Recent progress in fusion gyrotron development

International Nuclear Information System (INIS)

Shively, J.F.; Stone, D.S.

1981-01-01

The gyrotron, a microwave tube capable of producing high power output at millimeter wavelengths, has recently found applications for electron cyclotron resonance heating of plasmas in controlled thermonuclear fusion reactor experiments. This paper describes work in progress to develop a gyrotron oscillator to deliver 200 kW CW at 60 GHz (/lambda/sub //. 5 mm). A pulsed oscillator is described which produced over 200 kw peak power. A CW oscillator is under construction. The latest experimental results are presented

Gyrotrons

International Nuclear Information System (INIS)

Ebrahim, N.A.

1987-05-01

The purpose of this study is to bring together some relevant ideas and developments in the field of gyrotrons. The development of the electron cyclotron resonance maser (ECRM or Gyrotron) was an important break through in microwave electronics in the 1970s. As we look to the 1980's, we find scientists channelling their collective efforts to shorten the wavelength and increase output power and efficiency, thereby yielding an important device for generating high power microwave radiation. 24 refs

Update on the DIII-D ECH system: experiments, gyrotrons, advanced diagnostics, and controls

Directory of Open Access Journals (Sweden)

Lohr John

2017-01-01

Full Text Available The ECH system on DIII-D is continuing to be upgraded, while simultaneously being operated nearly daily for plasma experiments. The latest major hardware addition is a new 117.5 GHz gyrotron, which generated 1.7 MW for short pulses during factory testing. A new gyrotron control system based on Field Programmable Gate Array (FPGA technology with very high speed system data acquisition has significantly increased the flexibility and reliability of individual gyrotron operation. We have improved the performance of the fast mirror scanning, both by increasing the scan speeds and by adding new algorithms for controlling the aiming using commands generated by the Plasma Control System (PCS. The system is used for transport studies, ELM control, current profile control, non-inductive current generation, suppression of MHD modes, startup assist, plasma density control, and other applications. A program of protective measures, which has been in place for more than two years, has eliminated damage to hardware and diagnostics caused by overdense operation. Other activities not directly related to fusion research have used the ECH system to test components, study methods for improving production of semiconductor junctions and materials, and test the feasibility of using ground based microwave systems to power satellites into orbit.

Update on the DIII-D ECH system: experiments, gyrotrons, advanced diagnostics, and controls

Science.gov (United States)

Lohr, John; Brambila, Rigoberto; Cengher, Mirela; Gorelov, Yuri; Grosnickle, William; Moeller, Charles; Ponce, Dan; Torrezan, Antonio; Ives, Lawrence; Reed, Michael; Blank, Monica; Felch, Kevin; Parisuaña, Claudia; LeViness, Alexandra

2017-08-01

The ECH system on DIII-D is continuing to be upgraded, while simultaneously being operated nearly daily for plasma experiments. The latest major hardware addition is a new 117.5 GHz gyrotron, which generated 1.7 MW for short pulses during factory testing. A new gyrotron control system based on Field Programmable Gate Array (FPGA) technology with very high speed system data acquisition has significantly increased the flexibility and reliability of individual gyrotron operation. We have improved the performance of the fast mirror scanning, both by increasing the scan speeds and by adding new algorithms for controlling the aiming using commands generated by the Plasma Control System (PCS). The system is used for transport studies, ELM control, current profile control, non-inductive current generation, suppression of MHD modes, startup assist, plasma density control, and other applications. A program of protective measures, which has been in place for more than two years, has eliminated damage to hardware and diagnostics caused by overdense operation. Other activities not directly related to fusion research have used the ECH system to test components, study methods for improving production of semiconductor junctions and materials, and test the feasibility of using ground based microwave systems to power satellites into orbit.

Operations Studies of the Gyrotrons on DIII-D

Science.gov (United States)

Storment, Stephen; Lohr, John; Cengher, Mirela; Gorelov, Yuri; Ponce, Dan; Torrezan, Antonio

2017-10-01

The gyrotrons are high power vacuum tubes used in fusion research to provide high power density heating and current drive in precisely localized areas of the plasma. Despite the increasing experience with both the manufacture and operation of these devices, individual gyrotrons with similar design and manufacturing processes can exhibit important operational differences in terms of generated rf power, efficiency and lifetime. This report discusses differences in the performance of several gyrotrons in operation at DIII-D and presents the results of a series of measurements that could lead to improved the performance of single units based on a better understanding of the causes of these differences. The rf power generation efficiency can be different from gyrotron to gyrotron. In addition, the power loading of the collector can feature localized hot spots, where the collector can locally be close to the power deposition limits. Measurements of collector power loading provide maps of the power deposition and can provide understanding of the effect of modulation of the output rf beam on the total loading, leading to improved operational rules increasing the safety margins for the gyrotrons under different operational scenarios. Work supported by US DOE under DE-FC02-04ER54698.

The Use of a 28 GHz Gyrotron for EBW Startup Experiments on MAST

Science.gov (United States)

Caughman, J. B.; Bigelow, T. S.; Diem, S. J.; Peng, Y. K. M.; Rasmussen, D. A.; Shevchenko, V.; Hawes, J.; Lloyd, B.

2009-11-01

The use of electron Bernstein waves for non-inductive plasma current startup in MAST has recently been demonstrated [1]. The injection of 100 kW at 28 GHz generated plasma currents of up to 33 kA without the use of solenoid flux, and limited solenoid assist resulted in up to 55 kA of plasma current. A higher power 28 GHz gyrotron, with power levels of up to 300 kW for 0.5 seconds, is currently being commissioned. It is being used to investigate the scaling of startup current with microwave power and power profile as a function of time. Power modulation experiments are also being explored. Gyrotron performance and experimental results will be presented. [4pt] [1] V. Shevchenko, et al., Proceedings of the 15^th Joint Workshop on ECE and ECRH, Yosimite, USA, p. 68 (2009)

Development of gyrotrons for plasma diagnostics (invited)

International Nuclear Information System (INIS)

Woskoboinikow, P.

1986-01-01

Recent advances in high-frequency (>100 GHz) gyrotron technology are reviewed and application to millimeter/submillimeter wave plasma diagnostics is discussed. Gyrotrons have useful capabilities of high-power (>1 kW), long pulse/cw operation, narrow linewidth (<100 kHz), and good spatial mode quality with efficient (--90%) mode converters. These capabilities could be used to significantly improve collective Thomson scattering diagnostics for the study of instabilities, plasma waves, turbulence, and thermal ion fluctuations. Imaging applications with many detector arrays of plasma density, field direction, and microinstabilities may be possible with gyrotons. In a high-field compact ignition tokamak experiment a possible millimeter wave diagnostics window could be exploited by a gyrotron to measure a number of parameters, including alpha particle density and velocity distribution

A 2 MW, CW, 170 GHz gyrotron for ITER

International Nuclear Information System (INIS)

Piosczyk, B.; Arnold, A.; Alberti, S.

2003-01-01

A 140 GHz gyrotron for CW operation is under development for the stellarator W7-X. With a prototype tube a microwave output power of about 0.9 MW has been obtained in pulses up to 180 s, limited by the capability of the high voltage power supply. The development work on coaxial cavity gyrotrons has demonstrated the feasibility of manufacturing of a 2 MW, CW 170 GHz tube that could be used for ITER. The problems specific to the coaxial arrangement have been investigated and all relevant information needed for an industrial realization of a coaxial gyrotron have been obtained in short pulse experiments (up to 17 ms). The suitability of critical components for a 2 MW, CW coaxial gyrotron has been studied and a first integrated design has been done. (author)

Experimental investigation of plasma-neutralized operation of a gyrotron

International Nuclear Information System (INIS)

Kirkpatrick, D.A.; Sullivan, C.; Gold, S.H.; Manheimer, W.M.; Levush, B.; Antonsen, T.M.

1989-01-01

The authors present plans and preliminary results of an experiment to investigate the effects of a neutralizing background plasma on the operation of a gyrotron oscillator. Previous experiments operating without a neutralizing background plasma achieved output powers P = 100 - 250MW at a frequency f = 35 GHz, with beam voltages in the range V = 0.60 - 1.35MV, and beam currents I = 1 -3kA. A completely ionized plasma is injected into a gyrotron interaction region from an upstream array of plasma guns. The peak plasma density available from the plasma guns exceeds n p > 10 13 cm -3 . The plasma density is measured by 70 GHz microwave interferometry and Langmuir probes. A high current electron beam from a field emission electron gun enters the plasma-filled gyrotron cavity from the upstream side. The density of the neutralizing plasma is varied by changing the delay between the firing of plasma guns and the VEBA accelerator. The authors present measurements of the transmitted electron beam current. Subsequent design of a gyrotron oscillator which utilizes the enhanced capabilities are presented

ITER ECFR Coaxial gyrotron and window development (EU-T360). Pt. 1: Coaxial gyrotron development. Final report

International Nuclear Information System (INIS)

Piosczyk, B.; Braz, O.; Dammertz, G.; Kuntze, G.; Michel, G.; Moebius, A.; Thumm, M.

1999-02-01

Based on the experience gained with the inverse magnetron injection gun (IMIG) for coaxial cavity gyrotrons, a new 4.5 MW electron gun for operation at a cathode voltage of 90 kV and a beam current of 50 A has been designed and is currently under fabrication at Thomson Tubes Electroniques (TTE). The gun is of the diode type. Different from the LaB 6 IMIG currently used, the emission of the electrons will not be directed towards the coaxial insert but towards the anode similar like in conventional MIG gyrotron electron guns. The inner conductor is supported from the gun inner conductor side and can be aligned in a reproducible way in the fully assembled tube. The insert is cooled as required for operation at long pulses up to cw. The cathode will be equipped with an impregnated tungsten matrix emitter as used in industrial tubes. A 160/170 GHz, 1.5 MW, 100 ms pulse length coaxial gyrotron employing the new electron gun and a single-stage depressed collector has been designed. The advanced quasi-optical converter for transforming the TE -31,17 cavity mode at 165 GHz into a single RF-output wave beam (only one output window) consists of a simple launcher and two mirrors. The first mirror is quasi-elliptical and the second mirror has a non-quadratic phase-correcting surface to generate an approximately homogeneous RF-field distribution with a high fundamental Gaussian content in the window plane. First test experiments with the new gyrotron have been performed employing the available LaB 6 -IMIG. (orig.)

Thermal analysis of gyrotron traveling-wave tube collector

International Nuclear Information System (INIS)

Zheng Zhiqing; Luo Yong; Jiang Wei; Tang Yong

2013-01-01

In order to solve cooling problem of the gyrotron traveling-wave tube(TWT) collector and guarantee the gyrotron TWT's reliability and stability, the electron trajectories in the gyrotron TWT are simulated using CST electron simulation software. Thermal analysis of the collector with finite element software ANSYS is performed. The ways of applying boundary that affects the distribution of collector temperature are compared. The influence of the water temperature and flow rate on collector temperature distribution under actual heat fluxes (boundary condition) is researched. The size and number of collector fins are optimized, and a relatively perfect structure is obtained finally. The result estimated by simulation is consistent with the experiment and proves that the model and method employed in this work are suitable. (authors)

First 200 kW CW operation of a 60 GHz gyrotron

International Nuclear Information System (INIS)

Jory, H.; Bier, R.; Evans, S.; Felch, K.; Fox, L.; Huey, H.; Shively, J.; Spang, S.

1983-01-01

The gyrotron is a microwave tube which employs the electron cyclotron maser interaction to produce high power output at millimeter wavelengths. It has important and growing applications for heating of plasmas in controlled thermonuclear fusion experiments. The Varian 60 GHz gyrotron has recently generated microwave power in excess of 200 kW during CW operation, wth excellent dynamic range and operating stability. This is the highest average power ever produced by a microwave tube in the millimeter wave region. A description of the gyrotron design and test results are presented

Velocity diagnostics of electron beams within a 140 GHz gyrotron

International Nuclear Information System (INIS)

Polevoy, J.T.

1989-06-01

Experimental measurements of the average axial velocity v parallel of the electron beam within the M.I.T. 140 GHz MW gyrotron have been performed. The method involves the simultaneous measurement of the radial electrostatic potential of the electron beam V p and the beam current I b . V p is measured through the use of a capacitive probe installed near or within the gyrotron cavity, while I b is measured with a previously installed Rogowski coil. Three capacitive probes have been designed and built, and two have operated within the gyrotron. The probe results are repeatable and consistent with theory. The measurements of v parallel and calculations of the corresponding transverse to longitudinal beam velocity ratio α = v perpendicular /v parallel at the cavity have been made at various gyrotron operation parameters. These measurements will provide insight into the causes of discrepancies between theoretical rf interaction efficiencies and experimental efficiencies obtained in experiments with the M.I.T. 140 GHz MW gyrotron. The expected values of v parallel and α are determined through the use of a computer code entitled EGUN. EGUN is used to model the cathode and anode regions of the gyrotron and it computes the trajectories and velocities of the electrons within the gyrotron. There is good correlation between the expected and measured values of α at low α, with the expected values from EGUN often falling within the standard errors of the measured values. 10 refs., 29 figs., 2 tabs

Experimental measurements on a 100 GHz frequency tunable quasioptical gyrotron

International Nuclear Information System (INIS)

Alberti, S.; Tran, M.Q.; Hogge, J.P.; Tran, T.M.; Bondeson, A.; Muggli, P.; Perrenoud, A.; Joedicke, B.; Mathews, H.G.

1990-01-01

Experiments on a 100 GHz quasioptical (QO) gyrotron operating at the fundamental (ω=Ω ce ) are described. Powers larger than 90 kW at an efficiency of about 12% were achieved. Depending on the electron beam parameters, the frequency spectrum of the output can be either single moded or multimoded. One of the main advantages of the QO gyrotron over the conventional gyrotron is its continuous frequency tunability. Various techniques to tune the output frequency have been tested, such as changing the mirror separation, the beam voltage, or the main magnetic field. Within the limitations of the present setup, 5% tunability was achieved. The QO gyrotron designed for operation at the fundamental frequency exhibits simultaneous emission at 100 GHz (fundamental) and 200 GHz (second harmonic). For a beam current of 4 A, 20% of the total rf power is emitted at the second harmonic

Development of field simulator to test and qualify the gyrotron local control unit for ITER-India Gyrotron Test Facility

International Nuclear Information System (INIS)

Shah, Ronak; Mandge, Deepak; Rathod, Vipal; Parmar, Rajvi; Dilip, E. Sharan; Yadav, Amit; Sharma, Anjali; Rao, S.L.

2017-01-01

High power RF sources such as a Gyrotron system are operated at required output parameter by using various auxiliary power supplies, High voltage power supplies, auxiliary services and a dedicated Local Control Unit (LCU). These sub-systems must be operated in synchronous and safe way to control the gyrotron output parameters. The LCU performs remote, synchronous and safe operation of the all the gyrotron sub-systems. Broadly the LCU functions are operational control, data acquisition, protection and safety of the gyrotron system. At ITER-India gyrotron Test Facility (IIGTF) a local control unit (LCU) is being developed to operate the complete gyrotron system. This paper presents the design, development and various features of the field simulator. It also discuss LCU functionality test cases and results obtained using field simulator

Velocity diagnostics of electron beams within a 140 GHz gyrotron

Science.gov (United States)

Polevoy, Jeffrey Todd

1989-06-01

Experimental measurements of the average axial velocity v(sub parallel) of the electron beam within the M.I.T. 140 GHz MW gyrotron have been performed. The method involves the simultaneous measurement of the radial electrostatic potential of the electron beam V(sub p) and the beam current I(sub b). The V(sub p) is measured through the use of a capacitive probe installed near or within the gyrotron cavity, while I(sub b) is measured with a previously installed Rogowski coil. Three capacitive probes have been designed and built, and two have operated within the gyrotron. The probe results are repeatable and consistent with theory. The measurements of v(sub parallel) and calculations of the corresponding transverse to longitudinal beam velocity ratio (alpha) = v(sub perpendicular)/v(sub parallel) at the cavity have been made at various gyrotron operation parameters. These measurements will provide insight into the causes of discrepancies between theoretical RF interaction efficiencies and experimental efficiencies obtained in experiments with the M.I.T. 140 GHz MW gyrotron. The expected values of v(sub parallel) and (alpha) are determined through the use of a computer code (EGUN) which is used to model the cathode and anode regions of the gyrotron. It also computes the trajectories and velocities of the electrons within the gyrotron. There is good correlation between the expected and measured values of (alpha) at low (alpha), with the expected values from EGUN often falling within the standard errors of the measured values.

High Power Microwave Emission of Large and Small Orbit Gyrotron Devices in Rectangular Interaction Structures

Science.gov (United States)

Hochman, J. M.; Gilgenbach, R. M.; Jaynes, R. L.; Rintamaki, J. I.; Luginsland, J. W.; Lau, Y. Y.; Spencer, T. A.

1996-11-01

Experiments utilize large and small orbit e-beam gyrotron devices in a rectangular-cross-section (RCS) gyrotron. This device is being explored to examine polarization control. Other research issues include pulse shortening, and mode competition. MELBA generates electron beams with parameters of: -800kV, 1-10kA diode current, and 0.5-1.0 μ sec pulselengths. The small orbit gyrotron device is converted to a large orbit experiment by running MELBA's annular electron beam through a magnetic cusp. Initial experiments showed an increase in beam alpha (V_perp/V_par) of a factor of ~ 4 between small and large orbit devices. Experimental results from the RCS gyrotron will be compared for large-orbit and small-orbit electron beams. Beam transport data and frequency measurements will be presented. Computer modeling utilizing the MAGIC and E-gun codes will be shown.

Gyrotron: an ECH system component

International Nuclear Information System (INIS)

Loring, C.M.; Eason, H.O.; Kimrey, H.D.; White, T.L.; Jory, H.R.; Evans, S.J.

1981-01-01

The gyrotron, or electron-cyclotron maser, in the form of a gyromonotron, is being developed as a source of millimeter wave energy for fusion plasma heating. The characteristics of this high power, high efficiency electron tube are described in terms of the requirements for the beam power supply system, the mechanical support system, the cooling system, the focusing and tuning magnets, and the waveguide system. Requirements of power level and transmission efficiency dictate the use of oversize waveguide. The implications, both to the user and to the interaction mechanisms in the gyrotron, of the use of oversize waveguide are treated. The effects of variations of various operating parameters upon the gyrotron's power output and stability are also discussed. Data from gyrotron development and system operation are used where appropriate

Development of frequency tunable gyrotrons for plasma diagnostics

International Nuclear Information System (INIS)

Idehara, T.; Mitsudo, S.; Sabchevski, S.; Glyavin, M.; Ogawa, I.; Sato, M.; Kawahata, K.; Brand, G.F.

2000-01-01

Development of two types of frequency tunable gyrotrons are described. One is frequency step-tunable gyrotrons (Gyrotron FU Series) which cover wide range from millimeter to submillimeter wavelength region. The other is a quasi-optical gyrotron operating in 90 and 180 GHz bands. Both are applicable for plasma diagnostics as power sources. (author)

Gyrotrons for fusion. Status and prospects

International Nuclear Information System (INIS)

Litvak, A.G.; Alikaev, V.V.; Denisov, G.G.; Kurbatov, V.I.; Myasnikov, V.E.; Tai, E.M.; Zapevalov, V.E.

2001-01-01

Gyrotrons are the most advanced high-power sources of millimeter wavelength radiation. They have been used for many years in electron-cyclotron-wave (ECW) systems of many existing fusion installations. Typically modern gyrotrons produce power of 0.5...0.8 MW in pulses of 2-3 seconds, or lower power in longer pulses (e.g. 300-400 kW in pulses up to 10-15 seconds). For the next generation of fusion installations, such as ITER or W7-X the ECW systems based on gyrotrons capable to produce 1MW/CW radiation are considered. Definitely, such gyrotrons with enhanced performance are very interesting also for the use also at existing installations

High resolution observed in 800 MHz DNP spectra of extremely rigid type III secretion needles

International Nuclear Information System (INIS)

Fricke, Pascal; Mance, Deni; Chevelkov, Veniamin; Giller, Karin; Becker, Stefan; Baldus, Marc; Lange, Adam

2016-01-01

The cryogenic temperatures at which dynamic nuclear polarization (DNP) solid-state NMR experiments need to be carried out cause line-broadening, an effect that is especially detrimental for crowded protein spectra. By increasing the magnetic field strength from 600 to 800 MHz, the resolution of DNP spectra of type III secretion needles (T3SS) could be improved by 22 %, indicating that inhomogeneous broadening is not the dominant effect that limits the resolution of T3SS needles under DNP conditions. The outstanding spectral resolution of this system under DNP conditions can be attributed to its low overall flexibility.

High resolution observed in 800 MHz DNP spectra of extremely rigid type III secretion needles

Energy Technology Data Exchange (ETDEWEB)

Fricke, Pascal [Leibniz-Institut für Molekulare Pharmakologie, Department of Molecular Biophysics (Germany); Mance, Deni [Utrecht University, NMR Research Group, Bijvoet Center for Biomolecular Research (Netherlands); Chevelkov, Veniamin [Leibniz-Institut für Molekulare Pharmakologie, Department of Molecular Biophysics (Germany); Giller, Karin; Becker, Stefan [Max Planck Institute for Biophysical Chemistry, Department of NMR-Based Structural Biology (Germany); Baldus, Marc [Utrecht University, NMR Research Group, Bijvoet Center for Biomolecular Research (Netherlands); Lange, Adam, E-mail: alange@fmp-berlin.de [Leibniz-Institut für Molekulare Pharmakologie, Department of Molecular Biophysics (Germany)

2016-08-15

The cryogenic temperatures at which dynamic nuclear polarization (DNP) solid-state NMR experiments need to be carried out cause line-broadening, an effect that is especially detrimental for crowded protein spectra. By increasing the magnetic field strength from 600 to 800 MHz, the resolution of DNP spectra of type III secretion needles (T3SS) could be improved by 22 %, indicating that inhomogeneous broadening is not the dominant effect that limits the resolution of T3SS needles under DNP conditions. The outstanding spectral resolution of this system under DNP conditions can be attributed to its low overall flexibility.

High power gyrotrons: a close perspective

International Nuclear Information System (INIS)

Kartikeyan, M.V.

2012-01-01

Gyrotrons and their variants, popularly known as gyrodevices are millimetric wave sources provide very high powers ranging from long pulse to continuous wave (CW) for various technological, scientific and industrial applications. From their conception (monotron-version) in the late fifties until their successful development for various applications, these devices have come a long way technologically and made an irreversible impact on both users and developers. The possible applications of high power millimeter and sub-millimeter waves from gyrotrons and their variants (gyro-devices) span a wide range of technologies. The plasma physics community has already taken advantage of the recent advances of gyrotrons in the areas of RF plasma production, heating, non-inductive current drive, plasma stabilization and active plasma diagnostics for magnetic confinement thermonuclear fusion research, such as lower hybrid current drive (LHCD) (8 GHz), electron cyclotron resonance heating (ECRH) (28-170-220 GHz), electron cyclotron current drive (ECCD), collective Thomson scattering (CTS), heat-wave propagation experiments, and space-power grid (SPG) applications. Other important applications of gyrotrons are electron cyclotron resonance (ECR) discharges for the generation of multi- charged ions and soft X-rays, as well as industrial materials processing and plasma chemistry. Submillimeter wave gyrotrons are employed in high frequency, broadband electron paramagnetic resonance (EPR) spectroscopy. Additional future applications await the development of novel high power gyro-amplifiers and devices for high resolution radar ranging and imaging in atmospheric and planetary science as well as deep space and specialized satellite communications, RF drivers for next generation high gradient linear accelerators (supercolliders), high resolution Doppler radar, radar ranging and imaging in atmospheric and planetary science, drivers for next-generation high-gradient linear accelerators

Time-dependent spectrum analysis of high power gyrotrons

Energy Technology Data Exchange (ETDEWEB)

Schlaich, Andreas

2015-07-01

stationarity. The systematic experimental characterization of these effects was complemented by thorough investigations using theoretical means and simulations. Here a focus was put on bridging the often too-wide gap between the worlds of simulation and experiment, including the derivation of connections between the quantities involved and rigorous benchmarking. For this, also an extensive and systematic comparison study of multiple major European gyrotron interaction simulation codes was performed and compared with measured values.

Time-dependent spectrum analysis of high power gyrotrons

International Nuclear Information System (INIS)

Schlaich, Andreas

2015-01-01

stationarity. The systematic experimental characterization of these effects was complemented by thorough investigations using theoretical means and simulations. Here a focus was put on bridging the often too-wide gap between the worlds of simulation and experiment, including the derivation of connections between the quantities involved and rigorous benchmarking. For this, also an extensive and systematic comparison study of multiple major European gyrotron interaction simulation codes was performed and compared with measured values.

Quasi-optical gyrotron: present status and future prospect

International Nuclear Information System (INIS)

Tran, M.Q.

1989-01-01

A review of the main experiments on quasi-optical gyrotron is presented. Methods to improve the efficiency (pencil beam electron gun and depressed collector) will be discussed. (author) 5 figs., 1 tab., 10 refs

Research on megawatt gyrotrons, January 1983-December 1984

International Nuclear Information System (INIS)

Read, M.E.

1984-01-01

During the last several years, NRL has performed research on concepts for high power gyrotrons. The work funded by the Department of Energy has been in support of industrial development of high frequency (60 to 140 GHz) CW gyrotrons, with NRL research being on the origination, development, and testing of advanced concepts. The research performed under this agreement has included experimental work on quasi-optical and complex cavity gyrotrons and theoretical efforts on these concepts as well as whispering gallery gyrotrons

New results in development of MW output power gyrotrons for fusion systems

International Nuclear Information System (INIS)

Litvak, A.G.; Denisov, G.G.; Ilin, V.I.; Kurbatov, V.I.; Myasnikov, V.E.; Soluyanova, E.A.; Tai, E.M.; Usachev, S.V.; Zapevalov, V.E.

2005-01-01

The paper presents the latest achievements of the Russian gyrotron team in development of MW power gyrotrons for fusion installations. During two last years four new gyrotrons were designed and tested: a new version of 170 GHz gyrotron for ITER; multi-frequency (105-140 GHz) gyrotron for Asdex-Up, 84GHz gyrotron for LHD and 82.7 GHz gyrotron for SST-1. All these gyrotrons are equipped with diamond CVD windows and depressed collectors

Operation and control of high power Gyrotrons for ECRH systems in SST-1 and Aditya

Energy Technology Data Exchange (ETDEWEB)

Shukla, B.K., E-mail: shukla@ipr.res.in; Bora, D.; Jha, R.; Patel, Jatin; Patel, Harshida; Babu, Rajan; Dhorajiya, Pragnesh; Dalakoti, Shefali; Purohit, Dharmesh

2016-11-15

Highlights: • Operation and control of high power Gyrotrons. • Data acquisition and control (DAQ) for Gyrotron system. • Ignitron based crowbar protection. • VME and PXI based systems. - Abstract: The Electron Cyclotron Resonance Heating (ECRH) system is an important heating system for the reliable start-up of tokamak. The 42 GHz and 82.6 GHz ECRH systems are used in tokamaks SST-1 and Aditya to carry out ECRH related experiments. The Gyrotrons are high power microwave tubes used as a source for ECRH systems. The Gyrotron is a delicate microwave tube, which deliver megawatt level power at very high voltage ∼40–50 kV with the current requirement ∼10 A–50 A. The Gyrotrons are associated with the subsystems like: High voltage power supplies (Beam voltage and anode voltage), dedicated crowbar system, magnet, filament and ion pump power supplies, cooling, interlocks and a dedicated data acquisition & control (DAC) system. There are two levels of interlocks used for the protection of Gyrotron: fast interlocks (arcing, beam over current, dI/dt, anode voltage and anode over current etc.) operate within 10 μs and slow interlocks (cooling, filament, silence of Gyrotron, ion pump and magnet currents) operate within 100 ms. Two Gyrotrons (42 GHz/500 kW/500 ms and 82.6 GHz/200 kW/1000 s) have been commissioned on dummy load for full parameters. The 42 GHz ECRH system has been integrated with SST-1 & Aditya tokamak and various experiments have been carried out related to ECRH assisted breakdown and start-up of tokamak at fundamental and second harmonic. These Gyrotrons are operated with VME based data acquisition and control (DAC) system. The DAC system is capable to acquire 64 digital and 32 analog signals. The system is used to monitor & acquire the data and also used for slow interlocks for the protection of Gyrotron. The data acquired from the system are stored online on VME system and after the shot stored in a file in binary format. The MDSPlus, a set of

Chaos in high-power high-frequency gyrotrons

International Nuclear Information System (INIS)

Airila, M.

2004-01-01

Gyrotron interaction is a complex nonlinear dynamical process, which may turn chaotic in certain circumstances. The emergence of chaos renders dynamical systems unpredictable and causes bandwidth broadening of signals. Such effects would jeopardize the prospect of advanced gyrotrons in fusion. Therefore, it is important to be aware of the possibility of chaos in gyrotrons. There are three different chaos scenarios closely related to the development of high-power gyrotrons: First, the onset of chaos in electron trajectories would lead to difficulties in the design and efficient operation of depressed potential collectors, which are used for efficiency enhancement. Second, the radio-frequency signal could turn chaotic, decreasing the output power and the spectral purity of the output signal. As a result, mode conversion, transmission, and absorption efficiencies would be reduced. Third, spatio-temporal chaos in the resonator field structure can set a limit for the use of large-diameter interaction cavities and high-order TE modes (large azimuthal index) allowing higher generated power. In this thesis, the issues above are addressed with numerical modeling. It is found that chaos in electron residual energies is practically absent in the parameter region corresponding to high efficiency. Accordingly, depressed collectors are a feasible solution also in advanced high-power gyrotrons. A new method is presented for straightforward numerical solution of the one-dimensional self-consistent time-dependent gyrotron equations, and the method is generalized to two dimensions. In 1D, a chart of gyrotron oscillations is calculated. It is shown that the regions of stationary oscillations, automodulation, and chaos have a complicated topology in the plane of generalized gyrotron variables. The threshold current for chaotic oscillations exceeds typical operating currents by a factor of ten. However, reflection of the output signal may significantly lower the threshold. 2D

Towards Overhauser DNP in supercritical CO(2).

Science.gov (United States)

van Meerten, S G J; Tayler, M C D; Kentgens, A P M; van Bentum, P J M

2016-06-01

Overhauser Dynamic Nuclear Polarization (ODNP) is a well known technique to improve NMR sensitivity in the liquid state, where the large polarization of an electron spin is transferred to a nucleus of interest by cross-relaxation. The efficiency of the Overhauser mechanism for dipolar interactions depends critically on fast local translational dynamics at the timescale of the inverse electron Larmor frequency. The maximum polarization enhancement that can be achieved for (1)H at high magnetic fields benefits from a low viscosity solvent. In this paper we investigate the option to use supercritical CO2 as a solvent for Overhauser DNP. We have investigated the diffusion constants and longitudinal nuclear relaxation rates of toluene in high pressure CO2. The change in (1)H T1 by addition of TEMPO radical was analyzed to determine the Overhauser cross-relaxation in such a mixture, and is compared with calculations based on the Force Free Hard Sphere (FFHS) model. By analyzing the relaxation data within this model we find translational correlation times in the range of 2-4ps, depending on temperature, pressure and toluene concentration. Such short correlation times may be instrumental for future Overhauser DNP applications at high magnetic fields, as are commonly used in NMR. Preliminary DNP experiments have been performed at 3.4T on high pressure superheated water and model systems such as toluene in high pressure CO2. Copyright © 2016 Elsevier Inc. All rights reserved.

Depressed collectors for millimeter wave gyrotrons

International Nuclear Information System (INIS)

Singh, A.; Granatstein, V.L.

1992-01-01

The main issues relating to design of depressed collectors for millimeter wave gyrotrons are discussed. A flow diagram is presented and the interlinking steps are outlined. Design studies are given for two kinds of gyrotrons on which severe constraints on the maximum radii of the collectors had been imposed; namely, for a cavity type and a quasi-optical gyrotron. A collector efficiency of the order of 70 percent is shown to be feasible for either case using careful tailoring of magnetic field profiles. A code has been developed to assist in doing this. A general approach toward initial placement of collectors has been indicated

Quasi-optical gyrotron development at the CRPP

International Nuclear Information System (INIS)

Tran, M.Q.

1990-09-01

The operation of the 100GHz quasi-optical (Q.O.) gyrotron of the Centre de Recherches en Physique des Plasmas in Lausanne is described. Power up to 90kW and efficiency up to 12% have been achieved. Other features of the Q.O. gyrotron include single longitudinal mode operation, frequency tunability. Second harmonic emission (200GHz) has been observed with a resonator designed for operation at the fundamental. The issues pertinent to the Q.O. gyrotron concept are also discussed. (author) 26 refs., 13 figs., 2 tabs

Nonstationary oscillations in gyrotrons revisited

International Nuclear Information System (INIS)

Dumbrajs, O.; Kalis, H.

2015-01-01

Development of gyrotrons requires careful understanding of different regimes of gyrotron oscillations. It is known that in the planes of the generalized gyrotron variables: cyclotron resonance mismatch and dimensionless current or cyclotron resonance mismatch and dimensionless interaction length complicated alternating sequences of regions of stationary, periodic, automodulation, and chaotic oscillations exist. In the past, these regions were investigated on the supposition that the transit time of electrons through the interaction space is much shorter than the cavity decay time. This assumption is valid for short and/or high diffraction quality resonators. However, in the case of long and/or low diffraction quality resonators, which are often utilized, this assumption is no longer valid. In such a case, a different mathematical formalism has to be used for studying nonstationary oscillations. One example of such a formalism is described in the present paper

High harmonic terahertz confocal gyrotron with nonuniform electron beam

Energy Technology Data Exchange (ETDEWEB)

Fu, Wenjie; Guan, Xiaotong; Yan, Yang [THz Research Center, School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu 610054 (China)

2016-01-15

The harmonic confocal gyrotron with nonuniform electron beam is proposed in this paper in order to develop compact and high power terahertz radiation source. A 0.56 THz third harmonic confocal gyrotron with a dual arc section nonuniform electron beam has been designed and investigated. The studies show that confocal cavity has extremely low mode density, and has great advantage to operate at high harmonic. Nonuniform electron beam is an approach to improve output power and interaction efficiency of confocal gyrotron. A dual arc beam magnetron injection gun for designed confocal gyrotron has been developed and presented in this paper.

Electron beam instabilities in gyrotron beam tunnels

International Nuclear Information System (INIS)

Pedrozzi, M.; Alberti, S.; Hogge, J.P.; Tran, M.Q.; Tran, T.M.

1997-10-01

Electron beam instabilities occurring in a gyrotron electron beam can induce an energy spread which might significantly deteriorate the gyrotron efficiency. Three types of instabilities are considered to explain the important discrepancy found between the theoretical and experimental efficiency in the case of quasi-optical gyrotrons (QOG): the electron cyclotron maser instability, the Bernstein instability and the Langmuir instability. The low magnetic field gradient in drift tubes of QOG makes that the electron cyclotron maser instability can develop in the drift tube at very low electron beam currents. Experimental measurements show that with a proper choice of absorbing structures in the beam tunnel, this instability can be suppressed. At high beam currents, the electrostatic Bernstein instability can induce a significant energy spread at the entrance of the interaction region. The induced energy spread scales approximately linearly with the electron beam density and for QOG one observes that the beam density is significantly higher than the beam density of an equivalent cylindrical cavity gyrotron. (author) figs., tabs., refs

Development of ITER CODAC compatible gyrotron local control system and its operation

International Nuclear Information System (INIS)

Ohshima, Katsumi; Oda, Yasuhisa; Takahashi, Koji; Terakado, Masayuki; Ikeda, Ryosuke; Moriyama, Shinichi; Kajiwara, Ken; Sakamoto, Keishi; Hayashi, Kazuo

2016-03-01

In Japan Atomic Energy Agency, an ITER relevant control system for ITER gyrotron was developed according to Plant Control Design Handbook. This control system was developed based on ITER CODAC Core System and implemented state machine control of gyrotron operation system, sequential timing control of gyrotron oscillation startup, and data acquisition. The operation of ITER 170 GHz gyrotron was demonstrated with ITER relevant power supply configuration. This system is utilized for gyrotron operation test for ITER procurement. This report describes the architecture of gyrotron local control system, its basic and detailed design, and recent operation results. (author)

100 GHz, 1 MW, CW gyrotron study program. Final report

International Nuclear Information System (INIS)

Felch, K.; Bier, R.; Caplan, M.; Jory, H.

1983-09-01

The results of a study program to investigate the feasibility of various approaches in designing a 100 GHz, 1 MW CW gyrotron are presented. A summary is given of the possible configurations for a high average power, high frequency gyrotron, including an historical survey of experimental results which are relevant to the various approaches. A set of basic scaling considerations which enable qualitative comparisons between particular gyrotron interaction circuits is presented. These calculations are important in understanding the role of various electron beam and circuit parameters in achieving a viable gyrotron design. Following these scaling exercises, a series of design calculations is presented for a possible approach in achieving 100 GHz, 1 MW CW. These calculations include analyses of the electron gun and interaction circuit parts of the gyrotron, and a general analysis of other aspects of a high average power, high frequency gyrotron. Scalability of important aspects of the design to other frequencies is also discussed, as well as key technology issues

110GHz-500kW long-pulse gyrotron with built-in quasi-optical mode converter

International Nuclear Information System (INIS)

Sakamoto, Keishi; Kariya, Tsuyoshi; Hayashi, Ken-ichi.

1994-01-01

We have designed, fabricated, and tested a 110 GHz-500 kW long-pulse gyrotron. The gyrotron incorporates a quasi-optical mode converter which transforms the oscillation mode, TE 22,2 , into a Gaussian radiation beam. The adoption of a built-in mode converter enabled us to design the electron beam collector so as to be capable of tolerating a 2 MW heat load. Attention was also paid to designing the gyrotron cavity and output window so as to permit long-pulse operations. In an experiment, we observed a maximum output power of 550 kW and achieved 1.3 s operation at a power level of 410 kW. (author)

Strategic innovation between PhD and DNP programs: Collaboration, collegiality, and shared resources.

