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Sample records for h1 detector recherche

  1. Search for excited leptons at the HERA collider with the H1 detector; Recherche de leptons excites sur le collisionneur HERA avec le detecteur H1

    Energy Technology Data Exchange (ETDEWEB)

    Trinh, T.N

    2008-05-15

    The work presented in this Ph.D. thesis is a search for first generation excited leptons using the full data sample collected by the Hl detector installed on the HERA electron (positron)-proton collider. This study is motivated by theoretical approaches which extend the Standard Model by assuming the existence of lepton compositeness. The whole e{sup -}p and e{sup +}p collisions data collected by Hi from 1994 to 2007 and corresponding to a total integrated luminosity of 475 pb{sup -1} have been used for this analysis. The analysis of 13 different topologies was done, covering all the decay branching ratio of excited electrons (e*) and neutrinos ({nu}*). No evidence of the production of first generation excited leptons was observed. Exclusion limits on e* and {nu}* production cross section and on the coupling constant f/{lambda} as a function of the excited leptons mass are derived within gauge mediated models. The limit obtained extend the excluded region compared to previous excited lepton searches. For the first time at HERA, possible e* production via contact interactions is also studied. The e* production via contact and gauge productions together, including the interference between the two production modes, was considered. (author)

  2. Measurement of the Charm and Beauty Structure Functions using the H1 Vertex Detector at HERA

    CERN Document Server

    Aaron, FD; Alexa, C; Alimujiang, K; Andreev, V; Antunovic, B; Asmone, A; Backovic, S; Baghdasaryan, A; Barrelet, E; Bartel, W; Begzsuren, K; Belousov, A; Bizot, J C; Boudry, V; Bozovic-Jelisavcic, I; Bracinik, J; Brandt, G; Brinkmann, M; Brisson, V; Bruncko, D; Bunyatyan, A; Buschhorn, G; Bystritskaya, L; Campbell, A J; Cantun Avila, K B; Cassol-Brunner, F; Cerny, K; Cerny, V; Chekelian, V; Cholewa, A; Contreras, J G; Coughlan, J A; Cozzika, G; Cvach, J; Dainton, J B; Daum, K; Deak, M; de Boer, Y; Delcourt, B; Del Degan, M; Delvax, J; De Wolf, E A; Diaconu, C; Dodonov, V; Dossanov, A; Dubak, A; Eckerlin, G; Efremenko, V; Egli, S; Eliseev, A; Elsen, E; Falkiewicz, A; Favart, L; Fedotov, A; Felst, R; Feltesse, J; Ferencei, J; Fischer, D -J; Fleischer, M; Fomenko, A; Gabathuler, E; Gayler, J; Ghazaryan, Samvel; Glazov, A; Glushkov, I; Goerlich, L; Gogitidze, N; Gouzevitch, M; Grab, C; Greenshaw, T; Grell, B R; Grindhammer, G; Habib, S; Haidt, D; Helebrant, C; Henderson, R C W; Hennekemper, E; Henschel, H; Herbst, M; Herrera, G; Hildebrandt, M; Hiller, K H; Hoffmann, D; Horisberger, R; Hreus, T; Jacquet, M; Janssen, M E; Janssen, X; Jonsson, L; Jung, Andreas Werner; Jung, H; Kapichine, M; Katzy, J; Kenyon, I R; Kiesling, C; Klein, M; Kleinwort, C; Kluge, T; Knutsson, A; Kogler, R; Kostka, P; Kraemer, M; Krastev, K; Kretzschmar, J; Kropivnitskaya, A; Kruger, K; Kutak, K; Landon, M P J; Lange, W; Lastovicka-Medin, G; Laycock, P; Lebedev, A; Leibenguth, G; Lendermann, V; Levonian, S; Li, G; Lipka, K; Liptaj, A; List, B; List, J; Loktionova, N; Lopez-Fernandez, R; Lubimov, V; Lytkin, L; Makankine, A; Malinovski, E; Marage, P; Marti, Ll; Martyn, H -U; Maxfield, S J; Mehta, A; Meyer, A B; Meyer, H; Meyer, H; Meyer, J; Michels, V; Mikocki, S; Milcewicz-Mika, I; Moreau, F; Morozov, A; Morris, J V; Mozer, Matthias Ulrich; Mudrinic, M; Muller, K; Murin, P; Naumann, Th; Newman, P R; Niebuhr, C; Nikiforov, A; Nowak, G; Nowak, K; Nozicka, M; Olivier, B; Olsson, J E; Osman, S; Ozerov, D; Palichik, V; Panagoulias, I; Pandurovic, M; Papadopoulou, Th; Pascaud, C; Patel, G D; Pejchal, O; Perez, E; Petrukhin, A; Picuric, I; Piec, S; Pitzl, D; Placakyte, R; Pokorny, B; Polifka, R; Povh, B; Preda, T; Radescu, V; Rahmat, A J; Raicevic, N; Raspiareza, A; Ravdandorj, T; Reimer, P; Rizvi, E; Robmann, P; Roland, B; Roosen, R; Rostovtsev, A; Rotaru, M; Ruiz Tabasco, J E; Rurikova, Z; Rusakov, S; Salek, D; Sankey, D P C; Sauter, M; Sauvan, E; Schmitt, S; Schoeffel, L; Schoning, A; Schultz-Coulon, H -C; Sefkow, F; Shaw-West, R N; Shtarkov, L N; Shushkevich, S; Sloan, T; Smiljanic, Ivan; Soloviev, Y; Sopicki, P; South, D; Spaskov, V; Specka, Arnd E; Staykova, Z; Steder, M; Stella, B; Stoicea, G; Straumann, U; Sunar, D; Sykora, T; Tchoulakov, V; Thompson, G; Thompson, P D; Toll, T; Tomasz, F; Tran, T H; Traynor, D; Trinh, T N; Truol, P; Tsakov, I; Tseepeldorj, B; Turnau, J; Urban, K; Valkarova, A; Vallee, C; Van Mechelen, P; Vargas Trevino, A; Vazdik, Y; Vinokurova, S; Volchinski, V; von den Driesch, M; Wegener, D; Wissing, Ch; Wunsch, E; Zacek, J; Zalesak, J; Zhang, Z; Zhokin, A; Zimmermann, T; Zohrabyan, H; Zomer, F; Zus, R

    2010-01-01

    Inclusive charm and beauty cross sections are measured in e-p and e+p neutral current collisions at HERA in the kinematic region of photon virtuality 5H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb^-1. The numbers of charm and beauty events are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are combined with previous data and compared to QCD predictions.

  3. Measurement of the charm and beauty structure functions using the H1 vertex detector at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Aaron, F.D. [National Institute for Physics and Nuclear Engineering (NIPNE), Bucharest (Romania); Bucharest Univ. (Romania). Faculty of Physics; Aldaya Martin, M. [DESY, Hamburg (Germany); Alexa, C. [National Institute for Physics and Nuclear Engineering (NIPNE), Bucharest (RO)] (and others)

    2009-06-15

    Inclusive charm and beauty cross sections are measured in e{sup -}p and e{sup +}p neutral current collisions at HERA in the kinematic region of photon virtuality 5{<=}Q{sup 2}{<=}2000 GeV{sup 2} and Bjorken scaling variable 0.0002{<=}x{<=}0.05. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb{sup -1}. The numbers of charm and beauty events are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are combined with previous data and compared to QCD predictions. (orig.)

  4. Electron deuteron scattering with HERA, a letter of intent for an experimental programme with the H1 detector

    Energy Technology Data Exchange (ETDEWEB)

    T. Alexopoulos; et. al.

    2003-12-01

    This document outlines the case for a program of electron-deuteron scattering measurements at HERA using the H1 detector. The goals of the e D program are to map the partonic structure of the nucleon at large Q2 and low x, to explore the valence quark distributions at the highest x values, to provide a precise measurement of the strong coupling constant and to investigate the parton recombination phenomena revealed in shadowing and their relationship to diffraction. The importance of these measurements for the understanding of the perturbative and non-perturbative aspects of QCD thought to be responsible for nucleon structure is discussed, as is the significance of the measurements for future experimental programs. Some modifications to both the H1 apparatus and the HERA accelerator are necessary to realize this program; these are presented in the document. Mention is also made of questions that will remain unanswered following the completion of the above program and the potential role of HERA and of H1 in investigating these questions is outlined. Physicists and Institutes interested in supporting this project are asked to inform Max Klein (klein@ifh.de) and Tim Greenshaw (green@hep.ph.liv.ac.uk) that they would like to have their names on the Letter of Intent by Wednesday 30th April 2003.

  5. Search for excited leptons in the data of the H1 experiment at the HERA collider; Recherche de leptons excites dans les donnees de l'experience H1 aupres du collisionneur HERA

    Energy Technology Data Exchange (ETDEWEB)

    Delerue, N

    2002-05-01

    Composite models are one of the possible extensions of the Standard Model. One of their implications, at the energy in the reach of present particles accelerators, would be the excitation of leptons. This PhD. thesis describes the search for excited leptons with the H1 detector installed on the electron-proton collider HERA in Hamburg (Germany). The data used were accumulated between 1994 and 2000 and amount to an integrated luminosity of 120 pb{sup -1}. The analysis of 6 different topologies were done and cover all the branching ratios of deexcitation of excited electron and neutrino. The numbers of candidates found during those analysis is in agreement with the Standard Model expectations. This means that no evidence of excited leptons production was found at HERA. This result was translated in the form of exclusion limits on the coupling of excited leptons (f/{lambda}) depending on the mass of the excited lepton. For the first time at HERA we addressed the case were the natural decay width of the excited neutrino is wider than the experimental resolution. For the first time also, a study of the variation of limit depending on the ratio f'/f was carried out. This study lead to the setting of limits independent of this ratio. The limits obtained extend results previously obtained at HEA and also the results of direct searches at LEP. (author)

  6. Measurement of beauty photoproduction near threshold using Di-electron events with the H1 detector at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Aaron, F.D. [National Institute for Physics and Nuclear Engineering (NIPNE), Bucharest (Romania); Bucharest Univ. (Romania). Faculty of Physics; Alexa, C. [National Institute for Physics and Nuclear Engineering (NIPNE), Bucharest (Romania); Andreev, V. [Lebedev Physical Institute, Moscow (RU)] (and others)

    2012-05-15

    The cross section for ep {yields} eb anti bX in photoproduction is measured with the H1 detector at the ep-collider HERA. The decay channel b anti b {yields} eeX' is selected by identifying the semi-electronic decays of the b-quarks. The total production cross section is measured in the kinematic range given by the photon virtuality Q{sup 2} {<=}1 GeV{sup 2}, the inelasticity 0.05{<=} y {<=}0.65 and the pseudorapidity of the b-quarks vertical stroke {eta}(b) vertical stroke, vertical stroke {eta}(anti b) vertical stroke {<=}2. The differential production cross section is measured as a function of the average transverse momentum of the beauty quarks left angle P{sub T}(b) right angle down to the threshold. The results are compared to next-to-leading-order QCD predictions.

  7. Measurement of beauty photoproduction at threshold using di-electron events with the H1 detector at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Sauter, Michel David

    2009-12-15

    The cross section of b anti b photoproduction in ep collisions has been measured with the H1 detector at HERA. Events containing b-quarks were identified through detection of two low momentum electrons in the nal state. Semileptonic decays b anti b{yields}eeX were exploited in the kinematic range of the photon virtuality Q{sup 2}<1 GeV{sup 2}, the inelasticity 0.2

  8. Measurement of K{sup *{+-}}(892) production in deep inelastic ep scattering with the H1 detector at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Sunar, Deniz

    2009-07-15

    A first measurement is presented of K{sup *}(892){sup {+-}} vector mesons, observed through the decay chain K{sup *}(892){sup {+-}} {yields} K{sup 0}{sub S}{pi}{sup {+-}} {yields} {pi}{sup +}{pi}{sup -}{pi}{sup {+-}}; in neutral current deep-inelastic ep scattering. The data were taken at the HERA collider in the years 2005.2007 with centre of mass energy {radical}(s)=319 GeV using the H1 detector and correspond to an integrated luminosity of approximately 302 pb{sup -1}. The measurement of differential cross section was performed in the kinematic range which covers the photon virtuality 51 GeV and pseudorapidity -1.5<{eta}(K{sup *{+-}})<1.5. The results are compared to predictions of leading order Monte Carlo models matched with the parton showers. Persbericht (orig.)

  9. Measurement of D{sup *} meson with two jets in photoproduction with the H1 detector at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Staykova, Zlatka

    2011-02-15

    Photoproduction events containing a charmed meson D{sup *{+-}} and two jets are investigated with the H1 detector using the HERA II data sample. The measurement is based on e{sup +}p collisions during the period of 2006/2007 data taking and uses integrated luminosity of 113.14 pb{sup -1}. The kinematic range of the measurement covers 100 GeV3.5 GeV. One of the jets has to be associated with the D{sup *} meson itself, such that the parent charmed quark can be tagged. The phase space of the measurement is limited within the central rapidity for the D{sup *} meson and the D{sup *}{sub jet}, vertical stroke {eta} vertical stroke <1.5 while the second jet was measured within, -1.5<{eta}<2.9. Single differential cross sections and double differential distributions were measured and compared to Leading Order Monte Carlo (MC) event generators, Pythia and Cascade and with the Next-to-Leading order MC generator MC rate at NLO. (orig.)

  10. Study of charm quark fragmentation into D{sup *} mesons with the H1 detector at HERA II

    Energy Technology Data Exchange (ETDEWEB)

    Liptaj, Andrej

    2008-12-15

    In this work charm quark fragmentation into D{sup *} mesons is investigated in deep-inelastic electron proton collisions. This work is based on data collected in the years 2004 - 2007 by the H1 detector at HERA, corresponding to a total integrated luminosity of 354.1 pb{sup -1}. Three observables denoted z{sub jet},z{sub hem} and z{sub hem}{sup (jet)} are measured, each of them meant to approximate the momentum fraction of the charm quark transferred to the D{sup *} meson. In case of z{sub jet} the quark momentum is estimated as the momentum of the D{sup *} jet, for the two other observables it is approximated by the momentum of an appropriately chosen D{sup *} hemisphere. The visible range is defined by the phase space requirements on the DIS events: Q{sup 2} > 5 GeV{sup 2}, 0.05 < y < 0.6 and by the cuts applied on the reconstructed D{sup *{+-}} particles: 1.5 GeV < p{sub T}(D{sup *}) < 15.0 GeV and vertical stroke {eta}(D{sup *}) vertical stroke < 1.5. An additional constraint E{sub T}(D{sup *}jet) > 3.0 GeV enters the phase space definition in case of z{sub jet} and z{sub hem}{sup (jet)}, where a reconstructed jet containing the D{sup *} meson is required. Within this phase space the normalized single differential cross sections are measured in bins of the three observables. Two Monte Carlo models, RAPGAP and CASCADE, both interfaced with the PYTHIA program for the Lund string fragmentation, are used to make predictions of the respective cross sections for different parametrizations (Peterson and Kartvelishvili) of the charm fragmentation function. The difference in cross sections between data and Monte Carlo model predictions for different values of the fragmentation parameter is quantified by calculating values of {chi}{sup 2} in order to extract optimal parameters for the Peterson and Kartvelishvili parametrization. Using predictions from PYTHIA for e{sup +}e{sup -} annihilation optimal parameters are extracted also from the published BELLE and ALEPH data

  11. Measurement of the proton structure function F{sub L}(x,Q{sup 2}) with the H1 detector at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Piec, Sebastian

    2010-12-15

    A measurement of the inclusive cross section for the deep-inelastic scattering of positrons on protons at low four-momentum transfer squared Q{sup 2} is presented. The measurement is used for the extraction of the longitudinal proton structure function F{sub L}. The analysis is based on data collected by the H1 experiment during special, low energy runs in the year 2007. The direct technique of the F{sub L} determination based on the extraction of the reduced DIS cross sections for three different centre-of-mass energies is used. For the purpose of the analysis a dedicated electron finder has been developed and integrated with the standard H1 reconstruction software H1REC. The algorithm employs information from two independent tracking detectors the Backward Silicon Tracker and the Central Jet Chamber. The performance of the finder is studied. The thesis presents the cross section and the F{sub L} measurements in the range of 2.5 GeV{sup 2}{<=}Q{sup 2}{<=}25 GeV{sup 2}. (orig.)

  12. Measurement of F_2^ccbar and F_2^bbbar at High Q^2 using the H1 Vertex Detector at HERA

    CERN Document Server

    Aktas, A.; Anthonis, T.; Aplin, S.; Asmone, A.; Babaev, A.; Backovic, S.; Bahr, J.; Baghdasaryan, A.; Baranov, P.; Barrelet, E.; Bartel, W.; Baudrand, S.; Baumgartner, S.; Becker, J.; Beckingham, M.; Behnke, O.; Behrendt, O.; Belousov, A.; Berger, Ch.; Berger, N.; Berndt, T.; Bizot, J.C.; Bohme, J.; Boenig, M.-O.; Boudry, V.; Bracinik, J.; Brandt, G.; Brisson, V.; Broker, H.-B.; Brown, D.P.; Bruncko, D.; Busser, F.W.; Bunyatyan, A.; Buschhorn, G.; Bystritskaya, L.; Campbell, A.J.; Caron, S.; Cassol-Brunner, F.; Cerny, K.; Chekelian, V.; Contreras, J.G.; Coppens, Y.R.; Coughlan, J.A.; Cox, B.E.; Cozzika, G.; Cvach, J.; Dainton, J.B.; Dau, W.D.; Daum, K.; Delcourt, B.; Demirchyan, R.; De Roeck, A.; Desch, K.; De Wolf, E.A.; Diaconu, C.; Dingfelder, J.; Dodonov, V.; Dubak, A.; Duprel, C.; Eckerlin, Guenter; Efremenko, V.; Egli, S.; Eichler, R.; Eisele, F.; Ellerbrock, M.; Elsen, E.; Erdmann, W.; Essenov, S.; Faulkner, P.J.W.; Favart, L.; Fedotov, A.; Felst, R.; Ferencei, J.; Finke, L.; Fleischer, M.; Fleischmann, P.; Fleming, Y.H.; Flucke, G.; Flugge, G.; Fomenko, A.; Foresti, I.; Formanek, J.; Franke, G.; Frising, G.; Frisson, T.; Gabathuler, E.; Gabathuler, K.; Garutti, E.; Garvey, J.; Gayler, J.; Gerhards, R.; Gerlich, C.; Ghazaryan, Samvel; Ginzburgskaya, S.; Glazov, A.; Glushkov, I.; Goerlich, L.; Goettlich, M.; Gogitidze, N.; Gorbounov, S.; Goyon, C.; Grab, C.; Grassler, H.; Greenshaw, T.; Gregori, M.; Grindhammer, Guenter; Gwilliam, C.; Haidt, D.; Hajduk, L.; Haller, J.; Hansson, M.; Heinzelmann, G.; Henderson, R.C.W.; Henschel, H.; Henshaw, O.; Herrera, G.; Herynek, I.; Heuer, R.-D.; Hildebrandt, M.; Hiller, K.H.; Hoting, P.; Hoffmann, D.; Horisberger, R.; Hovhannisyan, A.; Ibbotson, M.; Ismail, M.; Jacquet, M.; Janauschek, L.; Janssen, X.; Jemanov, V.; Jonsson, L.; Johnson, D.P.; Jung, H.; Kant, D.; Kapichine, M.; Karlsson, M.; Katzy, J.; Keller, N.; Kenyon, I.R.; Kiesling, Christian M.; Klein, M.; Kleinwort, C.; Klimkovich, T.; Kluge, T.; Knies, G.; Knutsson, A.; Korbel, V.; Kostka, P.; Koutouev, R.; Kropivnitskaya, A.; Kruger, K.; Kuckens, J.; Landon, M.P.J.; Lange, W.; Lastovicka, T.; Laycock, P.; Lebedev, A.; Leiner, B.; Lemrani, R.; Lendermann, V.; Levonian, S.; Lindfeld, L.; Lipka, K.; List, B.; Lobodzinska, E.; Loktionova, N.; Lopez-Fernandez, R.; Lubimov, V.; Lueders, H.; Luke, D.; Lux, T.; Lytkin, L.; Makankine, A.; Malden, N.; Malinovski, E.; Mangano, S.; Marage, P.; Marks, J.; Marshall, R.; Martisikova, M.; Martyn, H.-U.; Maxeld, S.J.; Meer, D.; Mehta, A.; Meier, K.; Meyer, A.B.; Meyer, H.; Meyer, J.; Mikocki, S.; Milcewicz-Mika, I.; Milstead, D.; Mohamed, A.; Moreau, F.; Morozov, A.; Morris, J.V.; Mozer, Matthias Ulrich; Muller, K.; Murin, P.; Nagovizin, V.; Nankov, K.; Naroska, B.; Naumann, J.; Naumann, Th.; Newman, Paul R.; Niebuhr, C.; Nikiforov, A.; Nikitin, D.; Nowak, G.; Nozicka, M.; Oganezov, R.; Olivier, B.; Olsson, J.E.; Ozerov, D.; Pascaud, C.; Patel, G.D.; Peez, M.; Perez, E.; Perez-Astudillo, D.; Perieanu, A.; Petrukhin, A.; Pitzl, D.; Placakyte, R.; Poschl, R.; Portheault, B.; Povh, B.; Prideaux, P.; Raicevic, N.; Reimer, P.; Rimmer, A.; Risler, C.; Rizvi, E.; Robmann, P.; Roland, B.; Roosen, R.; Rostovtsev, A.; Rurikova, Z.; Rusakov, S.; Salvaire, F.; Sankey, D.P.C.; Sauvan, E.; Schatzel, S.; Scheins, J.; Schilling, F.-P.; Schmidt, S.; Schmitt, S.; Schmitz, C.; Schneider, M.; Schoeffel, L.; Schoning, A.; Schroder, V.; Schultz-Coulon, H.-C.; Schwanenberger, C.; Sedlak, K.; Sefkow, F.; Sheviakov, I.; Shtarkov, L.N.; Sirois, Y.; Sloan, T.; Smirnov, P.; Soloviev, Y.; South, D.; Spaskov, V.; Specka, Arnd E.; Stella, B.; Stiewe, J.; Strauch, I.; Straumann, U.; Tchoulakov, V.; Thompson, Graham; Thompson, P.D.; Tomasz, F.; Traynor, D.; Truoel, Peter; Tsipolitis, G.; Tsurin, I.; Turnau, J.; Tzamariudaki, E.; Uraev, A.; Urban, Marcel; Usik, A.; Utkin, D.; Valkar, S.; Valkarova, A.; Vallee, C.; Van Mechelen, P.; Van Remortel, N.; Vargas Trevino, A.; Vazdik, Y.; Veelken, C.; Vest, A.; Vinokurova, S.; Volchinski, V.; Vujicic, B.; Wacker, K.; Wagner, J.; Weber, G.; Weber, R.; Wegener, D.; Werner, C.; Werner, N.; Wessels, M.; Wessling, B.; Wigmore, C.; Winter, G.-G.; Wissing, Ch.; Woehrling, E.-E.; Wolf, R.; Wunsch, E.; Xella, S.; Yan, W.; Yeganov, V.; Zacek, J.; Zalesak, J.; Zhang, Z.; Zhelezov, A.; Zhokin, A.; Zimmermann, J.; Zohrabyan, H.; Zomer, F.

    2004-01-01

    Measurements are presented of inclusive charm and beauty cross sections in e^+p collisions at HERA for values of photon virtuality Q^2 > 150 GeV^2 and of inelasticity 0.1 < y < 0.7. The charm and beauty fractions are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured by the H1 vertex detector. The data are divided into four regions in Q^2 and Bjorken x, and values for the structure functions F_2^{c\\bar{c}} and F_2^{b\\bar{b}} are obtained. The results are found to be compatible with the predictions of perturbative quantum chromodynamics.

  13. Elastic and proton dissociative J/{psi} photoproduction at low W{sub {gamma}p} with the H1 detector at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Huber, Florian

    2013-02-15

    Elastic and proton dissociative photoproduction of J/{psi} mesons is measured with the H1 detector at the HERA electron proton collider in the photon virtuality phase space of Q{sup 2}H1 analyses. Due to an online selection purely based on tracks both leptonic decay channels J/{psi}{yields}ee and J/{psi}{yields}{mu}{mu} are available for the analysis. Elastic ({gamma}p{yields} J/{psi}p) and proton dissociative ({gamma}p{yields} J/{psi}Y) differential {gamma}p cross sections are determined in a simultaneous measurement as function of the squared momentum transfer at the proton vertex t and as function of W{sub {gamma}p} by means of an unfolding procedure, taking not only all bin correlations into account, but also the correlation between the elastic and proton dissociative process. The obtained elastic and proton dissociative differential cross sections are analysed in a simultaneous fit, taking the full statistical covariance matrices and systematic uncertainty sources into account.

  14. Simulation and calibration of the specific energy loss of the central jet chambers of the H1 detector and measurement of the inclusive D{sup *{+-}} meson cross section in photoproduction at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Hennekemper, Eva

    2011-12-15

    In this thesis the photoproduction of D{sup *} mesons in ep collisions at HERA is analysed. D{sup *} mesons are detected in the 'golden' decay channel D{sup *} {yields} K{pi}{pi}{sub s} with the H1 detector. Compared to earlier analyses, the systematic uncertainty is reduced due to two main improvements. Firstly, the simulation of the Fast Track Trigger, which is based on tracks measured within the central jet chambers, allows the trigger efficiency dependence of various kinematic variables to be evaluated. Secondly, the use of specific energy loss provides the possibility to suppress the non-resonant background. In order to use particle identification with the specific energy loss in the analysis, the simulation of the specific energy loss in the central jet chambers of the H1 detector is improved and the necessary correction functions and calibrations have been determined. This improved final H1 detector simulation is used to determine the cross section of photoproduction of D{sup *} mesons in the HERA II data sample, which corresponds to an integrated luminosity of 113 pb{sup -1}. The measurement was performed in the kinematic region of Q{sup 2}<2 GeV for the photon virtuality and photon-proton center of mass energies of 100

  15. Measurement of the D{sup *{+-}} meson production cross section at low and medium Q{sup 2} with the H1 detector at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Dobre, Monica

    2012-11-15

    The inclusive production of D{sup {+-}}(2010) mesons in deep inelastic scattering is studied using data recorded by the H1 experiment in the years 1999 to 2000 and corresponding to an integrated luminosity of 47.66 pb{sup -1}. The measurement covers the region 21.25 GeV and in pseudorapidity to vertical stroke {eta}(D{sup *}) vertical stroke <1.8. Single and double differential cross sections are compared to leading order and next-to-leading order perturbative QCD predictions.

  16. Measurement of F_2^{c\\bar{c}} and F_2^{b\\bar{b}} at Low Q^2 and x using the H1 Vertex Detector at HERA

    CERN Document Server

    Aktas, A.; Anthonis, T.; Aplin, S.; Asmone, A.; Astvatsatourov, A.; Babaev, A.; Backovic, S.; Bahr, J.; Baghdasaryan, A.; Baranov, P.; Barrelet, E.; Bartel, W.; Baudrand, S.; Baumgartner, S.; Becker, J.; Beckingham, M.; Behnke, O.; Behrendt, O.; Belousov, A.; Berger, Ch.; Berger, N.; Bizot, J.C.; Boenig, M.-O.; Boudry, V.; Bracinik, J.; Brandt, G.; Brisson, V.; Brown, D.P.; Bruncko, D.; Busser, F.W.; Bunyatyan, A.; Buschhorn, G.; Bystritskaya, L.; Campbell, A.J.; Caron, S.; Cassol-Brunner, F.; Cerny, K.; Cerny, V.; Chekelian, V.; Contreras, J.G.; Coughlan, J.A.; Cox, B.E.; Cozzika, G.; Cvach, J.; Dainton, J.B.; Dau, W.D.; Daum, K.; de Boer, Y.; Delcourt, B.; De Roeck, A.; Desch, K.; De Wolf, E.A.; Diaconu, C.; Dodonov, V.; Dubak, A.; Eckerlin, Guenter; Efremenko, V.; Egli, S.; Eichler, R.; Eisele, F.; Ellerbrock, M.; Erdmann, W.; Essenov, S.; Falkewicz, A.; Faulkner, P.J.W.; Favart, L.; Fedotov, A.; Felst, R.; Ferencei, J.; Finke, L.; Fleischer, M.; Fleischmann, P.; Fleming, Y.H.; Flucke, G.; Fomenko, A.; Foresti, I.; Franke, G.; Frisson, T.; Gabathuler, E.; Garutti, E.; Gayler, J.; Gerlich, C.; Ghazaryan, Samvel; Ginzburgskaya, S.; Glazov, A.; Glushkov, I.; Goerlich, L.; Goettlich, M.; Gogitidze, N.; Gorbounov, S.; Goyon, C.; Grab, C.; Greenshaw, T.; Gregori, M.; Grell, B.R.; Grindhammer, Guenter; Gwilliam, C.; Haidt, D.; Hajduk, L.; Hansson, M.; Heinzelmann, G.; Henderson, R.C.W.; Henschel, H.; Henshaw, O.; Herrera, G.; Hildebrandt, M.; Hiller, K.H.; Hoffmann, D.; Horisberger, R.; Hovhannisyan, A.; Hreus, T.; Hussain, S.; Ibbotson, M.; Ismail, M.; Jacquet, M.; Janauschek, L.; Janssen, X.; Jemanov, V.; Jonsson, L.; Johnson, D.P.; Jung, Andreas Werner; Jung, H.; Kapichine, M.; Katzy, J.; Keller, N.; Kenyon, I.R.; Kiesling, Christian M.; Klein, M.; Kleinwort, C.; Klimkovich, T.; Kluge, T.; Knies, G.; Knutsson, A.; Korbel, V.; Kostka, P.; Krastev, K.; Kretzschmar, J.; Kropivnitskaya, A.; Kruger, K.; Kuckens, J.; Landon, M.P.J.; Lange, W.; Lastovicka, T.; Lastovicka-Medin, G.; Laycock, P.; Lebedev, A.; Leibenguth, G.; Lendermann, V.; Levonian, S.; Lindfeld, L.; Lipka, K.; Liptaj, A.; List, B.; Lobodzinska, E.; Loktionova, N.; Lopez-Fernandez, R.; Lubimov, V.; Lucaci-Timoce, A.-I.; Lueders, H.; Luke, D.; Lux, T.; Lytkin, L.; Makankine, A.; Malden, N.; Malinovski, E.; Mangano, S.; Marage, P.; Marshall, R.; Martisikova, M.; Martyn, H.-U.; Maxeld, S.J.; Meer, D.; Mehta, A.; Meier, K.; Meyer, A.B.; Meyer, H.; Meyer, J.; Mikocki, S.; Milcewicz-Mika, I.; Milstead, D.; Mladenov, D.; Mohamed, A.; Moreau, F.; Morozov, A.; Morris, J.V.; Mozer, Matthias Ulrich; Muller, K.; Murin, P.; Nankov, K.; Naroska, B.; Naumann, Th.; Newman, Paul R.; Niebuhr, C.; Nikiforov, A.; Nikitin, D.; Nowak, G.; Nozicka, M.; Oganezov, R.; Olivier, B.; Olsson, J.E.; Osman, S.; Ozerov, D.; Palichik, V.; Panagoulias, I.; Papadopoulou, T.; Pascaud, C.; Patel, G.D.; Peez, M.; Perez, E.; Perez-Astudillo, D.; Perieanu, A.; Petrukhin, A.; Pitzl, D.; Placakyte, R.; Portheault, B.; Povh, B.; Prideaux, P.; Raicevic, N.; Reimer, P.; Rimmer, A.; Risler, C.; Rizvi, E.; Robmann, P.; Roland, B.; Roosen, R.; Rostovtsev, A.; Rurikova, Z.; Rusakov, S.; Salvaire, F.; Sankey, D.P.C.; Sauvan, E.; Schatzel, S.; Schilling, F.-P.; Schmidt, S.; Schmitt, S.; Schmitz, C.; Schoeffel, L.; Schoning, A.; Schultz-Coulon, H.-C.; Sedlak, K.; Sefkow, F.; Shaw-West, R.N.; Sheviakov, I.; Shtarkov, L.N.; Sloan, T.; Smirnov, P.; Soloviev, Y.; South, D.; Spaskov, V.; Specka, Arnd E.; Stella, B.; Stiewe, J.; Strauch, I.; Straumann, U.; Tchoulakov, V.; Thompson, Graham; Thompson, P.D.; Tomasz, F.; Traynor, D.; Truoel, Peter; Tsakov, I.; Tsipolitis, G.; Tsurin, I.; Turnau, J.; Tzamariudaki, E.; Urban, Marcel; Usik, A.; Utkin, D.; Valkar, S.; Valkarova, A.; Vallee, C.; Van Mechelen, P.; Vargas Trevino, A.; Vazdik, Y.; Veelken, C.; Vest, A.; Vinokurova, S.; Volchinski, V.; Vujicic, B.; Wacker, K.; Wagner, J.; Weber, G.; Weber, R.; Wegener, D.; Werner, C.; Werner, N.; Wessels, M.; Wessling, B.; Wigmore, C.; Wissing, Ch.; Wolf, R.; Wunsch, E.; Xella, S.; Yan, W.; Yeganov, V.; Zacek, J.; Zalesak, J.; Zhang, Z.; Zhelezov, A.; Zhokin, A.; Zhu, Y.C.; Zimmermann, J.; Zimmermann, T.; Zohrabyan, H.; Zomer, F.

    2006-01-01

    Measurements are presented of inclusive charm and beauty cross sections in e^+p collisions at HERA for values of photon virtuality 12 \\le Q^2 \\le 60 GeV^2 and of the Bjorken scaling variable 0.0002 \\le x \\le 0.005. The fractions of events containing charm and beauty quarks are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured by the H1 vertex detector. Values for the structure functions F_2^{c\\bar{c}} and F_2^{b\\bar{b}} are obtained. This is the first measurement of F_2^{b\\bar{b}} in this kinematic range. The results are found to be compatible with the predictions of perturbative quantum chromodynamics and withprevious measurements of F_2^{c\\bar{c}}.

  17. H-1 Upgrades (4BW/4BN) (H-1 Upgrades)

    Science.gov (United States)

    2015-12-01

    Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-101 H-1 Upgrades (4BW/4BN) (H-1 Upgrades) As of FY 2017 President’s Budget Defense...5 Mission and Description 6 Executive Summary 7 Threshold Breaches 8 Schedule 9 Performance 11 Track to Budget 16 Cost and...Funding 17 Low Rate Initial Production 26 Foreign Military Sales 27 Nuclear Costs 27 Unit Cost 28 Cost Variance 31 Contracts

  18. Search on charginos and neutralinos with the L3 detector at LEP; Recherche de charginos et de neutralinos avec le detecteur L3 au LEP

    Energy Technology Data Exchange (ETDEWEB)

    Chereau, Xavier [Laboratoire d`Annecy-le-vieux de physique des particules, Grenoble-1 Univ., 74 Annecy (France)

    1998-04-30

    This work presents an experimental search for supersymmetric particles, the charginos and the neutralinos, at center of mass energies {radical} 161, 172 and 183 GeV, with the L3 detector at the e{sup +}e{sup -} collider LEP. Assuming R-parity conservation, SUSY events have a large missing energy, carried by the lightest supersymmetric particle (LSP), which allow us to distinguish them from standard events. Then, for all the studied final states and all the energies, we optimized the selections in order to have the best signal-to-noise ratio. No excess of events were observed with respect to the standard model predictions. We set upper limits on the chargino and neutralino production cross sections. In the frame of the constraint MSSM, these results were combined with the results from the L3 slepton analyses to set lower limits on the chargino and neutralino masses: particularly, we exclude a neutralino {chi}{sub 1}{sup 0} bar lighter than 25.9 GeV/c{sup 2} (95% C.L.). This result plays an important role for the interpretation of the dark matter in universe. The search for events with missing energy needs a detector with a good hermeticity. At the end of 1995, a new electromagnetic calorimeter was installed in the L3 experiment. Here we present the improvements of performances and the calibration of this detector composed of 48 bricks made with lead and scintillating fibers (SPACAL) 71 refs., 104 figs., 21 tabs.

  19. The search for charginos and neutralinos with the ATLAS detector at LHC; La recherche des charginos et des neutralinos avec le detecteur Atlas au LHC

    Energy Technology Data Exchange (ETDEWEB)

    Muanza, G.S.

    1996-05-01

    This thesis concerns the prospective study to evidence the supersymmetry with the ATLAS detector at the CERN Large Hadron Collider (LHC) by searching for the disintegration of chargino-neutralino pairs into three leptons. The analysis of this channel is performed through a rapid simulation of the detector used for the signal processing and to process the background (from the standard model and from the MSSM) which may hinder the detection. The results are given for different configurations of LHC: at low energy ({radical}s = 9.3 TeV), at high energy ({radical}s = 14 TeV), at low luminosity (L = 10 sup 3 sup 3 cm sup -2 sup -1), at high luminosity (L = 10 sup 3 sup 4 cm sup -2 sup -1). Finally, we propose an original method allowing the estimation of the gluino mass (an essential parameter of the MSSM) as well as that of all the charginos and neutralinos. This method is of course approximated but it relies on a unique experimental measurement and permits the rebuilding of the whole mass spectrum of the MSSM jauginos to be performed with a worthy precision. The experimental part of this thesis deals with the tests performed on the new photomultipliers (PMTs) HAMAMATSU R5900 which are foreseen for the outfit of the ATLAS tile calorimeter TICAL. The results of these tests show that the PMTs are in conformity with the specifications of the reading of TICAL. (N.T.).

  20. A computation of H1(Γ, H1(Σ))

    DEFF Research Database (Denmark)

    Villemoes, Rasmus

    Let Σ = Σg,1 be a compact surface of genus g at least 3 with one boundary component, Γ its mapping class group and M = H1(Σ, ℤ) the first integral homology of Σ. Using that Γ is generated by the Dehn twists in a collection of 2g+1 simple closed curves (Humphries' generators) and simple relations ...

  1. H1 in RSA galaxies

    Science.gov (United States)

    Richter, OTTO-G.

    1993-01-01

    The original Revised Shapley-Ames (RSA) galaxy sample of almost 1300 galaxies has been augmented with further bright galaxies from the RSA appendix as well as newer galaxy catalogs. A complete and homogeneous, strictly magnitude-limited all-sky sample of 2345 galaxies brighter than 13.4 in apparent blue magnitude was formed. New 21 cm H1 line observations for more than 600 RSA galaxies have been combined with all previously available H1 data from the literature. This new extentise data act allows detailed tests of widely accepted 'standard' reduction and analysis techniques.

  2. Multijet events in DELPHI detector at LEP, application to the search for supersymmetric particles; Evenements multijets a LEP200 dans DELPHI application a la recherche de particules supersymetriques

    Energy Technology Data Exchange (ETDEWEB)

    Poireau, V

    2001-04-01

    A search for multijet events was performed in the DELPHI detector at LEP. These events are predicted by supersymmetry with R-parity violation. An integrated luminosity of 608 pb{sup -1} was collected in the detector, with a centre of mass energy from 189 GeV to 209 GeV. First of all, pair production of neutralinos and charginos was searched for in the data. These events give 6 to 10 jet final states via a R-parity violating {lambda}'' coupling. During the analysis, a discrepancy was observed in the high number of jet region. It was shown that this disagreement comes from an inaccurate modelization of hadronization in the generators. A correction was applied on the simulation to take this systematic effect into account. The analysis showed no presence of signal, which, in the framework of the mSUGRA model, can be translated into the following limits (at 95 % confidence level): M{sub {chi}{sub 1}{sup {approx}{+-}}} > 102,5 GeV/c{sup 2} and M{sub {chi}{sub 1}{sup {approx}0}} > 38 GeV/c{sup 2}. In addition, supersymmetry with R-parity violation, via A' couplings and a squark exchange, predicts a possible production of a t quark together with a light quark. A search for these events was done in the hadronic channel (four jets) and in the semi-leptonic channel (two jets and two leptons). No excess was found in the data with respect to the standard model expectations, which translates into a 95 % confidence level limit on the coupling product: {lambda}'{sub 1jk}{lambda}'{sup *}{sub 13k} < 0,043 (for j, k = [1;2] and for a squark mass of 100 GeV/c{sup 2}). (author)

  3. Phenomenology and research for squarks at LEP200 with the DELPHI detector; Phenomenologie et recherche de squarks a LEP200 avec le detecteur delphi

    Energy Technology Data Exchange (ETDEWEB)

    Gris, Ph. [CEA Saclay, 91 - Gif-sur-Yvette (France). Dept. d`Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l`Instrumentation Associee]|[Paris-6 Univ., 75 (France)

    1998-05-01

    This thesis is devoted to the study of some supersymmetric quarks such as s-top and s-bottom. This investigation field is all the more interesting since the weak mass of these squarks could be explained by the strong Yukawa coupling between top and bottom quarks. The theoretical framework is defined and the insufficiency of the standard model is highlighted. Different models such as MSSM, supergravity models in which supersymmetry is a global symmetry are described. Squark phenomenology at LEP200 is exposed and the most likely disintegration channels for stop and s-bottom quarks are investigated in various models (MSSM, mSUGRA, supergravity models with light gravitino). The experimental tool used in this work, DELPHI detector is presented, the main elements involved in the search for squarks are precisely described. The last part of this thesis is dedicated to the effective search for squarks, the analysis deals with the energies: {radical}s=161, 172 and 183 GeV for which the luminosity values collected by DELPHI are respectively 9.7, 10 and 54 pb{sup -1}. The results are interpreted within the frameworks of different supersymmetric theories 184 refs.

