Geochemical models of the precipitation of halite (NaCl) in gas fields

International Nuclear Information System (INIS)

Lombana O, Jose L; Jaramillo, Elizabeth A; Alzate E, Guillermo A

2005-01-01

The reservoir modeling is a tool that every day takes more importance in the petroleum industry due to multiple problems presented an also that can be afforded by it during the production of reservoir fluids from the porous media in petroleum reservoir. One of these is the formation damage which is reflected as a petrophysic properties change, caused among other factors by the scale precipitation of halite (NaCl) as a consequence of the original state alteration and thermodynamic balance disruption between the porous media and the fluids inside by the gas flow. By the gas flow over the connate water, the porous media reduce its water saturation due to water transferring from liquid to gas state. In this study, a numeric model is developed to model the formation damage for halite precipitation. The model covers one-dimensional monophasic and iso thermic gas flow and evaluates the porosity and permeability changes of porous media due to halite precipitation. The model application for different conditions of temperature, connate water salinity, water saturation,and porosity indicates the following: the biggest damage is caused to the beginning of the porous media,temperature influences considerably the water vaporization rate and therefore the amount of halite precipitation, the lower the porosity of the porous media the bigger the formation damage degree, and finally, higher salinity and water saturation for the connate water in the porous media higher the formation damage degree is reached by the gas flow.

Structural petrology of undeformed and experimentally deformed halite samples from USERDA site No. 7 and No. 9

International Nuclear Information System (INIS)

Callender, J.; Ingwell, T.

1977-01-01

Preliminary data from USERDA test holes No. 7 and No. 9 in the Salado Formation of southeastern New Mexico are presented. Cores consist primarily of halite (> 80 modal percent), clay, polyhalite, anhydrite, celestite, iron oxide, and magnesite. Macroscopic features of undeformed core include moderately tight grain boundaries, large cavities (less than or equal to 8 mm 2 ), fluid inclusions, rare intragranular dislocations, and coarse and bimodal textures. Petrographic examination reveals numerous secondary fluid inclusions of variable size, blebby halite and transected hopper crystals, all of which suggest mobility and recrystallization of the primary evaporite assemblages. Deformed core shows a complex group of fabric elements, including tight grain boundaries, intercrystalline lattice rotation, cavity deformation and closure, distortion of hopper crystals, polygonization, irregular lattice dislocations, glide dislocations, and climb dislocations. Grain boundaries become tight or locked with deformation, forming pinned and bulged grains. Intercrystalline lattice rotation causes grains to rotate as much as 17 0 to develop preferred orientation. Polygonization yields fabrics analogous to prophyroclasts in cataclastic rocks. Irregular dislocations are relatively abundant. Glide dislocations are also abundant in many deformed specimens. Individual mineral components within deformed halite also exhibit deformational fabrics. Folded layers of clay and anhydrite, and bent and broken single crystals of anhydrite are present in some samples. Secondary fluid inclusions apparently migrate in response to differential stress and form along dislocations in halite, healing the dislocations by secondary crystallization and forming discontinuous or completely healed dislocation fabrics. 67 figures, 9 tables

The salt that wasn't there: Mudflat facies equivalents to halite of the Permian Rustler Formation, southeastern New Mexico

International Nuclear Information System (INIS)

Powers, D.W.; Holt, R.M.

2000-01-01

Four halite beds of the Permian Restler Formation in southeastern New Mexico thin dramatically over horst lateral distances to correlative classic (mudstone) beds. The mudstones have long been considered residues after post-burial dissolution (subrosion) of halite, assumed to have been deposited continuously across the area. Hydraulic properties of the Culebra Dolomite Member have often been related to Rustler subrosion. In cores and three shafts at the Waste Isolation Pilot Plant (WIPP), however, these mudstones display flat bedding, graded bedding, cross-bedding, erosional contacts, and channels filled with intraformational conglomerates. Cutans indicate early stages of soil development during subaerial exposure. Smeared intraclasts developed locally as halite was removed syndepositionally during subaerial exposure. The authors interpret these beds as facies formed in salt-pan or hypersaline-lagoon, transitional, and mudflat environments. Halite is distributed approximately as it was deposited. Breccia in limited areas along one halite margin indicates post-burial dissolution, and these breccials are key to identifying areas of subrosion. A depositional model accounts for observed sedimentary features of Restler mudstones. Marked facies and thickness changes are consistent with influence by subsidence boundaries, as found in some modern continental evaporites. A subrosion model accounts for limited brecciated zones along (depositional)halite margins, but bedding observed in the mudstones would not survive 90% reduction in rock volume. Depositional margins for these halite beds will be useful in reconstructing detailed subsidence history of the Late Permian in the northern Delaware Basin, It also no longer is tenable to attribute large variations in Culebra transmissivity to Rustler subrosion

Status Report on the Microbial Characterization of Halite and Groundwater Samples from the WIPP

International Nuclear Information System (INIS)

Swanson, Juliet S.; Reed, Donald T.; Ams, David A.; Norden, Diana; Simmons, Karen A.

2012-01-01

This report summarizes the progress made in the ongoing task of characterizing the microbial community structures within the WIPP repository and in surrounding groundwaters. Through cultivation and DNA-based identification, the potential activity of these organisms is being inferred, thus leading to a better understanding of their impact on WIPP performance. Members of the three biological domains - Bacteria, Archaea, and Eukarya (in this case, Fungi) - that are associated with WIPP halite have been identified. Thus far, their activity has been limited to aerobic respiration; anaerobic incubations are underway. WIPP halite constitutes the near-field microbial environment. We expect that microbial activity in this setting will proceed from aerobic respiration, through nitrate reduction to focus on sulfate reduction. This is also the current WIPP performance assessment (PA) position. Sulfate reduction can occur at extremely high ionic strengths, and sulfate is available in WIPP brines and in the anhydrite interbeds. The role of methanogenesis in the WIPP remains unclear, due to both energetic constraints imposed by a high-salt environment and substrate selectivity, and it is no longer considered in PA. Archaea identified in WIPP halite thus far fall exclusively within the family Halobacteriaceae. These include Halobacterium noricense, cultivated from both low- and high-salt media, and a Halorubrum-like species. The former has also been detected in other salt mines worldwide; the latter likely constitutes a new species. Little is known of its function, but it was prevalent in experiments investigating the biodegradation of organic complexing agents in WIPP brines. Bacterial signatures associated with WIPP halite include members of the phylum Proteobacteria - Halomonas, Pelomonas, Limnobacter, and Chromohalobacter - but only the latter has been isolated. Also detected and cultivated were Salinicoccus and Nesterenkonia spp. Fungi were also isolated from halite. Although

Status Report on the Microbial Characterization of Halite and Groundwater Samples from the WIPP

Energy Technology Data Exchange (ETDEWEB)

Swanson, Juliet S. [Los Alamos National Laboratory; Reed, Donald T. [Los Alamos National Laboratory; Ams, David A. [Los Alamos National Laboratory; Norden, Diana [Ohio State University; Simmons, Karen A. [Los Alamos National Laboratory

2012-07-10

This report summarizes the progress made in the ongoing task of characterizing the microbial community structures within the WIPP repository and in surrounding groundwaters. Through cultivation and DNA-based identification, the potential activity of these organisms is being inferred, thus leading to a better understanding of their impact on WIPP performance. Members of the three biological domains - Bacteria, Archaea, and Eukarya (in this case, Fungi) - that are associated with WIPP halite have been identified. Thus far, their activity has been limited to aerobic respiration; anaerobic incubations are underway. WIPP halite constitutes the near-field microbial environment. We expect that microbial activity in this setting will proceed from aerobic respiration, through nitrate reduction to focus on sulfate reduction. This is also the current WIPP performance assessment (PA) position. Sulfate reduction can occur at extremely high ionic strengths, and sulfate is available in WIPP brines and in the anhydrite interbeds. The role of methanogenesis in the WIPP remains unclear, due to both energetic constraints imposed by a high-salt environment and substrate selectivity, and it is no longer considered in PA. Archaea identified in WIPP halite thus far fall exclusively within the family Halobacteriaceae. These include Halobacterium noricense, cultivated from both low- and high-salt media, and a Halorubrum-like species. The former has also been detected in other salt mines worldwide; the latter likely constitutes a new species. Little is known of its function, but it was prevalent in experiments investigating the biodegradation of organic complexing agents in WIPP brines. Bacterial signatures associated with WIPP halite include members of the phylum Proteobacteria - Halomonas, Pelomonas, Limnobacter, and Chromohalobacter - but only the latter has been isolated. Also detected and cultivated were Salinicoccus and Nesterenkonia spp. Fungi were also isolated from halite. Although

Interpreting irregularity in small-scale, cyclical precipitation of halite-anhydrite couplets within the Pennsylvanian Paradox Formation, Paradox Basin, Utah

Science.gov (United States)

Marra, K. R.; Agena, W. F.; Dubiel, R. F.; Lee, M. W.; Pitman, J. K.

2012-12-01

The Pennsylvanian Paradox Formation (Hermosa Group) contains 33 documented evaporite cycles consisting of thick (6-240 m) halite successions interbedded with anhydrite, silty dolomite, and black shale. The evaporite deposits precipitated from marine brines under restricted circulation conditions in the Paradox Basin, a northwest-southeast trending asymmetrical trough formed adjacent to the Uncompahgre uplift, where periodic glacioeustatic sea-level fluctuations and intermittent meteoric water influxes altered salinity gradients. Each salt cycle contains rhythmically bedded halite-anhydrite couplets, in which anhedral to euhedral bottom-growth halite crystals are overlain by thin (mm-scale), subaqueously precipitated layers of anhydrite in the form of "snow-on-the-roof" texture. Discrete grains of sylvite, which are red due to hematite inclusions, locally occur as bands or aggregates throughout most salt packages. In order to delineate controls on high-frequency halite-anhydrite precipitation, the thickness of distinct couplets were measured in four salt cycles, two (Cycles 3 and 5) in the Cane Creek No.1 corehole and two (Cycles 5 and 13) in the Shafer No. 1 corehole. The cores were drilled approximately 8 km apart within the central portion of the basin near the crests of the Cane Creek and Shafer salt anticlines. The thickness of halite-anhydrite couplets ranges between 1-90 cm for all measured cycles, with the most commonly occurring thickness of approximately 3-4 cm. Despite the proximity of the two cores, the salt cycles in the Shafer No. 1 core are 12-15m thicker than in the Cane Creek No. 1 core, and individual couplets thicken within the middle (~20 m) of the salt section. In contrast, couplets thicken near the top of the halite bed in the Cane Creek No.1 core, which is most pronounced in Cycle 5. Locally disrupted and distorted laminae due to salt flowage, however, complicates some laminae measurements. The small-scale, cyclical pattern of halite

Decoration of dislocations by proton irradiation of halite

International Nuclear Information System (INIS)

Bird, J.R.; Rose, A.; Wilkins, R.W.T.

1981-01-01

Proton irradiation of halite (NaCl) at temperatures in the range 150-220 0 C produces a variety of colours from yellow/brown through blue to violet/red. Under suitable conditions, colour bands are formed which decorate dislocations and colour other crystal features. One beam line of the Lucas Heights 3 MV Van de Graaff accelerator has been adapted to permit the measurement of optical absorption spectra during proton irradiation of heated crystals. The results show that colour centre formation is a more complex process than has been previously reported, even for synthetic NaCl crystals. The dependence of absorption at various wavelengths on dose, dose rate, temperature, strain and exposure to light is being used to study the different quasi-equilibrium concentrations of colour centres involved in the decoration process. Proton induced X-ray measurements provide information on the presence of impurities which can have an important influence on colour centre formation. (orig.)

Radiation damage in natural and synthetic halite. Progress report January 1992 - February 1993

International Nuclear Information System (INIS)

Garcia Celma, A.

1993-12-01

This report complements the information presented in the report of December 1992 regarding the research performed at the ECN on radiation damage in salt. It consists of two parts. The first part regards the amount of stored energy which can be developed by gamma-irradiation on different types of halite and considers both the effect of low dose rates in developing radiation damage, and the possible saturation level of radiation damage in natural halite. The second part presents a model to simulate radiation damage development which incorporates some extensions in the Jain-Lidiard model. Due to malfunction of the Small Angle Neutron Scattering installation, neither the previously reported results nor the newly obtained can be trusted and therefore are not reported here. These results regard the shape, size and size distribution of radiation damage defects. (orig.)

Biomimetic Coating on Porous Alumina for Tissue Engineering: Characterisation by Cell Culture and Confocal Microscopy

Directory of Open Access Journals (Sweden)

Elizabeth Kolos

2015-06-01

Full Text Available In this study porous alumina samples were prepared and then coated using the biomimetic coating technique using a five times Simulated Body Fluid (5.0SBF as the growth solution. A coating was achieved after pre-treatment with concentrated acid. From elemental analysis, the coating contained calcium and phosphorous, but also sodium and chlorine. Halite was identified by XRD, a sodium chloride phase. Sintering was done to remove the halite phase. Once halite was burnt off, the calcium phosphate crystals were not covered with halite and, therefore, the apatite phases can be clearly observed. Cell culturing showed sufficient cell attachment to the less porous alumina, Sample B, that has more calcium phosphate growth, while the porous alumina, Sample A, with minimal calcium phosphate growth attained very little cell attachment. This is likely due to the contribution that calcium phosphate plays in the attachment of bone-like cells to a bioinert ceramic such as alumina. These results were repeated on both SEM and confocal microscopy analysis. Confocal microscopy was a novel characterisation approach which gave useful information and was a visual aid.

Salt precipitation and dissolution in the late Quaternary Dead Sea: Evidence from chemical and δ37Cl composition of pore fluids and halites

Science.gov (United States)

Levy, Elan J.; Yechieli, Yoseph; Gavrieli, Ittai; Lazar, Boaz; Kiro, Yael; Stein, Mordechai; Sivan, Orit

2018-04-01

The chemical composition and δ37Cl of pore fluids from the ICDP core drilled in the deepest floor of the terminal and hypersaline Dead Sea, and halites from the adjacent Mount Sedom salt diapir, are used to establish the dynamics of halite precipitation and dissolution during the last interglacial and glacial periods. Between ∼132 and 116 thousand years ago (ka) halites precipitated in the lake resulting in the expulsion of Na+ and Cl- from the residual solution. Over 50% of the Cl- reservoir was removed, resulting in a decrease in the Na/Cl ratio from 0.57 to 0.19. This process was accompanied by a decrease in δ37Cl values in the precipitating halites and the associated residual Cl- in the lake. The observed decrease fits a Rayleigh distillation curve with a fractionation factor of Δ(NaCl-Dead Sea solution) = +0.32‰ (±0.12) determined in the present study. This behavior implies negligible contribution of external sources of Cl- to the lake during the main peak of the last interglacial, MIS5e. Subsequently, during the last glacial (ca. 117 to 17 ka) dissolution of halite took place, the Na+ and Cl- inventory were replenished, accompanied by an increase in Na/Cl from 0.21 to 0.55 and in the δ37Cl values from -0.46‰ to -0.12‰. While the lake underwent significant dilution during that time, the decrease in salinity was somewhat suppressed by the dissolution of the halite which was mostly derived from Mount Sedom salt diapir.

Provision of water by halite deliquescence for Nostoc commune biofilms under Mars relevant surface conditions

Science.gov (United States)

Jänchen, Jochen; Feyh, Nina; Szewzyk, Ulrich; de Vera, Jean-Pierre P.

2016-04-01

Motivated by findings of new mineral related water sources for organisms under extremely dry conditions on Earth we studied in an interdisciplinary approach the water sorption behaviour of halite, soil component and terrestrial Nostoc commune biofilm under Mars relevant environmental conditions. Physicochemical methods served for the determination of water sorption equilibrium data and survival of heterotrophic bacteria in biofilm samples with different water contents was assured by recultivation. Deliquescence of halite provides liquid water at temperatures <273 K and may serve as water source on Mars during the morning stabilized by the CO2 atmosphere for a few hours. The protecting biofilm of N. commune is rather hygroscopic and tends to store water at lower humidity values. Survival tests showed that a large proportion of the Alphaproteobacteria dominated microbiota associated to N. commune is very desiccation tolerant and water uptake from saturated NaCl solutions (either by direct uptake of brine or adsorption of humidity) did not enhance recultivability in long-time desiccated samples. Still, a minor part can grow under highly saline conditions. However, the salinity level, although unfavourable for the host organism, might be for parts of the heterotrophic microbiota no serious hindrance for growing in salty Mars-like environments.

INTRAVAL Phase 2 WIPP 1 test case report: Modeling of brine flow through halite at the Waste Isolation Pilot Plant site

International Nuclear Information System (INIS)

Beauheim, R.L.

1997-05-01

This report describes the WIPP 1 test case studied as part of INTRAVAL, an international project to study validation of geosphere transport models. The WIPP 1 test case involved simulation of measured brine-inflow rates to boreholes drilled into the halite strata surrounding the Waste Isolation Pilot Plant repository. The goal of the test case was to evaluate the use of Darcy's law to describe brine flow through halite. The general approach taken was to try to obtain values of permeability and specific capacitance that would be: (1) consistent with other available data and (2) able to provide reasonable simulations of all of the brine-inflow experiments performed in the Salado Formation. All of the teams concluded that the average permeability of the halite strata penetrated by the holes was between approximately 10 -22 and 10 -21 m 2 . Specific capacitances greater than 10 -10 Pa -1 are inconsistent with the known constitutive properties of halite and are attributed to deformation, possibly ongoing, of the halite around the WIPP excavations. All project teams found that Darcy-flow models could replicate the experimental data in a consistent and reasonable manner. Discrepancies between the data and simulations are attributed to inadequate representation in the models of processes modifying the pore-pressure field in addition to the experiments themselves, such as ongoing deformation of the rock around the excavations. Therefore, the conclusion from the test case is that Darcy-flow models can reliably be used to predict brine flow to WIPP excavations, provided that the flow modeling is coupled with measurement and realistic modeling of the pore-pressure field around the excavations. This realistic modeling of the pore-pressure field would probably require coupling to a geomechanical model of the stress evolution around the repository

A newly isolated Haloalkaliphilic bacterium from middle-late Eocene halite formed in salt lakes in China

Czech Academy of Sciences Publication Activity Database

Meng, F. W.; Wang, X.-Q.; Ni, P.; Kletetschka, Günther; Li, Y-P.; Yang, Ch.-H.

2015-01-01

Roč. 30, č. 3 (2015), s. 321-330 ISSN 0891-2556 Institutional support: RVO:67985831 Keywords : ancient microorganism * primary fluid inclusion * halite * Eocene Subject RIV: DB - Geology ; Mineralogy Impact factor: 0.440, year: 2015

Unusually well preserved casts of halite crystals: A case from the Upper Frasnian of northern Lithuania

Science.gov (United States)

Rychliński, Tomasz; Jaglarz, Piotr; Uchman, Alfred; Vainorius, Julius

2014-07-01

Upper Frasnian carbonate-siliciclastics of the Stipinai Formation (northern Lithuania) comprise a bed of calcareous silty arenite with casts of halite crystals, including hopper crystals. Unusually well-preserved casts occur on the lower surface of the bed, while poorly-preserved casts are present on the upper bedding surface. The casts originated as the result of the dissolution of halite crystals which grew in the sediment. The dissolution took place during early stages of diagenesis, when host sediment was soft. Unstable cavities after crystal dissolution were filled by overlying sediment forming their casts. The collapsing sediment form sink-hole deformation structures which disturb wave-ripple cross lamination from the upper part of the bed. Dewatering pipe structures are also present. The casts and accompanying sink-hole and dewatering pipes are classified as the postdepositional deformation structures caused by haloturbation.

Isolation of circulating tumor cells by a magnesium-embedded filter

International Nuclear Information System (INIS)

Liu, Yang; Kang, Dongyang; Xu, Lei; Park, Jungwook; Zhang, Xiaoxiao; Tai, Yu-Chong; Xu, Tong; Xu, Yucheng; Chang, Jay Han-Chieh; Goldkorn, Amir

2015-01-01

Circulating tumor cells (CTCs) are rare cancer cells that are shed by tumors into the bloodstream and that can be valuable biomarkers for various types of cancers. However, CTCs captured on the filter could not be released easily using the existing CTC analysis platforms based on size. To address this limitation, we have developed a novel magnesium (Mg)-embedded cell filter for capture, release and isolation of CTCs. The CTC-filter consists of a thin Ebeam-deposited Mg layer embedded between two parylene-C (PA-C) layers with designed slots for filtration and CTC capture. Thin Mg film has proved highly biocompatible and can be etched in saline, PBS and Dulbecco’s modified eagle medium (DMEM) etc, properties that are of great benefit to help dissociate the filter and thus release the cells. The finite element method (FEM) analysis was performed on the Mg etching process in DMEM for the structure design. After the filtration process, the filter was submerged in DMEM to facilitate Mg etching. The top PA-C filter pieces break apart from the bottom after Mg completely dissolves, enabling captured CTCs to detach. The released CTC can be easily aspirated into a micropipette for further analysis. Thus, the Mg-embedded cell filter provides a new and effective approach for CTCs isolation from the filter, making this a promising new strategy for cancer detection. (paper)

Vision-based Nano Robotic System for High-throughput Non-embedded Cell Cutting.

Science.gov (United States)

Shang, Wanfeng; Lu, Haojian; Wan, Wenfeng; Fukuda, Toshio; Shen, Yajing

2016-03-04

Cell cutting is a significant task in biology study, but the highly productive non-embedded cell cutting is still a big challenge for current techniques. This paper proposes a vision-based nano robotic system and then realizes automatic non-embedded cell cutting with this system. First, the nano robotic system is developed and integrated with a nanoknife inside an environmental scanning electron microscopy (ESEM). Then, the positions of the nanoknife and the single cell are recognized, and the distance between them is calculated dynamically based on image processing. To guarantee the positioning accuracy and the working efficiency, we propose a distance-regulated speed adapting strategy, in which the moving speed is adjusted intelligently based on the distance between the nanoknife and the target cell. The results indicate that the automatic non-embedded cutting is able to be achieved within 1-2 mins with low invasion benefiting from the high precise nanorobot system and the sharp edge of nanoknife. This research paves a way for the high-throughput cell cutting at cell's natural condition, which is expected to make significant impact on the biology studies, especially for the in-situ analysis at cellular and subcellular scale, such as cell interaction investigation, neural signal transduction and low invasive cell surgery.

Thresholds of Detection and Identification of Halite Nodule Habitats in the Atacama Desert Using Remote Imaging

Science.gov (United States)

Phillips, M. S.; Moersch, J. E.; Cabrol, N. A.; Davila, A. F.

2018-01-01

The guiding theme of Mars exploration is shifting from global and regional habitability assessment to biosignature detection. To locate features likely to contain biosignatures, it is useful to focus on the reliable identification of specific habitats with high biosignature preservation potential. Proposed chloride deposits on Mars may represent evaporitic environments conducive to the preservation of biosignatures. Analogous chloride- bearing, salt-encrusted playas (salars) are a habitat for life in the driest parts of the Atacama Desert, and are also environments with a taphonomic window. The specific geologic features that harbor and preserve microorganisms in Atacama salars are sub- meter to meter scale salt protuberances, or halite nodules. This study focuses on the ability to recognize and map halite nodules using images acquired from an unmanned aerial vehicle (UAV) at spatial resolutions ranging from mm/pixel to that of the highest resolution orbital images available for Mars.

Vision-based Nano Robotic System for High-throughput Non-embedded Cell Cutting

Science.gov (United States)

Shang, Wanfeng; Lu, Haojian; Wan, Wenfeng; Fukuda, Toshio; Shen, Yajing

2016-03-01

Cell cutting is a significant task in biology study, but the highly productive non-embedded cell cutting is still a big challenge for current techniques. This paper proposes a vision-based nano robotic system and then realizes automatic non-embedded cell cutting with this system. First, the nano robotic system is developed and integrated with a nanoknife inside an environmental scanning electron microscopy (ESEM). Then, the positions of the nanoknife and the single cell are recognized, and the distance between them is calculated dynamically based on image processing. To guarantee the positioning accuracy and the working efficiency, we propose a distance-regulated speed adapting strategy, in which the moving speed is adjusted intelligently based on the distance between the nanoknife and the target cell. The results indicate that the automatic non-embedded cutting is able to be achieved within 1-2 mins with low invasion benefiting from the high precise nanorobot system and the sharp edge of nanoknife. This research paves a way for the high-throughput cell cutting at cell’s natural condition, which is expected to make significant impact on the biology studies, especially for the in-situ analysis at cellular and subcellular scale, such as cell interaction investigation, neural signal transduction and low invasive cell surgery.

Constitutive model of creep in polycrystalline halite based on workhardening and recovery

International Nuclear Information System (INIS)

Munson, D.E.

1993-01-01

A multimechanism constitutive model of creep has been developed which incorporates the workhardening and recovery transient creep behavior. This model has been applied to the creep of polycrystalline halite. The specific application of the model is in the calculation of the closure of underground rooms in layered salt deposits. Through the use of finite element calculations, this model, with appropriate laboratory material parameters and a Tresca flow potential, has predicted the measured closure of a number of large in situ experimental rooms

Hydrogel-embedded endothelial progenitor cells evade LPS and mitigate endotoxemia.

Science.gov (United States)

Ghaly, Tammer; Rabadi, May M; Weber, Mia; Rabadi, Seham M; Bank, Michael; Grom, John M; Fallon, John T; Goligorsky, Michael S; Ratliff, Brian B

2011-10-01

Sepsis and its complications are associated with poor clinical outcomes. The circulatory system is a well-known target of lipopolysaccharide (LPS). Recently, several clinical studies documented mobilization of endothelial progenitor cells (EPCs) during endotoxemia, with the probability of patients' survival correlating with the rise in circulating EPCs. This fact combined with endotoxemia-induced vascular injury led us to hypothesize that the developing functional EPC incompetence could impede vascular repair and that adoptive transfer of EPCs could improve hemodynamics in endotoxemia. We used LPS injection to model endotoxemia. EPCs isolated from endotoxemic mice exhibited impaired clonogenic potential and LPS exerted Toll-like receptor 4-mediated cytotoxic effects toward EPCs, which was mitigated by embedding them in hyaluronic acid (HA) hydrogels. Therefore, intact EPCs were either delivered intravenously or embedded within pronectin-coated HA hydrogels. Adoptive transfer of EPCs in LPS-injected mice improved control of blood pressure and reduced hepatocellular and renal dysfunction. Specifically, EPC treatment was associated with the restoration of renal microcirculation and improved renal function. EPC therapy was most efficient when cells were delivered embedded in HA hydrogel. These findings establish major therapeutic benefits of adoptive transfer of EPCs, especially when embedded in HA hydrogels, in mice with LPS-induced endotoxemia, and they argue that hemodynamic and renal abnormalities of endotoxemia are in significant part due to developing incompetence of endogenous EPCs.

Optimization of the formation of embedded multicellular spheroids of MCF-7 cells: How to reliably produce a biomimetic 3D model.

Science.gov (United States)

Zhang, Wenli; Li, Caibin; Baguley, Bruce C; Zhou, Fang; Zhou, Weisai; Shaw, John P; Wang, Zhen; Wu, Zimei; Liu, Jianping

2016-12-15

To obtain a multicellular MCF-7 spheroid model to mimic the three-dimensional (3D) of tumors, the microwell liquid overlay (A) and hanging-drop/agar (B) methods were first compared for their technical parameters. Then a method for embedding spheroids within collagen was optimized. For method A, centrifugation assisted cells form irregular aggregates but not spheroids. For method B, an extended sedimentation period of over 24 h for cell suspensions and increased viscosity of the culture medium using methylcellulose were necessary to harvest a dense and regular cell spheroid. When the number was less than 5000 cells/drop, embedded spheroids showed no tight cores and higher viability than the unembedded. However, above 5000 cells/drop, cellular viability of embedded spheroids was not significantly different from unembedded spheroids and cells invading through the collagen were in a sun-burst pattern with tight cores. Propidium Iodide staining indicated that spheroids had necrotic cores. The doxorubicin cytotoxicity demonstrated that spheroids were less susceptible to DOX than their monolayer cells. A reliable and reproducible method for embedding spheroids using the hanging-drop/agarose method within collagen is described herein. The cell culture model can be used to guide experimental manipulation of 3D cell cultures and to evaluate anticancer drug efficacy. Copyright © 2016 Elsevier Inc. All rights reserved.

Embedded Metal Electrode for Organic-Inorganic Hybrid Nanowire Solar Cells.

Science.gov (United States)

Um, Han-Don; Choi, Deokjae; Choi, Ahreum; Seo, Ji Hoon; Seo, Kwanyong

2017-06-27

We demonstrate here an embedded metal electrode for highly efficient organic-inorganic hybrid nanowire solar cells. The electrode proposed here is an effective alternative to the conventional bus and finger electrode which leads to a localized short circuit at a direct Si/metal contact and has a poor collection efficiency due to a nonoptimized electrode design. In our design, a Ag/SiO 2 electrode is embedded into a Si substrate while being positioned between Si nanowire arrays underneath poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), facilitating suppressed recombination at the Si/Ag interface and notable improvements in the fabrication reproducibility. With an optimized microgrid electrode, our 1 cm 2 hybrid solar cells exhibit a power conversion efficiency of up to 16.1% with an open-circuit voltage of 607 mV and a short circuit current density of 34.0 mA/cm 2 . This power conversion efficiency is more than twice as high as that of solar cells using a conventional electrode (8.0%). The microgrid electrode significantly minimizes the optical and electrical losses. This reproducibly yields a superior quantum efficiency of 99% at the main solar spectrum wavelength of 600 nm. In particular, our solar cells exhibit a significant increase in the fill factor of 78.3% compared to that of a conventional electrode (61.4%); this is because of the drastic reduction in the metal/contact resistance of the 1 μm-thick Ag electrode. Hence, the use of our embedded microgrid electrode in the construction of an ideal carrier collection path presents an opportunity in the development of highly efficient organic-inorganic hybrid solar cells.

Does Ice Dissolve or Does Halite Melt? A Low-Temperature Liquidus Experiment for Petrology Classes.

Science.gov (United States)

Brady, John B.

1992-01-01

Measurement of the compositions and temperatures of H2O-NaCl brines in equilibrium with ice can be used as an easy in-class experimental determination of a liquidus. This experiment emphasizes the symmetry of the behavior of brines with regard to the minerals ice and halite and helps to free students from the conceptual tethers of one-component…

Atomic force microscopy and confocal laser scanning microscopy on the cytoskeleton of permeabilised and embedded cells

International Nuclear Information System (INIS)

Meller, Karl; Theiss, Carsten

2006-01-01

We describe a technical method of cell permeabilisation and embedding to study the organisation and distribution of intracellular proteins with aid of atomic force microscopy and confocal laser scanning microscopy in identical areas. While confocal laser scanning microscopy is useful for the identification of certain proteins subsequent labelling with markers or antibodies, atomic force microscopy allows the observation of macromolecular structures in fixed and living cells. To demonstrate the field of application of this preparatory technique, cells were permeabilised, fixed, and the actin cytoskeleton was stained with phalloidin-rhodamine. Confocal laser scanning microscopy was used to show the organisation of these microfilaments, e.g. geodesic dome structures. Thereafter, cells were embedded in Durcupan water-soluble resin, followed by UV-polymerisation of resin at 4 o C. This procedure allowed intracellular visualisation of the cell nucleus or cytoskeletal elements by atomic force microscopy, for instance to analyse the globular organisation of actin filaments. Therefore, this method offers a great potential to combine both microscopy techniques in order to understand and interpret intracellular protein relations, for example, the biochemical and morphological interaction of the cytoskeleton

Geochemical models of the precipitation of halite (NaCl) in gas fields; Modelamiento geoquimico de la precipitacion de Halita (NaCl) en yacimientos de gas

Energy Technology Data Exchange (ETDEWEB)

Lombana O, Jose L; Jaramillo, Elizabeth A; Alzate E, Guillermo A

2005-07-01

The reservoir modeling is a tool that every day takes more importance in the petroleum industry due to multiple problems presented an also that can be afforded by it during the production of reservoir fluids from the porous media in petroleum reservoir. One of these is the formation damage which is reflected as a petrophysic properties change, caused among other factors by the scale precipitation of halite (NaCl) as a consequence of the original state alteration and thermodynamic balance disruption between the porous media and the fluids inside by the gas flow. By the gas flow over the connate water, the porous media reduce its water saturation due to water transferring from liquid to gas state. In this study, a numeric model is developed to model the formation damage for halite precipitation. The model covers one-dimensional monophasic and iso thermic gas flow and evaluates the porosity and permeability changes of porous media due to halite precipitation. The model application for different conditions of temperature, connate water salinity, water saturation,and porosity indicates the following: the biggest damage is caused to the beginning of the porous media,temperature influences considerably the water vaporization rate and therefore the amount of halite precipitation, the lower the porosity of the porous media the bigger the formation damage degree, and finally, higher salinity and water saturation for the connate water in the porous media higher the formation damage degree is reached by the gas flow.

Two-way coupling of magnetohydrodynamic simulations with embedded particle-in-cell simulations

Science.gov (United States)

Makwana, K. D.; Keppens, R.; Lapenta, G.

2017-12-01

We describe a method for coupling an embedded domain in a magnetohydrodynamic (MHD) simulation with a particle-in-cell (PIC) method. In this two-way coupling we follow the work of Daldorff et al. (2014) [19] in which the PIC domain receives its initial and boundary conditions from MHD variables (MHD to PIC coupling) while the MHD simulation is updated based on the PIC variables (PIC to MHD coupling). This method can be useful for simulating large plasma systems, where kinetic effects captured by particle-in-cell simulations are localized but affect global dynamics. We describe the numerical implementation of this coupling, its time-stepping algorithm, and its parallelization strategy, emphasizing the novel aspects of it. We test the stability and energy/momentum conservation of this method by simulating a steady-state plasma. We test the dynamics of this coupling by propagating plasma waves through the embedded PIC domain. Coupling with MHD shows satisfactory results for the fast magnetosonic wave, but significant distortion for the circularly polarized Alfvén wave. Coupling with Hall-MHD shows excellent coupling for the whistler wave. We also apply this methodology to simulate a Geospace Environmental Modeling (GEM) challenge type of reconnection with the diffusion region simulated by PIC coupled to larger scales with MHD and Hall-MHD. In both these cases we see the expected signatures of kinetic reconnection in the PIC domain, implying that this method can be used for reconnection studies.

ITO with embedded silver grids as transparent conductive electrodes for large area organic solar cells

Science.gov (United States)

Patil, Bhushan R.; Mirsafaei, Mina; Piotr Cielecki, Paweł; Fernandes Cauduro, André Luis; Fiutowski, Jacek; Rubahn, Horst-Günter; Madsen, Morten

2017-10-01

In this work, development of semi-transparent electrodes for efficient large area organic solar cells (OSCs) has been demonstrated. Electron beam evaporated silver grids were embedded in commercially available ITO coatings on glass, through a standard negative photolithography process, in order to improve the conductivity of planar ITO substrates. The fabricated electrodes with embedded line and square patterned Ag grids reduced the sheet resistance of ITO by 25% and 40%, respectively, showing optical transmittance drops of less than 6% within the complete visible light spectrum for both patterns. Solution processed bulk heterojunction OSCs based on PTB7:[70]PCBM were fabricated on top of these electrodes with cell areas of 4.38 cm2, and the performance of these OSCs was compared to reference cells fabricated on pure ITO electrodes. The Fill Factor (FF) of the large-scale OSCs fabricated on ITO with embedded Ag grids was enhanced by 18% for the line grids pattern and 30% for the square grids pattern compared to that of the reference OSCs. The increase in the FF was directly correlated to the decrease in the series resistance of the OSCs. The maximum power conversion efficiency (PCE) of the OSCs was measured to be 4.34%, which is 23% higher than the PCE of the reference OSCs. As the presented method does not involve high temperature processing, it could be considered a general approach for development of large area organic electronics on solvent resistant, flexible substrates.

New approach to invariant-embedding methods in reactor physics calculations

International Nuclear Information System (INIS)

Forsbacka, M.J.; Rydin, R.A.

1997-01-01

Invariant-embedding methods offer an alternative approach to modeling physical phenomena and solving mathematical problems. Invariant embedding allows one to express traditional boundary-value problems as initial-value problems. In doing this, one effectively reformulates a problem to be solved in terms of an embedding parameter. In this paper, a hybrid method that consists of Monte Carlo-generated response functions that describe the neutronic properties of local spatial cells are coupled together in a global reactor model using the invariant embedding methodology, where the system multiplication factor k eff is used as the embedding parameter. Thus, k eff is computed directly rather than as the result of a secondary eigenvalue calculation. Because the response functions can represent any arbitrary material distribution within a local cell, this method shows promise to accurately assess the change in reactivity due to core disruptive accidents and other changes in system configuration such as changing control rod positions. This paper reports a series of proof-of-concept calculations that assess this method

Isotopically heavy carbon in C21 to C25 regular isoprenoids in halite-rich deposits from the Sdm Formation, Dead Sea, Israel

NARCIS (Netherlands)

Sinninghe Damsté, J.S.; Grice, K.; Schouten, S.; Nissenbaum, A.; Charrach, J.

1998-01-01

A series of Miocene/Pliocene halite deposits (with extremely low organic carbon contents) from the Sdom Formation (Dead Sea Basin, Israel) have been studied. Distributions and contents of biomarkers have been determined using GC MS and irm-GCMS analyses, respectively. The hydrocarbon fractions

In situ metabolism in halite endolithic microbial communities of the hyperarid Atacama Desert

Directory of Open Access Journals (Sweden)

Alfonso F Davila

2015-10-01

Full Text Available The Atacama Desert of northern Chile is one of the driest regions on Earth, with areas that exclude plants and where soils have extremely low microbial biomass. However, in the driest parts of the desert there are microorganisms that colonize the interior of halite nodules in fossil continental evaporites, where they are sustained by condensation of atmospheric water triggered by the salt substrate. Using a combination of in situ observations of variable chlorophyll fluorescence and controlled laboratory experiments, we show that this endolithic community is capable of carbon fixation both through oxygenic photosynthesis and potentially ammonia oxidation. We also present evidence that photosynthetic activity is finely tuned to moisture availability and solar insolation and can be sustained for days, and perhaps longer, after a wetting event. This is the first demonstration of in situ active metabolism in the hyperarid core of the Atacama Desert, and it provides the basis for proposing a self-contained, endolithic community that relies exclusively on non-rainfall sources of water. Our results contribute to an increasing body of evidence that even in hyperarid environments active metabolism, adaptation and growth can occur in highly specialized microhabitats.

Comparison in performance of sediment microbial fuel cells according to depth of embedded anode.

Science.gov (United States)

An, Junyeong; Kim, Bongkyu; Nam, Jonghyeon; Ng, How Yong; Chang, In Seop

2013-01-01

Five rigid graphite plates were embedded in evenly divided sections of sediment, ranging from 2 cm (A1) to 10 cm (A5) below the top sediment layer. The maximum power and current of the MFCs increased in depth order; however, despite the increase in the internal resistance, the power and current density of the A5 MFC were 2.2 and 3.5 times higher, respectively, than those of the A1 MFC. In addition, the anode open circuit potentials (OCPs) of the sediment microbial fuel cells (SMFCs) became more negative with sediment depth. Based on these results, it could be then concluded that as the anode-embedding depth increases, that the anode environment is thermodynamically and kinetically favorable to anodophiles or electrophiles. Therefore, the anode-embedding depth should be considered an important parameter that determines the performance of SMFCs, and we posit that the anode potential could be one indicator for selecting the anode-embedding depth. Copyright © 2012 Elsevier Ltd. All rights reserved.

Modeling of brine migration in halite

International Nuclear Information System (INIS)

Cheung, H.; Fuller, M.E.; Gaffney, E.S.

1979-01-01

When canisters containing radwastes are emplaced in a repository the heat produced by the decaying radwaste will cause moderate thermal gradients to develop which will cause the brine present in a halite medium (salt deposits) to accumulate around the canister. Four different models of the migration process have been reviewed to determine their suitability as a working model. One model predicts that inclusions smaller than 0.1 mm dimension probably will not migrate. The other models do not consider size as a factor. Thermal diffusion (Soret effect) is considered insignificant in three models, while in the fourth model it is added to the concentration diffusion term. The following conclusions can be made: Temperature is the most significant parameter in all models and must be known as a function of time, and distance from the canister. All four models predict about the same migration velocity for it is a given set of conditions; for 100 0 C and 1 0 C/cm thermal gradient, it is 3.0, 4.8, 5.6 and 6.4 mm/y. Diffusion of ions through the brine inclusions is the rate controlling mechanism. The difference between the thermal gradients in the liquid and in the solid should always be considered and is a function of droplet shape. The model based upon work by Nernst is easiest to use, but it predicts the lowest migration rate. The maximum volume of pure brine accumulated at the canister surface would be less than 20-40 liters in 50 years, for a canister initial thermal power of 3.5 kW.Bitterns would migrate proportionately less volume. A computer code, BRINE, was developed to make these calculations by means of any of the four models

The origin of enhanced optical absorption in solar cells with metal nanoparticles embedded in the active layer

KAUST Repository

Lee, Jung-Yong

2010-04-29

We analyze the enhancement in optical absorption of an absorbing medium when spherical metal nanoparticles are embedded in it. Our analysis uses generalized Mie theory to calculate the absorbed optical power as a function of the distance from the metal nanoparticle. This analysis is used to evaluate the potential of enhancing optical absorption in thin-film solar cells by embedding spherical metal nanoparticles. We consider the trade-off between maximizing overall optical absorption and ensuring that a large fraction of the incident optical power is dissipated in the absorbing host medium rather than in the metal nanoparticle. We show that enhanced optical absorption results from strong scattering by the metal nanoparticle which locally enhances the optical electric fields. We also discuss the effect of a thin dielectric encapsulation of the metal nanoparticles. ©2010 Optical Society of America.

The origin of enhanced optical absorption in solar cells with metal nanoparticles embedded in the active layer

KAUST Repository

Lee, Jung-Yong; Peumans, Peter

2010-01-01

We analyze the enhancement in optical absorption of an absorbing medium when spherical metal nanoparticles are embedded in it. Our analysis uses generalized Mie theory to calculate the absorbed optical power as a function of the distance from the metal nanoparticle. This analysis is used to evaluate the potential of enhancing optical absorption in thin-film solar cells by embedding spherical metal nanoparticles. We consider the trade-off between maximizing overall optical absorption and ensuring that a large fraction of the incident optical power is dissipated in the absorbing host medium rather than in the metal nanoparticle. We show that enhanced optical absorption results from strong scattering by the metal nanoparticle which locally enhances the optical electric fields. We also discuss the effect of a thin dielectric encapsulation of the metal nanoparticles. ©2010 Optical Society of America.

Solubility relations in the ternary system NaCl-CsCl-H2O at 1 atm. 1. Solubilities of halite from 20 to 100 °C

Science.gov (United States)

Chou, I.-Ming; Lee, R.D.

1983-01-01

Solubilities of halite in the ternary system NaCl-CsCl-H2O have been determined by the visual polythermal method at 1 atm from 20 to 100??C along five constant CsCl/(CsCl + H2O) weight ratio lines. These five constant weight ratios are 0.1, 0.2, 0.3, 0.4, and 0.5. The maximum uncertainties in these measurements are ??0.02 wt % NaCl and ??0.15??C. The data along each constant CsCl/(CsCl + H2O) weight ratio line were regressed to a smooth curve. The maximum deviation of the measured solubilities from the smooth curves is 0.06 wt % NaCl. Isothermal solubilities of halite were calculated from smoothed curves at 25, 50, and 75??C.

Embedded 32-bit Differential Pulse Voltammetry (DPV) Technique for 3-electrode Cell Sensing

Science.gov (United States)

N, Aqmar N. Z.; Abdullah, W. F. H.; Zain, Z. M.; Rani, S.

2018-03-01

This paper addresses the development of differential pulse voltammetry (DPV) embedded algorithm using an ARM cortex processor with new developed potentiostat circuit design for in-situ 3-electrode cell sensing. This project is mainly to design a low cost potentiostat for the researchers in laboratories. It is required to develop an embedded algorithm for analytical technique to be used with the designed potentiostat. DPV is one of the most familiar pulse technique method used with 3-electrode cell sensing in chemical studies. Experiment was conducted on 10mM solution of Ferricyanide using the designed potentiostat and the developed DPV algorithm. As a result, the device can generate an excitation signal of DPV from 0.4V to 1.2V and produced a peaked voltammogram with relatively small error compared to the commercial potentiostat; which is only 6.25% difference in peak potential reading. The design of potentiostat device and its DPV algorithm is verified.

ITO with embedded silver grids as transparent conductive electrodes for large area organic solar cells

DEFF Research Database (Denmark)

Patil, Bhushan Ramesh; Mirsafaei, Mina; Cielecki, Pawel Piotr

2017-01-01

In this work, development of semi-transparent electrodes for efficient large area organic solar cells (OSCs) has been demonstrated. Electron beam evaporated silver grids were embedded in commercially available ITO coatings on glass, through a standard negative photolithography process, in order...... patterns. Solution processed bulk heterojunction OSCs based on PTB7:[70]PCBM were fabricated on top of these electrodes with cell areas of 4.38 cm2, and the performance of these OSCs was compared to reference cells fabricated on pure ITO electrodes. The Fill Factor of the large-scale OSCs fabricated on ITO...... with embedded Ag grids was enhanced by 18 % for the line grids pattern and 30 % for the square grids pattern compared to that of the reference OSCs. The increase in the Fill Factor was directly correlated to the decrease in the series resistance of the OSCs. The maximum power conversion efficiency (PCE...

Identification of 5-hydroxytryptamine-producing cells by detection of fluorescence in paraffin-embedded tissue sections

Directory of Open Access Journals (Sweden)

Y. Kaneko

2016-09-01

Full Text Available 5-Hydroxytryptamine (5-HT produced by enterochromaffin (EC cells is an important enteric mucosal signaling ligand and has been implicated in several gastrointestinal diseases, including inflammatory bowel disease and functional disorders such as irritable bowel syndrome. The present study reports a new, simple and rapid visualization method of 5-HT-producing EC cells utilizing detection of autofluorescence in paraffin-embedded tissue sections after formalin fixation. In human samples, there was a high incidence of autofluorescence+ cells in the 5-HT+ cells in the pyloric, small intestinal and colonic glands, while co-localization was lacking between autofluorescence+ and gastrin+ cells in the pyloric and small intestinal glands. Autofluorescence+ EC cells were detected in the colon of mice and rats. Autofluorescence+ cells were also observed in 5-HT+ β cells in the pancreatic islets of Langerhans in pregnant mice, while non-pregnant mouse pancreatic islet cells showed no 5-HT immunoreactivity or autofluorescence. These results suggest that autofluorescence+ cells are identical to 5-HT+ cells, and the source of autofluorescence may be 5-HT itself or molecules related to its synthesis or degradation. This autofluorescence signal detection method may be applicable for monitoring of inflammatory status of inflammatory bowel diseases in both the experimental and clinical settings.

Electrohydrodynamic spinning of random-textured silver webs for electrodes embedded in flexible organic solar cells

Science.gov (United States)

Yoon, Dai Geon; Chin, Byung Doo; Bail, Robert

2017-03-01

A convenient process for fabricating a transparent conducting electrode on a flexible substrate is essential for numerous low-cost optoelectronic devices, including organic solar cells (OSCs), touch sensors, and free-form lighting applications. Solution-processed metal-nanowire arrays are attractive due to their low sheet resistance and optical clarity. However, the limited conductance at wire junctions and the rough surface topology still need improvement. Here, we present a facile process of electrohydrodynamic spinning using a silver (Ag) - polymer composite paste with high viscosity. Unlike the metal-nanofiber web formed by conventional electrospinning, a relatively thick, but still invisible-to-naked eye, Ag-web random pattern was formed on a glass substrate. The process parameters such as the nozzle diameter, voltage, flow rate, standoff height, and nozzle-scanning speed, were systematically engineered. The formed random texture Ag webs were embedded in a flexible substrate by in-situ photo-polymerization, release from the glass substrate, and post-annealing. OSCs with a donor-acceptor polymeric heterojunction photoactive layer were prepared on the Ag-web-embedded flexible films with various Ag-web densities. The short-circuit current and the power conversion efficiency of an OSC with a Ag-web-embedded electrode were not as high as those of the control sample with an indium-tin-oxide electrode. However, the Ag-web textures embedded in the OSC served well as electrodes when bent (6-mm radius), showing a power conversion efficiency of 2.06% (2.72% for the flat OSC), and the electrical stability of the Ag-web-textured patterns was maintained for up to 1,000 cycles of bending.

Preliminary report on fluid inclusions from halites in the Castile and lower Salado formations of the Delaware Basin, southeastern New Mexico

International Nuclear Information System (INIS)

Stein, C.L.

1985-09-01

A suite of samples composed primarily of halite from the upper Castile and lower Salado Formations of the Permian Basin was selected from Waste Isolation Pilot Plant (WIPP) core for a reconnaissance study of fluid inclusions. Volume percent of these trapped fluids averaged 0.7% to 1%. Freezing-point depressions varied widely and appeared to be unrelated to fluid-inclusion type, to sedimentary facies, or to stratigraphic depth. However, because very low freezing points were usually associated with anhydrite, a relation may exist between freezing-point data and lithology. Dissolved sulfate values were constant through the Castile, then decreased markedly with lesser depth in the lower Salado. This trend correlates very well with observed mineralogy and is consistent with an interpretation of the occurrence of secondary polyhalite as a result of gypsum or anhydrite alteration with simultaneous consumption of dissolved sulfate from the coexisting fluids. Together with the abundance and distribution of fluid inclusions in primary or ''hopper'' crystal structures, this evidence suggests that inclusions seen in these halites did not migrate any significant geographical distance since their formation. 28 refs., 17 figs., 2 tabs

Silicon nanocrystals embedded in silicon carbide for tandem solar cell applications

International Nuclear Information System (INIS)

Schnabel, Manuel

2015-01-01

Tandem solar cells consist of multiple individual solar cells stacked in order of increasing bandgap, with the cell with highest bandgap towards the incident light. This allows photons to be absorbed in the cell that will convert them to electricity with the greatest efficiency, and is the only solar cell concept to surpass the theoretical efficiency limit of a conventional solar cell so far. This work is concerned with the development of silicon nanocrystals (Si NCs) embedded in silicon carbide, which are expected to have a higher bandgap than bulk Si due to quantum confinement, for use in the top cell of a two-junction tandem cell. Charge carrier transport and recombination were investigated as a function of various parameters. Distortion of luminescence spectra by optical interference was highlighted and a robust model to describe transport of majority carriers was developed. Furthermore, a range of processing steps required to produce a Si NC-based tandem cell were studied, culminating in the preparation of the first Si NC-based tandem cells. The resulting cells exhibited open-circuit voltages of 900 mV, demonstrating tandem cell functionality.

Polymorphic Embedding of DSLs

DEFF Research Database (Denmark)

Hofer, Christian; Ostermann, Klaus; Rendel, Tillmann

2008-01-01

propose polymorphic embedding of DSLs, where many different interpretations of a DSL can be provided as reusable components, and show how polymorphic embedding can be realized in the programming language Scala. With polymorphic embedding, the static type-safety, modularity, composability and rapid...

Embedding beyond electrostatics

DEFF Research Database (Denmark)

Nåbo, Lina J.; Olsen, Jógvan Magnus Haugaard; Holmgaard List, Nanna

2016-01-01

We study excited states of cholesterol in solution and show that, in this specific case, solute wave-function confinement is the main effect of the solvent. This is rationalized on the basis of the polarizable density embedding scheme, which in addition to polarizable embedding includes non-electrostatic...... repulsion that effectively confines the solute wave function to its cavity. We illustrate how the inclusion of non-electrostatic repulsion results in a successful identification of the intense π → π∗ transition, which was not possible using an embedding method that only includes electrostatics....... This underlines the importance of non-electrostatic repulsion in quantum-mechanical embedding-based methods....

WIMS/PANTHER analysis of UO2/MOX cores using embedded super-cells

International Nuclear Information System (INIS)

Knight, M.; Bryce, P.; Hall, S.

2012-01-01

This paper describes a method of analysing PWR UO 2 MOX cores with WIMS/PANTHER. Embedded super-cells, run within the reactor code, are used to correct the standard methodology of using 2-group smeared data from single assembly lattice calculations. In many other codes the weakness of this standard approach has been improved for MOX by imposing a more realistic environment in the lattice code, or by improving the sophistication of the reactor code. In this approach an intermediate set of calculations is introduced, leaving both lattice and reactor calculations broadly unchanged. The essence of the approach is that the whole core is broken down into a set of 'embedded' super-cells, each extending over just four quarter assemblies, with zero leakage imposed at the assembly mid-lines. Each supercell is solved twice, first with a detailed multi-group pin-by-pin solution, and then with the standard single assembly approach. Correction factors are defined by comparing the two solutions, and these can be applied in whole core calculations. The restriction that all such calculations are modelled with zero leakage means that they are independent of each other and of the core-wide flux shape. This allows parallel pre-calculation for the entire cycle once the loading pattern has been determined, in much the same way that single assembly lattice calculations can be pre-calculated once the range of fuel types is known. Comparisons against a whole core pin-by-pin reference demonstrates that the embedding process does not introduce a significant error, even after burnup and refuelling. Comparisons against a WIMS reference demonstrate that a pin-by-pin multi-group diffusion solution is capable of capturing the main interface effects. This therefore defines a practical approach for achieving results close to lattice code accuracy, but broadly at the cost of a standard reactor calculation. (authors)

High-efficiency near-infrared enabled planar perovskite solar cells by embedding upconversion nanocrystals.

Science.gov (United States)

Meng, Fan-Li; Wu, Jiao-Jiao; Zhao, Er-Fei; Zheng, Yan-Zhen; Huang, Mei-Lan; Dai, Li-Ming; Tao, Xia; Chen, Jian-Feng

2017-11-30

Integration of the upconversion effect in perovskite solar cells (PSCs) is a facile approach towards extending the spectral absorption from the visible to the near infrared (NIR) range and reducing the non-absorption loss of solar photons. However, the big challenge for practical application of UCNCs in planar PSCs is the poor compatibility between UCNCs and the perovskite precursor. Herein, we have subtly overcome the tough compatibility issue using a ligand-exchange strategy. For the first time, β-NaYF 4 :Yb,Er UCNCs have been embedded in situ into a CH 3 NH 3 PbI 3 layer to fabricate NIR-enabled planar PSCs. The CH 3 NH 3 I-capped UCNCs generated from the ligand-exchange were mixed with the perovskite precursor and served as nucleation sites for the UCNC-mediated heteroepitaxial growth of perovskite; moreover, the in situ embedding of UCNCs into the perovskite layer was realized during a spin-coating process. The resulting UCNC-embedded perovskite layer attained a uniform pinhole-free morphology with enlarged crystal grains and enabled NIR absorption. It also contributed to the energy transfer from the UCNCs to the perovskite and electron transport to the collecting electrode surface. The device fabricated using the UCNC-embedded perovskite film achieved an average power-conversion efficiency of 18.60% (19.70% for the best) under AM 1.5G and 0.37% under 980 nm laser, corresponding to 54% and 740-fold increase as compared to that of its counterpart without UCNCs.

Operational analysis and comparative evaluation of embedded Z-Source inverters

DEFF Research Database (Denmark)

Blaabjerg, Frede; Gao, F.; Loh, P.C.

2008-01-01

) circuitry connected instead of the generic voltage source inverter (VSI) circuitry. Further proceeding on to the topological variation, parallel embedded Z-source inverters are presented with the detailed analysis of topological configuration and operational principles showing that they are the superior......This paper presents various embedded Z-source (EZ-source) inverters broadly classified as shunt or parallel embedded Z-source inverter. Being different from the traditional Z-source inverter, EZ-source inverters are constructed by inserting dc sources into the X-shaped impedance network so...... that the dc input current flows smoothly during the whole switching period unlike the traditional Z-source inverter. This feature is interesting when PV panels or fuel cells are assumed to power load since the continuous input current flow reduces control complexity of dc source and system design burden...