Science.gov (United States)

Edwards, Joellen; Rayman, Kathleen; Diffenderfer, Sandra; Stidham, April

2016-01-01

At least 111 schools and colleges of nursing across the nation provide both PhD and DNP programs (AACN, 2014a). Collaboration between nurses with doctoral preparation as researchers (PhD) and practitioners (DNP) has been recommended as essential to further the profession; that collaboration can begin during the educational process. The purpose of this paper is to describe the development and implementation of successful DNP and PhD program collaboration, and to share the results of that collaboration in an educational setting. Faculty set strategic goals to maximize the effectiveness and efficiency of both new DNP and existing PhD programs. The goals were to promote collaboration and complementarity between the programs through careful capstone and dissertation differentiation, complementary residency activities, joint courses and inter-professional experiences; promote collegiality in a blended on-line learning environment through shared orientation and intensive on-campus sessions; and maximize resources in program delivery through a supportive organizational structure, equal access to technology support, and shared faculty responsibilities as appropriate to terminal degrees. Successes such as student and faculty accomplishments, and challenges such as managing class size and workload, are described. Collaboration, collegiality and the sharing of resources have strengthened and enriched both programs and contributed to the success of students, faculty. These innovative program strategies can provide a solid foundation for DNP and PhD collaboration. Copyright © 2016 Elsevier Inc. All rights reserved.

Cusp-Gun Sixth-Harmonic Slotted Gyrotron

Science.gov (United States)

Stutzman, R. C.; McDermott, D. B.; Hirata Luhmann, Y., Jr.; Gallagher, D. A.; Spencer, T. A.

2000-10-01

A high-harmonic slotted gyrotron has been constructed at UC Davis to be driven by a 70 kV, 3.5 A, axis-encircling electron beam from a Northrop Grumman Cusp gun. The 94 GHz, slotted sixth-harmonic gyrotron is predicted to generate 50 kW with an efficiency of 20%. Using the profile of the adiabatic field reversal from the UC Davis superconducting test-magnet, EGUN simulations predict that an axis-encircling electron beam will be generated with an axial velocity spread of Δ v_z/v_z=10% for the desired velocity ratio of α =v_z/v_z=1.5. The design will also be presented for an 8th-harmonic W-band gyrotron whose magnetic field can be supplied by a lightweight permanent magnet.

Frequency pulling in a low-voltage medium-power gyrotron

Science.gov (United States)

Luo, Li; Du, Chao-Hai; Huang, Ming-Guang; Liu, Pu-Kun

2018-04-01

Many recent biomedical applications use medium-power frequency-tunable terahertz (THz) sources, such as sensitivity-enhanced nuclear magnetic resonance, THz imaging, and biomedical treatment. As a promising candidate, a low-voltage gyrotron can generate watt-level, continuous THz-wave radiation. In particular, the frequency-pulling effect in a gyrotron, namely, the effect of the electron beam parameters on the oscillation frequency, can be used to tune the operating frequency. Most previous investigations used complicated and time-consuming gyrotron nonlinear theory to study the influence of many beam parameters on the interaction performance. While gyrotron linear theory investigation demonstrates the advantages of rapidly and clearly revealing the physical influence of individual key beam parameters on the overall system performance, this paper demonstrates systematically the use of gyrotron linear theory to study the frequency-pulling effect in a low-voltage gyrotron with either a Gaussian or a sinusoidal axial-field profile. Furthermore, simulations of a gyrotron operating in the first axial mode are carried out in the framework of nonlinear theory as a contrast. Close agreement is achieved between the two theories. Besides, some interesting results are obtained. In a low-current sinusoidal-profile cavity, the ranges of frequency variation for different axial modes are isolated from each other, and the frequency tuning bandwidth for each axial mode increases by increasing either the beam voltage or pitch factor. Lowering the voltage, the total tuning ranges are squeezed and become concentrated. However, the isolated frequency regions of each axial mode cannot be linked up unless the beam current is increased, meaning that higher current operation is the key to achieving a wider and continuous tuning frequency range. The results presented in this paper can provide a reference for designing a broadband low-voltage gyrotron.

Analysis of a prototype of a novel 1.5 MW, 170 GHz coaxial cavity gyrotron

International Nuclear Information System (INIS)

Rzesnicki, T.

2007-06-01

A 170 GHz, 2 MW coaxial cavity gyrotron is under development at the Institut fuer Hochleistungsimpuls- und Mikrowellentechnik (IHM) at Forschungszentrum Karlsruhe (FZK) which will be used as a high power microwave source for heating, current drive and stability control of plasmas in the International Thermonuclear Experimental Reactor (ITER). At frequencies above about 100 GHz the output power of conventional gyrotrons with cylindrical hollow waveguide cavities is limited to 1 MW in CW operation mainly due to the high Ohmic losses and the space charge voltage depression of the electron beam. The coaxial geometry enables a reduction of the mode competition in the gyrotron resonator and decreases also the influence of the beam voltage depression. As result a very high order operating mode (for example TE34,19 at 170 GHz) can be chosen which ultimately allows to increase the output power of the gyrotron in CW operation to a value as high as 2 MW. A first prototype of the 170 GHz, 2 MW coaxial cavity gyrotron has been designed, built and experimentally tested in short pulse operation at FZK. The main goal of this work was to investigate experimentally the design of the critical gyrotron components such as electron gun, resonator and a quasi-optical RF system. Those components are same as used in the first industrial coaxial prototype gyrotron for ITER. During the experiments a strong instability was observed inside the gyrotron tube due to the excitation of parasitic low frequency oscillations. The mechanism of the oscillations has been studied and possibilities for their suppression of these oscillations are proposed and experimentally verified. The RF output system is one of the most critical components. It is responsible for the coupling of the gyrotron power out of the gyrotron by converting the microwave power generated in the TE 34,19 -mode into a fundamental free space TEM 0,0 ''Gaussian'' mode. The performance of the RF output system has been tested in low

From Metacognition to Practice Cognition: The DNP e-Portfolio to Promote Integrated Learning.

Science.gov (United States)

Anderson, Kelley M; DesLauriers, Patricia; Horvath, Catherine H; Slota, Margaret; Farley, Jean Nelson

2017-08-01

Educating Doctor of Nursing Practice (DNP) students for an increasingly complex health care environment requires novel applications of learning concepts and technology. A deliberate and thoughtful process is required to integrate concepts of the DNP program into practice paradigm changes to subsequently improve students' abilities to innovate solutions to complex practice problems. The authors constructed or participated in electronic portfolio development inspired by theories of metacognition and integrated learning. The objective was to develop DNP student's reflection, integration of concepts, and technological capabilities to foster the deliberative competencies related to the DNP Essentials and the foundations of the DNP program. The pedagogical process demonstrates how e-portfolios adapted into the doctoral-level curriculum for DNP students can address the Essentials and foster the development of metacognitive capabilities, which translates into practice changes. The authors suggest that this pedagogical approach has the potential to optimize reflective and deliberative competencies among DNP students. [J Nurs Educ. 2017;56(8):497-500.]. Copyright 2017, SLACK Incorporated.

The NNP/DNP shortage: transforming neonatal nurse practitioners into DNPs.

Science.gov (United States)

Pressler, Jana L; Kenner, Carole A

2009-01-01

Neonatal nurse practitioners (NNPs) represent a high-demand specialty practice that is especially targeted for US secondary and tertiary care neonatal intensive care units (NICUs). NNPs make primary decisions about the caregiving of high-risk newborns at the time of admission, throughout hospitalization, at transfer, and at discharge that require an advanced knowledge base in neonatology as well as NICU clinical experience. NNPs prepared at the master's level are currently in very short supply, with some estimates suggesting that for each NNP who graduates, there are 80 positions open across the country. Even with the present shortage, due to the high cost of NNP education, NNP programs are diminishing and those that are remaining are not graduating a sufficient number of new NNPs each year to keep up with the demand. To add to the basic shortage problem, in 2004 the American Association of Colleges of Nursing decided that by 2015, the terminal degree for all nurse practitioners should move from the master's degree to the doctor of nursing practice (DNP) degree. That decision added a minimum of 12 months of full-time education to the advanced education requirements for nurse practitioners. What impact will the decision to require a DNP degree have on NNP specialty practice? Will even more NNP programs close because of faculty shortages of NNPs prepared at the DNP level? If a worse shortage occurs in the number of NNPs prepared to practice in NICUs, will physician assistants or other nonphysician clinicians who meet the need for advanced neonatal care providers replace NNPs? What steps, if any, can nursing take to ensure that NNP specialty practice is still needed and survives after supplementing the DNP requirement to NNP education?

Water accessibility in a membrane-inserting peptide comparing Overhauser DNP and pulse EPR methods

Energy Technology Data Exchange (ETDEWEB)

Segawa, Takuya F., E-mail: takuya.segawa@alumni.ethz.ch; Doppelbauer, Maximilian; Garbuio, Luca; Doll, Andrin; Polyhach, Yevhen O.; Jeschke, Gunnar, E-mail: gjeschke@ethz.ch [Laboratory of Physical Chemistry, ETH Zurich, Vladimir-Prelog-Weg 2, CH-8093 Zurich (Switzerland)

2016-05-21

Water accessibility is a key parameter for the understanding of the structure of biomolecules, especially membrane proteins. Several experimental techniques based on the combination of electron paramagnetic resonance (EPR) spectroscopy with site-directed spin labeling are currently available. Among those, we compare relaxation time measurements and electron spin echo envelope modulation (ESEEM) experiments using pulse EPR with Overhauser dynamic nuclear polarization (DNP) at X-band frequency and a magnetic field of 0.33 T. Overhauser DNP transfers the electron spin polarization to nuclear spins via cross-relaxation. The change in the intensity of the {sup 1}H NMR spectrum of H{sub 2}O at a Larmor frequency of 14 MHz under a continuous-wave microwave irradiation of the nitroxide spin label contains information on the water accessibility of the labeled site. As a model system for a membrane protein, we use the hydrophobic α-helical peptide WALP23 in unilamellar liposomes of DOPC. Water accessibility measurements with all techniques are conducted for eight peptides with different spin label positions and low radical concentrations (10–20 μM). Consistently in all experiments, the water accessibility appears to be very low, even for labels positioned near the end of the helix. The best profile is obtained by Overhauser DNP, which is the only technique that succeeds in discriminating neighboring positions in WALP23. Since the concentration of the spin-labeled peptides varied, we normalized the DNP parameter ϵ, being the relative change of the NMR intensity, by the electron spin concentration, which was determined from a continuous-wave EPR spectrum.

Interpretation of the nonlinear mode excitation in the ITER gyrotron

International Nuclear Information System (INIS)

Nusinovich, G. S.; Sinitsyn, O. V.

2007-01-01

This study was motivated by an interesting physical effect observed in experiments with a 1 MW, 170 GHz, continuous-wave gyrotron developed at the Japan Atomic Energy Agency for plasma heating and current drive in ITER [see, e.g., Fusion Eng. Des. 55, issues 2-3 (2001)]. In these experiments, the gyrotron switching from a parasitic mode to the operating one was observed with the increase in external magnetic field in the region of hard self-excitation of the operating mode where it cannot be excited from the noise level in the absence of other modes. Below, the theory describing this effect is developed. The switching mechanism caused by merging and disappearance of two (one stable and another unstable) equilibrium states with nonzero amplitudes of both modes is proposed. It is found that the present theory can correctly interpret experimental results qualitatively, but the lack of experimental data does not let the authors carry out some simulations more adequate to experimental conditions

Cutaneous drug toxicity from 2,4-dinitrophenol (DNP): Case report and histological description.

Science.gov (United States)

Le, Patricia; Wood, Benjamin; Kumarasinghe, Sujith Prasad

2015-11-01

The use of 2,4-dinitrophenol (DNP) has regained popularity as a weight loss aid in the last two decades due to increased marketing to bodybuilders and the increasing availability of this banned substance via the Internet. 2,4-DNP is a drug of narrow therapeutic index and toxicity results in hyperthermia, diaphoresis, tachycardia, tachypnoea and possible cardiac arrest and death. Skin toxicity from 2,4-DNP has not been reported since the 1930s. We report a case of a 21-year-old bodybuilding enthusiast who presented with a toxic exanthem after taking 2,4-DNP, and describe the first skin biopsy findings in a case of 2,4-DNP toxicity. © 2014 The Australasian College of Dermatologists.

Radioimmunoassay of class-specific antibodies (RIACA): chicken antibodies to DNP

International Nuclear Information System (INIS)

Viljanen, M.K.; Granfors, K.; Toivanen, P.

1977-01-01

A radioimmunological method for the quantitation of class-specific antibodies has been developed. The method allows the quantitation of nanogram per ml concentrations of IgG and IgM-anti-DNP antibodies without any physical or chemical pretreatment of the sample. DNP was coupled covalently to a cyanogen bromide activated paper disk with the augmentation of lysine molecule. Anti-DNP antibodies were allowed to react with the coupled DNP and then quantitated by their capacity to bind 125 I-labelled anti-chicken-μ or anti-chicken-γ. The inter-assay variation coefficients ranged from 8.1 to 14.7% and the mean standard deviations of duplicate determinations were about 11%. The combination of this method with the exact immunoradiometric quantitation of the total serum IgM and IgG, and with an immunoabsorption technique, makes it possible to quantitate class-specific antibodies on weight units

Perspective gyrotron with mode converter for co- and counter-rotation operating modes

Energy Technology Data Exchange (ETDEWEB)

Chirkov, A. V.; Kuftin, A. N. [Institute of Applied Physics, Russian Academy of Sciences, 46 Ul' yanov Street, 603950 Nizhny Novgorod (Russian Federation); Denisov, G. G. [Institute of Applied Physics, Russian Academy of Sciences, 46 Ul' yanov Street, 603950 Nizhny Novgorod (Russian Federation); University of Nizhny Novgorod, 23 Prospekt Gagarina, 603950 Nizhny Novgorod (Russian Federation)

2015-06-29

A gyrotron oscillator operating efficiently at modes of both rotations was developed and tested. The gyrotron operation can be switched between two modes: co- and counter rotating ones with respect to electron rotation in a resonance magnetic field. A synthesized mode converter provides output of both waves in the form of two different paraxial wave beams corresponding to direction of the mode rotation. Measured gyrotron power (up to 2 MW), interaction efficiency (34%), and diffraction losses in the mode converter (≈2%) agree well with the design values. The proposed gyrotron scheme alloys principal enhancement in the device parameters—possibility of electronic switching of output wave beam direction and possibility to arrange an effective scheme to provide frequency/phase locking of a gyrotron-oscillator.

Perspective gyrotron with mode converter for co- and counter-rotation operating modes

International Nuclear Information System (INIS)

Chirkov, A. V.; Kuftin, A. N.; Denisov, G. G.

2015-01-01

A gyrotron oscillator operating efficiently at modes of both rotations was developed and tested. The gyrotron operation can be switched between two modes: co- and counter rotating ones with respect to electron rotation in a resonance magnetic field. A synthesized mode converter provides output of both waves in the form of two different paraxial wave beams corresponding to direction of the mode rotation. Measured gyrotron power (up to 2 MW), interaction efficiency (34%), and diffraction losses in the mode converter (≈2%) agree well with the design values. The proposed gyrotron scheme alloys principal enhancement in the device parameters—possibility of electronic switching of output wave beam direction and possibility to arrange an effective scheme to provide frequency/phase locking of a gyrotron-oscillator

The 140 GHZ, 1 MW Gyrotron - Status and Recent Results

Science.gov (United States)

Gantenbein, G.; Dammertz, G.; Illy, S.; Kern, S.; Leonhardt, W.; Piosczyk, B.; Schmid, M.; Thumm, M.; Braune, H.; Erckmann, V.; Laqua, H. P.; Michel, G.; Kasparek, W.; Lechte, C.; Legrand, F.; Lievin, C.; Prinz, O.

2009-04-01

A 10 MW ECRH system is currently under construction for the stellarator W7-X which will be built up and operated by IPP in Greifswald, Germany. The present status of the complete system is reported in [1]. The RF power will be provided by 10 gyrotrons. A European collaboration has been established to develop and build the 10 gyrotrons each with an output power of 1 MW for continuous wave (CW) operation [2]. Nine gyrotrons are being manufactured by Thales Electron Devices (TED), Vélizy, France, one gyrotron was produced by CPI, Palo Alto, CA and passed the acceptance tests at IPP. The acceptance tests of the TED gyrotrons are performed at the test stand at FZK and on site at IPP. The first series tube yielded a total output power of 0.98 MW, with an efficiency of 31 % (without a single stage depressed collector) in short pulse operation and of 0.92 MW in pulses of 1800 s (efficiency of almost 45 % at a depression voltage of 29 kV) [3], The Gaussian mode output power was 0.91 MW. The RF power, measured in a calorimetric load at the end of a 25 m long quasi-optical transmission line with seven mirrors, was 0.87 MW. In this contribution typical results of the next series gyrotrons will be reported.

Stability and nonlinear dynamics of gyrotrons at cyclotron harmonics

International Nuclear Information System (INIS)

Saraph, G.P.; Nusinovich, G.S.; Antonsen, T.M. Jr.; Levush, B.

1992-01-01

Gyrotrons operating at higher harmonics of the cyclotron frequency can overcome the frequency limitations caused by achievable strength of the magnetic field. However, the excitation of modes at the fundamental frequency exhibit a major problem for stable operation of harmonic gyrotron at high power with high efficiency. Therefore the issues of stability of gyrotron operation at the cyclotron harmonics and nonlinear dynamics of mode interaction are of great importance. The results of the authors stability analysis and multimode simulation are presented here. A detailed nonlinear theory of steady state single mode operation at cyclotron harmonics has been presented previously, taking into account beam-wave coupling and nonlinear gain function at cyclotron harmonics. A set of equations describing low gain regime interaction of modes resonant at different cyclotron harmonics was studied before. The multifrequency time-dependent nonlinear analysis presented here is based on previous gyrotron studies and beam-wave interaction at cyclotron harmonics. The authors have determined the parameter space for stable single mode operation at the second harmonic. The nonlinear dynamics of mode evolution and mode interaction for a harmonic gyrotron is presented. A new nonlinear effect in which the parasite at the fundamental harmonic helps excite the operating mode at the second harmonic has been demonstrated

Development of new generation software tools for simulation of electron beam formation in novel high power gyrotrons

Science.gov (United States)

Sabchevski, S.; Zhelyazkov, I.; Benova, E.; Atanassov, V.; Dankov, P.; Thumm, M.; Dammertz, G.; Piosczyk, B.; Illy, S.; Tran, M. Q.; Alberti, S.; Hogge, J.-Ph

2006-07-01

Computer aided design (CAD) based on numerical experiments performed by using adequate physical models and efficient simulation codes is an indispensable tool for development, investigation, and optimization of gyrotrons used as radiation sources for electron cyclotron resonance heating (ECRH) of fusion plasmas. In this paper, we review briefly the state-of-the-art in the field of modelling and simulation of intense, relativistic, helical electron beams formed in the electron-optical systems (EOS) of powerful gyrotrons. We discuss both the limitations of the known computer codes and the requirements for increasing their capabilities for solution of various design problems that are being envisaged in the development of the next generation gyrotrons for ECRH. Moreover, we present the concept followed by us in an attempt to unite the advantages of the modern programming techniques with self-consistent, first-principles 3D physical models in the creation of a new highly efficient and versatile software package for simulation of powerful gyrotrons.

Improved Collectors for High Power Gyrotrons

International Nuclear Information System (INIS)

Ives, R. Lawrence; Singh, Amarjit; Read, Michael; Borchard, Philipp; Neilson, Jeff

2009-01-01

High power gyrotrons are used for electron cyclotron heating, current drive and parasitic mode suppression in tokamaks for fusion energy research. These devices are crucial for successful operation of many research programs around the world, including the ITER program currently being constructed in France. Recent gyrotron failures resulted from cyclic fatigue of the copper material used to fabricated the collectors. The techniques used to collect the spent beam power is common in many gyrotrons produced around the world. There is serious concern that these tubes may also be at risk from cyclic fatigue. This program addresses the cause of the collector failure. The Phase I program successfully demonstrated feasibility of a mode of operation that eliminates the cyclic operation that caused the failure. It also demonstrated that new material can provide increased lifetime under cyclic operation that could increase the lifetime by more than on order of magnitude. The Phase II program will complete that research and develop a collector that eliminates the fatigue failures. Such a design would find application around the world.

Multimegawatt relativistic harmonic gyrotron traveling-wave tube amplifier experiments

International Nuclear Information System (INIS)

Menninger, W.L.; Danly, B.G.; Temkin, R.J.

1996-01-01

The first multimegawatt harmonic relativistic gyrotron traveling-wave tube (gyro-twt) amplifier experiment has been designed, built, and tested. Results from this experimental setup, including the first ever reported third-harmonic gyro-twt results, are presented. Operation frequency is 17.1 GHz. Detailed phase measurements are also presented. The electron beam source is SNOMAD-II, a solid-state nonlinear magnetic accelerator driver with nominal parameters of 400 kV and 350 A. The flat-top pulsewidth is 30 ns. The electron beam is focused using a Pierce geometry and then imparted with transverse momentum using a bifilar helical wiggler magnet. Experimental operation involving both a second-harmonic interaction with the TE 21 mode and a third-harmonic interaction with the TE 31 mode, both at 17 GHz, has been characterized. The third-harmonic interaction resulted in 4-MW output power and 50-dB single-pass gain, with an efficiency of up to ∼8%. The best measured phase stability of the TE 31 amplified pulse was ±10 degree over a 9-ns period. The phase stability was limited because the maximum RF power was attained when operating far from wiggler resonance. The second harmonic, TE 21 had a peak amplified power of 2 MW corresponding to 40-dB single-pass gain and 4% efficiency. The second-harmonic interaction showed stronger superradiant emission than the third-harmonic interaction. Characterizations of the second- and third-harmonic gyro-twt experiments presented here include measurement of far-field radiation patterns, gain and phase versus interaction length, phase stability, and output power versus input power

Study of the parasitic oscillations in a gyrotron; Etudes des oscillations parasites dans un gyrotron

Energy Technology Data Exchange (ETDEWEB)

Pedrozzi, M. [Ecole Polytechnique Federale, Lausanne (Switzerland). Centre de Recherche en Physique des Plasma (CRPP)

1997-01-01

This work is dedicated to the study of parasitic instabilities in a gyrotron, and to the influence of such instabilities on the interaction efficiency. The gyrotron is a high-power millimeter wave radiation source, based on the resonant interaction between a weakly relativistic electron beam immersed in a guiding magnetic field, and an electromagnetic wave. The gyrotron investigated here operates at a frequency close to 100 GHz: its main feature is that it is quasi optical. In this configuration, the electron beam interacts with a high order TEM eigenmode of a Fabry-Perot resonator, the axis of which is perpendicular to the electron beam path. During the development of this source, the highest efficiency that was achieved is approximately 30% lower than the theoretical predictions. At the same time, parasitic oscillations at frequencies close to the maximum relativistic cyclotronic frequency are detected. The power associated with these oscillations ranges from a few watts to a few kilowatts, with threshold currents of the order of 100 mA. It is suspected that the excitation of parasitic oscillations in the beam duct section before the interaction region might have a dramatic effect on the electron beam distribution function inducing, in particular, an energy spread. The cyclotron maser instability responsible for the energy exchange between particles and fields in a gyrotron, is very sensitive to energy spreads. It is thus necessary to identify the origin of the parasitic radiation. A few physical mechanisms suspected to lead to a degradation of the electron beam properties were investigated: the cyclotron maser process itself, the Bernstein electrostatic instability and the Langmuir instability. The experimental work concentrated on the study of the beam ducts between the electron gun and the resonant cavity. (author) figs., tabs., 90 refs.

1H DNP at 1.4 T of Water Doped with a Triarylmethyl-Based Radical

DEFF Research Database (Denmark)

Wind, Robert A.; Ardenkjær-Larsen, Jan Henrik

1999-01-01

Recently a triarylmethyl-based (TAM) radical has been developed for research in biological and other aqueous systems, and in low magnetic fields, 10 mT or less, large 1H dynamic nuclear polarization (DNP) enhancements have been reported. In this paper the DNP properties of this radical have been...... perpendicular to the electric component of the microwave field. It was found that with this probe the temperature increase in the sample after 4 s of microwave irradiation with an incident power of 10 W was only 16°C. For the investigations, 10 mM of the TAM radical was dissolved in deionized, but not degassed...... than the largest high-resolution magnet available to date. It is concluded that DNP MRM in this field, which corresponds to a standard microwave frequency of 9 GHz, has the potential to significantly increase the sensitivity in NMR and MRI experiments of small aqueous samples doped with the TAM radical....

Review of gyrotron development at the Centre de Recherche en Physique des Plasmas

International Nuclear Information System (INIS)

Tran, M.Q.

1990-01-01

Gyrotron development activities at the Centre de Recherche en Physique des Plasmas in Lausanne are directed along two directions, quasi optical gyrotrons and, with less emphasis, cylindrical cavity gyrotrons. This paper will review the recent work performed in these two fields. (author) 9 refs., 5 figs

Application of Fusion Gyrotrons to Enhanced Geothermal Systems (EGS)

Science.gov (United States)

Woskov, P.; Einstein, H.; Oglesby, K.

2013-10-01

The potential size of geothermal energy resources is second only to fusion energy. Advances are needed in drilling technology and heat reservoir formation to realize this potential. Millimeter-wave (MMW) gyrotrons and related technologies developed for fusion energy research could contribute to enabling EGS. Directed MMW energy can be used to advance rock penetration capabilities, borehole casing, and fracking. MMWs are ideally suited because they can penetrate through small particulate extraction plumes, can be efficiently guided long distances in borehole dimensions, and continuous megawatt sources are commercially available. Laboratory experiments with a 10 kW, 28 GHz CPI gyrotron have shown that granite rock can be fractured and melted with power intensities of about 1 kW/cm2 and minute exposure times. Observed melted rock MMW emissivity and estimated thermodynamics suggest that penetrating hot, hard crystalline rock formations may be economic with fusion research developed MMW sources. Supported by USDOE, Office of Energy Efficiency and Renewable Energy and Impact Technologies, LLC.

Electron gun simulation for 95 GHz gyrotron

Energy Technology Data Exchange (ETDEWEB)

Singh, Udaybir; Kumar, Nitin; Sinha, A.K., E-mail: uday.ceeri@gmail.com, E-mail: aksinha@ceeri.ernet.in [Gyrotron Laboratory, Microwave Tube Area, Central Electronics Engineering Research Institute, Pilani (India); Purohit, L.P. [Department of Physics, Gurukul Kangri Vishwavidyalaya, Haridwar (India)

2011-07-01

A triode type Magnetron Injection Gun (MIG) for a 2 MW, 95 GHz Gyrotron has been designed by using commercially available code EGUN and another in-house developed code MIGANS. The operating mode of the gyrotron is TE{sub 24.8} and it is operated in the fundamental harmonic. The operating voltages of the modulating anode and the accelerating anode are 61 kV and 85 kV respectively. The parametric dependences of modulating anode voltage and cathode magnetic field on the beam quality have also been studied. (author)

Electron gun simulation for 95 GHz gyrotron

International Nuclear Information System (INIS)

Singh, Udaybir; Kumar, Nitin; Sinha, A.K.; Purohit, L.P.

2011-01-01

A triode type Magnetron Injection Gun (MIG) for a 2 MW, 95 GHz Gyrotron has been designed by using commercially available code EGUN and another in-house developed code MIGANS. The operating mode of the gyrotron is TE 24.8 and it is operated in the fundamental harmonic. The operating voltages of the modulating anode and the accelerating anode are 61 kV and 85 kV respectively. The parametric dependences of modulating anode voltage and cathode magnetic field on the beam quality have also been studied. (author)

Recent operating experience with Varian 70 GHz and 140 GHz gyrotrons

International Nuclear Information System (INIS)

Felch, K.; Bier, R.; Fox, L.; Huey, H.; Ives, L.; Jory, H.; Lopez, N.; Shively, J.; Spang, S.

1985-01-01

The design features and initial test results of Varian 70 GHz and 140 GHz CW gyrotrons are presented. The first experimental 140 GHz tube has achieved an output power of 102 kW at 24% efficiency under pulsed conditions in the desired TE 031 0 cavity mode. Further tests aimed at achieving the design goal of 100 kW CW are currently underway. The 70 GHz tube has achieved an output power of 200 kW under pulsed conditions and possesses a wide dynamic range for output power variations. 6 refs., 8 figs

Asymmetric modes in gyrotron tubes and their experimental study

International Nuclear Information System (INIS)

Garin, P.; Jedar, E.; Jendrzejczak, G.; mourier, G.; Payen, F.; Teyssier, L.

1989-01-01

High power gyrotron tubes suffer from the competition between oscillations on different modes of the resonant cavity. Different techniques for mode selection are outlined and the advantages of non symmetric modes are indicated. Their experimental study is described on a 100 GHz-200 kW - 100 ms - TE34 gyrotron. Some possible extrapolations are briefly presented. (author). 6 refs.; 4 figs

Accurate frequency measurements on gyrotrons using a ''gyro-radiometer''

International Nuclear Information System (INIS)

Rebuffi, L.

1986-08-01

Using an heterodyne system, called ''Gyro-radiometer'', accurated frequency measurements have been carried out on VARIAN 60 GHz gyrotrons. Changing the principal tuning parameters of a gyrotron, we have detected frequency variations up to 100 MHz, ∼ 40 MHz frequency jumps and smaller jumps (∼ 10 MHz) when mismatches in the transmission line were present. FWHM bandwidth of 300 KHz, parasitic frequencies and frequency drift during 100 msec pulses have also been observed. An efficient method to find a stable-, high power-, long pulse-working point of a gyrotron loaded by a transmission line, has been derived. In general, for any power value it is possible to find stable working conditions tuning the principal parameters of the tube in correspondance of a maximum of the emitted frequency

Development of MW gyrotrons for fusion devices by University of Tsukuba

International Nuclear Information System (INIS)

Minami, R.; Kariya, T.; Imai, T.; Numakura, T.; Endo, Y.; Nakabayashi, H.; Eguchi, T.; Shimozuma, T.; Kubo, S.; Yoshimura, Y.; Igami, H.; Takahashi, H.; Mutoh, T.; Ito, S.; Idei, H.; Zushi, H.; Yamaguchi, Y.; Sakamoto, Keishi; Mitsunaka, Y.

2012-11-01

Over-1 MW power gyrotrons for electron cyclotron heating (ECH) have been developed in the joint program of NIFS and University of Tsukuba. The obtained maximum outputs are 1.9 MW for 0.1 s on the 77 GHz Large Helical Device (LHD) tube and 1.0 MW for 1 ms on the 28 GHz GAMMA 10 one, which are new records in these frequency ranges. In long pulse operation, 300 kW for 40 min at 77 GHz and 540 kW for 2 s at 28 GHz were achieved. A new program of 154 GHz 1 MW development has started for high density plasma heating in LHD and the first tube has been fabricated. These lower frequency tubes like 77 GHz or 28 GHz one are also important for advanced magnetic fusion devices, which use Electron Bernstein Wave (EBW) heating / current drive. As a next activity of 28 GHz gyrotron, we have already started the development of over-1.5 MW gyrotron and a new design study of 28 GHz / 35 GHz dual frequency gyrotron, which indicates the practicability of the multi-purpose gyrotron. (author)

Fast power measurement on a 30 GHz/15 kW gyrotron

International Nuclear Information System (INIS)

Saala, G.

2004-09-01

This work has been developed in the scope of a study-thesis at the Universitaet Karlsruhe (TH). The realization took place at the Institut fuer Hochleistungsimpuls- und Mikrowellentechnik (IHM) at the Forschungszentrum Karlsruhe (FZK). The aim was to investigate the possibilities of a fast power measurement at a compact, industrial gyrotron-system. To measure the output-power a small fraction of the gyrotron microwave radiation is coupled out and analyzed using a diode-detector. At the beginning of the work a mirror of the quasi-optical transmission line with a built in λ/4-coupler was available. This built-in coupler and other coupling structures which have been set up during this work have been characterized. To be able to perform reproduceable measurements several computer programs have been developed. Using these programs the gyrotron-system can be remote-controlled from a PC. The diode-detector signal has been analyzed under different conditions of gyrotron operation with respect to its short-term- and long-term-stability. After that the dependency of the calorimetrically measured output-power of the gyrotron has been used to calibrate the diode-voltage. (orig.)

Diamond window and its application to ITER gyrotron

International Nuclear Information System (INIS)

Sakamoto, K.

1999-01-01

On the background of having to reduce the overall cost for ITER to 50% it is proposed to replace conventional glass windows on gyrotrons by diamonds. The successful production and testing of such diamond windows is reported. A diamond window can transmit 5 times more power than usual double disk transmission windows while only costing 3 times as much. As a tradeoff, the gyrotrons could be replaced by more powerful ones and one would need fewer of them

Quasi-optical internal mode converters for 110 GHz gyrotrons

International Nuclear Information System (INIS)

Harper, B.M.; Lorbeck, J.A.; Vernon, R.J.

1995-01-01

Many early gyrotrons had a microwave output in the same mode that was produced in the microwave cavity, e.g. the TE 02 mode. These modes were often converted outside of the tube to a more desirable mode for plasma heating using a system of perturbed-wall waveguide mode converters. The current generation of gyrotrons commonly have cavity modes with a high azimuthal index, such as the rotating TE 22,6 mode. Mode conversion by means of waveguide mode converters is not usually practical for such cases. However, an output of a Gaussian beam or other desirable field pattern can be obtained by using a Vlasov-type launcher feeding a series of two or more reflectors. This system may be placed outside or inside of the gyrotron but there are advantages to placing it within the tube, e.g. allowing for a larger collector and smaller reflectors. When such a converter system is placed inside the gyrotron, it is usually preferable to use a modification to the simple Vlasov launcher such as the Denisov-type launcher, which incorporates a series of perturbations within it. The authors have designed both internal and external versions of such quasi-optical converters. They discuss an internal converter which was designed for use inside of a Varian 110 GHz gyrotron producing the TE 22,6 cavity mode. This design consists of four reflectors which are fed by a Denisov-type launcher. Design techniques for the reflector system are discussed and experimental results are presented

Startup and mode competition in a 420 GHz gyrotron

Science.gov (United States)

Qixiang Zhao, A.; Sheng Yu, B.; Tianzhong Zhang, C.

2017-09-01

In the experiments of a 420 GHz second-harmonic gyrotron, it is found that the electron beam voltage and current ranges for single mode operation of TE17.4 are slightly narrower than those in the simulation. To explain this phenomenon, the startup scenario has been investigated with special emphasis on mode competition. The calculations indicate that the decreases of the operating ranges are caused by the voltage overshoot in the startup scenario.

Modeling of mode purity in high power gyrotrons

International Nuclear Information System (INIS)

Cai, S.Y.; Antonsen, T.M. Jr.; Saraph, G.P.

1993-01-01

Spurious mode generation at the same frequency of the operational mode in a high power gyrotron can significantly reduce the power handling capability and the stability of a gyrotron oscillator because these modes are usually not matched at the output window and thus have high absorption and reflection rates. To study the generation of this kind of mode, the authors developed a numerical model based on an existing multimode self-consistent time-dependent computer code. This model includes both TE and TM modes and accounts for mode transformations due to the waveguide inhomogeneity. With this new tool, they study the mode transformation in the gyrotron and the possibility of excitation of parasitic TE and TM modes in the up taper section due to the gyroklystron mechanism. Their preliminary results show moderate excitation of both TE and TM modes at the same frequency as the main operating mode at locations near their cutoff. Details of the model and further simulation results will be presented

Simultaneous Stabilization of Gyrotron Frequency and Power by PID Double Feedback Control on the Acceleration and Anode Voltages

Science.gov (United States)

Khutoryan, E. M.; Idehara, T.; Kuleshov, A. N.; Tatematsu, Y.; Yamaguchi, Y.; Matsuki, Y.; Fujiwara, T.

2017-07-01

In this paper, we present the results of simultaneous stabilization of both the frequency and the output power by a double PID feedback control on the acceleration and anode voltages in the 460-GHz gyrotron FU CW GVI, also known as "Gyrotron FU CW GO-1" (according to the nomenclature adopted at Osaka University). The approach used in the experiments is based on the modulation of the cyclotron frequency and the pitch factor (velocity ratio) of the electron beam by varying the acceleration and the anode voltages, respectively. In a long-term experiment, the frequency and power stabilities were made to be better than ±10-6 and ±1%, respectively.

Evaluating resilience of DNP3-controlled SCADA systems against event buffer flooding

Energy Technology Data Exchange (ETDEWEB)

Yan, Guanhua [Los Alamos National Laboratory; Nicol, David M [UNIV OF IL; Jin, Dong [UNIV OF IL

2010-12-16

The DNP3 protocol is widely used in SCADA systems (particularly electrical power) as a means of communicating observed sensor state information back to a control center. Typical architectures using DNP3 have a two level hierarchy, where a specialized data aggregator device receives observed state from devices within a local region, and the control center collects the aggregated state from the data aggregator. The DNP3 communication between control center and data aggregator is asynchronous with the DNP3 communication between data aggregator and relays; this leads to the possibility of completely filling a data aggregator's buffer of pending events, when a relay is compromised or spoofed and sends overly many (false) events to the data aggregator. This paper investigates how a real-world SCADA device responds to event buffer flooding. A Discrete-Time Markov Chain (DTMC) model is developed for understanding this. The DTMC model is validated by a Moebius simulation model and data collected on real SCADA testbed.

Megawatt Power Level 120 GHz Gyrotrons for ITER Start-Up

Energy Technology Data Exchange (ETDEWEB)

Choi, E M; Marchewka, C; Mastovsky, I; Shapiro, M A; Sirigiri, J R; Temkin, R J [MIT - Plasma Science and Fusion Center, NW16-186, 167 Albany Street, Cambridge, MA 02139 (United States)

2005-01-01

We report operation of a 110 GHz gyrotron with 1.67 MW of output power measured in short pulses (3{mu}s) at an efficiency of 42% in the TE{sub 22,6} mode. We also present a preliminary design of a 1 MW, 120 GHz gyrotron for ITER start-up with an efficiency greater than 50%.

Megawatt Power Level 120 GHz Gyrotrons for ITER Start-Up

International Nuclear Information System (INIS)

Choi, E M; Marchewka, C; Mastovsky, I; Shapiro, M A; Sirigiri, J R; Temkin, R J

2005-01-01

We report operation of a 110 GHz gyrotron with 1.67 MW of output power measured in short pulses (3μs) at an efficiency of 42% in the TE 22,6 mode. We also present a preliminary design of a 1 MW, 120 GHz gyrotron for ITER start-up with an efficiency greater than 50%

Building skills in organizational and systems changes: a DNP-FNP clinical curriculum.

