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Sample records for haimes michael whong-barr

  1. Haim-Munk syndrome

    Directory of Open Access Journals (Sweden)

    Pahwa Priyanka

    2010-01-01

    Full Text Available Haim-Munk syndrome is an extremely rare autosomal recessive disorder of keratinization characterized clinically by palmoplantar hyperkeratosis, severe early onset periodontitis, onychogryphosis, pes planus, arachnodactyly, and acro-osteolysis. Recently, germline mutations in the lysosomal protease cathepsin C gene have been identified as the underlying genetic defect in Haim-Munk syndrome and in the clinically related disorders, such as Papillon-Lefθvre syndrome and prepubertal periodontitis. The periodontal disease associated with these syndromes is particularly aggressive and unresponsive to traditional periodontal therapies. As a result, most patients become edentulous by 15 years of age. This case report describes a patient with the cardinal features of Haim-Munk syndrome.

  2. Combinatorial designs a tribute to Haim Hanani

    CERN Document Server

    Hartman, A

    1989-01-01

    Haim Hanani pioneered the techniques for constructing designs and the theory of pairwise balanced designs, leading directly to Wilson''s Existence Theorem. He also led the way in the study of resolvable designs, covering and packing problems, latin squares, 3-designs and other combinatorial configurations.The Hanani volume is a collection of research and survey papers at the forefront of research in combinatorial design theory, including Professor Hanani''s own latest work on Balanced Incomplete Block Designs. Other areas covered include Steiner systems, finite geometries, quasigroups, and t-designs.

  3. A revision of the Haiming rock avalanche (Eastern Alps)

    Science.gov (United States)

    Dufresne, Anja; Ostermann, Marc; Kelfoun, Karim; Ring, Max; Asam, Dario; Prager, Christoph

    2016-04-01

    The carbonate Haiming rock avalanche is directly neighbouring the larger Tschirgant rock avalanche deposit, both located in the upper Inn valley (Tyrol, Austria). Based on detailed morpho-lithologic mapping of the deposit, which has not been done at Haiming before, the sedimentology of the Holocene landslide debris is characterised. Structural-tectonic elements of the bedrock units at the scarp area are supplemented with borehole data from drillings at the source area giving valuable insights into the complex geological bedrock composition and structure. New source and runout reconstructions allow updated volumetric calculations, which are subsequently integrated into numerical runout modelling. Haiming is one of few topographically unobstructed rock avalanches, yet its morphology was greatly influenced by fluvial terraces, which are still discernible through the deposit on LiDAR hillshade images. We also address the influence of the rock avalanche on the valley floor and local river system as a short-lived dam and its interaction with fluvial incision. Finally, we discuss the Haiming rock avalanche in view of the other massive rock slope failures in the area ("Fernpass cluster"), their spatio-temporal distribution, and point out further highlights of this simple(?) rock avalanche deposit.

  4. Michael Thonet

    Index Scriptorium Estoniae

    2005-01-01

    Saksa päritolu austria mööblidisaineri ja mööblitöösturi Michael Thonet' (1796-1871) disainiloomingust. 1859. a. Michael Thonet' loodud tool nr. 14 on endiselt tootmises ja on tuntud ka Viini toolina. 2 ill

  5. Michael Polanyi, the Scientist

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 23; Issue 1. Comment: Michael Polanyi, the Scientist. John Polanyi. Article-in-a-Box Volume 23 Issue 1 January 2018 pp 15-19. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/023/01/0015-0019. Abstract ...

  6. G S Michael

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science. G S Michael. Articles written in Journal of Earth System Science. Volume 114 Issue 5 October 2005 pp 459-474. Hydrography of the eastern Arabian Sea during summer monsoon 2002 · D Shankar S S C Shenoi R K Nayak P N Vinayachandran G Nampoothiri A M Almeida ...

  7. Klein, Michael L

    Indian Academy of Sciences (India)

    Annual Meetings · Mid Year Meetings · Discussion Meetings · Public Lectures · Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Fellowship. Fellow Profile. Elected: 2006 Honorary. Klein, Michael L FRS. Date of birth: 1940. Address: Director, ICMS, Temple University, CST, SERC Building, 704E, ...

  8. Fisher, Prof. Michael Ellis

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2001 Honorary. Fisher, Prof. Michael Ellis FRS. Date of birth: 3 September 1931. Address: Distinguished Professor Emeritus, Institute of Physical Science and, Technology, University of Maryland, College Park, MD 20742-2431, U.S.A.. Contact: Office: (+1-301) 405 4819

  9. Michael Faraday's Bicentenary.

    Science.gov (United States)

    Williams, L. Pearce; And Others

    1991-01-01

    Six articles discuss the work of Michael Faraday, a chemist whose work revolutionized physics and led directly to both classical field and relativity theory. The scientist as a young man, the electromagnetic experiments of Faraday, his search for the gravelectric effect, his work on optical glass, his laboratory notebooks, and his creative use of…

  10. Following Michael Faraday's Footprints

    Science.gov (United States)

    Galeano, Javier

    2011-01-01

    Last fall I had the good fortune of receiving financial support to shoot a documentary about Michael Faraday. I took the opportunity to learn more about this great experimentalist and to visit the highlights of places in his life. In this paper, I would like to share a list and description of some of the most remarkable places in London suitable…

  11. Michael Faraday, media man.

    Science.gov (United States)

    Fara, Patricia

    2006-03-01

    Michael Faraday was an enthusiastic portrait collector, and he welcomed the invention of photography not only as a possible means of recording observations accurately, but also as a method for advertising science and its practitioners. This article (which is part of the Science in the Industrial Revolution series) shows that like many eminent scientists, Faraday took advantage of the burgeoning Victorian media industry by posing in various roles.

  12. Michael Frayn visits CERN

    CERN Multimedia

    2007-01-01

    Award-winning playwright and novelist Michael Frayn gave a guest lecture in the main auditorium at CERN on Friday 15 March about his new book The Human Touch: Our Part in the Creation of the Universe. The lecture focused on cosmology and philosophy and the limitations that language places on our ability to understand the creation of a universe in which we seem to play such a small part. In addition to his novels and plays, which include Copenhagen, a play about the 1941 meeting between German physicist Werner Heisenberg and Danish physicist Niels Bohr, Frayn has translated several works from Russian, including plays by Chekhov and Tolstoy.

  13. Professor Michael Levitt

    Directory of Open Access Journals (Sweden)

    Gemma-Louise Davies

    2015-10-01

    Full Text Available Professor Michael Levitt (Stanford University, USA won the 2013 Nobel Prize in Chemistry for the development of multiscale models for complex chemical systems—computational tools which can calculate the course of chemical reactions. Professor Levitt was born in Pretoria, South Africa; he came to the UK on a summer vacation aged 16, where he decided to stay and study for his A‑levels. His interest in the physics of living systems drove him to study biophysics at King’s College London, before securing a PhD position at the Laboratory of Molecular Biology in Cambridge. In the interim year between his degree and beginning his PhD, Professor Levitt worked at the Weizmann Institute of Science in Israel, where he met his future wife. They married later that year and moved to Cambridge, where their three children were born. After completing his PhD, he spent time working in Israel, Cambridge, the Salk Institute and Stanford (both California. Since 1986, he has split his time between Israel and California. Outside of science, he is a keen hiker and he is well-known to have attended the eclectic ‘Burning Man’ Festival in California.[1]Professor Levitt visited the University of Warwick to speak at the Computational Molecular Science Annual Conference in March 2015. In this interview, Dr Gemma-Louise Davies, an Institute of Advanced Study Global Research Fellow, spoke to Professor Levitt about the importance of Interdisciplinarity in his field, role models in Academia, and his plans for the future.Image: Professor Michael Levitt (left with Dr Scott Habershon (right, organiser of the 2015 Computational Molecular Science Annual Conference during his visit to the University of Warwick in March 2015.[1] ‘Burning Man’ is a unique annual festival dedicated to community, art, music, self-expression and self-reliance. Tens of thousands of people flock to this temporary metropolis built in the Californian desert.

  14. Michael spaces and Dowker planks

    Directory of Open Access Journals (Sweden)

    Agata Caserta

    2009-10-01

    Full Text Available We investigate the Lindelöf property of Dowker planks. In particular, we give necessary conditions such that the product of a Dowker plank with the irrationals is not Lindelöf. We also show that if there exists a Michael space, then, under some conditions involving singular cardinals, there is one that is a Dowker plank.

  15. Michael Polanyi's Philsophy of Science

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 23; Issue 1. Michael Polanyi's Philsophy of Science. B Subramanian. Article-in-a-Box Volume 23 Issue 1 January 2018 pp 21-22. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/023/01/0021-0022. Abstract ...

  16. Michael Beitz: Objects of Communication

    Science.gov (United States)

    Hoefferle, Mary

    2014-01-01

    For this Instructional Resource, the author interviewed contemporary sculptor Michael Beitz, who uses art to explore the role of designed objects in human communication and emotional experience. This column was written in response to calls for using Enduring Understandings/Big Ideas (National Coalition for Core Arts Standards, 2013; Stewart &…

  17. A Conversation with Michael Byram

    Science.gov (United States)

    Wagner, Manuela

    2013-01-01

    In language teaching, it has been universally acknowledged that students need not just knowledge and skill in the grammar of a language but also the ability to use the language in socially and culturally appropriate ways. In this article Michael Byram, who has been working on Intercultural Competence for quite some time in a variety of different…

  18. Michael J. Fox: Spurring Research on Parkinson's

    Science.gov (United States)

    ... please turn JavaScript on. Feature: Parkinson's Disease Michael J. Fox: Spurring Research on Parkinson's Past Issues / Winter 2014 Table of Contents Michael J. Fox and his wife, actress Tracy Pollan, founded ...

  19. Michael Niegl (1985-2009)

    CERN Multimedia

    2009-01-01

    Our friend and colleague Michael Niegl died in a tragic accident in the first hours of the new year. Michael was a Master’s student in Microsystems Engineering at the University of Applied Sciences Wiener Neustadt. He was responsible for the development of the ATLAS Beam Conditions Monitor (BCM) ROD FPGA firmware, which acquires the data from the BCM detector modules and provides online monitoring of the LHC beams within the ATLAS experiment. He spent several months at CERN to carry out beam tests on the BCM detectors and received his Bachelor of Science with first class honours for his thesis: Concept and Implementation of an FPGA-based Data Recorder and Processor for the ATLAS Beam Conditions Monitor. Michael spent six months at CERN last year to finish the development and commissioning of the ROD firmware for the first beam. He worked the entire night of 10 September to fine tune the system for the first beam. It was a joy to ...

  20. Michael De Sousa (1989 - 2012)

    CERN Multimedia

    2012-01-01

    We are deeply saddened to announce the death of Mr Michael De Sousa on 13 May 2012. Mr De Sousa, who was born on 02.09.1989, was working as an apprentice in the TE Department and had been at CERN since 24.08.2009. The Director-General has sent a message of condolence to his family on behalf of the CERN personnel. Social Affairs Human Resources Department     It is with great emotion and deep sadness that we learn of the tragic loss of our colleague and friend Michael De Sousa. Michael was a hard working colleague, cordial and considerate. Within a few months, he marked his presence by the implementation of the instrumentation benches for gas permeation measurement in polymers, and the calibration of high technology gas analyzers, necessary for vacuum technology. His last contribution will enable us to measure pressures in the extreme high vacuum range for the ELENA project.  With the continuation of this activity, his memory will remain. His accomplishments will remain...

  1. Le radicalisme de Michael Moore Michael Moore’s Radicalism

    Directory of Open Access Journals (Sweden)

    Jean-Marie Ruiz

    2004-01-01

    Full Text Available Michael Moore is famous and popular in many European countries, where he is seen as a critic of American culture. However, his main thesis, which is repeatedly expressed in his films and books, does not primarily criticize American popular culture or political tradition. Rather, this article argues that Moore’s thought may best be analysed through the American tradition of radicalism, whose origin dates back to Thomas Paine. Obviously, Moore is a contemporary radical who uses the modern media to reach as many people as possible. Yet some aspects of his rationale are surprisingly close to 18th century American radicalism.

  2. Video interview with Michael Dell

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    Michael Dell, founder and presently Chairman of the Board of Directors and Chief Executive Office of the DELL computer company visited CERN on Tuesday 26th January 2010. The Bulletin and the Video productions team had the opportunity to meet him. The video interview is transcribed for your convenience.   Michael S. Dell with CERN Director-General Rolf Heuer. What motivated you to come and visit CERN? I obviously heard about the great science and research has going on here, and DELL is very pleased to be a partner and providing a lot of the computers to analyse the data and I really wanted to see for myself in person, some of the great science that is going on here. What is your view on fundamental research in IT, and in general? I think if you look at the field of science in the last hundred years, we have been able to solve a lot of problems, but there are still lots of unsolved problems and unsolved mysteries. And it is only through basic fundamental research that we will address these probl...

  3. Method for promoting Michael addition reactions

    Science.gov (United States)

    Shah, Pankaj V.; Vietti, David E.; Whitman, David William

    2010-09-21

    Homogeneously dispersed solid reaction promoters having an average particle size from 0.01 .mu.m to 500 .mu.m are disclosed for preparing curable mixtures of at least one Michael donor and at least one Michael acceptor. The resulting curable mixtures are useful as coatings, adhesives, sealants and elastomers.

  4. Enantioselective aminocatalysis: Michael addition of unactivated ...

    Indian Academy of Sciences (India)

    KHIANGTE VANLALDINPUIA

    derived from α-amino acids and carbohydrates for asymmetric Michael addition in solvent-free conditions. Given the importance of stereoselective Michael addi- tion of carbonyl compounds to nitroalkenes42 in the synthesis of synthetically useful γ-nitro carbonyl com- pounds,43–45 Ma and co-workers reported bifunctional.

  5. [Early career of Michael Sendivogius].

    Science.gov (United States)

    Prinke, Rafał T

    2012-01-01

    One of the most influential alchemical authors of the early modern period was Michael Sendivogius whose early life is shrouded in mystery. He may be labelled the most famous Polish scientific writer between Copernicus and Marie Skłodowska-Curie, but because of the difficulties involved in researching the biography of any alchemist, there has been relatively little interest in him among Polish historians. The early work of Roman Bugaj (author of the still fundamental monograph) and Włodzimierz Hubicki (who made his research available to the international community) has been continued only by the English-born Zbigniew Szydło and the author of this article. The roots of many legends about Sendivogius were three mid-17th century short biographies, none of which is trustworthy, so it is crucial to verify the received myth and the version constructed in the 1960's and 1970's with primary sources and evidence from the recent "new historiography of alchemy". The present article examines them in the light of newly discovered sources and reinterpretation of the old ones. The genealogy of the Sedzimir family is discussed at length to show that Sendivogius most probably was not its member but only a pretender in order to assume (or prove) the status of a nobleman. Several possible hypotheses about his origins are presented. He is known to have studied at three universities (Leipzig, Vienna and Altdorf) but authors of early panegyrics dedicated to Sendivogius list more universities which he may have attended. The most interesting is that of Cambridge, listed as the first one, because practically no Poles or Czechs went there at the time. Finally, his marriage to Veronica Stiebar, a wealthy widow of a Franconian knightly family, and her interesting family relationships (links to Erasmus, Camerarius, Paracelsus and the original Doctor Faustus) are discussed. The period covered is that before Sendivogius moved to Prague in about 1597, having already been a courtier of Rudolf II

  6. ASK Talks with Dr. Michael Hecht

    Science.gov (United States)

    Hecht, Michael

    2003-01-01

    Michael Hecht has been a member of NASA's Jet Propulsion Laboratory (JPL) staff since 1982. He is currently Project Manager and co-investigator for the Mars Environmental Compatibility Assessment (MECA)

  7. Michael J. Fox Foundation for Parkinson's Research

    Science.gov (United States)

    ... 2014 2015 2016 Our single, urgent goal: Eliminate Parkinson's disease in our lifetime. Today we are the ... 20 years since he publicly disclosed he has Parkinson's, Michael J. Fox sits down with Jane Pauley ...

  8. Michael G. Brennan: George Orwell and Religion

    Directory of Open Access Journals (Sweden)

    Jeremy Crump

    2016-11-01

    Full Text Available This contribution offers a review of: Michael G. Brennan: George Orwell and Religion. Bloomsbury Academic: London/Oxford/New York/New Delhi/Sydney, 2016. 208 pages, $94.00/£70.00, ISBN (hardback 9781472531940.

  9. A Bibliographic Tribute to Jack Michael

    Science.gov (United States)

    Esch, Barbara E.; Esch, John W.

    2016-01-01

    "In the late 1950's, Jack Michael, a bright but irritating young psychology instructor, moved from the Universities of Kansas to Houston to Arizona State. Along the way he befriended two nontraditional students, protected them through their Ph.D. programs, and turned them loose on the world: Teodoro Ayllon…and Montrose Wolf…" (Risley,…

  10. Enantioselective aminocatalysis: Michael addition of unactivated ...

    Indian Academy of Sciences (India)

    Although there is a report on stereoselective organocatalysis in Michael addition employing monofunctional secondary amine, the use of monofunctional primary amine forthe said reaction is not reported till date. In fact, no monofunctional aminocatalyst is reported yet for the synthesis γ-nitro carbonyl compounds. Here we ...

  11. Reframing Michael Scott: Exploring Inappropriate Workplace Communication

    Science.gov (United States)

    Schaefer, Zachary A.

    2010-01-01

    Individuals who work in professional settings interact with others who may exhibit a variety of cultural beliefs and decision-making approaches. Page (2007) argues that cognitive diversity (i.e., how people approach and attempt to solve problems) is a vital asset in effective organizations. Michael Scott, who portrays the inept main character on…

  12. Michael Sadler and the German Connection.

    Science.gov (United States)

    Higginson, J. H.

    1990-01-01

    Chronicles works of Michael Sadler who compared British and German educational systems, emphasizing Germany's contributions in technical education. Presents Sadler's 1912 recommendations--eight lessons premised upon powerful centralized government's ability to implement policy. Reflects on how World War I and Nazism influenced Sadler's thought and…

  13. Reflections: Michael Watts interviewed by Murat Arsel

    NARCIS (Netherlands)

    M. Arsel (Murat)

    2009-01-01

    textabstractMichael Watts is ‘Class of 1963’ Chair in Undergraduate Studies and Chancellor’s Professor of Geography at the University of California, Berkeley. Born and raised in rural southwest England, Watts studied at University College London and completed his PhD in 1979 at the University of

  14. Multicomponent, Enantioselective Michael-Michael-Aldol-β-Lactonizations Delivering Complex β-Lactones.

    Science.gov (United States)

    Van, Khoi N; Romo, Daniel

    2018-01-19

    Optically active, tertiary amine Lewis bases react with unsaturated acid chlorides to deliver chiral, α,β-unsaturated acylammonium salts. These intermediates participate in a catalytic, enantioselective, three-component process delivering bi- and tricyclic β-lactones through a Michael-Michael-aldol-β-lactonization. In a single operation, the described multicomponent, organocascade process forms complex bi- and tricyclic β-lactones by generating four new bonds, two rings, and up to four contiguous stereocenters. In the racemic series, yields of 22-75% were achieved using 4-pyrrolidinopyridine as Lewis base. In the enantioselective series employing isothiourea catalysts, a kinetic resolution of the initially formed racemic Michael adduct appears operative, providing yields of 46% to quantitative (based on 50% max) with up to 94:6 er. Some evidence for a dynamic kinetic asymmetric transformation for tricyclic-β-lactone 1d was obtained following optimization (yields up to 61%, 94:6 er) through a presumed reversible Michael.

  15. Michael Haneke film Euroopa parim / M. T.

    Index Scriptorium Estoniae

    M. T.

    2005-01-01

    IX PÖFFil linastuv Michael Haneke film "Varjatud" ("Cache") võitis laupäeval mitu Euroopa Filmiakadeemia auhinda, selhulgas parima filmi, parima lavastaja, parima meesnäitleja (Daniel Auteuil) ja FIPRESCI auhinna. Parim naisnäitleja - Julia Jentsch ("Sophie Scholli viimased päevad"), operaator - Franz Lustig ("Don't Come Knocking"), stsenaarium - Hany Abu-Assad, Bero Beyer ("Kohe paradiisi")

  16. Michael Scot and the Four Rainbows

    Directory of Open Access Journals (Sweden)

    Tony Scott

    2017-06-01

    Full Text Available We apply a physical and historical analysis to a passage by the medieval scholar Michael Scot concerning multiple rainbows, a meteorological phenomenon whose existence has only been acknowledged in recent history. We survey various types of physical models to best decipher Scot’s description of four parallel rainbows as well as a linguistic analysis of Scot’s special etymology. The conclusions have implications on Scot’s whereabouts at the turn of the 13th century.

  17. Obituary: Michael James Ledlow, 1964-2004

    Science.gov (United States)

    Puxley, Philip John; Grashuis, Randon M.

    2004-12-01

    Michael James Ledlow died on 5 June 2004 from a large, unsuspected brain tumor. Since 2000 he had been on the scientific staff of the Gemini Observatory in La Serena, Chile, initially as a Science Fellow and then as a tenure-track astronomer. Michael was born in Bartlesville, Oklahoma on 1 October 1964 to Jerry and Sharon Ledlow. He obtained his Bachelor Degree in astrophysics at the University of Oklahoma in 1987 and attended the University of New Mexico for his graduate work, obtaining his PhD while studying Galaxy Clusters under Frazer Owen in 1994. From 1995-1997 Michael held a postdoctoral position with Jack Burns at New Mexico State University where he used various astronomical facilities including the VLA and Apache Point Observatory to study distant galaxies. From 1998-2000 Michael rejoined the Physics and Astronomy Department at the University of New Mexico where he was a visiting professor until he moved on to Gemini. At the Gemini Observatory, Mike shared in the excitement, hard work and many long days and nights associated with bringing on-line a major new astronomical facility and its instrumentation. Following its commissioning he assisted visiting observers, supported and took data for many more remote users via the queue system, and for each he showed the same care and attention to detail evident in his own research to ensure that all got the best possible data. His research concentrated on the radio and optical properties of galaxy clusters, especially rich Abell clusters such as A2125, on luminous radio galaxies, including the detection of a powerful double radio source in the "wrong sort of galaxy," the spiral system 0313-192, and on EROs (extremely red objects), dusty galaxies barely detectable at optical wavelengths. Michael thoroughly enjoyed living in Chile and enthusiastically immersed himself in the culture of his surroundings. He and his family were actively involved with the International English Spanish Association in La Serena. He had a

  18. Anne Michaels e le ferite del linguaggio

    Directory of Open Access Journals (Sweden)

    Oriana Palusci

    2014-04-01

    Fugitive Pieces is analysed taking into consideration its polyphonic structure, the manifold motives and threads that weave together an intricate pattern, based on historical events and personal stories. Thanks to her use of scientific language from the realm of geology, paleobotany and geography, Michaels excavates time and space, past and present, in order to find a language to unveil the atrocities of Nazism against Jews, to preserve and evoke the memories of the survivors, but at the same time lead to a possible reconciliation with the past.

  19. Michael Roitmann : Kalandus ei ole Eestile ilmselt prioriteetne valdkond / Michael Roitmann ; interv. Marko Saaret

    Index Scriptorium Estoniae

    Roitmann, Michael

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 3. dets. lk. 9. Euroopa Komisjoni kalandusdirektoraadi koordinaator Euroopa Liidu laienemise küsimuses Michael Roitmann juhib tähelepanu Eesti kalanduse suurematele probleemidele ning prognoosib EL-iga liitumise mõju Eesti kalandussektori arengule

  20. Michael Faraday and his contribution to anesthesia.

    Science.gov (United States)

    Bergman, N A

    1992-10-01

    Michael Faraday (1791-1867) was a protégé of Humphry Davy. He became one of Davy's successors as Professor of Chemistry at the Royal Institution of Great Britain. Of Faraday's many brilliant discoveries in chemistry and physics, probably the best remembered today is his work on electromagnetic induction. Faraday's contribution to introduction of anesthesia was his published announcement in 1818 that inhalation of the vapor of ether produced the same effects on mentation and consciousness as the breathing of nitrous oxide. He most likely became familiar with the central nervous system effects of nitrous oxide through his association with Davy, an avid user of the gas. Sulfuric ether was a common, convenient, cheap, and easily available substance, in contrast to nitrous oxide, which required expensive, cumbersome, and probably not widely available apparatus for its production and administration. The capability for inhaling intoxicating vapors eventually became commonly available with the use of ether instead of the gas. The first surgical anesthetics were a consequence of the resulting student "ether frolics." The 1818 announcement on breathing ether vapor was published anonymously; however, notations in Faraday's handwriting in some of his personal books clearly establish Michael Faraday as the author of this brief communication.

  1. Michael Faraday's Contributions to Archaeological Chemistry.

    Science.gov (United States)

    Moshenska, Gabriel

    2015-08-01

    The analysis of ancient artefacts is a long but largely neglected thread within the histories of archaeology and chemistry. This paper examines Michael Faraday's contributions to this nascent field, drawing on his published correspondence and the works of his antiquarian collaborators, and focusing in particular on his analyses of Romano-British and ancient Egyptian artefacts. Faraday examined the materials used in ancient Egyptian mummification, and provided the first proof of the use of lead glazes on Roman ceramics. Beginning with an assessment of Faraday's personal interests and early work on antiquities with Humphry Davy, this paper critically examines the historiography of archaeological chemistry and attempts to place Faraday's work within its institutional, intellectual, and economic contexts.

  2. Michael Maier--nine newly discovered letters.

    Science.gov (United States)

    Lenke, Nils; Roudet, Nicolas; Tilton, Hereward

    2014-02-01

    The authors provide a transcription, translation, and evaluation of nine newly discovered letters from the alchemist Michael Maier (1568-1622) to Gebhardt Johann von Alvensleben (1576-1631), a noble landholder in the vicinity of Magdeburg. Stemming from the final year of his life, this correspondence casts new light on Maier's biography, detailing his efforts to secure patronage amid the financial crisis of the early Thirty Years' War. While his ill-fated quest to perfect potable gold continued to form the central focus of his patronage suits, Maier also offered his services in several arts that he had condemned in his printed works, namely astrology and "supernatural" magic. Remarks concerning his previously unknown acquaintance with Heinrich Khunrath call for a re-evaluation of Maier's negotiation of the discursive boundaries between Lutheran orthodoxy and Paracelsianism. The letters also reveal Maier's substantial contribution to a work previously ascribed solely to the English alchemist Francis Anthony.

  3. Enantioselective construction of spirocyclic oxindoles via Tandem michael/Michael reactions catalyzed by multifunctional quaternary phosphonium salt

    National Research Council Canada - National Science Library

    Hongyu Wang; Yongjia Shang; Dongdong Cao; Jiaxing Zhang; Gang Zhao; Changwu Zheng

    2016-01-01

    The enantioselective construction of five-membered spirocyclic oxindoles via a double Michael cascade reaction is described by using dipeptide-based multifunctional quaternary phosphonium salt catalysts...

  4. Language and Intercultural Education: An Interview with Michael Byram

    Science.gov (United States)

    Porto, Melina

    2013-01-01

    This article reports an interview with Michael Byram, Professor Emeritus, University of Durham in the United Kingdom, during his visit to Argentina in September 2011. Michael Byram is one of the main international referents in intercultural education. The interview addresses issues such as language education, intercultural and citizenship…

  5. Book Review: Invitation to Topological Robotics by Michael Farber

    DEFF Research Database (Denmark)

    Raussen, Martin

    2009-01-01

    Book Review: Invitaton to Topological Robotics by Michael Farber. Zurich Lectures in Advanced Mathematics, European Mathematical Society (2008), ISBN 978-3-03719-054-8......Book Review: Invitaton to Topological Robotics by Michael Farber. Zurich Lectures in Advanced Mathematics, European Mathematical Society (2008), ISBN 978-3-03719-054-8...

  6. Obituary: Michael John Klein, 1940-2005

    Science.gov (United States)

    Gulkis, Samuel

    2006-12-01

    Michael John Klein died on 14 May 2005 at home in South Pasadena, California. The cause of death was tongue cancer that metastasized to the lungs. He was a non-smoker. Mike was a passionate radio astronomer, a trusted astronomical observer, an educator and a family man. Mike was born on 19 January 1940 in Ames, Iowa, the son of Florence Marie (Graf) and Fred Michael Klein. His mother was a homemaker, and his father was a banker. Mike had two older sisters, Lois Jean (Klein) Flauher and Marilyn June (Klein) Griffin. In 1962, Mike married his high school sweetheart Barbara Dahlberg, who survives him along with their three children, Kristin Marie (Klein) Shields, Michael John Klein Jr., Timothy Joel Klein, and six grandchildren. Mike developed a love for astronomy early in his life, and credited an early morning, newspaper-delivery route that he had at age twelve, which took him outside well before sunrise. He told family members that as he walked along his route, he stared into the sky and wondered what everything was. He studied sky charts, located stars, and began to understand how the planets shifted their positions relative to the stars each day. Another big influence in Mike's life was his brother in-law, Jim Griffin. Jim helped Mike understand that his passion for science did not have to remain a hobby, but could and should become a career. Jim's encouragement led Mike to attend Iowa State University in Ames, where he earned a BS in electrical engineering in 1962. Mike then started graduate school in electrical engineering at Michigan State, but after one semester transferred to the University of Michigan, Ann Arbor, where he earned an MS (1966) and PhD (1968) in astronomy. His doctoral dissertation, under the direction of Professor Fred Haddock, was based on extensive observations of the planets and examined the physical and thermal properties of planetary atmospheres and surfaces. Mike was awarded a Resident Research Associate position at JPL by the National

  7. Two papers by Michael Fordham (d.1995).

    Science.gov (United States)

    Astor, James

    2010-11-01

    The Journal has decided to publish a selection of previously unpublished papers from the Michael Fordham archives, which are being prepared for publication by James Astor and Elizabeth Urban, and of which the two papers published here are the first, both dating from the 1950s. 'Analyst and Priest' seems to be addressed to an audience of mainly religious people who are interested in the relation between psychology and religion and to whom Fordham is introducing some basic Jungian concepts and ways of thinking. The analyst in this lecture is the advocate of a new science, the priest an established figure with a role in society and rituals to perform. As the paper progresses he refines the differences between priest and analyst in terms of individual development versus a philosophy of life. The paper ends with a plea for co-operation between priest and analyst. 'Analyst and Scientist' was a radio talk given in 1956. In this paper Fordham makes the case for paying attention to the irrational. He draws support from Pauli and Polanyi. His theme is to show the scientific value of the subjective. From this he describes the scientific basis for Jung's comparative method and consequently of archetypal psychology. © 2010, The Society of Analytical Psychology.

  8. Michael Tooley on possible people and promising.

    Science.gov (United States)

    Kuhse, H

    1993-01-01

    This critique takes issue with the arguments that Michael Tooley forwarded in "Abortion and Infanticide" to further the notion that the destruction of potential persons is not immoral. In particular, the author focuses on Tooley's presupposition that it is not wrong to prevent the existence of additional persons who are likely to lead happy lives. The writings of Derek Parfit are called upon to provide examples upon which the criticism of Tooley is based. Particular attention is paid to two scenarios proposed by Parfit: one in which a pregnant woman would be wrong to refuse a simple treatment to prevent a handicap in her baby and the other in which a woman planning to become pregnant is advised to wait three months before becoming pregnant to allow herself time to recover from a condition which would result in her having a handicapped child. Parfit suggests that it would be wrong of the woman not to wait. Of course, the problem inherent in the second scenario is that the woman would harm her potential handicapped child by not allowing its conception. Tooley's reconciliation of the problems posed by Parfit are based on the morality involved in making and keeping promises. The author reviews Tooley's attempt to justify his views in this way and concludes that Tooley's reasoning fails, in part because promising is only a social institution, and morality also encompasses basic values. If one accepts Tooley's argument that there is an obligation to refrain from bringing wretched people into the world, then one must also accept the reverse: an obligation exists to bring additional happy people into the world. In this case, both abortion and infanticide are wrong.

  9. catalysis of the michael reactions by n,n'-dimethylaminopropyl

    African Journals Online (AJOL)

    a

    modification and via sol-gel copolymerisation processes are active catalysts in the Michael reaction. However, the latter report does not show detailed physicochemical properties of the material developed by the sol-gel method. In addition, effects ...

  10. Michael Akam and the rise of evolutionary developmental biology.

    Science.gov (United States)

    Stern, David L; Dawes-Hoang, Rachel E

    2010-01-01

    Michael Akam has been awarded the 2007 Kowalevsky medal for his many research accomplishments in the area of evolutionary developmental biology. We highlight three tributaries of Michaels contribution to evolutionary developmental biology. First, he has made major contributions to our understanding of development of the fruit fly, Drosophila melanogaster. Second, he has maintained a consistent focus on several key problems in evolutionary developmental biology, including the evolving role of Hox genes in arthropods and, more recently, the evolution of segmentation mechanisms. Third, Michael has written a series of influential reviews that have integrated progress in developmental biology into an evolutionary perspective. Michael has also made a large impact on the field through his effective mentorship style, his selfless promotion of younger colleagues, and his leadership of the University Museum of Zoology at Cambridge and the European community of evolutionary developmental biologists.

  11. Yuriko and Michael Renardy reappointed Class of 1950 Professors

    OpenAIRE

    Owczarski, Mark

    2010-01-01

    Yuriko and Michael Renardy, professors of mathematics in the College of Science at Virginia Tech, have been reappointed as the Virginia Tech Class of 1950 Professors by the Virginia Tech Board of Visitors.

  12. Meet EPA Scientist Michael Nye, Ph.D.

    Science.gov (United States)

    Michael Nye, Ph.D., is a social scientist who studies natural risk, socio-demographic change and sustainable behavior. Prior to joining EPA, he worked for the UK Environment Agency in flood risk management and emergency preparedness

  13. MICHAEL B. KATZ: 13 APRIL 1939 23 AUGUST 2014

    National Research Council Canada - National Science Library

    Elaine L Simon

    2016-01-01

      The author met Michael Katz when he and a group of students he had involved in the search for a new assistant director for Penn's Urban Studies program interviewed me for the position 28 years ago...

  14. Principles of Chemistry (by Michael Munowitz)

    Science.gov (United States)

    Kovac, Reviewed By Jeffrey

    2000-05-01

    At a time when almost all general chemistry textbooks seem to have become commodities designed by marketing departments to offend no one, it is refreshing to find a book with a unique perspective. Michael Munowitz has written what I can only describe as a delightful chemistry book, full of conceptual insight, that uses a novel and interesting pedagogic strategy. This is a book that has much to recommend it. This is the best-written general chemistry book I have ever read. An editor with whom I have worked recently remarked that he felt his job was to help authors make their writing sing. Well, the writing in Principles of Chemistry sings with the full, rich harmonies and creative inventiveness of the King's Singers or Chanticleer. Here is the first sentence of the introduction: "Central to any understanding of the physical world is one discovery of paramount importance, a truth disarmingly simple yet profound in its implications: matter is not continuous." This is prose to be savored and celebrated. Principles of Chemistry has a distinct perspective on chemistry: the perspective of the physical chemist. The focus is on simplicity, what is common about molecules and reactions; begin with the microscopic and build bridges to the macroscopic. The author's perspective is clear from the organization of the book. After three rather broad introductory chapters, there are four chapters that develop the quantum mechanical theory of atoms and molecules, including a strong treatment of molecular orbital theory. Unlike many books, Principles of Chemistry presents the molecular orbital approach first and introduces valence bond theory later only as an approximation for dealing with more complicated molecules. The usual chapters on descriptive inorganic chemistry are absent (though there is an excellent chapter on organic and biological molecules and reactions as well as one on transition metal complexes). Instead, descriptive chemistry is integrated into the development of

  15. Entrevista al profesor D. Michael Walker. - Interview with Professor D. Michael Walker.

    Directory of Open Access Journals (Sweden)

    Caravaca Guerrero, Consuelo Isabel

    2014-12-01

    Full Text Available Entrevistar a un investigador de la talla de D. Michael Walker supone hablar de un investigador reconocido a nivel nacional e internacional, uno de los mayores expertos en evolución humana de nuestros días. Nació en Colchester (Inglaterra en 1941 y tiene doble nacionalidad: británica y australiana. Actualmente es profesor emérito de la Universidad de Murcia en el Departamento de Zoología y Antropología Física de la Facultad de Biología. Pero su currículum no acaba aquí, Michael realizó tres carreras, Fisiología Animal, Medicina, y Arqueología Prehistórica, en la Universidad de Oxford. Es Doctor por esta universidad, gracias a su tesis leída sobre Paleoantropología y Prehistoria de las cuencas de los ríos Segura y Vinalopó. Nuestro entrevistado, también fue elegido Académico (Fellow –F.S.A.- en 1988 de la Society of Antiquaries of Londono SAL. Fundada en 1707, la SAL es la equivalente británica de la española Real Academia de la Historia. Es Fellow también del Real Instituto Antropológico de la Gran Bretaña (Royal Anthropological Institute of Great Britain y socio emérito de la Asociación Americana de Antropólogos Físicos (American Association of Physical Anthropologists.

  16. Guest Foreword from Michael Thomas CMG QC

    Directory of Open Access Journals (Sweden)

    Michael Thomas

    2012-04-01

    precedents and thought in a unique legal market in which ideas drawn from Islamic law, civil law and common law can intermingle and blend. It is not surprising therefore to see that this new publication will be dedicated to the subject of international law, both public and private. Its laudable aim is to promote legal discourse around the world, and to promote a wider international understanding of contemporary legal issues for the common benefit. As an open access, bilingual journal, addressing topics concerning any jurisdiction, I hope it will reach a wide audience, and fulfil its aim of promoting understanding between different cultures. I am sure that the journal will not only benefit Qatar’s legal community by advancing academic and practice-based legal discussion. I am also confident that it will stimulate thought in the global legal community at large. May I wish it every success and a long life. Michael Thomas CMG QC

  17. Obituary: Michael John Seaton, 1923-2007

    Science.gov (United States)

    Pradhan, Anil; Nahar, Sultana

    2007-12-01

    Professor Michael John Seaton, hailed as the "Father of Atomic Astrophysics," passed away on May 29, 2007. He was one of the few Honorary Fellows of both the American Astronomical Society and the American Physical Society, so honored for his monumental contributions to both physics and astronomy. Mike Seaton was born on January 16, 1923 in Bristol, England. He attended Wallington County High School. But his leftist political activities, even at that stage, led to his expulsion, though he was eventually allowed to matriculate. He enlisted in the Royal Air Force as a navigator during the Second World War, and flew many dangerous missions. His legendary concentration and precision are reflected in the following anecdote. Once after a bombing mission his aircraft was lost in fog over the Alps. Seaton calculated the position and coordinates in flight to guide the aircraft. When the fog lifted, the crew found themselves flying perilously close to the mountains, but made it safely back. His associates often said, "A Seaton calculation is carried out as if his life depended on it." After the War he was admitted to University College London (UCL) as an undergraduate. Thereafter, he spent all of his professional career at UCL. Seaton received his Batchelor's degree in 1948, and his Ph.D. in 1951. His tenure at UCL coincided with the golden age of atomic astrophysics, for he was largely responsible for it. Seaton was elected Fellow of the Royal Society in 1967, and as President of the Royal Astronomical Society (RAS) in 1978. He was the recipient of an Honorary Doctorate from the Observatoire de Paris, an Honorary D.Sc. from the Queen's University of Belfast, the Gold Medal for Astronomy by the RAS, the Guthrie Medal by the Institute of Physics, the Royal Society Hughes award for lifetime work by the RAS, and several other prestigious awards. Nevertheless, as Alex Dalgarno recently remarked, Seaton was not part of the establishment because he chose not to be. Though rooted in

  18. Developing Successful Retention Programs: An Interview with Michael Hovland.

    Science.gov (United States)

    Kluepfel, Gail A.; Hovland, Michael

    1994-01-01

    Michael Hovland, the senior consultant at Noel-Levitz Centers, responds to questions about summer bridge programs, first-year seminar programs, Rutgers' retention model, faculty reactions to retention programs, the impact of retention programs on institutional mission, administrative involvement in retention, student assessment, retention efforts…

  19. Solvent-free microwave-mediated Michael addition reactions

    Indian Academy of Sciences (India)

    Facile Michael addition of active methylene compounds to ,-unsaturated carbonyl compounds takes place on the surface of potassium carbonate under microwave irradiation. Further studies on microwave-mediated Robinson annulations reveal a convenient and facile method for condensation of chalcone with ...

  20. Aza-Michael Reaction for an Undergraduate Organic Chemistry Laboratory

    Science.gov (United States)

    Nigam, Manisha; Rush, Brittney; Patel, Jay; Castillo, Raul; Dhar, Preeti

    2016-01-01

    A green, aza-Michael reaction is described that can be used to teach undergraduate students conjugate addition of nitrogen nucleophile to an a,ß-unsaturated ester. Students analyze spectral data of the product obtained from the assigned reaction to determine product structure and propose the mechanism of its formation. The experiment requires…

  1. The correspondence of Michael Faraday, v.4 1849-1855

    CERN Document Server

    James, F

    2008-01-01

    This volume includes 70% of previously unpublished letters of Michael Farday spanning half of the 1850s and most of 1860. Topics include Faraday's work on regelation, the transmission of light through gold and his appointment by Emperor Napoleon III to be a Commander of the Legion of Honour.

  2. Proof Positive: Q&A with Michael Fullan

    Science.gov (United States)

    Crow, Tracy

    2009-01-01

    This article presents an interview with Michael Fullan, an internationally recognized expert in educational change. A prolific writer and speaker, Fullan has worked in schools and educational systems around the world, including his home province of Ontario, Canada. He partners with a variety of projects designed to engineer school improvement and…

  3. Shaping the Global Civil Society: An Interview with Michael Peters

    Science.gov (United States)

    Heraud, Richard; Tesar, Marek

    2017-01-01

    Professor Michael A. Peters has worked in an era of transformation that has taken him from a labour-intensive paper-based form of production to the computerised reproduction of thought, and the current shift in the publishing landscape from a reader-subscription to an author-pays model. Most of what he has learned in publishing and editing he has…

  4. Berliinis võidutses Michael Haneke / Jüri Laulik

    Index Scriptorium Estoniae

    Laulik, Jüri, 1959-

    2005-01-01

    IX PÖFFil linastuv Michael Haneke film "Varjatud" ("Cache") võitis laupäeval mitu Euroopa Filmiakadeemia auhinda, sealhulgas parima filmi, parima lavastaja ja parima meesnäitleja (Daniel Auteuil) auhinna. Parima naisnäitleja tiitli pälvis Julia Jentsch ("Sophie Scholli viimased päevad"). Elutööpreemia sai sir Sean Connery

  5. Tweeting Prayers and Communicating Grief over Michael Jackson Online

    Science.gov (United States)

    Sanderson, Jimmy; Cheong, Pauline Hope

    2010-01-01

    Death and bereavement are human experiences that new media helps facilitate alongside creating new social grief practices that occur online. This study investigated how people's postings and tweets facilitated the communication of grief after pop music icon Michael Jackson died. Drawing on past grief research, religion, and new media studies, a…

  6. Michael Moore kaevati kohtusse pettuse eest / Mari Rebane

    Index Scriptorium Estoniae

    Rebane, Mari

    2006-01-01

    Dokumentaalfilm "9/11 Fahrenheiti" ("Fahrenheit 9/11") : režissöör Michael Moore : USA 2004. Iraagi sõja invaliidistunud veteran andis režissööri kohtusse teda kujutavate flmikaadrite loata ja tenentsliku kasutamise pärast

  7. Eesti luksushotellide ristiisa / Michael Stenner ; interv. Malle Koido

    Index Scriptorium Estoniae

    Stenner, Michael

    2007-01-01

    Eesti tipphotelle 1997. aastast juhtinud sakslane, praegu hotellide Kolm Õde ja Telegraaf juht räägib Eesti ja Saksamaa erinevustest, Eesti hotelliärist, teeninduskultuurist ja personalist. Lisa: Kes on Michael Stenner ning kuidas ta Eestisse sattus? Ilmunud ka: Linnaleht : Pärnu, 23. veebr. 2007, lk. 5-6

  8. Michael hydratase alcohol dehydrogenase or just alcohol dehydrogenase?

    NARCIS (Netherlands)

    Resch, V.A.; Jin, J.; Chen, B.S.; Hanefeld, U.

    2014-01-01

    The Michael hydratase – alcohol dehydrogenase (MhyADH) from Alicycliphilus denitrificans was previously identified as a bi-functional enzyme performing a hydration of ?,?-unsaturated ketones and subsequent oxidation of the formed alcohols. The investigations of the bi-functionality were based on a

  9. Editorial: Juba College of Nursing and Midwifery | Michael | South ...

    African Journals Online (AJOL)

    Editorial: Juba College of Nursing and Midwifery. Janet Michael. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

  10. Entretien avec Michael Quinn Patton | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    utilité est pratique courante. Mais qu'en est-il de l'efficacité et de l'utilité des évaluations elles-mêmes ? Michael Quinn Patton, évaluateur de renommée internationale, était récemment au CRDI pour expliquer son approche ...

  11. Terroristid on võitmas / Michael Weiss ; intervjueerinud Taavi Minnik

    Index Scriptorium Estoniae

    Weiss, Michael

    2016-01-01

    Intervjuu Ameerika Ühendriikide ajakirjaniku ja Islamiriigi asjatundja Michael Weissiga, kes räägib, miks liituvad tuhanded Euroopas kasvanud mosleminoored džihadistidega ning kuidas deradikaliseerida läänemaailmas elavaid äärmuslastest moslemeid

  12. "No More Excuses": Michael M. Crow on Analytics

    Science.gov (United States)

    Crow, Michael M.

    2012-01-01

    Michael M. Crow became the 16th president of Arizona State University in July 2002, with the goal of transforming ASU into what he calls a "New American University"--an institution combining the highest levels of academic excellence, inclusiveness to a broad demographic, and maximum societal impact. His view included increasing graduate…

  13. Professor Porter ja tema viis konkurentsitegurit / Michael E Porter

    Index Scriptorium Estoniae

    Porter, Michael E

    2008-01-01

    Maailmas tuntud juhtimisguru Michael Porter viie konkurentsijõu teooriast ja selle rakendatavusest erinevates valdkondades. Lisad: Erinevused valdkondade kasumlikkuses; 5 määravat konkurentsijõudu; Investeeritud kapitali keskmine tasuvus; Mõnede USA tegevusvaldkondade kasumlikkus; Valdkonnaanalüüs praktikas; Valdkonna määratlemine; Valdkonnaanalüüsi sammud

  14. Michael Polanyi (1891-1976): Medical Doctor, Chemist and a ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 23; Issue 1. Michael Polanyi (1891-1976): Medical Doctor, Chemist and a Philosopher. N Sathyamurthy. Article-in-a-Box Volume 23 Issue 1 January 2018 pp 11-14. Fulltext. Click here to view fulltext PDF. Permanent link:

  15. Correspondence of Michael Faraday, v.5 1855-1860

    CERN Document Server

    Faraday, Michael

    2008-01-01

    This volume includes 70% of previously unpublished letters of Michael Farday spanning half of the 1850s and most of 1860. Topics include Faraday's work on regelation, the transmission of light through gold and his appointment by Emperor Napoleon III to be a Commander of the Legion of Honour.

  16. Michael Pärt ئ suure muusika taustajõud / Michael Pärt ; interv. Siim Nestor

    Index Scriptorium Estoniae

    Pärt, Michael

    2008-01-01

    Arvo Pärdi pojast Michael Pärdist. Tema tööst "music editor"-ina - helimonteerijana, tööst muusika produktsiooni, salvestamise ja muusika kirjutamise abijõuna. Koostööst maailmas tuntud muusikutega

  17. High Blood Cholesterol Q&A Dr. Michael Lauer | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... High Cholesterol High Blood Cholesterol Q&A with Dr. Michael Lauer Past Issues / Summer 2012 Table of ... Recently, he discussed progress on high cholesterol research. Dr. Michael Lauer and his wife, Dr. Robin Avery, ...

  18. Tribute to Professor Anthony J. McMichael

    Directory of Open Access Journals (Sweden)

    Ashwin Swaminathan

    2014-11-01

    Full Text Available Emeritus Professor A. J. “Tony” McMichael (1942–2014 was an internationally renowned and pioneering Australian academic and advocate in epidemiology, who was passionate about understanding the influences of the environment on human health. In an illustrious career spanning more than four decades, he made significant contributions to the scientific community and policy discourse—including ground-breaking research related to the health of children. McMichael was a prolific academic writer with over 300 peer-reviewed papers; 160 book chapters and two sole-authored books. However, his outstanding talent was for integrating complex and seemingly unrelated strands from the environmental and health sciences into a cohesive narrative—and highlighting its relevance to lay persons, scientists and governments alike. He was instrumental in validating this nascent field of research and inspiring many others to follow his lead.