  4. Measurement of the D{sup *{+-}} meson cross section and extraction of the charm contribution, F{sup c}{sub 2}(x, Q{sup 2}), to the proton structure in deep inelastic ep scattering with the H1 detector at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Andreas Werner

    2009-01-15

    Inclusive production of D{sup *} mesons in deep inelastic scattering at HERA is studied using data taken with the H1 detector in the years 2004 to 2007 corresponding to an integrated luminosity of 347 pb{sup -1}. The measurement covers the region 51.5 GeV and vertical stroke {eta}(D{sup *}) vertical stroke < 1.5. The present measurement is based on an eightfold increased statistics compared to the previous H1 publication and provides a significantly reduced systematic error. Single and double-differential cross sections are compared to leading and next-to-leading order perturbative QCD predictions. The charm contribution, F{sup c}{sub 2} (x,Q{sup 2}), to the proton structure in different QCD evolution schemes is derived from the D{sup *} cross sections and compared to next-to-leading order perturbative QCD predictions. This F{sup c}{sub 2} measurement is performed using a factor of 18 more data compared to the previous H1 publication. The present thesis additionally describes a successfully completed hardware project: The commissioning and optimisation of the third level of the H1 Fast Track Trigger (FTT), which was fully operational from 2006 onwards. The FTT is integrated in the first three levels of the H1 trigger system and provides enhanced selectivity for events with charged particles. The third trigger level of the FTT performs a track-based event reconstruction within a latency of about 100 {mu}s. The third trigger level of the FTT is realised by a farm of PowerPC boards. Furthermore, the FTT simulation is now incorporated into the H1 trigger simulation. (orig.)

  5. Recherche | Page 7 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Renforcement du dialogue entre acteurs de la recherche agricole et ... Le Seminario Permanente de Investigacion Agraria (SEPIA) fut créé au Pérou en 1985 afin de stimuler la recherche pluridisciplinaire et la discussion sur les .

  6. H1N1 influenza (Swine flu)

    Science.gov (United States)

    Swine flu; H1N1 type A influenza ... The H1N1 virus is now considered a regular flu virus. It is one of the three viruses included in the regular (seasonal) flu vaccine . You cannot get H1N1 flu virus from ...

  7. Recherche | Page 8 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Améliorer la sécurité alimentaire et la nutrition grâce à la recherche ... 11 oct. 2016 ... éclairer les politiques grâce à la recherche sur l'agriculture et la sécurité alimentaire;; renforcer l'autonomisation des femmes;; augmenter la .

  8. Luminosity measurement in H1; Mesure de la luminosite pour l'experience H1

    Energy Technology Data Exchange (ETDEWEB)

    Frisson, T

    2006-10-15

    At HERA, luminosity is determined on-line and bunch by bunch by measuring the Bremsstrahlung spectrum from e-p collisions. The Hl collaboration has built a completely new luminosity system in order to sustain the harsh running conditions after the fourfold luminosity increase. Namely, the higher synchrotron radiation doses and the increased event pile-up have governed the design of the two major components, a radiation resistant quartz-fibre electro-magnetic calorimeter, and a fast read-out electronic with on-line energy histogram loading at a rate of 500 kHz. The group was in charge of the electronic and the on-line data analysis of the new luminosity system. In this thesis, I present analysis tools and methods to improve the precision of the luminosity measurement. The energy scale and acceptance calculation methods set out in this thesis permit these values to be determined every four minutes, to an accuracy of 0.5 parts per thousand for the energy scale and 2 parts per thousand for the acceptance. From these results, the degree of accuracy obtained on the luminosity measurement is between 6.5 and 9.5 parts per thousand. These results are currently undergoing validation, with the aim of becoming the standard H1 method. I also studied quasi-elastic Compton events to cross-check the luminosity measurement using the 2003- 2004 and 2005 data. Indeed, this process has a well calculable cross section and a clear experimental signature. The leptonic final state consists of a coplanar e-gamma system, both observable in the central H1 detector. (author)

  9. H1N1 update review.

    Science.gov (United States)

    Alenzi, Faris Q

    2010-03-01

    There is worldwide concern on the spreading pandemic wave of the new swine influenza virus (S-OIV). The WHO has placed the pandemic threat alert to level 6. World leaders and scientists importantly stress that regulations and pandemic preparedness may lower the morbidity and mortality. This review describes the background, origin, epidemiology, signs and symptoms, methods of detecting H1N1, the risk of H1N1 pandemic control plans, immunity to H1N1, vaccination against H1N1, hospital management, patient management, and treatment of symptoms. It also describes in considerable detail the responsibilities of health professionals in navigating the complex areas of laboratory diagnosis, patient isolation procedures, and how to minimize and manage any accompanying staff infections, all of which are vital processes to help mitigate and minimize the seriousness of local and national de-novo outbreaks of emerging H1N1 infection.

  10. Molecular dynamics of histone H1

    National Research Council Canada - National Science Library

    Raghuram, Nikhil; Carrero, Gustavo; Thng, John; Hendzel, Michael J

    2009-01-01

    .... In this review, we focus on the wealth of information gathered on the molecular kinetics of histone H1 molecules using novel imaging techniques, such as fluorescence recovery after photobleaching...

  11. Recherche | Page 4 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC on climate change adaptation | CRDI - Centre de recherches ... The relationship among the allocation of water resources, climate variability, and health risks — such as vector-borne disease — both in West Africa and in .

  12. Recherche | Page 3 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Facing the water barrier | CRDI - Centre de recherches pour le ... A world "water crisis" is poised to deliver its most devastating blow to the Middle East and North Africa — with consequences that rival any conflict — unless this .

  13. Recherche | Page 5 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    South Africa | CRDI - Centre de recherches pour le développement ... South Africa has enjoyed considerable growth since the end of apartheid in 1994 , but the benefits are distributed unequally. Many citizens still lack clean water, .

  14. The electronics of the H1 lead/scintillating-fibre calorimeters-H1 SpaCal Group

    Energy Technology Data Exchange (ETDEWEB)

    Appuhn, R.-D. E-mail: cozzika@hep.saclay.cea.fr; Arndt, C.; Barrelet, E.; Barschke, R.; Bassler, U.; Blouzon, F.; Boudry, V.; Brasse, F.; Bruel, Ph.; Bruncko, D.; Buchholz, R.; Cahan, B.; Chechelnitski, S.; Claxton, B.; Cozzika, G.; Cvach, J.; Dagoret-Campagne, S.; Dau, W.D.; Deckers, H.; Deckers, T.; Descamps, F.; Dirkmann, M.; Dowdell, J.; Drancourt, C.; Durant, O.; Efremenko, V.; Eisenhandler, E.; Eliseev, A.N.; Falley, G.; Ferencei, J.; Fleischer, M.; Fominykh, B.; Gadow, K.; Goerlach, U.; Gorbov, L.A.; Gorelov, I.; Grewe, M.; Hajduk, L.; Herynek, I.; Hladky, J.; Huette, M.; Hutter, H.; Janata, M.; Janczur, W.; Janoth, J.; Joensson, L.; Kacl, I.; Kolanoski, H.; Korbel, V.; Krivan, F.; Lacour, D.; Laforge, B.; Lamarche, F.; Landon, M.P.J.; Laporte, J.-F.; Lebollo, H.; Coguie, A. Le; Lehner, F.; Maracek, R.; Matricon, P.; Meier, K.; Meyer, A.; Migliori, A.; Moreau, F.; Mueller, G.; Murin, P.; Nagovizin, V.; Nicholls, T.C.; Ozerov, D.; Passerieux, J.-P.; Perez, E.; Pharabod, J.P.; Poeschl, R.; Renard, Ch.; Rostovtsev, A.; Royon, C.; Rybicki, K.; Schlief, S.; Schmitt, K.; Schuhmacher, A.; Semenov, A.; Shekelyan, V.; Sirois, Y.; Smirnov, P.A.; Solochenko, V.; Spalek, J.; Spielmann, S.; Steiner, H.; Stellberger, A.; Stiewe, J.; Tasevsky, M.; Tchernyshov, V.; Thiele, K.; Tzamariudaki, E.; Valkar, S.; Vallee, C.; Vallereau, A.; VanDenPlas, D.; Villet, G.; Wacker, K.; Walther, A.; Weber, M.; Wegener, D.; Wenk, T.; Zacek, J.; Zhokin, A.; Zini, P.; Zuber, K

    1999-05-01

    The electronic system developed for the SpaCal lead/scintillating-fibre calorimeters of the H1 detector in operation at the HERA ep collider is described in detail and the performance achieved during H1 data taking is presented. The 10 MHz bunch crossing rate of HERA puts severe constraints on the requirements of the electronics. The energy and time readout are performed, respectively, with a 14-bit dynamic range and with a resolution of {approx}0.4 ns. The trigger branch consists of a nanosecond-resolution calorimetric time of flight for background rejection and an electron trigger based on analog 'sliding windows'. The on-line background rejection currently achieved is {approx}10{sup 6}. The electron trigger allows a low-energy trigger threshold to be set at {approx}0.50{+-}0.08 (RMS) GeV with an efficiency {>=}99.9%. The energy and time performance of the readout and trigger electronics is based on a newly developed low noise ({sigma}{sub noise}{approx}0.4 MeV) wideband (f{<=}200 mHz) preamplifier located at the output of the photomultipliers which are used for the fibre light readout in the {approx}1 T magnetic field of H1.

  15. Antiviral Prophylaxis and H1N1

    Centers for Disease Control (CDC) Podcasts

    2011-07-14

    Dr. Richard Pebody, a consultant epidemiologist at the Health Protection Agency in London, UK, discusses the use of antiviral post-exposure prophylaxis and pandemic H1N1.  Created: 7/14/2011 by National Center for Emerging Zoonotic and Infectious Diseases (NCEZID).   Date Released: 7/18/2011.

  16. H1N1 and influenza viruses

    Science.gov (United States)

    Mirdamadi, Kamelia; Einarson, Adrienne

    2011-01-01

    Abstract Question I have been encouraging pregnant women to receive both the H1N1 and influenza vaccines since I became aware of Health Canada’s guidelines. However, some of the women in my practice have heard conflicting information, often from media sources, and they are hesitant to be vaccinated. What is the evidence behind these guidelines, and should I really be convincing these women to be vaccinated? Answer Pregnant women and growing fetuses are considered a population vulnerable to H1N1 and influenza viruses. Health Canada published a report in late 2010 estimating that this population was at increased risk of hospitalization and severe outcomes of H1N1 infection. Recommendations included pregnant women as a priority group to receive the H1N1 vaccine as well as the influenza vaccine. This information should be explained unambiguously to pregnant women, and they should be made aware of the sensationalism of media reports, which are often based on opinion and not evidence. PMID:21918141

  17. Optimization of the ATLAS detector to search for the two-photon decaying Higgs boson at LHC; Optimisation du detecteur ATLAS pour la recherche du boson de Higgs se desintegrant en deux photons au LHC

    Energy Technology Data Exchange (ETDEWEB)

    Tisserand, V. [Paris-11 Univ., 91 - Orsay (France). Lab. de l' Accelerateur Lineaire]|[Universite de Paris Sud, 91 - Orsay (France)

    1997-02-03

    The two photon decay channel is the most clear and promising way to detect a Higgs boson of an intermediate mass between 80 GeV/c{sup 2} and 150 GeV/c{sup 2} at the future large proton collider of CERN (LHC). As the Higgs mass is narrow in this range, the observation of this channel relies on the performance of the electromagnetic calorimeter. A full simulation study has been performed to evaluate the discovery potential of the ATLAS detector. The results of this simulation have been confirmed by beam tests with a prototype. This simulation includes different contributions such as energy resolution sampling term, electronic and pile-up noise, global constant term and angular measurement of the two photon opening angle. The levels of the irreducible background from prompt di-photon production and the reducible background from jets with isolated leading neutrals pions have been estimated, taking into account the rejection capability of the detector. After the computation of the two photon invariant mass resolution, and the evaluation of signal and background rates, the discovery potential of the Higgs boson with the ATLAS detector was calculated. The Higgs can be discovered at five sigma confidence level after less than a year of data taking at LHC with the nominal luminosity of 10{sup 34} cm{sup -2}.s{sup -1} if the Higgs mass is between 100 GeV/c{sup 2} and 150 GeV/c{sup 2}. The Higgs mass window between 80 GeV/c{sup 2} and 150 GeV/c{sup 2} will be covered with an integrated luminosity of 3.10{sup 5} pb{sup -1}. In the case of the Minimal Supersymmetric Model (MSSM) the plane (m{sub A{sup 0}}, tan({beta})) will be fully explored if m{sub A{sup 0}} > 175 GeV/c{sup 2}. (author)

  18. Territoire de recherche

    Directory of Open Access Journals (Sweden)

    Icart Jean-Claude

    2000-11-01

    Full Text Available Les questions d’ordre cognitif que posent les choix européens en matière de politique agricole sont plus que jamais à l’ordre du jour. La crise de l’ESB révèle l’importance du travail de recherche à entreprendre sur les problèmes de qualité des produits, de sécurité sanitaire, de bien-être animal. Avec les notions de développement durable, de valorisation des terroirs, de biodiversité, de coexistence équilibrée entre diverses utilisations du territoire – notions introduites en 1999 par la loi d’orientation agricole –, c’est un champ de réflexion indissociable du précédent qui a été ainsi officiellement ouvert et dont dépendent la définition d’orientations socialement attendues et l’émergence de meilleures réponses aux besoins des marchés.

  19. Recherche | Page 9 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    À titre de directrice du domaine de programme Agriculture et environnement, Dominique Charron veille au bon déroulement d'activités de recherche ayant pour ... Agroforesterie : de la pratique ancestrale à la discipline scientifique ... ... trouve à Nairobi, ont transformé une pratique ancestrale — le mariage de l' arboriculture ...

  20. Recherche | Page 4 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ce livre présente les résultats d'un projet de recherche de trois ans sur l'histoire et la situation de l'agriculture urbaine à La Havane (Cuba). Une équipe ... Participatory Research and Development for Sustainable Agriculture ... Participatory Research and Development for Sustainable Agriculture and Natural Resource ...

  1. Recherche des oscillations de Neutrinos $\

    CERN Document Server

    Gangler, E

    1997-01-01

    Le detecteur nomad, place sur le faisceau de neutrinos wide-band-beam du sps, de contamination en neutrino tau marginale, permet de rechercher des oscillations neutrino muon - tau dans la region de pertinence cosmologique et de distinguer statistiquement les courants charges des neutrinos tau essentiellement par leur mesure cinematique. Une large part du travail de these a donc ete consacree a la reconstruction des evenements dans les chambres a derive, cible instrumentee et cur de l'experience, dont la physique de detection est decrite. Une methode de recherche de traces fut developpee, utilisant certaines informations d'un autre sous-detecteur de nomad, le trd. Pour combler une perte d'efficacite de reconstruction, une methode de recherche de traces courtes s'appuyant sur des vertex deja constitues fut developpee en exploitant les potentialites du filtre de kalman, algorithme iteratif d'ajustement de traces. Ces methodes sont utilisees en production par la collaboration. Cette these porte sur la recherche d...

  2. Search for Higgs Boson in the channel with missing energy with the detector ALEPH at LEP2; Recherche du Boson de Higgs dans le canal a energie manquante avec le detecteur ALEPH a LEP2

    Energy Technology Data Exchange (ETDEWEB)

    Kado, Marumi [Paris-6 Univ., 95 Paris (France)

    1999-04-20

    A search for the Standard Model Higgs boson in the channel e{sup +}e{sup -} {yields} H{nu}{nu}-bar is presented. An event selection method using Neural Network techniques is developed. The analysis is based on a 254 pb{sup -1} data sample taken at center-of-mass energies from {radical} s = 161 up to 189 GeV (from 1996 to 1998), by the ALEPH detector within the LEP2 program at CERN. The experimental systematic defects are studied and the corrections and uncertainties are evaluated. The study of this channel alone results in a mass lower limit of the Standard Model Higgs boson of 85.8 GeV/c{sup 2} with a sensitivity of 89 GeV/c{sup 2} at the 95% CL. Combined with all studied final states, the limit at 95% CL obtained is: m{sub H} > 90.2 GeV/c{sup 2} (observed) and m{sub H} > 95.7 GeV/c{sup 2} (expected). An interpolation of these results within the Minimal Supersymmetric Standard Model is presented along with the combination of all channels, including those originating from the associated production process (e{sup +}e{sup -} {yields} hA), leading to an exclusion at the 95% CL, for any value of tan{beta}{>=} 1, of the h and A neutral Higgs boson masses of: m{sub H} > 80.1 GeV/c{sup 2} (observed) and m{sub A} > 81.7 GeV/c{sup 2} (observed). (author)

  3. Detectors calibration and research of luminescent materials for non baryonic dark matter detection; Calibration de detecteurs et recherche de materiaux luminescents pour la detection de la matiere noire non baryonique

    Energy Technology Data Exchange (ETDEWEB)

    Messous, M.Y.

    1995-03-01

    This work is dedicated to the characterization of luminescent materials in order to build bolometers for the simultaneous detection of heat an light in the search for WIMPs (Weakly Interacting Massive Particles) candidates for non baryonic dark matter. These double bolometers should enable the identification and measurement of recoil ions after collision between a WIMPs and material nucleus. In our search for highly luminescent materials, we have studied the emission spectra, the time response and the spectra response resulting from laser excitation or ionizing particles bombardment of some crystals such as CaF{sub 2}(Eu), CaF{sub 2}, CeF{sub 3}(Ce) and In{sub 2}Si{sub 2}O{sub 7}. These studies were conducted down to liquid Helium temperature (4 K). After showing the good performance of CaF{sub 2}(Eu) scintillator, we have measured the quenching effect resulting from {sup 19}F and Ca ions recoil in CaF{sub 2}(Eu). This was done at the 14 MeV Tandem accelerator of Bruyeres-Le-Chatel with a pulsed neutron beam, simulating the WIMPs. The data obtained allowed the exploitation of the results of the BPRS (Beijing - Rome - Paris - Saclay) experiments carried out at Gran-Sasso. This results showed a gain of up to an order of magnitude in the exclusion graph of axially coupled WIMPs compared to NaI. With the apparatus developed at IPN Lyon (Nuclear Physical Institute of Lyon), we have also measured the ionization induced by Ge ion recoils in Germanium detector, which is one of the most promising crystals for WIMPs detection in the energy range of 2.8 keV-37.8 keV. An ionization efficiency of 24% to 29% was obtained. (author). refs., figs., tabs.

  4. Bourse de recherche 2018 du CRDI | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Agriculture et sécurité alimentaire, Changements climatiques, Initiative de recherche concertée sur l'adaptation en Afrique et en Asie, Emploi et croissance, Alimentation, environnement et santé, Fondements pour l'innovation, Gouvernance et justice, Fonds d'innovation en vaccins pour le bétail, Santé des mères et des ...

  5. Recherche | Page 4 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    28 nov. 2016 ... Le Fonds Cultiver l'avenir de l'Afrique (CultivAf) gère huit projets visant à soutenir l'élaboration et la mise à l'essai de 24 innovations. Il s'agit . ... 29 août 2017 ... La productivité agricole en Afrique centrale et occidentale demeure faible, mais il existe un solide potentiel de recherche pour améliorer la .

  6. H1-antihistamines for chronic spontaneous urticaria.

    Science.gov (United States)

    Sharma, Maulina; Bennett, Cathy; Cohen, Stuart N; Carter, Ben

    2014-11-14

    Background Chronic spontaneous urticaria (CSU) is characterised by the development of crops of red, itchy, raised weals or hives with no identifiable external cause.Objectives To assess the effects of H1-antihistamines for CSU.Search methods We searched the following databases up to June 2014: Cochrane Skin Group Specialised Register, CENTRAL (2014, Issue 5), MEDLINE(from 1946), EMBASE (from 1974) and PsycINFO (from 1806). We searched five trials registers and checked articles for references to relevant randomised controlled trials.Selection criteria We included randomised controlled trials of H1-antihistamines for CSU. Interventions included single therapy or a combination of H1-antihistamines compared with no treatment (placebo) or another active pharmacological compound at any dose.Data collection and analysis We used standard methodological procedures as expected by The Cochrane Collaboration.Our primary outcome measures were proportion of participants with complete suppression of urticaria: 'good or excellent' response,50% or greater improvement in quality of life measures, and adverse events.We present risk ratios (RR) with 95% confidence intervals(CIs). Main results We identified 73 studies (9759 participants); 34 studies provided data for 23 comparisons. The duration of the intervention was up to two weeks (short-term) or longer than two weeks and up to three months (intermediate-term).Cetirizine 10mg once daily in the short term and in the intermediate term led to complete suppression of urticaria by more participants than was seen with placebo (RR 2.72, 95% CI 1.51 to 4.91). For this same outcome, comparison of desloratadine versus placebo in the intermediate term (5 mg) (RR 37.00, 95% CI 2.31 to 593.70) and in the short term (20 mg) (RR 15.97, 95% CI 1.04 to 245.04)favoured desloratadine, but no differences were seen between 5 mg and 10 mg for short-term treatment.Levocetirizine 20 mg per day (short-term) was more effective for complete suppression of

  7. Analysis list: Suv39h1 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Suv39h1 Pluripotent stem cell + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Suv...39h1.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Suv39h1.5.tsv http://dbarchive.bi...osciencedbc.jp/kyushu-u/mm9/target/Suv39h1.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Suv39h

  8. 2009 H1N1 Flu Vaccine Facts

    Science.gov (United States)

    ... turn Javascript on. Feature: Flu 2009 H1N1 Flu Vaccine Facts Past Issues / Fall 2009 Table of Contents ... H1N1 flu vaccine. 1 The 2009 H1N1 flu vaccine is safe and well tested. Clinical trials conducted ...

  9. Screening of allergic components mediated by H(1)R in homoharringtonine injection through H(1)R/CMC-HPLC/MS.

    Science.gov (United States)

    Guo, Ying; Han, Shengli; Cao, Jingjing; Liu, Qi; Zhang, Tao

    2014-12-01

    It has been reported that the histamine H1 receptor (H(1)R) gene is up-regulated in patients with allergic rhinitis and H(1)R expression level strongly correlates with the severity of allergy symptoms. Drugs for therapy should avoid allergy symptoms, especially for patients with over-expressed H(1)R. Therefore, screening of the components which could induce H(1)R activation is urgently needed for drug safety evaluation. Homoharringtonine injection is a preparation for acute nonlymphocytic leukemia, which is approved by China Food and Drug Administration (CFDA) and US Food and Drug Administration. However, severely adverse reactions often occur with intravenous injection of the preparation. In present study, an H(1)R/CMC model was applied for capturing membrane retained components which could induce H(1)R activation. Retention components were enriched and analyzed by H(1)R/CMC-HPLC/MS. Homoharringtonine was recognized, separated and identified in homoharringtonine injection. Ca(2+) flux assay and p-IP3R expression founded that homoharringtonine retained by the H1 R/CMC model increased phosphorylation of IP3R and promoted cytosolic free Ca(2+) elevation in a dose-dependent manner which further verified the activity of homoharringtonine in activating the H1 R. In conclusion, homoharringtonine was screened and identified as a potential allergic factor. This provides an indication that a patient with over-expressed H1 R should be aware of possible allergic reaction when applying homoharringtonine injection. Copyright © 2014 John Wiley & Sons, Ltd.

  10. H1N1: pandemia e perspectiva atual H1N1: overview and perspectives

    Directory of Open Access Journals (Sweden)

    Nancy Bellei

    2011-12-01

    Full Text Available O vírus influenza de origem suína, A/California/04/2009 (H1N1, foi inicialmente detectado no México e determinou a pandemia de influenza de 2009. Em agosto de 2010, a Organização Mundial da Saúde (OMS declarou o início da fase pós-pandêmica. As características dessa última pandemia foram marcadamente diferentes das anteriores. O vírus emergiu de rearranjos genéticos originários em hospedeiro mamífero não humano, demonstrou transmissibilidade interespécies e afetou a população humana de forma diferente dos vírus pandêmicos anteriores (1918, 1957 e 1968 com maior morbidade e mortalidade em crianças e adultos jovens. Atualmente, o vírus apresenta padrão sazonal da mesma forma que o influenza A H3N2 e o influenza B, mantendo, até o momento, o mesmo perfil de patogenicidade, espectro clínico e sensibilidade a antivirais. A cepa foi incluída na vacina sazonal trivalente anual recomendada, principalmente para proteção dos grupos de risco mais vulneráveis a complicações pelas diferentes cepas de influenza.The swine origin influenza virus A/CALIFORNIA/04/2009 (H1N1 was first detected in Mexico and determined the 2009 influenza pandemic. In August 2010, World Health Organization (WHO declared the beginning of the post-pandemic period. This last pandemic was distinctly different from previous ones. The virus emerged from genetic rearrangement in non-human mammalian host. Moreover, its inter-species transmission is fully reported. However, it affected human population differently from previous pandemic viruses (1918, 1957, 1968, with increased morbidity and mortality among children and young adults. Currently, the virus has a seasonal pattern in the same way as influenza A H3N2 and influenza B, maintaining the same pathogenicity profile, clinical spectrum and sensitivity to antiviral agents. The strain was included in the annual trivalent seasonal vaccine formulation, mainly for risk groups, which are more vulnerable to

  11. Search for low energy quasi-vertical muons with an underwater cosmic neutrino detector, environmental study of the detector setting; Recherche de muons quasi verticaux de basse energie a l'aide d'un detecteur de neutrinos cosmiques sous-marin et etude environnementale de son site d'installation

    Energy Technology Data Exchange (ETDEWEB)

    Blondeau, F. [CEA/Saclay, Dept. d' Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l' Instrumentation Associee (DAPNIA), 91 - Gif-sur-Yvette (France)]|[Paris-7 Univ., 75 (France)

    1999-06-01

    The European collaboration named ANTARES aims at operating a large submarine neutrino telescope. Mooring lines make up this detector. Each is about four hundred metres high and equipped with photomultiplier tubes. These tubes record the Cherenkov light emitted by muons resulting from the interaction of neutrinos with matter. It was chosen to install the telescope in the Mediterranean, off the shore of Toulon, by a depth of twenty-three hundred metres. One chapter of this dissertation is devoted to the environment parameters of this site: amount of natural light, fouling of glass elements and water transparency is reviewed. Such a disposal is originally designed to look for possible astronomic neutrino sources emitting neutrinos, thus being complementary with the study of our Universe relying on gamma rays. It is shown in this dissertation that two other current riddles in physics can be investigated by ANTARES, when a specific analysis is taken into account: what is the mass of the neutrinos on the one hand (via the phenomenon called neutrino oscillations), and in the other hand the evidence for a new particle which could participate to the nature of the dark matter in the Universe. This analysis is based upon the detection of nearly vertical muons (zenith angle less than fifteen degrees), with an energy lower than 100 GeV. (author)

  12. Study and testing of the photomultipliers of TILECAL calorimeter of ATLAS detector. Search for stop t-tilde{sub 1} with ATLAS detector; Etude et caracterisation des photomultiplicateurs du calorimetre a tuiles scintillantes d'atlas. Recherche du stop t-tilde{sub 1} avec le detecteur atlas

    Energy Technology Data Exchange (ETDEWEB)

    Hebrard, Ch

    1999-11-04

    The first part of this thesis presents the prospective study on the possibility that we observe an excess of event with four light quark jets, two b quark jets and missing transverse energy in comparison with the predictions of standard model. In the frame of the SUperGRAvity (SUGRA) these events are produced by the Stop decay. The results show that it will be possible to observe an excess of events if Stop mass is less than 600 GeV. The second part of this work turns on the design of the photomultipliers which will be used in ATLAS Tile Calorimeter. A huge work of development and optimisation has been done to make R7877 Hamamatsu photomultiplier fitting all the specifications dictating by the detector. The measurements developed to characterize the photomultipliers are discussed. An special effort has been done to understand and solve the problem of instability of R7877 photomultiplier. In the future, Tile calorimeter will be equipped with 10000 photomultipliers, so a test bench has been developed in order to characterize all these photomultipliers. The performances of this test bench are inspected for each type of measurement (amplification, quantum efficiency, collection efficiency, dark current, linearity and stability). The specifications and technical design of this test bench are summarized in annexes. (author)

  13. Recherche | CRDI - Centre de recherches pour le développement ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Retourner au menu principal. Centre de recherches pour le développement international Gouvernement du Canada Toggle Menu. Main menu. Ce que nous faisons · Financement · Ressources · À propos du CRDI. Languages. English · Français. Formulaire de demande. Recherche. Mobile Nav Footer Links. Carrières ...

  14. Recherche | CRDI - Centre de recherches pour le développement ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Mobile Nav Footer Links. Carrières · Nous joindre · S'abonner · Se désabonner · Droits d'auteur · Politique de libre accès · Politique de confidentialité · Éthique de la recherche · Transparence · Utilisation du site Web · Accueil · Recherche · Google ...

  15. Sensitive and selective magnetoimmunosensing platform for determination of the food allergen Ara h 1

    Energy Technology Data Exchange (ETDEWEB)

    Montiel, V. Ruiz-Valdepeñas, E-mail: victor_lega90@hotmail.com [Departamento de Química Analítica, Facultad de CC. Químicas, Universidad Complutense de Madrid, E-28040 Madrid (Spain); Campuzano, S., E-mail: susanacr@quim.ucm.es [Departamento de Química Analítica, Facultad de CC. Químicas, Universidad Complutense de Madrid, E-28040 Madrid (Spain); Pellicanò, A., E-mail: alessandro.pellicano@unimi.it [Department of Food, Environmental and Nutritional Sciences (DEFENS), University of Milan, Via Celoria 2, 20133 Milan (Italy); Torrente-Rodríguez, R.M., E-mail: rebeca.magnolia@gmail.com [Departamento de Química Analítica, Facultad de CC. Químicas, Universidad Complutense de Madrid, E-28040 Madrid (Spain); Reviejo, A.J., E-mail: reviejo@quim.ucm.es [Departamento de Química Analítica, Facultad de CC. Químicas, Universidad Complutense de Madrid, E-28040 Madrid (Spain); Cosio, M.S., E-mail: stella.cosio@unimi.it [Department of Food, Environmental and Nutritional Sciences (DEFENS), University of Milan, Via Celoria 2, 20133 Milan (Italy); Pingarrón, J.M., E-mail: pingarro@quim.ucm.es [Departamento de Química Analítica, Facultad de CC. Químicas, Universidad Complutense de Madrid, E-28040 Madrid (Spain)

    2015-06-23

    Highlights: • First amperometric magnetoimmunosensor for Ara h 1 determination. • Sensitive and selective detection of Ara h 1 in 2 h. • LOD of 6.3 ng mL{sup −1}. • Determinations in food extracts and saliva. • Potential applicability in food safety and consumer protection. - Abstract: A highly sensitive disposable amperometric immunosensor based on the use of magnetic beads (MBs) is described for determination of Ara h 1, the major peanut allergen, in only 2 h. The approach uses a sandwich configuration involving selective capture and biotinylated detector antibodies and carboxylic acid-modified MBs (HOOC-MBs). The MBs bearing the immunoconjugates are captured by a magnet placed under the surface of a disposable screen-printed carbon electrode (SPCE) and the affinity reactions are monitored amperometrically at −0.20 V (vs a Ag pseudo-reference electrode) in the presence of hydroquinone (HQ) as electron transfer mediator and upon addition of H{sub 2}O{sub 2} as the enzyme substrate. The developed immunosensor exhibits a wide range of linearity between 20.8 and 1000.0 ng mL{sup −1} Ara h 1, a detection limit of 6.3 ng mL{sup −1}, a great selectivity, a good reproducibility with a RSD of 6.3% for six different immunosensors and a useful lifetime of 25 days. The usefulness of the immunosensor was demonstrated by determining Ara h 1 in different matrices (food extracts and saliva). The results correlated properly with those provided by a commercial ELISA method offering a reliable and promising analytical screening tool in the development of user-friendly devices for on-site determination of Ara h 1.

  16. Epidemiological characteristics of Pandemic Influenza A (H1N1 ...

    African Journals Online (AJOL)

    Background: A novel influenza A virus strain (H1N1-2009) spread first in Mexico and the United Stated in late April 2009, leading to the first influenza pandemic of the 21st century. The objective of this study was to determine the epidemiological and virological characteristics of the pandemic influenza A (H1N1-2009) in ...

  17. Reassortant H1N1 influenza virus vaccines protect pigs against pandemic H1N1 influenza virus and H1N2 swine influenza virus challenge.

    Science.gov (United States)

    Yang, Huanliang; Chen, Yan; Shi, Jianzhong; Guo, Jing; Xin, Xiaoguang; Zhang, Jian; Wang, Dayan; Shu, Yuelong; Qiao, Chuanling; Chen, Hualan

    2011-09-28

    Influenza A (H1N1) virus has caused human influenza outbreaks in a worldwide pandemic since April 2009. Pigs have been found to be susceptible to this influenza virus under experimental and natural conditions, raising concern about their potential role in the pandemic spread of the virus. In this study, we generated a high-growth reassortant virus (SC/PR8) that contains the hemagglutinin (HA) and neuraminidase (NA) genes from a novel H1N1 isolate, A/Sichuan/1/2009 (SC/09), and six internal genes from A/Puerto Rico/8/34 (PR8) virus, by genetic reassortment. The immunogenicity and protective efficacy of this reassortant virus were evaluated at different doses in a challenge model using a homologous SC/09 or heterologous A/Swine/Guangdong/1/06(H1N2) virus (GD/06). Two doses of SC/PR8 virus vaccine elicited high-titer serum hemagglutination inhibiting (HI) antibodies specific for the 2009 H1N1 virus and conferred complete protection against challenge with either SC/09 or GD/06 virus, with reduced lung lesions and viral shedding in vaccine-inoculated animals compared with non-vaccinated control animals. These results indicated for the first time that a high-growth SC/PR8 reassortant H1N1 virus exhibits properties that are desirable to be a promising vaccine candidate for use in swine in the event of a pandemic H1N1 influenza. Copyright © 2011 Elsevier B.V. All rights reserved.

  18. Cancer Research UK | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Cancer Research UK. https://www.cancerresearchuk.org/. Initiative de recherche sur la dimension économique de la lutte antitabac. L'Initiative de recherche sur la dimension économique de la lutte antitabac finance la recherche novatrice sur les politiques fiscales qui appuient la lutte antitabac dans les pays à faible revenu ...

  19. Programme de bourses de recherche sur le changement climatique ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au cours de la phase I (projet no 104391) du Programme de bourses de recherche sur le changement climatique en Afrique (ACCFP), 16 bourses dans le domaine des politiques, 13 dans celui de la recherche doctorale, 13 dans celui de la recherche postdoctorale et 3 dans celui de l'enseignement ont été octroyées à 45 ...

  20. Particle detectors

    CERN Multimedia

    CERN. Geneva

    1999-01-01

    Introduction, interaction of radiation with matter measurement of momentum of charged particles, of energy of e/gamma, hadrons, identification of particles. Design of HEP detectors. Principle of operation and performance of tracking sub-detectors, calorimeters and muon system.

  1. Detector Unit

    CERN Multimedia

    1960-01-01

    Original detector unit of the Instituut voor Kernfysisch Onderzoek (IKO) BOL project. This detector unit shows that silicon detectors for nuclear physics particle detection were already developed and in use in the 1960's in Amsterdam. Also the idea of putting 'strips' onto the silicon for high spatial resolution of a particle's impact on the detector were implemented in the BOL project which used 64 of these detector units. The IKO BOL project with its silicon particle detectors was designed, built and operated from 1965 to roughly 1977. Detector Unit of the BOL project: These detectors, notably the ‘checkerboard detector’, were developed during the years 1964-1968 in Amsterdam, The Netherlands, by the Natuurkundig Laboratorium of the N.V. Philips Gloeilampen Fabrieken. This was done in close collaboration with the Instituut voor Kernfysisch Onderzoek (IKO) where the read-out electronics for their use in the BOL Project was developed and produced.

  2. Histamine and H1-antihistamines: celebrating a century of progress.

    Science.gov (United States)

    Simons, F Estelle R; Simons, Keith J

    2011-12-01

    In this review we celebrate a century of progress since the initial description of the physiologic and pathologic roles of histamine and 70 years of progress since the introduction of H(1)-antihistamines for clinical use. We discuss histamine and clinically relevant information about the molecular mechanisms of action of H(1)-antihistamines as inverse agonists (not antagonists or blockers) with immunoregulatory effects. Unlike first (old)-generation H(1)-antihistamines introduced from 1942 to the mid-1980s, most of the second (new)-generation H(1)-antihistamines introduced subsequently have been investigated extensively with regard to clinical pharmacology, efficacy, and safety; moreover, they are relatively free from adverse effects and not causally linked with fatalities after overdose. Important advances include improved nasal and ophthalmic H(1)-antihistamines with rapid onset of action (in minutes) for allergic rhinitis and allergic conjunctivitis treatment, respectively, and effective and safe use of high (up to 4-fold) doses of oral second-generation H(1)-antihistamines for chronic urticaria treatment. New H(1)-antihistamines introduced for clinical use include oral formulations (bilastine and rupatadine), and ophthalmic formulations (alcaftadine and bepotastine). Clinical studies of H(3)-antihistamines with enhanced decongestant effects have been conducted in patients with allergic rhinitis. Additional novel compounds being studied include H(4)-antihistamines with anti-inflammatory effects in allergic rhinitis, atopic dermatitis, and other diseases. Antihistamines have a storied past and a promising future. Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

  3. Infrared detectors

    CERN Document Server

    Rogalski, Antonio

    2010-01-01

    This second edition is fully revised and reorganized, with new chapters concerning third generation and quantum dot detectors, THz detectors, cantilever and antenna coupled detectors, and information on radiometry and IR optics materials. Part IV concerning focal plane arrays is significantly expanded. This book, resembling an encyclopedia of IR detectors, is well illustrated and contains many original references … a really comprehensive book.-F. Sizov, Institute of Semiconductor Physics, National Academy of Sciences, Kiev, Ukraine

  4. Influenza A (H1N1) organising pneumonia.

    Science.gov (United States)

    Torrego, Alfons; Pajares, Virginia; Mola, Anna; Lerma, Enrique; Franquet, Tomás

    2010-04-27

    In November 2009, countries around the world reported confirmed cases of pandemic influenza H1N1, including over 6000 deaths. No peak in activity has been seen. The most common causes of death are pneumonia and acute respiratory distress syndrome. We report a case of a 55-year-old woman who presented with organising pneumonia associated with influenza A (H1N1) infection confirmed by transbronchial lung biopsy. Organising pneumonia should also be considered as a possible complication of influenza A (H1N1) infection, given that these patients can benefit from early diagnosis and appropriate specific management.

  5. H1-antihistamines induce vacuolation in astrocytes through macroautophagy

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Wei-Wei; Yang, Ying; Wang, Zhe; Shen, Zhe; Zhang, Xiang-Nan [Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058 (China); Wang, Guang-Hui [College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123 (China); Chen, Zhong, E-mail: chenzhong@zju.edu.cn [Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058 (China)

    2012-04-15

    H1-antihistamines induce vacuolation in vascular smooth muscle cells, which may contribute to their cardiovascular toxicity. The CNS toxicity of H1-antihistamines may also be related to their non-receptor-mediated activity. The aim of this study was to investigate whether H1-antihistamines induce vacuolation in astrocytes and the mechanism involved. The H1-antihistamines induced large numbers of giant vacuoles in astrocytes. Such vacuoles were marked with both the lysosome marker Lysotracker Red and the alkalescent fluorescence dye monodansylcadaverine, which indicated that these vacuoles were lysosome-like acidic vesicles. Quantitative analysis of monodansylcadaverine fluorescence showed that the effect of H1-antihistamines on vacuolation in astrocytes was dose-dependent, and was alleviated by extracellular acidification, but aggravated by extracellular alkalization. The order of potency to induce vacuolation at high concentrations of H1-antihistamines (diphenhydramine > pyrilamine > astemizole > triprolidine) corresponded to their pKa ranking. Co-treatment with histamine and the histamine receptor-1 agonist trifluoromethyl toluidide did not inhibit the vacuolation. Bafilomycin A1, a vacuolar (V)-ATPase inhibitor, which inhibits intracellular vacuole or vesicle acidification, clearly reversed the vacuolation and intracellular accumulation of diphenhydramine. The macroautophagy inhibitor 3-methyladenine largely reversed the percentage of LC3-positive astrocytes induced by diphenhydramine, while only partly reversing the number of monodansylcadaverine-labeled vesicles. In Atg5{sup −/−} mouse embryonic fibroblasts, which cannot form autophagosomes, the number of vacuoles induced by diphenhydramine was less than that in wild-type cells. These results indicated that H1-antihistamines induce V-ATPase-dependent acidic vacuole formation in astrocytes, and this is partly mediated by macroautophagy. The pKa and alkalescent characteristic of H1-antihistamines may be the

  6. Gaseous Detectors: Charged Particle Detectors - Particle Detectors and Detector Systems

    CERN Document Server

    Hilke, H J

    2011-01-01

    Gaseous Detectors in 'Charged Particle Detectors - Particle Detectors and Detector Systems', part of 'Landolt-Börnstein - Group I Elementary Particles, Nuclei and Atoms: Numerical Data and Functional Relationships in Science and Technology, Volume 21B1: Detectors for Particles and Radiation. Part 1: Principles and Methods'. This document is part of Part 1 'Principles and Methods' of Subvolume B 'Detectors for Particles and Radiation' of Volume 21 'Elementary Particles' of Landolt-Börnstein - Group I 'Elementary Particles, Nuclei and Atoms'. It contains the Subsection '3.1.2 Gaseous Detectors' of Section '3.1 Charged Particle Detectors' of Chapter '3 Particle Detectors and Detector Systems' with the content: 3.1.2 Gaseous Detectors 3.1.2.1 Introduction 3.1.2.2 Basic Processes 3.1.2.2.1 Gas ionization by charged particles 3.1.2.2.1.1 Primary clusters 3.1.2.2.1.2 Cluster size distribution 3.1.2.2.1.3 Total number of ion pairs 3.1.2.2.1.4 Dependence of energy deposit on particle velocity 3.1.2.2.2 Transport of...