Science.gov (United States)

Hoyle, Christine; Johnson, Gail

2015-04-13

DNP-prepared nurse practitioner leaders play a pivotal role in organizational change and quality improvement consistent with the IHI Triple Aim: improving quality of care, health of populations, and reducing cost. A DNP-FNP curriculum is described, designed to build students' leadership competencies for systems change in healthcare settings.

Experimental considerations concerning the velocity measurement of the relativistic electron beam in a gyrotron by means of Thomson scattering

International Nuclear Information System (INIS)

Siegrist, M.R.; Soumagne, G.; Tran, M.Q.

1992-11-01

The feasibility of Thomson scattering to determine the beam velocity in a gyrotron has been analyzed and preliminary experiments to implement such a system on our 100 GHz quasi-optical gyrotron are reported. Although the project had to be abandoned due to technical problems, the conclusions are that for the 90 o scattering arrangement discussed it should be possible to determine at least one velocity component with an acceptable signal-to-noise ratio. (author) 11 figs., 10 refs

Research on a 170 GHz, 2 MW coaxial cavity gyrotron with inner-outer corrugation

Energy Technology Data Exchange (ETDEWEB)

Hou, Shenyong, E-mail: houshenyong@sohu.com [Yangtze Normal University, Chongqing, 408001 (China); Yu, Sheng; Li, Hongfu [University of Electronics Science and Technology of China, Chengdu 610054 (China)

2015-03-15

In this paper, a coaxial cavity gyrotron with inner-outer corrugation is researched. The electron kineto-equations and the first order transmission line equations of the gyrotron are derived from Lorentz force equation and the transmission line theory, respectively. And then, a 2 MW, 170 GHz coaxial cavity gyrotron with inner-outer corrugation is designed. By means of numerical calculation, the beam-wave interaction of the coaxial cavity gyrotron with inner-outer corrugation is investigated. Results show that the efficient and the outpower of the gyrotron are 42.3% and 2.38 MW, respectively.

Efficient DNP NMR of Membrane Proteins: Sample Preparation Protocols, Sensitivity, and Radical Location

Science.gov (United States)

Liao, Shu Y.; Lee, Myungwoon; Wang, Tuo; Sergeyev, Ivan V.; Hong, Mei

2016-01-01

Although dynamic nuclear polarization (DNP) has dramatically enhanced solid-state NMR spectral sensitivities of many synthetic materials and some biological macromolecules, recent studies of membrane-protein DNP using exogenously doped paramagnetic radicals as polarizing agents have reported varied and sometimes surprisingly limited enhancement factors. This motivated us to carry out a systematic evaluation of sample preparation protocols for optimizing the sensitivity of DNP NMR spectra of membrane-bound peptides and proteins at cryogenic temperatures of ~110 K. We show that mixing the radical with the membrane by direct titration instead of centrifugation gives a significant boost to DNP enhancement. We quantify the relative sensitivity enhancement between AMUPol and TOTAPOL, two commonly used radicals, and between deuterated and protonated lipid membranes. AMUPol shows ~4 fold higher sensitivity enhancement than TOTAPOL, while deuterated lipid membrane does not give net higher sensitivity for the membrane peptides than protonated membrane. Overall, a ~100 fold enhancement between the microwave-on and microwave-off spectra can be achieved on lipid-rich membranes containing conformationally disordered peptides, and absolute sensitivity gains of 105–160 can be obtained between low-temperature DNP spectra and high-temperature non-DNP spectra. We also measured the paramagnetic relaxation enhancement of lipid signals by TOTAPOL and AMUPol, to determine the depths of these two radicals in the lipid bilayer. Our data indicate a bimodal distribution of both radicals, a surface-bound fraction and a membrane-bound fraction where the nitroxides lie at ~10 Å from the membrane surface. TOTAPOL appears to have a higher membrane-embedded fraction than AMUPol. These results should be useful for membrane-protein solid-state NMR studies under DNP conditions and provide insights into how biradicals interact with phospholipid membranes. PMID:26873390

Efficient DNP NMR of membrane proteins: sample preparation protocols, sensitivity, and radical location

Energy Technology Data Exchange (ETDEWEB)

Liao, Shu Y.; Lee, Myungwoon; Wang, Tuo [Massachusetts Institute of Technology, Department of Chemistry (United States); Sergeyev, Ivan V. [Bruker Biospin (United States); Hong, Mei, E-mail: meihong@mit.edu [Massachusetts Institute of Technology, Department of Chemistry (United States)

2016-03-15

Although dynamic nuclear polarization (DNP) has dramatically enhanced solid-state NMR spectral sensitivities of many synthetic materials and some biological macromolecules, recent studies of membrane-protein DNP using exogenously doped paramagnetic radicals as polarizing agents have reported varied and sometimes surprisingly limited enhancement factors. This motivated us to carry out a systematic evaluation of sample preparation protocols for optimizing the sensitivity of DNP NMR spectra of membrane-bound peptides and proteins at cryogenic temperatures of ~110 K. We show that mixing the radical with the membrane by direct titration instead of centrifugation gives a significant boost to DNP enhancement. We quantify the relative sensitivity enhancement between AMUPol and TOTAPOL, two commonly used radicals, and between deuterated and protonated lipid membranes. AMUPol shows ~fourfold higher sensitivity enhancement than TOTAPOL, while deuterated lipid membrane does not give net higher sensitivity for the membrane peptides than protonated membrane. Overall, a ~100 fold enhancement between the microwave-on and microwave-off spectra can be achieved on lipid-rich membranes containing conformationally disordered peptides, and absolute sensitivity gains of 105–160 can be obtained between low-temperature DNP spectra and high-temperature non-DNP spectra. We also measured the paramagnetic relaxation enhancement of lipid signals by TOTAPOL and AMUPol, to determine the depths of these two radicals in the lipid bilayer. Our data indicate a bimodal distribution of both radicals, a surface-bound fraction and a membrane-bound fraction where the nitroxides lie at ~10 Å from the membrane surface. TOTAPOL appears to have a higher membrane-embedded fraction than AMUPol. These results should be useful for membrane-protein solid-state NMR studies under DNP conditions and provide insights into how biradicals interact with phospholipid membranes.

Electron beam emission and interaction of double-beam gyrotron

International Nuclear Information System (INIS)

Singh, Udaybir; Kumar, Anil; Kumar, Nitin; Kumar, Narendra; Pratap, Bhanu; Purohit, L.P.; Sinha, A.K.

2012-01-01

Highlights: ► The complete electrical design of electron gun and interaction structure of double-beam gyrotron. ► EGUN code is used for the simulation of electron gun of double-beam gyrotron. ► MAGIC code is used for the simulation of interaction structure of double-beam gyrotron. ► Design validations with other codes. - Abstract: This paper presents the numerical simulation of a double-beam magnetron injection gun (DB-MIG) and beam-wave interaction for 60 GHz, 500 kW gyrotron. The beam-wave interaction calculations, power and frequency growth estimation are performed by using PIC code MAGIC. The maximum output power of 510 kW at 41.5% efficiency, beam currents of 6 A and 12 A, electron beam velocity ratios of 1.41 and 1.25 and beam voltage of 69 kV are estimated. To obtain the design parameters, the DB-MIG with maximum transverse velocity spread less than 5% is designed. The computer simulations are performed by using the commercially available code EGUN and the in-house developed code MIGANS. The simulated results of DB-MIG design obtained by using the EGUN code are also validated with another trajectory code TRAK, which are in good agreement.

Electron beam emission and interaction of double-beam gyrotron

Energy Technology Data Exchange (ETDEWEB)

Singh, Udaybir, E-mail: uday.ceeri@gmail.com [Gyrotron Laboratory, Microwave Tube Area, Central Electronics Engineering Research Institute (CEERI), Council of Scientific and Industrial Research (CSIR), Pilani, Rajasthan 333031 (India); Department of Physics, Gurukul Kangri University, Haridwar 249404 (India); Kumar, Anil [Gyrotron Laboratory, Microwave Tube Area, Central Electronics Engineering Research Institute (CEERI), Council of Scientific and Industrial Research (CSIR), Pilani, Rajasthan 333031 (India); Kumar, Nitin, E-mail: nitin_physika@rediffmail.com [Gyrotron Laboratory, Microwave Tube Area, Central Electronics Engineering Research Institute (CEERI), Council of Scientific and Industrial Research (CSIR), Pilani, Rajasthan 333031 (India); Kumar, Narendra; Pratap, Bhanu [Gyrotron Laboratory, Microwave Tube Area, Central Electronics Engineering Research Institute (CEERI), Council of Scientific and Industrial Research (CSIR), Pilani, Rajasthan 333031 (India); Purohit, L.P. [Department of Physics, Gurukul Kangri University, Haridwar 249404 (India); Sinha, A.K., E-mail: aksinha@ceeri.ernet.in [Gyrotron Laboratory, Microwave Tube Area, Central Electronics Engineering Research Institute (CEERI), Council of Scientific and Industrial Research (CSIR), Pilani, Rajasthan 333031 (India)

2012-09-15

Highlights: Black-Right-Pointing-Pointer The complete electrical design of electron gun and interaction structure of double-beam gyrotron. Black-Right-Pointing-Pointer EGUN code is used for the simulation of electron gun of double-beam gyrotron. Black-Right-Pointing-Pointer MAGIC code is used for the simulation of interaction structure of double-beam gyrotron. Black-Right-Pointing-Pointer Design validations with other codes. - Abstract: This paper presents the numerical simulation of a double-beam magnetron injection gun (DB-MIG) and beam-wave interaction for 60 GHz, 500 kW gyrotron. The beam-wave interaction calculations, power and frequency growth estimation are performed by using PIC code MAGIC. The maximum output power of 510 kW at 41.5% efficiency, beam currents of 6 A and 12 A, electron beam velocity ratios of 1.41 and 1.25 and beam voltage of 69 kV are estimated. To obtain the design parameters, the DB-MIG with maximum transverse velocity spread less than 5% is designed. The computer simulations are performed by using the commercially available code EGUN and the in-house developed code MIGANS. The simulated results of DB-MIG design obtained by using the EGUN code are also validated with another trajectory code TRAK, which are in good agreement.

Plasma scattering measurement using a submillimeter wave gyrotron as a radiation source

International Nuclear Information System (INIS)

Ogawa, I.; Idehara, T.; Itakura, Y.; Myodo, M.; Hori, T.; Hatae, T.

2004-01-01

Plasma scattering measurement is an effective technique to observe low frequency density fluctuations excited in plasma. The spatial and wave number resolutions and the S/N ratio of measurement depend on the wavelength range, the size and the intensity of a probe beam. A well-collimated, submillimeter wave beam is suitable for improving the spatial and wave number resolutions. Application of high frequency gyrotron is effective in improving the S/N ratio of the measurement because of its capacity to deliver high power. Unlike the molecular vapor lasers, the gyrotrons generate diverging beam of radiation with TE mn mode structure. It is therefore necessary to convert the output radiation into a Gaussian beam. A quasi-optical antenna is a suitable element for the conversion system under consideration since it is applicable to several TE 0n and TE 1n modes. In order to apply the gyrotron to plasma scattering measurement, we have stabilized the output (P = 110 W, f = 354 GHz) of gyrotron up to the level (ΔP/P < 1 %, Δf< 10 kHz). The gyrotron output can be stabilized by decreasing the fluctuation of the cathode potential. (authors)

Experimental results and recent developments on the EU 2 MW 170 GHz coaxial cavity gyrotron for ITER

Directory of Open Access Journals (Sweden)

Thumm M. K.

2012-09-01

Full Text Available The European Gyrotron Consortium (EGYC is responsible for developing one set of 170 GHz mm-wave sources, in support of Europe’s contribution to ITER. The original plan of targeting a 2 MW coaxial gyrotron is currently under discussion, in view of essential delays and damages. This paper reports on the latest results and plans with regard to the two 2 MW gyrotron prototypes, the industrial prototype at CRPP’s CW test stand and a modular pre-prototype at KIT. The industrial prototype was delivered to CRPP end of September 2011 and reached an output power of 2 MW at an efficiency of 45 % and with good RF beam pattern, in only four days of short pulse RF test. These results validated all design changes made in reaction to the results of the experiments in 2008. On the fifth experimental day, an internal absorber broke, terminating any further experiment with this tube. In parallel, design and experimental activities at KIT went on, in particular featuring reduced stray radiation down to 4% of the RF power. Next years’ plans for the 2 MW modular pre-prototype foresee a stepwise increase of pulse length.

Photonic-band-gap gyrotron amplifier with picosecond pulses

Science.gov (United States)

Nanni, Emilio A.; Jawla, Sudheer; Lewis, Samantha M.; Shapiro, Michael A.; Temkin, Richard J.

2017-12-01

We report the amplification of 250 GHz pulses as short as 260 ps without observation of pulse broadening using a photonic-band-gap circuit gyrotron traveling-wave-amplifier. The gyrotron amplifier operates with a device gain of 38 dB and an instantaneous bandwidth of 8 GHz. The operational bandwidth of the amplifier can be tuned over 16 GHz by adjusting the operating voltage of the electron beam and the magnetic field. The amplifier uses a 30 cm long photonic-band-gap interaction circuit to confine the desired TE03-like operating mode while suppressing lower order modes which can result in undesired oscillations. The circuit gain is >55 dB for a beam voltage of 23 kV and a current of 700 mA. These results demonstrate the wide bandwidths and a high gain achievable with gyrotron amplifiers. The amplification of picosecond pulses of variable lengths, 260-800 ps, shows good agreement with the theory using the coupled dispersion relation and the gain-spectrum of the amplifier as measured with quasi-CW input pulses.

Continuous-Wave Operation of a Frequency-Tunable 460-GHz Second-Harmonic Gyrotron for Enhanced Nuclear Magnetic Resonance

Science.gov (United States)

Torrezan, Antonio C.; Han, Seong-Tae; Mastovsky, Ivan; Shapiro, Michael A.; Sirigiri, Jagadishwar R.; Temkin, Richard J.; Griffin, Robert G.; Barnes, Alexander B.

2012-01-01

The design, operation, and characterization of a continuous-wave (CW) tunable second-harmonic 460-GHz gyrotron are reported. The gyrotron is intended to be used as a submillimeter-wave source for 700-MHz nuclear magnetic resonance experiments with sensitivity enhanced by dynamic nuclear polarization. The gyrotron operates in the whispering-gallery mode TE11,2 and has generated 16 W of output power with a 13-kV 100-mA electron beam. The start oscillation current measured over a range of magnetic field values is in good agreement with theoretical start currents obtained from linear theory for successive high-order axial modes TE11,2,q. The minimum start current is 27 mA. Power and frequency tuning measurements as a function of the electron cyclotron frequency have also been carried out. A smooth frequency tuning range of 1 GHz was obtained for the operating second-harmonic mode either by magnetic field tuning or beam voltage tuning. Long-term CW operation was evaluated during an uninterrupted period of 48 h, where the gyrotron output power and frequency were kept stable to within ±0.7% and ±6 ppm, respectively, by a computerized control system. Proper operation of an internal quasi-optical mode converter implemented to transform the operating whispering-gallery mode to a Gaussian-like beam was also verified. Based on the images of the gyrotron output beam taken with a pyroelectric camera, the Gaussian-like mode content of the output beam was computed to be 92% with an ellipticity of 12%. PMID:23761938

The MTX computer control system for the 400 kilowatt 140 GHz gyrotron

International Nuclear Information System (INIS)

Jackson, M.C.; Ferguson, S.W.; Petersen, D.E.

1991-09-01

A 400 kilowatt, 140 Ghz gyrotron is employed on MTX as a source of direct plasma heating and, additionally, as a driver for a free electron laser, which is used for plasma heating. The control system that operates this gyrotron uses a new graphics oriented software system called TACL (Thaumaturgic Automated Control Logic) developed by the Continuous Electron Beam Accelerator Facility (CEBAF) and owned by DOE. This control language does not require a software specialist, but is easily handled by the engineer or technician working on the system. All control logic and custom displays are entered via graphics oriented editors and no actual lines of code need to be written. The graphics displays make the gyrotron operation quite simple and allow individual users to define displays to meet their own needs or develop one for a specific set of tests to be run. The system, additionally, can be used for logging functions, which have been found quite useful in tracking long term trends in vacion current and calorimetry of gyrotron cooling circuits. The system is composed of one computer (HP 9000 series 300) controlling multiple CAMAC crates located at the various components used in the system. A second series 300 computer is used as a supervisor and is located in the main tokamak control room. This supervisory computer provides remote operation of the gyrotron, and also provides a link to the microwave transport vacuum control (also TACL). The supervisory computer, additionally, is used as a subsystem status summary point for permissives to the gyrotron control system

Development of steady-state 2 MW, 170 GHz gyrotrons for ITER

International Nuclear Information System (INIS)

Piosczyk, B.; Arnold, A.; Thumm, M.; Dammertz, G.; Heidinger, R.; Illy, S.; Jin, J.; Koppenburg, K.; Leonhardt, W.; Neffe, G.; Rzesnicki, T.; Schmid, M.; Yang, X.; Alberti, S.; Chavan, R.; Fasel, D.; Goodman, T.; Henderson, M.; Hogge, J.P.; Tran, M.Q.; Yovchev, I.; Erckmann, V.; Laqua, H.P.; Michel, G.; Gantenbein, G.; Kasparek, W.; Mueller, G.; Schwoerer, K.; Bariou, D.; Beunas, A.; Giguet, E.; LeCloarec, G.; Legrand, F.; Lievin, C.; Dumbrajs, O.

2005-01-01

A prototype of a 1 MW, CW, 140 GHz conventional gyrotron for the W7-X stellarator in Greifswald/Germany has been tested successfully and the fabrication of series tubes started. In extended studies the feasibility for manufacturing a continuously operated high power coaxial cavity gyrotron has been demonstrated and all needed data for an industrial design has been obtained. Based on this results the fabrication of a first prototype of a 2 MW, CW, 170 GHz coaxial cavity gyrotron started recently in cooperation between European research institutions and European tube industry. The prototype tube is foreseen to be tested in 2006 at CRPP Lausanne where a suitable test facility is under construction. (author)

Performance, diagnostics, controls and plans for the gyrotron system on the DIII-D tokamak

Directory of Open Access Journals (Sweden)

Ponce D.M.

2012-09-01

Full Text Available The DIII-D ECH complex is being upgraded with three new depressed collector gyrotrons. The performance of the existing system has been very good. As more gyrotrons having higher power are added to the system, diagnostics of gyrotron operation, optimization of the performance and qualification of components for higher power become more important. A new FPGA-based gyrotron control system is being installed, additional capabilities for rapid real time variation of the rf injection angles by the DIII-D Plasma Control System are being tested and infrastructure enhancements are being completed. Longer term plans continue to include ECH as a major component in the DIII-D heating and current drive capabilities.

Integrated Design of Undepressed Collector for Low Power Gyrotron

Science.gov (United States)

Kumar, Anil; Goswami, Uttam K.; Poonia, Sunita; Singh, Udaybir; Kumar, Nitin; Alaria, M. K.; Bera, A.; Khatun, Hasina; Sinha, A. K.

2011-06-01

A 42 GHz, 200 kW continuous wave (CW) gyrotron, operating at TE03 mode is under development for the electron cyclotron resonance plasma heating of the Indian TOKAMAK system. The gyrotron is made up of an undepressed collector. The undepressed collector is simple to design and cost effective. In this paper, a detailed design study of the undepressed collector for the 42 GHz gyrotron is presented. The EGUN code is used to analyze the spent electron beam trajectory for the maximum spread to reduce the power loading on the collector surface. To achieve wall loading ≤1 kW/cm2, a collector with a length of 800 mm and a radius of 42.5 mm is designed. The design also includes the three magnet systems around the collector for maximum and uniform beam spread. The thermal and the structural analyses are done using the ANSYS code to optimize the collector structure and dimensions with tolerance.

Communication Test for ‘MatrikonOPC Server for SCADA DNP 3’ with RTDS

DEFF Research Database (Denmark)

Wu, Qiuwei; Cha, Seung-Tae; Saleem, Arshad

2010-01-01

The purpose of the communication test for ‘MatrikonOPC server for SCADA DNP 3’ with RTDS is to verify the data exchange between the ‘MatrikonOPC server for SCADA DNP 3’ and the RTDS using the DNP 3 protocol.The communication test is part of the work for the ‘Wind in Øresund’ project. The objective...... of the ‘Wind in Øresund’ project is to build a demonstration and education system of power system operation and control with a RTDS and a SCADA system....

Local control unit for ITER-India gyrotron test facility (IIGTF)

Energy Technology Data Exchange (ETDEWEB)

Rathod, Vipal, E-mail: vipal.rathod@iter-india.org; Shah, Ronak; Mandge, Deepak; Parmar, Rajvi; Rao, S.L.

2016-11-15

Highlights: • A dedicated full scale ITER prototype Local Control Unit for ITER-India Gyrotron test facility. • National Instruments® make PXIe system for real time control & data acquisition and Siemens® PLC for sequence control function. • Hardwired FPGA based fast protection interlock system. • High speed analog fiber optical transmission link using V/F and F/V technique. • Software framework based on LabVIEW™ platform and ITER CODAC Core System. - Abstract: Electron Cyclotron system on ITER, is one of the important RF ancillary systems based on high power Gyrotron RF sources, that is used for plasma heating and current drive applications. To operate a Gyrotron source, various auxiliary systems and services such as Super Conducting Magnet set, High Voltage Power Supplies, Auxiliary Power Supplies, Waveguide components, Cooling water system and a Local Control Unit (LCU) are required. The LCU plays a very crucial role for the safe and reliable operation of Gyrotron system. A dedicated full scale ITER prototype LCU is being developed for testing and commissioning of an ITER like Test Gyrotron at ITER-India Gyrotron Test facility (IIGTF). The main functions of LCU include Sequence Control, Local Interlock Protection and Real Time Data Acquisition. PLC based slow controller is used for implementing the Sequence Control & Slow Interlock functions. Critical Protection Interlocks are required to have a response time of <10 μs and are implemented using custom built hardware and PXIe based fast controller. Also PXIe system is used for implementing Real Time Data Acquisition function that is required to have slow and fast acquisition with online visualization and off line analysis facility. A Signal Conditioning Unit (SCU) is used to interface and faithfully transmit the field signals to the remote control systems. Necessary controller hardware is procured and several pre-prototype developments have been taken up to establish the critical subsystems such as

Local control unit for ITER-India gyrotron test facility (IIGTF)

International Nuclear Information System (INIS)

Rathod, Vipal; Shah, Ronak; Mandge, Deepak; Parmar, Rajvi; Rao, S.L.

2016-01-01

Highlights: • A dedicated full scale ITER prototype Local Control Unit for ITER-India Gyrotron test facility. • National Instruments® make PXIe system for real time control & data acquisition and Siemens® PLC for sequence control function. • Hardwired FPGA based fast protection interlock system. • High speed analog fiber optical transmission link using V/F and F/V technique. • Software framework based on LabVIEW™ platform and ITER CODAC Core System. - Abstract: Electron Cyclotron system on ITER, is one of the important RF ancillary systems based on high power Gyrotron RF sources, that is used for plasma heating and current drive applications. To operate a Gyrotron source, various auxiliary systems and services such as Super Conducting Magnet set, High Voltage Power Supplies, Auxiliary Power Supplies, Waveguide components, Cooling water system and a Local Control Unit (LCU) are required. The LCU plays a very crucial role for the safe and reliable operation of Gyrotron system. A dedicated full scale ITER prototype LCU is being developed for testing and commissioning of an ITER like Test Gyrotron at ITER-India Gyrotron Test facility (IIGTF). The main functions of LCU include Sequence Control, Local Interlock Protection and Real Time Data Acquisition. PLC based slow controller is used for implementing the Sequence Control & Slow Interlock functions. Critical Protection Interlocks are required to have a response time of <10 μs and are implemented using custom built hardware and PXIe based fast controller. Also PXIe system is used for implementing Real Time Data Acquisition function that is required to have slow and fast acquisition with online visualization and off line analysis facility. A Signal Conditioning Unit (SCU) is used to interface and faithfully transmit the field signals to the remote control systems. Necessary controller hardware is procured and several pre-prototype developments have been taken up to establish the critical subsystems such as

High-power and long-pulse operation of TE{sub 31,11} mode gyrotron

Energy Technology Data Exchange (ETDEWEB)

Ikeda, Ryosuke, E-mail: ikeda.ryosuke@jaea.go.jp; Kajiwara, Ken; Oda, Yasuhisa; Takahashi, Koji; Sakamoto, Keishi

2015-10-15

Highlights: • We are under development of TE{sub 31,11} mode gyrotron to aim ITER specification. • HE{sub 11} mode purity reached 96% of ITER specification. • Mode competition was suppressed in initial phase of oscillation by anode voltage control. • Maximum output power of 1.2 MW was achieved. • Steady state operation of 500 MJ was achieved. - Abstract: The ITER electron cyclotron system is designed to inject a 20 MW RF beam by using twenty-four 170 GHz/1 MW gyrotrons. JAEA is currently developing a gyrotron having a high-order mode (TE{sub 31,11}) to reduce the heat load in the cavity resonator and achieve an output power greater than 1 MW. The measured radiation profile at the front of the diamond window agreed with the results of the calculation. In order to suppress RF loss in the equatorial and upper port launchers, a high-quality HE{sub 11} mode is required at the exit of the matching optics unit (MOU). An HE{sub 11} mode purity of 96% was achieved by finely adjusting the two mirrors in the MOU. During the oscillation start-up phase, mode competition with counter-rotating TE{sub 29,12} mode was observed on the higher magnetic field side which caused arcing and pressure increase in the gyrotron. To avoid the counter-rotating TE{sub 29,12} mode from being excited, a start-up scenario that controls the voltage between the anode and cathode electrodes at the initial phase of operation was introduced, which was able to achieve a stable start-up of TE{sub 31,11} mode. A 1.2 MW output power having a total electric efficiency of 43% was obtained in high-power experiments. In steady-state operation, a 1000 s oscillation length and output power of 0.51 MW was achieved.

Efficient Low-Voltage Operation of a CW Gyrotron Oscillator at 233 GHz.

Science.gov (United States)

Hornstein, Melissa K; Bajaj, Vikram S; Griffin, Robert G; Temkin, Richard J

2007-02-01

The gyrotron oscillator is a source of high average power millimeter-wave through terahertz radiation. In this paper, we report low beam power and high-efficiency operation of a tunable gyrotron oscillator at 233 GHz. The low-voltage operating mode provides a path to further miniaturization of the gyrotron through reduction in the size of the electron gun, power supply, collector, and cooling system, which will benefit industrial and scientific applications requiring portability. Detailed studies of low-voltage operation in the TE(2) (,) (3) (,) (1) mode reveal that the mode can be excited with less than 7 W of beam power at 3.5 kV. During CW operation with 3.5-kV beam voltage and 50-mA beam current, the gyrotron generates 12 W of RF power at 233.2 GHz. The EGUN electron optics code describes the low-voltage operation of the electron gun. Using gun-operating parameters derived from EGUN simulations, we show that a linear theory adequately predicts the low experimental starting currents.

The MTX computer control system for the 400 kilowatt 140 Ghz gyrotron

International Nuclear Information System (INIS)

Jackson, M.C.; Ferguson, S.W.; Petersen, D.E.

1992-01-01

This paper reports on a 400 kilowatt, 140 Ghz gyrotron employed on MTX as a source of direct plasma heating and, additionally, as a driver for a free electron laser, which is used for plasma heating. The control system that operates this gyrotron uses a new graphics oriented software system called TACL (Thaumaturgic Automated Control Logic) developed by the Continuous Electron Beam Accelerator Facility (CEBAF) and owned by DOE. This control language does not require a software specialist, but is easily handled by the engineer or technician working on the system. All control logic and custom displays are entered via graphics oriented editors and no actual lines of code need to be written. The graphics displays make the gyrotron operation quite simple and allow individual users to define displays to meet their own needs or develop one for a specific set of tests to be run. The system, additionally, can be used for data logging functions, which have been found quite useful in tracking long term trends in vacion current and calorimetry of gyrotron cooling circuits

A quasi-optical and corrugated waveguide microwave transmission system for simultaneous dynamic nuclear polarization NMR on two separate 14.1 T spectrometers

Science.gov (United States)

Dubroca, Thierry; Smith, Adam N.; Pike, Kevin J.; Froud, Stuart; Wylde, Richard; Trociewitz, Bianca; McKay, Johannes; Mentink-Vigier, Frederic; van Tol, Johan; Wi, Sungsool; Brey, William; Long, Joanna R.; Frydman, Lucio; Hill, Stephen

2018-04-01

Nuclear magnetic resonance (NMR) is an intrinsically insensitive technique, with Boltzmann distributions of nuclear spin states on the order of parts per million in conventional magnetic fields. To overcome this limitation, dynamic nuclear polarization (DNP) can be used to gain up to three orders of magnitude in signal enhancement, which can decrease experimental time by up to six orders of magnitude. In DNP experiments, nuclear spin polarization is enhanced by transferring the relatively larger electron polarization to NMR active nuclei via microwave irradiation. Here, we describe the design and performance of a quasi-optical system enabling the use of a single 395 GHz gyrotron microwave source to simultaneously perform DNP experiments on two different 14.1 T (1H 600 MHz) NMR spectrometers: one configured for magic angle spinning (MAS) solid state NMR; the other configured for solution state NMR experiments. In particular, we describe how the high power microwave beam is split, transmitted, and manipulated between the two spectrometers. A 13C enhancement of 128 is achieved via the cross effect for alanine, using the nitroxide biradical AMUPol, under MAS-DNP conditions at 110 K, while a 31P enhancement of 160 is achieved via the Overhauser effect for triphenylphosphine using the monoradical BDPA under solution NMR conditions at room temperature. The latter result is the first demonstration of Overhauser DNP in the solution state at a field of 14.1 T (1H 600 MHz). Moreover these results have been produced with large sample volumes (∼100 μL, i.e. 3 mm diameter NMR tubes).

Characterization and optimization of the visualization performance of continuous flow overhauser DNP hyperpolarized water MRI: Inversion recovery approach.

Science.gov (United States)

Terekhov, Maxim; Krummenacker, Jan; Denysenkov, Vasyl; Gerz, Kathrin; Prisner, Thomas; Schreiber, Laura Maria

2016-03-01

Overhauser dynamic nuclear polarization (DNP) allows the production of liquid hyperpolarized substrate inside the MRI magnet bore as well as its administration in continuous flow mode to acquire MR images with enhanced signal-to-noise ratio. We implemented inversion recovery preparation in order to improve contrast-to-noise ratio and to quantify the overall imaging performance of Overhauser DNP-enhanced MRI. The negative enhancement created by DNP in combination with inversion recovery (IR) preparation allows canceling selectively the signal originated from Boltzmann magnetization and visualizing only hyperpolarized fluid. The theoretical model describing gain of MR image intensity produced by steady-state continuous flow DNP hyperpolarized magnetization was established and proved experimentally. A precise quantification of signal originated purely from DNP hyperpolarization was achieved. A temperature effect on longitudinal relaxation had to be taken into account to fit experimental results with numerical prediction. Using properly adjusted IR preparation, the complete zeroing of thermal background magnetization was achieved, providing an essential increase of contrast-to-noise ratio of DNP-hyperpolarized water images. To quantify and optimize the steady-state conditions for MRI with continuous flow DNP, an approach similar to that incorporating transient-state thermal magnetization equilibrium in spoiled fast field echo imaging sequences can be used. © 2015 Wiley Periodicals, Inc.

Soviet Development of Gyrotrons

Science.gov (United States)

1986-05-01

Relationship Type of Device Remarks V, - Vc, anomalous Doppler Capable of 100 percent efficiency, CRM but more cumbersome than Cheren- kov devices V...authors; and discusses inlividual Soviet reseaLc- groups, the basic organizational units responAiLle for the CRM and gyrotron research and development. The...maintained a cCnEistEnt iecord of significant achievements; it has managed to overcome the systenic yeaxness of the Soviet R&C systeg in teimg atle to

Gyrotron: an application of the relativistic bunching of electrons to the generation of intense millimeter microwave radiation

International Nuclear Information System (INIS)

Caplan, M.

1986-01-01

The cyclotron maser or gyrotron is capable of generating high power microwaves at millimeter wave frequencies for applications in fusion heating, radar astronomy and communications. Analytic and numerical simulation models are developed that describe the behavior of these devices under realistic laboratory conditions including the effects of circuit geometry, beam thermal spread, and mode competition. In Chapter 2, a generalized linear theory for the gyrotron is presented in the form of an integro-differential equation that can be solved within various circuit geometries thus describing gyro-amplifiers, gyro-oscillatory and gyroklystrons. In Chapter 3 a complete description of a finite size electromagnetic particle simulation model is presented that describes gyrotrons operating in a TE/sub mn/ waveguide mode. In Chapter 4 simulations and theoretical analysis are made of gyrotron amplifiers operating in the TE/sub 01/ mode. In Chapter 5 the linear eigenmodes and eigenfrequencies of gyrotron oscillators are examined. In Chapter 6 the experimental development of a GHz gyrotron is presented. Theoretical and numerical predictions of oscillation thresholds and efficiencies compare favorably with experimental data

Design of an electronically tunable millimeter wave Gyrotron Backward Wave Oscillator

International Nuclear Information System (INIS)

Caplan, M.

1987-01-01

A non-linear self-consistent computer simulation code is used to analyze the saturated output of the Gyrotron Backward Wave Oscillator (Gyro BWO) which can be used as a tunable driver for a 250 GHz FEL amplifier. Simulations show that the Gyrotron BWO using a Pierce/Wiggler gun configuration can produce at least 10 kW of microwave power over the range 249 GHz to 265 GHz by varying beam voltage alone

Analytic theory of the gyrotron

International Nuclear Information System (INIS)

Lentini, P.J.

1989-06-01

An analytic theory is derived for a gyrotron operating in the linear gain regime. The gyrotron is a coherent source of microwave and millimeter wave radiation based on an electron beam emitting at cyclotron resonance Ω in a strong, uniform magnetic field. Relativistic equations of motion and first order perturbation theory are used. Results are obtained in both laboratory and normalized variables. An expression for cavity threshold gain is derived in the linear regime. An analytic expression for the electron phase angle in momentum space shows that the effect of the RF field is to form bunches that are equal to the unperturbed transit phase plus a correction term which varies as the sine of the input phase angle. The expression for the phase angle is plotted and bunching effects in and out of phase (0 and -π) with respect to the RF field are evident for detunings leading to gain and absorption, respectively. For exact resonance, field frequency ω = Ω, a bunch also forms at a phase of -π/2. This beam yields the same energy exchange with the RF field as an unbunched, (nonrelativistic) beam. 6 refs., 10 figs

Status of the development of the EU 170 GHz/1 MW/CW gyrotron

Energy Technology Data Exchange (ETDEWEB)

Pagonakis, Ioannis Gr., E-mail: ioannis.pagonakis@kit.edu [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); Albajar, Ferran [The European Joint Undertaking for ITER and The Development of Fusion Energy, Barcelona (Spain); Alberti, Stefano [École Polytechnique Fédérale de Lausanne, Centre de Recherches en Physique des Plasmas (CRPP), Lausanne (Switzerland); Avramidis, Konstantinos [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); Bonicelli, Tullio [The European Joint Undertaking for ITER and The Development of Fusion Energy, Barcelona (Spain); Braunmueller, Falk [École Polytechnique Fédérale de Lausanne, Centre de Recherches en Physique des Plasmas (CRPP), Lausanne (Switzerland); Bruschi, Alex [Plasma Physics Institute, National Research Council of Italy, Milano (Italy); Chelis, Ioannis [School of Electrical and Computer Engineering, National Technical University of Athens (Greece); Cismondi, Fabio [The European Joint Undertaking for ITER and The Development of Fusion Energy, Barcelona (Spain); Gantenbein, Gerd [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); Hermann, Virgile [Thales Electron Devices (TED), Vélizy-Villacoublay (France); Hesch, Klaus [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); Hogge, Jean-Philippe [École Polytechnique Fédérale de Lausanne, Centre de Recherches en Physique des Plasmas (CRPP), Lausanne (Switzerland); Jelonnek, John; Jin, Jianbo; Illy, Stefan [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); Ioannidis, Zisis C. [Faculty of Physics, National and Kapodistrian University of Athens (Greece); Kobarg, Thorsten [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany); and others

2015-10-15

The progress in the development of the European 170 GHz, 1 MW/CW gyrotron for electron cyclotron heating & current drive (ECH&CD) on ITER is reported. A continuous wave (CW) prototype is being manufactured by Thales Electron Devices (TED), France, while a short-pulse (SP) prototype gyrotron is in parallel under manufacture at Karlsruhe Institute of Technology (KIT), with the purpose of validating the design of the CW industrial prototype components. The fabrication of most of the sub-assemblies of the SP prototype has been completed. In a first step, an existing magnetron injection gun (MIG) available at KIT was used. Despite this non-ideal configuration, the experiments provided a validation of the design, substantiated by an excellent agreement with numerical simulations. The tube, operated without a depressed collector, is able to produce more than 1 MW of output power with efficiency in excess of 30%, as expected, and compatible with the ITER requirements.

Development of collective Thomson scattering system using the gyrotrons of sub-tera Hz region

International Nuclear Information System (INIS)

Tatematsu, Y.; Kubo, S.; Nishiura, M.

2010-11-01

Collective Thomson scattering (CTS) system is being developed for fusion plasma and CTS measurement on the large helical device (LHD) plasma is discussed. Sub-terahertz frequencies are suitable to the probe beam for CTS on LHD. According to the feasibility study, frequency around 0.4 THz is best for the CTS measurement on LHD high density plasma, and power of 100 kW is required. Thus, only gyrotrons in the sub-terahertz range can meet these parameters. At the first stage of development, second harmonic gyrotrons have been developed. A sealed-off type of gyrotrons has been manufactured to improve a demountable one. Measured output power has increased to about 60 kW. In parallel with the development of gyrotrons, an actual CTS system using a 77 GHz gyrotron originally installed for heating is being developed as a benchmark of LHD CTS. A heterodyne receiver system of a fundamental mixer with a fixed frequency local oscillator was installed on the upstream of the transmission line. The probe beam is 100% power modulated at 50 Hz to separate the scattering component from background ECE. Signals that can be attributed to the CTS were obtained and the analysis method of these data is developed. (author)

Development of over 1 MW and multi-frequency gyrotrons for fusion

International Nuclear Information System (INIS)

Imai, T.; Kariya, T.; Minami, R.; Numakura, T.; Kato, T.; Endo, Y.; Ichimura, M.; Eguchi, T.; Mitsunaka, Y.; Shimozuma, T.; Kubo, S.; Takahashi, H.; Yoshimura, Y.; Igami, H.; Ito, S.; Mutoh, T.; Sakamoto, Keishi; Idei, H.; Zushi, H.; Nagasaki, K.; Sano, F.; Ono, M.

