dos obras contrastivas –Hamlet de Shakespeare y Gamlet de Sumarokov- en un dominio lingüístico específico. En esta contribución, intentaremos adentrarse en el estudio de dos sustantivos: venganza y honor, sus derivados y palabras relacionadas- a través de un análisis cuantitativo de las mismas y el análisis cualitativo de sus colocados y concordancias. El método de los colocados será utilizado para analizar y comparar el modo en que los autores perciben los conceptos de venganza y honor. En general, los resultados van a señalar las similitudes y/o diferencias importantes entre las estructuras de las obras por actos y los contenidos básicos de ambos textos en relación con dos temas importantes, tal como, venganza y honor.

  12. Radiological Risk Assessment for King County Wastewater Treatment Division

    Energy Technology Data Exchange (ETDEWEB)

    Strom, Daniel J.

    2005-08-05

    Staff of the King County Wastewater Treatment Division (WTD) have concern about the aftermath of a radiological dispersion event (RDE) leading to the introduction of significant quantities of radioactive material into the combined sanitary and storm sewer system in King County, Washington. Radioactive material could come from the use of a radiological dispersion device (RDD). RDDs include "dirty bombs" that are not nuclear detonations but are explosives designed to spread radioactive material (National Council on Radiation Protection and Measurements (NCRP) 2001). Radioactive material also could come from deliberate introduction or dispersion of radioactive material into the environment, including waterways and water supply systems. This document develops plausible and/or likely scenarios, including the identification of likely radioactive materials and quantities of those radioactive materials to be involved. These include 60Co, 90Sr, 137Cs, 192Ir, 226Ra, plutonium, and 241Am. Two broad categories of scenarios are considered. The first category includes events that may be suspected from the outset, such as an explosion of a "dirty bomb" in downtown Seattle. The explosion would most likely be heard, but the type of explosion (e.g., sewer methane gas or RDD) may not be immediately known. Emergency first responders must be able to quickly detect the radioisotopes previously listed, assess the situation, and deploy a response to contain and mitigate (if possible) detrimental effects resulting from the incident. In such scenarios, advance notice of about an hour or two might be available before any contaminated wastewater reaches a treatment plant. The second category includes events that could go initially undetected by emergency personnel. Examples of such a scenario would be the inadvertent or surreptitious introduction of radioactive material into the sewer system. Intact rogue radioactive sources from industrial radiography devices, well-logging apparatus, or

  13. GPM GROUND VALIDATION DUAL POLARIZED C-BAND DOPPLER RADAR KING CITY GCPEX V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The GPM Ground Validation Dual Polarized C-Band Doppler Radar King City GCPEx dataset has special Range Height Indicator (RHI) and sector scans of several dual...

  14. King Chulalongkorn: biography and his activities in medicine and public health.

    Science.gov (United States)

    Charulukananan, Somrat; Sueblinvong, Tada

    2003-06-01

    King Rama V, or Chulalongkorn, was the fifth monarch of the Chakri Dynasty. He was one of the most beloved of the Thai kings due to his many activities including abolishing slavery without bloodshed and especially his skillful diplomacy which succeeded in steering Siam out of the grips of the colonial powers. His activities also included reform of the administration of the kingdom according to the European model and in bringing Siam into the modern era with such exquisite skills that he is still vividly remembered today. His reign also saw many developments in medicine and public health. The King's role in these areas, however, were clouded by his more visible activities in politics and diplomacy. The result is that the Thai public learned rather little about his role in these areas. This article aims at collecting this and to show the King's very important role in modernizing medicine and public health in Siam.

  15. Responses by king snakes (Lampropeltis getulus) to chemicals from colubrid and crotaline snakes.

    Science.gov (United States)

    Weldon, P J; Schell, F M

    1984-10-01

    Four litters of king snakes (Lampropeltis getulus), a snake-eating species, were tested for responses to chemicals from colubrid and crotaline snakes. King snakes presented with swabs rubbed against the dorsal skin of living snakes and with swabs treated with methylene chloride extracts of shed snake skins tongue-flicked more to swabs from a northern copperhead (Agkistrodon contortrix), a crotaline, than to swabs from some colubrid snakes or to blank swabs. Six out of 10 king snakes in one litter attacked and attempted to ingest swabs treated with snake skin chemicals, implicating these chemicals as feeding stimuli for these ophiophagous snakes. Ingestively naive king snakes presented with plain air and snake odors in an olfactometer tongue-flicked more to snake odors. This study and others suggest that crotaline and colubrid snakes can be distinguished by chemical cues.

  16. AFSC/RACE/SAP/Cummiskey: Red king crab sonic tagging and dive database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This is data from a long-term monitoring project which utilized sonic tags to follow aggregations of red king crab in Womens Bay near Kodiak Alaska. The database...

  17. AFSC/RACE/SAP/Swiney: Red king crab fecundity and embryo and larval quality

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Stock assessment of Alaskan red king crab, Paralithodes camtschaticus (Tilesius, 1815), can be improved by incorporating reproductive output, which requires an...

  18. Micro-gravity studies in archeo-prospecting of the Valley of the Kings, Luxor, Egypt

    Czech Academy of Sciences Publication Activity Database

    Issawy, E. A.; Tealeb, A. A.; Mrlina, Jan; Radwan, A. H.; Hassan, G. S.; Sakr, K. O.

    - (2001), s. 201-212 ISSN 1110-6417 Institutional research plan: CEZ:AV0Z3012916 Keywords : micro-gravity investigations * archaeo-prospecting * Valley of the Kings * Egypt Subject RIV: DE - Earth Magnetism, Geodesy, Geography

  19. The Ride of the Kings in Vlčnov from the Perspective of Contemporary Research

    Czech Academy of Sciences Publication Activity Database

    Stavělová, Daniela

    2015-01-01

    Roč. 25, č. 5 (2015), s. 47-64 ISSN 0862-8351 Institutional support: RVO:68378076 Keywords : Ride of the Kings * field research * methodology * festival * traditional custom * Vlčnov Subject RIV: AC - Archeology, Anthropology, Ethnology

  20. Lichen flora around the Korean Antarctic Scientific Station, King George Island, Antarctic.

    Science.gov (United States)

    Kim, Ji Hee; Ahn, In-Young; Hong, Soon Gyu; Andreev, Mikhail; Lim, Kwang-Mi; Oh, Mi Jin; Koh, Young Jin; Hur, Jae-Seoun

    2006-10-01

    As part of the long-term monitoring projects on Antarctic terrestrial vegetation in relation to global climate change, a lichen floristical survey was conducted around the Korean Antarctic Station (King Sejong Station), which is located on Barton Peninsula, King George Island, in January and February of 2006. Two hundred and twenty-five lichen specimens were collected and sixty-two lichen species in 38 genera were identified by morphological characteristics, chemical constituents, TLC analysis and ITS nucleotide sequence analysis.

  1. Hamlet and economics

    International Nuclear Information System (INIS)

    Shiffer, J.D.

    1994-01-01

    The Department of Energy seems to understand the difference between readiness and realization very well. It has a clear and realistic view of the situation; the DOE believes in getting ready. It takes the view that we live in a unpredictable world. DOE knows that today, after 20 years of commitment to the nation's energy independence, we are more independent on imported oil than we were in 1973

  2. A preliminary appraisal of sediment sources and transport in Kings Bay and vicinity, Georgia and Florida

    Science.gov (United States)

    McConnell, J.B.; Radtke, D.B.; Hale, T.W.; Buell, G.R.

    1983-01-01

    Water-quality, bottom-material, suspended-sediment, and current-velocity data were collected during November 1981 in Kings Bay and vicinity to provide information on the sources and transport of estuarine sediments. Kings Bay and Cumberland Sound , the site of the Poseidon Submarine Base in southeast Georgia, are experiencing high rates of sediment deposition and accumulation, which are causing serious navigational and operational problems. Velocity, bathymetry, turbidity, and bottom-material data suggest that the area in the vicinity of lower Kings Bay is accumulating deposits of suspended sediment transported from Cumberland Sound on the floodtide and from upper Kings Bay and the tidal marsh drained by Marianna Creek on the ebbtide. Suspended-sediment discharges computed for consecutive 13-hour ebbtides and floodtides showed that a net quantity of suspended sediment was transported seaward from upper Kings Bay and Marianna Creek. A net landward transport of suspended sediment computed at the St. Marys Entrance indicated areas seaward of St. Marys Entrance may be supplying sediment to the shoaling areas of the estuary, including lower Kings Bay. (USGS)

  3. Color ornaments and territory position in king penguins.

    Science.gov (United States)

    Keddar, Ismaël; Jouventin, Pierre; Dobson, F Stephen

    2015-10-01

    King penguins exhibit mutual color ornamentation of feathers and beak color. They breed in dense colonies and produce a single chick every 2 years. Thus, males and females must choose partners carefully to be reproductively successful, and auricular patches of males and UV coloration of beak spots have been shown to influence mate choice. Position in the breeding colony is also important to reproductive success, with pairs on the edge of the colony less successful than those in the center. We studied the mutual ornaments, individual condition, and position of pairs in their breeding colony. Males were significantly larger than females in size, body mass, and auricular patch size. Within pairs, auricular patch size of males and females were significantly correlated, and male auricular patch size and body mass were significantly associated, suggesting a link between this ornament and male body condition. Moving from the edge to the center of the colony, pairs had larger yellow-orange auricular patches, indicating a link between this ornament and settlement in higher quality territories in the center of the colony. Pairs were also less brightly brown colored on the breast and less saturated in UV color of the beak spot. Since we observed pairs that were settling for egg laying, location in the colony may have reflected aspects of pair condition, rather than later jockeying for positioning using ornaments as signals of behavioral dominance. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Maternal telomere length inheritance in the king penguin.

    Science.gov (United States)

    Reichert, S; Rojas, E R; Zahn, S; Robin, J-P; Criscuolo, F; Massemin, S

    2015-01-01

    Telomeres are emerging as a biomarker for ageing and survival, and are likely important in shaping life-history trade-offs. In particular, telomere length with which one starts in life has been linked to lifelong survival, suggesting that early telomere dynamics are somehow related to life-history trajectories. This result highlights the importance of determining the extent to which telomere length is inherited, as a crucial factor determining early life telomere length. Given the scarcity of species for which telomere length inheritance has been studied, it is pressing to assess the generality of telomere length inheritance patterns. Further, information on how this pattern changes over the course of growth in individuals living under natural conditions should provide some insight on the extent to which environmental constraints also shape telomere dynamics. To fill this gap partly, we followed telomere inheritance in a population of king penguins (Aptenodytes patagonicus). We tested for paternal and maternal influence on chick initial telomere length (10 days old after hatching), and how these relationships changed with chick age (at 70, 200 and 300 days old). Based on a correlative approach, offspring telomere length was positively associated with maternal telomere length early in life (at 10 days old). However, this relationship was not significant at older ages. These data suggest that telomere length in birds is maternally inherited. Nonetheless, the influence of environmental conditions during growth remained an important factor shaping telomere length, as the maternal link disappeared with chicks' age.