  7. H1-antihistamines induce vacuolation in astrocytes through macroautophagy.

    Science.gov (United States)

    Hu, Wei-Wei; Yang, Ying; Wang, Zhe; Shen, Zhe; Zhang, Xiang-Nan; Wang, Guang-Hui; Chen, Zhong

    2012-04-15

    H1-antihistamines induce vacuolation in vascular smooth muscle cells, which may contribute to their cardiovascular toxicity. The CNS toxicity of H1-antihistamines may also be related to their non-receptor-mediated activity. The aim of this study was to investigate whether H1-antihistamines induce vacuolation in astrocytes and the mechanism involved. The H1-antihistamines induced large numbers of giant vacuoles in astrocytes. Such vacuoles were marked with both the lysosome marker Lysotracker Red and the alkalescent fluorescence dye monodansylcadaverine, which indicated that these vacuoles were lysosome-like acidic vesicles. Quantitative analysis of monodansylcadaverine fluorescence showed that the effect of H1-antihistamines on vacuolation in astrocytes was dose-dependent, and was alleviated by extracellular acidification, but aggravated by extracellular alkalization. The order of potency to induce vacuolation at high concentrations of H1-antihistamines (diphenhydramine>pyrilamine>astemizole>triprolidine) corresponded to their pKa ranking. Co-treatment with histamine and the histamine receptor-1 agonist trifluoromethyl toluidide did not inhibit the vacuolation. Bafilomycin A1, a vacuolar (V)-ATPase inhibitor, which inhibits intracellular vacuole or vesicle acidification, clearly reversed the vacuolation and intracellular accumulation of diphenhydramine. The macroautophagy inhibitor 3-methyladenine largely reversed the percentage of LC3-positive astrocytes induced by diphenhydramine, while only partly reversing the number of monodansylcadaverine-labeled vesicles. In Atg5⁻/⁻ mouse embryonic fibroblasts, which cannot form autophagosomes, the number of vacuoles induced by diphenhydramine was less than that in wild-type cells. These results indicated that H1-antihistamines induce V-ATPase-dependent acidic vacuole formation in astrocytes, and this is partly mediated by macroautophagy. The pKa and alkalescent characteristic of H1-antihistamines may be the major

  8. Germline-specific H1 variants: the "sexy" linker histones.

    Science.gov (United States)

    Pérez-Montero, Salvador; Carbonell, Albert; Azorín, Fernando

    2016-03-01

    The eukaryotic genome is packed into chromatin, a nucleoprotein complex mainly formed by the interaction of DNA with the abundant basic histone proteins. The fundamental structural and functional subunit of chromatin is the nucleosome core particle, which is composed by 146 bp of DNA wrapped around an octameric protein complex formed by two copies of each core histone H2A, H2B, H3, and H4. In addition, although not an intrinsic component of the nucleosome core particle, linker histone H1 directly interacts with it in a monomeric form. Histone H1 binds nucleosomes near the exit/entry sites of linker DNA, determines nucleosome repeat length and stabilizes higher-order organization of nucleosomes into the ∼30 nm chromatin fiber. In comparison to core histones, histone H1 is less well conserved through evolution. Furthermore, histone H1 composition in metazoans is generally complex with most species containing multiple variants that play redundant as well as specific functions. In this regard, a characteristic feature is the presence of specific H1 variants that replace somatic H1s in the germline and during early embryogenesis. In this review, we summarize our current knowledge about their structural and functional properties.

  9. Bourse de recherche : Comité consultatif d'éthique de la recherche ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    6 sept. 2017 ... Les principaux enjeux éthiques comprennent la recherche effectuée dans des contextes fragiles et de conflit, la participation des groupes vulnérables, comme les femmes et les adolescentes, aux efforts de mise en place de la recherche. Le CRDI n'approuvera pas de déplacement vers une région qu'il est ...

  10. Formal kinetics of H1N1 epidemic

    Directory of Open Access Journals (Sweden)

    Gurevich Konstantin G

    2009-09-01

    Full Text Available Abstract Background The formal kinetics of the H1N1 epidemic seems to take the form of an exponential curve. There is a good correlation between this theoretical model and epidemiological data on the number of H1N1-infected people. But this formal model leads to paradoxes about the dates when everyone becomes infected: in Mexico this will happen after one year, then in the rest of the world. Further implications of the formal model The general limitations of this formal kinetics model are discussed. More detailed modeling is examined and the implications are examined in the light of currently available data. The evidence indicates that not more than 10% of the population is initially resistant to the H1N1 virus. Conclusion We are probably only at the initial stage of development of the H1N1 epidemic. Increasing the number of H1N1-resistant people in future (e.g. due to vaccination may influence the dynamics of epidemic development. At present, the development of the epidemic depends only on the number of people in the population who are initially resistant to the virus.

  11. Integrability detectors

    Indian Academy of Sciences (India)

    2015-10-29

    Oct 29, 2015 ... Abstract. In this short review, we present some applications and historical facts about the integrability detectors: Painlevé analysis, singularity confinement and algebraic entropy.

  12. H1N1 in dialysis units: Prevention and management

    Directory of Open Access Journals (Sweden)

    Karkar Ayman

    2010-01-01

    Full Text Available Dialysis patients are at increased risk of contracting influenza A H1N1 and deve-loping serious illness. Increasing the awareness of dialysis patients and continuous education and training of medical staff on early recognition and management of influenza A H1N1 can help in saving the life of patients. Antiviral drugs and influenza vaccines are effective in providing ade-quate immunity in dialysis patients with strict implementation of infection control policies and procedures can help in preventing and controlling the dissemination of influenza A H1N1 in dia-lysis units. We report a case of a patient who presented with HINI influenza and developed acute kidney injury during his hospitalization and his course with disease.

  13. H1N1, globalization and the epidemiology of inequality.

    Science.gov (United States)

    Sparke, Matthew; Anguelov, Dimitar

    2012-07-01

    This paper examines the lessons learned from the 2009 H1N1 pandemic in relation to wider work on globalization and the epidemiology of inequality. The media attention and economic resources diverted to the threats posed by H1N1 were significant inequalities themselves when contrasted with weaker responses to more lethal threats posed by other diseases associated with global inequality. However, the multiple inequalities revealed by H1N1 itself in 2009 still provide important insights into the future of global health in the context of market-led globalization. These lessons relate to at least four main forms of inequality: (1) inequalities in blame for the outbreak in the media; (2) inequalities in risk management; (3) inequalities in access to medicines; and (4) inequalities encoded in the actual emergence of new flu viruses. Copyright © 2011 Elsevier Ltd. All rights reserved.

  14. NM23-H1: a Metastasis-Associated Gene

    Directory of Open Access Journals (Sweden)

    Yi-Torng Tee

    2006-06-01

    Full Text Available The protein product of nm23-H1 gene has activity of nucleoside diphosphate (NDP kinase, which catalyzes the phosphorylation of nucleoside diphosphates to the corresponding nucleoside triphosphates. Reductions in nm23 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas. On the contrary, high levels of nm23 gene expression are noted in the advanced stage of thyroid carcinomas and associated with significant reductions in survival for neuroblastoma and osteosarcoma patients. Although expression of nm23/NDP kinase is divergent in various malignant tumors, its reduced expression seems to be related to increased metastatic potential in most carcinoma types. However, it is hypothesized that nm23 may play a tissue-specific role, and that different regulatory mechanisms may act in different tumors. In ovarian carcinoma, nm23-H1/NDP kinase may be correlated with some clinicopathologic characteristics. In cervical cancer, nm23-H1 is probably involved in cervical carcinogenesis and correlated with some aggressive parameters. Overexpression of nm23-H1 protein may indicate poor survival for cervical cancer patients. Other than histidine 118 residue (amino acid sequence 118: histidine concerned with NDP kinase activity of nm23-H1, serine 120 (amino acid sequence 120: serine related activity of histidine-dependent protein phosphotransfer was recently reported to be responsible for its biological suppressive effects. To inhibit metastatic potential, nm23-H1 is also demonstrated to co-immunoprecipitate the kinase suppressor of Ras and phosphorylate it, and therefore reduce activation of the extracellular signal-regulated kinase mitogen-activated protein kinase pathway in response to signaling.

  15. Lower and upper chromatic numbers for BSTSs(2h - 1

    Directory of Open Access Journals (Sweden)

    Marco Buratti

    2001-08-01

    Full Text Available In [Discrete Math. 174, (1997 247-259] an infinite class of STSs(2h - 1 was found with the upper chromatic number not(χ=h. We prove that in this class, for all STSs(2h - 1 with h<10, the lower chromatic number coincides with the upper chromatic number, i.e. χ=not(χ=h and moreover, there exists a infinite sub-class of STSs with χ=not(χ=h for any value of h.

  16. Optical Detectors

    Science.gov (United States)

    Tabbert, Bernd; Goushcha, Alexander

    Optical detectors are applied in all fields of human activities from basic research to commercial applications in communication, automotive, medical imaging, homeland security, and other fields. The processes of light interaction with matter described in other chapters of this handbook form the basis for understanding the optical detectors physics and device properties.

  17. Vapor Detector

    Science.gov (United States)

    Waddell, H. M.; Garrard, G. C.; Houston, D. W.

    1982-01-01

    Detector eliminates need for removing covers to take samples. Detector is canister consisting of screw-in base and clear plastic tube that contains two colors of silica gel. Monoethylhydrazine and nitrogen tetroxide vapors are visually monitored with canister containing color-changing gels.

  18. 20 CFR 655.700 - What statutory provisions govern the employment of H-1B, H-1B1, and E-3 nonimmigrants and how do...

    Science.gov (United States)

    2010-04-01

    ... issued H-1B visas— (i) 195,000 in fiscal year 2001; (ii) 195,000 in fiscal year 2002; (iii) 195,000 in... employment of H-1B, H-1B1, and E-3 nonimmigrants and how do employers apply for H-1B, H-1B1, and E-3 visas... Requirements for Employers Seeking To Employ Nonimmigrants on H-1b Visas in Specialty Occupations and as...

  19. 1918 pandemic H1N1 DNA vaccine protects ferrets against 2007 H1N1 virus infection

    DEFF Research Database (Denmark)

    Bragstad, Karoline; Martel, Cyril Jean-Marie; Aasted, Bent

    Influenza vaccines with the ability to induce immune responses cross-reacting with drifted virus variants would be of great advantage for vaccine development against seasonal and emerging new strains. We demonstrate that gene gun administrated DNA vaccine encoding HA and NA and/or NP and M proteins...... of the H1N1 pandemic virus from 1918 induce protection in ferrets against infection with a H1N1 (A/New Caledonia/20/99(H1N1)) virus which was included in the conventional vaccine for the 2006-2007 season. The viruses are separated by a time interval of 89 years and differ by 21.2% in the HA1 protein....... These results suggest not only a unique ability of the DNA vaccines, but perhaps also natural infection, to induce cross-protective responses against even extremely drifted virus variants....

  20. Influenza A (H1N1) 2009: a pandemic alarm

    Indian Academy of Sciences (India)

    Prakash

    The most recent updates given by WHO confirm a total of 2,67,105 reported cases of .... Diagnosis of the new reassortant virus needs to be updated accordingly. In response to the rise in H1N1 swine flu ..... Biological and epidemiological aspects of influenza virus H5N1 in context of India; Indian J. Exp. Biol. 44 265–278.

  1. Pneumococcal Pneumonia and Pandemic H1N1

    Centers for Disease Control (CDC) Podcasts

    2012-06-06

    Dr. George Nelson, a CDC medical officer, discusses the relationship between pneumococcal pneumonia and Pandemic H1N1.  Created: 6/6/2012 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 6/6/2012.

  2. H1N1 Influenza A hos mennesker og svin

    DEFF Research Database (Denmark)

    Larsen, Lars Erik

    2009-01-01

    Den nye pandemiske influenza A stamme H1N1 er hovedsagelig et nyt virus, som spredes mellem mennesker, men virusset er formodentlig opstået ved blanding af to svineinfluenza-virus og har derfor bibeholdt evnen til at kunne smitte fra mennesker til svin og fra svin til svin. Det er derfor vigtigt...

  3. Influenza A (H1N1) 2009: a pandemic alarm

    Indian Academy of Sciences (India)

    At this critical juncture when the world has not yet recovered from the threat of avian influenza, the virus has returned in the disguise of swine influenza, a lesser known illness common in pigs. It has reached pandemic proportions in a short time span with health personnel still devising ways to identify the novel H1N1 virus ...

  4. Influenza A (H1N1) pneumonia: HRCT findings

    Energy Technology Data Exchange (ETDEWEB)

    Amorim, Viviane Brandao; Rodrigues, Rosana Souza; Barreto, Miriam Menna; Marchiori, Edson, E-mail: edmarchiori@gmail.com [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil); Zanetti, Glaucia [Escola de Medicina de Petropolis, RJ (Brazil); Hochhegger, Bruno [Santa Casa de Misericordia de Porto Alegre, RS (Brazil)

    2013-11-01

    Objective: to describe aspects found on HRCT scans of the chest in patients infected with the influenza A (H1N1) virus. Methods: we retrospectively analyzed the HRCT scans of 71 patients (38 females and 33 males) with H1N1 infection, confirmed through laboratory tests, between July and September of 2009. The HRCT scans were interpreted by two thoracic radiologists independently, and in case of disagreement, the decisions were made by consensus. Results: the most common HRCT findings were ground-glass opacities (85%), consolidation (64%), or a combination of ground-glass opacities and consolidation (58%). Other findings were airspace nodules (25%), bronchial wall thickening (25%), interlobular septal thickening (21%), crazy-paving pattern (15%), perilobular pattern (3%), and air trapping (3%). The findings were frequently bilateral (89%), with a random distribution (68%). Pleural effusion, when observed, was typically minimal. No lymphadenopathy was identified. Conclusions: the most common findings were ground-glass opacities and consolidations, or a combination of both. Involvement was commonly bilateral with no axial or cranio caudal predominance in the distribution. Although the major tomographic findings in H1N1 infection are nonspecific, it is important to recognize such findings in order to include infection with the H1N1 virus in the differential diagnosis of respiratory symptoms. (author)

  5. Narcolepsy and H1N1 Influenza Vaccination

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2013-07-01

    Full Text Available The incidence of narcolepsy between January 2000 and December 2010 in children in western Sweden and its relation to the Pandemrix H1N1 influenza vaccination were assessed by collection of data from hospital and clinic medical records and by parent telephone interviews.

  6. Structural Analysis of the Histamine H1 Receptor.

    Science.gov (United States)

    Shiroishi, Mitsunori; Kobayashi, Takuya

    2017-01-01

    The crystal structure of the human histamine H1 receptor (H1R) has been determined in complex with its inverse agonist doxepin, a first-generation antihistamine. The crystal structure showed that doxepin sits deeply inside the ligand-binding pocket and predominantly interacts with residues highly conserved among other aminergic receptors. This binding mode is considered to result in the low selectivity of the first-generation antihistamines for H1R. The crystal structure also revealed the mechanism of receptor inactivation by the inverse agonist doxepin. On the other hand, the crystal structure elucidated the anion-binding site near the extracellular portion of the receptor. This site consists of residues not conserved among other aminergic receptors, which are specific for H1R. Docking simulation and biochemical experimentation demonstrated that a carboxyl group on the second-generation antihistamines interacts with the anion-binding site. These results imply that the anion-binding site is a key site for the development of highly selective antihistamine drugs.

  7. PTEN Interacts with Histone H1 and Controls Chromatin Condensation

    Science.gov (United States)

    Chen, Zhu Hong; Zhu, Minglu; Yang, Jingyi; Liang, Hui; He, Jinxue; He, Shiming; Wang, Pan; Kang, Xi; McNutt, Michael A.; Yin, Yuxin; Shen, Wen H.

    2014-01-01

    SUMMARY Chromatin organization and dynamics are integral to global gene transcription. Histone modification influences chromatin status and gene expression. PTEN plays multiple roles in tumor suppression, development and metabolism. Here we report on the interplay of PTEN, histone H1 and chromatin. We show that loss of PTEN leads to dissociation of histone H1 from chromatin and decondensation of chromatin. PTEN deletion also results in elevation of histone H4 acetylation at lysine 16, an epigenetic marker for chromatin activation. We found that PTEN and histone H1 physically interact through their C-terminal domains. Disruption of the PTEN C-terminus promotes the chromatin association of MOF acetyltransferase and induces H4K16 acetylation. Hyperacetylation of H4K16 impairs the association of PTEN with histone H1, which constitutes regulatory feedback that may deteriorate chromatin stability. Our results demonstrate that PTEN controls chromatin condensation, thus influencing gene expression. We propose that PTEN regulates global gene transcription profiling through histones and chromatin remodeling. PMID:25199838

  8. Molecular treatment of the ion-pair formation reaction in H(1s) + H(1s) collisions

    Energy Technology Data Exchange (ETDEWEB)

    Borondo, F.; Martin, F.; Yaez, M.

    1987-01-01

    All the available theoretical calculations of the cross section for the ion-pair formation reaction H(1s)+H(1s)..-->..H/sup +/H/sup -/(1s/sup 2/) have been performed using methods that are only valid at high collision energies. They get good agreement with the experiments for impact energies greater than 25 keV, but fail completely at smaller energies. In this work we report the cross section for this reaction at impact energies less than 10 keV, calculated in the framework of the impact-parameter approximation and using the molecular method with a common translation factor.

  9. Initiative des conseils subventionnaires de la recherche scientifique ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    En réponse à ces défis, l'initiative des conseils subventionnaires de la recherche scientifique en Afrique subsaharienne cherche à renforcer les capacités des conseils subventionnaires de la recherche scientifique de façon à appuyer la recherche et l'élaboration de politiques fondées sur des données probantes qui ...

  10. Qu'est-ce qu'une bonne recherche?

    International Development Research Centre (IDRC) Digital Library (Canada)

    Corey Piccioni

    L'évaluation de l'excellence en recherche suscite de plus en plus d'intérêt depuis quelques années. Les gouvernements du Royaume-Uni, de l'Australie et d'autres pays ont en effet entrepris d'exa- miner comment attribuer les fonds de recherche en fonction de la qualité des travaux de recherche produits. Toutefois, on se ...

  11. Bourse de recherche – Emploi et croissance | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    7 sept. 2016 ... Emploi et croissance est à la recherche d'un boursier qui mènera des recherches sur l'un ou plusieurs des axes thématiques du programme. Une attention particulière sera accordée aux projets de recherche qui portent sur l'emploi des jeunes, l'autonomisation économique des femmes, l'entrepreneuriat et ...

  12. Gaseous Detectors

    Science.gov (United States)

    Titov, Maxim

    Since long time, the compelling scientific goals of future high-energy physics experiments were a driving factor in the development of advanced detector technologies. A true innovation in detector instrumentation concepts came in 1968, with the development of a fully parallel readout for a large array of sensing elements - the Multi-Wire Proportional Chamber (MWPC), which earned Georges Charpak a Nobel prize in physics in 1992. Since that time radiation detection and imaging with fast gaseous detectors, capable of economically covering large detection volumes with low mass budget, have been playing an important role in many fields of physics. Advances in photolithography and microprocessing techniques in the chip industry during the past decade triggered a major transition in the field of gas detectors from wire structures to Micro-Pattern Gas Detector (MPGD) concepts, revolutionizing cell-size limitations for many gas detector applications. The high radiation resistance and excellent spatial and time resolution make them an invaluable tool to confront future detector challenges at the next generation of colliders. The design of the new micro-pattern devices appears suitable for industrial production. Novel structures where MPGDs are directly coupled to the CMOS pixel readout represent an exciting field allowing timing and charge measurements as well as precise spatial information in 3D. Originally developed for the high-energy physics, MPGD applications have expanded to nuclear physics, photon detection, astroparticle and neutrino physics, neutron detection, and medical imaging.

  13. Evolutionary genomics of the pandemic 2009 H1N1 influenza viruses (pH1N 1v

    Directory of Open Access Journals (Sweden)

    Song Gang

    2011-05-01

    Full Text Available Abstract Background A new strain of human H1N1 influenza A viruses was broken out in the April 2009 and caused worldwide pandemic emergency. The present study is trying to estimate a temporal reassortment history of 2009 H1N1 viruses by phylogenetic analysis based on a total 394 sequences of H1N1viruses isolated from swine, human and avian. Results Phylogenetic trees of eight gene segments showed that viruses sampled from human formed a well-supported clade, whereas swine and avian lineages were intermixed together. A new divergence swine sublineage containing gene segments of 2009 H1N1 viruses was characterized, which were closely related with swine viruses collected from USA and South Korea during 2004 to 2007 in six segments (PB2, PB1, PA, HA, NP and NS, and to swine viruses isolated from Thailand during 2004 to 2005 in NA and M. Substitution rates were varied drastically among eight segments and the average substitution rate was generally higher in 2009 H1N1 than in swine and human viruses (F2,23 = 5.972, P dN/dS substitution ratios were identified in 2009 H1N1 than in swine and human viruses except M2 gene (F2, 25 = 3.779, P Conclusion Our results implied that at least four reassortments or transmissions probably occurred before 2009 H1N1 viruses. Initial reassortment arose in 1976 and avian-like Eurasian swine viruses emerged. The second transmission happened in Asia and North America between 1988 and 1992, and mostly influenced six segments (PB2, PB1, PA, HA, NP and NS. The third reassortment occurred between North American swine and avian viruses during 1998 to 2000, which involved PB2 and PA segments. Recent reassortments occurred among avian-to-swine reassortant, Eurasian and classical swine viruses during 2004 to 2005. South Korea, Thailand and USA, were identified as locations where reassortments most likely happened. The co-circulation of multiple swine sublineages and special lifestyle in Asia might have facilitated mixing of

  14. Conditions, dynamiques et analyses des partenariats de recherche

    Directory of Open Access Journals (Sweden)

    Anne Gillet

    2011-10-01

    Full Text Available Dans le cadre de ce dossier de la Revue SociologieS, nous proposons une thématique consacrée à la « recherche partenariale », forme de recherche construite entre chercheurs et autres milieux professionnels (entreprises, administrations publiques, associations, syndicat…. Constatant en effet dans certains pays un intérêt pour la recherche partenariale, avec parallèlement un manque flagrant de connaissances et d’analyses théoriques développées sur ce type de recherche, il paraît pertinent de p...

  15. La recherche alpine aujourd’hui

    Directory of Open Access Journals (Sweden)

    Jean-Jacques Brun

    2009-06-01

    Full Text Available Alpine research benefits from several international coordination networks, only one of which – ISCAR (the International Scientific Committee on Research in the Alps – works solely in the Alpine arc. The creation of ISCAR is a consequence of the input and involvement of various Alpine partners around the Alpine Convention. Alpine research now aims to promote an integrated vision of Alpine territories focusing on creating and maintaining spatial and temporal networks of sustainable relationships between humans and the other components of the ecosphere. It combines resource usage with conservation of the biological and cultural diversity that makes up the Alpine identity. This article aims to show: (1 how international Alpine research coordination is organised; (2 the role played by the Alpine Convention as a framework of reference for specifically Alpine research; and (3 the role that the ISCAR international commit-tee and the Interreg “Alpine Space” programmes play in uniting research around territorial challenges relating to biodiversity conservation and territorial development.La recherche sur les Alpes bénéficie de plusieurs réseaux de coordination internationaux dont un seul, le comité international recherche alpine (ISCAR, se consacre exclusivement à l’arc alpin. La création de l’ISCAR est une retombée de la mobilisation des divers partenaires alpins autour de la mise en place de la Convention alpine. Aujourd’hui, la recherche alpine vise à promouvoir une vision intégrée des territoires centrée sur la création et le maintien d’un réseau spatial et temporel de relations durables entre les hommes et les autres composantes de l’écosphère. Elle associe étroitement la mise en valeur des ressources et la conservation des diversités biologiques et culturelles qui constituent l’identité alpine. Cet article a pour ambition de montrer : (1 comment s’organise la coordination internationale des recherches sur les

  16. Spread of H1N1 within Households

    Centers for Disease Control (CDC) Podcasts

    2010-03-29

    This podcast describes an investigation into how H1N1 was spreading within households during the initial days of the pandemic in Texas. CDC's Dr. Oliver Morgan discusses what investigators learned about the role that children played in introducing the virus into households and spreading flu.  Created: 3/29/2010 by Emerging Infectious Diseases.   Date Released: 3/29/2010.

  17. Myastenia gravis following H1N1 infection

    OpenAIRE

    Silva, Horta e; Nascimento, A.; Zwolinski, N.; André, A.

    2016-01-01

    Introduction: Myasthenia gravis is an auto-immune disease, resulting from the production of anti-Ach receptor antibodies at the neuromuscular junction. In spite of its unknown etiology, there seems to exist some factors which withstand its arise and/or the worsening of the patient's clinical condition.The mainstay of medical treatment relies on anticholinesterase drugs and immunosuppression. Thymectomy is considered the treatment of choice in selected cases.Influenza A (H1N1) viral infection ...

  18. Alterations of Histone H1 Phosphorylation During Bladder Carcinogenesis

    Science.gov (United States)

    Telu, Kelly H.; Abbaoui, Besma; Thomas-Ahner, Jennifer M.; Zynger, Debra L.; Clinton, Steven K.

    2013-01-01

    There is a crucial need for development of prognostic and predictive biomarkers in human bladder carcinogenesis in order to personalize preventive and therapeutic strategies and improve outcomes. Epigenetic alterations, such as histone modifications, are implicated in the genetic dysregulation that is fundamental to carcinogenesis. Here we focus on profiling the histone modifications during the progression of bladder cancer. Histones were extracted from normal human bladder epithelial cells, an immortalized human bladder epithelial cell line (hTERT), and four human bladder cancer cell lines (RT4, J82, T24, and UMUC3) ranging from superficial low-grade to invasive high-grade cancers. Liquid Chromatography-Mass Spectrometry (LC-MS) profiling revealed a statistically significant increase in phosphorylation of H1 linker histones from normal human bladder epithelial cells to low-grade superficial to high-grade invasive bladder cancer cells. This finding was further validated by immunohistochemical staining of the normal epithelium and transitional cell cancer from human bladders. Cell cycle analysis of histone H1 phosphorylation by western blotting showed an increase of phosphorylation from G0/G1 phase to M phase, again supporting this as a proliferative marker. Changes in histone H1 phosphorylation status may further clarify epigenetic changes during bladder carcinogenesis and provide diagnostic and prognostic biomarkers or targets for future therapeutic interventions. PMID:23675690

  19. DUMAND detector

    CERN Multimedia

    This object is one of the 256 other detectors of the DUMAND (Deep Underwater Muon And Neutrino Detection) experiment. The goal of the experiment was the construction of the first deep ocean high energy neutrino detector, to be placed at 4800 m depth in the Pacific Ocean off Keahole Point on the Big Island of Hawaii. A few years ago, a European conference with Cosmic experiments was organized at CERN as they were projects like DUMAND in Hawaii. Along with the conference, a temporary exhibition was organised as well. It was a collaboration of institutions from Germany, Japan, Switzerland and the U.S.A. CERN had borrowed equipment and objects from different institutes around the world, including this detector of the DUMAND experiment. Most of the equipment were sent back to the institutes, however this detector sphere was offered to a CERN member of the personnel.

  20. MS Detectors

    Energy Technology Data Exchange (ETDEWEB)

    Koppenaal, David W.; Barinaga, Charles J.; Denton, M Bonner B.; Sperline, Roger P.; Hieftje, Gary M.; Schilling, G. D.; Andrade, Francisco J.; Barnes IV., James H.

    2005-11-01

    Good eyesight is often taken for granted, a situation that everyone appreciates once vision begins to fade with age. New eyeglasses or contact lenses are traditional ways to improve vision, but recent new technology, i.e. LASIK laser eye surgery, provides a new and exciting means for marked vision restoration and improvement. In mass spectrometry, detectors are the 'eyes' of the MS instrument. These 'eyes' have also been taken for granted. New detectors and new technologies are likewise needed to correct, improve, and extend ion detection and hence, our 'chemical vision'. The purpose of this report is to review and assess current MS detector technology and to provide a glimpse towards future detector technologies. It is hoped that the report will also serve to motivate interest, prompt ideas, and inspire new visions for ion detection research.

  1. Emission detectors

    CERN Document Server

    Bolozdynya, Alexander I

    2010-01-01

    After decades of research and development, emission detectors have recently become the most successful instrumentation used in modern fundamental experiments searching for cold dark matter, and are also considered for neutrino coherent scattering and magnetic momentum neutrino measurement. This book is the first monograph exclusively dedicated to emission detectors. Properties of two-phase working media based on noble gases, saturated hydrocarbon, ion crystals and semiconductors are reviewed.

  2. Detectors course

    CERN Multimedia

    CERN. Geneva HR-RFA

    2006-01-01

    This lecture series on detectors, will give a general, although somewhat compressed, introduction to particle interaction with matter and magnetic fields. Tracking detectors and calorimeters will also be covered as well as particle identification systems. The lectures will start out with a short review of particle interaction with fields and then we will discuss particle detection. At the end some common composite detection systems will be described.

  3. Calibration of the VIRGO experiment: from the testing of the detector to the search of coalescing binaries with the central interferometer; Calibration de l'experience VIRGO: de l'etalonnage du detecteur a la recherche de signaux de coalescences binaires avec l'interferometre central

    Energy Technology Data Exchange (ETDEWEB)

    Veziant, O

    2003-05-01

    The aim of the VIRGO experiment is the detection of gravitational waves. The detector is based on a Michelson interferometer with three-kilometer long arms. Before the availability of the complete detector, most of the technical choices have been tested on a small scale interferometer (central interferometer or CITF). This allowed to record the first technical data of the experiment. The calibration of the CITF data has been studied in this thesis. This work involved some local operations such as the calibration of the electronics of the detection system, and also some more global operation such as the characterisation of the detector response function. The latter is used to unfold the data from experimental effects and to estimate the detector sensitivity. A monitoring procedure of this response function has been applied to produce a time series of reconstructed data, i.e. data free from experimental distortions. The implementation of VIRGO will make use of an optical calibrator using the radiation pressure of a laser beam to act on the interferometer mirrors and characterize its response. The optical calibrator has been designed and assembled in laboratory and its performances have been measured. The physics analysis following the calibration step was tackled through a coalescing binary search algorithm. The latter was applied both on simulated data and on CITF data in order to estimate the detector noise level and to check the effects of the reconstruction procedure. (author)

  4. Transparence | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Abonnez-vous à notre bulletin électronique dès maintenant pour recevoir des nouvelles et des articles d'opinion du CRDI chaque mois. Abonnez-vous · Droits d'auteur · Éthique de la recherche · Politique de libre accès · Politique de confidentialité · Transparence · Utilisation du site Web. Suivez-nous; Facebook · Twitter ...

  5. The Genomic Landscape of the Somatic Linker Histone Subtypes H1.1 to H1.5 in Human Cells

    Directory of Open Access Journals (Sweden)

    Annalisa Izzo

    2013-06-01

    Full Text Available Human cells contain five canonical, replication-dependent somatic histone H1 subtypes (H1.1, H1.2, H1.3, H1.4, and H1.5. Although they are key chromatin components, the genomic distribution of the H1 subtypes is still unknown, and their role in chromatin processes has thus far remained elusive. Here, we map the genomic localization of all somatic replication-dependent H1 subtypes in human lung fibroblasts using an integrative DNA adenine methyltransferase identification (DamID analysis. We find in general that H1.2 to H1.5 are depleted from CpG-dense regions and active regulatory regions. H1.1 shows a DamID binding profile distinct from the other subtypes, suggesting a unique function. H1 subtypes can mark specific domains and repressive regions, pointing toward a role for H1 in three-dimensional genome organization. Our work integrates H1 subtypes into the epigenome maps of human cells and provides a valuable resource to refine our understanding of the significance of H1 and its heterogeneity in the control of genome function.

  6. Post-translational modifications of linker histone H1 variants in mammals

    Science.gov (United States)

    Starkova, T. Yu; Polyanichko, A. M.; Artamonova, T. O.; Khodorkovskii, M. A.; Kostyleva, E. I.; Chikhirzhina, E. V.; Tomilin, A. N.

    2017-02-01

    The covalent modifications of the linker histone H1 and the core histones are thought to play an important role in the control of chromatin functioning. Histone H1 variants from K562 cell line (hH1), mouse (mH1) and calf (cH1) thymi were studied by matrix-activated laser desorption/ionization fourier transform ion cyclotron resonance mass-spectroscopy (MALDI-FT-ICR-MS). The proteomics analysis revealed novel post-translational modifications of the histone H1, such as meK34-mH1.4, meK35-cH1.1, meK35-mH1.1, meK75-hH1.2, meK75-hH1.3, acK26-hH1.4, acK26-hH1.3 and acK17-hH1.1. The comparison of the hH1, mH1 and cH1 proteins has demonstrated that the types and positions of the post-translational modifications of the globular domains of the H1.2-H1.4 variants are very conservative. However, the post-translational modifications of the N- and C-terminal tails of H1.2, H1.3 and H1.4 are different. The differences of post-translational modifications in the N- and C-terminal tails of H1.2, H1.3 and H1.4 likely lead to the differences in DNA-H1 and H1-protein interactions.

  7. Post-translational modifications of linker histone H1 variants in mammals.

    Science.gov (United States)

    Starkova, T Yu; Polyanichko, A M; Artamonova, T O; Khodorkovskii, M A; Kostyleva, E I; Chikhirzhina, E V; Tomilin, A N

    2017-02-16

    The covalent modifications of the linker histone H1 and the core histones are thought to play an important role in the control of chromatin functioning. Histone H1 variants from K562 cell line (hH1), mouse (mH1) and calf (cH1) thymi were studied by matrix-activated laser desorption/ionization fourier transform ion cyclotron resonance mass-spectroscopy (MALDI-FT-ICR-MS). The proteomics analysis revealed novel post-translational modifications of the histone H1, such as meK34-mH1.4, meK35-cH1.1, meK35-mH1.1, meK75-hH1.2, meK75-hH1.3, acK26-hH1.4, acK26-hH1.3 and acK17-hH1.1. The comparison of the hH1, mH1 and cH1 proteins has demonstrated that the types and positions of the post-translational modifications of the globular domains of the H1.2-H1.4 variants are very conservative. However, the post-translational modifications of the N- and C-terminal tails of H1.2, H1.3 and H1.4 are different. The differences of post-translational modifications in the N- and C-terminal tails of H1.2, H1.3 and H1.4 likely lead to the differences in DNA-H1 and H1-protein interactions.

  8. H1-Antihistamine Premedication in NSAID-Associated Urticaria.

    Science.gov (United States)

    Trautmann, Axel; Anders, Diana; Stoevesandt, Johanna

    Therapeutic options for pain management are restricted in patients with nonsteroidal anti-inflammatory drug (NSAID)-induced or NSAID-exacerbated urticaria because strong cyclooxygenase (COX)-I inhibiting NSAID cannot be used. Alternative NSAID such as weak COX-I inhibitors or selective COX-II inhibitors are sometimes not sufficiently effective or have potentially troublesome adverse effects. To date, prophylactic premedication with H1-antihistamines is rarely practiced in patients concurrently suffering from recurrent pain and NSAID-associated urticaria. Our data analysis aims to clarify whether prophylactic premedication before the intake of NSAID is effective, safe, and practicable. Data of 21 patients with NSAID-induced or NSAID-exacerbated urticaria who underwent single dose NSAID provocation 30 minutes after premedication with 5 mg desloratadine were retrospectively evaluated. After H1-antihistamine premedication, 17 patients tolerated 16 single dose provocation tests with strong COX-I inhibitors and 2 tests with weak COX-I inhibitors. Despite H1-antihistamine premedication, 2 patients developed acute urticaria after intake of 400 mg ibuprofen. Another 2 patients with acute urticaria after intake of 800 mg ibuprofen tolerated 400 mg ibuprofen and 1000 mg paracetamol, respectively. In the majority of patients with NSAID-induced or NSAID-exacerbated urticaria concurrently suffering from intermittent pain, a premedication regimen with 5 mg desloratadine 30 minutes before intake of a strong COX-I inhibitor seems to be effective, safe, and practicable. Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  9. Underreporting of 2009 H1N1 Influenza Cases

    Centers for Disease Control (CDC) Podcasts

    2009-12-08

    Influenza cases are difficult to track because many people don't go to the doctor or get tested for flu when they're sick. The first months of the 2009 H1N1 influenza pandemic were no different. In this podcast, CDC's Dr. Carrie Reed discusses a study in the December issue of Emerging Infectious Diseases that looked at the actual number of cases reported and estimated the true number of cases when correcting for underreporting.  Created: 12/8/2009 by Emerging Infectious Diseases.   Date Released: 12/8/2009.

  10. À propos du CRDI | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le Centre de recherches pour le développement international (CRDI) finance des travaux de recherche dans les pays en développement afin d'y favoriser la croissance, de réduire la pauvreté et d'impulser des changements positifs à grande échelle.

  11. Renforcement de la recherche en sciences sociales en Iraq | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Cette subvention permettra à l'Iraq Institute for Strategic Studies d'établir les capacités de recherche en sciences sociales du pays en entreprenant une recherche sur le terrain et une enquête dans trois régions, ... Faith, Social Activism and Politics : Role of Faith Based Organizations in Influencing Public Policy (Lebanon).

  12. Partenaires et initiatives | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'African Institute for Mathematical Sciences (AIMS) offre à des diplômés africains une formation rigoureuse en mathématiques. ... L'Initiative de recherche sur la dimension économique de la lutte antitabac finance la recherche novatrice sur les politiques fiscales qui appuient la lutte antitabac dans les pays à faible revenu ...

  13. Changements climatiques | Page 20 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Depuis 1993, le Centre de recherches pour le développement international ( CRDI ), organisme canadien, travaille avec des chercheurs de pays en développement à constituer ce champ de recherche appliquée. Read more about La valeur de l'environnement – Faire appel à l'économie pour forger un avenir sous le signe ...

  14. Renforcement de la recherche en sciences sociales en Iraq - phase ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    appuyer sur le travail accompli au cours de la première phase du projet (103936) pour concevoir et offrir une formation en méthodes et techniques de recherche en sciences sociales destinée à de jeunes intellectuels et réaliser des recherches sur ...

  15. TTI Phase 2 Institutional Support: Consortium pour la Recherche E ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This funding will help strengthen the Consortium pour la recherche économique et sociale's (CRES) role as a credible public policy institution in Senegal by enhancing its ability to provide high-quality, influential, and policy-relevant research. About the Consortium pour la recherche économique et sociale. CRES was ...

  16. Research and development of a gaseous detector PIM (parallel ionization multiplier) dedicated to particle tracking under high hadron rates; Recherche et developpement d'un detecteur gazeux PIM (Parallel Ionization Multiplier) pour la trajectographie de particules sous un haut flux de hadrons

    Energy Technology Data Exchange (ETDEWEB)

    Beucher, J

    2007-10-15

    PIM (Parallel Ionization Multiplier) is a multi-stage micro-pattern gaseous detector using micro-meshes technology. This new device, based on Micromegas (micro-mesh gaseous structure) detector principle of operation, offers good characteristics for minimum ionizing particles track detection. However, this kind of detectors placed in hadron environment suffers discharges which degrade sensibly the detection efficiency and account for hazard to the front-end electronics. In order to minimize these strong events, it is convenient to perform charges multiplication by several successive steps. Within the framework of a European hadron physics project we have investigated the multi-stage PIM detector for high hadrons flux application. For this part of research and development, a systematic study for many geometrical configurations of a two amplification stages separated with a transfer space operated with the gaseous mixture Ne + 10% CO{sub 2} has been performed. Beam tests realised with high energy hadrons at CERN facility have given that discharges probability could be strongly reduced with a suitable PIM device. A discharges rate lower to 10{sup 9} by incident hadron and a spatial resolution of 51 {mu}m have been measured at the beginning efficiency plateau (>96 %) operating point. (author)

  17. Pixel detectors

    CERN Document Server

    Passmore, M S

    2001-01-01

    positions on the detector. The loss of secondary electrons follows the profile of the detector and increases with higher energy ions. studies of the spatial resolution predict a value of 5.3 lp/mm. The image noise in photon counting systems is investigated theoretically and experimentally and is shown to be given by Poisson statistics. The rate capability of the LAD1 was measured to be 250 kHz per pixel. Theoretical and experimental studies of the difference in contrast for ideal charge integrating and photon counting imaging systems were carried out. It is shown that the contrast differs and that for the conventional definition (contrast = (background - signal)/background) the photon counting device will, in some cases, always give a better contrast than the integrating system. Simulations in MEDICI are combined with analytical calculations to investigate charge collection efficiencies (CCE) in semiconductor detectors. Different pixel sizes and biasing conditions are considered. The results show charge shari...