Analysis of Invasion Dynamics of Matrix-Embedded Cells in a Multisample Format.

Science.gov (United States)

Van Troys, Marleen; Masuzzo, Paola; Huyck, Lynn; Bakkali, Karima; Waterschoot, Davy; Martens, Lennart; Ampe, Christophe

2018-01-01

In vitro tests of cancer cell invasion are the "first line" tools of preclinical researchers for screening the multitude of chemical compounds or cell perturbations that may aid in halting or treating cancer malignancy. In order to have predictive value or to contribute to designing personalized treatment regimes, these tests need to take into account the cancer cell environment and measure effects on invasion in sufficient detail. The in vitro invasion assays presented here are a trade-off between feasibility in a multisample format and mimicking the complexity of the tumor microenvironment. They allow testing multiple samples and conditions in parallel using 3D-matrix-embedded cells and deal with the heterogeneous behavior of an invading cell population in time. We describe the steps to take, the technical problems to tackle and useful software tools for the entire workflow: from the experimental setup to the quantification of the invasive capacity of the cells. The protocol is intended to guide researchers to standardize experimental set-ups and to annotate their invasion experiments in sufficient detail. In addition, it provides options for image processing and a solution for storage, visualization, quantitative analysis, and multisample comparison of acquired cell invasion data.

WIMS/PANTHER analysis of UO{sub 2}/MOX cores using embedded super-cells

Energy Technology Data Exchange (ETDEWEB)

Knight, M.; Bryce, P. [EDF Energy, Barnett Way, Barnwood, Gloucester (United Kingdom); Hall, S. [Advanced Modelling and Computation Group, Imperial College, London (United Kingdom)

2012-07-01

This paper describes a method of analysing PWR UO{sub 2}MOX cores with WIMS/PANTHER. Embedded super-cells, run within the reactor code, are used to correct the standard methodology of using 2-group smeared data from single assembly lattice calculations. In many other codes the weakness of this standard approach has been improved for MOX by imposing a more realistic environment in the lattice code, or by improving the sophistication of the reactor code. In this approach an intermediate set of calculations is introduced, leaving both lattice and reactor calculations broadly unchanged. The essence of the approach is that the whole core is broken down into a set of 'embedded' super-cells, each extending over just four quarter assemblies, with zero leakage imposed at the assembly mid-lines. Each supercell is solved twice, first with a detailed multi-group pin-by-pin solution, and then with the standard single assembly approach. Correction factors are defined by comparing the two solutions, and these can be applied in whole core calculations. The restriction that all such calculations are modelled with zero leakage means that they are independent of each other and of the core-wide flux shape. This allows parallel pre-calculation for the entire cycle once the loading pattern has been determined, in much the same way that single assembly lattice calculations can be pre-calculated once the range of fuel types is known. Comparisons against a whole core pin-by-pin reference demonstrates that the embedding process does not introduce a significant error, even after burnup and refuelling. Comparisons against a WIMS reference demonstrate that a pin-by-pin multi-group diffusion solution is capable of capturing the main interface effects. This therefore defines a practical approach for achieving results close to lattice code accuracy, but broadly at the cost of a standard reactor calculation. (authors)

Boys with autism spectrum disorders show superior performance on the adult Embedded Figures Test

NARCIS (Netherlands)

Schlooz, W.A.J.M.; Hulstijn, W.

2014-01-01

Weak central coherence is frequently studied using the Embedded Figures Test (EFT) yielding mixed and ambiguous results. In this study, the performance of 36 boys (9–14 years) with Autism Spectrum Disorders (ASD) is compared with that of 46 typical peers using both the children's and the adult

Embedded defects

International Nuclear Information System (INIS)

Barriola, M.; Vachaspati, T.; Bucher, M.

1994-01-01

We give a prescription for embedding classical solutions and, in particular, topological defects in field theories which are invariant under symmetry groups that are not necessarily simple. After providing examples of embedded defects in field theories based on simple groups, we consider the electroweak model and show that it contains the Z string and a one-parameter family of strings called the W(α) string. It is argued that although the members of this family are gauge equivalent when considered in isolation, each member becomes physically distinct when multistring configurations are considered. We then turn to the issue of stability of embedded defects and demonstrate the instability of a large class of such solutions in the absence of bound states or condensates. The Z string is shown to be unstable for all values of the Higgs boson mass when θ W =π/4. W strings are also shown to be unstable for a large range of parameters. Embedded monopoles suffer from the Brandt-Neri-Coleman instability. Finally, we connect the electroweak string solutions to the sphaleron

Direct implantation versus platelet-rich fibrin-embedded adipose-derived mesenchymal stem cells in treating rat acute myocardial infarction.

Science.gov (United States)

Sun, Cheuk-Kwan; Zhen, Yen-Yi; Leu, Steve; Tsai, Tzu-Hsien; Chang, Li-Teh; Sheu, Jiunn-Jye; Chen, Yung-Lung; Chua, Sarah; Chai, Han-Tan; Lu, Hung-I; Chang, Hsueh-Wen; Lee, Fan-Yen; Yip, Hon-Kan

2014-05-15

This study tested whether adipose-derived mesenchymal stem cells (ADMSC) embedded in platelet-rich fibrin (PRF) scaffold is superior to direct ADMSC implantation in improving left ventricular (LV) performance and reducing LV remodeling in a rat acute myocardial infarction (AMI) model of left anterior descending coronary artery (LAD) ligation. Twenty-eight male adult Sprague Dawley rats equally divided into group 1 [sham control], group 2 (AMI only), group 3 (AMI+direct ADMSC implantation), and group 4 (AMI+PRF-embedded autologous ADMSC) were sacrificed on day 42 after AMI. LV systolic and diastolic dimensions and volumes, and infarct/fibrotic areas were highest in group 2, lowest in group 1 and significantly higher in group 3 than in group 4, whereas LV performance and LV fractional shortening exhibited a reversed pattern (p<0.005). Protein expressions of inflammation (oxidative stress, IL-1β, MMP-9), apoptosis (mitochondrial Bax, cleaved PARP), fibrosis (Smad3, TGF-β), and pressure-overload biomarkers (BNP, MHC-β) displayed a pattern similar to that of LV dimensions, whereas anti-inflammatory (IL-10), anti-apoptotic (Bcl-2), and anti-fibrotic (Smad1/5, BMP-2) indices showed a pattern similar to that of LV performance among the four groups (all p<0.05). Angiogenesis biomarkers at protein (CXCR4, SDF-1α, VEGF), cellular (CD31+, CXCR4+, SDF-1α+), and immunohistochemical (small vessels) levels, and cardiac stem cell markers (C-kit+, Sca-1+) in infarct myocardium were highest in group 4, lowest in group 1, and significantly higher in group 3 than in group 2 (all p<0.005). PRF-embedded ADMSC is superior to direct ADMSC implantation in preserving LV function and attenuating LV remodeling. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

A bioartificial renal tubule device embedding human renal stem/progenitor cells.

Directory of Open Access Journals (Sweden)

Anna Giovanna Sciancalepore

Full Text Available We present a bio-inspired renal microdevice that resembles the in vivo structure of a kidney proximal tubule. For the first time, a population of tubular adult renal stem/progenitor cells (ARPCs was embedded into a microsystem to create a bioengineered renal tubule. These cells have both multipotent differentiation abilities and an extraordinary capacity for injured renal cell regeneration. Therefore, ARPCs may be considered a promising tool for promoting regenerative processes in the kidney to treat acute and chronic renal injury. Here ARPCs were grown to confluence and exposed to a laminar fluid shear stress into the chip, in order to induce a functional cell polarization. Exposing ARPCs to fluid shear stress in the chip led the aquaporin-2 transporter to localize at their apical region and the Na(+K(+ATPase pump at their basolateral portion, in contrast to statically cultured ARPCs. A recovery of urea and creatinine of (20±5% and (13±5%, respectively, was obtained by the device. The microengineered biochip here-proposed might be an innovative "lab-on-a-chip" platform to investigate in vitro ARPCs behaviour or to test drugs for therapeutic and toxicological responses.

Platelet lysate embedded scaffolds for skin regeneration.

Science.gov (United States)

Sandri, Giuseppina; Bonferoni, Maria Cristina; Rossi, Silvia; Ferrari, Franca; Mori, Michela; Cervio, Marila; Riva, Federica; Liakos, Ioannis; Athanassiou, Athanassia; Saporito, Francesca; Marini, Lara; Caramella, Carla

2015-04-01

The work presents the development of acellular scaffolds extemporaneously embedded with platelet lysate (PL), as an innovative approach in the field of tissue regeneration/reparation. PL embedded scaffolds should have a tridimensional architecture to support cell migration and growth, in order to restore skin integrity. For this reason, chondroitin sulfate (CS) was associated with sodium alginate (SA) to prepare highly porous systems. The developed scaffolds were characterized for chemical stability to γ-radiation, morphology, hydration and mechanical properties. Moreover, the capability of fibroblasts and endothelial cells to populate the scaffold was evaluated by means of proliferation test 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and confocal laser scanning microscopy study. The scaffolds, not altered by sterilization, were characterized by limited swelling and high flexibility, by foam-like structure with bubbles that formed a high surface area and irregular texture suitable for cell adhesion. Cell growth and scaffold population were evident on the bubble surface, where the cells appeared anchored to the scaffold structure. Scaffold network based on CS and SA demonstrated to be an effective support to enhance and to allow fibroblasts and endothelial cells (human umbilical vein endothelial cells, HUVEC) adhesion and proliferation. In particular, it could be hypothesized that cell adhesion was facilitated by the synergic effect of PL and CS. Although further in vivo evaluation is needed, on the basis of in vitro results, PL embedded scaffolds seem promising systems for skin wound healing.

Web Server Embedded System

Directory of Open Access Journals (Sweden)

Adharul Muttaqin

2014-07-01

HTTPD and Tiny HTTPD which has compatibility features in the use of embedded systems using beagleboard terms of CPU consumption and memory. Results showed that in terms of CPU consumption on embedded systems beagleboard more advisable use Light HTTPD than tiny HTTPD because there are differences very significant CPU load between both the web service. Keywords: embedded system, web server

A novel sample preparation method to avoid influence of embedding medium during nano-indentation

Science.gov (United States)

Meng, Yujie; Wang, Siqun; Cai, Zhiyong; Young, Timothy M.; Du, Guanben; Li, Yanjun

2013-02-01

The effect of the embedding medium on the nano-indentation measurements of lignocellulosic materials was investigated experimentally using nano-indentation. Both the reduced elastic modulus and the hardness of non-embedded cell walls were found to be lower than those of the embedded samples, proving that the embedding medium used for specimen preparation on cellulosic material during nano-indentation can modify cell-wall properties. This leads to structural and chemical changes in the cell-wall constituents, changes that may significantly alter the material properties. Further investigation was carried out to detect the influence of different vacuum times on the cell-wall mechanical properties during the embedding procedure. Interpretation of the statistical analysis revealed no linear relationships between vacuum time and the mechanical properties of cell walls. The quantitative measurements confirm that low-viscosity resin has a rapid penetration rate early in the curing process. Finally, a novel sample preparation method aimed at preventing resin diffusion into lignocellulosic cell walls was developed using a plastic film to wrap the sample before embedding. This method proved to be accessible and straightforward for many kinds of lignocellulosic material, but is especially suitable for small, soft samples.

Embedded vertical dual of silver nanoparticles for improved ZnO/Si heterojunction solar cells

Science.gov (United States)

Shokeen, Poonam; Jain, Amit; Kapoor, Avinashi

2017-10-01

A ZnO/Si heterojunction solar cell is studied with plasmonic nanoparticles embedded in the active layer. Two layers of silver nanoparticles are embedded in the ZnO layer. The effect of various parameters such as vertical-interparticle distance, horizontal-interparticle distance, relative dimensions of nanoparticles, and order of particle diameters are discussed in detail. Finite-difference time-domain studies suggest that particle dimensions of the top layer of silver nanoparticles should be less than the dimensions of the underneath layer of silver nanoparticles. The resulting structure acquires the benefits of each layer and improves the device performance over a broad spectrum. The dielectric separation of plasmonic layers is observed to be an important factor in favorable plasmonic response. Electric field diagrams are used to study the scattering of an incident field by proposed structure. Results are encouraging and suggest more concerted studies of multilayer plasmonic structures.

CD44 standard and CD44v10 isoform expression on leukemia cells distinctly influences niche embedding of hematopoietic stem cells.

Science.gov (United States)

Erb, Ulrike; Megaptche, Amelie Pajip; Gu, Xiaoyu; Büchler, Markus W; Zöller, Margot

2014-03-31

A blockade of CD44 is considered a therapeutic option for the elimination of leukemia initiating cells. However, anti-panCD44 can interfere with hematopoiesis. Therefore we explored, whether a CD44 variant isoform (CD44v)-specific antibody can inhibit leukemia growth without attacking hematopoiesis. As a model we used CD44v10 transfected EL4 thymoma cells (EL4-v10). The therapeutic efficacy of anti-panCD44 and anti-CD44v10 was evaluated after intravenous application of EL4/EL4-v10. Ex vivo and in vitro studies evaluated the impact of anti-panCD44 and anti-CD44v10 as well as of EL4 and EL4-v10 on hematopoietic stem cells (HSC) in cocultures with bone marrow stroma cells with a focus on adhesion, migration, cell cycle progression and apoptosis resistance. Intravenously injected EL4-v10 grow in bone marrow and spleen. Anti-panCD44 and, more pronounced anti-CD44v10 prolong the survival time. The higher efficacy of anti-CD44v10 compared to anti-panCD44 does not rely on stronger antibody-dependent cellular cytotoxicity or on promoting EL4-v10 apoptosis. Instead, EL4 compete with HSC niche embedding. This has consequences on quiescence and apoptosis-protecting signals provided by the stroma. Anti-panCD44, too, more efficiently affected embedding of HSC than of EL4 in the bone marrow stroma. EL4-v10, by catching osteopontin, migrated on bone marrow stroma and did not or weakly interfere with HSC adhesion. Anti-CD44v10, too, did not affect the HSC--bone marrow stroma crosstalk. The therapeutic effect of anti-panCD44 and anti-CD44v10 is based on stimulation of antibody-dependent cellular cytotoxicity. The superiority of anti-CD44v10 is partly due to blocking CD44v10-stimulated osteopontin expression that could drive HSC out of the niche. However, the main reason for the superiority of anti-CD44v10 relies on neither EL4-v10 nor anti-CD44v10 severely interfering with HSC--stroma cell interactions that, on the other hand, are affected by EL4 and anti-panCD44. Anti-panCD44

A ferroelectric memory technology for embedded LSI

CERN Document Server

Kunio, T

1999-01-01

We have developed an FeRAM (Ferroelectric Random Access Memory) embedded smart card LSI by using double metal 0.8- mu m CMOS technology. The smart-card has a 256-byte FeRAM macro and an 8-bit microcontroller. The FeRAM macro has the $9 performance of 10/sup 8/ endurance cycles and is half the size of an EEPROM macro. We have also developed a new CMVP (Capacitor on Meta/Via Stacked Plug) cell for an advanced FeRAM embedded LSI by using 0.25- mu m CMOS technology. $9 The ferroelectric capacitors of this cell are fabricated after the multiple interconnect is formed, and a cell area of 3.2 mu m/sup 2/ is obtained. (8 refs).

Microbial Habitability and Pleistocene Aridification of the Asian Interior.

Science.gov (United States)

Wang, Jiuyi; Lowenstein, Tim K; Fang, Xiaomin

2016-06-01

Fluid inclusions trapped in ancient halite can contain a community of halophilic prokaryotes and eukaryotes that inhabited the surface brines from which the halite formed. Long-term survival of bacteria and archaea and preservation of DNA have been reported from halite, but little is known about the distribution of microbes in buried evaporites. Here we report the discovery of prokaryotes and single-celled algae in fluid inclusions in Pleistocene halite, up to 2.26 Ma in age, from the Qaidam Basin, China. We show that water activity (aw), a measure of water availability and an environmental control on biological habitability in surface brines, is also related to microbe entrapment in fluid inclusions. The aw of Qaidam Basin brines progressively decreased over the last ∼1 million years, driven by aridification of the Asian interior, which led to decreased precipitation and water inflow and heightened evaporation rates. These changes in water balance produced highly concentrated brines, which reduced the habitability of surface lakes and decreased the number of microbes trapped in halite. By 0.13 Ma, the aw of surface brines approached the limits tolerated by halophilic prokaryotes and algae. These results show the response of microbial ecosystems to climate change in an extreme environment, which will guide future studies exploring deep life on Earth and elsewhere in the Solar System. Halite fluid inclusions-Ancient microbes-Water activity-Qaidam Basin-Pleistocene aridification. Astrobiology 16, 379-388.

Embedded Leverage

DEFF Research Database (Denmark)

Frazzini, Andrea; Heje Pedersen, Lasse

find that asset classes with embedded leverage offer low risk-adjusted returns and, in the cross-section, higher embedded leverage is associated with lower returns. A portfolio which is long low-embedded-leverage securities and short high-embedded-leverage securities earns large abnormal returns...

Embedding potentials for excited states of embedded species

International Nuclear Information System (INIS)

Wesolowski, Tomasz A.

2014-01-01

Frozen-Density-Embedding Theory (FDET) is a formalism to obtain the upper bound of the ground-state energy of the total system and the corresponding embedded wavefunction by means of Euler-Lagrange equations [T. A. Wesolowski, Phys. Rev. A 77(1), 012504 (2008)]. FDET provides the expression for the embedding potential as a functional of the electron density of the embedded species, electron density of the environment, and the field generated by other charges in the environment. Under certain conditions, FDET leads to the exact ground-state energy and density of the whole system. Following Perdew-Levy theorem on stationary states of the ground-state energy functional, the other-than-ground-state stationary states of the FDET energy functional correspond to excited states. In the present work, we analyze such use of other-than-ground-state embedded wavefunctions obtained in practical calculations, i.e., when the FDET embedding potential is approximated. Three computational approaches based on FDET, that assure self-consistent excitation energy and embedded wavefunction dealing with the issue of orthogonality of embedded wavefunctions for different states in a different manner, are proposed and discussed

Mechanical stratification of autochthonous salt: Implications from basin-scale numerical models of rifted margin salt tectonics

Science.gov (United States)

Ings, Steven; Albertz, Markus

2014-05-01

Deformation of salt and sediments owing to the flow of weak evaporites is a common phenomenon in sedimentary basins worldwide, and the resulting structures and thermal regimes have a significant impact on hydrocarbon exploration. Evaporite sequences ('salt') of significant thickness (e.g., >1km) are typically deposited in many cycles of seawater inundation and evaporation in restricted basins resulting in layered autochthonous evaporite packages. However, analogue and numerical models of salt tectonics typically treat salt as a homogeneous viscous material, often with properties of halite, the weakest evaporite. In this study, we present results of two-dimensional plane-strain numerical experiments designed to illustrate the effects of variable evaporite viscosity and embedded frictional-plastic ('brittle') sediment layers on the style of salt flow and associated deformation of the sedimentary overburden. Evaporite viscosity is a first-order control on salt flow rate and the style of overburden deformation. Near-complete evacuation of low-viscosity salt occurs beneath expulsion basins, whereas significant salt is trapped when viscosity is high. Embedded frictional-plastic sediment layers (with finite yield strength) partition salt flow and develop transient contractional structures (folds, thrust faults, and folded faults) in a seaward salt-squeeze flow regime. Multiple internal sediment layers reduce the overall seaward salt flow during sediment aggradation, leaving more salt behind to be re-mobilized during subsequent progradation. This produces more seaward extensive allochthonous salt sheets. If there is a density difference between the embedded layers and the surrounding salt, then the embedded layers 'fractionate' during deformation and either float to the surface or sink to the bottom (depending on density), creating a thick zone of pure halite. Such a process of 'buoyancy fractionation' may partially explain the apparent paradox of layered salt in

Trusted computing for embedded systems

CERN Document Server

Soudris, Dimitrios; Anagnostopoulos, Iraklis

2015-01-01

This book describes the state-of-the-art in trusted computing for embedded systems. It shows how a variety of security and trusted computing problems are addressed currently and what solutions are expected to emerge in the coming years. The discussion focuses on attacks aimed at hardware and software for embedded systems, and the authors describe specific solutions to create security features. Case studies are used to present new techniques designed as industrial security solutions. Coverage includes development of tamper resistant hardware and firmware mechanisms for lightweight embedded devices, as well as those serving as security anchors for embedded platforms required by applications such as smart power grids, smart networked and home appliances, environmental and infrastructure sensor networks, etc. ·         Enables readers to address a variety of security threats to embedded hardware and software; ·         Describes design of secure wireless sensor networks, to address secure authen...

Regulation of fibrochondrogenesis of mesenchymal stem cells in an integrated microfluidic platform embedded with biomimetic nanofibrous scaffolds.

Directory of Open Access Journals (Sweden)

Weiliang Zhong

Full Text Available In native fibrocartilage, mechanotransduction allows the cells to perceive the physical microenvironment not only through topographical cues from the extracellular matrix, but also through mechanical cues, such as interstitial flow. To create a microenvironment that simultaneously integrates nanotopography and flow stimulus, we developed a biomimetic microfluidic device embedded with aligned nanofibers to contain microchambers of different angles, which enabled the flow direction to form different angles with the fibers. Using this device, we investigated the effects of microfluidic and nanotopographical environment on the morphology and fibrochondrogenesis of mesenchymal stem cells (MSCs and the involvement of RhoA/ROCK pathway and Yes-associated protein (YAP/transcriptional co-activator with PDZ-binding motif (TAZ. The results showed that the flow direction perpendicular to aligned nanofibers was conducive to fibrochondrogenesis of MSCs. In addition, ROCK inhibitor and knockdown of YAP/TAZ disrupted fibrochondrogenic differentiation of MSCs. In conclusion, our data suggest the crucial role of mechanotransduction in regulating fibrochondrogenic differentiation of MSCs, which may be mediated by RhoA/ROCK pathway and YAP/TAZ.

Immunohistochemical comparison of markers for wound healing on plastic-embedded and frozen mucosal tissue.

Science.gov (United States)

Mai, Ronald; Gedrange, Tomasz; Leonhardt, Henry; Sievers, Nicole; Lauer, Günter

2009-01-01

Immunohistologic investigations of wound healing in human oral mucosa require specific cell biological markers as well as consecutive small biopsies. Small specimens are ideally embedded in plastic (methylmethacrylate, MMA) resin due to their miniature size. This limits the use of antibodies for these markers. In this immunohistochemical study, the distribution of wound healing markers, e.g. cytokeratin (CK), laminin, collagen IV, vimentin, vinculin and fibronectin, were compared between semithin sections of plastic-embedded tissue and frozen sections of mucosal tissue in order to assess their use for future investigations. The antibodies against laminin, collagen IV and CK 1/2/10/11, 5/6, 13, 14, 17, 19 gave comparable staining patterns on cryostat sections of attached mucosa and on semithin sections of MMA-embedded attached mucosa. In the epithelial cell layers, the following distribution of CK immunostaining was observed: The basal cell layer was positive for CK 5/6, CK 14 and CK 19; the intermediate cell layer for CK 13, CK 17 and CK 1/2/10/11, and the superficial cell layer for CK 13 and CK 1/2/10/11. For most of these antibodies, enzyme digestion with 0.1% trypsin was adequate for demasking the antigens, except for anti-CK 14, anti-CK 17 and anti-laminin; predigestion with 0.4% pepsin in 0.01 N HCl gave similar staining results. The antibodies against vimentin, vinculin, fibronectin and CK 4 showed no affinity or a reciprocal reaction on the semithin sections. Therefore, the antibodies against CK 1/2/10/11; 5/6; 13; 14; 17, and 19, as well as the basement proteins laminin and collagen IV are deemed markers suitable on semithin sections of plastic-embedded attached oral mucosa. (c) 2008 S. Karger AG, Basel.

Embedded Systems

Indian Academy of Sciences (India)

Embedded system, micro-con- troller ... Embedded systems differ from general purpose computers in many ... Low cost: As embedded systems are extensively used in con- .... operating systems for the desktop computers where scheduling.

Limit for the Survivability from Potassium Decay of Bacterial Spores in Halite Fluid Inclusions

Science.gov (United States)

Kminek, G.; Bada, J. L.

2001-12-01

Vreeland et al.1 recently claimed to have isolated and cultured a viable spore forming halotolerant bacterium from a 250 million year old brine inclusion present in a salt crystal from the Salado formation. An earlier report suggested that viable bacterial spores could be revived from samples obtained from insects entombed in 25-40 million year old Dominican amber2. On the bases of these reports, Parkes3 raised the question of whether bacterial spores under some conditions might be effectively immortal. Sporulation, induced by an adverse change in the environmental conditions, is able to stabilize the DNA primarily against hydrolytic depurination for extended periods of time4. However, the organism is still exposed to ionizing radiation from the environment. Dormant spores have a reduced sensitivity to ionizing radiation per se, but unlike active organisms are unable to repair DNA damage encountered during long-term exposure to ionizing radiation. The accumulated damage may overwhelm any repair mechanism that starts in the early stage of spore germination5. The main radionuclide in a halite fluid inclusion is 40K, which accounts for 0.0117% of natural potassium. 40K decays via beta decay to 40Ca and via electron capture to 40Ar, releasing a primary gamma-ray. About 83.3 % of the beta's emitted are in the energy range of 0.3-1.3 MeV. We assume 7 g/l for an average concentration of natural potassium in a halite fluid inclusion, which means that the amount of 40K in a 10 μ l fluid inclusion is 8.19 ng. We have chosen a 10 μ l because this volume is typical of that used to obtain chemical data and in the attempts to extract bacteria. Less than a percent of the gamma decay energy is absorbed in a fluid inclusion of 10 μ l. Thus, we will not take the gamma decay energy into account for the further discussion. Almost all the beta energy is absorbed in the fluid inclusion. The total decay energy absorbed in a time period of 250 million years is about 87 kGy. The most

Embedded Disposable Functionalized Electrochemical Biosensor with a 3D-Printed Flow Cell for Detection of Hepatic Oval Cells (HOCs

Directory of Open Access Journals (Sweden)

Samar Damiati

2018-02-01

Full Text Available Hepatic oval cells (HOCs are considered the progeny of the intrahepatic stem cells that are found in a small population in the liver after hepatocyte proliferation is inhibited. Due to their small number, isolation and capture of these cells constitute a challenging task for immunosensor technology. This work describes the development of a 3D-printed continuous flow system and exploits disposable screen-printed electrodes for the rapid detection of HOCs that over-express the OV6 marker on their membrane. Multiwall carbon nanotube (MWCNT electrodes have a chitosan film that serves as a scaffold for the immobilization of oval cell marker antibodies (anti-OV6-Ab, which enhance the sensitivity of the biomarker and makes the designed sensor specific for oval cells. The developed sensor can be easily embedded into the 3D-printed flow cell to allow cells to be exposed continuously to the functionalized surface. The continuous flow is intended to increase capture of most of the target cells in the specimen. Contact angle measurements were performed to characterize the nature and quality of the modified sensor surface, and electrochemical measurements (cyclic voltammetry (CV and square wave voltammetry (SWV were performed to confirm the efficiency and selectivity of the fabricated sensor to detect HOCs. The proposed method is valuable for capturing rare cells and could provide an effective tool for cancer diagnosis and detection.

Embedded Disposable Functionalized Electrochemical Biosensor with a 3D-Printed Flow Cell for Detection of Hepatic Oval Cells (HOCs)

Science.gov (United States)

Peacock, Martin; Leonhardt, Stefan; Damiati, Laila; Baghdadi, Mohammed A.; Schuster, Bernhard

2018-01-01

Hepatic oval cells (HOCs) are considered the progeny of the intrahepatic stem cells that are found in a small population in the liver after hepatocyte proliferation is inhibited. Due to their small number, isolation and capture of these cells constitute a challenging task for immunosensor technology. This work describes the development of a 3D-printed continuous flow system and exploits disposable screen-printed electrodes for the rapid detection of HOCs that over-express the OV6 marker on their membrane. Multiwall carbon nanotube (MWCNT) electrodes have a chitosan film that serves as a scaffold for the immobilization of oval cell marker antibodies (anti-OV6-Ab), which enhance the sensitivity of the biomarker and makes the designed sensor specific for oval cells. The developed sensor can be easily embedded into the 3D-printed flow cell to allow cells to be exposed continuously to the functionalized surface. The continuous flow is intended to increase capture of most of the target cells in the specimen. Contact angle measurements were performed to characterize the nature and quality of the modified sensor surface, and electrochemical measurements (cyclic voltammetry (CV) and square wave voltammetry (SWV)) were performed to confirm the efficiency and selectivity of the fabricated sensor to detect HOCs. The proposed method is valuable for capturing rare cells and could provide an effective tool for cancer diagnosis and detection. PMID:29443890

Embedded Disposable Functionalized Electrochemical Biosensor with a 3D-Printed Flow Cell for Detection of Hepatic Oval Cells (HOCs).

Science.gov (United States)

Damiati, Samar; Peacock, Martin; Leonhardt, Stefan; Damiati, Laila; Baghdadi, Mohammed A; Becker, Holger; Kodzius, Rimantas; Schuster, Bernhard

2018-02-14

Hepatic oval cells (HOCs) are considered the progeny of the intrahepatic stem cells that are found in a small population in the liver after hepatocyte proliferation is inhibited. Due to their small number, isolation and capture of these cells constitute a challenging task for immunosensor technology. This work describes the development of a 3D-printed continuous flow system and exploits disposable screen-printed electrodes for the rapid detection of HOCs that over-express the OV6 marker on their membrane. Multiwall carbon nanotube (MWCNT) electrodes have a chitosan film that serves as a scaffold for the immobilization of oval cell marker antibodies (anti-OV6-Ab), which enhance the sensitivity of the biomarker and makes the designed sensor specific for oval cells. The developed sensor can be easily embedded into the 3D-printed flow cell to allow cells to be exposed continuously to the functionalized surface. The continuous flow is intended to increase capture of most of the target cells in the specimen. Contact angle measurements were performed to characterize the nature and quality of the modified sensor surface, and electrochemical measurements (cyclic voltammetry (CV) and square wave voltammetry (SWV)) were performed to confirm the efficiency and selectivity of the fabricated sensor to detect HOCs. The proposed method is valuable for capturing rare cells and could provide an effective tool for cancer diagnosis and detection.

Regeneration of hyaline cartilage promoted by xenogeneic mesenchymal stromal cells embedded within elastin-like recombinamer-based bioactive hydrogels.

Science.gov (United States)

Pescador, David; Ibáñez-Fonseca, Arturo; Sánchez-Guijo, Fermín; Briñón, Jesús G; Arias, Francisco Javier; Muntión, Sandra; Hernández, Cristina; Girotti, Alessandra; Alonso, Matilde; Del Cañizo, María Consuelo; Rodríguez-Cabello, José Carlos; Blanco, Juan Francisco

2017-08-01

Over the last decades, novel therapeutic tools for osteochondral regeneration have arisen from the combination of mesenchymal stromal cells (MSCs) and highly specialized smart biomaterials, such as hydrogel-forming elastin-like recombinamers (ELRs), which could serve as cell-carriers. Herein, we evaluate the delivery of xenogeneic human MSCs (hMSCs) within an injectable ELR-based hydrogel carrier for osteochondral regeneration in rabbits. First, a critical-size osteochondral defect was created in the femora of the animals and subsequently filled with the ELR-based hydrogel alone or with embedded hMSCs. Regeneration outcomes were evaluated after three months by gross assessment, magnetic resonance imaging and computed tomography, showing complete filling of the defect and the de novo formation of hyaline-like cartilage and subchondral bone in the hMSC-treated knees. Furthermore, histological sectioning and staining of every sample confirmed regeneration of the full cartilage thickness and early subchondral bone repair, which was more similar to the native cartilage in the case of the cell-loaded ELR-based hydrogel. Overall histological differences between the two groups were assessed semi-quantitatively using the Wakitani scale and found to be statistically significant (p hyaline cartilage in osteochondral lesions.

Conceptualizing Embedded Configuration

DEFF Research Database (Denmark)

Oddsson, Gudmundur Valur; Hvam, Lars; Lysgaard, Ole

2006-01-01

and services. The general idea can be named embedded configuration. In this article we intend to conceptualize embedded configuration, what it is and is not. The difference between embedded configuration, sales configuration and embedded software is explained. We will look at what is needed to make embedded...... configuration systems. That will include requirements to product modelling techniques. An example with consumer electronics will illuminate the elements of embedded configuration in settings that most can relate to. The question of where embedded configuration would be relevant is discussed, and the current...

A 4-kbit low-cost antifuse one-time programmable memory macro for embedded applications

International Nuclear Information System (INIS)

Li Xian; Zhong Huicai; Jia Cheng; Li Xin

2014-01-01

A 4-kbit low-cost one-time programmable (OTP) memory macro for embedded applications is designed and implemented in a 0.18-μm standard CMOS process. The area of the proposed 1.5 transistor (1.5T) OTP cell is 2.13 μm 2 , which is a 49.3% size reduction compared to the previously reported cells. The 1.5T cell is fabricated and measured and shows a large programming window without any disturbance. A novel high voltage switch (HVSW) circuit is also proposed to make sure the OTP macro, implemented in a standard CMOS process, works reliably with the high program voltage. The OTP macro is embedded in negative radio frequency identification (RFID) tags. The full chip size, including the analog front-end, digital controller and the 4-kbit OTP macro, is 600 × 600 μm 2 . The 4-kbit OTP macro only consumes 200 × 260 μm 2 . The measurement shows a 100% program yield by adjusting the program time and has obvious advantages in the core area and power consumption compared to the reported 3T and 2T OTP cores. (semiconductor integrated circuits)

Graphene Films Show Stable Cell Attachment and Biocompatibility with Electrogenic Primary Cardiac Cells

OpenAIRE

Kim, Taeyong; Kahng, Yung Ho; Lee, Takhee; Lee, Kwanghee; Kim, Do Han

2013-01-01

Graphene has attracted substantial attention due to its advantageous materialistic applicability. In the present study, we tested the biocompatibility of graphene films synthesized by chemical vapor deposition with electrogenic primary adult cardiac cells (cardiomyocytes) by measuring the cell properties such as cell attachment, survival, contractility and calcium transients. The results show that the graphene films showed stable cell attachment and excellent biocompatibility with the electro...

Properties of Retinal Precursor Cells Grown on Vertically Aligned Multiwalled Carbon Nanotubes Generated for the Modification of Retinal Implant-Embedded Microelectrode Arrays.

Science.gov (United States)

Johnen, Sandra; Meißner, Frank; Krug, Mario; Baltz, Thomas; Endler, Ingolf; Mokwa, Wilfried; Walter, Peter

2016-01-01

Background. To analyze the biocompatibility of vertically aligned multiwalled carbon nanotubes (MWCNT), used as nanomodification to optimize the properties of prostheses-embedded microelectrodes that induce electrical stimulation of surviving retinal cells. Methods. MWCNT were synthesized on silicon wafers. Their growth was achieved by iron particles (Fe) or mixtures of iron-platinum (Fe-Pt) and iron-titanium (Fe-Ti) acting as catalysts. Viability, growth, adhesion, and gene expression of L-929 and retinal precursor (R28) cells were analyzed after nondirect and direct contact. Results. Nondirect contact had almost no influence on cell growth, as measured in comparison to reference materials with defined levels of cytotoxicity. Both cell types exhibited good proliferation properties on each MWCNT-coated wafer. Viability ranged from 95.9 to 99.8%, in which better survival was observed for nonfunctionalized MWCNT generated with the Fe-Pt and Fe-Ti catalyst mixtures. R28 cells grown on the MWCNT-coated wafers showed a decreased gene expression associated with neural and glial properties. Expression of the cell cycle-related genes CCNC, MYC, and TP53 was slightly downregulated. Cultivation on plasma-treated MWCNT did not lead to additional changes. Conclusions. All tested MWCNT-covered slices showed good biocompatibility profiles, confirming that this nanotechnology is a promising tool to improve prostheses bearing electrodes which connect with retinal tissue.

Properties of Retinal Precursor Cells Grown on Vertically Aligned Multiwalled Carbon Nanotubes Generated for the Modification of Retinal Implant-Embedded Microelectrode Arrays

Directory of Open Access Journals (Sweden)

Sandra Johnen

2016-01-01

Full Text Available Background. To analyze the biocompatibility of vertically aligned multiwalled carbon nanotubes (MWCNT, used as nanomodification to optimize the properties of prostheses-embedded microelectrodes that induce electrical stimulation of surviving retinal cells. Methods. MWCNT were synthesized on silicon wafers. Their growth was achieved by iron particles (Fe or mixtures of iron-platinum (Fe-Pt and iron-titanium (Fe-Ti acting as catalysts. Viability, growth, adhesion, and gene expression of L-929 and retinal precursor (R28 cells were analyzed after nondirect and direct contact. Results. Nondirect contact had almost no influence on cell growth, as measured in comparison to reference materials with defined levels of cytotoxicity. Both cell types exhibited good proliferation properties on each MWCNT-coated wafer. Viability ranged from 95.9 to 99.8%, in which better survival was observed for nonfunctionalized MWCNT generated with the Fe-Pt and Fe-Ti catalyst mixtures. R28 cells grown on the MWCNT-coated wafers showed a decreased gene expression associated with neural and glial properties. Expression of the cell cycle-related genes CCNC, MYC, and TP53 was slightly downregulated. Cultivation on plasma-treated MWCNT did not lead to additional changes. Conclusions. All tested MWCNT-covered slices showed good biocompatibility profiles, confirming that this nanotechnology is a promising tool to improve prostheses bearing electrodes which connect with retinal tissue.

The art of designing embedded systems

CERN Document Server

Ganssle, Jack G

2000-01-01

Art of Designing Embedded Systems is apart primer and part reference, aimed at practicing embedded engineers, whether working on the code or the hardware design. Embedded systems suffer from a chaotic, ad hoc development process. This books lays out a very simple seven-step plan to get firmware development under control. There are no formal methodologies to master; the ideas are immediately useful. Most designers are unaware that code complexity grows faster than code size. This book shows a number of ways to linearize the complexity/size curve and get products out faster

Cell-Averaged discretization for incompressible Navier-Stokes with embedded boundaries and locally refined Cartesian meshes: a high-order finite volume approach

Science.gov (United States)

Bhalla, Amneet Pal Singh; Johansen, Hans; Graves, Dan; Martin, Dan; Colella, Phillip; Applied Numerical Algorithms Group Team

2017-11-01

We present a consistent cell-averaged discretization for incompressible Navier-Stokes equations on complex domains using embedded boundaries. The embedded boundary is allowed to freely cut the locally-refined background Cartesian grid. Implicit-function representation is used for the embedded boundary, which allows us to convert the required geometric moments in the Taylor series expansion (upto arbitrary order) of polynomials into an algebraic problem in lower dimensions. The computed geometric moments are then used to construct stencils for various operators like the Laplacian, divergence, gradient, etc., by solving a least-squares system locally. We also construct the inter-level data-transfer operators like prolongation and restriction for multi grid solvers using the same least-squares system approach. This allows us to retain high-order of accuracy near coarse-fine interface and near embedded boundaries. Canonical problems like Taylor-Green vortex flow and flow past bluff bodies will be presented to demonstrate the proposed method. U.S. Department of Energy, Office of Science, ASCR (Award Number DE-AC02-05CH11231).

Processing large-diameter poly(L-lactic acid) microfiber mesh/mesenchymal stromal cell constructs via resin embedding: an efficient histologic method

International Nuclear Information System (INIS)

D’Alessandro, Delfo; Danti, Serena; Pertici, Gianni; Moscato, Stefania; Metelli, Maria Rita; Petrini, Mario; Danti, Sabrina; Berrettini, Stefano; Nesti, Claudia

2014-01-01

In this study, we performed a complete histologic analysis of constructs based on large diameter ( > 100 μm) poly-L-lactic acid (PLLA) microfibers obtained via dry-wet spinning and rat Mesenchymal Stromal Cells (rMSCs) differentiated towards the osteogenic lineage, using acrylic resin embedding. In many synthetic polymer-based microfiber meshes, ex post processability of fiber/cell constructs for histologic analysis may face deterring difficulties, leading to an incomplete investigation of the potential of these scaffolds. Indeed, while polymeric nanofiber (fiber diameter = tens of nanometers)/cell constructs can usually be embedded in common histologic media and easily sectioned, preserving the material structure and the antigenic reactivity, histologic analysis of large polymeric microfiber/cell constructs in the literature is really scant. This affects microfiber scaffolds based on FDA-approved and widely used polymers such as PLLA and its copolymers. Indeed, for such constructs, especially those with fiber diameter and fiber interspace much larger than cell size, standard histologic processing is usually inefficient due to inhomogeneous hardness and lack of cohesion between the synthetic and the biological phases under sectioning. In this study, the microfiber/MSC constructs were embedded in acrylic resin and the staining/reaction procedures were calibrated to demonstrate the possibility of successfully employing histologic methods in tissue engineering studies even in such difficult cases. We histologically investigated the main osteogenic markers and extracellular matrix molecules, such as alkaline phosphatase, osteopontin, osteocalcin, TGF-β1, Runx2, Collagen type I and the presence of amorphous, fibrillar and mineralized matrix. Biochemical tests were employed to confirm our findings. This protocol permitted efficient sectioning of the treated constructs and good penetration of the histologic reagents, thus allowing distribution and expression of

Measurement of in-plane elasticity of live cell layers using a pressure sensor embedded microfluidic device

Science.gov (United States)

Lin, Chien-Han; Wang, Chien-Kai; Chen, Yu-An; Peng, Chien-Chung; Liao, Wei-Hao; Tung, Yi-Chung

2016-11-01

In various physiological activities, cells experience stresses along their in-plane direction when facing substrate deformation. Capability of continuous monitoring elasticity of live cell layers during a period is highly desired to investigate cell property variation during various transformations under normal or disease states. This paper reports time-lapsed measurement of live cell layer in-plane elasticity using a pressure sensor embedded microfluidic device. The sensor converts pressure-induced deformation of a flexible membrane to electrical signals. When cells are cultured on top of the membrane, flexural rigidity of the composite membrane increases and further changes the output electrical signals. In the experiments, human embryonic lung fibroblast (MRC-5) cells are cultured and analyzed to estimate the in-plane elasticity. In addition, the cells are treated with a growth factor to simulate lung fibrosis to study the effects of cell transformation on the elasticity variation. For comparison, elasticity measurement on the cells by atomic force microscopy (AFM) is also performed. The experimental results confirm highly anisotropic configuration and material properties of cells. Furthermore, the in-plane elasticity can be monitored during the cell transformation after the growth factor stimulation. Consequently, the developed microfluidic device provides a powerful tool to study physical properties of cells for fundamental biophysics and biomedical researches.

Costs and benefits of embedded generation

International Nuclear Information System (INIS)

1999-11-01

This project sought to evaluate the costs and benefits of embedded generation in the light of the UK government's consultation paper on the future of green generation, the government's aim to increase the levels of generation from renewable energy sources and cogeneration, the current Review of the Electricity Trading Arrangements, and the form of the Distribution Price Control. Definitions are given for embedded, centrally dispatched, and pooled generation, and licensed suppliers, and commercial and economic values. The commercial and economic value of embedded generation is examined in terms of generation prices, costs to electrical suppliers, losses (electrical, transmission, distribution), and effects on the national grid and distribution network. Diagrams showing the cost elements of trading through the Pool and the elements that are avoided by non-Pool embedded generator trading are presented

Automated Analysis of Protein Expression and Gene Amplification within the Same Cells of Paraffin-Embedded Tumour Tissue

Directory of Open Access Journals (Sweden)

Timo Gaiser

2010-01-01

Full Text Available Background: The simultaneous detection of protein expression and gene copy number changes in patient samples, like paraffin-embedded tissue sections, is challenging since the procedures of immunohistochemistry (IHC and Fluorescence in situ Hybridization (FISH negatively influence each other which often results in suboptimal staining. Therefore, we developed a novel automated algorithm based on relocation which allows subsequent detection of protein content and gene copy number changes within the same cell.

Embedded Web Technology: Applying World Wide Web Standards to Embedded Systems

Science.gov (United States)

Ponyik, Joseph G.; York, David W.

2002-01-01

Embedded Systems have traditionally been developed in a highly customized manner. The user interface hardware and software along with the interface to the embedded system are typically unique to the system for which they are built, resulting in extra cost to the system in terms of development time and maintenance effort. World Wide Web standards have been developed in the passed ten years with the goal of allowing servers and clients to intemperate seamlessly. The client and server systems can consist of differing hardware and software platforms but the World Wide Web standards allow them to interface without knowing about the details of system at the other end of the interface. Embedded Web Technology is the merging of Embedded Systems with the World Wide Web. Embedded Web Technology decreases the cost of developing and maintaining the user interface by allowing the user to interface to the embedded system through a web browser running on a standard personal computer. Embedded Web Technology can also be used to simplify an Embedded System's internal network.

Capacitance spectroscopy on n-type GaNAs/GaAs embedded quantum structure solar cells

Science.gov (United States)

Venter, Danielle; Bollmann, Joachim; Elborg, Martin; Botha, J. R.; Venter, André

2018-04-01

In this study, both deep level transient spectroscopy (DLTS) and admittance spectroscopy (AS) have been used to study the properties of electrically active deep level centers present in GaNAs/GaAs quantum wells (QWs) embedded in p-i-n solar cells. The structures were grown by molecular beam epitaxy (MBE). In particular, the electrical properties of samples with Si (n-type) doping of the QWs were investigated. DLTS revealed four deep level centers in the material, whereas only three were detected by AS. NextNano++ simulation software was used to model the sample band-diagrams to provide reasoning for the origin of the signals produced by both techniques.

A novel sample preparation method to avoid influence of embedding medium during nano-indentation

Science.gov (United States)

Yujie Meng; Siqun Wang; Zhiyong Cai; Timothy M. Young; Guanben Du; Yanjun Li

2012-01-01

The effect of the embedding medium on the nano-indentation measurements of lignocellulosic materials was investigated experimentally using nano-indentation. Both the reduced elastic modulus and the hardness of nonembedded cell walls were found to be lower than those of the embedded samples, proving that the embedding medium used for specimen preparation on cellulosic...

Embedded, everywhere: a research agenda for networked systems of embedded computers

National Research Council Canada - National Science Library

Committee on Networked Systems of Embedded Computers; National Research Council Staff; Division on Engineering and Physical Sciences; Computer Science and Telecommunications Board; National Academy of Sciences

2001-01-01

.... Embedded, Everywhere explores the potential of networked systems of embedded computers and the research challenges arising from embedding computation and communications technology into a wide variety of applicationsâ...

Teaching Embedded System Concepts for Technological Literacy

Science.gov (United States)

Winzker, M.; Schwandt, A.

2011-01-01

A basic understanding of technology is recognized as important knowledge even for students not connected with engineering and computer science. This paper shows that embedded system concepts can be taught in a technological literacy course. An embedded system teaching block that has been used in an electronics module for non-engineers is…

ROPE: Recoverable Order-Preserving Embedding of Natural Language

Energy Technology Data Exchange (ETDEWEB)

Widemann, David P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wang, Eric X. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Thiagarajan, Jayaraman J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2016-02-11

We present a novel Recoverable Order-Preserving Embedding (ROPE) of natural language. ROPE maps natural language passages from sparse concatenated one-hot representations to distributed vector representations of predetermined fixed length. We use Euclidean distance to return search results that are both grammatically and semantically similar. ROPE is based on a series of random projections of distributed word embeddings. We show that our technique typically forms a dictionary with sufficient incoherence such that sparse recovery of the original text is possible. We then show how our embedding allows for efficient and meaningful natural search and retrieval on Microsoft’s COCO dataset and the IMDB Movie Review dataset.

Preparation of a non-woven poly(ε-caprolactone) fabric with partially embedded apatite surface for bone tissue engineering applications by partial surface melting of poly(ε-caprolactone) fibers.

Science.gov (United States)

Kim, In Ae; Rhee, Sang-Hoon

2017-07-01

This article describes a novel method for the preparation of a biodegradable non-woven poly(ε-caprolactone) fabric with a partially embedded apatite surface designed for application as a scaffold material for bone tissue engineering. The non-woven poly(ε-caprolactone) fabric was generated by the electro-spinning technique and then apatite was coated in simulated body fluid after coating the PVA solution containing CaCl 2 ·2H 2 O. The apatite crystals were partially embedded or fully embedded into the thermoplastic poly(ε-caprolactone) fibers by controlling the degree of poly(ε-caprolactone) fiber surface melting in a convection oven. Identical apatite-coated poly(ε-caprolactone) fabric that did not undergo heat-treatment was used as a control. The features of the embedded apatite crystals were evaluated by FE-SEM, AFM, EDS, and XRD. The adhesion strengths of the coated apatite layers and the tensile strengths of the apatite coated fabrics with and without heat-treatment were assessed by the tape-test and a universal testing machine, respectively. The degree of water absorbance was assessed by adding a DMEM droplet onto the fabrics. Moreover, cell penetrability was assessed by seeding preosteoblastic MC3T3-E1 cells onto the fabrics and observing the degrees of cell penetration after 1 and 4 weeks by staining nuclei with DAPI. The non-woven poly(ε-caprolactone) fabric with a partially embedded apatite surface showed good water absorbance, cell penetrability, higher apatite adhesion strength, and higher tensile strength compared with the control fabric. These results show that the non-woven poly(ε-caprolactone) fabric with a partially embedded apatite surface is a potential candidate scaffold for bone tissue engineering due to its strong apatite adhesion strength and excellent cell penetrability. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1973-1983, 2017. © 2017 Wiley Periodicals, Inc.

Nuclear Magnetic Shielding Constants from Quantum Mechanical/Molecular Mechanical Calculations Using Polarizable Embedding: Role of the Embedding Potential

DEFF Research Database (Denmark)

Steinmann, Casper; Olsen, Jógvan Magnus Haugaard; Kongsted, Jacob

2014-01-01

We present NMR shielding constants obtained through quantum mechanical/molecular mechanical (QM/MM) embedding calculations. Contrary to previous reports, we show that a relatively small QM region is sufficient, provided that a high-quality embedding potential is used. The calculated averaged NMR...... shielding constants of both acrolein and acetone solvated in water are based on a number of snapshots extracted from classical molecular dynamics simulations. We focus on the carbonyl chromophore in both molecules, which shows large solvation effects, and we study the convergence of shielding constants...

Amniotic Fluid Cells Show Higher Pluripotency-Related Gene Expression Than Allantoic Fluid Cells.

Science.gov (United States)

Kehl, Debora; Generali, Melanie; Görtz, Sabrina; Geering, Diego; Slamecka, Jaroslav; Hoerstrup, Simon P; Bleul, Ulrich; Weber, Benedikt

2017-10-01

Amniotic fluid represents an abundant source of multipotent stem cells, referred as broadly multipotent given their differentiation potential and expression of pluripotency-related genes. However, the origin of this broadly multipotent cellular fraction is not fully understood. Several sources have been proposed so far, including embryonic and extraembryonic tissues. In this regard, the ovine developmental model uniquely allows for direct comparison of fetal fluid-derived cells from two separate fetal fluid cavities, the allantois and the amnion, over the entire duration of gestation. As allantoic fluid mainly collects fetal urine, cells originating from the efferent urinary tract can directly be compared with cells deriving from the extraembryonic amniotic tissues and the fetus. This study shows isolation of cells from the amniotic [ovine amniotic fluid cells (oAFCs)] and allantoic fluid [ovine allantoic fluid cells (oALCs)] in a strictly paired fashion with oAFCs and oALCs derived from the same fetus. Both cell types showed cellular phenotypes comparable to standard mesenchymal stem cells (MSCs), with trilineage differentiation potential, and expression of common ovine MSC markers. However, the expression of MSC markers per single cell was higher in oAFCs as measured by flow cytometry. oAFCs exhibited higher proliferative capacities and showed significantly higher expression of pluripotency-related genes OCT4, STAT3, NANOG, and REX1 by quantitative real-time polymerase chain reaction compared with paired oALCs. No significant decrease of pluripotency-related gene expression was noted over gestation, implying that cells with high differentiation potential may be isolated at the end of pregnancy. In conclusion, this study suggests that cells with highest stem cell characteristics may originate from the fetus itself or the amniotic fetal adnexa rather than from the efferent urinary tract or the allantoic fetal adnexa.

Composable Virtual Platforms for Mixed-Criticality Embedded Systems

NARCIS (Netherlands)

Beyranvand Nejad, A.

2014-01-01

Recent trends show a steady increase towards concurrently executing more and more applications on a single embedded system. Multi-Processor System-on-Chip (MPSoC) architectures are proposed to allow complex design of embedded systems. This is achieved by integrating as many processing resources as

Composable virtual platforms for mixed-criticality embedded systems

NARCIS (Netherlands)

Nejad, A.B.

2014-01-01

Recent trends show a steady increase towards concurrently executing more and more applications on a single embedded system. Multi-Processor System-on-Chip (MPSoC) architectures are proposed to allow complex design of embedded systems. This is achieved by integrating as many processing resources as

Multiple M2-branes and the embedding tensor

NARCIS (Netherlands)

Bergshoeff, Eric A.; de Roo, Mees; Hohm, Olaf

2008-01-01

We show that the Bagger-Lambert theory of multiple M2-branes fits into the general construction of maximally supersymmetric gauge theories using the embedding tensor technique. We apply the embedding tensor technique in order to systematically obtain the consistent gaugings of N = 8 superconformal

When does the Hawking into Unruh mapping for global embeddings work?

International Nuclear Information System (INIS)

Paston, S.A.

2014-01-01

We discuss for which smooth global embeddings of a metric into a Minkowskian spacetime the Hawking into Unruh mapping takes place. There is a series of examples of global embeddings into the Minkowskian spacetime (GEMS) with such mapping for physically interesting metrics. These examples use Fronsdal-type embeddings for which timelines are hyperbolas. In the present work we show that for some new embeddings (non Fronsdal-type) of the Schwarzschild and Reissner-Nordström metrics there is no mapping. We give also the examples of hyperbolic and non hyperbolic type embeddings for the de Sitter metric for which there is no mapping. For the Minkowski metric where there is no Hawking radiation we consider a non trivial embedding with hyperbolic timelines, hence in the ambient space the Unruh effect takes place, and it follows that there is no mapping too. The considered examples show that the meaning of the Hawking into Unruh mapping for global embeddings remains still insufficiently clear and requires further investigations.

Embedded Hyperchaotic Generators: A Comparative Analysis

Science.gov (United States)

Sadoudi, Said; Tanougast, Camel; Azzaz, Mohamad Salah; Dandache, Abbas

In this paper, we present a comparative analysis of FPGA implementation performances, in terms of throughput and resources cost, of five well known autonomous continuous hyperchaotic systems. The goal of this analysis is to identify the embedded hyperchaotic generator which leads to designs with small logic area cost, satisfactory throughput rates, low power consumption and low latency required for embedded applications such as secure digital communications between embedded systems. To implement the four-dimensional (4D) chaotic systems, we use a new structural hardware architecture based on direct VHDL description of the forth order Runge-Kutta method (RK-4). The comparative analysis shows that the hyperchaotic Lorenz generator provides attractive performances compared to that of others. In fact, its hardware implementation requires only 2067 CLB-slices, 36 multipliers and no block RAMs, and achieves a throughput rate of 101.6 Mbps, at the output of the FPGA circuit, at a clock frequency of 25.315 MHz with a low latency time of 316 ns. Consequently, these good implementation performances offer to the embedded hyperchaotic Lorenz generator the advantage of being the best candidate for embedded communications applications.

Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer

Science.gov (United States)

Zhao, Xiaozheng; Huffman, Kenneth E.; Fujimoto, Junya; Canales, Jamie Rodriguez; Girard, Luc; Nie, Guangjun; Heymach, John V.; Wistuba, Igacio I.; Minna, John D.; Yu, Yonghao

2017-10-01

With recent advances in understanding the genomic underpinnings and oncogenic drivers of pathogenesis in different subtypes, it is increasingly clear that proper pretreatment diagnostics are essential for the choice of appropriate treatment options for non-small cell lung cancer (NSCLC). Tumor tissue preservation in optimal cutting temperature (OCT) compound is commonly used in the surgical suite. However, proteins recovered from OCT-embedded specimens pose a challenge for LC-MS/MS experiments, due to the large amounts of polymers present in OCT. Here we present a simple workflow for whole proteome analysis of OCT-embedded NSCLC tissue samples, which involves a simple trichloroacetic acid precipitation step. Comparisons of protein recovery between frozen versus OCT-embedded tissue showed excellent consistency with more than 9200 proteins identified. Using an isobaric labeling strategy, we quantified more than 5400 proteins in tumor versus normal OCT-embedded core needle biopsy samples. Gene ontology analysis indicated that a number of proliferative as well as squamous cell carcinoma (SqCC) marker proteins were overexpressed in the tumor, consistent with the patient's pathology based diagnosis of "poorly differentiated SqCC". Among the most downregulated proteins in the tumor sample, we noted a number of proteins with potential immunomodulatory functions. Finally, interrogation of the aberrantly expressed proteins using a candidate approach and cross-referencing with publicly available databases led to the identification of potential druggable targets in DNA replication and DNA damage repair pathways. We conclude that our approach allows LC-MS/MS proteomic analyses on OCT-embedded lung cancer specimens, opening the way to bring powerful proteomics into the clinic. [Figure not available: see fulltext.

Embedded adhesive connection for laminated glass plates

DEFF Research Database (Denmark)

Hansen, Jens Zangenberg; Poulsen, S.H.; Bagger, A.

2012-01-01

The structural behavior of a new connection design, the embedded adhesive connection, used for laminated glass plates is investigated. The connection consists of an aluminum plate encapsulated in-between two adjacent triple layered laminated glass plates. Fastening between glass and aluminum...... usage in a design situation. The embedded connection shows promising potential as a future fastening system for load-carrying laminated glass plates....

Antimicrobial polycaprolactone/polyethylene glycol embedded lysozyme coatings of Ti implants for osteoblast functional properties in tissue engineering

Science.gov (United States)

Visan, A.; Cristescu, R.; Stefan, N.; Miroiu, M.; Nita, C.; Socol, M.; Florica, C.; Rasoga, O.; Zgura, I.; Sima, L. E.; Chiritoiu, M.; Chifiriuc, M. C.; Holban, A. M.; Mihailescu, I. N.; Socol, G.

2017-09-01

In this study, coatings based on lysozyme embedded into a matrix of polyethylene glycol (PEG) and polycaprolactone (PCL) were fabricated by two different methods (Matrix Assisted Pulsed Laser Evaporation - MAPLE and Dip Coating) for obtaining antimicrobial coatings envisaged for long term medical applications. Coatings with different PEG:PCL compositions (3:1; 1:1; 1:3) were synthesized in order to evaluate the antimicrobial activity of lysozyme embedded into the polymeric matrix. The main surface features, such as roughness and wettability, with impact on the microbial adhesion as well as on the eukaryote cell function were measured. The obtained composite coatings exhibited a significant antibacterial activity against Escherichia coli, Bacillus subtilis, Enterococcus faecalis and Staphylococcus aureus strains. As well, specific blended coatings showed appropriate viability, good spreading and normal cell morphology of SaOs2 human osteoblasts and mesenchymal stem cells (MSCs). These investigations highlight the suitability of biodegradable composites as implant coatings for decreasing the risk of bacterial contamination associated with prosthetic procedures.

Embedded systems handbook

CERN Document Server

Zurawski, Richard

2005-01-01

Embedded systems are nearly ubiquitous, and books on individual topics or components of embedded systems are equally abundant. Unfortunately, for those designers who thirst for knowledge of the big picture of embedded systems there is not a drop to drink. Until now. The Embedded Systems Handbook is an oasis of information, offering a mix of basic and advanced topics, new solutions and technologies arising from the most recent research efforts, and emerging trends to help you stay current in this ever-changing field.With preeminent contributors from leading industrial and academic institutions

Research and application of embedded real-time operating system

Science.gov (United States)

Zhang, Bo

2013-03-01

In this paper, based on the analysis of existing embedded real-time operating system, the architecture of an operating system is designed and implemented. The experimental results show that the design fully complies with the requirements of embedded real-time operating system, can achieve the purposes of reducing the complexity of embedded software design and improving the maintainability, reliability, flexibility. Therefore, this design program has high practical value.

Expanded polyglutamine embedded in the endoplasmic reticulum causes membrane distortion and coincides with Bax insertion

Energy Technology Data Exchange (ETDEWEB)

Ueda, Masashi; Li, Shimo; Itoh, Masanori; Wang, Miao-xing; Hayakawa, Miki; Islam, Saiful; Tana; Nakagawa, Kiyomi [Department of Neurobiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194 (Japan); Chen, Huayue [Department of Anatomy, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194 (Japan); Nakagawa, Toshiyuki, E-mail: tnakagaw@gifu-u.ac.jp [Department of Neurobiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194 (Japan)

2016-05-27

The endoplasmic reticulum (ER) is important in various cellular functions, such as secretary and membrane protein biosynthesis, lipid synthesis, and calcium storage. ER stress, including membrane distortion, is associated with many diseases such as Huntington's disease. In particular, nuclear envelope distortion is related to neuronal cell death associated with polyglutamine. However, the mechanism by which polyglutamine causes ER membrane distortion remains unclear. We used electron microscopy, fluorescence protease protection assay, and alkaline treatment to analyze the localization of polyglutamine in cells. We characterized polyglutamine embedded in the ER membrane and noted an effect on morphology, including the dilation of ER luminal space and elongation of ER-mitochondria contact sites, in addition to the distortion of the nuclear envelope. The polyglutamine embedded in the ER membrane was observed at the same time as Bax insertion. These results demonstrated that the ER membrane may be a target of polyglutamine, which triggers cell death through Bax. -- Highlights: •We characterized polyglutamine embedded in the ER membrane. •The polyglutamine embedded in the ER membrane was observed at the same time as Bax insertion. •The ER membrane may be a target of polyglutamine, which triggers cell death.

Poincaré Embeddings for Learning Hierarchical Representations

CERN Multimedia

CERN. Geneva

2018-01-01

Abstracts: Representation learning has become an invaluable approach for learning from symbolic data such as text and graphs. However, while complex symbolic datasets often exhibit a latent hierarchical structure, state-of-the-art methods typically do not account for this property. In this talk, I will discuss a new approach for learning hierarchical representations of symbolic data by embedding them into hyperbolic space -- or more precisely into an n-dimensional Poincaré ball. Due to the underlying hyperbolic geometry, this allows us to learn parsimonious representations of symbolic data by simultaneously capturing hierarchy and similarity. We introduce an efficient algorithm to learn the embeddings based on Riemannian optimization and show experimentally that Poincaré embeddings outperform Euclidean embeddings significantly on data with latent hierarchies, both in terms of representation capacity and in terms of generalization ability.      &...

Embedded systems handbook networked embedded systems

CERN Document Server

Zurawski, Richard

2009-01-01

Considered a standard industry resource, the Embedded Systems Handbook provided researchers and technicians with the authoritative information needed to launch a wealth of diverse applications, including those in automotive electronics, industrial automated systems, and building automation and control. Now a new resource is required to report on current developments and provide a technical reference for those looking to move the field forward yet again. Divided into two volumes to accommodate this growth, the Embedded Systems Handbook, Second Edition presents a comprehensive view on this area

Diverse Power Iteration Embeddings and Its Applications

Energy Technology Data Exchange (ETDEWEB)

Huang H.; Yoo S.; Yu, D.; Qin, H.

2014-12-14

Abstract—Spectral Embedding is one of the most effective dimension reduction algorithms in data mining. However, its computation complexity has to be mitigated in order to apply it for real-world large scale data analysis. Many researches have been focusing on developing approximate spectral embeddings which are more efficient, but meanwhile far less effective. This paper proposes Diverse Power Iteration Embeddings (DPIE), which not only retains the similar efficiency of power iteration methods but also produces a series of diverse and more effective embedding vectors. We test this novel method by applying it to various data mining applications (e.g. clustering, anomaly detection and feature selection) and evaluating their performance improvements. The experimental results show our proposed DPIE is more effective than popular spectral approximation methods, and obtains the similar quality of classic spectral embedding derived from eigen-decompositions. Moreover it is extremely fast on big data applications. For example in terms of clustering result, DPIE achieves as good as 95% of classic spectral clustering on the complex datasets but 4000+ times faster in limited memory environment.

A Foundation for Embedded Languages

DEFF Research Database (Denmark)

Rhiger, Morten

2003-01-01

Recent work on embedding object languages into Haskell use "phantom types" (i.e., parameterized types whose parameter does not occur on the right-hand side of the type definition) to ensure that the embedded object-language terms are simply typed. But is it a safe assumption that only simply......-typed terms can be represented in Haskell using phantom types? And conversely, can all simply-typed terms be represented in Haskell under the restrictions imposed by phantom types? In this article we investigate the conditions under which these assumptions are true: We show that these questions can...

A Foundation for Embedded Languages

DEFF Research Database (Denmark)

Rhiger, Morten

2002-01-01

Recent work on embedding object languages into Haskell use "phantom types" (i.e., parameterized types whose parameter does not occur on the right-hand side of the type definition) to ensure that the embedded object-language terms are simply typed. But is it a safe assumption that only simply......-typed terms can be represented in Haskell using phantom types? And conversely, can all simply-typed terms be represented in Haskell under the restrictions imposed by phantom types? In this article we investigate the conditions under which these assumptions are true: We show that these questions can...

NCR1+ cells in dogs show phenotypic characteristics of natural killer cells.

Science.gov (United States)

Grøndahl-Rosado, Christine; Bønsdorff, Tina B; Brun-Hansen, Hege C; Storset, Anne K

2015-03-01

No specific markers for natural killer (NK) cells in dogs have currently been described. NCR1 (NKp46, CD355) has been considered a pan species NK cell marker and is expressed on most or all NK cells in all species investigated except for the pig which has both a NCR1(+) and a NCR1(-) population. In this study peripheral blood mononuclear cells (PBMC) from 14 healthy dogs, 37 dogs with a clinical diagnosis, including a dog diagnosed with LGL leukemia, and tissue samples from 8 dogs were evaluated for NCR1(+) expression by a cross reacting anti bovine NCR1 antibody. CD3(-)NCR1(+) cells were found in the blood of 93 % of healthy dogs and comprised up to 2.5 % of lymphocytes in PBMC. In a selection of healthy dogs, sampling and immunophenotyping were repeated throughout a period of 1 year revealing a substantial variation in the percentage of CD3(-)NCR1(+) over time. Dogs allocated to 8 disease groups had comparable amounts of CD3(-)NCR1(+) cells in PBMC to the healthy individuals. All organs examined including liver, spleen and lymph nodes contained CD3(-)NCR1(+) cells. Circulating CD3(-)NCR1(+) cells were further characterized as CD56(-)GranzymeB(+)CD8(-). A CD3(+)NCR1(+) population was observed in PBMC in 79 % of the healthy dogs examined representing at the most 4.8 % of the lymphocyte population. In canine samples examined for CD56 expression, CD56(+) cells were all CD3(+) and NCR1(-). To our knowledge, this is the first examination of NCR1 expression in the dog. The study shows that this NK cell associated receptor is expressed both on populations of CD3(+) and CD3(-) blood lymphocytes in dogs and the receptor is found on a CD3(+) GranzymeB(+) CD8(+) leukemia. Our results support that CD56 is expressed only on CD3(+) cells in dogs and shows that NCR1 defines a different CD3(+) lymphocyte population than CD56(+)CD3(+) cells in this species. CD3(-)NCR1(+) cells may represent canine NK cells.

Embedded Linux in het onderwijs

NARCIS (Netherlands)

Dr Ruud Ermers

2008-01-01

Embedded Linux wordt bij steeds meer grote bedrijven ingevoerd als embedded operating system. Binnen de opleiding Technische Informatica van Fontys Hogeschool ICT is Embedded Linux geïntroduceerd in samenwerking met het lectoraat Architectuur van Embedded Systemen. Embedded Linux is als vakgebied

GLAUBERITE-HALITE ASSOCIATION IN BOZKIR FORMATION (PLİOCENE, ÇANKIRI-ÇORUM BASİN, CENTRAL ANATOLİA, TURKEY

Directory of Open Access Journals (Sweden)

İLHAN SÖNMEZ

2015-06-01

Full Text Available Tertiary Çankırı – Çorum Basin is one of the biggest basin covering evaporitic formationsin the Central Anatolia. During borehole drills carried out in Bozkır Formation whichcontain Pliocene aged evaporites in the basin, a thick rocksalt (halite, NaCl deposit wasdetected that consisting of glauberite (Na2Ca(SO42 interlayers (sabhka synchronouswith sedimentation. Rocksalt bearing layers in Bozkır formation which was deposited inplaya-lake – sabhka environment, where seasonal changes are effective, were first definedas Tuz member in this study. Bozkır formation was divided into three zones in drillingscarried out in sabhka – playa -lake transitional environment. From bottom to top, these areordered as claystone-less anhydrite zone, rock salt-claystone-anhydrite-glauberite zone(Tuz member and claystone-gypsum-less anhydrite zone. Rocksalt was cut in thicknessesreaching 115 meters within Tuz member. Rocksalt (playa-lake which is mostly bedded andwhite, pale/dark gray colored is conformable with sedimentation and is low dipping. The1. Girifl

Study on aseismic design of embedded structures in soft ground, 1

International Nuclear Information System (INIS)

Tohma, Jun-ichi; Kokusho, Takaji; Iwatate, Takahiro

1984-01-01

Shaking table tests were performed to clarify dynamic responses of a embedded duct in relatively soft sandy ground. Response characteristics of the coupled duct-soil system along its transverse direction are as follows. (1) Horizontal acceleration response in the deep embedded duct shows its oscillating characteristics identical to the surrounding soil response. (2) Dynamic soil pressure distribution in the deep embedded duct shows a shift to and from compression and tension along its walls. (3) The over-all distribution of the bending strain in the duct shows a lateral distortion pattern due to shearing deformation of the ground. In the shallow embedded duct, response amplitude become reduced. (4) Due to strong nonlinearity in the response of the surrounding soil, the dynamic response including soil pressure become less than linear response. (author)

Embedding beyond electrostatics-The role of wave function confinement.

Science.gov (United States)

Nåbo, Lina J; Olsen, Jógvan Magnus Haugaard; Holmgaard List, Nanna; Solanko, Lukasz M; Wüstner, Daniel; Kongsted, Jacob

2016-09-14

We study excited states of cholesterol in solution and show that, in this specific case, solute wave-function confinement is the main effect of the solvent. This is rationalized on the basis of the polarizable density embedding scheme, which in addition to polarizable embedding includes non-electrostatic repulsion that effectively confines the solute wave function to its cavity. We illustrate how the inclusion of non-electrostatic repulsion results in a successful identification of the intense π → π(∗) transition, which was not possible using an embedding method that only includes electrostatics. This underlines the importance of non-electrostatic repulsion in quantum-mechanical embedding-based methods.

The data embedding method

Energy Technology Data Exchange (ETDEWEB)

Sandford, M.T. II; Bradley, J.N.; Handel, T.G.

1996-06-01

Data embedding is a new steganographic method for combining digital information sets. This paper describes the data embedding method and gives examples of its application using software written in the C-programming language. Sandford and Handel produced a computer program (BMPEMBED, Ver. 1.51 written for IBM PC/AT or compatible, MS/DOS Ver. 3.3 or later) that implements data embedding in an application for digital imagery. Information is embedded into, and extracted from, Truecolor or color-pallet images in Microsoft{reg_sign} bitmap (.BMP) format. Hiding data in the noise component of a host, by means of an algorithm that modifies or replaces the noise bits, is termed {open_quote}steganography.{close_quote} Data embedding differs markedly from conventional steganography, because it uses the noise component of the host to insert information with few or no modifications to the host data values or their statistical properties. Consequently, the entropy of the host data is affected little by using data embedding to add information. The data embedding method applies to host data compressed with transform, or {open_quote}lossy{close_quote} compression algorithms, as for example ones based on discrete cosine transform and wavelet functions. Analysis of the host noise generates a key required for embedding and extracting the auxiliary data from the combined data. The key is stored easily in the combined data. Images without the key cannot be processed to extract the embedded information. To provide security for the embedded data, one can remove the key from the combined data and manage it separately. The image key can be encrypted and stored in the combined data or transmitted separately as a ciphertext much smaller in size than the embedded data. The key size is typically ten to one-hundred bytes, and it is in data an analysis algorithm.

Fish kidney cells show higher tolerance to hyperosmolality than amphibian

Directory of Open Access Journals (Sweden)

Lang Gui

2018-05-01

Full Text Available In contrast to fish, amphibians inhabit both aquatic and terrestrial environments. To better understand osmoregulation in fish and amphibian, we have investigated the morphological changes in kidney cells to osmotic stress. To address this, kidney cell line isolated from the freshwater grass carp (CIK and Chinese giant salamander (GSK were challenged to different mediums with distinct osmotic pressures (100, 300 and 700 mOsm. Morphological alterations of the fish and amphibian cells were compared by optical and electron microscopy. Following hyposmotic treatment (100 mOsm, both CIK and GSK cells became unhealthy and show condensed chromatin, swollen mitochondria and cytoplasmic vacuole. Meanwhile, after hyperosmotic treatment (700 mOsm, shrunken CIK cells with multipolar shape, pale or lightly stained cytoplasm, condensed chromatin, vacuoles and swollen mitochondria were detected. GSK cells were seriously damaged and most were completely lysed. The results suggest that fish kidney cells show a higher degree of tolerance to hyperosmoticity by comparing to amphibians and provide novel insights on the osmoregulatory capacity and adaptability of kidney cells between the two animal groups.

Modeling Electronic Circular Dichroism within the Polarizable Embedding Approach

DEFF Research Database (Denmark)

Nørby, Morten S; Olsen, Jógvan Magnus Haugaard; Steinmann, Casper

2017-01-01

We present a systematic investigation of the key components needed to model single chromophore electronic circular dichroism (ECD) within the polarizable embedding (PE) approach. By relying on accurate forms of the embedding potential, where especially the inclusion of local field effects...... are in focus, we show that qualitative agreement between rotatory strength parameters calculated by full quantum mechanical calculations and the more efficient embedding calculations can be obtained. An important aspect in the computation of reliable absorption parameters is the need for conformational...... sampling. We show that a significant number of snapshots are needed to avoid artifacts in the calculated electronic circular dichroism parameters due to insufficient configurational sampling, thus highlighting the efficiency of the PE model....

Co-design for an SoC embedded network controller

Institute of Scientific and Technical Information of China (English)

无

2006-01-01

With the development of Ethernet systems and the growing capacity of modern silicon technology, embedded communication networks are playing an increasingly important role in embedded and safety critical systems. Hardware/software co-design is a methodology for solving design problems in processor based embedded systems. In this work, we implemented a new 1-cycle pipeline microprocessor and a fast Ethernet transceiver and established a low cost, high performance embedded network controller, and designed a TCP/IP stack to access the Internet. We discussed the hardware/software architecture in the forepart, and then the whole system-on-a-chip on Altera Stratix EP1S25F780C6 device. Using the FPGA environment and SmartBit tester, we tested the system's throughput. Our simulation results showed that the maximum throughput of Ethernet packets is up to 7 Mbps, that of UDP packets is up to 5.8 Mbps, and that of TCP packets is up to 3.4 Mbps, which showed that this embedded system can easily transmit basic voice and video signals through Ethernet, and that using only one chip can realize that many electronic devices access to the Internet directly and get high performance.

Enhanced Performance of Nanowire-Based All-TiO2 Solar Cells using Subnanometer-Thick Atomic Layer Deposited ZnO Embedded Layer

International Nuclear Information System (INIS)

Ghobadi, Amir; Yavuz, Halil I.; Ulusoy, T. Gamze; Icli, K. Cagatay; Ozenbas, Macit; Okyay, Ali K.

2015-01-01

In this paper, the effect of angstrom-thick atomic layer deposited (ALD) ZnO embedded layer on photovoltaic (PV) performance of Nanowire-Based All-TiO 2 solar cells has been systematically investigated. Our results indicate that by varying the thickness of ZnO layer the efficiency of the solar cell can be significantly changed. It is shown that the efficiency has its maximum for optimal thickness of 1 ALD cycle in which this ultrathin ZnO layer improves device performance through passivation of surface traps without hampering injection efficiency of photogenerated electrons. The mechanisms contributing to this unprecedented change in PV performance of the cell have been scrutinized and discussed

Embedded engineering education

CERN Document Server

Kaštelan, Ivan; Temerinac, Miodrag; Barak, Moshe; Sruk, Vlado

2016-01-01

This book focuses on the outcome of the European research project “FP7-ICT-2011-8 / 317882: Embedded Engineering Learning Platform” E2LP. Additionally, some experiences and researches outside this project have been included. This book provides information about the achieved results of the E2LP project as well as some broader views about the embedded engineering education. It captures project results and applications, methodologies, and evaluations. It leads to the history of computer architectures, brings a touch of the future in education tools and provides a valuable resource for anyone interested in embedded engineering education concepts, experiences and material. The book contents 12 original contributions and will open a broader discussion about the necessary knowledge and appropriate learning methods for the new profile of embedded engineers. As a result, the proposed Embedded Computer Engineering Learning Platform will help to educate a sufficient number of future engineers in Europe, capable of d...

Cold thyroid nodules show a marked increase in proliferation markers.

Science.gov (United States)

Krohn, Knut; Stricker, Ingo; Emmrich, Peter; Paschke, Ralf

2003-06-01

Thyroid follicular adenomas and adenomatous thyroid nodules are a frequent finding in geographical areas with iodine deficiency. They occur as hypofunctioning (scintigraphically cold) or hyperfunctioning (scintigraphically hot) nodules. Their predominant clonal origin suggests that they result from clonal expansion of a single cell, which is very likely the result of a prolonged increase in proliferation compared with non-affected surrounding cells. To test whether increased cell proliferation is detectable in cold thyroid nodules, we studied paraffin-embedded tissue from 40 cold thyroid nodules and their surrounding normal thyroid tissue for the occurrence of the proliferating cell nuclear antigen (PCNA) and Ki-67 (MIB-1 antibody) epitopes as markers for cell proliferation. All 40 thyroid nodules were histologically well characterized and have been studied for molecular characteristics before. The labeling index (number of labeled cells versus total cell number) for nodular and surrounding tissue was calculated. In 33 cold thyroid nodules a significant (p thyroid nodules a significant (p thyroid epithelial cell proliferation is a uniform feature common to most cold nodules. However, the increase of proliferation markers shows a heterogeneity that is not correlated with histopathologic, molecular, or clinical characteristics.

Surface Embedded Metal Oxide Sensors (SEMOS)

DEFF Research Database (Denmark)

Jespersen, Jesper Lebæk; Talat Ali, Syed; Pleth Nielsen, Lars

SEMOS is a joint project between Aalborg University, Danish Technological Institute and Danish Technical University in which micro temperature sensors and metal oxide-based gas sensors are developed and tested in a simulated fuel cell environment as well as in actual working fuel cells. Initially......, sensors for measuring the temperatures in an operating HT-PEM (High Temperature-Proton Exchange Membrane) fuel cell are developed for detecting in-plane temperature variations. 5 different tracks for embedded thermal sensors are investigated. The fuel cell MEA (Membrane Electrode Assembly) is quite...... complex and sensors are not easily implemented in the construction. Hence sensor interface and sensor position must therefore be chosen carefully in order to make the sensors as non-intrusive as possible. Metal Oxide Sensors (MOX) for measuring H2, O2 and CO concentration in a fuel cell environment...

Embedded Processor Laboratory

Data.gov (United States)

Federal Laboratory Consortium — The Embedded Processor Laboratory provides the means to design, develop, fabricate, and test embedded computers for missile guidance electronics systems in support...

Comparative investigations of T cell receptor gamma gene rearrangements in frozen and formalin-fixed paraffin wax-embedded tissues by capillary electrophoresis

DEFF Research Database (Denmark)

Christensen, M; Funder, A D; Bendix, K

2006-01-01

AIM: To compare clonal T cell receptor gamma (TCRgamma) gene rearrangements in frozen and formalin-fixed paraffin wax-embedded (FFPE) tissue, using capillary electrophoresis for use in diagnostics, as T cell lymphomas may be difficult to diagnose by conventional methods.METHODS: The DNA for PCR......% for patient specimens and the specificity 100%. The junctional region between the Vgamma and Jgamma segments was specific for each patient.CONCLUSIONS: Capillary electrophoresis of PCR products from frozen and FFPE tissue is suitable for detecting clonal TCRgamma gene rearrangements. It is important, however...

Java Dust: How Small Can Embedded Java Be?

DEFF Research Database (Denmark)

Caska, James; Schoeberl, Martin

2011-01-01

Java is slowly being accepted as a language and platform for embedded devices. However, the memory requirements of the Java library and runtime are still troublesome. A Java system is considered small when it requires less than 1 MB, and within the embedded domain small microcontollers with a few...... KB on-chip Flash memory and even less on-chip RAM are very common. For such small devices Java is a clearly challenging. In this paper we present the combination of the Java compiler Muvium for microcontrollers with the tiny soft-core Leros for an FPGA. To the best of our knowledge, the presented...... embedded Java system is the smallest Java system available. The Leros processor consumes less than 5% of the logic cells of the smallest FPGA from Altera and the Muvium compiler produces a JVM, including the Java application, that can execute in a few KB ROM and less than 1 KB RAM. The Leros processor...

Potential-functional embedding theory for molecules and materials.

Science.gov (United States)

Huang, Chen; Carter, Emily A

2011-11-21

We introduce a potential-functional embedding theory by reformulating a recently proposed density-based embedding theory in terms of functionals of the embedding potential. This potential-functional based theory completes the dual problem in the context of embedding theory for which density-functional embedding theory has existed for two decades. With this potential-functional formalism, it is straightforward to solve for the unique embedding potential shared by all subsystems. We consider charge transfer between subsystems and discuss how to treat fractional numbers of electrons in subsystems. We show that one is able to employ different energy functionals for different subsystems in order to treat different regions with theories of different levels of accuracy, if desired. The embedding potential is solved for by directly minimizing the total energy functional, and we discuss how to efficiently calculate the gradient of the total energy functional with respect to the embedding potential. Forces are also derived, thereby making it possible to optimize structures and account for nuclear dynamics. We also extend the theory to spin-polarized cases. Numerical examples of the theory are given for some homo- and hetero-nuclear diatomic molecules and a more complicated test of a six-hydrogen-atom chain. We also test our theory in a periodic bulk environment with calculations of basic properties of bulk NaCl, by treating each atom as a subsystem. Finally, we demonstrate the theory for water adsorption on the MgO(001)surface.

Embedded and real-time operating systems

CERN Document Server

Wang, K C

2017-01-01

This book covers the basic concepts and principles of operating systems, showing how to apply them to the design and implementation of complete operating systems for embedded and real-time systems. It includes all the foundational and background information on ARM architecture, ARM instructions and programming, toolchain for developing programs, virtual machines for software implementation and testing, program execution image, function call conventions, run-time stack usage and link C programs with assembly code. It describes the design and implementation of a complete OS for embedded systems in incremental steps, explaining the design principles and implementation techniques. For Symmetric Multiprocessing (SMP) embedded systems, the author examines the ARM MPcore processors, which include the SCU and GIC for interrupts routing and interprocessor communication and synchronization by Software Generated Interrupts (SGIs). Throughout the book, complete working sample systems demonstrate the design principles and...

Topological Embedding Feature Based Resource Allocation in Network Virtualization

Directory of Open Access Journals (Sweden)

Hongyan Cui

2014-01-01

Full Text Available Virtualization provides a powerful way to run multiple virtual networks on a shared substrate network, which needs accurate and efficient mathematical models. Virtual network embedding is a challenge in network virtualization. In this paper, considering the degree of convergence when mapping a virtual network onto substrate network, we propose a new embedding algorithm based on topology mapping convergence-degree. Convergence-degree means the adjacent degree of virtual network’s nodes when they are mapped onto a substrate network. The contributions of our method are as below. Firstly, we map virtual nodes onto the substrate nodes with the maximum convergence-degree. The simulation results show that our proposed algorithm largely enhances the network utilization efficiency and decreases the complexity of the embedding problem. Secondly, we define the load balance rate to reflect the load balance of substrate links. The simulation results show our proposed algorithm achieves better load balance. Finally, based on the feature of star topology, we further improve our embedding algorithm and make it suitable for application in the star topology. The test result shows it gets better performance than previous works.

A Middleware Platform for Providing Mobile and Embedded Computing Instruction to Software Engineering Students

Science.gov (United States)

Mattmann, C. A.; Medvidovic, N.; Malek, S.; Edwards, G.; Banerjee, S.

2012-01-01

As embedded software systems have grown in number, complexity, and importance in the modern world, a corresponding need to teach computer science students how to effectively engineer such systems has arisen. Embedded software systems, such as those that control cell phones, aircraft, and medical equipment, are subject to requirements and…

The Modified Embedded Atom Method

Energy Technology Data Exchange (ETDEWEB)

Baskes, M.I.

1994-08-01

Recent modifications have been made to generalize the Embedded Atom Method (EAM) to describe bonding in diverse materials. By including angular dependence of the electron density in an empirical way, the Modified Embedded Atom Method (MEAM) has been able to reproduce the basic energetic and structural properties of 45 elements. This method is ideal for examining interfacial behavior of dissimilar materials. This paper explains in detail the derivation of the method, shows how parameters of MEAM are determined directly from experiment or first principles calculations, and examine the quality of the reproduction of the database. Materials with fcc, bcc, hcp, and diamond cubic crystal structure are discussed. A few simple examples of the application of the MEAM to surfaces and interfaces are presented. Calculations of pullout of a SiC fiber in a diamond matrix as a function of applied stress show nonuniform deformation of the fiber.

A method to evaluate genome-wide methylation in archival formalin-fixed, paraffin-embedded ovarian epithelial cells.

Directory of Open Access Journals (Sweden)

Qiling Li

Full Text Available The use of DNA from archival formalin and paraffin embedded (FFPE tissue for genetic and epigenetic analyses may be problematic, since the DNA is often degraded and only limited amounts may be available. Thus, it is currently not known whether genome-wide methylation can be reliably assessed in DNA from archival FFPE tissue.Ovarian tissues, which were obtained and formalin-fixed and paraffin-embedded in either 1999 or 2011, were sectioned and stained with hematoxylin-eosin (H&E.Epithelial cells were captured by laser micro dissection, and their DNA subjected to whole genomic bisulfite conversion, whole genomic polymerase chain reaction (PCR amplification, and purification. Sequencing and software analyses were performed to identify the extent of genomic methylation. We observed that 31.7% of sequence reads from the DNA in the 1999 archival FFPE tissue, and 70.6% of the reads from the 2011 sample, could be matched with the genome. Methylation rates of CpG on the Watson and Crick strands were 32.2% and 45.5%, respectively, in the 1999 sample, and 65.1% and 42.7% in the 2011 sample.We have developed an efficient method that allows DNA methylation to be assessed in archival FFPE tissue samples.

Embedded multiprocessors scheduling and synchronization

CERN Document Server

Sriram, Sundararajan

2009-01-01

Techniques for Optimizing Multiprocessor Implementations of Signal Processing ApplicationsAn indispensable component of the information age, signal processing is embedded in a variety of consumer devices, including cell phones and digital television, as well as in communication infrastructure, such as media servers and cellular base stations. Multiple programmable processors, along with custom hardware running in parallel, are needed to achieve the computation throughput required of such applications. Reviews important research in key areas related to the multiprocessor implementation of multi

Time-dependent embedding

OpenAIRE

Inglesfield, J. E.

2007-01-01

A method of solving the time-dependent Schr\\"odinger equation is presented, in which a finite region of space is treated explicitly, with the boundary conditions for matching the wave-functions on to the rest of the system replaced by an embedding term added on to the Hamiltonian. This time-dependent embedding term is derived from the Fourier transform of the energy-dependent embedding potential, which embeds the time-independent Schr\\"odinger equation. Results are presented for a one-dimensi...

Field tests on partial embedment effects (embedment effect tests on soil-structure interaction)

International Nuclear Information System (INIS)

Kurimoto, O.; Tsunoda, T.; Inoue, T.; Izumi, M.; Kusakabe, K.; Akino, K.

1993-01-01

A series of Model Tests of Embedment Effect on Reactor Buildings has been carried out by the Nuclear Power Engineering Corporation (NUPEC), under the sponsorship of the Ministry of International Trade and lndustry (MITI) of Japan. The nuclear reactor buildings are partially embedded due to conditions for the construction or building arrangement in Japan. It is necessary to verify the partial embedment effects by experiments and analytical studies in order to incorporate the effects in the seismic design. Forced vibration tests, therefore, were performed using a model with several types of embedment. Correlated simulation analyses were also performed and the characteristics of partial embedment effects on soil-structure interaction were evaluated. (author)

Embedded Systems Design: Optimization Challenges

DEFF Research Database (Denmark)

Pop, Paul

2005-01-01

Summary form only given. Embedded systems are everywhere: from alarm clocks to PDAs, from mobile phones to cars, almost all the devices we use are controlled by embedded systems. Over 99% of the microprocessors produced today are used in embedded systems, and recently the number of embedded systems...

Roll-to-roll embedded conductive structures integrated into organic photovoltaic devices

International Nuclear Information System (INIS)

Van de Wiel, H J; Galagan, Y; Van Lammeren, T J; De Riet, J F J; Gilot, J; Nagelkerke, M G M; Lelieveld, R H C A T; Shanmugam, S; Pagudala, A; Groen, W A; Hui, D

2013-01-01

Highly conductive screen printed metallic (silver) structures (current collecting grids) combined with poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) are a viable replacement for indium tin oxide (ITO) and inkjet printed silver as transparent electrode materials. To provide successful integration into organic photovoltaic (OPV) devices, screen printed silver current collecting grids should be embedded into a substrate to avoid topology issues. In this study micron-thick conductive structures are embedded and integrated into OPV devices. The embedded structures are produced roll-to-roll with optimized process settings and materials. Topology measurements show that the embedded grids are well suited for integration into OPV devices since the surface is almost without spikes and has low surface roughness. JV measurements of OPV devices with embedded structures on a polyethylene terephthalate/silicon nitride (PET/SiN) substrate show an efficiency of 2.15%, which is significantly higher than identical flexible devices with ITO (1.02%) and inkjet printed silver (1.48%). The use of embedded screen printed silver instead of ITO and inkjet printed silver in OPV devices will allow for higher efficiency devices which can be produced with larger design and process freedom. (paper)

Checkpointing for graceful degradation in distributed embedded systems

Science.gov (United States)

Sababha, Belal Hussein

Graceful degradation is an approach to developing dependable safety-critical embedded applications, where redundant active or standby resources are used to cope with faults through a system reconfiguration at run-time. Compared to traditional hardware and software redundancy, it is a promising technique that may achieve dependability with a significant reduction in cost, size, weight, and power requirements. Reconfiguration at run-time necessitates using proper checkpointing protocols to support state reservation to ensure correct task restarts after a system reconfiguration. One of the most common checkpointing protocols are communication induced checkpointing (CIC) protocols, which are well developed and understood for large parallel and information systems, but not much has been done for resource limited embedded systems. This work implements and evaluates some of the most common CIC protocols in a periodic resource constrained distributed embedded system for graceful degradation purposes. A test-bed has been developed and used for the evaluation of the various protocols. The implemented protocols are thoroughly studied and performances are contrasted. Specifically the periodicity property and how it benefits checkpointing in embedded systems is investigated. This work introduces a unique effort of CIC protocol implementation and evaluation in the field of distributed embedded systems. Other than providing a test-bed for graceful degradation support, this work shows that some checkpointing protocols that are not efficient in large information systems and supercomputers perform well in embedded systems. We show that a simple index-based CIC protocol, such as the BCS protocol, is more appropriate in embedded system applications compared to other protocols that piggyback a significant amount of information to reduce the number of forced checkpoints. Finally, this work proposes a whole graceful degradation approach to achieve fault tolerance in resource constrained

Fabrication of a nanosize-Pt-embedded membrane electrode assembly to enhance the utilization of Pt in proton exchange membrane fuel cells.

Science.gov (United States)

Choe, Junseok; Kim, Doyoung; Shim, Jinyong; Lee, Inhae; Tak, Yongsug

2011-08-01

A procedure to locate the Pt nanostructure inside the hydrophilic channel of a Nafion membrane was developed in order to enhance Pt utilization in PEMFCs. Nanosize Pt-embedded MEA was constructed by Cu electroless plating and subsequent Pt electrodeposition inside the hydrophilic channels of the Nafion membrane. The metallic Pt nanostructure fabricated inside the membrane was employed as an oxygen reduction catalyst for a PEMFC and facilitated effective use of the hydrophilic channels inside the membrane. Compared to the conventional MEA, a Pt-embedded MEA with only 68% Pt loading showed better PEMFC performance.

Word embeddings quantify 100 years of gender and ethnic stereotypes.

Science.gov (United States)

Garg, Nikhil; Schiebinger, Londa; Jurafsky, Dan; Zou, James

2018-04-17

Word embeddings are a powerful machine-learning framework that represents each English word by a vector. The geometric relationship between these vectors captures meaningful semantic relationships between the corresponding words. In this paper, we develop a framework to demonstrate how the temporal dynamics of the embedding helps to quantify changes in stereotypes and attitudes toward women and ethnic minorities in the 20th and 21st centuries in the United States. We integrate word embeddings trained on 100 y of text data with the US Census to show that changes in the embedding track closely with demographic and occupation shifts over time. The embedding captures societal shifts-e.g., the women's movement in the 1960s and Asian immigration into the United States-and also illuminates how specific adjectives and occupations became more closely associated with certain populations over time. Our framework for temporal analysis of word embedding opens up a fruitful intersection between machine learning and quantitative social science.

Hawking into Unruh mapping for embeddings of hyperbolic type

International Nuclear Information System (INIS)

Paston, S A

2015-01-01

We study the conditions of the existence of Hawking into Unruh mapping for hyperbolic (Fronsdal-type) metric embeddings into the Minkowski space, for which timelines are hyperbolas. Many examples are known for global embeddings into the Minkowskian spacetime (GEMS), with such mapping for physically interesting metrics with some symmetry. However, examples of embeddings, both smooth and hyperbolic, for which there is no mapping, were also given. In the present work we prove that Hawking into Unruh mapping takes place for a hyperbolic embedding of an arbitrary metric with a time-like Killing vector and a Killing horizon if the embedding of such type exists and smoothly covers the horizon. At the same time, we do not assume any symmetry (spherical, for example), except the time translational invariance, which corresponds to the existence of a time-like Killing vector. We show that the known examples of the absence of mapping do not satisfy the formulated conditions of its existence. (paper)

Embedded software verification and debugging

CERN Document Server

Winterholer, Markus

2017-01-01

This book provides comprehensive coverage of verification and debugging techniques for embedded software, which is frequently used in safety critical applications (e.g., automotive), where failures are unacceptable. Since the verification of complex systems needs to encompass the verification of both hardware and embedded software modules, this book focuses on verification and debugging approaches for embedded software with hardware dependencies. Coverage includes the entire flow of design, verification and debugging of embedded software and all key approaches to debugging, dynamic, static, and hybrid verification. This book discusses the current, industrial embedded software verification flow, as well as emerging trends with focus on formal and hybrid verification and debugging approaches. Includes in a single source the entire flow of design, verification and debugging of embedded software; Addresses the main techniques that are currently being used in the industry for assuring the quality of embedded softw...

Isometric embeddings of 2-spheres by embedding flow for applications in numerical relativity

International Nuclear Information System (INIS)

Jasiulek, Michael; Korzyński, Mikołaj

2012-01-01

We present a numerical method for solving Weyl's embedding problem which consists in finding a global isometric embedding of a positively curved and positive-definite spherical 2-metric into the Euclidean 3-space. The method is based on a construction introduced by Weingarten and was used in Nirenberg's proof of Weyl's conjecture. The target embedding results as the endpoint of an embedding flow in R 3 beginning at the unit sphere's embedding. We employ spectral methods to handle functions on the surface and to solve various (non)linear elliptic PDEs. The code requires no additional input or steering from the operator and its convergence is guaranteed by the Nirenberg arguments. Possible applications in 3 + 1 numerical relativity range from quasi-local mass and momentum measures to coarse-graining in inhomogeneous cosmological models. (paper)

The extreme vulnerability of interdependent spatially embedded networks

Science.gov (United States)

Bashan, Amir; Berezin, Yehiel; Buldyrev, Sergey V.; Havlin, Shlomo

2013-10-01

Recent studies show that in interdependent networks a very small failure in one network may lead to catastrophic consequences. Above a critical fraction of interdependent nodes, even a single node failure can invoke cascading failures that may abruptly fragment the system, whereas below this critical dependency a failure of a few nodes leads only to a small amount of damage to the system. So far, research has focused on interdependent random networks without space limitations. However, many real systems, such as power grids and the Internet, are not random but are spatially embedded. Here we analytically and numerically study the stability of interdependent spatially embedded networks modelled as lattice networks. Surprisingly, we find that in lattice systems, in contrast to non-embedded systems, there is no critical dependency and any small fraction of interdependent nodes leads to an abrupt collapse. We show that this extreme vulnerability of very weakly coupled lattices is a consequence of the critical exponent describing the percolation transition of a single lattice.

Bacterial filamentation accelerates colonization of adhesive spots embedded in biopassive surfaces

International Nuclear Information System (INIS)

Möller, Jens; Emge, Philippe; Vizcarra, Ima Avalos; Kollmannsberger, Philip; Vogel, Viola

2013-01-01

Sessile bacteria adhere to engineered surfaces and host tissues and pose a substantial clinical and economical risk when growing into biofilms. Most engineered and biological interfaces are of chemically heterogeneous nature and provide adhesive islands for bacterial attachment and growth. To mimic either defects in a surface coating of biomedical implants or heterogeneities within mucosal layers (Peyer's patches), we embedded micrometre-sized adhesive islands in a poly(ethylene glycol) biopassive background. We show experimentally and computationally that filamentation of Escherichia coli can significantly accelerate the bacterial surface colonization under physiological flow conditions. Filamentation can thus provide an advantage to a bacterial population to bridge non-adhesive distances exceeding 5 μm. Bacterial filamentation, caused by blocking of bacterial division, is common among bacterial species and can be triggered by environmental conditions or antibiotic treatment. While great awareness exists that the build-up of antibiotic resistance serves as intrinsic survival strategy, we show here that antibiotic treatment can actually promote surface colonization by triggering filamentation, which in turn prevents daughter cells from being washed away. Our combined microfabrication and computational approaches provide quantitative insights into mechanisms that enable biofouling of biopassive surfaces with embedded adhesive spots, even for spot distances that are multiples of the bacterial length. (paper)

Bacterial filamentation accelerates colonization of adhesive spots embedded in biopassive surfaces

Science.gov (United States)

Möller, Jens; Emge, Philippe; Avalos Vizcarra, Ima; Kollmannsberger, Philip; Vogel, Viola

2013-12-01

Sessile bacteria adhere to engineered surfaces and host tissues and pose a substantial clinical and economical risk when growing into biofilms. Most engineered and biological interfaces are of chemically heterogeneous nature and provide adhesive islands for bacterial attachment and growth. To mimic either defects in a surface coating of biomedical implants or heterogeneities within mucosal layers (Peyer's patches), we embedded micrometre-sized adhesive islands in a poly(ethylene glycol) biopassive background. We show experimentally and computationally that filamentation of Escherichia coli can significantly accelerate the bacterial surface colonization under physiological flow conditions. Filamentation can thus provide an advantage to a bacterial population to bridge non-adhesive distances exceeding 5 μm. Bacterial filamentation, caused by blocking of bacterial division, is common among bacterial species and can be triggered by environmental conditions or antibiotic treatment. While great awareness exists that the build-up of antibiotic resistance serves as intrinsic survival strategy, we show here that antibiotic treatment can actually promote surface colonization by triggering filamentation, which in turn prevents daughter cells from being washed away. Our combined microfabrication and computational approaches provide quantitative insights into mechanisms that enable biofouling of biopassive surfaces with embedded adhesive spots, even for spot distances that are multiples of the bacterial length.

Halit Fahri Ozansoy'un Gülistanlar ve Harabeler Adlı Eserinde Bahçe İmajları ve Renkler Garden Images and Colors in Halit Fahri Ozansoy’s Work of Gülistanlar ve Harabeler

Directory of Open Access Journals (Sweden)

Hüseyin DOĞRAMACIOĞLU

2012-12-01

Full Text Available Halit Fahri Ozansoy’s poetry books of Gülistanlar ve Harabeler printed with old letters but not transformed to the Latin alphabet until now. In his work, garden images and colors which loaded special meaning of poet was known as hidden pearls and no research have been made on this work till now. Garden images in poetry are sometimes colorful, light and sometimes dull and dark. These images change with the with the poet's spirit world. We can visualize the garden images like an oil painting. These images drawn by the poet's words, show poet’s mood like a mirror. The colors used in the poem vary with garden images. This change appears with the change of the mental status of the poet. Thus, the poet uses the colors in accordancewith the different tables and his mood. When there are a lively andwarm colors in optimistic tables, dark and dull colors chosen inpessimistic tables. The poet's choice of the colors is not a coincidence.This selectivity included to poetry with different sensations. In his work,Ozansoy has described variety of colors in different gardens.Imagination, imagery and various emotions had been made with oneaccord in his depictions. The colors and portraits of garden form thepoet’s imagination. Colorful memories in the garden which experiencedin a darling moves from poet's imagination to the verses of the poem.Imagination, colors and gardens are described with darling. Theseimageries compose the garden images and semantic change of thecolors. Halit Fahri Ozansoy’un Gülistanlar ve Harabeler adlı şiir kitabı eski harflerle basılmış ancak günümüze kadar Latin harflerine aktarılmamıştır. Bu eserde şairin bahçe imajları ve renklere yüklediği anlamlar saklı inciler gibi gizli kalmış ve günümüze kadar üzerinde inceleme yapılmamıştır. Şiirdeki bahçe imajları bazen renkli, ışıklı ve bazen de donuk ve karanlıktır. Şairin değişen ruh dünyası ile birlikte bu imajlar da değişir. Bah

Relating loop quantum cosmology to loop quantum gravity: symmetric sectors and embeddings

International Nuclear Information System (INIS)

Engle, J

2007-01-01

In this paper we address the meaning of states in loop quantum cosmology (LQC), in the context of loop quantum gravity. First, we introduce a rigorous formulation of an embedding proposed by Bojowald and Kastrup, of LQC states into loop quantum gravity. Then, using certain holomorphic representations, a new class of embeddings, called b-embeddings, are constructed, following the ideas of Engle (2006 Quantum field theory and its symmetry reduction Class. Quantum Gravity 23 2861-94). We exhibit a class of operators preserving each of these embeddings, and show their consistency with the LQC quantization. In the b-embedding case, the classical analogues of these operators separate points in phase space. Embedding at the gauge and diffeomorphism invariant level is discussed briefly in the conclusions

Embedding objects during 3D printing to add new functionalities.

Science.gov (United States)

Yuen, Po Ki

2016-07-01

A novel method for integrating and embedding objects to add new functionalities during 3D printing based on fused deposition modeling (FDM) (also known as fused filament fabrication or molten polymer deposition) is presented. Unlike typical 3D printing, FDM-based 3D printing could allow objects to be integrated and embedded during 3D printing and the FDM-based 3D printed devices do not typically require any post-processing and finishing. Thus, various fluidic devices with integrated glass cover slips or polystyrene films with and without an embedded porous membrane, and optical devices with embedded Corning(®) Fibrance™ Light-Diffusing Fiber were 3D printed to demonstrate the versatility of the FDM-based 3D printing and embedding method. Fluid perfusion flow experiments with a blue colored food dye solution were used to visually confirm fluid flow and/or fluid perfusion through the embedded porous membrane in the 3D printed fluidic devices. Similar to typical 3D printed devices, FDM-based 3D printed devices are translucent at best unless post-polishing is performed and optical transparency is highly desirable in any fluidic devices; integrated glass cover slips or polystyrene films would provide a perfect optical transparent window for observation and visualization. In addition, they also provide a compatible flat smooth surface for biological or biomolecular applications. The 3D printed fluidic devices with an embedded porous membrane are applicable to biological or chemical applications such as continuous perfusion cell culture or biocatalytic synthesis but without the need for any post-device assembly and finishing. The 3D printed devices with embedded Corning(®) Fibrance™ Light-Diffusing Fiber would have applications in display, illumination, or optical applications. Furthermore, the FDM-based 3D printing and embedding method could also be utilized to print casting molds with an integrated glass bottom for polydimethylsiloxane (PDMS) device replication

Microwave de-embedding from theory to applications

CERN Document Server

Crupi, Giovanni

2013-01-01

This groundbreaking book is the first to give an introduction to microwave de-embedding, showing how it is the cornerstone for waveform engineering. The authors of each chapter clearly explain the theoretical concepts, providing a foundation that supports linear and non-linear measurements, modelling and circuit design. Recent developments and future trends in the field are covered throughout, including successful strategies for low-noise and power amplifier design. This book is a must-have for those wishing to understand the full potential of the microwave de-embedding concept to achieve suc

Automatic generation of co-embeddings from relational data with adaptive shaping.

Science.gov (United States)

Mu, Tingting; Goulermas, John Yannis

2013-10-01

In this paper, we study the co-embedding problem of how to map different types of patterns into one common low-dimensional space, given only the associations (relation values) between samples. We conduct a generic analysis to discover the commonalities between existing co-embedding algorithms and indirectly related approaches and investigate possible factors controlling the shapes and distributions of the co-embeddings. The primary contribution of this work is a novel method for computing co-embeddings, termed the automatic co-embedding with adaptive shaping (ACAS) algorithm, based on an efficient transformation of the co-embedding problem. Its advantages include flexible model adaptation to the given data, an economical set of model variables leading to a parametric co-embedding formulation, and a robust model fitting criterion for model optimization based on a quantization procedure. The secondary contribution of this work is the introduction of a set of generic schemes for the qualitative analysis and quantitative assessment of the output of co-embedding algorithms, using existing labeled benchmark datasets. Experiments with synthetic and real-world datasets show that the proposed algorithm is very competitive compared to existing ones.

Feasibility of chemohyperthermia with docetaxel-embedded magnetoliposomes as minimally invasive local treatment for cancer.

Science.gov (United States)

Yoshida, Motohira; Watanabe, Yuji; Sato, Mitsunori; Maehara, Tsunehiro; Aono, Hiromichi; Naohara, Takashi; Hirazawa, Hideyuki; Horiuchi, Atsushi; Yukumi, Shungo; Sato, Koichi; Nakagawa, Hiromichi; Yamamoto, Yuji; Sugishita, Hiroki; Kawachi, Kanji

2010-04-15

Hyperthermia is a minimally invasive approach to cancer treatment, but it is difficult to heat only the tumor without damaging surrounding tissue. To solve this problem, we studied the effectiveness of chemohyperthermia with docetaxel-embedded magnetoliposomes (DMLs) and an applied alternating current (AC) magnetic field. Human MKN45 gastric cancer cells were implanted in the hind limb of Balb-c/nu/nu mice. Various concentrations of docetaxel-embedded DMLs were injected into the tumors and exposed to an AC magnetic field (n = 6, each). For comparison with hyperthermia alone, magnetite-loaded liposome (ML)-injected tumors were exposed to an AC magnetic field. Furthermore, the results of DML without AC treatment and docetaxel diluted into PBS with AC treatment were also compared (n = 10, each). Tumor surface temperature was maintained between 42 and 43 degrees C. Tumor volume was reduced in the DML group with a docetaxel concentration > 56.8 microg/ml, while a docetaxel concentration > 568.5 microg/ml was required for tumor reduction without hyperthermia. Statistically significant differences in tumor volume and survival rate were observed between the DML group exposed to the magnetic field and the other groups. The tumor disappeared in 3 mice in the DML group exposed to the magnetic field; 2 mice survived over 6 months after treatment, whereas all mice of the other groups died by 15 weeks. Histologically, hyperthermia with DML damaged tumor cells and DML diffused homogeneously. To the best of our knowledge, this is the first report to show that hyperthermia using chemotherapeutic agent-embedded magnetoliposomes has an anticancer effect.

Degradation of lindane by a novel embedded bio-nano hybrid system in aqueous environment.

Science.gov (United States)

Salam, Jaseetha Abdul; Das, Nilanjana

2015-03-01

The objective of this study was to evaluate the effect of an embedded bio-nano hybrid system using nanoscale zinc oxide (n-ZnO) and lindane-degrading yeast Candida VITJzN04 for lindane degradation. Nano-embedding of the yeast was done with chemically synthesized n-ZnO particles (50 mg/mL) and was visualized by atomic force microscope (AFM) and scanning electron microscope (SEM). Nanoparticles were embedded substantially on the surfaces of the yeast cells and translocated into the cell cytoplasm without causing any lethal effect to the cell until 50 mg/mL. Lindane (600 mg/L) degradation was studied both in the individual and hybrid system. Rapid reductive-dechlorination of lindane was attained with n-ZnO under illuminated conditions, with the generation of chlorobenzene and benzene as dechlorination products. The bio-nano hybrid was found to be more effective compared to the native yeasts for lindane degradation and resulted in complete removal within 3 days. The kinetic data analysis implied that the half-life of lindane was 9 h for bio-nano hybrid and 28 h for Candida VITJzN04. The enhanced lindane degradation by bio-nano hybrid might be due to increased porosity and permeability of the yeast cell membrane, facilitating the easy entry of lindane into cell cytoplasm and n-ZnO-mediated dechlorination. To the best of our knowledge, this report, for the first time, suggests the use of n-ZnO-mediated dechlorination of lindane and the novel bio-nano hybrid system that reduces the half-life to one third of the time taken by the yeast alone. The embedded bio-nano hybrid system may be exploited as an effective remediation tool for the treatment of lindane-contaminated wastewaters.

Accurate and systematically improvable density functional theory embedding for correlated wavefunctions

International Nuclear Information System (INIS)

Goodpaster, Jason D.; Barnes, Taylor A.; Miller, Thomas F.; Manby, Frederick R.

2014-01-01

We analyze the sources of error in quantum embedding calculations in which an active subsystem is treated using wavefunction methods, and the remainder using density functional theory. We show that the embedding potential felt by the electrons in the active subsystem makes only a small contribution to the error of the method, whereas the error in the nonadditive exchange-correlation energy dominates. We test an MP2 correction for this term and demonstrate that the corrected embedding scheme accurately reproduces wavefunction calculations for a series of chemical reactions. Our projector-based embedding method uses localized occupied orbitals to partition the system; as with other local correlation methods, abrupt changes in the character of the localized orbitals along a reaction coordinate can lead to discontinuities in the embedded energy, but we show that these discontinuities are small and can be systematically reduced by increasing the size of the active region. Convergence of reaction energies with respect to the size of the active subsystem is shown to be rapid for all cases where the density functional treatment is able to capture the polarization of the environment, even in conjugated systems, and even when the partition cuts across a double bond

A Trusted Computing Architecture of Embedded System Based on Improved TPM

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Wang Xiaosheng

2017-01-01

Full Text Available The Trusted Platform Module (TPM currently used by PCs is not suitable for embedded systems, it is necessary to improve existing TPM. The paper proposes a trusted computing architecture with new TPM and the cryptographic system developed by China for the embedded system. The improved TPM consists of the Embedded System Trusted Cryptography Module (eTCM and the Embedded System Trusted Platform Control Module (eTPCM, which are combined and implemented the TPM’s autonomous control, active defense, high-speed encryption/decryption and other function through its internal bus arbitration module and symmetric and asymmetric cryptographic engines to effectively protect the security of embedded system. In our improved TPM, a trusted measurement method with chain model and star type model is used. Finally, the improved TPM is designed by FPGA, and it is used to a trusted PDA to carry out experimental verification. Experiments show that the trusted architecture of the embedded system based on the improved TPM is efficient, reliable and secure.