  5. Phytochemical Studies and Antioxidant Activities of Artocarpus scortechinii King

    Directory of Open Access Journals (Sweden)

    Norzafneza Mohd Arriffin

    2017-05-01

    Full Text Available Six known compounds identified as 4',5-dihydroxy-6,7-(2,2-dimethylpyrano-2'-methoxy-8-γ,γ-dimethylallyflavone (1, cudraflavone A (2, artocarpin(3, cycloartobiloxanthone (4, artonin E (5 and oxyresveratrol (6 were isolated from the stem barks of Artocapus scortechinii King. Another four compounds namely macakurzin C (7, flemichapparin A (8, luteolin (9 and apigenin (10 were isolated from the leaves. Structures of all pure compounds were elucidated spectroscopically using 1D NMR ( 1H, 13C, DEPT, 2D NMR (COSY, HMQC, HMBC, MS and FTIR, as well as by comparison with literature data. All isolated compounds were evaluated for their antioxidant capacities using 2,2-diphenyl-1-picrylhydrazyl (DPPH, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid (ABTS and ferric reducing antioxidant potential (FRAP assays. Luteolin (9 showed the best ability to act as DPPH free radical scavenger with IC 50 value of 9.51 µM. Luteolin (9 also exhibited the strongest scavenger and potent ferric ion reducer compared to other isolated compounds in the ABTS and FRAP assays with IC 50 value of 124.4µM and 4.07 ± 0.180 mM FRAP equivalent respectively.

  6. Lee de Forest King of Radio, Television, and Film

    CERN Document Server

    Adams, Mike

    2012-01-01

    Lee de Forest, Yale doctorate and Oscar winner, gave voice to the radio and the motion picture. Yet by the 1930s, after the radio and the Talkies were regular features of American life, Lee de Forest had seemingly lost everything. Why? Why didn’t he receive the recognition and acclaim he sought his entire life until years later in 1959, when he was awarded an Oscar? A lifelong innovator, Lee de Forest invented the three-element vacuum tube which he developed between 1906 and 1916 as a detector, amplifier, and oscillator of radio waves. As early as 1907, he was broadcasting music programming. In 1918, he began to develop a system for recording and playing back sound by using light patterns on motion picture film. In order to promote and demonstrate his process he made hundreds of short sound films, found theatres for their showing, and issued publicity to gain audiences for his invention. While he received many patents for this technology, he was ignored by the film industry. Lee de Forest, King of Radio, Te...

  7. Nonshivering thermogenesis and adaptation to fasting in king penguin chicks.

    Science.gov (United States)

    Duchamp, C; Barre, H; Delage, D; Rouanet, J L; Cohen-Adad, F; Minaire, Y

    1989-10-01

    The ability to develop nonshivering thermogenesis (NST) and the effect of fasting on thermogenic response to cold were studied in winter-acclimatized king penguin chicks. Metabolic rate (MR) and integrated electrical muscle activity were measured at different ambient temperatures. In cold-acclimatized (5 degrees C) fed chicks, shivering threshold temperature (STT) was 9.4 degrees C lower than lower critical temperature (LCT), indicating that NST (0.7 W/kg) occurs at moderate cold, whereas in control chicks fed and reared at 25 degrees C for 3 wk, LCT and STT were similar. Chicks reared in the cold and fasting for 3 wk or 4-5 mo (natural winter fast) developed an NST of 0.8 and 2.4 W/kg, respectively, despite the fast. In fasting chicks, the intercept of the metabolic curve with the abscissa at zero MR was far below body temperature, contrasting with the classic model for heat loss. Their low LCT indicates the capacity of a large reduction in convective conductance characteristic of diving animals and allows energy sparing in moderate cold. Below LCT, conductance reincreases progressively, leading to a steeper than expected slope of the metabolic curve and allowing preservation of a threshold temperature in the shell. These results show for the first time in a wild young bird the development of NST after cold acclimatization. Further, at the temperature of cold acclimatization, an energy-sparing mechanism is shown in response to long-term fast adaptation.

  8. Acanthamoeba Keratitis at the King Khaled Eye Specialist Hospital

    International Nuclear Information System (INIS)

    Al-Mezaine, H.; Al-Muteb, M.; Al-Motowa, S.; Wagoner, M. D.

    2005-01-01

    To quantify the number of cases and clinical courses of Acanthamoeba keratitis treated at the King Khaled Eye Specialist Hospital (KKESH) between December 1982 and May 2005, and to review their clinical course and response to medical and surgical therapy. Retrospective review of medical records of all patients with Acanthamoeba keratitis diagnosed by the KKESH Microbiology or Pathology or Pathology Laboratory since the opening of the hospital. During a period of over 22 years, only six cases of confirmed. Acanthamoeba keratitis were diagnosedand treated at KKESH. In two cases the diagnosis was made by corneal biopsy, while four cases required examination of a histopathology specimen obtained at the time of therapeutic keratoplasty to establish the diagnosis. One eye was cured by medical therapy, while five eyes required one (4eyes) or two (1 eye) therapeutic penetrating keratoplasty (PKP) to achieve a clinical cure. Three eyes achieved good visual acuity (20/40, 20/50, 20/60), one eye achieved fair visual acuity (20/160), and two eyes suffered profound visual loss (hand motions). The incidence of Acanthamoeba keratitis may be less in Saudi Arabia than reported in Western countries although the clinical is similarly complicated, with most cases requiring therapeutic keratoplasty for definitive education of the organism. (author)

  9. Color Gradient in the King Type Globular Cluster NGC 7089

    Directory of Open Access Journals (Sweden)

    Young-Jong Sohn

    1999-12-01

    Full Text Available We use BV CCD images to investigate the reality of the color gradient within a King type globular cluster NGC 7089. Surface photometry shows that there is a strong radial color gradient in the central region of the cluster in the sense of bluer center with the amplitude of -0.39 +/- 0.07 mag/arcsec2 in (B - V. In the outer region of the cluster, however, the radial color gradient shows a reverse case, i.e., redder toward the center. (B - V color profile which was derived from resolved stars in VGC 7089 field also shows a significant color gradient in the central region of the clusters, indicating that lights from the combination of red giant stars and blue horizontal branch stars cause the radial color gradient. Color gradient of the outer region of NGC 7089 may be due to the unresolved background of the cluster. Similar color gradients in the central area of clusters have been previously observed exserved exclusively in highly concentrated systems classified as post core collapse clusters. We caution, however, to confirm the reality of the color gradient from resolved stars, we need more accurate imaging data of the cluster with exceptional seeing condition because the effect of completeness correlates with local density of stars.

  10. Hypopharyngeal carcinoma: King Faisal Specialist Hospital and Research Center experience

    International Nuclear Information System (INIS)

    Mahasin, Z.; Khan, B.

    1996-01-01

    From 1975 to 1985, 202 patients with hypopharyngeal cancer were seen at King Faisal Specialist Hospital and Research Center (KFSHRC). The endoscopic investigation showed that 28.3% of these patients had postcricoid carcinoma; 19.85% had pyriform fossa carcinoma and 52.9% had involvement of both sites. The pathological diagnosis of all cases was squamous cell carcinoma type. The majority of the patients (62.98%) had T4 lesions, which showed a late presentation to KFSHRC. Information related to survival was available for a smaller number of patients to many lost-to-follow-up cases. The overall median survival time was 8.5 months (1-110 months). The survival rate for each site was calculated, as well as the staging of the disease and treatment modality used. It appeared that pyriform fossa (median 21 months) had the best survival rate. In addition the earlier the lesion was detected and the more aggressive the treatment applied, the better the survival rate. Fifty percent of the patients receiving radiation therapy and surgery had a five year survival arte. Factors other than smoking and/on drinking should be looked for in our community as predisposing to this disease in our population. (author)

  11. Réécriture des pièces de Shakespeare : l’enjeu de la modernité ? Rewriting Shakespeare’s Plays: the Challenge of Modernity?

    Directory of Open Access Journals (Sweden)

    Estelle Rivier

    2009-06-01

    Full Text Available Shakespeare’s works remain a reference when artists — either playwrights or stage professionals — aim at philosophising on human nature. These artists use the Shakespearean material to give vent to their own imagination and critical approach to the world they live in. Not surprisingly, Shakespeare’s plays have constantly been adapted on stage and in the cinema to comment upon contemporary facts and to voice either political or social concerns. But the same plays have also been the pretexts for other plays, written in modern English so as to serve new prospects. This study is based on the work of three twentieth-century writers – Arnold Wesker, Edward Bond and Tom Stoppard – who rewrote Shakespearean plays: The Merchant of Venice (The Merchant, 1977, King Lear (Lear, 1972 and Hamlet (Rosencrantz and Guildenstern are Dead, 1967. This article explores the way these plays were elaborated with reference to the original versions and why their authors decided to adapt the Elizabethan text.