  18. Safety profile of bilastine: 2nd generation H1-antihistamines.

    Science.gov (United States)

    Scaglione, F

    2012-12-01

    Bilastine is a new H1 antagonist with no sedative side effects, no cardiotoxic effects, and no hepatic metabolism. In addition, bilastine has proved to be effective for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria. Pharmacological studies have shown that bilastine is highly selective for the H1 receptor in both in vivo and in vitro studies, and with no apparent affinity for other receptors. The absorption of bilastine is fast, linear and dose-proportional; it appears to be safe and well tolerated at all doses levels in healthy population. Multiple administration of bilastine has confirmed the linearity of the kinetic parameters. The distribution in the brain is undetectable. The safety profile in terms of adverse effects is very similar to placebo in all Phase I, II and III clinical trials. Bilastine (20 mg), unlike cetirizine, does not increase alcohol effects on the CNS. Bilastine 20 mg does not increase the CNS depressant effect of lorazepam. Bilastine 20 mg is similar to placebo in the driving test. Therefore, it meets the current criteria for medication used in the treatment of allergic rhinitis and urticaria.

  19. Pixel Detectors

    CERN Document Server

    Wermes, Norbert

    2005-01-01

    Pixel detectors for precise particle tracking in high energy physics have been developed to a level of maturity during the past decade. Three of the LHC detectors will use vertex detectors close to the interaction point based on the hybrid pixel technology which can be considered the state of the art in this field of instrumentation. A development period of almost 10 years has resulted in pixel detector modules which can stand the extreme rate and timing requirements as well as the very harsh radiation environment at the LHC without severe compromises in performance. From these developments a number of different applications have spun off, most notably for biomedical imaging. Beyond hybrid pixels, a number of monolithic or semi-monolithic developments, which do not require complicated hybridization but come as single sensor/IC entities, have appeared and are currently developed to greater maturity. Most advanced in terms of maturity are so called CMOS active pixels and DEPFET pixels. The present state in the ...

  20. Characterization of Si detectors, search for vertex and potentiality of detecting a light charged Higgs boson in the CMS experiment; Caracterisation des detecteurs silicium, recherche de Vertex et etude du potentiel de decouverte d'un boson de Higgs charge leger dans l'experience CMS

    Energy Technology Data Exchange (ETDEWEB)

    Estre, N

    2004-07-01

    The CMS (compact muon solenoid) detector that will be set on the future LHC (large hadron collider) accelerator will enable us to continue our search for the Higgs boson as well as to look for any hint for a new physics beyond the standard model. CMS is composed of an efficient muon detector, an electromagnetic calorimeter and of a tracker with high spatial resolution, this tracker is the topic of this thesis. The tracker will allow an accurate reconstruction of charged-particles trajectories and the reconstruction of the primary interaction vertex. The tracker's technology is based on micro-strip Si detectors, tests performed with the SPS particle beam show that these detectors have an impact reconstruction efficiency greater than 98% and a piling-up rate limited to 6%. The spatial resolution concerning particle trajectories is about 45 {mu}m for an interval of 183 {mu}m between 2 strips. The simulation for the search for a light charged Higgs boson show that an excess of {tau}{nu}{sub {tau}} + bb-bar + qq-bar' events is possible to be observed for any value of tan({beta}) up to M{sub A} = 122 GeV/c{sup 2} during the first year of operation and up to 136 GeV/c{sup 2} afterwards. With the assumption that this event excess is due to the decay of charged Higgs bosons we can state that the assessment of its mass will be possible till m{sub H} = 150 GeV/c{sup 2} with an accuracy of 15 GeV/c{sup 2}. (A.C.)

  1. Citrullination regulates pluripotency and histone H1 binding to chromatin

    Science.gov (United States)

    Christophorou, Maria A.; Castelo-Branco, Gonçalo; Halley-Stott, Richard P.; Oliveira, Clara Slade; Loos, Remco; Radzisheuskaya, Aliaksandra; Mowen, Kerri A.; Bertone, Paul; Silva, José C. R.; Zernicka-Goetz, Magdalena; Nielsen, Michael L.; Gurdon, John B.; Kouzarides, Tony

    2014-03-01

    Citrullination is the post-translational conversion of an arginine residue within a protein to the non-coded amino acid citrulline. This modification leads to the loss of a positive charge and reduction in hydrogen-bonding ability. It is carried out by a small family of tissue-specific vertebrate enzymes called peptidylarginine deiminases (PADIs) and is associated with the development of diverse pathological states such as autoimmunity, cancer, neurodegenerative disorders, prion diseases and thrombosis. Nevertheless, the physiological functions of citrullination remain ill-defined, although citrullination of core histones has been linked to transcriptional regulation and the DNA damage response. PADI4 (also called PAD4 or PADV), the only PADI with a nuclear localization signal, was previously shown to act in myeloid cells where it mediates profound chromatin decondensation during the innate immune response to infection. Here we show that the expression and enzymatic activity of Padi4 are also induced under conditions of ground-state pluripotency and during reprogramming in mouse. Padi4 is part of the pluripotency transcriptional network, binding to regulatory elements of key stem-cell genes and activating their expression. Its inhibition lowers the percentage of pluripotent cells in the early mouse embryo and significantly reduces reprogramming efficiency. Using an unbiased proteomic approach we identify linker histone H1 variants, which are involved in the generation of compact chromatin, as novel PADI4 substrates. Citrullination of a single arginine residue within the DNA-binding site of H1 results in its displacement from chromatin and global chromatin decondensation. Together, these results uncover a role for citrullination in the regulation of pluripotency and provide new mechanistic insights into how citrullination regulates chromatin compaction.

  2. Ophthalmic antihistamines and H1-H4 receptors.

    Science.gov (United States)

    Wade, Laurie; Bielory, Leonard; Rudner, Shara

    2012-10-01

    Antihistamines exert pharmacologic effects by binding to four histamine receptors (H1-H4) at different affinities, producing variable effects depending on the receptor they predominantly bind to. This review's purpose is to determine the relative potency of antihistamines by comparing their binding affinities to these receptors. Studies on binding affinities of antihistamines to histamine receptors were reviewed and the dissociation constant for inhibitor binding (Ki) analyzed to determine the most and least potent antihistamine for each receptor. We retrieved the binding affinities for nineteen antihistamines. For H1 receptors, pyrilamine exhibited the highest affinity (Ki = 0.8 nM), and thioperamide the lowest (Ki = 280, 000 nM). For H2 receptors, ranitidine exhibited the highest affinity (Ki = 187 nM), and olopatadine the lowest (Ki = 100 ,000 nM). For the recently discovered H3 and H4 receptors, thioperamide exhibited the highest affinity (Ki = 1.1 nM), and olopatadine exhibited the lowest (Ki = 79 ,400 nM), to H3. Data on binding affinities to the H4 receptor exist for: ketotifen, pheniramine, ranitidine, cimetidine and thioperamide. Of these, thioperamide exhibited the highest affinity (Ki = 27 nM), whereas cimetidine and ranitidine exhibited the lowest affinity (Ki = >10, 000 nM) for H4 receptors. This review summarizes the relative potency of antihistamines based on their binding affinities to the four histamine receptors. Although data on binding affinities of antihistamines to the H4 receptor are sparse, it is apparent that further research on these histamine subtypes may open new venues for more direct treatment with a higher therapeutic efficacy on allergic disorders including those affecting the ocular surface.

  3. Technicon H*1 Hematology System: Optical Design Considerations

    Science.gov (United States)

    Colella, G. M.; Tycko, D. H.; Groner, W.

    1988-06-01

    The Technicon H*1 systemTM is a clinical laboratory flow cytometer which performs a complete hematology profile, providing quantitative information on the various types of cells in a blood sample. A light-scattering method, using a HeNe laser, determines in a single flow channel the red cell count, platelet count, and the distributions of red cell volume, red cell hemoglobin concentration, and platelet volume. To accomplish this the scattered light from each red cell in the sample is measured in real time at two angular intervals. The cell volume and the hemoglobin concentration within the cell are derived from these two measurements. Severe accuracy and precision specifications are placed on the medically important red cell count (RBC) and the mean red cell volume (MCV). From the point of view of optical system design, the dominant factor is the requirement that RBC and MCV have precision and accuracy of the order of 2%. Signal-to-noise and scattering-angle definition requirements dictated the choice of a HeNe laser light source. The optics includes an illumination system for producing a sharply defined, uniformly illuminated scattering region and a detection system which must accurately define the accepted scattering angles. In previous cytometric methods for determining MCV only a single quantity was measured for each cell. Such methods cannot disentangle the independent effects of cell size and hemoglobin concentration on the measurement, thus compromising MCV accuracy. The present double-angle scattering method overcomes this accuracy problem. The H*1 red cell method, the supporting optical design and data demonstrating that the use of this technique eliminates interference between the observed red cell indices are presented.

  4. Pandemic H1N1 influenza virus in Chilean commercial turkeys with genetic and serologic comparisons to U.S. H1N1 avian influenza vaccine isolates

    Science.gov (United States)

    Beginning in April 2009, a novel H1N1 influenza virus has caused acute respiratory disease in humans, first in Mexico and then spreading around the world. The resulting pandemic influenza A H1N1 2009 (pH1N1) virus was isolated in swine in Canada in June, 2009, and later in turkey breeders in Chile, ...

  5. Immunity to pre-1950 H1N1 influenza viruses confers cross-protection against the pandemic swine-origin 2009 A (H1N1) influenza virus.

    Science.gov (United States)

    Skountzou, Ioanna; Koutsonanos, Dimitrios G; Kim, Jin Hyang; Powers, Ryan; Satyabhama, Lakshmipriyadarshini; Masseoud, Feda; Weldon, William C; Martin, Maria Del Pilar; Mittler, Robert S; Compans, Richard; Jacob, Joshy

    2010-08-01

    The 2009 H1N1 influenza virus outbreak is the first pandemic of the twenty-first century. Epidemiological data reveal that of all the people afflicted with H1N1 virus, 60 y old have pre-existing neutralizing Abs against the 2009 H1N1 virus. This finding suggests that influenza strains that circulated 50-60 y ago might provide cross-protection against the swine-origin 2009 H1N1 influenza virus. To test this, we determined the ability of representative H1N1 influenza viruses that circulated in the human population from 1930 to 2000, to induce cross-reactivity to and cross-protection against the pandemic swine-origin H1N1 virus, A/California/04/09. We show that exposure of mice to the 1947 virus, A/FM/1/47, or the 1934 virus, A/PR/8/34, induced robust cross-protective immune responses and these mice were protected against a lethal challenge with mouse-adapted A/California/04/09 H1N1 virus. Conversely, we observed that mice exposed to the 2009 H1N1 virus were protected against a lethal challenge with mouse-adapted 1947 or 1934 H1N1 viruses. In addition, exposure to the 2009 H1N1 virus induced broad cross-reactivity against H1N1 as well as H3N2 influenza viruses. Finally, we show that vaccination with the older H1N1 viruses, particularly A/FM/1/47, confers protective immunity against the 2009 pandemic H1N1 virus. Taken together, our data provide an explanation for the decreased susceptibility of the elderly to the 2009 H1N1 outbreak and demonstrate that vaccination with the pre-1950 influenza strains can cross-protect against the pandemic swine-origin 2009 H1N1 influenza virus.

  6. Neutron detector

    Science.gov (United States)

    Stephan, Andrew C [Knoxville, TN; Jardret,; Vincent, D [Powell, TN

    2011-04-05

    A neutron detector has a volume of neutron moderating material and a plurality of individual neutron sensing elements dispersed at selected locations throughout the moderator, and particularly arranged so that some of the detecting elements are closer to the surface of the moderator assembly and others are more deeply embedded. The arrangement captures some thermalized neutrons that might otherwise be scattered away from a single, centrally located detector element. Different geometrical arrangements may be used while preserving its fundamental characteristics. Different types of neutron sensing elements may be used, which may operate on any of a number of physical principles to perform the function of sensing a neutron, either by a capture or a scattering reaction, and converting that reaction to a detectable signal. High detection efficiency, an ability to acquire spectral information, and directional sensitivity may be obtained.

  7. Search for non-baryonic dark matter with cryogenic detectors based on ionisation and heat detection. Analysis of experimental data from the Edelweiss-I experiment; Recherche de la matiere noire non-baryonique a l'aide de detecteurs cryogeniques a double composante ionisation et chaleur: Analyse et Interpretation des donnees de l'experience EDELWEISS-I

    Energy Technology Data Exchange (ETDEWEB)

    Sanglard, V

    2005-11-15

    The method of direct detection of WIMPs (weakly interactive massive particles) that are present in the halo of our galaxy rests on the detection of their interaction with a target nucleus. The Edelweiss experiment uses this technique with 3 cryogenic detectors operating on 2 modes ionization and heat. Each detector is made of a 320 g germanium crystal with 2 faces equipped with electrodes. In order to improve the collection of charges, an amorphous layer of Ge or Si is laid between the crystal surface and the electrodes. The validation of the detector system has been made with Co{sup 57} and Cs{sup 137} gamma sources and a Cf{sup 252} neutron source. We present a comparison with simulation results and experimental data for the validation of the response to nuclear recoils. The whole experimental data collected by Edelweiss-I from 2000 till 2003 has been analysed. 40 events have been selected, 6 among them with an energy over 30 keV. Limits for the interaction cross-section between a WIMP and a nucleon have been deduced from the experimental data. The Yellin method has enabled us to determine a limit without knowing the background noise. The best sensitivity appears to be 1.5*10{sup -6} pb for a WIMP's mass of 80 GeV/c{sup 2} and a confidence level of 90 per cent. In terms of events, the limit for an energy range of 30 - 100 keV is 0.12 events per kg and per day. (A.C.)

  8. Narcolepsy and H1N1 vaccination: a link?

    Science.gov (United States)

    Thebault, Simon; Vincent, Angela; Gringras, Paul

    2013-11-01

    A number of European countries have reported a dramatic increase in the rates of childhood narcolepsy with cataplexy in children immunized with a split-virion adjuvanted swine flu vaccine. Here, we review the strengths and weaknesses of these epidemiological studies and possible neuroimmunological mechanisms. Initial concerns of a 13-fold increased relative risk of narcolepsy were raised by the Scandinavian health protection agencies in 2010. Subsequent retrospective studies support these findings in Canada, France, Ireland, England and Denmark. The cases are predominantly young children who present with severe and rapid onset of cataplexy as well as narcolepsy often within a few weeks of vaccination. The proposed mechanism for postvaccination narcolepsy is one in which an environmental trigger causes or enhances an antibody-mediated autoimmune response in patients with a preexisting genetic susceptibility. However, there have not yet been any reports of specific autoimmunity, either antibody or T-cell-mediated. There is a strong association between narcolepsy and H1N1 vaccination. However, whether this reflects a true increase in affected individuals or a hastening of disease onset in individuals who would otherwise have developed narcolepsy later will become clear in the coming years. The pathological explanation of this association and narcolepsy is likely to be autoimmune, although supportive evidence is lacking.Video abstract available: See the Video Supplementary Digital Content 1 (http://links.lww.com/COPM/A9).

  9. Physics from the first year of H1 at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Kiesling, C. [Max-Planck-Institut fuer Physik, Muenchen (Germany)

    1994-12-01

    In this report the author summarizes the results from the H1 experiment at HERA, using the data from the first year of running, 1992, when an integrated luminosity of 25 nb{sup {minus}1} has been recorded. These results include photoproduction, the measurement of the deep inelastic scattering, both for neutral current reactions and the search for physics beyond the Standard Model. Apart from the measurement of a moderate rise in the total photoproduction cross section, clear evidence is seen for hard interactions in single particle spectra and jet production, requiring a {open_quotes}resolved{close_quotes} photon as expected in QCD. The investigation of the global properties of hadronic final states in deep inelastic scattering demonstrates the need for further improvement of present QCD models. Evidence is found for a class of events with diffractive characteristics, exhibiting a large gap of hadronic energy flow about the proton direction. The proton structure function F{sub 2}{sup p}(x, Q{sup 2}) has been measured for neutral current events for Bjorken x in the range 10{sup {minus}4} - 10{sup {minus}2} and Q{sup 2} > 5 GeV{sup 2}, showing a steep rise towards small x. Furthermore, using 1993 data, a measurement of the cross section for charged current events is presented, clearly demonstrating, for the first time, the propagator effect of the W boson. Finally, new limits on leptoquarks, leptogluons, and excited electrons have been determined.

  10. Constrained H1-regularization schemes for diffeomorphic image registration

    Science.gov (United States)

    Mang, Andreas; Biros, George

    2017-01-01

    We propose regularization schemes for deformable registration and efficient algorithms for their numerical approximation. We treat image registration as a variational optimal control problem. The deformation map is parametrized by its velocity. Tikhonov regularization ensures well-posedness. Our scheme augments standard smoothness regularization operators based on H1- and H2-seminorms with a constraint on the divergence of the velocity field, which resembles variational formulations for Stokes incompressible flows. In our formulation, we invert for a stationary velocity field and a mass source map. This allows us to explicitly control the compressibility of the deformation map and by that the determinant of the deformation gradient. We also introduce a new regularization scheme that allows us to control shear. We use a globalized, preconditioned, matrix-free, reduced space (Gauss–)Newton–Krylov scheme for numerical optimization. We exploit variable elimination techniques to reduce the number of unknowns of our system; we only iterate on the reduced space of the velocity field. Our current implementation is limited to the two-dimensional case. The numerical experiments demonstrate that we can control the determinant of the deformation gradient without compromising registration quality. This additional control allows us to avoid oversmoothing of the deformation map. We also demonstrate that we can promote or penalize shear whilst controlling the determinant of the deformation gradient. PMID:29075361

  11. Bourse de recherche : Initiative de recherche concertée sur l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    6 sept. 2017 ... La priorité sera accordée aux propositions comportant des objectifs précis et réalistes de même qu'une méthodologie clairement définie. Qui plus est, la proposition doit démontrer la pertinence de la recherche proposée par rapport aux débats locaux, nationaux et régionaux sur les politiques dans au ...

  12. Bourse de recherche — Comité consultatif d'éthique de la recherche ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    7 sept. 2016 ... Coordonner des séminaires et des événements de formation sur l'éthique de la recherche pour les employés du CRDI;; Maintenir et enrichir la base de ... expliquer en quoi l'expérience qui sera acquise grâce à la bourse cadre avec ses objectifs professionnels et reconnaître la double nature du poste ...

  13. Perspectives | Page 2 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Des experts du CRDI examinent les questions et les approches sur lesquelles se penchent les acteurs du développement international, ainsi que le rôle de la recherche dans la mise au point de solutions.

  14. La Fondation Azrieli | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    http://www.azrielifoundation.org/fr/. Programme conjoint canado-israélien de recherche en santé. Le Programme conjoint canado-israélien de recherche en santé d'une durée de sept années disposera d'un budget de 35 millions CAD, qui mettra à contribution les compétences scientifiques particulières... Voir davantage

  15. La recherche-action participative facilite l'adaptation aux ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    15 mai 2012 ... Ces travaux comprenaient un riche portefeuille de recherches sur l'adaptation aux changements climatiques dans le secteur de l'agriculture. La méthodologie privilégiée dans le cadre du programme, la recherche-action participative, s'est avérée fructueuse et a permis de mettre au point et de déployer des ...

  16. Livres | Page 6 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ce livre décrit dix ans de recherche, d'innovation méthodologique et de leçons découlant de l'African Highlands Initiative (AHI), un programme écorégional de recherche pour le développement ayant p. Directeur(s) : Laura German, Jeremias Mowo, Tilahun Amede et Kenneth Masuki. Maison(s) d'édition : Earthscan, CRDI.

  17. Soutien institutionnel à des organismes de recherche sur les ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Financée par plusieurs bailleurs de fonds, l'Initiative Think tank du CRDI a pour objet de renforcer des organismes indépendants voués à la recherche sur les politiques (" think tanks ") établis dans les pays en développement de façon à permettre à ces organismes de produire des recherches rigoureuses qui serviront à ...

  18. Publications | Page 32 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Miser sur des chefs de file dans la recherche sur l'économie du travail. En dépit de l'importance de sa main-d'œuvre dans la région, l'Asie souffre d'un manque de spécialistes en recherche et en analyse du travail. Pour le combler, le CRDI soutient la formation, le.

  19. Lebanon : tous les projets | Page 2 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Activités de recherche, de diffusion et de réseautage aux fins de la lutte antitabac au Liban. Projet. Le groupe de recherche sur la lutte antitabac de l'Université américaine de Beyrouth (AUB) est une équipe pluridisciplinaire composée de professionnels des départements des sciences de la santé, de médecine, de chimie ...

  20. Anindya Chatterjee | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le Dr Anindya Chatterjee est directeur du Bureau régional de l'Asie du CRDI, qui est situé à New Delhi, en Inde. Au cours de sa carrière, le Dr Chatterjee a mis à profit ses qualités de chef de file en recherche, en gestion de la recherche et en élaboration de politiques et de programmes dans le domaine de la santé ...

  1. Publications | Page 42 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Titulaire d'une bourse de recherche du CRDI, Shelley Jones s'est rendue en Ouganda afin d'étudier les obstacles qui empêchent les jeunes femmes de poursuivre leurs études secondaires. Des emplois décents pour les jeunes Péruviens. En Amérique latine, on a besoin de toute urgence de recherches rigoureuses et ...

  2. Partenariat en recherche ANASE-Canada | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le Partenariat en recherche ANASE-Canada contribuera à renforcer les relations entre le Canada et l'Association des nations de l'Asie du Sud-Est (ANASE) grâce à la recherche et au dialogue sur les politiques portant sur des questions d'intérêt commun dans la région. L'organisme bénéficiaire, le Centre for ...

  3. Regard sur la recherche dans son ensemble | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Selon Andréanne Martel, la recherche et le travail qu'elle a menés au CRDI en tant que titulaire d'une bourse de recherche en 2016 sont inséparables. Mme Martel cherchait à comprendre si un projet visant à offrir un accès à la justice aux victimes de violence sexuelle à Mumbai s'était prolongé et avait été reproduit, ...

  4. Appel à propositions Bourse de recherche 2016 du CRDI

    International Development Research Centre (IDRC) Digital Library (Canada)

    Carole Labrie

    6 août 2015 ... Candidats présentant une demande une deuxième fois. Veuillez noter que les observations des personnes qui ont évalué votre première demande ne seront pas disponibles. Considérations d'ordre éthique. La recherche soutenue par une bourse de recherche devrait être conforme à la dernière édition de.

  5. Publications | Page 94 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La recherche en santé mentale reconnaît plusieurs habiletés aux travailleurs sociaux. Cependant, lorsqu''il est question de médication, élément central du plan de traitement en santé mentale, on constate que l''on attribue surtout aux travailleurs sociaux le rôle de veiller à l''observance de ce... Recherche transnationale sur ...

  6. Renforcement de la recherche en sciences sociales en Iraq | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    On estime que par conséquent, le petit nombre de facultés des sciences sociales existantes sont dans un piètre état. Cette subvention permettra à l'Iraq Institute for Strategic Studies d'établir les capacités de recherche en sciences sociales du pays en entreprenant une recherche sur le terrain et une enquête dans trois ...

  7. Affaires mondiales Canada | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Par exemple, des équipes de recherche vietnamiennes et canadiennes ont mis au point des farines instantanées et des céréales pour bébés enrichies de micronutriments, et ce, au moyen de cultures et d'installations de transformation locales. Affaires mondiales Canada, le CRDI et les Instituts de recherche en santé du ...

  8. Annonce des boursiers de recherche du Mekong Network | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    15 avr. 2016 ... Le Greater Mekong Subregion Research Network (GMS-Net), de concert avec le Centre de recherches pour le développement international (CRDI), a lancé un appel à propositions ayant pour but de mettre en commun les recherches de qualité supérieure en matière de développement visant à améliorer ...

  9. Search for Higgs bosons in 2 lepton events and validation of a background noise detector in the DELPHI experiment; Recherche de bosons de higgs neutres dans les evenements a deux leptons isoles a LEP2 et mise au point d'un detecteur de controle du bruit de fond dans l'experience DELPHI

    Energy Technology Data Exchange (ETDEWEB)

    Lethuillier, M. [CEA/Saclay, Dept. d' Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l' Instrumentation Associee (DAPNIA), 91 - Gif-sur-Yvette (France)]|[Paris-7 Univ., 75 (France)

    1999-04-01

    This thesis presents two studies made within the DELPHI experiment in the context of the energy rise of the LEP collider. The first study concerns the setting up of a silicon plate detector that allows a continuous measurement of the background generated by the beams, particularly synchrotron radiation, the intensity of which increases strongly with the beam energy. This silicon monitor ensures a better safety of the more fragile DELPHI sub-detectors, especially the Time Projection Chamber, and gives a very precise measurement of the time of flight and energy of particles (2.1 ns and 3.6 keV resolution), thus allowing to identify the machine elements from which the background originates. The second study is devoted to the search for a neutral Higgs boson, produced in association with a Z boson decaying into an electron or a muon pair; we have searched for Higgs boson decays in b quarks, {tau} leptons or into invisible decay products as it is predicted by some supersymmetry scenarios. No signal has been observed in the 54 and 158 pb{sup -1} data recorded at {radical}s=183 and 189 GeV. Combining this result with those from other search channels, the hypothesis for a standard Higgs boson with a mass less than 94.5 GeV/c{sup 2} can be excluded at more than 95 % confidence level. In the frame of the Minimal Supersymmetric Model, this limit becomes 82.4 GeV/c{sup 2}, independently of the free parameter tan{beta}. Finally, as far as invisible decays are concerned, the limit becomes 90.2 GeV/c{sup 2}, independently of the branching ratio into invisible decay products. (author)

  10. Search for gluinos decaying into b-jets and transverse missing energy with the detector D0 at the Tevatron; Recherche de gluinos dans la topologie a jets de quarks b et energie transverse manquante avec le detecteur D0 au TeVatron

    Energy Technology Data Exchange (ETDEWEB)

    Millet, Th

    2007-05-15

    The standard model of particle physics is the model of reference to explain the subatomic phenomena. This theoretical model has been successful for about 35 years. Although it has never been directly refuted, it has some theoretical and experimental limitations at high energy. That is why several new theories are trying to propose some extensions for this model. The supersymmetry is a possible extension, which is appreciated for its theoretical neatness. The work, which is presented in this manuscript, is dedicated to the search for a supersymmetric signal. The main feature of this signal are the presence of 4 b-jets and the high transverse missing energy. This search have been performed with the Run II data collected with the D0 detector from April 2003 to March 2006 (1 fb{sup -1}). The signature of such a topology needs a good energy resolution for the jets and a precise measure of the transverse missing energy. Consequently, it is essential to understand the information given by the calorimeter which is one of the crucial parts of the detector for such a search. The presence of the b-jets in the final state implies a efficient b-tagging. The b-tagging is a discriminant variable for the signal with respect to the standard model background. The hadronic colliders like the Tevatron are characterized by a QCD cross section which is many orders of magnitude larger than the supersymmetric signal cross section. Therefore, it is important to find fast and efficient selection cuts based on the calorimeter at the trigger level. The most important part of my work before the signal search has been dedicated on the study and the design of the trigger conditions for the jets and transverse missing energy signals. (author)

  11. Caracterització funcional de dBigH1: la variant germinal i embrionària d'histona H1 a Drosophila

    OpenAIRE

    Pérez Montero, Salvador

    2015-01-01

    Durant el desenvolupament d’aquesta tesi doctoral hem identificat i caracteritzat la variant d’histona H1 present a la línia germinal i l’embrió primerenc de Drosophila melanogaster. Els metazous contenen múltiples variants d’histona H1. Particularment, la majoria d’espècies estudiades contenen diverses variants d’histona H1 que reemplacen les H1 somàtiques a la línia germinal i als primers estadis del desenvolupament embrionari. Drosophila era l’excepció ja que, fins ara tan sols es con...

  12. Recherche et développement

    Directory of Open Access Journals (Sweden)

    Icart Jean-Claude

    2000-03-01

    Full Text Available La présence des sciences sociales au centre de ce dossier, Afrique, plantation et développement, n’est pas seulement significative d’une situation propre au problème du développement des pays du Sud, et de l’Afrique en particulier. Les perspectives, au Nord, d’une agriculture multifonctionnelle, plus sensible aux dimensions territoriales et sociales des ses activités, confrontent la recherche agronomique à des problèmes similaires de médiation, liée aux mêmes impératifs de conciliation entre démarche scientifique et action, imposant le même recours aux analyses sur le milieu socio-économique.

  13. Radiation detector

    Energy Technology Data Exchange (ETDEWEB)

    Taleyarkhan, Rusi P.

    2017-06-27

    Alpha particle detecting devices are disclosed that have a chamber that can hold a fluid in a tensioned metastable state. The chamber is tuned with a suitable fluid and tension such that alpha emitting materials such as radon and one or more of its decay products can be detected. The devices can be portable and can be placed in areas, such as rooms in dwellings or laboratories and used to measure radon in these areas, in situ and in real time. The disclosed detectors can detect radon at and below 4 pCi/L in air; also, at and below 4,000 pCi/L or 300 pCi/L in water.

  14. 20 CFR 655.705 - What Federal agencies are involved in the H-1B and H-1B1 programs, and what are the...

    Science.gov (United States)

    2010-04-01

    ... offer a position filled by an H-1B nonimmigrant to an equally or better qualified United States worker....S. workers, to offer the job to U.S. applicants who are equally or better qualified than the H-1B... EMPLOYMENT OF FOREIGN WORKERS IN THE UNITED STATES Labor Condition Applications and Requirements for...

  15. Finding the Higgs boson of the standard model in the channel ZH → e+e-b$\\bar{b}$ with the D0 detector at the Tevatron; Recherche du boson de Higgs du nideke standard dans le canal ZH → e+e-b$\\bar{b}$ avec le detecteur DØ aupres du Tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Calpas, Betty Constante [Univ. of the Mediterranean, Marseille (France)

    2010-06-11

    The organization of this thesis consists of three main ideas: the first presents the theoretical framework and experimental, as well as objects used in the analysis and the second relates to the various work tasks of service that I performed on the calorimeter, and the third is the search for the Higgs boson in the channel ZH → e+e-b$\\bar{b}$. Thus, this thesis has the following structure: Chapter 1 is an introduction to the standard model of particle physics and the Higgs mechanism; Chapter 2 is an overview of the complex and the acceleration of the Tevatron at Fermilab DØ detector; Chapter 3 is an introduction to physical objects used in this thesis; Chapter 4 presents the study made on correcting the energy measured in the calorimeter; Chapter 5 describes the study of certification of electrons in the calorimeter; Chapter 6 describes the study of certification of electrons in the intercryostat region of calorimeter; Chapter 7 Detailed analysis on the search for Higgs production in the channel ZH → e+e-b$\\bar{b}$; and Chapter 8 presents the final results of the calculations of upper limits to the production cross section of the Higgs boson on a range of low masses.

  16. Search for new physics in the jets and missing transverse energy topology with the D0 detector at the Tevatron; Recherche de nouvelle physique dans la topologie a jets et energie transverse manquante avec le detecteur D0 au TeVatron

    Energy Technology Data Exchange (ETDEWEB)

    Makovec, N

    2006-05-15

    Although the standard model of particle physics agrees perfectly with experimental data, it is unlikely the final theory describing particles and their interactions. New phenomena has been searched in the jets and missing transverse energy topology. Such phenomena may be due to the pair production of leptoquarks decaying into a quark and a neutrino or the pair production of stops decaying into a charm and a neutralino which is assumed to be the lightest supersymmetric particle. These searches have been performed with the Ddiamter detector at hadronic collider TeVatron with a center of mass energy of 1.96 TeV. This kind of searches needs a good understanding of the jet energy calibration. The determination of the relative jet energy scale has allowed us to reduce the systematic uncertainties on the jet energy measurement when comparing the data and the simulation. Moreover a new method has been developed in order to correct simulated jets for the differences observed in the jet energy scale, the jet energy resolution and the jet reconstruction efficiency between the data and the simulation. The data analysis, performed with an integrated luminosity of 310 pb{sup -1}, has not observed any excess. This result are interpreted in terms of limit on the mass of the particles: leptoquarks with a mass smaller than 136 GeV and stops with a mass smaller than 131 GeV, for a neutralino mass equal to 46 GeV, are excluded with 95% confidence level. (author)

  17. Une santé branchée sur la recherche : Perspectives du Conseil de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2001-10-09

    Une santé branchée sur la recherche : Perspectives du Conseil de la recherche en santé pour le développement. Couverture du livre Une santé branchée sur la recherche : Perspectives du Conseil de la recherche. Editor(s):. Victor Neufeld et Nancy Johnson. Publisher(s):. CRDI. October 9, 2001. ISBN: Épuisé. 260 pages.

  18. Une santé branchée sur la recherche : Perspectives du Conseil de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Une santé branchée sur la recherche : Perspectives du Conseil de la recherche en santé pour le développement. Couverture du livre Une santé branchée sur la recherche : Perspectives du Conseil de la recherche. Directeur(s) : Victor Neufeld et Nancy Johnson. Maison(s) d'édition : CRDI. 9 octobre 2001. ISBN : Épuisé.

  19. En quoi l'excellence en recherche importe-t-elle ? | CRDI - Centre ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    30 nov. 2016 ... Qualité de la Recherche Plus (QR+) : une approche holistique d'évaluation de la recherche (2016) explore la nouvelle démarche adoptée par le CRDI pour évaluer la recherche ainsi que les motifs de l'évaluation fondée sur davantage que la qualité de la recherche scientifique. (Disponible en anglais ...

  20. H1DS: A new web-based data access system

    Energy Technology Data Exchange (ETDEWEB)

    Pretty, D.G., E-mail: david.pretty@anu.edu.au; Blackwell, B.D.

    2014-05-15

    Highlights: • We present H1DS, a new RESTful web service for accessing fusion data. • We examine the scalability and extensibility of H1DS. • We present a fast and user friendly web browser client for the H1DS web service. • A summary relational database is presented as an application of the H1DS API. - Abstract: A new data access system, H1DS, has been developed and deployed for the H-1 Heliac at the Australian Plasma Fusion Research Facility. The data system provides access to fusion data via a RESTful web service. With the URL acting as the API to the data system, H1DS provides a scalable and extensible framework which is intuitive to new users, and allows access from any internet connected device. The H1DS framework, originally designed to work with MDSplus, has a modular design which can be extended to provide access to alternative data storage systems.

  1. CLIC Detector Power Requirements

    CERN Document Server

    Gaddi, A

    2013-01-01

    An estimate for the CLIC detector power requirements is outlined starting from the available data on power consumptions of the four LHC experiments and considering the differences between a typical LHC Detector (CMS) and the CLIC baseline detector concept. In particular the impact of the power pulsing scheme for the CLIC Detector electronics on the overall detector consumption is considered. The document will be updated with the requirements of the sub-detector electronics once they are more defined.

  2. Alliances internationales de recherche universités-communautés ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les Alliances internationales de recherche universités-communautés (ARUC internationales) sont une initiative conjointe du Conseil de recherches en sciences humaines (CRSH) du Canada et du CRDI. Elles visent à favoriser la recherche novatrice, la formation et la production de nouvelles connaissances sur les ...

  3. Ce que nous faisons | Page 93 | CRDI - Centre de recherches pour ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Sujet(s): Recherche Agricole, Cultures Vivrières, Production Alimentaire, Petits Cultivateurs, Bourses De Recherche. Région(s): Mondial. Lancé conjointement par l'Agence canadienne de développement international (ACDI) et le CRDI, le Fonds canadien de recherche sur la sécurité alimentaire internationale (FCRSAI) est ...

  4. Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata

    DEFF Research Database (Denmark)

    Dao, Trong Tuan; Nguyen, Phi Hung; Lee, Hong Sik

    2011-01-01

    -8) chalcones were isolated as active principles from the acetone extract of Glycyrrhiza inflata. Compounds 3 and 6 without prenyl group showed strong inhibitory effects on various neuraminidases from influenza viral strains, H1N1, H9N2, novel H1N1 (WT), and oseltamivir-resistant novel H1N1 (H274Y) expressed...

  5. File list: Oth.ALL.20.H1.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.ALL.20.H1.AllCell dm3 TFs and others H1 All cell types SRX287934,SRX287933,SRX2...87755,SRX287756 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Oth.ALL.20.H1.AllCell.bed ...

  6. Search for Higgs Boson of Minimal Standard Model in the hadronic final states with the detector ALEPH at LEP 2; Recherche du boson de Higgs du Modele Standard Minimal dans les etats finals hadroniques avec le detecteur ALEPH a LEP 2

    Energy Technology Data Exchange (ETDEWEB)

    Deschamps, Olivier [Lab. de Physique Corpusculaire, Clermont-Ferrand-2 Univ., 63 - Aubiere (France)

    1999-04-16

    In the Standard Model framework of the particle physics the mass of fermions and electroweak gauge boson mass is related to a scalar sector. In the Minimal Version of the Standard Model, a neutral scalar particle is predicted: the Higgs boson. Its mass is a free parameter of the model. The search for this boson has been actively performed at the LEP collider and it has been extended by the recent increase of its energy (LEP 2). In addition, due to the increase of the signal to background ratio at LEP 2, the data analysis has been extended to new channels. This is particularly the case of the dominant, HZ {yields} hadrons, channel leading to 65% of the e{sup +}e{sup -} {yields} HZ production process final states at LEP. The aim of the work presented in this document, is the search of the Minimal Standard Model Higgs boson in the fully hadronic final state data recorded by the ALEPH detector at LEP 2 energies. A selection tool based on an artificial neural network multi-variate method, has been developed in order to separate the signal process from known Standard Model background processes. The neural network method allows to combine non-linearly the information describing the signal, and to reach performances better than those obtained by classical method based on cuts. No evidence of signal has been seen in the data collected by ALEPH up to {radical}s = 189 GeV. Thirty-two candidates has been selected in agreement with the 26.3 events expected for the background processes. Combining all channels from Higgs boson search, the limit m{sub H} > 90.2 GeV/c{sup 2} is obtained with a 95% confidence level. (author)

  7. Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 based vaccines.

    Directory of Open Access Journals (Sweden)

    Balaji Manicassamy

    2010-01-01

    Full Text Available The recent 2009 pandemic H1N1 virus infection in humans has resulted in nearly 5,000 deaths worldwide. Early epidemiological findings indicated a low level of infection in the older population (>65 years with the pandemic virus, and a greater susceptibility in people younger than 35 years of age, a phenomenon correlated with the presence of cross-reactive immunity in the older population. It is unclear what virus(es might be responsible for this apparent cross-protection against the 2009 pandemic H1N1 virus. We describe a mouse lethal challenge model for the 2009 pandemic H1N1 strain, used together with a panel of inactivated H1N1 virus vaccines and hemagglutinin (HA monoclonal antibodies to dissect the possible humoral antigenic determinants of pre-existing immunity against this virus in the human population. By hemagglutinination inhibition (HI assays and vaccination/challenge studies, we demonstrate that the 2009 pandemic H1N1 virus is antigenically similar to human H1N1 viruses that circulated from 1918-1943 and to classical swine H1N1 viruses. Antibodies elicited against 1918-like or classical swine H1N1 vaccines completely protect C57B/6 mice from lethal challenge with the influenza A/Netherlands/602/2009 virus isolate. In contrast, contemporary H1N1 vaccines afforded only partial protection. Passive immunization with cross-reactive monoclonal antibodies (mAbs raised against either 1918 or A/California/04/2009 HA proteins offered full protection from death. Analysis of mAb antibody escape mutants, generated by selection of 2009 H1N1 virus with these mAbs, indicate that antigenic site Sa is one of the conserved cross-protective epitopes. Our findings in mice agree with serological data showing high prevalence of 2009 H1N1 cross-reactive antibodies only in the older population, indicating that prior infection with 1918-like viruses or vaccination against the 1976 swine H1N1 virus in the USA are likely to provide protection against the 2009

  8. A search for R-parity violating squark production with the H1 experiment at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, Michael Clemens

    2011-12-15

    A search for R-parity violating supersymmetry is performed in the complete HERA data set taken at a centre-of-mass energy of {radical}(s)=319 GeV with the H1 detector. The integrated luminosity of the data sets corresponds to 255 pb{sup -1} of positron-proton, and 183 pb{sup -1} of electron-proton collision data. By introducing a lepton-quark-squark coupling {lambda}{sup '} the resonant production of single squarks is expected. Several exclusive selection channels, based on the topologies of final states expected from direct squark decays, and squark decays via gauginos are defined. The selection channels are based on an electron or a neutrino in the final state, and may contain further jets and leptons. All of the selection channels show a good agreement with the background expectation from standard model processes. The results are interpreted in terms of exclusion limits, obtained for the minimal supersymmetric standard model, and for the minimal supergravity model, constraining the strength of the R-parity violating couplings {lambda}{sub 1j1}{sup '} and {lambda}{sub 11k}{sup '}, and the supersymmetric model parameters, under the single coupling dominance hypothesis. For an R{sub p} coupling strength comparable to the electromagnetic coupling strength, {lambda}{sub 1j1}{sup '} or {lambda}{sub 11k}{sup '}={radical}(4{pi}{alpha}{sub em})=0.3, squark masses up to 275 GeV are excluded for u{sup j}{sub L} squarks, with d{sup k}{sub R} squarks further excluded up to 290 GeV, for all three squark generations j,k=1,2,3 at the 95% confidence level. (orig.)