2014-10-01

The development of wide frequency range from 14 to 300 GHz of high power mega-watt gyrotron for fusion is in progress in University of Tsukuba. The strong development activity was carried out in collaboration with JAEA, NIFS, TETD and universities. Over-1 MW dual frequency gyrotron of new frequency range (14 – 35 GHz), where the reduction of diffraction loss and cathode optimization are quite important, has been developed for EC/EBW H and CD for GAMMA 10/PDX, QUEST, Heliotron J and NSTX-U. Output power of 1.25 MW at 28 GHz and estimated oscillation power of 1.2 MW at 35.45 GHz from the same tube have been achieved with the cathode angle improvement and two frequency window. This is the first demonstration of the over 1 MW dual-frequency operations in lower frequency, which contributes to the technology of wide band multi-frequency/multi-MW tube. The output power of 600 kW for 2 s at 28 GHz is also demonstrated. It is applied to the QUEST and has resulted higher EC-driven current than ever. As for higher frequency range, in the joint program of NIFS and Tsukuba for LHD ECH gyrotrons, a new frequency of 154 GHz has been successfully developed with a TE 28,8 cavity, which delivered 1.16 MW for 1 s and the total power of 4.4 MW to LHD plasma with other three 77 GHz tubes, which extended the LHD plasma to high T e region. All these gyrotron performances are new records in each frequency range. The sub-THz gyrotron development is also just begun in collaboration with JAEA for Demo-Reactor ECH system. (author)

Control of the Superconducting Magnets current Power Supplies of the TJ-II Gyrotrons

International Nuclear Information System (INIS)

Ros, A.; Fernandez, A.; Tolkachev, A.; Catalan, G.

2006-01-01

The TJ-II ECRH heating system consists of two gyrotrons, which can deliver a maximum power of 300 kW at a frequency of 53.2 GHz. Another 28 GHz gyrotron is going to be used in the Bernstein waves heating system. In order to get the required frequency, the gyrotrons need and homogeneous magnetic field of several tesla, which is generated by a superconducting coil field by a current source. This document describes the current source control as well as the high precision ammeters control. These ammeters measure the current in the superconducting coils. The user interface and the programming of the control system are described. The communication between devices is also explained. (author) 9 Refs

A study of parametric instability in a harmonic gyrotron: Designs of third harmonic gyrotrons at 94 GHz and 210 GHz

International Nuclear Information System (INIS)

Saraph, G.P.; Antonsen, T.M. Jr.; Nusinovich, G.S.; Levush, B.

1995-01-01

Mode competition can present a major hurdle in achieving stable, efficient operation of a gyrotron at the cyclotron harmonics. A type of mode interaction in which three modes at different cyclotron harmonics are parametrically coupled together is analyzed here. This coupling can lead to parametric excitation or suppression of a mode; cyclic mode hopping; or the coexistence of three modes. Simulation results are presented for the parametric instability involving modes at the fundamental, second harmonic, and third harmonic of the cyclotron frequency. It is shown that the parametric excitation can lead to stable, efficient operation of a high-power gyrotron at the third harmonic. Based on this phenomenon, two practical designs are presented here for the third harmonic operation at 94 and 210 GHz. copyright 1995 American Institute of Physics

An Academic-Practice Partnership to Advance DNP Education and Practice.

Science.gov (United States)

Howard, Patricia B; Williams, Tracy E

During the past decade, the growth of doctor of nursing practice (DNP) programs in the United States has been phenomenal, with most focusing on the preparation of advanced practice registered nurses. Simultaneously, academic-practice partnerships have been a frequent subject of discussion for nursing's leading academic, administrative, and practice organizations. Numerous reports about academic-practice partnerships concerning aspects of baccalaureate nursing education exist, but partnership accounts for DNP programs are essentially nonexistent. The purpose of this article is to describe the initial phase of an academic-practice partnership between a multisystem health care organization and a college of nursing in a public land-grant university in the southeastern United States. The 7-year partnership agreement between Norton Healthcare and the University of Kentucky College of Nursing was designed to prepare 5 cohorts of 20 to 30 baccalaureate-prepared staff nurses as DNP graduates for advanced practice registered nurse eligibility. The description of partnering institution characteristics frames an emphasis on elements of the partnership proposal, contractual agreement, and partner responsibilities along with the logic model evaluation plan. Lessons learned include the importance of proposals and contracts to sustain the partnership, frequent communication to build trust, and strategic analysis for rapid response to challenging situations. Copyright © 2016 Elsevier Inc. All rights reserved.

Numerical Simulation of MIG for 42 GHz, 200 kW Gyrotron

Science.gov (United States)

Singh, Udaybir; Bera, Anirban; Kumar, Narendra; Purohit, L. P.; Sinha, Ashok K.

2010-06-01

A triode type magnetron injection gun (MIG) of a 42 GHz, 200 kW gyrotron for an Indian TOKAMAK system is designed by using the commercially available code EGUN. The operating voltages of the modulating anode and the accelerating anode are 29 kV and 65 kV respectively. The operating mode of the gyrotron is TE03 and it is operated in fundamental harmonic. The simulated results of MIG obtained with the EGUN code are validated with another trajectory code TRAK.

Startup methods for single-mode gyrotron operation

International Nuclear Information System (INIS)

Whaley, D.R.; Tran, M.Q.; Alberti, S.; Tran, T.M.; Antonsen, T.M. Jr.; Dubrovin, A.; Tran, C.

1995-01-01

Experimental results of startup studies on a 118 GHz TE 22,6 gyrotron are presented and compared with theory. The startup paths through the energy-velocity-pitch-angle plane are determined by the time evolution of the beam parameters during the startup phase. These startup paths are modified by changing the anode and cathode voltage rise from zero to their nominal values and are seen to determine the cavity oscillating mode. Experimental results show specifically that competition between the TE 22,6 and TE -19,7 mode can be completely eliminated by use of the proper startup method in a case where a typical triode startup results in oscillation in the competing TE -19,7 mode. These new results are shown to be in excellent agreement with the theory whose approach is general and therefore applicable to gyrotrons operating in any arbitrary cavity mode. (author) 3 figs., 4 refs

Single-stage depressed collectors for gyrotrons

International Nuclear Information System (INIS)

Piosczyk, B.; Iatrou, C.T.; Dammertz, G.; Thumm, M.; Univ. Karlsruhe

1996-01-01

Two 140 GHz gyrotrons with a single-step depressed collector have been operated. The different position of the isolating collector gap in the stray magnetic field causes the electron motion in the retarding region to be in one case adiabatic and in the other case nonadiabatic. The kind of motion within the retarding field influences strongly the behavior of the gyrotron with a depressed collector. In the case of nonadiabatic motion a significant amount of transverse momentum is given to the electrons reflected at the collector potential. This causes the reflected electrons to be trapped between the magnetic mirror and the collector. The electrons escape from the trap by diffusion across the magnetic field to the body of the tube thus contributing to the body current. Despite the high body current there is no observable influence of the collector voltage on the RF output power. In the case of adiabatic motion the reflected electrons do not gain a sufficient amount of transverse momentum to be trapped by the magnetic mirror. They pass the cavity toward the gun and they are trapped between the negative gun potential and the collector. The interaction with the RF field by electrons traveling through the cavity enhances the diffusion in the velocity space thus enabling the trapped electrons to overcome the potential barrier and escape toward the collector. Therefore the body current stays at low values since in this case the reflected electrons do not contribute to it. However, at higher collector voltages a reduction of RF power occurred and some noise in the electron beam was observed. The main motivation for the development of gyrotrons in the frequency range above 100 GHz with power levels in excess of several hundreds kW per tube, is the application in magnetic fusion devices for plasma heating and for electron current drive

Upgrade of a 30 kV/10 mA anode power supply for triode type gyrotron

Energy Technology Data Exchange (ETDEWEB)

Siravo, Ugo, E-mail: ugo.siravo@epfl.ch; Alberti, Stefano; Dubray, Jérémie; Fasel, Damien; Hogge, Jean-Philippe; Marlétaz, Blaise; Marmillod, Philippe; Perez, Albert; Silva, Miguel

2015-10-15

Highlights: • Triode type gyrotron is fed by 3 power supplies: the main, an anode PS(APS) and a heater. • This paper presents the upgrade of 3APS, supplied in 1999, that never fulfilled the specs. • The new working principle is very efficient, easy to implement, for a minimal cost. • Upgraded APS provides extended modulation capabilities, no overshoot and lowerripple. • This upgrade will allow exploring new operation regimes for the 3 TCV X3 gyrotrons. - The RF power of a gyrotron with a triode type magnetron-injection-gun (MIG) can be directly controlled via the voltage applied between its anode and its cathode. Hence, the performance of this type of gyrotron relies directly on the possibilities offered by the power supply controlling the anode to cathode voltage. For a system of gyrotrons connected to the same main high-voltage power supply, with a triode MIG one has the additional advantage of independently controlling each individual gyrotron. This paper presents the modifications brought to the three existing 30 kV/10 mA anode power supplies connected to the 500 kW/118 GHz/2s X3 gyrotrons operated on the TCV Tokamak. The new working principle based on phase-shift modulation (PSM) is described in detail. Experimental results obtained on dummy load are compared to simulations performed during the design phase. With respect to the initial working principle, the modulation frequency capability has been increased by a factor 10 reaching more than 5 kHz, whereas the output voltage ripple as well as the overshoot/undershoot have been significantly reduced.

The Effect of Intermolecular Halogen Bond on 19F DNP Enhancement in 1, 4-Diiodotetrafluorobenzene/4-OH-TEMPO Supramolecular Assembly

Directory of Open Access Journals (Sweden)

GAO Shan

2017-12-01

Full Text Available Halogen bond, as hydrogen bond, is a non-covalent bond. Dynamic nuclear polarization (DNP technique has been used previously to study hydrogen bonds-mediated intermolecular interactions. However, no study has been carried out so far to study the halogen bond-mediated intermolecular interactions with DNP. In this work, 19F DNP polarization efficiency of the halogen bonds existing in supramolecular assembling by 4-OH-TEMPO and 1,4-diiodotetrafluorobenzene (DITFB was studied on a home-made DNP system. The formation of intermolecular halogen bonds appeared to increase 19F DNP polarization efficiency, suggesting that the spin-spin interactions among electrons were weakened by the halogen bonds, resulting in an increased T2e and a larger saturation factor.

A 2 MW, 170 GHz coaxial cavity gyrotron - experimental verification of the design of main components

Energy Technology Data Exchange (ETDEWEB)

Piosczyk, B [Forschungszentrum Karlsruhe, Association EURATOM-FZK, Institut fuer Hochleistungsimpuls- und Mikrowellentechnik (IHM), Postfach 3640, D-76021 Karlsruhe (Germany); Dammertz, G [Forschungszentrum Karlsruhe, Association EURATOM-FZK, Institut fuer Hochleistungsimpuls- und Mikrowellentechnik (IHM), Postfach 3640, D-76021 Karlsruhe (Germany); Dumbrajs, O [Department of Engineering Physics and Mathematics, Helsinki University of Technology, Association EURATOM-TEKES, FIN-02150 Espoo (Finland)] (and others)

2005-01-01

A 2 MW, CW, 170 GHz coaxial cavity gyrotron is under development in cooperation between European Research Institutions (FZK Karlsruhe, CRPP Lausanne, HUT Helsinki) and the European tube industry (TED, Velizy, France). The design of critical components has recently been examined experimentally at FZK Karlsruhe with a short pulse ({approx} few ms) coaxial cavity gyrotron. This gyrotron uses the same cavity and the same quasioptical (q.o.) RF-output system as designed for the industrial prototype and a very similar electron gun.

A quasi-optical and corrugated waveguide microwave transmission system for simultaneous dynamic nuclear polarization NMR on two separate 14.1 T spectrometers.

Science.gov (United States)

Dubroca, Thierry; Smith, Adam N; Pike, Kevin J; Froud, Stuart; Wylde, Richard; Trociewitz, Bianca; McKay, Johannes; Mentink-Vigier, Frederic; van Tol, Johan; Wi, Sungsool; Brey, William; Long, Joanna R; Frydman, Lucio; Hill, Stephen

2018-04-01

Nuclear magnetic resonance (NMR) is an intrinsically insensitive technique, with Boltzmann distributions of nuclear spin states on the order of parts per million in conventional magnetic fields. To overcome this limitation, dynamic nuclear polarization (DNP) can be used to gain up to three orders of magnitude in signal enhancement, which can decrease experimental time by up to six orders of magnitude. In DNP experiments, nuclear spin polarization is enhanced by transferring the relatively larger electron polarization to NMR active nuclei via microwave irradiation. Here, we describe the design and performance of a quasi-optical system enabling the use of a single 395 GHz gyrotron microwave source to simultaneously perform DNP experiments on two different 14.1 T ( 1 H 600 MHz) NMR spectrometers: one configured for magic angle spinning (MAS) solid state NMR; the other configured for solution state NMR experiments. In particular, we describe how the high power microwave beam is split, transmitted, and manipulated between the two spectrometers. A 13 C enhancement of 128 is achieved via the cross effect for alanine, using the nitroxide biradical AMUPol, under MAS-DNP conditions at 110 K, while a 31 P enhancement of 160 is achieved via the Overhauser effect for triphenylphosphine using the monoradical BDPA under solution NMR conditions at room temperature. The latter result is the first demonstration of Overhauser DNP in the solution state at a field of 14.1 T ( 1 H 600 MHz). Moreover these results have been produced with large sample volumes (∼100 µL, i.e. 3 mm diameter NMR tubes). Copyright © 2018 Elsevier Inc. All rights reserved.

Startup methods for single-mode gyrotron operation

International Nuclear Information System (INIS)

Whaley, D.R.; Tran, M.Q.; Alberti, S.; Tran, T.M.; Antonsen, T.M.; Tran, C.

1995-03-01

Experimental results of startup studies on a 118 GHz TE 22,6 gyrotron are presented and compared with theory. The theoretical excitation regimes of competing modes are computed in the energy-velocity-pitch-angle plane near the operation point. The startup paths through the plane are determined by the time evolution of the beam parameters during the startup phase. These startup paths are modified by changing the anode and cathode voltage rise from zero to their nominal values and are seen to determine the cavity oscillating mode. Experimental results show specifically that competition between the TE 22,6 and TE -19,7 mode can be completely eliminated by using the proper startup method in a case where a typical triode startup results in oscillation in the competing TE -19,7 mode. These new results are shown to be in excellent agreement with theory whose approach is general and therefore applicable to gyrotrons operating in any arbitrary cavity mode. (author) 5 figs., 1 tab., 13 refs

Design of the all solid high-voltage power supply for a gyrotron body

Energy Technology Data Exchange (ETDEWEB)

Rao, Yihua [School of Mathematics and Physics, University of South China, Hengyang, 421001 (China); Chen, Wenguang, E-mail: 430000485393@usc.edu.cn [School of Electrical Engineering, University of South China, Hengyang, 421001 (China); Hu, Bo [School of Electrical Engineering, University of South China, Hengyang, 421001 (China); Rao, Jun; Huang, Mei; Kang, Zihua; Feng, Kun [Southwestern Institute of Physics, Chengdu, 610041 (China); Huang, Jiaqi [School of Electrical Engineering, University of South China, Hengyang, 421001 (China)

2017-04-15

Highlights: • Completed design of all solid-state high-voltage power supply for gyrotron body on HL-2M ECRH. • Consist of 58 PSM modules and one BUCK module, controlled by DSP system. • Fabricated full voltage 35 kV, 200 mA BPS and tested in dummy load. • The BPS can operate in three modes: single pulse mode, multi-pulse modulation mode and the six-level preset mode. - Abstract: Gyrotron plays an important role in the research of electron cyclotron resonance heating (ECRH) on Tokomak. The high-frequency switched power supply technology and pulse step modulation (PSM) technology are used in the development of the all solid high-voltage body power supply (BPS) for 1 MW/105 GHz Gyrotron on ECRH system. Firstly, the basic structure of the BPS and its control system are introduced. Secondly, the software control algorithm of voltage stabilization and modulate method are developed. Finally, the design is verified by the experiments. The experimental results of the single pulse mode, the multi-pulse modulation mode and the six-level preset mode, are shown. The output voltage of the power supply can reach 35 kV and the current at about 200 mA, which are adjustable in the full range. The maximum modulation frequency can reach 1 kHz and the front edge of the pulse can be adjust from 0 to 3 ms and the accuracy of the output voltage is less than 100 V. The results show that the control method is feasible and can be applied to other high power microwave sources.

Simulation of Non-Uniform Electron Beams in the Gyrotron Electron-Optical System

Science.gov (United States)

Louksha, O. I.; Trofimov, P. A.

2018-04-01

New calculated data on the effect of emission inhomogeneities on the quality of the electron beam, which is formed in an electron-optical system of a gyrotron, have been obtained. The calculations were based on emission current density distributions, which were measured for the different cathodes in the gyrotron of Peter the Great St. Petersburg Polytechnic University. A satisfactory agreement between the experimental and calculated data on the influence of emission nonuniformities on the velocity spread of electrons has been shown. The necessity of considering the real distribution of the emission current density over the cathode surface to determine the main parameters of the electron beam—the velocity and energy spreads of the electrons, spatial structure of the beam, and coefficient of reflection of electrons from the magnetic mirror—has been demonstrated. The maximum level of emission inhomogeneities, which are permissible for effective work of gyrotrons, has been discussed.

Free-electron masers vs. gyrotrons prospects for high-power sources at millimeter and submillimeter wavelengths

CERN Document Server

Thumm, M K

2002-01-01

The possible applications of high-power millimeter (mm) and sub-mm waves from free-electron masers (FEMs) and gyro-devices span a wide range of technologies. The plasma physics community has already taken advantage of recent advances in applying high-power mm waves generated by long pulse or continuous wave (CW) gyrotron oscillators and short pulse very high-power FEMs in the areas of RF-plasma production, heating, non-inductive current drive, plasma stabilization and active plasma diagnostics for magnetic confinement thermonuclear fusion research, such as electron cyclotron resonance heating (28-170 GHz), electron cyclotron current drive , collective Thomson scattering , microwave transmission and heat-wave propagation experiments. Continuously frequency tunable FEMs could widen these fields of applications. Another important application of CW gyrotrons is industrial materials processing, e.g. sintering of high-performance functional and structural nanostructured ceramics. Sub-mm wave sources are employed in...

Suppression and nonlinear excitation of parasitic modes in second harmonic gyrotrons operating in a very high order mode

International Nuclear Information System (INIS)

Nusinovich, Gregory S.; Pu, Ruifeng; Granatstein, Victor L.

2015-01-01

In recent years, there was an active development of high-power, sub-terahertz (sub-THz) gyrotrons for numerous applications. For example, a 0.67 THz gyrotron delivering more than 200 kW with about 20% efficiency was developed. This record high efficiency was achieved because the gyrotron operated in a high-order TE 31,8 -mode with the power of ohmic losses less than 10% of the power of outgoing radiation. That gyrotron operated at the fundamental cyclotron resonance, and a high magnetic field of about 27 T was created by a pulse solenoid. For numerous applications, it is beneficial to use gyrotrons at cyclotron harmonics which can operate in available cryomagnets with fields not exceeding 15 T. However, typically, the gyrotron operation at harmonics faces severe competition from parasitic modes at the fundamental resonance. In the present paper, we consider a similar 0.67 THz gyrotron designed for operation in the same TE 31,8 -mode, but at the second harmonic. We focus on two nonlinear effects typical for interaction between the fundamental and second harmonic modes, viz., the mode suppression and the nonlinear excitation of the mode at the fundamental harmonic by the second harmonic oscillations. Our study includes both the analytical theory and numerical simulations performed with the self-consistent code MAGY. The simulations show that stable second harmonic operation in the TE 31,8 mode is possible with only modest sacrifice of efficiency and power

Subterahertz gyrotron developments for collective Thomson scattering in LHDa)

Science.gov (United States)

Notake, T.; Saito, T.; Tatematsu, Y.; Kubo, S.; Shimozuma, T.; Tanaka, K.; Nishiura, M.; Fujii, A.; Agusu, La; Ogawa, I.; Idehara, T.

2008-10-01

Collective Thomson scattering (CTS) is expected to provide the spatially resolved velocity distribution functions of not only thermal and tail ions but also alpha particles resulting from fusion reactions. CTS using gyrotrons with frequency higher than the conventional ones used for plasma heating would have advantages to alleviate refraction, cutoff effects, and background electron cyclotron emission noise. Therefore, a high-power pulse gyrotron operating at approximately 400 GHz is being developed for CTS in Large Helical Device (LHD). A single-mode oscillation with a frequency greater than 400 GHz, applying the second-harmonic resonance, was successfully demonstrated in the first stage. At the same time, concrete feasibility study based on ray tracing, scattering spectra, and electron cyclotron emission calculations has been conducted.

75 FR 64694 - Approval for Expanded Manufacturing Authority; Foreign-Trade Subzone 33E; DNP IMS America...

Science.gov (United States)

2010-10-20

... Manufacturing Authority; Foreign-Trade Subzone 33E; DNP IMS America Corporation (Thermal Transfer Ribbon Printer..., grantee of FTZ 33, has requested an expansion of the scope of manufacturing authority on behalf of DNP IMS...-6636, 2/10/2010) and the application has been processed pursuant to the FTZ Act and the Board's...

Gyrotron development at the Instituto de Pesquisas Espaciais

International Nuclear Information System (INIS)

Barroso, J.J.; Castro, P.J. de; Correa, R.A.; Galvao, G.P.; Ludwig, G.O.; Montes, A.; Nono, M.C.A.

1987-07-01

The conceptual design of a 35GHz gyrotron operating in the TE 01 mode, intended for plasma heating experiments, is presented. The electrooptical system is sinthesized from electron beam parameters in the cavity region and the electrodynamical system includes a conventional resonator consisting of truncated cones. The starting and operating characteristics are calculated by integrating the exact equation of electron motion under de action of an RF field with fixed spatial distribution. The experimental activities are concentrated on the construction of a system of magnetic coils, able to generate a 15 KG magnetic induction with a fluctuation of 0.1% over an extension of 13 cm; the manufacture of caerties by using electroforming techniques; and the development of techiques for the construction of electron guns. (author) [pt

High-frequency gyrotrons and their application to tokamak plasma heating

International Nuclear Information System (INIS)

Kreischer, K.E.

1981-01-01

A comprehensive analysis of high frequency (100 to 200 GHz) and high power (> 100 kW) gyrotrons has been conducted. It is shown that high frequencies will be required in order for electron cyclotron radiation to propagate to the center of a compact tokamak power reactor. High power levels will be needed in order to ignite the plasma with a reasonable number of gyrotron units. In the first part of this research, a set of analytic expressions, valid for all TE cavity modes and all harmonics, is derived for the starting current and frequency detuning using the Vlasov-Maxwell equations in the weakly relativistic limit. The use of an optical cavity is also investigated

Enhancement of cadmium bioremediation by endophytic bacterium Bacillus sp. L14 using industrially used metabolic inhibitors (DCC or DNP)

International Nuclear Information System (INIS)

Luo Shenglian; Xiao Xiao; Xi Qiang; Wan Yong; Chen Liang; Zeng Guangming; Liu Chengbin; Guo Hanjun; Chen Jueliang

2011-01-01

Bioremediations of cadmium by endophytic bacterium (EB) L14 (Bacillus sp.) in the presence of industrially used metabolic inhibitors (DCC or DNP) were investigated. In the presence of DCC or DNP, the biomass population of EB L14 was greatly inhibited. However, the cadmium removal of EB L14 increased from 73.6% (in the absence of DCC or DNP) to 93.7% and 80.8%, respectively. The analysis of total and intracellular cadmium concentrations during 24 h of incubation indicated that this enhanced cadmium removal was the inhibition effect of DCC or DNP on the cations export resistance system of EB L14. This unique property strongly indicated the superiority of this endophyte for practical application in cadmium bioremediation in the presence of industrially used metabolic inhibitors.

Development of frequency step tunable 1 MW gyrotron at 131 to 146.5 GHz

Energy Technology Data Exchange (ETDEWEB)

Samartsev, A.; Gantenbein, G.; Dammertz, G.; Illy, S.; Kern, S.; Leonhardt, W.; Schlaich, A.; Schmid, M.; Thumm, M., E-mail: andrey.samartsev@kit.edu [Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany)

2011-07-01

Effective control of power absorption in tokamaks and stellarators could be achieved by the frequency tuning of ECH and CD power delivered by high-power gyrotrons. In this report some results of the development of a frequency tunable gyrotron with fused-silica Brewster window are presented. Excitation of several modes at 1 MW power level in the range of frequencies from 131 to 146.5 GHz is achieved. (author)

MAGY: An innovative high voltage-low current power supply for gyrotron

International Nuclear Information System (INIS)

Siravo, Ugo; Alex, Juergen; Bader, Michael; Carpita, Mauro; Fasel, Damien; Gavin, Serge; Perez, Albert

2011-01-01

From the electrical point of view, the body and the anode of high power gyrotrons behave as capacitive loads. A highly dynamic power supply is, therefore, hard to achieve. The MAGY concept (Modulator for the Anode of a triode type GYrotron) embodies an innovative solution to manage the capacitive current ensuring a very low ripple on the output voltage. It consists of a series of independent, bi-directional and regulated DC sources. Compared to existing topologies, this solution requires a smaller number of power modules. It avoids internal high frequency modulation and simultaneously offers high resolution of the output voltage and a wide range of operating scenarios.

High-harmonic relativistic gyrotron as an alternative to FEL

Energy Technology Data Exchange (ETDEWEB)

Bratman, V L; Kalynov, Yu K; Kolganov, N G; Manuilov, V N; Ofitserov, M M; Samsonov, S V; Volkov, A B [Russian Academy of Sciences, Nizhny Novgorod (Russian Federation). Inst. of Applid Physics

1997-12-31

A submillimeter wave gyrotron operating at moderately relativistic electron energies of 200-300 keV is proposed as a simple alternative to FEL. It is shown that high pulsed magnetic fields of 20-30 T and selective excitation of separate modes for resonances up to the 5-7 th harmonics will make it possible to obtain in a single device the coherent radiation with broadband frequency step tuning within the whole submillimeter wavelength range. At large pitch angles the coupling of the electron beam with cavity modes at higher harmonics should be as strong as at the fundamental one. In order to check the theoretical predictions, two gyrotrons were designed: LOG-1 (250 kV, 10 A, 10 ms) with a thermionic emission cathode and LOG-2 (350 kV, 35 A, 20 ns) with an explosive emission cathode. (J.U.). 7 refs.

DC space-charge induced frequency up-shift in a quasi-optical gyrotron

International Nuclear Information System (INIS)

Alberti, S.; Tran, M.Q.; Tran, T.M.

1990-10-01

Recent experiments on a 100GHz quasi-optical gyrotron have shown that for a large resonator set-up the observed frequency up-shift between the starting current and a current of 10A corresponds to a shift of 4-5 longitudinal modes. In this Letter it is shown that the interpretation of this frequency up-shift should involve the current dependent electron beam voltage depression in the beam tunnel and the interaction region for both the single-mode and multi-mode time evolution codes. (author) 7 refs., 5 figs., 1 tab

First experimental results of the LAP/INPE (Plasma Associated Lab) gyrotron

International Nuclear Information System (INIS)

Barroso, J.J.; Rossi, J.O.; Castro, P.J.; Correa, R.A.; Montes, A.; Ludwig, G.O.; Idehara, T.; Ogawa, I.

1994-01-01

The design and operation of a high power pulsed gyrotron are reported. A magnetron injection gun generates a 5 A, 50 keV helical laminar electron beam with a pitch ratio of 1.5. The electron beam is then placed on the second radial maximum of the T E 02 nominal mode in the resonant cavity. The magnet system comprises three independent water-cooled solenoids located in the gun, cavity and collector regions, consisting of split pair magnets with the field direction vertical. The resonator is a weakly tapered waveguide with a straight section of 0.5 cm in length, a down taper angle of 0.8 0 and an up taper angle of 5 0 The gyrotron runs in pulsed regime with a 20μs pulse length at a frequency repetition rate of 10 Hz and during operation the pressure in the tube is ordinarily less than 4.0 X 10 -7 Torr. Several TE modes were detected over the magnetic field range 9.5 to 12.5 kG and the measured resonant frequencies (29.0 to 32.0 GHz) showed to be in close agreement with the self-consistent calculated values. Experiments are currently under way to measure the absolute output power and to identify the modes through field pattern measurement techniques. (author). 3 refs, 3 figs

Preparation and LSC standardization of ''89 Sr (DNP) using the CIEMAT/NIST method

International Nuclear Information System (INIS)

Rodriguez Barquero, L.; Arcos Merino, J.M. Los; Grau Malonda, A.

1994-01-01

A procedure for preparation of liquid scintillation counting samples of the strontium DNP complex, labelled with ''89 Sr, is described. The chemical quench, the counting stability and spectral evolution of this compound is studied in six scintillators, Toluene, Toluene-alcohol, Dioxane-naphthalene, HiSafe II, Ultima-Gold and Instagel. The liquid scintillation standardization of ''89Sr-DNP by the CIEMAT/NIST method, using Hisafe II and Ultima-Gold scintillators, has been carried out. The discrepancies between experimental and computed efficiencies are lower than 0.38% and 0.48%, respectively. The solution has been standardized in terms of activity concentration to an overall uncertainty of 0.38%. (Author)

Preparation and LSC Standardization of ''89Sr (DNP) Using the CIEMAT/NIST Method

International Nuclear Information System (INIS)

Rodriguez Barquero, L.; Los Arcos Merino, J. M.; Grau Malonda, A.

1994-01-01

A procedure for preparation of liquid scintillation counting samples of the strontium DNP complex, labelled with ''89Sr, is described, the chemical quench, the counting stability and spectral evolution of this compound is studied in six scintillators, Toluene, Toluene-alcohol, Dioxane-naphthalene, HiSafe II, Ultima- Gold and Instagel. The liquid scintillation standardization of 89Sr-DNP by the CIEMAT/NIST method, using HiSafe II and Ultima-Gold scintillators, has been carried out. The discrepancies between experimental and computed efficiencies are lower than 0.38% and 0.48%, respectively. The solution has been standardized in terms of activity concentration to an overall uncertainty of 0,38%. (Author) 10 refs

Suppression criteria of parasitic mode oscillations in a gyrotron beam tunnel

Science.gov (United States)

Kumar, Nitin; Singh, Udaybir; Singh, T. P.; Sinha, A. K.

2011-02-01

This paper presents the design criteria of the parasitic mode oscillations suppression for a periodic, ceramic, and copper loaded gyrotron beam tunnel. In such a type of beam tunnel, the suppression of parasitic mode oscillations is an important design problem. A method of beam-wave coupling coefficient and its mathematical formulation are presented. The developed design criteria are used in the beam tunnel design of a 42 GHz gyrotron to be developed for the Indian TOKAMAK system. The role of the thickness and the radius of the beam tunnel copper rings to obtain the developed design criteria are also discussed. The commercially available electromagnetic code CST and the electron trajectory code EGUN are used for the simulations.

Suppression criteria of parasitic mode oscillations in a gyrotron beam tunnel

International Nuclear Information System (INIS)

Kumar, Nitin; Singh, Udaybir; Sinha, A. K.; Singh, T. P.

2011-01-01

This paper presents the design criteria of the parasitic mode oscillations suppression for a periodic, ceramic, and copper loaded gyrotron beam tunnel. In such a type of beam tunnel, the suppression of parasitic mode oscillations is an important design problem. A method of beam-wave coupling coefficient and its mathematical formulation are presented. The developed design criteria are used in the beam tunnel design of a 42 GHz gyrotron to be developed for the Indian TOKAMAK system. The role of the thickness and the radius of the beam tunnel copper rings to obtain the developed design criteria are also discussed. The commercially available electromagnetic code CST and the electron trajectory code EGUN are used for the simulations.

Effects of electron beam parameters and velocity spread on radio frequency output of a photonic band gap cavity gyrotron oscillator

Energy Technology Data Exchange (ETDEWEB)

Singh, Ashutosh, E-mail: asingh.rs.ece@iitbhu.ac.in [Faculty of Physical Sciences, Institute of Natural Sciences and Humanities, Shri Ramswaroop Memorial University, Lucknow-Deva Road, Uttar Pradesh 225003 (India); Center of Research in Microwave Tubes, Department of Electronics Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005 (India); Jain, P. K. [Center of Research in Microwave Tubes, Department of Electronics Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005 (India)

2015-09-15

In this paper, the effects of electron beam parameters and velocity spread on the RF behavior of a metallic photonic band gap (PBG) cavity gyrotron operating at 35 GHz with TE{sub 041}–like mode have been theoretically demonstrated. PBG cavity is used here to achieve a single mode operation of the overmoded cavity. The nonlinear time-dependent multimode analysis has been used to observe the beam-wave interaction behavior of the PBG cavity gyrotron, and a commercially available PIC code “CST Particle Studio” has been reconfigured to obtain 3D simulation results in order to validate the analytical values. The output power for this typical PBG gyrotron has been obtained ∼108 kW with ∼15.5% efficiency in a well confined TE{sub 041}–like mode, while all other competing modes have significantly low values of power output. The output power and efficiency of a gyrotron depend highly on the electron beam parameters and velocity spread. The influence of several electron beam parameters, e.g., beam voltage, beam current, beam velocity pitch factor, and DC magnetic field, on the PBG gyrotron operations has been investigated. This study would be helpful in optimising the electron beam parameters and estimating accurate RF output power of the high frequency PBG cavity based gyrotron oscillators.

The upgrade of the DIII-D EC system using 120 GHz ITER gyrotrons

International Nuclear Information System (INIS)

Callis, R.W.; Lohr, J.; Gorelov, I.A.; Ponce, D.; Kajiwara, K.; Tooker, J.F.

2005-01-01

The planned growth in the EC system on DIII-D over the next few years requires the installation of two depressed collector gyrotrons, a high voltage power supply, two low loss transmission lines, and the required support equipment. This new DIII-D EC equipment could be made identical to the ITER EC system requirements. By building the DIII-D hardware to the ITER specifications, it will allow ITER to gain beneficial prototyping experience on a working tokamak, prior to committing to building the hardware for delivery to ITER

Towards a 1 MW, 170 GHz gyrotron design for fusion application

Science.gov (United States)

Kumar, Anil; Kumar, Nitin; Singh, Udaybir; Bhattacharya, Ranajoy; Yadav, Vivek; Sinha, A. K.

2013-03-01

The electrical design of different components of 1 MW, 170 GHz gyrotron such as, magnetron injection gun, cylindrical interaction cavity and collector and RF window is presented in this article. Recently, a new project related to the development of 170 GHz, 1 MW gyrotron has been started for the Indian Tokamak. TE34,10 mode is selected as the operating mode after studied the problem of mode competition. The triode type geometry is selected for the design of magnetron injection gun (MIG) to achieve the required beam parameters. The maximum transverse velocity spread of 3.28% at the velocity ratio of 1.34 is obtained in simulations for a 40 A, 80 kV electron beam. The RF output power of more than 1 MW with 36.5% interaction efficiency without depressed collector is predicted by simulation in single-mode operation at 170 GHz frequency. The simulated single-stage depressed collector of the gyrotron predicted the overall device efficiencies >55%. Due to the very good thermal conductivity and very weak dependency of the dielectric parameters on temperature, PACVD diamond is selected for window design for the transmission of RF power. The in-house developed code MIGSYN and GCOMS are used for initial geometry design of MIG and mode selection respectively. Commercially available simulation tools MAGIC and ANSYS are used for beam-wave interaction and mechanical analysis respectively.

Numerical design and analysis of parasitic mode oscillations for 95 GHz gyrotron beam tunnel

Science.gov (United States)

Kumar, Nitin; Singh, Udaybir; Yadav, Vivek; Kumar, Anil; Sinha, A. K.

2013-05-01

The beam tunnel, equipped with the high lossy ceramics, is designed for 95 GHz gyrotron. The geometry of the beam tunnel is optimized considering the maximum RF absorption (ideally 100%) and the suppression of parasitic oscillations. The excitation of parasitic modes is a concerning problem for high frequency, high power gyrotrons. Considering the problem of parasitic mode excitation in beam tunnel, a detail analysis is performed for the suppression of these kinds of modes. Trajectory code EGUN and CST Microwave Studio are used for the simulations of electron beam trajectory and electromagnetic analysis, respectively.

Gyrotron development at the Instituto de Pesquisas Espaciais

International Nuclear Information System (INIS)

Barroso, J.J.; Castro, P.J. de; Correa, R.A.; Galvao, G.P.

1987-01-01

The conceptual design of a 35GHz gyrotron operating in the TE 021 mode, intended for plasma heating experiments, is presented. The electrooptical system is synthesized from the electron beam parameters in the cavity region and the electrodynamical system includes a conventional resonator consisting of truncated cones. The starting and operating characteristics are calculated by integrating the exact equation of electron motion under the action of an RF fiel with fixed spatial distribution. For the moment, the experimental activities, in addition to providing all the infrastructure for the laboratory, are concentrated on the construction of a system of magnetic coils, able to generated a 15kG magnetic induction with a fluctuation of 0.1% over an extension of 13cm, on the manufacture of cavities by using electroforming techniques and on the development of techniques for the construction of electron guns. (author) [pt

Preparation and LSC Standardization of ''89Sr (DNP) Using the CIEMAT/NIST Method; Preparacion del ''89Sr(DNP) y calibracion por centelleo liquido, mediante el metodo CIEMAT/NIST

Energy Technology Data Exchange (ETDEWEB)

Rodriguez Barquero, L.; Los Arcos Merino, J. M.; Grau Malonda, A.

1994-07-01

A procedure for preparation of liquid scintillation counting samples of the strontium DNP complex, labelled with ''89Sr, is described, the chemical quench, the counting stability and spectral evolution of this compound is studied in six scintillators, Toluene, Toluene-alcohol, Dioxane-naphthalene, HiSafe II, Ultima- Gold and Instagel. The liquid scintillation standardization of 89Sr-DNP by the CIEMAT/NIST method, using HiSafe II and Ultima-Gold scintillators, has been carried out. The discrepancies between experimental and computed efficiencies are lower than 0.38% and 0.48%, respectively. The solution has been standardized in terms of activity concentration to an overall uncertainty of 0,38%. (Author) 10 refs.