  19. Pengaruh Tipografi pada Era Massimo Vignelli terhadap Tipografi Michael Bierut

    Directory of Open Access Journals (Sweden)

    Irwan Harnoko

    2011-10-01

    Full Text Available Massimo Vignelli is a senior graphic designer lived in New York, as a vocal modernism against post-modernism. His statement firmly opposing post-modernism in several occasions: interview in Helvetica the movie, typeradio, talkshow, and some articles in Looking Closer or AIGA Journal. Graphic design works of Massimo Vignelli reflected his characteristic, which is firmly choosing typeface. Typefaces of Vignelly are around 5 typefaces: Bodoni, Helvetica, Times Roman, Century, and Futura. The article uses formal analysis method. The writers collected materials about Michael Bierut, Massimo VIgnelli and Tibor Kalman from books and websites. The writers compare the typeface opinion of Massimo Vignelli (modernism designer, Michael Bierut designer (transition era designer from modernism to post-modernism, and Tibor Kalman (a designer in A Century of Graphic Design, as the influencer of Bierut’s betrayal over Vignelli. 

  20. Euroopa parimaks filmiks sai Michael Haneke "Valge lint" / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2009-01-01

    Euroopa Filmiakadeemia auhindadest: parima filmiauhinna sai Saksamaal Bochumis toimunud tseremoonial Michael Haneke "Valge lint", mille eest Haneke sai ka parima režissööri ja stsenaristi auhinna. Parimaks meesnäitlejaks pärjati Tahar Rahim ("Un Prophete"), parimaks naisnäitlejaks Kate Winslet ("The Reader"), publikupreemia sai Danny Boyle'i "Rentslimiljonär. Ka teistest võitjatest

  1. Solvent-free microwave-mediated Michael addition reactions

    Indian Academy of Sciences (India)

    Unknown

    “green chemistry”, a reaction should ideally, be con- ducted under solvent-free conditions with minimal or no side-product formation and with utmost atom- economy.10 Even though microwave-assisted sol- vent-free Michael addition reactions on BiCl3 or CdI2,11. EuCl3,12 CeCl3.5H2O,13 and alumina14 surfaces are.

  2. Ajalooliste võrdluste eetika / Michael Rothberg ; intervjueerinud Eneken Laanes

    Index Scriptorium Estoniae

    Rothberg, Michael

    2017-01-01

    Intervjuu Tallinna ülikooli külastava kultuurimälu uurija, California ülikooli professori Michael Rothbergiga. Ta on sümpoosioni "Kultuurideülesed mäluvormid: sõja, ümberasumise ja poliitiliste konfliktide mäletamine nüüdisajal" peaesineja ja peab loengu "Pärandi probleem: migratsioon ja kultuurideülene holokausti mälu nüüdisaegsel Saksamaal". Ka tema raamatutest

  3. Hechter Michael, Horne Christine (Dir., Theories of Social Order

    Directory of Open Access Journals (Sweden)

    Yves Laberge

    2011-09-01

    Full Text Available Cette anthologie méconnue examine le concept fondamental de l’ordre social en 34 textes tantôt anciens (de Tocqueville, Marx, Engels, Simmel ou relativement récents (le chapitre 19 comparant les groupes humains aux fourmis date de 2007. Ici, l’ordre social est compris de diverses manières ; Michael Hechter et Christine Horne rappellent d’emblée que « sans ordre social, il ne peut y avoir ni agriculture, ni industrie, ni commerce, ni investissement, ni développement économique, ni justice, n...

  4. Michael Bull, Sound Moves. Ipod Culture and Urban Experience

    OpenAIRE

    Lisa McCormick

    2013-01-01

    Sound Moves, ouvrage non traduit de l'universitaire britannique Michael Bull, paru en 2007, a une place importante dans l'élaboration du champ de recherche sur l'écoute et les pratiques musicales appareillées en situation. Dans la continuité de son premier ouvrage (2000), ce deuxième opus poursuit l'étude de la « musicalisation » de notre quotidien au travers d’appareils mobiles, l'iPod en particulier. Dans la filiation d'un cadre théorique hérité des cultural studies et situé au carrefour de...

  5. El experimento de Milgram en Experimenter (2015) de Michael Almereyda

    OpenAIRE

    Díaz Boada, S.; Ramírez Salazar, M.

    2016-01-01

    La cinta cinematográfica del director estadounidense Michael Almereyda, Experimenter (2015), nos brinda un paseo por la vida del famoso y polémico psicólogo social Stanley Milgram. Este científico, de origen judío, diseñó a principios de los años 60’s una serie de experimentos en la Universidad de Yale, cuyos resultados fueron publicados bajo el título Behavioral Study of Obedience los cuales son conocidos como «El experimento de Milgram». Popularizado años después en su libro Obedience to au...

  6. The Correspondence of Michael Faraday Pt 6 1860-1867

    CERN Document Server

    Frank, James

    2012-01-01

    Michael Faraday (1791-1867) was one of the most important men of science in nineteenth century Britain. His discoveries of electro-magnetic rotations (1821) and electro-magnetic induction (1831) laid the foundations of the modern electrical industry. His discovery of the magneto-optical effect and diamagnetism (1845) led him to formulate the field theory of electro-magnetism, which forms one of the cornerstones of modern physics.These and a whole host of other fundamental discoveries in physics and chemistry, together with his lecturing at the Royal Institution, his work for the state (includi

  7. Michael Marinov memorial volume multiple facets of quantization and supersymmetry

    CERN Document Server

    Vainshtein, A I

    2002-01-01

    This book is dedicated to the memory of Michael Marinov, the theorist who, together with Felix Berezin, introduced the classical description of spin by anticommuting Grassmann variables. It contains original papers and reviews by physicists and mathematicians written specifically for the book. These articles reflect the current status and recent developments in the areas of Marinov's research: quantum tunneling, quantization of constrained systems, supersymmetry, and others. The personal recollections included portray the human face of M Marinov, a person of great knowledge and integrity.

  8. Investigation and Demonstration of Catalyst/Initiator-Driven Selectivity in Thiol-Michael Reactions.

    Science.gov (United States)

    Frayne, Stephen H; Murthy, Raghavendra R; Northrop, Brian H

    2017-08-04

    Thiol-Michael "click" reactions are essential synthetic tools in the preparation of various materials including polymers, dendrimers, and other macromolecules. Despite increasing efforts to apply thiol-Michael chemistry in a controlled fashion, the selectivity of base- or nucleophile-promoted thiol-Michael reactions in complex mixtures of multiple thiols and/or acceptors remains largely unknown. Herein, we report a thorough fundamental study of the selectivity of thiol-Michael reactions through a series of 270 ternary reactions using 1 H NMR spectroscopy to quantify product selectivity. The varying influences of different catalysts/initiators are explored using ternary reactions between two Michael acceptors and a single thiol or between a single Michael acceptor and two thiols using three different catalysts/initiators (triethylamine, DBU, and dimethylphenylphosphine) in chloroform. The results from the ternary reactions provide a platform from which sequential quaternary, one-pot quaternary, and sequential senary thiol-Michael reactions were designed and their selectivities quantified. These results provide insights into the design of selective thiol-Michael reactions that can be used for the synthesis and functionalization of multicomponent polymers and further informs how catalyst/initiator choice influences the reactivity between a given thiol and Michael acceptor.

  9. El fetiche etnográfico de Michael Taussig

    OpenAIRE

    Matthew Carlin

    2014-01-01

    El antropólogo Michael Taussig ha producido una gran cantidad de trabajo etnográfico sobre América Latina en el que toma por objeto la universalidad de la cultura burguesa y en el que, al reorientar la mirada del etnógrafo hacia los elementos embriagantes y orgiásticos de la vida, atenúa las líneas que dividen ciencia y arte. En este ensayo tengo la intención de mostrar lo siguiente: 1) que sus etnografías sobre magia, violencia y el Es-tado, están enraizadas en su priorización del mundo feno...

  10. Michael Longley’s Father: Memory, Mourning and History

    Directory of Open Access Journals (Sweden)

    Barry Sloan

    2012-03-01

    Full Text Available Michael Longley’s father has been a recurring presence in the poet’s work from his earliest to his most recent collection. This paper examines the exceptional strength of that bond reflected in the varied and changing ways in which the poet has responded to it – memorizing and mourning his loss; discovering through his father’s First World War stories a means of memorialising loss of life in contemporary conflicts and a way of facing the history of the twentieth century; confronting his own ageing and sense of mortality; and marking the specific, but also representative, generational history of his family. Close readings of key poems are offered to highlight Longley’s skills in meeting his own exacting standards of aesthetic propriety and moral and social responsibility for writers of elegy in order to avoid either exploitation of tragedy and loss, or facile gestures of consolation.

  11. Profiles in medical courage: Michael Wilkins and the Willowbrook School

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2012-03-01

    Full Text Available No abstract available. Article truncated at 150 words. “Never doubt that a small group of thoughtful, committed citizens can change the world. Indeed, it is the only thing that ever has. "- Margaret Mead With this article we begin an intermittent series on physicians who displayed courage in trying to help their patients. Although there are many examples, hopefully what will be illustrated are examples of the lesser known doctors who identified problems and stood up to address them. Few remember the controversy surrounding the now closed Willowbrook School and Dr. Michael Wilkins’ involvement. However, Wilkins’ courage in advocating for change not only resulted in substantial improvement in conditions at the school but also led to the Civil Rights of Institutionalized Persons Act (CRIPA of 1980.Wilkins was originally from Kansas City and graduated from the University of Missouri School of Medicine in 1967 (1. He left Missouri to do his pediatric internship and complete his military obligation…

  12. Expedition 8 Crew Interviews: C. Michael Foale - CDR

    Science.gov (United States)

    2003-01-01

    C. Michael Foale, Commander of the Expedition 8 crew to the International Space Station (ISS), answers interview questions in this video. The questions cover: 1) The goals of the Expedition; 2) How his Mir experience prepared him for long-duration spaceflight; 3) The reaction the Columbia accident where he was training in Star City, Russia; 4) Why the rewards of spaceflight are worth the risks; 5) Why he wanted to become an astronaut; 6) His career path; 7) His influences; 8) His path of study; 9) His responsibilities on a mission; 10) What a Soyuz capsule is like; 11) What the oncoming and offgoing ISS crews will do together; 12) How the ISS science mission will be advanced during his stay; 13) Training and plans for extravehicular activity (EVA); 14) Return to Flight of Shuttle; 15) What is needed to make his mission a success; 16) The most valuable contribution of the ISS.

  13. Energieffektivering av skolfartyget M/S Michael Sars

    OpenAIRE

    Ekebom Oscar, Lindholm Andreas

    2017-01-01

    Syftet med detta examensarbete är att undersöka och utvärdera hur värmeförbrukningen ombord på skolfartyget M/S Michael Sars kan effektiveras. Vi genomförde detta på tre olika sätt. Det första var att undersöka hur en isolering av maskinrummet och dess trapphus kan sänka uppvärmningsbehovet. Vi beräknade värmegenomgången genom skrovet samt hur mycket isoleringsmaterial som behövs. Det andra alternativet för energieffektivering är att undersöka hur ett eventuellt byte av fartygets oljeeldade p...

  14. Political Cinema and Culture industry: the work of Michael Moore

    Directory of Open Access Journals (Sweden)

    Cristiane Toledo Maria

    2015-03-01

    Full Text Available This article aims to reflect upon the production of the American filmmaker Michael Moore, proposing as a central question the relationship established between art and politics in a historical moment which, on one side, points to the crisis of capitalism and, on the other side, to the political fragmentation of the working class. Focusing on the analysis of the documentaries Roger & Me (1989 and Capitalism: a love story (2009, this article is an attempt to understand the method developed by the filmmaker to deal with the crisis of representation and communication experienced by political art in the last decades, as well as the conditions of representation of class struggle in American culture industry.

  15. Michael Heizer et les risques du sublime technologique

    OpenAIRE

    Paul, Serge

    2014-01-01

    Dans le désert du Nevada, Michael Heizer travaille depuis 40 ans à la réalisation de City, une sculpture de terre monumentale inspirée d’architectures précolombiennes. Sa pratique interventionniste nécessite des moyens industriels. En 2004, le gouvernement Bush a programmé la construction d’une voie ferrée passant à deux pas de City. Tous les déchets nucléaires des États-Unis convergeraient vers un unique site d’enfouissement de la région. Cette situation a-t-elle modifié la conscience écolog...

  16. Michael E. Lamb: Award for Distinguished Scientific Applications of Psychology.

    Science.gov (United States)

    2015-11-01

    The APA Award for Distinguished Scientific Applications of Psychology is presented to a person who, in the opinion of the Committee on Scientific Awards, has made distinguished theoretical or empirical advances leading to the understanding or amelioration of important practical problems. The 2015 recipient is Michael E. Lamb, who "has significantly advanced understanding of the developmental and contextual factors affecting the delivery and impact of child care in the early years of life; the role of parent-child relationships in development; and the cognitive, emotional, and social factors affecting the quality of children's testimony, especially in cases of sexual and physical abuse." award citation, biography, and a selected bibliography are presented here. (c) 2015 APA, all rights reserved).

  17. Estratégia competitiva: Michael Porter 30 anos depois

    Directory of Open Access Journals (Sweden)

    Manuel Portugal Ferreira

    2009-12-01

    Full Text Available Os estudos de estratégia têm sido muito influenciados pelos trabalhos de Michael Porter, em todas as suas fases, como as cinco forças, as estratégias genéricas, a cadeia de valor e as vantagens competitivas das nações. Neste artigo, analisou-se a influência de Porter nos trabalhos brasileiros em estratégia, a partir dos trabalhos selecionados e apresentados no EnANPAD. No levantamento para a análise dos artigos, considerando 10 anos de EnANPAD (1997-2006, foram selecionados 46 artigos. A identificação e seleção dos artigos envolveram os seguintes critérios: busca complementar por palavra-chave Porter na base de dados do EnANPAD; avaliação dos títulos e resumos dos artigos apresentados na área de estratégia entre 1997 e 2006, bem como na íntegra quando necessário. Procedeu-se também à análise das referências utilizadas nos artigos e o posicionamento dos autores em relação às tipologias de Porter. Como resultado, verificou-se que Michael Porter é um autor com grande influência nas pesquisas acadêmicas de estratégia. Seus estudos mais utilizados são os da análise da indústria e das estratégias genéricas, e também se verificou que a maioria dos estudos analisados é favorável aos seus conceitos, mesmo existindo pesquisas contrárias.

  18. A simple protocol for the michael addition of indoles with electron ...

    Indian Academy of Sciences (India)

    Administrator

    Abstract. Tetrabutylammonium hydrogen sulfate catalysed addition of indoles to electron deficient ole- fins in water generated the corresponding Michael adducts in good to excellent yield. The Michael addi- tion of indole occurred regioselectively at position 3 and the N-alkylated products have not been observed.

  19. A simple protocol for the michael addition of indoles with electron ...

    Indian Academy of Sciences (India)

    Tetrabutylammonium hydrogen sulfate catalysed addition of indoles to electron deficient olefins in water generated the corresponding Michael adducts in good to excellent yield. The Michael addition of indole occurred regioselectively at position 3 and the -alkylated products have not been observed. The synthesized ...

  20. A Musical Italy: Michael W. Balfe’s Italian Experiences

    Directory of Open Access Journals (Sweden)

    Basil Walsh

    2016-06-01

    Full Text Available The Dublin-born musician, Michael W. Balfe, was a singer, composerand conductor whose brilliant musical career was heavily influenced byformative experiences in Italy. In 1825, Balfe, interested in broadeninghis musical studies first went to Paris where he was introduced to thegreat composers, Luigi Cherubini and Gioachino Rossini, who took apersonal interest in him and his musical talents. On the advice of Rossinihe spent the next few years in Italy studying singing with the famousRossini singer, Filippo Galli, and taking music composition lessonsfrom Ferdinando Paer, in Rome. Later in Milan he studied harmonyand counterpoint with Vincenzo Federici. By 1831, when he was only23 years old, his first three operas had been produced in Palermo, Pavia,and Milan. He returned to London in August 1835, participatingwith the great Lablache, Tamburini, Rubini and Grisi in a concert inVauxhall Gardens. In 1834 he made his debut at La Scala, Milan, singingopposite the renowned mezzo-soprano, Maria Malibran in Rossini’sOtello. He appeared again with Malibran in Venice early in 1835,singing once more in Rossini and Bellini operas. Balfe worked as a singerand composer throughout the Italian peninsula/states during the years,1825-1835 and this article will chart these experiences and demonstratehow the time he spent in Italy and the people he met, influenced hislife and later career as an important and popular European composer.

  1. El fetiche etnográfico de Michael Taussig

    Directory of Open Access Journals (Sweden)

    Matthew Carlin

    2014-01-01

    Full Text Available El antropólogo Michael Taussig ha producido una gran cantidad de trabajo etnográfico sobre América Latina en el que toma por objeto la universalidad de la cultura burguesa y en el que, al reorientar la mirada del etnógrafo hacia los elementos embriagantes y orgiásticos de la vida, atenúa las líneas que dividen ciencia y arte. En este ensayo tengo la intención de mostrar lo siguiente: 1 que sus etnografías sobre magia, violencia y el Es-tado, están enraizadas en su priorización del mundo fenomenológico y en una concepción materialista en deuda con la teoría estética alemana del si-glo XIX y con la antropología especulativa de Karl Marx y Walter Benjamin; 2 que su proyecto etnográfico no consiste en la eliminación de la ciencia del ámbito de la etnografía, sino en disminuir el papel de la explicación en favor de una forma de escritura que, como el arte, trabaja para refundar las imágenes del mundo.

  2. Michael Field’s “A Dance of Death”

    Directory of Open Access Journals (Sweden)

    LeeAnne Richardson

    2012-03-01

    Full Text Available The 1912 poem "A Dance of Death" by Michael Field (pen name of Katherine Bradley and her niece Edith Cooper depicts Salome in an alternate version of the biblical story: this Salome dances on a frozen river, falls through the ice, and is decapitated on a jagged edge. Nonetheless, her beautiful head continues dancing over the frozen river. This poem is highly unusual, especially in the context of the other poems in the postconversion volume Poems of Adoration, because it questions, rather than submits to, authority. In re-writing a familiar Christian tale, as well as a familiar decadent theme, Field uses the poem to assert the supremacy of their artistic vision, which (despite their ardent Catholicism cannot be subject to any law outside themselves. Like the continually dancing head of Salome, which continues to create beauty even after nature (and perhaps God has struck it down, the poet is subjugate only to her own law and creates without boundaries or restrictions on her art. Bradley and Cooper were acutely aware of their authorial persona (actively taking not only a masculine but also a singular poetic identity, and their mode of reconciling the apparent contradictions of this identity are mirrored in their presentation of Salome in a "Dance of Death."

  3. 75 FR 62635 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Science.gov (United States)

    2010-10-12

    ... AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program... needed to determine patients' satisfaction with services provided by or through the Michael E. DeBakey.... Title: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10-0476. OMB Control...

  4. El espejo roto (I): Michael Lôwy y los cristianismos liberacionistas latinoamericanos

    OpenAIRE

    Pimentel Chacón, Jonathan

    2008-01-01

    El artículo discute la valoración de Michael Lôwy sobre la relaciónentre modernidad y teologías latinoamericanas de la liberación.Afirmo que este autor comprende inadecuadamente estas teologías y que sus comentarios poseen un valor explicativo reducido.Palabras claveTeologías latinoamericanas de la liberación, modernidad, religión, política, Michael Lôwy. AbstractThis article discusses the opinions of Michael Lôwy over therelationship between modernity and Latin American LiberationTheologies....

  5. Tõsine fotoelamus Dubrovnikus / Wade Goddard, Heidi Levine, Michael Robinson Chaver ; interv. Ahto Külvet

    Index Scriptorium Estoniae

    Goddard, Wade

    2007-01-01

    Dubrovniku vanalinnas asub Sõjafotokeskus. Intervjuu keskuse asutaja, kanadalasest fotograafi Wade Goddardi ja kahe seal augustis avatud näitusel osalenud fotograafi Heidi Levine'i ja Michael Robinson Chavez'iga. Sõjafotograafi tööst

  6. Theory and practice in action: the contributions of Michael Perkins to clinical linguistics.

    Science.gov (United States)

    Damico, Jack S; Lynch, Karen E

    2013-01-01

    This article reviews the scholarly contributions of Michael R. Perkins in the discipline of clinical linguistics and provides some indication of the reasons that he has been so successful. Three primary attributes were described through an analysis of his publications.

  7. Michael Fullan's Compelling Vision of Educational Change: Cultivating Meaningful Relationships for All.

    Science.gov (United States)

    Baker, Paul J.

    2001-01-01

    Essay review of the third edition (2001) of Michael Fullan's book "The Meaning of Educational Change." Discusses Fullan's educational change issues and concepts such as multiple meanings and consequent complexities and cultivating meaningful relationships. (Contains 28 references.) (PKP)

  8. Chiral Aminophosphines as Catalysts for Enantioselective Double-Michael Indoline Syntheses

    Directory of Open Access Journals (Sweden)

    Ohyun Kwon

    2012-05-01

    Full Text Available The bisphosphine-catalyzed double-Michael addition of dinucleophiles to electron-deficient acetylenes is an efficient process for the synthesis of many nitrogen-containing heterocycles. Because the resulting heterocycles contain at least one stereogenic center, this double-Michael reaction would be even more useful if an asymmetric variant of the reaction were to be developed. Aminophosphines can also facilitate the double-Michael reaction and chiral amines are more readily available in Nature and synthetically; therefore, in this study we prepared several new chiral aminophosphines. When employed in the asymmetric double-Michael reaction between ortho-tosylamidophenyl malonate and 3-butyn-2-one, the chiral aminophosphines produced indolines in excellent yields with moderate asymmetric induction.

  9. Eesti disain on kõva, ent see tuleb moondada ekspordiks / Michael Thomson ; interv. Urmas Oja

    Index Scriptorium Estoniae

    Thomson, Michael

    2008-01-01

    Euroopa Disainiassotsiatsioonide Liidu presidendi ja Tallinnas toimunud festivali Disainiöö Eesti disainiauhinna Bruno žürii juhi Michael Thomsoni arvamus eesti disainist ning disainipoliitika vajalikkusest Eestis. Auhinnasaajate nimekiri

  10. Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.

    Science.gov (United States)

    Krishnan, Shyam; Miller, Rand M; Tian, Boxue; Mullins, R Dyche; Jacobson, Matthew P; Taunton, Jack

    2014-09-10

    Electrophilic probes that covalently modify a cysteine thiol often show enhanced pharmacological potency and selectivity. Although reversible Michael acceptors have been reported, the structural requirements for reversibility are poorly understood. Here, we report a novel class of acrylonitrile-based Michael acceptors, activated by aryl or heteroaryl electron-withdrawing groups. We demonstrate that thiol adducts of these acrylonitriles undergo β-elimination at rates that span more than 3 orders of magnitude. These rates correlate inversely with the computed proton affinity of the corresponding carbanions, enabling the intrinsic reversibility of the thiol-Michael reaction to be tuned in a predictable manner. We apply these principles to the design of new reversible covalent kinase inhibitors with improved properties. A cocrystal structure of one such inhibitor reveals specific noncovalent interactions between the 1,2,4-triazole activating group and the kinase. Our experimental and computational study enables the design of new Michael acceptors, expanding the palette of reversible, cysteine-targeted electrophiles.

  11. Prints Charles ja prints Michael külastasid Tallinna kirikuid / Allan Tammiku

    Index Scriptorium Estoniae

    Tammiku, Allan

    2001-01-01

    Prints Charles külastas 6. novembril Eesti-visiidi ajal Tallinna toomkirikut ja Pühavaimu kirikut, prints Michael viibis Tallinnas 11. novembril eravisiidil, ta külastas toomkirikut, Niguliste ja Pühavaimu kirikut

  12. A History of Experiences and Thinking Men. The History of Political Thought according to Michael Oakeshott

    National Research Council Canada - National Science Library

    Spartaco Pupo

    2014-01-01

    Michael Oakeshott conceives the history of European political thought as a structuring of ideas and arguments of the practical experience aimed to understanding political expressions in vogue in the culture of a people...

  13. Dr. Michael DeBakey "is a magician of the heart…"

    Science.gov (United States)

    ... Bar Home Current Issue Past Issues Then & Now Dr. Michael DeBakey "is a magician of the heart…" ... version of this page please turn Javascript on. Dr. DeBakey with NLM's David Nash and admiring students ...

  14. Reports of the working groups / Eino Tamm, Sahlin Michael, Valve Kirsipuu...[jt.

    Index Scriptorium Estoniae

    1999-01-01

    Töögruppide "EU enlargement and relevant institutional reforms" (juhatajad Eino Tamm, Michael Sahlin) ja "Maintaining of competitiveness of Estonia and other candidate countries" (juhatajad Valve Kirsipuu, Terry Calbom) tööst. Autor: Reformierakond

  15. An Analysis Of Implicature In ‘The Neverending Story’ A Film Script By Michael Ende

    OpenAIRE

    Fadilah, Riskah

    2012-01-01

    Skripsi ini berjudul an analysis of implicature in ‘The Neverending Story’ a film script by Michael Ende. Skripsi ini menganalisis defenisi dan jenis-jenis implikatur serta mengetahui apakah makna sebenarnya yang terkandung dalam kalimat implikatur tersebut pada film “The Neverending Story” oleh Michael Ende. Skripsi ini membahas tentang jenis implikatur-implikatur yang muncul dari percakapan tokoh-tokoh yang ada dalam film ‘The Neverending Story’ dan juga menganalisis makna yang sebenarny...

  16. Michael-Stork addition of cyclopentyl enamine to allenyl ketones and esters.

    Science.gov (United States)

    Silvestri, Maximilian A; Bromfield, Deborah C; Lepore, Salvatore D

    2005-09-30

    [Chemical reaction: see text] We report the first examples of a Michael-Stork enamine addition to allenyl esters and ketones. Studies reveal that 2 equivalents of enamine are required for optimal yields. In the case of an allenyl methyl ketone, cyclopentyl enamine addition led to 8-oxobicyclo[3.2.1]octane formation, providing evidence for the in situ formation of an enamine intermediate following the initial Michael-Stork reaction.

  17. A post-Byzantine creation: The archangel Michael triumphant and psychopomp

    Directory of Open Access Journals (Sweden)

    Leontakianakou Irini

    2009-01-01

    Full Text Available This paper deals with a specific iconographic type of Archangel Michael: he is shown bearing a soul in the form of a swaddled infant, while subduing an old man who is wearing only a loincloth. Who is Michael subduing? Three possible answers are considered: 1 the figure can be identified with Satan the fallen angel who, like Michael, has an immaterial nature and is commonly considered as his enemy par excellence; 2 he can also be an anonymous sinner, whose soul is depicted in Michael's hand; 3 finally, one could identify him with Hades, the god of the Underworld and personification of death, because he is depicted as an old man, semi-nude with a pronounced musculature, as well as because of the assimilation of Michael to God. Rather than making a single choice, the author proposes a combined interpretation of the image, which allows for the integration of all the aspects of Michael's cult (military, triumph over Satan, psychopomp, archangel of the Last Judgment and unifies the past (the fall of Satan, the present (death of a sinner and the future (Last Judgment.

  18. Copper-catalyzed asymmetric conjugate addition of organometallic reagents to extended Michael acceptors

    Directory of Open Access Journals (Sweden)

    Thibault E. Schmid

    2015-12-01

    Full Text Available The copper-catalyzed asymmetric conjugate addition (ACA of nucleophiles onto polyenic Michael acceptors represents an attractive and powerful methodology for the synthesis of relevant chiral molecules, as it enables in a straightforward manner the sequential generation of two or more stereogenic centers. In the last decade, various chiral copper-based catalysts were evaluated in combination with different nucleophiles and Michael acceptors, and have unambiguously demonstrated their usefulness in the control of the regio- and enantioselectivity of the addition. The aim of this review is to report recent breakthroughs achieved in this challenging field.

  19. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions

    Directory of Open Access Journals (Sweden)

    Giovanna Bosica

    2016-06-01

    Full Text Available Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs.

  20. A Greener, Efficient Approach to Michael Addition of Barbituric Acid to Nitroalkene in Aqueous Diethylamine Medium

    Directory of Open Access Journals (Sweden)

    Hany J. Al-Najjar

    2014-01-01

    Full Text Available An efficient method for the synthesis of a variety of pyrimidine derivatives 3a–t by reaction of barbituric acids 1a,b as Michael donor with nitroalkenes 2a–k as Michael acceptor using an aqueous medium and diethylamine is described. This 1,4-addition strategy offers several advantages, such as using an economic and environmentally benign reaction media, high yields, versatility, and shorter reaction times. The synthesized compounds were identified by 1H-NMR, 13C-NMR, CHN, IR, and MS. The structure of compound 3a was further confirmed by single crystal X-ray structure determination.

  1. Gender Relations and Sexual Harassment in the Workplace: Michael Crichton's "Disclosure" as a Teaching Tool.

    Science.gov (United States)

    Comer, Debra R.; Cooper, Elizabeth A.

    1998-01-01

    Describes how to use Michael Crichton's novel "Disclosure" and the film based on it for class discussions of such issues as what constitutes sexual harassment, harassment of men, relationship between sexual harassment and power, organizational responses to harassment, and gender differences in career advancement tactics. (SK)

  2. Schools as "Poetry-Friendly Places": Michael Rosen on Poetry in the Curriculum

    Science.gov (United States)

    Xerri, Daniel

    2014-01-01

    This article explores the views of children's poet Michael Rosen in relation to poetry in education. It is based on an interview in which Rosen not only discusses the significance of encouraging young people to engage with poetry at school but also analyzes a number of threats to poetry's place in the English curriculum. This article identifies…

  3. European Management: an emerging competitive advantage of European nations : A reply to Michael Porter

    NARCIS (Netherlands)

    F.A.J. van den Bosch (Frans); A.A. van Prooijen

    1992-01-01

    textabstractThis article extends the debate begun in the June 1992 issue of EMJ when the authors first criticized Michael Porter's explanatory framework in his Competitive Advantage of Nations (1990), over the role of national culture on the competitive advantage of nations. In this paper, Frans van

  4. Organocatalytic asymmetric assembly reactions for the syntheses of carbohydrate derivatives by intermolecular Michael-Henry reactions

    Science.gov (United States)

    Uehara, Hisatoshi; Imashiro, Ritsuo; Hernández-Torres, Gloria; Barbas, Carlos F.

    2010-01-01

    Given the significance of carbohydrates in life, medicine, and industry, the development of simple and efficient de novo methods to synthesize carbohydrates are highly desirable. Organocatalytic asymmetric assembly reactions are powerful tools to rapidly construct molecules with stereochemical complexity from simple precursors. Here, we present a simple and robust methodology for the asymmetric synthesis of pyranose derivatives with talo- and manno- configurations from simple achiral precursors through organocatalytic asymmetric intermolecular Michael–Henry reaction sequences. In this process, (tert-butyldimethylsilyloxy)acetaldehyde 1 was successfully utilized in two ways: as a donor in a highly selective anti-Michael reaction and as an acceptor in a consecutive Henry reaction. Varied nitroolefins served as Michael acceptors and varied aldehydes substituted for 1 as Henry acceptors providing for the construction of a wide range of carbohydrates with up to 5 stereocenters. In these reactions, a catalyst-controlled Michael reaction followed by a substrate-controlled Henry reaction provided 3,4-dideoxytalose derivatives 6 in a highly stereoselective manner. The Henry reaction was affected by addition of a simple base such as triethylamine: A complex chiral base was not necessary. 3,4-Dideoxymannose derivatives 7 were produced by simply changing the base from triethylamine to 1,8-diazabicyclo[5.4.0]undec-7-ene. Extension of this methodology to a syn-Michael initiated sequence was also successful. A mechanistic discussion is provided to explain the unusual substrate-induced stereoselectivity of the Henry reaction. PMID:20639468

  5. Critical notice: Michael Tomasello on the “prosocial” human animal

    DEFF Research Database (Denmark)

    Larsen, Steen Nepper

    2014-01-01

    Abstract According to Michael Tomasello humans cannot help to be informative. Apes, like chimps, do not point at each other, only humans do so in order to attract attention, i.e. to (get) help, play and share experiences. In shared cooperative activities, individual rationality is transformed int...

  6. The power of virtual integration: an interview with Dell Computer's Michael Dell. Interview by Joan Magretta.

    Science.gov (United States)

    Dell, M

    1998-01-01

    Michael Dell started his computer company in 1984 with a simple business insight. He could bypass the dealer channel through which personal computers were then being sold and sell directly to customers, building products to order. Dell's direct model eliminated the dealer's markup and the risks associated with carrying large inventories of finished goods. In this interview, Michael Dell provides a detailed description of how his company is pushing that business model one step further, toward what he calls virtual integration. Dell is using technology and information to blur the traditional boundaries in the value chain between suppliers, manufacturers, and customers. The individual pieces of Dell's strategy--customer focus, supplier partnerships, mass customization, just-in-time manufacturing--may be all be familiar. But Michael Dell's business insight into how to combine them is highly innovative. Direct relationships with customers create valuable information, which in turn allows the company to coordinate its entire value chain back through manufacturing to product design. Dell describes how his company has come to achieve this tight coordination without the "drag effect" of ownership. Dell reaps the advantages of being vertically integrated without incurring the costs, all the while achieving the focus, agility, and speed of a virtual organization. As envisioned by Michael Dell, virtual integration may well become a new organizational model for the information age.

  7. Moral Education and Education in Altruism: Two Replies to Michael Hand

    Science.gov (United States)

    White, John

    2016-01-01

    This article is a critical discussion of two recent papers by Michael Hand on moral education. The first is his "Towards a Theory of Moral Education", published in the "Journal of Philosophy of Education" in 2014 (Volume 48, Issue 4). The second is a chapter called "Beyond Moral Education?" in an edited book of new…

  8. Book Review of "The Molecular Biology of Cancer" by Stella Pelengaris, Michael Khan (Editors

    Directory of Open Access Journals (Sweden)

    Schmidt Christian

    2007-11-01

    Full Text Available Abstract Here, a review of "The Molecular Biology of Cancer" (Stella Pelengaris and Michael Khan [Editors] is given. The detailed description of the book is provided here: Pelengaris S, Khan M (Eds: The Molecular Biology of Cancer; Blackwell Publishing, Oxford (U.K.; 2006. 531 pages, 214 illustrations, ISBN 9-78140-511-814-9, £31.99.

  9. SYNTHESIS OF SOME PROLINE DERIVATIVES BY MEANS OF MICHAEL ADDITIONS OF GLYCINE ESTERS

    NARCIS (Netherlands)

    VANDERWERF, A; KELLOGG, RM

    1991-01-01

    Addition of the Schiff bases derived from reaction of glycine alkyl esters with benzophenoneimine to alpha,beta-unsaturated ketones, followed by hydrogenation of the addition products, leads to 5- or 3,5-substituted prolines. Hydrolysis of the Michael adducts rather than hydrogenation allows

  10. Kunstlik viljastamine - kas rahva püsimajäämise võti? / Michael Cook

    Index Scriptorium Estoniae

    Cook, Michael

    2007-01-01

    Kunstlikust viljastamisest pole üksi abi - vaid siis, kui noored mehed ja naised pööravad selja tarbimiskultusele ja individualismile, hakkab sündimus tõusma taastootmisest kõrgemale, kirjutab BioEdge toimetaja Michael Cook

  11. Prolinethiol ether catalysis in an asymmetric Michael reaction: solvent-free synthesis of functionalized monohaloalkenes.

    Science.gov (United States)

    Xia, Ai-Bao; Wu, Chao; Xu, Dan-Qian; Wang, Yi-Feng; Du, Xiao-Hua; Li, Zhao-Bo; Xu, Zhen-Yuan

    2013-02-01

    The organocatalytic Michael reaction of ketones with γ-monohalonitrodienes catalyzed by chiral prolinethiol ether under solvent-free conditions was developed. The described method represents a novel approach for accessing highly functionalized monohaloalkenes with α, β-stereocenters of up to >99% ee.

  12. An Interview with Michael Horn: Blending Education for High-Octane Motivation

    Science.gov (United States)

    Patterson, Gregory A.

    2012-01-01

    Blended learning holds the potential of improving the way we educate students and of making them more motivated. Blended education--the melding of information technology based distance learning with school attendance--is perhaps the best way to educate students for 21st century skills, says Michael Horn in a "Kappan" interview. Horn points out…

  13. Outside in America: George Michael's music video, public sex and global pop culture

    NARCIS (Netherlands)

    Kooijman, J.

    2004-01-01

    Six months after his controversial arrest for ‘lewd conduct’ at a men’s public restroom in Beverly Hills, British pop star George Michael released the song and music video ‘Outside’ which can be seen as an explicit commentary on the controversy. In this article, I read the music video in three ways:

  14. Hexafluorobenzene: A powerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction

    KAUST Repository

    Lattanzi, Alessandra

    2012-01-01

    A dramatic enhancement of the diastereo- and enantioselectivity in the nitro-Michael addition reaction organocatalysed by a commercially available α,α-l-diaryl prolinol was disclosed when performing the reaction in unconventional hexafluorobenzene as a medium. DFT calculations were performed to clarify the origin of stereoselectivity and the role of C 6F 6. © The Royal Society of Chemistry 2012.

  15. Q & A with Ed Tech Leaders: Interview with Michael W. Allen

    Science.gov (United States)

    Shaughnessy, Michael F.

    2014-01-01

    Michael W. Allen, the Chairman and CEO of Allen Interactions, is an architect of interactive multimedia learning and is recognized for his many insights, inventions, and presentations. With over 50 years of experience in e-learning, both in academic and corporate settings, he is known for his role in creating Authorware and overseeing the work of…

  16. Phosphonium salts as chiral phase-transfer catalysts: asymmetric Michael and Mannich reactions of 3-aryloxindoles.

    Science.gov (United States)

    He, Rongjun; Ding, Changhua; Maruoka, Keiji

    2009-01-01

    It's a PTC: A highly efficient reaction of 3-aryloxindoles in an asymmetric Michael addition was achieved by using a quaternary tetraalkylphosphonium salt as a chiral phase-transfer catalyst (PTC). The products were obtained in quantitative yields high ee values. The reaction of 3-aryloxindoles in an asymmetric Mannich reaction using the same catalyst also proved to be feasible.

  17. Enantioselective Michael Addition of Malonates to Chalcone Derivatives Catalyzed by Dipeptide-derived Multifunctional Phosphonium Salts.

    Science.gov (United States)

    Cao, Dongdong; Fang, Guosheng; Zhang, Jiaxing; Wang, Hongyu; Zheng, Changwu; Zhao, Gang

    2016-10-21

    Highly enantioselective Michael addition of malonates to enones catalyzed by dipeptide-derived multifunctional phosphonium salts has been developed. The newly established catalytic system was characterized with its wide substrate scope featured with aliphatic aldehyde-derived enones and substituted malonates. The gram scale-up synthesis of adducts can also be successfully achieved under optimal conditions with both excellent yield and enantioselectivity.

  18. Why Do We Need a Philosophy of Education? The Forgotten Insights of Michael John Demiashkevich

    Science.gov (United States)

    Senechal, Diana

    2010-01-01

    For many decades, American schools have been mired in jargon and confused values. A few exceptional books have shown the way through the thicket of educational ideas, policies, and practices. The work of Michael John Demiashkevich belongs to this set and offers a special philosophical perspective. In "An Introduction to the Philosophy of…

  19. The Data on Children's Media Use: An Interview with Michael Robb

    Science.gov (United States)

    Heller, Rafael

    2018-01-01

    Since 2003, nonprofit organization Common Sense Media has studied the ways in which kids are growing up in the digital age. In this interview, research director Michael Robb shares recent findings about the media habits of young children, tweens, and teens. While the news coverage of these issues tends to be hyperbolic and alarming, Robb explains,…

  20. La epistemologia de Michael Polanyi: una perspectiva realista de la ciencia. [Reseña

    OpenAIRE

    Moros, E.

    2005-01-01

    Reseña de Francisco GALLARDO, La epistemologia de Michael Polanyi: una perspectiva realista de la ciencia, Edizioni Universita della Santa Croce («Series Philosophica »), Roma 2004, 347 pp., 17 x 24, ISBN 88-8333-131-1.

  1. Assessment of lipid profile of a group of undergraduates in Michael ...

    African Journals Online (AJOL)

    Objective: The aim of this study was to measure the lipid fractions in serum blood samples of apparently healthy undergraduates of Michael Okpara University of Agriculture, Umudike. Methods: A total of one hundred consenting males and females aged between 19-30 years were purposively selected from the ...

  2. Noted astrophysicist Michael S. Turner to Head NSF'S mathematical and physical sciences directorate

    CERN Multimedia

    2003-01-01

    "The National Science Foundation has named celebrated astrophysicist Michael S. Turner of the University of Chicago as Assistant Director for Mathematical and Physical Sciences. He will head a $1 billion directorate that supports research in mathematics, physics, chemistry, materials and astronomy, as well as multidisciplinary programs and education" (1/2 page).

  3. Wolff-Michael Roth's passibility: at the limits of the constructivist metaphor: a book review

    Science.gov (United States)

    Brendel, Michelle

    2014-12-01

    Wolff-Michael Roth deconstructs the preeminent role conceded to constructivism in Science Education and demonstrates how we learn and know through pain, suffering, love or passion. This review explores his book "Passibility: At the Limits of the Constructivist Metaphor" through the eyes of an outsider to the world of science education.

  4. Michael Faraday on the Learning of Science and Attitudes of Mind.

    Science.gov (United States)

    Crawford, Elspeth

    1998-01-01

    Makes use of Michael Faraday's ideas on learning, focusing on his attitudes toward the unknowns of science and the development of an attitude that improves scientific decision making. This approach acknowledges that there is an inner struggle involved in facing unknowns. (DDR)

  5. 77 FR 69550 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Science.gov (United States)

    2012-11-19

    ... AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program.... This notice solicits comments on information needed to determine patients' satisfaction with services... information technology. Title: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10...

  6. 76 FR 624 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Science.gov (United States)

    2011-01-05

    ... AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program.... 2900-New (VA Form 10-0476).'' SUPPLEMENTARY INFORMATION: Title: Patient Satisfaction Survey Michael E... Review: New collection. Abstract: VA Form 10-0476 will be used to gather feedback from patients regarding...

  7. 78 FR 6851 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Science.gov (United States)

    2013-01-31

    ... AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program....'' SUPPLEMENTARY INFORMATION: Title: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10.... Abstract: VA Form 10-0476 will be used to gather feedback from patients regarding their satisfaction with...

  8. Novel Ionic Liquid with Both Lewis and Brønsted Acid Sites for Michael Addition

    Directory of Open Access Journals (Sweden)

    Runpu Shen

    2011-10-01

    Full Text Available Ionic liquid with both Lewis and Brønsted acid sites has been synthesized and its catalytic activities for Michael addition were carefully studied. The novel ionic liquid was stable to water and could be used in aqueous solution. The molar ratio of the Lewis and Brønsted acid sites could be adjusted to match different reactions. The results showed that the novel ionic liquid was very efficient for Michael addition with good to excellent yields within several min. Operational simplicity, high stability to water and air, small amount used, low cost of the catalyst used, high yields, chemoselectivity, applicability to large-scale reactions and reusability are the key features of this methodology, which indicated that this novel ionic liquid also holds great potential for environmentally friendly processes.

  9. Production of Low-Freezing-Point Highly Branched Alkanes through Michael Addition.

    Science.gov (United States)

    Jing, Yaxuan; Xia, Qineng; Liu, Xiaohui; Wang, Yanqin

    2017-12-22

    A new approach for the production of low-freezing-point, high-quality fuels from lignocellulose-derived molecules was developed with Michael addition as the key step. Among the investigated catalysts, CoCl 2 ⋅6 H 2 O was found most active for the Michael addition of 2,4-pentanedione with FA (single aldol adduct of furfural and acetone, 4-(2-furanyl)-3-butene-2-one). Over CoCl 2 ⋅6 H 2 O, a high carbon yield of C 13 oxygenates (about 75 %) can be achieved under mild conditions (353 K, 20 h). After hydrodeoxygenation, low-freezing-point (freezing-point (freezing point from renewable biomass. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Michael-type addition of azoles of broad-scale acidity to methyl acrylate

    Directory of Open Access Journals (Sweden)

    Krzysztof Z. Walczak

    2011-02-01

    Full Text Available An optimisation of Michael-type addition of azole derivatives of broad-scale acidity – ranging from 5.20 to 15.00 pKa units – namely 4-nitropyrazole, 3,5-dimethyl-4-nitropyrazole, 4(5-nitroimidazole, 4,5-diphenylimidazole, 4,5-dicyanoimidazole, 2-methyl-4(5-nitroimidazole, 5(4-bromo-2-methyl-4(5-nitroimidazole and 3-nitro-1,2,4-triazole to methyl acrylate as an acceptor was carried out. The optimisation process involved the use of an appropriate basic catalyst (DBU, DIPEA, NaOH, NaH, TEDA, a donor/base/acceptor ratio and the reaction temperature. The reactions were performed in DMF as solvent. Target Michael adducts were obtained in medium to excellent yields. Importantly, for imidazole and 1,2,4-triazole derivatives, no corresponding regioisomers were obtained.

  11. Michael K. Scullin: Psi Chi/APA Edwin B. Newman Graduate Research Award.

    Science.gov (United States)

    2011-11-01

    Presents Michael K. Scullin as the 2011 winner of the American Psychological Association Psi Chi/APA Edwin B. Newman Graduate Research Award. "For an outstanding research paper that examines the relationship between prospective memory in executing a goal and various lapses of time from 20 minutes up to a 12- hour wake delay and a 12-hour sleep delay. The results suggest that consolidation processes active during sleep increase the probability of goal execution. The paper, titled 'Remembering to Execute a Goal: Sleep On It!' was published in Psychological Science in 2010 and was the basis for Michael K. Scullin's selection as the recipient of the 2011 Psi Chi/APA Edwin B. Newman Graduate Research Award. Mark A. McDaniel, PhD, served as faculty research advisor." (PsycINFO Database Record (c) 2011 APA, all rights reserved). 2011 APA, all rights reserved

  12. Navigating Transition: Freedom, Limitation and the Post-colonial Persona in Michael Ondaatje's The Cat's Table

    Directory of Open Access Journals (Sweden)

    Alaa Alghamdi

    2012-11-01

    Full Text Available Michael Ondaatje's 2011 novel The Cat's Table follows a young boy's voyage from Colombo, Sri Lanka to London, England. Through this character and the unique environment of the ship, which forms a compelling sense of transitory place, Ondaatje explores liminality and its relationship with limitations or barriers. The young protagonist, Michael, and his companions enjoy an unusual level of freedom aboard the contained and hierarchically segmented ship. Polarization and transition between Eastern and Western culture is present but pales in importance compared to the validation of the self that is located within and defined by the sense of the in-between, an essential rite of passage undertaken before re-joining society.

  13. Multicatalytic, asymmetric Michael/Stetter reaction of salicylaldehydes and activated alkynes

    Science.gov (United States)

    Filloux, Claire M.; Lathrop, Stephen P.; Rovis, Tomislav

    2010-01-01

    We report the development of a multicatalytic, one-pot, asymmetric Michael/Stetter reaction between salicylaldehydes and electron-deficient alkynes. The cascade proceeds via amine-mediated Michael addition followed by an N-heterocyclic carbene-promoted intramolecular Stetter reaction. A variety of salicylaldehydes, doubly activated alkynes, and terminal, electrophilic allenes participate in a one-step or two-step protocol to give a variety of benzofuranone products in moderate to good yields and good to excellent enantioselectivities. The origin of enantioselectivity in the reaction is also explored; E/Z geometry of the reaction intermediate as well as the presence of catalytic amounts of catechol additive are found to influence reaction enantioselectivity. PMID:20639467

  14. Organocatalyzed asymmetric Michael addition by an efficient bifunctional carbohydrate-thiourea hybrid with mechanistic DFT analysis.

    Science.gov (United States)

    Azad, Chandra S; Khan, Imran A; Narula, Anudeep K

    2016-12-28

    A series of thiourea based bifunctional organocatalysts having d-glucose as a core scaffold were synthesized and examined as catalysts for the asymmetric Michael addition reaction of aryl/alkyl trans-β-nitrostyrenes over cyclohexanone and other Michael donors having active methylene. Excellent enantioselectivities (<95%), diastereoselectivities (<99%), and yields (<99%) were attained under solvent free conditions using 10 mol% of 1d0. The obtained results were explained through DFT calculations using the B3LYP/6-311G(d,p)//B3LYP/6-31G(d) basic set. The QM/MM calculations revealed the role of cyclohexanone as a solvent as well as reactant in the rate determining step imparting 31.91 kcal mol(-1) of energy towards the product formation.

  15. Creative Industries, Value Theory and Michael Heinrich’s New Reading of Marx

    OpenAIRE

    Pitts, Frederick Harry

    2015-01-01

    This article utilises the new reading of Marx found in the work of Michael Heinrich to analyse the creative industries. It considers the role played in the production of value by the labour that takes place in the sphere of circulation. The specific focus is on creative industries such as graphic design, advertising, and branding. It applies Heinrich's conceptualisation of “social validation” to these sectors. This suggests that valorisation depends upon goods and services attaining commodity...