  9. Unpolarized neutral current e{sup {+-}}p cross section measurements at the H1 experiment, HERA

    Energy Technology Data Exchange (ETDEWEB)

    Habib, Shiraz Z.

    2009-11-15

    Measurements of the unpolarized inclusive neutral current reduced cross section in e{sup {+-}}p scattering at a center of mass energy {radical}(s) {approx_equal} 319 GeV are presented. The data was collected by the H1 detector during the HERA II running phase, after the 2000 luminosity upgrade, and corresponds to an integrated luminosity of 145 pb{sup -1} and 167 pb{sup -1} for the e{sup -}p and e{sup +}p periods respectively. The cross section measurements were made for the negative four-momentum transfer squared range 65{<=} Q{sup 2}{<=}30000 GeV{sup 2} and Bjorken-x range 0.00085{<=}x{<=}0.65. Dedicated measurements at inelasticity y=0.75 and Q{sup 2}{<=}800 GeV{sup 2} are also made. The details of the analysis are presented here. The cross section measurements presented here are found to agree with previously published data as well as predictions determined from various NLO QCD fits. Scaling violation of the F{sub 2} structure function as well differences between the e{sup -} and e{sup +} cross sections at high Q{sup 2} due to the xF{sub 3} structure function have been observed. The cross sections in the range Q{sup 2}{<=}800 GeV{sup 2} at inelasticity y=0.75 suggest non-zero values of the longitudinal structure function F{sub L}. (orig.)

  10. MUON DETECTOR

    CERN Multimedia

    F. Gasparini

    DT As announced in the previous Bulletin MU DT completed the installation of the vertical chambers of barrel wheels 0, +1 and +2. 242 DT and RPC stations are now installed in the negative barrel wheels. The missing 8 (4 in YB-1 and 4 in YB-2) chambers can be installed only after the lowering of the two wheels into the UX cavern, which is planned for the last quarter of the year. Cabling on the surface of the negative wheels was finished in May after some difficulties with RPC cables. The next step was to begin the final commissioning of the wheels with the final trigger and readout electronics. Priority was giv¬en to YB0 in order to check everything before the chambers were covered by cables and services of the inner detectors. Commissioning is not easy since it requires both activity on the central and positive wheels underground, as well as on the negative wheels still on the surface. The DT community is requested to commission the negative wheels on surface to cope with a possible lack of time a...

  11. Mechanistic Study of the Stereoselective Hydroxylation of [2-2 H1 ,3-2 H1 ]Butanes Catalyzed by Cytochrome P450 BM3 Variants.

    Science.gov (United States)

    Yang, Chung-Ling; Lin, Cheng-Hung; Luo, Wen-I; Lee, Tsu-Lin; Ramu, Ravirala; Ng, Kok Yaoh; Tsai, Yi-Fang; Wei, Guor-Tzo; Yu, Steve S-F

    2017-02-21

    Engineered bacterial cytochrome P450s are noted for their ability in the oxidation of inert small alkanes. Cytochrome P450 BM3 L188P A328F (BM3 PF) and A74E L188P A328F (BM3 EPF) variants are able to efficiently oxidize n-butane to 2-butanol. Esterification of the 2-butanol derived from this reaction mediated by the aforementioned two mutants gives diastereomeric excesses (de) of -56±1 and -52±1 %, respectively, with the preference for the oxidation occurring at the C-HS bond. When tailored (2R,3R)- and (2S,3S)-[2-2 H1 ,3-2 H1 ]butane probes are employed as substrates for both variants, the obtained de values from (2R,3R)-[2-2 H1 ,3-2 H1 ]butane are -93 and -92 % for BM3 PF and EPF, respectively; whereas the obtained de values from (2S,3S)-[2-2 H1 ,3-2 H1 ]butane are 52 and 56 % in the BM3 PF and EPF systems, respectively. The kinetic isotope effects (KIEs) for the oxidation of (2R,3R)-[2-2 H1 ,3-2 H1 ]butane are 7.3 and 7.8 in BM3 PF and EPF, respectively; whereas KIEs for (2S,3S)-[2-2 H1 ,3-2 H1 ]butanes are 18 and 25 in BM3 PF and EPF, respectively. The discrepancy in KIEs obtained from the two substrates supports the two-state reactivity (TSR) that is proposed for alkane oxidation in cytochrome P450 systems. Moreover, for the first time, experimental evidence for tunneling in the oxidation mediated by P450 is given through the oxidation of the C-HR bond in (2S,3S)-[2-2 H1 ,3-2 H1 ]butane. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Inverse agonistic activity of antihistamines and suppression of histamine H1 receptor gene expression.

    Science.gov (United States)

    Mizuguchi, Hiroyuki; Ono, Shohei; Hattori, Masashi; Fukui, Hiroyuki

    2012-01-01

    Histamine H(1) receptor (H1R) expression influences the severity of allergy symptoms. We examined the effect of inverse agonists on H1R gene expression. Two inverse agonists (carebastine and mepyramine), but not the neutral antagonist oxatomide, decreased inositol phosphate accumulation. The inverse agonists also decreased H1R gene expression and down-regulated H1R mRNA below basal expression, while basal H1R mRNA expression was maintained after oxatomide treatment. These results suggest that inverse agonists more potently alleviate allergy symptoms by not only inhibiting stimulus-induced up-regulation of H1R gene expression but also by suppressing basal histamine signaling through their inverse agonistic activity.

  13. Detector simulation needs for detector designers

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, G.G.

    1987-11-01

    Computer simulation of the components of SSC detectors and of the complete detectors will be very important for the designs of the detectors. The ratio of events from interesting physics to events from background processes is very low, so detailed understanding of detector response to the backgrounds is needed. Any large detector for the SSC will be very complex and expensive and every effort must be made to design detectors which will have excellent performance and will not have to undergo major rebuilding. Some areas in which computer simulation is particularly needed are pattern recognition in tracking detectors and development of shower simulation code which can be trusted as an aid in the design and optimization of calorimeters, including their electron identification performance. Existing codes require too much computer time to be practical and need to be compared with test beam data at energies of several hundred GeV. Computer simulation of the processing of the data, including electronics response to the signals from the detector components, processing of the data by microprocessors on the detector, the trigger, and data acquisition will be required. In this report we discuss the detector simulation needs for detector designers.

  14. Differential affinity of mammalian histone H1 somatic subtypes for DNA and chromatin

    Directory of Open Access Journals (Sweden)

    Mora Xavier

    2007-05-01

    Full Text Available Abstract Background Histone H1 is involved in the formation and maintenance of chromatin higher order structure. H1 has multiple isoforms; the subtypes differ in timing of expression, extent of phosphorylation and turnover rate. In vertebrates, the amino acid substitution rates differ among subtypes by almost one order of magnitude, suggesting that each subtype might have acquired a unique function. We have devised a competitive assay to estimate the relative binding affinities of histone H1 mammalian somatic subtypes H1a-e and H1° for long chromatin fragments (30–35 nucleosomes in physiological salt (0.14 M NaCl at constant stoichiometry. Results The H1 complement of native chromatin was perturbed by adding an additional amount of one of the subtypes. A certain amount of SAR (scaffold-associated region DNA was present in the mixture to avoid precipitation of chromatin by excess H1. SAR DNA also provided a set of reference relative affinities, which were needed to estimate the relative affinities of the subtypes for chromatin from the distribution of the subtypes between the SAR and the chromatin. The amounts of chromatin, SAR and additional H1 were adjusted so as to keep the stoichiometry of perturbed chromatin similar to that of native chromatin. H1 molecules freely exchanged between the chromatin and SAR binding sites. In conditions of free exchange, H1a was the subtype of lowest affinity, H1b and H1c had intermediate affinities and H1d, H1e and H1° the highest affinities. Subtype affinities for chromatin differed by up to 19-fold. The relative affinities of the subtypes for chromatin were equivalent to those estimated for a SAR DNA fragment and a pUC19 fragment of similar length. Avian H5 had an affinity ~12-fold higher than H1e for both DNA and chromatin. Conclusion H1 subtypes freely exchange in vitro between chromatin binding sites in physiological salt (0.14 M NaCl. The large differences in relative affinity of the H1 subtypes for

  15. Prior infection with classical swine H1N1 influenza viruses is associated with protective immunity to the 2009 pandemic H1N1 virus.

    Science.gov (United States)

    Kash, John C; Qi, Li; Dugan, Vivien G; Jagger, Brett W; Hrabal, Rachel J; Memoli, Matthew J; Morens, David M; Taubenberger, Jeffery K

    2010-05-01

    The 2009 H1N1 pandemic emerged even though seasonal H1N1 viruses have circulated for decades. Epidemiological evidence suggested that the current seasonal vaccine did not offer significant protection from the novel pandemic, and that people over the age of 50 were less susceptible to infection. In a mouse challenge study with the 2009 pandemic H1N1 virus, we evaluated protective immune responses elicited by prior infection with human and swine influenza A viruses. Mice infected with A/Mexico/4108/2009 (Mex09) showed significant weight loss and 40% mortality. Prior infection with a 1976 classical swine H1N1 virus resulted in complete protection from Mex09 challenge. Prior infection with either a 2009 or a 1940 seasonal H1N1 influenza virus provided partial protection and a >100-fold reduction in viral lung titers at day 4 post-infection. These findings indicate that in experimental animals recently induced immunity to 1918-derived H1N1 seasonal influenza viruses, and to a 1976 swine influenza virus, afford a degree of protection against the 2009 pandemic virus. Implications of these findings are discussed in the context of accumulating data suggesting partial protection of older persons during the 2009 pandemic.

  16. Measurement of the longitudinal proton structure function in diffraction at the H1 experiment and prospects for diffraction at LHC

    Energy Technology Data Exchange (ETDEWEB)

    Salek, David

    2011-05-15

    A measurement of the longitudinal diffractive structure function F{sub L}{sup D} using the H1 detector at HERA is presented. The structure function is extracted from first measurements of the diffractive cross section ep{yields}eXY at centre of mass energies {radical}(s) of 225 and 252 GeV at high values of inelasticity y, together with a new measurement at {radical}(s) of 319 GeV, using data taken in 2006 and 2007. Previous H1 data at {radical}(s) of 301 GeV complete the kinematic coverage needed to extract F{sub L}{sup D} in the range of photon virtualities 2.57 GeV{sup 2} and compared to the analogous quantity for inclusive DIS. (orig.)

  17. The use of New Generation H1 Receptor Blockers and Advantages in Terms of Reliability

    Directory of Open Access Journals (Sweden)

    Muhammed Yayla

    2013-10-01

    Full Text Available H1 receptor blockers are one of the most commonly prescribed medications in the treatment of allergic disorders. These disease have reduced life quality of people and prevalent in the world. H1 receptor blockers has been used since 1940 and lead to some adverse effects such as sedation because of their chemical and pharmacological properties. Therefore new generations have been studied for reduced their adverse effect. The aims of this review are to exhibit advantages of new produced H1 receptor blockers compared to classical antihistamines and demonstrate efficacies of clinical uses of new produced H1 antihistamines. New generation H1 receptor blockers which have been developed after 1980s has less lipophilic properties and their sedative effects are minimized compared to classical antihistamines. Also, their specificity, affinity for H1 receptors and antihistaminergic effects are higher than classical H1 receptor blockers. Although new generation H1 receptor blockers are better tolerated than classical H1 receptor blockers, some of them lead to potential cardio toxicity. Consequently new generation H1 receptor blockers are reliable and efficient drugs, they provide convenience in the treatment of allergic disorders and prevent development of phobia against drugs.

  18. Linker histone H1 and H3K56 acetylation are antagonistic regulators of nucleosome dynamics.

    Science.gov (United States)

    Bernier, Morgan; Luo, Yi; Nwokelo, Kingsley C; Goodwin, Michelle; Dreher, Sarah J; Zhang, Pei; Parthun, Mark R; Fondufe-Mittendorf, Yvonne; Ottesen, Jennifer J; Poirier, Michael G

    2015-12-09

    H1 linker histones are highly abundant proteins that compact nucleosomes and chromatin to regulate DNA accessibility and transcription. However, the mechanisms that target H1 regulation to specific regions of eukaryotic genomes are unknown. Here we report fluorescence measurements of human H1 regulation of nucleosome dynamics and transcription factor (TF) binding within nucleosomes. H1 does not block TF binding, instead it suppresses nucleosome unwrapping to reduce DNA accessibility within H1-bound nucleosomes. We then investigated H1 regulation by H3K56 and H3K122 acetylation, two transcriptional activating histone post translational modifications (PTMs). Only H3K56 acetylation, which increases nucleosome unwrapping, abolishes H1.0 reduction of TF binding. These findings show that nucleosomes remain dynamic, while H1 is bound and H1 dissociation is not required for TF binding within the nucleosome. Furthermore, our H3K56 acetylation measurements suggest that a single-histone PTM can define regions of the genome that are not regulated by H1.

  19. Mitochondrial haplogroup H1 in north Africa: an early holocene arrival from Iberia.

    Directory of Open Access Journals (Sweden)

    Claudio Ottoni

    Full Text Available The Tuareg of the Fezzan region (Libya are characterized by an extremely high frequency (61% of haplogroup H1, a mitochondrial DNA (mtDNA haplogroup that is common in all Western European populations. To define how and when H1 spread from Europe to North Africa up to the Central Sahara, in Fezzan, we investigated the complete mitochondrial genomes of eleven Libyan Tuareg belonging to H1. Coalescence time estimates suggest an arrival of the European H1 mtDNAs at about 8,000-9,000 years ago, while phylogenetic analyses reveal three novel H1 branches, termed H1v, H1w and H1x, which appear to be specific for North African populations, but whose frequencies can be extremely different even in relatively close Tuareg villages. Overall, these findings support the scenario of an arrival of haplogroup H1 in North Africa from Iberia at the beginning of the Holocene, as a consequence of the improvement in climate conditions after the Younger Dryas cold snap, followed by in situ formation of local H1 sub-haplogroups. This process of autochthonous differentiation continues in the Libyan Tuareg who, probably due to isolation and recent founder events, are characterized by village-specific maternal mtDNA lineages.

  20. Genetic correlation between current circulating H1N1 swine and human influenza viruses.

    Science.gov (United States)

    Lu, Lu; Yin, Yanbo; Sun, Zhongsheng; Gao, Lei; Gao, George F; Liu, Sidang; Sun, Lei; Liu, Wenjun

    2010-11-01

    H1N1 is the main subtype influenza A virus circulating in human and swine population, and has long been a threat to economy and public health. To explore the genetic correlation between current circulating H1N1 swine and human influenza viruses. Three new H1N1 swine influenza viruses (SIVs) were isolated and genomes sequencing were conducted followed by phylogenetic and molecular analysis of all swine and human H1N1 influenza viruses isolated in China in the past five years. Homology and phylogenetic analysis revealed that the three isolates possessed different characteristics: the genome of A/Swine/Shandong/1112/2008 was closely related to that of classical H1N1 SIV, while A/Swine/Shandong/1123/2008 was a reassortant with NS gene from the human-like H3N2 influenza virus and other genes from the classical H1N1 SIV, and A/Swine/Fujian/0325/2008 fell into a lineage of seasonal human H1N1 influenza viruses. Genetically, 2009 H1N1 influenza A viruses (2009 H1N1) in China were contiguous to the SIV lineages rather than the seasonal H1N1 human influenza virus's lineage. Furthermore, molecular analysis among human and swine influenza viruses provided more detail information for understanding their genetic correlation. These results suggested that in China in the past five years, the classical, avian-like and human-like H1N1 SIV existed in swine herds and the reassortment between H1N1 swine and H3N2 human influenza viruses was identified. In addition, the present data showed no evidence to support a strong correlation between the 2009 H1N1 and the swine influenza virus circulating in China. Copyright © 2010 Elsevier B.V. All rights reserved.

  1. 25. L’exobiologie ou la recherche de vie extraterrestre

    OpenAIRE

    Brack, André

    2017-01-01

    Sommes-nous seuls ? Y a-t-il une vie ailleurs dans l’Univers ? Ces questions sont au cœur de l’exobiologie, plus connue à l’étranger sous le nom d’astrobiologie, science qui étudie l’origine, la distribution et l’évolution de la vie dans l’Univers. Ce vaste domaine pluridisciplinaire de recherche fait appel aux sciences de l’Univers, aux sciences de la Terre, la physique, la chimie, la biologie ainsi qu’à des sciences sociales comme la sociologie et l’épistémologie. Cette recherche se double ...

  2. Centre de recherche des énergies renouvelables

    OpenAIRE

    NEMICHE, Youssouf; AZZOUT, Sarah

    2013-01-01

    Dans ce cadre le pole de recherche sur les énergies renouvelables que nous avons étudiées dans la ville de Tlemcen marquera une ère de développement dans la recherche des énergies renouvelables. Nous savons tous : Architectes, Ingénieurs, Paysages, écologistes et autres très bien aujourd’hui que les solutions existent, nous avons tous le pouvoir de changer alors qu’est ce qu’on attend.

  3. Panblok-H1+advax H1N1/2009pdm vaccine: Insights into rapid development of a delta inulin adjuvanted recombinant pandemic influenza vaccine.

    Science.gov (United States)

    Honda-Okubo, Yoshikazu; Rajapaksha, Harinda; Sajkov, Dimitar; Gordon, David; Cox, Manon M J; Petrovsky, Nikolai

    2017-06-03

    Timely vaccine supply is critical during influenza pandemics but is impeded by current virus-based manufacturing methods. The 2009 H1N1/2009pdm 'swine flu' pandemic reinforced the need for innovation in pandemic vaccine design. We report on insights gained during rapid development of a pandemic vaccine based on recombinant haemagglutinin (rHA) formulated with Advax™ delta inulin adjuvant (Panblok-H1/Advax). Panblok-H1/Advax was designed and manufactured within 1 month of the pandemic declaration by WHO and successfully entered human clinical testing in under 3 months from first isolation and sequencing of the novel pandemic virus, requiring several major challenges to be overcome. Panblok-H1/Advax successfully induced neutralising antibodies against the pandemic strain, but also induced cross-neutralising antibodies in a subset of subjects against an H1N1 strain (A/Puerto Rico/8/34) derived from the 1918 Spanish flu, highlighting the possibility to use Advax to induce more broadly cross-protective antibody responses. Interestingly, the rHA from H1N1/2009pdm exhibited variants in the receptor binding domain that had a major impact on receptor binding and hemagglutination ability. We used an in silico structural modeling approach to better understand the unusual behavior of the novel hemagglutinin, thereby demonstrating the power of computational modeling approaches for rapid characterization of new pandemic viruses. While challenges remain in ensuring ultrafast vaccine access for the entire population in response to future pandemics, the adjuvanted recombinant Panblok-H1/Advax vaccine proved its utility during a real-life pandemic situation.

  4. Reasons for Low Pandemic H1N1 2009 Vaccine Acceptance within a College Sample

    Directory of Open Access Journals (Sweden)

    Russell D. Ravert

    2012-01-01

    Full Text Available This study examined health beliefs associated with novel influenza A (H1N1 immunization among US college undergraduates during the 2009-2010 pandemic. Undergraduates (ages 18–24 years from a large Midwestern University were invited to complete an online survey during March, 2010, five months after H1N1 vaccines became available. Survey items measured H1N1 vaccine history and H1N1-related attitudes based on the health belief literature. Logistic regression was used to identify attitudes associated with having received an H1N1 vaccine, and thematic analysis of student comments was conducted to further understand influences on vaccine decisions. Among the 296 students who participated in the survey, 15.2% reported having received an H1N1 vaccine. In regression analysis, H1N1 immunization was associated with seasonal flu vaccine history, perceived vaccine effectiveness, perceived obstacles to vaccination, and vaccine safety concerns. Qualitative results illustrate the relationship of beliefs to vaccine decisions, particularly in demonstrating that students often held concerns that vaccine could cause H1N1 or side effects. Vaccine safety, efficacy, and obstacles to immunization were major considerations in deciding whether to accept the H1N1 pandemic vaccine. Therefore, focusing on those aspects might be especially useful in future vaccine efforts within the college population.

  5. Novel Influenza A (H1N1)-Associated Acute Necrotizing Encephalopathy: A Case Report

    OpenAIRE

    Kim, Ki Jung; Park, Eun Sook; Chang, Hyun Jung; Suh, Miri; Rha, Dong-Wook

    2013-01-01

    Several cases of acute necrotizing encephalopathy (ANE) with influenza A (H1N1) have been reported to date. The prognosis of ANE associated with H1N1 is variable; some cases resulted in severe neurologic complication, whereas other cases were fatal. Reports mostly focused on the diagnosis of ANE with H1N1 infection, rather than functional recovery. We report a case of ANE with H1N1 infection in a 4-year-old Korean girl who rapidly developed fever, seizure, and altered mentality, as well as ha...

  6. Prior infection of chickens with H1N1 or H1N2 avian influenza elicits partial heterologous protection against highly pathogenic H5N1.

    Directory of Open Access Journals (Sweden)

    Charles Nfon

    Full Text Available There is a critical need to have vaccines that can protect against emerging pandemic influenza viruses. Commonly used influenza vaccines are killed whole virus that protect against homologous and not heterologous virus. Using chickens we have explored the possibility of using live low pathogenic avian influenza (LPAI A/goose/AB/223/2005 H1N1 or A/WBS/MB/325/2006 H1N2 to induce immunity against heterologous highly pathogenic avian influenza (HPAI A/chicken/Vietnam/14/2005 H5N1. H1N1 and H1N2 replicated in chickens but did not cause clinical disease. Following infection, chickens developed nucleoprotein and H1 specific antibodies, and reduced H5N1 plaque size in vitro in the absence of H5 neutralizing antibodies at 21 days post infection (DPI. In addition, heterologous cell mediated immunity (CMI was demonstrated by antigen-specific proliferation and IFN-γ secretion in PBMCs re-stimulated with H5N1 antigen. Following H5N1 challenge of both pre-infected and naïve controls chickens housed together, all naïve chickens developed acute disease and died while H1N1 or H1N2 pre-infected chickens had reduced clinical disease and 70-80% survived. H1N1 or H1N2 pre-infected chickens were also challenged with H5N1 and naïve chickens placed in the same room one day later. All pre-infected birds were protected from H5N1 challenge but shed infectious virus to naïve contact chickens. However, disease onset, severity and mortality was reduced and delayed in the naïve contacts compared to directly inoculated naïve controls. These results indicate that prior infection with LPAI virus can generate heterologous protection against HPAI H5N1 in the absence of specific H5 antibody.

  7. GADRAS Detector Response Function.

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Dean J.; Harding, Lee; Thoreson, Gregory G; Horne, Steven M.

    2014-11-01

    The Gamma Detector Response and Analysis Software (GADRAS) applies a Detector Response Function (DRF) to compute the output of gamma-ray and neutron detectors when they are exposed to radiation sources. The DRF is fundamental to the ability to perform forward calculations (i.e., computation of the response of a detector to a known source), as well as the ability to analyze spectra to deduce the types and quantities of radioactive material to which the detectors are exposed. This document describes how gamma-ray spectra are computed and the significance of response function parameters that define characteristics of particular detectors.

  8. Monitoring peanut allergen in food products by measuring Ara h 1.

    Science.gov (United States)

    Pomés, Anna; Helm, Ricki M; Bannon, Gary A; Burks, A Wesley; Tsay, Amy; Chapman, Martin D

    2003-03-01

    Peanut allergy is an important health problem in the United States, affecting approximately 0.6% of children. Inadvertent exposure to peanut is a risk factor for life-threatening food-induced anaphylaxis. The purpose of this investigation was to develop an immunoassay for a major peanut allergen, Ara h 1, to detect peanut allergen in foods so that the risk of inadvertent exposure can be reduced. A specific 2-site monoclonal antibody-based ELISA was developed to measure Ara h 1 in foods. The sensitivity of the assay was 30 ng/mL. Ara h 1 was measured in foods (n = 83) with or without peanut and in experiments to optimize allergen yield and to determine peanut contamination in spiked foods. Ara h 1 levels in food products ranged from less than 0.1 microg/g to 500 microg/g. Ara h 1 measured in ng/mL was transformed to microg/g for food products. Peanut butter contained the highest amounts of Ara h 1. Peanut extracts contained from 0.5 to 15 mg Ara h 1/g of peanut depending on the extraction conditions. Optimal extraction of Ara h 1 was obtained by using phosphate buffer with 1 mol/L NaCl and Tween at 60 degrees C. Ara h 1 was not always detected in presence of chocolate under the extraction conditions tested. Spiking experiments showed that the assay could detect approximately 0.1% Ara h 1 contamination of food with ground peanut. There was an excellent correlation between Ara h 1 levels and peanut content measured by using a commercial polyclonal antibody-based ELISA (r = 93, n = 31, P allergy.

  9. Functional pharmacology of H1 histamine receptors expressed in mouse preoptic/anterior hypothalamic neurons

    Science.gov (United States)

    Tabarean, I V

    2013-01-01

    BACKGROUND AND PURPOSE Histamine H1 receptors are highly expressed in hypothalamic neurons and mediate histaminergic modulation of several brain-controlled physiological functions, such as sleep, feeding and thermoregulation. In spite of the fact that the mouse is used as an experimental model for studying histaminergic signalling, the pharmacological characteristics of mouse H1 receptors have not been studied. In particular, selective and potent H1 receptor agonists have not been identified. EXPERIMENTAL APPROACH Ca2+ imaging using fura-2 fluorescence signals and whole-cell patch-clamp recordings were carried out in mouse preoptic/anterior hypothalamic neurons in culture. KEY RESULTS The H1 receptor antagonists mepyramine and trans-triprolidine potently antagonized the activation by histamine of these receptors with IC50 values of 0.02 and 0.2 μM respectively. All H1 receptor agonists studied had relatively low potency at the H1 receptors expressed by these neurons. Methylhistaprodifen and 2-(3-trifluoromethylphenyl)histamine had full-agonist activity with potencies similar to that of histamine. In contrast, 2-pyridylethylamine and betahistine showed only partial agonist activity and lower potency than histamine. The histamine receptor agonist, 6-[2-(4-imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptanecarboxamide (HTMT) had no agonist activity at the H1 receptors H1 receptors expressed by mouse preoptic/anterior hypothalamic neurons but displayed antagonist activity. CONCLUSIONS AND IMPLICATIONS Methylhistaprodifen and 2-(3-trifluoromethylphenyl)histamine were identified as full agonists of mouse H1 receptors. These results also indicated that histamine H1 receptors in mice exhibited a pharmacological profile in terms of agonism, significantly different from those of H1 receptors expressed in other species. PMID:23808378

  10. Livres | Page 35 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Nous sommes déterminés à améliorer les conditions de vie et les moyens de subsistance en appuyant la recherche sur des questions essentielles de développement international. Les publications du CRDI et des chercheurs que nous subventionnons constituent un important moyen de susciter des changements positifs.

  11. Publications | Page 102 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'action du CRDI L'adaptation aux changements climatiques. De nouvelles connaissances pour un avenir incertain. Bien avant que l'expression « réchauffement de la planète » ne fasse la manchette, le Centre de recherches pour le développement international (CRDI), organisme.

  12. Publications | Page 101 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'action du CRDI L'adaptation aux changements climatiques. De nouvelles connaissances pour un avenir incertain. Bien avant que l'expression « réchauffement de la planète » ne fasse la manchette, le Centre de recherches pour le développement international (CRDI), organisme.

  13. Inde | Page 87 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Langue English. LA QUÊTE DE CONNAISSANCES ET LE RENFORCEMENT DES CAPACITÉS. Le CRDI appuyait la recherche sur l'adaptation des humains à la variabilité et aux changements climatiques bien avant que l'expression « réchauffement de la planète » ne vienne dominer les manchettes à l'échelle mondiale.

  14. Une vive concurrence | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    universitaires chevronnés de renom, font oeuvre de pionniers en ouvrant de nouvelles voies à la recherche appliquée sur la pauvreté et les inégalités en Chine. Le Young China Scholars Poverty Research Network est le résultat d'une collaboration ...

  15. Publications | Page 223 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  16. Publications | Page 227 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... au Togo" (open access). Le projet Savoirs locaux et gestion de la biodiversité : Habitudes alimentaires et utilisation des plantes alimentaires mineures ou menacées de disparition au Togo est financé par le Centre de Recherche et de Développement International (CRDI) et exécuté par le Laboratoire de Botanique et.

  17. Publications | Page 88 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    African Education Development Issues - Journées de la Recherche en Education en Côte d'Ivoire (restricted access). The aim of this analysis is to show the importance of materials in a teaching and learning situation. This analysis explains how successful learning is when it is sustained by documents. It also sheds lights on ...

  18. Publications | Page 158 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  19. Publications | Page 138 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  20. canada : tous les projets | Page 21 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Sujet: SRI LANKA, REMITTANCES, PEACE, TERRORISM, CONFLICT RESOLUTION, COMMUNITY DEVELOPMENT. Région: Canada, North and Central America, Sri Lanka, South America, Central Asia, Far East Asia, South Asia. Programme: Gouvernance et justice. Financement total : CA$ 366,700.00. Recherche ...

  1. Droits d'auteur | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Droits d'auteur détenus par le CRDI Sauf indication contraire, les droits d'auteur relatifs aux documents mis en ligne sur le présent site Web sont détenus par le Centre de recherches pour le développement international (CRDI).

  2. Cambodia : tous les projets | Page 3 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    SEATCA) de coordonner un programme de recherche pour appuyer la mise en oeuvre (dans le cas du Cambodge) et la ratification (dans le cas du Laos) de la Convention-cadre pour la lutte antitabac (CCLAT) de l'Organisation mondiale de la santé.

  3. canada : tous les projets | Page 19 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Sujet: International cooperation, ORGANIZATIONAL CHANGE. Région: Canada. Programme: Fondements pour l'innovation. Financement total : CA$ 609,600.00. Faire en sorte que la recherche en santé influence les politiques. Projet. Le fait que les taux de mortalité et de morbidité demeurent élevés dans de nombreux ...

  4. Livres | Page 8 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Nous sommes déterminés à améliorer les conditions de vie et les moyens de subsistance en appuyant la recherche sur des questions essentielles de développement international. Les publications du CRDI et des chercheurs que nous subventionnons constituent un important moyen de susciter des changements positifs.

  5. Publications | Page 182 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  6. Questionnement sur les liens de la recherche avec les autres ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    enseignement, la recherche et les services à la société. Malgré les ressources et les efforts consentis par les pays africains et leurs partenaires, l'accomplissement de ces missions par l'institution universitaire semble plutôt mitigé.

  7. Livres | Page 33 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Nous sommes déterminés à améliorer les conditions de vie et les moyens de subsistance en appuyant la recherche sur des questions essentielles de développement international. Les publications du CRDI et des chercheurs que nous subventionnons constituent un important moyen de susciter des changements positifs.

  8. Publications | Page 172 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    E-Commerce in the Asian Context : Selected Case Studies. Le commerce électronique en Asie retient beaucoup l'attention en raison de la prolifération des connexions Internet et des technologies connexes dans la région. Face à cette tendance, le Centre de recherches pour le développement international (.

  9. Publications | Page 173 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    E-Commerce in the Asian Context : Selected Case Studies. Le commerce électronique en Asie retient beaucoup l'attention en raison de la prolifération des connexions Internet et des technologies connexes dans la région. Face à cette tendance, le Centre de recherches pour le développement international (.

  10. Renforcement du dialogue entre acteurs de la recherche agricole et ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Participation des pays en développement au Projet international de code barre du vivant. Le code barre ADN est un nouvel outil de recherche taxinomique. Voir davantageParticipation des pays en développement au Projet international de code barre du vivant ...

  11. canada : tous les projets | Page 15 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le code barre ADN est un nouvel outil de recherche taxinomique. Date de début : 1 avril 2010. End Date: 1 octobre 2013. Sujet: BIOLOGY, BIODIVERSITY, ECOLOGY. Région: Argentina, South America, Costa Rica, North and Central America, Kenya, Peru, South Africa, North of Sahara, South of Sahara, Mexico, Canada.

  12. Mexico : tous les projets | Page 4 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le code barre ADN est un nouvel outil de recherche taxinomique. Date de début : 1 avril 2010. End Date: 1 octobre 2013. Sujet: BIOLOGY, BIODIVERSITY, ECOLOGY. Région: Argentina, South America, Costa Rica, North and Central America, Kenya, Peru, South Africa, North of Sahara, South of Sahara, Mexico, Canada.

  13. Publications | Page 81 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  14. Publications | Page 232 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  15. Livres | Page 29 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Nous sommes déterminés à améliorer les conditions de vie et les moyens de subsistance en appuyant la recherche sur des questions essentielles de développement international. Les publications du CRDI et des chercheurs que nous subventionnons constituent un important moyen de susciter des changements positifs.

  16. Livres | Page 14 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Nous sommes déterminés à améliorer les conditions de vie et les moyens de subsistance en appuyant la recherche sur des questions essentielles de développement international. Les publications du CRDI et des chercheurs que nous subventionnons constituent un important moyen de susciter des changements positifs.

  17. Publications | Page 91 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  18. Publications | Page 123 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  19. Publications | Page 189 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  20. Livres | Page 30 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Nous sommes déterminés à améliorer les conditions de vie et les moyens de subsistance en appuyant la recherche sur des questions essentielles de développement international. Les publications du CRDI et des chercheurs que nous subventionnons constituent un important moyen de susciter des changements positifs.

  1. Publications | Page 90 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  2. Projet pilote pour le programme national de recherche et de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'idée d'un programme national de recherche et de formation (PRIDE en espagnol) est issue du projet Mise en place de systèmes d'apprentissage au Honduras (projet 100133), soutenu par le CRDI. La subvention est accordée pour appuyer une version pilote de PRIDE, reposant sur deux appels à propositions.

  3. Asie centrale | Page 64 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Read more about Toward Détente in Media Piracy. Langue English. Read more about Recherche d'une détente dans le dossier du piratage des médias. Langue French. Read more about ONI-Asia - censure et surveillance numériques. Langue French. Read more about OpenNet Initiative - Asia : Digital Censorship and ...

  4. Livres | Page 22 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Nous sommes déterminés à améliorer les conditions de vie et les moyens de subsistance en appuyant la recherche sur des questions essentielles de développement international. Les publications du CRDI et des chercheurs que nous subventionnons constituent un important moyen de susciter des changements positifs.

  5. Publications | Page 38 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Amérique du Nord et de l'Europe pour inclure maintenant un plus grand nombre d'établissements de recherche africains. Activité antérieure : Le CRDI au Congrès mondial sur la santé publique 2015. Le 14e Congrès mondial sur la santé publique ...

  6. Chile : tous les projets | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les femmes appuyant les femmes » est un projet de recherche appliquée dirigé par la Fundación Democracia y Desarrollo. Région: Chile, Latin America. Programme: Governance and Justice. Financement total : CA$ 356,500.00. Adaptation aux changements climatiques dans les établissements informels : Comprendre et ...

  7. Kenya | Page 53 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le Centre de recherches pour le développement international (CRDI), organisme canadien, a joué un rôle de premier plan dans l'émergence de cette nouvelle ... In issue 25 of Urban Agriculture Magazine – RUAF 10 years, IDRC program officer and urban agriculture specialist Luc Mougeot traces the achievements of this ...

  8. Publications | Page 178 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  9. Publications | Page 77 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  10. Publications | Page 79 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  11. Child Soldiers Initiative | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    A number of militaries, human rights organizations, humanitarian groups, and peace and security actors have been grappling with the issue for some time, acting ... L'honorable Chrystia Freeland, ministre du Commerce international, a annoncé le lancement d'un nouveau projet financé par le Centre de recherches pour le ...

  12. Publications | Page 46 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La modélisation mathématique éclaire les politiques de prévention du VIH en Chine. Un projet de recherche financé par le CRDI utilise la modélisation mathématique pour influer sur les politiques locales et nationales de réduction de la transmission du VIH en Chine.

  13. Livres | Page 12 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Nous sommes déterminés à améliorer les conditions de vie et les moyens de subsistance en appuyant la recherche sur des questions essentielles de développement international. Les publications du CRDI et des chercheurs que nous subventionnons constituent un important moyen de susciter des changements positifs.

  14. Publications | Page 43 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Institut national de la recherche agronomique du Niger (INRAN) est un établissement public à caractère scientifique, culturel et technique qui a pour mission de favoriser la sécurité alimentaire et le développement rural par le truchement de la ...

  15. Asie centrale | Page 36 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Langue French. Read more about Learning from Low Income Market-driven Innovations and Social Entrepreneurship in India. Langue English. Read more about Institutional Support to South Asian Policy Research Organizations. Langue English. Read more about Soutien institutionnel à des organismes de recherche sur ...

  16. Publications | Page 183 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  17. Publications | Page 165 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  18. cambodia : tous les projets | Page 4 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Sujet: TRANSPORT INFRASTRUCTURE, INTERNATIONAL TRANSPORT, REGIONAL INTEGRATION, TRADE FACILITATION. Région: Central Asia, Far East Asia, South Asia, Cambodia, China, Laos, Viet Nam, Thailand. Programme: Emploi et croissance. Financement total : CA$ 300,000.00. Programme de recherche sur ...

  19. Initiative de recherche internationale sur l'adaptation aux ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    C'est ce manque de connaissances que l'Initiative de recherche internationale sur l'adaptation aux changements climatiques (IRIACC) vise à combler en ... urgent relié aux changements climatiques et s'efforcent de trouver des solutions et des stratégies qui aideront les collectivités à composer avec la variabilité du climat.

  20. La recherche-action participative facilite l'adaptation aux ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    15 mai 2012 ... Les travaux de recherche menés dans le cadre du programme Adaptation aux changements climatiques en Afrique (ACCA) ont exploré des moyens d'améliorer la capacité des pays ... Impacts of climate change and variability, and adaptation strategies on agriculture in semi-arid areas of Tanzania.

  1. Publications | Page 64 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  2. initiative des conseils subventionnaires de la recherche scientifique ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Dorine Odongo

    INITIATIVE DES CONSEILS SUBVENTIONNAIRES DE LA RECHERCHE SCIENTIFIQUE EN. AFRIQUE SUBSAHARIENNE. MANIFESTATION D'INTÉRÊT. 1. Pays et organisme partenaire. 1.1 Pays. 1.2 Nom de l'organisme partenaire. 1.3 Dirigeant de l'organisme partenaire. 1.4 Affiliation au ministère gouvernemental.

  3. Recherche sur l'adaptation aux changements climatiques

    International Development Research Centre (IDRC) Digital Library (Canada)

    Corey Piccioni

    adaptation aux changements climatiques. Le CRDI est un bailleur de fonds essentiel et un pionnier de la recherche sur l'adaptation aux changements clima- tiques dans les pays en développement. Le Centre a géré un budget de programmes ...

  4. Livres | Page 26 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Nous sommes déterminés à améliorer les conditions de vie et les moyens de subsistance en appuyant la recherche sur des questions essentielles de développement international. Les publications du CRDI et des chercheurs que nous subventionnons constituent un important moyen de susciter des changements positifs.

  5. Pakistan : Semer autrement | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    5 mai 2016 ... L'année suivante, à peine relevés, les Pakistanais faisaient face à une autre inondation majeure dans la zone semi-aride de Sindh. ... de recherche au Pakistan, avec la Lahore University of Management Sciences(LUMS), afin de comprendre comment les agriculteurs peuvent s'adapter aux aléas du climat.

  6. Senegal : tous les projets | Page 4 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    WAPHIR) : plateforme de recherche interventionnelle en matière de VIH en Afrique de l'Ouest. Projet. Grâce à cette subvention, ... Sujet: TOBACCO, SMOKING, PUBLIC HEALTH, LEGISLATION. Région: Senegal, North of Sahara, South of Sahara.

  7. Publications | Page 229 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  8. Initiative Think tank | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'ITT est le fruit d'un partenariat regroupant cinq bailleurs de fonds. Lancée en 2008, l'ITT est administrée par le Centre de Recherches pour le Développement International (CRDI), un organisme canadien.

  9. Abonnez-vous | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    vous · Carrières · Communiquez avec nous · Désabonnez-vous · Plan du site. Suivez-nous; Facebook · Twitter · Youtube · Linked In · RSS Feed · Droits d'auteur · Éthique de la recherche · Politique de libre accès · Politique de confidentialité ...

  10. Recherche d'autoanticorps antierythrocytaires chez des insuffisants ...

    African Journals Online (AJOL)

    This antibodies could induce an autoimmune hemolytic anemia. Les auteurs rapportent les résultats de la recherche d'autoanticorps antiérythrocytaires qui pourraient participer au mécanisme de l'anémie normochrome normocytaire que présentent constamment les insuffisants rénaux chroniques. Cette étude a inclus 75 ...