  12. Overvåking av norsk kosthold - metoder og resultater

    Directory of Open Access Journals (Sweden)

    Lars Johansson

    2009-11-01

    Full Text Available  SAMMENDRAGKunnskap om endringer i matvarenes sammensetning og befolkningens kosthold er grunnleggende for utformingog oppfølging av en helsefremmende mat- og ernæringspolitikk. Dagens system for overvåking avkostholdet bygger først og fremst på en matvaredatabase og opplysninger om forbruket av matvarer fra tretyper datasett; matforsyningsstatistikk, forbruksundersøkelser og kostholdsundersøkelser. Det avgis årlig envurdering av utviklingen i norsk kosthold i forhold til mat- og ernæringspolitiske målsettinger. Det norskesystemet for overvåking av kostholdet er blitt betydelig styrket i løpet av 1990-årene ved innføringen avregelmessige kostholdsundersøkelser blant landsrepresentative utvalg av befolkningen i ulike aldersgrupperog økte ressurser til analyse av næringsinnholdet i matvarer. Det er imidlertid beskjedent sammenlignet meddatainnsamlingen i land som USA og Storbritannia. Det norske overvåkingssystemet er forsatt i enutviklingsfase, og det må justeres og kompletteres etter hvert. Dessuten vil det arbeides med å kvalitetssikredatainnsamlingen.Johansson L. Surveillance of the diet in Norway – methods and results.Nor J Epidemiol ENGLISH SUMMARYKnowledge about changes in composition and intake of foods, as well as changes in the prevalence of dietrelatedhealth problems is fundamental for an effective food and nutrition policy. The National Council onNutrition and Physical Activity is responsible for evaluating changes in the diet. Annually the Council publishesreports about trends in the Norwegian diet, and suggests measures to improve the diet. The Council, incooperation with the National Food Authority and the Institute for Nutrition Research, University of Oslo,has established a national food and dietary surveillance system. This system is mainly based on a fooddatabase and food consumption data. The food consumption data include three principally different datasets: food supplies, household consumption surveys

  13. King penguins adjust their diving behaviour with age.

    Science.gov (United States)

    Le Vaillant, Maryline; Wilson, Rory P; Kato, Akiko; Saraux, Claire; Hanuise, Nicolas; Prud'homme, Onésime; Le Maho, Yvon; Le Bohec, Céline; Ropert-Coudert, Yan

    2012-11-01

    Increasing experience in long-lived species is fundamental to improving breeding success and ultimately individual fitness. Diving efficiency of marine animals is primarily determined by their physiological and mechanical characteristics. This efficiency may be apparent via examination of biomechanical performance (e.g. stroke frequency and amplitude, change in buoyancy or body angle, etc.), which itself may be modulated according to resource availability, particularly as a function of depth. We investigated how foraging and diving abilities vary with age in a long-lived seabird. During two breeding seasons, small accelerometers were deployed on young (5 year old) and older (8/9 year old) brooding king penguins (Aptenodytes patagonicus) at the Crozet Archipelago, Indian Ocean. We used partial dynamic body acceleration (PDBA) to quantify body movement during dive and estimate diving cost. During the initial part of the descent, older birds exerted more effort for a given speed but younger penguins worked harder in relation to performance at greater depths. Younger birds also worked harder per unit speed for virtually the whole of the ascent. We interpret these differences using a model that takes into account the upthrust and drag to which the birds are subjected during the dive. From this, we suggest that older birds inhale more at the surface but that an increase in the drag coefficient is the factor leading to the increased effort to swim at a given speed by the younger birds at greater depths. We propose that this higher drag may be the result of young birds adopting less hydrodynamic postures or less direct trajectories when swimming or even having a plumage in poorer condition.

  14. Review of records and notes on King Penguin (Aptenodytes patagonicus) and Rockhopper Penguin (Eudyptes chrysocome) in Brazil

    OpenAIRE

    Barquete, Viviane; Bugoni, Leandro; Silva-Filho, Rodolfo P.; Adornes, Andréa C.

    2006-01-01

    A review of previous findings and new records of King Penguin (Aptenodytes patagonicus) and Rockhopper Penguin (Eudyptes chrysocome) on the Brazilian coast is presented. In total there are six records of the King Penguin and ten records of the Rockhopper Penguin. Juvenile and adults of both species were found stranded mostly on Rio Grande do Sul coast, southern Brazil. Records of King Penguins are restricted to the summer season, while records of Rockhopper Penguins are mostly during winter. ...

  15. An ideal for leadership - Psalm 72: The (wise king - Royal mediation of God�s universal reign

    Directory of Open Access Journals (Sweden)

    D. J. Human

    2002-08-01

    Full Text Available Psalm 72 propounds illuminating theological perspectives on leadership. The central figure in the psalm is the king. Throughout the Ancient Near East the king played a distinctive role, not only in contemporary politics, but also in religious life. Despite several differences from the other nations, kingship in Israel was rooted in the worldview of the ancient East. Yahweh, like other gods, commissioned the king for his tasks. The wise king in Israel, who alludes in Psalm 72 to the figure of Solomon, is obliged to rule with justice in order to maintain peace and prosperity in society.

  16. Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial.

    Science.gov (United States)

    Hofmeijer, Jeannette; Kappelle, L Jaap; Algra, Ale; Amelink, G Johan; van Gijn, Jan; van der Worp, H Bart

    2009-04-01

    Patients with space-occupying hemispheric infarctions have a poor prognosis, with case fatality rates of up to 80%. In a pooled analysis of randomised trials, surgical decompression within 48 h of stroke onset reduced case fatality and improved functional outcome; however, the effect of surgery after longer intervals is unknown. The aim of HAMLET was to assess the effect of decompressive surgery within 4 days of the onset of symptoms in patients with space-occupying hemispheric infarction. Patients with space-occupying hemispheric infarction were randomly assigned within 4 days of stroke onset to surgical decompression or best medical treatment. The primary outcome measure was the modified Rankin scale (mRS) score at 1 year, which was dichotomised between good (0-3) and poor (4-6) outcome. Other outcome measures were the dichotomy of mRS score between 4 and 5, case fatality, quality of life, and symptoms of depression. Analysis was by intention to treat. This trial is registered, ISRCTN94237756. Between November, 2002, and October, 2007, 64 patients were included; 32 were randomly assigned to surgical decompression and 32 to best medical treatment. Surgical decompression had no effect on the primary outcome measure (absolute risk reduction [ARR] 0%, 95% CI -21 to 21) but did reduce case fatality (ARR 38%, 15 to 60). In a meta-analysis of patients in DECIMAL (DEcompressive Craniectomy In MALignant middle cerebral artery infarction), DESTINY (DEcompressive Surgery for the Treatment of malignant INfarction of the middle cerebral arterY), and HAMLET who were randomised within 48 h of stroke onset, surgical decompression reduced poor outcome (ARR 16%, -0.1 to 33) and case fatality (ARR 50%, 34 to 66). Surgical decompression reduces case fatality and poor outcome in patients with space-occupying infarctions who are treated within 48 h of stroke onset. There is no evidence that this operation improves functional outcome when it is delayed for up to 96 h after stroke onset

  17. Behavioral and physiological significance of minimum resting metabolic rate in king penguins.

    Science.gov (United States)

    Halsey, L G; Butler, P J; Fahlman, A; Woakes, A J; Handrich, Y

    2008-01-01

    Because fasting king penguins (Aptenodytes patagonicus) need to conserve energy, it is possible that they exhibit particularly low metabolic rates during periods of rest. We investigated the behavioral and physiological aspects of periods of minimum metabolic rate in king penguins under different circumstances. Heart rate (f(H)) measurements were recorded to estimate rate of oxygen consumption during periods of rest. Furthermore, apparent respiratory sinus arrhythmia (RSA) was calculated from the f(H) data to determine probable breathing frequency in resting penguins. The most pertinent results were that minimum f(H) achieved (over 5 min) was higher during respirometry experiments in air than during periods ashore in the field; that minimum f(H) during respirometry experiments on water was similar to that while at sea; and that RSA was apparent in many of the f(H) traces during periods of minimum f(H) and provides accurate estimates of breathing rates of king penguins resting in specific situations in the field. Inferences made from the results include that king penguins do not have the capacity to reduce their metabolism to a particularly low level on land; that they can, however, achieve surprisingly low metabolic rates at sea while resting in cold water; and that during respirometry experiments king penguins are stressed to some degree, exhibiting an elevated metabolism even when resting.

  18. Mandatory menu labeling in one fast-food chain in King County, Washington.

    Science.gov (United States)

    Finkelstein, Eric A; Strombotne, Kiersten L; Chan, Nadine L; Krieger, James

    2011-02-01

    As part of a comprehensive effort to stem the rise in obesity, King County, Washington, enforced a mandatory menu-labeling regulation requiring all restaurant chains with 15 or more locations to disclose calorie information at the point of purchase beginning in January 2009. The purpose of this study is to quantify the impact of the King County regulation on transactions and purchasing behavior at one Mexican fast-food chain with locations within and adjacent to King County. To examine the effect of the King County regulation, a difference-in-difference approach was used to compare total transactions and average calories per transaction between seven King County restaurants and seven control locations focusing on two time periods: one period immediately following the law until the posting of drive-through menu boards (January 2009 to July 2009) and a second period following the drive-through postings (August 2009 through January 2010). Analyses were conducted in 2010. No impact of the regulation on purchasing behavior was found. Trends in transactions and calories per transaction did not vary between control and intervention locations after the law was enacted. In this setting, mandatory menu labeling did not promote healthier food-purchasing behavior. Copyright © 2011 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  19. Lenke and King classification systems for adolescent idiopathic scoliosis: interobserver agreement and postoperative results

    Directory of Open Access Journals (Sweden)

    Hosseinpour-Feizi H

    2011-12-01

    Full Text Available Hojjat Hosseinpour-Feizi, Jafar Soleimanpour, Jafar Ganjpour Sales, Ali ArzroumchilarDepartment of Orthopedics, Shohada Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranPurpose: The aim of this study was to investigate the interobserver agreement of the Lenke and King classifications for adolescent idiopathic scoliosis, and to compare the results of surgery performed based on classification of the scoliosis according to each of these classification systems.Methods: The study was conducted in Shohada Hospital in Tabriz, Iran, between 2009 and 2010. First, a reliability assessment was undertaken to assess interobserver agreement of the Lenke and King classifications for adolescent idiopathic scoliosis. Second, postoperative efficacy and safety of surgery performed based on the Lenke and King classifications were compared. Kappa coefficients of agreement were calculated to assess the agreement. Outcomes were compared using bivariate tests and repeated measures analysis of variance.Results: A low to moderate interobserver agreement was observed for the King classification; the Lenke classification yielded mostly high agreement coefficients. The outcome of surgery was not found to be substantially different between the two systems.Conclusion: Based on the results, the Lenke classification method seems advantageous. This takes into consideration the Lenke classification’s priority in providing details of curvatures in different anatomical surfaces to explain precise intensity of scoliosis, that it has higher interobserver agreement scores, and also that it leads to noninferior postoperative results compared with the King classification method.Keywords: test reliability, scoliosis classification, postoperative efficacy, adolescents

  20. Lenke and King classification systems for adolescent idiopathic scoliosis: interobserver agreement and postoperative results.