Isotope geochemistry of fluid inclusions in Permian halite with implications for the isotopic history of ocean water and the origin of saline formation waters

International Nuclear Information System (INIS)

Knauth, L.P.; Beeunas, M.A.

1986-01-01

deltaD and delta 18 O values have been determined for fluid inclusions in 45 samples of Permian halite. The inclusions are enriched in 18 O relative to the meteoric water line but are depleted in D relative to ocean water. Inclusions with the more positive delta-values coincide with the isotopic compositions expected for evaporating sea water which follows a hooked trajectory on a deltaD-delta 18 O diagram. Inclusions with more negative delta-values may represent more highly evaporated sea water but probably reflect synsedimentary or diagenetic mixing to those of a modern evaporite pan to indicate that Permian sea water was isotopically similar to modern sea water. Connate evaporite brines can have negative delta-values because of the probable hooked isotope trajectory of evaporating sea water and/or synsedimentary mixing of evaporite brines with meteoric waters. (author)

Noncommutativity and Duality through the Symplectic Embedding Formalism

Directory of Open Access Journals (Sweden)

Everton M.C. Abreu

2010-07-01

Full Text Available This work is devoted to review the gauge embedding of either commutative and noncommutative (NC theories using the symplectic formalism framework. To sum up the main features of the method, during the process of embedding, the infinitesimal gauge generators of the gauge embedded theory are easily and directly chosen. Among other advantages, this enables a greater control over the final Lagrangian and brings some light on the so-called ''arbitrariness problem''. This alternative embedding formalism also presents a way to obtain a set of dynamically dual equivalent embedded Lagrangian densities which is obtained after a finite number of steps in the iterative symplectic process, oppositely to the result proposed using the BFFT formalism. On the other hand, we will see precisely that the symplectic embedding formalism can be seen as an alternative and an efficient procedure to the standard introduction of the Moyal product in order to produce in a natural way a NC theory. In order to construct a pedagogical explanation of the method to the nonspecialist we exemplify the formalism showing that the massive NC U(1 theory is embedded in a gauge theory using this alternative systematic path based on the symplectic framework. Further, as other applications of the method, we describe exactly how to obtain a Lagrangian description for the NC version of some systems reproducing well known theories. Naming some of them, we use the procedure in the Proca model, the irrotational fluid model and the noncommutative self-dual model in order to obtain dual equivalent actions for these theories. To illustrate the process of noncommutativity introduction we use the chiral oscillator and the nondegenerate mechanics.

Embedding Complementarity in HCI Methods

DEFF Research Database (Denmark)

Nielsen, Janni; Yssing, Carsten; Tweddell Levinsen, Karin

2007-01-01

Differences in cultural contexts constitute differences in cognition, and research has shown that different cultures may use different cognitive tools for perception and reasoning. The cultural embeddings are significant in relation to HCI, because the cultural context is also embedded in the tec......Differences in cultural contexts constitute differences in cognition, and research has shown that different cultures may use different cognitive tools for perception and reasoning. The cultural embeddings are significant in relation to HCI, because the cultural context is also embedded...

Smart Multicore Embedded Systems

DEFF Research Database (Denmark)

This book provides a single-source reference to the state-of-the-art of high-level programming models and compilation tool-chains for embedded system platforms. The authors address challenges faced by programmers developing software to implement parallel applications in embedded systems, where very...... specificities of various embedded systems from different industries. Parallel programming tool-chains are described that take as input parameters both the application and the platform model, then determine relevant transformations and mapping decisions on the concrete platform, minimizing user intervention...... and hiding the difficulties related to the correct and efficient use of memory hierarchy and low level code generation. Describes tools and programming models for multicore embedded systems Emphasizes throughout performance per watt scalability Discusses realistic limits of software parallelization Enables...

Preparation of magnetic nanoparticles embedded in polystyrene microspheres

International Nuclear Information System (INIS)

Nguyen Hoang Hai; Nguyen Hoang Luong; Nguyen Chau; Ngo Quy Tai

2009-01-01

Superparamagnetic particles are widely used for biological applications such as cell separation. The size of the particles is normally in the range of 10 - 20 nm which is much smaller than the size of a cell. Therefore small particles create small force which is not strong enough to separate the cells from solution. Superparamagnetic nanoparticles embedded in Polystyrene microspheres (magnetic beads) are very useful for cell separation. Magnetic beads have been prepared by solvent evaporation of an emulsion. The beads with size of 0.2 μm - 1.0 μm have a saturation magnetization of 10 - 25 emu/g. The change of the amount of surfactants, volatile solvent, magnetic particles resulted to the change of size, magnetic properties of the magnetic beads.

Numerical analysis of the vibroacoustic properties of plates with embedded grids of acoustic black holes.

Science.gov (United States)

Conlon, Stephen C; Fahnline, John B; Semperlotti, Fabio

2015-01-01

The concept of an Acoustic Black Hole (ABH) has been developed and exploited as an approach for passively attenuating structural vibration. The basic principle of the ABH relies on proper tailoring of the structure geometrical properties in order to produce a gradual reduction of the flexural wave speed, theoretically approaching zero. For practical systems the idealized "zero" wave speed condition cannot be achieved so the structural areas of low wave speed are treated with surface damping layers to allow the ABH to approach the idealized dissipation level. In this work, an investigation was conducted to assess the effects that distributions of ABHs embedded in plate-like structures have on both vibration and structure radiated sound, focusing on characterizing and improving low frequency performance. Finite Element and Boundary Element models were used to assess the vibration response and radiated sound power performance of several plate configurations, comparing baseline uniform plates with embedded periodic ABH designs. The computed modal loss factors showed the importance of the ABH unit cell low order modes in the overall vibration reduction effectiveness of the embedded ABH plates at low frequencies where the free plate bending wavelengths are longer than the scale of the ABH.

Communicating embedded systems networks applications

CERN Document Server

Krief, Francine

2013-01-01

Embedded systems become more and more complex and require having some knowledge in various disciplines such as electronics, data processing, telecommunications and networks. Without detailing all the aspects related to the design of embedded systems, this book, which was written by specialists in electronics, data processing and telecommunications and networks, gives an interesting point of view of communication techniques and problems in embedded systems. This choice is easily justified by the fact that embedded systems are today massively communicating and that telecommunications and network

Advances in embedded computer vision

CERN Document Server

Kisacanin, Branislav

2014-01-01

This illuminating collection offers a fresh look at the very latest advances in the field of embedded computer vision. Emerging areas covered by this comprehensive text/reference include the embedded realization of 3D vision technologies for a variety of applications, such as stereo cameras on mobile devices. Recent trends towards the development of small unmanned aerial vehicles (UAVs) with embedded image and video processing algorithms are also examined. The authoritative insights range from historical perspectives to future developments, reviewing embedded implementation, tools, technolog

An Embedded System Dedicated to Intervehicle Communication Applications

Directory of Open Access Journals (Sweden)

Zhou Haiying

2010-01-01

Full Text Available To overcome system latency and network delay is essential for intervehicle communication (IVC applications such as hazard alarming and cooperative driving. This paper proposes a low-cost embedded software system dedicated to such applications. It consists of two basic component layers: an operating system, named HEROS (hybrid event-driven and real-time multitasking operating system, and a communication protocol, named CIVIC (Communication Inter Véhicule Intelligente et Coopérative. HEROS is originally designed for wireless sensor networks (WSNs. It contains a component-based resource-aware kernel and a low-latency tuple-based communication system. Moreover, it provides a configurable event-driven and/or real-time multitasking mechanism for various embedded applications. The CIVIC is an autoconfiguration cooperative IVC protocol. It merges proactive and reactive approaches to speed up and optimize location-based routing discovery with high-mobility nodes. Currently, this embedded system has been implemented and tested. The experiment results show that the new embedded system has low system latency and network delay under the principle of small resource consumption.

Design Methodologies for Secure Embedded Systems

CERN Document Server

Biedermann, Alexander

2011-01-01

Embedded systems have been almost invisibly pervading our daily lives for several decades. They facilitate smooth operations in avionics, automotive electronics, or telecommunication. New problems arise by the increasing employment, interconnection, and communication of embedded systems in heterogeneous environments: How secure are these embedded systems against attacks or breakdowns? Therefore, how can embedded systems be designed to be more secure? And how can embedded systems autonomically react to threats? Facing these questions, Sorin A. Huss is significantly involved in the exploration o

Replacing xylene with n-heptane for paraffin embedding.

Science.gov (United States)

Stockert, J C; López-Arias, B; Del Castillo, P; Romero, A; Blázquez-Castro, A

2012-10-01

In standard histological technique, aromatic solvents such as xylene and toluene are used as clearing agents between ethanol dehydration and paraffin embedding. In addition, these solvents are used for de-waxing paraffin sections. Unfortunately, these solvents are harmful and therefore adequate substitutes would be useful. We suggest the use of n-heptane as a convenient substitute for xylene. Paraffin sections of rat tissues processed with n-heptane and stained with hematoxylin-eosin or Masson's trichrome showed proper embedment, well preserved morphology and excellent staining.

Stability analysis of embedded solitons in the generalized third-order nonlinear Schroedinger equation

International Nuclear Information System (INIS)

Pelinovsky, Dmitry E.; Yang Jianke

2005-01-01

We study the generalized third-order nonlinear Schroedinger (NLS) equation which admits a one-parameter family of single-hump embedded solitons. Analyzing the spectrum of the linearization operator near the embedded soliton, we show that there exists a resonance pole in the left half-plane of the spectral parameter, which explains linear stability, rather than nonlinear semistability, of embedded solitons. Using exponentially weighted spaces, we approximate the resonance pole both analytically and numerically. We confirm in a near-integrable asymptotic limit that the resonance pole gives precisely the linear decay rate of parameters of the embedded soliton. Using conserved quantities, we qualitatively characterize the stable dynamics of embedded solitons

Extending density functional embedding theory for covalently bonded systems.

Science.gov (United States)

Yu, Kuang; Carter, Emily A

2017-12-19

Quantum embedding theory aims to provide an efficient solution to obtain accurate electronic energies for systems too large for full-scale, high-level quantum calculations. It adopts a hierarchical approach that divides the total system into a small embedded region and a larger environment, using different levels of theory to describe each part. Previously, we developed a density-based quantum embedding theory called density functional embedding theory (DFET), which achieved considerable success in metals and semiconductors. In this work, we extend DFET into a density-matrix-based nonlocal form, enabling DFET to study the stronger quantum couplings between covalently bonded subsystems. We name this theory density-matrix functional embedding theory (DMFET), and we demonstrate its performance in several test examples that resemble various real applications in both chemistry and biochemistry. DMFET gives excellent results in all cases tested thus far, including predicting isomerization energies, proton transfer energies, and highest occupied molecular orbital-lowest unoccupied molecular orbital gaps for local chromophores. Here, we show that DMFET systematically improves the quality of the results compared with the widely used state-of-the-art methods, such as the simple capped cluster model or the widely used ONIOM method.

Improved power conversion efficiency of dye-sensitized solar cells using side chain liquid crystal polymer embedded in polymer electrolytes

Energy Technology Data Exchange (ETDEWEB)

Cho, Woosum [Department of Chemistry Education, and Department of Frontier Materials Chemistry, and Institute for Plastic Information and Energy Materials, Pusan National University, Busan 609-735 (Korea, Republic of); Lee, Jae Wook, E-mail: jlee@donga.ac.kr [Department of Chemistry, Dong-A University, Busan 604-714 (Korea, Republic of); Gal, Yeong-Soon [Polymer Chemistry Lab, College of General Education, Kyungil University, Hayang 712-701 (Korea, Republic of); Kim, Mi-Ra, E-mail: mrkim2@pusan.ac.kr [Department of Polymer Science and Engineering, Pusan National University, Busan 609-735 (Korea, Republic of); Jin, Sung Ho, E-mail: shjin@pusan.ac.kr [Department of Chemistry Education, and Department of Frontier Materials Chemistry, and Institute for Plastic Information and Energy Materials, Pusan National University, Busan 609-735 (Korea, Republic of)

2014-02-14

Side chain liquid crystal polymer (SCLCP) embedded in poly(vinylidenefluoride-co-hexafluoropropylene) (PVdF-co-HFP)-based polymer electrolytes (PVdF-co-HFP:side chain liquid crystal polymer (SCLCP)) was prepared for dye-sensitized solar cell (DSSC) application. The polymer electrolytes contained tetrabutylammonium iodide (TBAI), iodine (I{sub 2}), and 8 wt% PVdF-co-HFP in acetonitrile. DSSCs comprised of PVdF-co-HFP:SCLCP-based polymer electrolytes displayed enhanced redox couple reduction and reduced charge recombination in comparison to those of the conventional PVdF-co-HFP-based polymer electrolyte. The significantly increased short-circuit current density (J{sub sc}, 10.75 mA cm{sup −2}) of the DSSCs with PVdF-co-HFP:SCLCP-based polymer electrolytes afforded a high power conversion efficiency (PCE) of 5.32% and a fill factor (FF) of 0.64 under standard light intensity of 100 mW cm{sup −2} irradiation of AM 1.5 sunlight. - Highlights: • We developed the liquid crystal polymer embedded on polymer electrolyte for DSSCs. • We fabricated the highly efficient DSSCs using polymer electrolyte. • The best PCE achieved for P1 is 5.32% using polymer electrolyte.

Improved power conversion efficiency of dye-sensitized solar cells using side chain liquid crystal polymer embedded in polymer electrolytes

International Nuclear Information System (INIS)

Cho, Woosum; Lee, Jae Wook; Gal, Yeong-Soon; Kim, Mi-Ra; Jin, Sung Ho

2014-01-01

Side chain liquid crystal polymer (SCLCP) embedded in poly(vinylidenefluoride-co-hexafluoropropylene) (PVdF-co-HFP)-based polymer electrolytes (PVdF-co-HFP:side chain liquid crystal polymer (SCLCP)) was prepared for dye-sensitized solar cell (DSSC) application. The polymer electrolytes contained tetrabutylammonium iodide (TBAI), iodine (I 2 ), and 8 wt% PVdF-co-HFP in acetonitrile. DSSCs comprised of PVdF-co-HFP:SCLCP-based polymer electrolytes displayed enhanced redox couple reduction and reduced charge recombination in comparison to those of the conventional PVdF-co-HFP-based polymer electrolyte. The significantly increased short-circuit current density (J sc , 10.75 mA cm −2 ) of the DSSCs with PVdF-co-HFP:SCLCP-based polymer electrolytes afforded a high power conversion efficiency (PCE) of 5.32% and a fill factor (FF) of 0.64 under standard light intensity of 100 mW cm −2 irradiation of AM 1.5 sunlight. - Highlights: • We developed the liquid crystal polymer embedded on polymer electrolyte for DSSCs. • We fabricated the highly efficient DSSCs using polymer electrolyte. • The best PCE achieved for P1 is 5.32% using polymer electrolyte

A real-time photogrammetry system based on embedded architecture

Directory of Open Access Journals (Sweden)

S. Y. Zheng

2014-06-01

Full Text Available In order to meet the demand of real-time spatial data processing and improve the online processing capability of photogrammetric system, a kind of real-time photogrammetry method is proposed in this paper. According to the proposed method, system based on embedded architecture is then designed: using FPGA, ARM+DSP and other embedded computing technology to build specialized hardware operating environment, transplanting and optimizing the existing photogrammetric algorithm to the embedded system, and finally real-time photogrammetric data processing is realized. At last, aerial photogrammetric experiment shows that the method can achieve high-speed and stable on-line processing of photogrammetric data. And the experiment also verifies the feasibility of the proposed real-time photogrammetric system based on embedded architecture. It is the first time to realize real-time aerial photogrammetric system, which can improve the online processing efficiency of photogrammetry to a higher level and broaden the application field of photogrammetry.

Synergistically Enhanced Performance of Ultrathin Nanostructured Silicon Solar Cells Embedded in Plasmonically Assisted, Multispectral Luminescent Waveguides

Energy Technology Data Exchange (ETDEWEB)

Lee, Sung-Min; Dhar, Purnim; Chen, Huandong; Montenegro, Angelo; Liaw, Lauren; Kang, Dongseok; Gai, Boju; Benderskii, Alexander V.; Yoon, Jongseung

2017-04-12

Ultrathin silicon solar cells fabricated by anisotropic wet chemical etching of single-crystalline wafer materials represent an attractive materials platform that could provide many advantages for realizing high-performance, low-cost photovoltaics. However, their intrinsically limited photovoltaic performance arising from insufficient absorption of low-energy photons demands careful design of light management to maximize the efficiency and preserve the cost-effectiveness of solar cells. Herein we present an integrated flexible solar module of ultrathin, nanostructured silicon solar cells capable of simultaneously exploiting spectral upconversion and downshifting in conjunction with multispectral luminescent waveguides and a nanostructured plasmonic reflector to compensate for their weak optical absorption and enhance their performance. The 8 μm-thick silicon solar cells incorporating a hexagonally periodic nanostructured surface relief are surface-embedded in layered multispectral luminescent media containing organic dyes and NaYF4:Yb3+,Er3+ nanocrystals as downshifting and upconverting luminophores, respectively, via printing-enabled deterministic materials assembly. The ultrathin nanostructured silicon microcells in the composite luminescent waveguide exhibit strongly augmented photocurrent (~40.1 mA/cm2) and energy conversion efficiency (~12.8%) than devices with only a single type of luminescent species, owing to the synergistic contributions from optical downshifting, plasmonically enhanced upconversion, and waveguided photon flux for optical concentration, where the short-circuit current density increased by ~13.6 mA/cm2 compared with microcells in a nonluminescent medium on a plain silver reflector under a confined illumination.

Electronics for embedded systems

CERN Document Server

Bindal, Ahmet

2017-01-01

This book provides semester-length coverage of electronics for embedded systems, covering most common analog and digital circuit-related issues encountered while designing embedded system hardware. It is written for students and young professionals who have basic circuit theory background and want to learn more about passive circuits, diode and bipolar transistor circuits, the state-of-the-art CMOS logic family and its interface with older logic families such as TTL, sensors and sensor physics, operational amplifier circuits to condition sensor signals, data converters and various circuits used in electro-mechanical device control in embedded systems. The book also provides numerous hardware design examples by integrating the topics learned in earlier chapters. The last chapter extensively reviews the combinational and sequential logic design principles to be able to design the digital part of embedded system hardware.

Global embedding of the Kerr black hole event horizon into hyperbolic 3-space

International Nuclear Information System (INIS)

Gibbons, G. W.; Herdeiro, C. A. R.; Rebelo, C.

2009-01-01

An explicit global and unique isometric embedding into hyperbolic 3-space, H 3 , of an axi-symmetric 2-surface with Gaussian curvature bounded below is given. In particular, this allows the embedding into H 3 of surfaces of revolution having negative, but finite, Gaussian curvature at smooth fixed points of the U(1) isometry. As an example, we exhibit the global embedding of the Kerr-Newman event horizon into H 3 , for arbitrary values of the angular momentum. For this example, considering a quotient of H 3 by the Picard group, we show that the hyperbolic embedding fits in a fundamental domain of the group up to a slightly larger value of the angular momentum than the limit for which a global embedding into Euclidean 3-space is possible. An embedding of the double-Kerr event horizon is also presented, as an example of an embedding that cannot be made global.

Brauer type embedding problems

CERN Document Server

Ledet, Arne

2005-01-01

This monograph is concerned with Galois theoretical embedding problems of so-called Brauer type with a focus on 2-groups and on finding explicit criteria for solvability and explicit constructions of the solutions. The advantage of considering Brauer type embedding problems is their comparatively simple condition for solvability in the form of an obstruction in the Brauer group of the ground field. This book presupposes knowledge of classical Galois theory and the attendant algebra. Before considering questions of reducing the embedding problems and reformulating the solvability criteria, the

Embedded Systems Design with FPGAs

CERN Document Server

Pnevmatikatos, Dionisios; Sklavos, Nicolas

2013-01-01

This book presents methodologies for modern applications of embedded systems design, using field programmable gate array (FPGA) devices.  Coverage includes state-of-the-art research from academia and industry on a wide range of topics, including advanced electronic design automation (EDA), novel system architectures, embedded processors, arithmetic, dynamic reconfiguration and applications. Describes a variety of methodologies for modern embedded systems design;  Implements methodologies presented on FPGAs; Covers a wide variety of applications for reconfigurable embedded systems, including Bioinformatics, Communications and networking, Application acceleration, Medical solutions, Experiments for high energy physics, Astronomy, Aerospace, Biologically inspired systems and Computational fluid dynamics (CFD).

Groundwater connectivity of upland-embedded wetlands in the Prairie Pothole Region

Science.gov (United States)

Neff, Brian; Rosenberry, Donald O.

2018-01-01

Groundwater connections from upland-embedded wetlands to downstream waterbodies remain poorly understood. In principle, water from upland-embedded wetlands situated high in a landscape should flow via groundwater to waterbodies situated lower in the landscape. However, the degree of groundwater connectivity varies across systems due to factors such as geologic setting, hydrologic conditions, and topography. We use numerical models to evaluate the conditions suitable for groundwater connectivity between upland-embedded wetlands and downstream waterbodies in the prairie pothole region of North Dakota (USA). Results show groundwater connectivity between upland-embedded wetlands and other waterbodies is restricted when these wetlands are surrounded by a mounding water table. However, connectivity exists among adjacent upland-embedded wetlands where water–table mounds do not form. In addition, the presence of sand layers greatly facilitates groundwater connectivity of upland-embedded wetlands. Anisotropy can facilitate connectivity via groundwater flow, but only if it becomes unrealistically large. These findings help consolidate previously divergent views on the significance of local and regional groundwater flow in the prairie pothole region.

Test process for the safety-critical embedded software

International Nuclear Information System (INIS)

Sung, Ahyoung; Choi, Byoungju; Lee, Jangsoo

2004-01-01

Digitalization of nuclear Instrumentation and Control (I and C) system requires high reliability of not only hardware but also software. Verification and Validation (V and V) process is recommended for software reliability. But a more quantitative method is necessary such as software testing. Most of software in the nuclear I and C system is safety-critical embedded software. Safety-critical embedded software is specified, verified and developed according to V and V process. Hence two types of software testing techniques are necessary for the developed code. First, code-based software testing is required to examine the developed code. Second, after code-based software testing, software testing affected by hardware is required to reveal the interaction fault that may cause unexpected results. We call the testing of hardware's influence on software, an interaction testing. In case of safety-critical embedded software, it is also important to consider the interaction between hardware and software. Even if no faults are detected when testing either hardware or software alone, combining these components may lead to unexpected results due to the interaction. In this paper, we propose a software test process that embraces test levels, test techniques, required test tasks and documents for safety-critical embedded software. We apply the proposed test process to safety-critical embedded software as a case study, and show the effectiveness of it. (author)

Permutation entropy with vector embedding delays

Science.gov (United States)

Little, Douglas J.; Kane, Deb M.

2017-12-01

Permutation entropy (PE) is a statistic used widely for the detection of structure within a time series. Embedding delay times at which the PE is reduced are characteristic timescales for which such structure exists. Here, a generalized scheme is investigated where embedding delays are represented by vectors rather than scalars, permitting PE to be calculated over a (D -1 ) -dimensional space, where D is the embedding dimension. This scheme is applied to numerically generated noise, sine wave and logistic map series, and experimental data sets taken from a vertical-cavity surface emitting laser exhibiting temporally localized pulse structures within the round-trip time of the laser cavity. Results are visualized as PE maps as a function of embedding delay, with low PE values indicating combinations of embedding delays where correlation structure is present. It is demonstrated that vector embedding delays enable identification of structure that is ambiguous or masked, when the embedding delay is constrained to scalar form.

Research on Face Recognition Based on Embedded System

Directory of Open Access Journals (Sweden)

Hong Zhao

2013-01-01

Full Text Available Because a number of image feature data to store, complex calculation to execute during the face recognition, therefore the face recognition process was realized only by PCs with high performance. In this paper, the OpenCV facial Haar-like features were used to identify face region; the Principal Component Analysis (PCA was employed in quick extraction of face features and the Euclidean Distance was also adopted in face recognition; as thus, data amount and computational complexity would be reduced effectively in face recognition, and the face recognition could be carried out on embedded platform. Finally, based on Tiny6410 embedded platform, a set of embedded face recognition systems was constructed. The test results showed that the system has stable operation and high recognition rate can be used in portable and mobile identification and authentication.

A novel sourceline voltage compensation circuit for embedded NOR flash memory

International Nuclear Information System (INIS)

Zhang Shengbo; Yang Guangjun; Hu Jian; Xiao Jun

2014-01-01

A novel sourceline voltage compensation circuit for program operation in embedded flash memory is presented. With the sourceline voltage compensation circuit, the charge pump can modulate the output voltage according to the number of cells to be programmed with data “0”. So the IR drop on the sourceline decoding path is compensated, and a stable sourceline voltage can be obtained. In order to reduce the power dissipation in program operation, a bit-inversion program circuit is adopted. By using the bit-inversion program circuit, the cells programmed to data “0” are limited to half of the bits of a write data word, thus power dissipation in program operation is greatly reduced. A 1.8-V 8 × 64-kbits embedded NOR flash memory employing the two circuits has been integrated using a GSMC 0.18-μm 4-poly 4-metal CMOS process. (semiconductor integrated circuits)

An integrated compact airborne multispectral imaging system using embedded computer

Science.gov (United States)

Zhang, Yuedong; Wang, Li; Zhang, Xuguo

2015-08-01

An integrated compact airborne multispectral imaging system using embedded computer based control system was developed for small aircraft multispectral imaging application. The multispectral imaging system integrates CMOS camera, filter wheel with eight filters, two-axis stabilized platform, miniature POS (position and orientation system) and embedded computer. The embedded computer has excellent universality and expansibility, and has advantages in volume and weight for airborne platform, so it can meet the requirements of control system of the integrated airborne multispectral imaging system. The embedded computer controls the camera parameters setting, filter wheel and stabilized platform working, image and POS data acquisition, and stores the image and data. The airborne multispectral imaging system can connect peripheral device use the ports of the embedded computer, so the system operation and the stored image data management are easy. This airborne multispectral imaging system has advantages of small volume, multi-function, and good expansibility. The imaging experiment results show that this system has potential for multispectral remote sensing in applications such as resource investigation and environmental monitoring.

The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver

Directory of Open Access Journals (Sweden)

Markus Heine

2014-09-01

Full Text Available Semiconductor quantum dots (QD and superparamagnetic iron oxide nanocrystals (SPIO have exceptional physical properties that are well suited for biomedical applications in vitro and in vivo. For future applications, the direct injection of nanocrystals for imaging and therapy represents an important entry route into the human body. Therefore, it is crucial to investigate biological responses of the body to nanocrystals to avoid harmful side effects. In recent years, we established a system to embed nanocrystals with a hydrophobic oleic acid shell either by lipid micelles or by the amphiphilic polymer poly(maleic anhydride-alt-1-octadecene (PMAOD. The goal of the current study is to investigate the uptake processes as well as pro-inflammatory responses in the liver after the injection of these encapsulated nanocrystals. By immunofluorescence and electron microscopy studies using wild type mice, we show that 30 min after injection polymer-coated nanocrystals are primarily taken up by liver sinusoidal endothelial cells. In contrast, by using wild type, Ldlr-/- as well as Apoe-/- mice we show that nanocrystals embedded within lipid micelles are internalized by Kupffer cells and, in a process that is dependent on the LDL receptor and apolipoprotein E, by hepatocytes. Gene expression analysis of pro-inflammatory markers such as tumor necrosis factor alpha (TNFα or chemokine (C-X-C motif ligand 10 (Cxcl10 indicated that 48 h after injection internalized nanocrystals did not provoke pro-inflammatory pathways. In conclusion, internalized nanocrystals at least in mouse liver cells, namely endothelial cells, Kupffer cells and hepatocytes are at least not acutely associated with potential adverse side effects, underlining their potential for biomedical applications.

A Real-Time Embedded Control System for Electro-Fused Magnesia Furnace

Directory of Open Access Journals (Sweden)

Fang Zheng

2013-01-01

Full Text Available Since smelting process of electro-fused magnesia furnace is a complicated process which has characteristics like complex operation conditions, strong nonlinearities, and strong couplings, traditional linear controller cannot control it very well. Advanced intelligent control strategy is a good solution to this kind of industrial process. However, advanced intelligent control strategy always involves huge programming task and hard debugging and maintaining problems. In this paper, a real-time embedded control system is proposed for the process control of electro-fused magnesia furnace based on intelligent control strategy and model-based design technology. As for hardware, an embedded controller based on an industrial Single Board Computer (SBC is developed to meet industrial field environment demands. As for software, a Linux based on Real-Time Application Interface (RTAI is used as the real-time kernel of the controller to improve its real-time performance. The embedded software platform is also modified to support generating embedded code automatically from Simulink/Stateflow models. Based on the proposed embedded control system, the intelligent embedded control software of electro-fused magnesium furnace can be directly generated from Simulink/Stateflow models. To validate the effectiveness of the proposed embedded control system, hardware-in-the-loop (HIL and industrial field experiments are both implemented. Experiments results show that the embedded control system works very well in both laboratory and industry environments.

Learning optimal embedded cascades.

Science.gov (United States)

Saberian, Mohammad Javad; Vasconcelos, Nuno

2012-10-01

The problem of automatic and optimal design of embedded object detector cascades is considered. Two main challenges are identified: optimization of the cascade configuration and optimization of individual cascade stages, so as to achieve the best tradeoff between classification accuracy and speed, under a detection rate constraint. Two novel boosting algorithms are proposed to address these problems. The first, RCBoost, formulates boosting as a constrained optimization problem which is solved with a barrier penalty method. The constraint is the target detection rate, which is met at all iterations of the boosting process. This enables the design of embedded cascades of known configuration without extensive cross validation or heuristics. The second, ECBoost, searches over cascade configurations to achieve the optimal tradeoff between classification risk and speed. The two algorithms are combined into an overall boosting procedure, RCECBoost, which optimizes both the cascade configuration and its stages under a detection rate constraint, in a fully automated manner. Extensive experiments in face, car, pedestrian, and panda detection show that the resulting detectors achieve an accuracy versus speed tradeoff superior to those of previous methods.

Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes

Directory of Open Access Journals (Sweden)

Higashi Richard M

2008-10-01

Full Text Available Abstract Background The functional status of a cell is expressed in its metabolic activity. We have applied stable isotope tracing methods to determine the differences in metabolic pathways in proliferating Rhabdomysarcoma cells (Rh30 and human primary myocytes in culture. Uniformly 13C-labeled glucose was used as a source molecule to follow the incorporation of 13C into more than 40 marker metabolites using NMR and GC-MS. These include metabolites that report on the activity of glycolysis, Krebs' cycle, pentose phosphate pathway and pyrimidine biosynthesis. Results The Rh30 cells proliferated faster than the myocytes. Major differences in flux through glycolysis were evident from incorporation of label into secreted lactate, which accounts for a substantial fraction of the glucose carbon utilized by the cells. Krebs' cycle activity as determined by 13C isotopomer distributions in glutamate, aspartate, malate and pyrimidine rings was considerably higher in the cancer cells than in the primary myocytes. Large differences were also evident in de novo biosynthesis of riboses in the free nucleotide pools, as well as entry of glucose carbon into the pyrimidine rings in the free nucleotide pool. Specific labeling patterns in these metabolites show the increased importance of anaplerotic reactions in the cancer cells to maintain the high demand for anabolic and energy metabolism compared with the slower growing primary myocytes. Serum-stimulated Rh30 cells showed higher degrees of labeling than serum starved cells, but they retained their characteristic anabolic metabolism profile. The myocytes showed evidence of de novo synthesis of glycogen, which was absent in the Rh30 cells. Conclusion The specific 13C isotopomer patterns showed that the major difference between the transformed and the primary cells is the shift from energy and maintenance metabolism in the myocytes toward increased energy and anabolic metabolism for proliferation in the Rh30 cells

Smart Multicore Embedded Systems

DEFF Research Database (Denmark)

This book provides a single-source reference to the state-of-the-art of high-level programming models and compilation tool-chains for embedded system platforms. The authors address challenges faced by programmers developing software to implement parallel applications in embedded systems, where ve...

Experimental study of reinforced concrete pile caps with external, embedded and partially embedded socket with smooth interface

Directory of Open Access Journals (Sweden)

R. Barros

Full Text Available On Precast concrete structures the column foundation connections can occur through the socket foundation, which can be embedded, partially embedded or external, with socket walls over the pile caps. This paper presents an experimental study about two pile caps reinforced concrete with external, partially embedded and embedded socket submitted to central load, using 1:2 scaled models. In the analyzed models, the smooth interface between the socket walls and column was considered. The results are compared to a reference model that presents monolithic connections between the column and pile cap. It is observed that the ultimate load of pile cap with external sockets has the same magnitude as the reference pile cap, but the ultimate load of models with partially embedded and embedded socket present less magnitude than the reference model.

Identification of Subtype-Specific Prognostic Genes for Early-Stage Lung Adenocarcinoma and Squamous Cell Carcinoma Patients Using an Embedded Feature Selection Algorithm.

Directory of Open Access Journals (Sweden)

Suyan Tian

Full Text Available The existence of fundamental differences between lung adenocarcinoma (AC and squamous cell carcinoma (SCC in their underlying mechanisms motivated us to postulate that specific genes might exist relevant to prognosis of each histology subtype. To test on this research hypothesis, we previously proposed a simple Cox-regression model based feature selection algorithm and identified successfully some subtype-specific prognostic genes when applying this method to real-world data. In this article, we continue our effort on identification of subtype-specific prognostic genes for AC and SCC, and propose a novel embedded feature selection method by extending Threshold Gradient Descent Regularization (TGDR algorithm and minimizing on a corresponding negative partial likelihood function. Using real-world datasets and simulated ones, we show these two proposed methods have comparable performance whereas the new proposal is superior in terms of model parsimony. Our analysis provides some evidence on the existence of such subtype-specific prognostic genes, more investigation is warranted.

Molecular interactions with ice: Molecular embedding, adsorption, detection, and release

Energy Technology Data Exchange (ETDEWEB)

Gibson, K. D.; Langlois, Grant G.; Li, Wenxin; Sibener, S. J., E-mail: s-sibener@uchicago.edu [The James Franck Institute and Department of Chemistry, The University of Chicago, 929 E. 57th Street, Chicago, Illinois 60637 (United States); Killelea, Daniel R. [Department of Chemistry and Biochemistry, Loyola University Chicago, 1068 W. Sheridan Ave., Chicago, Illinois 60660 (United States)

2014-11-14

The interaction of atomic and molecular species with water and ice is of fundamental importance for chemistry. In a previous series of publications, we demonstrated that translational energy activates the embedding of Xe and Kr atoms in the near surface region of ice surfaces. In this paper, we show that inert molecular species may be absorbed in a similar fashion. We also revisit Xe embedding, and further probe the nature of the absorption into the selvedge. CF{sub 4} molecules with high translational energies (≥3 eV) were observed to embed in amorphous solid water. Just as with Xe, the initial adsorption rate is strongly activated by translational energy, but the CF{sub 4} embedding probability is much less than for Xe. In addition, a larger molecule, SF{sub 6}, did not embed at the same translational energies that both CF{sub 4} and Xe embedded. The embedding rate for a given energy thus goes in the order Xe > CF{sub 4} > SF{sub 6}. We do not have as much data for Kr, but it appears to have a rate that is between that of Xe and CF{sub 4}. Tentatively, this order suggests that for Xe and CF{sub 4}, which have similar van der Waals radii, the momentum is the key factor in determining whether the incident atom or molecule can penetrate deeply enough below the surface to embed. The more massive SF{sub 6} molecule also has a larger van der Waals radius, which appears to prevent it from stably embedding in the selvedge. We also determined that the maximum depth of embedding is less than the equivalent of four layers of hexagonal ice, while some of the atoms just below the ice surface can escape before ice desorption begins. These results show that energetic ballistic embedding in ice is a general phenomenon, and represents a significant new channel by which incident species can be trapped under conditions where they would otherwise not be bound stably as surface adsorbates. These findings have implications for many fields including environmental science, trace gas

Efficient Implementation of Solvers for Linear Model Predictive Control on Embedded Devices

DEFF Research Database (Denmark)

Frison, Gianluca; Kwame Minde Kufoalor, D.; Imsland, Lars

2014-01-01

This paper proposes a novel approach for the efficient implementation of solvers for linear MPC on embedded devices. The main focus is to explain in detail the approach used to optimize the linear algebra for selected low-power embedded devices, and to show how the high-performance implementation...

An anti-VEGF ribozyme embedded within the adenoviral VAI sequence inhibits glioblastoma cell angiogenic potential in vitro.

Science.gov (United States)

Ciafrè, Silvia Anna; Niola, Francesco; Wannenes, Francesca; Farace, Maria Giulia

2004-01-01

Vascular endothelial growth factor (VEGF) plays an important role in tumor angiogenesis, where it functions as one of the major angiogenic factors sustaining growth and draining catabolites. In this study, we developed an anti-VEGF ribozyme targeted to the 5' part of human VEGF mRNA. We endowed this ribozyme with an additional feature expected to improve its activity in vivo, by cloning it into a VAI transcriptional cassette. VAI is originally part of the adenovirus genome, and is characterized by high transcription rates, good stability due to its strong secondary structure and cytoplasmic localization. Transfection of U87 human glioblastoma cells with plasmid vectors encoding for this ribozyme resulted in a strong (-56%) reduction of VEGF secreted in the extracellular medium, indicating a good biological activity of the ribozyme. Moreover, this reduction in VEGF secretion had the important functional consequence of drastically diminishing the formation of tube-like structures of human umbilical vascular endothelial cells in a Matrigel in vitro angiogenesis assay. In conclusion, our VAI-embedded anti-VEGF ribozyme is a good inhibitor of angiogenesis in vitro, in a glioblastoma cell context. Thus, it may represent a useful tool for future applications in vivo, for antiangiogenic gene therapy of glioblastoma and of highly vascularized tumors. Copyright 2004 S. Karger AG, Basel

On-Road Driver Monitoring System Based on a Solar-Powered In-Vehicle Embedded Platform

OpenAIRE

Yen-Lin Chen; Chao-Wei Yu; Zi-Jie Chien; Chin-Hsuan Liu; Hsin-Han Chiang

2014-01-01

This study presents an on-road driver monitoring system, which is implemented on a stand-alone in-vehicle embedded system and driven by effective solar cells. The driver monitoring function is performed by an efficient eye detection technique. Through the driver’s eye movements captured from the camera, the attention states of the driver can be determined and any fatigue states can be avoided. This driver monitoring technique is implemented on a low-power embedded in-vehicle platform. Besides...

A novel 2 T P-channel nano-crystal memory for low power/high speed embedded NVM applications

International Nuclear Information System (INIS)

Zhang Junyu; Wang Yong; Liu Jing; Zhang Manhong; Xu Zhongguang; Huo Zongliang; Liu Ming

2012-01-01

We introduce a novel 2 T P-channel nano-crystal memory structure for low power and high speed embedded non-volatile memory (NVM) applications. By using the band-to-band tunneling-induced hot-electron (BTBTIHE) injection scheme, both high-speed and low power programming can be achieved at the same time. Due to the use of a select transistor, the 'erased states' can be set to below 0 V, so that the periphery HV circuit (high-voltage generating and management) and read-out circuit can be simplified. Good memory cell performance has also been achieved, including a fast program/erase (P/E) speed (a 1.15 V memory window under 10 μs program pulse), an excellent data retention (only 20% charge loss for 10 years). The data shows that the device has strong potential for future embedded NVM applications. (semiconductor devices)

Poincare ball embeddings of the optical geometry

International Nuclear Information System (INIS)

Abramowicz, M A; Bengtsson, I; Karas, V; Rosquist, K

2002-01-01

It is shown that the optical geometry of the Reissner-Nordstroem exterior metric can be embedded in a hyperbolic space all the way down to its outer horizon. The adopted embedding procedure removes a breakdown of flat-space embeddings which occurs outside the horizon, at and below the Buchdahl-Bondi limit (R/M=9/4 in the Schwarzschild case). In particular, the horizon can be captured in the optical geometry embedding diagram. Moreover, by using the compact Poincare ball representation of the hyperbolic space, the embedding diagram can cover the whole extent of radius from spatial infinity down to the horizon. Attention is drawn to the advantages of such embeddings in an appropriately curved space: this approach gives compact embeddings and it clearly distinguishes the case of an extremal black hole from a non-extremal one in terms of the topology of the embedded horizon

Homomorphic embeddings in n-groups

Directory of Open Access Journals (Sweden)

Mona Cristescu

2013-06-01

Full Text Available We prove that an cancellative n-groupoid A can be homotopic embedded in an n-group if and only if in A are satisfied all n-ary Malcev conditions. Now we shall prove that in the presence of associative law we obtain homomorphic embeddings. Furthermore, if A has a lateral identity a such embeddings is assured by a subset of n-ary Malcev conditions - unary Malcev conditions.

Asymmetrical and symmetrical embedded Z-source inverters

DEFF Research Database (Denmark)

Gao, F.; Loh, P.C.; Li, D.

2011-01-01

ends, which indirectly translates to a lowering of overall system cost. These noted advantages are indeed appropriate for applications like photovoltaic and fuel cell energy harnessing, and have already been confirmed in simulation and experimentally using a laboratory-implemented inverter prototype.......This study presents two types of embedded Z-source inverters with each type further divided into asymmetrical and symmetrical realisations. Being different from their traditional counterparts, the presented inverters have their dc sources inserted within their X-shaped impedance networks so...

Implementing Explicit and Finding Implicit Sharing in Embedded DSLs

Directory of Open Access Journals (Sweden)

Oleg Kiselyov

2011-09-01

Full Text Available Aliasing, or sharing, is prominent in many domains, denoting that two differently-named objects are in fact identical: a change in one object (memory cell, circuit terminal, disk block is instantly reflected in the other. Languages for modelling such domains should let the programmer explicitly define the sharing among objects or expressions. A DSL compiler may find other identical expressions and share them, implicitly. Such common subexpression elimination is crucial to the efficient implementation of DSLs. Sharing is tricky in embedded DSL, since host aliasing may correspond to copying of the underlying objects rather than their sharing. This tutorial summarizes discussions of implementing sharing in Haskell DSLs for automotive embedded systems and hardware description languages. The technique has since been used in a Haskell SAT solver and the DSL for music synthesis. We demonstrate the embedding in pure Haskell of a simple DSL with a language form for explicit sharing. The DSL also has implicit sharing, implemented via hash-consing. Explicit sharing greatly speeds up hash-consing. The seemingly imperative nature of hash-consing is hidden beneath a simple combinator language. The overall implementation remains pure functional and easy to reason about.

Improved Secret Image Sharing Scheme in Embedding Capacity without Underflow and Overflow.

Science.gov (United States)

Pang, Liaojun; Miao, Deyu; Li, Huixian; Wang, Qiong

2015-01-01

Computational secret image sharing (CSIS) is an effective way to protect a secret image during its transmission and storage, and thus it has attracted lots of attentions since its appearance. Nowadays, it has become a hot topic for researchers to improve the embedding capacity and eliminate the underflow and overflow situations, which is embarrassing and difficult to deal with. The scheme, which has the highest embedding capacity among the existing schemes, has the underflow and overflow problems. Although the underflow and overflow situations have been well dealt with by different methods, the embedding capacities of these methods are reduced more or less. Motivated by these concerns, we propose a novel scheme, in which we take the differential coding, Huffman coding, and data converting to compress the secret image before embedding it to further improve the embedding capacity, and the pixel mapping matrix embedding method with a newly designed matrix is used to embed secret image data into the cover image to avoid the underflow and overflow situations. Experiment results show that our scheme can improve the embedding capacity further and eliminate the underflow and overflow situations at the same time.

Singular interactions supported by embedded curves

International Nuclear Information System (INIS)

Kaynak, Burak Tevfik; Turgut, O Teoman

2012-01-01

In this work, singular interactions supported by embedded curves on Riemannian manifolds are discussed from a more direct and physical perspective, via the heat kernel approach. We show that the renormalized problem is well defined, the ground state is finite and the corresponding wavefunction is positive. The renormalization group invariance of the model is also discussed. (paper)

Characterization of Fetal Keratinocytes, Showing Enhanced Stem Cell-Like Properties: A Potential Source of Cells for Skin Reconstruction

Directory of Open Access Journals (Sweden)

Kenneth K.B. Tan

2014-08-01

Full Text Available Epidermal stem cells have been in clinical application as a source of culture-generated grafts. Although applications for such cells are increasing due to aging populations and the greater incidence of diabetes, current keratinocyte grafting technology is limited by immunological barriers and the time needed for culture amplification. We studied the feasibility of using human fetal skin cells for allogeneic transplantation and showed that fetal keratinocytes have faster expansion times, longer telomeres, lower immunogenicity indicators, and greater clonogenicity with more stem cell indicators than adult keratinocytes. The fetal cells did not induce proliferation of T cells in coculture and were able to suppress the proliferation of stimulated T cells. Nevertheless, fetal keratinocytes could stratify normally in vitro. Experimental transplantation of fetal keratinocytes in vivo seeded on an engineered plasma scaffold yielded a well-stratified epidermal architecture and showed stable skin regeneration. These results support the possibility of using fetal skin cells for cell-based therapeutic grafting.

Do We Already have Samples of CERES H Chondrite Haliites and the CERES-HEBE Link

Science.gov (United States)

Fries, Marc D.; Messenger, S.; Steele, A.; Zolensky, M.

2013-01-01

We investigate the hypothesis that halite grains in the brecciated H chondrites Zag and Monahans originate from Ceres. Evidence includes mineralogy of the halites consistent with formation on a large, carbonaceous, aqueously active body close to the H chondrite parent body >4 Ga ago. Evidence also includes orbital simularities between 1 Ceres and the purported H chondrite parent body (HPB) 6 Hebe, possibly facilitating a gentle transfer between the bodies. Halite grains in the Monahans and Zag Hchondrites are exogenous to the H chondrite parent body and were transported to the HPB >4 Ga ago. Examination of minerals and carboanceous materials entrained within the halites shows that the halite parent body (HaPB) is consistent with a carbonaceous body [1]. It is probably a large body due to the variety of entrained carbonaceous materials which probably accreted from multiple sources. The halite grains contain intact, HaPB-origin, ancient fluid inclusions indicating that transfer between the HaPB and the HPB was a gentle process resulting in a ?T of 4 Ga ago. Additional dynamical factors need to be investigated. A combination of factors suggests Ceres as the HaPB. It is a carbonaceous body with suggestions of past aqueous activity [9], which is consistent with the mineral species found in H chondrite halites. Ceres is also a large body capable of accreting the range of carbonaceous materials noted [5]. It is relatively near to purported HPB Hebe, which is required to preserve halite fluid inclusions. The above evidence defines a hypothesized scenario featuring ejection of halite grains from Ceres onto Hebe. Halite was then entrained in H-chondrite near-surface breccias and ejected from Hebe for transport to Earth.

Exchange bias of Ni nanoparticles embedded in an antiferromagnetic IrMn matrix

International Nuclear Information System (INIS)

Kuerbanjiang, Balati; Herr, Ulrich; Wiedwald, Ulf; Haering, Felix; Ziemann, Paul; Biskupek, Johannes; Kaiser, Ute

2013-01-01

The magnetic properties of Ni nanoparticles (Ni-NPs) embedded in an antiferromagnetic IrMn matrix were investigated. The Ni-NPs of 8.4 nm mean diameter were synthesized by inert gas aggregation. In a second processing step, the Ni-NPs were in situ embedded in IrMn films or SiO x films under ultrahigh vacuum (UHV) conditions. Findings showed that Ni-NPs embedded in IrMn have an exchange bias field H EB = 821 Oe at 10 K, and 50 Oe at 300 K. The extracted value of the exchange energy density is 0.06 mJ m −2 at 10 K, which is in good accordance with the results from multilayered thin film systems. The Ni-NPs embedded in SiO x did not show exchange bias. As expected for this particle size, they are superparamagnetic at T = 300 K. A direct comparison of the Ni-NPs embedded in IrMn or SiO x reveals an increase of the blocking temperature from 210 K to around 400 K. The coercivity of the Ni-NPs exchange coupled to the IrMn matrix at 10 K is 8 times larger than the value for Ni-NPs embedded in SiO x . We studied time-dependent remanent magnetization at different temperatures. The relaxation behavior is described by a magnetic viscosity model which reflects a rather flat distribution of energy barriers. Furthermore, we investigated the effects of different field cooling processes on the magnetic properties of the embedded Ni-NPs. Exchange bias values fit to model calculations which correlate the contribution of the antiferromagnetic IrMn matrix to its grain size. (paper)

Embedded Linux projects using Yocto project cookbook

CERN Document Server

González, Alex

2015-01-01

If you are an embedded developer learning about embedded Linux with some experience with the Yocto project, this book is the ideal way to become proficient and broaden your knowledge with examples that are immediately applicable to your embedded developments. Experienced embedded Yocto developers will find new insight into working methodologies and ARM specific development competence.

Highly sensitive KRAS mutation detection from formalin-fixed paraffin-embedded biopsies and circulating tumour cells using wild-type blocking polymerase chain reaction and Sanger sequencing.

Science.gov (United States)

Huang, Meggie Mo Chao; Leong, Sai Mun; Chua, Hui Wen; Tucker, Steven; Cheong, Wai Chye; Chiu, Lily; Li, Mo-Huang; Koay, Evelyn Siew-Chuan

2014-08-01

Among patients with colorectal cancer (CRC), KRAS mutations were reported to occur in 30-51 % of all cases. CRC patients with KRAS mutations were reported to be non-responsive to anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MoAb) treatment in many clinical trials. Hence, accurate detection of KRAS mutations would be critical in guiding the use of anti-EGFR MoAb therapies in CRC. In this study, we carried out a detailed investigation of the efficacy of a wild-type (WT) blocking real-time polymerase chain reaction (PCR), employing WT KRAS locked nucleic acid blockers, and Sanger sequencing, for KRAS mutation detection in rare cells. Analyses were first conducted on cell lines to optimize the assay protocol which was subsequently applied to peripheral blood and tissue samples from patients with CRC. The optimized assay provided a superior sensitivity enabling detection of as little as two cells with mutated KRAS in the background of 10(4) WT cells (0.02 %). The feasibility of this assay was further investigated to assess the KRAS status of 45 colorectal tissue samples, which had been tested previously, using a conventional PCR sequencing approach. The analysis showed a mutational discordance between these two methods in 4 of 18 WT cases. Our results present a simple, effective, and robust method for KRAS mutation detection in both paraffin embedded tissues and circulating tumour cells, at single-cell level. The method greatly enhances the detection sensitivity and alleviates the need of exhaustively removing co-enriched contaminating lymphocytes.

Lossless Data Embedding—New Paradigm in Digital Watermarking

Directory of Open Access Journals (Sweden)

Jessica Fridrich

2002-02-01

Full Text Available One common drawback of virtually all current data embedding methods is the fact that the original image is inevitably distorted due to data embedding itself. This distortion typically cannot be removed completely due to quantization, bit-replacement, or truncation at the grayscales 0 and 255. Although the distortion is often quite small and perceptual models are used to minimize its visibility, the distortion may not be acceptable for medical imagery (for legal reasons or for military images inspected under nonstandard viewing conditions (after enhancement or extreme zoom. In this paper, we introduce a new paradigm for data embedding in images (lossless data embedding that has the property that the distortion due to embedding can be completely removed from the watermarked image after the embedded data has been extracted. We present lossless embedding methods for the uncompressed formats (BMP, TIFF and for the JPEG format. We also show how the concept of lossless data embedding can be used as a powerful tool to achieve a variety of nontrivial tasks, including lossless authentication using fragile watermarks, steganalysis of LSB embedding, and distortion-free robust watermarking.

Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells.

Science.gov (United States)

Honda, Yumi; Tanigawa, Hiroki; Harada, Miho; Fukushima, Satoshi; Masuguchi, Shinichi; Ishihara, Tsuyoshi; Ihn, Hironobu; Iyama, Ken-ichi

2013-05-01

Herein, we report a 63-year-old man presenting with hidradenocarcinoma showing prominent mucinous and squamous differentiation on his back. The tumor was dermal-based, solid and cystic. Tumor cells with squamous differentiation and with keratin pearl formation were identified predominantly in the superficial dermis, and mucinous cells were identified principally in the cystic lesion in the deep dermis. Interestingly, the additional feature of pagetoid cells was identified in the overlying epidermis. Both the mucinous cells in hidradenocarcinoma and pagetoid cells had intracytoplasmic mucin; however, they had different histopathologic findings and immunophenotypes. Mucinous cells in hidradenocarcinoma had small nuclei and abundant intracytoplasmic mucin presenting goblet cells with low rate of positive immunostaining for p53 and Ki67. In contrast, pagetoid cells had larger nuclei with less intracytoplasmic mucin. Both p53- and Ki67-positive cells were increased in pagetoid cells. Additionally, mucinous cells in hidradenocarcinoma were MUC1(+)/MUC2(-)/MUC5AC(+)/MUC6(+), but pagetoid cells were MUC1(+; focal)/MUC2(-)/MUC5AC(-)/MUC6(+; focal). The derivation of pagetoid cells is unclear; however, the localized small region of pagetoid cells over the hidradenocarcinoma in the present case may suggest a common histogenesis of these two malignant neoplasms. Copyright © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.

Mechanical properties of nickel-coated single-walled carbon nanotubes and their embedded gold matrix composites

International Nuclear Information System (INIS)

Song Haiyang; Zha Xinwei

2010-01-01

The effects of nickel coating on the mechanical behaviors of armchair single-walled carbon nanotubes (SWCNTs) and their embedded gold matrix composites under axial tension are investigated using molecular dynamics (MD) simulation method. The results show that the Young's moduli and tensile strength of SWCNTs obviously decrease after nickel coating. For armchair SWCNTs, the decreased ratio of the Young's moduli of SWCNTs with smaller radius is larger than that of SWCNTs with larger radius. A comparison is made between the response to Young's modulus of a composite with parallel embedded nanotube and the response of a composite with vertically embedded nanotube. The results show that the uncoated SWCNT can enhance the Young's modulus of composite under the condition of parallel embedment, but such improvement disappears under the condition of vertical embedment because the interaction between SWCNT and gold matrix is too weak for effective load transfer. However, the nickel-coated SWCNT can indeed significantly improve the composite behavior.

Embedding of reactor wastes in plastic resins

International Nuclear Information System (INIS)

1979-01-01

STEAG Kernenergie GmbH is so far the only firm commercially to condition radioactive bead ion exchange resins by embedding in polystyrene resins. The objective of the work reported here was to study and develop methods for immobilization of other reactor wastes in plastic resins. Comparison studies on high quality cement however showed favourable results for cement with respect to process safety and economy. For this reason STEAG interrupted its work in the field of resin embedding after about one year. The work carried out during this period is surveyed in this report, which includes a comprehensive literature study on reactor wastes and their solidification in plastic resins as well as on regulations with regard to radioactive waste disposal in the member states of the European Communities

Heteromeric Slick/Slack K+ channels show graded sensitivity to cell volume changes.

Science.gov (United States)

Tejada, Maria A; Hashem, Nadia; Calloe, Kirstine; Klaerke, Dan A

2017-01-01

Slick and Slack high-conductance K+ channels are found in the CNS, kidneys, pancreas, among other organs, where they play an important role in cell excitability as well as in ion transport processes. They are both activated by Na+ and Cl- but show a differential regulation by cell volume changes. Slick has been shown to be regulated by cell volume changes, whereas Slack is insensitive. α-subunits of these channels form homomeric as well as heteromeric channels. It is the aim of this work to explore whether the subunit composition of the Slick/Slack heteromeric channel affects the response to osmotic challenges. In order to provide with the adequate water permeability to the cell membrane of Xenopus laevis oocytes, mRNA of aquaporin 1 was co-expressed with homomeric or heteromeric Slick and Slack α-subunits. Oocytes were superfused with hypotonic or hypertonic buffers and changes in currents were measured by two-electrode voltage clamp. This work presents the first heteromeric K+ channel with a characteristic graded sensitivity to small and fast changes in cell volume. Our results show that the cell volume sensitivity of Slick/Slack heteromeric channels is dependent on the number of volume sensitive Slick α-subunits in the tetrameric channels, giving rise to graded cell volume sensitivity. Regulation of the subunit composition of a channel may constitute a novel mechanism to determine volume sensitivity of cells.