  11. Canada : tous les projets | Page 11 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La faculté de droit de l'Université de New York, avec le soutien du CRDI, a créé un projet de recherche concertée sur le droit administratif international (Global Administrative Law [GAL] Project) dans le but de faire en sorte que les universitaires, chercheurs, scientifiques, avocats, fonctionnaires, ONG et entreprises des pays ...

  12. Tunisie : tous les projets | Page 2 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Participation des jeunes femmes à la vie politique en Tunisie : mobilisation institutionnelle et non structurée. Projet. Le programme Droits des femmes et participation citoyenne (DFPC) du CRDI appuie un ensemble de recherches comparatives visant à déterminer si les institutions de démocratie et de gouvernance tiennent ...

  13. Publications | Page 80 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  14. Livres | Page 9 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Nous sommes déterminés à améliorer les conditions de vie et les moyens de subsistance en appuyant la recherche sur des questions essentielles de développement international. Les publications du CRDI et des chercheurs que nous subventionnons constituent un important moyen de susciter des changements positifs.

  15. Livres | Page 2 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Nous sommes déterminés à améliorer les conditions de vie et les moyens de subsistance en appuyant la recherche sur des questions essentielles de développement international. Les publications du CRDI et des chercheurs que nous subventionnons constituent un important moyen de susciter des changements positifs.

  16. Kenya | Page 39 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Read more about Research on Business Process Outsourcing. Langue English. Read more about Recherche sur l'impartition des processus administratifs. Langue French. Read more about Integrated Water, Sanitation and Solid Waste Management in Small Urban Centres around Lake Victoria (Kenya). Langue English.

  17. Publications | Page 206 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  18. Changements climatiques | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Read more about Bâtir un monde climato-intelligent. Langue French. Read more about Renforcement des capacités en économie de l'environnement dans la recherche sur l'adaptation aux changements climatiques. Langue French. Read more about Renforcement des connaissances économiques et de la capacité ...

  19. Perspectives | Page 3 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    autonomisation économique des femmes en janvier 2016 a permis aux think tanks et à d'autres établissements de recherche d'échanger des données probantes sur les facteurs qui permettent d'accroître l'entrepreneuriat féminin. Date de publication: 22 ...

  20. Publications | Page 4 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  1. Publications | Page 94 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  2. Publications | Page 96 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  3. Publications | Page 132 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  4. Publications | Page 112 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  5. Publications | Page 233 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  6. Publications | Page 26 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  7. Publications | Page 137 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  8. Publications | Page 111 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  9. Publications | Page 11 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  10. Publications | Page 192 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  11. Publications | Page 200 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  12. Publications | Page 222 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  13. Publications | Page 52 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  14. Publications | Page 40 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  15. Publications | Page 216 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  16. Publications | Page 6 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  17. Publications | Page 16 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  18. Publications | Page 3 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  19. Publications | Page 194 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  20. Publications | Page 220 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  1. Publications | Page 83 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  2. Publications | Page 228 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  3. Publications | Page 215 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  4. Publications | Page 35 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  5. Publications | Page 221 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  6. Publications | Page 84 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  7. Publications | Page 100 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  8. Publications | Page 104 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  9. Publications | Page 15 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  10. Publications | Page 127 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  11. Publications | Page 7 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  12. Publications | Page 145 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  13. Publications | Page 196 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  14. Publications | Page 213 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  15. Publications | Page 92 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  16. Publications | Page 135 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  17. Publications | Page 8 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  18. Publications | Page 108 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  19. Publications | Page 230 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  20. Publications | Page 131 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  1. Publications | Page 226 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  2. Publications | Page 13 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  3. Publications | Page 119 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  4. Publications | Page 191 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  5. Publications | Page 218 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  6. Publications | Page 199 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  7. Publications | Page 95 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  8. Publications | Page 219 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  9. Publications | Page 18 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  10. Publications | Page 225 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  11. Publications | Page 12 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  12. Publications | Page 133 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  13. Publications | Page 25 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  14. Publications | Page 224 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  15. Publications | Page 234 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  16. Publications | Page 113 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  17. Publications | Page 231 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  18. Publications | Page 134 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  19. Publications | Page 205 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  20. Publications | Page 50 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  1. Publications | Page 195 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  2. Publications | Page 87 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  3. Publications | Page 73 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  4. Publications | Page 101 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  5. Publications | Page 122 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  6. Publications | Page 85 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  7. Publications | Page 136 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  8. Publications | Page 78 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  9. Publications | Page 32 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  10. Publications | Page 98 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  11. Publications | Page 106 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  12. Publications | Page 197 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  13. Publications | Page 109 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  14. Publications | Page 214 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  15. Publications | Page 20 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  16. Publications | Page 62 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  17. Publications | Page 61 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  18. African Tobacco Situation Analyses | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Subventions destinées à l'élaboration de propositions dans le cadre de l'initiative Analyses situationnelles sur le tabagisme en Afrique. Le programme Recherche pour la lutte mondiale contre le tabac (RMCT) du CRDI collabore avec la Fondation Bill et Melinda Gates dans le cadre de l'initiative Analyses situationnelles sur ...

  19. Publications | Page 155 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  20. Publications | Page 37 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  1. Livres | Page 28 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Nous sommes déterminés à améliorer les conditions de vie et les moyens de subsistance en appuyant la recherche sur des questions essentielles de développement international. Les publications du CRDI et des chercheurs que nous subventionnons constituent un important moyen de susciter des changements positifs.

  2. Emploi et croissance | Page 13 | CRDI - Centre de recherches pour ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Langue French. Read more about VIH/sida, mondialisation et vulnérabilité. Langue French. Read more about Réseau de recherche économique du Vietnam (VERN) - phase II. Langue French. Read more about Modernisation des marchés agroalimentaires - inclusion des petits exploitants aux marchés dynamiques.

  3. Emploi et croissance | Page 17 | CRDI - Centre de recherches pour ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Emploi et croissance. Langue French. Read more about VIH/sida, mondialisation et vulnérabilité. Langue French. Read more about Trade and Industrial Policy Strategies (TIPS) - phase III. Langue French. Read more about Réseau de recherche économique du Vietnam (VERN) - phase II. Langue French. Read more about ...

  4. Charm and beauty production in D{sup *}{mu} events at H1/HERA

    Energy Technology Data Exchange (ETDEWEB)

    Lucaci-Timoce, A.I.

    2007-07-15

    Charm and beauty photoproduction is investigated with the H1 detector at HERA using events with a reconstructed D{sup *} meson and a muon. Data taken during the years 1999-2000 and 2004-2006, corresponding to a total integrated luminosity of 320 pb{sup -1}, are analysed. The D{sup *} mesons with transverse momentum p{sub t}(D{sup *})>1.5 GeV and pseudorapidity vertical stroke {eta}(D{sup *}) vertical stroke <1.5 are reconstructed via the decay channel D{sup *{+-}}{yields}D{sup (-)0}{pi}{sub s}{sup {+-}}{yields}(K{sup -+}{pi}{sup {+-}}){pi}{sub s}{sup {+-}}. In addition, muons with momentum p({mu})>2 GeV and vertical stroke {eta}({mu}) vertical stroke <1.735 are selected. With this selection, the contribution of light quark initiated events is negligible. The fractions of charm and beauty events in data are extracted exploiting the charge and azimuthal angle correlation between the D{sup *} meson and the muon. The charm and beauty cross sections were measured in photoproduction, i.e. for photon virtualities Q{sup 2}<1 GeV{sup 2}, and for inelasticities 0.05

  5. Supply of neuraminidase inhibitors related to reduced influenza A (H1N1 mortality during the 2009-2010 H1N1 pandemic: an ecological study.

    Directory of Open Access Journals (Sweden)

    Paula E Miller

    Full Text Available BACKGROUND: The influenza A (H1N1 pandemic swept across the globe from April 2009 to August 2010 affecting millions. Many WHO Member States relied on antiviral drugs, specifically neuraminidase inhibitors (NAIs oseltamivir and zanamivir, to treat influenza patients in critical condition. Such drugs have been found to be effective in reducing severity and duration of influenza illness, and likely reduced morbidity during the pandemic. However, it is less clear whether NAIs used during the pandemic reduced H1N1 mortality. METHODS: Country-level data on supply of oseltamivir and zanamivir were used to predict H1N1 mortality (per 100,000 people from July 2009 to August 2010 in forty-two WHO Member States. Poisson regression was used to model the association between NAI supply and H1N1 mortality, with adjustment for economic, demographic, and health-related confounders. RESULTS: After adjustment for potential confounders, each 10% increase in kilograms of oseltamivir, per 100,000 people, was associated with a 1.6% reduction in H1N1 mortality over the pandemic period (relative rate (RR = 0.84 per log increase in oseltamivir supply. While the supply of zanamivir was considerably less than that of oseltamivir in each Member State, each 10% increase in kilogram of active zanamivir, per 100,000, was associated with a 0.3% reduction in H1N1 mortality (RR = 0.97 per log increase. CONCLUSION: While there are limitations to the ecologic nature of these data, this analysis offers evidence of a protective relationship between antiviral drug supply and influenza mortality and supports a role for influenza antiviral use in future pandemics.

  6. Supply of neuraminidase inhibitors related to reduced influenza A (H1N1) mortality during the 2009-2010 H1N1 pandemic: an ecological study.

    Science.gov (United States)

    Miller, Paula E; Rambachan, Aksharananda; Hubbard, Roderick J; Li, Jiabai; Meyer, Alison E; Stephens, Peter; Mounts, Anthony W; Rolfes, Melissa A; Penn, Charles R

    2012-01-01

    The influenza A (H1N1) pandemic swept across the globe from April 2009 to August 2010 affecting millions. Many WHO Member States relied on antiviral drugs, specifically neuraminidase inhibitors (NAIs) oseltamivir and zanamivir, to treat influenza patients in critical condition. Such drugs have been found to be effective in reducing severity and duration of influenza illness, and likely reduced morbidity during the pandemic. However, it is less clear whether NAIs used during the pandemic reduced H1N1 mortality. Country-level data on supply of oseltamivir and zanamivir were used to predict H1N1 mortality (per 100,000 people) from July 2009 to August 2010 in forty-two WHO Member States. Poisson regression was used to model the association between NAI supply and H1N1 mortality, with adjustment for economic, demographic, and health-related confounders. After adjustment for potential confounders, each 10% increase in kilograms of oseltamivir, per 100,000 people, was associated with a 1.6% reduction in H1N1 mortality over the pandemic period (relative rate (RR) = 0.84 per log increase in oseltamivir supply). While the supply of zanamivir was considerably less than that of oseltamivir in each Member State, each 10% increase in kilogram of active zanamivir, per 100,000, was associated with a 0.3% reduction in H1N1 mortality (RR = 0.97 per log increase). While there are limitations to the ecologic nature of these data, this analysis offers evidence of a protective relationship between antiviral drug supply and influenza mortality and supports a role for influenza antiviral use in future pandemics.

  7. Reduced levels of histones H1o and H1b, and unaltered content of methylated DNA in rainbow trout hepatocellular carcinoma chromatin.

    Science.gov (United States)

    Davie, J R; Delcuve, G P; Nickel, B E; Moirier, R; Bailey, G

    1987-10-15

    The levels of histone subtypes and DNA methylation of aflatoxin-induced rainbow trout hepatocellular carcinoma and adult liver nuclei were compared. The hepatocellular carcinoma nuclei were enriched in the ubiquitinated species of histone H2A and depleted in histones H1o and H1b. The 5-methylcytosine content and methylation patterns of the vitellogenin genes and the transcriptionally inactive TPG-3 protamine gene were not altered in the trout hepatocellular carcinoma DNA. Thus, undermethylation of DNA is not a general feature of chemically induced tumors in vivo.

  8. Implicações da influenza A/H1N1 no período gestacional = Implications of H1N1 influenza during pregnancy

    Directory of Open Access Journals (Sweden)

    Pastore, Ana Paula Winter

    2012-01-01

    Conclusões: Os estudos apontam que os possíveis fatores de morbidade e mortalidade entre gestantes acometidas pelo vírus influenza A/H1N1 foram síndrome de desconforto respiratório do adulto, embolia pulmonar, edema pulmonar, pneumonia bacteriana secundária e insuficiência renal. Além disso, as complicações durante a gravidez tendem a acontecer mais no segundo e terceiro trimestre. Medidas preventivas e um adequado tratamento provavelmente diminuirão o número de casos futuros de influenza pandêmica A/H1N1

  9. Drift Chambers detectors; Detectores de deriva

    Energy Technology Data Exchange (ETDEWEB)

    Duran, I.; Martinez laso, L.

    1989-07-01

    We present here a review of High Energy Physics detectors based on drift chambers. The ionization, drift diffusion, multiplication and detection principles are described. Most common drift media are analysed, and a classification of the detectors according to its geometry is done. Finally the standard read-out methods are displayed and the limits of the spatial resolution are discussed. (Author) 115 refs.

  10. Pandemic H1N1 2009 virus in Danish pigs: Diagnosis and lack of surveillance

    DEFF Research Database (Denmark)

    Larsen, Lars Erik; Nielsen, L. P.; Breum, Solvej Østergaard

    in swine with a genetic profile similar to older circulating strains implied a challenge for the veterinary diagnostic laboratories. We report the development, validation and implementation of a diagnostic strategy for specific diagnosis of H1N1v in pigs and the results of tests of pigs performed...... likely would recognize the H1N1v virus and this was further confirmed in the laboratory by test of samples from pvH1N1 infected humans. However, these assays could not discriminate between the typical circulating strains and the H1N1v subtype. For specific detection of the H1N1v subtype, an rRT-PCR assay...... targeting the HA gene developed at the Staten Serum Institute for diagnosis of H1N1v in humans was validated for use on pig specimens. In silico analysis showed that the probe and primers had 100% identity to published H1N1v strains and 80- 95% identity to classical-swine H1N1 which do not circulate...

  11. Life threatening severe Influenza A Virus (H1N1) infection in ...

    African Journals Online (AJOL)

    We report a case of H1N1 influenza in a 23-year old female with 28 weeks of gestation, who developed acute respiratory distress syndrome, required mechanical ventilation and eventually recovered. KEYWORDS: H1N1; Acute Respiratory Distress Syndrome; Pregnancy; Influenza Internet Journal of Medical Update 2012 ...

  12. A retrospective evaluation of critically ill patients infected with H1N1 ...

    African Journals Online (AJOL)

    Background: H1N1 influenza A virus infections were first reported in April 2009 and spread rapidly, resulting in mortality worldwide. The aim of this study was to evaluate patients with H1N1 infection treated in the intensive care unit (ICU) in Bursa, Turkey. Methods: Demographic characteristics, clinical features, and outcome ...

  13. Reassortant Pandemic (H1N1) 2009 Virus in Pigs, United Kingdom

    Science.gov (United States)

    Howard, Wendy A.; Essen, Steve C.; Strugnell, Benjamin W.; Russell, Christine; Barrass, Laura; Reid, Scott M.

    2011-01-01

    Surveillance for influenza virus in pigs in the United Kingdom during spring 2010 detected a novel reassortant influenza virus. This virus had genes encoding internal proteins from pandemic (H1N1) 2009 virus and hemagglutinin and neuraminidase genes from swine influenza virus (H1N2). Our results demonstrate processes contributing to influenza virus heterogeneity. PMID:21749767

  14. Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus.

    Science.gov (United States)

    Liu, Mi; Zhao, Xiang; Hua, Sha; Du, Xiangjun; Peng, Yousong; Li, Xiyan; Lan, Yu; Wang, Dayan; Wu, Aiping; Shu, Yuelong; Jiang, Taijiao

    2015-09-28

    The influenza A (H1N1) virus causes seasonal epidemics that result in severe illnesses and deaths almost every year. A deep understanding of the antigenic patterns and evolution of human influenza A (H1N1) virus is extremely important for its effective surveillance and prevention. Through development of antigenicity inference method for human influenza A (H1N1), named PREDAC-H1, we systematically mapped the antigenic patterns and evolution of the human influenza A (H1N1) virus. Eight dominant antigenic clusters have been inferred for seasonal H1N1 viruses since 1977, which demonstrated sequential replacements over time with a similar pattern in Asia, Europe and North America. Among them, six clusters emerged first in Asia. As for China, three of the eight antigenic clusters were detected in South China earlier than in North China, indicating the leading role of South China in H1N1 transmission. The comprehensive view of the antigenic evolution of human influenza A (H1N1) virus can help formulate better strategy for its prevention and control.

  15. Absence of somatic histone H1 in oocytes and preblastula embryos of Xenopus laevis

    NARCIS (Netherlands)

    Hock, R.; Moorman, A.; Fischer, D.; Scheer, U.

    1993-01-01

    Available data on the occurrence and expression of somatic histone H1 during oogenesis and early embryogenesis of Xenopus laevis are contradictory. In particular the reported presence of a large storage pool of histone H1A in oocytes is difficult to reconcile with the high transcriptional activity

  16. Influenza A (H1N1) neuraminidase inhibitors from Vitis amurensis

    DEFF Research Database (Denmark)

    Nguyen, Ngoc Anh; Dao, Trong Tuan; Tung, Bui Thanh

    2011-01-01

    Recently, a novel H1N1 influenza A virus (H1N1/09 virus) was identified and considered a strong candidate for a novel influenza pandemic. As part of an ongoing anti-influenza screening programme on natural products, eight oligostilbenes were isolated as active principles from the methanol extract...

  17. Safety of pandemic H1N1 vaccines in children and adolescents

    NARCIS (Netherlands)

    E.G. Wijnans (Leonoor); S. de Bie (Sandra); J.P. Dieleman (Jeanne); J. Bonhoeffer (Jan); M.C.J.M. Sturkenboom (Miriam)

    2011-01-01

    textabstractDuring the 2009 influenza A (H1N1) pandemic several pandemic H1N1 vaccines were licensed using fast track procedures, with relatively limited data on the safety in children and adolescents. Different extensive safety monitoring efforts were put in place to ensure timely detection of

  18. A retrospective evaluation of critically ill patients infected with H1N1 ...

    African Journals Online (AJOL)

    2009-11-12

    Nov 12, 2009 ... Abstract. Background: H1N1 influenza A virus infections were first reported in April 2009 and spread rapidly, resulting in mortality worldwide. The aim of this study was to evaluate patients with H1N1 infection treated in the intensive care unit (ICU) in. Bursa, Turkey. Methods: Demographic characteristics ...

  19. H1N1 Flu & U.S. Schools: Answers to Frequently Asked Questions

    Science.gov (United States)

    US Department of Education, 2009

    2009-01-01

    A severe form of influenza known as H1N1, commonly being called swine flu, has health officials around the world concerned. In the United States, the outbreak of H1N1 has prompted school closures and cancellation of school-related events. As the flu spreads, the Department of Education encourages school leaders, parents and students to know how to…

  20. 78 FR 69539 - Removal of Attestation Process for Facilities Using H-1A Registered Nurses

    Science.gov (United States)

    2013-11-20

    ... governing health care facilities using nonimmigrant foreign workers as registered nurses under the H-1A visa... legislation provided for extending the stay until September 30, 1997, of certain foreign workers who: (1... for foreign workers who were in, or had previously been given, nonimmigrant H-1A status as registered...

  1. Function and coding in the blowfly H1 neuron during naturalistic optic flow

    NARCIS (Netherlands)

    Hateren, J.H. van; Kern, R.; Schwerdtfeger, G.; Egelhaaf, M.

    2005-01-01

    Naturalistic stimuli, reconstructed from measured eye movements of flying blowflies, were replayed on a panoramic stimulus device. The directional movement-sensitive H1 neuron was recorded from blowflies watching these stimuli. The response of the H1 neuron is dominated by the response to fast

  2. Allergen Ara h 1 occurs in peanuts as a large oligomer rather than as a trimer

    NARCIS (Netherlands)

    Boxtel, E.L. van; Beers, M.M.C. van; Koppelman, S.J.; Broek, L.A.M. van den; Gruppen, H.

    2006-01-01

    Ara h 1, a major peanut allergen, is known as a stable trimeric protein. Nevertheless, upon purification of native Ara h 1 from peanuts using only size exclusion chromatography, the allergen appeared to exist in an oligomeric structure, rather than as a trimeric structure. The oligomeric structure

  3. Pandemic (H1N1) 2009 outbreak on pig farm, Argentina.

    Science.gov (United States)

    Pereda, Ariel; Cappuccio, Javier; Quiroga, Maria A; Baumeister, Elsa; Insarralde, Lucas; Ibar, Mariela; Sanguinetti, Ramon; Cannilla, Maria L; Franzese, Debora; Escobar Cabrera, Oscar E; Craig, Maria I; Rimondi, Agustina; Machuca, Mariana; Debenedetti, Rosa T; Zenobi, Carlos; Barral, Leonardo; Balzano, Rodrigo; Capalbo, Santiago; Risso, Adriana; Perfumo, Carlos J

    2010-02-01

    In June-July 2009, an outbreak of pandemic (H1N1) 2009 infection occurred on a pig farm in Argentina. Molecular analysis indicated that the virus was genetically related to the pandemic (H1N1) 2009 influenza virus strain. The outbreak presumably resulted from direct human-to-pig transmission.

  4. Bilan du programme autrichien de recherche sur les paysages

    Directory of Open Access Journals (Sweden)

    Karolina Begusch-Pfefferkorn

    2009-03-01

    Full Text Available Austrian Landscape Research, a programme of the Austrian Ministry of Science, has created scientific foundations for the sustainable development of Austrian landscapes and regions (plus bordering regions. Landscapes and regions were to be explored from different angles; implementing the research findings was to be part of the research work. The programme was designed to make room for science open to society, for unconventional ideas, methods, and courses of action. Programmatic targets and research principles supported this intent. The results of the programme met with national and international approval. The ALR knowledge balance is an attempt at presenting and assessing the achievements of this comprehensive contract research programme.Le programme du Ministère autrichien des Sciences, intitulé « Recherche sur le paysage autrichien », visait à construire les fondements scientifiques d’un développement durable des paysages et des régions de l’Autriche et des territoires limitrophes. Les paysages et les régions ont été étudiés selon différentes approches disciplinaires et la mise en pratique des résultats de cette étude était partie prenante du programme de recherche. La vocation de ce programme était de faire la place à une science ouverte sur la société, à des idées, méthodes et pratiques non conventionnelles. Les objectifs du programme et les principes de recherche vont dans le sens de ces exigences. Les résultats du programme ont été reconnus sur le plan national et international. Le bilan des connaissances du programme de recherche sur le paysage autrichien (KLF a pour but de présenter et d’évaluer les performances de ce vaste programme de recherche.

  5. Health costs from hospitalization with H1N1 infection during the 2009–2010 influenza pandemic compared with non-H1N1 respiratory infections

    Directory of Open Access Journals (Sweden)

    Courcoutsakis N

    2012-03-01

    Full Text Available Paul Zarogoulidis1, Dimitrios Glaros2,3, Theodoros Kontakiotis1, Marios Froudarakis4, loannis Kioumis1, loannis Kouroumichakis3, Anastasios Tsiotsios1, Anastasios Kallianos5, Paschalis Steiropoulos4, Konstantinos Porpodis1, Evagelia Nena6, Despoina Papakosta1, Aggeliki Rapti5, Theodoros C Constantinidis6, Theodora Kerenidi7, Maria Panopoulou8, Georgia Trakada9, Nikolaos Courcoutsakis10, Evangelia Fouka11, Konstantinos Zarogoulidis1, Efstratios Maltezos2,31Aristotle University of Thessaloniki, Pulmonary Department, "G Papanikolaou" Hospital, Exochi, Thessaloniki, 2Unit of Infectious Diseases, General University Hospital of Alexandroupolis, 3Second Department of Internal Medicine, 4Pulmonary Department, General University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, 52nd Pulmonology Clinic, Hospital of Chest Diseases "SOTIRIA," Athens, 6Laboratory of Hygiene and Environmental Protection, Occupational Medicine Section, Teaching Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, Greece, Alexandroupolis, 7Pulmonary Department, University of Larissa, Larissa, 8Microbiology Department, General University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, 9Pulmonary Department, University of Athens, Athens, 10Radiology Department, General University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, 111st Pulmonary Department, "G Papanikolaou" Hospital, Exochi, Thessaloniki, GreeceBackground: The first positive patient with influenza A (H1N1 was recorded in March 2009 and the pandemic continued with new outbreaks throughout 2010. This study's objective was to quantify the total cost of inpatient care and identify factors associated with the increased cost of the 2009–2010 influenza A pandemic in comparison with nonviral respiratory infection.Methods: In total, 133 positive and 103 negative H1N1 patients were included from three tertiary

  6. Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication.

    Science.gov (United States)

    Holmes, J Bradley; Akman, Gokhan; Wood, Stuart R; Sakhuja, Kiran; Cerritelli, Susana M; Moss, Chloe; Bowmaker, Mark R; Jacobs, Howard T; Crouch, Robert J; Holt, Ian J

    2015-07-28

    Encoding ribonuclease H1 (RNase H1) degrades RNA hybridized to DNA, and its function is essential for mitochondrial DNA maintenance in the developing mouse. Here we define the role of RNase H1 in mitochondrial DNA replication. Analysis of replicating mitochondrial DNA in embryonic fibroblasts lacking RNase H1 reveals retention of three primers in the major noncoding region (NCR) and one at the prominent lagging-strand initiation site termed Ori-L. Primer retention does not lead immediately to depletion, as the persistent RNA is fully incorporated in mitochondrial DNA. However, the retained primers present an obstacle to the mitochondrial DNA polymerase γ in subsequent rounds of replication and lead to the catastrophic generation of a double-strand break at the origin when the resulting gapped molecules are copied. Hence, the essential role of RNase H1 in mitochondrial DNA replication is the removal of primers at the origin of replication.

  7. Structural and dynamic properties of linker histone H1 binding to DNA

    CERN Document Server

    Dootz, Rolf; Pfohl, Thomas

    2010-01-01

    Found in all eukaryotic cells, linker histones H1 are known to bind to and rearrange nucleosomal linker DNA. In vitro, the fundamental nature of H1/DNA interactions has attracted wide interest among research communities - for biologists from a chromatin organization deciphering point of view, and for physicists from the study of polyelectrolyte interactions point of view. Hence, H1/DNA binding processes, structural and dynamical information about these self-assemblies is of broad importance. Targeting a quantitative understanding of H1 induced DNA compaction mechanisms our strategy is based on using small angle X-ray microdiffraction in combination with microfluidics. The usage of microfluidic hydrodynamic focusing devices facilitate a microscale control of these self-assembly processes. In addition, the method enables time-resolved access to structure formation in situ, in particular to transient intermediate states. The observed time dependent structure evolution shows that the interaction of H1 with DNA ca...

  8. Novel Influenza A (H1N1)-Associated Acute Necrotizing Encephalopathy: A Case Report

    Science.gov (United States)

    Kim, Ki Jung; Park, Eun Sook; Chang, Hyun Jung; Suh, Miri

    2013-01-01

    Several cases of acute necrotizing encephalopathy (ANE) with influenza A (H1N1) have been reported to date. The prognosis of ANE associated with H1N1 is variable; some cases resulted in severe neurologic complication, whereas other cases were fatal. Reports mostly focused on the diagnosis of ANE with H1N1 infection, rather than functional recovery. We report a case of ANE with H1N1 infection in a 4-year-old Korean girl who rapidly developed fever, seizure, and altered mentality, as well as had neurologic sequelae of ataxia, intentional tremor, strabismus, and dysarthria. Brain magnetic resonance imaging showed lesions in the bilateral thalami, pons, and left basal ganglia. To our knowledge, this is the first report of ANE caused by H1N1 infection and its long-term functional recovery in Korea. PMID:23705127

  9. Thermal kinetic inductance detector

    Science.gov (United States)

    Cecil, Thomas; Gades, Lisa; Miceli, Antonio; Quaranta, Orlando

    2016-12-20

    A microcalorimeter for radiation detection that uses superconducting kinetic inductance resonators as the thermometers. The detector is frequency-multiplexed which enables detector systems with a large number of pixels.

  10. The LDC detector concept

    Indian Academy of Sciences (India)

    ), the large detector concept (LDC) is being developed. The main points of the LDC are a large volume gaseous tracking system, combined with high precision vertex detector and an extremely granular calorimeter. The main design force ...

  11. Novel influenza A(H1N1) 2009 in vitro reassortant viruses with oseltamivir resistance.

    Science.gov (United States)

    Ottmann, Michèle; Duchamp, Maude Bouscambert; Casalegno, Jean-Sébastien; Frobert, Emilie; Moulès, Vincent; Ferraris, Olivier; Valette, Martine; Escuret, Vanessa; Lina, Bruno

    2010-01-01

    With the recent emergence of the novel A(H1N1) virus in 2009, the efficacy of available drugs, such as neuraminidase (NA) inhibitors, is of great concern for good patient care. Influenza viruses are known to be able to acquire resistance. In 2007, A(H1N1) viruses related to A/Brisbane/59/2007 (H1N1) (A[H1N1] Brisbane-like virus), which are naturally resistant to oseltamivir, emerged. Resistance to oseltamivir can be acquired either by spontaneous mutation in the NA (H275Y in N1), or by reassortment with a mutated NA. It is therefore crucial to determine the risk of pandemic A(H1N1) 2009 virus acquiring resistance against oseltamivir by reassortment. We estimated the capacity of reassortment between the A(H1N1) 2009 virus and an oseltamivir-resistant A(H1N1) Brisbane-like virus by in vitro coinfections of influenza-permissive cells. The screening and the analysis of reassortant viruses was performed by specific reverse transcriptase PCRs and by sequencing. Out of 50 analysed reassortant viruses, two harboured the haemagglutinin (HA) segment from the pandemic A(H1N1) 2009 virus and the mutated NA originated from the A(H1N1) Brisbane-like virus. The replicating capacities of these viruses were measured, showing no difference as compared to the two parental strains, suggesting that acquisition of the mutated NA segment did not impair viral fitness in vitro. Our results suggest that the novel A(H1N1) 2009 virus can acquire by in vitro genetic reassortment the H275Y mutated NA segment conferring resistance to oseltamivir.

  12. nm23-H1 expression in non-Hodgkin and Hodgkin lymphomas.

    Science.gov (United States)

    Bircan, Sema; Inamdar, Kedar V; Rassidakis, George Z; Medeiros, L J

    2008-05-01

    We assessed for nm23-H1 expression in 262 lymphoid neoplasms including 191 B-cell non-Hodgkin lymphoma (NHL), 54 T-cell NHL, and 17 Hodgkin lymphoma (HL). We used a monoclonal anti-nm23-H1 antibody, routinely processed tissue, and immunohistochemical methods. We semiquantified the percentage of positive cells (0%, 75%) and also estimated staining intensity (1 to 3+). Some percentage of nm23-H1 positive cells was detected in almost all types of NHL and HL, but T-cell NHL (87%) and HL (94.1%) more frequently had >75% positive cells than B-cell NHL (47.6%) (T- NHL vs. B-NHL, Ptypes of NHL and HL the nm23-H1 immunoreactivity was predominantly cytoplasmic. However, in plasma cell myeloma (PCM) nm23-H1 immunoreactivity was predominantly nuclear. In B-cell NHL, the percentage of nm23-H1-positive cells and the intensity of staining was not significantly different between various lymphoma types with the exception of PCM. We conclude that nm23-H1 is expressed in most types of B-cell and T-cell NHLs and HL, with a greater number of positive cells and higher staining intensity in T-cell NHL and HL, and PCM often being negative. The abundant intracellular expression of nm23-H1 suggests that serum levels of nm23-H1 are a reflection of tumor content. Unlike the conclusions of earlier studies, nm23-H1 expression in B-cell NHL was not significantly increased in clinically aggressive versus indolent neoplasms.

  13. Suv39h1 Protects from Myocardial Ischemia-Reperfusion Injury in Diabetic Rats

    Directory of Open Access Journals (Sweden)

    Bo Yang

    2014-04-01

    Full Text Available Background: Patients with diabetes are at increased risk of ischemic events. Suv39h1 is a histone methyltransferase that catalyzes the methylation of histone 3 lysine 9, which is associated with the suppression of inflammatory genes in diabetes. However, the role of Suv39h1 in myocardial ischemia/reperfusion (I/R injury under diabetic condition has not been evaluated. Methods: To generate diabetic model, male SD rats were fed with 60% fat diet followed by intraperitoneal injection with 40mg/kg streptozotocin. Adenovirus encoding Suv39h1 gene was used for Suv39h1 overexpression. Each rat received injections of adenovirus at five myocardial sites. Three days after gene transfection, each rat was subjected to left main coronary artery occlusion and reperfusion. After 30 min ischemia and reperfusion for 4 h, the rats were euthanized for real-time PCR, Western blot, immunohistochemical staining, and morphometric analysis. Results: Delivery of Ad-Suv39h1 into the hearts of diabetic rats could markedly increase Suv39h1 expression. Up-regulation of Suv39h1 significantly reduced infarct size and tissue damage after I/R injury, which was associated with protection from apoptosis of cardiac myocytes and reduction of inflammatory response. In addition, compared with injury group, Ad-Suv39h1 led to a decreased activity of mitogen-activated protein kinase family and its down-steam transcriptional factor NF-κB. Conclusion: Overexpression of Suv39h1 results in the de-activation of proinflammatory pathways and reduced apoptosis and myocardial injury. Therefore, Suv39h1 might represent a novel therapeutic strategy to reduce I/R injury under diabetic condition.

  14. Directeur associé (h/f) | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Cerner les questions de recherche clés dans les secteurs d'intervention du programme et formuler la stratégie de recherche en cours;; Élaborer, surveiller, gérer et évaluer des projets de recherche qui revêtent une importance cruciale pour les orientations stratégiques du programme;; Assurer la gestion globale et la ...

  15. Nouvelle initiative des chaires de recherche Canada-Afrique du Sud ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    8 déc. 2016 ... L'Initiative de partenariats trilatéraux des chaires de recherche Canada-Afrique du Sud a pour objectif d'investir dans le développement de la ... recherche du Canada ou chaire de recherche industrielle) et un chercheur principal provenant d'un autre pays d'Afrique visé par un accord bilatéral avec la NRF, ...

  16. Réseautage au sein des conseils subventionnaires de la recherche ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Réseautage au sein des conseils subventionnaires de la recherche en Afrique. Les conseils subventionnaires de la recherche scientifique sont essentiels au financement et à la promotion de la recherche et de l'innovation. Une récente étude de délimitation de la portée financée par le CRDI a souligné le rôle important ...

  17. La recherche sur le terrain ouvre des horizons au Vietnam | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Vivre les réalités de la recherche sur le terrain voilà ce que Claire Le Barbenchon, titulaire d'une bourse de recherche du CRDI en 2015, se remémore avec affection. « La recherche sur le terrain était une toute nouvelle expérience, mentionne-t-elle, et ce dans un pays encore inexploré pour moi : le Vietnam. »

  18. Demande de manifestations d'intérêt : Renforcer la recherche et la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Manfred Raffelsieper

    Cette demande de manifestation d'intérêt s'adresse particulièrement aux candidats dans deux volets distincts : 1) Les pôles de recherche industrielle : des partenariats pour un nouveau programme de recherche appliquée. Ce volet cible les universités axées sur la recherche et les entreprises des secteurs public ou privé.

  19. État de la recherche en sciences sociales en Inde (ITT Phase 2 ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Malgré la demande croissante enregistrée en Inde pour des recherches et des connaissances, le financement offert par le gouvernement pour la recherche en sciences sociales est limité, et se réduit comme une peau de chagrin depuis deux décennies. La majorité des établissements indépendants de recherche sur les ...

  20. Connaissances indigènes et recherche : Un guide à l'intention des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... de ces dernières. Connaissances indigènes et recherche contribuera à améliorer la conception, l'exécution, la surveillance et l'évaluation de tout programme de recherche et intéressera tant les professionnels du développement chevronnés que les novices ou les étudiants qui font leurs premières armes en recherche.

  1. Immunotherapeutic Potential of Oncolytic H-1 Parvovirus: Hints of Glioblastoma Microenvironment Conversion towards Immunogenicity

    Directory of Open Access Journals (Sweden)

    Assia L. Angelova

    2017-12-01

    Full Text Available Glioblastoma, one of the most aggressive primary brain tumors, is characterized by highly immunosuppressive microenvironment. This contributes to glioblastoma resistance to standard treatment modalities and allows tumor growth and recurrence. Several immune-targeted approaches have been recently developed and are currently under preclinical and clinical investigation. Oncolytic viruses, including the autonomous protoparvovirus H-1 (H-1PV, show great promise as novel immunotherapeutic tools. In a first phase I/IIa clinical trial (ParvOryx01, H-1PV was safe and well tolerated when locally or systemically administered to recurrent glioblastoma patients. The virus was able to cross the blood–brain (tumor barrier after intravenous infusion. Importantly, H-1PV treatment of glioblastoma patients was associated with immunogenic changes in the tumor microenvironment. Tumor infiltration with activated cytotoxic T cells, induction of cathepsin B and inducible nitric oxide (NO synthase (iNOS expression in tumor-associated microglia/macrophages (TAM, and accumulation of activated TAM in cluster of differentiation (CD 40 ligand (CD40L-positive glioblastoma regions was detected. These are the first-in-human observations of H-1PV capacity to switch the immunosuppressed tumor microenvironment towards immunogenicity. Based on this pilot study, we present a tentative model of H-1PV-mediated modulation of glioblastoma microenvironment and propose a combinatorial therapeutic approach taking advantage of H-1PV-induced microglia/macrophage activation for further (preclinical testing.

  2. Structure of the human histamine H1 receptor complex with doxepin.

    Science.gov (United States)

    Shimamura, Tatsuro; Shiroishi, Mitsunori; Weyand, Simone; Tsujimoto, Hirokazu; Winter, Graeme; Katritch, Vsevolod; Abagyan, Ruben; Cherezov, Vadim; Liu, Wei; Han, Gye Won; Kobayashi, Takuya; Stevens, Raymond C; Iwata, So

    2011-06-22

    The biogenic amine histamine is an important pharmacological mediator involved in pathophysiological processes such as allergies and inflammations. Histamine H(1) receptor (H(1)R) antagonists are very effective drugs alleviating the symptoms of allergic reactions. Here we show the crystal structure of the H(1)R complex with doxepin, a first-generation H(1)R antagonist. Doxepin sits deep in the ligand-binding pocket and directly interacts with Trp 428(6.48), a highly conserved key residue in G-protein-coupled-receptor activation. This well-conserved pocket with mostly hydrophobic nature contributes to the low selectivity of the first-generation compounds. The pocket is associated with an anion-binding region occupied by a phosphate ion. Docking of various second-generation H(1)R antagonists reveals that the unique carboxyl group present in this class of compounds interacts with Lys 191(5.39) and/or Lys 179(ECL2), both of which form part of the anion-binding region. This region is not conserved in other aminergic receptors, demonstrating how minor differences in receptors lead to pronounced selectivity differences with small molecules. Our study sheds light on the molecular basis of H(1)R antagonist specificity against H(1)R. ©2011 Macmillan Publishers Limited. All rights reserved

  3. Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin.

    Directory of Open Access Journals (Sweden)

    Ki Joon Cho

    Full Text Available Influenza viruses continuously undergo antigenic changes with gradual accumulation of mutations in hemagglutinin (HA that is a major determinant in subtype specificity. The identification of conserved epitopes within specific HA subtypes gives an important clue for developing new vaccines and diagnostics. We produced and characterized nine monoclonal antibodies that showed significant neutralizing activities against H1 subtype influenza viruses, and determined the complex structure of HA derived from a 2009 pandemic virus A/Korea/01/2009 (KR01 and the Fab fragment from H1-specific monoclonal antibody GC0587. The overall structure of the complex was essentially identical to the previously determined KR01 HA-Fab0757 complex structure. Both Fab0587 and Fab0757 recognize readily accessible head regions of HA, revealing broadly shared and conserved antigenic determinants among H1 subtypes. The β-strands constituted by Ser110-Glu115 and Lys169-Lys170 form H1 epitopes with distinct conformations from those of H1 and H3 HA sites. In particular, Glu112, Glu115, Lys169, and Lys171 that are highly conserved among H1 subtype HAs have close contacts with HCDR3 and LCDR3. The differences between Fab0587 and Fab0757 complexes reside mainly in HCDR3 and LCDR3, providing distinct antigenic determinants specific for 1918 pdm influenza strain. Our results demonstrate a potential key neutralizing epitope important for H1 subtype specificity in influenza virus.