    Science.gov (United States)

    Hosseinpour-Feizi, Hojjat; Soleimanpour, Jafar; Sales, Jafar Ganjpour; Arzroumchilar, Ali

    2011-01-01

    The aim of this study was to investigate the interobserver agreement of the Lenke and King classifications for adolescent idiopathic scoliosis, and to compare the results of surgery performed based on classification of the scoliosis according to each of these classification systems. The study was conducted in Shohada Hospital in Tabriz, Iran, between 2009 and 2010. First, a reliability assessment was undertaken to assess interobserver agreement of the Lenke and King classifications for adolescent idiopathic scoliosis. Second, postoperative efficacy and safety of surgery performed based on the Lenke and King classifications were compared. Kappa coefficients of agreement were calculated to assess the agreement. Outcomes were compared using bivariate tests and repeated measures analysis of variance. A low to moderate interobserver agreement was observed for the King classification; the Lenke classification yielded mostly high agreement coefficients. The outcome of surgery was not found to be substantially different between the two systems. Based on the results, the Lenke classification method seems advantageous. This takes into consideration the Lenke classification's priority in providing details of curvatures in different anatomical surfaces to explain precise intensity of scoliosis, that it has higher interobserver agreement scores, and also that it leads to noninferior postoperative results compared with the King classification method.

  1. Arctic observers: Richard King, monogenism and the historicisation of Inuit through travel narratives.

    Science.gov (United States)

    Sera-Shriar, Efram

    2015-06-01

    In 1848 the ethnologist, surgeon and Arctic explorer Richard King (1810-1876) published a three-part series on Inuit in the Journal of the Ethnological Society of London. This series provided a detailed history of Inuit from the eleventh century to the early nineteenth century. It incorporated a mixture of King's personal observations from his experience travelling to the Arctic as a member of George Back's expedition (1833-1835), and the testimonies of other contemporary and historical actors who had written on the subject. The aim was to historicise Inuit through the use of travel reports and show persistent features among the race. King was a monogenist and his sensitive recasting of Inuit was influenced by his participation in a research community actively engaged in humanitarian and abolitionist causes. The physician and ethnologist Thomas Hodgkin (1798-1866) argued that King's research on Inuit was one of the best ethnological approaches to emulate and that it set the standard for the nascent discipline. If we are to take seriously Hodgkin's claim, we should look at how King constructed his depiction of Inuit. There is much to be gained by investigating the practices of nineteenth-century ethnologists because it strengthens our knowledge of the discipline's past and shows how modern understandings of races were formed. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Mixed connective tissue disease: The King Faisal Specialist Hospital experience

    International Nuclear Information System (INIS)

    Al-Rayes, H.; Al-Sheikh, A.; Al-Dalaan, A.; Al-Saleh, S.

    2002-01-01

    The aim of this study was to assess the clinical presentation, complications and serological analysis of mixed connective tissue disease (MCTD) at King Faisal Specialist Hospital and Research Centre (KFSHRC), and to determine the long-term clinical and immunologic outcomes. This was a retrospective study with prospective follow-up of 18 patients with MCTD who were followed at KFSHRC between 1982 and 1999. The age at onset of the disease ranged from 6 to 44 years, with mean age of 17.9 years. The female to male ratio was 2.5:1 and the mean follow-up time was 5 years. The most frequent presenting symptoms were arthralgia in all patients, Raynaud's phenomenon in 16 patients (88%) and swollen hands in 11 patients (61%). Arthritis was seen in 12 patients in (67%) and definite myositis in 10 patients (58%). The most common skin rashes encountered included lupus-like rash in 8 patients (44%) and cutaneous vasculitis in 5 patients (28%). Pulmonary hypertension occurred in 4 patients (22%). Other clinical manifestations encountered were esophageal hypomotility in 10 patients (56%), myocarditis in 2 patients (11%) and proteinurea in 2 patients (11%), while various neurological manifestations were present in 7 patients (39%). All patients exhibited higher titer of ANA and anti-nRNP antibodies. Five of the 18 patients (28%) had marked reduction in the anti-nRNP during remission. Following treatment, features of inflammation as well as Raynaud's phenomenon and esophageal hypomotility diminished, while pulmonary hypertension persisted. A favorable outcome was observed in 12 patients (67%), 3 patients (17%) had continued active disease, while 3 patients (17%) died, with death related to pulmonary hypertension occurring in 2 patients (11%). The studied patients demonstrated the typical clinical and serological findings of MCTD, which support the correlation between anti-nRNP antibody specificities and MCTD. Autoantibody reactivity against nRNP polypeptides tends to regress during

  3. Modern sedimentation patterns in Potter Cove, King George Island, Antarctica

    Science.gov (United States)

    Hass, H. Christian; Kuhn, Gerhard; Wölfl, Anne-Cathrin; Wittenberg, Nina; Betzler, Christian

    2013-04-01

    IMCOAST among a number of other initiatives investigates the modern and the late Holocene environmental development of south King George Island with a strong emphasis on Maxwell Bay and its tributary fjord Potter Cove (maximum water depth: about 200 m). In this part of the project we aim at reconstructing the modern sediment distribution in the inner part of Potter Cove using an acoustic ground discrimination system (RoxAnn) and more than136 ground-truth samples. Over the past 20 years the air temperatures in the immediate working area increased by more than 0.6 K (Schloss et al. 2012) which is less than in other parts of the West Antarctic Peninsula (WAP) but it is still in the range of the recovery of temperatures from the Little Ice Age maximum to the beginning of the 20th century. Potter Cove is a small fjord characterized by a series of moraine ridges produced by a tidewater glacier (Fourcade Glacier). Presumably, the farthest moraine is not much older than about 500 years (LIA maximum), hence the sediment cover is rather thin as evidenced by high resolution seismic data. Since a few years at least the better part of the tidewater glacier retreated onto the island's mainland. It is suggested that such a fundamental change in the fjord's physiography has also changed sedimentation patterns in the area. Potter Cove is characterized by silty-clayey sediments in the deeper inner parts of the cove. Sediments are coarser (fine to coarse sands and boulders) in the shallower areas; they also coarsen from the innermost basin to the mouth of the fjord. Textural structures follow the seabed morphology, i.e. small v-shaped passages through the moraine ridges. The glacier still produces large amounts of turbid melt waters that enter the cove at various places. We presume that very fine-grained sediments fall out from the meltwater plumes and are distributed by mid-depth or even bottom currents, thus suggesting an anti-estuarine circulation pattern. Older sediments that are

  4. Five analogies between a King's Speech treatment and contemporary play therapies.

    Science.gov (United States)

    Terr, Lenore C

    2012-01-01

    Psychiatric patients frequently respond positively to play therapy, which may rely on psychoanalytic, Jungian, cognitive-behavioral, familial, school-based, or other theories. I wished to determine if there were unifying principles that tie together these various types of play treatments. The fact-based film, The King's Speech, vividly illustrates play utilized by Lionel Logue in his speech treatment (1926-1939) of the future King of England. In the film I found five analogies to the play therapy I employ in office practice. The play scenes in The King's Speech point to five unifying principles among contemporary play therapies: (1) the crucial nature of the relationship, (2) the centrality of having fun, (3) the occasional reliance on others, (4) the interjection of pithy talk, and (5) the usefulness of a little drama. No matter what theory a play therapist ascribes to, these five unifying principles should be kept in mind during treatment.

  5. Archeology in Medicine: Digging up into the tophi of Popes, Dukes and Kings

    Directory of Open Access Journals (Sweden)

    G. Ceccarelli

    2011-09-01

    Full Text Available According to an Anglo-Saxon pun, “gout is the king of diseases and the disease of Kings”. In fact, it is well-known that in past times a quantity of famous persons, including Kings and Popes, were affected with this rheumatic disorder. In this paper biographical anecdotes on several Popes (Pius III, Julius II, Julius III, Clement VIII, Innocent XI, Clement XII and Pius VIII, King George IV and Queen Anne of England, as well as on some members of the Lorraine lineage, all suffering from gout, are sketched out. These historical data are briefly discussed in relation to the celebrated Hippocrates’s aphorisms on gout.

  6. King penguin population on Macquarie Island recovers ancient DNA diversity after heavy exploitation in historic times.

    Science.gov (United States)

    Heupink, Tim H; van den Hoff, John; Lambert, David M

    2012-08-23

    Historically, king penguin populations on Macquarie Island have suffered greatly from human exploitation. Two large colonies on the island were drastically reduced to a single small colony as a result of harvesting for the blubber oil industry. However, recent conservation efforts have resulted in the king penguin population expanding in numbers and range to recolonize previous as well as new sites. Ancient DNA methods were used to estimate past genetic diversity and combined with studies of modern populations, we are now able to compare past levels of variation with extant populations on northern Macquarie Island. The ancient and modern populations are closely related and show a similar level of genetic diversity. These results suggest that the king penguin population has recovered past genetic diversity in just 80 years owing to conservation efforts, despite having seen the brink of extinction.

  7. Morte e ressurreição: uma reflexão sobre as adaptações fílmicas "Dom Quixote" e "Hamlet", de Kozintsev

    Directory of Open Access Journals (Sweden)

    Thayane Morais Silva

    2017-03-01

    Full Text Available RESUMOAo considerar os “400 anos da morte de Shakespeare e Cervantes”, é impossível não associar as obras desses respectivos autores à questão da autoria, tema tão recorrente nos Estudos Literários, amplamente discutido por Barthes Foucault e Agamben. Se passaram 400 anos desde a morte do corpo, e não da morte do legado artístico –é sempre bom lembrar, desses dois escritores.  Entretanto, diante de tantas reproduções técnicas que desencadearam a destruição da aura da obra de arte, propomos estabelecer uma relação entre a morte autoral desses dois autores e os conceitos que Walter Benjamin delineou para esclarecer a situação da obra de arte na era de sua reprodutibilidade técnica. A fim de exemplificar como a autoria de Cervantes e de Shakespeare é mortificada a partir de suas próprias obras, iremos investigar duas adaptações cinematográficas, Dom Quixote e Hamlet, ambas dirigidas por Grigori Kozintsev.PALAVRAS-CHAVE: Shakespeare; Cervantes; Autoria; Reprodutibilidade técnica; Adaptação cinematográfica.