Tensor Train Neighborhood Preserving Embedding

Science.gov (United States)

Wang, Wenqi; Aggarwal, Vaneet; Aeron, Shuchin

2018-05-01

In this paper, we propose a Tensor Train Neighborhood Preserving Embedding (TTNPE) to embed multi-dimensional tensor data into low dimensional tensor subspace. Novel approaches to solve the optimization problem in TTNPE are proposed. For this embedding, we evaluate novel trade-off gain among classification, computation, and dimensionality reduction (storage) for supervised learning. It is shown that compared to the state-of-the-arts tensor embedding methods, TTNPE achieves superior trade-off in classification, computation, and dimensionality reduction in MNIST handwritten digits and Weizmann face datasets.

Micro-precise spatiotemporal delivery system embedded in 3D printing for complex tissue regeneration.

Science.gov (United States)

Tarafder, Solaiman; Koch, Alia; Jun, Yena; Chou, Conrad; Awadallah, Mary R; Lee, Chang H

2016-04-25

Three dimensional (3D) printing has emerged as an efficient tool for tissue engineering and regenerative medicine, given its advantages for constructing custom-designed scaffolds with tunable microstructure/physical properties. Here we developed a micro-precise spatiotemporal delivery system embedded in 3D printed scaffolds. PLGA microspheres (μS) were encapsulated with growth factors (GFs) and then embedded inside PCL microfibers that constitute custom-designed 3D scaffolds. Given the substantial difference in the melting points between PLGA and PCL and their low heat conductivity, μS were able to maintain its original structure while protecting GF's bioactivities. Micro-precise spatial control of multiple GFs was achieved by interchanging dispensing cartridges during a single printing process. Spatially controlled delivery of GFs, with a prolonged release, guided formation of multi-tissue interfaces from bone marrow derived mesenchymal stem/progenitor cells (MSCs). To investigate efficacy of the micro-precise delivery system embedded in 3D printed scaffold, temporomandibular joint (TMJ) disc scaffolds were fabricated with micro-precise spatiotemporal delivery of CTGF and TGFβ3, mimicking native-like multiphase fibrocartilage. In vitro, TMJ disc scaffolds spatially embedded with CTGF/TGFβ3-μS resulted in formation of multiphase fibrocartilaginous tissues from MSCs. In vivo, TMJ disc perforation was performed in rabbits, followed by implantation of CTGF/TGFβ3-μS-embedded scaffolds. After 4 wks, CTGF/TGFβ3-μS embedded scaffolds significantly improved healing of the perforated TMJ disc as compared to the degenerated TMJ disc in the control group with scaffold embedded with empty μS. In addition, CTGF/TGFβ3-μS embedded scaffolds significantly prevented arthritic changes on TMJ condyles. In conclusion, our micro-precise spatiotemporal delivery system embedded in 3D printing may serve as an efficient tool to regenerate complex and inhomogeneous tissues.

Feature-based component model for design of embedded systems

Science.gov (United States)

Zha, Xuan Fang; Sriram, Ram D.

2004-11-01

An embedded system is a hybrid of hardware and software, which combines software's flexibility and hardware real-time performance. Embedded systems can be considered as assemblies of hardware and software components. An Open Embedded System Model (OESM) is currently being developed at NIST to provide a standard representation and exchange protocol for embedded systems and system-level design, simulation, and testing information. This paper proposes an approach to representing an embedded system feature-based model in OESM, i.e., Open Embedded System Feature Model (OESFM), addressing models of embedded system artifacts, embedded system components, embedded system features, and embedded system configuration/assembly. The approach provides an object-oriented UML (Unified Modeling Language) representation for the embedded system feature model and defines an extension to the NIST Core Product Model. The model provides a feature-based component framework allowing the designer to develop a virtual embedded system prototype through assembling virtual components. The framework not only provides a formal precise model of the embedded system prototype but also offers the possibility of designing variation of prototypes whose members are derived by changing certain virtual components with different features. A case study example is discussed to illustrate the embedded system model.

Polarizable Density Embedding

DEFF Research Database (Denmark)

Olsen, Jógvan Magnus Haugaard; Steinmann, Casper; Ruud, Kenneth

2015-01-01

We present a new QM/QM/MM-based model for calculating molecular properties and excited states of solute-solvent systems. We denote this new approach the polarizable density embedding (PDE) model and it represents an extension of our previously developed polarizable embedding (PE) strategy. The PDE...... model is a focused computational approach in which a core region of the system studied is represented by a quantum-chemical method, whereas the environment is divided into two other regions: an inner and an outer region. Molecules belonging to the inner region are described by their exact densities...

CO oxidation catalyzed by Pt-embedded graphene: A first-principles investigation

KAUST Repository

Liu, Xin; Sui, Yanhui; Duan, Ting; Meng, Changong; Han, Yu

2014-01-01

We addressed the potential catalytic role of Pt-embedded graphene in CO oxidation by first-principles-based calculations. We showed that the combination of highly reactive Pt atoms and defects over graphene makes the Pt-embedded graphene a superior mono-dispersed atomic catalyst for CO oxidation. The binding energy of a single Pt atom onto monovacancy defects is up to -7.10 eV, which not only ensures the high stability of the embedded Pt atom, but also vigorously excludes the possibility of diffusion and aggregation of embedded Pt atoms. This strong interfacial interaction also tunes the energy level of Pt-d states for the activation of O2, and promotes the formation and dissociation of the peroxide-like intermediate. The catalytic cycle of CO oxidation is initiated through the Langmuir-Hinshelwood mechanism, with the formation of a peroxide-like intermediate by the coadsorbed CO and O2, by the dissociation of which the CO2 molecule and an adsorbed O atom are formed. Then, another gaseous CO will react with the remnant O atom and make the embedded Pt atom available for the subsequent reaction. The calculated energy barriers for the formation and dissociation of the peroxide-like intermediate are as low as 0.33 and 0.15 eV, respectively, while that for the regeneration of the embedded Pt atom is 0.46 eV, indicating the potential high catalytic performance of Pt-embedded graphene for low temperature CO oxidation.

TaPT: Temperature-Aware Dynamic Cache Optimization for Embedded Systems

Directory of Open Access Journals (Sweden)

Tosiron Adegbija

2017-12-01

Full Text Available Embedded systems have stringent design constraints, which has necessitated much prior research focus on optimizing energy consumption and/or performance. Since embedded systems typically have fewer cooling options, rising temperature, and thus temperature optimization, is an emergent concern. Most embedded systems only dissipate heat by passive convection, due to the absence of dedicated thermal management hardware mechanisms. The embedded system’s temperature not only affects the system’s reliability, but can also affect the performance, power, and cost. Thus, embedded systems require efficient thermal management techniques. However, thermal management can conflict with other optimization objectives, such as execution time and energy consumption. In this paper, we focus on managing the temperature using a synergy of cache optimization and dynamic frequency scaling, while also optimizing the execution time and energy consumption. This paper provides new insights on the impact of cache parameters on efficient temperature-aware cache tuning heuristics. In addition, we present temperature-aware phase-based tuning, TaPT, which determines Pareto optimal clock frequency and cache configurations for fine-grained execution time, energy, and temperature tradeoffs. TaPT enables autonomous system optimization and also allows designers to specify temperature constraints and optimization priorities. Experiments show that TaPT can effectively reduce execution time, energy, and temperature, while imposing minimal hardware overhead.

Preparation, Characterization and Analysis of Fouling Mechanisms of TiO2- Embedded PVDF Membranes

Directory of Open Access Journals (Sweden)

Yoones Jafarzadeh

2017-01-01

Full Text Available Titanium dioxide (TiO2-embedded polyvinylidene fluoride (PVDF mixed matrix membranes were prepared through a nonsolvent induced phase separation (NIPS method. The structure of the membranes was characterized by FESEM, EDX, water drop contact angle measurement, pure water flux and mean pore radius analysis. The results showed that the prepared membranes had asymmetric structures with macro-voids and the presence of TiO2 nanoparticles increased the size of macro-voids. Moreover, pure water flux increased from 41 kg/m2h to 162 kg/m2h the content of TiO2 nanoparticles increased from 1 wt% to 5 wt% as embedded membrane. The contact angle dropped from 100° for 1 wt% TiO2- embedded membrane to 69° for 5 wt% TiO2-embedded membrane, showing that the hydrophilicity of membranes increased by addition of inorganic TiO2 nanoparticles. The fouling behavior oftheprepared mixed matrix membranes was studied in filtration process of 1% humic acid solution. The results showed that fouling resistance of the membranes increased with higher content of TiO2 nanoparticles. The results of classic fouling modeling of membranes showed that for 2 and 5 wt% TiO2-embedded membranes the best fit of the data occurred with the intermediate blockage model whereas cake formation model was the dominant mechanism for other membranes. Moreover, the analysis of fouling mechanisms by combined models showed that cake filtration-intermediate blockage model was in good agreement with the experimental data for all membranes. Finally, the results showed that the rejection of membranes increased with the addition of TiO2 nanoparticles, and then decreased.

Theoretical analysis of enhanced light output from a GaN light emitting diode with an embedded photonic crystal

International Nuclear Information System (INIS)

Wen Feng; Liu Deming; Huang Lirong

2010-01-01

The enhancement of the light output of an embedded photonic crystal light emitting diode is investigated based on the finite-difference time-domain modeling. The embedded photonic crystal (PC) lattice type, multi-layer embedded PC, distance between the multiple quantum well and the embedded PC are studied. It is found that the embedded one dimensional PC can act as well as embedded two dimensional PCs. The emitted light flux in the up direction can be increased by a new kind of multi-layer embedded PC. Also, we show that the light output in the up direction for the LED with both surfaces and embedded PC could be as high as five times that of a conventional LED. (semiconductor devices)

Theoretical analysis of enhanced light output from a GaN light emitting diode with an embedded photonic crystal

Energy Technology Data Exchange (ETDEWEB)

Wen Feng; Liu Deming; Huang Lirong, E-mail: hlr5649@163.co [Wuhan National Laboratory for Optoelectronics, College of Opto-Electronics Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China)

2010-10-15

The enhancement of the light output of an embedded photonic crystal light emitting diode is investigated based on the finite-difference time-domain modeling. The embedded photonic crystal (PC) lattice type, multi-layer embedded PC, distance between the multiple quantum well and the embedded PC are studied. It is found that the embedded one dimensional PC can act as well as embedded two dimensional PCs. The emitted light flux in the up direction can be increased by a new kind of multi-layer embedded PC. Also, we show that the light output in the up direction for the LED with both surfaces and embedded PC could be as high as five times that of a conventional LED. (semiconductor devices)

Comprehensive investigation of core-shell dimer nanoparticles size, distance and thicknesses on performance of a hybrid organic-inorganic halide perovskite solar cell

Science.gov (United States)

Heidarzadeh, Hamid

2018-03-01

Significant performance enhancement in an ultrathin perovskite (CH3NH3PbI3) solar cell is done using plasmonic embedded core–shell dimer nanoparticles. Three-dimensional finite difference time-domain (FDTD) method is used. A perovskite absorber with a volume of 400 × 400 × 200 nm3 is considered. At first, a cell with one embedded nanoparticle is simulated. Absorptance of CH3NH3PbI3 absorber and gold nanoparticle are obtained. An optimization is done. Then a cell with embedded dimer nanoparticles is evaluated. The results show higher photocurrent enhancement for that in compared to a cell with one embedded nanoparticle. To further photocurrent enhancement, gold-SiO2 core–shell nanoparticles are used. Photocurrents of 23.37 mA cm‑2, 23.3 mA cm‑2, 22.5 mA cm‑2 and 21.47 mA cm‑2 are obtained for a cell with two embedded core–shell nanoparticles with core radius of 60 nm and shell thickness of 2 nm, 5 nm, 10 nm and 20 nm, respectively. It is important to mention that the photocurrent is 17.9 mA cm‑2 for reference cell and 19.8 mA cm‑2 for a cell with one embedded nanoparticle. Higher photocurrent is due to the near-field plasmonic effect.

Gas expulsion in highly substructured embedded star clusters

Science.gov (United States)

Farias, J. P.; Fellhauer, M.; Smith, R.; Domínguez, R.; Dabringhausen, J.

2018-06-01

We investigate the response of initially substructured, young, embedded star clusters to instantaneous gas expulsion of their natal gas. We introduce primordial substructure to the stars and the gas by simplistically modelling the star formation process so as to obtain a variety of substructure distributed within our modelled star-forming regions. We show that, by measuring the virial ratio of the stars alone (disregarding the gas completely), we can estimate how much mass a star cluster will retain after gas expulsion to within 10 per cent accuracy, no matter how complex the background structure of the gas is, and we present a simple analytical recipe describing this behaviour. We show that the evolution of the star cluster while still embedded in the natal gas, and the behaviour of the gas before being expelled, is crucial process that affect the time-scale on which the cluster can evolve into a virialized spherical system. Embedded star clusters that have high levels of substructure are subvirial for longer times, enabling them to survive gas expulsion better than a virialized and spherical system. By using a more realistic treatment for the background gas than our previous studies, we find it very difficult to destroy the young clusters with instantaneous gas expulsion. We conclude that gas removal may not be the main culprit for the dissolution of young star clusters.

Graph embedding with rich information through heterogeneous graph

KAUST Repository

Sun, Guolei

2017-11-12

Graph embedding, aiming to learn low-dimensional representations for nodes in graphs, has attracted increasing attention due to its critical application including node classification, link prediction and clustering in social network analysis. Most existing algorithms for graph embedding only rely on the topology information and fail to use the copious information in nodes as well as edges. As a result, their performance for many tasks may not be satisfactory. In this thesis, we proposed a novel and general framework for graph embedding with rich text information (GERI) through constructing a heterogeneous network, in which we integrate node and edge content information with graph topology. Specially, we designed a novel biased random walk to explore the constructed heterogeneous network with the notion of flexible neighborhood. Our sampling strategy can compromise between BFS and DFS local search on heterogeneous graph. To further improve our algorithm, we proposed semi-supervised GERI (SGERI), which learns graph embedding in an discriminative manner through heterogeneous network with label information. The efficacy of our method is demonstrated by extensive comparison experiments with 9 baselines over multi-label and multi-class classification on various datasets including Citeseer, Cora, DBLP and Wiki. It shows that GERI improves the Micro-F1 and Macro-F1 of node classification up to 10%, and SGERI improves GERI by 5% in Wiki.

Software test attacks to break mobile and embedded devices

CERN Document Server

Hagar, Jon Duncan

2013-01-01

Address Errors before Users Find Them Using a mix-and-match approach, Software Test Attacks to Break Mobile and Embedded Devices presents an attack basis for testing mobile and embedded systems. Designed for testers working in the ever-expanding world of ""smart"" devices driven by software, the book focuses on attack-based testing that can be used by individuals and teams. The numerous test attacks show you when a software product does not work (i.e., has bugs) and provide you with information about the software product under test. The book guides you step by step starting with the basics. It

Toxicity of nanoparticles embedded in paints compared to pristine nanoparticles, in vitro study.

Science.gov (United States)

Smulders, Stijn; Luyts, Katrien; Brabants, Gert; Golanski, Luana; Martens, Johan; Vanoirbeek, Jeroen; Hoet, Peter H M

2015-01-22

The unique physicochemical properties of nanomaterials has led to an increased use in the paint and coating industry. In this study, the in vitro toxicity of three pristine ENPs (TiO2, Ag and SiO₂), three aged paints containing ENPs (TiO₂, Ag and SiO₂) and control paints without ENPs were compared. In a first experiment, cytotoxicity was assessed using a biculture consisting of human bronchial epithelial (16HBE14o-) cells and human monocytic cells (THP-1) to determine subtoxic concentrations. In a second experiment, a new coculture model of the lung-blood barrier consisting of 16HBE14o- cells, THP-1 and human lung microvascular endothelial cells (HLMVEC) was used to study pulmonary and extrapulmonary toxicity. The results show that the pristine TiO₂ and Ag ENPs have some cytotoxic effects at relative high dose, while pristine SiO₂ ENPs and all aged paints with ENPs and control paints do not. In the complex triculture model of the lung-blood barrier, no considerable changes were observed after exposure to subtoxic concentration of the different pristine ENPs and paint particles. In conclusion, we demonstrated that although pristine ENPs show some toxic effects, no significant toxicological effects were observed when they were embedded in a complex paint matrix. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Embedded vertically aligned cadmium telluride nanorod arrays grown by one-step electrodeposition for enhanced energy conversion efficiency in three-dimensional nanostructured solar cells.

Science.gov (United States)

Wang, Jun; Liu, Shurong; Mu, Yannan; Liu, Li; A, Runa; Yang, Jiandong; Zhu, Guijie; Meng, Xianwei; Fu, Wuyou; Yang, Haibin

2017-11-01

Vertically aligned CdTe nanorods (NRs) arrays are successfully grown by a simple one-step and template-free electrodeposition method, and then embedded in the CdS window layer to form a novel three-dimensional (3D) heterostructure on flexible substrates. The parameters of electrodeposition such as deposition potential and pH of the solution are varied to analyze their important role in the formation of high quality CdTe NRs arrays. The photovoltaic conversion efficiency of the solar cell based on the 3D heterojunction structure is studied in detail. In comparison with the standard planar heterojunction solar cell, the 3D heterojunction solar cell exhibits better photovoltaic performance, which can be attributed to its enhanced optical absorption ability, increased heterojunction area and improved charge carrier transport. The better photoelectric property of the 3D heterojunction solar cell suggests great application potential in thin film solar cells, and the simple electrodeposition process represents a promising technique for large-scale fabrication of other nanostructured solar energy conversion devices. Copyright © 2017 Elsevier Inc. All rights reserved.

Phylogenetic trees and Euclidean embeddings.

Science.gov (United States)

Layer, Mark; Rhodes, John A

2017-01-01

It was recently observed by de Vienne et al. (Syst Biol 60(6):826-832, 2011) that a simple square root transformation of distances between taxa on a phylogenetic tree allowed for an embedding of the taxa into Euclidean space. While the justification for this was based on a diffusion model of continuous character evolution along the tree, here we give a direct and elementary explanation for it that provides substantial additional insight. We use this embedding to reinterpret the differences between the NJ and BIONJ tree building algorithms, providing one illustration of how this embedding reflects tree structures in data.

Modelling and Analyses of Embedded Systems Design

DEFF Research Database (Denmark)

Brekling, Aske Wiid

We present the MoVES languages: a language with which embedded systems can be specified at a stage in the development process where an application is identified and should be mapped to an execution platform (potentially multi- core). We give a formal model for MoVES that captures and gives......-based verification is a promising approach for assisting developers of embedded systems. We provide examples of system verifications that, in size and complexity, point in the direction of industrially-interesting systems....... semantics to the elements of specifications in the MoVES language. We show that even for seem- ingly simple systems, the complexity of verifying real-time constraints can be overwhelming - but we give an upper limit to the size of the search-space that needs examining. Furthermore, the formal model exposes...

Optimizing Aspect-Oriented Mechanisms for Embedded Applications

Science.gov (United States)

Hundt, Christine; Stöhr, Daniel; Glesner, Sabine

As applications for small embedded mobile devices are getting larger and more complex, it becomes inevitable to adopt more advanced software engineering methods from the field of desktop application development. Aspect-oriented programming (AOP) is a promising approach due to its advanced modularization capabilities. However, existing AOP languages tend to add a substantial overhead in both execution time and code size which restricts their practicality for small devices with limited resources. In this paper, we present optimizations for aspect-oriented mechanisms at the level of the virtual machine. Our experiments show that these optimizations yield a considerable performance gain along with a reduction of the code size. Thus, our optimizations establish the base for using advanced aspect-oriented modularization techniques for developing Java applications on small embedded devices.

Parallel embedded systems: where real-time and low-power meet

DEFF Research Database (Denmark)

Karakehayov, Zdravko; Guo, Yu

2008-01-01

This paper introduces a combination of models and proofs for optimal power management via Dynamic Frequency Scaling and Dynamic Voltage Scaling. The approach is suitable for systems on a chip or microcontrollers where processors run in parallel with embedded peripherals. We have developed...... a software tool, called CASTLE, to provide computer assistance in the design process of energy-aware embedded systems. The tool considers single processor and parallel architectures. An example shows an energy reduction of 23% when the tool allocates two microcontrollers for parallel execution....

IDE Support of String-Embedded Languages

Directory of Open Access Journals (Sweden)

S. Grigorev

2014-01-01

Full Text Available Complex information systems are often implemented by using more than one programming language. Sometimes this variety takes a form of one host and one or few string-embedded languages. Textual representation of clauses in a string-embedded language is built at run time by a host program and then analyzed, compiled or interpreted by a dedicated runtime component (database, web browser etc. Most general-purpose programming languages may play the role of the host; one of the most evident examples of the string-embedded language is the dynamic SQL which was specified in ISO SQL standard and is supported by the majority of DBMS. Standard IDE functionality such as code completion or syntax highlighting can really helps the developers who use this technique. There are several tools providing this functionality, but they all process only one concrete string-embedded language and cannot be easily extended for supporting another language. We present a platform which allows to easily create tools for string-embedded language processing.

Embedding, serial sectioning and staining of zebrafish embryos using JB-4 resin.

Science.gov (United States)

Sullivan-Brown, Jessica; Bisher, Margaret E; Burdine, Rebecca D

2011-01-01

Histological techniques are critical for observing tissue and cellular morphology. In this paper, we outline our protocol for embedding, serial sectioning, staining and visualizing zebrafish embryos embedded in JB-4 plastic resin-a glycol methacrylate-based medium that results in excellent preservation of tissue morphology. In addition, we describe our procedures for staining plastic sections with toluidine blue or hematoxylin and eosin, and show how to couple these stains with whole-mount RNA in situ hybridization. We also describe how to maintain and visualize immunofluorescence and EGFP signals in JB-4 resin. The protocol we outline-from embryo preparation, embedding, sectioning and staining to visualization-can be accomplished in 3 d. Overall, we reinforce that plastic embedding can provide higher resolution of cellular details and is a valuable tool for cellular and morphological studies in zebrafish.

Parametric embedding for class visualization.

Science.gov (United States)

Iwata, Tomoharu; Saito, Kazumi; Ueda, Naonori; Stromsten, Sean; Griffiths, Thomas L; Tenenbaum, Joshua B

2007-09-01

We propose a new method, parametric embedding (PE), that embeds objects with the class structure into a low-dimensional visualization space. PE takes as input a set of class conditional probabilities for given data points and tries to preserve the structure in an embedding space by minimizing a sum of Kullback-Leibler divergences, under the assumption that samples are generated by a gaussian mixture with equal covariances in the embedding space. PE has many potential uses depending on the source of the input data, providing insight into the classifier's behavior in supervised, semisupervised, and unsupervised settings. The PE algorithm has a computational advantage over conventional embedding methods based on pairwise object relations since its complexity scales with the product of the number of objects and the number of classes. We demonstrate PE by visualizing supervised categorization of Web pages, semisupervised categorization of digits, and the relations of words and latent topics found by an unsupervised algorithm, latent Dirichlet allocation.

Cross functional organisational embedded system development

OpenAIRE

Lennon, Sophie

2015-01-01

peer-reviewed Embedded system development is continuing to grow. Medical, automotive and Internet of Things are just some of the market segments. There is a tight coupling between hardware and software when developing an embedded system, often needing to meet strict performance targets, standards requirements and aggressive schedules. Embedded software developers need to consider hardware requirements in far greater detail as they can have a significant impact on the quality and value of t...

Cepstral domain modification of audio signals for data embedding: preliminary results

Science.gov (United States)

Gopalan, Kaliappan

2004-06-01

A method of embedding data in an audio signal using cepstral domain modification is described. Based on successful embedding in the spectral points of perceptually masked regions in each frame of speech, first the technique was extended to embedding in the log spectral domain. This extension resulted at approximately 62 bits /s of embedding with less than 2 percent of bit error rate (BER) for a clean cover speech (from the TIMIT database), and about 2.5 percent for a noisy speech (from an air traffic controller database), when all frames - including silence and transition between voiced and unvoiced segments - were used. Bit error rate increased significantly when the log spectrum in the vicinity of a formant was modified. In the next procedure, embedding by altering the mean cepstral values of two ranges of indices was studied. Tests on both a noisy utterance and a clean utterance indicated barely noticeable perceptual change in speech quality when lower range of cepstral indices - corresponding to vocal tract region - was modified in accordance with data. With an embedding capacity of approximately 62 bits/s - using one bit per each frame regardless of frame energy or type of speech - initial results showed a BER of less than 1.5 percent for a payload capacity of 208 embedded bits using the clean cover speech. BER of less than 1.3 percent resulted for the noisy host with a capacity was 316 bits. When the cepstrum was modified in the region of excitation, BER increased to over 10 percent. With quantization causing no significant problem, the technique warrants further studies with different cepstral ranges and sizes. Pitch-synchronous cepstrum modification, for example, may be more robust to attacks. In addition, cepstrum modification in regions of speech that are perceptually masked - analogous to embedding in frequency masked regions - may yield imperceptible stego audio with low BER.

Adaptive GDDA-BLAST: fast and efficient algorithm for protein sequence embedding.

Directory of Open Access Journals (Sweden)

Yoojin Hong

2010-10-01

Full Text Available A major computational challenge in the genomic era is annotating structure/function to the vast quantities of sequence information that is now available. This problem is illustrated by the fact that most proteins lack comprehensive annotations, even when experimental evidence exists. We previously theorized that embedded-alignment profiles (simply "alignment profiles" hereafter provide a quantitative method that is capable of relating the structural and functional properties of proteins, as well as their evolutionary relationships. A key feature of alignment profiles lies in the interoperability of data format (e.g., alignment information, physio-chemical information, genomic information, etc.. Indeed, we have demonstrated that the Position Specific Scoring Matrices (PSSMs are an informative M-dimension that is scored by quantitatively measuring the embedded or unmodified sequence alignments. Moreover, the information obtained from these alignments is informative, and remains so even in the "twilight zone" of sequence similarity (<25% identity. Although our previous embedding strategy was powerful, it suffered from contaminating alignments (embedded AND unmodified and high computational costs. Herein, we describe the logic and algorithmic process for a heuristic embedding strategy named "Adaptive GDDA-BLAST." Adaptive GDDA-BLAST is, on average, up to 19 times faster than, but has similar sensitivity to our previous method. Further, data are provided to demonstrate the benefits of embedded-alignment measurements in terms of detecting structural homology in highly divergent protein sequences and isolating secondary structural elements of transmembrane and ankyrin-repeat domains. Together, these advances allow further exploration of the embedded alignment data space within sufficiently large data sets to eventually induce relevant statistical inferences. We show that sequence embedding could serve as one of the vehicles for measurement of low

Laser assisted embedding of nanoparticles into metallic materials

International Nuclear Information System (INIS)

Lin Dong; Suslov, Sergey; Ye Chang; Liao Yiliang; Liu, C. Richard; Cheng, Gary J.

2012-01-01

This paper reports a methodology of half-embedding nanoparticles into metallic materials. Transparent and opaque nanoparticles are chosen to demonstrate the process of laser assisted nanoparticle embedding. Dip coating method is used to coat transparent or opaque nanoparticle on the surface of metallic material. Nanoparticles are embedded into substrate by laser irradiation. In this study, the mechanism and process of nanoparticle embedding are investigated. It is found both transparent and opaque nanoparticles embedding are with high densities and good uniformities.

Spatial network surrogates for disentangling complex system structure from spatial embedding of nodes

Science.gov (United States)

Wiedermann, Marc; Donges, Jonathan F.; Kurths, Jürgen; Donner, Reik V.

2016-04-01

Networks with nodes embedded in a metric space have gained increasing interest in recent years. The effects of spatial embedding on the networks' structural characteristics, however, are rarely taken into account when studying their macroscopic properties. Here, we propose a hierarchy of null models to generate random surrogates from a given spatially embedded network that can preserve certain global and local statistics associated with the nodes' embedding in a metric space. Comparing the original network's and the resulting surrogates' global characteristics allows one to quantify to what extent these characteristics are already predetermined by the spatial embedding of the nodes and links. We apply our framework to various real-world spatial networks and show that the proposed models capture macroscopic properties of the networks under study much better than standard random network models that do not account for the nodes' spatial embedding. Depending on the actual performance of the proposed null models, the networks are categorized into different classes. Since many real-world complex networks are in fact spatial networks, the proposed approach is relevant for disentangling the underlying complex system structure from spatial embedding of nodes in many fields, ranging from social systems over infrastructure and neurophysiology to climatology.

Endometrial Cancer Side-Population Cells Show Prominent Migration and Have a Potential to Differentiate into the Mesenchymal Cell Lineage

Science.gov (United States)

Kato, Kiyoko; Takao, Tomoka; Kuboyama, Ayumi; Tanaka, Yoshihiro; Ohgami, Tatsuhiro; Yamaguchi, Shinichiro; Adachi, Sawako; Yoneda, Tomoko; Ueoka, Yousuke; Kato, Keiji; Hayashi, Shinichi; Asanoma, Kazuo; Wake, Norio

2010-01-01

Cancer stem-like cell subpopulations, referred to as “side-population” (SP) cells, have been identified in several tumors based on their ability to efflux the fluorescent dye Hoechst 33342. Although SP cells have been identified in the normal human endometrium and endometrial cancer, little is known about their characteristics. In this study, we isolated and characterized the SP cells in human endometrial cancer cells and in rat endometrial cells expressing oncogenic human K-Ras protein. These SP cells showed i) reduction in the expression levels of differentiation markers; ii) long-term proliferative capacity of the cell cultures; iii) self-renewal capacity in vitro; iv) enhancement of migration, lamellipodia, and, uropodia formation; and v) enhanced tumorigenicity. In nude mice, SP cells formed large, invasive tumors, which were composed of both tumor cells and stromal-like cells with enriched extracellular matrix. The expression levels of vimentin, α-smooth muscle actin, and collagen III were enhanced in SP tumors compared with the levels in non-SP tumors. In addition, analysis of microdissected samples and fluorescence in situ hybridization of Hec1-SP-tumors showed that the stromal-like cells with enriched extracellular matrix contained human DNA, confirming that the stromal-like cells were derived from the inoculated cells. Moreober, in a Matrigel assay, SP cells differentiated into α-smooth muscle actin-expressing cells. These findings demonstrate that SP cells have cancer stem-like cell features, including the potential to differentiate into the mesenchymal cell lineage. PMID:20008133

Canonical Wnts, specifically Wnt-10b, show ability to maintain dermal papilla cells

Energy Technology Data Exchange (ETDEWEB)

Ouji, Yukiteru, E-mail: oujix@naramed-u.ac.jp; Nakamura-Uchiyama, Fukumi; Yoshikawa, Masahide, E-mail: myoshika@naramed-u.ac.jp

2013-08-30

Highlights: •First report on effects of various Wnts on DP cells. •Wnt-10b promoted trichogenesis, while Wnt-3a showed to a limited extent. •Canonical Wnts, specifically Wnt-10b, is important for DP cells maintenance. -- Abstract: Although Wnts are expressed in hair follicles (HFs) and considered to be crucial for maintaining dermal papilla (DP) cells, the functional differences among them remain largely unknown. In the present study, we investigated the effects of Wnts (Wnt-3a, 5a, 10b, 11) on the proliferation of mouse-derived primary DP cells in vitro as well as their trichogenesis-promoting ability using an in vivo skin reconstitution protocol. Wnt-10b promoted cell proliferation and trichogenesis, while Wnt-3a showed those abilities to a limited extent, and Wnt-5a and 11 had no effects. Furthermore, we investigated the effects of these Wnts on cultured DP cells obtained from versican-GFP transgenic mice and found that Wnt-10b had a potent ability to sustain their GFP-positivity. These results suggest that canonical Wnts, specifically Wnt-10b, play important roles in the maintenance of DP cells and trichogenesis.

Messaging Performance of FIPA Interaction Protocols in Networked Embedded Controllers

Directory of Open Access Journals (Sweden)

García JoséAPérez

2008-01-01

Full Text Available Abstract Agent-based technologies in production control systems could facilitate seamless reconfiguration and integration of mechatronic devices/modules into systems. Advances in embedded controllers which are continuously improving computational capabilities allow for software modularization and distribution of decisions. Agent platforms running on embedded controllers could hide the complexity of bootstrap and communication. Therefore, it is important to investigate the messaging performance of the agents whose main motivation is the resource allocation in manufacturing systems (i.e., conveyor system. The tests were implemented using the FIPA-compliant JADE-LEAP agent platform. Agent containers were distributed through networked embedded controllers, and agents were communicating using request and contract-net FIPA interaction protocols. The test scenarios are organized in intercontainer and intracontainer communications. The work shows the messaging performance for the different test scenarios using both interaction protocols.

Messaging Performance of FIPA Interaction Protocols in Networked Embedded Controllers

Directory of Open Access Journals (Sweden)

Omar Jehovani López Orozco

2007-12-01

Full Text Available Agent-based technologies in production control systems could facilitate seamless reconfiguration and integration of mechatronic devices/modules into systems. Advances in embedded controllers which are continuously improving computational capabilities allow for software modularization and distribution of decisions. Agent platforms running on embedded controllers could hide the complexity of bootstrap and communication. Therefore, it is important to investigate the messaging performance of the agents whose main motivation is the resource allocation in manufacturing systems (i.e., conveyor system. The tests were implemented using the FIPA-compliant JADE-LEAP agent platform. Agent containers were distributed through networked embedded controllers, and agents were communicating using request and contract-net FIPA interaction protocols. The test scenarios are organized in intercontainer and intracontainer communications. The work shows the messaging performance for the different test scenarios using both interaction protocols.

Protein extraction from methanol fixed paraffin embedded tissue blocks: A new possibility using cell blocks

Science.gov (United States)

Kokkat, Theresa J.; McGarvey, Diane; Patel, Miral S.; Tieniber, Andrew D.; LiVolsi, Virginia A.; Baloch, Zubair W.

2013-01-01

Background: Methanol fixed and paraffin embedded (MFPE) cellblocks are an essential cytology preparation. However, MFPE cellblocks often contain limited material and their relatively small size has caused them to be overlooked in biomarker discovery. Advances in the field of molecular biotechnology have made it possible to extract proteins from formalin fixed and paraffin embedded (FFPE) tissue blocks. In contrast, there are no established methods for extracting proteins from MFPE cellblocks. We investigated commonly available CHAPS (3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate) buffer, as well as two commercially available Qiagen® kits and compared their effectiveness on MFPE tissue for protein yields. Materials and Methods: MFPE blocks were made by Cellient™ automated system using human tissue specimens from normal and malignant specimens collected in ThinPrep™ Vials. Protein was extracted from Cellient-methanol fixed and paraffin embedded blocks with CHAPS buffer method as well as FFPE and Mammalian Qiagen® kits. Results: Comparison of protein yields demonstrated the effectiveness of various protein extraction methods on MFPE cellblocks. Conclusion: In the current era of minimally invasive techniques to obtain minimal amount of tissue for diagnostic and prognostic purposes, the use of commercial and lab made buffer on low weight MFPE scrapings obtained by Cellient® processor opens new possibilities for protein biomarker research. PMID:24403950

Projective embeddings of homogeneous spaces with small boundary

International Nuclear Information System (INIS)

Arzhantsev, Ivan V

2009-01-01

We study open equivariant projective embeddings of homogeneous spaces such that the complement of the open orbit has codimension at least 2. We establish a criterion for the existence of such an embedding, prove that the set of isomorphism classes of such embeddings is finite, and give a construction of the embeddings in terms of Geometric Invariant Theory. A generalization of Cox's construction and the theory of bunched rings enable us to describe in combinatorial terms the basic geometric properties of embeddings with small boundary

PtRu nanoparticles embedded in nitrogen doped carbon with highly stable CO tolerance and durability

Science.gov (United States)

Ling, Ying; Yang, Zehui; Yang, Jun; Zhang, Yunfeng; Zhang, Quan; Yu, Xinxin; Cai, Weiwei

2018-02-01

As is well known, the lower durability and sluggish methanol oxidation reaction (MOR) of PtRu alloy electrocatalyst blocks the commercialization of direct methanol fuel cells (DMFCs). Here, we design a new PtRu electrocatalyst, with highly stable CO tolerance and durability, in which the PtRu nanoparticles are embedded in nitrogen doped carbon layers derived from carbonization of poly(vinyl pyrrolidone). The newly fabricated electrocatalyst exhibits no loss in electrochemical surface area (ECSA) and MOR activity after potential cycling from 0.6-1.0 V versus reversible hydrogen electrode, while commercial CB/PtRu retains only 50% of its initial ECSA. Meanwhile, due to the same protective layers, the Ru dissolution is decelerated, resulting in stable CO tolerance. Methanol oxidation reaction (MOR) testing indicates that the activity of newly fabricated electrocatalyst is two times higher than that of commercial CB/PtRu, and the fuel cell performance of the embedded PtRu electrocatalyst was comparable to that of commercial CB/PtRu. The embedded PtRu electrocatalyst is applicable in real DMFC operation. This study offers important and useful information for the design and fabrication of durable and CO tolerant electrocatalysts.

Embedded pitch adapters: A high-yield interconnection solution for strip sensors

Energy Technology Data Exchange (ETDEWEB)

Ullán, M., E-mail: miguel.ullan@imb-cnm.csic.es [Centro Nacional de Microelectronica (IMB-CNM, CSIC), Campus UAB-Bellaterra, 08193 Barcelona (Spain); Allport, P.P.; Baca, M.; Broughton, J.; Chisholm, A.; Nikolopoulos, K.; Pyatt, S.; Thomas, J.P.; Wilson, J.A. [School of Physics and Astronomy, University of Birmingham, Birmingham B15 2TT (United Kingdom); Kierstead, J.; Kuczewski, P.; Lynn, D. [Brookhaven National Laboratory, Physics Department and Instrumentation Division, Upton, NY 11973-5000 (United States); Hommels, L.B.A. [Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Fleta, C.; Fernandez-Tejero, J.; Quirion, D. [Centro Nacional de Microelectronica (IMB-CNM, CSIC), Campus UAB-Bellaterra, 08193 Barcelona (Spain); Bloch, I.; Díez, S.; Gregor, I.M.; Lohwasser, K. [DESY, Notkestrasse 85, 22607 Hamburg (Germany); and others

2016-09-21

A proposal to fabricate large area strip sensors with integrated, or embedded, pitch adapters is presented for the End-cap part of the Inner Tracker in the ATLAS experiment. To implement the embedded pitch adapters, a second metal layer is used in the sensor fabrication, for signal routing to the ASICs. Sensors with different embedded pitch adapters have been fabricated in order to optimize the design and technology. Inter-strip capacitance, noise, pick-up, cross-talk, signal efficiency, and fabrication yield have been taken into account in their design and fabrication. Inter-strip capacitance tests taking into account all channel neighbors reveal the important differences between the various designs considered. These tests have been correlated with noise figures obtained in full assembled modules, showing that the tests performed on the bare sensors are a valid tool to estimate the final noise in the full module. The full modules have been subjected to test beam experiments in order to evaluate the incidence of cross-talk, pick-up, and signal loss. The detailed analysis shows no indication of cross-talk or pick-up as no additional hits can be observed in any channel not being hit by the beam above 170 mV threshold, and the signal in those channels is always below 1% of the signal recorded in the channel being hit, above 100 mV threshold. First results on irradiated mini-sensors with embedded pitch adapters do not show any change in the interstrip capacitance measurements with only the first neighbors connected.

Time-Scale Invariant Audio Data Embedding

Directory of Open Access Journals (Sweden)

Mansour Mohamed F

2003-01-01

Full Text Available We propose a novel algorithm for high-quality data embedding in audio. The algorithm is based on changing the relative length of the middle segment between two successive maximum and minimum peaks to embed data. Spline interpolation is used to change the lengths. To ensure smooth monotonic behavior between peaks, a hybrid orthogonal and nonorthogonal wavelet decomposition is used prior to data embedding. The possible data embedding rates are between 20 and 30 bps. However, for practical purposes, we use repetition codes, and the effective embedding data rate is around 5 bps. The algorithm is invariant after time-scale modification, time shift, and time cropping. It gives high-quality output and is robust to mp3 compression.

The Activation of Embedded Words in Spoken Word Recognition.

Science.gov (United States)

Zhang, Xujin; Samuel, Arthur G

2015-01-01

The current study investigated how listeners understand English words that have shorter words embedded in them. A series of auditory-auditory priming experiments assessed the activation of six types of embedded words (2 embedded positions × 3 embedded proportions) under different listening conditions. Facilitation of lexical decision responses to targets (e.g., pig) associated with words embedded in primes (e.g., hamster ) indexed activation of the embedded words (e.g., ham ). When the listening conditions were optimal, isolated embedded words (e.g., ham ) primed their targets in all six conditions (Experiment 1a). Within carrier words (e.g., hamster ), the same set of embedded words produced priming only when they were at the beginning or comprised a large proportion of the carrier word (Experiment 1b). When the listening conditions were made suboptimal by expanding or compressing the primes, significant priming was found for isolated embedded words (Experiment 2a), but no priming was produced when the carrier words were compressed/expanded (Experiment 2b). Similarly, priming was eliminated when the carrier words were presented with one segment replaced by noise (Experiment 3). When cognitive load was imposed, priming for embedded words was again found when they were presented in isolation (Experiment 4a), but not when they were embedded in the carrier words (Experiment 4b). The results suggest that both embedded position and proportion play important roles in the activation of embedded words, but that such activation only occurs under unusually good listening conditions.

[Use of archival formalin-fixed, paraffin-embedded (FFPE) tissue samples for molecular genetic analysis in diffuse large B-cell lymphoma (DLBCL)].

Science.gov (United States)

Jarošová, Marie; Kučerová, Jana; Flodr, Patrik; Mikešová, Michaela; Procházka, Vít; Papajík, Tomáš

2014-04-01

The currently valid molecular genetic subclassification of patients with diffuse large B-cell lymphoma (DLBCL) into three prognostic subgroups based on expression profiling has been the objective of numerous genetic studies. In routine clinical practice, however, expression profiling technology remains unavailable for the most of centers. Apart from the technology, in some cases molecular genetic laboratories have problems obtaining high-quality material, i.e. fresh tissues, for RNA isolation to determine gene expression. One possibility is to determine the gene expression from RNA obtained by isolation from formalin-fixed, paraffin-embedded (FFPE) tissue. This pilot study aimed at isolating RNA from FFPE in patients diagnosed with DLBCL and verifying the potential use of such RNA for the expression analysis of 7 selected genes. Although the study showed that it is possible to isolate RNA and determine the expression of the selected genes from archival material, the values of relative expression of some genes in the set were too variable to be used for unambiguous prognostic classification. It was confirmed that retrospective analyses of selected genes may be performed with sufficient material obtained, and that properly archived blocks may be used for molecular biology analyses even after 8 years.

Embedding Complementarity in HCI Methods and Techniques

DEFF Research Database (Denmark)

Nielsen, Janni; Yssing, Carsten; Tweddell Levinsen, Karin

Differences in cultural contexts constitute differences in cognition, and research has shown that different cultures may use different cognitive tools for perception and reasoning. The cultural embeddings are significant in relation to HCI, because the cultural context is also embedded in the tec......Differences in cultural contexts constitute differences in cognition, and research has shown that different cultures may use different cognitive tools for perception and reasoning. The cultural embeddings are significant in relation to HCI, because the cultural context is also embedded...... the HCI paradigm in system development....

Graphical Model Debugger Framework for Embedded Systems

DEFF Research Database (Denmark)

Zeng, Kebin

2010-01-01

Model Driven Software Development has offered a faster way to design and implement embedded real-time software by moving the design to a model level, and by transforming models to code. However, the testing of embedded systems has remained at the code level. This paper presents a Graphical Model...... Debugger Framework, providing an auxiliary avenue of analysis of system models at runtime by executing generated code and updating models synchronously, which allows embedded developers to focus on the model level. With the model debugger, embedded developers can graphically test their design model...

First-principles study of H, O, and N adsorption on metal embedded carbon nanotubes

Energy Technology Data Exchange (ETDEWEB)

Li, Detian [Science and Technology on Vacuum Technology and Physics Laboratory, Lanzhou Institute of Physics, Lanzhou, Gansu 730000 (China); Institute of Micro-nano Structures & Optoelectronics, Wenzhou University, Wenzhou, Zhejiang 325035 (China); Luo, Haijun, E-mail: luohaijun@wzu.edu.cn [Institute of Micro-nano Structures & Optoelectronics, Wenzhou University, Wenzhou, Zhejiang 325035 (China); Cai, Jianqiu [Institute of Micro-nano Structures & Optoelectronics, Wenzhou University, Wenzhou, Zhejiang 325035 (China); Cheng, Yongjun [Science and Technology on Vacuum Technology and Physics Laboratory, Lanzhou Institute of Physics, Lanzhou, Gansu 730000 (China); Shao, Xiji [Institute of Micro-nano Structures & Optoelectronics, Wenzhou University, Wenzhou, Zhejiang 325035 (China); Dong, Changkun, E-mail: dck@wzu.edu.cn [Science and Technology on Vacuum Technology and Physics Laboratory, Lanzhou Institute of Physics, Lanzhou, Gansu 730000 (China); Institute of Micro-nano Structures & Optoelectronics, Wenzhou University, Wenzhou, Zhejiang 325035 (China)

2017-05-01

Highlights: • Ni or Fe embedment and high atomic adsorption coverage benefit applications like hydrogen storage and field emission. • Ni or Fe embedment could help tune the catalytic properties. • Ni or Fe embedment enhances the adatom-SWNT interaction significantly. - Abstract: The density functional theory calculation has been conducted to investigate the structural and electronic properties, including the adsorption energies, bond structures, work functions, charge transfer behaviors, and density of states for pristine, Ni-, and Fe-embedded capped (5, 5) single-walled carbon nanotubes (SWNTs) with different coverage of atomic hydrogen, oxygen, and nitrogen adsorptions. Ni or Fe embedment enhances the adatom-SWNT interactions significantly for three kinds of gas atoms with the increases of the adsorption energies. The SWNT work function drops with H adsorption, while Ni or Fe embedment assists further the reduction. When increasing the coverage, the adsorption energy decreases and the work function climbs for O adsorption, but the nitrogen adsorption energy increases. The Bader charge transfer analysis implies that the cap possesses higher oxygen reduction activities than the tube, and the density of states analysis shows that Ni or Fe embedment deepens the C-adatom hybridizations.

Minimum curvilinearity to enhance topological prediction of protein interactions by network embedding

KAUST Repository

Cannistraci, Carlo

2013-06-21

Motivation: Most functions within the cell emerge thanks to protein-protein interactions (PPIs), yet experimental determination of PPIs is both expensive and time-consuming. PPI networks present significant levels of noise and incompleteness. Predicting interactions using only PPI-network topology (topological prediction) is difficult but essential when prior biological knowledge is absent or unreliable.Methods: Network embedding emphasizes the relations between network proteins embedded in a low-dimensional space, in which protein pairs that are closer to each other represent good candidate interactions. To achieve network denoising, which boosts prediction performance, we first applied minimum curvilinear embedding (MCE), and then adopted shortest path (SP) in the reduced space to assign likelihood scores to candidate interactions. Furthermore, we introduce (i) a new valid variation of MCE, named non-centred MCE (ncMCE); (ii) two automatic strategies for selecting the appropriate embedding dimension; and (iii) two new randomized procedures for evaluating predictions.Results: We compared our method against several unsupervised and supervisedly tuned embedding approaches and node neighbourhood techniques. Despite its computational simplicity, ncMCE-SP was the overall leader, outperforming the current methods in topological link prediction.Conclusion: Minimum curvilinearity is a valuable non-linear framework that we successfully applied to the embedding of protein networks for the unsupervised prediction of novel PPIs. The rationale for our approach is that biological and evolutionary information is imprinted in the non-linear patterns hidden behind the protein network topology, and can be exploited for predicting new protein links. The predicted PPIs represent good candidates for testing in high-throughput experiments or for exploitation in systems biology tools such as those used for network-based inference and prediction of disease-related functional modules. The

Very wide register : an asymmetric register file organization for low power embedded processors.

NARCIS (Netherlands)

Raghavan, P.; Lambrechts, A.; Jayapala, M.; Catthoor, F.; Verkest, D.T.M.L.; Corporaal, H.

2007-01-01

In current embedded systems processors, multi-ported register files are one of the most power hungry parts of the processor, even when they are clustered. This paper presents a novel register file architecture, which has single ported cells and asymmetric interfaces to the memory and to the

Smart multicore embedded systems

CERN Document Server

Bertels, Koen; Karlsson, Sven; Pacull, François

2014-01-01

This book provides a single-source reference to the state-of-the-art of high-level programming models and compilation tool-chains for embedded system platforms. The authors address challenges faced by programmers developing software to implement parallel applications in embedded systems, where very often they are forced to rewrite sequential programs into parallel software, taking into account all the low level features and peculiarities of the underlying platforms. Readers will benefit from these authors’ approach, which takes into account both the application requirements and the platform specificities of various embedded systems from different industries. Parallel programming tool-chains are described that take as input parameters both the application and the platform model, then determine relevant transformations and mapping decisions on the concrete platform, minimizing user intervention and hiding the difficulties related to the correct and efficient use of memory hierarchy and low level code generati...

PERANCANGAN KANAL KOMUNIKASI PADA TRANSACTION LEVEL MODELING DALAM PERANCANGAN EMBEDDED SYSTEM

Directory of Open Access Journals (Sweden)

Maman Abdurohman

2012-05-01

Full Text Available Pada embedded system terdapat dua bagian penting yaitu komponen komputasi (register dan komponen komunikasi. Komponen komunikasi menjadi perhatian penting pada mekanisme pemodelan level transaksi (Transaction Level Modeling, TLM. Kanal komunikasi adalah komponen untuk transaksi antar register. Fokus pembahasan TLM adalah perancangan kanal yang dapat mengakomodasi untuk peningkatan level transaksi. Kanal (channel adalah implementasi bus untuk komunikasi antar komponen pada embedded system. Hal ini adalah kunci penting untuk mencapai impelementasi TLM untuk meningkatkan efisiensi pemodelan. Pada paper ini diusulkan beberapa definisi rancangan kanal sebagai implementasi TLM untuk perancangan embedded system. Hasilnya menunjukan bahwa rancangan kanal dapat berjalan sebagai bus untuk transaksi pada TLM. Paper ini menggunakan SystemC sebagai bahasa pemodelan. On embedded systems, there are two important parts: computational components (registers and communication components. Communication component becomes an important attention on the mechanism of transaction level modeling (TLM. Communication channel is a component for transactions between registers. The focus of TLM is the design of the channel that could accommodate for the increased level of transactions. Channel is the implementation of the bus for communication between components in embedded systems. This is an important key to achieve the implementation of TLM to improve the efficiency of modeling. This paper proposed a definition of the channel design as the implementation of TLM for embedded systems design. The result shows that the design of the channel can run as a bus for transactions on the TLM. This paper uses SystemC as modeling language.

Wavelet-based audio embedding and audio/video compression

Science.gov (United States)

Mendenhall, Michael J.; Claypoole, Roger L., Jr.

2001-12-01

Watermarking, traditionally used for copyright protection, is used in a new and exciting way. An efficient wavelet-based watermarking technique embeds audio information into a video signal. Several effective compression techniques are applied to compress the resulting audio/video signal in an embedded fashion. This wavelet-based compression algorithm incorporates bit-plane coding, index coding, and Huffman coding. To demonstrate the potential of this audio embedding and audio/video compression algorithm, we embed an audio signal into a video signal and then compress. Results show that overall compression rates of 15:1 can be achieved. The video signal is reconstructed with a median PSNR of nearly 33 dB. Finally, the audio signal is extracted from the compressed audio/video signal without error.

Energy Efficiency of Task Allocation for Embedded JPEG Systems

Directory of Open Access Journals (Sweden)

Yang-Hsin Fan

2014-01-01

Full Text Available Embedded system works everywhere for repeatedly performing a few particular functionalities. Well-known products include consumer electronics, smart home applications, and telematics device, and so forth. Recently, developing methodology of embedded systems is applied to conduct the design of cloud embedded system resulting in the applications of embedded system being more diverse. However, the more energy consumes result from the more embedded system works. This study presents hyperrectangle technology (HT to embedded system for obtaining energy saving. The HT adopts drift effect to construct embedded systems with more hardware circuits than software components or vice versa. It can fast construct embedded system with a set of hardware circuits and software components. Moreover, it has a great benefit to fast explore energy consumption for various embedded systems. The effects are presented by assessing a JPEG benchmarks. Experimental results demonstrate that the HT, respectively, achieves the energy saving by 29.84%, 2.07%, and 68.80% on average to GA, GHO, and Lin.

Energy efficiency of task allocation for embedded JPEG systems.

Science.gov (United States)

Fan, Yang-Hsin; Wu, Jan-Ou; Wang, San-Fu

2014-01-01

Embedded system works everywhere for repeatedly performing a few particular functionalities. Well-known products include consumer electronics, smart home applications, and telematics device, and so forth. Recently, developing methodology of embedded systems is applied to conduct the design of cloud embedded system resulting in the applications of embedded system being more diverse. However, the more energy consumes result from the more embedded system works. This study presents hyperrectangle technology (HT) to embedded system for obtaining energy saving. The HT adopts drift effect to construct embedded systems with more hardware circuits than software components or vice versa. It can fast construct embedded system with a set of hardware circuits and software components. Moreover, it has a great benefit to fast explore energy consumption for various embedded systems. The effects are presented by assessing a JPEG benchmarks. Experimental results demonstrate that the HT, respectively, achieves the energy saving by 29.84%, 2.07%, and 68.80% on average to GA, GHO, and Lin.

Single step deposition of an interacting layer of a perovskite matrix with embedded quantum dots

Science.gov (United States)

Ngo, Thi Tuyen; Suarez, Isaac; Sanchez, Rafael S.; Martinez-Pastor, Juan P.; Mora-Sero, Ivan

2016-07-01

Hybrid lead halide perovskite (PS) derivatives have emerged as very promising materials for the development of optoelectronic devices in the last few years. At the same time, inorganic nanocrystals with quantum confinement (QDs) possess unique properties that make them suitable materials for the development of photovoltaics, imaging and lighting applications, among others. In this work, we report on a new methodology for the deposition of high quality, large grain size and pinhole free PS films (CH3NH3PbI3) with embedded PbS and PbS/CdS core/shell Quantum Dots (QDs). The strong interaction between both semiconductors is revealed by the formation of an exciplex state, which is monitored by photoluminescence and electroluminescence experiments. The radiative exciplex relaxation is centered in the near infrared region (NIR), ~1200 nm, which corresponds to lower energies than the corresponding band gap of both perovskite (PS) and QDs. Our approach allows the fabrication of multi-wavelength light emitting diodes (LEDs) based on a PS matrix with embedded QDs, which show considerably low turn-on potentials. The presence of the exciplex state of PS and QDs opens up a broad range of possibilities with important implications in both LEDs and solar cells.Hybrid lead halide perovskite (PS) derivatives have emerged as very promising materials for the development of optoelectronic devices in the last few years. At the same time, inorganic nanocrystals with quantum confinement (QDs) possess unique properties that make them suitable materials for the development of photovoltaics, imaging and lighting applications, among others. In this work, we report on a new methodology for the deposition of high quality, large grain size and pinhole free PS films (CH3NH3PbI3) with embedded PbS and PbS/CdS core/shell Quantum Dots (QDs). The strong interaction between both semiconductors is revealed by the formation of an exciplex state, which is monitored by photoluminescence and

Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instability

OpenAIRE

Fukawatase, Yoshihiro; Toyoda, Masashi; Okamura, Kohji; Nakamura, Ken-ichi; Nakabayashi, Kazuhiko; Takada, Shuji; Yamazaki-Inoue, Mayu; Masuda, Akira; Nasu, Michiyo; Hata, Kenichiro; Hanaoka, Kazunori; Higuchi, Akon; Takubo, Kaiyo; Umezawa, Akihiro

2014-01-01

Ataxia telangiectasia is a neurodegenerative inherited disease with chromosomal instability and hypersensitivity to ionizing radiation. iPS cells lacking ATM (AT-iPS cells) exhibited hypersensitivity to X-ray irradiation, one of the characteristics of the disease. While parental ataxia telangiectasia cells exhibited significant chromosomal abnormalities, AT-iPS cells did not show any chromosomal instability in vitro for at least 80 passages (560 days). Whole exome analysis also showed a compa...