  16. Is Smaller Better? A Comment on "Comparative Economic Impact Analyses" by Michael Mondello and Patrick Rishe

    OpenAIRE

    Victor Matheson

    2004-01-01

    In a recent article in Economic Development Quarterly, "Comparative Economic Impact Analyses: Differences Across Cities, Events, and Demographics" (November 2004), Michael Mondello and Patrick Rishe examined the economic impact of small, amateur sporting events on host economies. This response to their work suggests four reasons why ex ante economic impact estimates for smaller sporting events may come closer to matching ex post reality than those for "mega-events" including less crowding out...

  17. Nitroxide polymer networks formed by Michael addition: on site-cured electrode-active organic coating.

    Science.gov (United States)

    Ibe, Takeshi; Frings, Rainer B; Lachowicz, Artur; Kyo, Soichi; Nishide, Hiroyuki

    2010-05-28

    Highly and homogeneously crosslinked poly(beta-ketoester) networks densely bearing robust nitroxide radicals were prepared via a click-type and stepwise Michael polyaddition. A half-battery cell composed of the thermally-cured radical network coatings displayed a rapid, reversible, and almost stoichiometric redox-activity even with a thickness of ca. 10 mum, which may be applicable as the electrode of organic-based rechargeable devices.

  18. Traces of the Unrepresentable in the Modernist Discourse of Clement Greenberg and Michael Fried

    OpenAIRE

    Gal, Nissim

    2013-01-01

    The present essay aims to remap the modernist writing of Clement Greenberg and his successor Michael Fried from the late 1930s to the 1960s. For many years these two critics/theorists were considered leaders of the American modernist camp that promoted the purity of the medium and the total dependence of reading art on the primacy of perception. Attentive reading of the canonical texts they authored will surprisingly reveal that between the theoretical lines of their writings dwells an essent...

  19. Feeding Health: Michael Pollan on Improving Public Health through the Food Systems

    Centers for Disease Control (CDC) Podcasts

    2009-08-19

    In this podcast, author Michael Pollan discusses his March 2009 visit to CDC and offers his thoughts on the intersection between the government, the food systems, and public health.  Created: 8/19/2009 by National Center for Environmental Health (NCEH), National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Office of Sustainability.   Date Released: 4/15/2010.

  20. Learned Helplessness Encountered by Michael Oher in the Blind Side Movie

    OpenAIRE

    PAMUNGKAS, DIMAS PROBO

    2014-01-01

    Pamungkas, Dimas Probo. 2014. Learned Helplessness Encountered by Michael Oher in The Blind Side Movie. Study Program of English, Department of Languages and Literature, Faculty of Culture Studies, Universitas Brawijaya. Supervisor: Dyah Eko Hapsari;Co-supervisor: Sarlettina Vidyayani EkaKeywords: Learned Helplessness, African-American, Psychological, Social Behavior, Depression, The Blind Side.Social behavior shows several interactions between person and social situations, which stress...

  1. Highlighting High Performance: Michael E. Capuano Early Childhood Center; Somerville, Massachusetts

    Energy Technology Data Exchange (ETDEWEB)

    2006-03-01

    This brochure describes the key high-performance building features of the Michael E. Capuano Early Childhood Center. The brochure was paid for by the Massachusetts Technology Collaborative as part of their Green Schools Initiative. High-performance features described are daylighting and energy-efficient lighting, indoor air quality, solar and wind energy, building envelope, heating and cooling systems, water conservation, and acoustics. Energy cost savings are also discussed.

  2. En memoria de Michael Jiménez (1948-2001

    Directory of Open Access Journals (Sweden)

    Mauricio Archila Neira

    2001-01-01

    Full Text Available El 1 de septiembre de 2001 murió el historiador Michael Jiménez. Su apellido provenía de España de donde emigró su abuelo en busca de mejor suerte al otro lado del Atlántico. Nacido en el pequeño pueblo de Merced, California (Estados Unidos en agosto de 1948 en el seno de una familia obrera, Michael vivió su infancia en Colombia. A fines de ese año, su padre se desplazó a estas tierras para ser funcionario de la Texas, una multinacional petrolera que tenía sus reales en Puerto Boyacá. Michael estudió en el colegio Nueva Granada -becado por la Texas- hasta los catorce años. En dicho colegio fue compañero de pupitre de Herbert Braun, descendiente a su vez de una familia de emigrantes a Colombia, y con quien la vida lo juntaría de nuevo en las tierras del norte y en oficios similares.

  3. A perspectiva de Michael Apple para os estudos das políticas educacionais

    Directory of Open Access Journals (Sweden)

    Luís Armando Gandin

    Full Text Available Resumo Este artigo tem como objetivo analisar as contribuições de Michael Apple para o campo da pesquisa em políticas educacionais. Na extensa obra de Michael Apple, destacamos seis elementos que podem auxiliar aqueles que estão interessados na área de políticas em educação: o princípio epistemológico da análise relacional; o exame do Estado como relação; a herança de Antonio Gramsci e de Raymond Williams que Michael Apple incorpora no uso de conceitos como hegemonia e senso comum; a análise que Michael Apple faz das políticas educacionais como políticas culturais, como disputas por visão de mundo, como luta por consolidação de uma hegemonia que vai além do econômico; a sua postura de pesquisador; e a capacidade que Michael Apple tem de ir além da lógica da reprodução e determinação para enfatizar o papel da agência e da contra-hegemonia. Através de exemplos práticos da própria obra de Apple e de outras pesquisas empíricas, apresentam-se as implicações de cada um dos seis pontos acima citados para os pesquisadores interessados na área de políticas educacionais. Conclui-se que muitas das contribuições de Apple podem auxiliar em pesquisas nessa área, tendo em vista a discussão que o autor realiza em sua obra e sua crítica ao determinismo econômico nas análises do campo educacional, salientando a importância, assim, de aspectos que estão relacionados à esfera da cultura.

  4. The big picture : What the Baltics may learn from Ireland's success story / Michael Bourke ; interv. Maris Biezaitis

    Index Scriptorium Estoniae

    Bourke, Michael

    2002-01-01

    Ilmunud ka: Baltiiskii kurss 2002/Zima/Vesna nr. 20 lk. 14-17. Iirimaa aukonsul Lätis, Michael Joseph Bourke arutleb Iirimaa majandusedu teemal ning pakub välja, mida Baltimaad saaksid sellest õppida. Tabel, diagramm. Lisa

  5. Tagasipöördumine esteetika juurde = Return to aesthetics / Keith Moxey, Michael Ann Holly ; interv. Anu Allas

    Index Scriptorium Estoniae

    Moxey, Keith

    2007-01-01

    Ameerika kunstiajaloolased Keith Moxey ning Michael Ann Holly tutvustavad uut lähenemist kunstiajaloole (new art history). Nn. naasmine esteetika juurde tähendab püüet integreerida kunstiajalukku ja -teooriasse uuesti ja tugevamalt kunstiteos

  6. Asymmetric Michael-aldol tandem reaction of 2-substituted benzofuran-3-ones and enones: a facile synthesis of griseofulvin analogues.

    Science.gov (United States)

    Dong, Nan; Li, Xin; Wang, Feng; Cheng, Jin-Pei

    2013-09-20

    A highly enantioselective Michael-aldol tandem reaction with respect to prochiral 2-substituted benzofuran-3-ones and enones by a facile primary amine catalyst was investigated. The approach provides rapid access to the desired pharmaceutically active griseofulvin analogues.

  7. One-Pot Synthesis of Esters of Cyclopropane Carboxylic Acids via Tandem Vicarious Nucleophilic Substitution-Michael Addition Process.

    Science.gov (United States)

    Mąkosza, Mieczysław; Bester, Karol; Cmoch, Piotr

    2015-06-05

    α-Chlorocarbanions generated via base-induced vicarious nucleophilic substitution reaction of alkyl dichloroacetates with nitroarenes react with Michael acceptors to give esters of cyclopropane carboxylic acids substituted with p-nitroaromatic rings.

  8. Michael T. Westrate. Living Soviet in Ukraine from Stalin to Maidan: Under the Falling Red Star in Kharkiv.

    Directory of Open Access Journals (Sweden)

    Charitie V. Hyman

    2017-09-01

    Full Text Available Book review of Michael T. Westrate. Living Soviet in Ukraine from Stalin to Maidan: Under the Falling Red Star in Kharkiv. Rowman & Littlefield, 2016. xx, 232 pp. Illustrations. Appendices. Bibliography. Index. $85.00, cloth.

  9. Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology

    DEFF Research Database (Denmark)

    Pors, Niels Ole

    2010-01-01

    Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology. Medford. Information Today. ASIS&T Monographs, 2009. 185 pages. $ 59.50. ISBN 978-1-57387-373-4......Review: Michael Crandall & Karen E. Fisher (Eds) Digital Inclusion: Measuring the Impact of Information and Community Technology. Medford. Information Today. ASIS&T Monographs, 2009. 185 pages. $ 59.50. ISBN 978-1-57387-373-4...

  10. Rh(III)-Catalyzed C-H Bond Addition/Amine-Mediated Cyclization of Bis-Michael Acceptors.

    Science.gov (United States)

    Potter, Tyler J; Ellman, Jonathan A

    2016-08-05

    A Rh(III)-catalyzed C-H bond addition/primary amine-promoted cyclization of bis-Michael acceptors is reported. The C-H bond addition step occurs with high chemoselectivity, and the subsequent intramolecular Michael addition, mediated by a primary amine catalyst, sets three contiguous stereocenters with high diastereoselectivity. A broad range of directing groups and both aromatic and alkenyl C-H bonds were shown to be effective in this transformation, affording functionalized piperidines, tetrahydropyrans, and cyclohexanes.

  11. Rh(III)-Catalyzed C–H Bond Addition/Amine-Mediated Cyclization of Bis-Michael Acceptors

    OpenAIRE

    Potter, Tyler J.; Jonathan A. Ellman

    2016-01-01

    A Rh(III)-catalyzed C–H bond addition/primary amine-promoted cyclization of bis-Michael acceptors is reported. The C–H bond addition step occurs with high chemoselectivity, and the subsequent intramolecular Michael addition, mediated by a primary amine catalyst, sets three contiguous stereocenters with high diastereoselectivity. A broad range of directing groups and both aromatic and alkenyl C–H bonds were shown to be effective in this transformation, affording functionalized piperidines, tet...

  12. Compassionate leadership? Some reflections on the work and life of Michael Lapsley

    Directory of Open Access Journals (Sweden)

    Ian A. Nell

    2016-03-01

    Full Text Available In June 2007, I had the privilege of attending a Healing of Memories workshop lead by Father Michael Lapsley, one of the founder members of the Institute for Healing of Memories. The purpose of the workshop was to help the predominantly white members of a middle class Dutch Reformed congregation in the Northern Suburbs of Cape Town and the predominantly coloured members of a congregation of the Evangelical Lutheran Church in Elsies River on the Cape Flats, to share their stories of the past with regard to apartheid with each other. Apart from the stories that were told and the sharing of experiences about the apartheid history that took place, I was struck by the way in which Father Lapsley conducted the workshop. There was a deep compassion for all the participants as was embodied through the way in which he treated each of us with respect. But apart from his cordiality in leading the workshop, one could sense a deeper source of compassion, a source revealing a compassionate understanding of God�s presence amidst the violence and turmoil in our broken world. The aim of this article is to reflect on whether one could speak of something like �compassionate leadership�, and to take a closer look at the relationship between compassion and God images in the life and work of Michael Lapsley. Special attention will be given to the way in which he exercises leadership through his many involvements related to his own personal story of trauma.Intradisciplinary and/or interdisciplinary implications: This article presents literary research on the notion of compassionate leadership as a specific kind of leadership. The results indicate that the leadership of Father Michael Lapsley does indeed portray features of this kind of leadership. The research can become the source for finding new strategies for religious leadership.

  13. POLYETHYLENEIMINE (PEI ON SILICA AS CATALYST IN KNOEVENAGEL AND MICHAEL REACTIONS

    Directory of Open Access Journals (Sweden)

    FATIHA ZAOUI

    2017-03-01

    Full Text Available After the synthesis of polyethylenimine supported on silica, it has been used as a new and efficient catalyst in Knoevenagel and Michael condensations. The presence of the polyethylenimine in the catalytic system together with silica displays an acido-basic character allows a better catalytic activity in the condensations. Carried out under microwave irradiation, without organic solvent and during short time, the syntheses are respectful towards green chemistry. The solid catalyst can be easily reused. This catalyst has the acido-basic character at the same time.

  14. Michael E. Lamb: Award for Distinguished Senior Career Contributions to Psychology in the Public Interest.

    Science.gov (United States)

    2015-11-01

    The APA Awards for Distinguished Contributions to Psychology in the Public Interest recognize persons who have advanced psychology as a science and/or profession by a single extraordinary achievement or a lifetime of outstanding contributions in the public interest. The 2015 co-recipient of the Award for Distinguished Senior Career Contributions to Psychology in the Public Interest is Michael E. Lamb. Lamb was selected because his "work profoundly shaped the fields of developmental psychology, social welfare, child and family policy, and law." Lamb's award citation, biography, and a selected bibliography are presented here. (c) 2015 APA, all rights reserved).

  15. Realismo y antirrealismo en la filosofía de Michael Dummett

    OpenAIRE

    Pablo Cubides; David González; David Rey

    2013-01-01

    Michael Dummett es reconocido por haber propuesto una caracterización semántica del debate realismo-antirrealismo. A partir de esta caracterización, Dummett busca defender una aproximación ascendente a los problemas metafísicos tradicionales, la cual consiste en resolver los desacuerdos metafísicos entre el realista y el antirrealista mediante la elaboración de teorías semánticas para ciertos conjuntos de enunciados. En este artículo argumentamos que la caracterización de Dummett no captura l...

  16. Singleton Michael, Histoires d’eauLouvain-la-Neuve, Academia Bruylant, Anthropologie prospective, 2010

    Directory of Open Access Journals (Sweden)

    Jean Philippe Cornélis

    2012-06-01

    Full Text Available Prendre en main le livre d’un anthropologue comme Michael Singleton donne l’assurance de rentrer dans des récits cosmogoniques croustillants, démontrant la relativité de nos certitudes culturelles, et surtout, la profondeur de nos angoisses existentielles et missionnaires à vouloir convertir les autres à nos propres certitudes, pourtant bien branlantes et même caduques à l’heure des grands bouleversements climatiques, économiques et démographiques, l’occident ayant poussé jusqu’à l’extrême dé...

  17. Le contrat documentaire chez Michael Moore : de l'info-argument vers l'info-tainment

    OpenAIRE

    Lipson, David

    2015-01-01

    Michael Moore is a cultural icon in the United States. The mere mention of his name evokes polemics, political protest but also blockbuster documentary films (The Academy award winning Bowling For Columbine and Fahrenheit 9/11 which won the Palme d’Or at Cannes). The six films of this corpus—Roger & Me (1989), The Big One (1998), Bowling For Columbine (2002), Fahrenheit 9/11 (2004), Sicko (2007) and Captain Mike Across America (Slacker Uprising) (2008)—, are problematic in three ways: the dis...

  18. Neurodinámica clínica Michael Shacklock. Madrid: Elsevier; 2007

    National Research Council Canada - National Science Library

    Gómez Conesa, Antonia

    2007-01-01

    ... que pueden tratarse me- diante las técnicas neurodinámcas y movilizaciones diseñadas desde este modelo, en especial los mecanismos de dolor neurógeno periférico. Coincidiendo con la es- tancia en Europa de Michael Shacklock, la editorial El- sevier publica en español la primera edición de su libro Neurodinámica clínica. A lo largo de 2...

  19. The extraordinary impact of Michael Faraday on chemistry and related subjects.

    Science.gov (United States)

    Thomas, John Meurig

    2017-08-25

    Biographers of Michael Faraday, as well as many dictionaries of science, often describe him as a physicist, which he certainly was. But he was also an astonishingly effective chemist: in fact, he was the Fullerian Professor of Chemistry (at the Royal Institution, RI) from 1834 until the time of his death in August, 1867. To mark the sesquicentenary of his passing, this editorial, by one of his distant successors as Director and Fullerian Professor at the RI, focuses on Faraday's output and influence as a scientist.

  20. Genre in the function of irony: Literary revenge of Michael Psellos

    Directory of Open Access Journals (Sweden)

    Repajić Milena

    2015-01-01

    Full Text Available The paper deals with the problem of genres and methodological digressions in the sixth book of Michael Psellos’ Chronographia, in the context of contemporary genre theories. Conventional opinions about author’s motives for composing digressions about genre and about the complex argument he leaves for interpretation of his own text will be questioned. The main thesis is that the genre-play within history - primarily the use of drama and encomium - has a role in depicting the ironic portrait of the emperor Constantine IX Monomachos. [Projekat Ministarstva nauke Republike Srbije, br. 177015

  1. LECTURE CANCELLED - “The power of collaboration - innovating collaborative relationships" by Michael Kimmel | 8 March

    CERN Document Server

    2013-01-01

    PLEASE NOTE THAT THIS LECTURE IS CANCELLED Friday, 8 March -  from 11.30 a.m. to 1 p.m. Globe of Science and Innovation Route de Meyrin, 1211 Geneva International Women’s Day Conference Lecture will be in English - Interpreting available in French Limited number of seats - registration is essential Reservation: + 41 22 767 76 76 or cern.reception@cern.ch Dr. Michael Kimmel, a renowned sociologist and an expert on male-female relationships, will share his latest findings on gender collaboration and how it can lead to innovation and improved relationships both at work and in the world outside. Michael Kimmel is among the world’s leading experts on male-female relationships. A Professor of Sociology at the State University of New York at Stony Brook, he is the author or editor of more than 20 books on the topic. He consults corporations, NGOs and public sector organisations all over the world on gender equity issues, including work-family balance, reducing workplac...

  2. Design, synthesis and QSAR study of novel isatin analogues inspired Michael acceptor as potential anticancer compounds.

    Science.gov (United States)

    Wang, Jiabing; Yun, Di; Yao, Jiali; Fu, Weitao; Huang, Fangyan; Chen, Liping; Wei, Tao; Yu, Cuijuan; Xu, Haineng; Zhou, Xiaoou; Huang, Yanqing; Wu, Jianzhang; Qiu, Peihong; Li, Wulan

    2017-12-18

    Molecular hybridization is considered as an effective tactic to develop drugs for the treatment of cancer. A series of novel hybrid compounds of isatin and Michael acceptor were designed and synthesized on the basis of association principle. These hybrid compounds were tested for cytotoxic potential against human cancer cell lines namely, BGC-823, SGC-7901 and NCI-H460 by MTT assay. Most compounds showed good anti-growth activities in all tested human cancer cells. SAR and QSAR analysis may provide vital information for the future development of novel anti-cancer inhibitors. Notably, compound 6a showed potent growth inhibition on BGC-823, SGC-7901 and NCI-H460 with the IC50 values of 3.6 ± 0.6, 5.7 ± 1.2, 3.2 ± 0.7 μM, respectively. Besides, colony formation assays, wound healing assays and flow cytometry analysis indicated 6a exhibited a potent anti-growth and anti-migration ability in a concentration-dependence manner through arrested cells in the G2/M phase of cell cycle. Moreover, 6a significantly repressed tumor growth in a NCI-H460 xenograft mouse model. Overall, our findings suggested isatin analogues inspired Michael acceptor may provide promising lead compounds for the development of cancer chemotherapeutics. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  3. Traces of the Unrepresentable in the Modernist Discourse of Clement Greenberg and Michael Fried

    Directory of Open Access Journals (Sweden)

    Gal, Nissim

    2013-08-01

    Full Text Available The present essay aims to remap the modernist writing of Clement Greenberg and his successor Michael Fried from the late 1930s to the 1960s. For many years these two critics/theorists were considered leaders of the American modernist camp that promoted the purity of the medium and the total dependence of reading art on the primacy of perception. Attentive reading of the canonical texts they authored will surprisingly reveal that between the theoretical lines of their writings dwells an essential element that contradicts the absolute dominance of eyesight. Lying at the heart of the Greenbergian act is a metaphysical foundation that poses the question of the invisible as part of the inquiry into the "essence of the visible". As such the modernist debate will be revealed not only as a means for assembling a canon of works, but also as a means to formulating an experience of revelation in terms of the visual. Attentive reading of the writings of Clement Greenberg and the early Michael Fried, reveals a theoretical element or regulative idea that will be termed here "the unrepresentable".

  4. Mechanism of arylating quinone toxicity involving Michael adduct formation and induction of endoplasmic reticulum stress.

    Science.gov (United States)

    Wang, Xinhe; Thomas, Beena; Sachdeva, Rakesh; Arterburn, Linnea; Frye, Lucy; Hatcher, Patrick G; Cornwell, David G; Ma, Jiyan

    2006-03-07

    Quinones permeate our biotic environment, contributing to both homeostasis and cytotoxicity. All quinones generate reactive oxygen species through redox cycling, while partially substituted quinones also undergo arylation (Michael adduct formation) yielding covalent bonds with nucleophiles such as cysteinyl thiols. In contrast to reactive oxygen species, the role of arylation in quinone cytotoxicity is not well understood. We found that the arylating quinones, including unsubstituted 1,4-benzoquinone (1,4-BzQ) and partially substituted vitamin E congener gamma-tocopherol quinone (gamma-TQ), were cytotoxic, with gamma-TQ > 1,4-BzQ, whereas the fully substituted nonarylating vitamin E congener alpha-tocopherol quinone was not. In vitro, both arylating quinones formed Michael adducts with the thiol nucleophile N-acetylcysteine (NAC) at rates where 1,4-BzQ > gamma-TQ. In cultured cells, concurrent addition of NAC eliminated 1,4-BzQ caused toxicity, but preincubation was required for the same NAC detoxification effect on gamma-TQ. These data clearly established the role of arylation in quinone toxicity and revealed that arylating quinone structure affects cytotoxicity by governing detoxification through the rate of adduct formation. Furthermore, arylating quinones induced endoplasmic reticulum (ER) stress by activating the pancreatic ER kinase (PERK) signaling pathway including elF2alpha, ATF4, and C/EBP homologous protein (CHOP). Detoxification by NAC greatly attenuates CHOP induction in arylating quinone-treated cells, suggesting that ER stress is a cellular mechanism for arylating quinone cytotoxicity.

  5. Michael Polanyi and his generation origins of the social construction of science

    CERN Document Server

    Nye, Mary Jo

    2011-01-01

    In Michael Polanyi and His Generation, Mary Jo Nye investigates the role that Michael Polanyi and several of his contemporaries played in the emergence of the social turn in the philosophy of science. This turn involved seeing science as a socially based enterprise that does not rely on empiricism and reason alone but on social communities, behavioral norms, and personal commitments. Nye argues that the roots of the social turn are to be found in the scientific culture and political events of Europe in the 1930s, when scientific intellectuals struggled to defend the universal status of scientific knowledge and to justify public support for science in an era of economic catastrophe, Stalinism and Fascism, and increased demands for applications of science to industry and social welfare. At the center of this struggle was Polanyi, who Nye contends was one of the first advocates of this new conception of science. Nye reconstructs Polanyi’s scientific and political milieus in Budapest, Berlin, and Manchester f...

  6. Michael Addition Polymerization of Trifunctional Amine and Acrylic Monomer: A Versatile Platform for Development of Biomaterials.

    Science.gov (United States)

    Cheng, Weiren; Wu, Decheng; Liu, Ye

    2016-10-10

    Michael addition polymerizations of amines and acrylic monomers are versatile approaches to biomaterials for various applications. A combinatorial library of poly(β-amino ester)s and diverse poly(amido amine)s from diamines and diacrylates or bis(acrylamide)s have been reported, respectively. Furthermore, novel linear and hyperbranched polymers from Michael addition polymerizations of trifunctional amines and acrylic monomers significantly enrich this category of biomaterials. In this Review, we focus on the biomaterials from Michael addition polymerizations of trifunctional amines and acrylic monomers. First we discuss how the polymerization mechanisms, which are determined by the reactivity sequence of the three types of amines of trifunctional amines, i.e., secondary (2°) amines (original), primary (1°) amines, and 2° amines (formed), are affected by the chemistry of monomers, reaction temperature, and solvent. Then we update how to design and synthesize linear and hyperbranched polymers based on the understanding of polymerization mechanisms. Linear polymers containing 2° amines in the backbones can be obtained from polymerizations of diacrylates or bis(acrylamide)s with equimolar trifunctional amine, and several approaches, e.g., 2A2+BB'B″, A3+2BB'B', A2+BB'B″, to hyperbranched polymers are developed. Further through molecular design of monomers, conjugation of functional species to 2° amines in the backbones of linear polymers and the abundant terminal groups of hyperbranched polymers, the amphiphilicity of polymers can be adjusted, and additional stimuli, e.g., thermal, redox, reactive oxidation species (ROS), and light, responses can be integrated with the intrinsic pH response. Finally we discuss the applications of the polymers for gene/drug delivery and bioimaging through exploring their self-assemblies in various motifs, e.g., micelles, polyplexes particles/nanorings and hydrogels. Redox-responsive hyperbranched polymers can display 300 times

  7. An Ionic Liquid Containing L-Proline Moiety as Highly Efficient and Recyclable Chiral Organocatalyst for Michael Addition

    Energy Technology Data Exchange (ETDEWEB)

    Li, Jiang; Li, Xia Bing; Ma, Sha Sha; Liu, Juan; Li, Ben Hao; Li, Bao Lin [Shaanxi Normal University, Xi' an (China)

    2016-08-15

    A novel chiral ionic liquid containing proline moiety was synthesized. It can be used as a highly efficient and recyclable chiral organocatalyst for Michael addition of cyclohexanone with (E)-β-nitroalkenes in methanol at room temperature. The Michael addition affords the corresponding products in satisfactory yields of isolated products ( 78-98%) with high diastereoselectivities and excellent enantioselectivities (up to 98% dr and up to 99% ee). The catalyst can be recycled up to five times without any decrease in yields and stereoselectivities.

  8. Las relaciones entre la Iglesia y el Estado en la teoría de la justicia de Michael Walzer

    OpenAIRE

    Roldán, Alberto Fernando

    2009-01-01

    Roldan, A. F. (2009). Las relaciones entre la Iglesia y el Estado en la teoría de la justicia de Michael Walzer (Tesis de Maestría). Universidad Nacional de Quilmes, Bernal, Argentina. En la presente tesis, se discuten las relaciones entre la Iglesia –término que se utiliza no en el sentido confesional sino en tanto institución religiosa- y el Estado moderno. Se escoge como marco teórico la filosofía política del pensador judío americano Michael Walzer, exponente del “comunitarismo”, un...

  9. N-Heterocyclic Carbene-Catalysed Diastereoselective Vinylogous Michael Addition Reaction of gamma-Substituted deconjugated Butenolides

    KAUST Repository

    Guo, Hao

    2015-11-16

    An efficient N-heterocyclic carbene (NHC)-catalysed vinylogous Michael addition of deconjugated butenolides was developed. In the presence of 5 mol% of the NHC catalyst, both γ-alkyl and aryl-substituted deconjugated butenolides undergo vinylogous Michael addition with various α, β-unsaturated ketones, esters, or nitriles to afford γ,γ-disubstituted butenolides containing adjacent quaternary and tertiary carbon centers in good to excellent yields with excellent diastereoselectivities. In this process, the free carbene is assumed to act as a strong Brønsted base to promote the conjugate addition.

  10. Enantio- and Stereoselective Construction of Atisane Scaffold via Organocatalytic Intramolecular Michael Reaction and Diels-Alder Reaction.

    Science.gov (United States)

    Sekita, Hiroko; Adachi, Kyohei; Kobayashi, Ippei; Sato, Yusuke; Nakada, Masahisa

    2017-05-05

    An enantio- and stereoselective construction of the atisane scaffold via organocatalytic intramolecular Michael reaction and Diels-Alder reaction is described. The organocatalytic intramolecular Michael reaction has been found to stereoselectively generate a trans-stereodiad comprising an all-carbon quaternary and a tertiary stereogenic centers. Use of the chiral secondary amine bearing thiourea with benzoic acid as additive is the key to obtaining the desired product with excellent ee in synthetically acceptable yield. The prepared chiral building block has been successfully converted to the compound including the atisane scaffold via the highly stereoselective intramolecular Diels-Alder reaction.

  11. Site-Specific Tandem Knoevenagel Condensation-Michael Addition To Generate Antibody-Drug Conjugates.

    Science.gov (United States)

    Kudirka, Romas A; Barfield, Robyn M; McFarland, Jesse M; Drake, Penelope M; Carlson, Adam; Bañas, Stefanie; Zmolek, Wes; Garofalo, Albert W; Rabuka, David

    2016-11-10

    Expanded ligation techniques are sorely needed to generate unique linkages for the growing field of functionally enhanced proteins. To address this need, we present a unique chemical ligation that involves the double addition of a pyrazolone moiety with an aldehyde-labeled protein. This ligation occurs via a tandem Knoevenagel condensation-Michael addition. A pyrazolone reacts with an aldehyde to generate an enone, which undergoes subsequent attack by a second pyrazolone to generate a bis-pyrazolone species. This rapid and facile ligation technique is performed under mild conditions in the absence of catalyst to generate new architectures that were previously inaccessible via conventional ligation reactions. Using this unique ligation, we generated three site-specifically labeled antibody-drug conjugates (ADCs) with an average of four drugs to one antibody. The in vitro and in vivo efficacies along with pharmacokinetic data of the site-specific ADCs are reported.

  12. 'Introducing Michael Gove to Loïc Wacquant': Why Social Work Needs Critical Sociology.

    Science.gov (United States)

    Michael Garrett, Paul

    2016-06-01

    In 2013, Michael Gove, then Secretary of State for Education and Health in the UK coalition government, criticised social workers for laying insufficient emphasis on the 'agency' of individuals and for being too preoccupied with social and economic inequalities. Such a perspective, which is not unique to Gove, needs to be countered by reaffirming the significance of an expansively critical sociology for social work. In this context, the thematic concerns of the French theorist, Loïc Wacquant, illuminates key aspects of social work engagement with clients which Gove and his ideological associates appear intent on ignoring. The issues raised have significant political resonances given the pending UK General Election taking place in May 2015.

  13. Candid reflections of a businessman in Washington: interview with Secretary of the Treasury, W. Michael Blumenthal.

    Science.gov (United States)

    Blumenthal, W M

    1979-01-29

    In the interview published by Fortune, W. Michael Blumenthal, Secretary of the Treasury and former Chief Executive Officer and Chairman of Bendix Corporation, discusses his transition from being a business executive to becoming a senior member of the cabinet. Blumenthal compares the workings of the corporate world with the ways of Washington. Essentially, he views the business world as less complex, allowing a manager flexibility as long as he performs successfully. In government, administrative practices are more regulated with most policy decisions determined in the public arena making the managerial process much slower and more complex. Despite the differences between the corporate world and Washington, Blumenthal identifies four basic management principles that are valid for both; (1) choose very good people; (2) learn to delegate authority; (3) know your facts; and (4) be honest. Blumenthal has found his tenure in government to be interesting and rewarding and encourages other businessmen to seek the challenge of government service.

  14. Linguistic Theories and Intellectual History in Michael Baxandall’s Giotto and the Orators

    Directory of Open Access Journals (Sweden)

    Allan Langdale

    2009-12-01

    Full Text Available This essay examines some theoretical and methodological aspects of Michael Baxandall’s book Giotto and the Orators. Humanist observers of painting in Italy and the discovery of pictorial composition of 1971. It includes reflections on the book’s reorientations of the scholarly debate over the relationship between Renaissance/Early Modern humanism and painting, as well as consideration of the linguistic theories that either directly or tangentially inform Baxandall’s method. Sources such as Wittgenstein, Cassirer, Ordinary Language Philosophy, and the Sapir-Whorf Hypothesis are discussed. Some of the book’s aims and methods are clarified by a comparison to Panofsky’s Gothic Architecture and Scholasticism of 1951.

  15. A History of Experiences and Thinking Men. The History of Political Thought according to Michael Oakeshott

    Directory of Open Access Journals (Sweden)

    Spartaco Pupo

    2014-12-01

    Full Text Available Michael Oakeshott conceives the history of European political thought as a structuring of ideas and arguments of the practical experience aimed to understanding political expressions in vogue in the culture of a people. It is not a continuous and cumulative history of abstract and disembodied ideas, as it is wrongly conceived, but of some men who thought politics in a certain way on the basis of the language and of the set of actions, moral beliefs and contingencies of the people which they belong to. The article highlights the comparison between Oakeshott, Quentin Skinner and Gianfranco Miglio on the search for the most appropriate method to be applied in the study of the history of political thought.

  16. Michael Oakeshott´s Work as a Liberal-Conserv ative Paradigm

    Directory of Open Access Journals (Sweden)

    Josep Baqués

    2014-01-01

    Full Text Available As is the case with other thinkers linked to what can be broadly defined as conservatism, it is arguable whether Michael Oakeshott was just a conservative, or whether he was also a liberal. He often rejected this last label. He also tried to avoid the classic debate between the left/right wing divide, conferring instead a mantle of neutrality on his work. This analysis shows, on the one hand, that Oakeshott´s work is ideologically orientated and, on the other hand, that it contains a substantial liberal component. In fact, he offered a liberal-conservative synthesis in which the free market appears to be not only the best, but the only feasible outcome in the proposed scenario of political prudence. I will fi rst connect Oakeshott with the main traditions of thought, then analyse the theoretical implications of his position, and finally explore the consequences derived from all this for everyday political practice.

  17. A highly selective fluorescent probe based on Michael addition for fast detection of hydrogen sulfide.

    Science.gov (United States)

    Gao, Baozhen; Cui, Lixia; Pan, Yong; Xue, Minjie; Zhu, Boyu; Zhang, Guomei; Zhang, Caihong; Shuang, Shaomin; Dong, Chuan

    2017-02-15

    A new 4-hydroxy-1,8-naphthalimide-based compound (probe 1) has been designed and synthesized. The colorimetric and fluorescent properties of probe 1 towards hydrogen sulfide (H2S) were investigated in detail. The results show that the probe 1 could selectively and sensitively recognize H2S rather than other reactive sulfur species. The reaction mechanism of this probe is an intramolecular cyclization caused by the Michael addition of H2S to give 4-hydroxy-1,8-naphthalimide. The intramolecular charge transfer of 4-hydroxy-1,8-naphthalimide is significant. Probe 1 quickly responded to H2S and showed a 75-fold fluorescence enhancement in 5min. Moreover, probe 1 could detect H2S quantitatively with a detection limit as low as 0.23μM. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Cyclopropanation of Various Substrates via Simmons-Smith and Michael-Initiated Ring Closure (MIRC Reactions

    Directory of Open Access Journals (Sweden)

    Yudhi Dwi Kurniawan

    2016-01-01

    Full Text Available Cyclopropanation of various electron rich and electron deficient olefins via Simmons-Smith and Michael-initiated ring closure reactions was studied in our research. Cinnamyl alcohol 18 was succesfully cyclopropanated in a good to excellent yield using Simmons-Smith reactions. Methyl and benzyl crotonate 14 and 16 were labile in MIRC reaction condition indicated by the detection of starting material degradation in the NMR spectra of the crude reactions, and allowed a low to moderate product yield. The other starting materials, i.e., cinnamaldehyde 19, methyl cinnamate 20, mono- and di-protected cross-coupled product (4R,5R,E-methyl 5-(tert-butyldimethylsilyloxy-4-hydroxyhepta-2,6-dienoate 25 and (4R,5R,E-methyl 5-(tert-butyldimethylsilyloxy-4-(methoxymethoxyhepta-2,6-dienoate 26, were apparently incompatible to the reaction condition set in our study.

  19. Lizards, ticks and contributions to Australian parasitology: C. Michael Bull (1947-2016).

    Science.gov (United States)

    Godfrey, Stephanie S; Gardner, Michael G

    2017-12-01

    Professor C. Michael Bull was a great scientist and mentor, and an Associate Editor of this journal. While his research career spanned the fields of behavioural ecology, conservation biology and herpetology, in this article, we pay tribute to his major contribution to Australian parasitology. Mike authored more than eighty articles on host-parasite ecology, and revealed major insights into the biology and ecology of ticks from his long term study of the parapatric boundary of two tick species ( Amblyomma limbatum and Bothriocroton hydrosauri ) on the sleepy lizard ( Tiliqua rugosa ). In this article, we provide an overview of how this research journey developed to become one of the longest-running studies of lizards and their ticks, totalling 35 years of continuous surveys of ticks on lizards, and the insights and knowledge that he generated along that journey.

  20. Inverting the diastereoselectivity of the mukaiyama-michael addition with graphite-based catalysts

    KAUST Repository

    Acocella, Maria Rosaria

    2014-02-07

    Here, we show that graphite-based catalysts, mainly graphite oxide (GO) and exfoliated GO, are effective recyclable catalysts for a relevant stereoselective Mukaiyama-Michael addition, outperforming currently available catalysts. Moreover, the graphite-based catalysts described here invert the diastereoselectivity relative to that observed with known catalysts, with the unprecedented large prevalence of the anti diastereoisomer. This inverted diastereoselectivity is increased when the catalyst concentration is reduced and after catalyst recycling. Density functional theory calculations suggest that the selectivity is determined by two types of supramolecular interactions operating between the catalyst and the substrates at the diastereoselectivity- determining transition state, specifically, the π-stacking of b-nitrostyrene with graphite and the van der Waals interaction between the SiMe3 group of the silyl ether and the graphite. © 2013 American Chemical Society.

  1. Modernism, Tehatricality, and Scepticism: Michael Fried and Cavell’s Conception of the Ordinary Language Philosophy

    Directory of Open Access Journals (Sweden)

    Nikola Dedić

    2016-04-01

    Full Text Available The paper treats the relationship between the art historian Michael Fried and the philosopher Stanley Cavell, as well as their readings of Wittgenstein’s late philosophy. It argues that Fried’s entire historic-artistic method rests on Wittgensteinian grounds; there is special emphasis on theses concerning the grammatical criteria of language and scepticism. Namely, Fried, like Cavell, interprets modernism as a crisis of a priori criteria by which we come to think a given object as a successful work of art. Fried labels an artwork’s failure to convince, to communicate with the recipient, with the term theatre. This text establishes an analogy between Fried’s concept of theatre, Cavell’s concept of scepticism, and Wittgenstein’s thesis of the impossibility of a private language, situating those theses in the wider context of discussions of modernism.

  2. Rationalism and traditionalism in politics. The correspondence between Karl R. Popper and Michael Oakeshott

    Directory of Open Access Journals (Sweden)

    Spartaco Pupo

    2016-07-01

    Full Text Available The correspondence of 1948 between Karl Popper and Michael Oakeshott, translated for the first time in Italian and published in the appendix to this paper, demonstrates the existence of two different ways of thinking about politics: the rationalist approach, founded on the “argumentation” as a rational means for the non-violent solution of problems (Popper, and the traditionalist mode, inspired by the method of “conversation” as a guarantee of constant openness to the diversity of identities (Oakeshott. To rise from the letters is a mutual influence on the interpretation of the key concepts that characterize the thought of the two authors, which however does not cancel the fundamental divergence of their political orientation.

  3. "Alarme de incêndio": Michael Löwy e a crítica ecossocialista da civilização capitalista moderna "Fire alarm": Michael Löwy and the ecosocialist critique of the modern capitalist civilization

    Directory of Open Access Journals (Sweden)

    Fabio Mascaro Querido

    2013-04-01

    Full Text Available A emergência da crise ecológica, como sintoma mais nítido de uma verdadeira crise civilizató-ria, impôs novos desafios ao pensamento crítico e, em especial, ao marxismo. Partindo desse pressuposto, o objetivo deste artigo é apresentar a defesa de Michael Löwy de uma radicalização ecossocialista da crítica marxista da modernidade, tarefa para a qual a grande recusa de Walter Benjamin das ideologias do pro- gresso é uma das fontes decisivas de inspiração. Para Michael Löwy, a ruptura com as ideologias do progresso e com o paradigma civilizatório capitalista moderno é uma condição indispensável para a atua-lização ecossocialista do marxismo.The emergence of the ecological crisis as a clearer symptom of a true civilizatory crisis has imposed new challenges to critical thought and, in particular, to Marxism. Based on this assumption, this article aims to present Michael Löwy's defense of an ecosocialist radicalization of the Marxist critique of modernity, a task for which Walter Benjamin's great refusal of the ideologies of progress is one of the critical sources of inspiration. To Michael Löwy, breaking away from the ideologies of progress and from the modern capitalistic civilizatory paradigm is a prerequisite for the ecosocialist updating of Marxism.

  4. Michael Novak's "Business as a Calling" as a Vehicle for Addressing Ethical and Policy Concerns in a Business Law Course

    Science.gov (United States)

    Murphy, Tonia Hap

    2008-01-01

    This article describes the author's experience of incorporating Michael Novak's "Business as a Calling: Work and the Examined Life" into a Business Law course. The author views it as a positive addition to the course, one that may be of interest to her colleagues at other institutions. Accordingly, after an overview of Novak's analysis in…

  5. Michael Francis Madelin (1931--2007): a pioneer in the biology and ecology of conidial fungi and slime moulds.

    Science.gov (United States)

    Campbell, Richard

    2008-12-01

    Michael F Madelin (1931--2007) was Programme Secretary, Vice-President, and President of the British Mycological Society. A summary of his research on Coprinopsis, various conidial fungi, Coelomomyces and myxomycetes is presented, with a full list of his publications. His teaching career was initially at Imperial College, University of London, and then mostly at the University of Bristol.

  6. Enantioselective synthesis of benzofurans and benzoxazines via an olefin cross-metathesis-intramolecular oxo-Michael reaction.

    Science.gov (United States)

    Zhang, Jun-Wei; Cai, Quan; Gu, Qing; Shi, Xiao-Xin; You, Shu-Li

    2013-09-11

    Chiral phosphoric acid and Hoveyda-Grubbs II were found to catalyze an olefin cross-metathesis-intramolecular oxo-Michael cascade reaction of the ortho-allylphenols and enones to provide a variety of benzofuran and benzoxazine derivatives in moderate to good yields and enantioselectivity.

  7. Effective Integration of Technology and Instruction. Q&A with Michael Jay. REL Mid-Atlantic Educator Effectiveness Webinar Series

    Science.gov (United States)

    Regional Educational Laboratory Mid-Atlantic, 2015

    2015-01-01

    In this webinar, long-time educator and developer of education technology Michael Jay discussed the importance of using technology to support learning and gave examples of how teachers can integrate technology into their instruction based on the Common Core State Standards and the Next Generation Science Standards. The PowerPoint presentation and…

  8. Komparativistlikke ja kultuuriteaduslikke ärgitusi Baltimaade germanistikale / Michael Schwidtal ; saksa keelest tõlkinud Vahur Aabrams

    Index Scriptorium Estoniae

    Schwidtal, Michael

    2001-01-01

    3. - 5. sept. 2001 toimus Riias sümpoosion "Unter diesem braunen Himmel. Jakob Michael Reinhold Lenz und die deutsche Literatur des Baltikums", 7. - 9. sept. Tartus "Torm ja tung Liivimaal. Mässu mudelid", pühendatud J. M. R. Lenzi ja Kristian Jaak Petersoni loomingule. Ülevaade

  9. Rezension: Österreichische Archivgeschichte. Vom Spätmittelalter bis zum Ende des Papierzeitalters von Michael Hochedlinger

    OpenAIRE

    Valerie Strunz

    2014-01-01

    Valerie Strunz hat für die LeserInnen der MEDIENIMPULSE die 'Österreichische Archivgeschichte' von Michael Hochedlinger rezensiert. Der Band ist eine Fundgrube für alle, die sich für Geschichte und das Archiv interessieren ...

  10. Rezension: Österreichische Archivgeschichte. Vom Spätmittelalter bis zum Ende des Papierzeitalters von Michael Hochedlinger

    Directory of Open Access Journals (Sweden)

    Valerie Strunz

    2014-12-01

    Full Text Available Valerie Strunz hat für die LeserInnen der MEDIENIMPULSE die 'Österreichische Archivgeschichte' von Michael Hochedlinger rezensiert. Der Band ist eine Fundgrube für alle, die sich für Geschichte und das Archiv interessieren ...

  11. What I Think I May Have Learned--Reflections on 50 Years of Teaching: An Interview with Michael Wertheimer

    Science.gov (United States)

    Michael, Kurt D.

    2006-01-01

    Kurt Michael is an associate professor in the Department of Psychology at Appalachian State University (ASU) where he teaches history and systems of psychology, abnormal psychology, child psychopathology, and interventions for children and adolescents. He received his BA (cum laude) from the University of Colorado at Boulder and his MS and PhD in…

  12. HIGHLY DISATEREOSELECTIVE MICHAEL ADDITION OF FLAVANONE TO ITS CHALCONE PRECURSOR UNDER SOLVENT-FREE CONDITIONS USING MICROWAVES [POSTER

    Science.gov (United States)

    Substituted 2'-hydroxychalcones were found to give an equilibrium mixture of the starting chalcone and the corresponding flavanone inf 4.6-1:3 ratio in the presence of DBU gave two hitherto unknown diasteromeric dimers in a highly diastereoselective Michael addition of the carban...

  13. Michael McFaul: venelastele pole kunagi lubatud, et NATO Ida-Euroopasse ei laiene / intervjueerinud Taavi Minnik

    Index Scriptorium Estoniae

    McFaul, Michael

    2016-01-01

    Intervjuu Ameerika Ühendriikide ühe hinnatuma Venemaa-tundja, Stanfordi ülikooli professori ja endise suursaadikuga Venemaal Michael McFauliga viimasel ajal tekkinud USA-Venemaa vastasseisust Läänemerel ning Venemaa ja lääne suhetest

  14. Thomas DaCosta Kaufmann and Michael North (eds., Mediating Netherlandish Art and Material Culture in Asia

    Directory of Open Access Journals (Sweden)

    Claartje Rasterhoff

    2015-12-01

    Full Text Available Book notice of: Thomas DaCosta Kaufmann and Michael North (eds., Mediating Netherlandish Art and Material Culture in Asia (Amsterdam Studies in the Dutch Golden Age Amsterdam, Amsterdam University Press, 2014. 348 pp. ISBN 978-90-8964-569-2. € 99,00.

  15. 78 FR 2391 - CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. Pacific Gas and...

    Science.gov (United States)

    2013-01-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v... and Procedure of the Federal Energy Regulatory Commission (FERC); CAlifornians for Renewable Energy...

  16. N-Heterocyclic-Carbene-Catalysed Diastereoselective Vinylogous Mukaiyama/Michael Reaction of 2-(Trimethylsilyloxy)furan and Enones

    KAUST Repository

    Wang, Ying

    2015-10-15

    N-heterocyclic carbenes have been utilised as highly efficient nucleophilic organocatalysts to mediate vinylogous Mukaiyama/Michael reactions of 2-(trimethylsilyloxy)furan with enones to afford γ-substituted butenolides in 44-99% yield with 3:1-32:1 diastereoselectivity. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. A Symposium on the Relevance of Michael Polanyi's Insights to a Reformulated Understanding of Science, Technology, and Society

    Science.gov (United States)

    Mead, Walter B.

    2011-01-01

    This is intended as an introductory statement to the explorations undertaken in the essays that follow. The authors of these essays attempt to introduce the reader to some of the insights of Michael Polanyi and their implications for the reader who wishes to come to a greater understanding of modern technological society, which--for better or…

  18. The works of Joseph and Michael Haydn in Ondřej Horník's collection

    Czech Academy of Sciences Publication Activity Database

    Freemanová, Michaela

    2017-01-01

    Roč. 9, 1-2 (2017), s. 14-23 ISSN 1803-7828 Institutional support: RVO:68378076 Keywords : music manuscripts * Joseph Haydn * Michael Haydn * Ondřej Horník's collection * church music Subject RIV: AL - Art, Architecture, Cultural Heritage

  19. Book Review: America’s Blind Spot: Chávez, Oil and US Security by Andrés Cala and Michael Economides

    DEFF Research Database (Denmark)

    Boscan, Luis

    2013-01-01

    Review of: America’s Blind Spot: Chávez, Oil and US Security. Andrés Cala and Michael Economides. Continuum Books. 2012.......Review of: America’s Blind Spot: Chávez, Oil and US Security. Andrés Cala and Michael Economides. Continuum Books. 2012....

  20. Der Wert von Worten. Michael Serrer aus dem Literaturbüro Düsseldorf im Interview mit der Textpraxis-Redaktion

    Directory of Open Access Journals (Sweden)

    Michael Serrer

    2014-11-01

    Full Text Available Die Textpraxis-Redaktion unterhält sich mit Michael Serrer über Literaturvermittlung in Zeiten der Digitalisierung, über Kanonisierung und die Rolle der Literatur in der Gesellschaft. Michael Serrer ist Leiter des Literaturbüros NRW und Feuilletonist.