Experimental study of a 1 MW, 170 GHz gyrotron oscillator

Science.gov (United States)

Kimura, Takuji

A detailed experimental study is presented of a 1 MW, 170 GHz gyrotron oscillator whose design is consistent with the ECH requirements of the International Thermonuclear Experimental Reactor (ITER) for bulk heating and current drive. This work is the first to demonstrate that megawatt power level at 170 GHz can be achieved in a gyrotron with high efficiency for plasma heating applications. Maximum output power of 1.5 MW is obtained at 170.1 GHz in 85 kV, 50A operation for an efficiency of 35%. Although the experiment at MIT is conducted with short pulses (3 μs), the gyrotron is designed to be suitable for development by industry for continuous wave operation. The peak ohmic loss on the cavity wall for 1 MW of output power is calculated to be 2.3 kW/cm2, which can be handled using present cooling technology. Mode competition problems in a highly over-moded cavity are studied to maximize the efficiency. Various aspects of electron gun design are examined to obtain high quality electron beams with very low velocity spread. A triode magnetron injection gun is designed using the EGUN simulation code. A total perpendicular velocity spread of less than 8% is realized by designing a low- sensitivity, non-adiabatic gun. The RF power is generated in a short tapered cavity with an iris step. The operating mode is the TE28,8,1 mode. A mode converter is designed to convert the RF output to a Gaussian beam. Power and efficiency are measured in the design TE28,8,1 mode at 170.1 GHz as well as the TE27,8,1 mode at 166.6 GHz and TE29,8,1 mode at 173.5 GHz. Efficiencies between 34%-36% are consistently obtained over a wide range of operating parameters. These efficiencies agree with the highest values predicted by the multimode simulations. The startup scenario is investigated and observed to agree with the linear theory. The measured beam velocity ratio is consistent with EGUN simulation. Interception of reflected beam by the mod-anode is measured as a function of velocity ratio

Analysis of Mig-type electron guns for a 35GHz gyrotron

International Nuclear Information System (INIS)

Barroso, J.J.; Galvao, G.P.

1988-05-01

A 35GHz gyrotron is currently under construction at the Associated Plasma Laboratory of the Institute for Space Research to be used in plasma heating and noninductive current drive experiments. A critical component of the device is the electrooptical system, which must generate a beam with low velocity spread and high transverse energy. One way to decrease the velocity spread is to use laminar beams. For laminar flow, where the trajectories do not cross, the axial component of the space-charge forces changes sign each half cycle models of magnetron injection guns that produce laminar beams are analyzed and procedures for controlling the pitch angle parameter, which defines the transverse-to-axial electron velocity ratio are investigated. (author)

Feasibility of a dual regime gyrotron

International Nuclear Information System (INIS)

Sawant, Ashwini; Jain, Prerit; Kartikeyan, M.V.

2012-01-01

The design concept of a 42/84 GHz, 500 kW, CW, dual-regime gyrotron for ECRH of plasma in an experimental Tokamak will be presented in this paper. Operation at 42 GHz is fundamental where as that in 84 GHz will be second harmonic so that a similar guidance system will be retained for dual regime operation. In this paper, the mode competition and mode selection procedures are presented for such a dual regime operation. Cold cavity design and self-consistent calculations will be carried out for power and efficiencies. (author)

Design and experimental investigation of a second harmonic 20 kW class 28 GHz gyrotron for evaluation of new emitter technologies

Energy Technology Data Exchange (ETDEWEB)

Malygin, Anton

2016-07-01

Gyrotrons are high-power mm-wave tubes. Here, the design, construction and experimental investigation of a 20 kW, 28 GHz gyrotron (2nd harmonic) are reported. This tube was designed to evaluate new emitters for future highly efficient and reliable fusion gyrotrons and for material processing applications. Following experimental results have been achieved in CW operation: 22.5 kW output power at 23.4 kV electron beam voltage and 2.23 A beam current with the world record efficiency of 43 %.

Stability analysis of a coaxial-waveguide gyrotron traveling-wave amplifier

International Nuclear Information System (INIS)

Hung, C.L.; Yeh, Y.S.

2005-01-01

The gyrotron traveling-wave tube (gyro-TWT) amplifier is known to be highly susceptible to spurious oscillations. This study develops a simulation approach to analyze the stability of a coaxial-waveguide gyro-TWT with distributed wall losses. The interplay among the absolute instabilities, the gyrotron backward-wave oscillations, and the circuit parameters is analyzed. Simulation results reveal that the distributed wall losses effectively stabilize spurious oscillations in the coaxial gyro-TWT. Furthermore, the wall resistivity of the center conductor is shown to be an additional effective mechanism for suppressing oscillations. Under stable operation conditions, the coaxial gyro-TWT with distributed losses is predicted to generate 435 kW in the Ka band with 31% efficiency, a saturated gain of 45 dB, and a bandwidth of 1.86 GHz (≅5.8%) for a 70 kV, 20 A electron beam with an α(=ν perpendicular )/ν z )=1.0 and an axial velocity spread of Δν z /ν z =5%

Final Report for 'Gyrotron Design and Evaluation using New Particle-in-Cell Capability'

International Nuclear Information System (INIS)

Smithe, David N.

2008-01-01

ITER will depend on high power CW gyrotrons to deliver power to the plasma at ECR frequencies. However, gyrotrons can suffer from undesirable low frequency oscillations (LFO's) which are known to interfere with the gun-region diagnostics and data collection, and are also expected to produce undesirable energy and velocity spread in the beam. The origins and processes leading to these oscillations are poorly understood, and existing gyrotron R and D tools, such as static gun solvers and interaction region models, are not designed to look at time-dependant oscillatory behavior. We have applied a time-domain particle-in-cell method to investigate the LFO phenomenon. Our company is at the forefront of smooth-curved-boundary treatment of the electromagnetic fields and particle emission surfaces, and such methods are necessary to simulate the adiabatically trapped and reflected electrons thought to be driving the oscillations. This approach provides the means for understanding, in microscopic detail, the underlying physical processes driving the low-frequency oscillations. In the Phase I project, an electron gun region from an existing gyrotron, known to observe LFO's, was selected as a proof-of-principle geometry, and was modeled with the curved-geometry time-domain simulation tool, in order to establish the feasibility of simulating LFO physics with this tool on office-scale, and larger, parallel cluster computers. Generally, it was found to be feasible to model the simulation geometry, emission, and magnetic features of the electron gun. Ultimately, the tool will be used to investigate the origins and life cycle within the trapped particle population. This tool also provides the foundations and validation for potential application of the software to numerous other time-dependant beam and rf source problems in the commercial arena.

Design, Development & Functional Validation of Magnets system in support of 42 GHz Gyrotron in India

Directory of Open Access Journals (Sweden)

Pradhan S.

2017-01-01

Full Text Available A multi institutional initiative is underway towards the development of 42 GHz, 200 kW gyrotron system in India under the frame work of Department of Science and Technology, Government of India. Indigenous realization comprising of design, fabrication, prototypes and functional validations of an appropriate Magnet System is one of the primary technological objective of these initiatives. The 42 GHz gyrotron magnet system comprises of a warm gun magnet, a NbTi/Cu based high homogenous superconducting cavity magnet and three warm collector magnets. The superconducting cavity magnet has been housed inside a low loss cryostat. The magnet system has been designed in accordance with gyrotron physics and engineering considerations respecting highly homogenous spatial field profile as well as maintaining steep gradient as per the compression and velocity ratios between the emission and resonator regions. The designed magnet system further ensures the co-linearity of the magnetic axis with that of the beam axis with custom winding techniques apart from a smooth collection of beam with the collector magnet profiles. The designed magnets have been wound after several R & D validations. The superconducting magnet has been housed inside a low loss designed cryostat with in-built radial and axial alignment flexibilities to certain extent. The cryostat further houses liquid helium port, liquid nitrogen ports, current communication ports, ports for monitoring helium level and other instrumentations apart from over-pressure safety intensive burst disks etc. The entire magnet system comprising of warm and superconducting magnets has been installed and integrated in the Gyrotron test set-up. The magnet system has been aligned in both warm and when the superconducting cavity magnet is cold. The integrated geometric axes have been experimentally ensured as well as the field profiles have been measured with the magnets being charged. Under experimental conditions

Problem-Oriented Simulation Packages and Computational Infrastructure for Numerical Studies of Powerful Gyrotrons

International Nuclear Information System (INIS)

Damyanova, M; Sabchevski, S; Vasileva, E; Balabanova, E; Zhelyazkov, I; Dankov, P; Malinov, P

2016-01-01

Powerful gyrotrons are necessary as sources of strong microwaves for electron cyclotron resonance heating (ECRH) and electron cyclotron current drive (ECCD) of magnetically confined plasmas in various reactors (most notably ITER) for controlled thermonuclear fusion. Adequate physical models and efficient problem-oriented software packages are essential tools for numerical studies, analysis, optimization and computer-aided design (CAD) of such high-performance gyrotrons operating in a CW mode and delivering output power of the order of 1-2 MW. In this report we present the current status of our simulation tools (physical models, numerical codes, pre- and post-processing programs, etc.) as well as the computational infrastructure on which they are being developed, maintained and executed. (paper)

Herramientas DNP3 pentesting para redes de infraestructura critica

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M. Sánchez

2016-07-01

Full Text Available Este artículo presenta un conjunto de herramientas de software que son capaces de realizar actividades Pentesting en la infraestructura crítica del sector eléctrico mediante el protocolo DNP3. Las herramientas son capaces de comprobar la capacidad de los controles de seguridad cibernética en el interior del perímetro de la red para evitar cualquier comando sensible falsificado pueda llegar a cualquier controlador de subestación

Development and simulation of RF components for high power millimeter wave gyrotrons

Energy Technology Data Exchange (ETDEWEB)

Pereyaslavets, M.; Sato, M.; Shimozuma, T.; Takita, Y.; Idei, H.; Kubo, S.; Ohkubo, K.; Hayashi, K.

1996-11-01

To test gyrotron RF components, efficient low-power generators for rotating high-order modes of high purity are necessary. Designs of generators for the TE{sub 15,3} mode at 84 GHz and for the TE{sub 31,8} mode at 168 GHz are presented and some preliminary test results are discussed. In addition, Toshiba gyrotron cavities at 168 GHz were analyzed for leakage of RF power in the beam tunnel. To decrease RF power leakage, the declination angle of the cut-off cavity cross section has to be decreased. A TE{sub 15,3} waveguide nonlinear uptaper is analyzed at 84 GHz as well as 168 GHz uptapers. Since the calculated conversion losses are slightly higher than designed value, an optimization of those uptapers may be required. (author)

Studies of self-consistent field structure in a quasi-optical gyrotron

International Nuclear Information System (INIS)

Antonsen, T.M. Jr.

1993-04-01

The presence of an electron beam in a quasi-optical gyrotron cavity alters the structure of the fields from that of the empty cavity. A computer code has been written which calculates this alteration for either an electron beam or a thin dielectric tube placed in the cavity. Experiments measuring the quality factor of such a cavity performed for the case of a dielectric tube and the results agree with the predictions of the code. Simulations of the case of an electron beam indicate that self-consistent effects can be made small in that almost all the power leaves the cavity in a symmetric gaussian-like mode provided the resonator parameters are chosen carefully. (author) 6 figs., 1 tab., 13 refs

Feasibility study of the EU home team on a 170 GHz 1 MW CW gyrotron for ECH on ITER

International Nuclear Information System (INIS)

Iatrou, C.T.; Kern, S.; Thumm, M.; Moebius, A.; Nickel, H.U.; Horajitra, P.; Wien, A.; Tran, T.M.; Bon Mardion, G.; Pain, M.; Tonon, G.

1995-03-01

The gyrotron system for ECH and burn control on ITER requires at least 50 MW of RF power at frequencies near 170 GHz operating in CW. To meet these requirements, high efficiency gyrotron tubes with ≥1 MW power output capability are necessary, as well as simple coupling to either a quasi-optical or waveguide transmission line. The paper reports the feasibility study on the design of an ITER-relevant gyrotron oscillator at 170 GHz, 1 MW CW employing a diode electron gun, an advanced internal quasi-optical converter, a cryogenically cooled single disk sapphire window, and a depressed potential collector. The operating mode selection and the cavity design is a compromise between many design constraints. (author) 18 figs., 6 tabs., 21 refs

Control of generation spectrum of gyrotron with external reflection in mode of several longitudinal modes

International Nuclear Information System (INIS)

Rozental', R.M.; Ginzburg, N.S.; Zajtsev, N.I.; Ilyakov, E.V.; Kulagin, I.S.

2006-01-01

One studies possibility to control the spectrum of multiparticle generation in a gyrotron due to application of external reflections. It is shown that in self-modulation regimes of generation the radiation spectrum lines may be close to the resonance frequencies throughout electrodynamic system covering a part of output waveguide restricted by a reflector. Under the mentioned conditions variation of distance between mode frequencies and, respectively, period of self-modulation may be reached due to varying of position of the reflector. The theory deductions are supported by the results of experimental investigation into 30 GHz region relativistic gyrotron with external reflections [ru

Design and operation of 140 GHz gyrotron oscillators for power levels up to 1 MW CW

Energy Technology Data Exchange (ETDEWEB)

Jory, H.; Bier, R.; Craig, L.J.; Felch, K.; Ives, L.; Lopez, N.; Spang, S.

1986-12-01

Varian has designed and tested 140 GHz gyrotron oscillators that have generated output powers of 100 kW CW and 200 kW for 1 ms pulses. Upcoming tubes will be designed to operate at power levels of 200 kW CW and ultimately up to 1 MW CW. The important design considerations which are addressed in the higher power tubes include the design of the electron gun, interaction circuit, and output window. These issues will be discussed and the results of the earlier 140 GHz gyrotron work at Varian will be summarized.

Design and operation of 140 GHz gyrotron oscillators for power levels up to 1 MW CW

International Nuclear Information System (INIS)

Jory, H.; Bier, R.; Craig, L.J.; Felch, K.; Ives, L.; Lopez, N.; Spang, S.

1986-12-01

Varian has designed and tested 140 GHz gyrotron oscillators that have generated output powers of 100 kW CW and 200 kW for 1 ms pulses. Upcoming tubes will be designed to operate at power levels of 200 kW CW and ultimately up to 1 MW CW. The important design considerations which are addressed in the higher power tubes include the design of the electron gun, interaction circuit, and output window. These issues will be discussed and the results of the earlier 140 GHz gyrotron work at Varian will be summarized

Cell Type Preference of a Novel Human Derived Cell-Permeable Peptide dNP2 and TAT in Murine Splenic Immune Cells.

Directory of Open Access Journals (Sweden)

Sangho Lim

Full Text Available Cell-permeable peptides (CPPs have been widely studied as an attractive drug delivery system to deliver therapeutic macromolecules such as DNA, RNA, and protein into cells. However, its clinical application is still limited and controversial due to the lack of a complete understanding of delivery efficiency in target cells. Previously we identified and characterized the novel and superior CPP, named dNP2, and here we comparatively analyzed intracellular delivery efficiency of dNP2 and TAT in various immune cells of mouse spleen to demonstrate their cell type preference. dNP2- or TAT-conjugated fluorescent proteins were most efficiently taken up by phagocytic cells such as dendritic cells and macrophages while little protein uptake was seen by lymphocytes including T cells, B cells, and NK cells. Interestingly CD8+ lymphoid dendritic cells and CD62LloCD44hi memory like T cell subsets showed significantly better uptake efficiency in vitro and in vivo relative to other dendritic cells or T cells, respectively. In addition, activated macrophages, T cells, and B cells took up the proteins more efficiently relative to when in the resting state. Importantly, only dNP2, not TAT, shows significant intracellular protein delivery efficiency in vivo. Collectively, this study provides important information regarding heterogeneous intracellular delivery efficiency of CPPs such as dNP2 and TAT with cell type preference in the spleen needed for its application in phagocytic cells or activated immune cells.

Parasitic oscillation in and suppression of a gyro BW mode in a low-Q 8 GHz gyrotron

International Nuclear Information System (INIS)

Muggli, P.; Tran, M.Q.; Tran, T.M.

1991-12-01

The parasitic oscillation of the TE o 21 gyrotron Backward Wave (gyro BW) mode is observed in a low-Q, 8 GHz TE o 011 gyrotron. Although at low power (P BW o 011 mode efficiency of less than 0.25. The parasitic oscillation is suppressed by operating the gyrotron with a negative magnetic field gradient along the electron beam, which allows the maximum efficiency to reach 0.40 and the output power to be multiplied by a factor varying from 1.4 to 1.7. The optimum efficiency curve of the TE o 011 mode indicates that the low-Q cavity behaves as a much higher Q diff cavity. Too large magnetic field gradient and α values favour the TE o 012 longitudinal mode, which oscillates in place of the TE o 011 mode and limits its maximum output power. This competitive process is responsible for the high-Q like output power. (author) 14 figs., 14 refs

Would You Use It With a Seal of Approval? Important Attributes of 2,4-Dinitrophenol (2,4-DNP as a Hypothetical Pharmaceutical Product

Directory of Open Access Journals (Sweden)

Emma E. Bleasdale

2018-04-01

Full Text Available Background2,4-Dinitrophenol (2,4-DNP is an effective but highly dangerous fat burner, not licensed for human consumption. Death cases reported for 2,4-DNP overdose, particularly among young adults, have raised concerns about the ineffective regulatory control, lack of education and risks associated with impurity, and the unknown concentration of 2,4-DNP purchased on the Internet.MethodsUsing a sequential mixed method design and based on a hypothetical scenario as if 2,4-DNP was a licensed pharmaceutical drug, first we conducted a qualitative study to explore what product attributes people consider when buying a weight-loss aid. Focus group interviews with six females and three males (mean age = 21.6 ± 1.8 years were audiorecorded, transcribed verbatim, and subjected to thematic analysis. Sixteen attributes were identified for the Best–Worst Scale (BWS in the quantitative survey with 106 participants (64% female, mean age = 27.1 ± 11.9 years, focusing on 2,4-DNP. Demographics, weight satisfaction, and risk for eating disorder data were collected.ResultsIn contrast to experienced users such as bodybuilders, our study participants approached 2,4-DNP cautiously. Attributes of 2,4-DNP as a hypothetical weight-loss drug comprised a range of desirable and avoidable features. Of the 16 selected attributes, BWS suggested that long-term side effects were the most and branding was the least important attribute. Effectiveness and short-term side effects were also essential. Those in the >25 year group showed least concerns for legality. Neutral BWS scores for cost, treatment, degree of lifestyle changes required, and specificity required for the hypothetical weight-loss drug to be effective were likely caused by disagreement about their importance among the participants, not indifference.ConclusionWith advances in research, 2,4-DNP as a pharmaceutical drug in the future for treating neurodegenerative diseases and potentially for

Would You Use It With a Seal of Approval? Important Attributes of 2,4-Dinitrophenol (2,4-DNP) as a Hypothetical Pharmaceutical Product.

Science.gov (United States)

Bleasdale, Emma E; Thrower, Sam N; Petróczi, Andrea

2018-01-01

2,4-Dinitrophenol (2,4-DNP) is an effective but highly dangerous fat burner, not licensed for human consumption. Death cases reported for 2,4-DNP overdose, particularly among young adults, have raised concerns about the ineffective regulatory control, lack of education and risks associated with impurity, and the unknown concentration of 2,4-DNP purchased on the Internet. Using a sequential mixed method design and based on a hypothetical scenario as if 2,4-DNP was a licensed pharmaceutical drug, first we conducted a qualitative study to explore what product attributes people consider when buying a weight-loss aid. Focus group interviews with six females and three males (mean age = 21.6 ± 1.8 years) were audiorecorded, transcribed verbatim, and subjected to thematic analysis. Sixteen attributes were identified for the Best-Worst Scale (BWS) in the quantitative survey with 106 participants (64% female, mean age = 27.1 ± 11.9 years), focusing on 2,4-DNP. Demographics, weight satisfaction, and risk for eating disorder data were collected. In contrast to experienced users such as bodybuilders, our study participants approached 2,4-DNP cautiously. Attributes of 2,4-DNP as a hypothetical weight-loss drug comprised a range of desirable and avoidable features. Of the 16 selected attributes, BWS suggested that long-term side effects were the most and branding was the least important attribute. Effectiveness and short-term side effects were also essential. Those in the >25 year group showed least concerns for legality. Neutral BWS scores for cost, treatment, degree of lifestyle changes required, and specificity required for the hypothetical weight-loss drug to be effective were likely caused by disagreement about their importance among the participants, not indifference. With advances in research, 2,4-DNP as a pharmaceutical drug in the future for treating neurodegenerative diseases and potentially for weight loss is not inconceivable. Caution is

A Parametric Study on the Immunomodulatory Effects of Electroacupuncture in DNP-KLH Immunized Mice

Directory of Open Access Journals (Sweden)

Sun Kwang Kim

2011-01-01

Full Text Available This study was conducted to compare the effects of low frequency electroacupuncture (EA and high frequency EA at acupoint ST36 on the production of IgE and Th1/Th2 cytokines in BALB/c mice that had been immunized with 2,4-dinitrophenylated keyhole limpet protein (DNP-KLH, as well as to investigate the difference in the immunomodulatory effects exerted by EA stimulations at acupoint ST36 and at a non-acupoint (tail. Female BALB/c mice were divided into seven groups: normal (no treatments, IM (immunization only, ST36-PA (IM + plain acupuncture at ST36, ST36-LEA (IM + low frequency (1 Hz EA at ST36, ST36-HEA (IM + high frequency (120 Hz EA at ST36, NA-LEA (IM + low frequency (1 Hz EA at non-acupoint and NA-HEA (IM + high frequency (120 Hz EA at non-acupoint. EA stimulation was performed daily for two weeks, and total IgE, DNP-KLH specific IgE, IL-4 and IFN-γ levels were measured at the end of the experiment. The results of this study showed that the IgE and IL-4 levels were significantly suppressed in the ST36-LEA and ST36-HEA groups, but not in the NA-LEA and NA-HEA groups. However, there was little difference in the immunomodulatory effects observed in the ST36-LEA and ST36-HEA groups. Taken together, these results suggest that EA stimulation-induced immunomodulation is not frequency dependent, but that it is acupoint specific.

Synthesis of mig-type electron guns for gyrotrons

International Nuclear Information System (INIS)

Castro, J.J.B. de; Montes, A.; Silva, C.A.B.

1984-01-01

A synthesis method is used in the design of axially symmetrical guns in the moderate to high space charge regime. Self-consistent equations for the temperature limited emission case are used to represent the beam and solve the internal problem, under the requirement of laminar flow. The external problem is solved by integrating the equations with boundary conditions defined by the analytically extended solutions of the internal problem. This technique will be used in the development of INPE's gyrotron. (Author) [pt

New window materials for high power gyrotron

International Nuclear Information System (INIS)

Afsar, M.N.; Hua Chi

1993-01-01

A single free standing synthetic diamond window seems to have higher absorption coefficient value at millimeter wavelength region at this time although it is claimed that it possesses good mechanical strength and higher thermal conductivity characteristics. It certainly does not rule out the use of diamond film on single crystal high resistivity silicon to improve its mechanical strength and thermal conductivity. One may have to use an appropriate film thickness for a particular wavelength in gyrotron window application. It is also necessary to use an appropriate thickness for the silicon perhaps equivalent to a quaterwavelength in order to avoid the reflection mismatch

Upgrade Of The TH1506B 118 GHz Gyrotron Using Modeing Tools

International Nuclear Information System (INIS)

Darbos, C.; Bouquey, F.; Lambert, R.; Magne, R.; Traisnel, E.; Arnold, A.; Prinz, H. O.; Thumm, M.; Hogge, J. P.; Lievin, C.

2007-01-01

The first TH1506B prototype showing problems of overheating and spurious oscillations, a new modified gyrotron was built. During the tests, the extwo peaks, which was never predicted by simulations. Various low evel tests were performed on the mode converter with different shapes for the launcher but without real improvement. Besides measurements, the use of a new software Surf3D[l] showed that the problem mainly comes from the 3rd mirror whose curvature is too high and not well taken nto account by the calculation. This analysis software is based on ntegral equations and the complete 3D modelling alowed to determine a new profile for the 3rd mirror. An aluminium model of a new mirror was manufactured and thorough low level tests made at FZK showed that there was no double peak.The next step would consist in building a gyrotron based on this new design, to confirm the simulation and to valdate it for long pulses

Proton polarization above 70% by DNP using photo-excited triplet states, a first step towards a broadband neutron spin filter

International Nuclear Information System (INIS)

Eichhorn, T.R.; Niketic, N.; Brandt, B. van den; Filges, U.; Panzner, T.; Rantsiou, E.; Wenckebach, W.Th.; Hautle, P.

2014-01-01

The use of polarized protons as neutron spin filter is an attractive alternative to the well established neutron polarization techniques, as the large, spin-dependent neutron scattering cross-section for protons is useful up to the sub-MeV region. Employing optically excited triplet states for the dynamic nuclear polarization (DNP) of the protons relieves the stringent requirements of classical DNP schemes, i.e low temperatures and strong magnetic fields, making technically simpler systems with open geometries possible. Using triplet DNP a record polarization of 71% has been achieved in a pentacene doped naphthalene single crystal at a field of 0.36 T using a simple helium flow cryostat for cooling. Furthermore, by placing the polarized crystal in a neutron optics focus and de-focus scheme, the actual sample cross-section could be increased by a factor 35 corresponding to an effective spin filter cross-section of 18×18mm 2

Proton polarization above 70% by DNP using photo-excited triplet states, a first step towards a broadband neutron spin filter

Energy Technology Data Exchange (ETDEWEB)

Eichhorn, T.R. [Laboratory for Developments and Methods (LDM), Paul Scherrer Institute, CH-5232 Villigen PSI (Switzerland); Laboratory of Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne (Switzerland); Niketic, N.; Brandt, B. van den; Filges, U.; Panzner, T.; Rantsiou, E.; Wenckebach, W.Th. [Laboratory for Developments and Methods (LDM), Paul Scherrer Institute, CH-5232 Villigen PSI (Switzerland); Hautle, P., E-mail: patrick.hautle@psi.ch [Laboratory for Developments and Methods (LDM), Paul Scherrer Institute, CH-5232 Villigen PSI (Switzerland)

2014-08-01

The use of polarized protons as neutron spin filter is an attractive alternative to the well established neutron polarization techniques, as the large, spin-dependent neutron scattering cross-section for protons is useful up to the sub-MeV region. Employing optically excited triplet states for the dynamic nuclear polarization (DNP) of the protons relieves the stringent requirements of classical DNP schemes, i.e low temperatures and strong magnetic fields, making technically simpler systems with open geometries possible. Using triplet DNP a record polarization of 71% has been achieved in a pentacene doped naphthalene single crystal at a field of 0.36 T using a simple helium flow cryostat for cooling. Furthermore, by placing the polarized crystal in a neutron optics focus and de-focus scheme, the actual sample cross-section could be increased by a factor 35 corresponding to an effective spin filter cross-section of 18×18mm{sup 2}.

Isolation of a high malic and low acetic acid-producing sake yeast Saccharomyces cerevisiae strain screened from respiratory inhibitor 2,4-dinitrophenol (DNP)-resistant strains.

Science.gov (United States)

Kosugi, Shingo; Kiyoshi, Keiji; Oba, Takahiro; Kusumoto, Kenichi; Kadokura, Toshimori; Nakazato, Atsumi; Nakayama, Shunichi

2014-01-01

We isolated 2,4-dinitrophenol (DNP)-resistant sake yeast strains by UV mutagenesis. Among the DNP-resistant mutants, we focused on strains exhibiting high malic acid and low acetic acid production. The improved organic acid composition is unlikely to be under the control of enzyme activities related to malic and acetic acid synthesis pathways. Instead, low mitochondrial activity was observed in DNP-resistant mutants, indicating that the excess pyruvic acid generated during glycolysis is not metabolized in the mitochondria but converted to malic acid in the cytosol. In addition, the NADH/NAD(+) ratio of the DNP-resistant strains was higher than that of the parental strain K901. These results suggest that the increased NADH/NAD(+) ratio together with the low mitochondrial activity alter the organic acid composition because malic acid synthesis requires NADH, while acetic acid uses NAD(+). Copyright © 2013 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Development of Gyrotron and JT-60U EC heating system for fusion reactor

International Nuclear Information System (INIS)

Sakamoto, K.; Kasugai, A.; Ikeda, Yo.

2003-01-01

The progress of ECH technology, for ITER and JT-60U tokamak, are presented. In the development of gyrotron, 0.9MW/9.2sec, 0.5MW/30sec, 0.3MW/60sec, etc. have been demonstrated at 170GHz. At 110GHz, 1.3MW/1.2sec, 1.2MW/4.1sec, 1MW/5sec were obtained. It is found that the reduction of the stray radiation and the enhancement of cooling capability are keys for CW operation. Four 110GHz gyrotrons are under operation in the ECH system of JT-60U. The power up to approximately 3MW/2.7sec was injected into the plasma through the poloidally movable mirrors, and contributed to the electron heating up to 26keV(n e ∼0.5x10 13 cm -3 ), and the suppression of the neo-classical tearing mode. (author)

Development of gyrotron and JT-60U EC heating system for fusion reactor

International Nuclear Information System (INIS)

Sakamoto, K.; Kasugai, A.; Ikeda, Yo.

2003-01-01

The progress of ECH technology, for ITER and JT-60U tokamak, are presented. In the development of gyrotron, 0.9MW/9.2sec, 0.5MW/30sec, 0.3MW/60sec, etc. have been demonstrated at 170GHz. At 110GHz, 1.3MW/1.2sec, 1.2MW/4. 1sec. 1MW/5sec were obtained. It is found that the reduction of the stray radiation and the enhancement of cooling capability are keys for CW operation. Four 110GHz gyrotrons are under operation in the ECH system of JT-60U. The power up to approximately 3MW/2.7sec was injected into the plasma through the poloidally movable mirrors, and contributed to the electron heating up to 26keV(n e ∼0.5x10 13 cm -3 ), and the suppression of the neo-classical tearing mode. (author)

Particle-in-cell analysis of beam-wave interaction in gyrotron cavity with tapered magnetic field

Energy Technology Data Exchange (ETDEWEB)

Kumar, A., E-mail: anil.gyrotron@gmail.com [Gyrotron Lab., Microwave Tube Area, Central Electronics Engineering Research Inst. (CEERI, CSIR), Pilani, Rajasthan (India); Banasthali Univ., Dept. of Physics, Banasthali, Rajasthan (India); Khatun, H.; Kumar, N.; Singh, U.; Sinha, A.K. [Gyrotron Lab., Microwave Tube Area, Central Electronics Engineering Research Inst. (CEERI, CSIR), Pilani, Rajasthan (India); Vyas, V. [Banasthali Univ., Dept. of Physics, Banasthali, Rajasthan (India)

2010-11-15

A commercially available electromagnetic simulator -- MAGIC, a particle-in-cell (PIC) code -- has been used to carry out a comparative study of the beam-wave interaction under uniform and tapered magnetic field profiles of a 42 GHz, 200kW gyrotron. The magnetic field profile across the resonant cavity varies by ±6.5% with a peak value of 1.615 T. The MAGIC simulation shows the desire performance of the gyrotron under both magnetic field conditions with an operating mode TE{sub 03} and a pitch factor of 1.26. The analysis of the simulated results show that stability in the power growth was reached more quickly and achieved higher output power in the case of a tapered magnetic field. (author)

A high-voltage equipment (high voltage supply, high voltage pulse generators, resonant charging inductance, synchro-instruments for gyrotron frequency measurements) for plasma applications

International Nuclear Information System (INIS)

Spassov, Velin

1996-01-01

This document reports my activities as visitor-professor at the Gyrotron Project - INPE Plasma Laboratory. The main objective of my activities was designing, construction and testing a suitable high-voltage pulse generator for plasma applications, and efforts were concentrated on the following points: Design of high-voltage resonant power supply with tunable output (0 - 50 kV) for line-type high voltage pulse generator; design of line-type pulse generator (4 microseconds pulse duration, 0 - 25 kV tunable voltage) for non linear loads such as a gyrotron and P III reactor; design of resonant charging inductance for resonant line-type pulse generator, and design of high resolution synchro instrument for gyrotron frequency measurement. (author)

Quasi-optical mode converter for a coaxial cavity gyrotron

International Nuclear Information System (INIS)

Jin, J.

2007-03-01

This work concentrates on the synthesis of the quasioptical mode converter for the 170 GHz, TE 34,19 -mode, 2MW, CW coaxial-cavity gyrotron at Forschungszentrum Karlsruhe (FZK). The improvement of the general method for the design of so-call dimpled-wall launcher to provide a good Gaussian mode content is described. This method is verified through the design of a launcher operating in the TE 22,6 mode at 118 GHz. A phase rule is proposed as a quality criterion for monitoring the optimization and the choices of parameters of the quasi-optical mode converter. High-order harmonics introduced to the launcher wall deformations are proposed for this gyrotron. The launcher is numerically optimized, the fields on the cut edges are suppressed. The fields in the launcher are well approximated by the waveguide modes, the radiated fields are calculated using the scalar diffraction integral. The procedure for the numerical optimization of the mirror system is improved, the tolerance conditions of the phase correcting mirrors are investigated. A conversion efficiency of 95.8% to the circular fundamental Gaussian distribution with 20mm beam waist and power transmission of 90% are achieved in the window plane using the optimized quasi-optical mode converter. The methods to ameliorate the initial conditions of the phase correcting mirrors are explored. (orig.)

Effects of INH, DNP, 2,4-D and CMU on the photosynthetic activity of barley and maize plants

International Nuclear Information System (INIS)

Fernandez, J.; Prieto, M. P.

1979-01-01

Determinations of the rate of photosynthesis were made in barley and maize leaves treated with INH, DNP, 2,4-D or CMU. 1 ppm of the chemicals in nutritive solutions was absorbed by roots during 24 or 48 hours in both dark and light conditions. After this period, photosynthetic activity, compensation point and 14 C O 2 assimilation were determined. Results show that INH increases the rate of photosynthesis, DNP and 2,4-D do not alter it sensibly and CMU acts as a strong inhibitor of photosynthesis. Some possible applications for ths obtention of labelled compounds by biosynthesis are discussed. (Author) 87 refs

Design and simulation of a ~390 GHz seventh harmonic gyrotron using a large orbit electron beam

Science.gov (United States)

Li, Fengping; He, Wenlong; Cross, Adrian W.; Donaldson, Craig R.; Zhang, Liang; Phelps, Alan D. R.; Ronald, Kevin

2010-04-01

A ~390 GHz harmonic gyrotron based on a cusp electron gun has been designed and numerically modelled. The gyrotron operates at the seventh harmonic of the electron cyclotron frequency with the beam interacting with a TE71 waveguide mode. Theoretical as well as numerical simulation results using the 3D particle-in-cell code MAGIC are presented. The cusp gun generated an axis-encircling, annular shaped electron beam of energy 40 keV, current 1.5 A with a velocity ratio α of 3. Smooth cylindrical waveguides have been studied as the interaction cavities and their cavity Q optimized for 390 GHz operation. In the simulations ~600 W of output power at the design frequency has been demonstrated.

Study of a cylindrical cavity gyrotron, influence of power reflection and of the oscillation of a travelling mode

International Nuclear Information System (INIS)

Muggli, P.

1991-11-01

The quality factor and oscillating mode of a gyrotron cavity are essential parameters to consider when trying to obtain a high power (>500 kW), high efficiency (∼50%) microwave source, which oscillates in a stable manner in the principal mode of the cavity. The study and development of an 8 GHz gyrotron whose resonant cavity is formed by a cylindrical waveguide of slowly varying radius, is undertaken. The study is principally concerned with the phenomena associated with the low quality factor of the TE o 011 mode of the cavity. (author) figs., tabs., 102 refs

Novel dielectric photonic-band-gap resonant cavity loaded in a gyrotron

International Nuclear Information System (INIS)

Chen Xiaoan; Liu Gaofeng; Tang Changjian

2010-01-01

A novel resonant cavity composed of a periodic, multilayer, dielectric photonic crystal is proposed. Using the transfer matrix method and the Bloch theorem for periodic systems, an analysis on the band-gap property of such a structure is made, and the basic electromagnetic property of the photonic-band-gap resonant cavity (PBGC) is preliminarily exhibited. The theoretical studies and the cold cavity simulation results obtained from a high-frequency structure simulator are presented. On the basis of the present research, such a PBGC is quite similar to the two-dimensional PBGC made of triangular lattices of metal rods with a defect at its centre, in which a frequency selectivity is similarly demonstrated. Because of its unique electromagnetic property, the cavity has many promising applications in active and passive devices operating in the millimetre, sub-millimetre, and even THz wave range. As a specific application, the feasibility of substituting the traditional cylindrical resonant cavity loaded in a gyrotron for a dielectric PBGC to achieve a transverse high-order operation is discussed under the consideration of the electromagnetic features of the cavity. The study shows the great potential value of such a cavity for gyrotron devices.

EPR and DNP Properties of Certain Novel Single Electron Contrast Agents Intended for Oximetric Imaging

DEFF Research Database (Denmark)

Ardenkjær-Larsen, J. H.; Laursen, I; Leunbach, I.

1998-01-01

Parameters of relevance to oximetry with Overhauser magnetic resonance imaging (OMRI) have been measured for three single electron contrast agents of the triphenylmethyl type. The single electron contrast agents are stable and water soluble. Magnetic resonance properties of the agents have been...... examined with electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), and dynamic nuclear polarization (DNP) at 9.5 mT in water, isotonic saline, plasma, and blood at 23 and 37°C. The relaxivities of the agents are about 0.2–0.4 mM−1s−1and the DNP enhancements extrapolate close...... to the dipolar limit. The agents have a single, narrow EPR line, which is analyzed as a Voigt function. The linewidth is measured as a function of the agent concentration and the oxygen concentration. The concentration broadenings are about 1–3 μT/mM and the Lorentzian linewidths at infinite dilution are less...

Improved Design of Beam Tunnel for 42 GHz Gyrotron

Science.gov (United States)

Singh, Udaybir; Kumar, Nitin; Purohit, L. P.; Sinha, A. K.

2011-04-01

In gyrotron, there is the chance of generation and excitation of unwanted RF modes (parasite oscillations). These modes may interact with electron beam and consequently degrade the beam quality. This paper presents the improved design of the beam tunnel to reduce the parasite oscillations and the effect of beam tunnel geometry on the electron beam parameters. The design optimization of the beam tunnel has been done with the help of 3-D simulation software CST-Microwave Studio and the effect of beam tunnel geometry on the electron beam parameters has been analyzed by EGUN code.