  8. DE-MYTHOLOGIZING THE BARD: APPROPRIATION OF SHAKESPEARE IN TOM STOPPARD’S DOGG’S HAMLET, CAHOOT’S MACBETH

    Directory of Open Access Journals (Sweden)

    Ifeta Ciric-Fazlija

    2014-11-01

    Full Text Available One of the most entrenched myths that dramatic authors need to contest and adjust to is the Shakespeare myth, a long-lasting and all-pervasive influence that Shakespeare’s name and texts have exerted since the late 16th century, being perceived as “represent[ing] truths that transcend particular circumstances” (Sinfield, 1998: 129. In order to be actively involved in the “making of culture” (Sinfield, 1998: 128 and for the purpose of establishing and (redefining one’s own position within and against the canonical (transnational texts, many British dramatists, including Tom Stoppard, have alluded to, quoted, or incorporated portions of Shakespeare’s plays within their own, or even reconstituted them completely. This paper discusses the manner in which Stoppard appropriates Shakespeare’s Hamlet and Macbeth – probably his best known and most frequently staged and adapted tragedies – in order to question the importance of both the author and his work within the context of contemporary culture and society.

  9. USING REMOTE SENSING AND GIS TECHNIQUES TO DETECT CHANGES TO THE PRINCE ALFRED HAMLET CONSERVATION AREA IN THE WESTERN CAPE, SOUTH AFRICA

    Directory of Open Access Journals (Sweden)

    P. Duncan

    2016-06-01

    Full Text Available Understanding and identifying the spatial-temporal changes in the natural environment is crucial for monitoring and evaluating conservation efforts, as well as understanding the impact of human activities on natural resources, informing responsible land management, and promoting better decision-making. Conservation areas are often under pressure from expanding farming and related industry, invasive alien vegetation, and an ever-increasing human settlement footprint. This study focuses on detecting changes to the Prince Alfred Hamlet commonage, near Ceres in the Cape Floral Kingdom. It was chosen for its high conservation value and significance as a critical water source area. The study area includes a fast-growing human settlement footprint in a highly productive farming landscape. There are conflicting development needs as well as risks to agricultural production, and both of these threaten the integrity of the ecosystems which supply underlying services to both demands on the land. Using a multi-disciplinary approach and high-resolution satellite imagery, land use and land cover changes can be detected and classified, and the results used to support the conservation of biodiversity and wildlife, and protect our natural resources. The aim of this research is to study the efficacy of using remote sensing and GIS techniques to detect changes to critical conservation areas where disturbances can be understood, and therefore better managed and mitigated before these areas are degraded beyond repair.

  10. Age and growth of the mutton hamlet Alphestes afer, with a review of the size and age of sex change among epinephelids.

    Science.gov (United States)

    Marques, S; Ferreira, B P

    2016-07-01

    This paper presents results on the age, growth and population structure of a small grouper, the mutton hamlet Alphestes afer, and discusses the observed size and age structure patterns in relation to reproductive strategies among the epinephelids. Ages were determined by examination of sectioned otoliths, which showed a distinct pattern of alternating translucent and opaque zones that formed annually, as validated with tetracycline labelling. The von Bertalanffy growth function was adjusted to the length-at-age data of the males and females, but no significant differences were observed between the resulting parameters. The females, however, were older at given sizes and attained larger sizes and ages, with a maximum observed longevity of 13 years and a total length (LT ) of 26 cm, while the males attained maximum longevities of only 10 years and a 22 cm maximum LT . The LT and age range for the sex change was 16-25 cm and 3-11 years. The total mortality rate (Z) was estimated to be 0·55 for females and 0·82 for males. With the males younger and smaller than the females, this species differed from the pattern commonly observed for protogynous epinephelids. Males had slower growth after maturation, probably due to energy allocation to sperm production during sexual development. This study shows that demography is an important tool to understand the pathways for reproductive strategies in grouper populations. © 2016 The Fisheries Society of the British Isles.

  11. Using Remote Sensing and GIS Techniques to Detect Changes to the Prince Alfred Hamlet Conservation Area in the Western Cape, South Africa

    Science.gov (United States)

    Duncan, P.; Lewarne, M.

    2016-06-01

    Understanding and identifying the spatial-temporal changes in the natural environment is crucial for monitoring and evaluating conservation efforts, as well as understanding the impact of human activities on natural resources, informing responsible land management, and promoting better decision-making. Conservation areas are often under pressure from expanding farming and related industry, invasive alien vegetation, and an ever-increasing human settlement footprint. This study focuses on detecting changes to the Prince Alfred Hamlet commonage, near Ceres in the Cape Floral Kingdom. It was chosen for its high conservation value and significance as a critical water source area. The study area includes a fast-growing human settlement footprint in a highly productive farming landscape. There are conflicting development needs as well as risks to agricultural production, and both of these threaten the integrity of the ecosystems which supply underlying services to both demands on the land. Using a multi-disciplinary approach and high-resolution satellite imagery, land use and land cover changes can be detected and classified, and the results used to support the conservation of biodiversity and wildlife, and protect our natural resources. The aim of this research is to study the efficacy of using remote sensing and GIS techniques to detect changes to critical conservation areas where disturbances can be understood, and therefore better managed and mitigated before these areas are degraded beyond repair.

  12. Religión y Paz en Martin Luther King Jr.

    OpenAIRE

    Mussio, Ria Stacy

    2016-01-01

    Esta tesis pretende mostrar el rol integral que la religión desempeñaba en la obtención de los derechos civiles para los afroamericanos y, también en el logro de la paz positiva. Martin Luther King Jr. y la mayoría de los manifestantes del movimiento eran cristianos, poniendo su fe en Dios, para el pleno disfrute de sus derechos humanos. King Jr., anclado en su fe, impulsó el avance de los derechos civiles, mediante la resistencia no violenta. El primer capítulo tiene como finalidad orientar ...

  13. Overvåking av jordboende sopp i Røsskleiva NR, Bamble 2016

    OpenAIRE

    Brandrud, Tor Erik; Dima, Bàlint

    2017-01-01

    Brandrud, T.E. & Dima, B. 2017. Overvåking av jordboende sopp i Røsskleiva NR, Bamble 2016. – NINA Kortrapport 80. 15 s. Kartlegging (start av overvåking) av habitat-spesifikke, jordboende kalksopper i nordre del av Røsskleiva NR ble gjennomført i 2016, før oppstart av skjøtselstiltak med storfébeiting. Tilsammen 27 habitat-spesifikke arter, inkludert 18 rødlistede arter ble registrert i løpet av to registreringsrunder i 2016. Funnene fordelte seg på 10 kalkbarskogsopper, 5 kalklinde-skogs...

  14. The Role of Continuous Education Programs Organized by Saudi Universities in Literacy--A Case Study of King Saud University

    Science.gov (United States)

    Al Rawaf, Haya Saad Abdulla; Fattah, Azza Khalil Abdel; Megeid, Fadia Yousif Abdel; Nazmy, Rania Mohammed Aziz; Alarifi, Sarah Nasser; Al Sulaihm, Hind Sulaiman

    2017-01-01

    This study aims at highlighting the role of Continuous Education Programs at the Saudi Universities in Religious, Social, and Health Literacy; King Saud University was taken as an example. To achieve the goals of the study two questionnaires were distributed among two samples from King Saud University; (101) of students, and (9) of continuous…

  15. The Role of Authors in the “Uruk List of Kings and Sages”: Canonization and Cultural Contact

    DEFF Research Database (Denmark)

    Helle, Sophus

    2018-01-01

    The so-called "Uruk List of Kings and Sages" includes a selection of (pseudo-)historical figures known from other sources as the authors of literary and scholarly works. These authors are placed alongside famous kings and mythical sages, in a synoptic and schematic overview of cuneiform culture...

  16. "I Just Want to Do God's Will:" Teaching Martin Luther King, Jr. as a Religious Leader

    Science.gov (United States)

    Neumann, David

    2018-01-01

    Teachers often respond to the perils of teaching about religion by simply avoiding the subject. An investigation of secondary lesson plans on three prominent Martin Luther King, Jr. websites reveals little attention to the ideology of the civil rights movement, especially those touching on religious ideas. Ignoring King's religious views risks…

  17. Radiological Instrumentation Assessment for King County Wastewater Treatment Division

    International Nuclear Information System (INIS)

    Strom, Daniel J.; McConn, Ronald J.; Brodzinski, Ronald L.

    2005-01-01

    The King County Wastewater Treatment Division (WTD) have concern about the aftermath of a radiological dispersion event (RDE) leading to the introduction of significant quantities of radioactive material into its combined sanitary and storm sewer system. Radioactive material could come from the use of a radiological dispersion device (RDD). RDDs include 'dirty bombs' that are not nuclear detonations but are explosives designed to spread radioactive material. Radioactive material also could come from deliberate introduction or dispersion of radioactive material into the environment, including waterways and water supply systems. Volume 2 of PNNL-15163 assesses the radiological instrumentation needs for detection of radiological or nuclear terrorism, in support of decisions to treat contaminated wastewater or to bypass the West Point Treatment Plant (WPTP), and in support of radiation protection of the workforce, the public, and the infrastructure of the WPTP. Fixed radiation detection instrumentation should be deployed in a defense-in-depth system that provides (1) early warning of significant radioactive material on the way to the WPTP, including identification of the radionuclide(s) and estimates of the soluble concentrations, with a floating detector located in the wet well at the Interbay Pump Station and telemetered via the internet to all authorized locations; (2) monitoring at strategic locations within the plant, including (2a) the pipe beyond the hydraulic ram in the bar screen room; (2b) above the collection funnels in the fine grit facility; (2c) in the sampling tank in the raw sewage pump room; and (2d) downstream of the concentration facilities that produce 6% blended and concentrated biosolids. Engineering challenges exist for these applications. It is necessary to deploy both ultra-sensitive detectors to provide early warning and identification and detectors capable of functioning in high-dose rate environments that are likely under some scenarios

  18. Chiari-like malformation and syringomyelia in cavalier King Charles spaniels

    NARCIS (Netherlands)

    Rusbridge, C.