  1. An Oral History Interview with MICHAEL M. CERNEA (interviewer: Judith Freidenberg

    Directory of Open Access Journals (Sweden)

    MICHAEL M. CERNEA

    2008-01-01

    Full Text Available The editors and editorial board of Human Organization are pleased to introduce readers to the following oral history interview with Michael M. Cernea, a development social scientist who has militated throughout his academic career and applied work for "putting people first", in the forefront of development projects and policies. Working for a long time for the promotion of anthropological and sociological knowledge, either in the activities of the World Bank or in the policies and programs of governments of both developed and developing countries, Dr. Cernea cleared pathways for applied social science that are sure to benefit people in development settings for many years to come. Undoubtedly many readers already know Dr. Cernea's work well, especially those of us who teach the anthropology of development or work in applied settings and organizations, but this interview embeds his broad body of work into a personal, human, and at times tragic context that opens with brushes with death, Nazi brutality, and exile. It also provides valuable insights for carrying out the work of development anthropologists within large-scale organizations and governments.This interview with Dr. Cernea was conducted by Dr. Judith Freidenberg, of the University of Maryland, on June 30, 2003, for the Society for Applied Anthropology Oral History Project, headquartered at the University of Kentucky Libraries. This Project aims to create, through the vehicle of oral histories, a record of the life, activities and experiences of number of selected scholars-anthropologists who devoted a great part of their scientific work to research, to applied work in different settings, to inducing development, including to hands-on work on crafting public social policies and actual development programs. The present transcript of the interview was reviewed by both participants for editorial purposes. Michael M. Cernea expanded some of his oral responses, for historical accuracy or to add

  2. Anthropology as storytelling: fetishism and terror in Michael Taussig’s early works

    Directory of Open Access Journals (Sweden)

    Lorenzo D’ANGELO

    2016-11-01

    Full Text Available Among anthropologists inspired by Walter Benjamin and the early Frankfurt School, Michael Taussig is notable. For Taussig, Benjamin is like a muse, a source of inspiration to ponder over his extended fieldwork in South America. This article outlines a possible reading path through Taussig’searly works, a path specifically influenced by Benjamin’s insights into topics such as fetishism, violence, and storytelling. In particular, it examines the way Taussig approaches two issues: the Marxian question of commodity fetishism, and the question of writing against terror. The analysis of commodity and State fetishism leads Taussig to reject the symptomatic reading offered by thinkers such as Marx and Freud. The issue of violence or terror drives him to reflect on the politics of representation. In line with Benjamin’s reflections on the role of the storyteller in bourgeois society, Taussig intertwines these two lines of thought and interprets anthropology as a form of storytelling. This article highlights some of the epistemological and ontological assumptions behind this provocative idea. It argues that despite the radical nature of its premises, Taussig defends a weak conception of criticism.

  3. Diffusible gradients are out - an interview with Lewis Wolpert. Interviewed by Richardson, Michael K.

    Science.gov (United States)

    Wolpert, Lewis

    2009-01-01

    In 1969, Lewis Wolpert published a paper outlining his new concepts of "pattern formation" and "positional information". He had already published research on the mechanics of cell membranes in amoebae, and a series of classic studies of sea urchin gastrulation with Trygve Gustavson. Wolpert had presented his 1969 paper a year earlier at a Woods Hole conference, where it received a very hostile reception: "I wasnt asked back to America for many years!". But with Francis Crick lining up in support of diffusible morphogen gradients, positional information eventually became established as a guiding principle for research into biological pattern formation. It is now clear that pattern formation is much more complex than could possibly have been imagined in 1969. But Wolpert still believes in positional information, and regards intercalation during regeneration as its best supporting evidence. However, he and others doubt that diffusible morphogen gradients are a plausible mechanism: "Diffusible gradients are too messy", he says. Since his retirement, Lewis Wolpert has remained active as a theoretical biologist and continues to publish in leading journals. He has also campaigned for a greater public understanding of the stigma of depression. He was interviewed at home in London on July 26th, 2007 by Michael Richardson.

  4. Losing Touch: A Theology of Death for Michael Haneke’s Amour

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    Taylor Worley

    2016-11-01

    Full Text Available This proposed theology of death for Michael Haneke’s Amour, a fraught but poignant piece of cinema, will employ Martin Heidegger’s existentialism to reframe the ethical structure of the film and apply a “lived theology” rejoinder to its perceived hopelessness. The proposal will address the question of ethics in relation to Haneke’s cinema, in particular his seemingly nihilistic perspective and confrontational style. To do so, it will revisit the film itself and examine the ways that Georges and Anne’s love is tested. Principally, we examine the film’s great question, which—in the filmmaker’s own words—is: “How do I cope with the suffering of a loved one?” With aid from the theologian Dietrich Bonhoeffer, this ‘lived theology’ proposal will attempt to give an account of love’s irrepressible strength in the midst of even astounding suffering. While Heidegger’s ethic of resoluteness calls for interiority and solitude, Bonhoeffer’s account of death more satisfactorily invokes a transcendent summons contained within our own pledges to loved ones. Such a theological reading of Haneke’s Amour will draw two distinct conclusions: first, the film exposes the superficiality of any hoped-for solitude or escape from a loved one’s death, and secondly, it demonstrates that the mutuality of authentic love entails impossible sacrifices.

  5. Michael Ondaatje's reinvention of social and cultural Myths: In the Skin of a Lion

    Directory of Open Access Journals (Sweden)

    Branko Gorjup

    1989-12-01

    Full Text Available From the beginning of his writing career in the early sixties until the recent publication of In the Skin of a Lian (1987, the Canada of Michael Ondaatje had represented one thing: a geographical locale which he has selected as his home but which, fundamentally, had failed to engage his imagination. The fictional worlds he created in The Collected Works of Billy the Kid, Coming Through Slaughter and Running in the Family, has been located outside of Canada, each corresponding to an actual place complete with historical and geographical references. For this very reason it has been impossible - as Sam Solecki noted in his introduction to Spider Blues, »a collection of reviews and essays on Ondaatje - to place this anomalous literary presence in Canada within »specifically Canadian tradition of writing ...«,  a tradition that would»include and see relationships among figures as different as Roberts, Pratt, F. R. Scott, Purdy and Atwood ...« Ondaatje's »characters, landscapes, stories and themes resist any taxonomies based on overtly Canadian thematics.« In fact, Solecki further suggested that Ondaatje, like »V. S. Naipaul, Derek Walcott and Salmon Rushdie ..., compels a rethinking of the notion of a national tradition«. Similarly, another critic from the same collection described Ondaatje's position in the context of Canadian writing as unique - a position according to which »language or audience or the identity and the role of the poet are indeterminate. «

  6. Nacionalismos e internacionalismo: um debate entre Michael Löwy e Michel Cahen

    Directory of Open Access Journals (Sweden)

    Ângela Lazagna

    2008-11-01

    Full Text Available Este artigo consiste em um debate realizado entre Michel Löwy e Michael Cahen em meados dos anos 1990 e revisto para esta publicação. Mesmo que a discussão refira-se a acontecimentos que até certo ponto podem ser considerados datados, a preocupação de fundo que é comum a esses artigos concede-lhes atualidade: a necessidade do aprofundamento de uma reflexão, a partir da teoria marxista, sobre o problema dos nacionalismos e do internacionalismo em tempos de mundialização. Esse aprofundamento, segundo os autores, faz-se necessário sobretudo por meio de uma reflexão que rompa criticamente com uma visão eurocêntrica dos diferentes nacionalismos e que supere a atitude de muitos marxistas de desprezarem tudo aquilo que não seja diretamente relevante à "consciência de classe".

  7. Examination of Michael Dummett’s Anti-Realism and Verificationist Approach

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    a Hossein Khani

    2010-05-01

    Full Text Available Anti-realism was first introduced by Michael Dummett, the contemporary analytic philosopher. He has always preferred to discuss about statements and assertions (instead of entities, such as statements in the past tense, statements about the physical world, and so on. Based on his approach to metaphysical problems, we should initially choose an appropriate model of meaning and a proper conception of the notion of truth applicable to the statements. By doing so, the dispute between realism and anti-realism can be rendered to a disagreement on the kind of meaning the statements may have. After criticizing the realist approach, he goes on to claim that without having proper evidence, we cannot judge on meaning and truth or falsity of linguistic statements. To understand a sentence, Dummett says, is to have the capacity of recognizing what would be counted as evidence for or against it. Therefore, an anti-realist believes that there is no guarantee for every sentence to be certainly true (or false. Or, it cannot be approved for each statement to be necessarily true or false, independently of our knowledge and relevant abilities. An adherent of realism, by contrast, admits the principle of bivalence and acknowledges that sentences are true or false because of the reality existing independently of us. In this essay, after introducing Dummett’s anti-realist approach and his criticisms on realism, I am going to discuss about and explain the correlation between his desired theory of meaning and anti-realism.

  8. Novel Interecting Blends Based on Amino Terminited Oligoimides by Using Michael Addition Reaction-II

    Directory of Open Access Journals (Sweden)

    Rita R. Patel

    2012-01-01

    Full Text Available New amino terminated oligoimides (AOIs were prepared by the Michael addition reaction of various bismaleimide (1, namely, 1-(4-((4-((2, 5-dioxocyclopent-3 enylamino methyl cyclohexyl methyl cyclohexyl-1, 6-dihydropyridine-2, 5-dione with excess of various diamines (2a-c. These AOIs were characterized by elemental analysis, FT-IR spectral studies and number average molecular weight estimated by non-aqueous conductometric titrations. AOIs were then treated with acrylol chloride and resultant acryl terminated oligoimides (AcOIs samples were also characterized thermogravimetrically. Each of these AcOI was then combined with the N-phenyl maleimide (PM in THF solvent. The resultant suspensions were then heated in the presence of azobisisobutyronitrile (AIBN as an initiator. The AcOI and PM polymerized through double bond simultaneously and form interacting blends, which were analyzed thermogravimetrically. The glass fiber reinforced composites were fabricated by using the suspensions of the AcOI and PM. The composites of Interacting blends were analyzed for their mechanical, chemical and electrical properties.

  9. A man and his island: The island mirror in Michael Crummey’s Sweetland

    Directory of Open Access Journals (Sweden)

    Laurie Brinklow

    2016-05-01

    Full Text Available Between 1946 and 1975, dozens of islands and outports in the Canadian province of Newfoundland and Labrador were abandoned as part of a government resettlement policy. Families and communities were torn apart, and a culture and way of life that revolved around the fishery changed irrevocably. The practice, which continues to this day, has been well documented, particularly by artists and writers. Michael Crummey’s 2014 novel Sweetland is a recent iteration. The relationship between humans and place is complex: on an island, with compressed space and a very real boundary that is the ocean, emotional attachments to one’s place are often heightened and distilled. What happens when a person is displaced from his or her island; when bonds of attachment are severed and one’s mirrored double is destroyed? Sweetland offers a fictional lens through which we see an example of a mirrored relationship between an island protagonist and his island setting. Exploring themes of attachment to place, and what Barry Lopez calls a “storied” or “reciprocal” relationship with the land, this paper examines what happens to a man when confronted with leaving an island he knows as deeply as his own body and soul; and how the island reacts.

  10. Synthesis of the Hemoglobin-Conjugated Polymer Micelles by Thiol Michael Addition Reactions.

    Science.gov (United States)

    Qi, Yanxin; Li, Taihang; Wang, Yupeng; Wei, Xing; Li, Bin; Chen, Xuesi; Xie, Zhigang; Jing, Xiabin; Huang, Yubin

    2016-06-01

    Amphiphilic triblock copolymers mPEG-b-PMAC-b-PCL are synthesized using methoxyl poly(ethylene glycol), cyclic carbonic ester monomer including acryloyl group, and ε-caprolactone. Copolymers are self-assembled into core-shell micelles in aqueous solution. Thiolated hemoglobin (Hb) is conjugated with micelles sufficiently through thiol Michael addition reaction to form hemoglobin nanoparticles (HbNs) with 200 nm in diameter. The conjugation of Hb onto the micelle surface is further confirmed by X-ray photoelectron spectroscopy. Feeding ratio of copolymer micelles to Hb at 1:3 would lead to the highest hemoglobin loading efficiency 36.7 wt%. The UV results demonstrate that the gas transporting capacity of HbNs is well remained after Hb is conjugated with polymeric micelles. Furthermore, the obtained HbNs have no obvious detrimental effects on blood components in vitro. This system may thus have great potential as one of the candidates to be developed as oxygen carriers and provide a reference for the modification of protein drugs. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. La figura del libro in Die unendliche Geschichte di Michael Ende: da finestra a varco

    Directory of Open Access Journals (Sweden)

    Elena Di Cesare

    2015-01-01

    Full Text Available The book is an object which can be considered as a window in the novel Die unendliche Geschichte (1979 written by Michael Ende. It allows Bastian to look at the world of Phantasien and to communicate indirectly with the Childlike Empress. Furthermore, this object will show its function as an symbol of evolution, which will enable the passage of the protagonist into the world of Phantasien: first the book appears as a window, then it becomes a two-way-mirror that allows Bastian and Atreju to look at each other, and finally it turns into a gate which enables them to live many adventures together. Die unendliche Geschichte can be considered as a modern Bildungsroman in which the young protagonist gradually reaches his maturation. This progress must be seen in a psychological perspective: it is the growth of a child-mind through literature which makes reference to the German novel tradition but also (as children’s literature to the world of unconsciousness.

  12. Michael Mästlin's role in the polemic against the calendar reform of pope Gregor XIII. (German Title: Die Rolle Michael Mästlins in der Polemik um die Kalenderreform von Papst Gregor XIII)

    Science.gov (United States)

    Hamel, Jürgen

    Because of theological resistance, the calendar reform of 1582 was introduced only in countries under catholic rule. Michael Mästlin is found among the spokesmen of opposition against this feared attempted of the pope to gain influence in the protestant church, nevertheless, Mästlin had no doubt that a calendar reform was necessary. This article retraces Mästlin's argumentation and puts it into context with contemporary discussions about a calendar reform.

  13. O que é a Multidão? Questões para Michael Hardt e Antonio Negri

    Directory of Open Access Journals (Sweden)

    Nicholas Brown

    2006-07-01

    Full Text Available Multidão, livro mais recente de Michael Hardt e Antonio Negri, é uma tentativa de nomear e compreender as condições que envolvem a dinâmica social do século xxi. Na entrevista a seguir, Hardt e Negri discorrem sobre as possibilidades de constituição da multidão como agente político, discutem os fundamentos do livro e defendem conceitos que consideram determinantes para a compreensão dos novos tempos, tais como biopolítica e biopoder.Multitude, Michael Hardt and Antonio Negri’s latest book, is an attempt at understanding conditions involving social dynamics in the xxi century. In the interview below, Hardt and Negri consider the constitution of the multitude as a political agent, discuss the structure of their book and support concepts seen as crucial for the comprehension of our time, such as biopolitics and biopower.

  14. Sense and Singularity:Reading Michael Ondaatje's The Collected Works of Billy the Kid

    OpenAIRE

    Spinks, Lee

    2008-01-01

    "Sense and Singularity: Reading Michael Ondaatje's The Collected Works of Billy the Kid" offers a revisionist reading of the style and the politics of both this key long poem and Ondaatje's poetics in general. The article seeks to broaden the critical discussion about Ondaatje's early poetry by claiming that the novelty and force of Billy the Kid inheres in the poet's ability to create a form of minor literature through the event of singularity. The phrase "minor literature" is being employed...

  15. Leadership and creativity in public services: An interview with Lord Michael Bichard, Chair of the National Audit Office

    OpenAIRE

    Bolden, R.; O Regan, N

    2017-01-01

    This interview with Lord Michael Bichard, one of the most distinguished public sector leaders in the UK, explores his ideas around the relationship between leadership, creativity and innovation. A champion of place-based approaches to public services, where citizens are actively involved in service design, delivery and appraisal, Bichard advocates the need for inclusive and supportive leadership that enables the emergence of the kinds of creativity required to respond to the financial challen...

  16. A study on effect of market orientation and Michael Porter's Five Competitive Forces on performance of Bahman Group

    OpenAIRE

    ahra Mohebi Ashtiani; Sharif karimi

    2016-01-01

    Concept of competitive advantage has a direct linkage with the considered values of the customer, such that the more the supplied values of an organization approach to the considered values of the customer in a comparative range, it can say that the organization outperforms the competitors in one or several competitive criteria. The present research is an applied survey which examines effect of market orientation and Michael Porter's Five Competitive Forces on performance of Bahman Group. ...

  17. Application of a Double Aza-Michael Reaction in a ‘Click, Click, Cy-Click’ Strategy: From Bench to Flow

    OpenAIRE

    Zang, Qin; Javed, Salim; Ullah, Farman; Zhou, Aihua; Knudtson, Christopher A.; Bi, Danse; Basha, Fatima Z.; Organ, Michael G.; Hanson, Paul R.

    2011-01-01

    The development of a ‘click, click, cy-click’ process utilizing a double aza-Michael reaction to generate functionalized 1,2,5-thiadiazepane 1,1-dioxides is reported. Optimization in flow, followed by scale out of the inter-/intramolecular double aza-Michael addition has also been realized using a microwave-assisted, continuous flow organic synthesis platform (MACOS). In addition, a facile one-pot, sequential strategy employing in situ Huisgen cycloaddition post-double aza-Michael has been ac...

  18. Asymmetric Michael Addition of Ketones to Nitroolefins Catalyzed by a Novel Chiral Pyrrolidine-Thiourea in the Ionic Liquid

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Jun [Suzhou Univ., Suzhou (China); Chen, Weiyi [J and K Suzhou Ultrafine Material Ltd, Suzhou (China)

    2013-11-15

    A novel chiral pyrrolidine-thiourea has been developed and successfully applied to the asymmetric Michael addition of ketones with nitroolefins in ionic liquid. The corresponding products could be obtained in good yields with good enantio- and diastereoselectivities of products. In addition, the chiral catalytic system could be reused with comparable catalytic activity and stereoselectivity. Further studies are under way to expand the synthetic utility of this new reaction, as well as the application of this catalytic system in other asymmetric transformations. Organocatalytic asymmetric reactions have proved to be efficient and powerful tools in organic synthesis. Among them, the asymmetric Michael reaction of nitroolefins with carbon nucleophiles is widely recognized as one of the most important and versatile processes for the synthesis of enantioselective C-C and C-X bonds; for the nitroolefins are of special interest as excellent Michael acceptors, and the nitro functionality can be easily transformed into an amine, nitrile oxide, ketone, carboxylic acid, hydrogen, etc., providing a wide range of synthetically interesting compounds.

  19. Solid State Ionics: from Michael Faraday to green energy—the European dimension

    Directory of Open Access Journals (Sweden)

    Klaus Funke

    2013-01-01

    Full Text Available Solid State Ionics has its roots essentially in Europe. First foundations were laid by Michael Faraday who discovered the solid electrolytes Ag2S and PbF2 and coined terms such as cation and anion, electrode and electrolyte. In the 19th and early 20th centuries, the main lines of development toward Solid State Ionics, pursued in Europe, concerned the linear laws of transport, structural analysis, disorder and entropy and the electrochemical storage and conversion of energy. Fundamental contributions were then made by Walther Nernst, who derived the Nernst equation and detected ionic conduction in heterovalently doped zirconia, which he utilized in his Nernst lamp. Another big step forward was the discovery of the extraordinary properties of alpha silver iodide in 1914. In the late 1920s and early 1930s, the concept of point defects was established by Yakov Il'ich Frenkel, Walter Schottky and Carl Wagner, including the development of point-defect thermodynamics by Schottky and Wagner. In terms of point defects, ionic (and electronic transport in ionic crystals became easy to visualize. In an 'evolving scheme of materials science', point disorder precedes structural disorder, as displayed by the AgI-type solid electrolytes (and other ionic crystals, by ion-conducting glasses, polymer electrolytes and nano-composites. During the last few decades, much progress has been made in finding and investigating novel solid electrolytes and in using them for the preservation of our environment, in particular in advanced solid state battery systems, fuel cells and sensors. Since 1972, international conferences have been held in the field of Solid State Ionics, and the International Society for Solid State Ionics was founded at one of them, held at Garmisch-Partenkirchen, Germany, in 1987.

  20. Suspense, culpa y cintas de vídeo. Caché/Escondido de Michael Haneke

    Directory of Open Access Journals (Sweden)

    Miguel Martínez-Cabeza

    2011-12-01

    Full Text Available Caché/Escondido (2005 representa dentro de la filmografía de Michael Haneke el ejemplo más destacado de síntesis de los planteamientos formales e ideológicos del cineasta austriaco. Este artículo analiza el filme como manifiesto cinematográfico y como explotación de las convenciones genéricas para construir un modelo de espectador reflexivo. La investigación del modo en que el director plantea y abandona las técnicas del suspense aporta claves para explicar el éxito casi unánime de crítica y la respuesta mucho menos homogénea de las audiencias. El desencadenante de la trama, unas cintas de vídeo que reciben los Laurent, es alusión directa a Carretera Perdida (1997 de David Lynch; no obstante, el misterio acerca del autor de la videovigilancia pierde interés en relación al sentimiento de culpa que desencadena en el protagonista. El episodio infantil de celos y venganza hacia un niño argelino y la actitud del Georges adulto representan una alegoría de la relación de Francia con su pasado colonial que tampoco cierra la narración de Haneke. Es precisamente la apertura formal con que el filme (desestructura cuestiones actuales como el límite entre la responsabilidad individual y colectiva lo que conforma un espectador tan distanciado de la diégesis como consciente de su propio papel de observador.

  1. Corrupting Capitalism: Michael Ende’s Momo and “Cathedral Station”

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    Heike Polster

    2016-01-01

    Full Text Available Michael Ende, the well-known author of The Neverending Story , foresaw dramatic changes in the fabric of society resulting from a turn toward neoliberal policies. One such far-reaching and dangerous change has to do with a diminishing of temporal autonomy, the ability to freely determine the use and meaning of our time. This article explores how neoliberalism is shaping our concept of time and our experience of it. In an effort to demonstrate the process and the line of reasoning behind the monetization of time, and to connect time to more qualitative considerations of the human condition, I shall demonstrate how Ende conceptualizes time as an integral part of the accumulation process of capitalism. I also discuss a fairly cryptic short story, “Cathedral Station,” that envisions “the mystery of money.” Utilizing Walter Benjamin’s critique issued in his 1921 fragment “Capitalism as Religion,” I outline Ende’s dystopian vision of the uncontested, unquestioned reign of capitalism as a religious cult. Read together, the novel and the short story offer a way of contrasting two extreme byproducts of capitalism’s colonization of time, namely what I would call an “ideology of work” and an “ideology of growth.” The first of these is a result of capitalism’s commodification of time according to liberal ideals such as choice, freedom, and self-interest. The second is a decidedly neoliberal phenomenon in that the “financialization of everything,” to use David Harvey’s phrase, results in the ever-present expectation of unlimited, exponential growth. By drawing out these two interconnected ideologies through close readings, the subtle processes of capitalism’s colonization of time are revealed.

  2. Functionalization of Polydopamine via the Aza-Michael Reaction for Antimicrobial Interfaces.

    Science.gov (United States)

    Liu, Chia-Yu; Huang, Chun-Jen

    2016-05-17

    Polydopamine (pDA) coatings afford tremendous versatility due to their capabilities to provide substrate-independent functionalization with a wide range of amine- and thiol-containing molecules. In this work, we developed a new and facile conjugation approach to the formation of β-amino carbonyl linkages between pDA and acrylate/acrylamide molecules via the aza-Michael reaction. Sulfobetaine acrylamide (SBAA), sulfobetaine methacrylate (SBMA), and poly(ethylene glycol) methacrylate (PEGMA) were employed to graft onto pDA films, giving rise to formation of antifouling coatings. Because of the universal adhesive property of pDA, the coating strategy was applied to different substrates, including TiO2, gold, SiO2, Nitinol alloy, polystyrene, and poly(dimethylsiloxane). The variation of surface chemistry and surface wettability upon pDA modification and subsequent conjugation was monitored with X-ray photoelectron spectroscopy (XPS) and water contact angle measurements. Antifouling properties of coatings were challenged by three common Gram-negative and Gram-positive bacteria. Cytocompatibility of the coatings with NIH-3T3 fibroblasts was accessed using MTT assay. The results showed that pDA coatings grafted with SBAA exhibited superhydrophilicity and excellent fouling resistance likely due to the high chemical reactivity of acrylamide, leading to high grafting density. In addition, dual functional coatings containing passive and active antibacterial components were constructed through the in situ deposition of antimicrobial agent, silver nanoparticles, in pDA, followed by the grafting of SBAA for bacterial repellence. The composite coatings allowed reducing adsorption of E. coli by >95%, while killing attached bacteria by up to 98% upon the releasing of Ag(+) ions as measured by inductively coupled plasma mass spectrometry. Consequently, this work paves a new avenue to the grafting strategy to engineer pDA and to the functional bioinspired antifouling interfaces in

  3. Analysis of Media Stereotypes of the Russian Image in Media Studies in the Student Audience (example: the screen versions of Jules Verne's Novel “Michael Strogoff”)

    National Research Council Canada - National Science Library

    Alexander Fedorov

    2014-01-01

    As a result of the analysis students come to the conclusion that the screen adaptations of Jules Verne's novel ''Michael Strogoff'' create, though an oversimplified and adapted to western stereotype...

  4. Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-Pot Sulfonylation/Thia-Michael Protocol

    OpenAIRE

    Zang, Qin; Zhou, Aihua; Javed, Salim; Maity, Pradip K.; Knudtson, Chris A.; Bi, Danse; Hastings, Jared J.; Basha, Fatima Z.; Hanson, Paul R.

    2012-01-01

    A novel one-pot sulfonylation/intramolecular thia-Michael protocol is reported for the synthesis of 1,5,2-dithiazepine 1,1-dioxides. Sulfonylation between cysteine ethyl ester/cysteamine and 2-chloroethanesulfonyl chloride, followed by in situ intramolecular thia-Michael addition, was achieved and afforded the titled 1,5,2-dithiazepine-1,1-dioxide scaffolds. Diversification was demonstrated for future library synthesis.

  5. New eco-friendly animal bone meal catalysts for preparation of chalcones and aza-Michael adducts

    Directory of Open Access Journals (Sweden)

    Riadi Yassine

    2012-06-01

    Full Text Available Abstract Two efficient reactions were successfully carried out using Animal Bone Meal (ABM and potassium fluoride or sodium nitrate doped ABMs as new heterogeneous catalysts under very mild conditions. After preparation and characterization of the catalysts, we first report their use in a simple and convenient synthesis of various chalcones by Claisen–Schmidt condensation and then in an aza-Michael addition involving several synthesized chalcones with aromatic amines. All the reactions were carried out at room temperature in methanol; the chalcone synthesis was also achieved in water environment under microwave irradiation. Doping ABM enhances the rate and yield at each reaction. Catalytic activities are discussed and the ability to re-use the ABM is demonstrated. Results For Claisen–Schmidt the use of ABM alone, yields never exceeded 17%. In each entry, KF/ABM and NaNO3/ABM (79-97% gave higher yields than using ABM alone under thermic condition. Also the reaction proceeded under microwave irradiation in good yields (72-94% for KF/ABM and 81-97% for NaNO3/ABM and high purity. For aza-Michael addition the use of ABM doped with KF or NaNO3 increased the catalytic activity remarkably. The very high yields could be noted (84-95% for KF/ABM and 81-94% for NaNO3/ABM. Conclusion The present method is an efficient and selective procedure for the synthesis of chalcones an aza-Michael adducts. The ABM and doped ABMs are a new, inexpensive and attractive solid supports which can contribute to the development of catalytic processes and reduced environmental problems.

  6. Asymmetric Copper-Catalyzed Vinylogous Mukaiyama Michael Addition of Cyclic Dienol Silanes to Unsaturated α-Keto Phosphonates.

    Science.gov (United States)

    Steinkamp, Anne-Dorothee; Frings, Marcus; Thomé, Isabelle; Schiffers, Ingo; Bolm, Carsten

    2015-05-18

    A highly stereoselective vinylogous Mukaiyama Michael reaction (VMMR) leading to α-keto phosphonate-containing γ-butenolides with two stereogenic centers is described. The presented transformation is catalyzed by a combination of a commercially available C2 -symmetric bisoxazoline (BOX) ligand and a copper salt and tolerates a variety of nucleophiles and electrophiles. The stereoselectivities of the reactions are good to excellent and the products are obtained in moderate to high yields. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Enantioselective Michael Addition of Cyclic β-Diones to α,β-Unsaturated Enones Catalyzed by Quinine-Based Organocatalysts

    Directory of Open Access Journals (Sweden)

    Qingqing Wang

    2017-06-01

    Full Text Available An enantioselective (52–98% ee Michael addition between cyclic β-diones and α,β-unsaturated enones was established in the presence of quinine-based primary amine or squaramide. A variety of cinnamones were smoothly converted into the desired 3,4-dihydropyrans in moderate to high yields (63–99%. Chalcones were also suitable acceptors and gave rise to the expected adducts in satisfactory yields (31–99%. The resulting adducts readily underwent further modification to form fused 4H-pyran or 2,3-dihydrofuran.

  8. Advances in Statistical Control, Algebraic Systems Theory, and Dynamic Systems Characteristics A Tribute to Michael K Sain

    CERN Document Server

    Won, Chang-Hee; Michel, Anthony N

    2008-01-01

    This volume - dedicated to Michael K. Sain on the occasion of his seventieth birthday - is a collection of chapters covering recent advances in stochastic optimal control theory and algebraic systems theory. Written by experts in their respective fields, the chapters are thematically organized into four parts: Part I focuses on statistical control theory, where the cost function is viewed as a random variable and performance is shaped through cost cumulants. In this respect, statistical control generalizes linear-quadratic-Gaussian and H-infinity control. Part II addresses algebraic systems th

  9. Kochin, Michael S. 2009. Five Chapters on Rhetoric: Character, Action, Things, Nothing and Art (University Park: Pennsylvania State University Press

    Directory of Open Access Journals (Sweden)

    Eithan Orkibi

    2010-04-01

    Full Text Available Deux constatations traversent le nouvel ouvrage de Michael Kochin, et nous invitent à reconsidérer la rhétorique dans la communication persuasive. D’abord, que ce sont les événements concrets et les faits mis à l’épreuve qui ont la plus grande force de conviction ; et ensuite, que le discours a souvent une fonction autre que la persuasion : celle de maintenir les canaux de communication pour sauvegarder les relations et les institutions humaines. Pour l’auteur de cet ouvrage qui porte sur les...

  10. A propósito del libro "Accounting theory: research, regulation and accounting practice" de Michael Gaffikin

    Directory of Open Access Journals (Sweden)

    Garcia Nohora

    2012-09-01

    Full Text Available En el libro “Accounting theory: research, regulation and accounting practice”, el profesor australiano Michael Gaffikin ofrece al lector una idea del origen y amplio desenvolvimiento de la teoría contable durante el siglo XX “cuyo desarrollo ha sido dominado por Estados Unidos” (Gaffikin, 2008, p. 32. Plantea, igualmente, los desafíos y problemas actuales de la regulación y la profesión contable. Por ejemplo, el autor precisa que ante la incapacidad de lograr un acuerdo sobre las mediciones apropiadas, la tendencia mundial es a instaurar medidas determinadas arbitrariamente (Gaffikin, 2008, p. 154.

  11. Dipeptide-Derived Multifunctional Quaternary Phosphonium Salt Catalyzed Asymmetric Cyclizations via a Tandem Michael Addition/SN 2 Sequence.

    Science.gov (United States)

    Cao, Dongdong; Zhang, Jiaxing; Wang, Hongyu; Zhao, Gang

    2015-07-06

    A novel family of dipeptide-based multifunctional quaternary phosphonium salts has been developed as chiral phase-transfer catalysts, which feature ready accessibility and structure modularity, allowing easy fine-tunings of activity. They demonstrated high efficiency in catalyzing the tandem asymmetric Michael addition/intramolecular SN 2 reaction between 6 or 7-substituted conjugate enones and malonates, providing synthetically important five or six-membered carbocycles and heterocycles in good yields and with good to excellent enantioselectivities. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Kinetic study of electrochemically induced michael reactions of o-quinones with Meldrum's acid derivatives. Synthesis of highly oxygenated catechols.

    Science.gov (United States)

    Nematollahi, D; Shayani-jam, H

    2008-05-02

    Electrochemical oxidation of catechols has been studied in the presence of Meldrum's acid derivatives as nucleophiles in aqueous solution, by means of cyclic voltammetry and controlled-potential coulometry. Catechols in the Michael addition reaction react with Meldrum's acids to form adducts that can undergo electrooxidation. Such products were obtained in good yields as confirmed by controlled potential electrosynthesis. Such products can be generated in aqueous solutions by means of electrosynthesis, using a carbon electrode in an undivided cell. Furthermore, the homogeneous rate constants of the chemical reaction interposed between electron transfers were estimated by comparing the experimental cyclic voltammetric curves with the digitally simulated ones.

  13. Michael additions of thiocompounds to {alpha}, {beta}-unsaturated carbonyl compounds in aqueous media: stereoselectivity with unambiguous characterization by NMR

    Energy Technology Data Exchange (ETDEWEB)

    Almeida, Queli Aparecida Rodrigues de; Pereira, Maria Luiza de Oliveira; Coelho, Ricardo Bezerra; Kaiser, Carlos Roland; Jones Junior, Joel; Silva, Flavia Martins da [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Inst. de Quimica. Dept. de Quimica Organica]. E-mail: soa@iq.ufrj.br; Carvalho, Erika Martins de [Instituto de Tecnologia em Farmacos (Far-Manguinhos), Rio de Janeiro, RJ (Brazil)

    2008-07-01

    The reactions of crotonaldehyde (8) with thiophenol (2) and benzalacetone (10) with ethane-1,2- dithiol (11) yield Michael addition products. The reactions of thiophenol (2) with (R)-carvone (13) and (S)-perillaldehyde (15) lead to (2S,3R,5S)-5-isopropenyl-2-methyl-3-(phenylthio)cyclohexanone (14) and (1R,2R,4S)-4-isopropenyl-2-(phenylthio)cyclohexanecarbaldehyde (16), respectively. An unambiguous elucidation of the stereochemistry of 14 and 16 by NMR is also presented. (author)

  14. Sexuality degree zero: pleasure and power in the novels of John Rechy, Arturo Islas, and Michael Nava.

    Science.gov (United States)

    Ortiz, R L

    1993-01-01

    "Sexuality Degree Zero" explores common themes and formal strategies in the fiction of three prominent gay Chicano writers: John Rechy, Arturo Islas, and Michael Nava. Employing the concept of a politicized textual "pleasure" as theorized by French critic Roland Barthes, the study argues for the political efficacy of aesthetic choices characteristic to the three authors. Analyses of Rechy's use of pornography, of Islas' transgressive use of cultural iconography, and of Nava's use of sexual "perversions" in the context of classic crime fiction, all go to demonstrate the various uses of pleasure in the construction of a doubly marginalized but defiant self and voice in fiction by gay Chicano men.

  15. Refined transition-state models for proline-catalyzed asymmetric Michael reactions under basic and base-free conditions.

    Science.gov (United States)

    Sharma, Akhilesh K; Sunoj, Raghavan B

    2012-12-07

    The stereocontrolling transition state (TS) models for C-C bond formation relying on hydrogen bonding have generally been successful in proline-catalyzed aldol, Mannich, α-amination, and α-aminoxylation reactions. However, the suitability of the hydrogen-bonding model in protic and aprotic conditions as well as under basic and base-free conditions has not been well established for Michael reactions. Through a comprehensive density functional theory investigation, we herein analyze different TS models for the stereocontrolling C-C bond formation, both in the presence and absence of a base in an aprotic solvent (THF). A refined stereocontrolling TS for the Michael reaction between cyclohexanone and nitrostyrene is proposed. The new TS devoid of hydrogen bonding between the nitro group of nitrostyrene and carboxylic acid of proline, under base-free conditions, is found to be more preferred over the conventional hydrogen-bonding model besides being able to reproduce the experimentally observed stereochemical outcome. A DBU-bound TS is identified as more suitable for rationalizing the origin of asymmetric induction under basic reaction conditions. In both cases, the most preferred approach of nitrostyrene is identified as occurring from the face anti to the carboxylic acid of proline-enamine. The predicted enantio- and diastereoselectivities are in very good agreement with the experimental observations.

  16. Trajetória acadêmica e perspectivas acerca do turismo sob o olhar de Colin Michael Hall

    Directory of Open Access Journals (Sweden)

    Elayne Gouveia da Silva

    2016-04-01

    Full Text Available Este trabalho versa sobre a visão do Colin Michael Hall na temática do turismo. Para analisar essa temática imbricou-se em duas leituras principais como parâmetro para a discussão. A primeira é a obra “Planejamento turístico: política, processo e planejamento” e, a segunda, “Turismo como El Ciencia Social de La Movilidade”. Estas obras marcam a mudança de visão do autor, onde o mesmo se dedica a fomentar um novo olhar sobre o turismo suscitando sete aspectos para se pensar no turismo. O objetivo deste artigo é analisar a visão de Colin Michael Hall acerca do Turismo. Como metas intermediárias pretende-se, a partir da compilação de informações sobre sua vida acadêmica e suas principais contribuições realizar uma breve crítica. Para o trabalho utilizou-se a pesquisa bibliográfica, e entrevista com o autor. Como resultado obteve-se uma reunião das principais ideias e posições ideológicas do autor, e algumas de suas contribuições com o estudo do turismo.

  17. A colorimetric detection of acrylamide in potato chips based on nucleophile-initiated thiol-ene Michael addition.

    Science.gov (United States)

    Hu, Qinqin; Fu, Yingchun; Xu, Xiahong; Qiao, Zhaohui; Wang, Ronghui; Zhang, Ying; Li, Yanbin

    2016-02-07

    Acrylamide (AA), a neurotoxin and a potential carcinogen, has been found in various thermally processed foods such as potato chips, biscuits, and coffee. Simple, cost-effective, and sensitive methods for the rapid detection of AA are needed to ensure food safety. Herein, a novel colorimetric method was proposed for the visual detection of AA based on a nucleophile-initiated thiol-ene Michael addition reaction. Gold nanoparticles (AuNPs) were aggregated by glutathione (GSH) because of a ligand-replacement, accompanied by a color change from red to purple. In the presence of AA, after the thiol-ene Michael addition reaction between GSH and AA with the catalysis of a nucleophile, the sulfhydryl group of GSH was consumed by AA, which hindered the subsequent ligand-replacement and the aggregation of AuNPs. Therefore, the concentration of AA could be determined by the visible color change caused by dispersion/aggregation of AuNPs. This new method showed high sensitivity with a linear range from 0.1 μmol L(-1) to 80 μmol L(-1) and a detection limit of 28.6 nmol L(-1), and especially revealed better selectivity than the fluorescence sensing method reported previously. Moreover, this new method was used to detect AA in potato chips with a satisfactory result in comparison with the standard methods based on chromatography, which indicated that the colorimetric method can be expanded for the rapid detection of AA in thermally processed foods.

  18. Jane Eyre de Michael Berkeley et de David Malouf : La transposition opératique d’un grand classique de la littérature anglaise Jane Eyre by Michael Berkeley and David Malouf: The Operatic Rewriting of a Great Classic English Novel

    National Research Council Canada - National Science Library

    Jean-Philippe Héberlé

    2009-01-01

    This article discusses Michael Berkeley’s opera Jane Eyre. Premiered on June 30, 2000 by Music Theatre Wales at the Cheltenham International Festival of Music, this opera is based on the novel by Charlotte Brontë...

  19. A facile and efficient method of enzyme immobilization on silica particles via Michael acceptor film coatings: immobilized catalase in a plug flow reactor.

    Science.gov (United States)

    Bayramoglu, Gulay; Arica, M Yakup; Genc, Aysenur; Ozalp, V Cengiz; Ince, Ahmet; Bicak, Niyazi

    2016-06-01

    A novel method was developed for facile immobilization of enzymes on silica surfaces. Herein, we describe a single-step strategy for generating of reactive double bonds capable of Michael addition on the surfaces of silica particles. This method was based on reactive thin film generation on the surfaces by heating of impregnated self-curable polymer, alpha-morpholine substituted poly(vinyl methyl ketone) p(VMK). The generated double bonds were demonstrated to be an efficient way for rapid incorporation of enzymes via Michael addition. Catalase was used as model enzyme in order to test the effect of immobilization methodology by the reactive film surface through Michael addition reaction. Finally, a plug flow type immobilized enzyme reactor was employed to estimate decomposition rate of hydrogen peroxide. The highly stable enzyme reactor could operate continuously for 120 h at 30 °C with only a loss of about 36 % of its initial activity.

  20. A study of the sequential Michael addition-ring closure reaction of ethyl acetoacetate with chalcone: influence of quaternary ammonium cations as phase transfer catalysts

    Energy Technology Data Exchange (ETDEWEB)

    Lopes, Regina C.V.; Oliveira, Maria da Conceicao F. de; Lemos, Telma L.G. de; Mattos, Marcos C. de [Universidade Federal do Ceara, Fortaleza, CE (Brazil). Dept. de Quimica Organica e Inorganica]. E-mail: mcdmatto@ufc.br

    2005-09-15

    The Michael addition of ethyl acetoacetate 1 to chalcone 2 under Solid/Liquid Phase Transfer Catalysis (SL-PTC), solvent free, afforded Michael adduct 3 and an annulated compound 4 in good yield. The cyclic compound 4 was obtained in the majority via an annulation process of the Michael adduct 3. The proportion of 4 in the ratio of 3/4 was dependant on the structure of the quaternary ammonium cation. The results were interpreted on the basis of the organophilicity and accessibility of the catalysts as well as by invoking a 6-membered ring transition state for the formation of 4 due to the chelation level with Q{sup +}. (author)

  1. Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases. Part 3: Michael addition reactions and miscellaneous transformations.

    Science.gov (United States)

    Aceña, José Luis; Sorochinsky, Alexander E; Soloshonok, Vadim

    2014-09-01

    The major goal of this review is a critical discussion of the literature data on asymmetric synthesis of α-amino acids via Michael addition reactions involving Ni(II)-complexes of amino acids. The material covered is divided into two conceptually different groups dealing with applications of: (a) Ni(II)-complexes of glycine as C-nucleophiles and (b) Ni(II)-complexes of dehydroalanine as Michael acceptors. The first group is significantly larger and consequently subdivided into four chapters based on the source of stereocontrolling element. Thus, a chiral auxiliary can be used as a part of nucleophilic glycine Ni(II) complex, Michael acceptor or both, leading to the conditions of matching vs. mismatching stereochemical preferences. The particular focus of the review is made on the practical aspects of the methodology under discussion and mechanistic considerations.

  2. Invited Commentary: Continuing to Loosen the Constraints on Epidemiology in an Age of Change-A Comment on McMichael's "Prisoners of the Proximate".

    Science.gov (United States)

    Galea, Sandro

    2017-06-01

    Published in 1999, McMichael's "Prisoners of the Proximate: Loosening the Constraints on Epidemiology in an Age of Change" (Am J Epidemiol. 1999;149(10):887-897) outlined an exciting vision for epidemiology as the field that that can help us better understand the drivers of population health so that we may intervene, paving the way for healthier populations. McMichael's paper remains today what it was when it was first published: clear, thoughtful, provocative, and usefully prescriptive in its call to action. McMichael identified 4 constraints facing epidemiology. The field has risen to this challenge and addressed some of these constraints. I discuss how successful (or not) we have been in addressing each of these 4 challenges. © The Author 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. L’impérialisme humanitaire de Michael Ignatieff : le cas d’un « liberal hawk » Michael Ignatieff’s “Humanitarian Imperialism”: The case of a “liberal hawk”

    Directory of Open Access Journals (Sweden)

    Pierre Guerlain

    2009-10-01

    Full Text Available Michael Ignatieff, a former Harvard professor who is now active in Canadian politics, represents a school of thought which may be called humanitarian imperialism or liberal imperialism whose most famous representative in Europe is Bernard Kouchner. He argues for US interventions in the world (Kosovo, Afghanistan, Iraq on account of UN weakness and unwillingness to stop massacres or genocides. In his calls for the US to assume this new burden, Ignatieff mentions all the arguments usually invoked against empires and imperialism only to reject them in a rhetorical twist. He is one of the most articulate advocates of military intervention with a clear conscience. Though he often ends up in agreement with neoconservative or neoliberal imperialists his justifications are more intellectual and convoluted and therefore address a different audience.

  4. Tetrabutylammonium Bromide Media Aza-Michael Addition of 1,2,3,6-Tetrahydrophthalimide to Symmetrical Fumaric Esters and Acrylic Esters under Solvent-Free Conditions

    Directory of Open Access Journals (Sweden)

    Mohammadreza Zamanloo

    2010-10-01

    Full Text Available The aza-Michael addition of 1,2,3,6-tetrahydrophthalimide with symmetrical fumaric esters has been performed efficiently in a solvent-free system at 100 °C and using 1,4-diazabicyclo[2.2.2]octane (DABCO as a base in the presence of tetrabutylammonium bromide (TBAB. The products were obtained in good to high yields within 2.5-7.0 h. This reaction worked well on linear alkyl fumarates and was not effective with nonlinear alkyl fumarates. Although the reaction was also applicable to acrylates such as n-butyl acrylate, methacrylates and crotonates were not suitable Michael acceptors for this reaction.

  5. ‘Introducing Michael Gove to Loïc Wacquant’: Why Social Work Needs Critical Sociology

    Science.gov (United States)

    Michael Garrett, Paul

    2016-01-01

    In 2013, Michael Gove, then Secretary of State for Education and Health in the UK coalition government, criticised social workers for laying insufficient emphasis on the ‘agency’ of individuals and for being too preoccupied with social and economic inequalities. Such a perspective, which is not unique to Gove, needs to be countered by reaffirming the significance of an expansively critical sociology for social work. In this context, the thematic concerns of the French theorist, Loïc Wacquant, illuminates key aspects of social work engagement with clients which Gove and his ideological associates appear intent on ignoring. The issues raised have significant political resonances given the pending UK General Election taking place in May 2015. PMID:27559203

  6. WHEN DYLAN MET THE BARD: TRANSLATING HAMLET FROM TEXT TO SCREEN (SOUND: MICHAEL ALMEREYDA’S HAMLET

    Directory of Open Access Journals (Sweden)

    Marina Gerzic

    2015-12-01

    Full Text Available Director Michael Almereyda’s diverse musical choices in the film are a threshold into understanding his cinematic interpretation of Hamlet (2000. Almereyda recontextualises Hamlet in terms of contemporary social problems. Hamlet and Ophelia are confronted with and battle against urban claustrophobia, conspiracy and global corporate power. A fragment of the Bob Dylan song ‘All Along the Watchtower’ (1966 is used as a filmic shortcut to translate Shakespeare’s iconic ‘gravedigger scene’ between Hamlet and the Gravedigger from playtext to screen. ‘All Along the Watchtower’ encapsulates certain ideas about mortality and the worth of life from the ‘gravedigger scene’ and demonstrates these issues still resonate in the contemporary urban world the film is set.

  7. Switchable Diastereoselectivity in the Fluoride Promoted Vinylogous Mukaiyama-Michael Reaction of 2-Trimethylsilyloxyfuran Catalyzed by Crown Ethers

    KAUST Repository

    Della Sala, Giorgio

    2017-05-31

    The fluoride promoted vinylogous Mukaiyama-Michael reaction (VMMR) of 2-trimethylsilyloxyfuran with diverse α,β-unsaturated ketones is described. The TBAF catalyzed VMMR afforded high anti-diastereoselectivity irrespective of the solvents used. The KF/crown ethers catalytic systems proved to be highly efficient in terms of yields and resulted in a highly diastereoselective unprecedented solvent/catalyst switchable reaction. Anti-adducts were obtained as single diastereomers or with excellent diastereoselectivities when benzo-15-crown-5 in CH2Cl2 was employed. On the other hand, high syn-diastereoselectivities (from 76:24 to 96:4) were achieved by employing dicyclohexane-18-crown-6 in toluene. Based on DFT calculations, the catalysts/solvents-dependent switchable diastereoselectivities are proposed to be the result of loose or tight cation-dienolate ion pairs.

  8. Book Review: Michael Baun and Dan Marek (eds. The New Member States and the European Union. Foreign Policy and Europeanization

    Directory of Open Access Journals (Sweden)

    Adelin Dumitru

    2014-09-01

    Full Text Available A radical decision at the time, the 2004 enlargement constituted a critical juncture for the Central and Eastern European Countries. Although a great deal of literature has been written in regard to other aspects of Europeanization, the effects of EU membership on the foreign policy of the new member states have been rarely discussed. This is what the volume coordinated by Michael Baun and Dan Marek seeks to accomplish, namely to fill a gap in the European Studies with a series of articles explaining the more or less significant institutional and behavioural changes which occurred at the level of the new member states’ political elites. Focusing on three main domains in which Europeanization purportedly occurred, namely national preferences and interests, institutions and procedures, foreign policy strategies and actions, the studies gathered in this volume provide a useful overview of the effects of EU membership on what was traditionally known as “foreign policy”.