Abelian embedding formulation of the Stueckelberg model and its power-counting renormalizable extension

International Nuclear Information System (INIS)

Quadri, Andrea

2006-01-01

We elucidate the geometry of the polynomial formulation of the non-Abelian Stueckelberg mechanism. We show that a natural off-shell nilpotent Becchi-Rouet-Stora-Tyutin (BRST) differential exists allowing to implement the constraint on the σ field by means of BRST techniques. This is achieved by extending the ghost sector by an additional U(1) factor (Abelian embedding). An important consequence is that a further BRST-invariant but not gauge-invariant mass term can be written for the non-Abelian gauge fields. As all versions of the Stueckelberg theory, also the Abelian embedding formulation yields a nonpower-counting renormalizable theory in D=4. We then derive its natural power-counting renormalizable extension and show that the physical spectrum contains a physical massive scalar particle. Physical unitarity is also established. This model implements the spontaneous symmetry breaking in the Abelian embedding formalism

The Activation of Embedded Words in Spoken Word Recognition

Science.gov (United States)

Zhang, Xujin; Samuel, Arthur G.

2015-01-01

The current study investigated how listeners understand English words that have shorter words embedded in them. A series of auditory-auditory priming experiments assessed the activation of six types of embedded words (2 embedded positions × 3 embedded proportions) under different listening conditions. Facilitation of lexical decision responses to targets (e.g., pig) associated with words embedded in primes (e.g., hamster) indexed activation of the embedded words (e.g., ham). When the listening conditions were optimal, isolated embedded words (e.g., ham) primed their targets in all six conditions (Experiment 1a). Within carrier words (e.g., hamster), the same set of embedded words produced priming only when they were at the beginning or comprised a large proportion of the carrier word (Experiment 1b). When the listening conditions were made suboptimal by expanding or compressing the primes, significant priming was found for isolated embedded words (Experiment 2a), but no priming was produced when the carrier words were compressed/expanded (Experiment 2b). Similarly, priming was eliminated when the carrier words were presented with one segment replaced by noise (Experiment 3). When cognitive load was imposed, priming for embedded words was again found when they were presented in isolation (Experiment 4a), but not when they were embedded in the carrier words (Experiment 4b). The results suggest that both embedded position and proportion play important roles in the activation of embedded words, but that such activation only occurs under unusually good listening conditions. PMID:25593407

Steganographic embedding in containers-images

Science.gov (United States)

Nikishova, A. V.; Omelchenko, T. A.; Makedonskij, S. A.

2018-05-01

Steganography is one of the approaches to ensuring the protection of information transmitted over the network. But a steganographic method should vary depending on a used container. According to statistics, the most widely used containers are images and the most common image format is JPEG. Authors propose a method of data embedding into a frequency area of images in format JPEG 2000. It is proposed to use the method of Benham-Memon- Yeo-Yeung, in which instead of discrete cosine transform, discrete wavelet transform is used. Two requirements for images are formulated. Structure similarity is chosen to obtain quality assessment of data embedding. Experiments confirm that requirements satisfaction allows achieving high quality assessment of data embedding.

Embedding Versus Immersion in General Relativity

OpenAIRE

Monte, Edmundo M.

2009-01-01

We briefly discuss the concepts of immersion and embedding of space-times in higher-dimensional spaces. We revisit the classical work by Kasner in which he constructs a model of immersion of the Schwarzschild exterior solution into a six-dimensional pseudo-Euclidean manifold. We show that, from a physical point of view, this model is not entirely satisfactory since the causal structure of the immersed space-time is not preserved by the immersion.

Embedding initial data for black hole collisions

OpenAIRE

Romano, Joseph D.; Price, Richard H.

1994-01-01

We discuss isometric embedding diagrams for the visualization of initial data for the problem of the head-on collision of two black holes. The problem of constructing the embedding diagrams is explicitly presented for the best studied initial data, the Misner geometry. We present a partial solution of the embedding diagrams and discuss issues related to completing the solution.

Embedded Creativity: Teaching Design Thinking via Distance Education

Science.gov (United States)

Lloyd, Peter

2013-01-01

This paper shows how the design thinking skills of students learning at a distance can be consciously developed, and deliberately applied outside of the creative industries in what are termed 'embedded' contexts. The distance learning model of education pioneered by The Open University is briefly described before the technological…

Promise of a low power mobile CPU based embedded system in artificial leg control.

Science.gov (United States)

Hernandez, Robert; Zhang, Fan; Zhang, Xiaorong; Huang, He; Yang, Qing

2012-01-01

This paper presents the design and implementation of a low power embedded system using mobile processor technology (Intel Atom™ Z530 Processor) specifically tailored for a neural-machine interface (NMI) for artificial limbs. This embedded system effectively performs our previously developed NMI algorithm based on neuromuscular-mechanical fusion and phase-dependent pattern classification. The analysis shows that NMI embedded system can meet real-time constraints with high accuracies for recognizing the user's locomotion mode. Our implementation utilizes the mobile processor efficiently to allow a power consumption of 2.2 watts and low CPU utilization (less than 4.3%) while executing the complex NMI algorithm. Our experiments have shown that the highly optimized C program implementation on the embedded system has superb advantages over existing PC implementations on MATLAB. The study results suggest that mobile-CPU-based embedded system is promising for implementing advanced control for powered lower limb prostheses.

Embedded Academic Librarianship: A Review of the Literature

Directory of Open Access Journals (Sweden)

Stephanie J. Schulte

2012-12-01

Full Text Available Objectives – The purpose of this review is to examine the development of embedded librarianship, its multiple meanings, and activities in practice. The review will also report on published outcomes and future research needs of embedded librarian programs.Methods – A search of current literature was conducted and summarized searching PubMed, CINAHL, Library, Information Science & Technology Abstracts (EBSCO, Academic Search Complete, and ERIC (EBSCO through August 23, 2012. Articles wereselected for inclusion in the review if they reported research findings related to embedded librarianship, if they provided unique case reports about embedded librarian programs, or if they provided substantive editorial comments on the topic. Relevant study findings were assessed for quality and presented in tabular and narrative form.Results – Currently, there is disparity in how embedded librarianship is being definedand used in common practice, ranging from embedding an online component into asingle course to full physical and cultural integration into an academic college orbusiness unit of an organization. Activities of embedded librarians include creatingcourse integrated instruction modules for either face-to-face or online courses, providingin depth research assistance to students or faculty, and co-locating within colleges orcustomer units via office hours for a few hours to all hours per week. Several case reports exist in the recent literature. Few high quality research studies reporting outcomes of librarians or library programs labeled as embedded exist at this point. Some evidence suggests that embedded librarians are effective with regards to student learning of information literacy objectives. Surveys suggest that both students and faculty appreciate embedded librarian services.Conclusion – Most published accounts discuss librarians embedding content and ready access to services in an online course management system. A few notable cases

Modeling of Embedded Human Systems

Science.gov (United States)

2013-07-01

ISAT study [7] for DARPA in 20051 concretized the notion of an embedded human, who is a necessary component of the system. The proposed work integrates...Technology, IEEE Transactions on, vol. 16, no. 2, pp. 229–244, March 2008. [7] C. J. Tomlin and S. S. Sastry, “Embedded humans,” tech. rep., DARPA ISAT

Light trapping in a-Si/c-Si heterojunction solar cells by embedded ITO nanoparticles at rear surface

Science.gov (United States)

Dhar, Sukanta; Mandal, Sourav; Mitra, Suchismita; Ghosh, Hemanta; Mukherjee, Sampad; Banerjee, Chandan; Saha, Hiranmoy; Barua, A. K.

2017-12-01

The advantages of the amorphous silicon (a-Si)/crystalline silicon (c-Si) hetero junction technology are low temperature (oxide (ITO) nanoparticles embedded in amorphous silicon material at the rear side of the crystalline wafer. The nanoparticles were embedded in silicon to have higher scattering efficiency, as has been established by simulation studies. It has been shown that significant photocurrent enhancements (32.8 mA cm-2 to 35.1 mA cm-2) are achieved because of high scattering and coupling efficiency of the embedded nanoparticles into the silicon device, leading to an increase in efficiency from 13.74% to 15.22%. In addition, we have observed a small increase in open circuit voltage. This may be due to the surface passivation during the ITO nanoparticle formation with hydrogen plasma treatment. We also support our experimental results by simulation, with the help of a commercial finite-difference time-domain (FDTD) software solution.

Real time polarization sensor image processing on an embedded FPGA/multi-core DSP system

Science.gov (United States)

Bednara, Marcus; Chuchacz-Kowalczyk, Katarzyna

2015-05-01

Most embedded image processing SoCs available on the market are highly optimized for typical consumer applications like video encoding/decoding, motion estimation or several image enhancement processes as used in DSLR or digital video cameras. For non-consumer applications, on the other hand, optimized embedded hardware is rarely available, so often PC based image processing systems are used. We show how a real time capable image processing system for a non-consumer application - namely polarization image data processing - can be efficiently implemented on an FPGA and multi-core DSP based embedded hardware platform.

Methodology and Supporting Toolset Advancing Embedded Systems Quality

DEFF Research Database (Denmark)

Berger, Michael Stübert; Soler, José; Brewka, Lukasz Jerzy

2013-01-01

Software quality is of primary importance in the development of embedded systems that are often used in safety-critical applications. Moreover, as the life cycle of embedded products becomes increasingly tighter, productivity and quality are simultaneously required and closely interrelated towards...... delivering competitive products. In this context, the MODUS (Methodology and supporting toolset advancing embedded systems quality) project aims to provide a pragmatic and viable solution that will allow SMEs to substantially improve their positioning in the embedded-systems development market. This paper...... will describe the MODUS project with focus on the technical methodologies that will be developed advancing embedded system quality....

Quantum thetas on noncommutative Td with general embeddings

International Nuclear Information System (INIS)

Chang-Young, Ee; Kim, Hoil

2008-01-01

In this paper, we construct quantum theta functions over noncommutative T d with general embeddings. Manin has constructed quantum theta functions from the lattice embedding into vector space x finite group. We extend Manin's construction of quantum thetas to the case of general embedding of vector space x lattice x torus. It turns out that only for the vector space part of the embedding there exists the holomorphic theta vector, while for the lattice part there does not. Furthermore, the so-called quantum translations from embedding into the lattice part become non-additive, while those from the vector space part are additive

AdS2 models in an embedding superspace

International Nuclear Information System (INIS)

McKeon, D.G.C.; Sherry, T.N.

2003-01-01

An embedding superspace, whose bosonic part is the flat (2+1)-dimensional embedding space for AdS 2 , is introduced. Superfields and several supersymmetric models are examined in the embedded AdS 2 superspace

Novel photodefined polymer-embedded vias for silicon interposers

International Nuclear Information System (INIS)

Thadesar, Paragkumar A; Bakir, Muhannad S

2013-01-01

This paper describes the fabrication and characterization of novel photodefined polymer-embedded vias for silicon interposers. The fabricated polymer-embedded vias can help obtain ∼3.8× reduction in via-to-via capacitance as well as a reduction in insertion loss compared to TSVs with a silicon dioxide liner. Polymer-embedded vias 100 μm in diameter, 270 μm tall and at 250 μm pitch were fabricated. Resistance and leakage measurements were performed for the fabricated polymer-embedded vias. The average value of the measured resistance for 20 polymer-embedded vias is 2.54 mΩ and the maximum measured via-to-via leakage current for 10 pairs of polymer-embedded vias is 80.8 pA for an applied voltage of 200 V. (paper)

Nanofluidic Device with Embedded Nanopore

Science.gov (United States)

Zhang, Yuning; Reisner, Walter

2014-03-01

Nanofluidic based devices are robust methods for biomolecular sensing and single DNA manipulation. Nanopore-based DNA sensing has attractive features that make it a leading candidate as a single-molecule DNA sequencing technology. Nanochannel based extension of DNA, combined with enzymatic or denaturation-based barcoding schemes, is already a powerful approach for genome analysis. We believe that there is revolutionary potential in devices that combine nanochannels with nanpore detectors. In particular, due to the fast translocation of a DNA molecule through a standard nanopore configuration, there is an unfavorable trade-off between signal and sequence resolution. With a combined nanochannel-nanopore device, based on embedding a nanopore inside a nanochannel, we can in principle gain independent control over both DNA translocation speed and sensing signal, solving the key draw-back of the standard nanopore configuration. We demonstrate that we can detect - using fluorescent microscopy - successful translocation of DNA from the nanochannel out through the nanopore, a possible method to 'select' a given barcode for further analysis. We also show that in equilibrium DNA will not escape through an embedded sub-persistence length nanopore until a certain voltage bias is added.

Isometric embeddings in cosmology and astrophysics

Indian Academy of Sciences (India)

embedding theory, a given spacetime (or 'brane') is embedded in a higher- ..... If one recalls that the motivation (at least in part) for non-compact extra ... to successfully embed (apparently perfect fluid) astrophysical models, we typically need to.

Tunable, flexible antireflection layer of ZnO nanowires embedded in PDMS.

Science.gov (United States)

Kim, Min Kyu; Yi, Dong Kee; Paik, Ungyu

2010-05-18

In this article, we report the fabrication of ordered hybrid structures composed of ZnO nanowires and a polymeric matrix with a polymer precursor infiltrating the nanowire arrays. The antireflective properties of the resulting ZnO nanowire-embedded polydimethylsiloxane composite (ZPC) were investigated at various ZnO nanowire lengths and ZPC bending angles. Interestingly, we found that whereas the antireflective properties showed a strong dependence on the length of the embedded ZnO nanowires in PDMS, the bending of ZPC has little effect on the antireflective properties.

Interfacial wave dynamics of a drop with an embedded bubble.

Science.gov (United States)

Bhattacharya, S

2016-02-01

This article describes how an embedded bubble changes the surface wave of a suspended liquid drop, and how such modifications, if recorded experimentally, can be used to detect voids in typically opaque interior of the fluid. The analysis uses a matrix formalism to predict the frequencies for natural oscillation and the deformation for acoustically induced forced vibration. The theory shows that the embedded cavity causes major shifts in the frequency and amplitude values as well as twofold increase in number of natural modes, indicating multifacetted utility of the results in process diagnostics, material characterizations, and combustion technology.

Fracture of vacancy-defected carbon nanotubes and their embedded nanocomposites

International Nuclear Information System (INIS)

Xiao Shaoping; Hou Wenyi

2006-01-01

In this paper, we investigate effects of vacancy defects on fracture of carbon nanotubes and carbon nanotube/aluminum composites. Our studies show that even a one-atom vacancy defect can dramatically reduce the failure stresses and strains of carbon nanotubes. Consequently, nanocomposites, in which vacancy-defected nanotubes are embedded, exhibit different characteristics from those in which pristine nanotubes are embedded. It has been found that defected nanotubes with a small volume fraction cannot reinforce but instead weaken nanocomposite materials. Although a large volume fraction of defected nanotubes can slightly increase the failure stresses of nanocomposites, the failure strains of nanocomposites are always decreased

Sharing Real-Time Objects in Distributed Embedded Systems

DEFF Research Database (Denmark)

Larsen, Erland Ketil; Havn, Ib

2015-01-01

microcontrollers connected by a RS-485 bus. The demo system shows that it is relatively simple to implement a distributed embedded system with the provided API, and the latency of the communication service is predictable. A low coupling to hardware makes it easy to port to another platform and/or another network...

Embedded Solenoid Transformer for Power Conversion

DEFF Research Database (Denmark)

2015-01-01

A resonant power converter for operation in the radio frequency range, preferably in the VHF, comprises at least one PCB-embedded transformer. The transformer is configured for radio frequency operation and comprises a printed circuit board defining a horizontal plane, the printed circuit board...... comprising at least two horizontal conductive layers separated by an isolating layer, a first embedded solenoid forming a primary winding of the transformer and a second embedded solenoid being arranged parallel to the first solenoid and forming a secondary winding of the transformer, wherein the first...

Bootstrap embedding: An internally consistent fragment-based method

Energy Technology Data Exchange (ETDEWEB)

Welborn, Matthew; Tsuchimochi, Takashi; Van Voorhis, Troy [Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139 (United States)

2016-08-21

Strong correlation poses a difficult problem for electronic structure theory, with computational cost scaling quickly with system size. Fragment embedding is an attractive approach to this problem. By dividing a large complicated system into smaller manageable fragments “embedded” in an approximate description of the rest of the system, we can hope to ameliorate the steep cost of correlated calculations. While appealing, these methods often converge slowly with fragment size because of small errors at the boundary between fragment and bath. We describe a new electronic embedding method, dubbed “Bootstrap Embedding,” a self-consistent wavefunction-in-wavefunction embedding theory that uses overlapping fragments to improve the description of fragment edges. We apply this method to the one dimensional Hubbard model and a translationally asymmetric variant, and find that it performs very well for energies and populations. We find Bootstrap Embedding converges rapidly with embedded fragment size, overcoming the surface-area-to-volume-ratio error typical of many embedding methods. We anticipate that this method may lead to a low-scaling, high accuracy treatment of electron correlation in large molecular systems.

Consensus embedding: theory, algorithms and application to segmentation and classification of biomedical data

Directory of Open Access Journals (Sweden)

Viswanath Satish

2012-02-01

Full Text Available Abstract Background Dimensionality reduction (DR enables the construction of a lower dimensional space (embedding from a higher dimensional feature space while preserving object-class discriminability. However several popular DR approaches suffer from sensitivity to choice of parameters and/or presence of noise in the data. In this paper, we present a novel DR technique known as consensus embedding that aims to overcome these problems by generating and combining multiple low-dimensional embeddings, hence exploiting the variance among them in a manner similar to ensemble classifier schemes such as Bagging. We demonstrate theoretical properties of consensus embedding which show that it will result in a single stable embedding solution that preserves information more accurately as compared to any individual embedding (generated via DR schemes such as Principal Component Analysis, Graph Embedding, or Locally Linear Embedding. Intelligent sub-sampling (via mean-shift and code parallelization are utilized to provide for an efficient implementation of the scheme. Results Applications of consensus embedding are shown in the context of classification and clustering as applied to: (1 image partitioning of white matter and gray matter on 10 different synthetic brain MRI images corrupted with 18 different combinations of noise and bias field inhomogeneity, (2 classification of 4 high-dimensional gene-expression datasets, (3 cancer detection (at a pixel-level on 16 image slices obtained from 2 different high-resolution prostate MRI datasets. In over 200 different experiments concerning classification and segmentation of biomedical data, consensus embedding was found to consistently outperform both linear and non-linear DR methods within all applications considered. Conclusions We have presented a novel framework termed consensus embedding which leverages ensemble classification theory within dimensionality reduction, allowing for application to a wide range

Embedded librarianship what every academic librarian should know

CERN Document Server

Russo, Michael F

2013-01-01

Is the embedded librarian an equal partner in the course, or is the librarian perceived as a "value-added" extra? What is the place of technology in this effort? Is there a line librarians should not cross? Taking into account both theory and practice to discuss multiple facets of the subject, Embedded Librarianship: What Every Academic Librarian Should Know thoroughly examines these questions and more from the perspectives of experienced embedded librarian contributors who have worked in higher education settings. The chapters illuminate the benefits and challenges of embedding, explain the planning required to set up an embedded course, identify the different forms of embedding, and consider information literacy instruction in various contexts. Readers who will benefit from this work include not only academic librarians but any professor who wants their students to be able to do better research in their fields.

Cardiac Progenitor Cell Extraction from Human Auricles

KAUST Repository

Di Nardo, Paolo; Pagliari, Francesca

2017-01-01

by precursor cells mostly embedded into the heart apex and in the atria. We have shown that an elective region of progenitor cell embedding is represented by the auricles, non-contractile atria appendages that can be easily sampled without harming the patient

Multithreading for Embedded Reconfigurable Multicore Systems

NARCIS (Netherlands)

Zaykov, P.G.

2014-01-01

In this dissertation, we address the problem of performance efficient multithreading execution on heterogeneous multicore embedded systems. By heterogeneous multicore embedded systems we refer to those, which have real-time requirements and consist of processor tiles with General Purpose Processor

Multithreading for embedded reconfigurable multicore systems

NARCIS (Netherlands)

Zaykov, P.G.

2014-01-01

In this dissertation, we address the problem of performance efficient multithreading execution on heterogeneous multicore embedded systems. By heterogeneous multicore embedded systems we refer to those, which have real-time requirements and consist of processor tiles with General Purpose Processor

Heterogeneous Embedded Real-Time Systems Environment

Science.gov (United States)

2003-12-01

AFRL-IF-RS-TR-2003-290 Final Technical Report December 2003 HETEROGENEOUS EMBEDDED REAL - TIME SYSTEMS ENVIRONMENT Integrated...HETEROGENEOUS EMBEDDED REAL - TIME SYSTEMS ENVIRONMENT 6. AUTHOR(S) Cosmo Castellano and James Graham 5. FUNDING NUMBERS C - F30602-97-C-0259

Gene Expression Analysis of Immunostained Endothelial Cells Isolated from Formaldehyde-fixated Paraffin Embedded Tumors Using Laser Capture Microdissection – a Technical Report

Science.gov (United States)

Kaneko, Tomoatsu; Okiji, Takashi; Kaneko, Reika; Suda, Hideaki; Nör, Jacques E.

2009-01-01

Laser capture microdissection (LCM) allows microscopic procurement of specific cell types from tissue sections that can then be used for gene expression analysis. In conventional LCM, frozen tissues stained with hematoxylin are normally used to the molecular analysis. Recent studies suggested that it is possible to carry out gene expression analysis of formaldehyde-fixated paraffin embedded (FFPE) tissues that were stained with hematoxylin. However, it is still unclear if quantitative gene expression analyses can be performed from LCM cells from FFPE tissues that were subjected to immunostaining to enhance identification of target cells. In this proof-of-principle study, we analyzed by RT-PCR and real time PCR the expression of genes in factor VIII immunostained human endothelial cells that were dissected from FFPE tissues by LCM. We observed that immunostaining should be performed at 4°C to preserve the mRNA from the cells. The expression of Bcl-2 in the endothelial cells was evaluated by RT-PCR and by real time PCR. GAPDH and 18S were used as house keeping genes for RT-PCR and real time PCR, respectively. This report unveils a method for quantitative gene expression analysis in cells that were identified by immunostaining and retrieved by LCM from FFPE tissues. This method is ideally suited for the analysis of relatively rare cell types within a tissue, and should improve on our ability to perform differential diagnosis of pathologies as compared to conventional LCM. PMID:19425073

The Coarse-Grained/Fine-Grained Logic Interface in FPGAs with Embedded Floating-Point Arithmetic Units

Directory of Open Access Journals (Sweden)

Chi Wai Yu

2008-01-01

Full Text Available This paper examines the interface between fine-grained and coarse-grained programmable logic in FPGAs. Specifically, it presents an empirical study that covers the location, pin arrangement, and interconnect between embedded floating point units (FPUs and the fine-grained logic fabric in FPGAs. It also studies this interface in FPGAs which contain both FPUs and embedded memories. The results show that (1 FPUs should have a square aspect ratio; (2 they should be positioned near the center of the FPGA; (3 their I/O pins should be arranged around all four sides of the FPU; (4 embedded memory should be located between the FPUs; and (5 connecting higher I/O density coarse-grained blocks increases the demand for routing resources. The hybrid FPGAs with embedded memory required 12% wider channels than the case where embedded memory is not used.

Analyzing Software Requirements Errors in Safety-Critical, Embedded Systems

Science.gov (United States)

Lutz, Robyn R.

1993-01-01

This paper analyzes the root causes of safety-related software errors in safety-critical, embedded systems. The results show that software errors identified as potentially hazardous to the system tend to be produced by different error mechanisms than non- safety-related software errors. Safety-related software errors are shown to arise most commonly from (1) discrepancies between the documented requirements specifications and the requirements needed for correct functioning of the system and (2) misunderstandings of the software's interface with the rest of the system. The paper uses these results to identify methods by which requirements errors can be prevented. The goal is to reduce safety-related software errors and to enhance the safety of complex, embedded systems.

Glial Cells: The Other Cells of the Nervous System

Indian Academy of Sciences (India)

pounded the cell theory with M Schleiden, had diverse interests. ... (Courtesy: Dr. Vanaja Shetty, The Foundation for Medical Research, Mumbai) ... Role of Schwann Cells in Myelination ... arrangement of microvilli extending from the Schwann cell embedded in the gap matrix ... Schwann cells Regulate Nerve Development.

Highly conductive porous Na-embedded carbon nanowalls for high-performance capacitive deionization

Science.gov (United States)

Chang, Liang; Hu, Yun Hang

2018-05-01

Highly conductive porous Na-embedded carbon nanowalls (Na@C), which were recently invented, have exhibited excellent performance for dye-sensitized solar cells and electric double-layer capacitors. In this work, Na@C was demonstrated as an excellent electrode material for capacitive deionization (CDI). In a three-electrode configuration system, the specific capacity of the Na@C electrodes can achieve 306.4 F/g at current density of 0.2 A/g in 1 M NaCl, which is higher than that (235.2 F/g) of activated carbon (AC) electrodes. Furthermore, a high electrosorption capacity of 8.75 mg g-1 in 100 mg/L NaCl was obtained with the Na@C electrodes in a batch-mode capacitive deionization cell. It exceeds the electrosorption capacity (4.08 mg g-1) of AC electrodes. The Na@C electrode also showed a promising cycle stability. The excellent performance of Na@C electrode for capacitive deionization (CDI) can be attributed to its high electrical conductivity and large accessible surface area.

Critical points in an algebra of elementary embeddings

OpenAIRE

Dougherty, Randall

1992-01-01

Given two elementary embeddings from the collection of sets of rank less than $\\lambda$ to itself, one can combine them to obtain another such embedding in two ways: by composition, and by applying one to (initial segments of) the other. Hence, a single such nontrivial embedding $j$ generates an algebra of embeddings via these two operations, which satisfies certain laws (for example, application distributes over both composition and application). Laver has shown, among other things, that thi...

Endothelial cells and hematopoiesis: a light microscopic study of fetal, normal, and pathologic human bone marrow in plastic-embedded sections.

Science.gov (United States)

Islam, A; Glomski, C; Henderson, E S

1992-07-01

The origin and morphological identity of hematopoietic progenitor cells, as well as their precursor, the pleuripotential hematopoietic stem cell (HSC), has not been established. Our studies of 2 microns sectioned undecalcified plastic-embedded bone marrow (BM) from healthy human fetuses; normal adults; patients with acute myeloblastic leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic granulocytic leukemia (CGL) in various stages (chronic, accelerated, acute blastic phase, and after autografting); and patients recovering from therapy-induced marrow hypoplasia suggest that proliferative hematopoietic zones exist near the endosteum (endosteal marrow) and the vascular endothelium (capillary and sinus-lining endothelium) and a maturational zone distal to these regions. In some of these areas, morphologically recognizable hematopoietic cells were seen and interpreted as emerging and maturing in a sequential progression, suggesting an origin from the endosteal or endothelial progenitors. In other loci, early hematopoietic cells were seen in close contact with the endosteal or vascular endothelial (VE) cells. This latter relationship suggested that these areas of cellular contact were important and represented sites of cell to cell interaction that may be associated with the liberation of growth factors by endosteal and endothelial cells and their action on hematopoietic progenitor cells. Following treatment-induced hypoplasia, the endosteal and VE cells were seen to modulate, transform, and migrate into the surrounding empty and edematous marrow space as fibroblasts. Later, as hemopoietic regeneration began, clusters of regenerating hematopoietic cells were seen adjacent to bone trabecule (BT) and near the vascular endothelium. We postulate that endosteal and VE cells are the equivalent of embryonal-stage, undifferentiated mesenchyme and, under the appropriate regulatory influence, are capable of modulation and transformation (differentiation) into stromal

Quantitative Analysis of Signaling Networks across Differentially Embedded Tumors Highlights Interpatient Heterogeneity in Human Glioblastoma

Science.gov (United States)

2015-01-01

Glioblastoma multiforme (GBM) is the most aggressive malignant primary brain tumor, with a dismal mean survival even with the current standard of care. Although in vitro cell systems can provide mechanistic insight into the regulatory networks governing GBM cell proliferation and migration, clinical samples provide a more physiologically relevant view of oncogenic signaling networks. However, clinical samples are not widely available and may be embedded for histopathologic analysis. With the goal of accurately identifying activated signaling networks in GBM tumor samples, we investigated the impact of embedding in optimal cutting temperature (OCT) compound followed by flash freezing in LN2 vs immediate flash freezing (iFF) in LN2 on protein expression and phosphorylation-mediated signaling networks. Quantitative proteomic and phosphoproteomic analysis of 8 pairs of tumor specimens revealed minimal impact of the different sample processing strategies and highlighted the large interpatient heterogeneity present in these tumors. Correlation analyses of the differentially processed tumor sections identified activated signaling networks present in selected tumors and revealed the differential expression of transcription, translation, and degradation associated proteins. This study demonstrates the capability of quantitative mass spectrometry for identification of in vivo oncogenic signaling networks from human tumor specimens that were either OCT-embedded or immediately flash-frozen. PMID:24927040

Distributed, Embedded and Real-time Java Systems

CERN Document Server

Wellings, Andy

2012-01-01

Research on real-time Java technology has been prolific over the past decade, leading to a large number of corresponding hardware and software solutions, and frameworks for distributed and embedded real-time Java systems.  This book is aimed primarily at researchers in real-time embedded systems, particularly those who wish to understand the current state of the art in using Java in this domain.  Much of the work in real-time distributed, embedded and real-time Java has focused on the Real-time Specification for Java (RTSJ) as the underlying base technology, and consequently many of the Chapters in this book address issues with, or solve problems using, this framework. Describes innovative techniques in: scheduling, memory management, quality of service and communication systems supporting real-time Java applications; Includes coverage of multiprocessor embedded systems and parallel programming; Discusses state-of-the-art resource management for embedded systems, including Java’s real-time garbage collect...

Development of Embedded Fiber-Optic Evanescent Wave Sensors for Optical Characterization of Graphite Anodes in Lithium-Ion Batteries.

Science.gov (United States)

Ghannoum, AbdulRahman; Nieva, Patricia; Yu, Aiping; Khajepour, Amir

2017-11-29

The development, fabrication, and embedment of fiber-optic evanescent wave sensors (FOEWSs) to monitor the state of charge (SOC) and the state of health (SOH) of lithium-ion batteries (LIBs) are presented. Etching of FOEWSs is performed using a solution of 40 wt % ammonium fluoride (NH 4 F) and 49 wt % hydrofluoric acid (HF) (6:1), which is found to be superior to an etching solution containing just 49 wt % HF. FOEWSs were characterized using glycerol and found to have the highest sensitivity in a lithium-ion battery when they lose 92% of their transmittance in the presence of glycerol on their sensing region. The physical effect that the FOEWS has on the graphite anode is also investigated and is found to be much more significant in Swagelok cells compared to that in in-house-fabricated pouch cells, mainly due to pressure variation. The FOEWS was found to be most sensitive to the changes in the LIB when it was completely embedded using a slurry of graphite anode material within a pouch cell. The optimized fabrication process of the embedded FOEWS demonstrates the potential of using such sensors commercially for real-time monitoring of the SOC and SOH of LIBs while in operation.

Corrosion of metal materials embedded in concrete

International Nuclear Information System (INIS)

Duffo, G.S.; Farina, S.B.; Schulz, F.M.

2010-01-01

Carbon steel is the material most frequently used to strengthen reinforced concrete structures; however, stainless steel and galvanized steel reinforcements are also used in construction concretes; and they are not often used in Latin America. Meanwhile, there are other metals that are embedded in the concrete forming part of the openings (aluminum) or in tubing systems (copper and lead). The use of concrete as a cementing material is also useful for immobilizing wastes, such as for example those generated by the nuclear industry. There is a great deal of research and development on the corrosion of steel reinforcements, but the same is not true for the behavior of other metals embedded in concrete and that also undergo corrosive processes. This work aims to study the corrosion of different metals: copper, lead, aluminum, zinc, stainless steel and carbon steel; embedded in concrete with and without the presence of aggressive species for the metal materials. Test pieces were made of mortar containing rods of different materials for testing, and with chlorides added in concentrations of 0; 0.3 % and 1% (mass of chloride per mass of cement). The test pieces were exposed to different conditions; laboratory environment with a relative humidity (RH) of 45%, a controlled atmosphere with 98% RH and submerged in a solution of 3.5% NaCl. The susceptibility to corrosion of the different metals was evaluated using techniques to monitor the corrosion potential, the resistivity of the mortar and the polarization resistance (PR). The rods were weighed before being placed inside the test pieces to later determine the loss of weight generated by the corrosion process. Polarization curves for the metals were also traced in a simulated pore solution (SPS) and in SPS with added chloride. The results obtained to date show that, of all the metals analyzed, aluminum is the most susceptible to corrosion, and that the test specimens with 0% and 1% of chloride exposed to the laboratory

A mechanically-induced colon cancer cell population shows increased metastatic potential

KAUST Repository

Tang, Xin; Kuhlenschmidt, Theresa B; Li, Qian; Ali, Shahjahan; Lezmi, Stephane; Chen, Hong; Pires-Alves, Melissa; Laegreid, William W; Saif, Taher A; Kuhlenschmidt, Mark S

2014-01-01

Background: Metastasis accounts for the majority of deaths from cancer. Although tumor microenvironment has been shown to have a significant impact on the initiation and/or promotion of metastasis, the mechanism remains elusive. We previously reported that HCT-8 colon cancer cells underwent a phenotypic transition from an adhesive epithelial type (E-cell) to a rounded dissociated type (R-cell) via soft substrate culture, which resembled the initiation of metastasis. The objective of current study was to investigate the molecular and metabolic mechanisms of the E-R transition.Methods: Global gene expressions of HCT-8 E and R cells were measured by RNA Sequencing (RNA-seq); and the results were further confirmed by real-time PCR. Reactive oxygen species (ROS), anoikis resistance, enzyme activity of aldehyde dehydrogenase 3 family, member A1 (ALDH3A1), and in vitro invasion assay were tested on both E and R cells. The deformability of HCT-8 E and R cells was measured by atomic force microscopy (AFM). To study the in vivo invasiveness of two cell types, athymic nude mice were intra-splenically injected with HCT-8 E or R cells and sacrificed after 9 weeks. Incidences of tumor development and metastasis were histologically evaluated and analyzed with Fisher's exact test.Results: Besides HCT-8, E-R transition on soft substrates was also seen in three other cancer cell lines (HCT116, SW480 colon and DU145 prostate cancer). The expression of some genes, such as ALDH3A1, TNS4, CLDN2, and AKR1B10, which are known to play important roles in cancer cell migration, invasion, proliferation and apoptosis, were increased in HCT-8 R cells. R cells also showed higher ALDH3A1 enzyme activity, higher ROS, higher anoikis resistance, and higher softness than E cells. More importantly, in vitro assay and in vivo animal models revealed that HCT-8 R cells were more invasive than E cells.Conclusions: Our comprehensive comparison of HCT-8 E and R cells revealed differences of molecular

A mechanically-induced colon cancer cell population shows increased metastatic potential

KAUST Repository

Tang, Xin

2014-05-29

Background: Metastasis accounts for the majority of deaths from cancer. Although tumor microenvironment has been shown to have a significant impact on the initiation and/or promotion of metastasis, the mechanism remains elusive. We previously reported that HCT-8 colon cancer cells underwent a phenotypic transition from an adhesive epithelial type (E-cell) to a rounded dissociated type (R-cell) via soft substrate culture, which resembled the initiation of metastasis. The objective of current study was to investigate the molecular and metabolic mechanisms of the E-R transition.Methods: Global gene expressions of HCT-8 E and R cells were measured by RNA Sequencing (RNA-seq); and the results were further confirmed by real-time PCR. Reactive oxygen species (ROS), anoikis resistance, enzyme activity of aldehyde dehydrogenase 3 family, member A1 (ALDH3A1), and in vitro invasion assay were tested on both E and R cells. The deformability of HCT-8 E and R cells was measured by atomic force microscopy (AFM). To study the in vivo invasiveness of two cell types, athymic nude mice were intra-splenically injected with HCT-8 E or R cells and sacrificed after 9 weeks. Incidences of tumor development and metastasis were histologically evaluated and analyzed with Fisher\\'s exact test.Results: Besides HCT-8, E-R transition on soft substrates was also seen in three other cancer cell lines (HCT116, SW480 colon and DU145 prostate cancer). The expression of some genes, such as ALDH3A1, TNS4, CLDN2, and AKR1B10, which are known to play important roles in cancer cell migration, invasion, proliferation and apoptosis, were increased in HCT-8 R cells. R cells also showed higher ALDH3A1 enzyme activity, higher ROS, higher anoikis resistance, and higher softness than E cells. More importantly, in vitro assay and in vivo animal models revealed that HCT-8 R cells were more invasive than E cells.Conclusions: Our comprehensive comparison of HCT-8 E and R cells revealed differences of molecular

Radiation induced cell death in cervical squamous cell carcinoma. An immunohistochemical and ultrastructural study

International Nuclear Information System (INIS)

Atari, Eio; Toda, Takayoshi; Sadi, A.M.; Egawa, Haruhiko; Moromizato, Hidehiko; Mamadi, T.; Kiyuna, Masaya

1998-01-01

To study the process of cell death in cervical squamous cell carcinoma (SCC) after radiation, an ultrastructural and immunohistochemical study was performed. Paraffin-embedded tissue blocks of biopsy samples pre- and post-radiation stage III SCC (n=15) were collected. Irradiation caused varying ultrastructural changes including nuclear and cytoplasmic disorganization suggesting cell necrosis. Immunohistochemically, the pre-radiation specimens showed no positive reaction for tumor necrosis factor-alpha (TNF-α), tumor necrosis factor-receptor (TNF-γ) or Fas. C-fos, p53 and bcl-2 showed positive reactions in only a few non-irradiated specimens. All of the irradiated specimens showed a positive reaction for TNF-α, and variable positive reactions were observed for TNF-γ, Fas, p53, c-fos and bcl-2. These results suggest that TNF-α, TNF-γ, and c-fos are responsible for radiation induced cell death in cervical SCC. (author)

Apparatuses And Systems For Embedded Thermoelectric Generators

KAUST Repository

Hussain, Muhammad M.; Inayat, Salman Bin; Smith, Casey Eben

2013-01-01

An apparatus and a system for embedded thermoelectric generators are disclosed. In one embodiment, the apparatus is embedded in an interface where the ambient temperatures on two sides of the interface are different. In one embodiment, the apparatus is fabricated with the interface in integrity as a unitary piece. In one embodiment, the apparatus includes a first thermoelectric material embedded through the interface. The apparatus further includes a second thermoelectric material embedded through the interface. The first thermoelectric material is electrically coupled to the second thermoelectric material. In one embodiment, the apparatus further includes an output structure coupled to the first thermoelectric material and the second thermoelectric material and configured to output a voltage.

Apparatuses And Systems For Embedded Thermoelectric Generators

KAUST Repository

Hussain, Muhammad M.

2013-08-08

An apparatus and a system for embedded thermoelectric generators are disclosed. In one embodiment, the apparatus is embedded in an interface where the ambient temperatures on two sides of the interface are different. In one embodiment, the apparatus is fabricated with the interface in integrity as a unitary piece. In one embodiment, the apparatus includes a first thermoelectric material embedded through the interface. The apparatus further includes a second thermoelectric material embedded through the interface. The first thermoelectric material is electrically coupled to the second thermoelectric material. In one embodiment, the apparatus further includes an output structure coupled to the first thermoelectric material and the second thermoelectric material and configured to output a voltage.

Measuring the Levels of Ribonucleotides Embedded in Genomic DNA.

Science.gov (United States)

Meroni, Alice; Nava, Giulia M; Sertic, Sarah; Plevani, Paolo; Muzi-Falconi, Marco; Lazzaro, Federico

2018-01-01

Ribonucleotides (rNTPs) are incorporated into genomic DNA at a relatively high frequency during replication. They have beneficial effects but, if not removed from the chromosomes, increase genomic instability. Here, we describe a fast method to easily estimate the amounts of embedded ribonucleotides into the genome. The protocol described is performed in Saccharomyces cerevisiae and allows us to quantify altered levels of rNMPs due to different mutations in the replicative polymerase ε. However, this protocol can be easily applied to cells derived from any organism.

Connes' embedding problem and winning strategies for quantum XOR games

Science.gov (United States)

Harris, Samuel J.

2017-12-01

We consider quantum XOR games, defined in the work of Regev and Vidick [ACM Trans. Comput. Theory 7, 43 (2015)], from the perspective of unitary correlations defined in the work of Harris and Paulsen [Integr. Equations Oper. Theory 89, 125 (2017)]. We show that the winning bias of a quantum XOR game in the tensor product model (respectively, the commuting model) is equal to the norm of its associated linear functional on the unitary correlation set from the appropriate model. We show that Connes' embedding problem has a positive answer if and only if every quantum XOR game has entanglement bias equal to the commuting bias. In particular, the embedding problem is equivalent to determining whether every quantum XOR game G with a winning strategy in the commuting model also has a winning strategy in the approximate finite-dimensional model.

The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines.

Directory of Open Access Journals (Sweden)

Francesca Carlini

Full Text Available BACKGROUND: Transposable Elements (TEs comprise nearly 45% of the entire genome and are part of sophisticated regulatory network systems that control developmental processes in normal and pathological conditions. The retroviral/retrotransposon gene machinery consists mainly of Long Interspersed Nuclear Elements (LINEs-1 and Human Endogenous Retroviruses (HERVs that code for their own endogenous reverse transcriptase (RT. Interestingly, RT is typically expressed at high levels in cancer cells. Recent studies report that RT inhibition by non-nucleoside reverse transcriptase inhibitors (NNRTIs induces growth arrest and cell differentiation in vitro and antagonizes growth of human tumors in animal model. In the present study we analyze the anticancer activity of Abacavir (ABC, a nucleoside reverse transcription inhibitor (NRTI, on PC3 and LNCaP prostate cancer cell lines. PRINCIPAL FINDINGS: ABC significantly reduces cell growth, migration and invasion processes, considerably slows S phase progression, induces senescence and cell death in prostate cancer cells. Consistent with these observations, microarray analysis on PC3 cells shows that ABC induces specific and dose-dependent changes in gene expression, involving multiple cellular pathways. Notably, by quantitative Real-Time PCR we found that LINE-1 ORF1 and ORF2 mRNA levels were significantly up-regulated by ABC treatment. CONCLUSIONS: Our results demonstrate the potential of ABC as anticancer agent able to induce antiproliferative activity and trigger senescence in prostate cancer cells. Noteworthy, we show that ABC elicits up-regulation of LINE-1 expression, suggesting the involvement of these elements in the observed cellular modifications.

Exact solutions for isometric embeddings of pseudo-Riemannian manifolds

International Nuclear Information System (INIS)

Amery, G; Moodley, J

2014-01-01

Embeddings into higher dimensions are of direct importance in the study of higher dimensional theories of our Universe, in high energy physics and in classical general relativity. Theorems have been established that guarantee the existence of local and global codimension-1 embeddings between pseudo-Riemannian manifolds, particularly for Einstein embedding spaces. A technique has been provided to determine solutions to such embeddings. However, general solutions have not yet been found and most known explicit solutions are for embedded spaces with relatively simple Ricci curvature. Motivated by this, we have considered isometric embeddings of 4-dimensional pseudo-Riemannian spacetimes into 5-dimensional Einstein manifolds. We have applied the technique to treat specific 4-dimensional cases of interest in astrophysics and cosmology (including the global monopole exterior and Vaidya-de Sitter-class solutions), and provided novel physical insights into, for example, Einstein-Gauss-Bonnet gravity. Since difficulties arise in solving the 5-dimensional equations for given 4-dimensional spaces, we have also investigated embedded spaces, which admit bulks with a particular metric form. These analyses help to provide insight to the general embedding problem

Liquid-Embedded Elastomer Electronics

Science.gov (United States)

Kramer, Rebecca; Majidi, Carmel; Park, Yong-Lae; Paik, Jamie; Wood, Robert

2012-02-01

Hyperelastic sensors are fabricated by embedding a silicone rubber film with microchannels of conductive liquid. In the case of soft tactile sensors, pressing the surface of the elastomer will deform the cross-section of underlying channels and change their electrical resistance. Soft pressure sensors may be employed in a variety of applications. For example, a network of pressure sensors can serve as artificial skin by yielding detailed information about contact pressures. This concept was demonstrated in a hyperelastic keypad, where perpendicular conductive channels form a quasi-planar network within an elastomeric matrix that registers the location, intensity and duration of applied pressure. In a second demonstration, soft curvature sensors were used for joint angle proprioception. Because the sensors are soft and stretchable, they conform to the host without interfering with the natural mechanics of motion. This marked the first use of liquid-embedded elastomer electronics to monitor human or robotic motion. Finally, liquid-embedded elastomers may be implemented as conductors in applications that call for flexible or stretchable circuitry, such as robotic origami.

Potential of indirect evaporative passive cooling with embedded tubes in a humid tropical climate : applications in a typical hot humid climate

Energy Technology Data Exchange (ETDEWEB)

Garcia Chavez, J.R. [Univ. Autonoma Metropolitana-Azcapotzalco, Mexico City (Mexico). Dept. de Medio Ambiente, Laboratorio de Investigaciones en Arquitectura Bioclimatica; Givoni, B. [California Univ., Los Angeles, CA (United States); BGU, Beer Sheva (Israel); Viveros, O. [Cristobal Colon Univ., Veracruz (Mexico)

2009-07-01

The use of passive cooling techniques in buildings in hot and humid regions can reduce energy consumption while increasing thermal comfort for occupants. A study was conducted in the City of Veracruz, Mexico to investigate the performance of tubes embedded in the roof of the Gulf Meteorological Prevision Centre. Two identical insulated experimental cells were used, one serving as the control and the other one as the test unit, where the technique of embedded tubes in the roof was implemented and investigated during a typical overheating season. Results showed that this indirect evaporative cooling system is an effective strategy to reduce indoor temperatures without increasing the indoor humidity in buildings. The indoor maximum temperature was lowered by 2.72 K in the experimental test cell relative to the control unit. In addition, the resulting reduction of radiant temperatures in the test unit improved the thermal comfort of the occupants. It is expected that the implementation of this passive cooling technique will eventually contribute to reduced energy consumption and less use of air-conditioning systems in buildings, and thereby prevent emission of greenhouse gases to the atmosphere. 9 refs., 1 tab., 6 figs.

Modern Embedded Computing Designing Connected, Pervasive, Media-Rich Systems

CERN Document Server

Barry, Peter

2012-01-01

Modern embedded systems are used for connected, media-rich, and highly integrated handheld devices such as mobile phones, digital cameras, and MP3 players. All of these embedded systems require networking, graphic user interfaces, and integration with PCs, as opposed to traditional embedded processors that can perform only limited functions for industrial applications. While most books focus on these controllers, Modern Embedded Computing provides a thorough understanding of the platform architecture of modern embedded computing systems that drive mobile devices. The book offers a comprehen

Video2vec Embeddings Recognize Events When Examples Are Scarce.

Science.gov (United States)

Habibian, Amirhossein; Mensink, Thomas; Snoek, Cees G M

2017-10-01

This paper aims for event recognition when video examples are scarce or even completely absent. The key in such a challenging setting is a semantic video representation. Rather than building the representation from individual attribute detectors and their annotations, we propose to learn the entire representation from freely available web videos and their descriptions using an embedding between video features and term vectors. In our proposed embedding, which we call Video2vec, the correlations between the words are utilized to learn a more effective representation by optimizing a joint objective balancing descriptiveness and predictability. We show how learning the Video2vec embedding using a multimodal predictability loss, including appearance, motion and audio features, results in a better predictable representation. We also propose an event specific variant of Video2vec to learn a more accurate representation for the words, which are indicative of the event, by introducing a term sensitive descriptiveness loss. Our experiments on three challenging collections of web videos from the NIST TRECVID Multimedia Event Detection and Columbia Consumer Videos datasets demonstrate: i) the advantages of Video2vec over representations using attributes or alternative embeddings, ii) the benefit of fusing video modalities by an embedding over common strategies, iii) the complementarity of term sensitive descriptiveness and multimodal predictability for event recognition. By its ability to improve predictability of present day audio-visual video features, while at the same time maximizing their semantic descriptiveness, Video2vec leads to state-of-the-art accuracy for both few- and zero-example recognition of events in video.

Hardware Support for Embedded Java

DEFF Research Database (Denmark)

Schoeberl, Martin

2012-01-01

The general Java runtime environment is resource hungry and unfriendly for real-time systems. To reduce the resource consumption of Java in embedded systems, direct hardware support of the language is a valuable option. Furthermore, an implementation of the Java virtual machine in hardware enables...... worst-case execution time analysis of Java programs. This chapter gives an overview of current approaches to hardware support for embedded and real-time Java....

Molecular Properties through Polarizable Embedding

DEFF Research Database (Denmark)

Olsen, Jógvan Magnus Haugaard; Kongsted, Jacob

2011-01-01

We review the theory related to the calculation of electric and magnetic molecular properties through polarizable embedding. In particular, we derive the expressions for the response functions up to the level of cubic response within the density functional theory-based polarizable embedding (PE......-DFT) formalism. In addition, we discuss some illustrative applications related to the calculation of nuclear magnetic resonance parameters, nonlinear optical properties, and electronic excited states in solution....

A Foundation for Embedded Languages

DEFF Research Database (Denmark)

Rhiger, Morten

2003-01-01

Recent work on embedding object languages into Haskell use "phantom types" (i.e., parameterized types whose parameter does not occur on the right-hand side of the type definition) to ensure that the embedded object-language terms are simply typed. But is it a safe assumption that only simply...... be answered affirmatively for an idealized Haskell-like language and discuss to which extent Haskell can be used as a meta-language....

Embedded computer systems for control applications in EBR-II

International Nuclear Information System (INIS)

Carlson, R.B.; Start, S.E.

1993-01-01

The purpose of this paper is to describe the embedded computer systems approach taken at Experimental Breeder Reactor II (EBR-II) for non-safety related systems. The hardware and software structures for typical embedded systems are presented The embedded systems development process is described. Three examples are given which illustrate typical embedded computer applications in EBR-II

Bubbling and on-off intermittency in bailout embeddings.

Science.gov (United States)

Cartwright, Julyan H E; Magnasco, Marcelo O; Piro, Oreste; Tuval, Idan

2003-07-01

We establish and investigate the conceptual connection between the dynamics of the bailout embedding of a Hamiltonian system and the dynamical regimes associated with the occurrence of bubbling and blowout bifurcations. The roles of the invariant manifold and the dynamics restricted to it, required in bubbling and blowout bifurcating systems, are played in the bailout embedding by the embedded Hamiltonian dynamical system. The Hamiltonian nature of the dynamics is precisely the distinctive feature of this instance of a bubbling or blowout bifurcation. The detachment of the embedding trajectories from the original ones can thus be thought of as transient on-off intermittency, and noise-induced avoidance of some regions of the embedded phase space can be recognized as Hamiltonian bubbling.

Numerical and structural genomic aberrations are reliably detectable in tissue microarrays of formalin-fixed paraffin-embedded tumor samples by fluorescence in-situ hybridization.

Directory of Open Access Journals (Sweden)

Heike Horn

Full Text Available Few data are available regarding the reliability of fluorescence in-situ hybridization (FISH, especially for chromosomal deletions, in high-throughput settings using tissue microarrays (TMAs. We performed a comprehensive FISH study for the detection of chromosomal translocations and deletions in formalin-fixed and paraffin-embedded (FFPE tumor specimens arranged in TMA format. We analyzed 46 B-cell lymphoma (B-NHL specimens with known karyotypes for translocations of IGH-, BCL2-, BCL6- and MYC-genes. Locus-specific DNA probes were used for the detection of deletions in chromosome bands 6q21 and 9p21 in 62 follicular lymphomas (FL and six malignant mesothelioma (MM samples, respectively. To test for aberrant signals generated by truncation of nuclei following sectioning of FFPE tissue samples, cell line dilutions with 9p21-deletions were embedded into paraffin blocks. The overall TMA hybridization efficiency was 94%. FISH results regarding translocations matched karyotyping data in 93%. As for chromosomal deletions, sectioning artefacts occurred in 17% to 25% of cells, suggesting that the proportion of cells showing deletions should exceed 25% to be reliably detectable. In conclusion, FISH represents a robust tool for the detection of structural as well as numerical aberrations in FFPE tissue samples in a TMA-based high-throughput setting, when rigorous cut-off values and appropriate controls are maintained, and, of note, was superior to quantitative PCR approaches.

Ca-Embedded C2N: an efficient adsorbent for CO2 capture.

Science.gov (United States)

Liu, Yuzhen; Meng, Zhaoshun; Guo, Xiaojian; Xu, Genjian; Rao, Dewei; Wang, Yuhui; Deng, Kaiming; Lu, Ruifeng

2017-10-25

Carbon dioxide as a greenhouse gas causes severe impacts on the environment, whereas it is also a necessary chemical feedstock that can be converted into carbon-based fuels via electrochemical reduction. To efficiently and reversibly capture CO 2 , it is important to find novel materials for a good balance between adsorption and desorption. In this study, we performed first-principles calculations and grand canonical Monte Carlo (GCMC) simulations, to systematically study metal-embedded carbon nitride (C 2 N) nanosheets for CO 2 capture. Our first-principles results indicated that Ca atoms can be uniformly trapped in the cavity center of C 2 N structure, while the transition metals (Sc, Ti, V, Cr, Mn, Fe, Co) are favorably embedded in the sites off the center of the cavity. The determined maximum number of CO 2 molecules with strong physisorption showed that Ca-embedded C 2 N monolayer is the most promising CO 2 adsorbent among all considered metal-embedded materials. Moreover, GCMC simulations revealed that at room temperature the gravimetric density for CO 2 adsorbed on Ca-embedded C 2 N reached 50 wt% at 30 bar and 23 wt% at 1 bar, higher than other layered materials, thus providing a satisfactory system for the CO 2 capture and utilization.

Embeddings for the Schwarzschild metric: classification and new results

International Nuclear Information System (INIS)

Paston, S A; Sheykin, A A

2012-01-01

We suggest a method to search the embeddings of Riemannian spaces with a high enough symmetry in a flat ambient space. It is based on a procedure of construction surfaces with a given symmetry. The method is used to classify the embeddings of the Schwarzschild metric which have the symmetry of this solution, and all such embeddings in a six-dimensional ambient space (i.e. a space with a minimal possible dimension) are constructed. Four of the six possible embeddings are already known, while the two others are new. One of the new embeddings is asymptotically flat, while the other embeddings in a six-dimensional ambient space do not have this property. The asymptotically flat embedding can be of use in the analysis of the many-body problem, as well as for the development of gravity description as a theory of a surface in a flat ambient space. (paper)

Charge storage and tunneling mechanism of Ni nanocrystals embedded HfOx film

Science.gov (United States)

Zhu, H. X.; Zhang, T.; Wang, R. X.; Zhang, Y. Y.; Li, L. T.; Qiu, X. Y.