    2007-01-01

    This thesis is the cumulation of over a decade of study into the pathogenesis and treatment Chiari-like malformation and syringomyelia (CM/SM) in the cavalier King Charles spaniel (CKCS). Chiari-like malformation is a condition where the brain is too big for the skull and is crushed and pushed out

  19. King Cotton's Lasting Legacy of Poverty and Southern Region Contemporary Conditions

    Science.gov (United States)

    Guthrie, James W.; Peevely, Gary

    2010-01-01

    One hundred fifty years ago, cotton was considered as the king of all United States' agricultural exports. Cotton's dollar value far exceeded that of any other mid-19th-century United States trade item, much more than tobacco, fish, forest products, raw materials for manufacturing, or manufactured items. Indeed, in the mid-19th century, cotton was…

  20. Coretta Scott King Award Winner Javaka Steptoe Stands Tall "In Daddy's Arms."

    Science.gov (United States)

    Peck, Jackie; Hendershot, Judy

    1999-01-01

    Offers an interview with artist and author Javaka Steptoe, winner of the Coretta Scott King award for his book "In Daddy's Arms I Am Tall: African Americans Celebrating Fathers." Discusses his background in the arts, the variety of media he uses, how he begins thinking about his illustrations, his work with children's art, and aspects of his work.…

  1. Willingness to Communicate in English: A Case Study of EFL Students at King Khalid University

    Science.gov (United States)

    Mahdi, Dawood Ahmed

    2014-01-01

    The main purpose of learning a foreign language is to use it for meaningful and effective communication both inside and outside the classroom. This paper is devoted to identifying the main communication difficulties faced by EFL students at King Khalid University (KKU) and exploring the reasons that lie behind these difficulties. The paper…

  2. The Rule of Law and Civil Disobedience: The Case behind King's Letter from a Birmingham Jail

    Science.gov (United States)

    Kaplan, Howard

    2013-01-01

    Fifty years ago, the Reverend Dr. Martin Luther King Jr. wrote his "Letter from a Birmingham Jail." In exploring the story of the events behind the essay, and the Supreme Court case that resulted, "Walker v. Birmingham", 399 U.S. 307 (1967), educators will find a pedagogically powerful lens through which to review the seminal…

  3. AFSC/RACE/SAP/Long: Effects of ocean acidification on blue king crab

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This is data from a laboratory experiment in which blue king crab juveniles were held at three different pHs (ambient, pH 7.8, and pH 7.5) for a year. Growth,...

  4. Prescribed burning in the Kings River Ecosystem Project Area: lessons learned

    Science.gov (United States)

    David S. McCandliss

    2002-01-01

    The prescribed fire program on the Sierra National Forest is in its infancy. Prescription burning was initiated in 1994 in two 32,000-acre watersheds in the Kings River District of the Sierra National Forest. Primary objectives are to return fire to a more historical role in forest ecosystems and to provide opportunities for scientists from the Pacific Southwest...

  5. Endotracheal Intubation Using the Macintosh Laryngoscope or KingVision Video Laryngoscope during Uninterrupted Chest Compression

    Directory of Open Access Journals (Sweden)

    Ewelina Gaszynska

    2014-01-01

    Full Text Available Objective. Advanced airway management, endotracheal intubation (ETI, during CPR is more difficult than, for example, during anesthesia. However, new devices such as video laryngoscopes should help in such circumstances. The aim of this study was to assess the performance of the KingVision video laryngoscopes in a manikin cardiopulmonary resuscitation (CPR scenario. Methods. Thirty students enrolled in the third year of paramedic school took part in the study. The simulated CPR scenario was ETI using the standard laryngoscope with a Macintosh blade (MCL and ETI using the KingVision video laryngoscope performed during uninterrupted chest compressions. The primary endpoints were the time needed for ETI and the success ratio. Results. The mean time required for intubation was similar for both laryngoscopes: 16.6 (SD 5.11, median 15.64, range 7.9–27.9 seconds versus 17.91 (SD 5.6, median 16.28, range 10.6–28.6 seconds for the MCL and KingVision, respectively (P=0.1888. On the first attempt at ETI, the success rate during CPR was comparable between the evaluated laryngoscopes: P=0.9032. Conclusion. The KingVision video laryngoscope proves to be less superior when used for endotracheal intubation during CPR compared to the standard laryngoscope with a Mackintosh blade. This proves true in terms of shortening the time needed for ETI and increasing the success ratio.

  6. Multiple Intelligences Patterns of Students at King Saud University and Its Relationship with Mathematics' Achievement

    Science.gov (United States)

    Kandeel, Refat A. A.

    2016-01-01

    The purpose of this study was to determine the multiple intelligences patterns of students at King Saud University and its relationship with academic achievement for the courses of Mathematics. The study sample consisted of 917 students were selected a stratified random manner, the descriptive analysis method and Pearson correlation were used, the…

  7. His Majesty King Abdullah II of the Hashemite Kingdom of Jordan

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    Left to right : King Abdullah II of Jordan visiting CERN with Luciano Maiani, Director-General of CERN, Maurice Bourquin (behind), President of the CERN Council, and Herwig Schopper, President of the SESAME Council and former Director-General of CERN.

  8. Has the Dream Been Fulfilled? Dr. Martin Luther King, Jr. & President Barack Hussein Obama

    Science.gov (United States)

    Robinson, Nichelle Boyd; Moore, Virginia J.; Williams-Black, Thea H.

    2015-01-01

    Equality for all was the dream of Dr. Martin Luther King, Jr. and he knowingly laid the foundation for and inspired the first African-American President of the United States of America, Barack Hussein Obama, who also had the dream of "Change" for America. These men exhibited how working together can make dreams become reality. For the…

  9. "I Have a Dream, Too!": The American Dream in Coretta Scott King Award-Winning Books

    Science.gov (United States)

    Parsons, Linda T.; Castleman, Michele

    2011-01-01

    The Coretta Scott King (CSK) Award, instituted in 1969 and recognized as an official award by the American Library Association (ALA) in 1982, is conferred annually to an African American author and an illustrator for their outstanding contributions to literature about the Black experience for children and young adults. A partial impetus for the…

  10. Two versions of solomon's prayer (1 kings 8 and 2 chronicles 6): a ...

    African Journals Online (AJOL)

    . We find this prayer in two different theological and literary traditions of the Bible: 1 Kings 8:22-53 and 2 Chronicles 6:12-42. In the light of these parallel versions one may pose the following questions: What are the similarities and differences ...

  11. The outcome of the first 1000 cases of LASIK performed at the king Hussein Medical Center

    Energy Technology Data Exchange (ETDEWEB)

    Abdallat, W [King Hussein Medical Centre, Amman (Jordan). Dept. of Ophthalmology

    2011-07-01

    The current study evaluates the refractive and visual outcome of patients who had laser in situ keratomileusis (LASIK) performed at the refractive center at King Hussein Medical centre in Jordan. The predictability of LASIK surgery in terms of refractive and visual outcome results is very good with mild regression in refraction over time. (author).

  12. The outcome of the first 1000 cases of LASIK performed at the king Hussein Medical Center

    International Nuclear Information System (INIS)

    Abdallat, W

    2011-01-01

    The current study evaluates the refractive and visual outcome of patients who had laser in situ keratomileusis (LASIK) performed at the refractive center at King Hussein Medical centre in Jordan. The predictability of LASIK surgery in terms of refractive and visual outcome results is very good with mild regression in refraction over time. (author).

  13. Density variation of 137Cs activity in surface soil from the King George Island

    International Nuclear Information System (INIS)

    Osores, Jose; Gonzales, Susana

    2013-01-01

    The behavior of radiocaesium from the nuclear tests conducted in the southern hemisphere was evaluated and their behavior was estimated on the floor of King George Island. Based on the findings made by several authors, the time of semi-exhaustion for Cs-137 was estimated at 4.5 years accumulated in the region since 1993. (authors).

  14. The King and Prisoner Puzzle: A Way of Introducing the Components of Logical Structures

    Science.gov (United States)

    Roh, Kyeong Hah; Lee, Yong Hah; Tanner, Austin

    2016-01-01

    The purpose of this paper is to provide issues related to student understanding of logical components that arise when solving word problems. We designed a logic problem called the King and Prisoner Puzzle--a linguistically simple, yet logically challenging problem. In this paper, we describe various student solutions to the puzzle and discuss the…

  15. Hazardous Waste Cleanup: Thermo King de Puerto Rico Incorporated in Arecibo, Puerto Rico

    Science.gov (United States)

    Thermo King de Puerto Rico, Inc. facility is located in the Zeno Gandia Industrial Area in Arecibo, Puerto Rico. Major features of the facility include six buildings used for manufacturing and storage, a wastewater treatment plant, a hazardous waste and no

  16. Metabolic response to lipid infusion in fasting winter-acclimatized king penguin chicks (Aptenodytes patagonicus).

    Science.gov (United States)

    Teulier, Loïc; Tornos, Jérémy; Rouanet, Jean-Louis; Rey, Benjamin; Roussel, Damien

    2013-05-01

    During the cold austral winter, king penguin chicks are infrequently fed by their parents and thus experience severe nutritional deprivation under harsh environmental conditions. These energetic constraints lead to a range of energy sparing mechanisms balanced by the maintenance of efficient thermogenic processes. The present work investigated whether the high thermogenic capacities exhibited by winter-acclimatized king penguin chicks could be related to an increase in lipid substrate supply and oxidation in skeletal muscle, the main site of thermogenesis in birds. To test this hypothesis, we examined i) the effect of an experimental rise in plasma triglyceride on the whole metabolic rate in winter-acclimatized (WA) and de-acclimatized king penguin chicks kept at thermoneutrality (TN), and ii) investigated the fuel preference of muscle mitochondria. In vivo, a perfusion of a lipid emulsion induced a small 10% increase of metabolic rate in WA chicks but not in TN group. In vitro, the oxidation rate of muscle mitochondria respiring on lipid-derived substrate was +40% higher in WA chicks than in TN, while no differences were found between groups when mitochondria oxidized carbohydrate-derived substrate or succinate. Despite an enhanced fuel selection towards lipid oxidation in skeletal muscle, a rise of circulating lipids per se was not sufficient to fully unravel the thermogenic capacity of winter-acclimatized king penguin chicks. Copyright © 2013 Elsevier Inc. All rights reserved.

  17. Examples of Mechanism Design : From King Solomon to eBay

    NARCIS (Netherlands)

    De Weerdt, M.M.

    2007-01-01

    The judgment of king Solomon is an early example of mechanism design. Mechanism design attempts to achieve desired outcomes in situations with self-interested players by setting the rules of the game in a specific way. We will see that the game Solomon proposed would not have worked if the women

  18. Conservative nutrient use by big-leaf mahogany (Swietenia macrophylla King) planted under contrasting environmental conditions

    Science.gov (United States)

    E. Medina; E. Cuevas; A.E. Lugo; E. Terezo; J. Jimenez-Osornio; P.A. Macario-Mendoza; P. Montanez

    2014-01-01

    We analyzed the nutritional composition and isotope ratios (C and N) of big-leaf mahogany (Swietenia macrophylla King) leaves in plantations established on contrasting soils and climates in Central America (State of Quintana Roo, Yucatan, Mexico) and South America (State of Para, Brazil). The objective was to determine the adaptability of this species to large...