  9. Enzyme-catalyzed Michael addition for the synthesis of warfarin and its determination via fluorescence quenching of L-tryptophan

    Science.gov (United States)

    Yuan, Yusheng; Yang, Liu; Liu, Shaopu; Yang, Jidong; Zhang, Hui; Yan, Jingjing; Hu, Xiaoli

    2017-04-01

    A sensitive fluorescence sensor for warfarin was proposed via quenching the fluorescence of L-tryptophan due to the interaction between warfarin and L-tryptophan. Warfarin, as one of the most effective anticoagulants, was designed and synthesized via lipase from porcine pancreas (PPL) as a biocatalyst to catalyze the Michael addition of 4-hydroxycoumarin to α, β-unsaturated enones in organic medium in the presence of water. Furthermore, the spectrofluorometry was used to detect the concentration of warfarin with a linear range and detection limit (3σ/k) of 0.04-12.0 μmol L- 1 (R2 = 0.994) and 0.01 μmol L- 1, respectively. Herein, this was the first application of bio-catalytic synthesis and fluorescence for the determination of warfarin. The proposed method was applied to determine warfarin of the drug in tablets with satisfactory results.

  10. Michael Camille, The Gargoyles of Notre-Dame: Medievalism and the Monsters of Modernity, Chicago, University of Chicago Press, 2009

    OpenAIRE

    Le Pogam, Pierre-Yves

    2013-01-01

    Il s’agit du dernier livre de Michael Camille, paru à titre posthume (et malgré cette difficulté, l’ouvrage est d’une très grande qualité éditoriale, seules quelques notes bibliographiques étant restées inachevées). Il faut rendre hommage à la fois aux amis et collègues de Camille d’avoir permis la publication d’un livre important et surtout à l’auteur lui-même qui, après sa disparition, nous livre encore un nouvel exemple de ses réflexions si stimulantes pour les médiévistes. Ici, Camille ab...

  11. The cultural evolution of language and brain: Comment on "Towards a Computational Comparative Neuroprimatology: Framing the language-ready brain" by Michael A. Arbib

    Science.gov (United States)

    Colagè, Ivan

    2016-03-01

    Michael A. Arbib's Mirror System Hypothesis (MSH) [1,2] is among the most elaborate attempts at disentangling the issue of language origin. I will focus on the role that cultural evolution, as distinct from biological (genetic) evolution, may have played in the emergence of ;modern; human language (as contrasted with forms of proto-languages).

  12. Preparation of a Rapidly Forming Poly(ferrocenylsilane)-Poly(ethylene glycol)-based Hydrogel by a Thiol–Michael Addition Click Reaction

    NARCIS (Netherlands)

    Sui, Xiaofeng; van Ingen, Lennard; Hempenius, Mark A.; Vancso, Gyula J.

    2010-01-01

    The synthesis of a rapidly forming redox responsive poly(ferrocenylsilane)-poly(ethylene glycol) (PFS-PEG)-based hydrogel is described, achieved by a thiol-Michael addition click reaction. PFS bearing acrylate side groups (PFS-acryl) was synthesized by side group modification of

  13. Aza‐Michael addition reaction: Post‐polymerization modification and preparation of PEI/PEG‐based polyester hydrogels from enzymatically synthesized reactive polymers

    DEFF Research Database (Denmark)

    Hoffmann, Christian; Stuparu, Mihaiela C.; Daugaard, Anders Egede

    2015-01-01

    The utility of aza‐Michael addition chemistry for post‐polymerization functionalization of enzymatically prepared polyesters is established. For this, itaconate ester and oligoethylene glycol are selected as monomers. A Candida Antarctica lipase B catalyzed polycondensation reaction between the t...

  14. Using Our Voices, Losing Our Bodies: Michael Brown, Trayvon Martin, and the Spirit Murders of Black Male Professors in the Academy

    Science.gov (United States)

    Johnson, Lamar; Bryan, Nathaniel

    2017-01-01

    The recent deaths of Michael Brown, Trayvon Martin, and other Black males have generated new civil rights urgencies in Black communities and spirited academic discourses in higher education regarding the educational and social plight of Black males in America. Connecting the deaths of Black males to our lived experiences in the academy, we use a…

  15. Synthesis of new pyrrolidine-based organocatalysts and study of their use in the asymmetric Michael addition of aldehydes to nitroolefins

    Directory of Open Access Journals (Sweden)

    Alejandro Castán

    2017-03-01

    Full Text Available New pyrrolidine-based organocatalysts with a bulky substituent at C2 were synthesized from chiral imines derived from (R-glyceraldehyde acetonide by diastereoselective allylation followed by a sequential hydrozirconation/iodination reaction. The new compounds were found to be effective organocatalysts for the Michael addition of aldehydes to nitroolefins and enantioselectivities up to 85% ee were achieved.

  16. Catalytic asymmetric conjugate addition of isocyanoacetate to (Z)-3-substituted-2-(4-pyridyl)-acrylonitrile, a reactive class of Michael acceptor.

    Science.gov (United States)

    Del Fiandra, Claudia; Moccia, Maria; Cerulli, Valentina; Adamo, Mauro F A

    2016-01-28

    (Z)-3-Substituted-2-(4-pyridyl)-acrylonitriles, a reactive class of Michael acceptors obtained exclusively as a single (Z) isomer, reacted with un-substituted isocyanoacetate esters mediated by phase-transfer catalysis to give, after base promoted cyclisation, functionalized imines in up to 94% ee and as a single diastereoisomer.

  17. LEBANON AFTER THE CEDAR REVOLUTION/ARE KNUDSEN AND MICHAEL KERR (eds; LEBANON: A HISTORY, 600--2011/by WILLIAM HARRIS

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    Franck Salameh

    2013-05-01

    Full Text Available LEBANON AFTER THE CEDAR REVOLUTION, ARE KNUDSEN AND MICHAEL KERR (eds; London: C. Hurst & Company, 2012. 323 pp. $29.95. LEBANON: A HISTORY, 600--2011, WILLIAM HARRIS; Oxford, New York: Oxford University Press, 2012. 360 pp. $34.95.

  18. Asymmetric Diels Alder reactions and Michael type additions with 6(R)-3’(R)-Pantolactone-substituted-2H-Pyran-3(6H)-one.

    NARCIS (Netherlands)

    Knol, Joop; Jansen, Johan F.G.A.; Bolhuis, Fré van; Feringa, Bernard

    1991-01-01

    The preparation of optically pure pyranone 2a, using d-pantolactone as a chiral auxiliairy, and its successful application in Diels Alder and Michael type additions with d.r.’s of 89/11 up to 100/0 is described.

  19. ASYMMETRIC DIELS-ALDER REACTIONS AND MICHAEL TYPE ADDITIONS WITH 6(R)-3'-(R)-PANTOLACTONE-SUBSTITUTED-2H-PYRAN-3(6H)-ONE

    NARCIS (Netherlands)

    KNOL, J; JANSEN, JFGA; VANBOLHUIS, F; FERINGA, BL

    1991-01-01

    The preparation of optically pure pyranone 2a, using d-pantolactone as a chiral auxiliairy, and its successful application in Diels Alder and Michael type additions with d.r.'s of 89/11 up to 100/0 is described.

  20. Domino Aza-Michael-ih-Diels-Alder Reaction to Various 3-Vinyl-1,2,4-triazines: Access to Polysubstituted Tetrahydro-1,6-naphthyridines.

    Science.gov (United States)

    Jouha, Jabrane; Buttard, Floris; Lorion, Magali; Berthonneau, Clément; Khouili, Mostafa; Hiebel, Marie-Aude; Guillaumet, Gérald; Brière, Jean-François; Suzenet, Franck

    2017-09-15

    A straightforward domino aza-Michael-inverse-electron-demand-hetero-Diels-Alder/retro-Diels-Alder reaction between primary and secondary propargylamine derivatives and 3-vinyl-1,2,4-triazines is developed highlighting not only the uniqueness of this dual-heterocyclic platform but also a novel and unprecedented path to polysubstituted tetrahydro-1,6-naphthyridine scaffolds.

  1. Enantioselective Cu-II-Catalyzed Diels-Alder and Michael Addition Reactions in Water Using Bio-Inspired Triazacyclophane-Based Ligands

    NARCIS (Netherlands)

    Albada, H. Bauke; Rosati, Fiora; Coquiere, David; Roelfes, Gerard; Liskamp, Rob M. J.

    A triazacyclophane (TAC) scaffold decorated with three histidine amino acid residues was used as a tridentate ligand in asymmetric copper(II)-catalysed Diels-Alder and Michael addition reactions in water. Enantiomeric excesses up to 55% were obtained in Diels-Alder reactions using ligands in which

  2. Stereoselective synthesis of organosulfur compounds incorporating N-aromatic heterocyclic motifs and quaternary carbon centers via a sulfa-Michael triggered tandem reaction.

    Science.gov (United States)

    Qin, Tianyou; Cheng, Lu; Zhang, Sean Xiao-An; Liao, Weiwei

    2015-06-14

    A novel sulfa-Michael addition (SMA)-triggered tandem reaction was developed by combining a SMA reaction with a simultaneous rearomatization process utilizing a less reactive carbonyl group as an intramolecular electrophile partner, which provided a unique synthetic route to access various organosulfur compounds incorporating an N-aromatic heterocyclic motif and quaternary carbon centers.

  3. Influencing the nursing commitment to workforce satisfaction and the origins of magnet: an interview with Dr Michael Evans by Jeffrey M. Adams.

    Science.gov (United States)

    Evans, Michael

    2013-10-01

    This department highlights nursing leaders who have demonstrated a commitment to patient care leadership. This interview profiles Michael Evans, PhD, RN, FAAN, dean of the Texas Tech University School of Nursing and president of the American Nurses Credentialing Center.

  4. "Integration was a Solution to Segregation, but Integration does not Address Quality Education": A Conversation about School Desegregation with Dr. Michael A. Middleton

    Science.gov (United States)

    Diem, Sarah; Brooks, Jeffrey

    2013-01-01

    We conclude this special issue reflecting back on the history of desegregation and questioning how we move forward in trying to achieve racially integrated school settings. The epilogue includes a conversation with Dr. Michael A. Middleton, Deputy Chancellor of the University of Missouri-Columbia. Dr. Middleton is an expert in civil rights and…

  5. Synthesis and evaluation of new guanidine-thiourea organocatalyst for the nitro-Michael reaction: Theoretical studies on mechanism and enantioselectivity

    Directory of Open Access Journals (Sweden)

    Tatyana E. Shubina

    2012-09-01

    Full Text Available A new guanidine-thiourea organocatalyst has been developed and applied as bifunctional organocatalyst in the Michael addition reaction of diethyl malonate to trans-β-nitrostyrene. Extensive DFT calculations, including solvent effects and dispersion corrections, as well as ab initio calculations provide a plausible description of the reaction mechanism.

  6. Cadrage, décadrage et recadrage dans Baa Baa Black Sheep : A Jungle Tale de David Malouf et Michael Berkeley Patrimonial Deconstruction and Reconstruction in David Malouf and Michael Berkeley’s Baa Baa Black Sheep : A Jungle Tale

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    Jean-Philippe Héberlé

    2011-11-01

    Full Text Available This article discusses Michael Berkeley’s first opera, Baa Baa Black Sheep: A Jungle Tale. Premiered under the baton of Paul Daniel on July 3rd 1993 at the Cheltenham International Festival of Music, this opera is based on two texts by Rudyard Kipling: The Jungle Books (1894-1895 and “Baa, Baa, Black Sheep” from the short story collection Wee Willie Winkie and Other Stories, first published in 1888. The libretto was penned by the Australian poet, novelist, playwright and librettist, David Malouf. After a brief survey of some of the earliest transpositions of The Jungle Books, I analyse the way David Malouf deals with both texts. “Baa Baa Black Sheep” is used as the central element of his libretto, and episodes and characters from The Jungle Books are incorporated to draw parallelism between the main topics of the two texts. Both Malouf’s endeavour and Berkeley’s, through the music, aims at deconstructing the preposterous oldest transpositions of The Jungle Books and at focusing on the key elements of Kipling’s famous book, notably identity and hybridism, two important themes of colonial and postcolonial literature. The aim of David Malouf and Michael Berkeley is to address an adult audience and show that The Jungle Books are not only aimed at children as Disney’s or Baden Powell’s appropriations of the work could wrongly make us believe.Cet article porte sur Baa Baa Black Sheep: A Jungle Tale, le premier opéra de Michael Berkeley. Créé au Everyman Theatre de Cheltenham le 3 juillet 1993 sous la direction de Paul Daniel, cette œuvre est le fruit de la collaboration entre le compositeur britannique et l’écrivain australien David Malouf. Le livret de Malouf se fonde sur deux récits de Rudyard Kipling : la nouvelle autobiographique “Baa, Baa, Black Sheep” auquel l’opéra doit son nom et The Jungle Books. Après m’être intéressé aux premières transpositions musicales de The Jungle books, je montre comment

  7. El movimiento como simulacro en el mundo virtual: Michael Betancourt y el arte de la inmediatez. = Movement as simulacrum in the virtual world: Michael Betancourt and the art of immediacy

    Directory of Open Access Journals (Sweden)

    José Manuel García Perera

    2016-05-01

    Full Text Available La creación artística se ha acercado en los últimos tiempos a la imagen mediática que propone Internet, alterando sustancialmente una experiencia estética antes basada en el movimiento del espectador en torno a la obra y definida ahora por pantallas que inducen a la pasividad. El trabajo en vídeo de Michael Betancourt, encuadrado en el denominado arte glitch, ese que se fija en el fallo ocurrido dentro del ámbito digital, ha sido la base para realizar aquí un estudio comparativo entre diferentes concepciones artísticas del movimiento, así como entre un arte pasado y otro actual que permite ver cómo los avances tecnológicos han originado cambios radicales en la naturaleza corpórea, espacial y móvil de la obra. La investigación de Betancourt propone un nuevo arte cinético que, por medio del error, se hace crítico, se mimetiza con el movimiento en tiempo real que la contemporaneidad demanda y destapa el artificio de imágenes que imitan a la realidad como si quisieran sustituirla.In recent times, artistic creation has come closer to the media image proposed by Internet, thus seriously altering an aesthetic experience based before on movement of the viewer around the work and now defined by screens that induce passivity. Michael Betancourt’s video work, part of the so-called glitch art, which focuses on the failure that can occur within the digital realm, has been here the basis for a comparative study between different concepts of movement in art, as well as between a current and a past art, a comparison that allows us to see clearly how technological advances have produced radical changes in the physical, spatial and mobile nature of the artwork. Betancourt’s investigation proposes a new kinetic art that becomes critical through error, mimics the real-time movement that contemporary culture demands, and uncovers the artificiality of images that mimic reality as if they wanted to replace it.

  8. Successful treatment of mild to moderate acne vulgaris with Dr Michaels® (also branded as Zitinex®) topical products family: a clinical trial.

    Science.gov (United States)

    Wollina, U; Tirant, M; Bayer, P; Coburn, M; Anderson, P; Donnelly, B; Kennedy, T; Gaibor, J; Arora, M; Clews, L; Walmsley, S; Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

    2016-01-01

    Acne vulgaris is an epidemic inflammatory skin disease of multi-factorial origin, frequently seen in adolescents and often persisting or occurring through to adulthood. Acne vulgaris is a nearly universal skin disease afflicting 79-95% of the adolescent population in westernized societies and is a significant cause of psychological morbidity in affected patients. Despite the various treatment options available for acne, there is still a need for a safe and effective option. The aim of the study was to investigate the efficacy and tolerability of Dr Michaels® (Zitinex®) product family in the treatment of papulo-pustular acne. 25 patients (17 female/8 male), aged 15-22, with a mild to moderate papulo-pustular acne, localized on the face and on the trunk, were included in this study. None of the patients had used any other kind of treatment in the 3 months prior to commencing this study. All of the patients were treated with Dr Michaels® (Zitinex®) facial exfoliating cleanser, activator formula, a cream, PSC 200 and PSC 900 oral supplements. Application time of Dr Michaels® (Zitinex®) products was 12 weeks. The treatment was been evaluated clinically at 0, 4, 8 and 12 weeks. All of the patients showed an improvement in all parameters of their acne (comedones, papules, pustules, hyperpigmentation and scars). The acne lesions and erythema had mostly resolved. The hyperpigmentation and pitted scarring had significantly reduced also, with the skin appearing smoother. The treatment was well tolerated and no side effects have been described. Our study demonstrates that the Dr Michaels® (Zitinex®) facial exfoliating cleanser, activator formula, cream and oral supplements PSC 200 and PSC 900 are an effective therapeutic option for the treatment of moderately severe acne vulgaris. Moreover, it highlights the safety profile of the Dr Michaels® (Zitinex®) product family in a case of acne compared to traditional first-line treatments.

  9. Examples of weathering and deterioration of Tertiary building stones at St. Michaels Cathedral in Cluj-Napoca (Romania

    Directory of Open Access Journals (Sweden)

    Roman Koch

    2008-10-01

    Full Text Available St. Michaels Cathedral is one of the oldest Gothic architectural monuments in Cluj. It is built predominantly of Cenozoic (Eocene limestones which were deposited on a shallow carbonate platform. They are composed of different facies and microfacies types with varying amounts of particles, matrix and cement. Limestones from the Baci quarry (Cluj Limestone, which is situated about 3 km from the centre of Cluj, were commonly used. The weathering features correspond to the microfacies types, to the position of the stones in the walls and to the exposure (east, south, west, and north, which controls the moisture/dry cycles. This interrelationship is documented by macroscopic and microscopic examples of the decay of samples analyzed from the lower part of the walls. General parameters for a correct classification of carbonate rocks and their importance for weathering are discussed. The general mechanisms of weathering (thermal expansion, water uptake, freezing, chemical weathering are described. The migration of moisture (capillarity and the formation of crusts of varying mineralogy on the surface of building stones are documented. Macroscopic description of damage includes the decay into plates and flakes, the formation of crusts, the formation of fractures, and the growth of lichens and microorganisms. The microscopic analysis documents characteristic damage in detail: fractures parallel to the surface of the stone, internal cementation of fossil chambers (micro-nodules, repeated formation of crusts in varying generations, fracturing in intensively lithified, rigid limestones, and settling of lichens in different positions. Furthermore, different historical mortars and modern “concrete-mortars” and their behaviour in comparison to the adjacent limestones are briefly discussed. The possible conservation and restoration of weathered limestones in St. Michaels Cathedral are discussed with regard to the most recent conservation methods. The

  10. Dr Michaels® product family (also branded as Soratinex®) versus Methylprednisolone aceponate - a comparative study of the effectiveness for the treatment of plaque psoriasis.

    Science.gov (United States)

    Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Wollina, U; Tirant, M; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

    2016-01-01

    As one of the most common dermatologic chronic-recurrent disease, variable therapeutic options are available today for management of psoriasis. Although topical high potency corticosteroids, alone or in association with salicylic acid or vitamin D analogues, are still considered the best treatment, they do not seem to possess the capability for a long-term control of the disease or prevent recurrences, as their side effects are major contraindications for continuative use. The aim of this study was to investigate whether Dr. Michaels® product family is comparable to methylprednisolone aceponate (MPA) as a viable alternative treatment option for the treatment and management of stable chronic plaque psoriasis. Thirty adults (13 male, 17 female, mean age 40 years) with mild to severe stable chronic plaque psoriasis, were included in the study. Patients were advised to treat the lesions of the two sides of their body (left and right) with two different unknown modalities for 8 weeks; the pack of Dr. Michaels® products on the left side (consisting of a cleansing gel, an ointment and a skin conditioner) and a placebo pack on the right side, consisting of a cleansing gel, methylprednisolone ointment and a placebo conditioner. Assessment was done using the Psoriasis Activity Severity Index (PASI) scores before treatment and after 2, 4, 6 and 8 weeks. The results achieved with the Dr. Michaels® (Soratinex®) product family for the treatment of chronic plaque psoriasis were better than the results achieved with methylprednisolone aceponate (MPA), even though quicker resolution was achieved with the steroid with 45% of patients achieving resolution within 8-10 days in comparison to 5-6 weeks in the Dr. Michaels® (Soratinex®) group. Before therapy, the mean PASI score of the LHS in Dr. Michaels® (Soratinex®) group was 13.8±4.1 SD and 14.2±4.2 SD in the RHS methylprednisolone aceponate (MPA) group. After 8 weeks of treatment 62% of the Dr. Michaels® (Soratinex

  11. Quality evaluation of commercially sold table water samples in Michael Okpara University of Agriculture, Umudike, Nigeria and surrounding environments

    Directory of Open Access Journals (Sweden)

    D.O. Okorie

    2015-01-01

    Full Text Available In Michael Okpara University of Agriculture, Umudike, Nigeria (MOUAU and surrounding environments, table water of different brands is commercially hawked by vendors. To the best of our knowledge, there is no scientific documentation on the quality of these water samples. Hence this study which evaluated the quality of different brands of water samples commercially sold in MOUAU and surrounding environments. The physicochemical properties (pH, total dissolved solids (TDS, biochemical oxygen demand (BOD, total hardness, dissolved oxygen, Cl, NO3, ammonium nitrogen (NH3N, turbidity, total suspended solids (TSS, Ca, Mg, Na and K of the water samples as indices of their quality were carried out using standard techniques. Results obtained from this study indicated that most of the chemical constituents of these table water samples commercially sold in Umudike environment conformed to the standards given by the Nigerian Industrial Standard (NIS, World Health Organization (WHO and American Public Health Association (APHA, respectively, while values obtained for ammonium nitrogen in these water samples calls for serious checks on methods of their production and delivery to the end users.

  12. Reaction Mechanism of Organocatalytic Michael Addition of Nitromethane to Cinnamaldehyde: A Case Study on Catalyst Regeneration and Solvent Effects.

    Science.gov (United States)

    Świderek, Katarzyna; Nödling, Alexander R; Tsai, Yu-Hsuan; Luk, Louis Y P; Moliner, Vicent

    2018-01-11

    The Michael addition of nitromethane to cinnamaldehyde has been computationally studied in the absence of a catalyst and the presence of a biotinylated secondary amine by a combined computational and experimental approach. The calculations were performed at the density functional theory (DFT) level with the M06-2X hybrid functional, and a polarizable continuum model has been employed to mimic the effect of two different solvents: dichloromethane (DCM) and water. Contrary to common assumption, the product-derived iminium intermediate was absent in both of the solvents tested. Instead, hydrating the C1-C2 double bond in the enamine intermediate directly yields the tetrahedral intermediate, which is key for forming the product and regenerating the catalyst. Enamine hydration is concerted and found to be rate-limiting in DCM but segregated into two non-rate-limiting steps when the solvent is replaced with water. However, further analysis revealed that the use of water as solvent also raises the energy barriers for other chemical steps, particularly the critical step of C-C bond formation between the iminium intermediate and nucleophile; this consequently lowers both the reaction yield and enantioselectivity of this LUMO-lowering reaction, as experimentally detected. These findings provide a logical explanation to why water often enhances organocatalysis when used as an additive but hampers the reaction progress when employed as a solvent.

  13. Bifunctional Molecular Photoswitches Based on Overcrowded Alkenes for Dynamic Control of Catalytic Activity in Michael Addition Reactions.

    Science.gov (United States)

    Pizzolato, Stefano F; Collins, Beatrice S L; van Leeuwen, Thomas; Feringa, Ben L

    2017-05-02

    The emerging field of artificial photoswitchable catalysis has recently shown striking examples of functional light-responsive systems allowing for dynamic control of activity and selectivity in organocatalysis and metal-catalysed transformations. While our group has already disclosed systems featuring first generation molecular motors as the switchable central core, a design based on second generation molecular motors is lacking. Here, the syntheses of two bifunctionalised molecular switches based on a photoresponsive tetrasubstituted alkene core are reported. They feature a thiourea substituent as hydrogen-donor moiety in the upper half and a basic dimethylamine group in the lower half. This combination of functional groups offers the possibility for application of these molecules in photoswitchable catalytic processes. The light-responsive central cores were synthesized by a Barton-Kellogg coupling of the prefunctionalized upper and lower halves. Derivatization using Buchwald-Hartwig amination and subsequent introduction of the thiourea substituent afforded the target compounds. Control of catalytic activity in the Michael addition reaction between (E)-3-bromo-β-nitrostyrene and 2,4-pentanedione is achieved upon irradiation of stable-(E) and stable-(Z) isomers of the bifunctional catalyst 1. Both isomers display a decrease in catalytic activity upon irradiation to the metastable state, providing systems with the potential to be applied as ON/OFF catalytic photoswitches. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. ANÁLISIS DEL POTENCIAL COMPETITIVO DEL BIOETANOL EN COLOMBIA: UN ENFOQUE DESDE LAS 5 FUERZAS COMPETITIVAS DE MICHAEL PORTER

    Directory of Open Access Journals (Sweden)

    RAMIREZ VELASQUEZ ALEJANDRO

    2012-11-01

    Full Text Available La búsqueda de alternativas de producción y consumo energético requiere una mirada hacia la industria de los combustibles biológicos como el bioetanol que, como alternativa energética, permita superar los inconvenientes generados por los métodos tradicionales de producción y consumo, en especial en los temas políticos, ambientales y sociales y generar ventajas competitivas frente a otras fuentes primarias de energía. En el presente documento,a partir del modelo de las cinco (5 Fuerzas de Michael Porter, se realiza una evaluación de la industria del bioetanol como combustible alternativo y se expone qué tan atractiva o competitiva puede llegar a ser su industria en la actualidad. Para lograr este propósito, se propone una evaluación de las fuerzas competitivas a un panel de expertos, usando escalas deLikert, para encontrar el potencial de la propuesta.

  15. A stale challenge to the philosophy of science: commentary on "Is psychology based on a methodological error?" by Michael Schwarz.

    Science.gov (United States)

    Ruck, Nora; Slunecko, Thomas

    2010-06-01

    In his article "Is psychology based on a methodological error?" and based on a quite convincing empirical basis, Michael Schwarz offers a methodological critique of one of mainstream psychology's key test theoretical axioms, i.e., that of the in principle normal distribution of personality variables. It is characteristic of this paper--and at first seems to be a strength of it--that the author positions his critique within a frame of philosophy of science, particularly positioning himself in the tradition of Karl Popper's critical rationalism. When scrutinizing Schwarz's arguments, however, we find Schwarz's critique profound only as an immanent critique of test theoretical axioms. We raise doubts, however, as to Schwarz's alleged 'challenge' to the philosophy of science because the author not at all seems to be in touch with the state of the art of contemporary philosophy of science. Above all, we question the universalist undercurrent that Schwarz's 'bio-psycho-social model' of human judgment boils down to. In contrast to such position, we close our commentary with a plea for a context- and culture sensitive philosophy of science.

  16. Entrevista com Michael R. KatzDOI: 10.5007/2175-7968.2011v1n27p329

    Directory of Open Access Journals (Sweden)

    Maria Lúcia Barbosa de Vasconcellos

    2011-11-01

    Full Text Available Michael R. Katz graduated from Horace Mann School (New York and attended Williams College (Massachusetts, where he was the very first Russian major. Following graduation in 1966, he studied at Oxford University and the University of Leningrad, where he received his D.Phil. (or Ph.D. in Literature from Oxford. He first taught Russian at Williams and in 1984 became Chair of the Department of Slavic Language and Director of the Title VI Center for Russian and East European Studies at the University of Texas at Austin,. In 1998, he accepted a position as Dean of Language Schools and Schools Abroad at Middlebury College (Vermont. Since his term as Dean ended in 2004, he has been a full-time professor at the Russian Department. Prof. Katz has published several articles on literary translation and written two books. Additionally, he is a published translator of more than a dozen works into English, including novels by Herzen, Chernyshevsky, Dostoevsky, Turgenev, Tolstoy. In this interview, Katz explains how he became a translator, and addresses some important issues concerning the market for translation, his relationship with editors and publishing houses, translation and its critics, and some of the challenges he encountered translating from Russian into English.

  17. Jan Rak and Michael J. Tannenbaum present the book "High-pT physics in the heavy ion era"

    CERN Multimedia

    2013-01-01

    Thursday 13 June 2013 from 4 p.m. to 5 p.m. in the Library, Bldg. 52 1-052 The book provides an overview of the basic concepts of large transverse momentum particle physics, with a focus on pQCD phenomena. It examines high-pT probes of relativistic heavy-ion collisions and will serve as a handbook for those working on RHIC and LHC data analyses. Starting with an introduction and review of the field, the authors look at basic observables and experimental techniques, concentrating on relativistic particle kinematics, before moving onto a discussion about the origins of high-pT physics. The main features of high-pT physics are placed within a historical context and the authors adopt an experimental outlook, highlighting the most important discoveries leading up to the foundation of modern QCD theory. High-pT physics in the heavy ion era, by Jan Rak and Michael J. Tannenbaum,  Cambridge University Press, 2013, ISBN  9780521190299. *Coffee will be served from 3 p.m.*

  18. Inner workings of a cinchona alkaloid catalyzed oxa-Michael cyclization: evidence for a concerted hydrogen-bond-network mechanism.

    Science.gov (United States)

    Hintermann, Lukas; Ackerstaff, Jens; Boeck, Florian

    2013-02-11

    Cinchona alkaloids catalyze the oxa-Michael cyclization of 4-(2-hydroxyphenyl)-2-butenoates to benzo-2,3-dihydrofuran-2-yl acetates and related substrates in up to 99% yield and 91% ee (ee = enantiomeric excess). Catalyst and substrate variation studies reveal an important role of the alkaloid hydroxy group in the reaction mechanism, but not in the sense of a hydrogen-bonding activation of the carbonyl group of the substrate as assumed by the Hiemstra-Wynberg mechanism of bifunctional catalysis. Deuterium labeling at C-2 of the substrate shows that addition of RO-H to the alkenoate occurs with syn diastereoselectivity of ≥99:1, suggesting a mechanism-based specificity. A concerted hydrogen-bond network mechanism is proposed, in which the alkaloid hydroxy group acts as a general acid in the protonation of the α-carbanionic center of the product enolate. The importance of concerted hydrogen-bond network mechanisms in organocatalytic reactions is discussed. The relative stereochemistry of protonation is proposed as analytical tool for detecting concerted addition mechanisms, as opposed to ionic 1,4-additions. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. From defining antigens to new therapies in multiple sclerosis: honoring the contributions of Ruth Arnon and Michael Sela.

    Science.gov (United States)

    Steinman, Lawrence; Shoenfeld, Yehuda

    2014-11-01

    Ruth Arnon and Michael Sela profoundly influenced the development of a model system to test new therapies in multiple sclerosis (MS). Their application of the animal model, known as experimental autoimmune encephalomyelitis (EAE), for the discovery of Copaxone, opened a new path for testing of drug candidates in MS. By measuring clinical, pathologic, and immunologic outcomes, the biological implications of new drugs could be elucidated. Using EAE they established the efficacy of Copaxone as a therapy for preventing and reducing paralysis and inflammation in the central nervous system without massive immune suppression. This had a huge impact on the field of drug discovery for MS. Much like the use of parabiosis to discover soluble factors associated with obesity, or the replica plating system to probe antibiotic resistance in bacteria, the pioneering research on Copaxone using the EAE model, paved the way for the discovery of other therapeutics in MS, including Natalizumab and Fingolimod. Future applications of this approach may well elucidate novel therapies for the neurodegenerative phase of multiple sclerosis associated with disease progression. Copyright © 2014. Published by Elsevier Ltd.

  20. Phosphopeptide characterization by mass spectrometry using reversed-phase supports for solid-phase β-elimination/Michael addition.

    Science.gov (United States)

    Nika, Heinz; Lee, JaeHoon; Willis, Ian M; Angeletti, Ruth Hogue; Hawke, David H

    2012-07-01

    We have adapted the Ba(2+) ion-catalyzed concurrent Michael addition reaction to solid-phase derivatization on ZipTip(C18) pipette tips using 2-aminoethanethiol as a nucleophile. This approach provides several advantages over the classical in-solution-based techniques, including ease of operation, completeness of reaction, improved throughput, efficient use of dilute samples, and amenability to automation. Phosphoseryl and phosphothreonyl peptides, as well as phosphoserine peptides with adjoining prolines, were used to optimize the reaction conditions, which proved highly compatible with the integrity of the samples. The analyte was recovered from the silica-based C18 resin at minimal sample loss. The use of the protocol for improved phosphopeptide detection by signal enhancement was demonstrated with low-level amounts of proteolytic digests from model proteins and experimental samples, an effect found especially prominent with multiple phosphorylated species. The reaction products proved highly suitable for structural characterization by collisionally induced dissociation (CID), and the resultant increased spectral information content, greatly facilitating mapping of the site of phosphorylation. In select cases, the method enables phosphorylation site localization within known protein sequences on the basis of single-stage data alone. The solid-phase strategy presented here provides a simple, versatile, and efficient tool for phosphopeptide structural characterization equipment readily available in most biological laboratories.

  1. DELİLİĞE ÖVGÜ: MICHAEL CHEVAL’İN SARAY SOYTARISI METAFORUNA KARNAVALESK YAKLAŞIM

    Directory of Open Access Journals (Sweden)

    Duygu Ozakin

    2012-08-01

    Full Text Available The folly as a cultural phenomenon plays a symbolic role in social acceptances and art. Reflections of folly in language enable semiotic analysis; however language of fools independent from causuality reverses this interaction benefiting from freedom raised by folly. The relationship established by mental and physical deformations and grotesque appearance between fools and jesters, mimes, jugglers deigns these humiliated groups “Feast of Fools” as a purification ritual in the Middle Ages. However with the Age of Enlightenment a great passion for rationality leads to the idea of capture and rehabilitation of fools.In the study it is aimed to discuss that critical possibilities created by freedom of expression for fools and jesters on the basis of relation between court jester and political power. Reflections of folly in art from the Middle Ages onwards is examined in the case of contemporary surrealist painter Michael Cheval’s “Absurdity” series. Foucault’s “The Great Internment” and Bakhtins’s theory of “Carnival” are used in the study. It is concluded that Cheval makes social criticism by the practice of detournement and thruogh reproduction revitalizes carnivalesque images in his works.

  2. Latter-day Mother Irelands: The Role of Women in Michael Collins and The Wind that Shakes the Barley

    Directory of Open Access Journals (Sweden)

    Pilar Villar-Argáiz

    2007-03-01

    Full Text Available Despite the experimental and subversive work of Irish feminist filmmakers such as Pat Murphy and Margo Harkin in the 1980s, as Gerardine Meaney has contended, “the image of woman as Ireland, Ireland as woman, remains powerful and pervasive in the new Irish cinema” (1998: 250. The cinematic convention of representing Ireland through female characters becomes particularly relevant in two recent Irish historical films: Michael Collins (1996, directed and written by Irish Neil Jordan, and The Wind that Shakes the Barley (2006, written by Scottish Paul Laverty and directed by English Ken Loach. In their dealing with themes such as military occupation, colonisation and the heated debate about the Treaty, both films maintain the nationalist rhetoric that represents Ireland as a woman/mother in a direct manner. Over the course of this essay, I shall try to chart the implications of both films’ representations of women, with a view to demonstrating how, even at present, the trope of Mother Ireland continues to be deep in the national unconscious.

  3. Evolution of generic competitive strategies and the importance of Michael E. Porter La evolución de las estrategias genéricas de competición y la influencia de Michael E. Porter A evolução das estratégias genéricas de competição e a influência de Michael E. Porter

    OpenAIRE

    Wilson Weber; Edison Fernandes Polo

    2010-01-01

    Generic competitive strategies are considered almost as archetypes in Business Administration, sometimes leading to over simplification of their concepts as well as underestimation of their importance. Since publication in 1980, as part of Michael E. Porter's book Competitive Strategy, the generic strategies of Differentiation, Leadership in Total Cost and Focus have been used in whole or in part, in various approaches, accelerating dissemination of Porter's work and the subject itself. As a ...

  4. Asymmetric Michael addition reactions of 3-substituted benzofuran-2(3H)-ones to nitroolefins catalyzed by a bifunctional tertiary-amine thiourea.

    Science.gov (United States)

    Li, Xin; Xue, Xiao-Song; Liu, Cong; Wang, Bin; Tan, Bo-Xuan; Jin, Jia-Lu; Zhang, Yue-Yan; Dong, Nan; Cheng, Jin-Pei

    2012-01-14

    The current work reports an organocatalytic strategy for the asymmetric catalysis of chiral benzofuran-2(3H)-ones bearing 3-position all-carbon quaternary stereocenters. Accordingly, highly enantioselective Michael addition reactions of 3-substituted benzofuran-2(3H)-ones to nitroolefins have been developed by utilizing a bifunctional tertiary-amine thiourea catalyst. The reactions accommodate a number of nitroolefins and 3-substituted benzofuran-2(3H)-ones to give the desired chiral benzofuran-2(3H)-one products with moderate to excellent yields (up to 98%) and moderate to very good selectivities (up to 19 : 1 dr and up to 91% ee). Theoretical calculations using the DFT method on the origin of the stereoselectivity were conducted. The effect of the nitroolefin substituent position on the stereoselectivity of the Michael addition reaction was also theoretically rationalized.

  5. Beyond the center: Sciences in Central and Eastern Europe and their histories. An interview with professor Michael Jordan conducted by Jan Surman

    Directory of Open Access Journals (Sweden)

    Michael Gordin

    2016-11-01

    Full Text Available What is special about sciences in Central and Eastern Europe? What are the obstacles for writing histories of science done beyond metropoles? Is this science different than the science in the centers and what makes it so? How imperial are sciences made by representatives of dominant nations compared to non-dominant nations? These are some of the questions touched upon in the interview with Michael Gordin, a leading historian of science from Princeton University.

  6. Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy.

    Science.gov (United States)

    Zang, Qin; Javed, Salim; Hill, David; Ullah, Farman; Bi, Danse; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Santini, Conrad; Organ, Michael G; Hanson, Paul R

    2012-08-13

    The construction of a 96-member library of triazolated 1,2,5-thiadiazepane 1,1-dioxides was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 94 out of 96 possible products. The key step, a one-pot, sequential elimination, double-aza-Michael reaction, and [3 + 2] Huisgen cycloaddition pathway has been automated and utilized in the production of two sets of triazolated sultam products.

  7. One-pot sequential organocatalytic Michael-Tishchenko-lactonization reactions. Synthesis of enantioenriched 4,5,6-trisubstituted δ-lactones.

    Science.gov (United States)

    Guevara-Pulido, James O; Andrés, José M; Pedrosa, Rafael

    2014-09-19

    Enantioenriched trisubstituted lactones were obtained in good yields and moderate to very good enantioselectivities in one-pot process, which implies a sequential organocatalyzed Michael addition of ketones to enals, followed by catalytic intramolecular diastereoselective Tishchenko reaction and lactonization. The final lactones were obtained as single diastereoisomers, demonstrating that the mixture of the anti and syn diastereomers epimerized to the syn hydroxy ester during the oxido-reduction step.

  8. Evaluation Strategy Michael Porter's five forces model of the competitive environment on the dairy industry (Case Study: Amoll Haraz Dvshh dairy company)

    OpenAIRE

    Mohammad Bolorian Tehrani; Faezeh Rahmani

    2016-01-01

    State of competition in an industry depends on five basic forces. Porter's five forces model including bargaining power of customers, bargaining power of suppliers, threat of newcomers to the industry, threat of substitute products is the intensity of rivalry between competitors. Joint strength of these forces determines the ultimate benefit of potentially any industry. The purpose of this study was to evaluate the competitive environment of the dairy industry based on Michael Por...

  9. Enantioselective organocatalyzed Oxa-Michael-Aldol cascade reactions: Construction of chiral 4H-chromenes with a trifluoromethylated tetrasubstituted carbon stereocenter

    KAUST Repository

    Zhang, Jing

    2015-03-13

    The first organocatalytic asymmetric synthesis of 4H-chromenes bearing a trifluoromethylated tetrasubstituted carbon center is presented. Chiral secondary amines promote the oxa-Michael-aldol cascade reaction between alkynals and 2-trifluoroacetylphenols via iminium-allenamine activation to produce pharmaceutically important heterocycles with excellent enantioselectivities. The proposed reaction can be scaled-up easily with maintenance of the excellent enantioselectivity. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Stereoselective amine-thiourea-catalysed sulfa-Michael/nitroaldol cascade approach to 3,4,5-substituted tetrahydrothiophenes bearing a quaternary stereocenter

    Directory of Open Access Journals (Sweden)

    Sara Meninno

    2016-04-01

    Full Text Available An investigation on the stereoselective cascade sulfa-Michael/aldol reaction of nitroalkenes and commercially available 1,4-dithiane-2,5-diol to 3,4,5-substituted tetrahydrothiophenes, bearing a quaternary stereocenter, is presented. A secondary amine thiourea derived from (R,R-1,2-diphenylethylamine was found to be the most effective catalyst when using trans-β-methyl-β-nitrostyrenes affording the heterocyclic products in good yields and moderate stereoselectivities.

  11. A small stone column of the altar screen from the treasures of St Archangel Michael's monastery in Prevlaka

    Directory of Open Access Journals (Sweden)

    Crnčević Dejan

    2013-01-01

    Full Text Available Amongst exhibited fragments of carved stone decorations in the monastery of St Archangel Michael in Prevlaka, Boka Kotorska, situated on the ground floor of the monastery's accommodation quarters, there is a segment of stone liturgical furnishings which is, among other things, distinguished by its monumental dimensions, the high level of its craftsmanship, and the important artistic value of its carved decorations. This small stone column was found by chance as a surface-level find on the neighbouring island of St Gavrilo. This stone column is made from a monolithic piece of high- quality, light-grey marble. It is 96 cm in height, 20 cm wide at the front, 18.5 cm wide at the side, and 13cm wide at the rear. These dimensions indicate that the fragment has the form of an elongated hexahedron, with sides of unequal width. Only the front of this stone fragment is marked with relief decorations, comprising a regularly shaped two-part curled sprouting vine. Moving with its undulating rhythm, its arc defines a space in which is located the central motif of the decoration. This comprises the motif of a bud in the form of stylised crinoline flower, composed of two lateral leaves with a pronounced bulge in the middle. These tightly bent lateral leaves with sharp ends, together with the root of the formed shoot, leave an empty space filled with an offshoot in the form of a regularly formed volute. The left lateral side of the stone column is marked by a long but relatively shallow channel, created around its axis, with a width of 7.5 cm. Its rear side is divided by its own height into two vertical fields, of almost the same width - 6 and 7 cm respectively - one slightly elevated compared to the other. The right lateral side of the column is slanted and only lightly sculptured. On the upper surface of the pillar, a relatively shallow circular hole with a small span is visible, intended as a connection point for other segments that would have been placed on

  12. Characterization of the crosslinking kinetics of multi-arm poly(ethylene glycol) hydrogels formed via Michael-type addition.

    Science.gov (United States)

    Kim, Jiwon; Kong, Yen P; Niedzielski, Steven M; Singh, Rahul K; Putnam, Andrew J; Shikanov, Ariella

    2016-02-21

    Tunable properties of multi-arm poly(ethylene glycol) (PEG) hydrogel, crosslinked by Michael-type addition, support diverse applications in tissue engineering. Bioactive modification of PEG is achieved by incorporating integrin binding sequences, like RGD, and crosslinking with tri-functional protease sensitive crosslinking peptide (GCYKNRGCYKNRCG), which compete for the same reactive groups in PEG. This competition leads to a narrow range of conditions that support sufficient crosslinking density to provide structural control. Kinetics of hydrogel formation plays an important role in defining the conditions to form hydrogels with desired mechanical and biological properties, which have not been fully characterized. In this study, we explored how increasing PEG functionality from 4 to 8-arms and the concentration of biological moieties, ranging from 0.5 mM to 3.75 mM, affected the kinetics of hydrogel formation, storage modulus, and swelling after the hydrogels were allowed to form for 15 or 60 minutes. Next, human bone marrow stromal cells were encapsulated and cultured in these modified hydrogels to investigate the combined effect of mechano-biological properties on phenotypes of encapsulated cells. While the molar concentration of the reactive functional groups (-vinyl sulfone) was identical in the conditions comparing 4 and 8-arm PEG, the 8-arm PEG formed faster, allowed a greater degree of modification, and was superior in three-dimensional culture. The degrees of swelling and storage modulus of 8-arm PEG were less affected by the modification compared to 4-arm PEG. These findings suggest that 8-arm PEG allows a more precise control of mechanical properties that could lead to a larger spectrum of tissue engineering applications.

  13. Ionic liquids made with dimethyl carbonate: solvents as well as boosted basic catalysts for the michael reaction.

    Science.gov (United States)

    Fabris, Massimo; Lucchini, Vittorio; Noè, Marco; Perosa, Alvise; Selva, Maurizio

    2009-11-16

    This article describes 1) a methodology for the green synthesis of a class of methylammonium and methylphosphonium ionic liquids (ILs), 2) how to tune their acid-base properties by anion exchange, 3) complete neat-phase NMR spectroscopic characterisation of these materials and 4) their application as active organocatalysts for base-promoted carbon-carbon bond-forming reactions. Methylation of tertiary amines or phosphines with dimethyl carbonate leads to the formation of the halogen-free methyl-onium methyl carbonate salts, and these can be easily anion-exchanged to yield a range of derivatives with different melting points, solubility, acid-base properties, stability and viscosity. Treatment with water, in particular, yields bicarbonate-exchanged liquid onium salts. These proved strongly basic, enough to efficiently catalyse the Michael reaction; experiments suggest that in these systems the bicarbonate basicity is boosted by two orders of magnitude with respect to inorganic bicarbonate salts. These basic ionic liquids used in catalytic amounts are better even than traditional strong organic bases. The present work also introduces neat NMR spectroscopy of the ionic liquids as a probe for solute-solvent interactions as well as a tool for characterisation. Our studies show that high catalytic efficacy of functional ionic liquids can be achieved by integrating their green synthesis, along with a fine-tuning of their structure. Demonstrating that ionic liquid solvents can be made by a truly green procedure, and that their properties and reactivity can be tailored to the point of bridging the gap between their use as solvents and as catalysts.

  14. Jane Eyre de Michael Berkeley et de David Malouf : La transposition opératique d’un grand classique de la littérature anglaise Jane Eyre by Michael Berkeley and David Malouf: The Operatic Rewriting of a Great Classic English Novel

    Directory of Open Access Journals (Sweden)

    Jean-Philippe Héberlé

    2009-10-01

    Full Text Available This article discusses Michael Berkeley’s opera Jane Eyre. Premiered on June 30, 2000 by Music Theatre Wales at the Cheltenham International Festival of Music, this opera is based on the novel by Charlotte Brontë and the libretto is written by the Australian poet, novelist, playwright and librettist, David Malouf. It was risky and daring to try to adapt this famous and long novel for the stage. We will particularly focus on the similarities and differences between the novel and the opera as well as on the strategies used both by David Malouf and Michael Berkeley to adapt it. Through the analysis of the similarities we will see how Michael Berkeley set to music some of the great themes and elements of the novel: passion, a sense of entrapment, the “Gothic” atmosphere. On the other hand, the analysis of the discrepancies between the novel and the opera as they appear in both the libretto and the music will lead us to a modern apprehension of the characterization of madness as well as of the metafictional dimension of the rewriting of Jane Eyre by David Malouf and Michael Berkeley.  

  15. Tiheduse kurvid / Michael Sorkin

    Index Scriptorium Estoniae

    Sorkin, Michael

    2007-01-01

    Autor toob välja linnade kasvu mõju maa ökoloogiale. Tema sõnul on demokraatliku linna jaoks kriitiline tihedus linlike vormide ning käitumisviiside tihke kogum ning just tiheduses on vastus jätkusuutlikuks edasi elamiseks meie planeedil

  16. Michael's Inside Scoop: Genetics

    Science.gov (United States)

    ... Washing Experiment John Snow, the First Epidemiologist Microbe Multiplication Magic Scientific Poster Session Poisoned Picnic The Energy ... Help: How do I view different file formats (PDF, DOC, PPT, MPEG) on this site? Adobe PDF ...

  17. A evolução das estratégias genéricas de competição e a influência de Michael E. Porter

    National Research Council Canada - National Science Library

    Wilson Weber; Edison Fernandes Polo

    2010-01-01

    .... Since publication in 1980, as part of Michael E. Porter's book Competitive Strategy, the generic strategies of Differentiation, Leadership in Total Cost and Focus have been used in whole or in part, in various approaches, accelerating dissemination...