Nonlinearly driven oscillations in the gyrotron traveling-wave amplifier

International Nuclear Information System (INIS)

Chiu, C. C.; Pao, K. F.; Yan, Y. C.; Chu, K. R.; Barnett, L. R.; Luhmann, N. C. Jr.

2008-01-01

By delivering unprecedented power and gain, the gyrotron traveling-wave amplifier (gyro-TWT) offers great promise for advanced millimeter wave radars. However, the underlying physics of this complex nonlinear system is yet to be fully elucidated. Here, we report a new phenomenon in the form of nonlinearly driven oscillations. A zero-drive stable gyro-TWT is shown to be susceptible to a considerably reduced dynamic range at the band edge, followed by a sudden transition into driven oscillations and then a hysteresis effect. An analysis of this unexpected behavior and its physical interpretation are presented.

A high-order particle-in-cell method for low density plasma flow and the simulation of gyrotron resonator devices

International Nuclear Information System (INIS)

Stock, Andreas

2013-01-01

Within this thesis a parallelized, transient, three-dimensional, high-order discontinuous Galerkin Particle-in-Cell solver is developed and used to simulate the resonant cavity of a gyrotron. The high-order discontinuous Galerkin approach - a Finite-Element type method - provides a fast and efficient algorithm to numerically solve Maxwell's equations used within this thesis. Besides its outstanding dissipation and dispersion properties, the discontinuous Galerkin approach easily allows for using unstructured grids, as required to simulate complex-shaped engineering devices. The discontinuous Galerkin approach approximates a wavelength with significantly less degrees of freedom compared to other methods, e.g. Finite Difference methods. Furthermore, the parallelization capabilities of the discontinuous Galerkin framework are excellent due to the very local dependencies between the elements. These properties are essential for the efficient numerical treatment of the Vlasov-Maxwell system with the Particle-in-Cell method. This system describes the self-consistent interaction of charged particles and the electromagnetic field. As central application within this thesis gyrotron resonators are simulated with the discontinuous Galerkin Particle-in-Cell method on high-performance-computers. The gyrotron is a high-power millimeter wave source, used for the electron cyclotron resonance heating of magnetically confined fusion plasma, e.g. in the Wendelstein 7-X experimental fusion-reactor. Compared to state-of-the-art simulation tools used for the design of gyrotron resonators the Particle-in-Cell method does not use any significant physically simplifications w.r.t. the modelling of the particle-field-interaction, the geometry and the wave-spectrum. Hence, it is the method of choice for validation of current simulation tools being restricted by these simplifications. So far, the Particle-in-Cell method was restricted to be used for demonstration calculations only, because

A high-order particle-in-cell method for low density plasma flow and the simulation of gyrotron resonator devices

Energy Technology Data Exchange (ETDEWEB)

Stock, Andreas

2013-04-26

Within this thesis a parallelized, transient, three-dimensional, high-order discontinuous Galerkin Particle-in-Cell solver is developed and used to simulate the resonant cavity of a gyrotron. The high-order discontinuous Galerkin approach - a Finite-Element type method - provides a fast and efficient algorithm to numerically solve Maxwell's equations used within this thesis. Besides its outstanding dissipation and dispersion properties, the discontinuous Galerkin approach easily allows for using unstructured grids, as required to simulate complex-shaped engineering devices. The discontinuous Galerkin approach approximates a wavelength with significantly less degrees of freedom compared to other methods, e.g. Finite Difference methods. Furthermore, the parallelization capabilities of the discontinuous Galerkin framework are excellent due to the very local dependencies between the elements. These properties are essential for the efficient numerical treatment of the Vlasov-Maxwell system with the Particle-in-Cell method. This system describes the self-consistent interaction of charged particles and the electromagnetic field. As central application within this thesis gyrotron resonators are simulated with the discontinuous Galerkin Particle-in-Cell method on high-performance-computers. The gyrotron is a high-power millimeter wave source, used for the electron cyclotron resonance heating of magnetically confined fusion plasma, e.g. in the Wendelstein 7-X experimental fusion-reactor. Compared to state-of-the-art simulation tools used for the design of gyrotron resonators the Particle-in-Cell method does not use any significant physically simplifications w.r.t. the modelling of the particle-field-interaction, the geometry and the wave-spectrum. Hence, it is the method of choice for validation of current simulation tools being restricted by these simplifications. So far, the Particle-in-Cell method was restricted to be used for demonstration calculations only, because

Velocity-space tomography of fusion plasmas by collective Thomson scattering of gyrotron radiation

DEFF Research Database (Denmark)

Salewski, Mirko; Jacobsen, A.S.; Jensen, Thomas

2016-01-01

-tonoise ratio becomes fairly low for MeV-range ions. Ions at any energy can be detected well by collective Thomson scattering of mm-wave radiation from a high-power gyrotron. We demonstrate how collective Thomson scattering can be used to measure 푓2퐷푣 in the MeV-range in reactor relevant plasmas...

dNP2-ctCTLA-4 inhibits German cockroach extract-induced allergic airway inflammation and hyper-responsiveness via inhibition of Th2 responses.

Science.gov (United States)

Lim, Sangho; Ho Sohn, Jung; Koo, Ja-Hyun; Park, Jung-Won; Choi, Je-Min

2017-08-04

German cockroaches are major household allergens that can trigger allergic airway inflammatory diseases with sensitive T-cell responses. Although the use of immune modulatory biologics, such as antibodies, to mediate allergic responses has recently been examined, only systemic administration is available because of the size limitations on intranasal administration. Here we utilized a cell-permeable peptide, dNP2, to deliver the cytoplasmic domain of cytotoxic T-lymphocyte antigen-4 (ctCTLA-4) through the airway epithelium to modulate Th2 responses in a German cockroach extract (GCE)-induced allergic airway inflammation model. The intranasal delivery efficiency of the dNP2-dTomato protein to the lungs was higher in GCE-induced asthmatic lung parenchymal cells compared to the sham cells. Intranasal administration of the dNP2-ctCTLA-4 protein inhibited airway hyper-responsiveness and reduced airway inflammation and remodeling, including goblet cell metaplasia and collagen deposition around the bronchi. The number of infiltrated cells, including eosinophils, and the levels of IL-4, IL-5, IL-13 and IFN-γ in the lungs were significantly reduced, presumably owing to inhibition of Th2 differentiation. However, intranasal administration of CTLA4-Ig did not inhibit airway inflammation. These results collectively suggest that dNP2-ctCTLA-4 is an efficient intranasally applicable candidate biologic for treating allergic asthma.

Circuit design and simulation of a HV-supply controlling the power of 140 GHz 1 MW gyrotrons for ECRH on W7-X

International Nuclear Information System (INIS)

Brand, P.; Mueller, G.A.

2003-01-01

For plasma heating by ECR in the Stellarator W7-X under construction, 140 GHz gyrotrons with 1 MW cw output power are under development. These tubes have a voltage depressed collector for electron energy recovery. Each gyrotron is fed by two high-voltage sources: a high-power supply for driving the electron beam and a precision low-power supply for beam acceleration. In addition, a protection system with a thyratron crowbar for fast power removal in case of gyrotron arcing is installed. The low-power high-voltage source for beam acceleration is realized by a high-voltage servo-amplifier driving the depression voltage such that the influence of the voltage noise of the main high-power supply on the acceleration voltage is suppressed by feed-back control of the amplifier. Design and simulation of the servo-amplifier by PSpice is presented

Effect of ion compensation of the beam space charge on gyrotron operation

Energy Technology Data Exchange (ETDEWEB)

Fokin, A. P.; Glyavin, M. Yu. [Institute of Applied Physics, Russian Academy of Sciences, Nizhny Novgorod 603950 (Russian Federation); Nusinovich, G. S. [Institute for Research in Electronics and Applied Physics, University of Maryland, College Park, Maryland 20742-3511 (United States)

2015-04-15

In gyrotrons, the coherent radiation of electromagnetic waves takes place when the cyclotron resonance condition between the wave frequency and the electron cyclotron frequency or its harmonic holds. The voltage depression caused by the beam space charge field changes the relativistic cyclotron frequency and, hence, can play an important role in the beam-wave interaction process. In long pulse and continuous-wave regimes, the beam space charge field can be partially compensated by the ions, which appear due to the beam impact ionization of neutral molecules of residual gases in the interaction space. In the present paper, the role of this ion compensation of the beam space charge on the interaction efficiency is analyzed. We also analyze the effect of the electron velocity spread on the limiting currents and discuss some effects restricting the ion-to-beam electron density ratio in the saturation stage. It is shown that the effect of the ion compensation on the voltage depression caused by the beam space charge field can cause significant changes in the efficiency of gyrotron operation and, in some cases, even result in the break of oscillations.

Design and simulation of a {approx}390 GHz seventh harmonic gyrotron using a large orbit electron beam

Energy Technology Data Exchange (ETDEWEB)

Li Fengping; He Wenlong; Cross, Adrian W; Donaldson, Craig R; Zhang Liang; Phelps, Alan D R; Ronald, Kevin, E-mail: Fengping.li@strath.ac.u [SUPA, Department of Physics, University of Strathclyde, Glasgow, G4 0NG (United Kingdom)

2010-04-21

A {approx}390 GHz harmonic gyrotron based on a cusp electron gun has been designed and numerically modelled. The gyrotron operates at the seventh harmonic of the electron cyclotron frequency with the beam interacting with a TE{sub 71} waveguide mode. Theoretical as well as numerical simulation results using the 3D particle-in-cell code MAGIC are presented. The cusp gun generated an axis-encircling, annular shaped electron beam of energy 40 keV, current 1.5 A with a velocity ratio {alpha} of 3. Smooth cylindrical waveguides have been studied as the interaction cavities and their cavity Q optimized for 390 GHz operation. In the simulations {approx}600 W of output power at the design frequency has been demonstrated.

RF Behavior of Cylindrical Cavity Based 240 GHz, 1 MW Gyrotron for Future Tokamak System

Science.gov (United States)

Kumar, Nitin; Singh, Udaybir; Bera, Anirban; Sinha, A. K.

2017-11-01

In this paper, we present the RF behavior of conventional cylindrical interaction cavity for 240 GHz, 1 MW gyrotron for futuristic plasma fusion reactors. Very high-order TE mode is searched for this gyrotron to minimize the Ohmic wall loading at the interaction cavity. The mode selection process is carried out rigorously to analyze the mode competition and design feasibility. The cold cavity analysis and beam-wave interaction computation are carried out to finalize the cavity design. The detail parametric analyses for interaction cavity are performed in terms of mode stability, interaction efficiency and frequency. In addition, the design of triode type magnetron injection gun is also discussed. The electron beam parameters such as velocity ratio and velocity spread are optimized as per the requirement at interaction cavity. The design studies presented here confirm the realization of CW, 1 MW power at 240 GHz frequency at TE46,17 mode.

Experimental results for a 1.5 MW, 110 GHz gyrotron oscillator with reduced mode competition

Science.gov (United States)

Choi, E. M.; Marchewka, C. D.; Mastovsky, I.; Sirigiri, J. R.; Shapiro, M. A.; Temkin, R. J.

2006-02-01

A new result from a 110GHz gyrotron at MIT is reported with an output power of 1.67MW and an efficiency of 42% when operated at 97kV and 41A for 3μs pulses in the TE22,6 mode. These results are a major improvement over results obtained with an earlier cavity design, which produced 1.43MW of power at 37% efficiency. These new results were obtained using a cavity with a reduced output taper angle and a lower ohmic loss when compared with the earlier cavity. The improved operation is shown experimentally to be the result of reduced mode competition from the nearby TE19,7 mode. The reduced mode competition agrees well with an analysis of the startup scenario based on starting current simulations. The present results should prove useful in planning long pulse and CW versions of the 110GHz gyrotron.

Experimental results for a 1.5 MW, 110 GHz gyrotron oscillator with reduced mode competition

International Nuclear Information System (INIS)

Choi, E.M.; Marchewka, C.D.; Mastovsky, I.; Sirigiri, J.R.; Shapiro, M.A.; Temkin, R.J.

2006-01-01

A new result from a 110 GHz gyrotron at MIT is reported with an output power of 1.67 MW and an efficiency of 42% when operated at 97 kV and 41 A for 3 μs pulses in the TE 22,6 mode. These results are a major improvement over results obtained with an earlier cavity design, which produced 1.43 MW of power at 37% efficiency. These new results were obtained using a cavity with a reduced output taper angle and a lower ohmic loss when compared with the earlier cavity. The improved operation is shown experimentally to be the result of reduced mode competition from the nearby TE 19,7 mode. The reduced mode competition agrees well with an analysis of the startup scenario based on starting current simulations. The present results should prove useful in planning long pulse and CW versions of the 110 GHz gyrotron

Modeling DNP3 Traffic Characteristics of Field Devices in SCADA Systems of the Smart Grid

Energy Technology Data Exchange (ETDEWEB)

Yang, Huan [Lehigh Univ., Bethlehem, PA (United States); Cheng, Liang [Lehigh Univ., Bethlehem, PA (United States); Chuah, Mooi Choo [Lehigh Univ., Bethlehem, PA (United States)

2017-03-08

In the generation, transmission, and distribution sectors of the smart grid, intelligence of field devices is realized by programmable logic controllers (PLCs). Many smart-grid subsystems are essentially cyber-physical energy systems (CPES): For instance, the power system process (i.e., the physical part) within a substation is monitored and controlled by a SCADA network with hosts running miscellaneous applications (i.e., the cyber part). To study the interactions between the cyber and physical components of a CPES, several co-simulation platforms have been proposed. However, the network simulators/emulators of these platforms do not include a detailed traffic model that takes into account the impacts of the execution model of PLCs on traffic characteristics. As a result, network traces generated by co-simulation only reveal the impacts of the physical process on the contents of the traffic generated by SCADA hosts, whereas the distinction between PLCs and computing nodes (e.g., a hardened computer running a process visualization application) has been overlooked. To generate realistic network traces using co-simulation for the design and evaluation of applications relying on accurate traffic profiles, it is necessary to establish a traffic model for PLCs. In this work, we propose a parameterized model for PLCs that can be incorporated into existing co-simulation platforms. We focus on the DNP3 subsystem of slave PLCs, which automates the processing of packets from the DNP3 master. To validate our approach, we extract model parameters from both the configuration and network traces of real PLCs. Simulated network traces are generated and compared against those from PLCs. Our evaluation shows that our proposed model captures the essential traffic characteristics of DNP3 slave PLCs, which can be used to extend existing co-simulation platforms and gain further insights into the behaviors of CPES.

30 kV/10 mA solid state anode modulator for gyrotron plasma heating: design issues and results

International Nuclear Information System (INIS)

Fasel, D.; Lucia, C.; Ganuza, D.; Doyharzabal, I.

2001-01-01

Three 30 kV/10 mA solid state pulsed modulators have been delivered to the CRPP in Lausanne, by the company JEMA. Each modulator supplies the anode grid of a triode type gyrotron, used for heating purpose at the third harmonic in the TCV Tokamak. The main parameters of the final design are: the use of solid state technology, a floating output referred to the -80 kV of the gyrotron cathode potential, an output voltage range of -5 to 30 kV, 1 kHz square and sinusoidal modulation, fast switching off to -5 kV (10 μs) and pulsed operation (duty cycle of 1%). After studying and testing a solution based on regulated Mosfet transistors in series, a more stable alternative has been adopted. The final topology consists of a rectifier fed from an insulated 230 V input, a chopper, two inverter steps (for +30 and -5 kV) supplying two diode rectifiers bridges through HV transformers with two switches which commute the load to the positive or negative voltage, connected in series. This article presents the most significant aspects of the design, with special emphasis on the control principle. The final results will be presented in the context of normal operation, supplying a triode gyrotron

Development of 1 MW gyrotron and progress of ECH system for the GAMMA 10 tandem mirror in Tsukuba

International Nuclear Information System (INIS)

Imai, T.; Kariya, T.; Minami, R.; Shidara, H.; Endo, Y.; Harigae, M.; Nakamura, M.; Sakagoshi, Y.; Murofushi, N.; Ichimura, M.; Nakashima, Y.; Yoshikawa, M.; Yamaguchi, Y.; Sakamoto, Keishi; Kubo, S.; Shimozuma, T.; Mutoh, T.; Takahashi, H.; Mitsunaka, Y.

2008-10-01

High power gyrotrons with TE 4,2 cavity at 28 GHz and with TE 18,6 cavity and a diamond window at 77 GHz have been developed for GAMMA 10 and LHD in the joint program of NIFS and University of Tsukuba. The maximum outputs of 570 kW at 28 GHz and 1.1 MW at 77 GHz were obtained corresponding to each design. The operations of more than 750 kW for 5 sec. and 810 kW for 3.5 sec. were achieved in the developing tubes at 77 GHz, which is the first high power-long pulse result of the 77 GHz tube. The experimental simulation of the effect of the stray RF in the 28 GHz tube indicates the stray RF is the one of the major causes limiting gyrotron performance. The output of more than 1 MW with 40% oscillation efficiency is expected from the design of the next 28 GHz gyrotron for GAMMA 10. Installation of the polarizer in the transmission line enhanced the performance of the ECH system in GAMMA 10, that is the first result which clearly showed ∼100% X mode excitation is a key to design the efficient fundamental ECH system of strong field side injection in mirror devices. (author)

Effects of DNP on the cell surface properties of marine bacteria and its implication for adhesion to surfaces

Digital Repository Service at National Institute of Oceanography (India)

Jain, A.; Nishad, K.K.; Bhosle, N.B.

The effect of 2, 4-dinitrophenol (DNP) on extracelluar polysaccharides (EPS), cell surface charge, and hydrophobicity of six marine bacterial cultures was studied, and its influence on attachment of these bacteria to glass and polystyrene...

Advances in High Power Calorimetric Matched Loads for Short Pulses and CW Gyrotrons

International Nuclear Information System (INIS)

Bin, W.M.; Bruschi, A.; Cirant, S.; Gandini, F.; Granucci, G.; Mellera, V.; Muzzini, V.; Nardone, A.; Sozzi, C.; Spinicchia, N.

2006-01-01

The development of high power gyrotrons for plasma physics research needs proper matched and calorimetric loads able to absorb and measure the power, which nowadays is foreseen to be as high as 2 MW during CW operations. To this end IFP/CNR has developed a family of matched loads useful in the mm-wave frequency band for applications ranging from a few ms to CW in pulse length. The different loads in the family, made of an integrating sphere with a partially reflecting coating on the inner wall, are characterized by having the same absorbing geometry for the incoming beam and a different heat removal system for the specific application. Some important advances have been recently achieved from the point of view of the uniformity of power distribution on the absorbing wall and of the load construction. With high precision achieved in the coating thickness a better control of the heating power distribution is possible by proper shaping of the local reflectivity, in addition to the shaping of the mirror dispersing the input beam. A more sophisticated model describing the power distribution has been developed, taking into account a variable thickness of the absorbing coating, the proper shape of the spreading mirror, the frequency of the incoming radiation and the shape of the input beam. Lower coating thickness is shown to be preferable, at equal local reflectivity, from the point of view of a lower peak temperature and thermal stress. The paper describes a load with variable coating thickness along the meridian of the sphere, showing a uniform power deposition on the inner walls. The cooling pipe is completely electroformed on the spherical copper shell, ensuring the maintenance of the correct curvature of the inner surface and a fast heat conduction from the absorbing coating to the water through the thin copper body. For CW use all heated parts of the load must be cooled and this is achieved by 16 electroformed spiral channels. Both short pulse loads (0.1-1 s) and

Development program for a 200 kW, cw gyrotron. Quarterly report No. 11, January-March 1982

International Nuclear Information System (INIS)

Tancredi, J.J.; Caplan, M.; Sandoval, J.J.; Matranga, V.A.

1982-01-01

The objective of this program is the design and development of a millimeter wave device to produce 200 kW of continuous-wave power at 60 GHz. The device, a gyrotron oscillator, will be compatible with power delivery to an electron-cyclotron plasma. Smooth control of RF power output over a 17 dB range is required, and the device should be capable of operation into a severe time-varying load mismatch. During this report period, the beam instability problem which plagued S/N 1 testing was evaluated in more detail. Separate tests were conducted on the gun tester and the lossy drift section, as well as both of these combined, and the results were compared to gyrotron tests on S/N 1. The instability problem now appears to be associated with RF leakage from the cavity

Effects of INH, DNP, 2,4-D and CMU on the photosynthetic activity of barley and maize plants; Efecto de cuatro inhibidores metabolicos (INH, DNP, 2, 4-D y CMU) sobre la actividad fotosintetica de plantular de cebada (Hordeum vulgare L.) y Maiz (Zea mais L.)

Energy Technology Data Exchange (ETDEWEB)

Fernandez, J; Prieto, M P

1979-07-01

Determinations of the rate of photosynthesis were made in barley and maize leaves treated with INH, DNP, 2,4-D or CMU. 1 ppm of the chemicals in nutritive solutions was absorbed by roots during 24 or 48 hours in both dark and light conditions. After this period, photosynthetic activity, compensation point and 14{sup C}O{sub 2} assimilation were determined. Results show that INH increases the rate of photosynthesis, DNP and 2,4-D do not alter it sensibly and CMU acts as a strong inhibitor of photosynthesis. Some possible applications for ths obtention of labelled compounds by biosynthesis are discussed. (Author) 87 refs.

Operation of a quasi-optical gyrotron with a gaussian output coupler

Energy Technology Data Exchange (ETDEWEB)

Hogge, J.P.; Tran, T.M.; Paris, P.J.; Tran, M.Q. [Ecole Polytechnique Federale, Lausanne (Switzerland). Centre de Recherche en Physique des Plasma (CRPP)

1996-03-01

The operation of a 92 GHz quasi-optical gyrotron (QOG) having a resonator formed by a spherical mirror and a diffraction grating placed in -1 order Littrow mount is presented. A power of 150 kW with a gaussian output pattern was measured. The gaussian content in the output was 98% with less than 1% of depolarization. By optimizing the magnetic field at fixed frequency, a maximum efficiency of 15% was reached. (author) 12 figs., 2 tabs., 22 refs.

Numerical Simulation of a Double-anode Magnetron Injection Gun for 110 GHz, 1 MW Gyrotron

Science.gov (United States)

Singh, Udaybir; Kumar, Nitin; Purohit, L. P.; Sinha, Ashok K.

2010-07-01

A 40 A double-anode magnetron injection gun for a 1 MW, 110 GHz gyrotron has been designed. The preliminary design has been obtained by using some trade-off equations. The electron beam analysis has been performed by using the commercially available code EGUN and the in-house developed code MIGANS. The operating mode of the gyrotron is TE22,6 and it is operated in the fundamental harmonic. The electron beam with a low transverse velocity spread ( δ {β_{ bot max }} = 2.26% ) and the transverse-to-axial velocity ratio of the electron beam (α) = 1.37 is obtained. The simulated results of the MIG obtained with the EGUN code have been validated with another trajectory code TRAK. The results on the design output parameters obtained by both the codes are in good agreement. The sensitivity analysis has been carried out by changing the different gun parameters to decide the fabrication tolerance.

Development of over-1 MW gyrotrons for the LHD and the GAMMA 10 ECH systems

International Nuclear Information System (INIS)

Imai, T.; Kariya, T.; Minami, R.

2010-11-01

For the ECH upgrade program of LHD and GAMMA10, over-1 MW power gyrotrons have been developed in the joint program of NIFS and University of Tsukuba. The gyrotrons for LHD and GAMMA 10 have TE 18,6 cavity and a diamond window at 77 GHz, and with TE 8,3 cavity at 28 GHz, respectively. The maximum outputs obtained are 1.9 MW for 0.1 s on the 77 GHz LHD tube and ∼ 1 MW on the 28 GHz one, which are the new records in these frequency ranges. The results of 1.8 MW for 1 s, 1.6 MW for 1.8s, 1 MW for 5 s, 300 kW for 40 min and 200 kW for 75 min were achieved at 77 GHz. In the long pulse operation, it is found that the stray RF is the major cause limiting the pulse length. Design improvements of the diffraction loss, the cavity and pitch factor α (=v sub(perpendicular)/v sub(parallel)) dispersion of the MIG have made the 77 GHz tube performance better, which have enabled to demonstrate 1.9 MW output and long pulse operation for more than 1 hour with 200 kW. The three 77 GHz gyrotrons have already been installed in the LHD ECH system and more than 3 MW has been injected into LHD plasma. In the 28 GHz long pulse operation, 400 kW for 1 sec has been obtained and it is found the higher and longer pulse operation would be possible with the operation optimization and conditioning. (author)

The gyrotron - a natural source of high-power orbital angular momentum millimeter-wave beams

Science.gov (United States)

Thumm, M.; Sawant, A.; Choe, M. S.; Choi, E. M.

2017-08-01

Orbital angular momentum (OAM) of electromagnetic-wave beams provides further diversity to multiplexing in wireless communication. The present report shows that higher-order mode gyrotrons are natural sources of high-power OAM millimeter (mm) wave beams. The well-defined OAM of their rotating cavity modes operating at near cutoff frequency has been derived by photonic and electromagnetic wave approaches.

Microwave generation for magnetic fusion energy applications: Task A -- Experimental and numerical study of microwave sources for ECRH incorporating depressed collectors and with ITER-relevant parameters, and Task B -- Theory and modeling of high frequency, high power gyrotron operation. Final report, July 15, 1994--July 14, 1995

International Nuclear Information System (INIS)

1995-01-01

A proof-of-principle short pulse (∼ 100 ns) experiment has successfully demonstrated operation of a sheet-beam FEL amplifier with output power of 250 kW at 86 Ghz and with 24 dB saturated gain and ∼ 3% efficiency. Gain in the linear region was 30 dB. Measured performance parameters were in good agreement with predictions of a multi-mode, time dependence code. Also, a code has been developed to design depressed collectors which will enhance efficiency of ECRH sources (both FELs and gyrotrons). Extensive analytical and theoretical work in support of high power gyrotron development at Varian and MIT, and in support of ITER has been carried out. Specific studies are described. The effect of beam quality on the operation of the 145 GHz gyrotrons at MIT has been characterized using experimentally measured beam velocity distribution functions. The observed performance of these devices is consistent with a 10% RMS perpendicular velocity spread. An extensive study of mode competition in the 110 GHZ experiments at Varian and MIT has been carried out. Design criteria for the suppression of parasitic modes have been given for these experiments. The issues of mode competition and beam quality in the proposed 170 GHz megawatt gyrotrons for ITER have been investigated. Designs of cavities which eliminate unwanted modes have been made, and their sensitivity to beam quality studied. The constraints of lower power density and absence of mode competition coupled with the anticipated beam quality restrict efficiency. Efficiency can be improved by increasing the power density in the wall, improving beam quality, or perhaps by using a more advanced cavity. Studies of the causes of velocity spread in MIG guns have been initiated. Further, the effect of beam cavity misalignment on mode competition has been addressed

Control of the Superconducting Magnets current Power Supplies of the TJ-II Gyrotrons; Control de las Fuentes de Corriente de las Bobinas Superconductoras de los Girotrones del TJ-II

Energy Technology Data Exchange (ETDEWEB)

Ros, A; Fernandez, A; Tolkachev, A; Catalan, G

2006-07-01

The TJ-II ECRH heating system consists of two gyrotrons, which can deliver a maximum power of 300 kW at a frequency of 53.2 GHz. Another 28 GHz gyrotron is going to be used in the Bernstein waves heating system. In order to get the required frequency, the gyrotrons need and homogeneous magnetic field of several tesla, which is generated by a superconducting coil field by a current source. This document describes the current source control as well as the high precision ammeters control. These ammeters measure the current in the superconducting coils. The user interface and the programming of the control system are described. The communication between devices is also explained. (author) 9 Refs.

Study of a high-order-mode gyrotron traveling-wave amplifier

International Nuclear Information System (INIS)

Chiu, C. C.; Tsai, C. Y.; Kao, S. H.; Chu, K. R.; Barnett, L. R.; Luhmann, N. C. Jr.

2010-01-01

Physics and performance issues of a TE 01 -mode gyrotron traveling-wave amplifier are studied in theory. For a high order mode, absolute instabilities on neighboring modes at the fundamental and higher cyclotron harmonic frequencies impose severe constraints to the device capability. Methods for their stabilization are outlined, on the basis of which the performance characteristics are examined in a multidimensional parameter space under the marginal stability criterion. The results demonstrate the viability of a high-order-mode traveling-wave amplifier and provide a roadmap for design tradeoffs among power, bandwidth, and efficiency. General trends are observed and illustrated with specific examples.

Design of 28 GHz, 200 kW Gyrotron for ECRH Applications

Science.gov (United States)

Yadav, Vivek; Singh, Udaybir; Kumar, Nitin; Kumar, Anil; Deorani, S. C.; Sinha, A. K.

2013-01-01

This paper presents the design of 28 GHz, 200 kW gyrotron for Indian TOKAMAK system. The paper reports the designs of interaction cavity, magnetron injection gun and RF window. EGUN code is used for the optimization of electron gun parameters. TE03 mode is selected as the operating mode by using the in-house developed code GCOMS. The simulation and optimization of the cavity parameters are carried out by using the Particle-in-cell, three dimensional (3-D)-electromagnetic simulation code MAGIC. The output power more than 250 kW is achieved.

Advantages of using gyrotron scattering for alpha particle diagnostics

International Nuclear Information System (INIS)

Woskoboinikow, P.P.; Cohn, D.R.; Machuzak, J.S.; Myer, R.C.; Rhee, R.Y.

1987-07-01

Millimeter-wave gyrotron collective Thomson scattering can be an effective diagnostic technique for the study of alpha particle behavior in ignited plasmas. The measurement of alpha particle density, velocity distribution, and alpha particle induced plasma instabilities can be accomplished with both spatial and temporal resolution. Advantages include long pulse operation which can make possible very high signal to noise ratios and use of millimeter waves which maximizes the Doppler shifted scattered signal in WHz -1 and makes possible scattering angles up to 180 0 . Extraordinary mode scattering at approximately 60 and 200 GHz would be used in TFTR and CIT respectively, and 140 GHz ordinary mode scattering in JET. 8 refs., 1 fig

Advanced Output Coupling for High Power Gyrotrons

Energy Technology Data Exchange (ETDEWEB)

Read, Michael [Calabazas Creek Research, Inc., San Mateo, CA (United States); Ives, Robert Lawrence [Calabazas Creek Research, Inc., San Mateo, CA (United States); Marsden, David [Calabazas Creek Research, Inc., San Mateo, CA (United States); Collins, George [Calabazas Creek Research, Inc., San Mateo, CA (United States); Temkin, Richard [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Guss, William [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Lohr, John [General Atomics, La Jolla, CA (United States); Neilson, Jeffrey [Lexam Research, Redwood City, CA (United States); Bui, Thuc [Calabazas Creek Research, Inc., San Mateo, CA (United States)

2016-11-28

The Phase II program developed an internal RF coupler that transforms the whispering gallery RF mode produced in gyrotron cavities to an HE11 waveguide mode propagating in corrugated waveguide. This power is extracted from the vacuum using a broadband, chemical vapor deposited (CVD) diamond, Brewster angle window capable of transmitting more than 1.5 MW CW of RF power over a broad range of frequencies. This coupling system eliminates the Mirror Optical Units now required to externally couple Gaussian output power into corrugated waveguide, significantly reducing system cost and increasing efficiency. The program simulated the performance using a broad range of advanced computer codes to optimize the design. Both a direct coupler and Brewster angle window were built and tested at low and high power. Test results confirmed the performance of both devices and demonstrated they are capable of achieving the required performance for scientific, defense, industrial, and medical applications.

Development program for a 200-kW, c-w gyrotron. Quarterly report No. 7, January-March 1981

International Nuclear Information System (INIS)

Tancredi, J.J.; Caplan, M.; Sandoval, J.J.; Jordan, E.; Matranga, V.A.

1981-01-01

The objective of this program is the design and development of a millimeter-wave device to produce 200 kW of continuous-wave power at 60 GHz. The device, which will be a gyrotron oscillator, will be compatible with power delivery to an electron-cyclotron plasma. Smooth control of rf power output over a 17 dB range is required, and the device should be capable of operation into a severe time-varying rf load mismatch. An interim program goal is to demonstrate operation at 100 ms pulse widths by 31 December 1981. During this quarter, progress was made in the areas of tube, solenoid, and facility construction. Two magnetron injection gun assemblies were completed, and one was partially evaluated as a gun tester. The superconducting solenoid was assembled, but a vacuum leak prevented early delivery in March. Construction began on the gyrotron test facility by enclosing the area and providing bake-out and vacuum processing utilities

Demonstration of a High-Order Mode Input Coupler for a 220-GHz Confocal Gyrotron Traveling Wave Tube

Science.gov (United States)

Guan, Xiaotong; Fu, Wenjie; Yan, Yang

2018-02-01

A design of high-order mode input coupler for 220-GHz confocal gyrotron travelling wave tube is proposed, simulated, and demonstrated by experimental tests. This input coupler is designed to excite confocal TE 06 mode from rectangle waveguide TE 10 mode over a broadband frequency range. Simulation results predict that the optimized conversion loss is about 2.72 dB with a mode purity excess of 99%. Considering of the gyrotron interaction theory, an effective bandwidth of 5 GHz is obtained, in which the beam-wave coupling efficiency is higher than half of maximum. The field pattern under low power demonstrates that TE 06 mode is successfully excited in confocal waveguide at 220 GHz. Cold test results from the vector network analyzer perform good agreements with simulation results. Both simulation and experimental results illustrate that the reflection at input port S11 is sensitive to the perpendicular separation of two mirrors. It provides an engineering possibility for estimating the assembly precision.

Development and contribution of rf heating and current drive systems to long pulse, high performance experiments in JT-60U

International Nuclear Information System (INIS)

Moriyama, Shinichi; Seki, Masami; Terakado, Masayuki; Shimono, Mitsugu; Ide, Shunsuke; Isayama, Akihiko; Suzuki, Takahiro; Fujii, Tsuneyuki

2005-01-01

To contribute to high performance long pulse (∼65 s) experiments in JT-60U, the target of the electron cyclotron (EC) operation in long pulse is 0.6 MW for 30 s with four gyrotrons, though 10 MJ (2.8 MW and 3.6 s) was achieved in high power operation before 2003. One of the critical issues for the long pulse operation is detuning due to decay in beam current of the gyrotron. This decay comes from the cathode cooling by continuous electron emission. As a countermeasure for this issue, active adjustments for the heater current and anode voltage during the pulse have successfully extended the duration of a good oscillation condition for the gyrotron. As a result, 0.4 MW for 16 s with one gyrotron to the dummy load and for 8.7 s to the plasma have been achieved up to now

Quasi-optical converters for high-power gyrotrons: a brief review of physical models, numerical methods and computer codes

International Nuclear Information System (INIS)

Sabchevski, S; Zhelyazkov, I; Benova, E; Atanassov, V; Dankov, P; Thumm, M; Arnold, A; Jin, J; Rzesnicki, T

2006-01-01

Quasi-optical (QO) mode converters are used to transform electromagnetic waves of complex structure and polarization generated in gyrotron cavities into a linearly polarized, Gaussian-like beam suitable for transmission. The efficiency of this conversion as well as the maintenance of low level of diffraction losses are crucial for the implementation of powerful gyrotrons as radiation sources for electron-cyclotron-resonance heating of fusion plasmas. The use of adequate physical models, efficient numerical schemes and up-to-date computer codes may provide the high accuracy necessary for the design and analysis of these devices. In this review, we briefly sketch the most commonly used QO converters, the mathematical base they have been treated on and the basic features of the numerical schemes used. Further on, we discuss the applicability of several commercially available and free software packages, their advantages and drawbacks, for solving QO related problems

Design of 84 Ghz, 500 kW gyrotron for ECRH application

International Nuclear Information System (INIS)

Singh, Udaybir; Nitin Kumar; Anil Kumar; Rao, R.R.; Sinha, A.K.

2013-01-01

The design and numerical simulation of the 84 GHz gyrotron, are performed for first harmonic operation. TE 10,4 is selected as the operating mode after the rigorous analysis of several TE modes. Then the interaction cavity geometrical parameters are optimized on the basis of cold cavity simulations and Q factor calculation. The electron beam parameters are optimized in the beam-wave interaction simulations using Particle-in-Cell (PIC) code MAGIC. The triode-type magnetron injection gun with the accelerating voltage 70 kV, the beam current 10 A and the maximum transverse velocity spread less than 5% is designed. (author)

Measurement of 14N quadrupole couplings in biomolecular solids using indirect-detection 14N solid-state NMR with DNP.

Science.gov (United States)

Jarvis, J A; Haies, I; Lelli, M; Rossini, A J; Kuprov, I; Carravetta, M; Williamson, P T F

2017-11-07

The quadrupolar interaction experienced by the spin-1 14 N nucleus is known to be extremely sensitive to local structure and dynamics. Furthermore, the 14 N isotope is 99.6% naturally abundant, making it an attractive target for characterisation of nitrogen-rich biological molecules by solid-state NMR. In this study, dynamic nuclear polarization (DNP) is used in conjunction with indirect 14 N detected solid-state NMR experiments to simultaneously characterise the quadrupolar interaction at multiple 14 N sites in the backbone of the microcrystalline protein, GB3. Considerable variation in the quadrupolar interaction (>700 kHz) is observed throughout the protein backbone. The distribution in quadrupolar interactions observed reports on the variation in local backbone conformation and subtle differences in hydrogen-bonding; demonstrating a new route to the structural and dynamic analysis of biomolecules.

Tunable driver for the LLNL FEL experiment

International Nuclear Information System (INIS)

Guss, W.C.; Basten, M.A.; Kreischer, K.E.; Temkin, R.J.

1991-07-01

This report describes main activities undertaken during the period 1 June 1990 to 1 June 1991 by MIT to support the Lawrence Livermore National Laboratory tunable FEL driver project. The goal of this research was to further characterize a tunable microwave source (already identified as a BWO-gyrotron) of moderate output power (10--20 kW). In the 1989 fiscal year, the source was assembled at MIT and initial tests were conducted. Proposed for the fiscal year 1990 were analysis of the previous experimental results, and the performance of new experiments designed to increase the voltage tuning range, the output efficiency, and magnetic field tuning. During the report period the previous experimental results were analyzed and compared to computational results and new components were designed, to make the BWO ready for further experiments. In addition, the BWO-gyrotron was mounted in a new superconducting magnet and initial magnetic field profile measurements were made

Development program for a 200-kW, cw gyrotron. Quarterly report No. 9, July-September 1981

International Nuclear Information System (INIS)

Tancredi, J.J.; Caplan, M.; Matranga, V.A.; Sandoval, J.J.