2016-05-01

A nano-floating gate memory structure based on Ni nanocrystals (NCs) embedded HfOx film is deposited by means of radio-frequency magnetron sputtering. Microstructure investigations reveal that self-organized Ni-NCs with diameters of 4-8 nm are well dispersed in amorphous HfOx matrix. Pt/Ni-NCs embedded HfOx/Si/Ag capacitor structures exhibit voltage-dependent capacitance-voltage hysteresis, and a maximum flat-band voltage shift of 1.5 V, corresponding to a charge storage density of 6.0 × 1012 electrons/cm2, is achieved. These capacitor memory cells exhibit good endurance characteristic up to 4 × 104 cycles and excellent retention performance of 105 s, fulfilling the requirements of next generation non-volatile memory devices. Schottky tunneling is proven to be responsible for electrons tunneling in these capacitors.

Virtual Network Embedding via Monte Carlo Tree Search.

Science.gov (United States)

Haeri, Soroush; Trajkovic, Ljiljana

2018-02-01

Network virtualization helps overcome shortcomings of the current Internet architecture. The virtualized network architecture enables coexistence of multiple virtual networks (VNs) on an existing physical infrastructure. VN embedding (VNE) problem, which deals with the embedding of VN components onto a physical network, is known to be -hard. In this paper, we propose two VNE algorithms: MaVEn-M and MaVEn-S. MaVEn-M employs the multicommodity flow algorithm for virtual link mapping while MaVEn-S uses the shortest-path algorithm. They formalize the virtual node mapping problem by using the Markov decision process (MDP) framework and devise action policies (node mappings) for the proposed MDP using the Monte Carlo tree search algorithm. Service providers may adjust the execution time of the MaVEn algorithms based on the traffic load of VN requests. The objective of the algorithms is to maximize the profit of infrastructure providers. We develop a discrete event VNE simulator to implement and evaluate performance of MaVEn-M, MaVEn-S, and several recently proposed VNE algorithms. We introduce profitability as a new performance metric that captures both acceptance and revenue to cost ratios. Simulation results show that the proposed algorithms find more profitable solutions than the existing algorithms. Given additional computation time, they further improve embedding solutions.

Fuel cells show promise as vehicle power source

International Nuclear Information System (INIS)

Anon.

1980-01-01

Fuel-cell-powered vehicles appear to offer great promise for energy-saving, high-efficiency transportation. Fuel cells are both highly efficient (50% thermal efficiency has been demonstrated by some) and non-polluting (water being the main by-product). Dramatic improvements in performance have occurred recently due to aerospace and utility RandD efforts. The primary vehicle considered at workshops of laboratory and industrial investigators was a fuel cell/battery hybrid, in which fuel cells are paralleled by batteries. Fuel cells are used for cruising power and battery recharge, while batteries supply transient power for acceleration and starting

LSB steganography with improved embedding efficiency and undetectability

OpenAIRE

Khalind, Omed; Aziz, Benjamin Yowell Yousif

2015-01-01

In this paper, we propose a new method of non-adapt ive LSB steganography in still images to improve the embedding efficiency from 2 to 8/3 rand om bits per one embedding change even for the embedding rate of 1 bit per pixel. The method t akes 2-bits of the secret message at a time and compares them to the LSBs of the two chosen pix el values for embedding, it always assumes a single mismatch between the two and uses the seco nd LSB o...

Brine migration test performed in the older Halite Na2β formation at the Asse salt mine. Temperature-test field No4(TTF4)

International Nuclear Information System (INIS)

Rothfuchs, T.; Schwarzianek, P.; Feddersen, H.

1984-01-01

A so-called brine migration test was performed in the Older Halite Na2β formation at the Asse salt mine. The test was designed to investigate the rate of thermally induced brine or crystalline water release into a heated borehole. The heat source simulates heat-producing high level radioactive waste. As a heat source a heater of 5,4 m length and 200 mm diameter was used in a 15 m deep vertical borehole. The initial heater power was 9000 Watt. Due to corrosion the heater power decreased during the experiment. The following measuring results were obtained: maximum salt temperature on heating day 137 = 280 0 C; average temperature gradient at the borehole wall on heating day 137 = 49 0 C/7,5 cm; accumulated water release on heating day 688 = 3386 g; pH-value of the condensate in the cool trap = 3; analysis of the borehole atmosphere: - no Cl 2 , SO 2 , HCl, H 2 S; - O 2 max 4%, CO max 0,3%, CO 2 max 12% and CH 4 max 1,3%. In addition to the investigation of the borehole atmosphere measurements of the local principle stresses and of the rock deformations were performed

Unsupervised Document Embedding With CNNs

OpenAIRE

Liu, Chundi; Zhao, Shunan; Volkovs, Maksims

2017-01-01

We propose a new model for unsupervised document embedding. Leading existing approaches either require complex inference or use recurrent neural networks (RNN) that are difficult to parallelize. We take a different route and develop a convolutional neural network (CNN) embedding model. Our CNN architecture is fully parallelizable resulting in over 10x speedup in inference time over RNN models. Parallelizable architecture enables to train deeper models where each successive layer has increasin...

Technical solutions to enable embedded generation growth

Energy Technology Data Exchange (ETDEWEB)

Lynch, C.A.; Todd, S.; Millar, W.; Wood, H.S.

2003-07-01

This report describes the results of one of a series of studies commissioned by the UK Department of Trade and Industry into various aspects of embedded generation with the aim of supporting the development and deployment of electrical sources (particularly their ease of connection to the network) to deliver power to consumers. The first phase of the project involved a literature review and meetings with embedded generation developers and planning engineers from distribution network operators (DNOs). The second phase investigated embedded generation at different levels of the distribution network and included modelling a representative network. Technologies that could facilitate a significant increase in embedded generation were identified and estimates made of when and where significant development would be needed. Technical problems identified by DNOs were concerned with thermal loading, voltage regulation, fault levels, protection and network operation. A number of non-technical (commercial and regulatory) problems were also identified. The report describes the UK regulatory framework, the present situation, the British power system, the accommodation of embedded generation by established means, the representative model and technical innovations.

An Overview of Reconfigurable Hardware in Embedded Systems

Directory of Open Access Journals (Sweden)

Wenyin Fu

2006-09-01

Full Text Available Over the past few years, the realm of embedded systems has expanded to include a wide variety of products, ranging from digital cameras, to sensor networks, to medical imaging systems. Consequently, engineers strive to create ever smaller and faster products, many of which have stringent power requirements. Coupled with increasing pressure to decrease costs and time-to-market, the design constraints of embedded systems pose a serious challenge to embedded systems designers. Reconfigurable hardware can provide a flexible and efficient platform for satisfying the area, performance, cost, and power requirements of many embedded systems. This article presents an overview of reconfigurable computing in embedded systems, in terms of benefits it can provide, how it has already been used, design issues, and hurdles that have slowed its adoption.

Time-dependent potential-functional embedding theory

International Nuclear Information System (INIS)

Huang, Chen; Libisch, Florian; Peng, Qing; Carter, Emily A.

2014-01-01

We introduce a time-dependent potential-functional embedding theory (TD-PFET), in which atoms are grouped into subsystems. In TD-PFET, subsystems can be propagated by different suitable time-dependent quantum mechanical methods and their interactions can be treated in a seamless, first-principles manner. TD-PFET is formulated based on the time-dependent quantum mechanics variational principle. The action of the total quantum system is written as a functional of the time-dependent embedding potential, i.e., a potential-functional formulation. By exploiting the Runge-Gross theorem, we prove the uniqueness of the time-dependent embedding potential under the constraint that all subsystems share a common embedding potential. We derive the integral equation that such an embedding potential needs to satisfy. As proof-of-principle, we demonstrate TD-PFET for a Na 4 cluster, in which each Na atom is treated as one subsystem and propagated by time-dependent Kohn-Sham density functional theory (TDDFT) using the adiabatic local density approximation (ALDA). Our results agree well with a direct TDDFT calculation on the whole Na 4 cluster using ALDA. We envision that TD-PFET will ultimately be useful for studying ultrafast quantum dynamics in condensed matter, where key regions are solved by highly accurate time-dependent quantum mechanics methods, and unimportant regions are solved by faster, less accurate methods

Spectroscopic enhancement in nanoparticles embedded glasses

Energy Technology Data Exchange (ETDEWEB)

Sahar, M. R., E-mail: mrahim057@gmail.com; Ghoshal, S. K., E-mail: mrahim057@gmail.com [Advanced Optical Material Research Group, Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, 81310, Skudai, Johor Bahru, Johor (Malaysia)

2014-09-25

This presentation provides an overview of the recent progress in the enhancement of the spectroscopic characteristics of the glass embedded with nanoparticles (NPs). Some of our research activities with few significantly new results are highlighted and facilely analyzed. The science and technology dealing with the manipulation of the physical properties of rare earth doped inorganic glasses by embedding metallic NPs or nanoclusters produce the so-called 'nanoglass'. Meanwhile, the spectroscopic enhancement relates the intensity of the luminescence measured at certain transition. The enhancement which expectedly due to the 'plasmonics wave' (referring to the coherent coupling of photons to free electron oscillations called plasmon) occurs at the interface between a conductor and a dielectric. Plasmonics being an emerging concept in advanced optical material of nanophotonics has given this material the ability to exploit the optical response at nanoscale and opened up a new avenue in metal-based glass optics. There is a vast array of plasmonic NPs concepts yet to be explored, with applications spanning solar cells, (bio) sensing, communications, lasers, solid-state lighting, waveguides, imaging, optical data transfer, display and even bio-medicine. Localized surface plasmon resonance (LSPR) can enhance the optical response of nanoglass by orders of magnitude as observed. The luminescence enhancement and surface enhanced Raman scattering (SERS) are new paradigm of research. The enhancement of luminescence due to the influence of metallic NPs is the recurring theme of this paper.

Fast and effective embedded systems design applying the ARM mbed

CERN Document Server

Toulson, Rob

2012-01-01

A hands-on introduction to the field of embedded systems; A focus on fast prototyping of embedded systems; All key embedded system concepts covered through simple and effective experimentation; An understanding of ARM technology, one of the world's leaders; A practical introduction to embedded C; Applies possibly the most accessible set of tools available in the embedded world.  This book is an introduction to embedded systems design, using the ARM mbed and C programming language as development tools. The mbed provides a compact, self-contained and low-cost hardware core, and the

Determination of the cell tropism of serotype 1 feline infectious peritonitis virus using the spike affinity histochemistry in paraffin-embedded tissues.

Science.gov (United States)

Cham, Tat-Chuan; Chang, Yen-Chen; Tsai, Pei-Shiue; Wu, Ching-Ho; Chen, Hui-Wen; Jeng, Chian-Ren; Pang, Victor Fei; Chang, Hui-Wen

2017-08-01

Unlike for serotype II feline coronaviruses (FCoV II), the cellular receptor for serotype I FCoV (FCoV I), the most prevalent FCoV serotype, is unknown. To provide a platform for assessing the pattern by which FCoV I attaches to its host receptor(s), HEK293 cell lines that stably express the ectodomains of the spike (S) proteins derived from a FCoV I feline enteric coronavirus strain UU7 (FECV UU7) and a feline infectious peritonitis virus strain UU4 (FIPV UU4) were established. Using the recombinant S proteins as probes to perform S protein affinity histochemistry in paraffin-embedded tissues, although no tissue or enteric binding of FECV UU7 S protein was detected, it was found that by immunohistochemistry that the tissue distribution of FIPV UU4 S protein-bound cells correlated with that of FIPV antigen-positive cells and lesions associated with FIP and that the affinity binding of FIPV UU4 S protein on macrophages was not affected by enzymatic removal of host cell-surface sialic acid with neuraminidase. These findings suggest that a factor(s) other than sialic acid contribute(s) to the macrophage tropism of FIPV strain UU4. This approach allowed obtaining more information about both virus-host cell interactions and the biological characteristics of the unidentified cellular receptor for FCoV I. © 2017 The Societies and John Wiley & Sons Australia, Ltd.

Connecting embedded and stand-alone peer mentoring models to enhance student engagement

Directory of Open Access Journals (Sweden)

Rhys Cooper

2018-03-01

Full Text Available This paper outlines the Trident Student Mentoring Program that runs in the College of Engineering at Victoria University, Melbourne, Australia. The program offers both embedded and stand-alone models of peer mentoring services to the same cohort of first-year students. It shows that by forming strong links between these two types of peer mentoring models, the inherent challenges of both, such as low attendance rates in stand-alone models and short periods of peer to peer time in embedded models, are mitigated.

The miniaturized Raman system and detection of traces of life in halite from the Atacama Desert: some considerations for the search for life signatures on Mars.

Science.gov (United States)

Vítek, Petr; Jehlička, Jan; Edwards, Howell G M; Hutchinson, Ian; Ascaso, Carmen; Wierzchos, Jacek

2012-12-01

Raman spectroscopy is being adopted as a nondestructive instrumentation for the robotic exploration of Mars to search for traces of life in the geological record. Here, miniaturized Raman spectrometers of two different types equipped with 532 and 785 nm lasers for excitation, respectively, were compared for the detection of microbial biomarkers in natural halite from the hyperarid region of the Atacama Desert. Measurements were performed directly on the rock as well as on the homogenized, powdered samples prepared from this material-the effects of this sample preparation and the excitation wavelength employed in the analysis are compared and discussed. From these results, 532 nm excitation was found to be superior for the analysis of powdered specimens due to its high sensitivity toward carotenoids and hence a higher capability for their detection at relatively low concentration in bulk powdered specimens. For the same reason, this wavelength was a better choice for the detection of carotenoids in direct measurements made on the rock samples. The 785 nm excitation wavelength, in contrast, proved to be more sensitive toward the detection of scytonemin.

Hybrid Message-Embedded Cipher Using Logistic Map

OpenAIRE

Mishra, Mina; Mankar, V. H.

2012-01-01

The proposed hybrid message embedded scheme consists of hill cipher combined with message embedded chaotic scheme. Message-embedded scheme using non-linear feedback shift register as non-linear function and 1-D logistic map as chaotic map is modified, analyzed and tested for avalanche property and strength against known plaintext attack and brute-force attack. Parameter of logistic map acts as a secret key. As we know that the minimum key space to resist brute-force attack is 2100, and it is ...

SPARQL for Networks of Embedded Systems

OpenAIRE

Boldt, Dennis; Hasemann, Henning; Kröller, Alexander; Karnstedt, Marcel; von der Weth, Christian

2014-01-01

The Semantic Web (or Web of Data) represents the successful efforts towards linking and sharing data over the Web. The cornerstones of the Web of Data are RDF as data format and SPARQL as de-facto standard query language. Recent trends show the evolution of the Web of Data towards the Web of Things, integrating embedded devices and smart objects. Data stemming from such devices do not share a common format, making the integration and querying impossible. To overcome this problem, we present o...

Integrated Design and Implementation of Embedded Control Systems with Scilab.

Science.gov (United States)

Ma, Longhua; Xia, Feng; Peng, Zhe

2008-09-05

Embedded systems are playing an increasingly important role in control engineering. Despite their popularity, embedded systems are generally subject to resource constraints and it is therefore difficult to build complex control systems on embedded platforms. Traditionally, the design and implementation of control systems are often separated, which causes the development of embedded control systems to be highly timeconsuming and costly. To address these problems, this paper presents a low-cost, reusable, reconfigurable platform that enables integrated design and implementation of embedded control systems. To minimize the cost, free and open source software packages such as Linux and Scilab are used. Scilab is ported to the embedded ARM-Linux system. The drivers for interfacing Scilab with several communication protocols including serial, Ethernet, and Modbus are developed. Experiments are conducted to test the developed embedded platform. The use of Scilab enables implementation of complex control algorithms on embedded platforms. With the developed platform, it is possible to perform all phases of the development cycle of embedded control systems in a unified environment, thus facilitating the reduction of development time and cost.

Integrated Design and Implementation of Embedded Control Systems with Scilab

Directory of Open Access Journals (Sweden)

Zhe Peng

2008-09-01

Full Text Available Embedded systems are playing an increasingly important role in control engineering. Despite their popularity, embedded systems are generally subject to resource constraints and it is therefore difficult to build complex control systems on embedded platforms. Traditionally, the design and implementation of control systems are often separated, which causes the development of embedded control systems to be highly timeconsuming and costly. To address these problems, this paper presents a low-cost, reusable, reconfigurable platform that enables integrated design and implementation of embedded control systems. To minimize the cost, free and open source software packages such as Linux and Scilab are used. Scilab is ported to the embedded ARM-Linux system. The drivers for interfacing Scilab with several communication protocols including serial, Ethernet, and Modbus are developed. Experiments are conducted to test the developed embedded platform. The use of Scilab enables implementation of complex control algorithms on embedded platforms. With the developed platform, it is possible to perform all phases of the development cycle of embedded control systems in a unified environment, thus facilitating the reduction of development time and cost.

Design optimization of embedded ultrasonic transducers for concrete structures assessment.

Science.gov (United States)

Dumoulin, Cédric; Deraemaeker, Arnaud

2017-08-01

In the last decades, the field of structural health monitoring and damage detection has been intensively explored. Active vibration techniques allow to excite structures at high frequency vibrations which are sensitive to small damage. Piezoelectric PZT transducers are perfect candidates for such testing due to their small size, low cost and large bandwidth. Current ultrasonic systems are based on external piezoelectric transducers which need to be placed on two faces of the concrete specimen. The limited accessibility of in-service structures makes such an arrangement often impractical. An alternative is to embed permanently low-cost transducers inside the structure. Such types of transducers have been applied successfully for the in-situ estimation of the P-wave velocity in fresh concrete, and for crack monitoring. Up to now, the design of such transducers was essentially based on trial and error, or in a few cases, on the limitation of the acoustic impedance mismatch between the PZT and concrete. In the present study, we explore the working principles of embedded piezoelectric transducers which are found to be significantly different from external transducers. One of the major challenges concerning embedded transducers is to produce very low cost transducers. We show that a practical way to achieve this imperative is to consider the radial mode of actuation of bulk PZT elements. This is done by developing a simple finite element model of a piezoelectric transducer embedded in an infinite medium. The model is coupled with a multi-objective genetic algorithm which is used to design specific ultrasonic embedded transducers both for hard and fresh concrete monitoring. The results show the efficiency of the approach and a few designs are proposed which are optimal for hard concrete, fresh concrete, or both, in a given frequency band of interest. Copyright © 2017 Elsevier B.V. All rights reserved.

Heteromeric Slick/Slack K+ channels show graded sensitivity to cell volume changes

DEFF Research Database (Denmark)

Tejada, Maria A; Hashem, Nadia; Callø, Kirstine

2017-01-01

Slick and Slack high-conductance K+ channels are found in the CNS, kidneys, pancreas, among other organs, where they play an important role in cell excitability as well as in ion transport processes. They are both activated by Na+ and Cl- but show a differential regulation by cell volume changes....... Slick has been shown to be regulated by cell volume changes, whereas Slack is insensitive. α-subunits of these channels form homomeric as well as heteromeric channels. It is the aim of this work to explore whether the subunit composition of the Slick/Slack heteromeric channel affects the response...... to osmotic challenges. In order to provide with the adequate water permeability to the cell membrane of Xenopus laevis oocytes, mRNA of aquaporin 1 was co-expressed with homomeric or heteromeric Slick and Slack α-subunits. Oocytes were superfused with hypotonic or hypertonic buffers and changes in currents...

Fluid Distribution in Synthetic Wet Halite Rocks : Inference from Measured Elastic Wave Velocity and Electrical Conductivity

Science.gov (United States)

Watanabe, T.; Kitano, M.

2011-12-01

Intercrystalline fluid can significantly affect rheological and transport properties of rocks. Its influences are strongly dependent on its distribution. The dihedral angle between solid and liquid phases has been widely accepted as a key parameter that controls solid-liquid textures. The liquid phase is not expected to be interconnected if the dihedral angle is larger than 60 degree. However, observations contradictory to dihedral angle values have been reported. Watanabe (2010) suggested the coexistence of grain boundary fluid with a positive dihedral angle. For good understanding of fluid distribution, it is thus critical to study the nature of grain boundary fluid. We have developed a high pressure and temperature apparatus for study of intercrystalline fluid distribution. It was specially designed for measurements of elastic wave velocities and electrical conductivity. The apparatus mainly consists of a conventional cold-seal vessel with an external heater. The pressure medium is silicon oil of the viscosity of 0.1 Pa s. The pressure and temperature can be controlled from 0 to 200 MPa and from 20 to 200 C, respectively. Dimensions of a sample are 9 mm in diameter, and 15 mm in length. Halite-water system is used as an analog for crustal rocks. The dihedral angle has been studied systematically at various pressure and temperature conditions [Lewis and Holness, 1996]. The dihedral angle is larger than 60 degree at lower pressure and temperature. It decreases to be smaller than 60 degree with increasing pressure and temperature. A sample is prepared by cold-pressing and annealing of wet NaCl powder. Optical examination has shown that synthesized samples are microstructurally homogeneous. Grains are polygonal and equidimensional with a mean diameter of 100 micrometer. Grain boundaries vary from straight to bowed and 120 degree triple junctions are common. Gas and fluid bearing inclusions are visible on the grain boundaries. There are spherical inclusions or

Searching for Organics Preserved in 4.5 Billion Year Old Salt

Science.gov (United States)

Zolensky, Michael E.; Fries, M.; Steele, A.; Bodnar, R.

2012-01-01

Our understanding of early solar system fluids took a dramatic turn a decade ago with the discovery of fluid inclusion-bearing halite (NaCl) crystals in the matrix of two freshly fallen brecciated H chondrite falls, Monahans and Zag. Both meteorites are regolith breccias, and contain xenolithic halite (and minor admixed sylvite -- KCl, crystals in their regolith lithologies. The halites are purple to dark blue, due to the presence of color centers (electrons in anion vacancies) which slowly accumulated as 40K (in sylvite) decayed over billions of years. The halites were dated by K-Ar, Rb-Sr and I-Xe systematics to be 4.5 billion years old. The "blue" halites were a fantastic discovery for the following reasons: (1) Halite+sylvite can be dated (K is in sylvite and will substitute for Na in halite, Rb substitutes in halite for Na, and I substitutes for Cl). (2) The blue color is lost if the halite dissolves on Earth and reprecipitates (because the newly-formed halite has no color centers), so the color serves as a "freshness" or pristinity indicator. (3) Halite frequently contains aqueous fluid inclusions. (4) Halite contains no structural oxygen, carbon or hydrogen, making them ideal materials to measure these isotopic systems in any fluid inclusions. (5) It is possible to directly measure fluid inclusion formation temperatures, and thus directly measure the temperature of the mineralizing aqueous fluid. In addition to these two ordinary chondrites halite grains have been reliably reported in several ureilites, an additional ordinary chondrite (Jilin), and in the carbonaceous chondrite (Murchison), although these reports were unfortunately not taken seriously. We have lately found additional fluid inclusions in carbonates in several additional carbonaceous chondrites. Meteoritic aqueous fluid inclusions are apparently relatively widespread in meteorites, though very small and thus difficult to analyze.

Stem cells show promising results for lymphoedema treatment

DEFF Research Database (Denmark)

Toyserkani, Navid Mohamadpour; Quaade, Marlene Louise; Sheikh, Søren Paludan

2015-01-01

Abstract Lymphoedema is a debilitating condition, manifesting in excess lymphatic fluid and swelling of subcutaneous tissues. Lymphoedema is as of yet still an incurable condition and current treatment modalities are not satisfactory. The capacity of mesenchymal stem cells to promote angiogenesis......, secrete growth factors, regulate the inflammatory process, and differentiate into multiple cell types make them a potential ideal therapy for lymphoedema. Adipose tissue is the richest and most accessible source of mesenchymal stem cells and they can be harvested, isolated, and used for therapy...... in a single stage procedure as an autologous treatment. The aim of this paper was to review all studies using mesenchymal stem cells for lymphoedema treatment with a special focus on the potential use of adipose-derived stem cells. A systematic search was performed and five preclinical and two clinical...

Energy-aware virtual network embedding in flexi-grid optical networks

Science.gov (United States)

Lin, Rongping; Luo, Shan; Wang, Haoran; Wang, Sheng; Chen, Bin

2018-01-01

Virtual network embedding (VNE) problem is to map multiple heterogeneous virtual networks (VN) on a shared substrate network, which mitigate the ossification of the substrate network. Meanwhile, energy efficiency has been widely considered in the network design. In this paper, we aim to solve the energy-aware VNE problem in flexi-grid optical networks. We provide an integer linear programming (ILP) formulation to minimize the power increment of each arriving VN request. We also propose a polynomial-time heuristic algorithm where virtual links are embedded sequentially to keep a reasonable acceptance ratio and maintain a low energy consumption. Numerical results show the functionality of the heuristic algorithm in a 24-node network.

Asymmetrical edges induced strong current-polarization in embedded graphene nanoribbons

Science.gov (United States)

Li, Kuanhong; Zhang, Xiang-Hua

2018-05-01

We investigate the electronic structures and transport properties of the embedded zigzag graphene nanoribbon (E-ZGNR) in hexagonal boron nitride trenches, which are achievable in recent experiments. Our first principles results show that the E-ZGNR has a significant enhanced conductivity relative to common ZGNRs due to the existence of asymmetrical edge structures. Moreover, only one spin-orientation electrons possess a widely opened band gap at the magnetic ground state with anti-ferromagnetic configuration, resulting in a full current-polarization at low bias region. Our findings indicate that the state-of-the-art embedding technology is quite useful for tuning the electronic structure of ZGNR and building possible spin injection and spin filter devices in spintronics.

Stability of Moonlets Embedded in Rings

Science.gov (United States)

Lewis, Mark C.; Burdon, C.

2011-04-01

Previous work on moonlets assumed that they were just a single indestructible spherical particle and focused primarily on the effects such a body would have on the surrounding ring material (Lewis and Stewart 2009, Icarus 199:387-412; Sremcevic et al. 2007, Nature 449:1019-1021). Both observations and numerical simulations of Saturn's small inner moons show them as very low density rubble piles (Porco et al. 2007, Science 318:1602). Unlike the small moons, moonlets embedded in the ring material will experience regular collisions with self gravity wakes tens of meters across. Even with a single spherical core, these collisions can lead to the shedding of significant amounts of accreted material. We describe numerical simulations in which we explore the parameters required for stability of moonlets embedded in the ring material. Because of their location well inside the Roche limit, these bodies require either higher densities or some internal strength in order to stay together. We explore how much strength is required for these moonlets to be stable against the regular impacts they sustain in that environment. This work was funded by NSF AAG award number 0907972.

Autonomous Multicamera Tracking on Embedded Smart Cameras

Directory of Open Access Journals (Sweden)

Bischof Horst

2007-01-01

Full Text Available There is currently a strong trend towards the deployment of advanced computer vision methods on embedded systems. This deployment is very challenging since embedded platforms often provide limited resources such as computing performance, memory, and power. In this paper we present a multicamera tracking method on distributed, embedded smart cameras. Smart cameras combine video sensing, processing, and communication on a single embedded device which is equipped with a multiprocessor computation and communication infrastructure. Our multicamera tracking approach focuses on a fully decentralized handover procedure between adjacent cameras. The basic idea is to initiate a single tracking instance in the multicamera system for each object of interest. The tracker follows the supervised object over the camera network, migrating to the camera which observes the object. Thus, no central coordination is required resulting in an autonomous and scalable tracking approach. We have fully implemented this novel multicamera tracking approach on our embedded smart cameras. Tracking is achieved by the well-known CamShift algorithm; the handover procedure is realized using a mobile agent system available on the smart camera network. Our approach has been successfully evaluated on tracking persons at our campus.

MEDIC: medical embedded device for individualized care.

Science.gov (United States)

Wu, Winston H; Bui, Alex A T; Batalin, Maxim A; Au, Lawrence K; Binney, Jonathan D; Kaiser, William J

2008-02-01

Presented work highlights the development and initial validation of a medical embedded device for individualized care (MEDIC), which is based on a novel software architecture, enabling sensor management and disease prediction capabilities, and commercially available microelectronic components, sensors and conventional personal digital assistant (PDA) (or a cell phone). In this paper, we present a general architecture for a wearable sensor system that can be customized to an individual patient's needs. This architecture is based on embedded artificial intelligence that permits autonomous operation, sensor management and inference, and may be applied to a general purpose wearable medical diagnostics. A prototype of the system has been developed based on a standard PDA and wireless sensor nodes equipped with commercially available Bluetooth radio components, permitting real-time streaming of high-bandwidth data from various physiological and contextual sensors. We also present the results of abnormal gait diagnosis using the complete system from our evaluation, and illustrate how the wearable system and its operation can be remotely configured and managed by either enterprise systems or medical personnel at centralized locations. By using commercially available hardware components and software architecture presented in this paper, the MEDIC system can be rapidly configured, providing medical researchers with broadband sensor data from remote patients and platform access to best adapt operation for diagnostic operation objectives.

Self-Organization in Embedded Real-Time Systems

CERN Document Server

Brinkschulte, Uwe; Rettberg, Achim

2013-01-01

This book describes the emerging field of self-organizing, multicore, distributed and real-time embedded systems.  Self-organization of both hardware and software can be a key technique to handle the growing complexity of modern computing systems. Distributed systems running hundreds of tasks on dozens of processors, each equipped with multiple cores, requires self-organization principles to ensure efficient and reliable operation. This book addresses various, so-called Self-X features such as self-configuration, self-optimization, self-adaptation, self-healing and self-protection. Presents open components for embedded real-time adaptive and self-organizing applications; Describes innovative techniques in: scheduling, memory management, quality of service, communications supporting organic real-time applications; Covers multi-/many-core embedded systems supporting real-time adaptive systems and power-aware, adaptive hardware and software systems; Includes case studies of open embedded real-time self-organizi...

Soft-error tolerance and energy consumption evaluation of embedded computer with magnetic random access memory in practical systems using computer simulations

Science.gov (United States)

Nebashi, Ryusuke; Sakimura, Noboru; Sugibayashi, Tadahiko

2017-08-01

We evaluated the soft-error tolerance and energy consumption of an embedded computer with magnetic random access memory (MRAM) using two computer simulators. One is a central processing unit (CPU) simulator of a typical embedded computer system. We simulated the radiation-induced single-event-upset (SEU) probability in a spin-transfer-torque MRAM cell and also the failure rate of a typical embedded computer due to its main memory SEU error. The other is a delay tolerant network (DTN) system simulator. It simulates the power dissipation of wireless sensor network nodes of the system using a revised CPU simulator and a network simulator. We demonstrated that the SEU effect on the embedded computer with 1 Gbit MRAM-based working memory is less than 1 failure in time (FIT). We also demonstrated that the energy consumption of the DTN sensor node with MRAM-based working memory can be reduced to 1/11. These results indicate that MRAM-based working memory enhances the disaster tolerance of embedded computers.

Embedded data representations

DEFF Research Database (Denmark)

Willett, Wesley; Jansen, Yvonne; Dragicevic, Pierre

2017-01-01

We introduce embedded data representations, the use of visual and physical representations of data that are deeply integrated with the physical spaces, objects, and entities to which the data refers. Technologies like lightweight wireless displays, mixed reality hardware, and autonomous vehicles...

Two diverse models of embedding class one

Science.gov (United States)

Kuhfittig, Peter K. F.

2018-05-01

Embedding theorems have continued to be a topic of interest in the general theory of relativity since these help connect the classical theory to higher-dimensional manifolds. This paper deals with spacetimes of embedding class one, i.e., spacetimes that can be embedded in a five-dimensional flat spacetime. These ideas are applied to two diverse models, a complete solution for a charged wormhole admitting a one-parameter group of conformal motions and a new model to explain the flat rotation curves in spiral galaxies without the need for dark matter.

Secure smart embedded devices, platforms and applications

CERN Document Server

Markantonakis, Konstantinos

2013-01-01

New generations of IT users are increasingly abstracted from the underlying devices and platforms that provide and safeguard their services. As a result they may have little awareness that they are critically dependent on the embedded security devices that are becoming pervasive in daily modern life. Secure Smart Embedded Devices, Platforms and Applications provides a broad overview of the many security and practical issues of embedded devices, tokens, and their operation systems, platforms and main applications. It also addresses a diverse range of industry/government initiatives and consider

Modelling Field Bus Communications in Mixed-Signal Embedded Systems

Directory of Open Access Journals (Sweden)

Alassir Mohamad

2008-01-01

Full Text Available Abstract We present a modelling platform using the SystemC-AMS language to simulate field bus communications for embedded systems. Our platform includes the model of an I/O controller IP (in this specific case an C controller that interfaces a master microprocessor with its peripherals on the field bus. Our platform shows the execution of the embedded software and its analog response on the lines of the bus. Moreover, it also takes into account the influence of the circuits's I/O by including their IBIS models in the SystemC-AMS description, as well as the bus lines imperfections. Finally, we present simulation results to validate our platform and measure the overhead introduced by SystemC-AMS over a pure digital SystemC simulation.

Modelling Field Bus Communications in Mixed-Signal Embedded Systems

Directory of Open Access Journals (Sweden)

Patrick Garda

2008-08-01

Full Text Available We present a modelling platform using the SystemC-AMS language to simulate field bus communications for embedded systems. Our platform includes the model of an I/O controller IP (in this specific case an I2C controller that interfaces a master microprocessor with its peripherals on the field bus. Our platform shows the execution of the embedded software and its analog response on the lines of the bus. Moreover, it also takes into account the influence of the circuits's I/O by including their IBIS models in the SystemC-AMS description, as well as the bus lines imperfections. Finally, we present simulation results to validate our platform and measure the overhead introduced by SystemC-AMS over a pure digital SystemC simulation.

Development of an Erlang System Adaopted to Embedded Devices

OpenAIRE

Andersson, Fredrik; Bergström, Fabian

2011-01-01

Erlang is a powerful and robust language for writing massively parallel and distributed applications. With the introduction of multi-core ARM processors, the embedded market will be looking for ways of taking advantage of the newfound opportunities for parallelism. To support the development of embedded applications using Erlang we want to provide Erlang and Embedded developers with a run-time system suited for embedded devices. We have managed to shrink the disk size of the Erlang runtime sy...

ADAPTIVE METHODS FOR STOCHASTIC DIFFERENTIAL EQUATIONS VIA NATURAL EMBEDDINGS AND REJECTION SAMPLING WITH MEMORY.

Science.gov (United States)

Rackauckas, Christopher; Nie, Qing

2017-01-01

Adaptive time-stepping with high-order embedded Runge-Kutta pairs and rejection sampling provides efficient approaches for solving differential equations. While many such methods exist for solving deterministic systems, little progress has been made for stochastic variants. One challenge in developing adaptive methods for stochastic differential equations (SDEs) is the construction of embedded schemes with direct error estimates. We present a new class of embedded stochastic Runge-Kutta (SRK) methods with strong order 1.5 which have a natural embedding of strong order 1.0 methods. This allows for the derivation of an error estimate which requires no additional function evaluations. Next we derive a general method to reject the time steps without losing information about the future Brownian path termed Rejection Sampling with Memory (RSwM). This method utilizes a stack data structure to do rejection sampling, costing only a few floating point calculations. We show numerically that the methods generate statistically-correct and tolerance-controlled solutions. Lastly, we show that this form of adaptivity can be applied to systems of equations, and demonstrate that it solves a stiff biological model 12.28x faster than common fixed timestep algorithms. Our approach only requires the solution to a bridging problem and thus lends itself to natural generalizations beyond SDEs.

Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage

DEFF Research Database (Denmark)

Skovgaard, T; Rasmussen, Lene Juel; Munch-Petersen, Birgitte

2010-01-01

Balanced deoxynucleotide pools are known to be important for correct DNA repair, and deficiency for some of the central enzymes in deoxynucleotide metabolism can cause imbalanced pools, which in turn can lead to mutagenesis and cell death. Here we show that cells deficient for the thymidine salva...

Embedding methods for phi4-interaction

International Nuclear Information System (INIS)

Hanckowiak, J.

1985-01-01

The idea of embedding a given theory in a class of similar theories is applied to quantum field theory in the case of phi 4 -interaction to derive different equations for the generating functional. The number of possible embeddings has been restricted by demanding that for the defined projections of the generating functional a closed system of equations be obtained

Embedded Systems Design with 8051 Microcontrollers

DEFF Research Database (Denmark)

Karakahayov, Zdravko; Winther, Ole; Christensen, Knud Smed

Textbook on embedded microcontrollers. Example microcontroller family: Intel 8051 with special emphasis on Philips 80C552. Structure, design examples and programming in C and assembler. Hardware - software codesign. EProm emulator.......Textbook on embedded microcontrollers. Example microcontroller family: Intel 8051 with special emphasis on Philips 80C552. Structure, design examples and programming in C and assembler. Hardware - software codesign. EProm emulator....

Study of interface influence on bending performance of CFRP with embedded optical fibers

Science.gov (United States)

Liu, Rong-mei; Liang, Da-kai

2008-11-01

Studies showed that the bending strength of composite would be affected by embedded optical fibers. Interface strength between the embedded optical fiber and the matrix was studied in this paper. Based on the single fiber pull out tests, the interfacial shear strength between the coating and the clad is the weakest. The shear strength of the optical fiber used in this study is near to 0.8MPa. In order to study the interfacial effect on bending property of generic smart structure, a quasi-isotropic composite laminates were produced from Toray T300C/ epoxy prepreg. Optical fibers were embedded within different orientation plies of the plates, with the optical fibers embedded in the same direction. Accordingly, five different types of plates were produced. Impact tests were carried out on the 5 different plate types. It is shown that when the fiber was embedded at the upper layer, the bending strength drops mostly. The bending normal stress on material arrives at the maximum. So does the normal stress applied on the optical fiber at the surface. Therefore, destructions could originate at the interface between the coating and the clad foremost. The ultimate strength of the smart structure will be affected furthest.

Automated Extraction of Formalin-Fixed, Paraffin-Embedded Tissue for High-Risk Human Papillomavirus Testing of Head and Neck Squamous Cell Carcinomas Using the Roche Cobas 4800 System.

Science.gov (United States)

Kerr, Darcy A; Sweeney, Brenda; Arpin, Ronald N; Ring, Melissa; Pitman, Martha B; Wilbur, David C; Faquin, William C

2016-08-01

-Testing for high-risk human papillomavirus (HR-HPV) in head and neck squamous cell carcinomas (HNSCCs) is important for both prognostication and clinical management. Several testing platforms are available for HR-HPV; however, effective alternative automated approaches are needed. -To assess the performance of the automated Roche cobas 4800 HPV real-time polymerase chain reaction-based system on formalin-fixed, paraffin-embedded HNSCC specimens and compare results with standard methods of in situ hybridization (ISH) and p16 immunohistochemistry. -Formalin-fixed, paraffin-embedded samples of HNSCC were collected from archival specimens in the Department of Pathology, Massachusetts General Hospital (Boston), and prepared using the automated system by deparaffinization and dehydration followed by tissue lysis. Samples were integrated into routine cervical cytology testing runs by cobas. Corresponding formalin-fixed, paraffin-embedded samples were evaluated for HR-HPV by ISH and p16 by immunohistochemistry. Discrepant cases were adjudicated by polymerase chain reaction. -Sixty-two HNSCC samples were analyzed using the automated cobas system, ISH, and immunohistochemistry. Fifty-two percent (n = 32 of 62) of formalin-fixed, paraffin-embedded tumors were positive for HR-HPV by cobas. Eighty-eight percent (n = 28 of 32) of cases were the HPV 16 subtype and 12% (n = 4 of 32) were other HR-HPV subtypes. Corresponding testing with ISH was concordant in 92% (n = 57 of 62) of cases. Compared with the adjudication polymerase chain reaction standard, there were 3 false-positive cases by cobas. -Concordance in HNSCC HR-HPV status between cobas and ISH was more than 90%. The cobas demonstrated a sensitivity of 100% and a specificity of 91% for detection of HR-HPV. Advantages favoring cobas include its automation, cost efficiency, objective results, and ease of performance.

ASSESSMENT OF SEISMIC ANALYSIS METHODOLOGIES FOR DEEPLY EMBEDDED NPP STRUCTURES

International Nuclear Information System (INIS)

XU, J.; MILLER, C.; COSTANTINO, C.; HOFMAYER, C.; GRAVES, H. NRC.

2005-01-01

Several of the new generation nuclear power plant designs have structural configurations which are proposed to be deeply embedded. Since current seismic analysis methodologies have been applied to shallow embedded structures (e.g., ASCE 4 suggest that simple formulations may be used to model embedment effect when the depth of embedment is less than 30% of its foundation radius), the US Nuclear Regulatory Commission is sponsoring a program at the Brookhaven National Laboratory with the objective of investigating the extent to which procedures acceptable for shallow embedment depths are adequate for larger embedment depths. This paper presents the results of a study comparing the response spectra obtained from two of the more popular analysis methods for structural configurations varying from shallow embedment to complete embedment. A typical safety related structure embedded in a soil profile representative of a typical nuclear power plant site was utilized in the study and the depths of burial (DOB) considered range from 25-100% the height of the structure. Included in the paper are: (1) the description of a simplified analysis and a detailed approach for the SSI analyses of a structure with various DOB, (2) the comparison of the analysis results for the different DOBs between the two methods, and (3) the performance assessment of the analysis methodologies for SSI analyses of deeply embedded structures. The resulting assessment from this study has indicated that simplified methods may be capable of capturing the seismic response for much deeper embedded structures than would be normally allowed by the standard practice

Polarizable Density Embedding

DEFF Research Database (Denmark)

Reinholdt, Peter; Kongsted, Jacob; Olsen, Jógvan Magnus Haugaard

2017-01-01

We analyze the performance of the polarizable density embedding (PDE) model-a new multiscale computational approach designed for prediction and rationalization of general molecular properties of large and complex systems. We showcase how the PDE model very effectively handles the use of large...

Implementation of an embedded computer

OpenAIRE

Pikl, Bojan

2011-01-01

The goal of this thesis is to describe a production of an embedded computer. The thesis describes development and production of an embedded computer for the medical diode laser DL30 that is being developed in Robomed d.o.o.. The first part of the thesis describes the choice of hardware devices. I mostly describe the technologies that one can buy on the market. Moreover for every part of the computer installed and developed there is an argument why we selected that exact part. The second part ...

Quantum Thetas on Noncommutative T^d with General Embeddings

OpenAIRE

Chang-Young, Ee; Kim, Hoil

2007-01-01

In this paper we construct quantum theta functions over noncommutative T^d with general embeddings. Manin has constructed quantum theta functions from the lattice embedding into vector space x finite group. We extend Manin's construction of quantum thetas to the case of general embedding of vector space x lattice x torus. It turns out that only for the vector space part of the embedding there exists the holomorphic theta vector, while for the lattice part there does not. Furthermore, the so-c...

An embedded stress sensor for concrete SHM based on amorphous ferromagnetic microwires.

Science.gov (United States)

Olivera, Jesús; González, Margarita; Fuente, José Vicente; Varga, Rastislav; Zhukov, Arkady; Anaya, José Javier

2014-10-24

A new smart concrete aggregate design as a candidate for applications in structural health monitoring (SHM) of critical elements in civil infrastructure is proposed. The cement-based stress/strain sensor was developed by utilizing the stress/strain sensing properties of a magnetic microwire embedded in cement-based composite (MMCC). This is a contact-less type sensor that measures variations of magnetic properties resulting from stress variations. Sensors made of these materials can be designed to satisfy the specific demand for an economic way to monitor concrete infrastructure health. For this purpose, we embedded a thin magnetic microwire in the core of a cement-based cylinder, which was inserted into the concrete specimen under study as an extra aggregate. The experimental results show that the embedded MMCC sensor is capable of measuring internal compressive stress around the range of 1-30 MPa. Two stress sensing properties of the embedded sensor under uniaxial compression were studied: the peak amplitude and peak position of magnetic switching field. The sensitivity values for the amplitude and position within the measured range were 5 mV/MPa and 2.5 µs/MPa, respectively.

An Embedded Stress Sensor for Concrete SHM Based on Amorphous Ferromagnetic Microwires

Directory of Open Access Journals (Sweden)

Jesús Olivera

2014-10-01

Full Text Available A new smart concrete aggregate design as a candidate for applications in structural health monitoring (SHM of critical elements in civil infrastructure is proposed. The cement-based stress/strain sensor was developed by utilizing the stress/strain sensing properties of a magnetic microwire embedded in cement-based composite (MMCC. This is a contact-less type sensor that measures variations of magnetic properties resulting from stress variations. Sensors made of these materials can be designed to satisfy the specific demand for an economic way to monitor concrete infrastructure health. For this purpose, we embedded a thin magnetic microwire in the core of a cement-based cylinder, which was inserted into the concrete specimen under study as an extra aggregate. The experimental results show that the embedded MMCC sensor is capable of measuring internal compressive stress around the range of 1–30 MPa. Two stress sensing properties of the embedded sensor under uniaxial compression were studied: the peak amplitude and peak position of magnetic switching field. The sensitivity values for the amplitude and position within the measured range were 5 mV/MPa and 2.5 µs/MPa, respectively.

Experimental study on embedment effect of foundation, 2

International Nuclear Information System (INIS)

Ohtomo, Keizo; Toma, Junichi; Hashimoto, Koichi; Hanada, Kazutake; Ueshima, Teruyuki; Yajima, Hiroshi

1986-01-01

In order to make clear the dynamic behavior of a embeded foundation on the quarternary ground experimentally, a series of forced vibration tests and seismic observation on both the small foundation (4 x 4 x 3 m) and the embeded form larger scale foundation of the shaking table (16 x 16 x 7.7 m) were conducted at the same site. The purposes this study are evaluating the dynamic behavior and the characteristics of dynamic stiffness and damping of the larger foundation based on forced vibration tests, and applying them to the dynamic response analysis of variable embedded foundations. In this report, the authors first examine frequency dependent property and its theoretical tendency of dynamic stiffness and damping surrounding table foundation. And then, consider an applicability and point of discussion related with the some theories which influence the embedment effect, in contrast with the experimental datum of the model foundation are past studies on a embedment effect (JPDR, Large-Scale Foundation in Tadotsu). (author)

Programming Embedded Systems With C and GNU Development Tools

CERN Document Server

Barr, Michael

2009-01-01

Whether you're writing your first embedded program, designing the latest generation of hand-held whatchamacalits, or managing the people who do, this book is for you. Programming Embedded Systems will help you develop the knowledge and skills you need to achieve proficiency with embedded software.

Design and implement of pack filter module base on embedded firewall

Science.gov (United States)

Tian, Libo; Wang, Chen; Yang, Shunbo

2011-10-01

In the traditional security solution conditions, software firewall cannot intercept and respond the invasion before being attacked. And because of the high cost, the hardware firewall does not apply to the security strategy of the end nodes, so we have designed a kind of solution of embedded firewall with hardware and software. With ARM embedding Linux operating system, we have designed packet filter module and intrusion detection module to implement the basic function of firewall. Experiments and results show that that firewall has the advantages of low cost, high processing speed, high safety and the application of the computer terminals. This paper focuses on packet filtering module design and implementation.

Design of remote weather monitor system based on embedded web database

International Nuclear Information System (INIS)

Gao Jiugang; Zhuang Along

2010-01-01

The remote weather monitoring system is designed by employing the embedded Web database technology and the S3C2410 microprocessor as the core. The monitoring system can simultaneously monitor the multi-channel sensor signals, and can give a dynamic Web pages display of various types of meteorological information on the remote computer. It gives a elaborated introduction of the construction and application of the Web database under the embedded Linux. Test results show that the client access the Web page via the GPRS or the Internet, acquires data and uses an intuitive graphical way to display the value of various types of meteorological information. (authors)

Feasibility study on embedded transport core calculations

International Nuclear Information System (INIS)

Ivanov, B.; Zikatanov, L.; Ivanov, K.

2007-01-01

The main objective of this study is to develop an advanced core calculation methodology based on embedded diffusion and transport calculations. The scheme proposed in this work is based on embedded diffusion or SP 3 pin-by-pin local fuel assembly calculation within the framework of the Nodal Expansion Method (NEM) diffusion core calculation. The SP 3 method has gained popularity in the last 10 years as an advanced method for neutronics calculation. NEM is a multi-group nodal diffusion code developed, maintained and continuously improved at the Pennsylvania State University. The developed calculation scheme is a non-linear iteration process, which involves cross-section homogenization, on-line discontinuity factors generation, and boundary conditions evaluation by the global solution passed to the local calculation. In order to accomplish the local calculation, a new code has been developed based on the Finite Elements Method (FEM), which is capable of performing both diffusion and SP 3 calculations. The new code will be used in the framework of the NEM code in order to perform embedded pin-by-pin diffusion and SP 3 calculations on fuel assembly basis. The development of the diffusion and SP 3 FEM code is presented first following by its application to several problems. Description of the proposed embedded scheme is provided next as well as the obtained preliminary results of the C3 MOX benchmark. The results from the embedded calculations are compared with direct pin-by-pin whole core calculations in terms of accuracy and efficiency followed by conclusions made about the feasibility of the proposed embedded approach. (authors)

Unsteady Flame Embedding

KAUST Repository

El-Asrag, Hossam A.

2011-01-01

Direct simulation of all the length and time scales relevant to practical combustion processes is computationally prohibitive. When combustion processes are driven by reaction and transport phenomena occurring at the unresolved scales of a numerical simulation, one must introduce a dynamic subgrid model that accounts for the multiscale nature of the problem using information available on a resolvable grid. Here, we discuss a model that captures unsteady flow-flame interactions- including extinction, re-ignition, and history effects-via embedded simulations at the subgrid level. The model efficiently accounts for subgrid flame structure and incorporates detailed chemistry and transport, allowing more accurate prediction of the stretch effect and the heat release. In this chapter we first review the work done in the past thirty years to develop the flame embedding concept. Next we present a formulation for the same concept that is compatible with Large Eddy Simulation in the flamelet regimes. The unsteady flame embedding approach (UFE) treats the flame as an ensemble of locally one-dimensional flames, similar to the flamelet approach. However, a set of elemental one-dimensional flames is used to describe the turbulent flame structure directly at the subgrid level. The calculations employ a one-dimensional unsteady flame model that incorporates unsteady strain rate, curvature, and mixture boundary conditions imposed by the resolved scales. The model is used for closure of the subgrid terms in the context of large eddy simulation. Direct numerical simulation (DNS) data from a flame-vortex interaction problem is used for comparison. © Springer Science+Business Media B.V. 2011.

Biomolecule-embedded metal-organic frameworks as an innovative sensing platform.

Science.gov (United States)

Kempahanumakkagari, Sureshkumar; Kumar, Vanish; Samaddar, Pallabi; Kumar, Pawan; Ramakrishnappa, Thippeswamy; Kim, Ki-Hyun

Technological advancements combined with materials research have led to the generation of enormous types of novel substrates and materials for use in various biological/medical, energy, and environmental applications. Lately, the embedding of biomolecules in novel and/or advanced materials (e.g., metal-organic frameworks (MOFs), nanoparticles, hydrogels, graphene, and their hybrid composites) has become a vital research area in the construction of an innovative platform for various applications including sensors (or biosensors), biofuel cells, and bioelectronic devices. Due to the intriguing properties of MOFs (e.g., framework architecture, topology, and optical properties), they have contributed considerably to recent progresses in enzymatic catalysis, antibody-antigen interactions, or many other related approaches. Here, we aim to describe the different strategies for the design and synthesis of diverse biomolecule-embedded MOFs for various sensing (e.g., optical, electrochemical, biological, and miscellaneous) techniques. Additionally, the benefits and future prospective of MOFs-based biomolecular immobilization as an innovative sensing platform are discussed along with the evaluation on their performance to seek for further development in this emerging research area. Copyright © 2018. Published by Elsevier Inc.

In vitro and in vivo MMP gene expression localisation by In Situ-RT-PCR in cell culture and paraffin embedded human breast cancer cell line xenografts

International Nuclear Information System (INIS)

Haupt, Larisa M; Thompson, Erik W; Trezise, Ann EO; Irving, Rachel E; Irving, Michael G; Griffiths, Lyn R

2006-01-01

Members of the matrix metalloproteinase (MMP) family of proteases are required for the degradation of the basement membrane and extracellular matrix in both normal and pathological conditions. In vitro, MT1-MMP (MMP-14, membrane type-1-MMP) expression is higher in more invasive human breast cancer (HBC) cell lines, whilst in vivo its expression has been associated with the stroma surrounding breast tumours. MMP-1 (interstitial collagenase) has been associated with MDA-MB-231 invasion in vitro, while MMP-3 (stromelysin-1) has been localised around invasive cells of breast tumours in vivo. As MMPs are not stored intracellularly, the ability to localise their expression to their cells of origin is difficult. We utilised the unique in situ-reverse transcription-polymerase chain reaction (IS-RT-PCR) methodology to localise the in vitro and in vivo gene expression of MT1-MMP, MMP-1 and MMP-3 in human breast cancer. In vitro, MMP induction was examined in the MDA-MB-231 and MCF-7 HBC cell lines following exposure to Concanavalin A (Con A). In vivo, we examined their expression in archival paraffin embedded xenografts derived from a range of HBC cell lines of varied invasive and metastatic potential. Mouse xenografts are heterogenous, containing neoplastic human parenchyma with mouse stroma and vasculature and provide a reproducible in vivo model system correlated to the human disease state. In vitro, exposure to Con A increased MT1-MMP gene expression in MDA-MB-231 cells and decreased MT1-MMP gene expression in MCF-7 cells. MMP-1 and MMP-3 gene expression remained unchanged in both cell lines. In vivo, stromal cells recruited into each xenograft demonstrated differences in localised levels of MMP gene expression. Specifically, MDA-MB-231, MDA-MB-435 and Hs578T HBC cell lines are able to influence MMP gene expression in the surrounding stroma. We have demonstrated the applicability and sensitivity of IS-RT-PCR for the examination of MMP gene expression both in vitro and in

TTCN-3 for distributed testing embedded systems

NARCIS (Netherlands)

Blom, S.C.C.; Deiß, T.; Ioustinova, N.; Kontio, A.; Pol, van de J.C.; Rennoch, A.; Sidorova, N.; Virbitskaite, I.; Voronkov, A.

2007-01-01

Abstract. TTCN-3 is a standardized language for specifying and executing test suites that is particularly popular for testing embedded systems. Prior to testing embedded software in a target environment, the software is usually tested in the host environment. Executing in the host environment often

Improving emotion recognition systems by embedding cardiorespiratory coupling

International Nuclear Information System (INIS)

Valenza, Gaetano; Lanatá, Antonio; Scilingo, Enzo Pasquale

2013-01-01

This work aims at showing improved performances of an emotion recognition system embedding information gathered from cardiorespiratory (CR) coupling. Here, we propose a novel methodology able to robustly identify up to 25 regions of a two-dimensional space model, namely the well-known circumplex model of affect (CMA). The novelty of embedding CR coupling information in an autonomic nervous system-based feature space better reveals the sympathetic activations upon emotional stimuli. A CR synchrogram analysis was used to quantify such a coupling in terms of number of heartbeats per respiratory period. Physiological data were gathered from 35 healthy subjects emotionally elicited by means of affective pictures of the international affective picture system database. In this study, we finely detected five levels of arousal and five levels of valence as well as the neutral state, whose combinations were used for identifying 25 different affective states in the CMA plane. We show that the inclusion of the bivariate CR measures in a previously developed system based only on monovariate measures of heart rate variability, respiration dynamics and electrodermal response dramatically increases the recognition accuracy of a quadratic discriminant classifier, obtaining more than 90% of correct classification per class. Finally, we propose a comprehensive description of the CR coupling during sympathetic elicitation adapting an existing theoretical nonlinear model with external driving. The theoretical idea behind this model is that the CR system is comprised of weakly coupled self-sustained oscillators that, when exposed to an external perturbation (i.e. sympathetic activity), becomes synchronized and less sensible to input variations. Given the demonstrated role of the CR coupling, this model can constitute a general tool which is easily embedded in other model-based emotion recognition systems. (paper)

Advanced Technologies, Embedded and Multimedia for Human-Centric Computing

CERN Document Server

Chao, Han-Chieh; Deng, Der-Jiunn; Park, James; HumanCom and EMC 2013

2014-01-01

The theme of HumanCom and EMC are focused on the various aspects of human-centric computing for advances in computer science and its applications, embedded and multimedia computing and provides an opportunity for academic and industry professionals to discuss the latest issues and progress in the area of human-centric computing. And the theme of EMC (Advanced in Embedded and Multimedia Computing) is focused on the various aspects of embedded system, smart grid, cloud and multimedia computing, and it provides an opportunity for academic, industry professionals to discuss the latest issues and progress in the area of embedded and multimedia computing. Therefore this book will be include the various theories and practical applications in human-centric computing and embedded and multimedia computing.