  18. Tim Burton lavastab Batmani muusikali. Placido Domingo palkas "Star Warsi" võluri. MTV muusikaauhindade show'l narriti Michael Jacksonit. Hendrixi põlenud kitarr läheb müüki

    Index Scriptorium Estoniae

    2002-01-01

    Jim Steinman kirjutab muusikat Tim Burtoni 2005. aastal lavale tulevale Batmani muusikalile. Los Angelese ooperimaja juht Domingo palkas George Lucase Wagneri ooperi "Nibelungide sõrmus" eriefektide ettevalmistamiseks. Britney Spears nimetas Michael Jacksonit Millenniumi artistiks.

  19. A clinical examination of the efficacy of preparation of Dr Michaels® (also branded as Soratinex®) products in the treatment of psoriasis.

    Science.gov (United States)

    Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Wollina, U; Tirant, M; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

    2016-01-01

    Psoriasis is a chronic inflammatory disease with negative impacts both physically and psychologically. It is a common disorder affecting 2-3% of the total world population, in some cases causing changes to the nail and joints as well as skin lesions. The cutaneous manifestations of psoriasis can vary in morphology and severity and therapy should be tailored accordingly. The aim of the study was to investigate the efficacy of Dr Michaels® (Soratinex®) product line in the treatment of psoriatic patients with different age and disease severity. A total number of 270 patients with verified psoriasis, aged 9-60 years old participated in the studies, including 128 children: 23 girls and 105 boys, (all of them selected from the Department of Dermato-allergology of the Russian Pediatric Hospital Clinic, Moscow, and of the 4th Department of Dermatology of the 52nd Moscow City Hospital Clinic). The patients were separated into 3 groups according to the severity of the disease (based on the PASI-index). All the patients have been treated with Dr Michaels® (Soratinex®) products twice daily, as three different forms were available for application: a cleansing gel, an ointment and a conditioner. The severity of the disease and the efficacy of the treatment have been defined with the evaluation of the PASI index of each patient. The obtained results were recorded in a graphic form showing the changes of the PASI-index on days 3, 7, 14, and 21 counted from the start of the trial. Clinical remission was achieved in 147 patients, a significant improvement in 73, partial improvement in 32, while no effect was seen in 12 patients and deterioration in 6. This open trial demonstrated the clinical efficacy of topical application of Dr Michaels® (Soratinex®) preparation. We observed clinical remissions of psoriasis in adults and in children.

  20. LOS DESAFÍOS DEL DISCURSO DE LA ESTRATEGIA EN LAS ORGANIZACIONES: UNA MIRADA SOBRE LA POSICIÓN DE LA ESTRATEGIA COMPETITIVA DE MICHAEL PORTER

    Directory of Open Access Journals (Sweden)

    Neyda Ibáñez

    2010-04-01

    Full Text Available El propósito se centró en interpretar los desafíos del discurso de la estrategia en las organizaciones, tomando como principal exponente a la Estrategia competitiva de Michael Porter. Para ello, se abordó desde el paradigma interpretativo, con un enfoque cualitativo, usando el método hermenéutico en un contexto teórico enunciativo, documental. Se concluye que los desafíos del discurso de la estrategia en las organizaciones, dependerán de la creatividad, productividad y la capacidad de poder crear conocimiento, ideas y manejar la información.

  1. Nano-organocatalyst: magnetically retrievable ferrite-anchored glutathione for microwave-assisted Paal–Knorr reaction, aza-Michael addition, and pyrazole synthesis

    KAUST Repository

    Polshettiwar, Vivek

    2010-01-01

    Postsynthetic Surface modification of magnetic nanoparticles by glutathione imparts desirable chemical functionality and enables the generation of catalytic sites on the surfaces of ensuing organocatalysts. In this article, we discuss the developments, unique activity, and high selectivity of nano-organocatalysts for microwave-assisted Paal-Knorr reaction, aza-Michael addition, and pyrazole synthesis. Their insoluble character Coupled with paramagnetic nature enables easy separation of these nano-catalysts from the reaction mixture using external magnet, which eliminates the requirement of catalyst filtration. Published by Elsevier Ltd.

  2. An unusual Michael-induced skeletal rearrangement of a bicyclo[3.3.1]nonane framework of phloroglucinols to a novel bioactive bicyclo[3.3.0]octane.

    Science.gov (United States)

    Vidali, Veroniki P; Mitsopoulou, Kornilia P; Dakanali, Marianna; Demadis, Konstantinos D; Odysseos, Andreani D; Christou, Yiota A; Couladouros, Elias A

    2013-11-01

    A novel skeletal rearrangement of bicyclo[3.3.1]nonane-2,4,9-trione (16) to an unprecedented highly functionalized bicyclo[3.3.0]octane system (17), induced by an intramolecular Michael addition, is presented. This novel framework was found to be similarly active to hyperforin (1), against PC-3 cell lines. A mechanistic study was examined in detail, proposing a number of cascade transformations. Also, reactivity of the Δ(7,10)-double bond was examined under several conditions to explain the above results.

  3. An efficient and scalable one-pot double Michael addition-Dieckmann condensation for the synthesis of 4,4-disubstituted cyclohexane beta-keto esters.

    Science.gov (United States)

    DeGraffenreid, Michael R; Bennett, Sarah; Caille, Sebastien; Gonzalez-Lopez de Turiso, Felix; Hungate, Randall W; Julian, Lisa D; Kaizerman, Jacob A; McMinn, Dustin L; Rew, Yosup; Sun, Daqing; Yan, Xuelei; Powers, Jay P

    2007-09-14

    A simple, scalable, and efficient one-pot methodology for the synthesis of 4,4-disubstituted cyclohexane beta-keto esters from benzylic nitriles or esters and methyl acrylate promoted by potassium tert-butoxide is described. The process relies on a tandem double Michael addition-Dieckmann condensation reaction, which results in the formation of three discrete carbon-carbon bonds in a single pot, including a quaternary center. The method allows for the convenient and rapid synthesis of a variety of 4-aryl-4-cyano-2-carbomethoxycyclohexanone and 4-aryl-2,4-biscarbomethoxycyclohexanone building blocks for use in natural products synthesis and medicinal chemistry.

  4. Crystallisation and preliminary X-ray diffraction analysis of the protease from Southampton norovirus complexed with a Michael-acceptor inhibitor

    Energy Technology Data Exchange (ETDEWEB)

    Coates, Leighton [ORNL; Cooper, Jon [University of Southampton, England; Hussey, Robert [University of Southampton, England

    2008-01-01

    Noroviruses are the predominant cause of human epidemic nonbacterial gastroenteritis. Viral replication requires a cysteine protease that cleaves a 200 kDa viral polyprotein into its constituent functional parts. Here, the crystallization of the recombinant protease from the Southampton norovirus is described. While the native crystals were found to diffract only to medium resolution (2.9 {angstrom}), cocrystals of an inhibitor complex diffracted X-rays to 1.7 {angstrom} resolution. The polypeptide inhibitor (Ac-EFQLQ-propenyl ethyl ester) possesses an amino-acid sequence designed to match the substrate specificity of the enzyme, but was synthesized with a reactive Michael acceptor group at the C-terminal end.

  5. Organocatalytic cascade aza-Michael/hemiacetal reaction between disubstituted hydrazines and α,β-unsaturated aldehydes: Highly diastereo- and enantioselective synthesis of pyrazolidine derivatives

    Directory of Open Access Journals (Sweden)

    Zhi-Cong Geng

    2012-10-01

    Full Text Available The catalytic synthesis of nitrogen-containing heterocycles is of great importance to medicinal and synthetic chemists, and also a challenge for modern chemical methodology. In this paper, we report the synthesis of pyrazolidine derivatives through a domino aza-Michael/hemiacetal sequence with chiral or achiral secondary amines as organocatalysts. Thus, a series of achiral pyrazolidine derivatives were obtained with good yields (up to 90% and high diastereoselectivities (>20:1 with pyrrolidine as an organocatalyst, and enantioenriched pyrazolidines are also achieved with good results (up to 86% yield, >10/1 regioselectivity, >20:1 dr, 99% ee in the presence of (S-diphenylprolinol trimethylsilyl ether catalyst.

  6. Analysis of Media Stereotypes of the Russian Image in Media Studies in the Student Audience (example: the screen versions of Jules Verne's Novel “Michael Strogoff”

    Directory of Open Access Journals (Sweden)

    Alexander Fedorov

    2014-09-01

    Full Text Available As a result of the analysis students come to the conclusion that the screen adaptations of Jules Verne's novel ''Michael Strogoff'' create, though an oversimplified and adapted to western stereotypes of perception, but a positive image of Russia – as a stronghold of European values at the Asian frontiers, a country with a severe climate, boundless Siberian spacious areas, manly and patriotic warriors, a wise monarchy. At the same time, both Jules Verne's novel and its screen adaptations contain clear-cut western pragmatism – the confidence that if a man has a proper will he can rule his destiny.

  7. Towards a Theory of Constrained Relativism: Comparing and Combining the Work of Pierre Bourdieu, Mary Douglas and Michael Thompson, and Alan Fiske

    OpenAIRE

    Marco Verweij

    2007-01-01

    In this article, I seek to compare Pierre Bourdieu's theory of practice, the cultural theory developed by Mary Douglas and Michael Thompson, and the relational models theory pioneered by Alan Fiske, and attempt to sketch how these theories could possibly be combined. I argue that the three theories are among the most interesting conceptual enterprises in the social sciences of the last few decades, as they all represent –quite similar– syntheses of long-standing social-science dualisms, s...

  8. The economic role of the Emergency Department in the health care continuum: applying Michael Porter's five forces model to Emergency Medicine.

    Science.gov (United States)

    Pines, Jesse M

    2006-05-01

    Emergency Medicine plays a vital role in the health care continuum in the United States. Michael Porters' five forces model of industry analysis provides an insight into the economics of emergency care by showing how the forces of supplier power, buyer power, threat of substitution, barriers to entry, and internal rivalry affect Emergency Medicine. Illustrating these relationships provides a view into the complexities of the emergency care industry and offers opportunities for Emergency Departments, groups of physicians, and the individual emergency physician to maximize the relationship with other market players.

  9. Resenha: löwy, michael. Ecologia e Socialismo. São paulo: Cortez, 2005. 94p.

    Directory of Open Access Journals (Sweden)

    Flávio Roberto Chaddad

    2013-12-01

    Full Text Available Hoje o mundo vive uma crise ambiental. Ela suscita buscas a fim de se encontrar respostas que tragam horizontes para se pensar o mundo. Nessa busca é que se situa a análise de Michael Löwy sobre o pensamento ecológico no marxismo. Verifica-se, no primeiro capítulo – Progresso destrutivo: Marx, Engels e a Ecologia –, que a ecologia não é tema central nessas obras. Podemos inferir que este fato é decorrente da própria época em que viviam os autores, quando a natureza era vista como um bem ilimitado. Porém, algumas passagens referentes à natureza e de como ela deva ser conduzida pelo ser humano podem ser notadas. Assim, nos manuscritos escritos em 1844, Marx faz referência a natureza como se fosse o corpo orgânico do homem; em um outro texto, sobre o papel do trabalho na transformação do macaco em homem, de 1876, há uma crítica pela forma predatória que o homem utiliza a natureza, considerando que as ações que praticamos contra a natureza se voltam contra nós; no livro III do O Capital, vemos esboçar uma verdadeira problemática ecológica. O que se encontra nesse texto é um tipo de teoria da ruptura do metabolismo entre as sociedades humanas e a natureza, como resultado do produtivismo capitalista; no livro I de O Capital há uma crítica à destruição das florestas e à perda da capacidade produtiva dos solos; na obra de Engels, A Dialética da Natureza, ele cita a desertificação em solo cubano provocado pelos grandes produtores de café; o problema da poluição do meio ambiente não está ausente, mas é abordado sob o ângulo da insalubridade dos bairros operários nas grandes cidades inglesas, nas páginas da A condição da classe operária inglesa de 1844. A partir dessas passagens, como podemos analisar a ecologia na obra de Marx? Podemos dizer que elas parecem considerar que a conservação da natureza está ligada à superação do produtivismo capitalista, como uma tarefa fundamental do socialismo, e isto

  10. A multi-centred open trial of “Dr Michaels®” (also branded as Soratinex®) topical product family in psoriasis.

    Science.gov (United States)

    Wollina, U; Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Tirant, M; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

    2016-01-01

    Psoriasis is a chronic, recurring skin disease affecting 2-4% of the population. Genetic predisposition and precipitating factors play a role in its etiology. The disease can occur in any age or gender group. The most frequently affected areas of the body include scalp, extensor surfaces of the extremities, skin folds and nails. While a number of therapies exist for the treatment of psoriasis with a total resolution of the skin, achieving remission in a high percentage of sufferers, a treatment that results in the maintenance of remission and is free of side effects is still a desirable goal. The aim of the study was to investigate the efficacy and tolerability of Dr Michaels® (Soratinex®) topical product family in psoriasis, in terms of decreasing parakeratosis, inflammation, infiltration and involved area. Seven-hundred-and-twenty-two subjects, mean age 42.3 years (range: 18-68 years) with mild to moderately severe psoriasis, with no other current anti-psoriatic therapy, consisting of 382 males and 340 females, above 18 years of age were included and the observations were subjected to statistical analysis. Triphasic application of Dr Michaels® (Soratinex®) products was employed for 8 weeks, using Cleansing Gel, Scalp and Body Ointment and Skin Conditioner. The treatment proved to be ineffective for 22 patients (3.1%) out of 722. 84 patients (11.6%) had moderate improvement with 26-50% of cleared skin lesions; 102 patients (14.1%) had good improvement with 51-75% of cleared skin lesions; 484 patients (67.0%) experienced outstanding improvement with 76-100% of the cleared skin lesions, with 52% of them achieving total resolution. Twelve patients worsened and discontinued treatment; 18 patients discontinued because of non-compliance; 33 patients developed folliculitis as a side effect. Based on the results of this study, the Dr Michaels® (Soratinex®) product family can be successfully applied in mild to moderately severe psoriasis when considering the

  11. Phospha-Michael addition reaction of maleimides employing N-heterocyclic phosphine-thiourea as a phosphonylation reagent: synthesis of 1-aryl-2,5-dioxopyrrolidine-3-yl-phosphonate derivatives.

    Science.gov (United States)

    Molleti, Nagaraju; Bjornberg, Chad; Kang, Jun Yong

    2016-12-07

    N-Heterocyclic phosphine (NHP)-thiourea as a novel phosphonylation reagent has been successfully applied for the phospha-Michael reaction of maleimides under catalyst and additive free reaction conditions. This methodology enables desymmetrization of a variety of maleimide derivatives to provide 1-aryl-2,5-dioxopyrrolidine-3-yl-phosphonates in up to 92% yield. Synthetic manipulation of this Michael adduct afforded an ethylphosphonate and a phosphino lactam. Furthermore, a scale-up experiment for its practical usage as a versatile precursor in organic synthesis was readily demonstrated.

  12. Concise synthesis of anti-HIV-1 active (+)-inophyllum B and (+)-calanolide A by application of (-)-quinine-catalyzed intramolecular oxo-Michael addition.

    Science.gov (United States)

    Sekino, Etsuko; Kumamoto, Takuya; Tanaka, Tomohiro; Ikeda, Tomoko; Ishikawa, Tsutomu

    2004-04-16

    (-)-Quinine-catalyzed intramolecular oxo-Michael addition (IMA) of 7-hydroxy-5-methoxy-8-tigloylcoumarins was developed for the enantioselective construction of 2,3-dimethyl-4-chromanone systems in the context of the asymmetric synthesis of anti-HIV-1 active Calophyllum coumarins. Combination of the IMA and MgI(2)-assisted demethylation of the 5-methoxy group along with isomerization of the formed chromanone systems as key steps successfully led to the concise synthesis of (+)-inophyllum B and (+)-calanolide A, possible candidates for AIDS drugs. Further examination of the asymmetric IMA with cinchona alkaloids lacking a methoxy group on the quinoline skeleton suggested the influence of the methoxy substituent on stereoselectivity at the stereogenic centers of the chromanone systems.

  13. Review of QMaSC: A Handbook for Directors of Quantitative and Mathematics Support Centers edited by Grace Coulombe, Mary B. O’Neill, and Michael Schuckers (2016

    Directory of Open Access Journals (Sweden)

    Vera Frith

    2017-01-01

    Full Text Available Grace Coulombe, Mary B. O’Neill, and Michael Schuckers (Eds. QMaSC: A Handbook for Directors of Quantitative and Mathematics Support Centers. (Tampa FL: USF Libraries – Tampa Library, 2016. http://scholarcommons.usf.edu/qmasc_handbook/ The over thirty different authors of this handbook, all of whom are experienced in supporting learning in mathematics and quantitative disciplines, provide a useful perspective on the practical issues that affect the running of a learning support centre, as well as the problems of working within a complex institution of higher education. The handbook contains information on leadership and management, how to maintain community interactions, managing staffing (including hiring and training, and sections on assessment and issues related to starting a new centre. It concludes with ten case studies in which various support centres in different types of institutions and with different missions are described in detail.

  14. Dale Maharidge and Michael Williamson’s ‘Homeland’: de-constructing the rhetoric of consensus in the aftermath of September 11th attacks

    Directory of Open Access Journals (Sweden)

    Cinzia Schiavini

    2011-09-01

    Full Text Available Focusing on Dale Maharidge and Michael Williamson’s reportage Homeland (2004, this essay explores the de-construction of the discursive and cultural strategies of the “state of exception” used to depict 9/11 events and the dialectics between domestic and international politics and economies. The analysis focuses in particular on four elements: the concept of “Ground Zero” and “Homeland” and their use as lexical and symbolic catalysts of nationalism; the forms and the erasure of dissent; the commodification of 9/11 and the Iraqi war; and the relation between the national rhetoric and the transnational economy in the last two decades.

  15. Michael-type addition of illudin S, a toxic substance from Lampteromyces japonicus, with cysteine and cysteine-containing peptides in vitro.

    Science.gov (United States)

    Tanaka, K; Inoue, T; Tezuka, Y; Kikuchi, T

    1996-02-01

    Reactions of illudin S with cysteine derivatives (cysteine methyl ester, glutathione and a peptide, Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg) were investigated. In the reaction with cysteine methyl ester, four products (P1, P2, P3, P4) were obtained and their structures were determined, on the basis of MS and NMR data, to be adducts of the mercapto group of cysteine methyl ester with the alpha,beta-unsaturated carbonyl group of illudin S. In the reactions with glutathione and the peptide, two addition products in each case were identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and NMR analyses. The structures of these adducts also indicated that the alpha,beta-unsaturated carbonyl group in illudin S behaves as a Michael acceptor for the mercapto group in cysteine.

  16. IUTAM Symposium on Innovative Numerical Approaches for Materials and Structures in Multi-Field and Multi-Scale Problems : in Honor of Michael Ortiz's 60th Birthday

    CERN Document Server

    Pandolfi, Anna

    2016-01-01

    This book provides readers with a detailed insight into diverse and exciting recent developments in computational solid mechanics, documenting new perspectives and horizons. The topics addressed cover a wide range of current research, from computational materials modeling, including crystal plasticity, micro-structured materials, and biomaterials, to multi-scale simulations of multi-physics phenomena. Particular emphasis is placed on pioneering discretization methods for the solution of coupled non-linear problems at different length scales. The book, written by leading experts, reflects the remarkable advances that have been made in the field over the past decade and more, largely due to the development of a sound mathematical background and efficient computational strategies. The contents build upon the 2014 IUTAM symposium celebrating the 60th birthday of Professor Michael Ortiz, to whom this book is dedicated. His work has long been recognized as pioneering and is a continuing source of inspiration for ma...

  17. Hvordan gør vi tingene her? – et Michael Eraut-inspireret fokus på sygeplejestuderendes første kliniske undervisningsforløb

    DEFF Research Database (Denmark)

    Jensen, Carsten Juul

    2014-01-01

    socializing into the hierarchy of the clinic, toward the progression from being a novice to becoming an advanced beginner, overcoming overwhelming experiences. A socialization supported by newly educated nurses who can still express their practice, or supported by their private relations. When the new nursing......This paper is part of a longitudinal development project. We try to comprehend the learning experience of nursing students during their first clinical study course, aiming to identify how and what nursing students learn to qualify the support of clinical supervisors and educators. The methology...... of the project is qualitative, inspired by the thoughts of Michael Eraut on workplace learning. Seen from the workplace perspective, learning seems to be oriented toward the situations facing the students, rather than toward fabricated study methods. The learning of nursing students seems to be oriented toward...

  18. Multifunctional Electrochemical Platforms Based on the Michael Addition/Schiff Base Reaction of Polydopamine Modified Reduced Graphene Oxide: Construction and Application.

    Science.gov (United States)

    Huang, Na; Zhang, Si; Yang, Liuqing; Liu, Meiling; Li, Haitao; Zhang, Youyu; Yao, Shouzhuo

    2015-08-19

    In this paper, a new strategy for the construction of multifunctional electrochemical detection platforms based on the Michael addition/Schiff base reaction of polydopamine modified reduced graphene oxide was first proposed. Inspired by the mussel adhesion proteins, 3,4-dihydroxyphenylalanine (DA) was selected as a reducing agent to simultaneously reduce graphene oxide and self-polymerize to obtain the polydopamine-reduced graphene oxide (PDA-rGO). The PDA-rGO was then functionalized with thiols and amines by the reaction of thiol/amino groups with quinine groups of PDA-rGO via the Michael addition/Schiff base reaction. Several typical compounds containing thiol and/or amino groups such as 1-[(4-amino)phenylethynyl] ferrocene (Fc-NH2), cysteine (cys), and glucose oxidase (GOx) were selected as the model molecules to anchor on the surface of PDA-rGO using the strategy for construction of multifunctional electrochemical platforms. The experiments revealed that the composite grafted with ferrocene derivative shows excellent catalysis activity toward many electroactive molecules and could be used for individual or simultaneous detection of dopamine hydrochloride (DA) and uric acid (UA), or hydroquinone (HQ) and catechol (CC), while, after grafting of cysteine on PDA-rGO, simultaneous discrimination detection of Pb(2+) and Cd(2+) was realized on the composite modified electrode. In addition, direct electron transfer of GOx can be observed when GOx-PDA-rGO was immobilized on glassy carbon electrode (GCE). When glucose was added into the system, the modified electrode showed excellent electric current response toward glucose. These results inferred that the proposed multifunctional electrochemical platforms could be simply, conveniently, and effectively regulated through changing the anchored recognition or reaction groups. This study would provide a versatile method to design more detection or biosensing platforms through a chemical reaction strategy in the future.

  19. Optimization of the β-elimination/michael addition chemistry on reversed-phase supports for mass spectrometry analysis of O-linked protein modifications.

    Science.gov (United States)

    Nika, Heinz; Nieves, Edward; Hawke, David H; Angeletti, Ruth Hogue

    2013-09-01

    We previously adapted the β-elimination/Michael addition chemistry to solid-phase derivatization on reversed-phase supports, and demonstrated the utility of this reaction format to prepare phosphoseryl peptides in unfractionated protein digests for mass spectrometric identification and facile phosphorylation-site determination. Here, we have expanded the use of this technique to β-N-acetylglucosamine peptides, modified at serine/threonine, phosphothreonyl peptides, and phosphoseryl/phosphothreonyl peptides, followed in sequence by proline. The consecutive β-elimination with Michael addition was adapted to optimize the solid-phase reaction conditions for throughput and completeness of derivatization. The analyte remained intact during derivatization and was recovered efficiently from the silica-based, reversed-phase support with minimal sample loss. The general use of the solid-phase approach for enzymatic dephosphorylation was demonstrated with phosphoseryl and phosphothreonyl peptides and was used as an orthogonal method to confirm the identity of phosphopeptides in proteolytic mixtures. The solid-phase approach proved highly suitable to prepare substrates from low-level amounts of protein digests for phosphorylation-site determination by chemical-targeted proteolysis. The solid-phase protocol provides for a simple, robust, and efficient tool to prepare samples for phosphopeptide identification in MALDI mass maps of unfractionated protein digests, using standard equipment available in most biological laboratories. The use of a solid-phase analytical platform is expected to be readily expanded to prepare digest from O-glycosylated- and O-sulfonated proteins for mass spectrometry-based structural characterization.

  20. Optimization of the β-Elimination/Michael Addition Chemistry on Reversed-Phase Supports for Mass Spectrometry Analysis of O-Linked Protein Modifications

    Science.gov (United States)

    Nika, Heinz; Nieves, Edward; Hawke, David H.; Angeletti, Ruth Hogue

    2013-01-01

    We previously adapted the β-elimination/Michael addition chemistry to solid-phase derivatization on reversed-phase supports, and demonstrated the utility of this reaction format to prepare phosphoseryl peptides in unfractionated protein digests for mass spectrometric identification and facile phosphorylation-site determination. Here, we have expanded the use of this technique to β-N-acetylglucosamine peptides, modified at serine/threonine, phosphothreonyl peptides, and phosphoseryl/phosphothreonyl peptides, followed in sequence by proline. The consecutive β-elimination with Michael addition was adapted to optimize the solid-phase reaction conditions for throughput and completeness of derivatization. The analyte remained intact during derivatization and was recovered efficiently from the silica-based, reversed-phase support with minimal sample loss. The general use of the solid-phase approach for enzymatic dephosphorylation was demonstrated with phosphoseryl and phosphothreonyl peptides and was used as an orthogonal method to confirm the identity of phosphopeptides in proteolytic mixtures. The solid-phase approach proved highly suitable to prepare substrates from low-level amounts of protein digests for phosphorylation-site determination by chemical-targeted proteolysis. The solid-phase protocol provides for a simple, robust, and efficient tool to prepare samples for phosphopeptide identification in MALDI mass maps of unfractionated protein digests, using standard equipment available in most biological laboratories. The use of a solid-phase analytical platform is expected to be readily expanded to prepare digest from O-glycosylated- and O-sulfonated proteins for mass spectrometry-based structural characterization. PMID:23997661

  1. Examination and comparative study of the Ascension of The Prophet of Islam In The View Of Michael Sells And Anne-mari e Shamil with Inter- Religious Attitude

    Directory of Open Access Journals (Sweden)

    Mahdi Azadi

    2015-09-01

    Full Text Available Michael Sells, American scholar of Quran,about the Ascension (Mi,raj of the prophet (PBUH focuses on three issues: First, the Mi,raj term is not used in the Quran and the ascension of the explanation is not enough. second, Mohammad is no different from the miracle of the Quran is the miracle of God,he is not anything else, Quran states. Third, Ascension of the prophet (PBUH has been in sleep and dream.According to him, the discussion about the layers of the subject is based mainly on the evidence of Quran.In this case, only limited information can be found in the Asra chapter (sooreh of the Quran.In addition, he has tried to make the Ascension event from Jewish traditions and the effects Bvdaysm.actually the orientalist`s goal is to prove the absence of ascension of the prophet(PBUH.  In contrast, Anne-marie Shamil stayes that prophet`s ascension derived from the first verse of Asra sura and believes that two processes(horizontal and verticalfor prophet happened.and unlike Michael,he knows mi,raj from the God miracles.Anne-Marie because her sufficient the Sunni sources is doubt with belief in the physical and spiritual ascension,in some of her votes,such as; visible or not visible in the ascension of God by the prophet.Despite the fundamental criticism that some elements of the theory of two Orientalists arrived,positive points are observed in their ideas.in this article we have tried to express the views of the Orientalists, then to review their ideas considered

  2. "Kommentar zu „Ableitung von Korngrößenverteilungen aus textbasierten petrografischen Bohrgutbeschreibungen“ von Michael Naumann, Anja Waldeck, Wolfgang Poßin, Carsten Schwarz & Joachim Fritz (Z. Dt. Ges. Geowiss., 165/2: 275–286)"

    DEFF Research Database (Denmark)

    Fuchs, Sven

    2015-01-01

    Fuchs, S. (2015): Kommentar zu „Ableitung von Korngrößenverteilungen aus textbasierten petrografischen Bohrgutbeschreibungen“ von Michael Naumann, Anja Waldeck, Wolfgang Poßin, Carsten Schwarz & Joachim Fritz (Z. Dt. Ges. Geowiss., 165/2: 275?286). [Comment on “Deduction of grain size distributions...

  3. An organocatalytic Michael-cyclization cascade of 4-oxa-α,β-unsaturated carboxylic acids with aldehydes: facile synthesis of chiral γ-lactols and trisubstituted γ-lactones.

    Science.gov (United States)

    Lin, Jun-Bing; Xu, Shi-Ming; Xie, Ji-Kang; Li, Hong-Yu; Xu, Peng-Fei

    2015-02-28

    An organocatalytic Michael-cyclization cascade of aldehydes with 4-oxa-α,β-unsaturated carboxylic acids has been developed, giving functionalized γ-lactols with high yields and enantioselectivities. The products could be easily transformed into complex trisubstituted γ-lactones and γ-lactams.

  4. El lugar de la historia en tiempos de globalización: Un análisis a partir de Marc Abélès y Michael Hardt-Antonio Negri The Place of the History in Times of Globalization: An Analysis from Marc Abélès and Michael Hardt-Antonio Negri

    Directory of Open Access Journals (Sweden)

    Tuillang Yuing Alfaro

    2011-07-01

    Full Text Available El siguiente texto intenta abordar la relación existente entre los procesos de globalización-mundialización y ciertas concepciones de historia que le son solidarias. Para lo anterior apela a las reflexiones realizadas por Marc Abélès en Política de la supervivencia y Michael Hardt y Antonio Negri en Imperio. En ambos análisis se puede percibir la importancia que tiene la historia como soporte de los procesos globales que entremezclan lo político, lo económico y lo cultural, procesos que parecen avanzar, según el curso de la historia, y que permiten además dar referencia de sentido a los sujetos en sus procesos identitarios y de individuación.The following text tries to approach the relation between the globalization-mondialisation process and certain conceptions of history witch are solidary with them. For the previous thing, it appeals to the reflections realized by Marc Abélès in Politics of the survival and Michael Hardt and Antonio Negri in Empire. In both analyses it is possible to perceive the importance that takes the history as a support of the global processes that intermingle the politics, the economy and culture, processes that seem to advance according to the course that history has, and they allow to give in addition reference of sense to the subjects in his processes of identity and of individuation.

  5. Investigation of the efficacy and tolerability of Dr Michaels® (also branded as Eczitinex® and Itchinex Eczitinex®) topical products in the treatment of atopic dermatitis in children.

    Science.gov (United States)

    França, K; Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Wollina, U; Tirant, M; Bayer, P; Coburn, M; Anderson, P; Donnelly, B; Kennedy, T; Gaibor, J; Arora, M; Clews, L; Novotny, F; Roccia, M G; Maximov, G K; Lotti, T

    2016-01-01

    Atopic eczema is a chronic relapsing inflammatory skin disorder, characterized clinically by intensely pruritic eczematous skin lesions and a defective epidermal barrier. It affects more than 15% of children and up to 10%of adults, which makes the disease a social health problem still without a challenging treatment. The aim of this study was to evaluate the efficacy and tolerability of Dr Michaels® (Eczitinex®) topical product family in the treatment of atopic dermatitis in children. We studied a group of 30 patients (17 female, 13 male), aged 5 to 13 (mean age: 9), affected by atopic dermatitis since they were newborn. All patients had been unsuccessfully treated with conventional anti-inflammatory therapies and ceased treatment 2 weeks before commencing research. The patients were treated with Dr Michaels® (Eczitinex® and Itchinex®) product family including a moisturising bar, topical ointment and PSC 900 oral herbal formulation. The treatment was evaluated clinically and photographically at 0, 1, 2, 4, 6, 8, 10, 12, and 14 weeks. Twenty-eight patients showed a significant improvement of cutaneous rashes and pruritus on the first week of treatment, with a complete remission at 10-12 weeks. Only two patients, brother and sister respectively, showed a slow response to treatment and reported an increasing itching. Following 14 weeks of treatment with the Dr Michaels® (Eczitinex® and Itchinex®) product family, patients demonstrated complete resolution of their AD. All patients showed a marked improvement in their condition within 3 days of treatment with most of the lesions and symptoms totally resolved within 10 to 12 weeks of treatment with Dr Michaels® (Eczitinex® and Itchinex®) family of products. This clinical report highlights that the Dr Michaels® (Eczitinex® and Itchinex®) product family is a safe and effective treatment option for AD.

  6. A strategy for the generation, characterization and distribution of animal models by The Michael J. Fox Foundation for Parkinson’s Research

    Directory of Open Access Journals (Sweden)

    Marco A. S. Baptista

    2013-11-01

    Full Text Available Progress in Parkinson’s disease (PD research and therapeutic development is hindered by many challenges, including a need for robust preclinical animal models. Limited availability of these tools is due to technical hurdles, patent issues, licensing restrictions and the high costs associated with generating and distributing these animal models. Furthermore, the lack of standardization of phenotypic characterization and use of varying methodologies has made it difficult to compare outcome measures across laboratories. In response, The Michael J. Fox Foundation for Parkinson’s Research (MJFF is directly sponsoring the generation, characterization and distribution of preclinical rodent models, enabling increased access to these crucial tools in order to accelerate PD research. To date, MJFF has initiated and funded the generation of 30 different models, which include transgenic or knockout models of PD-relevant genes such as Park1 (also known as Park4 and SNCA, Park8 (LRRK2, Park7 (DJ-1, Park6 (PINK1, Park2 (Parkin, VPS35, EiF4G1 and GBA. The phenotypic characterization of these animals is performed in a uniform and streamlined manner at independent contract research organizations. Finally, MJFF created a central repository at The Jackson Laboratory (JAX that houses both non-MJFF and MJFF-generated preclinical animal models. Funding from MJFF, which subsidizes the costs involved in transfer, rederivation and colony expansion, has directly resulted in over 2500 rodents being distributed to the PD community for research use.

  7. Application of Just War principles to nuclear war and deterrence in three contemporary theorists: Michael Walzer, Paul Ramsey, and William V. O'Brien

    Energy Technology Data Exchange (ETDEWEB)

    Sichol, M.W.

    1984-01-01

    The purpose of this study is to show that the Just War tradition remains applicable in the nuclear age; three contemporary just war theorists have been selected to show that this is the case: Michael Walzer, political theorist; Paul Ramsey, theologian, and William V. O'Brien, professor of international law. Each is also influenced by his Jewish, Protestant and Roman catholic tradition respectively. The focus is on the principles of proportionality and discrimination, showing how the three theorists define, validate, and apply these principles to the conduct of war as compared to the concepts of the classic Just War theorists and to those expressed in the 1983 US Catholic Bishops' Statement. This Statement reflects the influence of the three secular theorists and also of contemporary moral theory. Just War principles are applied to the uses of nuclear weapons in war-fighting and deterrence and to actual public policy. Just War principles provide policy makers with a moral basis to move beyond national egoism by directing them to be concerned about the needs of the person and about the interdependence among states principles whose validity has often been assumed but whose application has never been so necessary.

  8. Diastereoselective one-pot Wittig olefination-Michael addition and olefin cross metathesis strategy for total synthesis of cytotoxic natural product (+)-varitriol and its higher analogues.

    Science.gov (United States)

    Ghosal, Partha; Sharma, Deepty; Kumar, Brijesh; Meena, Sanjeev; Sinha, Sudhir; Shaw, Arun K

    2011-11-07

    A stereoselective route for the total synthesis of anticancer marine natural product (+)-varitriol (1) is detailed herein. The impressive biological activity and interesting structural features of natural (+)-varitriol fuelled us to undertake the synthesis of some higher analogues (1a-j) of this molecule. The key features of the synthetic strategy include one-pot Wittig olefination followed by a highly diastereoselective oxa-Michael addition to assemble stereochemically pure tetrasubstituted THF moiety of the natural varitriol and olefin cross metathesis to couple the aromatic part with tetrasubstituted THF moiety. The total synthesis of title natural product is efficient with 21.8% overall yield for 9 linear steps from D-ribose and thus facilitates the more scaled-up practical route for the synthesis of 1 and its analogues as well. The synthetic (+)-varitriol (1) and its analogues were screened for their cytotoxicity. The present synthetic approach paves the way for preparation of numerous analogues of the title natural product for drug development.

  9. Michael Cunningham’s The Hours : echoes of Virginia Woolf  The Hours : échos de Virginia Woolf

    Directory of Open Access Journals (Sweden)

    Linda Pillière

    2009-11-01

    Full Text Available Le roman The Hours de Michael Cunningham est une œuvre qui s’inspire directement de Mrs Dalloway et qui s’affiche comme telle. Cependant s’agit-il d’un simple pastiche ou d’une œuvre autonome, une création originale? Nous commencerons par relever les principaux thèmes repris et développés par Cunningham. Nous nous attacherons ensuite à analyser quelques procédés du style woolfien, notamment la syntaxe brisée et la répétition lexicale, pour voir si Cunningham se contente simplement de citer quelques passages de Mrs Dalloway ou si, au contraire, son écriture laisse transparaître ces traits spécifiques du style woolfien. Nous tenterons alors de déterminer si  ces procédés sont simplement pastichés par Cunningham ou si l’auteur américain parvient à créer sa propre voix.

  10. Molecular Characterization of Thiols in Fossil Fuels by Michael Addition Reaction Derivatization and Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.

    Science.gov (United States)

    Wang, Meng; Zhao, Suoqi; Liu, Xuxia; Shi, Quan

    2016-10-04

    Thiols widely occur in sediments and fossil fuels. However, the molecular composition of these compounds is unclear due to the lack of appropriate analytical methods. In this work, a characterization method for thiols in fossil fuels was developed on the basis of Michael addition reaction derivatization followed by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS). Model thiol compound studies showed that thiols were selectively reacted with phenylvinylsulfone and transformed to sulfones with greater than 98% conversions. This method was applied to a coker naphtha, light and heavy gas oils, and crude oils from various geological sources. The results showed that long alkyl chain thiols are readily present in petroleum, which have up to 30 carbon atoms. Large DBE dispersity of thiols indicates that naphthenic and aromatic thiols are also present in the petroleum. This method is capable of detecting thiol compounds in the part per million range by weight. This method allows characterization of thiols in a complex hydrocarbon matrix, which is complementary to the comprehensive analysis of sulfur compounds in fossil fuels.

  11. Precise Probing of Residue Roles by Post-Translational β,γ-C,N Aza-Michael Mutagenesis in Enzyme Active Sites.

    Science.gov (United States)

    Dadová, Jitka; Wu, Kuan-Jung; Isenegger, Patrick G; Errey, James C; Bernardes, Gonçalo J L; Chalker, Justin M; Raich, Lluís; Rovira, Carme; Davis, Benjamin G

    2017-11-22

    Biomimicry valuably allows the understanding of the essential chemical components required to recapitulate biological function, yet direct strategies for evaluating the roles of amino acids in proteins can be limited by access to suitable, subtly-altered unnatural variants. Here we describe a strategy for dissecting the role of histidine residues in enzyme active sites using unprecedented, chemical, post-translational side-chain-β,γ C-N bond formation. Installation of dehydroalanine (as a "tag") allowed the testing of nitrogen conjugate nucleophiles in "aza-Michael"-1,4-additions (to "modify"). This allowed the creation of a regioisomer of His (iso-His, Hisiso) linked instead through its pros-Nπ atom rather than naturally linked via C4, as well as an aza-altered variant aza-Hisiso. The site-selective generation of these unnatural amino acids was successfully applied to probe the contributing roles (e.g., size, H-bonding) of His residues toward activity in the model enzymes subtilisin protease from Bacillus lentus and Mycobacterium tuberculosis pantothenate synthetase.

  12. Stereoselective synthesis of diazaspiro[5.5]undecane derivatives via base promoted [5+1] double Michael addition of N,N-dimethylbarbituric acid to diaryliedene acetones

    Directory of Open Access Journals (Sweden)

    Mohammad Shahidul Islam

    2017-01-01

    Full Text Available The nitrogen containing spiro-heterocycle is one of the privileged synthetic motif that constitutes various naturally occurring molecules and displays a broad range of pharmaceutical and biological activities. A new methodology was developed for the synthesis of 2,4-diazaspiro[5.5]undecane-1,3,5,9-tetraones spiro-heterocyclic derivatives via cascade cyclization of [5+1] double Michael addition reaction of N,N-dimethylbarbituric acid with the derivatives of diaryldivinylketones in the presence of diethylamine at ambient temperature. The developed protocol is highly capable of furnishing diazaspiro[5.5]undecane derivatives 3a–m in excellent yields (up to 98%, from easily accessible symmetric and non-symmetric divinylketones 2a–m, containing aryl and heteroaryl substituents. The diazaspiro-heterocyclic structure was mainly elucidated by NMR and X-ray crystallographic techniques. The single-crystal X-ray studies revealed that, the cyclohexanone unit of spirocycles often prefers a chair conformation rather than twisted conformation. The intermolecular hydrogen bonding and CArH⋯π, π–π stacking interactions driving forces are mainly responsible for the crystal packing.

  13. Michael Faraday en die letterlike lesing van twee ‘boeke’ van God: 'n Gevallestudie oor verhouding tussen geloof en wetenskap1

    Directory of Open Access Journals (Sweden)

    M. Elaine Botha

    1993-03-01

    Full Text Available The cognitive historical approach to the history of science provides a methodological approach which makes it possible to take into account most of the factors which were constitutive in the formation of scientific meaning in scientific concept formation. In this article this approach is linked with a methodology of metaphorical hermeneutics in order to determine the role played by religious factors in the meaning of scientific concepts. Contrary to traditional approaches in which religious factors are primarily seen as confessional in nature, the term religious is utilized here to identify those absolute presuppositions which fulfil a controlling or regulative function in scientific concept formation and theorizing. 'This approach is applied to a case study of the relationship of faith and science in the work of the nineteenth century British physicist, Michael Faraday. This approach provides an analysis of the change in conceptual structure which the concept of force undergoes in a transition from a mechanistic to a dynamistic metaphysical framework. In this analysis attention is also given to the distinction between confessional religious factors, metaphysical frameworks, meta-scientific principles and theories.

  14. CITRA PERUSAHAAN DALAM BERITA KRISIS PERUSAHAAN: Konstruksi Citra Perusahaan Daerah Taman Satwa (PDTS Kebun Binatang Surabaya dalam Teks Berita Kematian Michael di Harian Jawa Pos dan Sindo

    Directory of Open Access Journals (Sweden)

    Theresia Intan Putri Hartiana

    2014-12-01

    Full Text Available Penelitian ini dilakukan untuk melihat bagaimana Harian Jawa Pos dan Sindo membentuk citra Perusahaan Daerah Taman Satwa (PDTS Kebun Binatang Surabaya (KBS dikonstruksikan dalam berita krisis kematian Michael. Metode yang digunakan dalam penelitian ini adalah framing Entman dengan merujuk pada pemberian definisi, penelasan, evaluasi, dan rekomendasi acana untuk melihat penekanan pada kerangka berpikir terhadap peristiwa yang dicanangkan. Citra PDTS KBS dalam Harian Jawa Pos memperlihatkan adanya kondisi Kebun Binatang Surabaya sudah tidak layak bagi satwanya dan kesengajaan keterlibatan orang dalam menjadi penyebab kematian Singa KBS mati tergantung. Citra PDTS KBS oleh Koran Sindo ditampilkan sebagai pihak yang harus bertanggungjawab atas kelalaian dan kecerobohannya dalam memelihara satwa sehingga mengakibatkan terjadi kematian satwa yang tidak wajar. Hal tersebut terlihat dari analisis makrostruktur teks yang memaparkan bahwa kepolisian dilibatkan untuk menyelidiki singa yang mati tergantung akibat kelalaian PDTS KBS dalam pengelolaan satwa. Pemberitaan yang dimunculkan oleh media massa patut menjadi perhatian oleh praktisi Public Relations. Berita yang dikonstruksi negatif secara terus menerus dapat memberikan pengaruh negatif pula di dalam benak pembaca. Beberapa pernyataan negatif yang muncul dalam teks pemberitaan dapat dijadikan sebagai dasar perencanaan bagi humas PDTS KBS dalam penanganan krisis dan perbaikan citra setelah krisis.

  15. Commonalities and Differences Between Max Weber and Michael Foucault on the Theme of “Rationalization of the Body”(“Bedenin Ussallaşması” Teması Üzerinde Max Weber ve Michael Foucault Arasındaki Yakınsamalar ve Farklılıklar

    Directory of Open Access Journals (Sweden)

    Buğra ÖZER

    2010-01-01

    Full Text Available The main objective of this paper is to elucidate the very nature of ‘the rationalization of the body’ in regard to the convergence and divergences as envisioned in the works of Max Weber and Michael Foucault. While both of the thinkers may be deemed to be important critiques of the modernity process, their insights reveal certain commonalities as the came to deal with the rationalization of the body and individuation of the body along with differences that can be traced back to their roots in their critiques about the modernity project. In such respect, the study emphasizes that rationalization of the body has been a complex process and it italicizes that different dynamics came to redefine the body and individuate the individual along with the continuation of the process.

  16. Evolution of generic competitive strategies and the importance of Michael E. Porter La evolución de las estrategias genéricas de competición y la influencia de Michael E. Porter A evolução das estratégias genéricas de competição e a influência de Michael E. Porter

    Directory of Open Access Journals (Sweden)

    Wilson Weber

    2010-03-01

    Full Text Available Generic competitive strategies are considered almost as archetypes in Business Administration, sometimes leading to over simplification of their concepts as well as underestimation of their importance. Since publication in 1980, as part of Michael E. Porter's book Competitive Strategy, the generic strategies of Differentiation, Leadership in Total Cost and Focus have been used in whole or in part, in various approaches, accelerating dissemination of Porter's work and the subject itself. As a contribution to the development of knowledge about generic strategies, extensive research was carried out comparing the best known proposals such as such as the outpacing strategies (GILBERT; STREBEL, 1987, 1989, the value disciplines (TREACY; WIERSEMA, 1995, and the Delta Project (HAX; WILDE, 2001 among others, while adopting Porter's work (1980 as reference. It becomes evident that this work is not only versatile, as confirmed by use in proposals of other authors, but that it remains up to date, influential and can serve as a basis for conceptual advances of more recent complementary proposals and development of unique strategies by organizations.Las estrategias genéricas de competición son tratadas en Administración casi como arquetipos, lo que, a veces, puede llevar a una simplificación exagerada de sus conceptos y a la subvaloración de su relevancia. Desde su publicación en 1980, como parte del libro Compettitive Strategy, de Michael E. Porter, las estrategias genéricas de Diferenciación, Liderazgo en el Costo Total y Foco han sido utilizadas total o parcialmente en varios abordajes, acelerando la diseminación no sólo de ese trabajo de Porter, como del tema. Proponiéndose ofrecer una contribución para el desarrollo del conocimiento sobre estrategias genéricas, adoptamos el trabajo de Porter (1980 como referencia y realizamos una revisión bibliográfica profunda, comparándolo con las propuestas m

  17. Facile and Promising Method for Michael Addition of Indole and Pyrrole to Electron-Deficient trans-β-Nitroolefins Catalyzed by a Hydrogen Bond Donor Catalyst Feist’s Acid and Preliminary Study of Antimicrobial Activity

    Directory of Open Access Journals (Sweden)

    Abdullah M. A. Al Majid

    2014-01-01

    Full Text Available The importance of cooperative hydrogen-bonding effects has been demonstrated using novel 3-methylenecyclopropane-1,2-dicarboxylic acid (Feist’s acid (FA as hydrogen bond donor catalysts for the addition of indole and pyrrole to trans-β-nitrostyrene derivatives. Because of the hydrogen bond donor (HBD ability, Feist’s acid (FA has been introduced as a new class of hydrogen bond donor catalysts for the activation of nitroolefin towards nucleophilic substitution reaction. It has effectively catalyzed the Michael addition of indoles and pyrrole to β-nitroolefins under optimum reaction condition to furnish the corresponding Michael adducts in good to excellent yields (up to 98%. The method is general, atom-economical, convenient, and eco-friendly and could provide excellent yields and regioselectivities. Some newly synthesized compounds were for examined in vitro antimicrobial activity and their preliminary results are reported.

  18. Michael K: Pastiche, Parody or the Inversion of Michael Kohlhaas ...

    African Journals Online (AJOL)

    Attwell 1993; Penner 1989; Horn P. 2000). Nadine Gordimer rejected the reference to Kafka and said that K “probably stands for Kotze or Koekemoer and has no reference, nor need it have, to Kafka” (1984:3). But as far as I can see nobody has ...

  19. Defect-free network formation and swelling behavior in ionic liquid-based electrolytes of tetra-arm polymers synthesized using a Michael addition reaction.