1981-01-01

The objective of this program is the design and development of a millimeter-wave device to produce 200 kW of continuous-wave power at 60 GHz. The device, which will be a gyrotron oscillator, will be compatible with power delivery to an electron-cyclotron plasma. Smooth control of rf power output over a 17 dB range is required, and the device should be capable of operation into a severe time-varying rf load mismatch. The superconducting solenoid which had been sent back to the manufacturer because of an open coil, was repaired and returned to Hughes. The gyrotron S/N 1 was successfully operated at a frequency of 59.7 GHz with a power level of 160 kW peak. Diagnostic x-ray measurements of the collector area revealed a reasonable beam power density of 600 W/cm 2 , under worst case conditions of no rf output, and with no auxilary means of spreading the beam. The latter portion of this report period was spent characterizing S/N 1's rf and dc performance and evaluating an anomolous oscillation emitted from the electron gun

Characteristics of a superconducting magnet using a persistent current for a 110 GHz gyrotron

International Nuclear Information System (INIS)

Maebara, Sunao; Kasugai, Atsushi; Sakamoto, Keishi; Tsuneoka, Masaki; Imai, Tsuyoshi

1996-03-01

A superconducting magnet (SCM) using a persistent current for a 110 GHz gyrotron was developed to reduce liquid-helium loss, the boiled-off rate of 0.13 liter/hour was attained in a persistent current operation. It shows that the continuous operation for 50 days is capable without additional liquid-helium supply. Moreover, the 3040 liter in a year is used for a gyrotron test during five months and for the maintenance during seven months and liquid-helium savings of 65% was successfully demonstrated. The SCM is capable to excite the maximum magnetic field of 5.0 T in the persistent current mode. A mirror ratio between resonant cavity and magnetron injection gun (MIG) is 20 for operating the main coils in the persistent mode, since cavity coils and gun coils are connected in series. Auxiliary coils are equipped independently to control the mirror ratio, the mirror ratio of 13.6 - 37.0 at the 110 GHz is available. A two-stage refrigerator using helium gas was also installed and made liquid-nitrogen for cooling thermal shield of 80 K free. By developing this new type SCM, the number of routine works was drastically decreased in one time per 22-50 days, while routine works of a few times per week was needed up to now. (author)

Analysis of parasitic oscillations in 42 GHz gyrotron beam tunnel

Science.gov (United States)

Kumar, N.; Singh, U.; Singh, T. P.; Sinha, A. K.

2011-02-01

Parasitic oscillation excitation analysis has been carried out for the 42 GHz gyrotron beam tunnel. This article presents a systematic approach for the analysis of parasitic oscillation excitation. The electron trajectory code EGUN has been used for the estimation of the electron beam parameters in the beam tunnel. The electromagnetic simulation code CST-MS has been used for the eigenmode and Q value analysis. The analysis of the parasitic oscillations has been performed for the symmetric TE modes and the first three cavity side copper rings. Four different approaches- the Q value study, the mode maxima-electron beam radius mismatching, the electron cyclotron frequency-mode excitation frequency mismatching and the backward wave interaction analysis- have been used for the parasitic oscillation analysis.

Magnetron injection gun for a broadband gyrotron backward-wave oscillator

International Nuclear Information System (INIS)

Yuan, C. P.; Chang, T. H.; Chen, N. C.; Yeh, Y. S.

2009-01-01

The magnetron injection gun is capable of generating relativistic electron beam with high velocity ratio and low velocity spread for a gyrotron backward-wave oscillator (gyro-BWO). However, the velocity ratio (α) varies drastically against both the magnetic field and the beam voltage, which significantly limits the tuning bandwidth of a gyro-BWO. This study remedies this drawback by adding a variable trim field to adjust the magnetic compression ratio when changing the operating conditions. Theoretical results obtained by employing a two-dimensional electron gun code (EGUN) demonstrate a constant velocity ratio of 1.5 with a low axial velocity spread of 6% from 3.4-4.8 Tesla. These results are compared with a three-dimensional particle-tracing code (computer simulation technology, CST). The underlying physics for constant α will be discussed in depth.

Magnetron injection gun for a broadband gyrotron backward-wave oscillator

Science.gov (United States)

Yuan, C. P.; Chang, T. H.; Chen, N. C.; Yeh, Y. S.

2009-07-01

The magnetron injection gun is capable of generating relativistic electron beam with high velocity ratio and low velocity spread for a gyrotron backward-wave oscillator (gyro-BWO). However, the velocity ratio (α) varies drastically against both the magnetic field and the beam voltage, which significantly limits the tuning bandwidth of a gyro-BWO. This study remedies this drawback by adding a variable trim field to adjust the magnetic compression ratio when changing the operating conditions. Theoretical results obtained by employing a two-dimensional electron gun code (EGUN) demonstrate a constant velocity ratio of 1.5 with a low axial velocity spread of 6% from 3.4-4.8 Tesla. These results are compared with a three-dimensional particle-tracing code (computer simulation technology, CST). The underlying physics for constant α will be discussed in depth.

Generation of electron beams in cyclotron motion and its interaction with electromagnetic fields in weakly irregular cavities: a study applied to conceptual elaboration of a 35 GHz gyrotron

International Nuclear Information System (INIS)

Castro, J.J.B. de.

1988-12-01

It is presented an investigation of different phenomena that occur in the gyrotron: 1) generation and transport of helical electron beams, 2) interaction of electrons in cyclotron motion with a transverse electric mode in resonant cavities operating near cutoff and 3) electron deposition over the collector active region. An exact ballistic model, which points out the nonlinear attributes of the relativistic equation of electron cyclotron motion and that includes a complex formulation for the longitudinal electric field distribution in weakly irregular waveguides, is used. Physically realizable RF field profiles are studied with the objective of maximizing gyrotron efficiency. For this purpose, an investigation is made of the resonant properties of truncated cones cavities and a new resonator type, with a profile described in terms of a continuous function, is developed. High perpendicular efficiencies (η perpendicular MAX =0.86) have been calculated for interaction at the fundamental 1 cyclotron harmonic and for uniform external magnetic field. A maximum efficiency scaling parameter S has been introduced, by which scaling relations η perpendicular MAX = η perpendicular MAX (S) are applicable to a variety of field profiles. The conceptual design of a 35 GHz gyrotron gives emphasis to selection criteria of operating parameters in compliance with technical constraints and with the requirement of soft self-excited oscillations. The proposed gyrotron operates in the azimuthally symetrical mode TE 021 and is able to produce, with an electronic efficiency of 40%, an output power of 100 kW, in pulses of 20 ms, with a duty factor of 0.04%. (author) [pt

Development program for a 200 kW, CW gyrotron. Quarterly report No. 4, April-June 1980

International Nuclear Information System (INIS)

Tancredi, J.J.; Caplan, M.; Sandoval, J.J.; Weiss, W.

1980-01-01

The objective of this program is the design and development of a millimeter-wave device to produce 200 kW of continuous-wave power at 60 GHz. The device, which will be a gyrotron oscillator, will be compatible with power delivery to an electron-cyclotron plasma. Smooth control of rf power output over a 17 db range is required, and the device should be capable of operation into a severe time-varyinng rf load mismatch

Effects of INH, DNP, 2, 4-D and CMU on the sugar content of the barley and maize leaves

International Nuclear Information System (INIS)

Fernandez, J.; Sancho, P.

1979-01-01

1 ppm of the chemicals in nutritive solution was absorbed by barley and maize roots during 24 and 48 hours in dark or light conditioners in order to determine the best conditions for the obtention of labelled sugars with high specific activity. Results show that the highest specific activity was obtained in maize plants treated with DNP for 24 hours in dark conditions. (Author) 51 refs

New design for the anode power supply of a gyrotron

International Nuclear Information System (INIS)

Fasel, D.; Alberti, S.; Favre, A.; Perez, A.; Acero, J.; Ganuza, D.; Garcia, I.; Lucia, C.

1998-01-01

The introduction will remind the main supply structure installed in the CRPP, related to the ECRH (Electron Cyclotron Resonance Heating) project on the TCV (Tokamak Configuration Variable) tokamak. Then this paper concentrates on the description of the power source designed to supply the anode of the triode type gyrotron. First the requirements asked for this power supply will be presented, taking into account the possible feeding structures in relation with the existing HV DC cathode power supply. The following section will focus on the selected design, describing in details the power structure based on MOSFET, referred to the cathode potential. Afterwards the control electronics is presented, including the feedback control implemented, the HV measurements, the internal reference generator and the interface to the TCV control. Finally, the last section will give information on the project status. (author)

Initial operation of a high-power quasi-optical gyrotron

International Nuclear Information System (INIS)

Fliflet, A.W.; Hargreaves, T.A.; Manheimer, W.M.; Fischer, R.P.; Barsanti, M.L.

1990-01-01

Results from the initial operating of a high-power quasi-optical gyrotron based on the 90-kV 50-A Varian VUW-8144 electron gun are reported. The output power and efficiency have been measured for a resonator mirror separation of 19.4 cm with a magnetic field of 4.95 T, corresponding to resonator output coupling of 1.9%, and for a resonator mirror separation of 21.4 cm with a magnetic field of 4.7 T, corresponding to a resonator output coupling of 3.1%. Operation was multimoded with 3--6 modes excited in the range of 125--130 GHz for the 4.95-T magnetic field. A peak efficiency of 15% at an output power of 161 kW was obtained for a gun voltage of 93 kV and a current of 12 A. A peak-output power of 364 kW at an efficiency of 10% was obtained at a voltage of 95.6 kV and 37.5 A

Towards the optimization of the thermal–hydraulic performance of gyrotron collectors

Energy Technology Data Exchange (ETDEWEB)

Savoldi, Laura; Bertani, Cristina [Dipartimento Energia, Politecnico di Torino, 10129 Torino (Italy); Cau, Francesca; Cismondi, Fabio [F4E, Barcelona (Spain); Gantenbein, Gerd; Illy, Stefan [Karlsruhe Institute of Technology (KIT), Institute for Pulsed Power and Microwave Technology (IHM), Kaiserstr. 12, 76131 Karlsruhe (Germany); Monni, Grazia [Dipartimento Energia, Politecnico di Torino, 10129 Torino (Italy); Rozier, Yoann [Thales Electron Devices, 78141 Vélizy-Villacoublay (France); Zanino, Roberto, E-mail: roberto.zanino@polito.it [Dipartimento Energia, Politecnico di Torino, 10129 Torino (Italy)

2015-11-15

Different configurations of water-cooled Cu collector for gyrotrons are investigated using the StarCCM + CFD code, aimed at optimizing its thermal–hydraulic (TH) performance. Although the current collectors show a good performance, the collector can be subjected to transient heat loads, due to the spent electron beam, of up to several tens of MW/m{sup 2}, and there is an interest to increase the gyrotron output power in the future. Furthermore, an optimized cooling will lead to improved reliability and lifetime of the collector. Starting from a hypervapotron (HV)-like collector, characterized by 100+ deep rectangular cavities with aspect ratio (AR) = 3, we present in the first part of the paper a single-cavity steady-state parametric analysis of the effect of AR on the heat exhaust capabilities. The investigation is then extended to other collector designs, including circumferential ribs and dimples, in order to assess the options for further improvements of the TH performance. The peak Cu temperature is computed by the code and its minimization is the target of the present optimization exercise. A self-consistent estimate of the heat transfer coefficient between collector and coolant is also obtained, which could be useful for fatigue and lifetime assessments. In the second part of the paper the most promising collector geometries identified in the first part are analyzed in the case of a transient heat load (vertical sweeping), first at the level of a single spatial period of the collector structure, then at the full-collector level. The results of the TH transient analysis are compared with both the results of the first part and with the transient purely thermal analysis of the full collector, showing for all geometries considered in this study a room for cooling efficiency improvement with respect to the HV-like design with AR = 3, at least in the operating conditions considered for this study (V ∼ 4 m/s, almost 100 °C sub-cooling).

Development of a dummy load and waveguide components for 1 MW CW gyrotron

Energy Technology Data Exchange (ETDEWEB)

Ioki, Kimihiro, E-mail: ioki@toyama-jp.com [Toyama Company Limited, 3816-1 Kishi, Ymakita-machi, Ashigarakami-gun, Kanagawa 258-0112 (Japan); Hiranai, Shinichi; Moriyama, Shinichi [Naka Fusion Institute, JAEA, 801-1, Mukoyama, Naka-shi, Ibaraki 311-0193 (Japan); Tanaka, Suguru [Toyama Company Limited, 3816-1 Kishi, Ymakita-machi, Ashigarakami-gun, Kanagawa 258-0112 (Japan)

2016-11-01

Highlights: • A dummy load is a required component for the electron cyclotron heating system to test and adjust a gyrotron or a transmission line in ITER and JT60SA. • A new design concept was developed considering reliable durability and long lifetime. • Linear movement is used as a main mechanism for the reflector to mitigate the heat deposition concentration instead of rotating reflector, and the vacuum boundary for the linear movement is simply made with bellows. • The distribution of the ceramic coating thickness is carefully optimized considering the heat deposition rate. • A prototypical dummy load will be manufactured and tested, following the design phase. - Abstract: A dummy load dissipates the radiofrequency power and is required for the electron cyclotron heating system to test and adjust a gyrotron or a transmission line in ITER and JT60SA. The dummy load is comprised of a water-cooled vacuum chamber and a reflector. The vacuum chamber has intensive cooling and the inside surface has a ceramic coating layer. It is important that the dummy load has reliable durability and long lifetime. Linear movement is used as a main mechanism for the reflector to mitigate the heat deposition concentration instead of rotating reflector. The vacuum boundary for the linear movement is simply made with bellows and the bellows is accessible from the outside. The distribution of the ceramic coating thickness is carefully optimized considering the heat deposition rate. Another critical issue is to minimize the back reflection of the RF power from the dummy load. However, it is desired to design the dummy load without the pre-dummy-load. A prototypical dummy load will be manufactured and tested, following the design phase.

1 megawatt, 100 GHz gyrotron study. Final report, March 21-September 1, 1983

International Nuclear Information System (INIS)

Dionne, N.J.; Mallavarpu, R.; Palevsky, A.

1983-01-01

This report provides the results of a design study on a gyrotron device employing a new type of hollow gyrobeam formation system and having a capability for delivering megawatt CW power at 100 GHz to an ECRH-heated, magnetically-confined plasma. The conceptual basis for the beam formation system is the tilt-angle gun (TAG) in which a conically-shaped electron beam is formed in a magnetically-shielded region and is then injected into the stray-field region of the main magnetic focusing system. Because fluid coolants can be accessed through the central pole of the TAG-type gun, rf interaction can be contemplated with cavity configurations not practical with the conventional MIG-type gyrobeam formation systems

Three-Dimensional Numerical Simulation of a 30-GHz Gyrotron Resonator With an Explicit High-Order Discontinuous-Galerkin-Based Parallel Particle-In-Cell Method

DEFF Research Database (Denmark)

Stock, Andreas; Neudorfer, Jonathan; Riedlinger, Marc

2012-01-01

Fast design codes for the simulation of the particle–field interaction in the interior of gyrotron resonators are available. They procure their rapidity by making strong physical simplifications and approximations, which are not known to be valid for many variations of the geometry and the operat...

Real-Time DNP NMR Observations of Acetic Acid Uptake, Intracellular Acidification, and of Consequences for Glycolysis and Alcoholic Fermentation in Yeast

DEFF Research Database (Denmark)

Jensen, Pernille Rose; Karlsson, Magnus; Lerche, Mathilde Hauge

2013-01-01

Uptake and upshot in vivo: Straightforward methods that permit the real-time observation of organic acid influx, intracellular acidification, and concomitant effects on cellular-reaction networks are crucial for improved bioprocess monitoring and control (see scheme). Herein, dynamic nuclear pola...... polarization (DNP) NMR is used to observe acetate influx, ensuing intracellular acidification and the metabolic consequences on alcoholic fermentation and glycolysis in living cells....

Programación de un sistema de adquisición de datos utilizando el sistema embebido DNP/1110; Programming of a data acquisition system using the embedded system dil/netpc DNP/1110

Directory of Open Access Journals (Sweden)

Josnier Ramos Guardarrama

2011-06-01

Full Text Available En el trabajo se presenta una alternativa económica de un sistema de adquisición de datos (SAD basado en el kit dedesarrollo DIL/NetPC DNP/1110, el cual esta formado por un microcontrolador de INTEL SA-1110 StrongARM quetrabaja a 206 MHz y que tiene incorporado un controlador de Ethernet que permite desarrollar aplicaciones con el usode la red. El sistema embebido dispone de un sistema operativo Linux, kernel versión 2.4.18. Como parte del diseñose incorporan de forma compacta los elementos necesarios para que el SAD sea capaz de muestrear ocho señalescapturadas simultáneamente. De particular interés resulta la programación, presentándose dos variantes de solución:cuando se ejecuta la aplicación con un software que corre en el área de usuario y cuando el control se logra con unmódulo del sistema operativo específico para el trabajo del SAD. El sistema está soportado por la integración desoftware libre y propietario.  This work focuses on an economic alternative for developing a data acquisition system (DAS which is made up forThe DIL/NetPC DNP/1110, which provides a very compact Intel 206 MHz SA-1110 StrongARM-based low powerembedded controller with TCP/IP stack and web server for high-speed embedded networking applications. Theembedded system has an operating system Linux, kernel version 2.4.18. The built data acquisition system has thenecessary elements to take charge of governing the sampling process of eight signals. Of particular interest it is theprogramming, being presented two solution variants: when the application is executed with software that it runs inuser's area and when the control is achieved with a specific build module of the operating system for the work of theDAS.. The system is supported by the integration of free software and property software.

Programación de un sistema de adquisición de datos utilizando el sistema embebido DNP/1110;Programming of a data acquisition system using the embedded system dil/netpc DNP/1110

Directory of Open Access Journals (Sweden)

Josnier Ramos - Guardarrama,et al.

2011-06-01

Full Text Available En el trabajo se presenta una alternativa económica de un sistema de adquisición de datos (SAD basado en el kit de desarrollo DIL/NetPC DNP/1110, el cual esta formado por un microcontrolador de INTEL SA-1110 StrongARM que trabaja a 206 MHz y que tiene incorporado un controlador de Ethernet que permite desarrollar aplicaciones con el uso de la red. El sistema embebido dispone de un sistema operativo Linux, kernel versión 2.4.18. Como parte del diseño se incorporan de forma compacta los elementos necesarios para que el SAD sea capaz de muestrear ocho señales capturadas simultáneamente. De particular interés resulta la programación, presentándose dos variantes de solución: cuando se ejecuta la aplicación con un software que corre en el área de usuario y cuando el control se logra con un módulo del sistema operativo específico para el trabajo del SAD. El sistema está soportado por la integración de software libre y propietario.This work focuses on an economic alternative for developing a data acquisition system (DAS which is made up for The DIL/NetPC DNP/1110, which provides a very compact Intel 206 MHz SA-1110 StrongARM-based low power embedded controller with TCP/IP stack and web server for high-speed embedded networking applications. The embedded system has an operating system Linux, kernel version 2.4.18. The built data acquisition system has the necessary elements to take charge of governing the sampling process of eight signals. Of particular interest it is the programming, being presented two solution variants: when the application is executed with software that it runs in user's area and when the control is achieved with a specific build module of the operating system for the work of the DAS.. The system is supported by the integration of free software and property software.

Design considerations in achieving 1 MW CW operation with a whispering-gallery-mode gyrotron

International Nuclear Information System (INIS)

Felch, K.; Feinstein, J.; Hess, C.; Huey, H.; Jongewaard, E.; Jory, H.; Neilson, J.; Pendleton, R.; Pirkle, D.; Zitelli, L.

1989-09-01

Varian is developing high-power, CW gyrotrons at frequencies in the range 100 GHz to 150 GHz, for use in electron cyclotron heating applications. Early test vehicles have utilized a TE 15,2,1 interaction cavity, have achieved short-pulse power levels of 820 kW and average power levels of 80 kW at 140 GHz. Present tests are aimed at reaching 400 kW under CW operating conditions and up to 1 MW for short pulse durations. Work is also underway on modifications to the present design that will enable power levels of up to 1 MW CW to be achieved. 7 refs., 2 figs

Experimental measurements of competition between fundamental and second harmonic emission in a quasi-optical gyrotron

International Nuclear Information System (INIS)

Alberti, S.; Pedrozzi, M.; Tran, M.Q.; Hogge, J.P.; Tran, T.M.; Muggli, P.; Joedicke, B.; Mathews, H.G.

1990-04-01

A quasi-optical gyrotron (QOG) designed for operation at the fundamental (Ω ce ≅100 GHz) exhibits simultaneous emission at Ω ce and 2Ω ce (second harmonic). For a beam current of 4 A, 20% of the total RF power is emitted at the second harmonic. The experimental measurements show that the excitation of the second harmonic is only possible when the fundamental is present. The frequency of the second harmonic is locked by the frequency of the fundamental. Experimental evidence shows that when the second harmonic is not excited, total efficiency is enhanced. (author) 6 refs., 5 figs., 1 tab

Numerical optimization of quasi-optical mode converter for frequency step-tunable gyrotron

International Nuclear Information System (INIS)

Drumm, O.

2002-08-01

This work concentrates on the design of a quasi-optical mode converter for a frequency step-tunable gyrotron. Special attention is paid to the optimization of the conversion and forming of the exited wave of different frequencies inside the resonator. The investigations were part of the HGF-strategy-fonds-project ''Optimization of Tokamak Operation with controlled ECRH-Deposition''. In the resonator of the gyrotron modes can be exited at frequencies between 105 and 140 GHz. With the designed converter the desired field distribution at the output window for all frequencies will be approximately obtained. The newly gained knowledge and invented synthesis methods are applied to this practical example and verified. In this work, the waveguide antenna and the mirror system of the quasi-optical mode converter are presented separately from each other. At the beginning the synthesis of the aperture antenna for a frequency step-tunable design of the Vlasov-type as well as the Denisov-type is considered. As a conclusion of the investigation, the important parameters for the design of all antennas are summarized and the frequency behavior is compared. In the second part of this work new broadband design methods for the synthesis of the mirror surface are presented. These mirrors make an optimal wave forming for all frequencies equally possible. Therefore new quality criteria are introduced for the broadband evaluation of the mirror. Afterwards the surface is varied until the criteria reach an optimum. For the numerical optimization, in this work the gradient method and the extended Katsenelenbaum-Semenov algorithm are invented and applied. The efficient realization of the described algorithms on a computer is the significant point. The theoretical background of the presented methods for the synthesis of a mirror system is based on the general solution of the Helmholtz equation. Due to this, these methods can be utilized in other fields outside the microwave applications in

Design of test JIG for centralized interlock and protection module of ITER-India Gyrotron Test Facility

International Nuclear Information System (INIS)

Rathod, Vipal; Rao, S.L.; Edappala, Praveenlal; Rajpal, Rachana

2017-01-01

Fast Interlock and protection system plays very crucial role in ensuring the safe and reliable operation of high power RF sources such as a Gyrotron system. Critical Protection Interlocks are generally implemented using hardwired components and are required to have a response time as fast as < 10 μs. In this context, an Industrial grade prototype Centralized Interlock and Protection Module (CIM) based on ITER-India design has been developed successfully with the help of local industry. This paper presents the complete requirements, approach, detailed design concept and current status of Test JIG in detail

Effects of INH, DNP, 2, 4-D and CMU on the sugar content of the barley and maize leaves; Efecto de cuatro inhibidores metabolicos (INH, DNP, 2, 3-D y CMU) sobre el contenido en azucares de hohas de cebada (Hordeum vulgare L.) y Maiz (Zea mais L.)

Energy Technology Data Exchange (ETDEWEB)

Fernandez, J; Sancho, P

1979-07-01

1 ppm of the chemicals in nutritive solution was absorbed by barley and maize roots during 24 and 48 hours in dark or light conditioners in order to determine the best conditions. for the obtention of labelled sugars with high specific activity. Results show that the highest specific activity was obtained In maize plants treated with DNP for 24 hours in dark conditions. (Author) 51 refs.

Nonstationary oscillation of gyrotron backward wave oscillators with cylindrical interaction structure

International Nuclear Information System (INIS)

Chen, Shih-Hung; Chen, Liu

2013-01-01

The nonstationary oscillation of the gyrotron backward wave oscillator (gyro-BWO) with cylindrical interaction structure was studied utilizing both steady-state analyses and time-dependent simulations. Comparisons of the numerical results reveal that the gyro-BWO becomes nonstationary when the trailing field structure completely forms due to the dephasing energetic electrons. The backward propagation of radiated waves with a lower resonant frequency from the trailing field structure interferes with the main internal feedback loop, thereby inducing the nonstationary oscillation of the gyro-BWO. The nonstationary gyro-BWO exhibits the same spectral pattern of modulated oscillations with a constant frequency separation between the central frequency and sidebands throughout the whole system. The frequency separation is found to be scaled with the square root of the maximum field amplitude, thus further demonstrating that the nonstationary oscillation of the gyro-BWO is associated with the beam-wave resonance detuning

Toxicology Study No. S.0024589d 15, Human Cell Line Activation Test of the Novel Energetic, 3,4 -Dinitropyrazole (DNP)

Science.gov (United States)

2016-04-01

Assay 1 0.259 0.278 Assay 2 0.299 6.3 CD54 and CD86 expression in response to DNP exposure of THP -1 cells Three independent tests were...2 Toxicology Study No. S.0024589d-15, April 2016 Toxicology Directorate Human Cell Line Activation Test of the Novel Energetic 3,4...report. 17-05-2016 Technical Report March 2016-April 2016 Toxicology Study No. S.0024589d-15 Human Cell Line Activation Test of the Novel

Dielectric properties during electron irradiation of alternative materials for gyrotron windows

International Nuclear Information System (INIS)

Vila, R.; Ibarra, A.; Hodgson, E.R.

1996-01-01

Recent work on high power gyrotron windows has focused interest on some homopolar insulators as alternatives to sapphire due to their combined low dielectric loss and high thermal conductivity. The two main candidates at this moment, CVD diamond and high resistivity silicon, have been studied. As an indicator of their radiation behaviour, loss tangent and permittivity at about 15 GHz have been measured under 1.8 MeV electron irradiation at RT. In the case of silicon the previously observed radiation-induced decrease of loss tangent has been confirmed reaching a lower saturation level of 3.5 x 10 -5 at higher doses, and falling with increasing frequency. An even more important observation is that the sensitivity to ionizing radiation dropped by 4 orders of magnitude due to the radiation dose. First results for diamond are also promising, only a small degradation at relatively short times being seen with no further changes up to the maximum dose used. (orig.)

Intense high-frequency gyrotron-based microwave beams for material processing

Energy Technology Data Exchange (ETDEWEB)

Hardek, T.W.; Cooke, W.D.; Katz, J.D.; Perry, W.L.; Rees, D.E.

1997-03-01

Microwave processing of materials has traditionally utilized frequencies in the 0.915 and 2.45 GHz regions. Microwave power sources are readily available at these frequencies but the relatively long wavelengths can present challenges in uniformly heating materials. An additional difficulty is the poor coupling of ceramic based materials to the microwave energy. Los Alamos National Laboratory scientists, working in conjunction with the National Center for Manufacturing Sciences (NCMS), have assembled a high-frequency demonstration processing facility utilizing gyrotron based RF sources. The facility is primarily intended to demonstrate the unique features available at frequencies as high as 84 GHz. The authors can readily provide quasi-optical, 37 GHz beams at continuous wave (CW) power levels in the 10 kW range. They have also provided beams at 84 GHz at 10 kW CW power levels. They are presently preparing a facility to demonstrate the sintering of ceramics at 30 GHz. This paper presents an overview of the present demonstration processing facility and describes some of the features they have available now and will have available in the near future.

Design of a double-anode magnetron-injection gun for the W-band gyrotron

Science.gov (United States)

Jang, Kwang Ho; Choi, Jin Joo; So, Joon Ho

2015-07-01

A double-anode magnetron-injection gun (MIG) was designed. The MIG is for a W-band 10-kW gyrotron. Analytic equations based on adiabatic theory and angular momentum conservation were used to examine the initial design parameters such as the cathode angle, and the radius of the beam emitting surface. The MIG's performances were predicted by using an electron trajectory code, the EGUN code. The beam spread of the axial velocity, Δvz/vz, obtained from the EGUN code was observed to be 1.34% at α = 1.3. The cathode edge emission and the thermal effect were modeled. The cathode edge emission was found to have a major effect on the velocity spread. The electron beam's quality was significantly improved by affixing non-emissive cylinders to the cathode.

The three-dimensional particle-in-cell simulation analysis of cavity of high power subterahertz pulsed gyrotron

International Nuclear Information System (INIS)

Ito, Koyu; Jiang, Weihua

2013-01-01

High power sub-terahertz pulsed gyrotrons for Collective Thomson Scattering (CTS) diagnostics of fusion plasmas are being developed. The typical target parameters are: output power of 100-200 kW, operation frequency of 300 GHz, and pulsed length > 10 us. In order to support experimental development, numerical simulations were carried out by using Particle-In-Cell (PIC) code MAGIC. The oscillation mode of the electromagnetic radiation was selected as TE_1_5_,_2, for which the beam parameters and cavity dimensions were determined accordingly. The simulation results have showed maximum power of 144 kW at oscillation frequency of 292.80 GHz, with oscillation efficiency of 22.15%. (author)

High power microwave diagnostic for the fusion energy experiment ITER

DEFF Research Database (Denmark)

Korsholm, Søren Bang; Leipold, Frank; Goncalves, B.

2016-01-01

Microwave diagnostics will play an increasingly important role in burning plasma fusion energy experiments like ITER and beyond. The Collective Thomson Scattering (CTS) diagnostic to be installed at ITER is an example of such a diagnostic with great potential in present and future experiments....... The ITER CTS diagnostic will inject a 1 MW 60 GHz gyrotron beam into the ITER plasma and observe the scattering off fluctuations in the plasma — to monitor the dynamics of the fast ions generated in the fusion reactions....

Cold test measurements on components of the 1 MW, 140 GHz, CW gyrotron for the stellarator Wendelstein 7-X

International Nuclear Information System (INIS)

Dammertz, G.; Alberti, S.; Arnold, A.; Giguet, E.; LeGoff, Y.; Thumm, M.

2001-01-01

For the development of a 1 MW, 140 GHz gyrotron for CW operation which will be installed at the stellarator facility Wendelstein 7-X at IPP Greifswald, a collaboration between different European research institutes and an industrial company has been established. In order to prove the proper functioning of the millimeter wave components installed in the gyrotron -- such as the cavity, the waveguide taper and the quasioptical mode converter -- these components should be cold tested, preferably before installation. However, due to lack of time as well as long delivery times, this was not possible. Therefore, two units of the quasioptical mode converter and the cavity were fabricated with identical geometry, one of those being used for measurements on the low power test device. To perform these cold tests for tapers and mode converters, the gyrotron cavity output mode has to be simulated. This means that a high order rotating mode (TE 28,8 mode) must be generated at low power. This can be achieved by means of a mode generator consisting of two mirrors and a coaxial cavity with a perforated outer wall. Before applying the mode generator to the components, its proper behavior and the accurate alignment of the system must be verified either by radiation pattern measurements or k-spectrometer measurements. As the coupling through the holes of the k-spectrometer is extremely low, a special vector network analyzer with a dynamic range of at least 100 dB had to be developed. This has been achieved by integration of a phase locked backward-wave oscillator with a line width of 100 Hz and an output power of 10 mW. A non-destructive measurement of the resonance frequency and the quality factor of the cavity does not seem possible. The second cavity will be prepared for the cold measurement by drilling a small radial hole into its wall in the plane of the field maximum. This hole is then used for the input coupling. The accuracy required for this hole is rather critical. The

Comparative analysis of gyrotron backward-wave oscillators operating at different cyclotron harmonics

International Nuclear Information System (INIS)

Yeh, Y.S.; Chang, T.H.; Wu, T.S.

2004-01-01

A comparative analysis between the fundamental and second cyclotron harmonics of gyrotron backward-wave oscillators (gyro-BWOs) is presented. The simulation results reveal that nonlinear field contraction is a common feature for both harmonic interactions. Besides, the electron transit angle, used to characterize the axial modes of the fundamental harmonic TE 11 mode at the start-oscillation conditions, is found to be applicable even for the second harmonic TE 21 mode. Each axial mode of either the fundamental harmonic TE 11 or the second harmonic TE 21 modes is maintained at a constant value of the electron transit angle while changing the operating parameters, such as magnetic field and beam voltage. Extensive numerical calculations are conducted for the start-oscillation currents and tuning properties. Moreover, single-mode operating regimes are suggested where the second harmonic TE 21 gyro-BWO could generate a considerable output power, comparing with the fundamental harmonic TE 11 gyro-BWO

Numerical Simulation of Single-anode and Double-anode Magnetron Injection Guns for 127.5 GHz 1 MW Gyrotron

Science.gov (United States)

Singh, Udaybir; Kumar, Nitin; Kumar, Anil; Purohit, Laxmi Prasad; Sinha, Ashok Kumar

2011-07-01

This paper presents the design of two types of magnetron injection guns (MIG's) for 1 MW, 127.5 GHz gyrotron. TE24,8 mode has been chosen as the operating mode. In-house developed code MIGSYN has been used to estimate the initial gun parameters. The electron trajectory tracing program EGUN and in-house developed code MIGANS have been used to optimize the single-anode and the double-anode design for 80 kV, 40 A MIG. The parametric analysis of MIG has also been presented. The advantages and the disadvantages of each kind of configuration have been critically examined.

Micro-pulses generation in ECR breakdown stimulated by gyrotron radiation at 37,5 GHz

International Nuclear Information System (INIS)

Skalyga, V.; Zorin, V.; Izotov, I.; Golubev, S.; Razin, S.; Sidorov, A.; Vodopyanov, A.

2012-01-01

The present work is devoted to experimental and theoretical investigation of the creation of short pulsed (< 100 μs) multicharged ion beams. The possibility of quasi-stationary generation of short pulsed beams under conditions of quasi-gasdynamic plasma confinement was shown in recent experiments. Later another way of such beams creation based on the Pre-glow effect was proposed. In present work it was demonstrated that in the case when duration of microwave (MW) pulse is less than formation time of Pre-glow peak, realization of a regime when ion current is negligible during MW pulse and intense multicharged ions flux appears only when MW ends could be possible. Such pulses after the end of MW were called micro-pulses. In the present work the generation of micro-pulses was observed in experiments with ECR discharge stimulated by gyrotron radiation at 37,5 GHz, 100 kW. In this case pulses with duration less than 30 μs were obtained. Probably the same effect was observed in GANIL where 14 GHz radiation was used and pulses with duration about 2 ms were registered. In present work it was shown that the intensity of such micro-pulse could be higher than intensity of Pre-glow peak at the same conditions but with longer MW pulse. The generation of micro-pulses of nitrogen and argon multicharged ions with current of a few mA and length about 30 μs after MW pulse with duration of 30-100 μs was demonstrated. The low level of impurities, high current density and rather high average charge make possible to consider such micro-pulse regime as a possibility for the creation of a short pulsed ion source. The paper is followed by the slides of the presentation. (authors)

Design, Synthesis and DFT/DNP Modeling Study of New 2-Amino-5-arylazothiazole Derivatives as Potential Antibacterial Agents

Directory of Open Access Journals (Sweden)

Sraa Abu-Melha

2018-02-01

Full Text Available A new series of 2-amino-5-arylazothiazole derivatives has been designed and synthesized in 61–78% yields and screened as potential antibacterial drug candidates against the Gram negative bacterium Escherichia coli. The geometry of the title compounds were being studied using the Material Studio package and semi-core pseudopods calculations (dspp were performed with the double numerica basis sets plus polarization functional (DNP to predict the properties of materials using the hybrid FT/B3LYP method. Modeling calculations, especially the (EH-EL difference and the energetic parameters revealed that some of the title compounds may be promising tools for further research work and the activity is structure dependent.

Initial results of a high-power microwave sintering experiment at ORNL

International Nuclear Information System (INIS)

Kimrey, H.D.; White, T.L.; Bigelow, T.S.; Becher, P.F.

1986-01-01

Experiments have recently begun at Oak Ridge National Laboratory to develop microwave sintering techniques suitable for large ceramic parts. Microwave sintering offers the advantages of faster heating rates, more uniform heating, and greater energy efficiency than conventional sintering techniques. We are using 28-GHz, 200-kW cw gyrotrons as the heating source. An untuned cavity is used as the applicator to eliminate geometry sensitivity in coupling efficiency

Experiments on hot-electron ECRH in the Tandem Mirror Experiment-Upgrade

International Nuclear Information System (INIS)

Stallard, B.W.

1983-01-01

Experiments have begun on the Tandem Mirror Experiment Upgrade (TMX-U) using electron-cyclotron resonant heating (ECRH) to generate the hot electron populations required for thermal barrier operation (Energy E/sub eh/ approx. 50 keV, density n/sub eh/ 12 , and hot-to-cold fraction n/sub eh/n approx. 0.9). For this operation, rf power produced by 28-GHz gyrotrons is injected with extraordinary mode polarization at both fundamental and second harmonic locations. Our initial experiments, which concentrated on startup of the hot electrons, were carried out at low density ( 12 cm - 3 ) where Fokker-Planck calculations predict high heating efficiency when the electron temperature (T/sub e/) is low. Under these conditions, we produced substantial hot electron populations (diamagnetic energy > 400 J, E/sub eh/ in the range of 15 to 50 keV, and n/sub eh//n > 0.5)

Commissioning a Megawatt-class Gyrotron with Collector Potential Depression

Science.gov (United States)

Lohr, J.; Cengher, M.; Gorelov, Y. A.; Ponce, D.; Prater, R.

2013-10-01

A 110 GHz depressed collector gyrotron has been installed on the DIII-D tokamak. The commissioning process rapidly achieved operation at full parameters, 45 A and 94 kV total voltage, with 29 kV depression. Although short pulse, 2 ms, factory testing demonstrated 1.2 MW at 41% electrical efficiency, long pulse testing at DIII-D achieved only 33% efficiency at full power parameters, for pulse lengths up to 10 s. Maximum generated power was ~950 kW, considerably below the 1.2 MW target. During attempts to increase the power at 5 s pulse length, it was noted that the collector cooling water was boiling. This led to the discovery that 14 of the 160 cooling channels in the collector had been blocked by braze material during manufacture of the tube. The locations of blocked channels were identified using infrared imaging of the outside of the collector during rapid changes in the cooling water temperature. Despite these difficulties, the rf beam itself was of very high quality and the stray rf found calorimetrically in the Matching Optics Unit, which couples the Gaussian rf beam to the waveguide, was only 2% of the generated power, about half that of our previous best quality high power beam. Details of the power measurements and collector observations will be presented. Work supported by the US DOE under DE-FC02-04ER54698.