  19. Carbon and nutrient contents in soils from the Kings River Experimental Watersheds, Sierra Nevada Mountains, California

    Science.gov (United States)

    D.W. Johnson; C.T. Hunsaker; D.W. Glass; B.M. Rau; B.A. Roath

    2011-01-01

    Soil C and nutrient contents were estimated for eight watersheds in two sites (one high elevation, Bull, and one low elevation, Providence) in the Kings River Experimental Watersheds in the western Sierra Nevada Mountains of California. Eighty-seven quantitative pits were dug to measure soil bulk density and total rock content, while three replicate surface samples...

  20. Transmedia Narrative in the Era of the Social mobbile. Carlos, King Emperor

    Directory of Open Access Journals (Sweden)

    José L. CARREÑO VILLADA

    2016-06-01

    Full Text Available Transmedia narratives are an integral part of mobile communication and are becoming one of the most recurrent when presenting a new audiovisual format forms. Carlos, King Emperor series makes use of transmedia storytelling to reach the user and interact with it through the different elements of your macro narrative universe, elements such as video game or profiles on social networks.

  1. Aspects of the biology of three benthic-feeding teleosts from King's ...

    African Journals Online (AJOL)

    Aspects of the biology of three benthic-feeding teleosts from King's Beach, Algoa Bay. Theresa A. Lasiak. Department of Zoology, University of Port Elizabeth, Port Elizabeth. The lengths, abundance pattems and feeding habits of three species of benthic·feeding teleosts, Lithognathus mormyrus,. Lithognathus lithognathus ...

  2. Siim Nestor soovitab : Goldie. Kevin Saunderson. Nicole Willis. King Britt / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2005-01-01

    Popmuusikaüritustest: briti muusik Goldie esineb jungle-muusikaga Tallinnas 21. apr. klubis Privé, DJ Kevin Saunderson 22. apr. klubis Privé, laulja Nicole Willis 27. apr. BonBon Jazz Lounge'il klubis BonBon, Philadelphia muusik King Britt ja Eesti ansambel Broken Time Orchestra esitlevad oma heliplaate

  3. The Poukai ceremony of the Maori King Movement: An ethnohistorical interpretation

    NARCIS (Netherlands)

    Meijl, A.H.M. van

    2009-01-01

    The poukai is a ceremonial gathering held on 28 days a year at different Marae [1] or ceremonial centres supporting the K ngitanga, or Maori King Movement, which is largely based within the Tainui confederation of tribes in the Waikato region of New Zealand's North Island. The K ngitanga was

  4. Wole Soyinka's A Play of Giants and King Baabu : The crises ...

    African Journals Online (AJOL)

    This paper, using Soyinka's A Play of Giants and King Baabu, re-examines the centrality of ideology to texts of social engagement in the postcolonial space. Within the context of the humanistic values that the playwright esteems, this essay scrutinizes the social conditions in the plays and the dramatist's “vision.

  5. Africa in the imaginary: the geographical explorations of the king Juba II of Mauretania

    Directory of Open Access Journals (Sweden)

    Enrique GOZALBES CRAVIOTO

    2012-03-01

    Full Text Available In the present study we analyzed the different texts of the Latin encyclopaedist Plinio, specially the texts that refer to the geographical explorations of the king Juba II of Mauretania. These explorations developed from two directions, the Atlantic Africa and the mountain chain of the Atlas. Juba II contemplated both cases from the own image inherited from the African continent.

  6. Utilidade e significância social da teoria do alcance de metas de king

    Directory of Open Access Journals (Sweden)

    Inácia Sátiro Xavier de França

    2002-02-01

    Full Text Available Esta pesquisa enfocou o modelo de análise de teorias de Meleis, a Teoria do Alcance de Objetivos (King, 1981 e um estudo realizado por Silveira, objetivando analisar a utilidade e significância social da Teoria de King. Realizamos uma leitura compreensiva da Teoria de King e do modelo proposto por Meleis. Recortamos, desse modelo, o segmento "Crítica de teoria" para servir de suporte analítico. Selecionamos o estudo "Estar despido na unidade de terapia intensiva: duas percepções e um encontro" (Silveira, 1996, cujo marco teórico é a teoria supracitada. Da análise crítica, apoiada na inter-relação desses construtos, concluímos que: a teoria de King é útil à pesquisa por possibilitar a percepção e a interpretação dos dados objetivo-subjetivos da realidade concreta. Sua significância social tem relação com a aplicação da teoria por representantes dos vários segmentos sociais, viabilizando a re-socialização de pessoas e grupos em prol de um mundo mais humano, solidário, cidadão.

  7. 77 FR 22606 - Proposed Information Collection; Visitor Use Surveys for Headwaters Forest Reserve and King Range...

    Science.gov (United States)

    2012-04-16

    ... visitor use surveys would assist the BLM in meeting goals set forth in Resource Management Plans (RMPs... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLCAN03900 L17110000 AL0000] Proposed Information Collection; Visitor Use Surveys for Headwaters Forest Reserve and King Range National Conservation...

  8. RISK MANAGEMENT DISCLOSURE PRACTICESIN ACCORDANCEWITH KING II AND III: THE CASE OF SELECTED JSE LISTEDCOMPANIES

    Directory of Open Access Journals (Sweden)

    Heleen Janse van Vuuren

    2016-07-01

    Full Text Available The ongoing collapse of large international companies could have been partiallyprevented if good corporate governance principles and,more specifically,effectiverisk management practices had been implemented and adhered to.Research reveals that the majority offinancial institutions in Europe do notmanage risk effectively and the global financial crisis proved that excessive risk-taking can result in corporate failure. Similar trends are prevalent in South Africa.The aim of this research was to investigate the compliance of Johannesburg StockExchange (JSE listed companies with recommended risk management practicesand disclosure requirements after the introduction of King II and III. To achievethis the annual reports ofselectedJSElisted companies were evaluated toestablish the quality of their reporting on risk management practices asrecommended in King II andIII. The results of the study indicated that theminority of the companies investigated, fully complied with all the recommendedrequirements. This study contributed to literature by showing that althoughdisclosure on risk management practicesimproved significantly since King IIbecame operational in 2002, companies still did not adhere to all the requirementsas stipulated even after King III became effectivein 2010. The finding, therefore,supports the notion that full compliance is an evolutionary process, rather than arevolutionary process and will therefore only be achieved over time.

  9. Critical Discourse Analysis of Martin Luther King's Speech in Socio-Political Perspective

    Science.gov (United States)

    Sipra, Muhammad Aslam; Rashid, Athar

    2013-01-01

    The article presents the Critical Discourse Analysis (CDA) of the first part of King Martin Luther's speech "When I Have a Dream" in socio-political context. The study investigates how it lies on the basis of application of Fairclough version of CDA in the first part of the text. Moreover, it explicates the terms like social, cultural…

  10. Martin Luther King, Jr.: A Lesson with Interdisciplinary Connections for Middle-Level Music Students.

    Science.gov (United States)

    Early, Mary Frances; Terry, Cynthia

    This lesson begins with a very brief biography of Martin Luther King, Jr. The lesson identifies its educational objectives; addresses National Standards for Music Education; lists materials needed; details six step-by-step classroom procedures for lesson implementation; and provides curriculum connections for language arts, visual art, physical…

  11. The Kings River Sustainable Forest Ecosystems Project: inception, objectives, and progress

    Science.gov (United States)

    Jared Verner; Mark T. Smith

    2002-01-01

    The Kings River Sustainable Forest Ecosystems Project, a formal administrative study involving extensive and intensive collaboration between Forest Service managers and researchers, is a response to changes in the agency’s orientation in favor of ecosystem approaches and to recent concern over issues associated with maintenance of late successional forest attributes...

  12. 77 FR 38005 - Safety Zone; Independence Day Fireworks, Kings Beach, CA

    Science.gov (United States)

    2012-06-26

    ... Zone; Independence Day Fireworks, Kings Beach, CA AGENCY: Coast Guard, DHS. ACTION: Notice of... Independence Day Fireworks display from 7 a.m. until 10 p.m. on July 3, 2012. This action is necessary to protect life and property of the maritime public from the hazards associated with the fireworks display...

  13. Symmetry breaking in Landau gauge. A comment to a paper by T. Kennedy and C. King

    International Nuclear Information System (INIS)

    Borgs, C.; Nill, F.

    1986-01-01

    The authors generalize the result of T. Kennedy and C. King (Princeton preprint, 1985) on the non-compact abelian lattice Higgs model in Landau gauge in order to show that there are states parameterized by an angle such that the expectation value of the Higgs field is described by a phase factor and a value which is uniformly bounded away from zero. (HSI)

  14. Phreatic explosions during basaltic fissure eruptions: Kings Bowl lava field, Snake River Plain, USA

    Science.gov (United States)

    Hughes, Scott S.; Kobs Nawotniak, Shannon E.; Sears, Derek W. G.; Borg, Christian; Garry, William Brent; Christiansen, Eric H.; Haberle, Christopher W.; Lim, Darlene S. S.; Heldmann, Jennifer L.