    Science.gov (United States)

    Yoshitake, Mari; Kamiyama, Yuji; Nishi, Kengo; Yoshimoto, Nobuko; Morita, Masayuki; Sakai, Takamasa; Fujii, Kenta

    2017-11-01

    The gelation mechanism of tetra-arm poly(ethylene glycol) (TetraPEG) prepolymers via a Michael addition reaction was investigated from the viewpoint of chemical reaction kinetics. The polymer network was formed by mixing two different TetraPEGs functionalized with maleimide and thiol terminal groups (TetraPEG-MA and TetraPEG-SH) in aqueous solutions, and the gelation rate was strongly dependent on the solution pH. We found that the gelation reaction can be a second-order reaction when the acid-base equilibrium of the terminal SH groups (-SH ⇆ -S(-) + H(+)) was taken into account, resulting in a quantitative estimation of the rate constant (kgel) in the current polymer solution system. Based on the kgel value, the network connectivity (p), which corresponds to efficiency at the linking point, was evaluated to be p > 95% at the end of the reaction; thus, the resulting TetraPEG hydrogels have a homogeneous polymer network without network defects. We used the TetraPEG network as a polymer matrix in a lithium-ion battery gel electrolyte: dried TetraPEG gels were swollen with ionic liquid-based electrolytes containing Li salts to prepare TetraPEG ion gel electrolytes. Swelling behaviors of the TetraPEG network were characterized from the swelling rate and the equilibrium swelling ratio, and we found that these swelling behaviors were significantly affected by the Li-ion component. We concluded that an intermolecular interaction between Li-ions and the polymer (Li-ion coordination with the O atoms within the PEG chains) plays a key role in the fundamental physical properties of the gel electrolyte.

  20. Imperi coloniali da Oriente a Occidente: immagini dell’Altro da Tacito a David Malouf, da Salman Rushdie a Michael Ondaatje

    Directory of Open Access Journals (Sweden)

    Elvira Gòdono

    2011-11-01

    Full Text Available Many centuries before Joseph Conrad’s Heart of Darkness (1902 and Rudyard Kipling’s Kim (1901 were published, the East and West were still divided, as in Tacito’s De Germania, by a limes also visible in David Malouf’s An Imaginary Life (1978, in which the poet Ovid exiled at Tomi, is friends with the savage Child, of animal nature in a human body, similar to the metamorphic migrants of Salman Rushdie’s The Satanic Verses (1988, which hides the magnificent and ancient East of Mahābhārata and Rāmāyana in many Western identities, lost in diabolic European cities. This chaotic antithesis in Michael Ondaatje’s pages lets Sri Lanka’s childish ghosts float amidst stories of peregrination and in search of a Promised Land. In the Skin of a Lion (1987 includes an epigraph from the ancient poem of Gilgamesh, an Eastern echo in a novel profoundly important for many Western studies that often focus on the theory of the canon or on postmodern literature. These categories are discussed with the prospect of broadening cultural and post-colonial studies, in order to merge theory of genres and thematic criticism with anthropology, mythology, and ethnology. Multiple citations expand the original object of research, adding the colonial prophecy present in North American myths, as demonstrated by Margaret Atwood, Margaret Laurence or Lévi-Strauss. Incessantly moving from one space to another, authors give voice to the native cry from multiple perspectives, narrating – like all colonial empires founded on human cruelty– the beast’s nature that has shown its worst aspect.

  1. 'Irish & Roman Catholic Which Upsets All the People Here': Michael McDonnell and British Colonial Justice in Mandatory Palestine, 1927-1936.

    Science.gov (United States)

    Davis, Simon

    2017-10-23

    In 1927 Michael McDonnell, a diasporic Irish Catholic, was appointed Mandatory Palestine's Chief Justice, being directed to institute firm British-style legal-judicial foundations for future self-governance. This entailed common, equal status for Arab and Jewish Palestinians, implicitly de-privileging the Jewish National Home. McDonnell was resisted in this by the British Mandate's Anglo-Jewish, pro-Zionist Attorney General, Norman Bentwich. McDonnell prevailed but only at the cost of being characterized lastingly as a pro-Arab, Catholic anti-Semite. McDonnell's continuing defence of a supreme, independent judiciary antagonized the Palestine Executive of High Commissioner Arthur Wauchope, who tried to co-opt rather than subordinate Zionist interests. Consequent frictions culminated in 1936 with McDonnell adjudicating against supra-legal British repression of Palestine's great Arab rebellion. For this he was dismissed and ostracized, subsequently publishing critiques of British policy in fringe right-wing organs. Yet McDonnell professed explicitly non-racist views, reflecting a liberal-minded, constitutional Irish nationalist equation of Palestine with Ireland, seeing comparable settler-colonial abuses and native distress as remediable only by transcendentally impartial justice. Britain reneging on these principles led McDonnell, like those Irish imperial servants noted in India, to identify with colonial subjects against colonialism. His case is one of empire as a system of domination being challenged from within, although his removal foreshadowed emerging imperial counter-insurgency's tendency not only to repress subject populations but deny civil-progressive alternatives for managing post-colonial transition. © The Author [2017]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  2. Berry, Prof. Sir Michael Victor

    Indian Academy of Sciences (India)

    Address: Professor of Physics, HH Wills Physics Laboratory, University of Bristol, Royal Fort, Tyndall Avenue, Bristol BS8 1TL, U.K.. Contact: Office: (+44-117) 928 8778. Residence: (+44-117) 973 2240. Fax: (+44-117) 925 5624. Email: asymptotico@bristol.ac.uk. http://michaelberryphysics.wordpress.com · YouTube · Twitter ...

  3. The Napoleon Graves / Michael Tarm

    Index Scriptorium Estoniae

    Tarm, Michael

    2002-01-01

    Vilniuse lähedal leiti 1812. a. Isamaasõjas hukkunud prantsuse sõdurite matmispaik. Säilmete antropoloogilised uuringud võimaldavad kindlaks määrata hukkunute vanuse, soo ja tõenäolise surma põhjuse

  4. Michael Polanyi (1891–1976)

    Indian Academy of Sciences (India)

    carried out using a simple apparatus consisting of glass tubes. The rate of the reaction was measured by determining the width of the salt deposited. Polanyi and co-workers found that the measured reaction rates for the alkali-halogen reactions were much larger than what was predicted by the collision theory. This implied ...

  5. Tshelovek s britvoi / Michael Mayer

    Index Scriptorium Estoniae

    Mayer, Michael

    2006-01-01

    Venemaa president Vladimir Putini käitumist võib hinnata mitmeti, kriitikud süüdistavad teda demokraatia lämmatamises ning püüdes taastada nõukogude impeeriumi, kuid nad hindavad tema saavutusi. Hinnangud ja järeldused seoses Ukraina-Vene gaasitüliga, Kremli administratsiooni võim

  6. Michael Polanyi's Philosophy of Science

    Indian Academy of Sciences (India)

    Positivism may be said to be the outcome of the changing contours of modern science that relies solely on observation, experimentation, and measurement. Experiments in modern science are designed solely to elicit 'yes' or 'no' for an answer. The resultant facts can be fitted into clusters, groups, manifolds, and sets.

  7. Michael Foucault og liberalisme kritik

    DEFF Research Database (Denmark)

    Villadsen, Kaspar Feilberg

    2002-01-01

    Den Foucault-inspirerede sociologi har gennem en årrække været domineret af den såkaldte “governmentality litteratur“. Herhjemme har især dens britiske og australske repræsentanter i stigende grad fungeret som inspirationskilder. Artiklen diskuterer nogle problematiske tendenser i denne litteratur...

  8. TRANSFORMING THE LEGACY OF INDIAN RESIDENTIAL SCHOOLS IN CANADA INTO A PUBLIC ISSUE: A CRITICAL ANALYSIS OF MICHAEL BURAWOY’S PUBLIC SOCIOLOGY

    Directory of Open Access Journals (Sweden)

    Petoukhov, Konstantin S.

    2013-01-01

    Full Text Available The Canadian government designed Indian residential school (IRS system to assimilate Indigenous children into European settler society by dispossessing them of their cultures, languages and traditions. By severing the children’s ties to families and communities, and thus integrating them into Euro-Canadian society, the Crown sought to gain control of Indigenous lands (Miller, 2000. In the schools, which were run by church officials, many children died of neglect and diseases and often faced various other injustices perpetrated by staff, including physical, emotional, cultural, and sexual abuse. (Milloy, 1999. Although the last school was closed in 1996, IRS left behind a devastating legacy characterized by sexual and physical abuse in Indigenous communities, substance abuse, loss of Indigenous languages, over-representation of Indigenous people in correctional facilities, and others. Until recently, these were considered to be private issues. However, the growing body of evidence demonstrates that IRS were responsible for the negative impacts and the government and churches were compelled to recognize the damage done. This article explores Michael Burawoy’s (2005 four types of sociology (policy, critical, professional, and public and assesses the relative contributions of each type in the process of transforming “private troubles” of the IRS legacy into “public issues.” The main thesis of the article is that each type of sociology, with varying degrees of success, promotes the recognition of the injustices inflicted by IRS. The article concludes that Burawoy’s sociology possesses its strengths and weaknesses in identifying private troubles as public issues.Le gouvernement canadien a conçu des pensionnats autochtones (PA pour assimiler les enfants indigènes dans la société des colons européens en les dépossédant de leurs cultures, langues et traditions. En rompant les liens de l'enfant avec ses familles et communautés, et

  9. Clinical evaluation of the effectiveness of “Dr Michaels®” (also branded as Soratinex®) products in the topical treatment of patients with plaque psoriasis.

    Science.gov (United States)

    Fioranelli, M; Hercogovấ, J; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Wollina, U; Tirant, M; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

    2016-01-01

    Psoriasis is generally considered as an autoimmune inflammatory cutaneous-systemic disease, with chronic course and high rate of recurrence, while its high risk of comorbidities affect the patients’ quality of life significantly. Despite the good therapeutic response, most of the available options show tendency for poor tolerance and high rate of occurrence of side effects. Therefore, the interest of patients and doctors to investigate the possibility of treating psoriasis with natural substances is not surprising. The aim of this study was to investigate the efficacy and safety of the herbal skin-care product Dr Michaels® (Soratinex®) for the management of chronic plaque psoriasis, within a 6 to 8 week treatment course. Thirty patients of both sexes, aged between 24 and 70 years with mild to moderate psoriasis vulgaris were included in this study. The products of Dr Michaels® (Soratinex®) were applied in sequence: cleansing gel, ointment after 3-4 minutes and tonic care (for the fire-smeared ointment) 2 times per day for restorative care and cleansing gel for psoriasis within scalp 3 times a week. The study lasted six weeks. The severity and extent of the lesions were evaluated by PASI score (Psoriasis Area and Severity Index). Based on the obtained result, the products of “Dr Michaels® (Soratinex®)” have proved to be effective in the treatment of mild and moderate psoriasis vulgaris. In the study group, no improvement was observed in 10% of patients, a slight improvement in 20%, good in 40% and very good in 16.6% of patients.

  10. Organocatalytic Asymmetric Michael/Cyclization Cascade Reactions of 3-Hydroxyoxindoles/3-Aminooxindoles with α,β-Unsaturated Acyl Phosphonates for the Construction of Spirocyclic Oxindole-γ-lactones/lactams.

    Science.gov (United States)

    Chen, Lin; Wu, Zhi-Jun; Zhang, Ming-Liang; Yue, Deng-Feng; Zhang, Xiao-Mei; Xu, Xiao-Ying; Yuan, Wei-Cheng

    2015-12-18

    Enantioselective Michael/cyclization cascade reactions of 3-hydroxyoxindoles/3-aminooxindoles with α,β-unsaturated acyl phosphonates by using a cinchonine derived squaramide as the catalyst were developed. A broad range of spirocyclic oxindole-γ-lactones/lactams could be obtained in moderate to excellent yields (up to 98%) with good to excellent diastereo- and enantioselectivities (up to >99:1 dr and 97% ee) under mild conditions. This work represents the first example about the α,β-unsaturated acyl phosphonates for the asymmetric construction of spirocyclic oxindoles.

  11. Skeletal Banding Pattern and Growth Rates of the Massive Coral Porites Lutea Edwards & Haime on the North Coast of Central Java, Indonesia

    OpenAIRE

    Supriharyono

    1998-01-01

    Growth rates (linear skeletal extension) and the timing of skeletal band formation were measured in 15 speciments of the massive coral. Porities lutea at three locations on the north coast of Central Java. The result of skeletal X-rayed indicate that timing of the high density (HD) and low density (LD) bands is synchronous at three locations. A one year growth is characterized by three HD bands, one of which is usually wider. Comparisons of the skeletal extention rates (X-ray radiography) ind...

  12. A critique of Michael L. Millenson's book, Demanding medical excellence: doctors and accountability in the information age, and its relevance to CRNAs and nursing.

    Science.gov (United States)

    Gunn, I P

    1998-12-01

    Michael L. Millenson's well-documented book, Demanding Medical Excellence: Doctors and Accountability in the Information Age, is a wake up call to both medicine and nursing for somewhat different reasons. Millenson decries the lack of scientific-based medical practice and medicine's failure to wake up due to its own historical studies. He cites data that 85% of current practice has not been scientifically validated despite medicine's claims of the physician-scientist. He outlines a historical chronology of advocacy for better practice based on concerns and studies that demonstrates significant differences in patient outcomes, adjusted for case mix, across hospitals studied. Millenson advocates the development of a broader base of benchmarking and best practices, reflected in clinical practice guidelines, recognizing the resistance of physicians to their use. He further advocates incorporating more fully information-age computers in the delivery of quality care by programming them to the tasks they are best suited for in informing and alerting us to flawed memories, orders, and abnormal laboratory and radiologic data. The relevance of Millenson's book to CRNAs and nursing in general is twofold: (1) He discusses the National Halothane Study and the subsequent Stanford Institutional Differences Study. The latter study confirmed what was found in the National Halothane Study concerning significant differences in patient outcomes across studied hospitals but did not address the role of the hospital's primary anesthesia provider, anesthesiologists, or CRNAs in these differences, as did the latter. He addresses the lack of publication and dissemination of the institutional outcome differences of these studies performed in the 1960s and 1970s, but he does not address the anesthesia provider portion of the Stanford Study. (2) While Millenson does mention nursing briefly and advocates its involvement in clinical practice guideline development, he does not discuss the

  13. Le Falstaff de Manfredo Maggioni et Michael Balfe : façonner un opéra italien pour le public anglais Adapting The Merry Wives of Windsor for the Italian Stage: Falstaff by Manfredo Maggioni and Michael Balfe

    Directory of Open Access Journals (Sweden)

    Céline Frigau

    2011-12-01

    Full Text Available Le Falstaff de Manfredo Maggioni et Michael Balfe constitue un cas à la fois exemplaire et unique de réécriture lyrique d’une œuvre de Shakespeare. Inspiré des Merry Wives of Windsor, l’opera buffa est écrit en 1838 pour le public de l’opéra italien de Londres, par un librettiste italien et un compositeur irlandais – une première dans un théâtre où l’on ne passe commande qu’auprès de maestri italiens. Des efforts de Maggioni et de Balfe résulte un véritable opéra italien qui respecte les codes structurels, les pratiques vocales et scéniques qui le rendent reconnaissable comme opera buffa sur la scène esthétique du temps. La question de la réécriture engage ici la réflexion sur les processus intimement liés de production et de réception précis, comme sur l’horizon d’attente du public londonien pour circonscrire les frontières d’une catégorie esthétique nommée « opéra italien » qui se définit aussi et peut-être avant tout loin de la péninsule, au contact de spectateurs non italophones, au fil d’échanges à l’échelle européenne.Based on Shakespeare’s Merry Wives of Windsor, Michael Balfe’s Falstaff, created in 1838 for London’s Italian opera audiences, was the work of an Italian librettist, Manfredo Maggioni, and an Irish composer, a first in a theatre where only Italian maestri were commissioned for new works. Balfe’s and Maggioni’s combined efforts resulted in a truly genuine Italian opera buffa. Not only is it sung in Italian but it also respects the structural codes, vocal and scenic practices which make it recognizable as an opera buffa on the aesthetic stage of the time, and above all on the English stage. The issue of rewriting implies here a reflection on the intimately linked processes of production and reception. Through the study of the libretto and score, its contextualization, as well as contemporary accounts, we will be concerned both with questioning the

  14. Spectroscopic Evidence for Covalent Binding of Sulfadiazine to Natural Soils via 1,4-nucleophilic addition (Michael Type Addition) studied by Spin Labeling ESR

    Science.gov (United States)

    Aleksandrova, Olga

    2015-04-01

    with different polarity. As shown by the spin labeling ESR experiment, molecules modeling SDZ were promptly bound to non-hydrolysable network of soil organic matter only via the aromatic amines that was accompanied by a prompt enlargement of humic particles binding aromatic amines, whereas binding of decomposition products of SDZ to humic acids of soil via the aliphatic amines was not observable. The ESR spectra obviously showed a single-phase process of covalent binding of the aromatic amines. Repeated washouts of labeled soil samples using distil water and ultrafiltration through the membrane of 5000 MWCO PES confirmed irreversible binding of the aromatic amines, and showed that via the aliphatic amines, binding of SDZ or decomposition products of SDZ to soil might also occur but reversibly and only to small soil molecules, which don't enter into the composition of non-hydrolysable part of soil organic matter. SL ESR experiments of different soils at the presence of Laccase highlighted that covalent binding of the aromatic amines to humic particles occurred in the specific hydrophobic areas of soil found as depleted in oxygen. All measured data evidenced that first, SDZ might be decomposed that allowed for measuring the same change of a paramagnetic signal of soil organic matter influenced by both aromatic and aliphatic amines as in the experiment of the interaction of soil with SDZ. Second, a decomposition product of SDZ with the aromatic amine might be bound to non-hydrolysable parts of soil organic matter under specific anaerobic conditions only via 1,4 - nucleophilic addition, Michael-type addition. Gulkowska, A., Thalmann, B., D., Hollender, J., & Krauss, M. (2014). Chemosphere, 107, 366 - 372. Müller, T., Rosendahl, I., Focks, A., Siemens, J., Klasmeier, J., & Matthies. (2013). Environmental Pollution, 172,180 - 185. Nowak, K.M., Miltner, A., Gehre, M., Schaeffer, A., & Kaestner, M. (2011). Environmental Science & Technology 45, 999 - 1006. Weber, E.J., Spidle

  15. Regele Mihai între „est” și „vest”. Percepții, poziționări, simboluri (King Michael between east and west. Perceptions, positionings, symbols

    Directory of Open Access Journals (Sweden)

    Alexandru MURARU

    2015-12-01

    Full Text Available The article investigates three strategic directions within the political perceptions of Romanian King Michael involving the East/West paradigm. The article will try to highlight the main positioning, both in Exile and the complicated recent history, immediately after the December 1989 events. King Michael’s relations with Western powers and attitude throughout Romania after 1989, the fate of Bessarabia as a direct „confrontation” between East -West and the significances of the „August 23” Act in reshaping the post-revolutionary memorial debate, represent three fundamental perspectives in understanding the „East” and „West” thinking of the Romanian monarch. These three themes, rich in meanings, have three major connotations: moral, geographic and memorials. Each of them are explained and decrypted with many examples, quotes, and historical and geographical references.

  16. A European prospective, randomized placebo-controlled doubleblind Study on the efficacy and safety of Dr Michaels® (also branded as Soratinex®) product family for stable chronic plaque psoriasis.

    Science.gov (United States)

    França, K; Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Wollina, U; Tirant, M; Novotny, F; Roccia, M G; Maximov, G K; Lotti, T

    2016-01-01

    Psoriasis is a chronic, inflammatory, recurrent, genetically determined dermatitis that affects the skin and joints. Many patients affected by this condition seek alternatives and complementary treatment options such as herbal medicines. In order to establish the safety of these products, trials, according to medical standards should be performed to provide the highest quality of data. The aim of this study was to assess the efficacy and safety of an Australian series of herbal skincare products [Dr. Michaels® (Soratinex®) skin-care products for psoriasis] for the management of stable chronic plaque psoriasis. We studied 142 patients (68 females and 74 males) with mild to moderate, stable, chronic plaque psoriasis and they were randomly assigned to either verum or control group. Exclusion criteria were: severe psoriasis, arthropathic psoriasis, intertriginous psoriasis, palmoplantar psoriasis, use of any antipsoriatic treatment and any medication which could influence or interfere with the course of the disease. Both groups consisted of a cleansing gel, an ointment and an oil blend (skin conditioner), packed in neutral bottles, used twice daily for all lesions except the scalp, for 8 weeks. As control products, we used compositions of well-known neutral ointments and medicinal bathing oil. Assessment, using the Psoriasis Activity Severity Index (PASI) scores, was done before treatment and after 2, 4, 6 and 8 weeks. Patient improvement was determined by the percentage reduction of the PASI scores. Statistical analysis was carried out using the Mann-Whitney-U Test with SPSS for Windows. Our investigation demonstrates that complementary methods can play a role in dermatologic therapy as long as they undergo standardised clinical trials and fulfil the basic requirements such as product safety and quality assurance. This study shows that Dr Michaels (Soratinex®) herbal skin-care products improve mild to moderate stable chronic plaque psoriasis significantly.

  17. Chairman of the DELL Board of Directors and Chief Executive Officer Michael S. Dell with CERN Director-General R. Heuer and in front of the ATLAS detector (centre) with ATLAS Deputy Spokesperson A. Lankford (left) and Information Technology Department Head F. Hemmer on 26th January 2010.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    Chairman of the DELL Board of Directors and Chief Executive Officer Michael S. Dell with CERN Director-General R. Heuer and in front of the ATLAS detector (centre) with ATLAS Deputy Spokesperson A. Lankford (left) and Information Technology Department Head F. Hemmer on 26th January 2010.

  18. Comment les fans réagissent-ils lors du décès de la célébrité ? Usages des communications et des médias sociaux dans le deuil de Michael Jackson

    OpenAIRE

    Courbet, Didier; Fourquet-Courbet, Marie-Pierre

    2012-01-01

    The authors conducted a qualitative survey of Michael Jackson fans' reactions to his death and their subsequent communication practices in order to better understand certain psychological and social aspects of fandom. They examine the uses of and roles played by interpersonal communications and social media during the period of mourning. Their analysis shows that a celebrity can play a socio-emotional mediating role between a fan and a loved one. The death of a celebrity brings up new identit...

  19. Direct targeted glycation of the free sulfhydryl group of cysteine residue (Cys-34) of BSA. Mapping of the glycation sites of the anti-tumor Thomsen-Friedenreich neoglycoconjugate vaccine prepared by Michael addition reaction.

    Science.gov (United States)

    Demian, Wael L L; Kottari, Naresh; Shiao, Tze Chieh; Randell, Edward; Roy, René; Banoub, Joseph H

    2014-12-01

    We present in this manuscript the characterization of the exact glycation sites of the Thomsen-Friedenreich antigen-BSA vaccine (TF antigen:BSA) prepared using a Michael addition reaction between the saccharide antigen as an electrophilic acceptor and the nucleophilic thiol and L-Lysine ε-amino groups of BSA using different ligation conditions. Matrix laser desorption ionization time-of-flight mass spectrometry of the neoglycoconjugates prepared with TF antigen:protein ratios of 2:1 and 8:1, allowed to observe, respectively, the protonated molecules for each neoglycoconjugates: [M + H](+) at m/z 67,599 and 70,905. The measurements of these molecular weights allowed us to confirm exactly the carbohydrate:protein ratios of these two synthetic vaccines. These were found to be closely formed by a TF antigen:BSA ratios of 2:1 and 8:1, respectively. Trypsin digestion and liquid chromatography coupled with electrospray ionization mass spectrometry allowed us to identify the series of released glycopeptide and peptide fragments. De novo sequencing affected by low-energy collision dissociation tandem mass spectrometry was then employed to unravel the precise glycation sites of these neoglycoconjugate vaccines. Finally, we identified, respectively, three diagnostic and characteristic glycated peptides for the synthetic glycoconjugate possessing a TF antigen:BSA ratio 2:1, whereas we have identified for the synthetic glycoconjugate having a TF:BSA ratio 8:1 a series of 14 glycated peptides. The net increase in the occupancy sites of these neoglycoconjugates was caused by the large number of glycoforms produced during the chemical ligation of the synthetic carbohydrate antigen onto the protein carrier. Copyright © 2014 John Wiley & Sons, Ltd.

  20. Strauss: Der Rosenkavalier - Suite / Michael Kennedy

    Index Scriptorium Estoniae

    Kennedy, Michael

    1990-01-01

    Uuest heliplaadist "Strauss: Der Rosenkavalier - Suite, Salome-Dance of the seven veils, Capriccio-Prelude, Intermezzo, Morgen Mittag um elf! Felicity Lott, Scottish National Orchestra, Neeme Järvi" Chandos ABRD 1397. ABTD 1397. CHAN 8758

  1. Mohamed S. Ftaiaba' and Michael D. Bentleyb

    African Journals Online (AJOL)

    Their structures have been estabiished by spectroscopic and chemical methods. They belong to the ring—C cleaved class of tetranortriterpenes. INTRODUCTION. Mafia is a genus consisting of shrubs, widely spread in Africa and the lndian Ocean islands. Me/ia volkensii Gilrke (Meliaceae) is found in the dry areas of East ...

  2. Michael Howard: Military Historian and Strategic Analyst.

    Science.gov (United States)

    1983-06-10

    Mozart and that seemed as good a reason as any to join the Foot Guards. One finds this alleged naivete by a Wellington man a bit hard to accept since...Paret learned from Howard in this regard. For the others, 22 Howard’s editorial pen and verbal criticism helped to mold dry prose into effective ...previously characterized his prose style and thereby made his contributions more effective . Above all the students recognize Howard’s willingness to take an

  3. 1260-IJBCS-Article- Michael Dike+

    African Journals Online (AJOL)

    hp

    -20.0 cm from four abandoned farmlands and a secondary forest regrowth in the months of August, September and October, 2008. The experiment was replicated twice at each site for each month. Sieving- floatation method was adopted and.

  4. 181-IJBCS-Article-Dr Michael Monanu

    African Journals Online (AJOL)

    RHUMSIKI

    ... where it was found growing on a bitter orange. It was properly identified at the Plant and Biotechnology. Centre of the University of Port Harcourt, with University of Port Harcourt Herbarium number as 481 (Collector's number 001). The leaves were carefully plucked, thoroughly washed and air dried. The dried leaves were.

  5. Obituary: Thomas Michael Donahue, 1921-2004

    Science.gov (United States)

    Gombosi, Tamás I.

    2004-12-01

    Thomas M. Donahue, one of the nation's leading space and planetary scientists and a pioneer of space exploration, died Saturday October 16, 2004, from complications following heart surgery. The Edward H. White II Distinguished University Professor of Planetary Science at the University of Michigan, Tom shaped space exploration through his scientific achievements and policy positions. His work started with the first use of sounding rockets following World War II and continued for almost 60 years. Tom was born in Healdton, Oklahoma on May 23, 1921 to Robert Emmet and Mary (Lyndon) Donahue. His father was a plumber in the oil fields when Tom was born (Healdton OK was an oil town) and worked as a plumber in Kansas City for a time. Tom grew up in Kansas City, graduating in 1942 from Rockhurst College in that city with degrees in classics and physics. His graduate work in physics at Johns Hopkins University was interrupted by service in the Army Signal Corps. He obtained his PhD degree in atomic physics from Hopkins in the fall of 1947. After three years as a post-doctoral research associate and assistant professor at Hopkins, Tom joined the University of Pittsburgh Physics Department in 1951. At Pittsburgh he organized an atomic physics and atmospheric science program that led to experimental and theoretical studies of the upper atmosphere of the Earth and other solar system planets with instruments flown on sounding rockets and spacecraft. He became Professor of Physics in 1959 and eventually Director of the Laboratory for Atmospheric and Space Sciences and the Space Research Coordination Center at the University. In 1960 he spent a sabbatical year on a Guggenheim Fellowship at the Service d'Aeronomie in Paris, which began collaborations with French colleagues that flourished for more than 40 years. In 1974 he became the Chairman of the Atmospheric and Oceanic Science Department, University of Michigan, a position he held until 1981. In 1986, he was named the Henry Russel Lecturer at the University of Michigan, the highest honor the University confers on a faculty member, and received the Atwood Award for excellence in research in 1994. Elected to the National Academy of Sciences in 1983 and to the International Academy of Astronautics in 1986, Tom was a Fellow of the American Geophysical Union and the AAAS, and received an honorary degree of ScD from Rockhurst College in 1981. The same year he was awarded the Arctowski Medal by the National Academy of Sciences and the John Adam Fleming Medal by the American Geophysical Union. He received the NASA Distinguished Public Service Medal, two NASA Public Service Awards, the Space Science Award of the American Institute of Aeronautics and Astronautics, and the National Space Club Science Award. From 1982 to 1988 he was Chairman of the Space Science Board of the National Research Council of the National Academy of Science, where he was a strong advocate for unmanned space science missions within the federal space budget. He also served on numerous governmental, NRC, and National Academy of Science advisory boards and committees, and was an officer on the boards of several university consortia, such as the University Corporation for Atmospheric Research and the Universities Space Research Association. He recently served terms as chairman of the Visiting Committee for the Space Telescope Science Institute, the Arecibo Advisory Board and Visiting Committee, the Max Planck Institute for Aeronomy, and the Committee to Visit the Department of Earth and Planetary Sciences at Harvard University. He was Chairman of the Committee on Public Policy of the American Geophysical Union and authored more than 200 research publications. Tom's influence in space exploration spanned many decades and diverse projects. He was an experimenter or interdisciplinary scientist on the orbiting Geophysical Observatory Missions, Apollo-17, Apollo-Soyuz, Voyager, Pioneer Venus Multiprobe and Orbiter, Galileo, Comet Rendezvous Asteroid Flyby, and Cassini. Based on observations by the Pioneer Venus entry probe, he concluded that Venus once had an ocean before a runaway greenhouse effect led to its current state. Analyzing similar data from Martian meteorites, he again argued for a substantial Martian ocean, anticipating the current series of missions to Mars. In these and many other cases he laid the foundation for our current understanding of planetary atmospheres. In 1999, Tom described his career this way, "I parlayed my training in atomic physics into a faculty position at Pitt, doing research in aeronomy and laboratory studies of atomic physics. This led to rocket and satellite exploration of the upper atmosphere of Earth in the 60s and spacecraft exploration of Mars, Venus and the Outer Planets beginning in the 70s. Along the way my students, post-docs and I were deeply involved in the problem of anthropogenic destruction of the stratospheric ozone in the early 70s. This led to my continuing interest in global change." Throughout his life Tom retained a keen interest in the history of his family in Ireland, as his mother and grandfather both emigrated from County Kerry. He studied oral and written sources, writing as early as 1942 on the family and the early history of the Eóghanachta Rathleinn. Recently his efforts supported the establishment of the international O'Donoghue society, in particular spearheading a project that continues to reveal fresh detail about family migrations from the High Kings to the Cromwellian period. Tom brought his powerful intellect and drive to a broad range of lifelong passions beyond science. Fluent in several languages, from classical Greek to modern Irish, he was also widely read in American, Irish and French history and literature, and was an exacting student of French wine. He loved classical and folk music, often singing hundreds of songs for his family in keys only he knew. A devotee of tennis, he continued playing weekly matches until early 2004, and was able to attend one last ceremony honoring him when the University of Michigan and his home department, awarded his friend and fellow Space Science Board chair, Lennard Fisk, the "Thomas M. Donahue Collegiate Professor of Space Science." He is survived by his wife of 54 years, Esther McPherson Donahue of Ann Arbor, Michigan; their three sons -- Brian of Boston MA, Kevin of Berkeley CA and Neil of Pittsburgh PA; six grandchildren; a brother, Robert Donahue, and sister, Mary Marshall, both of Missouri.

  6. Backlash: A Response to Michael Clyne.

    Science.gov (United States)

    Ager, Dennis

    1997-01-01

    A response to an article on multiculturalism and the status of community languages in Australia focuses on the issue of "backlash" against public policy for immigrants, and discusses the link between language planning and social planning. The role of elites and "counterelites," interest and pressure groups, in the successful…

  7. Letter from Little Lithuania / Michael Tarm

    Index Scriptorium Estoniae

    Tarm, Michael

    2004-01-01

    Autor teeb ülevaate Eesti, Läti, Leedu toodetest ja kaubamärkidest USA turul, Baltimaadesse puutuva kajastamisest USA meedias ning USA avalikkuse teadlikkusest Balti riikidest, sportlastest ja kultuuritegelastest

  8. "Salvadorskii stsenarii" / Michael Hirsh, John Barry

    Index Scriptorium Estoniae

    Hirsh, Michael

    2005-01-01

    USA kaitseministeerium on asunud otsima lahendusi Iraagi vastupanuvõitlejate mahasurumiseks. Pentagonis on arutlusel plaan, mis kuulus Ronald Reagani administratsiooni salastrateegia hulka võitluses partisanide vastu Salvadoris

  9. Uued lahendused kliendisuhete halduses / Michael Stimson

    Index Scriptorium Estoniae

    Stimson, Michael

    2008-01-01

    Autor kirjeldab klienditeeninduse parandamist kliendihaldustarkvara Microsoft Dynamics CRM kasutamise abil. Skeem: Täiustatud teeninduskogemus. Lisa: Kliendihaldus algas kümmekond aastat tagasi; CRM aitab lahendada riigiasutuste probleeme

  10. 1260-IJBCS-Article- Michael Dike+

    African Journals Online (AJOL)

    hp

    A 3 x 5 Factorial Experiment in Randomized Complete Block design Experiment was used to study seeds stocked in soils of four abandoned farmlands and a secondary forest regrowth at Umukabia, Nigeria. Soil monoliths 25.0 x 25.0 x 10.0 cm were collected from the depths 0-10 cm and 10.0-20.0 cm from four abandoned ...

  11. Introduction from Michael Lang. Guest Editor

    OpenAIRE

    Lang, Michael

    2015-01-01

    This special issue of the Journal is devoted to a selection of articles from a number of people who presented papers and workshops at the International Conference held at Maynooth University in September, 2014. The overarching focus of the presentations was expressed in the conference title, Creative Responses to Conflict through Mediation and Restorative Practice. The exceptionally diverse mixture of professionals—presenters and participants—represented a wide range of practitioners, res...

  12. In Conversation: Michael Quinn Patton | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-02-09

    Feb 9, 2011 ... One agriculture project grew a bean that cooked faster so it would use less fuel — and therefore you would partly reduce deforestation. But there was a lot of resistance to adopting it. Part of the resistance was because one of the few times women in this culture were able to socialize with each other was ...

  13. Kuidas valida õige juhtimisstiil / Michael D. Watkins

    Index Scriptorium Estoniae

    Watkins, Michael D.

    2009-01-01

    Autor tutvustab enda välja töötatud STARSi mudelit, mis kirjeldab viite tüüpilist olukorda, millesse juhid võivad üleminekuolukorras sattuda: käivitamine, päästmine, kiire kasv, ümberkorraldamine ning edu hoidmine. Lisa: Idee praktikas. Tabel: STARSi mudel; Üks juhtimisstiil ei sobi kõigile

  14. Ameerika ei ole Jaapan / Michael Craig

    Index Scriptorium Estoniae

    Craig, Michael

    2002-01-01

    Kuidas Jaapani ärimees Minoru Isutani 1981. aastal ei arvestnud, et ameeriklased ei osta golfiklubi eluaegset liikmekaarti 750 000 dollari eest, ning kaotas USA kuulsaima Pebble Beachi golfiväljaku. Katkend raamatust "50 parimat ja halvimat tehingut läbi aegade"

  15. PALMER (Michael), Freud and Jung on Religion

    OpenAIRE

    Maître, Jacques

    2009-01-01

    M.R appartient à l’École de Théologie de Westminster College (Oxford). Il a rédigé un ouvrage d’enseignement en deux parties présentant les thèses sur la religion soutenues respectivement par Freud et Jung, qui se trouvent critiqués vigoureusement sans que l’auteur prenne parti pour l’un ou l’autre. Une interprétation caricaturale du concept d’illusion et un recours à Winnicott permettent ici au théologien de glisser hors du filet freudien. En revanche, la sympathie de nombreux théologiens po...

  16. Michael Nyman, (filmi)muusika Superman / Michael Nyman ; interv. Harry Liivrand

    Index Scriptorium Estoniae

    Nyman, Michael, 1944-

    2000-01-01

    M. Nyman (s. 1944) oma uudisteosest "The Commissar Vanishes" (multimeediana kujundas C. Kondek, teose aluseks D. Kingi raamat Stalini ajal A. Rodtšenko poolt retušeeritud ja ülemaalitud kommunistide fotodest), koostööst P. Greenawayga. H. Liivrand ja A. Remme M. Nymanist, tema loomingust

  17. Determinants of Private Investment in Tanzania | Michael | African ...

    African Journals Online (AJOL)

    This article investigates the determinants of private investment in Tanzania using Error Correction Model and employing time series data for the period 1975 – 2010. The results show that public investment, GDP growth and credit to private sector are important in explaining growth of private investment but there is no enough ...

  18. Eelarvesõltumatuse lõpp / Michael Spence

    Index Scriptorium Estoniae

    Spence, Michael, 1943-

    Nobeli majanduspreemia laureaat märgib, et kui EL soovib rahaliitu, kus riigilaen on riskide osas suhteliselt ühtlane, peab ka eelarvedistsipliin olema sama ühtlane. Seega vajatakse jõulisemat mehhanismi, et šokkidele reageerida

  19. The Lancet Oncology's Cancer Control in Africa | Michael | Annals of ...

    African Journals Online (AJOL)

    In April 2013 the Lancet Oncology published a series on cancer control in Africa comprising 7 papers (Lancet Oncology vol 14 number 4). The significance of these papers to Africa's attempts at tackling the rapidly rising prevalence of cancer cannot be over-emphasized. Potentially, these papers will form the basis of ...

  20. Estonian leader voices worry over Russia / Michael Abramowitz

    Index Scriptorium Estoniae

    Abramowitz, Michael

    2006-01-01

    USA presidendi George W. Bushi 28. novembril 2006. a. toimunud Eesti visiidi ajal oli presidentide vahelise vestluse läbivaks probleemiks Venemaa aina kasvav autokraatia ja despotism, mis on välja viinud juba esimeste arvatavate poliitmõrvadeni Kremli tuliste kriitikute Anna Politkovskaja ja Aleksandr Litvinenko näol

  1. The Evolution of Anti-Retroviral Therapy in Nigeria | Michael ...

    African Journals Online (AJOL)

    Areas of research highlighted are the Monitoring of ART, adherence to ART, and highly active anti-retroviral therapy in Nigeria. From the first report on the PUBMED search by Akanmuet al from Lagos in 2001 to reports in 2013, it is undeniable that HIV scientists in Nigeria have produced a good number of very informative ...

  2. Shostakovich: The Orchestral Songs Vol. 2 / Michael Tanner

    Index Scriptorium Estoniae

    Tanner, Michael

    1996-01-01

    Uuest heliplaadist "Shostakovich: The Orchestral Songs Vol. 2: Six Romances on texts by Japanese poets, Op. 21. Six Poems on Marina Tsvetayeva, Op. 143. Suite on Verses of Michelangelo, Op. 145. Gothenburg Symphony Orchestra, Neeme Järvi". DG 447 085-2GH (71 minutes:DDD)

  3. Expanding Your Coverage of Neuroscience: An Interview with Michael Gazzaniga

    Science.gov (United States)

    Rasmussen, Erin B.

    2006-01-01

    Erin Rasmussen is an Assistant Professor in the Department of Psychology at Idaho State University where she teaches learning, behavioral pharmacology, senior seminar, and introductory psychology. She received her MS and PhD in experimental psychology (with a minor in behavioral pharmacology and toxicology) from Auburn University. She taught at…

  4. Michael Kagan on behalf of the ATLAS Collaboration

    Indian Academy of Sciences (India)

    The measurement of the W ± Z production cross-section in proton–proton interactions at s = 7 TeV is reported from the ATLAS experiment at the Large Hadron Collider using 1.02 fb-1 of data. The measurement is derived from events with leptonically decaying bosons with electrons, muons, and missing energy in the final ...

  5. Book appraisal: history of dentistry in Nigeria | Michael ... - Ibadan

    African Journals Online (AJOL)

    The book appraised in this edition of Chronicles of Medical History, History of Dentistry in Nigeria, is a product of many years of painstaking research. The Author, Professor Eyitope Ogunbodede, has put together an excellent book that is a great work of art. Dentistry is one of the first specialties in medicine with a very long ...

  6. Determination of solar insolation in Michael Okpara University of ...

    African Journals Online (AJOL)

    With this figure of insolation, Umudike falls within the high insolation zones of the globe. This is in accordance with NASA (2002) report. The community therefore has enough radiation to support not only agriculture but also high level solar projects. Keywords: Solar radiation, daily insolation, photoresistance, insolation figure ...

  7. Timetable set for new transport development / Michael West

    Index Scriptorium Estoniae

    West, Michael

    2003-01-01

    Kuna Rail Baltica ja Via Baltica projektid on stagneerunud, oodatakse uuelt, multimodaalselt transpordikoridorilt (maanteed, raudteed, sadamad) mitmekülgsemaid võimalusi ühendamaks Baltimaid Poola ja Euroopa Liidu liikmesriikidega

  8. Linnadisaini lõpp(eesmärgid) / Michael Sorokin

    Index Scriptorium Estoniae

    Sorokin, Michael

    2008-01-01

    Autori arvates on linnadisain (urban design) jõudnud tupikusse. Ta on järjest vähem võimeline leidma leidlikke lahendusi linnade ja linnakodanike morfoloogilistele, funktsionaalsetele ja inimlikele vajadustele. Samal ajal kui ülesanded muutuvad keerukamaks ja pakilisemaks, on eriala peavoolustunud, muutudes potensiaalselt laiast ja lootusrikkast kontseptuaalsest kategooriast järjest enam paindumatuks, piiravaks ja igavaks vanade tavade järgimiseks

  9. The Tallinntellect / Toomas Hendrik Ilves ; intervjueerinud Michael Weiss

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2013-01-01

    Vene-USA poliitilistest suhetest, Eesti säästupoliitikast, USA käitumisest totalitaarsete režiimidega, presidendi lemmikkirjanik Vladimir Nabokovist ning praeguste poliitikute endisest kuulumisest kommunistlikku parteisse

  10. Hollybrook Lodge, St Michael's Estate, Bulfin Road, Inchicore, Dublin 8.

    LENUS (Irish Health Repository)

    Mac Giolla Phadraig, Caoimhin

    2014-01-01

    This study aimed to generate prioritised goals for oral health services for people with disabilities as a first step in meeting the need for evidence based oral health services for people with disabilities in Ireland.

  11. Rezension: Reiner Keller & Michael Meuser (Hrsg.) (2010). Körperwissen

    OpenAIRE

    Lehn, Dirk Vom

    2012-01-01

    Over recent years, the new sociology of knowledge has become increasingly interested in issues and debates about the ways in which the body features in people's actions and experience of the social world—debates that over the past two decades have also arisen within the sociology of the body. The edited collection reviewed here is based on the contributions to a conference jointly organised in 2010 by two sections of the German Sociology Association's (DGS): the section "Sociology of Knowledg...

  12. Dr. O.S Michael Department of Pharmacology and Therapeutics ...

    African Journals Online (AJOL)

    better understanding of human physiology and was the earliest explanation until Miguel Servet (1553). William Harvey was appointed physician to St. Bartholomew's hospital in 1609 and Lumieian lecturer at the College of Physicians. In 1658 he published his celebrated treatise, Exercitatio Anatomica de Motu Cordis.

  13. Streikverbot für Beamte? / Michael Kawik

    Index Scriptorium Estoniae

    Kawik, Michael

    2016-01-01

    Riigiametnike streigiõiguse piiramisest põhiseaduse artikli 33 lg 5 tähenduses ja Saksa konstitutsioonikohtu lahendis (27.02.2014); Euroopa Inimõiguste Kohtu praktika mõjust streigiõigusega seotud arengutele

  14. Biomimetics: The early years | Michael | Annals of Ibadan ...

    African Journals Online (AJOL)

    biomimicry is the imitation of the models, systems, and elements of nature for the purpose of solving complex biological puzzles. Insights into biological processes have already resulted in new discoveries that are having immediate clinical applications. From the initial studies that were driven by anti-cancer objectives, ...

  15. Speculating on Childhood and Time, with Michael Ende's "Momo" (1973)

    Science.gov (United States)

    Duhn, Iris

    2016-01-01

    Childhood and time are closely linked concepts in education. Childhood as a modern domain is a cornerstone of the human narrative of being in time, with birth as the beginning and death as the end. A newborn child marks new beginnings and hope for the future, and geopolitically early childhood education is now seen as a cornerstone for building…

  16. catalysis of the michael reactions by n,n'-dimethylaminopropyl

    African Journals Online (AJOL)

    a

    . DERIVATISED MICELLE TEMPLATED SILICA: EFFECTS OF SOLVENT AND. CATALYST LOADING. J.E.G. Mdoe1*, J.H Clark2 and D.J. Macquarrie2. 1Department of Chemistry, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam,.

  17. Barber. Symphony N 1, Op. 9 / Michael Oliver

    Index Scriptorium Estoniae

    Oliver, Michael

    1991-01-01

    Uuest heliplaadist "Barber. Symphony N 1, Op. 9. The School for Scandal Overture, Op. 5 Beach. Symphony in E minor, Op. 32, "Gaelic". Detroit Symphony Orchestra /Neeme Järvi" Chandes cassette ABTD 1550; CD CHAN 8958 (72 minutes)

  18. Language Maintenance or Language Fetishisation? A Response to Michael Clyne.

    Science.gov (United States)

    Kelly-Homes, Helen

    1997-01-01

    A response to an article on multiculturalism and the status of community languages in Australia argues that efforts to maintain any minority language within immigrant communities should be tempered by critical assessment of what is to be achieved, for whom, and why. The original article's author responds. (MSE)

  19. Citing George Orwell, Michael Radu states that 'those who control ...

    African Journals Online (AJOL)

    visser

    also the first capture of Russian military personnel by the South African forces on the same occasion,35 proving Soviet combat involvement in. Angola to the Western world, was, of course, of great political significance. Milestones of Bravery or Heroic Sacrifice. Milestones of bravery, heroic sacrifice or great loss of human life ...

  20. Strauss: Metamorphosen for 23 solo strings / Michael Kennedy

    Index Scriptorium Estoniae

    Kennedy, Michael

    1990-01-01

    Uuest heliplaadist "Strauss: Metamorphosen for 23 solo strings, Tod und Verklärung, Op. 24, Drei Hymnen, Op.71. Felicity Lott (sop.), Scottish National Orchestra, Neeme Järvi" Chandos ABRD 1374. ABTD 1374. CHAN 8734

  1. Hispanos en la EPA: Michael González

    Science.gov (United States)

    La diversidad de la fuerza laboral es importante para la Agencia de Protección Ambiental de EE.UU. (EPA, por sus siglas en inglés). Los empleados hispanos de la EPA contribuyen diariamente hacia la protección de la salud y el medio ambiente.

  2. The Michael-Adler report (1933): criminology under the microscope.

    Science.gov (United States)

    Goff, Colin; Geis, Gilbert

    2008-01-01

    This paper details the responses made by social scientists as well as criminal justice practitioners during 1932 to a study focusing on the status of criminology by the Bureau of Social Hygiene. These responses ultimately led to the publication of the controversial Crime, Law and Social Science (1933), which gave much-needed direction to the development of criminology. Despite the importance of these responses to the creation of criminological thought, only one (by Edwin H. Sutherland) has previously been published. Examining the responses of all of the individual participants in the project gives a clearer picture of controversies and changes which ultimately occurred as the field of criminology gradually became institutionalized as an academic discipline.

  3. Mida roheline tarbija tahab / Catherine Roche ; intervjueerinud Michael S. Hopkins

    Index Scriptorium Estoniae

    Roche, Catherine, 1977-

    2009-01-01

    2008. a. tehtud uuringust, mille abil selgitati välja, mis põhjustel inimesed eelistavad tarbimisel rohelist tootevalikut. Skeemid: Valmisolek maksta rohelise eest rohkem sõltub tootekategooriast ja tajutavatest eelistest; Teadlikkus ja valik

  4. Book appraisal: history of dentistry in Nigeria | Michael | Annals of ...

    African Journals Online (AJOL)

    The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader). If you would like more information about how to print, save, and work with PDFs, Highwire Press provides a helpful Frequently Asked Questions about PDFs.

  5. Domino Knoevenagel/Michael synthesis of 2, 2'-arylmethylenebis (3 ...

    Indian Academy of Sciences (India)

    dimethyl-2-cyclohexen-1-one) derivatives catalyzed by silica-diphenic acid and their single crystal X-ray analysis. RUPALI VAID MONIKA GUPTA RAJNI KANT VIVEK K GUPTA. Regular Article Volume 128 Issue 6 June 2016 pp 967-976 ...

  6. Chronicles of medical history in Africa | Michael | Annals of Ibadan ...

    African Journals Online (AJOL)

    She obtained the M.B.B.S. degree in 1930 carting away the best prizes. She went on to pursue a successful postgraduate medical training in Obstetrics and Gynecology, and later in Surgery. She worked briefly as a general physician in 1933 before traveling to India where she became a lecturer and rose to the position of ...