  4. Histamine H1 Receptor Gene Expression and Drug Action of Antihistamines.

    Science.gov (United States)

    Fukui, Hiroyuki; Mizuguchi, Hiroyuki; Nemoto, Hisao; Kitamura, Yoshiaki; Kashiwada, Yoshiki; Takeda, Noriaki

    2017-01-01

    The upregulation mechanism of histamine H1 receptor through the activation of protein kinase C-δ (PKCδ) and the receptor gene expression was discovered. Levels of histamine H1 receptor mRNA and IL-4 mRNA in nasal mucosa were elevated by the provocation of nasal hypersensitivity model rats. Pretreatment with antihistamines suppressed the elevation of mRNA levels. Scores of nasal symptoms were correlatively alleviated to the suppression level of mRNAs above. A correlation between scores of nasal symptoms and levels of histamine H1 receptor mRNA in the nasal mucosa was observed in patients with pollinosis. Both scores of nasal symptoms and the level of histamine H1 receptor mRNA were improved by prophylactic treatment of antihistamines. Similar to the antihistamines, pretreatment with antiallergic natural medicines showed alleviation of nasal symptoms with correlative suppression of gene expression in nasal hypersensitivity model rats through the suppression of PKCδ. Similar effects of antihistamines and antiallergic natural medicines support that histamine H1 receptor-mediated activation of histamine H1 receptor gene expression is an important signaling pathway for the symptoms of allergic diseases. Antihistamines with inverse agonist activity showed the suppression of constitutive histamine H1 receptor gene expression, suggesting the advantage of therapeutic effect.

  5. Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia.

    Science.gov (United States)

    Banoei, Mohammad M; Vogel, Hans J; Weljie, Aalim M; Kumar, Anand; Yende, Sachin; Angus, Derek C; Winston, Brent W

    2017-04-19

    Metabolomics is a tool that has been used for the diagnosis and prognosis of specific diseases. The purpose of this study was to examine if metabolomics could be used as a potential diagnostic and prognostic tool for H1N1 pneumonia. Our hypothesis was that metabolomics can potentially be used early for the diagnosis and prognosis of H1N1 influenza pneumonia. (1)H nuclear magnetic resonance spectroscopy and gas chromatography-mass spectrometry were used to profile the metabolome in 42 patients with H1N1 pneumonia, 31 ventilated control subjects in the intensive care unit (ICU), and 30 culture-positive plasma samples from patients with bacterial community-acquired pneumonia drawn within the first 24 h of hospital admission for diagnosis and prognosis of disease. We found that plasma-based metabolomics from samples taken within 24 h of hospital admission can be used to discriminate H1N1 pneumonia from bacterial pneumonia and nonsurvivors from survivors of H1N1 pneumonia. Moreover, metabolomics is a highly sensitive and specific tool for the 90-day prognosis of mortality in H1N1 pneumonia. This study demonstrates that H1N1 pneumonia can create a quite different plasma metabolic profile from bacterial culture-positive pneumonia and ventilated control subjects in the ICU on the basis of plasma samples taken within 24 h of hospital/ICU admission, early in the course of disease.

  6. The Neurological Manifestations of H1N1 Influenza Infection; Diagnostic Challenges and Recommendations

    Directory of Open Access Journals (Sweden)

    Ali Akbar Asadi-Pooya

    2011-03-01

    Full Text Available Background: World Health Organization declared pandemic phase of human infection with novel influenza A (H1N1 in April 2009. There are very few reports about the neurological complications of H1N1 virus infection in the literature. Occasionally, these complications are severe and even fatal in some individuals. The aims of this study were to report neurological complaints and/or complications associated with H1N1 virus infection. Methods: The medical files of all patients with H1N1 influenza infection admitted to a specified hospital in the city of Shiraz, Iran from October through November 2009 were reviewed. More information about the patients were obtained by phone calls to the patients or their care givers. All patients had confirmed H1N1 virus infection with real-time PCR assay. Results: Fifty-five patients with H1N1 infection were studied. Twenty-three patients had neurological signs and/or symptoms. Mild neurological complaints may be reported in up to 42% of patients infected by H1N1 virus. Severe neurological complications occurred in 9% of the patients. The most common neurological manifestations were headache, numbness and paresthesia, drowsiness and coma. One patient had a Guillain-Barre syndrome-like illness, and died in a few days. Another patient had focal status epilepticus and encephalopathy. Conclusions: The H1N1 infection seems to have been quite mild with a self-limited course in much of the world, yet there appears to be a subset, which is severely affected. We recommend performing diagnostic tests for H1N1influenza virus in all patients with respiratory illness and neurological signs/symptoms. We also recommend initiating treatment with appropriate antiviral drugs as soon as possible in those with any significant neurological presentation accompanied with respiratory illness and flu-like symptoms

  7. Silicon detectors at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Brau, James E. [University of Oregon, Eugene, OR 97405-1274 (United States)], E-mail: jimbrau@uoregon.edu; Breidenbach, Martin [Stanford Linear Accelerator Center, Menlo Park, CA 94025 (United States); Baltay, Charles [Yale University, New Haven, CT 06520-8120 (United States); Frey, Raymond E.; Strom, David M. [University of Oregon, Eugene, OR 97405-1274 (United States)

    2007-09-01

    Silicon detectors are being developed for several applications in ILC detectors. These include vertex detection, tracking, electromagnetic calorimetry, and forward detectors. The advantages of silicon detector technology have been incorporated into a full detector design, SiD (the Silicon Detector). A brief overview of this effort is presented.

  8. Three-decade epidemiological analysis of Escherichia coli O15:K52:H1

    DEFF Research Database (Denmark)

    Olesen, Bente; Scheutz, Flemming; Menard, Megan

    2009-01-01

    The successful Escherichia coli O15:K52:H1 clonal group provides a case study for the emergence of multiresistant clonal groups of Enterobacteriaceae generally. Accordingly, we tested the hypotheses that, over time, the O15:K52:H1 clonal group has become increasingly (i) virulent and (ii) resistant...... to antibiotics. One hundred archived international E. coli O15:K52:[H1] clinical isolates from 100 unique patients (1975 to 2006) were characterized for diverse phenotypic and molecular traits. All 100 isolates derived from phylogenetic group D and, presumptively, sequence type ST393. They uniformly carried...

  9. Enseignement du français les apports de la recherche en linguistique

    CERN Document Server

    Avanzi, Mathieu; Corminboeuf, Gilles; Gachet, Frederic

    2014-01-01

    Cet ouvrage propose une reflexion collective sur la maniere dont l'enseignement du francais peut tirer profit (des resultats) de la recherche en linguistique. Le passage de la recherche a l'enseignement pose des questions fondamentales : comment traduire les travaux de recherche vers les contenus d'enseignement ? Comment choisir parmi les resultats de la recherche ceux qui ont vocation a etre adaptes utilement pour les besoins des apprenants ? Comment traiter le decalage souvent evoque entre le contenu des moyens d'enseignement et l'etat du savoir sur la langue ?

  10. High-energy detector

    Science.gov (United States)

    Bolotnikov, Aleksey E [South Setauket, NY; Camarda, Giuseppe [Farmingville, NY; Cui, Yonggang [Upton, NY; James, Ralph B [Ridge, NY

    2011-11-22

    The preferred embodiments are directed to a high-energy detector that is electrically shielded using an anode, a cathode, and a conducting shield to substantially reduce or eliminate electrically unshielded area. The anode and the cathode are disposed at opposite ends of the detector and the conducting shield substantially surrounds at least a portion of the longitudinal surface of the detector. The conducting shield extends longitudinally to the anode end of the detector and substantially surrounds at least a portion of the detector. Signals read from one or more of the anode, cathode, and conducting shield can be used to determine the number of electrons that are liberated as a result of high-energy particles impinge on the detector. A correction technique can be implemented to correct for liberated electron that become trapped to improve the energy resolution of the high-energy detectors disclosed herein.

  11. Pediatric Healthcare Response to Pandemic (H1N1) 2009 Influenza Stakeholder Meeting - Summary of Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    HCTT CHE

    2010-01-01

    The goal of the meeting was to bring together subject matter experts to develop tools and resources for use by the pediatric healthcare community in response to 2009 (H1N1) pandemic influenza activity during the 2009 influenza season.

  12. Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays

    Directory of Open Access Journals (Sweden)

    N. Bajwa

    2014-03-01

    Full Text Available Effective detection of Swine H1N1 Hemagglutinin peptide is crucial as it could be used as a positive control to screen for highly infectious flu strains such as Swine-Origin Influenza A (H1N1. Piezoresistive microcantilever arrays present a pathway towards highly sensitive and label-free detection of biomolecules by transducing the antigen-antibody binding into change in resistivity via induced surface stress variation. We demonstrate a mechanical transduction of Swine H1N1 Hemagglutinin peptide binding and suggest the employed technique may offer a potential platform for detection of the H1N1 virus, which could be clinically used to diagnose and provide subsequent relief.

  13. H1N1 infection in emergency surgery: A cautionary tale.

    LENUS (Irish Health Repository)

    Galbraith, J G

    2010-01-01

    Pandemic 2009 influenza A H1N1 has spread rapidly since its first report in Mexico in March 2009. This is the first influenza pandemic in over 40 years and it atypically affects previously healthy young adults, with higher rates of morbidity and mortality. The medical literature has been inundated with reports of H1N1 infection, the majority found in critical care and internal medicine journals with a relative paucity in the surgical literature. Despite this, it remains an important entity that can impact greatly on acute surgical emergencies. We present a case of previously healthy 31-year-old male who underwent open appendectomy. His post-operative recovery was complicated by acute respiratory distress syndrome secondary to H1N1 infection. This case report highlights the impact that H1N1 virus can have on acute surgical emergencies and how it can complicate the post-operative course.

  14. Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Rui; Ekiert, Damian C.; Krause, Jens C.; Hai, Rong; Crowe, Jr., James E.; Wilson, Ian A. (Sinai); (Scripps); (Vanderbilt)

    2010-05-25

    The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure, particularly within the Sa antigenic site, is extremely similar to those of human H1N1 viruses circulating early in the 20th century. The cocrystal structure of the 1918 hemagglutinin with 2D1, an antibody from a survivor of the 1918 Spanish flu that neutralizes both 1918 and 2009 H1N1 viruses, reveals an epitope that is conserved in both pandemic viruses. Thus, antigenic similarity between the 2009 and 1918-like viruses provides an explanation for the age-related immunity to the current influenza pandemic.

  15. H1N1 and influenza viruses: why pregnant women might be hesitant to be vaccinated.

    Science.gov (United States)

    Mirdamadi, Kamelia; Einarson, Adrienne

    2011-09-01

    I have been encouraging pregnant women to receive both the H1N1 and influenza vaccines since I became aware of Health Canada's guidelines. However, some of the women in my practice have heard conflicting information, often from media sources, and they are hesitant to be vaccinated. What is the evidence behind these guidelines, and should I really be convincing these women to be vaccinated? Pregnant women and growing fetuses are considered a population vulnerable to H1N1 and influenza viruses. Health Canada published a report in late 2010 estimating that this population was at increased risk of hospitalization and severe outcomes of H1N1 infection. Recommendations included pregnant women as a priority group to receive the H1N1 vaccine as well as the influenza vaccine. This information should be explained unambiguously to pregnant women, and they should be made aware of the sensationalism of media reports, which are often based on opinion and not evidence.

  16. The seroprevalence of pandemic influenza H1N1 (2009 virus in China.

    Directory of Open Access Journals (Sweden)

    Cuiling Xu

    2011-04-01

    Full Text Available Mainland China experienced pandemic influenza H1N1 (2009 virus (pH1N1 with peak activity during November-December 2009. To understand the geographic extent, risk factors, and attack rate of pH1N1 infection in China we conducted a nationwide serological survey to determine the prevalence of antibodies to pH1N1.Stored serum samples (n = 2,379 collected during 2006-2008 were used to estimate baseline serum reactogenicity to pH1N1. In January 2010, we used a multistage-stratified random sampling method to select 50,111 subjects who met eligibility criteria and collected serum samples and administered a standardized questionnaire. Antibody response to pH1N1 was measured using haemagglutination inhibition (HI assay and the weighted seroprevalence was calculated using the Taylor series linearization method. Multivariable logistic regression analyses were used to examine risk factors for pH1N1 seropositivity. Baseline seroprevalence of pH1N1 antibody (HI titer ≥40 was 1.2%. The weighted seroprevalence of pH1N1 among the Chinese population was 21.5%(vaccinated: 62.0%; unvaccinated: 17.1%. Among unvaccinated participants, those aged 6-15 years (32.9% and 16-24 years (30.3% had higher seroprevalence compared with participants aged 25-59 years (10.7% and ≥60 years (9.9%, P<0.0001. Children in kindergarten and students had higher odds of seropositivity than children in family care (OR: 1.36 and 2.05, respectively. We estimated that 207.7 million individuals (15.9% experienced pH1N1 infection in China.The Chinese population had low pre-existing immunity to pH1N1 and experienced a relatively high attack rate in 2009 of this virus. We recommend routine control measures such as vaccination to reduce transmission and spread of seasonal and pandemic influenza viruses.

  17. Seroepidemiology of pandemic influenza A (H1N1 2009 virus infections in Pune, India

    Directory of Open Access Journals (Sweden)

    Tandale Babasaheb V

    2010-08-01

    Full Text Available Abstract Background In India, Pune was one of the badly affected cities during the influenza A (H1N1 2009 pandemic. We undertook serosurveys among the risk groups and general population to determine the extent of pandemic influenza A (H1N1 2009 virus infections. Methods Pre-pandemic sera from the archives, collected during January 2005 to March 2009, were assayed for the determination of baseline seropositivity. Serosurveys were undertaken among the risk groups such as hospital staff, general practitioners, school children and staff and general population between 15th August and 11th December 2009. In addition, the PCR-confirmed pandemic influenza A (H1N1 2009 cases and their household contacts were also investigated. Haemagglutination-inhibition (HI assays were performed using turkey red blood cells employing standard protocols. A titre of ≥1:40 was considered seropositive. Results Only 2 (0.9% of the 222 pre-pandemic sera were positive. The test-retest reliability of HI assay in 101 sera was 98% for pandemic H1N1, 93.1% for seasonal H1N1 and 94% for seasonal H3N2. The sera from 48 (73.8% of 65 PCR-confirmed pandemic H1N1 cases in 2009 were positive. Seropositivity among general practitioners increased from 4.9% in August to 9.4% in November and 15.1% in December. Among hospital staff, seropositivity increased from 2.8% in August to 12% in November. Seropositivity among the schools increased from 2% in August to 10.7% in September. The seropositivity among students (25% was higher than the school staff in September. In a general population survey in October 2009, seropositivity was higher in children (9.1% than adults (4.3%. The 15-19 years age group showed the highest seropositivity of 20.3%. Seropositivity of seasonal H3N2 (55.3% and H1N1 (26.4% was higher than pandemic H1N1 (5.7% (n = 2328. In households of 74 PCR-confirmed pandemic H1N1 cases, 25.6% contacts were seropositive. Almost 90% pandemic H1N1 infections were asymptomatic or mild

  18. Nouvelles recherches a la Grotte Cosquer (Marseille

    Directory of Open Access Journals (Sweden)

    Luc Vanrell

    2005-01-01

    Full Text Available En juillet 1991, un plongeur sous-marin, HENRI COSQUER, découvrit des peintures et des gravures dans une grotte sous la mer près deMarseille, au Cap Morgiou. En 1991, 1992 et 1994, des séries de plongées furent organisées par le Ministère de la Culture, avec la participation de JEAN COURTIN, préhistorien et plongeur. D’autres recherches furent reprises dernièrement, en 2002 et 2003, par les cosignataires de l’article.La localisation extraordinaire de l’entrée de cette caverne est due à la montée du niveau de la mer après la fin de la dernière glaciation. Au maximum glaciaire, il y a 20.000 ans, la mer se trouvait 130 mètres plus bas qu’actuellement et la ligne de rivage était à 5 kilomètres de là.Les parois de toutes les galeries et salles submergées ont été corrodées et aucune peinture ni gravure n’y subsistent. L’art découvert se trouve dans des salles supérieures restées hors d’eau. Environ 177 figures d’animaux ont été répertoriées, ainsi que 216 signes géométriques de formes diverses, 65 mains négatives, et l’image d’un homme tué. Les sols sont jonchés de charbons, restes de torches ou de feux allumés pour obtenir le charbon nécessaire aux dessins. Les gens n’habitaient pas dans ces lieux retirés. Ils les utilisèrent pour leurs cérémonies mais également pour obtenir le mondmilch raclé sur les parois et des fragments de concrétions, qui servirent probablement comme « médecines ».Les 27 dates obtenues par la méthode du radiocarbone ont montré que la caverne avait été fréquentée pendant deux périodes principales, d’abord aux alentours de 26 à 27.000 ans avant le présent, puis il y a 19.000 ans environ.La grotte Cosquer, dont plus des trois-quarts de l’art furent sans doute détruits par son ennoiement, est une découverte majeure, par sa localisation en Provence, par les activités dont elle fut le théâtre, et par l’abondance du bestiaire, des mains et des

  19. Evolution and adaptation of the pandemic A/H1N1 2009 influenza virus

    Directory of Open Access Journals (Sweden)

    Ducatez MF

    2011-07-01

    Full Text Available Mariette F Ducatez, Thomas P Fabrizio, Richard J WebbyDepartment of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USAAbstract: The emergence of the 2009 H1N1 pandemic influenza virus [A(H1N1pdm09] has provided the public health community with many challenges, but also the scientific community with an opportunity to monitor closely its evolution through the processes of drift and shift. To date, and despite having circulated in humans for nearly two years, little antigenic variation has been observed in the A(H1N1pdm09 viruses. However, as the A(H1N1pdm09 virus continues to circulate and the immunologic pressure within the human population increases, future antigenic change is almost a certainty. Several coinfections of A(H1N1pdm09 and seasonal A(H1N1 or A(H3N2 viruses have been observed, but no reassortant viruses have been described in humans, suggesting a lack of fitness of reassortant viruses or a lack of opportunities for interaction of different viral lineages. In contrast, multiple reassortment events have been detected in swine populations between A(H1N1 pdm09 and other endemic swine viruses. Somewhat surprisingly, many of the well characterized influenza virus virulence markers appear to have limited impact on the phenotype of the A(H1N1pdm09 viruses when they have been introduced into mutant viruses in laboratory settings. As such, it is unclear what the evolutionary path of the pandemic virus will be, but the monitoring of any changes in the circulating viruses will remain a global public and animal health priority.Keywords: influenza, pandemic, evolution, adaptation

  20. Bleeding Follicular Conjunctivitis due to Influenza H1N1 Virus

    Directory of Open Access Journals (Sweden)

    Maria Jesus Lopez-Prats

    2010-01-01

    Full Text Available Influenza H1N1 or A virus is a new virus serotype capable of human-to-human transmission. This infection causes a flu syndrome similar to that of seasonal influenza, with only one case of conjunctivitis described and no clinical details or microbiological confirmation. Its diagnosis is performed by PCR of pharyngeal smear of the patients affected. We report the first well-documented case in the medical literature of conjunctivitis by H1N1 virus.

  1. Radiologic Findings of Influenza A (H1N1) Pneumonia: Report of Two Cases

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Jin Kyoung; Ahn, Myeong Im; Jung, Jung Im; Han, Dae Hee; Park, Seog Hee; Park, Chan Kwon; Kim, Young Kyoon [Seoul St. Mary' s Hospital, Seoul (Korea, Republic of)

    2010-08-15

    Novel influenza A (H1N1) infection is a highly infectious disease, which has been rapidly spreading worldwide since it was first documented in March of 2009 in Mexico. We experienced and report two cases of Influenza A (H1N1) pneumonia, accompanied by chest radiographic and CT findings. The chest radiographs revealed diffuse haziness and extensive airspace consolidation, whereas the CT scans demonstrated multifocal areas of ground glass opacity and airspace consolidation with a CT halo sign.

  2. Pandemic (H1N1) 2009 and Hajj Pilgrims Who Received Predeparture Vaccination, Egypt

    Science.gov (United States)

    Kandeel, Amr; Abdel Kereem, Eman; El-Refay, Samir; Afifi, Salma; Abukela, Mohammed; Earhart, Kenneth; El-Sayed, Nasr; El-Gabaly, Hatem

    2011-01-01

    In Egypt, vaccination against pandemic (H1N1) 2009 virus was required of pilgrims departing for the 2009 Hajj. A survey of 551 pilgrims as they returned to Egypt found 542 (98.1% [weighted]) reported receiving the vaccine; 6 (1.0% [weighted]) were infected with influenza virus A (H3N2) but none with pandemic (H1N1) 2009 virus. PMID:21762583

  3. Nodal-Dependent Mesendoderm Specification Requires the Combinatorial Activities of FoxH1 and Eomesodermin

    Science.gov (United States)

    Slagle, Christopher E.; Aoki, Tsutomu; Burdine, Rebecca D.

    2011-01-01

    Vertebrate mesendoderm specification requires the Nodal signaling pathway and its transcriptional effector FoxH1. However, loss of FoxH1 in several species does not reliably cause the full range of loss-of-Nodal phenotypes, indicating that Nodal signals through additional transcription factors during early development. We investigated the FoxH1-dependent and -independent roles of Nodal signaling during mesendoderm patterning using a novel recessive zebrafish FoxH1 mutation called midway, which produces a C-terminally truncated FoxH1 protein lacking the Smad-interaction domain but retaining DNA–binding capability. Using a combination of gel shift assays, Nodal overexpression experiments, and genetic epistasis analyses, we demonstrate that midway more accurately represents a complete loss of FoxH1-dependent Nodal signaling than the existing zebrafish FoxH1 mutant schmalspur. Maternal-zygotic midway mutants lack notochords, in agreement with FoxH1 loss in other organisms, but retain near wild-type expression of markers of endoderm and various nonaxial mesoderm fates, including paraxial and intermediate mesoderm and blood precursors. We found that the activity of the T-box transcription factor Eomesodermin accounts for specification of these tissues in midway embryos. Inhibition of Eomesodermin in midway mutants severely reduces the specification of these tissues and effectively phenocopies the defects seen upon complete loss of Nodal signaling. Our results indicate that the specific combinations of transcription factors available for signal transduction play critical and separable roles in determining Nodal pathway output during mesendoderm patterning. Our findings also offer novel insights into the co-evolution of the Nodal signaling pathway, the notochord specification program, and the chordate branch of the deuterostome family of animals. PMID:21637786

  4. Synthesis, characterization, and pharmacological studies of ferrocene-1H-1,2,3-triazole hybrids

    Science.gov (United States)

    Haque, Ashanul; Hsieh, Ming-Fa; Hassan, Syed Imran; Haque Faizi, Md. Serajul; Saha, Anannya; Dege, Necmi; Rather, Jahangir Ahmad; Khan, Muhammad S.

    2017-10-01

    A series of ferrocene-1H-1,2,3-triazole hybrids namely 1-(4-nitrophenyl)-4-ferrocenyl-1H-1,2,3-triazole (1), 1-(4,4‧-dinitro-2-biphenyl)-4-ferrocenyl-1H-1,2,3-triazole (2), 1-(3-chloro-4-fluorophenyl)-4-ferrocenyl-1H-1,2,3-triazole (3), 1-(4-bromophenyl)-4-ferrocenyl-1H-1,2,3-triazole (4) and 1-(2-nitrophenyl)-4-ferrocenyl-1H-1,2,3-triazole (5) were designed and synthesized by copper-catalyzed azide alkyne cycloaddition (CuAAC) reaction. All the new hybrids were characterized by microanalyses, NMR (1H and 13C), UV-vis, IR, ESI-MS and electrochemical techniques. Crystal structure of the compound (3) was solved by single crystal X-ray diffraction method. The structural (single crystal) and spectroscopic (UV-Vis. and IR) properties of the compound 3 have been analyzed and compared by complementary quantum modeling. Hybrids 1-5 exhibited low toxicity and demonstrated neuroprotective effect.

  5. Effects of simvastatin and 6-hydroxydopamine on histaminergic H1 receptor binding density in rat brains.

    Science.gov (United States)

    Hu, Chang-Hua; Deng, Chao; Mackovski, Nikolce; Long, Ling; Zhu, Cansheng; Yang, Yu; Wang, Yuge; Chen, Jiezhong; Huang, Xu-Feng; Wang, Qing

    2010-12-01

    Statins have been widely used for the treatment of a variety of medical conditions including psychoneurological disorders beyond their original use in lowering cholesterol. Histamine receptors play an important role in the regulation of neural activity, however, it is unknown whether statins act on histamine receptors, particularly for their neural regulatory effects. This study examined the effects of simvastatin and 6-hydroxydopamine (6-OHDA) lesions on histamine H1 receptors using [(3)H] pyrilamine binding autoradiography. Compared to the saline group, simvastatin (1 mg/kg/day) significantly decreased H1 receptor bindings in the primary motor cortex (M1), ventromedial hypothalamic nucleus (VMH), caudate putamen (CPu), accumbens core (AcbC) and prefrontal cortex (PfC) (all p<0.05); however 10 mg/kg/day simvastatin increased H1 receptor density only in the medial amygdaloid nucleus (Mep) (p<0.05), but had no significant effect in other regions examined. The 6-OHDA lesion did not alter H1 receptor binding density in most brain areas, except a trend decrease in the hippocampus (p=0.07) and a trend increase in the cingulate cortex (p=0.06). These results suggested that simvastatin has different effects on the H1 receptors in different rat brain regions depending on the doses. Therefore, simvastatin can modulate histaminergic neurotransmission in the brain, and support the role of H1 receptors in psychoneurological disorders. Copyright © 2010 Elsevier Inc. All rights reserved.

  6. H1N1 encephalitis with malignant edema and review of neurologic complications from influenza.

    Science.gov (United States)

    Akins, Paul Taylor; Belko, John; Uyeki, Timothy M; Axelrod, Yekaterina; Lee, Kenneth K; Silverthorn, James

    2010-12-01

    Influenza virus infection of the respiratory tract is associated with a range of neurologic complications. The emergence of 2009 pandemic influenza A (H1N1) virus has been linked to neurological complications, including encephalopathy and encephalitis. Case report and literature review. We reviewed case management of a 20-year old Hispanic male who developed febrile upper respiratory tract signs and symptoms followed by a confusional state. He had rapid neurologic decline and his clinical course was complicated by refractory seizures and malignant brain edema. He was managed with oseltamavir and peramavir, corticosteroids, intravenous gamma globulin treatment, anticonvulsants, intracranial pressure management with external ventricular drain placement, hyperosmolar therapy, sedation, and mechanical ventilation. Reverse transcriptase polymerase chain reaction analysis of nasal secretions confirmed 2009 H1N1 virus infection; cerebrospinal fluid (CSF) was negative for 2009 H1N1 viral RNA. Follow-up imaging demonstrated improvement in brain edema but restricted diffusion in the basal ganglia. We provide a review of the clinical spectrum of neurologic complications of seasonal influenza and 2009 H1N1, and current approaches towards managing these complications. 2009 H1N1-associated acute encephalitis and encephalopathy appear to be variable in severity, including a subset of patients with a malignant clinical course complicated by high morbidity and mortality. Since the H1N1 influenza virus has not been detected in the CSF or brain tissue in patients with this diagnosis, the emerging view is that the host immune response plays a key role in pathogenesis.

  7. Numerical Analysis of an H1-Galerkin Mixed Finite Element Method for Time Fractional Telegraph Equation

    Directory of Open Access Journals (Sweden)

    Jinfeng Wang

    2014-01-01

    Full Text Available We discuss and analyze an H1-Galerkin mixed finite element (H1-GMFE method to look for the numerical solution of time fractional telegraph equation. We introduce an auxiliary variable to reduce the original equation into lower-order coupled equations and then formulate an H1-GMFE scheme with two important variables. We discretize the Caputo time fractional derivatives using the finite difference methods and approximate the spatial direction by applying the H1-GMFE method. Based on the discussion on the theoretical error analysis in L2-norm for the scalar unknown and its gradient in one dimensional case, we obtain the optimal order of convergence in space-time direction. Further, we also derive the optimal error results for the scalar unknown in H1-norm. Moreover, we derive and analyze the stability of H1-GMFE scheme and give the results of a priori error estimates in two- or three-dimensional cases. In order to verify our theoretical analysis, we give some results of numerical calculation by using the Matlab procedure.

  8. Numerical analysis of an H1-Galerkin mixed finite element method for time fractional telegraph equation.

    Science.gov (United States)

    Wang, Jinfeng; Zhao, Meng; Zhang, Min; Liu, Yang; Li, Hong

    2014-01-01

    We discuss and analyze an H(1)-Galerkin mixed finite element (H(1)-GMFE) method to look for the numerical solution of time fractional telegraph equation. We introduce an auxiliary variable to reduce the original equation into lower-order coupled equations and then formulate an H(1)-GMFE scheme with two important variables. We discretize the Caputo time fractional derivatives using the finite difference methods and approximate the spatial direction by applying the H(1)-GMFE method. Based on the discussion on the theoretical error analysis in L(2)-norm for the scalar unknown and its gradient in one dimensional case, we obtain the optimal order of convergence in space-time direction. Further, we also derive the optimal error results for the scalar unknown in H(1)-norm. Moreover, we derive and analyze the stability of H(1)-GMFE scheme and give the results of a priori error estimates in two- or three-dimensional cases. In order to verify our theoretical analysis, we give some results of numerical calculation by using the Matlab procedure.

  9. Mechanisms of triggering H1 helix in prion proteins unfolding revealed by molecular dynamic simulation

    Science.gov (United States)

    Tseng, Chih-Yuan; Lee, H. C.

    2006-03-01

    In template-assistance model, normal Prion protein (PrP^C), the pathogen to cause several prion diseases such as Creutzfeldt-Jakob (CJD) in human, Bovine Spongiform Encephalopathy (BSE) in cow, and scrapie in sheep, converts to infectious prion (PrP^Sc) through a transient interaction with PrP^Sc. Furthermore, conventional studies showed S1-H1-S2 region in PrP^C to be the template of S1-S2 β-sheet in PrP^Sc, and Prion protein's conformational conversion may involve an unfolding of H1 and refolding into β-sheet. Here we prepare several mouse prion peptides that contain S1-H1-S2 region with specific different structures, which are corresponding to specific interactions, to investigate possible mechanisms to trigger H1 α-helix unfolding process via molecular dynamic simulation. Three properties, conformational transition, salt-bridge in H1, and hydrophobic solvent accessible surface (SAS) are analyzed. From these studies, we found the interaction that triggers H1 unfolding to be the one that causes dihedral angle at residue Asn^143 changes. Whereas interactions that cause S1 segment's conformational changes play a minor in this process. These studies offers an additional evidence for template-assistance model.

  10. [Epidemiology of Pandemic Influenza (H1N1) 2009 in Aichi Medical University Hospital].

    Science.gov (United States)

    Tani, Hiroya; Yamagishi, Yuka; Fuzimaki, Eriko; Kishi, Takahiko; Goto, Minehiro; Mikamo, Hiroshige

    2010-01-01

    We have analyzed epidemiology of pandemic influenza (H1N1) 2009 in Aichi Medical University hospital. As a result, the characteristics of pandemic influenza (H1N1) 2009 was as follows. (1) The number of ordered rapid diagnostic test was 2.8 times compared with the seasonal influenza period. The number of ordered rapid diagnostic test of the seasonal influenza period had the peak in January to March. However, the peak in pandemic influenza (H1N1) 2009 was November. Also, the number of samples on the weekend had been more than that of the weekday. (2) Positive rate of each diagnostic kit did not have the difference between the seasonal influenza (31.3 ± 1.8%) and pandemic influenza (H1N1) 2009 (29.6%). (3) Age on most ordered samples were less than ten years old, and the number of samples in 11 to 20 years old was twice in comparison with the seasonal influenza. (4) Pandemic influenza (H1N1) 2009 in influenza A accounted for 96.9%. (5) Sensitivity and specificity of ESPLINE Influenza A&B-N (FUJIREBIO, Inc., Tokyo, Japan) to the pandemic influenza (H1N1) 2009 were 100% and 100%, respectively. Also, sensitivity and specificity of prorasuto Flu (Mitsubishi Chemical Medience Corporation, Tokyo, Japan) were 77.3%and 98.5%, respectively.

  11. Respiratory failure presenting in H1N1 influenza with Legionnaires disease: two case reports.

    Science.gov (United States)

    Iannuzzi, Michele; De Robertis, Edoardo; Piazza, Ornella; Rispoli, Fabio; Servillo, Giuseppe; Tufano, Rosalba

    2011-10-21

    Media sensationalism on the H1N1 outbreak may have influenced decisional processes and clinical diagnosis. We report two cases of patients who presented in 2009 with coexisting H1N1 virus and Legionella infections: a 69-year-old Caucasian man and a 71-year-old Caucasian woman. In our cases all the signs and symptoms, including vomiting, progressive respiratory disease leading to respiratory failure, refractory hypoxemia, leukopenia, lymphopenia, thrombocytopenia, and elevated levels of creatine kinase and hepatic aminotransferases, were consistent with critical illness due to 2009 H1N1 virus infection. Other infectious disorders may mimic H1N1 viral infection especially Legionnaires' disease. Because the swine flu H1N1 pandemic occurred in Autumn in Italy, Legionnaires disease was to be highly suspected since the peak incidence usually occurs in early fall. We do think that our immediate suspicion of Legionella infection based on clinical history and X-ray abnormalities was fundamental for a successful resolution. Our two case reports suggest that patients with H1N1 should be screened for Legionella, which is not currently common practice. This is particularly important since the signs and symptoms of both infections are similar.

  12. Respiratory failure presenting in H1N1 influenza with Legionnaires disease: two case reports

    Directory of Open Access Journals (Sweden)

    Iannuzzi Michele

    2011-10-01

    Full Text Available Abstract Introduction Media sensationalism on the H1N1 outbreak may have influenced decisional processes and clinical diagnosis. Case Presentation We report two cases of patients who presented in 2009 with coexisting H1N1 virus and Legionella infections: a 69-year-old Caucasian man and a 71-year-old Caucasian woman. In our cases all the signs and symptoms, including vomiting, progressive respiratory disease leading to respiratory failure, refractory hypoxemia, leukopenia, lymphopenia, thrombocytopenia, and elevated levels of creatine kinase and hepatic aminotransferases, were consistent with critical illness due to 2009 H1N1 virus infection. Other infectious disorders may mimic H1N1 viral infection especially Legionnaires' disease. Because the swine flu H1N1 pandemic occurred in Autumn in Italy, Legionnaires disease was to be highly suspected since the peak incidence usually occurs in early fall. We do think that our immediate suspicion of Legionella infection based on clinical history and X-ray abnormalities was fundamental for a successful resolution. Conclusion Our two case reports suggest that patients with H1N1 should be screened for Legionella, which is not currently common practice. This is particularly important since the signs and symptoms of both infections are similar.

  13. Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines.

    Science.gov (United States)

    Stahl, Stephen M

    2008-12-01

    Numerous "antihistamines" as well as various psychotropic medications with antihistamine properties are widely utilized to treat insomnia. Over-the-counter sleep aids usually contain an antihistamine and various antidepressants and antipsychotics with antihistamine properties have sedative-hypnotic actions. Although widely used for the treatment of insomnia, many agents that block the histamine H1 receptor are also widely considered to have therapeutic limitations, including the development of next-day carryover sedation, as well as problems with chronic use, such as the development of tolerance to sedative-hypnotic actions and weight gain. Although these clinical actions are classically attributed to blockade of the H1 receptor, recent findings with H1 selective agents and H1 selective dosing of older agents are challenging these notions and suggest that some of the clinical limitations of current H1-blocking agents at their currently utilized doses could be attributable to other properties of these drugs, especially to their simultaneous actions on muscarinic, cholinergic, and adrenergic receptors. Selective H1 antagonism is emerging as a novel approach to the treatment of insomnia, without tolerance, weight gain, or the need for the restrictive prescription scheduling required of other hypnotics.

  14. Numerical Analysis of an H 1-Galerkin Mixed Finite Element Method for Time Fractional Telegraph Equation

    Science.gov (United States)

    Wang, Jinfeng; Zhao, Meng; Zhang, Min; Liu, Yang; Li, Hong

    2014-01-01

    We discuss and analyze an H 1-Galerkin mixed finite element (H 1-GMFE) method to look for the numerical solution of time fractional telegraph equation. We introduce an auxiliary variable to reduce the original equation into lower-order coupled equations and then formulate an H 1-GMFE scheme with two important variables. We discretize the Caputo time fractional derivatives using the finite difference methods and approximate the spatial direction by applying the H 1-GMFE method. Based on the discussion on the theoretical error analysis in L 2-norm for the scalar unknown and its gradient in one dimensional case, we obtain the optimal order of convergence in space-time direction. Further, we also derive the optimal error results for the scalar unknown in H 1-norm. Moreover, we derive and analyze the stability of H 1-GMFE scheme and give the results of a priori error estimates in two- or three-dimensional cases. In order to verify our theoretical analysis, we give some results of numerical calculation by using the Matlab procedure. PMID:25184148

  15. Inde | Page 88 | CRDI - Centre de recherches pour le ...

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    Le CRDI appuyait la recherche sur l'adaptation des humains à la variabilité et aux changements climatiques bien avant que l'expression « réchauffement de la planète » ne vienne dominer les manchettes à l'échelle mondiale. Read more about L'adaptation aux changements climatiques. Langue French. Il ne sera jamais ...

  16. Équipes de recherche sur la mise en oeuvre

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    gprudhomme

    17 mars 2014 ... des maladies, des blessures et des handicaps chez les mères, les nouveau-nés et les enfants en mettant en oeuvre des interventions efficaces et connues au moyen de stratégies efficientes et efficaces (de manière à toucher les personnes qui en ont le plus besoin). Un programme de recherche pour ...

  17. Initiative des conseils subventionnaires de la recherche scientifique ...

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    L'initiative comporte un investissement conjoint de 13,9 millions CAD sur cinq ans (2015-2020); on prévoit des contributions supplémentaires de la part des conseils ... Cette étude multinationale analyse les choix de carrière et le rendement de la recherche des jeunes chercheurs dans le secteur de l'éducation supérieure, ...

  18. Sophie D'Amours | CRDI - Centre de recherches pour le ...

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    Le 1er juin 2017, Mme Sophie D'Amours est devenue la première femme à occuper le poste de rectrice à l'Université Laval. Professeure au sein du département de génie mécanique depuis 1995, elle a également occupé le poste de vice-rectrice à la recherche et à la création de 2012 à 2015.

  19. Descriptif 2006-2011 | CRDI - Centre de recherches pour le ...

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    Le 28 juin 2006, le domaine de programme Innovation, politique et science (IPS) a présenté au Conseil des gouverneurs du CRDI un plan stratégique pour orienter la phase initiale (2006 2011) des recherches menées en vertu de sa toute première initiative de programme, qui a pour nom Innovation, technologie et société ...

  20. malawi : tous les projets | Page 2 | CRDI - Centre de recherches ...

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    L'initiative Gouvernance démocratique, droits des femmes et égalité entre les sexes du CRDI appuie un ensemble de recherches comparatives visant à déterminer si les institutions de démocratie et de gouvernance tiennent compte des droits des femmes et de l'égalité entre les sexes et, le cas échéant, de quelles façons.

  1. Plateforme de recherche sur la protection sociale, l'inclusion ...

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    Plateforme de recherche sur la protection sociale, l'inclusion financière et les TIC financée par plusieurs bailleurs de fonds. Le fait de ne pas avoir d'économies ou de ne presque pas en avoir peut être désastreux pour les familles pauvres. En situation de crise, ce manque de ressources peut forcer les ménages à réduire ...

  2. HIV/AIDS Monitor Country Studies | CRDI - Centre de recherches ...

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    RENEWAL, réseau régional sur le VIH/sida, les moyens de subsistance en milieu rural et la sécurité alimentaire - phase II. Créé en 2001, le Réseau régional de recherche sur le VIH/sida, les moyens de subsistance en milieu rural et la sécurité alimentaire (RENEWAL), regroupe des réseaux d'organismes nationaux du.

  3. Colombia : tous les projets | Page 7 | CRDI - Centre de recherches ...

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    Migration forcée des Colombiens : peur, mémoire historique et représentation publique - phase II. Projet. Ce projet fait suite à deux ans de recherches fructueuses menées dans le cadre du projet no 102661 sur la migration forcée des Colombiens à l'intérieur de leur pays ou vers l'Équateur ou le Canada. Date de début : 22 ...

  4. Publications | Page 146 | CRDI - Centre de recherches pour le ...

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    Nous communiquons les résultats des recherches que nous finançons et offrons du matériel de formation gratuit pour venir en aide aux chercheurs et aux institutions. ... Les polluants environnementaux de tous genres contaminent l'eau, l'air et la terre, mettant en péril la vie humaine et les écosystèmes. De plus, ils sont ...

  5. Publications | Page 9 | CRDI - Centre de recherches pour le ...

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    Nous communiquons les résultats des recherches que nous finançons et offrons du matériel de formation gratuit pour venir en aide aux chercheurs et aux institutions. ... et le pire du potentiel humain: elles sont des sites d'une violence et d'une insécurité énormes, mais exsudent la modernité et l'espoir d'une vie meilleure.

  6. lebanon : tous les projets | Page 2 | CRDI - Centre de recherches ...

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    Ce projet fournira un soutien institutionnel au nouveau Conseil arabe des sciences sociales (CASS) afin qu'il puisse réaliser un vaste programme de recherche. Date de ... Changements climatiques et infiltrations d'eau salée le long du littoral de la Méditerranée orientale: Vulnérabilité socioéconomique et adaptation. Projet.

  7. Publications | Page 10 | CRDI - Centre de recherches pour le ...

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    Ce rapport de l'Institut d'administration des affaires de Karachi est le point culminant de trois années de recherche sur les rôles sexospécifiques et la façon dont ils contribuent à la violence dans 12 quartiers populaires dans deux des plus grandes villes du Pakistan: Karachi et Rawalpindi-Islamabad. Il met en évidence le ...