    2018-02-01

    Physical and compositional measurements are made at the 7 km-long ( 2200 years B.P.) Kings Bowl basaltic fissure system and surrounding lava field in order to further understand the interaction of fissure-fed lavas with phreatic explosive events. These assessments are intended to elucidate the cause and potential for hazards associated with phreatic phases that occur during basaltic fissure eruptions. In the present paper we focus on a general understanding of the geological history of the site. We utilize geospatial analysis of lava surfaces, lithologic and geochemical signatures of lava flows and explosively ejected blocks, and surveys via ground observation and remote sensing. Lithologic and geochemical signatures readily distinguish between Kings Bowl and underlying pre-Kings Bowl lava flows, both of which comprise phreatic ejecta from the Kings Bowl fissure. These basalt types, as well as neighboring lava flows from the contemporaneous Wapi lava field and the older Inferno Chasm vent and outflow channel, fall compositionally within the framework of eastern Snake River Plain olivine tholeiites. Total volume of lava in the Kings Bowl field is estimated to be 0.0125 km3, compared to a previous estimate of 0.005 km3. The main (central) lava lake lost a total of 0.0018 km3 of magma by either drain-back into the fissure system or breakout flows from breached levees. Phreatic explosions along the Kings Bowl fissure system occurred after magma supply was cut off, leading to fissure evacuation, and were triggered by magma withdrawal. The fissure system produced multiple phreatic explosions and the main pit is accompanied by others that occur as subordinate pits and linear blast corridors along the fissure. The drop in magma supply and the concomitant influx of groundwater were necessary processes that led to the formation of Kings Bowl and other pits along the fissure. A conceptual model is presented that has relevance to the broader range of low-volume, monogenetic

  15. Biohistorical materials and contemporary privacy concerns-the forensic case of King Albert I.

    Science.gov (United States)

    Larmuseau, Maarten H D; Bekaert, Bram; Baumers, Maarten; Wenseleers, Tom; Deforce, Dieter; Borry, Pascal; Decorte, Ronny

    2016-09-01

    The rapid advancement of technology in genomic analysis increasingly allows researchers to study human biohistorical materials. Nevertheless, little attention has been paid to the privacy of the donor's living relatives and the negative impact they might experience from the (public) availability of genetic results, even in cases of scientific, forensic or historical relevance. This issue has become clear during a cold case investigation of a relic attributed to Belgian King and World War I-hero Albert I who died, according to the official version, in a solo climbing accident in 1934. Authentication of the relic with blood stains assigned to the King and collected on the place where his body was discovered is recognised as one of the final opportunities to test the plausibility of various conspiracy theories on the King's demise. While the historical value and current technological developments allow the genomic analysis of this relic, publication of genetic data would immediately lead to privacy concerns for living descendants and relatives of the King, including the Belgian and British royal families, even after more than 80 years. Therefore, the authentication study of the relic of King Albert I has been a difficult exercise towards balancing public research interests and privacy interests. The identification of the relic was realised by using a strict genetic genealogical approach including Y-chromosome and mitochondrial genome comparison with living relatives, thereby limiting the analysis to genomic regions relevant for identification. The genetic results combined with all available historical elements concerning the relic, provide strong evidence that King Albert I was indeed the donor of the blood stains, which is in line with the official climbing accident hypothesis and contradicts widespread 'mise-en-scène' scenarios. Since publication of the haploid data of the blood stains has the potential to violate the privacy of living relatives, we opted for

  16. Extreme Precipitation, Stormwater, and Flooding in King County: Co-producing Research to Support Adaptation

    Science.gov (United States)

    Mauger, G. S.; Lorente-Plazas, R.; Salathe, E. P., Jr.; Mitchell, T. P.; Simmonds, J.; Lee, S. Y.; Hegewisch, K.; Warner, M.; Won, J.

    2017-12-01

    King County has experienced 12 federally declared flood disasters since 1990, and tens of thousands of county residents commute through, live, and work in floodplains. In addition to flooding, stormwater is a critical management challenge, exacerbated by aging infrastructure, combined sewer and drainage systems, and continued development. Even absent the effects of climate change these are challenging management issues. Recent studies clearly point to an increase in precipitation extremes for the Pacific Northwest (e.g., Warner et al. 2015). Yet very little information is available on the magnitude and spatial distribution of this change. Others clearly show that local-scale changes in extreme precipitation can only be accurately quantified with dynamical downscaling, i.e.: using a regional climate model. This talk will describe a suite of research and adaptation efforts developed in a close collaboration between King County and the UW Climate Impacts Group. Building on past collaborations, research efforts were defined in collaboration with King County managers, addressing three key science questions: (1) How are the mesoscale variations in extreme precipitation modulated by changes in large-scale weather conditions? (2) How will precipitation extremes change? This was assessed via two new high-resolution regional model projections using the Weather Research and Forecasting (WRF) mesoscale model (Skamarock et al. 2005). (3) What are the implications for stormwater and flooding in King County? This was assessed by both exploring the statistics of hourly precipitation extremes in the new projections, as well as new hydrologic modeling to assess the implications for river flooding. The talk will present results from these efforts, review the implications for King County planning and infrastructure, and synthesize lessons learned and opportunities for additional work.

  17. Interactions between surface waters in King George Island, Antarctica - a stable isotope perspective

    Science.gov (United States)

    Perşoiu, Aurel; Bădăluşă, Carmen

    2017-04-01

    In this paper we present a first study of the isotopic composition of surface waters in the southern peninsulas (Barton, Fildes, Weaver and Potter) of King George Island, Antarctica. We have collected > 200 samples of snow and snowmelt, water (lake, river and spring), ice (glacier ice and permafrost) from the four peninsulas in February 2016 and analyzed them for their oxygen and hydrogen stable isotopic composition. Samples from lake water (50+) indicate a clear west-east depletion trend, suggesting a rain-out process as air masses are moving westward (and are progressively depleted in heavy isotopes) from their origin in the Drake Passage. In both Fildes and Barton Peninsulas, permafrost samples have the heaviest isotopic composition, most probably due to preferential incorporation of heavy isotopes in the ice during freezing (and no fractionation during melting). As permafrost melts, the resulting water mixes with isotopically lighter infiltrated snowmelt, and thus the groundwater has a lower isotopic composition. Further, lake and river (the later fed by lakes) water has the lightest isotopic composition, being derived mostly from the melting of light snow and glacier ice. It seems feasible to separate isotopically water in lakes/rivers (largely fed by melting multi-year glaciers and snow) and water from melting of snow/ground ice This preliminary study suggests that it is possible to separate various water sources in the southern peninsulas of King George Island, and this separation could be used to study permafrost degradation, as well as feeding and migration patterns in the bird fauna, with implications for protection purposes. Acknowledgments. The National Institute of Research and Development for Biological Sciences (Bucharest, Romania) and the Korean polar institute financially supported fieldwork in King George Island. We thank the personal at King Sejong (South Korea), Belingshaussen (Russia) and Carlini (Argentina) stations in King George Island for

  18. [Vectorial transmission of malaria in a village along the Niger River and its fishing hamlet (Kéniéroba and Fourda, Mali)].

    Science.gov (United States)

    Keïta, M; Baber, I; Sogoba, N; Maïga, H M; Diallo, M'b; Doumbia, S; Traoré, S F

    2014-12-01

    A better understanding of malaria transmission dynamics is an essential element in the development of any targeted vector control strategy. The objective of this study was to better understand malaria transmission dynamics along the Niger River in Sudan savanna zone of Mali. Trough cross-sectional surveys, Anopheline larvae were collected by WHO standard dipping technique, and vector adults by Human Landing and pyrethrum spray catches methods. The vector population was composed of An. gambiae s.l. (> 99%) and An. funestus (hamlet Fourda) compared to farther inland Kéniéroba. The average infection rate of An. gambiae s.l. was 3.63% and 4.06% in Kéniéroba and Fourda respectively. The average entomological inoculation rate (EIR) during the study period was almost similar in Kéniéroba (0.70 infective bites/person/month) and Fourda (0.69 infective bites/person/month). The means EIRs over each of the rainy season 2006 and 2007 were always higher than the one of the dry season 2007 in both localities, with much smaller amplitude in Fourda than in Kéniéroba. However, the level of the transmission was 2.31 (0.37/0.16) times higher in Fourda than in Kéniéroba during the dry season.We conclude that in Sudan savanna zone of Mali, malaria transmission along the river is continuous throughout the year, but it is more intense in the immediate vicinity of the river during the dry season than during the rainy season in opposition to more distant localities to the river and vector control should not be focused only on the rainy in such setting.

  19. An analysis of Cobit 5 as a framework for the implementation of it governance with reference to King III

    Directory of Open Access Journals (Sweden)

    Maseko, L.

    2016-02-01

    Full Text Available Owing to the complexity and general lack of understanding of information technology (“IT”, the management of IT is often treated as a separately managed value-providing asset. This has resulted in IT rarely receiving the necessary attention of the board, thus creating a disconnect between the board and IT. The King Code of Governance for South Africa 2009 (hereafter referred to as “King III” provides principles and recommended practices for effective IT governance in order to create a greater awareness at board level. King III, however, provides no detailed guidance with regard to the practical implementation of these principles and practices. It is worth noting that numerous international guidelines are recommended within King III that can be adopted as frameworks to assist in the effective implementation of IT governance. COBIT 5 provides, as part of its governance process practices, related guidance activities linking it to the seven IT governance principles of King III, thus making it a practical framework for the implementation of King III recommendations. This study sought to establish the extent to which the governance processes, practices and activities of COBIT 5 are mapped to the recommended practices of IT governance as highlighted in King III in order to resolve COBIT 5 as the de facto framework for IT governance in terms of King III. The study found that though King III principles and practices may be interpreted as vague with regard to how to implement IT governance principles, COBIT 5 succeeds in bridging the gap between control requirements, technical issues, information systems and business risk, which consequently results in a better facilitation of IT governance. The study also revealed that COBIT 5 contains additional activities to assist the board in more transparent reporting of IT performance and conformance management to stakeholders as well activities which enable the connection of resource management with human

  20. A adaptação como procedimento técnico de tradução: uma leitura descritiva do Hamlet em quadrinhos brasileiro Adaptation as a technical procedure of translation: a descriptive reading of Hamlet in a Brazilian comic book

    Directory of Open Access Journals (Sweden)

    Marcel Alvaro de Amorim

    2013-03-01

    Full Text Available Os procedimentos técnicos da tradução foram identificados pela primeira vez no trabalho de Vinay e Darbelnet ([1958] 1977. Dentre esses procedimentos, o da adaptação foi então descrito, de forma local, como a adequação cultural ou situacional do texto da língua de partida no texto da língua de chegada. Na atualidade, mais que um procedimento local, teóricos como Bastin ([1998] 2011 consideram a prática da adaptação como um procedimento global, que envolve diversos outros procedimentos secundários de tradução. Sendo assim, os objetivos principais deste trabalho foram sistematizar uma categorização dos procedimentos secundários do processo de adaptação e aplicar tal categorização à análise de uma tradução/adaptação da peça Hamlet, de William Shakespeare, para o português brasileiro realizada por Bruno S. R. e ilustrada por Sam Hart, cotejando a com outras traduções estabelecidas da peça sempre que necessário.The technical procedures of translation were first identified in the work of Vinay and Darbelnet ([1958] 1977. Among these procedures, the adaptation was described, locally, as cultural or situational adequacy of the source text in the target culture and language. Currently, more than a local procedure, researchers as Bastin ([1998] 2011 have been considering adaptation as a global one that involves several other secondary procedures in the translation process. Therefore, the main objectives of this study were to categorize the secondary procedures of the adaptation process and apply this categorization to the analysis of a translation/adaptation of the play Hamlet, by William Shakespeare, written by Bruno S. R. and illustrated by Sam Hart, comparing it with other traditional translations of the play whenever necessary.