  7. L. Sumera: Symphony No. 5 / Michael Scott Rohan

    Index Scriptorium Estoniae

    Rohan, Michael Scott

    1997-01-01

    L. Sumera: Symphony No. 5; Music for Chamber Orchestra, In memorian. Malmö Symphony Orchestra / Paavo Järvi. BIS CD-770. 64-35 DDD; Various. Searching for Roots - music from Estonia. Virgin VC 5 43242 2; 71: 34 DDD

  8. First reports of clinical pharmacokinetics in Nigeria | Michael ...

    African Journals Online (AJOL)

    It is the basis of therapeutic drug monitoring with the ultimate goal of keeping drugs safe. This branch of pharmacology has become the most relevant to the sub-specialty of clinical pharmacology. First reports of Clinical Pharmacokinetics in Nigeria can be credited to two gifted Nigerians, Prof Ayodele O. Iyun and Prof Lateef ...

  9. USA kliimamuutuse vastu: Kopenhaagenis ja edaspidi / Michael C. Polt

    Index Scriptorium Estoniae

    Polt, Michael C., 1954-

    2009-01-01

    Käsitledes Kopenhaageni kliimakonverentsi, märgib USA Eesti-suursaadik, et USA on valmis paika panema eesmärgi vähendada kohalike seadustega kooskõlas 2020. aastaks kasvuhoonegaaside heitmete emissiooni tasemeni, mis oleks 17% väiksem 2005. aasta tasemest

  10. The impact of Brexit on UK labour law / Michael Ford

    Index Scriptorium Estoniae

    Ford, Michael

    2016-01-01

    Brexiti mõjust Suurbritannia tööõigusele, töötajate õigustele. Suurbritannia ajaloolisest hoiakust Euroopa Liidu tööõigusesse, EL tööõiguse mõjust Suurbritannia töötajate õigustele. Brexiti järgsest Suurbritannia tööõiguse võimalikest suundadest

  11. The Search for the Genetic Basis of African Keloids | Michael ...

    African Journals Online (AJOL)

    Keloids are benign hyperproliferative growths of dermal fibroblasts characterized by excessive, and often times extensive, deposition of extracellular matrix components especially collagen and fibronectin. First described in the Edward Smith papyrus in Egypt around 1700 BC, the aetiopathogenesis of the disease has ...

  12. an assessment of Michael Tye's and David Chalmers' criticisms of ...

    African Journals Online (AJOL)

    user

    However, most of the recent discourses on the mind-body problem have been under the distinction and opposition between dualism and physicalism (Crane 2001:43). Physicalism, in a general sense, is the philosophical position that the universe and all in it are entirely physical. It is the view that the world is constituted of ...

  13. Ameerika ostis kullatüki / Michael Craig

    Index Scriptorium Estoniae

    Craig, Michael

    2002-01-01

    Ameerika Ühendriigid ostsid 1867. aastal Venemaa käest Alaska. Tehingut peeti suurimaks äparduseks, kuni sealt avastati kulda ja naftat. Katkend raamatust "50 parimat ja halvimat tehingut läbi aegade"

  14. Oraaklus tõi sajad miljonid / Michael Craig

    Index Scriptorium Estoniae

    Craig, Michael

    2002-01-01

    Kolm valitud juhtumit autori raamatust "50 parimat (halvimat) tehingut läbi aegade": Cain Chemical (keemiaettevõte), MP3. com (veebilehekülg), Hotmail (e-posti teenuste pakkuja). Kõigi kolme juhtumi puhul tõid ettevõtted sisse hiigelkasumeid tänu õigele ajastusele või omanike võimele näha ette arenguid oma valdkonnas

  15. Determinants of Private Investment in Tanzania | Michael | African ...

    African Journals Online (AJOL)

    The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader). If you would like more information about how to print, save, and work with PDFs, Highwire Press provides a helpful Frequently Asked Questions about PDFs.

  16. On the Michael addition of water to C = C bonds

    NARCIS (Netherlands)

    Chen, B.

    2015-01-01

    ?-Hydroxy carbonyl compounds are an important class of compounds often found as a common structural motif in natural products. Although the molecules themselves look rather simple, their synthesis can be challenging. Water addition to conjugated C = C bonds opens up a straightforward route for the

  17. The Scientist as Byronic Hero: Michael Frayn's "Copenhagen"

    National Research Council Canada - National Science Library

    Staub, August W

    2002-01-01

    .... Frayn's play "Copenhagen" is set in September 1941, when Werner Heisenberg, who developed the "uncertainty principle," visited his mentor, Neils Bohr, the articulator of the Copenhagen Interpretation...

  18. Michael Winkler普通教育學之探究 Inquiry into Michael Winkler'’s General Pedagogy

    Directory of Open Access Journals (Sweden)

    梁福鎮 Frank Liang

    2015-12-01

    Full Text Available 本文採用教育詮釋學方法,進行Winkler普通教育學的探究。Winkler是「反思教育學」的代表人物,對於德國閱讀教育的推動、古文中學的改革、反思教育學的形成、社會教育理論的建立和社會教育工作的實施,具有重要貢獻,被列為德國當代著名的教育學家。其普通教育學的主要內涵包括教育概念的釐清、陶冶概念的分析、理論與實踐的關係、教育學說的批判和普通教育學的課題。 Winkler的普通教育學是一種反思教育學,能夠釐清教育概念的真正意義,瞭解陶冶概念的歷史演變,闡明教育理論與實踐的關係,批判錯誤的教育學說,明白普通教育學的課題。但是其普通教育學也存在著教育觀點否定兒童本性的價值、教育理論忽略跨學科的論述和教育活動結構仍然有待說明等問題。儘管如此,Winkler的觀點依然可以作為我國建立教育理論和解決教育問題的參考,對於我 國教育學術而言,具有促進普通教育學成為核心學科、提供教師作為實施教學的指引和解決後現代社會中的教育問題等啟示,相當值得我們加以重視! This article adopted method of educational hermeneutics to investigate M.Winkler’s general pedagogy. Winkler is not only the delegate of reflective pedagogy, but also a famous educator in modern Germany. He made a great contribution to the promotion of reading education, reform of high schools, formation of reflective pedagogy, establishment of social pedagogy theories and implementation of social work. The main contents of Winkler’s general pedagogy include clarification of the concept of education, analysis of the concept of cultivation, relation between theories and practice, critique of educational doctrines and missions of general pedagogy. Winkler’s general pedagogy is a reflective pedagogy. It has the following advantages: first, clarifying the concept of general pedagogy; second, understanding historical development of the concept of cultivation; third, explaining the relation between educational theories and practice; fourth, criticizing mistakes of educational doctrines; fifth, understanding the missions of general pedagogy. Nevertheless, it also contains the following problems: first, it denies the natural value of children; second, it neglects the discourse across disciplines; third, it needs more explanation about the structure of educational activities. Winkler’s general pedagogy can be considered as a reference for the establishment of educational theories and the solutions to educational problems. It can help us to promote general pedagogy as a core subject, and provide teachers with a guide to instructional implementation and a solution for educational problems in the postmodern society. Winkler’s general pedagogy deserves more academic attention.

  19. Disease: H00696 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00696 Haim-Munk syndrome; Prepubertal periodontitis (PPP) Haim-Munk syndrome is a... rare autosomal recessive disorder of keratinization characterized by palmoplantar hyperkeratosis and marked periodontitis... acroosteolysis. Prepubertal periodontitis (PPP) is a rare and rapidly progressiv

  20. Michael E. Bonine, Abbas Amanat and Michael Ezekiel Gasper (Ed.), Is There a Middle East?: The Evolution of a Geopolitical Concept

    OpenAIRE

    NAKİP, TAHİR

    2014-01-01

    maneuvers did not reject his demand but kept him on hold, as Lord Kitchener recommended not alienating the Arabs (p.61). Not informing Hussein, Britain made a secret agreement with France; Sykes-Picot Agreement regarding the division of the Middle East (p.63). On the other hand, for the negotiations

  1. Disease: H00696 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00696 Haim-Munk syndrome; Prepubertal periodontitis (PPP) Haim-Munk syndrome is a ...rare autosomal recessive disorder of keratinization characterized by palmoplantar hyperkeratosis and marked periodo...acroosteolysis. Prepubertal periodontitis (PPP) is a rare and rapidly progressive... disease of young children that results in destruction of the periodontal support of the primary dentition. ...Cooper M, Yassin OM, Nusier M, Walker S Localisation of a gene for prepubertal periodontitis to chromosome 1

  2. Paul P. Mebe“, John A. Findlay”, Michael D. Stern“ and ML Givnei'.

    African Journals Online (AJOL)

    Interest in steroid chemistry arises from significant rating that these compounds have been accorded in medicine. Commercial research on steroid is focused on finding more potent, long acting synthetic drug analogues, possessing essential pharmacological properties. Our interest in this research arises from the report that ...

  3. A designated centre for people with disabilities operated by St Michael's House, Dublin 17

    LENUS (Irish Health Repository)

    Prasad, Babu R

    2012-01-20

    Abstract Background The inherent toxicity of unmodified Quantum Dots (QDs) is a major hindrance to their use in biological applications. To make them more potent as neuroprosthetic and neurotherapeutic agents, thioglycolic acid (TGA) capped CdTe QDs, were coated with a gelatine layer and investigated in this study with differentiated pheochromocytoma 12 (PC12) cells. The QD - cell interactions were investigated after incubation periods of up to 17 days by MTT and APOTOX-Glo Triplex assays along with using confocal microscopy. Results Long term exposure (up to 17 days) to gelatinated TGA-capped CdTe QDs of PC12 cells in the course of differentiation and after neurites were grown resulted in dramatically reduced cytotoxicity compared to non-gelatinated TGA-capped CdTe QDs. Conclusion The toxicity mechanism of QDs was identified as caspase-mediated apoptosis as a result of cadmium leaking from the core of QDs. It was therefore concluded that the gelatine capping on the surface of QDs acts as a barrier towards the leaking of toxic ions from the core QDs in the long term (up to 17 days).

  4. Michael Parki lühikest elu saadavad ülistussõnad / Tõnu Kees, Katre Kees

    Index Scriptorium Estoniae

    Kees, Tõnu, 1954-

    2006-01-01

    Vt. ka Postimees : na russkom jazõke 21. juuni, lk. 2. Markko Märtini kaardilugeja mälestusmonumendi avamine tõi eile Tallinna viis autoralli maailmameistrit samuti Parki lese ja lapsed, oodatust vähemaks jäi aga hukkunud võidusõitjale austust avaldama tulnud fännide armee

  5. A designated centre for people with disabilities operated by St Michael's House, Dublin 14

    LENUS (Irish Health Repository)

    O'Caoimh, Rónán

    2015-09-01

    Few case-finding instruments are available to community healthcare professionals. This review aims to identify short, valid instruments that detect older community-dwellers risk of four adverse outcomes: hospitalisation, functional-decline, institutionalisation and death. Data sources included PubMed and the Cochrane library. Data on outcome measures, patient and instrument characteristics, and trial quality (using the Quality In Prognosis Studies [QUIPS] tool), were double-extracted for derivation-validation studies in community-dwelling older adults (>50 years). Forty-six publications, representing 23 unique instruments, were included. Only five were externally validated. Mean patient age range was 64.2-84.6 years. Most instruments n=18, (78%) were derived in North America from secondary analysis of survey data. The majority n=12, (52%), measured more than one outcome with hospitalisation and the Probability of Repeated Admission score the most studied outcome and instrument respectively. All instruments incorporated multiple predictors. Activities of daily living n=16, (70%), was included most often. Accuracy varied according to instruments and outcomes; area under the curve of 0.60-0.73 for hospitalisation, 0.63-0.78 for functional decline, 0.70-0.74 for institutionalisation and 0.56-0.82 for death. The QUIPS tool showed that 5\\/23 instruments had low potential for bias across all domains. This review highlights the present need to develop short, reliable, valid instruments to case-find older adults at risk in the community.

  6. Ippolito Albertini and Michael Albertus: disparate old and innovative theories on dropsy and edema.

    Science.gov (United States)

    Timio, Mario; Capodicasa, Enrico

    2002-07-01

    The concept of edema and dropsy as a part of heart and renal failure developed in the 17th and 18th centuries with the observations of Albertini, who realized that two clinical entities were derived from the blood rather than the tissues. Albertus, who lived in the same period, was the last physician to interpret fluid accumulation according to the old, scholastic and dogmatic procedures of medicine. The fundamental concepts of Albertus held little in addition to the classification and categories of the physicians of the Middle Ages. Bloody congestions were distinguished from stagnation: the former have the purpose of reducing superfluites of blood and occurred in plethoric patients. Plethora in turn is caused by the ancient villain, inculpated since Hippocrates and Galen: suppressed hemorrhoids, suppressed menstrual evacuation and cutaneous eruption driven inward. Because of its suppression, transfer of blood occurs toward the chest, which impedes thoracic expansion and contraction, then asthma and dyspnea occur. On the contrary, Albertini with his clinical and autoptic observations and pronouncements filled in the anatomical and clinical picture of fluid accumulation and created the rudiments of diagnostic criteria. Edema, dropsy, asthma, dyspnea were, according to Albertini, the signs and symptoms of heart and renal failure. Albertini was the first to point out that dyspnea is apt to arise with special rapidity when a lesion occurs in the left atrial chamber and ventricle and by implication the mitral valve. In modern physiopathological terms, he discovered the picture of pulmonary edema. To this important discovery, he added a number of extremely important comments: changes in the respiratory organs are secondary to changes in the cardiovascular system; edema that is accompanied by dyspnea also affects the viscera, most especially the lungs, and finally dropsy of the lungs must be differentiated anatomically and clinically from dropsy of the chest (hydrothorax). In other words, he depicted the anatomical and clinical picture of congestive heart failure in modern terms. Copyright 2002 S. Karger AG, Basel

  7. A designated centre for people with disabilities operated by St Michael's House, Dublin 5

    LENUS (Irish Health Repository)

    Moloney, Niamh

    2010-01-01

    BACKGROUND: Work related upper limb disorders constitute 45% of all occupational diseases and are a significant public health problem. A subgroup, non specific arm pain (NSAP), remains elusive in terms of understanding its pathophysiological mechanisms with its diagnosis based on the absence of specific clinical findings. One commonly proposed theory is that a neural tissue disorder is the primary dysfunction in NSAP and findings from previous studies lend some support to this theory. However, it is not clear if changes identified are simply a consequence of ongoing pain rather than due to specific neural changes. The presence of neuropathic pain has been investigated in several other musculoskeletal conditions but currently, there is no specific diagnostic tool or gold standard which permits an unequivocal diagnosis of neuropathic pain. The purpose of this study is to further describe the somatosensory profiles in patients with NSAP and to compare these profiles to a group of patients with MRI confirmed cervical radiculopathy who have been previously classified as having neuropathic pain. METHODS\\/DESIGN: Three groups of participants will be investigated: Groups 1 and 2 will be office workers with either NSAP or cervical radiculopathy and Group 3 will be a control group of non office workers without upper limb pain. Participants will undergo a clinical assessment, pain questionnaires (LANSS, Short Form McGill, DASH and TSK) and quantitative sensory testing comprising thermal detection and pain thresholds, vibration thresholds and pressure pain thresholds. DISCUSSION: The spectrum of clinically suspected neuropathic pain ranges from more obvious conditions such as trigeminal neuralgia to those with vague signs of nerve disorder such as NSAP. A thorough description of the somatosensory profiles of NSAP patients and a comparison with a more defined group of patients with evidence of neuropathic pain will help in the understanding of underlying neurophysiology in NSAP and may influence future classification and intervention studies relating to this condition.

  8. A designated centre for people with disabilities operated by St Michael's House, Dublin 13

    LENUS (Irish Health Repository)

    Presneill, Jeffrey

    2014-01-01

    The Erythropoietin in Traumatic Brain Injury (EPO-TBI) trial aims to determine whether the administration of erythropoietin to patients with moderate or severe traumatic brain injury improves patient-centred outcomes.

  9. A designated centre for people with disabilities operated by St Michael's House, Co. Dublin

    LENUS (Irish Health Repository)

    O'Shea, Donal

    2010-01-01

    BACKGROUND: Obese individuals who smoke have a 14 year reduction in life expectancy. Both obesity and smoking are independently associated with increased risk of malignancy. Natural killer cells (NK) are critical mediators of anti-tumour immunity and are compromised in obese patients and smokers. We examined whether NK cell function was differentially affected by cigarette smoke in obese and lean subjects. METHODOLOGY AND PRINCIPAL FINDINGS: Clinical data and blood were collected from 40 severely obese subjects (BMI>40 kg\\/m(2)) and 20 lean healthy subjects. NK cell levels and function were assessed using flow cytometry and cytotoxicity assays. The effect of cigarette smoke on NK cell ability to kill K562 tumour cells was assessed in the presence or absence of the adipokines leptin and adiponectin. NK cell levels were significantly decreased in obese subjects compared to lean controls (7.6 vs 16.6%, p = 0.0008). NK function was also significantly compromised in obese patients (30% +\\/- 13% vs 42% +\\/-12%, p = 0.04). Cigarette smoke inhibited NK cell ability to kill tumour cell lines (p<0.0001). NK cells from obese subjects were even more susceptible to the inhibitory effects of smoke compared to lean subjects (33% vs 28%, p = 0.01). Cigarette smoke prevented NK cell activation, as well as perforin and interferon-gamma secretion upon tumour challenge. Adiponectin but not leptin partially reversed the effects of smoke on NK cell function in both obese (p = 0.002) and lean controls (p = 0.01). CONCLUSIONS\\/SIGNIFICANCE: Obese subjects have impaired NK cell activity that is more susceptible to the detrimental effects of cigarette smoke compared to lean subjects. This may play a role in the increase of cancer and infection seen in this population. Adiponectin is capable of restoring NK cell activity and may have therapeutic potential for immunity in obese subjects and smokers.

  10. Der "Patriotismus" des Aufklärungszeitalters in den baltischen Provinzen des Russischen Imperiums / Michael Schippan

    Index Scriptorium Estoniae

    Schippan, Michael, 1955-

    2004-01-01

    Patriotismi mõiste käsitlemisest 18. sajandi teise poole saksa ja baltisaksa publitsistikas. 18. sajandi teise poole valgustuslikest ideedest mõjustatud baltisaksa publitsistidest - Johann Gottfried Herderist, Johann Georg Hamannist, Johann Christoph Berensist, Johann Georg Eisenist, Gotthard Friedrich Stenderist ja Jakob Heinrich von Lilienfeldist

  11. Paul P. Mebea, John A. Findlay”, Michael 0. Stern8 and ML Givner“.

    African Journals Online (AJOL)

    interest in steroid chemistry arises from significant rating that these compounds have been accorded in medicine. Commercial research on steroid is focused on finding more potent, long acting synthetic drug analogues, possessing essential pharmacological properties. Our interest in this research arises from the report that ...

  12. Standing in Need of Justification: Michael Apple, R. S. Peters and Jürgen Habermas

    Science.gov (United States)

    Wheeler-Bell, Quentin

    2017-01-01

    Curriculum decisions are increasingly seen as technocratic or bureaucratic problems, rather than democratic issues that must be deliberated over. As such, curriculum decisions are placed in the hands of a small minority of bureaucrats and business elites who assume the only purpose of education is to prepare children for college and/or the labour…

  13. Advanced sampling theory with applications how Michael ‘selected’ Amy

    CERN Document Server

    Singh, Sarjinder

    2003-01-01

    This book is a multi-purpose document. It can be used as a text by teachers, as a reference manual by researchers, and as a practical guide by statisticians. It covers 1165 references from different research journals through almost 1900 citations across 1194 pages, a large number of complete proofs of theorems, important results such as corollaries, and 324 unsolved exercises from several research papers. It includes 159 solved, data-based, real life numerical examples in disciplines such as Agriculture, Demography, Social Science, Applied Economics, Engineering, Medicine, and Survey Sampling. These solved examples are very useful for an understanding of the applications of advanced sampling theory in our daily life and in diverse fields of science. An additional 173 unsolved practical problems are given at the end of the chapters. University and college professors may find these useful when assigning exercises to students. Each exercise gives exposure to several complete research papers for researchers/stude...

  14. Yorùbá Proverbs and Musicality Michael Olutayo Olatunji1 Abstract ...

    African Journals Online (AJOL)

    realms). Music is also used extensively in worship and as therapy for the drudgery of routines or to identify the members of a particular occupation or association. Also, like most ethnic groups in Nigeria, the two media through which the sound of music is performed among the Yorùbá people are the musical instruments and ...

  15. Michael Jarrell: A proposito di Rhizomes (Assonance VII b, 1991-1993

    Directory of Open Access Journals (Sweden)

    Pierre Michel

    2011-07-01

    Full Text Available Through the description of the creative path that led to the production of Rhizomes, the swiss composer highlights different aspects of his own musical creativity. The interview focuses on several aspects of the relationship with the technology and how it has influenced the compositional work and the type of support offered, both on a practical level, both on the conceptual one.

  16. Michael Underwood, MD (1737-1820): physician-accoucheur of London.

    Science.gov (United States)

    Dunn, P M

    2006-03-01

    Underwood was the first physician-accoucheur to be appointed to the Royal College of Physicians in London. The same year, 1784, he published a textbook which did much to establish paediatrics as an emerging discipline in its own right. The book contains several original descriptions of childhood diseases.

  17. Michael Underwood, MD (1737–1820): physician‐accoucheur of London

    Science.gov (United States)

    Dunn, P M

    2006-01-01

    Underwood was the first physician‐accoucheur to be appointed to the Royal College of Physicians in London. The same year, 1784, he published a textbook which did much to establish paediatrics as an emerging discipline in its own right. The book contains several original descriptions of childhood diseases. PMID:16492954

  18. Michael Underwood, MD (1737–1820): physician‐accoucheur of London

    OpenAIRE

    Dunn, P M

    2006-01-01

    Underwood was the first physician‐accoucheur to be appointed to the Royal College of Physicians in London. The same year, 1784, he published a textbook which did much to establish paediatrics as an emerging discipline in its own right. The book contains several original descriptions of childhood diseases.

  19. Denarration in Michael Haneke’s funny FUNNY games GAMES [an audiovisual essay

    NARCIS (Netherlands)

    Kiss, Miklós

    2016-01-01

    In literary fiction, Brian Richardson has discerned a troubling kind of incongruity that he labelled denarration. Denarration is “an intriguing and paradoxical narrative strategy that appears in a number of late modern and postmodern texts” (Richardson 2001, 168). Richardson coins the term for cases

  20. Michael Basse, Entmachtung und Selbstzerstörung des Papsttums (1302–1414)

    OpenAIRE

    Willershausen, Andreas

    2016-01-01

    L’histoire de la papauté au XIVe siècle était considérée par les historiens de l’Église comme un temps de déclin spirituel et moral de l’administration de l’Église médiévale. La « curie romaine » établie à Avignon s’est distinguée en premier lieu par une centralisation et une fiscalisation à l’échelle européenne de l’attribution des ordres majeurs, contre l’opposition des chapitres cathédraux et des couvents. Le clergé curial français, majoritairement de formation juridique, a favorisé en fin...

  1. Chief Editor: Michael H. Schleyer Volume 13, Issue 1 Jan - June 2014

    African Journals Online (AJOL)

    Topics include, but are not limited to: theoretical studies, recovery and restoration processes, legal and institutional frameworks, and ... A typical pattern in a positively buoyant plume is one in which a layer of freshwater spreads over .... and moving polewards (southwards). During these times, the ship drift indicated a weak.

  2. Suur-Euroopa - Euroopa Liidu sõbralik Monroe' doktriin / Michael Emerson

    Index Scriptorium Estoniae

    Emerson, Michael

    2003-01-01

    Brüsselis on läinud käiku uus sõnavara, kuigi väljendid veel erinevad: Suur-Euroopa, lähialade poliitika, naabripoliitika, Suur-Euroopa doktriin. Ettekanne laienenud EL tulevikku arutleval Läänemere foorumil 3. ja 4. oktoobril 2002 Ahvenamaal. Lühendatud

  3. Yorùbá Proverbs and Musicality Michael Olutayo Olatunji1 Abstract ...

    African Journals Online (AJOL)

    a young person – even if comparable to that of an elderly person – his ... elderly person,. The number of his “rags” will not be the same as that which pertains to the elderly man. Here, the use of both clothes and rags is symbolic: while the former .... But should a dog get immersed in its pursuit of game when a signal is.

  4. The democratic warrior : the future for the Bosnian military / Peter C. Alexa, Michael Metzsch

    Index Scriptorium Estoniae

    Alexa, Peter C.

    2003-01-01

    Autorid analüüsivad NATO rahukaitsevägede rolli, tegevust Bosnia ja Hertsegoviinas, võimalusi riigi stabiilsuse tugevdamiseks sõjalise koostöö abil peale NATO vägede lahkumist ning võimalusi sõjaväe demokratiseerimiseks Balti Kaitsekolledžile sarnaneva kolme kohalikku etnilist gruppi ühendava sõjakooli rajamisega

  5. A designated centre for people with disabilities operated by St Michael's House, Dublin 9

    LENUS (Irish Health Repository)

    O'Driscoll, Jeremiah

    2011-06-09

    Abstract Background Ankle joint sprain and the subsequent development of chronic ankle instability (CAI) are commonly encountered by clinicians involved in the treatment and rehabilitation of musculoskeletal injuries. It has recently been advocated that ankle joint post-sprain rehabilitation protocols should incorporate dynamic neuromuscular training to enhance ankle joint sensorimotor capabilities. To date no studies have reported on the effects of dynamic neuromuscular training on ankle joint positioning during landing from a jump, which has been reported as one of the primary injury mechanisms for ankle joint sprain. This case report details the effects of a 6-week dynamic neuromuscular training programme on ankle joint function in an athlete with CAI. Methods The athlete took part in a progressive 6-week dynamic neuromuscular training programme which incorporated postural stability, strengthening, plyometric, and speed\\/agility drills. The outcome measures chosen to assess for interventional efficacy were: 1 Cumberland Ankle Instability Tool (CAIT) scores, 2 Star Excursion Balance Test (SEBT) reach distances, 3 ankle joint plantar flexion during drop landing and drop vertical jumping, and 4 ground reaction forces (GRFs) during walking. Results CAIT and SEBT scores improved following participation in the programme. The angle of ankle joint plantar flexion decreased at the point of initial contact during the drop landing and drop vertical jumping tasks, indicating that the ankle joint was in a less vulnerable position upon landing following participation in the programme. Furthermore, GRFs were reduced whilst walking post-intervention. Conclusions The 6-week dynamic neuromuscular training programme improved parameters of ankle joint sensorimotor control in an athlete with CAI. Further research is now required in a larger cohort of subjects to determine the effects of neuromuscular training on ankle joint injury risk factors.

  6. "Michael Can't Read!" Teachers' Gender Stereotypes and Boys' Reading Self-Concept

    Science.gov (United States)

    Retelsdorf, Jan; Schwartz, Katja; Asbrock, Frank

    2015-01-01

    According to expectancy-value theory, the gender stereotypes of significant others such as parents, peers, or teachers affect students' competence beliefs, values, and achievement-related behavior. Stereotypically, gender beliefs about reading favor girls. The aim of this study was to investigate whether teachers' gender stereotypes in relation to…

  7. A designated centre for people with disabilities operated by St Michael's House, Co. Dublin

    LENUS (Irish Health Repository)

    Day, Mary Rose

    2015-03-02

    Self-neglect is a worldwide and serious public health issue that can have serious adverse outcomes and is more common in older people. Cases can vary in presentation, but typically present as poor self-care, poor care of the environment and service refusal. Community nurses frequently encounter self-neglect cases and health and social care professionals play a key role in the identification, management and prevention of self-neglect. Self-neglect cases can give rise to ethical, personal and professional challenges. The aim of this article is to create a greater understanding of the concept of self-neglect among community nurses.

  8. Leadership in Space: Selected Speeches of NASA Administrator Michael Griffin, May 2005 - October 2008

    Science.gov (United States)

    Griffin, Michael

    2008-01-01

    Speech topics include: Leadership in Space; Space Exploration: Real and Acceptable Reasons; Why Explore Space?; Space Exploration: Filling up the Canvas; Continuing the Voyage: The Spirit of Endeavour; Incorporating Space into Our Economic Sphere of Influence; The Role of Space Exploration in the Global Economy; Partnership in Space Activities; International Space Cooperation; National Strategy and the Civil Space Program; What the Hubble Space Telescope Teaches Us about Ourselves; The Rocket Team; NASA's Direction; Science and NASA; Science Priorities and Program Management; NASA and the Commercial Space Industry; NASA and the Business of Space; American Competitiveness: NASA's Role & Everyone's Responsibility; Space Exploration: A Frontier for American Collaboration; The Next Generation of Engineers; System Engineering and the "Two Cultures" of Engineering; Generalship of Engineering; NASA and Engineering Integrity; The Constellation Architecture; Then and Now: Fifty Years in Space; The Reality of Tomorrow; and Human Space Exploration: The Next 50 Years.

  9. P and СP violation in physics MICHAEL GRONAU It has often been ...

    Indian Academy of Sciences (India)

    90, 131803 (2003). BaBar Collaboration: B Aubert et al, hep-ex/0311032. [8] M Gronau and J L Rosner, Phys. Rev. D65, 013004 (2001); Phys. Rev. D65, 093012. (2002); Phys. Rev. D66, 053003 (2002). M Gronau, Phys. Lett. В557, 198 (2003). [9] R Fleischer, Phys. Lett. В459, 306 (1999). M Gronau and J L Rosner, Phys.

  10. The science of subjective well-being, Michael Eid, Randy J. Larsen

    African Journals Online (AJOL)

    with unpleasant experiences, while life satisfaction theories identify happiness with having a favourable attitude towards life. The remaining three chapters in the section explore the contribution of various disciplines to the SWB field, including sociology and evolutionary psychology. McMahon contributes a chapter on 'The.

  11. Põltsamaa loss / Christian Gottlieb Welté, Stavenhagen Wilhelm Siegfried, Johann Michael Graff

    Index Scriptorium Estoniae

    Welté, Christian Gottlieb, 1748/49-1792

    1996-01-01

    Lk. 58 (17. saj. pärinevad figuraalsed ahjukahlid), värv., lk. 59 (fragment 1815. a. alevi kaardist), värv., lk. 221 (sisevaated 1770. aastatest, rokokoodekoor J. M. Graff, reprod TÜ kunstikabineti kogust), lk. 222 (lossiansambel, G. Chr. Velté õlimaal 18. saj. lõpust), värv., lk. 223 (loss ja kirik, G. Chr. Velté õlimaal 18. saj. lõpust), värv., lk. 224 (ampiirstiilis ahi härrastemaja saalis), värv., lk. 225 (loss ja alev, W. S. Stavenhageni gravüür 1867)

  12. Security and defence cooperation - a step towards a Baltic framework / Michael H Clemmesen

    Index Scriptorium Estoniae

    Clemmesen, Michael H

    1999-01-01

    Baltimaade julgeoleku ja riigikaitsealane koostöö. Balti Pataljon (BALTBAT), Balti Mereväeeskaader (BALTRON), Balti Õhuseiresüsteem (BALTNET), Balti kaitsealase koostöö ning rahvusvahelise abi koordineerimiskeskus (BALTSEA), Balti Kaitsekolledzh. Balti Pataljon. Balti Mereväeeskaader. Balti Õhuseiresüsteem. Balti Kaitsealase Koostöö ning Rahvusvahelise Abi Koordineerimiskeskus. Balti Mereväeeskaader. Balti Kaitsekolledzh

  13. Understanding Summary Statistics and Graphical Techniques to Compare Michael Jordan versus LeBron James

    Science.gov (United States)

    Williams, Immanuel James; Williams, Kelley Kim

    2016-01-01

    Understanding summary statistics and graphical techniques are building blocks to comprehending concepts beyond basic statistics. It's known that motivated students perform better in school. Using examples that students find engaging allows them to understand the concepts at a deeper level.

  14. Law and Popular Culture: Current Legal Issues Volume 7 edited by Michael Freeman

    OpenAIRE

    Bradney, Professor Anthony

    2006-01-01

    As Fiss has put it, academics are in law schools, ‘to study law and teach their students what they happen to discover’ (‘‘Of Law and the River,’ and Nihilism and Academic Freedom’ (1985) 35 Journal of Legal Education 1 at p 26). The idea that all questions about legal phenomena that can be asked should be asked, that nothing should remain unexplored, is slowly being accepted in modern university law schools. Institutions that were once the repositories of ephemeral case-notes and palimpsest t...

  15. Vestlus Eve ja Peeter Linnapiga : ajanihe : Eesti fotograafia / intervjueerinud Michael Freitag

    Index Scriptorium Estoniae

    Linnap, Eve, 1960-

    2011-01-01

    Eesti fotograafid oma viimastest töödest ja näitusest "Piltide mälu" Berliinis ning kunsti mõistmise erinevustest lääne ja idabloki vahel, kuna nõukogude ajal on olnud teistsugune sotsiaalne kontekst - kunst tundus olevat mitmel viisil vaba, kuid tal ei olnud vabadust olla sotsiaalne

  16. High-Tg Thiol-Click Thermoset Networks via the Thiol-Maleimide Michael Addition.

    Science.gov (United States)

    Parker, Shelbi; Reit, Radu; Abitz, Haley; Ellson, Gregory; Yang, Kejia; Lund, Benjamin; Voit, Walter E

    2016-07-01

    Thiol-click reactions lead to polymeric materials with a wide range of interesting mechanical, electrical, and optical properties. However, this reaction mechanism typically results in bulk materials with a low glass transition temperature (Tg ) due to rotational flexibility around the thioether linkages found in networks such as thiol-ene, thiol-epoxy, and thiol-acrylate systems. This report explores the thiol-maleimide reaction utilized for the first time as a solvent-free reaction system to synthesize high-Tg thermosetting networks. Through thermomechanical characterization via dynamic mechanical analysis, the homogeneity and Tg s of thiol-maleimide networks are compared to similarly structured thiol-ene and thiol-epoxy networks. While preliminary data show more heterogeneous networks for thiol-maleimide systems, bulk materials exhibit Tg s 80 °C higher than other thiol-click systems explored herein. Finally, hollow tubes are synthesized using each thiol-click reaction mechanism and employed in low- and high-temperature environments, demonstrating the ability to withstand a compressive radial 100 N deformation at 100 °C wherein other thiol-click systems fail mechanically. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. US Air Force Secretary discusses defense, Russian threats to the Baltics / Michael Mustillo

    Index Scriptorium Estoniae

    Mustillo, Michael

    2016-01-01

    Ameerika Ühendriikide õhuväeministri Deborah Lee Jamesi visiidist Lätti, kus arutati Balti riikide julgeolekut ja kaitsekoostööd Ameerika Ühendriikidega. Õhuväeministri visiidist Lielvarde õhuväebaasi, kus peatuvad Ameerika Ühendriikide õhuväelased

  18. 76 FR 19420 - Michael J. Aruta, M.D.; Decision and Order

    Science.gov (United States)

    2011-04-07

    ... Judge (ALJ) John J. Mulrooney, II, issued the attached recommended decision.\\1\\ The Respondent did not... 459, 463 (2009). See also Dewey C. MacKay, 75 FR 49956, 49977 (2010); Medicine Shoppe-Jonesborough, 73... of Fact, Conclusions of Law, and Decision of the Administrative Law Judge John J. Mulrooney, II...

  19. A designated centre for people with disabilities operated by St Michael's House, Dublin 11

    LENUS (Irish Health Repository)

    2006-01-01

    A Vision for Change details a comprehensive model of mental health service provision for Ireland. It describes a framework for building and fostering positive mental health across the entire community and for providing accessible, community-based, specialist services for people with mental illness.\\r\

  20. Tim Lang and Michael Heasman, Food Wars. The Global Battle for Mouths, Minds and Markets

    Directory of Open Access Journals (Sweden)

    Virginie Amilien

    2005-05-01

    Full Text Available Food wars can be understood as a war declaration against nowadays food-world. This book is full of images for a sustainable world which is opposition with the social and economic unfair society we live in. The authors propose quite concrete solution for a new food policy and draw a new frame for food policy and public health.Core arguments are simple: “Food policy is in crisis, in particular over health.” The unique model of food supply we have followed the last 50 years cannot continue that ...

  1. Review: Reiner Keller & Michael Meuser (Eds.). Körperwissen [Knowledge of the Body

    OpenAIRE

    Lehn, Dirk Vom

    2012-01-01

    Over recent years, the new sociology of knowledge has become increasingly interested in issues and debates about the ways in which the body features in people's actions and experience of the social world—debates that over the past two decades have also arisen within the sociology of the body. The edited collection reviewed here is based on the contributions to a conference jointly organised in 2010 by two sections of the German Sociology Association's (DGS): the section "Sociology of Knowledg...

  2. Physics in magnetic fields from Michael Faraday to Pierre Weiss & his contemporaries

    OpenAIRE

    Loude, Jean-François; Bernard, Dominique

    2013-01-01

    The mechanical action on iron of the first horseshoe electro-magnets (1824) was obvious. They quickly found important applications (telegraphy). Their use to investigate more subtle magnetic, magneto-optical, atomic or nuclear properties of matter began in 1845 with Faraday. Until the 1970s, when superconducting magnets became common, iron-cored electromagnets were normally used to produce steady magnetic fields of high intensity. We will follow the history of a series of fundamental physics ...

  3. Art and Identity : The Soviet Woman in Estonian Art / Michael Schwab

    Index Scriptorium Estoniae

    Schwab, Michael, 1966-

    2010-01-01

    Kumu Kunstimuuseumis 8.04.-26.09.2010 avatud näitusest "Nõukogude naine eesti kunstis", kuraatorid Katrin Kivimaa ja Kädi Talvoja. Ernst Hallopi maalist "Piimatootmine Väimela karjandustehnikumis" (1948) ja Lola Liivati maalist "Laulja ja näitleja Elo Tamuli portree" (1954)

  4. Intertextualität bei Michael Ende, Cornelia Funke und Walter Moers

    Directory of Open Access Journals (Sweden)

    Ajda Gabrič

    2016-12-01

    Full Text Available Im Beitrag werden die intertextuellen Bezüge (Zitate und Anspielungen in drei phantastischen Romanen untersucht. Den Romanen ist gemeinsam, dass sie ältere Texte zitieren oder auf diese anspielen. Diese Bezüge zu anderen literarischen Texten haben in den analysierten Romanen verschiedene Funktionen: Sie können didaktisch eingesetzt werden, zur Charakterisierung der Figuren beitragen und die Handlung bewegen, Komik erzeugen oder die Welt, in der sich die Hauptfigur bewegt, als eine literarische Welt, die vorwiegend aus bekannten Motiven zusammengesetzt ist, präsentieren.

  5. Michael Toolan, Progressione narrativa nel racconto: primi passi in una stilistica dei corpora

    Directory of Open Access Journals (Sweden)

    Federico Pianzola

    2010-06-01

    Full Text Available Using tools derived from corpus linguistics, Toolan proposes some principles and techniques for a stylistic analysis which aims at the detection of textual elements that are responsible for reader's expectations and narrative prospection. A specific attention is given to one of this elements: the use of free indirect discourse. He wants to develop some criteria that allow a selection based only on lexical and sintactical data, in order to apply automated methods of searching to wide text corpora and test his theoretical. Here is the original article.

  6. Transmutation of Matter in Byzantium: The Case of Michael Psellos, the Alchemist

    Science.gov (United States)

    Katsiampoura, Gianna

    2008-01-01

    There is thus nothing paradoxical about the inclusion of alchemy in the ensemble of the physical sciences nor in the preoccupation with it on the part of learned men engaged in scientific study. In the context of the Medieval model, where discourse on the physical world was ambiguous, often unclear, and lacking the support of experimental…

  7. Novel in situ forming, degradable dextran hydrogels by michael addition chemistry: synthesis, rheology, and degradation

    NARCIS (Netherlands)

    Hiemstra, C.; van der Aa, L.J.; Zhong, Zhiyuan; Dijkstra, Pieter J.; Feijen, Jan

    2007-01-01

    Various vinyl sulfone functionalized dextrans (dex-VS) (Mn,dextran = 14K or 31K) with degrees of substitution (DS) ranging from 2 to 22 were conveniently prepared by a one-pot synthesis procedure at room temperature. This procedure involved reaction of a mercaptoalkanoic acid with an excess amount

  8. Further Thoughts on the Writing of Stories: A Response to Michael Gard and Ian Wellard

    Science.gov (United States)

    Gilbourne, David; Jones, Robyn

    2014-01-01

    In his most recent piece (Gilbourne et al., 2011) and in the present article, the author revisits the notion of "caring" in applied sport psychology, offering readers the chance to wonder how a word misplaced or a gesture of casual indifference might cause lasting damage. As in his recent book, "Critical Essays in Sport…

  9. Archaeological investigations on the site of the cistercian nunnery of st. Michael / Mauri Kiudsoo, Irita Kallis

    Index Scriptorium Estoniae

    Kiudsoo, Mauri

    2005-01-01

    2004. aasta suvel Tallinnas Suur-Kloostri 2 kinnistul toimunud kaevamistest. Leidis kinnitust hüpotees, mille kohaselt hävitati kloostri rajamisel mingi varasem asustusvorm. Arheoloogilise stratigraafia analüüsil ja fikseerimisel kasutati Edward C. Harrise koostatud stratigraafia teooria ja metoodika põhimõtteid ja nn. Harrise maatriksit

  10. Just How Safe Is Australia's Multilingual Language Policy? A Response to Michael Clyne.

    Science.gov (United States)

    May, Stephen

    1997-01-01

    Response to an article on multiculturalism and status of community languages in Australia finds three areas in which the author's optimism appears not to be justified: argument that placing economic value on languages automatically works in favor of linguistic minorities; assumption that minority languages all have similar economic value; and…

  11. Who Maintains/Relinquishes Which Language How and Why? A Response to Michael Clyne.

    Science.gov (United States)

    Wei, Li

    1997-01-01

    Response to an article on multiculturalism and the status of community languages in Australia, focusing on issues of language maintenance and shift emerging from the article and adding examples from other countries. Questions addressed include who is responsible for maintaining community languages, which are maintained, how this is done, and why,…

  12. The Misery and the Splendour of Multiculturalism: A Response to Michael Clyne.

    Science.gov (United States)

    Joseph, John E.

    1997-01-01

    A response to an article on multiculturalism and the status of community languages in Australia makes a distinction between multilingualism and multiculturalism, and in public policy, between respecting and embracing diverse cultures. Multiculturalism and public attitudes about freedom of speech are also examined. (MSE)

  13. The Case for Economic Considerations in Language Policy Making: A Response to Michael Clyne.

    Science.gov (United States)

    Saravanan, Vanithamani

    1997-01-01

    A response to an article on multiculturalism and the status of community languages in Australia looks at the situation in Singapore, in which the government created policy supporting development of selected languages, and examines the positive economic consequences of the policy. Effects on educational and manpower policy are also considered. (MSE)

  14. A designated centre for people with disabilities operated by St Michael's House, Dublin 9

    LENUS (Irish Health Repository)

    Sermeus, Walter

    2011-04-18

    Abstract Background Current human resources planning models in nursing are unreliable and ineffective as they consider volumes, but ignore effects on quality in patient care. The project RN4CAST aims innovative forecasting methods by addressing not only volumes, but quality of nursing staff as well as quality of patient care. Methods\\/Design A multi-country, multilevel cross-sectional design is used to obtain important unmeasured factors in forecasting models including how features of hospital work environments impact on nurse recruitment, retention and patient outcomes. In each of the 12 participating European countries, at least 30 general acute hospitals were sampled. Data are gathered via four data sources (nurse, patient and organizational surveys and via routinely collected hospital discharge data). All staff nurses of a random selection of medical and surgical units (at least 2 per hospital) were surveyed. The nurse survey has the purpose to measure the experiences of nurses on their job (e.g. job satisfaction, burnout) as well as to allow the creation of aggregated hospital level measures of staffing and working conditions. The patient survey is organized in a sub-sample of countries and hospitals using a one-day census approach to measure the patient experiences with medical and nursing care. In addition to conducting a patient survey, hospital discharge abstract datasets will be used to calculate additional patient outcomes like in-hospital mortality and failure-to-rescue. Via the organizational survey, information about the organizational profile (e.g. bed size, types of technology available, teaching status) is collected to control the analyses for institutional differences. This information will be linked via common identifiers and the relationships between different aspects of the nursing work environment and patient and nurse outcomes will be studied by using multilevel regression type analyses. These results will be used to simulate the impact of changing different aspects of the nursing work environment on quality of care and satisfaction of the nursing workforce. Discussion RN4CAST is one of the largest nurse workforce studies ever conducted in Europe, will add to accuracy of forecasting models and generate new approaches to more effective management of nursing resources in Europe.

  15. 76 FR 45867 - Michael S. Moore, M.D.; Suspension of Registration

    Science.gov (United States)

    2011-08-01

    ... family home with their two children, ages nine and eleven, as well as a niece, and that his in-laws were... plants, and the equipment needed to grow ] marijuana hydroponically. Id. at 8-9. The evidence also showed... investigation and the hearing itself is an important factor to be considered in determining both whether he has...

  16. A designated centre for people with disabilities operated by St Michael's House - Dublin 5

    LENUS (Irish Health Repository)

    Meehan, Maria

    2012-02-05

    Abstract Background Protein tyrosine phosphatase receptor delta (PTPRD) is a member of a large family of protein tyrosine phosphatases which negatively regulate tyrosine phosphorylation. Neuroblastoma is a major childhood cancer arising from precursor cells of the sympathetic nervous system which is known to acquire deletions and alterations in the expression patterns of PTPRD, indicating a potential tumor suppressor function for this gene. The molecular mechanism, however, by which PTPRD renders a tumor suppressor effect in neuroblastoma is unknown. Results As a molecular mechanism, we demonstrate that PTPRD interacts with aurora kinase A (AURKA), an oncogenic protein that is over-expressed in multiple forms of cancer, including neuroblastoma. Ectopic up-regulation of PTPRD in neuroblastoma dephosphorylates tyrosine residues in AURKA resulting in a destabilization of this protein culminating in interfering with one of AURKA\\'s primary functions in neuroblastoma, the stabilization of MYCN protein, the gene of which is amplified in approximately 25 to 30% of high risk neuroblastoma. Conclusions PTPRD has a tumor suppressor function in neuroblastoma through AURKA dephosphorylation and destabilization and a downstream destabilization of MYCN protein, representing a novel mechanism for the function of PTPRD in neuroblastoma.

  17. On the study of culture and mind: Interview with Prof. Michael Cole

    DEFF Research Database (Denmark)

    Glaveanu, Vlad Petre

    2011-01-01

    Culture and mind represent, in themselves, perhaps the two most complicated phenomena to ever be studied. Their massive complexity has posed, for centuries, great challenges to researchers from a variety of fields. It is therefore all the more difficult to understand the interconnection between...... to understanding human nature and human society. Professor Cole, one of the pioneers of cultural psychology, discusses in this interview the theoretical and methodological difficulties that have shaped his work for several decades, a work accompanied at times by great frustrations but also remarkable rewards...

  18. In the Chronographia, is Michael Psellos’ concern for the army entirely disinterested?

    Directory of Open Access Journals (Sweden)

    Vratimos Antonios

    2012-01-01

    Full Text Available The present article analyzes Psellos’ commentary on the disarray of the Byzantine army in the Chronographia. The topic is examined in relation to the political circumstances of the time, and the author’s own particular situation. It is possible to conclude that much of his commentary on the military in the Chronographia is disingenuous and is influenced by his own position and interests.

  19. A designated centre for people with disabilities operated by St Michael's House, Dublin 5

    LENUS (Irish Health Repository)

    O'Dwyer, David N

    2013-10-01

    Rheumatoid Arthritis (RA) is the most common Connective Tissue Disease (CTD) and represents an increasing burden on global health resources. Interstitial lung disease (ILD) has been recognised as a complication of RA but its potential for mortality and morbidity has arguably been under appreciated for decades. New studies have underscored a significant lifetime risk of ILD development in RA. Contemporary work has identified an increased risk of mortality associated with the Usual Interstitial Pneumonia (UIP) pattern which shares similarity with the most devastating of the interstitial pulmonary diseases, namely Idiopathic Pulmonary Fibrosis (IPF). In this paper, we discuss recent studies highlighting the associated increase in mortality in RA-UIP. We explore associations between radiological and histopathological features of RA-ILD and the prognostic implications of same. We emphasise the need for translational research in this area given the growing burden of RA-ILD. We highlight the importance of the respiratory physician as a key stakeholder in the multidisciplinary management of this disorder. RA-ILD focused research offers the opportunity to identify early asymptomatic disease and define the natural history of this extra articular manifestation. This may provide a unique opportunity to define key regulatory fibrotic events driving progressive disease. We also discuss some of the more challenging and novel aspects of therapy for RA-ILD.

  20. Chief Editor: Michael H. Schleyer Volume 13, Issue 1 Jan - June 2014

    African Journals Online (AJOL)

    Schumann EH (1998) The coastal ocean off southeast Africa ... Abstract — The culture of corals for the aquarium trade has been encouraged as a ... both sexual and asexual culture techniques. ...... Reproductive cycle and energy allocation.