Hard real-time multibody simulations using ARM-based embedded systems

Energy Technology Data Exchange (ETDEWEB)

Pastorino, Roland, E-mail: roland.pastorino@kuleuven.be, E-mail: rpastorino@udc.es; Cosco, Francesco, E-mail: francesco.cosco@kuleuven.be; Naets, Frank, E-mail: frank.naets@kuleuven.be; Desmet, Wim, E-mail: wim.desmet@kuleuven.be [KU Leuven, PMA division, Department of Mechanical Engineering (Belgium); Cuadrado, Javier, E-mail: javicuad@cdf.udc.es [Universidad de La Coruña, Laboratorio de Ingeniería Mecánica (Spain)

2016-05-15

The real-time simulation of multibody models on embedded systems is of particular interest for controllers and observers such as model predictive controllers and state observers, which rely on a dynamic model of the process and are customarily executed in electronic control units. This work first identifies the software techniques and tools required to easily write efficient code for multibody models to be simulated on ARM-based embedded systems. Automatic Programming and Source Code Translation are the two techniques that were chosen to generate source code for multibody models in different programming languages. Automatic Programming is used to generate procedural code in an intermediate representation from an object-oriented library and Source Code Translation is used to translate the intermediate representation automatically to an interpreted language or to a compiled language for efficiency purposes. An implementation of these techniques is proposed. It is based on a Python template engine and AST tree walkers for Source Code Generation and on a model-driven translator for the Source Code Translation. The code is translated from a metalanguage to any of the following four programming languages: Python-Numpy, Matlab, C++-Armadillo, C++-Eigen. Two examples of multibody models were simulated: a four-bar linkage with multiple loops and a 3D vehicle steering system. The code for these examples has been generated and executed on two ARM-based single-board computers. Using compiled languages, both models could be simulated faster than real-time despite the low resources and performance of these embedded systems. Finally, the real-time performance of both models was evaluated when executed in hard real-time on Xenomai for both embedded systems. This work shows through measurements that Automatic Programming and Source Code Translation are valuable techniques to develop real-time multibody models to be used in embedded observers and controllers.

Hard real-time multibody simulations using ARM-based embedded systems

International Nuclear Information System (INIS)

Pastorino, Roland; Cosco, Francesco; Naets, Frank; Desmet, Wim; Cuadrado, Javier

2016-01-01

The real-time simulation of multibody models on embedded systems is of particular interest for controllers and observers such as model predictive controllers and state observers, which rely on a dynamic model of the process and are customarily executed in electronic control units. This work first identifies the software techniques and tools required to easily write efficient code for multibody models to be simulated on ARM-based embedded systems. Automatic Programming and Source Code Translation are the two techniques that were chosen to generate source code for multibody models in different programming languages. Automatic Programming is used to generate procedural code in an intermediate representation from an object-oriented library and Source Code Translation is used to translate the intermediate representation automatically to an interpreted language or to a compiled language for efficiency purposes. An implementation of these techniques is proposed. It is based on a Python template engine and AST tree walkers for Source Code Generation and on a model-driven translator for the Source Code Translation. The code is translated from a metalanguage to any of the following four programming languages: Python-Numpy, Matlab, C++-Armadillo, C++-Eigen. Two examples of multibody models were simulated: a four-bar linkage with multiple loops and a 3D vehicle steering system. The code for these examples has been generated and executed on two ARM-based single-board computers. Using compiled languages, both models could be simulated faster than real-time despite the low resources and performance of these embedded systems. Finally, the real-time performance of both models was evaluated when executed in hard real-time on Xenomai for both embedded systems. This work shows through measurements that Automatic Programming and Source Code Translation are valuable techniques to develop real-time multibody models to be used in embedded observers and controllers.

Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue.

Science.gov (United States)

Carrascal, Mylène A; Talina, Catarina; Borralho, Paula; Gonçalo Mineiro, A; Henriques, Ana Raquel; Pen, Cláudia; Martins, Manuela; Braga, Sofia; Sackstein, Robert; Videira, Paula A

2018-05-02

The E-selectin ligands expressed by cancer cells mediate adhesion of circulating cancer cells to endothelial cells, as well as within tissue microenvironments important for tumor progression and metastasis. The identification of E-selectin ligands within cancer tissue could yield new biomarkers for patient stratification and aid in identifying novel therapeutic targets. The determinants of selectin ligands consist of sialylated tetrasaccharides, the sialyl Lewis X and A (sLe X and sLe A ), displayed on protein or lipid scaffolds. Standardized procedures for immunohistochemistry make use of the antibodies against sLe X and/or sLe A . However, antibody binding does not define E-selectin binding activity. In this study, we developed an immunohistochemical staining technique, using E-selectin-human Ig Fc chimera (E-Ig) to characterize the expression and localization of E-selectin binding sites on paraffin-embedded sections of different cancer tissue. E-Ig successfully stained cancer cells with high specificity. The E-Ig staining show high reactivity scores in colon and lung adenocarcinoma and moderate reactivity in triple negative breast cancer. Compared with reactivity of antibody against sLe X/A , the E-Ig staining presented higher specificity to cancer tissue with better defined borders and less background. The E-Ig staining technique allows the qualitative and semi-quantitative analysis of E-selectin binding activity on cancer cells. The development of accurate techniques for detection of selectin ligands may contribute to better diagnostic and better understanding of the molecular basis of tumor progression and metastasis.

Manipulating mammalian cell morphologies using chemical-mechanical polished integrated circuit chips

Science.gov (United States)

Moussa, Hassan I.; Logan, Megan; Siow, Geoffrey C.; Phann, Darron L.; Rao, Zheng; Aucoin, Marc G.; Tsui, Ting Y.

2017-12-01

Tungsten chemical-mechanical polished integrated circuits were used to study the alignment and immobilization of mammalian (Vero) cells. These devices consist of blanket silicon oxide thin films embedded with micro- and nano-meter scale tungsten metal line structures on the surface. The final surfaces are extremely flat and smooth across the entire substrate, with a roughness in the order of nanometers. Vero cells were deposited on the surface and allowed to adhere. Microscopy examinations revealed that cells have a strong preference to adhere to tungsten over silicon oxide surfaces with up to 99% of cells adhering to the tungsten portion of the surface. Cells self-aligned and elongated into long threads to maximize contact with isolated tungsten lines as thin as 180 nm. The orientation of the Vero cells showed sensitivity to the tungsten line geometric parameters, such as line width and spacing. Up to 93% of cells on 10 μm wide comb structures were aligned within ± 20° of the metal line axis. In contrast, only 22% of cells incubated on 0.18 μm comb patterned tungsten lines were oriented within the same angular interval. This phenomenon is explained using a simple model describing cellular geometry as a function of pattern width and spacing, which showed that cells will rearrange their morphology to maximize their contact to the embedded tungsten. Finally, it was discovered that the materials could be reused after cleaning the surfaces, while maintaining cell alignment capability.

Reliability Analysis and Optimal Release Problem Considering Maintenance Time of Software Components for an Embedded OSS Porting Phase

Science.gov (United States)

Tamura, Yoshinobu; Yamada, Shigeru

OSS (open source software) systems which serve as key components of critical infrastructures in our social life are still ever-expanding now. Especially, embedded OSS systems have been gaining a lot of attention in the embedded system area, i.e., Android, BusyBox, TRON, etc. However, the poor handling of quality problem and customer support prohibit the progress of embedded OSS. Also, it is difficult for developers to assess the reliability and portability of embedded OSS on a single-board computer. In this paper, we propose a method of software reliability assessment based on flexible hazard rates for the embedded OSS. Also, we analyze actual data of software failure-occurrence time-intervals to show numerical examples of software reliability assessment for the embedded OSS. Moreover, we compare the proposed hazard rate model for the embedded OSS with the typical conventional hazard rate models by using the comparison criteria of goodness-of-fit. Furthermore, we discuss the optimal software release problem for the porting-phase based on the total expected software maintenance cost.

Homogeneous Spaces and Equivariant Embeddings

CERN Document Server

Timashev, DA

2011-01-01

Homogeneous spaces of linear algebraic groups lie at the crossroads of algebraic geometry, theory of algebraic groups, classical projective and enumerative geometry, harmonic analysis, and representation theory. By standard reasons of algebraic geometry, in order to solve various problems on a homogeneous space it is natural and helpful to compactify it keeping track of the group action, i.e. to consider equivariant completions or, more generally, open embeddings of a given homogeneous space. Such equivariant embeddings are the subject of this book. We focus on classification of equivariant em

Certifiable Java for Embedded Systems

DEFF Research Database (Denmark)

Schoeberl, Martin; Dalsgaard, Andreas Engelbredt; Hansen, Rene Rydhof

2014-01-01

The Certifiable Java for Embedded Systems (CJ4ES) project aimed to develop a prototype development environment and platform for safety-critical software for embedded applications. There are three core constituents: A profile of the Java programming language that is tailored for safety......-critical applications, a predictable Java processor built with FPGA technology, and an Eclipse based application development environment that binds the profile and the platform together and provides analyses that help to provide evidence that can be used as part of a safety case. This paper summarizes key contributions...

Morphware - Fremtidens Embedded System Platform

DEFF Research Database (Denmark)

Madsen, Jan

2006-01-01

FPGA'er bliver i stigende grad brugt som komponenter i embedded systemer. Faldende priser, større kapacitet og en større felksibilitet har gjort FPGA'en til en attraktiv og konkurrencedygtig teknologi der tillader en stadig stigende grad af system integration, hvor traditionel hardware og software...... kombineres og rekonfigureres. Muligheden for at rekonfigurere systemet, og specielt rekonfigurerer det medens det kører, giver nogle helt nye muligheder for at designe og programmere embedded systemer. Dette foredrag vil give et indblik i disse nye og fremtidige muligheder....

Small Private Key PKS on an Embedded Microprocessor

OpenAIRE

Seo, Hwajeong; Kim, Jihyun; Choi, Jongseok; Park, Taehwan; Liu, Zhe; Kim, Howon

2014-01-01

Multivariate quadratic (MQ) cryptography requires the use of long public and private keys to ensure a sufficient security level, but this is not favorable to embedded systems, which have limited system resources. Recently, various approaches to MQ cryptography using reduced public keys have been studied. As a result of this, at CHES2011 (Cryptographic Hardware and Embedded Systems, 2011), a small public key MQ scheme, was proposed, and its feasible implementation on an embedded microprocessor...

A Resource-Aware Component Model for Embedded Systems

OpenAIRE

Vulgarakis, Aneta

2009-01-01

Embedded systems are microprocessor-based systems that cover a large range of computer systems from ultra small computer-based devices to large systems monitoring and controlling complex processes. The particular constraints that must be met by embedded systems, such as timeliness, resource-use efficiency, short time-to-market and low cost, coupled with the increasing complexity of embedded system software, demand technologies and processes that will tackle these issues. An attractive approac...

Human small-cell lung cancers show amplification and expression of the N-myc gene

International Nuclear Information System (INIS)

Nau, M.M.; Brooks, B.J. Jr.; Carney, D.N.; Gazdar, A.F.; Battey, J.F.; Sausville, E.A.; Minna, J.D.

1986-01-01

The authors have found that 6 of 31 independently derived human small-cell lung cancer (SCLC) cell lines have 5- to 170-fold amplified N-myc gene sequences. The amplification is seen with probes from two separate exons of N-myc, which are homologous to either the second or the third exon of the c-myc gene. Amplified N-myc sequences were found in a tumor cell line started prior to chemotherapy, in SCLC tumor samples harvested directly from tumor metastases at autopsy, and from a resected primary lung cancer. Several N-myc-amplified tumor cell lines also exhibited N-myc hybridizing fragments not in the germ-line position. In one patient's tumor, an additional amplitifed N-myc DNA fragment was observed and this fragment was heterogeneously distributed in liver metastases. In contrast to SCLC with neuroendocrine properties, no non-small-cell lung cancer lines examined were found to have N-myc amplification. Fragments encoding two N-myc exons also detect increased amounts of a 3.1-kilobase N-myc mRNA in N-myc-amplified SCLC lines and in one cell line that does not show N-myc gene amplification. Both DNA and RNA hybridization experiments, using a 32 P-labelled restriction probe, show that in any one SCLC cell line, only one myc-related gene is amplified and expressed. They conclude that N-myc amplification is both common and potentially significant in the tumorigenesis or tumor progression of SCLC

Multi-purpose passive debugging for embedded wireless

DEFF Research Database (Denmark)

Hansen, Morten Tranberg

Debugging embedded wireless systems can be cumbersome and hard due to low visibility. To ease the task of debugging we propose a multi-purpose passive debugging framework, called TinyDebug, for developing embedded wireless systems. TinyDebug is designed to be used throughout the entire system...

Patron perception and utilization of an embedded librarian program.

Science.gov (United States)

Blake, Lindsay; Ballance, Darra; Davies, Kathy; Gaines, Julie K; Mears, Kim; Shipman, Peter; Connolly-Brown, Maryska; Burchfield, Vicki

2016-07-01

The study measured the perceived value of an academic library's embedded librarian service model. The study took place at the health sciences campuses of a research institution. A web-based survey was distributed that asked respondents a series of questions about their utilization of and satisfaction with embedded librarians and services. Over 58% of respondents reported being aware of their embedded librarians, and 95% of these were satisfied with provided services. The overall satisfaction with services was encouraging, but awareness of the embedded program was low, suggesting an overall need for marketing of services.

PCB Embedded Inductor for High-Frequency ZVS SEPIC Converter

DEFF Research Database (Denmark)

Dou, Yi; Ouyang, Ziwei; Thummala, Prasanth

2018-01-01

The volume and temperature rise of passive components, especially inductors, limit the momentum toward high power density in high-frequency power converters. To address the limitations, PCB integration of passive components should be considered with the benefit of low profile, excellent thermal...... characteristic and cost reduction. This paper investigates an embedded structure of inductors to further increase the power density of a low power DC-DC converter. A pair of coupling inductors have been embedded into the PCB. The detailed embedded process has been described and the characteristics of embedded...

STFTP: Secure TFTP Protocol for Embedded Multi-Agent Systems Communication

Directory of Open Access Journals (Sweden)

ZAGAR, D.

2013-05-01

Full Text Available Today's embedded systems have evolved into multipurpose devices moving towards an embedded multi-agent system (MAS infrastructure. With the involvement of MAS in embedded systems, one remaining issues is establishing communication between agents in low computational power and low memory embedded systems without present Embedded Operating System (EOS. One solution is the extension of an outdated Trivial File Transfer Protocol (TFTP. The main advantage of using TFTP in embedded systems is the easy implementation. However, the problem at hand is the overall lack of security mechanisms in TFTP. This paper proposes an extension to the existing TFTP in a form of added security mechanisms: STFTP. The authentication is proposed using Digest Access Authentication process whereas the data encryption can be performed by various cryptographic algorithms. The proposal is experimentally tested using two embedded systems based on micro-controller architecture. Communication is analyzed for authentication, data rate and transfer time versus various data encryption ciphers and files sizes. STFTP results in an expected drop in performance, which is in the range of similar encryption algorithms. The system could be improved by using embedded systems of higher computational power or by the use of hardware encryption modules.

Experiences as an embedded librarian in online courses.

Science.gov (United States)

Konieczny, Alison

2010-01-01

Embedded librarianship gives librarians a prime opportunity to have a direct, positive impact in a clinical setting, classroom setting, or within a working group by providing integrated services that cater to the group's needs. Extending embedded librarian services beyond the various physical settings and into online classrooms is an exceptional way for librarians to engage online learners. This group of students is growing rapidly in numbers and could benefit greatly from having library services and resources incorporated into their classes. The author's services as an embedded librarian in fully online courses at a medium-sized university will be discussed, as will strategies, lessons learned, and opportunities for engaging in this realm. To develop a foundation of knowledge on embedded librarianship, an overview of this topic is provided.

Comparison of Video Steganography Methods for Watermark Embedding

Directory of Open Access Journals (Sweden)

Griberman David

2016-05-01

Full Text Available The paper focuses on the comparison of video steganography methods for the purpose of digital watermarking in the context of copyright protection. Four embedding methods that use Discrete Cosine and Discrete Wavelet Transforms have been researched and compared based on their embedding efficiency and fidelity. A video steganography program has been developed in the Java programming language with all of the researched methods implemented for experiments. The experiments used 3 video containers with different amounts of movement. The impact of the movement has been addressed in the paper as well as the ways of potential improvement of embedding efficiency using adaptive embedding based on the movement amount. Results of the research have been verified using a survey with 17 participants.

Electronic Cortisol Detection Using an Antibody-Embedded Polymer Coupled to a Field-Effect Transistor.

Science.gov (United States)

Jang, Hyun-June; Lee, Taein; Song, Jian; Russell, Luisa; Li, Hui; Dailey, Jennifer; Searson, Peter C; Katz, Howard E

2018-05-16

A field-effect transistor-based cortisol sensor was demonstrated in physiological conditions. An antibody-embedded polymer on the remote gate was proposed to overcome the Debye length issue (λ D ). The sensing membrane was made by linking poly(styrene- co-methacrylic acid) (PSMA) with anticortisol before coating the modified polymer on the remote gate. The embedded receptor in the polymer showed sensitivity from 10 fg/mL to 10 ng/mL for cortisol and a limit of detection (LOD) of 1 pg/mL in 1× PBS where λ D is 0.2 nm. A LOD of 1 ng/mL was shown in lightly buffered artificial sweat. Finally, a sandwich ELISA confirmed the antibody binding activity of antibody-embedded PSMA.

Earthquake response of nuclear reactor buildings deeply embedded in soil

International Nuclear Information System (INIS)

Masao, T.; Takasaki, Y.; Hirasawa, M.; Okajima, M.; Yamamoto, S.; Kawata, E.; Koori, Y.; Ochiai, S.; Shimizu, N.

1980-01-01

This paper is concerned with experimental and analytical studies to investigate dynamic behavior of deeply embedded structures such as nuclear reactor buildings. The principal points studied are as follows: (1) Examination of stiffness and radiation damping effects according to embedded depth, (2) verification for distributions of earth pressure according to embedded depth, (3) differences of response characteristics during oscillation according to embedded depth, and (4) proposal of an analytical method for seismic design. Experimental studies were performed by two ways: forced vibration test, and earthquake observation against a rigid body model embedded in soil. Three analytical procedures were performed to compare experimental results and to examine the relation between each procedure. Finally, the dynamic behavior for nuclear reactor buildings with different embedded depths were evaluated by an analytical method. (orig.)

Embedding in thermosetting resins

International Nuclear Information System (INIS)

Buzonniere, A. de

1985-01-01

Medium activity waste coming either from nuclear power plants in operation such as evaporator concentrates, spent resins, filter cartridges or the dismantling of installations are embedded in order to obtain a product suitable for long term disposal. Embedding in thermosetting resins (polyester or epoxy) is one among currently used techniques; it is being developed by the CEA (Commissariat a l'Energie Atomique) and Technicatome (subsidiary of CEA and EDF). The process is easy to operate and yields excellent results particularly as far as volume reduction and radioelement containment (cesium particularly) are concerned. The process has already been in operation in four stationary plants for several years. Extension of the process to mobile units has been completed by Technicatome in collaboration with the CEA [fr

Embedding of the radiation cosmos

International Nuclear Information System (INIS)

Wang, J.Z.

1986-01-01

The embedding of the Friedmann manifold into a higher dimensional Minkowski space is investigated. As solutions of the Friedmann equation with vanishing cosmological term, Friedmann models describe a first expanding, then contracting universe and predict a big bang singularity. For cosmic time t → 0, R(t) → 0, there is an infinite scalar, curvature in the matter cosmos, and an infinite eigenvalue corresponding to the unique timelike eigenvector of the energy-momentum tensor in the radiation cosmos. The big bang, therefore, is an intrinsic singularity of the space time. To investigate the singularity one resorts to the embedding of the Friedmann manifold into a higher dimensional Minkowski space. For the matter cosmos such an investigation has already been done (Lauro and Schucking, 1984). However, the matter cosmos is not a suitable model to discuss the very early universe where the radiation dominates. Geometric properties, such as the Riemann tensor, the Guassian curvature and the global behavior of the geodesics of the embedded manifold, are discussed in detail

Integrated Equivalent Circuit and Thermal Model for Simulation of Temperature-Dependent LiFePO4 Battery in Actual Embedded Application

Directory of Open Access Journals (Sweden)

Zuchang Gao

2017-01-01

Full Text Available A computational efficient battery pack model with thermal consideration is essential for simulation prototyping before real-time embedded implementation. The proposed model provides a coupled equivalent circuit and convective thermal model to determine the state-of-charge (SOC and temperature of the LiFePO4 battery working in a real environment. A cell balancing strategy applied to the proposed temperature-dependent battery model balanced the SOC of each cell to increase the lifespan of the battery. The simulation outputs are validated by a set of independent experimental data at a different temperature to ensure the model validity and reliability. The results show a root mean square (RMS error of 1.5609 × 10−5 for the terminal voltage and the comparison between the simulation and experiment at various temperatures (from 5 °C to 45 °C shows a maximum RMS error of 7.2078 × 10−5.

Embedded Java security security for mobile devices

CERN Document Server

Debbabi, Mourad; Talhi, Chamseddine

2007-01-01

Java brings more functionality and versatility to the world of mobile devices, but it also introduces new security threats. This book contains a presentation of embedded Java security and presents the main components of embedded Java. It gives an idea of the platform architecture and is useful for researchers and practitioners.

Structural, electronic and magnetic properties of transition-metal embedded zigzag-edged graphene nanoribbons

International Nuclear Information System (INIS)

Yu Guodong; Lü Xiaoling; Jiang Liwei; Gao Wenzhu; Zheng Yisong

2013-01-01

By means of ab initio calculations within density-functional theory, the structural, electronic and magnetic properties of a zigzag-edged graphene nanoribbon (ZGNR) with 3d transition-metal atoms (TMAs) (Sc–Zn) embedded in the periodically distributed single vacancies are systematically studied. Different from the pristine ZGNR, all of these composite structures show the subband structures with nontrivial spin polarizations, regardless of the type and the embedding position of the TMA. Embedding one kind of these atoms (V, Cr, Ni, Cu or Zn) near one ribbon edge can cause a notable edge distortion. Except for the cases of Sc, Fe and Co doping, other kinds of TMAs embedded near an edge of the ribbon can suppress the inherent magnetism of the zigzag edge. By further analysis, we find that two effects are responsible for the suppression of edge magnetism. One is the variation of the occupied spin-polarized subbands due to the hybridization of the edge state of the ZGNR and 3d atomic states of the dopant. The other is the delocalization of the edge state caused by the exotic TMA. The unilateral magnetism of these TMA-embedded ZGNRs can be utilized to realize the spin-polarized electronic transport, which is the key electronic property in the context of spintronics applications of carbon-based materials. (paper)

[Design of an embedded stroke rehabilitation apparatus system based on Linux computer engineering].

Science.gov (United States)

Zhuang, Pengfei; Tian, XueLong; Zhu, Lin

2014-04-01

A realizaton project of electrical stimulator aimed at motor dysfunction of stroke is proposed in this paper. Based on neurophysiological biofeedback, this system, using an ARM9 S3C2440 as the core processor, integrates collection and display of surface electromyography (sEMG) signal, as well as neuromuscular electrical stimulation (NMES) into one system. By embedding Linux system, the project is able to use Qt/Embedded as a graphical interface design tool to accomplish the design of stroke rehabilitation apparatus. Experiments showed that this system worked well.

Matrix regularization of embedded 4-manifolds

International Nuclear Information System (INIS)

Trzetrzelewski, Maciej

2012-01-01

We consider products of two 2-manifolds such as S 2 ×S 2 , embedded in Euclidean space and show that the corresponding 4-volume preserving diffeomorphism algebra can be approximated by a tensor product SU(N)⊗SU(N) i.e. functions on a manifold are approximated by the Kronecker product of two SU(N) matrices. A regularization of the 4-sphere is also performed by constructing N 2 ×N 2 matrix representations of the 4-algebra (and as a byproduct of the 3-algebra which makes the regularization of S 3 also possible).

Spatially Partitioned Embedded Runge--Kutta Methods

KAUST Repository

Ketcheson, David I.

2013-10-30

We study spatially partitioned embedded Runge--Kutta (SPERK) schemes for partial differential equations (PDEs), in which each of the component schemes is applied over a different part of the spatial domain. Such methods may be convenient for problems in which the smoothness of the solution or the magnitudes of the PDE coefficients vary strongly in space. We focus on embedded partitioned methods as they offer greater efficiency and avoid the order reduction that may occur in nonembedded schemes. We demonstrate that the lack of conservation in partitioned schemes can lead to nonphysical effects and propose conservative additive schemes based on partitioning the fluxes rather than the ordinary differential equations. A variety of SPERK schemes are presented, including an embedded pair suitable for the time evolution of fifth-order weighted nonoscillatory spatial discretizations. Numerical experiments are provided to support the theory.

Spatially Partitioned Embedded Runge--Kutta Methods

KAUST Repository

Ketcheson, David I.; MacDonald, Colin B.; Ruuth, Steven J.

2013-01-01

We study spatially partitioned embedded Runge--Kutta (SPERK) schemes for partial differential equations (PDEs), in which each of the component schemes is applied over a different part of the spatial domain. Such methods may be convenient for problems in which the smoothness of the solution or the magnitudes of the PDE coefficients vary strongly in space. We focus on embedded partitioned methods as they offer greater efficiency and avoid the order reduction that may occur in nonembedded schemes. We demonstrate that the lack of conservation in partitioned schemes can lead to nonphysical effects and propose conservative additive schemes based on partitioning the fluxes rather than the ordinary differential equations. A variety of SPERK schemes are presented, including an embedded pair suitable for the time evolution of fifth-order weighted nonoscillatory spatial discretizations. Numerical experiments are provided to support the theory.

Collagen gel droplet-embedded culture drug sensitivity test for adjuvant chemotherapy after complete resection of non-small-cell lung cancer.

Science.gov (United States)

Inoue, Masayoshi; Maeda, Hajime; Takeuchi, Yukiyasu; Fukuhara, Kenjiro; Shintani, Yasushi; Funakoshi, Yasunobu; Funaki, Soichiro; Nojiri, Takashi; Kusu, Takashi; Kusumoto, Hidenori; Kimura, Toru; Okumura, Meinoshin

2018-04-01

We conducted a prospective clinical study to individualize adjuvant chemotherapy after complete resection of non-small-cell lung cancer (NSCLC), based on the drug sensitivity test. Patients with resectable c-stage IB-IIIA NSCLC were registered between 2005 and 2010. We performed the collagen gel droplet-embedded culture drug sensitivity test (CD-DST) on a fresh surgical specimen to assess in vitro chemosensitivity and evaluated the prognostic outcome after adjuvant chemotherapy with carboplatin/paclitaxel based on the CD-DST. Among 92 registered patients, 87 were eligible for inclusion in the analysis. The success rate of CD-DST was 86% and chemosensitivity to carboplatin and/or paclitaxel was evident in 57 (76%) of the 75 patients. Adjuvant chemotherapy was completed in 22 (73%) of 30 patients. The 5-year overall survival rates were 71, 73, and 75% for all, CD-DST success, and chemosensitive patients, respectively. The 5-year disease-free survival and overall survival rates of the chemosensitive patients who completed adjuvant chemotherapy using carboplatin/paclitaxel were 68 and 82%, respectively. The 5-year disease-free survival and overall survival rates of the patients with stage II-IIIA chemosensitive NSCLC were 58 and 75%, respectively. Comparative analyses of the chemosensitive and non-chemosensitive/CD-DST failure groups showed no significant survival difference. CD-DST can be used to evaluate chemosensitivity after lung cancer surgery; however, its clinical efficacy for assessing individualized treatment remains uncertain.

Patron perception and utilization of an embedded librarian program

Directory of Open Access Journals (Sweden)

Lindsay Blake, MLIS, AHIP

2016-09-01

Full Text Available Objective: The study measured the perceived value of an academic library’s embedded librarian service model. Setting: The study took place at the health sciences campuses of a research institution. Methods: A web-based survey was distributed that asked respondents a series of questions about their utilization of and satisfaction with embedded librarians and services. Results: Over 58% of respondents reported being aware of their embedded librarians, and 95% of these were satisfied with provided services. Conclusions: The overall satisfaction with services was encouraging, but awareness of the embedded program was low, suggesting an overall need for marketing of services.

Starvation-Survival in Haloarchaea.

Science.gov (United States)

Winters, Yaicha D; Lowenstein, Tim K; Timofeeff, Michael N

2015-11-12

Recent studies claiming to revive ancient microorganisms trapped in fluid inclusions in halite have warranted an investigation of long-term microbial persistence. While starvation-survival is widely reported for bacteria, it is less well known for halophilic archaea-microorganisms likely to be trapped in ancient salt crystals. To better understand microbial survival in fluid inclusions in ancient evaporites, laboratory experiments were designed to simulate growth of halophilic archaea under media-rich conditions, complete nutrient deprivation, and a controlled substrate condition (glycerol-rich) and record their responses. Haloarchaea used for this work included Hbt. salinarum and isolate DV582A-1 (genus Haloterrigena) sub-cultured from 34 kyear Death Valley salt. Hbt. salinarum and DV582A-1 reacted to nutrient limitation with morphological and population changes. Starved populations increased and most cells converted from rods to small cocci within 56 days of nutrient deprivation. The exact timing of starvation adaptations and the physical transformations differed between species, populations of the same species, and cells of the same population. This is the first study to report the timing of starvation strategies for Hbt. salinarum and DV582A-1. The morphological states in these experiments may allow differentiation between cells trapped with adequate nutrients (represented here by early stages in nutrient-rich media) from cells trapped without nutrients (represented here by experimental starvation) in ancient salt. The hypothesis that glycerol, leaked from Dunaliella, provides nutrients for the survival of haloarchaea trapped in fluid inclusions in ancient halite, is also tested. Hbt. salinarum and DV582A-1 were exposed to a mixture of lysed and intact Dunaliella for 56 days. The ability of these organisms to utilize glycerol from Dunaliella cells was assessed by documenting population growth, cell length, and cell morphology. Hbt. salinarum and DV582A-1

Starvation-Survival in Haloarchaea

Directory of Open Access Journals (Sweden)

Yaicha D. Winters

2015-11-01

Full Text Available Recent studies claiming to revive ancient microorganisms trapped in fluid inclusions in halite have warranted an investigation of long-term microbial persistence. While starvation-survival is widely reported for bacteria, it is less well known for halophilic archaea—microorganisms likely to be trapped in ancient salt crystals. To better understand microbial survival in fluid inclusions in ancient evaporites, laboratory experiments were designed to simulate growth of halophilic archaea under media-rich conditions, complete nutrient deprivation, and a controlled substrate condition (glycerol-rich and record their responses. Haloarchaea used for this work included Hbt. salinarum and isolate DV582A-1 (genus Haloterrigena sub-cultured from 34 kyear Death Valley salt. Hbt. salinarum and DV582A-1 reacted to nutrient limitation with morphological and population changes. Starved populations increased and most cells converted from rods to small cocci within 56 days of nutrient deprivation. The exact timing of starvation adaptations and the physical transformations differed between species, populations of the same species, and cells of the same population. This is the first study to report the timing of starvation strategies for Hbt. salinarum and DV582A-1. The morphological states in these experiments may allow differentiation between cells trapped with adequate nutrients (represented here by early stages in nutrient-rich media from cells trapped without nutrients (represented here by experimental starvation in ancient salt. The hypothesis that glycerol, leaked from Dunaliella, provides nutrients for the survival of haloarchaea trapped in fluid inclusions in ancient halite, is also tested. Hbt. salinarum and DV582A-1 were exposed to a mixture of lysed and intact Dunaliella for 56 days. The ability of these organisms to utilize glycerol from Dunaliella cells was assessed by documenting population growth, cell length, and cell morphology. Hbt. salinarum

Six transformer based asymmetrical embedded Z-source inverters

DEFF Research Database (Denmark)

Wei, Mo; Poh Chiang, Loh; Chi, Jin

2013-01-01

Embedded/Asymmetrical embedded Z-source inverters were proposed to maintain smooth input current/voltage across the dc source and within the impedance network, remain the shoot-through feature used to boost up the dc-link voltage without adding bulky filter at input side. This paper introduces a ...... a class of transformer based asymmetrical embedded Z-source inverters which keep the smooth input current and voltage while achieving enhanced voltage boost capability. The presented inverters are verified by laboratory prototypes experimentally....

Dominant ultraviolet-blue photoluminescence of ZnO embedded into synthetic opal

International Nuclear Information System (INIS)

Abrarov, S.M.; Yuldashev, Sh.U.; Kim, T.W.; Lee, S.B.; Kwon, H.Y.; Kang, T.W.

2005-01-01

The temperature-dependent photoluminescence (PL) characteristics of zinc oxide (ZnO) embedded into the voids of synthetic opal were studied. ZnO was infiltrated into opal from aqueous solution with zinc nitrate precursor followed by thermal annealing. The PL spectra of the ZnO powder exhibit very high and broad emission peaks in the green region due to crystal defects, such as oxygen vacancies and zinc ion interstitials. In contrast to the PL spectra of ZnO powder, nanocrystals of ZnO embedded into the voids of FCC packed opal matrix exhibit dominant ultraviolet (UV)-blue and rapidly decreasing green PL emissions with decreasing temperature. The temperature-dependent PL characteristics show that the green band suppression in the ZnO nanocrystals is due to the influence of photonic crystal. The infiltration of nanoparticles into synthetic opal may be used for the fabrication of polycrystalline ZnO with dominant UV-blue PL. These results indicate that the luminescent materials embedded into photonic crystal may be promising for the fabrication of the RGB pixels in full-color displays

Embedding Dimension Selection for Adaptive Singular Spectrum Analysis of EEG Signal.

Science.gov (United States)

Xu, Shanzhi; Hu, Hai; Ji, Linhong; Wang, Peng

2018-02-26

The recorded electroencephalography (EEG) signal is often contaminated with different kinds of artifacts and noise. Singular spectrum analysis (SSA) is a powerful tool for extracting the brain rhythm from a noisy EEG signal. By analyzing the frequency characteristics of the reconstructed component (RC) and the change rate in the trace of the Toeplitz matrix, it is demonstrated that the embedding dimension is related to the frequency bandwidth of each reconstructed component, in consistence with the component mixing in the singular value decomposition step. A method for selecting the embedding dimension is thereby proposed and verified by simulated EEG signal based on the Markov Process Amplitude (MPA) EEG Model. Real EEG signal is also collected from the experimental subjects under both eyes-open and eyes-closed conditions. The experimental results show that based on the embedding dimension selection method, the alpha rhythm can be extracted from the real EEG signal by the adaptive SSA, which can be effectively utilized to distinguish between the eyes-open and eyes-closed states.

A real-time spike sorting method based on the embedded GPU.

Science.gov (United States)

Zelan Yang; Kedi Xu; Xiang Tian; Shaomin Zhang; Xiaoxiang Zheng

2017-07-01

Microelectrode arrays with hundreds of channels have been widely used to acquire neuron population signals in neuroscience studies. Online spike sorting is becoming one of the most important challenges for high-throughput neural signal acquisition systems. Graphic processing unit (GPU) with high parallel computing capability might provide an alternative solution for increasing real-time computational demands on spike sorting. This study reported a method of real-time spike sorting through computing unified device architecture (CUDA) which was implemented on an embedded GPU (NVIDIA JETSON Tegra K1, TK1). The sorting approach is based on the principal component analysis (PCA) and K-means. By analyzing the parallelism of each process, the method was further optimized in the thread memory model of GPU. Our results showed that the GPU-based classifier on TK1 is 37.92 times faster than the MATLAB-based classifier on PC while their accuracies were the same with each other. The high-performance computing features of embedded GPU demonstrated in our studies suggested that the embedded GPU provide a promising platform for the real-time neural signal processing.

Embedding Dimension Selection for Adaptive Singular Spectrum Analysis of EEG Signal

Directory of Open Access Journals (Sweden)

Shanzhi Xu

2018-02-01

Full Text Available The recorded electroencephalography (EEG signal is often contaminated with different kinds of artifacts and noise. Singular spectrum analysis (SSA is a powerful tool for extracting the brain rhythm from a noisy EEG signal. By analyzing the frequency characteristics of the reconstructed component (RC and the change rate in the trace of the Toeplitz matrix, it is demonstrated that the embedding dimension is related to the frequency bandwidth of each reconstructed component, in consistence with the component mixing in the singular value decomposition step. A method for selecting the embedding dimension is thereby proposed and verified by simulated EEG signal based on the Markov Process Amplitude (MPA EEG Model. Real EEG signal is also collected from the experimental subjects under both eyes-open and eyes-closed conditions. The experimental results show that based on the embedding dimension selection method, the alpha rhythm can be extracted from the real EEG signal by the adaptive SSA, which can be effectively utilized to distinguish between the eyes-open and eyes-closed states.

Efficient and Secure Fingerprint Verification for Embedded Devices

Directory of Open Access Journals (Sweden)

Sakiyama Kazuo

2006-01-01

Full Text Available This paper describes a secure and memory-efficient embedded fingerprint verification system. It shows how a fingerprint verification module originally developed to run on a workstation can be transformed and optimized in a systematic way to run real-time on an embedded device with limited memory and computation power. A complete fingerprint recognition module is a complex application that requires in the order of 1000 M unoptimized floating-point instruction cycles. The goal is to run both the minutiae extraction and the matching engines on a small embedded processor, in our case a 50 MHz LEON-2 softcore. It does require optimization and acceleration techniques at each design step. In order to speed up the fingerprint signal processing phase, we propose acceleration techniques at the algorithm level, at the software level to reduce the execution cycle number, and at the hardware level to distribute the system work load. Thirdly, a memory trace map-based memory reduction strategy is used for lowering the system memory requirement. Lastly, at the hardware level, it requires the development of specialized coprocessors. As results of these optimizations, we achieve a 65% reduction on the execution time and a 67% reduction on the memory storage requirement for the minutiae extraction process, compared against the reference implementation. The complete operation, that is, fingerprint capture, feature extraction, and matching, can be done in real-time of less than 4 seconds

Electrolyte transport in neutral polymer gels embedded with charged inclusions

Science.gov (United States)

Hill, Reghan

2005-11-01

Ion permeable membranes are the basis of a variety of molecular separation technologies, including ion exchange, gel electrophoresis and dialysis. This work presents a theoretical model of electrolyte transport in membranes comprised of a continuous polymer gel embedded with charged spherical inclusions, e.g., biological cells and synthetic colloids. The microstructure mimics immobilized cell cultures, where electric fields have been used to promote nutrient transport. Because several important characteristics can, in principle, be carefully controlled, the theory provides a quantitative framework to help tailor the bulk properties for enhanced molecular transport, microfluidic pumping, and physicochemical sensing applications. This talk focuses on the electroosmotic flow driven by weak electric fields and electrolyte concentration gradients. Also of importance is the influence of charge on the effective ion diffusion coefficients, bulk electrical conductivity, and membrane diffusion potential.

Making the Case for Embedded Metadata in Digital Images

DEFF Research Database (Denmark)

Smith, Kari R.; Saunders, Sarah; Kejser, U.B.

2014-01-01

This paper discusses the standards, methods, use cases, and opportunities for using embedded metadata in digital images. In this paper we explain the past and current work engaged with developing specifications, standards for embedding metadata of different types, and the practicalities of data...... exchange in heritage institutions and the culture sector. Our examples and findings support the case for embedded metadata in digital images and the opportunities for such use more broadly in non-heritage sectors as well. We encourage the adoption of embedded metadata by digital image content creators...... and curators as well as those developing software and hardware that support the creation or re-use of digital images. We conclude that the usability of born digital images as well as physical objects that are digitized can be extended and the files preserved more readily with embedded metadata....

Making the Case for Embedded Metadata in Digital Images

DEFF Research Database (Denmark)

Smith, Kari R.; Saunders, Sarah; Kejser, U.B.

2014-01-01

exchange in heritage institutions and the culture sector. Our examples and findings support the case for embedded metadata in digital images and the opportunities for such use more broadly in non-heritage sectors as well. We encourage the adoption of embedded metadata by digital image content creators......This paper discusses the standards, methods, use cases, and opportunities for using embedded metadata in digital images. In this paper we explain the past and current work engaged with developing specifications, standards for embedding metadata of different types, and the practicalities of data...... and curators as well as those developing software and hardware that support the creation or re-use of digital images. We conclude that the usability of born digital images as well as physical objects that are digitized can be extended and the files preserved more readily with embedded metadata....

Embedded system based on PWM control of hydrogen generator with SEPIC converter

Science.gov (United States)

Fall, Cheikh; Setiawan, Eko; Habibi, Muhammad Afnan; Hodaka, Ichijo

2017-09-01

The objective of this paper is to design and to produce a micro electrical plant system based on fuel cell for teaching material-embedded systems in technical vocational training center. Based on this, the student can experience generating hydrogen by fuel cells, controlling the rate of hydrogen generation by the duty ration of single-ended primary-inductor converter(SEPIC), drawing the curve rate of hydrogen to duty ratio, generating electrical power by using hydrogen, and calculating the fuel cell efficiency when it is used as electrical energy generator. This project is of great importance insofar as students will need to acquire several skills to be able to realize it such as continuous DC DC conversion and the scientific concept behind the converter, the regulation of systems with integral proportional controllers, the installation of photovoltaic cells, the use of high-tech sensors, microcontroller programming, object-oriented programming, mastery of the fuel cell syste

Operating system concepts for embedded multicores

OpenAIRE

Horst, Oliver; Schmidt, Adriaan

2014-01-01

Currently we can see an increasing adoption of multi-core platforms in the area of embedded systems. While these new hardware platforms offer the potential to satisfy the ever increasing demand for computational power, they pose considerable challenges with regard to software development. This affects the application software itself, but also the system design and architecture. Here, we address the consequences for operating system architecture in embedded systems. After dis-cussing current a...

Embedded Fragments Registry (EFR)

Data.gov (United States)

Department of Veterans Affairs — In 2009, the Department of Defense estimated that approximately 40,000 service members who served in OEF/OIF may have embedded fragment wounds as the result of small...

Immunolocalization of progesterone receptors in binucleate trophoblast cells of the buffalo placenta (Bubalus bubalis

Directory of Open Access Journals (Sweden)

Carlos Eduardo Ambrósio

2007-06-01

Full Text Available The binucleate trophoblast cells (CTBs of the water buffalo placenta (Bubalus bubalis were studied with emphasis on the presence of progesterone receptor. Placentomal tissues from 27 buffalos (2-10 months of pregnancy were processed and embedded in paraplast (Paraplast Embedding Media – Paraplast Plus to locate the progesterone receptors using the immunohistochemistry technique. The immunohistochemical reaction for progesterone receptor through monoclonal antibody PgR Ab2 showed staining of CTBs, caruncular epithelial and estromal cells and blood vessel estromal pericitos present in the placentome throughout the entire gestational period analyzed. These results indicate the production of progesterone with autocrine and paracrine action in the placentome growth, differentiation and functional regulation.

Wireless and embedded carbon nanotube networks for damage detection in concrete structures

International Nuclear Information System (INIS)

Saafi, Mohamed

2009-01-01

Concrete structures undergo an uncontrollable damage process manifesting in the form of cracks due to the coupling of fatigue loading and environmental effects. In order to achieve long-term durability and performance, continuous health monitoring systems are needed to make critical decisions regarding operation, maintenance and repairs. Recent advances in nanostructured materials such as carbon nanotubes have opened the door for new smart and advanced sensing materials that could effectively be used in health monitoring of structures where wireless and real time sensing could provide information on damage development. In this paper, carbon nanotube networks were embedded into a cement matrix to develop an in situ wireless and embedded sensor for damage detection in concrete structures. By wirelessly measuring the change in the electrical resistance of the carbon nanotube networks, the progress of damage can be detected and monitored. As a proof of concept, wireless cement-carbon nanotube sensors were embedded into concrete beams and subjected to monotonic and cyclic loading to evaluate the effect of damage on their response. Experimental results showed that the wireless response of the embedded nanotube sensors changes due to the formation of cracks during loading. In addition, the nanotube sensors were able to detect the initiation of damage at an early stage of loading.

Wireless and embedded carbon nanotube networks for damage detection in concrete structures

Science.gov (United States)

Saafi, Mohamed

2009-09-01

Concrete structures undergo an uncontrollable damage process manifesting in the form of cracks due to the coupling of fatigue loading and environmental effects. In order to achieve long-term durability and performance, continuous health monitoring systems are needed to make critical decisions regarding operation, maintenance and repairs. Recent advances in nanostructured materials such as carbon nanotubes have opened the door for new smart and advanced sensing materials that could effectively be used in health monitoring of structures where wireless and real time sensing could provide information on damage development. In this paper, carbon nanotube networks were embedded into a cement matrix to develop an in situ wireless and embedded sensor for damage detection in concrete structures. By wirelessly measuring the change in the electrical resistance of the carbon nanotube networks, the progress of damage can be detected and monitored. As a proof of concept, wireless cement-carbon nanotube sensors were embedded into concrete beams and subjected to monotonic and cyclic loading to evaluate the effect of damage on their response. Experimental results showed that the wireless response of the embedded nanotube sensors changes due to the formation of cracks during loading. In addition, the nanotube sensors were able to detect the initiation of damage at an early stage of loading.

RESLanjut: The learning media for improve students understanding in embedded systems

Science.gov (United States)

Indrianto, Susanti, Meilia Nur Indah; Karina, Djunaidi

2017-08-01

The use of network in embedded system can be done with many kinds of network, with the use of mobile phones, bluetooths, modems, ethernet cards, wireless technology and so on. Using network in embedded system could help people to do remote controlling. On previous research, researchers found that many students have the ability to comprehend the basic concept of embedded system. They could also make embedded system tools but without network integration. And for that, a development is needed for the embedded system module. The embedded system practicum module design needs a prototype method in order to achieve the desired goal. The prototype method is often used in the real world. Or even, a prototype method is a part of products that consist of logic expression or external physical interface. The embedded system practicum module is meant to increase student comprehension of embedded system course, and also to encourage students to innovate on technology based tools. It is also meant to help teachers to teach the embedded system concept on the course. The student comprehension is hoped to increase with the use of practicum course.

Rapid Open Source GPS software development for modern embedded systems:using the GPSTk with the Gumstix

OpenAIRE

Salazar Hernández, Dagoberto José; Hernández Pajares, Manuel; Juan Zornoza, José Miguel; Sanz Subirana, Jaume

2006-01-01

This work shows how the combination of GPS Open Source Software (GOSS) and advanced full function miniature computers (FFMC) allows rapid development, implementation and testing of advanced embedded GNSS data processing applications in a flexible way. In this regard, our tools of choice are the “GPS Toolkit” (GPSTk), and a modern, high power embedded platform such as the “Gumstix” computer boards. Peer Reviewed

Embedding the Finite Sampling Process at a Rate

OpenAIRE

Shorack, Galen R.

1991-01-01

A huge body of if and only if theorems can be obtained based on certain strong embedding theorems for the partial sum process $\\mathbb{S}_n$ and the uniform empirical and quantile processes $\\mathbb{U}_n$ and $\\mathbb{V}_n$. This embedding was accomplished in 1986 by M. Csorgo, S. Csorgo, L. Horvath and D. Mason. Their embedding is beautifully formulated so that many necessary and sufficient type results can be established using it. It is worthwhile to have an accessible proof. Indeed, these ...

Making embedded systems design patterns for great software

CERN Document Server

White, Elecia

2011-01-01

Interested in developing embedded systems? Since they don't tolerate inefficiency, these systems require a disciplined approach to programming. This easy-to-read guide helps you cultivate a host of good development practices, based on classic software design patterns and new patterns unique to embedded programming. Learn how to build system architecture for processors, not operating systems, and discover specific techniques for dealing with hardware difficulties and manufacturing requirements. Written by an expert who's created embedded systems ranging from urban surveillance and DNA scanner

The Hidden Flow Structure and Metric Space of Network Embedding Algorithms Based on Random Walks.

Science.gov (United States)

Gu, Weiwei; Gong, Li; Lou, Xiaodan; Zhang, Jiang

2017-10-13

Network embedding which encodes all vertices in a network as a set of numerical vectors in accordance with it's local and global structures, has drawn widespread attention. Network embedding not only learns significant features of a network, such as the clustering and linking prediction but also learns the latent vector representation of the nodes which provides theoretical support for a variety of applications, such as visualization, link prediction, node classification, and recommendation. As the latest progress of the research, several algorithms based on random walks have been devised. Although those algorithms have drawn much attention for their high scores in learning efficiency and accuracy, there is still a lack of theoretical explanation, and the transparency of those algorithms has been doubted. Here, we propose an approach based on the open-flow network model to reveal the underlying flow structure and its hidden metric space of different random walk strategies on networks. We show that the essence of embedding based on random walks is the latent metric structure defined on the open-flow network. This not only deepens our understanding of random- walk-based embedding algorithms but also helps in finding new potential applications in network embedding.

A Self-embedding Robust Digital Watermarking Algorithm with Blind Detection

Directory of Open Access Journals (Sweden)

Gong Yunfeng

2014-08-01

Full Text Available In order to achieve the perfectly blind detection of robustness watermarking algorithm, a novel self-embedding robust digital watermarking algorithm with blind detection is proposed in this paper. Firstly the original image is divided to not overlap image blocks and then decomposable coefficients are obtained by lifting-based wavelet transform in every image blocks. Secondly the low-frequency coefficients of block images are selected and then approximately represented as a product of a base matrix and a coefficient matrix using NMF. Then the feature vector represent original image is obtained by quantizing coefficient matrix, and finally the adaptive quantization of the robustness watermark is embedded in the low-frequency coefficients of LWT. Experimental results show that the scheme is robust against common signal processing attacks, meanwhile perfect blind detection is achieve.

Preservation of protein fluorescence in embedded human dendritic cells for targeted 3D light and electron microscopy.

Science.gov (United States)

Höhn, K; Fuchs, J; Fröber, A; Kirmse, R; Glass, B; Anders-Össwein, M; Walther, P; Kräusslich, H-G; Dietrich, C

2015-08-01

In this study, we present a correlative microscopy workflow to combine detailed 3D fluorescence light microscopy data with ultrastructural information gained by 3D focused ion beam assisted scanning electron microscopy. The workflow is based on an optimized high pressure freezing/freeze substitution protocol that preserves good ultrastructural detail along with retaining the fluorescence signal in the resin embedded specimens. Consequently, cellular structures of interest can readily be identified and imaged by state of the art 3D confocal fluorescence microscopy and are precisely referenced with respect to an imprinted coordinate system on the surface of the resin block. This allows precise guidance of the focused ion beam assisted scanning electron microscopy and limits the volume to be imaged to the structure of interest. This, in turn, minimizes the total acquisition time necessary to conduct the time consuming ultrastructural scanning electron microscope imaging while eliminating the risk to miss parts of the target structure. We illustrate the value of this workflow for targeting virus compartments, which are formed in HIV-pulsed mature human dendritic cells. © 2015 The Authors Journal of Microscopy © 2015 Royal Microscopical Society.

Mechanical and Vibration Testing of Carbon Fiber Composite Material with Embedded Piezoelectric Sensors

Science.gov (United States)

Duffy, Kirsten P.; Lerch, Bradley A.; Wilmoth, Nathan G.; Kray, Nicholas; Gemeinhardt, Gregory

2012-01-01

Piezoelectric materials have been proposed as a means of decreasing turbomachinery blade vibration either through a passive damping scheme, or as part of an active vibration control system. For polymer matrix fiber composite (PMFC) blades, the piezoelectric elements could be embedded within the blade material, protecting the brittle piezoceramic material from the airflow and from debris. Before implementation of a piezoelectric element within a PMFC blade, the effect on PMFC mechanical properties needs to be understood. This study attempts to determine how the inclusion of a packaged piezoelectric patch affects the material properties of the PMFC. Composite specimens with embedded piezoelectric patches were tested in four-point bending, short beam shear, and flatwise tension configurations. Results show that the embedded piezoelectric material does decrease the strength of the composite material, especially in flatwise tension, attributable to failure at the interface or within the piezoelectric element itself. In addition, the sensing properties of the post-cured embedded piezoelectric materials were tested, and performed as expected. The piezoelectric materials include a non-flexible patch incorporating solid piezoceramic material, and two flexible patch types incorporating piezoelectric fibers. The piezoceramic material used in these patches was Navy Type-II PZT.

Is embedding entailed in consumer valuation of food safety characteristics?

DEFF Research Database (Denmark)

Mørkbak, Morten Raun; Christensen, Tove; Gyrd-Hansen, Dorte

2011-01-01

Consumers' preferences for food safety characteristics are investigated with a particular focus on the existence of an embedding effect. Embedding exists if consumer valuation of food safety is insensitive to scope. We conduct between-attribute external tests for embedding in two choice experiments...

Embedded fiber optic ultrasonic sensors and generators

Science.gov (United States)

Dorighi, John F.; Krishnaswamy, Sridhar; Achenbach, Jan D.

1995-04-01

Ultrasonic sensors and generators based on fiber-optic systems are described. It is shown that intrinsic fiber optic Fabry-Perot ultrasound sensors that are embedded in a structure can be stabilized by actively tuning the laser frequency. The need for this method of stabilization is demonstrated by detecting piezoelectric transducer-generated ultrasonic pulses in the presence of low frequency dynamic strains that are intentionally induced to cause sensor drift. The actively stabilized embedded fiber optic Fabry-Perot sensor is also shown to have sufficient sensitivity to detect ultrasound that is generated in the interior of a structure by means of a high-power optical fiber that pipes energy from a pulsed laser to an embedded generator of ultrasound.

Eulerian graph embeddings and trails confined to lattice tubes

International Nuclear Information System (INIS)

Soteros, C E

2006-01-01

Embeddings of graphs in sublattices of the square and simple cubic lattice known as tubes (or prisms) are considered. For such sublattices, two combinatorial bounds are obtained which each relate the number of embeddings of all closed eulerian graphs with k branch points (vertices of degree greater than two) to the number of self-avoiding polygons. From these bounds it is proved that the entropic critical exponent for the number of embeddings of closed eulerian graphs with k branch points is equal to k, and the entropic critical exponent for the number of closed trails with k branch points is equal to k + 1. One of the required combinatorial bounds is obtained via Madras' 1999 lattice cluster pattern theorem, which yields a bound on the number of ways to convert a self-avoiding polygon into a closed eulerian graph embedding with k branch points. The other combinatorial bound is established by constructing a method for sequentially removing branch points from a closed eulerian graph embedding; this yields a bound on the number of ways to convert a closed eulerian graph embedding into a self-avoiding polygon

Property A and Coarse Embedding for Locally Compact Groups

DEFF Research Database (Denmark)

Li, Kang

property A. In a joint work with Knudby, we characterize the connected simple Lie groups with the discrete topology that have different approximation properties (see Article B). Moreover, we give a contractive Schur multiplier characterization of locally compact groups coarsely embeddable into Hilbert......In the study of the Novikov conjecture, property A and coarse embedding of metric spaces were introduced by Yu and Gromov, respectively. The main topic of the thesis is property A and coarse embedding for locally compact second countable groups. We prove that many of the results that are known...... to hold in the discrete setting, hold also in the locally compact setting.In a joint work with Deprez, we show that property A is equivalent to amenability at infinity and the strong Novikov conjecture is true for every locally compact group that embeds coarsely into a Hilbert space (see Article A...