  8. Bourse de recherche : Gouvernance et justice | CRDI - Centre de ...

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    6 sept. 2017 ... ... la région de l'Amérique Latine et des Caraïbes, et aux propositions comportant des objectifs précis et réalistes, ainsi qu'une méthodologie clairement définie. Qui plus est, la proposition doit démontrer la pertinence de la recherche proposée par rapport au programme Gouvernance et justice du CRDI.

  9. Bourse de recherche – Fondements pour l'innovation | CRDI ...

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    7 sept. 2016 ... La priorité sera accordée aux propositions comportant des objectifs précis et réalistes de même qu'une méthodologie clairement définie. Qui plus est, la proposition doit démontrer la pertinence de la recherche proposée par rapport aux débats locaux, nationaux et régionaux sur les politiques en Afrique.

  10. Bourse de recherche : Initiative Think tank | CRDI - Centre de ...

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    6 sept. 2017 ... La priorité sera accordée aux propositions comportant des objectifs précis et réalistes de même qu'une méthodologie clairement définie. Qui plus est, la proposition doit démontrer la pertinence de la recherche proposée par rapport aux débats locaux, nationaux et régionaux sur les politiques en Asie, ...

  11. Publications | Page 170 | CRDI - Centre de recherches pour le ...

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    Ce guide est destiné aux personnes qui travaillent dans le secteur de la recherche et du développement. Il présente les concepts de la communication participative pour le développement, traite des méthodes de communication bilatérale efficaces, et présente une méthodologie pour planifier,... Wastewater Use in Irrigated ...

  12. Bourse de recherche – Changements climatiques | CRDI - Centre ...

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    7 sept. 2016 ... La priorité sera accordée aux propositions comportant des objectifs précis et réalistes de même qu'une méthodologie clairement définie. Qui plus est, la proposition doit démontrer la pertinence de la recherche proposée par rapport aux débats locaux, nationaux et régionaux sur les politiques dans au ...

  13. Bourse de recherche – Initiative Think tank | CRDI - Centre de ...

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    7 sept. 2016 ... La priorité sera accordée aux propositions comportant des objectifs précis et réalistes de même qu'une méthodologie clairement définie. Qui plus est, la proposition doit démontrer la pertinence de la recherche proposée par rapport aux débats locaux, nationaux et régionaux sur les politiques en Asie, ...

  14. Lignes directrices pour la preparation des rapports de recherche

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    Jean-Claude Dumais

    varie considérablement d'un boursier à l'autre en fonction, entre autres, de la nature de la recherche, de la méthodologie utilisée et de la participation à des activités connexes comme des congrès ou des conférences. Tous les rapports doivent, cependant, comprendre les éléments suivants : 1. un calendrier des activités.

  15. Soutien institutionnel au Groupe de recherche en économie ...

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    Le Groupe de recherche en économie appliquée et théorique (GREAT) est un organisme indépendant et sans but lucratif établi depuis neuf ans à Bamako, au Mali. ... IDRC's support of BetterEvaluation, an international collaboration to improve evaluation practice and theory, has resulted in an online guide for an often ...

  16. L'Initiative des conseils subventionnaires de la recherche ...

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    18 déc. 2017 ... L'Initiative des conseils subventionnaires de la recherche scientifique en Afrique subsaharienne (IOSRS) a reçu un prix de la diplomatie scientifique de la part du gouvernement de l'Afrique du Sud lors de son forum sur les sciences de 2017, qui a eu lieu le 8 décembre à Pretoria. Les prix de la diplomatie ...

  17. Emploi et croissance | Page 20 | CRDI - Centre de recherches pour ...

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    Le projet de recherche Marchés du travail et croissance partagée en Amérique latine, financé par le CRDI et coordonné par le Centro de Estudios Distributivos ... Le fait de ne pas avoir d'économies ou de ne presque pas en avoir peut être désastreux pour les familles pauvres, plus particulièrement en période de crise.

  18. Coordonnateur de projet - Karianet | CRDI - Centre de recherches ...

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    Tâches ou responsabilités principales. Les responsabilités particulières du coordonnateur de projets sont regroupées en trois catégories : gestion des connaissances, gestion de la recherche et gestion de projets. En tant que gestionnaire de connaissances, le coordonnateur de projets assume un rôle directeur dans ces ...

  19. Des recherches qui favorisent la participation et l'autonomisation ...

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    prêtes à être mises en application, qui ont entraîné une hausse de la productivité et des revenus, ainsi que l'amélioration et la diversification de l'alimentation des femmes et des enfants. • Reconnaissant le rôle que les femmes chercheures peuvent jouer dans la recherche en agriculture, le Fonds a soutenu la formation ...

  20. Des effets durables : Asie | CRDI - Centre de recherches pour le ...

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    6 juin 2014 ... Les collectivités côtières vulnérables du Sri Lanka sont désormais mieux outillées pour survivre aux tsunamis, cyclones et autres catastrophes naturelles survenant soudainement. Ce degré accru de préparation est le fruit de travaux de recherche financés par le CRDI qui visaient à cerner les meilleurs ...

  1. Des mentors choisis avec soin | CRDI - Centre de recherches pour ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... les diverses versions de son texte. Il dit que leurs observations ont beaucoup amélioré la qualité de ses travaux. D'autres chercheurs ont apprécié les efforts déployés par leurs mentors pour leur faire connaître de nouvelles méthodes de recherche ou pour les encourager à aborder des questions familières sous un angle ...

  2. Professorat de recherche sur les droits de la personne reconnus ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le professeur Ron mènera des recherches sur les difficultés que pose le renforcement des droits de la personne dans les pays en développement. Il aura l'occasion de donner des exposés au personnel du Centre sur ses travaux et de contribuer directement à des programmes tels que le Fonds pour la bonne gouvernance ...

  3. Voir toutes les initiatives | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'African Institute for Mathematical Sciences (AIMS) offre à des diplômés africains une formation rigoureuse en mathématiques. AIMS a lancé en 2008 l'initiative À la recherche du prochain Einstein (AIMS-NEI) en vue de constituer, à l'échelle du continent, une masse critique de spécialistes de disciplines scientifiques et ...

  4. Publications | Page 16 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Bien que la recherche a largement montré que les adolescents ont besoin de réseaux sociaux positifs et de connexions interpersonnelles – capital social positif ... les jeunes âgés de 15 à 24 ans, une étape de la vie à laquelle ils devraient être en train de terminer leurs études secondaires et d'intégrer le marché du travail.

  5. Innovations en matière de recherche

    International Development Research Centre (IDRC) Digital Library (Canada)

    Produire des connaissances et les utiliser pour améliorer les conditions de vie des populations dans l'ensemble des pays en développement a toujours été au coeur des activités du CRDI. Cette démarche a parfois donné naissance à de nouveaux champs de recherche. Voici quelques-unes des nombreuses démarches ...

  6. Kenya | Page 59 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Langue English. Dans les champs d'Afrique subsaharienne, Alan Watson et le Groupe de recherche sur les plantes nuisibles de l'Université McGill luttent contre des parasites dévastateurs — naturellement. De toute évidence, quelque chose n'allait pas dans les deux champs de sorgho, culture céréalière courante en ...

  7. Publications | Page 142 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    C'est un document essentiel pour tout programme de recherche qui cherche à lutter contre la carence en vitamine A. Préparé en... Water Balances in the Eastern Mediterranean. Le manque d'eau potable est souvent une cause de déstabilisation, de migration et de conflits locaux dans le monde. C'est pourquoi on reconnaît ...

  8. Publications | Page 67 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Parlant de l'African Institute for Mathematical Sciences (AIMS) et de son plaisir de côtoyer des étudiants venus de partout sur le continent, une femme originaire de Madagascar rayonne : tout... Rapport technique final : la pratique de l'éthique et de la bioéthique et ses conséquences dans la recherche en Santé en Afrique ...

  9. Influence de la recherche sur les politiques (2009) | CRDI - Centre ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    4 mars 2003 ... Des connaissances aux politiques. Le CRDI et la conception des politiques publiques : évaluation stratégique de l'influence de la recherche sur les politiques publiques. Cette évaluation vise à préciser et à documenter ce que le CRDI entend par «influence sur les politiques», à examiner de plus près dans ...

  10. Des recherches qui favorisent la participation et l'autonomisation ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    5 mai 2016 ... La collection de fiches Recherche et changement, produite par WRENmedia, présente certaines des incidences que l'on commence à constater dans la foulée des projets subventionnés par le ... La culture du pois chiche profite à un plus grand nombred'agriculteurs et d'agricultrices du sud de l'Éthiopie.

  11. Kenya | Page 61 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Des recherches appuyées par le CRDI contribuent à exploiter le potentiel des réseaux de terminaux à très petite ouverture d'antenne (TTPO ou VSAT), la nouvelle génération de technologies satellitaires. Le défi : amorcer la révolution numérique. Read more about Connecter l'Afrique, du Cap au Caire. Langue French.

  12. Soutien institutionnel à des organismes de recherche sur les ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Cet objectif sera atteint au moyen de l'adoption de mesures ayant pour but de mieux outiller le personnel afin qu'il puisse réaliser des recherches rigoureuses, d'améliorer ... Le projet appuiera également la mise en place d'une plateforme qui permettra aux bénéficiaires de réseauter entre eux ainsi qu'avec un vaste cercle ...

  13. Foundations for Innovation | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Recherche sur les systèmes d'innovation et l'inclusion sociale dans les économies émergentes (les pays BRICS) et ailleurs. Comment la science, la technologie et l'innovation peuvent-elles contribuer à la réduction de la pauvreté et au développement inclusif, en particulier au Brésil, en Russie, en Inde, en Chine.

  14. Livres | Page 4 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Il s'agit du quatrième ouvrage d'une collection qui en comptera cinq et qui colligera les résultats de recherches intensives sur les systèmes d'innovation nationaux dans les pays BRICS : le Brésil,. Directeur(s) : José Cassiolato, Graziela Zucoloto, Dinesh Abrol et Liu Xielin. Maison(s) d'édition : Taylor and Francis, CRDI.

  15. Financing Innovation | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    27 sept. 2013 ... Il s'agit du cinquième ouvrage d'une collection qui en compte cinq et qui collige les résultats de recherches intensives sur les systèmes d'innovation nationaux dans les pays BRICS : le Brésil, la Russie, l'Inde, la Chine et l'Afrique du Sud. Il analyse le financement de la science, de la technologie et de ...

  16. Guides et formulaires | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Lignes directrices à l'intention des institutions. Demande de subvention de recherche du CRDI · Budget de proposition · Lignes directrices du CRDI pour la préparation du rapport d'étape technique · Lignes directrices du CRDI pour la préparation du rapport technique final · Lignes directrices du CRDI pour les dépenses de ...

  17. Asie centrale | Page 96 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'utilisation d'enzymes comme additifs alimentaires pour animaux a pris une expansion rapide au cours de la dernière décennie. Même si les avantages économiques et sociaux des enzymes sont bien établis, il faut pousser les travaux de recherche et de développement si l'on veut que les enzymes réalisent leur plein ...

  18. Dominique Charron | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    À titre de directrice du domaine de programme Agriculture et environnement, Dominique Charron veille au bon déroulement d'activités de recherche ayant pour but d'accroître la productivité de l'agriculture et la sécurité alimentaire et hydrique tout en veillant à assurer la pérennité de l'environnement. Elle dirige également ...

  19. Fondation de recherche M.S. Swaminathan - renforcement des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La Fondation de recherche M.S. Swaminathan (MSSRF) est un organisme sans but lucratif fondé en 1988. Au départ, la MSSRF soutenait de jeunes scientifiques qui abordaient des problèmes comme la dégradation des zones côtières et la hausse du niveau de la mer sur la côte est indienne au moyen d'une démarche ...

  20. Voir toutes les initiatives | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'initiative Partenariats internationaux pour des sociétés durables (PISD) donne lieu à des collaborations dont émanent des recherches de grande qualité qui viennent éclairer les débats savants, publics et sur les politiques de manière à contribuer à un développement social et économique équitable, inclusif et durable.

  1. Partenaires et initiatives | Page 2 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'initiative Partenariats internationaux pour des sociétés durables (PISD) donne lieu à des collaborations dont émanent des recherches de grande qualité qui viennent éclairer les débats savants, publics et sur les politiques de manière à contribuer à un développement social et économique équitable.

  2. Recherches sur la flore pliocène de Java

    NARCIS (Netherlands)

    Crié, M.L.

    1888-01-01

    En publiant ces premières recherches sur les plantes pliocènes de Java, c’est un plaisir pour moi de remercier le savant directeur du musée géologique de Leyde, monsieur K. Martin, qui m’a fait l’honneur de m’en confier l’étude. Un tel sujet ne pouvait être traité prématurément, et j’ai dû

  3. Forum de recherche économique - Financement de base 2012 ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    22 janv. 2016 ... Il met en valeur la recherche économique sur le développement durable et inclusif au Moyen-Orient et en Afrique du Nord. Au cours des trois prochaines années, ses travaux s'articuleront autour de sept domaines thématiques : l'équité, les changements climatiques, les marchés du travail, la transformation ...

  4. Pakistan : tous les projets | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Résultats. Affichage 1 - 10 de 55. Les institutions de recherche sur les politiques et les ODD liés à la santé : Créer des conditions favorables en Asie du Sud. Projet. Ce projet s'inscrit dans un ensemble de quatre projets pilotes qui examinent la faisabilité de l'Initiative Réflexion santé, un programme prospectif qui appuierait ...

  5. Publications | Page 184 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Democracy, Citizenship and Youth : Towards Social and Political Participation in Brazil. Quelle est la place des jeunes dans le monde complexe et en constante mutation d'aujourd'hui ? Les jeunes sont à la fois un miroir de leur société et son reflet et pourtant, la recherche les a nettement délaissés comme sujet d'étude.

  6. Bourse de recherche – Gouvernance et justice | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    7 sept. 2016 ... Le programme Gouvernance et justice recrute un boursier qui mènera des recherches sur les questions de résilience des collectivités et des institutions dans le contexte de conflit et de fragilité propre à la région du Moyen-Orient et de l'Afrique du Nord. Cela comprend une orientation sur des thèmes tels ...

  7. Publications | Page 125 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Une crise profonde — dont les principales manifestations sont le paludisme, le VIH/sida, la tuberculose, la malnutrition et l'anémie — secoue le secteur de la santé de l'Afrique subsaharienne depuis de nombreuses années.... Recherches dans la région du Moyen-Orient et de l'Afrique du Nord — Fès, la cybercapitale du ...

  8. Utilisation du site Web | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Savoir. Innovation. Solutions. Carrières · Communiquez avec nous · Plan du site. Abonnez-vous à notre bulletin pour recevoir les nouvelles du CRDI chaque mois. Abonnez-vous · Droits d'auteur · Éthique de la recherche · Politique de libre accès · Politique de confidentialité · Transparence · Utilisation du site Web. Suivez- ...

  9. La Fondation William et Flora Hewlett | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Innovation. Solutions. Carrières · Communiquez avec nous · Plan du site. Abonnez-vous à notre bulletin électronique dès maintenant pour recevoir des nouvelles et des articles d'opinion du CRDI chaque mois. Abonnez-vous · Droits d'auteur · Éthique de la recherche · Politique de libre accès · Politique de confidentialité ...

  10. Monte Solberg | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Innovation. Solutions. Carrières · Communiquez avec nous · Plan du site. Abonnez-vous à notre bulletin électronique dès maintenant pour recevoir des nouvelles et des articles d'opinion du CRDI chaque mois. Abonnez-vous · Droits d'auteur · Éthique de la recherche · Politique de libre accès · Politique de confidentialité ...

  11. Véronique Duvieusart | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Savoir. Innovation. Solutions. Carrières · Communiquez avec nous · Plan du site. Abonnez-vous à notre bulletin pour recevoir les nouvelles du CRDI chaque mois. Abonnez-vous · Droits d'auteur · Éthique de la recherche · Politique de libre accès · Politique de confidentialité · Transparence · Utilisation du site Web. Suivez- ...

  12. Conseil de recherches en sciences humaines du Canada | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Innovation. Solutions. Carrières · Communiquez avec nous · Plan du site. Abonnez-vous à notre bulletin électronique dès maintenant pour recevoir des nouvelles et des articles d'opinion du CRDI chaque mois. Abonnez-vous · Droits d'auteur · Éthique de la recherche · Politique de libre accès · Politique de confidentialité ...

  13. Publications | Page 149 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Grâce à la modélisation par ordinateur faisant appel à des techniques de pointe et à la consultation des collectivités, l'organisme bolivien Agua Sustentable a trouvé des solutions politiques à des conflits qui auraient pu s'avérer... Document de recherche 2 – GDE, pauvreté et équité. Mais malgré l'engagement réel ...

  14. Publications | Page 93 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La recherche en santé mentale reconnaît plusieurs habiletés aux travailleurs sociaux. Cependant, lorsqu''il est question de médication, élément central du plan de traitement en santé mentale, on constate que l''on attribue surtout aux travailleurs sociaux le rôle de veiller à l''observance de ce... Collection un_focus Minisites ...

  15. nigeria : tous les projets | Page 4 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le Centre for the Study of the Economies of Africa (CSEA) est un jeune centre de recherche indépendant et sans but lucratif qui a été établi en octobre 2007 à ... la vulnérabilité des systèmes ruraux-urbains du Nigeria face aux changements climatiques en diffusant les résultats du projet pilote mené dans la ville d'Aba, dans ...

  16. Des statistiques essentielles | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Par le passé, ce que nous savions de la mortalité en Afrique était en grande partie basé sur des hypothèses », fait valoir Don de Savigny, directeur de la recherche du PIEST et membre du conseil d'administration d'INDEPTH. Population and Health in Developing Countries remet en question ces hypothèses en s'appuyant, ...

  17. Changements climatiques | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Depuis 2006, le CRDI a financé plus de 100 projets liés au climat et à l'eau, en versant plus de 100 millions CAD à 70 institutions oeuvrant dans plus de 50 pays en Asie, en Afrique, en Amérique latine et dans les Caraïbes. Financement. Le programme Changements climatiques finance la recherche au moyen d'appels ...

  18. Soutien institutionnel au Consortium pour la recherche économique ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le Consortium pour la recherche économique et sociale (CRES) est une équipe de chercheurs pluridisciplinaire établie à Dakar, au Sénégal. Il compte cinq départements : Croissance et équité; Développement local, intégration régionale et mondialisation; Économie des ressources humaines; Secteur rural; Économie de ...

  19. Foire aux questions pour la bourse de recherche

    International Development Research Centre (IDRC) Digital Library (Canada)

    Jean-Claude Dumais

    Quand les résultats du concours seront-ils connus ? 7. Je dois effectuer un stage dans un organisme choisi par mon université. Le CRDI peut-il octroyer des fonds à cette fin ? 8. Pour quels programmes puis-je présenter une demande ? 9. Comment procédez-vous pour choisir les titulaires de la bourse de recherche ? 10.

  20. Pakistan : tous les projets | Page 5 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le Réseau sud-asiatique pour le développement et l'économie environnementale (SANDEE) aspire à renforcer les capacités de recherche dans les sphères de la pauvreté, du développement économique et des changements environnementaux au Bangladesh, au Bhoutan, en Inde, au Népal, au Pakistan, aux Maldives et ...

  1. Changements climatiques | Page 15 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    S'il se peut bien que les changements climatiques viennent aggraver le problème, il ressort de recherches menées dans deux bassins versants du sud du pays que la pollution industrielle, l'exploitation non réglementée des ressources et les changements d'utilisation des terres sont les principales menaces pour la qualité ...

  2. Inde | Page 74 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    S'il se peut bien que les changements climatiques viennent aggraver le problème, il ressort de recherches menées dans deux bassins versants du sud du pays que la pollution industrielle, l'exploitation non réglementée des ressources et les changements d'utilisation des terres sont les principales menaces pour la qualité ...

  3. Livres | Page 34 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Author(s): Oroub El-Abed. Publisher(s): Institute for Palestinian Studies, CRDI. ISBN: 9780887283130. Chercheurs et décideurs d'Afrique : Quelles synergies pour le développement ? Éclairer et influencer le processus de prise de décision politique par la recherche est une préoccupation de plus en plus importante pour les ...

  4. [Study on evolutionary origin of influenza A virus (H1N1) based on HA gene].

    Science.gov (United States)

    Lu, Yi-Han; Ju, Li-Wen; Jiang, Lu-Fang; Yang, Ji-Xing; Shi, Qiang; Jiang, Qing-Wu

    2009-07-01

    To determine the evolutionary rate and divergence time of influenza A virus HA gene isolated recently worldwide pandemic and explore the origin and its transmission. A total of 344 H1 sequences available in the GenBank (including 248 isolated from human, 84 from swine, 11 from avian, and 1 from ferret) and 7 isolated in Shanghai were collected. The nucleotide substitution rate and time to most recent common ancestor (tMRCA) was calculated using molecular clock theory and Bayesian Skyline Plot (BSP) based on Markov chain Monte Carlo. Then genetic phylogeny was constructed referring to posterior distribution. It was found that H1 sequences in the US from human, swine and avian were clustered significantly with swine H1 ones from Asia phylogenetically (Cluster US). The second cluster (Cluster Eurasian Human) nearly consisted of human H1 sequences isolated in other regions. The third cluster (Cluster Eurasian Animal) consisted of swine and avian H1 sequences from China and Italy respectively. As for all the H1 sequences, the evolutionary rate was of 2.57 x 10(-3) substitutions/site per year averagely (95% Highest Posterior Density: 1.96 x 10(-3) - 3.03 x 10(-3)/site per year). The estimated dates for tMRCA of human H1 in Europe and swine H1 in the mainland of China were the earliest, with the corresponding rates of 6.46 x 10(-3)/site per year and 0.97 x 10(-3)/site per year respectively. The tMRCAs of human and swine H1 sequences from the US were similar, with the rates of 5.86 x 10(-3)/site per year and 5.02 x 10(-3)/site per year. The present flu outbreak was possibly induced by long-term circulation of influenza A virus (H1N1) in human population and swine herds in America. There was no evidence proving that influenza virus in China involved in the present outbreak.

  5. Intense Seasonal A/H1N1 Influenza in Mexico, Winter 2013–2014

    Science.gov (United States)

    Dávila-Torres, Javier; Chowell, Gerardo; Borja-Aburto, Víctor H.; Viboud, Cécile; Grajalez-Muñiz, Concepción; Miller, Mark. A.

    2014-01-01

    Background and Aims A recrudescent wave of pandemic influenza A/H1N1 affected Mexico during the winter of 2013–2014 following a mild 2012–2013 A/H3N2 influenza season. Methods We compared the demographic and geographic characteristics of hospitalizations and inpatient deaths for severe acute respiratory infection (SARI) and laboratory-confirmed influenza during the 2013–2014 influenza season compared to previous influenza seasons, based on a large prospective surveillance system maintained by the Mexican Social Security health care system. Results A total of 14,236 SARI hospitalizations and 1,163 inpatient deaths (8.2%) were reported between October 1, 2013 and March 31, 2014. Rates of laboratory-confirmed A/H1N1 hospitalizations and deaths were significantly higher among individuals aged 30–59 years and lower among younger age groups for the 2013–2014 A/H1N1 season compared to the previous A/H1N1 season in 2011–2012 (χ2 test, p <0.001). The reproduction number for the winter 2013–2014 influenza season in central Mexico was estimated at 1.3–1.4, in line with that reported for the 2011–2012 A/H1N1 season but lower than during the initial waves of pandemic A/H1N1 activity in 2009. Conclusions We documented a substantial increase in the number of A/H1N1-related hospitalizations and deaths during the period from October 2013–March 2014 in Mexico and a proportionate shift of severe disease to middle-aged adults, relative to the preceding A/H1N1 2011–2012 season. In the absence of clear antigenic drift in globally circulating A/H1N1 viruses in the post-2009 pandemic period, the gradual change in the age distribution of A/H1N1 infections observed in Mexico suggests a slow build-up of immunity among younger populations, reminiscent of the age profile of past pandemics. PMID:25446616

  6. Second-generation H1-antihistamines in chronic urticaria: an evidence-based review.

    Science.gov (United States)

    Kavosh, Eric R; Khan, David A

    2011-12-01

    The effects of urticaria are predominantly mediated by histamine release; therefore, H1-antihistamines are the mainstay of treatment. Second-generation H1-antihistamines, compared with their first-generation counterparts, have demonstrated improved peripheral H1-receptor selectivity and decreased lipophilicity (which minimizes CNS adverse effects), and antiallergic properties in addition to being histamine inverse agonists. Evidence of clinical efficacy and tolerability of second-generation H1-antihistamines available in the US for the treatment of chronic urticaria (CU) was analyzed using the GRADE system to develop the strength of recommendations for particular therapies. The evidence for the safety and efficacy of the majority of second-generation H1-antihistamines available in the US is of high quality and leads to a strong recommendation for their use in CU. There is a limited amount of data of variable quality comparing the efficacy between various second-generation H1-antihistamines in CU leading to weak recommendations for using cetirizine over fexofenadine and levocetirizine over desloratadine. Limited data of variable quality exist for the efficacy of higher doses of second-generation H1-antihistamines in CU patients not responsive to standard doses. These limited data lead to a strong recommendation that higher than recommended doses of fexofenadine do not offer greater efficacy in control of CU and a weak recommendation that higher doses of levocetirizine and desloratadine are more effective in CU unresponsive to standard doses. More studies of higher quality are required to make any firm recommendations regarding second-generation H1-antihistamines in the treatment of physical urticarias. All second-generation H1-antihistamines appear to be very well tolerated in CU patients, with rare reports of adverse effects. Due to the relatively large gaps in the quantity and quality of evidence, particularly for choice of H1-antihistamines, use of higher doses

  7. Établir le bien-fondé du libre accès à la recherche | CRDI - Centre ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    « La recherche devrait être un bien public », affirme Erika Malich, titulaire d'une bourse de recherche du CRDI en 2016. « Peu importe à quel point elle est rigoureuse et peu importe l'importance des conclusions, la recherche ne parle pas d'elle-même. »

  8. Avenir de la recherche scientifique en entrepreneuriat en Allemagne - Stratégies et principaux points thématiques

    NARCIS (Netherlands)

    Grichnik, Dietmar; Harms, Rainer

    2008-01-01

    La recherche en entrepreneuriat continue à évoluer. Ce champ de recherche qui va de l'interprétation de la nature du champ à la signification accordée à chaque thématique est soumis à des changements. Tenter de brosser un portrait de l'évolution de la recherche en entrepreneuriat en Allemagne

  9. Inelastic incoherent neutron scattering spectra from fcc NiH 1.05, hcp CrH 1.0 and hcp MoH 1.2 at 15K

    Science.gov (United States)

    Dorner, B.; Belash, I. T.; Bokhenkov, E. L.; Ponyatovsky, E. G.; Antonov, V. E.; Pronina, L. N.

    1989-01-01

    Inelastic incoherent neutron scattering spectra from nickel, chromium and molybdenum hydrides, synthesized under high pressure of gaseous hydrogen, have been obtained in the energy region of optical modes of hydrogen vibrations. The measurements have been carried out at the three-axis spectrometer IN1 on the hot source of the ILL High Flux Reactor with the Beryllium filter-detector technique. In all three cases the frequencies of the fundamental vibrations scale to the observed higher harmonics as 1:2:3. The spectra exhibit a fine structure around the fundamentals as well as around the harmonics. Possible reasons for this effect are discussed.

  10. Noble Gas Detectors

    CERN Document Server

    Aprile, Elena; Bolozdynya, Alexander I; Doke, Tadayoshi

    2006-01-01

    This book discusses the physical properties of noble fluids, operational principles of detectors based on these media, and the best technical solutions to the design of these detectors. Essential attention is given to detector technology: purification methods and monitoring of purity, information readout methods, electronics, detection of hard ultra-violet light emission, selection of materials, cryogenics etc.The book is mostly addressed to physicists and graduate students involved in the preparation of fundamental next generation experiments, nuclear engineers developing instrumentation

  11. Phase 1 study of pandemic H1 DNA vaccine in healthy adults.

    Directory of Open Access Journals (Sweden)

    Michelle C Crank

    Full Text Available A novel, swine-origin influenza A (H1N1 virus was detected worldwide in April 2009, and the World Health Organization (WHO declared a global pandemic that June. DNA vaccine priming improves responses to inactivated influenza vaccines. We describe the rapid production and clinical evaluation of a DNA vaccine encoding the hemagglutinin protein of the 2009 pandemic A/California/04/2009(H1N1 influenza virus, accomplished nearly two months faster than production of A/California/07/2009(H1N1 licensed monovalent inactivated vaccine (MIV.20 subjects received three H1 DNA vaccinations (4 mg intramuscularly with Biojector at 4-week intervals. Eighteen subjects received an optional boost when the licensed H1N1 MIV became available. The interval between the third H1 DNA injection and MIV boost was 3-17 weeks. Vaccine safety was assessed by clinical observation, laboratory parameters, and 7-day solicited reactogenicity. Antibody responses were assessed by ELISA, HAI and neutralization assays, and T cell responses by ELISpot and flow cytometry.Vaccinations were safe and well-tolerated. As evaluated by HAI, 6/20 developed positive responses at 4 weeks after third DNA injection and 13/18 at 4 weeks after MIV boost. Similar results were detected in neutralization assays. T cell responses were detected after DNA and MIV. The antibody responses were significantly amplified by the MIV boost, however, the boost did not increased T cell responses induced by DNA vaccine.H1 DNA vaccine was produced quickly, was well-tolerated, and had modest immunogenicity as a single agent. Other HA DNA prime-MIV boost regimens utilizing one DNA prime vaccination and longer boost intervals have shown significant immunogenicity. Rapid and large-scale production of HA DNA vaccines has the potential to contribute to an efficient response against future influenza pandemics.Clinicaltrials.gov NCT00973895.

  12. [Influenza H1N1 in obstetric population of a general hospital in Oaxaca].

    Science.gov (United States)

    Calvo Aguilar, Omar; Canalizo Mendoza, Yazmín Ruth; Hernández Cuevas, Maritza Jenny

    2011-06-01

    In April 2009 are reported the first cases of H1N1 influenza in Mexico, presenting the first death from this cause in the city of Oaxaca in the same month. Different epidemiological reports of pandemics brought to the pregnant and high risk population for complications secondary to infection with influenza H1N1 due to immune status. describe the obstetric population infected with H1N1 influenza in the Hospital General Dr. Aurelio Valdivieso of Oaxaca. Retrospective and observational study conducted in pregnant women with suspected infection by the virus of the influenza A/H1N1 served in the General Hospital Aurelio Valdivieso of Oaxaca, Oax in 13 patients with influenza H1N1 confirmed by RT-PCR during the pandemic occurred from May 2009 to April 2010. We reported 27 suspected cases of H1N1 influenza in pregnant women of which 13 were positive by RT-PCR, the cumulative incidence was 1.6 per 1000 pregnant women during the period. The fatality rate was 7.6 per hundred pregnant women affected, one case of maternal death indirectly by fluid and electrolyte imbalance occurred and the attack rate was 0.16 per 100 pregnant women, the main complication of atypical pneumonia occurred in four cases followed by three cases of preeclampsia, infants showed no defects and perinatal outcomes were good to present two cases of admission to the NICU for iatrogenic prematurity without deaths. H1N1 influenza infection has a high fatality rate in late pregnancy. Perinatal outcomes did not worsen the condition or management.

  13. Pandemic influenza (H1N1 2009 is associated with severe disease in India.

    Directory of Open Access Journals (Sweden)

    Akhilesh C Mishra

    Full Text Available BACKGROUND: Pandemic influenza A (H1N1 2009 has posed a serious public health challenge world-wide. In absence of reliable information on severity of the disease, the nations are unable to decide on the appropriate response against this disease. METHODS: Based on the results of laboratory investigations, attendance in outpatient department, hospital admissions and mortality from the cases of influenza like illness from 1 August to 31 October 2009 in Pune urban agglomeration, risk of hospitalization and case fatality ratio were assessed to determine the severity of pandemic H1N1 and seasonal influenza-A infections. RESULTS: Prevalence of pandemic H1N1 as well as seasonal-A cases were high in Pune urban agglomeration during the study period. The cases positive for pandemic H1N1 virus had significantly higher risk of hospitalization than those positive for seasonal influenza-A viruses (OR: 1.7. Of 93 influenza related deaths, 57 and 8 deaths from Pune (urban and 27 and 1 death from Pune (rural were from pandemic H1N1 positive and seasonal-A positive cases respectively. The case fatality ratio 0.86% for pandemic H1N1 was significantly higher than that of seasonal-A (0.13% and it was in category 3 of the pandemic severity index of CDC, USA. The data on the cumulative fatality of rural and urban Pune revealed that with time the epidemic is spreading to rural areas. CONCLUSIONS: The severity of the H1N1 influenza pandemic is less than that reported for 'Spanish flu 1918' but higher than other pandemics of the 20(th century. Thus, pandemic influenza should be considered as serious health threat and unprecedented global response seems justified.

  14. Clinical profile and outcome of critically ill pregnant females with H1N1 influenza

    Directory of Open Access Journals (Sweden)

    Minal Shastri

    2016-12-01

    Full Text Available Background Record based review of the 2009 H1N1 Influenza pandemic suggests that pregnant women are at higher risk for hospitalization and death due to H1N1 Influenza. Aims To study the clinical profile and outcome of critically ill pregnant females admitted in intensive care unit (ICU with real-time recombinant polymerase chain reaction (rRT-PCR proven positive H1N1 cases. Methods A retrospective record-review based study was conducted at Sir SayajiRao General Hospital (SSGH and Medical College, Vadodara on data of confirmed rRT-PCR H1N1 pregnant females admitted during the pandemics of 2010and 2015. Demographics, clinical profile and laboratory investigations were recorded and outcomes (survived or expired were analysed. Results There were a total of 20 H1N1 positive pregnant females requiring ICU admission. With equal demographic distribution among rural and urban population, cough and fever were the most common presenting complaints. 65 per cent were in third trimester, the subgroup which also had the highest mortality. Mean days from onset until presentation was 5.05 days. 12 (60 per cent patients’ required invasive mode of ventilation and all died. Average hospital stay was 7 days. Foetus had favourable outcome in patients who recovered from H1N1 acute illness. Conclusion Pregnant females in our study had 60 per cent mortality. Thus, awareness, early diagnosis and treatment should be provided to them. Guidelines, policy changes and government protocols are required specifically for pregnant females with H1N1 Influenza A infection. Our study was an observational study and comparisons with non-pregnant females were not done, conclusions applicable to entire pregnant population was not derived.

  15. The LHC detector challenge

    CERN Document Server

    Virdee, Tejinder S

    2004-01-01

    The Large Hadron Collider (LHC) from CERN, scheduled to come online in 2007, is a multi-TeV proton-proton collider with vast detectors. Two of the more significant detectors for LHC are ATLAS and CMS. Currently, both detectors are more than 65% complete in terms of financial commitment, and the experiments are being assembled at an increasing pace. ATLAS is being built directly in its underground cavern, whereas CMS is being assembled above ground. When completed, both detectors will aid researchers in determining what lies at the high-energy frontier, in particular the mechanism by which particles attain mass. (Edited abstract).

  16. ALFA Detector Control System

    CERN Document Server

    Oleiro Seabra, Luis Filipe; The ATLAS collaboration

    2015-01-01

    ALFA (Absolute Luminosity For ATLAS) is one of the sub-detectors of ATLAS/LHC. The ALFA system is composed by two stations installed in the LHC tunnel 240 m away from each side of the ATLAS interaction point. Each station has a vacuum and ventilation system, movement control and all the required electronic for signal processing. The Detector Control System (DCS) provides control and monitoring of several components and ensures the safe operation of the detector contributing to good Data Quality. This paper describes the ALFA DCS system including a detector overview, operation aspects and hardware control through a SCADA system, WinCC OA.

  17. LHCb Detector Performance

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreassen, Rolf; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Belogurov, Sergey; Belous, Konstantin; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Bizzeti, Andrea; Bjørnstad, Pål Marius; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borgia, Alessandra; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Brambach, Tobias; Bressieux, Joël; Brett, David; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Brook, Nicholas; Brown, Henry; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Ciba, Krzystof; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cogoni, Violetta; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Counts, Ian; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Crocombe, Andrew; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pascal; David, Pieter; Davis, Adam; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Di Canto, Angelo; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dreimanis, Karlis; Dujany, Giulio; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farley, Nathanael; Farry, Stephen; Fay, Robert; Ferguson, Dianne; Fernandez Albor, Victor; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fol, Philip; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; García Pardiñas, Julián; Garofoli, Justin; Garra Tico, Jordi; Garrido, Lluis; Gascon, David; Gaspar, Clara; Gauld, Rhorry; Gavardi, Laura; Geraci, Angelo; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Gianì, Sebastiana; Gibson, Valerie; Giubega, Lavinia-Helena; Gligorov, V.V.; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graverini, Elena; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Hunt, Philip; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jaton, Pierre; Jawahery, Abolhassan; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Karodia, Sarah; Kelsey, Matthew; Kenyon, Ian; Ketel, Tjeerd; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Klimaszewski, Konrad; Kochebina, Olga; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kozlinskiy, Alexandr; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leo, Sabato; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Lohn, Stefan; Longstaff, Iain; Lopes, Jose; Lopez-March, Neus; Lowdon, Peter; Lucchesi, Donatella; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Machikhiliyan, Irina V; Maciuc, Florin; Maev, Oleg; Malde, Sneha; Malinin, Alexander; Manca, Giulia; Mancinelli, Giampiero; Mapelli, Alessandro; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martens, Aurelien; Martín Sánchez, Alexandra; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massafferri, André; Matev, Rosen; Mathe, Zoltan; Matteuzzi, Clara; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; McSkelly, Ben; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Moggi, Niccolò; Molina Rodriguez, Josue; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Katharina; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Nicol, Michelle; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Oggero, Serena; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Orlandea, Marius; Otalora Goicochea, Juan Martin; Owen, Patrick; Oyanguren, Maria Arantza; Pal, Bilas Kanti; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parkes, Christopher; Parkinson, Christopher John; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Perrin-Terrin, Mathieu; Pescatore, Luca; Pesen, Erhan; Pessina, Gianluigi; Petridis, Konstantin; Petrolini, Alessandro; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Playfer, Stephen; Plo Casasus, Maximo; Polci, Francesco; Poluektov, Anton; Polyakov, Ivan; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rama, Matteo; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruiz, Hugo; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skillicorn, Ian; Skwarnicki, Tomasz; Smith, Anthony; Smith, Edmund; Smith, Eluned; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Sparkes, Ailsa; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Steinkamp, Olaf; Stenyakin, Oleg; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Stroili, Roberto; Subbiah, Vijay Kartik; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szumlak, Tomasz; T'Jampens, Stephane; Teklishyn, Maksym; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Tran, Minh Tâm; Tresch, Marco; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ubeda Garcia, Mario; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Whitehead, Mark; Wicht, Jean; Wiedner, Dirk; Wilkinson, Guy; Williams, Matthew; Williams, Mike; Wilschut, Hans; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wyllie, Kenneth; Xie, Yuehong; Xing, Zhou; Xu, Zhirui; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Wen Chao; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang; Zvyagin, Alexander

    2015-03-05

    The LHCb detector is a forward spectrometer at the Large Hadron Collider (LHC) at CERN. The experiment is designed for precision measurements of CP violation and rare decays of beauty and charm hadrons. In this paper the performance of the various LHCb sub-detectors and the trigger system are described, using data taken from 2010 to 2012. It is shown that the design criteria of the experiment have been met. The excellent performance of the detector has allowed the LHCb collaboration to publish a wide range of physics results, demonstrating LHCb's unique role, both as a heavy flavour experiment and as a general purpose detector in the forward region.

  18. ALFA Detector Control System

    CERN Document Server

    Oleiro Seabra, Luis Filipe; The ATLAS collaboration

    2015-01-01

    ALFA (Absolute Luminosity For ATLAS) is one of the sub-detectors of ATLAS (A Toroidal LHC Apparatus). The ALFA system is composed by four stations installed in the LHC tunnel 240 m away from the ATLAS interaction point. Each station has a vacuum and ventilation system, movement control and all the required electronics for signal processing. The Detector Control System (DCS) provides control and monitoring of several components and ensures the safe operation of the detector contributing to good Data Quality. This paper describes the ALFA DCS system including a detector overview, operation aspects and hardware control through a SCADA system, WinCC OA.

  19. Gestion du risque et audit | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'innovation va de pair avec le risque, peu importe où la recherche a lieu. Puisque bon nombre de nos projets sont en place dans certains des pays les plus pauvres au monde, le CRDI fait souvent face à un autre niveau de risque, comme une faible infrastructure de recherche, des établissements fragiles, ainsi que des ...

  20. La recherche en écosanté en pratique : Applications novatrices d ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La recherche en écosanté en pratique : Applications novatrices d'une approche écosystémique de la santé. Couverture du livre La recherche en écosanté en pratique : Applications novatrices d'une approche. Directeur(s) : Dominique F. Charron. Maison(s) d'édition : Springer, CRDI. 28 juin 2014. ISBN : 9781461452805.