Insight into the Supramolecular Architecture of Intact Diatom Biosilica from DNP-Supported Solid-State NMR Spectroscopy.

Science.gov (United States)

Jantschke, Anne; Koers, Eline; Mance, Deni; Weingarth, Markus; Brunner, Eike; Baldus, Marc

2015-12-07

Diatom biosilica is an inorganic/organic hybrid with interesting properties. The molecular architecture of the organic material at the atomic and nanometer scale has so far remained unknown, in particular for intact biosilica. A DNP-supported ssNMR approach assisted by microscopy, MS, and MD simulations was applied to study the structural organization of intact biosilica. For the first time, the secondary structure elements of tightly biosilica-associated native proteins in diatom biosilica were characterized in situ. Our data suggest that these proteins are rich in a limited set of amino acids and adopt a mixture of random-coil and β-strand conformations. Furthermore, biosilica-associated long-chain polyamines and carbohydrates were characterized, thereby leading to a model for the supramolecular organization of intact biosilica. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Enhancement of oscillation characteristics of a gyrotron by a built-in quasi-optical mode converter

International Nuclear Information System (INIS)

Hayashi, Kenichi; Mitsunaka, Yoshika; Komuro, Mitsuo

1994-01-01

Oscillation characteristics are analyzed experimentally and numerically by using two gyrotrons with a power level of 500 kW, a conventional tube and a tube with a built-in quasi-optical mode converter. Both tubes have a 120 GHz, TE 12,2 cavity of the same geometry and a single disk alumina window. The quasi-optical mode converter consists of an α-cut launcher and five mirrors. In the conventional tube, reflection of the competing mode at the output window prevents the main mode from oscillating stably in the operation region predicted by the design. Mode selectivity of the quasi-optical mode converter removes the influence of the reflection on the oscillation. Consequently, the experimental results in the tube with the quasi-optical mode converter are in good agreement with the design values. (author)

Mechanical reliability of current alumina and beryllia ceramics used in microwave windows for gyrotrons

International Nuclear Information System (INIS)

Becher, P.F.; Ferber, M.K.

1983-02-01

The mechanical reliability was evaluated for the alumina and beryllia ceramics now used as microwave windows in the high-power (greater than or equal to 200 kW) high-frequency (greater than or equal to 60 GHz) gyrotron tubes being developed for plasma heating in fusion systems. Analysis of the stresses generated in the various window configurations and tube operating conditions indicated that significant tensile stresses are generated in the ceramic window by dielectric heating. As a result, we characterized the static and dynamic fatigue behavior and the inert strength distributions for these two ceramics (i.e., fatigue studies included the behavior in the fluorocarbon fluid used for window cooling at 22 and 48 0 C and in both air (65% relative humidity) and distilled water at 22 0 C. These data were then analyzed in order to construct reliability diagrams for these materials

PXIe based data acquisition and control system for ECRH systems on SST-1 and Aditya tokamak

Energy Technology Data Exchange (ETDEWEB)

Patel, Jatinkumar J., E-mail: jatin@ipr.res.in [Institute for Plasma Research, Bhat, Gandhinagar (India); Shukla, B.K.; Rajanbabu, N.; Patel, H.; Dhorajiya, P.; Purohit, D. [Institute for Plasma Research, Bhat, Gandhinagar (India); Mankadiya, K. [Optimized Solutions Pvt. Ltd (India)

2016-11-15

Highlights: • Data Aquisition and control system (DAQ). • PXIe hardware–(PXI–PCI bus extension for Instrumention Express). • RHVPS–Regulated High Voltage Power supply. • SST1–Steady state superconducting tokamak. - Abstract: In Steady State Superconducting (SST-1) tokamak, various RF heating sub-systems are used for plasma heating experiments. In SST-1, Two Electron Cyclotron Resonance Heating (ECRH) systems have been installed for pre-ionization, heating and current drive experiments. The 42 GHz gyrotron based ECRH system is installed and in operation with SST-1 plasma experiments. The 82.6 GHz gyrotron delivers 200 kW CW power (1000 s) while the 42 GHz gyrotron delivers 500 kW power for 500 ms duration. Each gyrotron system consists of various auxiliary power supplies, the crowbar unit and the water cooling system. The PXIe (PCI bus extension for Instrumentation Express)bus based DAC (Data Acquisition and Control) system has been designed, developed and under implementation for safe and reliable operation of the gyrotron. The Control and Monitoring Software applications have been developed using NI LabView 2014 software with real time support on windows platform.

PXIe based data acquisition and control system for ECRH systems on SST-1 and Aditya tokamak

International Nuclear Information System (INIS)

Patel, Jatinkumar J.; Shukla, B.K.; Rajanbabu, N.; Patel, H.; Dhorajiya, P.; Purohit, D.; Mankadiya, K.

2016-01-01

Highlights: • Data Aquisition and control system (DAQ). • PXIe hardware–(PXI–PCI bus extension for Instrumention Express). • RHVPS–Regulated High Voltage Power supply. • SST1–Steady state superconducting tokamak. - Abstract: In Steady State Superconducting (SST-1) tokamak, various RF heating sub-systems are used for plasma heating experiments. In SST-1, Two Electron Cyclotron Resonance Heating (ECRH) systems have been installed for pre-ionization, heating and current drive experiments. The 42 GHz gyrotron based ECRH system is installed and in operation with SST-1 plasma experiments. The 82.6 GHz gyrotron delivers 200 kW CW power (1000 s) while the 42 GHz gyrotron delivers 500 kW power for 500 ms duration. Each gyrotron system consists of various auxiliary power supplies, the crowbar unit and the water cooling system. The PXIe (PCI bus extension for Instrumentation Express)bus based DAC (Data Acquisition and Control) system has been designed, developed and under implementation for safe and reliable operation of the gyrotron. The Control and Monitoring Software applications have been developed using NI LabView 2014 software with real time support on windows platform.

Optimizing the coupling of output of a quasi-optical gyrotron owing to a diffraction grating with ellipsoidal support

International Nuclear Information System (INIS)

Hogge, J.P.

1993-12-01

The output scheme of a quasi-optical gyrotron has been optimized in order to produce a gaussian output microwave beam suitable for transmission over long distances. The technique which has been applied consists of substituting one of the mirrors of the Fabry-Perot resonator in which the particle-wave interaction takes place by a diffraction grating placed in the -1 order Littrow mount and designed such that only orders -1 and 0 can propagate. In such a configuration, the diffraction angle of the order -1 coincides exactly with the incidence direction, thus providing a feedback in the cavity, whereas the order 0 constitutes the output of the resonator. A theoretical study of the power content in each diffracted order of a planar grating of infinite extent with equally spaced linear grooves as a function of the grating parameters has been performed. It has been shown that parameter domains can be found, which provide appropriate efficiencies in both orders for an application on a quasi-optical gyrotron. The Littrow condition was then adapted in order to match the spherical wavefronts of a gaussian beam incident on a possibly non-planar surface. The grooves become thus curvilinear and are no longer equally spaced. Measurements made on a cold test stand have confirmed the validity of the Littrow condition extension and allowed to determine its limits. It has also been shown that this type of cavity provides a mode having an optimal gaussian content and giving a minimal cavity transmission. The angular dispersion of the grating leads to a higher cavity transmission and to a slightly lower gaussian content for the adjacent resonator modes. The fundamental eigenmode electric field profile has been measured inside the cavity and is similar to that of an equivalent resonator made with two spherical mirrors. (author) figs., tabs., 141 refs

Design of 95 GHz gyrotron based on continuous operation copper solenoid with water cooling

International Nuclear Information System (INIS)

Borodin, Dmitri; Ben-Moshe, Roey; Einat, Moshe

2014-01-01

The design work for 2nd harmonic 95 GHz, 50 kW gyrotron based on continuous operation copper solenoid is presented. Thermionic magnetron injection gun specifications were calculated according to the linear trade off equation, and simulated with CST program. Numerical code is used for cavity design using the non-uniform string equation as well as particle motion in the “cold” cavity field. The mode TE02 with low Ohmic losses in the cavity walls was chosen as the operating mode. The Solenoid is designed to induce magnetic field of 1.8 T over a length of 40 mm in the interaction region with homogeneity of ±0.34%. The solenoid has six concentric cylindrical segments (and two correction segments) of copper foil windings separated by water channels for cooling. The predicted temperature in continuous operation is below 93 °C. The parameters of the design together with simulation results of the electromagnetic cavity field, magnetic field, electron trajectories, and thermal analyses are presented

Design of 95 GHz gyrotron based on continuous operation copper solenoid with water cooling

Energy Technology Data Exchange (ETDEWEB)

Borodin, Dmitri; Ben-Moshe, Roey; Einat, Moshe [Department of Electrical and Electronic Engineering, Ariel University, Ariel 40700 (Israel)

2014-07-15

The design work for 2nd harmonic 95 GHz, 50 kW gyrotron based on continuous operation copper solenoid is presented. Thermionic magnetron injection gun specifications were calculated according to the linear trade off equation, and simulated with CST program. Numerical code is used for cavity design using the non-uniform string equation as well as particle motion in the “cold” cavity field. The mode TE02 with low Ohmic losses in the cavity walls was chosen as the operating mode. The Solenoid is designed to induce magnetic field of 1.8 T over a length of 40 mm in the interaction region with homogeneity of ±0.34%. The solenoid has six concentric cylindrical segments (and two correction segments) of copper foil windings separated by water channels for cooling. The predicted temperature in continuous operation is below 93 °C. The parameters of the design together with simulation results of the electromagnetic cavity field, magnetic field, electron trajectories, and thermal analyses are presented.

Numerical investigation of collector cooling for a 1 MW ITER gyrotron operated with vertical sweeping

Energy Technology Data Exchange (ETDEWEB)

Savoldi, Laura; Bertani, Cristina [Dipartimento Energia, Politecnico di Torino (Italy); Cau, Francesca; Cismondi, Fabio [Fusion for Energy, Barcelona (Spain); Gantenbein, Gerd; Illy, Stefan [KIT, Karlsruhe (Germany); Monni, Grazia [Dipartimento Energia, Politecnico di Torino (Italy); Zanino, Roberto, E-mail: roberto.zanino@polito.it [Dipartimento Energia, Politecnico di Torino (Italy)

2015-11-15

The present gyrotron designs for EC plasma heating in nuclear fusion reactors require the safe exhaust of a power comparable to that injected into the plasma, in order to keep the maximum temperature below the acceptable value of 300 °C. In this paper, the commercial computational fluid dynamics (CFD) software STAR-CCM+{sup ®} is used to analyze the thermal performance of the annular copper collector of a 1 MW ITER gyrotron, equipped with a hypervapotron structure made of annular fins with rectangular cavities of aspect ratio (depth/width) = 3, cooled by highly subcooled (90–100 °C) pressurized water flowing at ∼4 m/s. It is assumed that the simple vertical sweeping strategy is used to reduce the very high peak heat flux on the collector (up to 30 MW/m{sup 2} transient, 5 MW/m{sup 2} time average), due to the spent electron beam. The 2D steady-state conjugate heat transfer problem is solved assuming azimuthal symmetry and accounting for 2-phase flow. The single-cavity flow and heat transfer problem is considered first, to optimize the mesh and the selection of the turbulence model. For the operating conditions considered in this paper, the full collector (100+ cavities) solution shows that boiling occurs only in a limited number of cavities close to the peaks of the heat flux, with the vapor remaining trapped in the bottom of the cavities, i.e. no full hypervapotron regime should be achieved in these operating conditions. The steady-state analysis allows the numerical evaluation of the heat transfer coefficients between Cu and water; these are then used as input for the simplified, purely thermal (solid only) analysis of the actual transient problem for the full collector. The results of the simplified model, which allows a huge reduction of the computational effort, are successfully benchmarked against those of a comprehensive thermal–hydraulic simulation. The computed peak Cu temperature is below the acceptable limit under the steady-state (time averaged

Neutron generator for BNCT based on high current ECR ion source with gyrotron plasma heating.

Science.gov (United States)

Skalyga, V; Izotov, I; Golubev, S; Razin, S; Sidorov, A; Maslennikova, A; Volovecky, A; Kalvas, T; Koivisto, H; Tarvainen, O

2015-12-01

BNCT development nowadays is constrained by a progress in neutron sources design. Creation of a cheap and compact intense neutron source would significantly simplify trial treatments avoiding use of expensive and complicated nuclear reactors and accelerators. D-D or D-T neutron generator is one of alternative types of such sources for. A so-called high current quasi-gasdynamic ECR ion source with plasma heating by millimeter wave gyrotron radiation is suggested to be used in a scheme of D-D neutron generator in the present work. Ion source of that type was developed in the Institute of Applied Physics of Russian Academy of Sciences (Nizhny Novgorod, Russia). It can produce deuteron ion beams with current density up to 700-800 mA/cm(2). Generation of the neutron flux with density at the level of 7-8·10(10) s(-1) cm(-2) at the target surface could be obtained in case of TiD2 target bombardment with deuteron beam accelerated to 100 keV. Estimations show that it is enough for formation of epithermal neutron flux with density higher than 10(9) s(-1) cm(-2) suitable for BNCT. Important advantage of described approach is absence of Tritium in the scheme. First experiments performed in pulsed regime with 300 mA, 45 kV deuteron beam directed to D2O target demonstrated 10(9) s(-1) neutron flux. This value corresponds to theoretical estimations and proofs prospects of neutron generator development based on high current quasi-gasdynamic ECR ion source. Copyright © 2015 Elsevier Ltd. All rights reserved.

Excitation-energy dependence of the resonant Auger transitions to the 4p4(1D)np (n=5,6) states across the 3d3/2-15p and 3d5/2-16p resonances in Kr

International Nuclear Information System (INIS)

Sankari, A.; Alitalo, S.; Nikkinen, J.; Kivimaeki, A.; Aksela, S.; Aksela, H.; Fritzsche, S.

2007-01-01

The energy dependencies of the intensities and angular distribution parameters β of the resonant Auger final states 4p 4 ( 1 D)np (n=5,6) of Kr were determined experimentally in the excitation-energy region of the overlapping 3d 3/2 -1 5p and 3d 5/2 -1 6p resonances. The experimental results were compared with the outcome of multiconfiguration Dirac-Fock calculations. Combining experimental and calculated results allowed us to study interference effects between the direct and several resonant channels that populate the 4p 4 ( 1 D)np states. The inclusion of the direct channel was crucial in order to reproduce the observed energy behavior of the angular distribution parameters. It was also important to take into account experimentally observed shake transitions

Low-order-mode harmonic multiplying gyrotron traveling-wave amplifier in W band

International Nuclear Information System (INIS)

Yeh, Y. S.; Chen, C. H.; Yang, S. J.; Lai, C. H.; Lin, T. Y.; Lo, Y. C.; Hong, J. W.; Hung, C. L.; Chang, T. H.

2012-01-01

Harmonic multiplying gyrotron traveling-wave amplifiers (gyro-TWAs) allow for magnetic field reduction and frequency multiplication. To avoid absolute instabilities, this work proposes a W-band harmonic multiplying gyro-TWA operating at low-order modes. By amplifying a fundamental harmonic TE 11 drive wave, the second harmonic component of the beam current initiates a TE 21 wave to be amplified. Absolute instabilities in the gyro-TWA are suppressed by shortening the interaction circuit and increasing wall losses. Simulation results reveal that compared with Ka-band gyro-TWTs, the lower wall losses effectively suppress absolute instabilities in the W-band gyro-TWA. However, a global reflective oscillation occurs as the wall losses decrease. Increasing the length or resistivity of the lossy section can reduce the feedback of the oscillation to stabilize the amplifier. The W-band harmonic multiplying gyro-TWA is predicted to yield a peak output power of 111 kW at 98 GHz with an efficiency of 25%, a saturated gain of 26 dB, and a bandwidth of 1.6 GHz for a 60 kV, 7.5 A electron beam with an axial velocity spread of 8%.

Utilizing Team Debate to Increase Student Abilities for Mentoring and Critical Appraisal of Global Health Care in Doctor of Nursing Practice Programs.

Science.gov (United States)

Elliott, Naomi; Farnum, Karen; Beauchesne, Michelle

2016-01-01

Although graduates of doctor of nursing practice (DNP) programs are expected to demonstrate competence in advanced clinical scholarship, mentoring, and leadership, little is published about how team debate on a global health care topic supports DNP student learning and skill development. This article reports on an illuminative evaluation of DNP student learning experiences of team debate in the context of a 2-week international school program in Ireland. A focused illuminative evaluation approach involving a cohort of seven DNP students, who had participated in an international school team debate, was used. Data were collected using a Web-based qualitative questionnaire designed to elicit in-depth reflective accounts of DNP students' learning experiences. Content analysis revealed that team debate on a global health care topic enhanced learning in relation to fostering critical thinking and critical appraisal skills; encouraging teamwork; providing opportunities for mentoring, relationship building, and socialization into profession; and, from the DNP student perspective, increasing knowledge and global understanding of health care. This evaluation provides insights for nurse educators into the benefits of introducing team debate as a group activity to enhancing scholarly inquiry and mentoring skills of DNP students. Further research to evaluate team debate in other nurse education programs is needed. Copyright © 2016 Elsevier Inc. All rights reserved.

Low-Temperature Dynamic Nuclear Polarization at 9.4 Tesla With a 30 Milliwatt Microwave Source

Science.gov (United States)

Thurber, Kent R.; Yau, Wai-Ming; Tycko, Robert

2010-01-01

Dynamic nuclear polarization (DNP) can provide large signal enhancements in nuclear magnetic resonance (NMR) by transfer of polarization from electron spins to nuclear spins. We discuss several aspects of DNP experiments at 9.4 Tesla (400 MHz resonant frequency for 1H, 264 GHz for electron spins in organic radicals) in the 7–80 K temperature range, using a 30 mW, frequency-tunable microwave source and a quasi-optical microwave bridge for polarization control and low-loss microwave transmission. In experiments on frozen glycerol/water doped with nitroxide radicals, DNP signal enhancements up to a factor of 80 are observed (relative to 1H NMR signals with thermal equilibrium spin polarization). The largest sensitivity enhancements are observed with a new triradical dopant, DOTOPA-TEMPO. Field modulation with a 10 G root-mean-squared amplitude during DNP increases the nuclear spin polarizations by up to 135%. Dependencies of 1H NMR signal amplitudes, nuclear spin relaxation times, and DNP build-up times on the dopant and its concentration, temperature, microwave power, and modulation frequency are reported and discussed. The benefits of low-temperature DNP can be dramatic: the 1H spin polarization is increased approximately 1000-fold at 7 K with DNP, relative to thermal polarization at 80 K. PMID:20392658

Three-dimensional simulation of triode-type MIG for 1 MW, 120 GHz gyrotron for ECRH applications

Science.gov (United States)

Singh, Udaybir; Kumar, Nitin; Kumar, Narendra; Kumar, Anil; Sinha, A. K.

2012-01-01

In this paper, the three-dimensional simulation of triode-type magnetron injection gun (MIG) for 120 GHz, 1 MW gyrotron is presented. The operating voltages of the modulating anode and the accelerating anode are 57 kV and 80 kV respectively. The high order TE 22,6 mode is selected as the operating mode and the electron beam is launched at the first radial maxima for the fundamental beam-mode operation. The initial design is obtained by using the in-house developed code MIGSYN. The numerical simulation is performed by using the commercially available code CST-Particle Studio (PS). The simulated results of MIG obtained by using CST-PS are validated with other simulation codes EGUN and TRAK, respectively. The results on the design output parameters obtained by using these three codes are found to be in close agreement.

Numerical Design of Megawatt Gyrotron with 120 GHz Frequency and 50% Efficiency for Plasma Fusion Application

Science.gov (United States)

Kumar, Nitin; Singh, Udaybir; Kumar, Anil; Bhattacharya, Ranajoy; Singh, T. P.; Sinha, A. K.

2013-02-01

The design of 120 GHz, 1 MW gyrotron for plasma fusion application is presented in this paper. The mode selection is carried out considering the aim of minimum mode competition, minimum cavity wall heating, etc. On the basis of the selected operating mode, the interaction cavity design and beam-wave interaction computation are carried out by using the PIC code. The design of triode type Magnetron Injection Gun (MIG) is also presented. Trajectory code EGUN, synthesis code MIGSYN and data analysis code MIGANS are used in the MIG designing. Further, the design of MIG is also validated by using the another trajectory code TRAK. The design results of beam dumping system (collector) and RF window are also presented. Depressed collector is designed to enhance the overall tube efficiency. The design study confirms >1 MW output power with tube efficiency around 50% (with collector efficiency).

Design and testing of data analysis tool for ECRH systems in labview

International Nuclear Information System (INIS)

Patel, Jatinkumar; Patel, H.; Purohit, D.; Rajanbabu, N.; Mistry, H.; Shukla, B.K.

2017-01-01

Electron Cyclotron Resonance Heating (ECRH) is one of the essential RF heating sub systems used for pre-ionization and current drive experiments in SST1. In SST-1, Gyrotron based two ECRH systems are installed. 42 GHz gyrotron system capable of delivering 500kW RF power for 500ms and the 82.6 GHz gyrotron capable of delivering 200kW continuously for 1000 second. VME based Data acquisition and control (DAC) system is installed with the gyrotron systems and is under operation with SST-1. This paper explains the basic features of PXI DAC and the data analysis tool designed in labview 2014 and the problems faced during design and testing of different lengths of data plot. It has various features of plotting data in different categories i.e. plotting of fast acquisition signals data to decide the sequence of gyrotron interlocks happened during the gyrotron operations, conversion of main binary file into 32 .text files and all the 32 analog signals data plot in a single plot, auto update of selected important signals plot at the end of the shot

Backscattering of gyrotron radiation and short-wavelength turbulence during electron cyclotron resonance plasma heating in the L-2M stellarator

Energy Technology Data Exchange (ETDEWEB)

Batanov, G. M.; Borzosekov, V. D., E-mail: tinborz@gmail.com; Kovrizhnykh, L. M.; Kolik, L. V.; Konchekov, E. M.; Malakhov, D. V.; Petrov, A. E.; Sarksyan, K. A.; Skvortsova, N. N.; Stepakhin, V. D.; Kharchev, N. K. [Russian Academy of Sciences, Prokhorov General Physics Institute (Russian Federation)

2013-06-15

Backscattering of gyrotron radiation ({theta} = {pi}) by short-wavelength density fluctuations (k{sub Up-Tack} = 30 cm{sup -1}) in the plasma of the L-2M stellarator was studied under conditions of electron cyclotron resonance (ECR) plasma heating at the second harmonic of the electron gyrofrequency (75 GHz). The scattering of the O-wave emerging due to the splitting of the linearly polarized gyrotron radiation into the X- and O-waves was analyzed. The signal obtained after homodyne detection of scattered radiation is a result of interference of the reference signal, the quasi-steady component, and the fast oscillating component. The coefficients of reflection of the quasi-steady component, R{sub =}{sup 2}(Y), and fast oscillating component, R{sub {approx}}{sup 2}(Y), of scattered radiation are estimated. The growth of the R{sub {approx}}{sup 2}(Y) coefficient from 3.7 Multiplication-Sign 10{sup -4} to 5.2 Multiplication-Sign 10{sup -4} with increasing ECR heating power from 190 to 430 kW is found to correlate with the decrease in the energy lifetime from 1.9 to 1.46 ms. The relative density of short-wavelength fluctuations is estimated to be Left-Pointing-Angle-Bracket n{sub {approx}}{sup 2} Right-Pointing-Angle-Bracket / Left-Pointing-Angle-Bracket n{sub e}{sup 2} Right-Pointing-Angle-Bracket = 3 Multiplication-Sign 10{sup -7}. It is shown that the frequencies of short-wavelength fluctuations are in the range 10-150 kHz. The recorded short-wavelength fluctuations can be interpreted as structural turbulence, the energy of which comprises {approx}10% of the total fluctuations energy. Simulations of transport processes show that neoclassical heat fluxes are much smaller than anomalous ones. It is suggested that short-wavelength turbulence plays a decisive role in the anomalous heat transport.

Low-temperature dynamic nuclear polarization at 9.4 T with a 30 mW microwave source.

Science.gov (United States)

Thurber, Kent R; Yau, Wai-Ming; Tycko, Robert

2010-06-01

Dynamic nuclear polarization (DNP) can provide large signal enhancements in nuclear magnetic resonance (NMR) by transfer of polarization from electron spins to nuclear spins. We discuss several aspects of DNP experiments at 9.4 T (400 MHz resonant frequency for (1)H, 264 GHz for electron spins in organic radicals) in the 7-80K temperature range, using a 30 mW, frequency-tunable microwave source and a quasi-optical microwave bridge for polarization control and low-loss microwave transmission. In experiments on frozen glycerol/water doped with nitroxide radicals, DNP signal enhancements up to a factor of 80 are observed (relative to (1)H NMR signals with thermal equilibrium spin polarization). The largest sensitivity enhancements are observed with a new triradical dopant, DOTOPA-TEMPO. Field modulation with a 10 G root-mean-squared amplitude during DNP increases the nuclear spin polarizations by up to 135%. Dependencies of (1)H NMR signal amplitudes, nuclear spin relaxation times, and DNP build-up times on the dopant and its concentration, temperature, microwave power, and modulation frequency are reported and discussed. The benefits of low-temperature DNP can be dramatic: the (1)H spin polarization is increased approximately 1000-fold at 7 K with DNP, relative to thermal polarization at 80K. (c) 2010 Elsevier Inc. All rights reserved.

Maturing ECRF technology for plasma control

International Nuclear Information System (INIS)

Callis, R.W.; .; Cary, W.P.; Chu, S.

2003-01-01

The availability of high power, (∼1 MW) long pulse length (effectively cw), high frequency, (>100 GHz) gyrotrons has opened the opportunity for enhanced scientific results on magnetic confinement devices for fusion research worldwide. This has led to successful experiments on electron cyclotron heating, electron cyclotron current drive, non-inductive tokamak operation, tokamak energy transport, suppression of instabilities and advanced profile control leading to enhanced performance. The key development in the gyrotron community that has led to the realization of high power long pulse gyrotrons is the availability of edge cooled synthetic diamond gyrotron output windows, which have low loss and excellent thermal and mechanical properties. In addition to the emergence of reliable high power gyrotrons, ancillary equipment for efficient microwave transmission over distances of hundreds of meters, polarization control, diagnostics, and flexible launch geometry have all been developed and proven in regular service. (author)

Precision Characterization of Gyrotron Window Materials

Energy Technology Data Exchange (ETDEWEB)

Jones, Charles R. [North Carolina Central Univ., Durham, NC (United States)

2012-12-31

utilize this material to solve the challenging problems that are encountered as devices are pushed to operate at higher frequencies and higher power levels. In particular, for the fusion energy program, it may provide an economical alternative to CVD diamond for certain gyrotron and beam line applications. In addition, the value obtained for the Debye temperature provides an important datum for modeling the crystalline structure of SiC. Clearly SiC is a unique material with few competitors and should see wider utilization.

A versatile and modular quasi optics-based 200 GHz dual dynamic nuclear polarization and electron paramagnetic resonance instrument

Science.gov (United States)

Siaw, Ting Ann; Leavesley, Alisa; Lund, Alicia; Kaminker, Ilia; Han, Songi

2016-03-01

Solid-state dynamic nuclear polarization (DNP) at higher magnetic fields (>3 T) and cryogenic temperatures (∼2-90 K) has gained enormous interest and seen major technological advances as an NMR signal enhancing technique. Still, the current state of the art DNP operation is not at a state at which sample and freezing conditions can be rationally chosen and the DNP performance predicted a priori, but relies on purely empirical approaches. An important step towards rational optimization of DNP conditions is to have access to DNP instrumental capabilities to diagnose DNP performance and elucidate DNP mechanisms. The desired diagnoses include the measurement of the "DNP power curve", i.e. the microwave (MW) power dependence of DNP enhancement, the "DNP spectrum", i.e. the MW frequency dependence of DNP enhancement, the electron paramagnetic resonance (EPR) spectrum, and the saturation and spectral diffusion properties of the EPR spectrum upon prolonged MW irradiation typical of continuous wave (CW) DNP, as well as various electron and nuclear spin relaxation parameters. Even basic measurements of these DNP parameters require versatile instrumentation at high magnetic fields not commercially available to date. In this article, we describe the detailed design of such a DNP instrument, powered by a solid-state MW source that is tunable between 193 and 201 GHz and outputs up to 140 mW of MW power. The quality and pathway of the transmitted and reflected MWs is controlled by a quasi-optics (QO) bridge and a corrugated waveguide, where the latter couples the MW from an open-space QO bridge to the sample located inside the superconducting magnet and vice versa. Crucially, the versatility of the solid-state MW source enables the automated acquisition of frequency swept DNP spectra, DNP power curves, the diagnosis of MW power and transmission, and frequency swept continuous wave (CW) and pulsed EPR experiments. The flexibility of the DNP instrument centered around the QO MW

A versatile and modular quasi optics-based 200GHz dual dynamic nuclear polarization and electron paramagnetic resonance instrument.

Science.gov (United States)

Siaw, Ting Ann; Leavesley, Alisa; Lund, Alicia; Kaminker, Ilia; Han, Songi

2016-03-01

Solid-state dynamic nuclear polarization (DNP) at higher magnetic fields (>3T) and cryogenic temperatures (∼ 2-90K) has gained enormous interest and seen major technological advances as an NMR signal enhancing technique. Still, the current state of the art DNP operation is not at a state at which sample and freezing conditions can be rationally chosen and the DNP performance predicted a priori, but relies on purely empirical approaches. An important step towards rational optimization of DNP conditions is to have access to DNP instrumental capabilities to diagnose DNP performance and elucidate DNP mechanisms. The desired diagnoses include the measurement of the "DNP power curve", i.e. the microwave (MW) power dependence of DNP enhancement, the "DNP spectrum", i.e. the MW frequency dependence of DNP enhancement, the electron paramagnetic resonance (EPR) spectrum, and the saturation and spectral diffusion properties of the EPR spectrum upon prolonged MW irradiation typical of continuous wave (CW) DNP, as well as various electron and nuclear spin relaxation parameters. Even basic measurements of these DNP parameters require versatile instrumentation at high magnetic fields not commercially available to date. In this article, we describe the detailed design of such a DNP instrument, powered by a solid-state MW source that is tunable between 193 and 201 GHz and outputs up to 140 mW of MW power. The quality and pathway of the transmitted and reflected MWs is controlled by a quasi-optics (QO) bridge and a corrugated waveguide, where the latter couples the MW from an open-space QO bridge to the sample located inside the superconducting magnet and vice versa. Crucially, the versatility of the solid-state MW source enables the automated acquisition of frequency swept DNP spectra, DNP power curves, the diagnosis of MW power and transmission, and frequency swept continuous wave (CW) and pulsed EPR experiments. The flexibility of the DNP instrument centered around the QO MW

Status of the new multi-frequency ECRH system for ASDEX Upgrade

DEFF Research Database (Denmark)

Wagner, D.; Grünwald, G.; Leuterer, F.

2008-01-01

Currently, a new multi-frequency ECRH system is under construction at the ASDEX Upgrade tokamak experiment. This system employs, for the first time in a fusion device, multi-frequency gyrotrons, step-tunable in the range 105-140 GHz. The first two gyrotrons, working at 105 and 140 GHz, were...

The DIII-D 3 MW, 110 GHz ECH System

International Nuclear Information System (INIS)

Callis, R.W.; Lohr, J.; Ponce, D.; O'Neill, R.C.; Prater, R.; Luce, T.C.

1999-01-01

Three 110 GHz gyrotrons with nominal output power of 1 MW each have been installed and are operational on the DIII-D tokamak. One gyrotron is built by Gycom and has a nominal rating of 1 MW and a 2 s pulse length, with the pulse length being determined by the maximum temperature allowed on the edge cooled Boron Nitride window. The second and third gyrotrons were built by Communications and Power Industries (CPI). The first CPI gyrotron uses a double disc FC-75 cooled sapphire window which has a pulse length rating of 0.8 s at 1 MW, 2s at 0.5 MW and 10s at 0.35 MW. The second CPI gyrotron, utilizes a single disc chemical-vapor-deposition diamond window, that employs water cooling around the edge of the disc. Calculation predict that the diamond window should be capable of full 1 MW cw operation. All gyrotrons are connected to the tokamak by a low-loss-windowless evacuated transmission line using circular corrugated waveguide for propagation in the HEl 1 mode. Each waveguide system incorporates a two mirror launcher which can steer the rf beam poloidally from the center to the outer edge of the plasma. Central current drive experiments with the two gyrotrons with 1.5 MW of injected power drove about 0.17 MA. Results from using the three gyrotron systems will be reported as well as the plans to upgrade the system to 6 MW

Design and fabrication of circular and rectangular components for electron-cyclotron-resonant heating of tandem mirror experiment-upgrade

International Nuclear Information System (INIS)

Felker, B.; Calderon, M.O.; Chargin, A.K.

1983-01-01

The electron-cyclotron-resonant heating (ECRH) systems of rectangular waveguides on Tandem Mirror Experiment-Upgrade (TMX-U) operated with a overall efficiency of 50%, each system using a 28-GHz, 200-kW pulsed gyrotron. We designed and built four circular-waveguide systems with greater efficiency and greater power-handling capabilities to replace the rectangular waveguides. Two of these circular systems, at the 5-kG second-harmonic heating locations, have a total transmission efficiency of >90%. The two systems at the 10-kG fundamental heating locations have a total transmission efficiency of 80%. The difference in efficiency is due to the additional components required to launch the microwaves in the desired orientation and polarization with respect to magnetic-field lines at the 10-kG points. These systems handle the total power available from each gyrotron but do not have the arcing limitation problem of the rectangular waveguide. Each system requires several complex components. The overall physical layout and the design considerations for the rectangular and circular waveguide components are described here

Design and fabrication of circular and rectangular components for electron-cyclotron-resonant heating of tandem mirror experiment-upgrade

Energy Technology Data Exchange (ETDEWEB)

Felker, B.; Calderon, M.O.; Chargin, A.K.; Coffield, F.E.; Lang, D.D.; Rubert, R.R.; Pedrotti, L.R.; Stallard, B.W.; Gallagher, N.C. Jr.; Sweeney, D.W.

1983-11-18

The electron-cyclotron-resonant heating (ECRH) systems of rectangular waveguides on Tandem Mirror Experiment-Upgrade (TMX-U) operated with a overall efficiency of 50%, each system using a 28-GHz, 200-kW pulsed gyrotron. We designed and built four circular-waveguide systems with greater efficiency and greater power-handling capabilities to replace the rectangular waveguides. Two of these circular systems, at the 5-kG second-harmonic heating locations, have a total transmission efficiency of >90%. The two systems at the 10-kG fundamental heating locations have a total transmission efficiency of 80%. The difference in efficiency is due to the additional components required to launch the microwaves in the desired orientation and polarization with respect to magnetic-field lines at the 10-kG points. These systems handle the total power available from each gyrotron but do not have the arcing limitation problem of the rectangular waveguide. Each system requires several complex components. The overall physical layout and the design considerations for the rectangular and circular waveguide components are described here.

Progress on Electron Cyclotron Heating Experiments in LHD

International Nuclear Information System (INIS)

Shimozuma, T.; Kubo, S.; Yoshimura, Y.; Igami, H.; Nagasaki, K.; Notake, T.; Inagaki, S.; Ito, S.; Kobayashi, S.; Mizuno, Y.; Takita, Y.; Ohkubo, K.; Saito, K.; Seki, T.; Kumazawa, R.; Watari, T.; Mutoh, T.

2005-01-01

Electron cyclotron resonance heating (ECH) is a powerful heating method because of its well-controlled local heating and high deposition power density. Together with the development of high power long pulse gyrotrons, ECH becomes one of the major heating scenarios to control electron temperature and current profiles for the improved plasma confinement and suppression of some magneto-hydro-dainamic (MHD) instabilities in both tokamaks and stellarators [1]. In the Large Helical Device (LHD), ECH has been worked as a method of plasma initiation and electron heating. The ECH system has been improved with respect to each experimental campaign. In the recent campaign, nine gyrotrons were operated reliably and steadily. As a diagnostic objective, a modulated ECH (MECH) was injected together with main ECH power. A Fourier analysis of the induced heat wave gave useful information of not only the heat transport in the plasmas but also precise power deposition layer [2]. Several kinds of ECH experiment were performed by using this flexible ECH system. In LHD, electron ITB formation have been observed by using strongly focused ECH in the plasma core [3].Two different kinds of improved confinement were realized depending on the direction of tangentially injected NBI. NBI beam driven currents modify the profiles of the rotational transform 2 ro and the existence low order rational surfaces, 2 = 0.5 in special, affects the difference of appearance of the improved confinement states. The MECH method was used to investigate the internal structure of the thermal diffusion in such plasmas [4]. Another important role of the MECH is the precise determination of the ECH power deposition. Shift of the deposition location by changing an injection polarization in the electron Bernstein wave (EBW) heating was clearly demonstrated by the MECH method. Electron cyclotron current drive (ECCD) experiments were proceeded by using a flexible antenna system, which had wide scanning range in both

Using implementation science as the core of the doctor of nursing practice inquiry project.

Science.gov (United States)

Riner, Mary E

2015-01-01

New knowledge in health care needs to be implemented for continuous practice improvement. Doctor of nursing practice (DNP) programs are designed to increase clinical practice knowledge and leadership skills of graduates. This article describes an implementation science course developed in a DNP program focused on advancing graduates' capacity for health systems leadership. Curriculum and course development are presented, and the course is mapped to depict how the course objectives and assignments were aligned with DNP Essentials. Course modules with rational are described, and examples of how students implemented assignments are provided. The challenges of integrating this course into the life of the school are discussed as well as steps taken to develop faculty for this capstone learning experience. This article describes a model of using implementation science to provide DNP students an experience in designing and managing an evidence-based practice change project. Copyright © 2015 Elsevier Inc. All rights reserved.

60 GHz gyrotron development program. Final report, April 1979-June 1984

International Nuclear Information System (INIS)

Shively, J.F.; Bier, R.E.; Caplan, M.

1986-01-01

The original objective of this program was to develop a microwave amplifier or oscillator capable of producing 200 kW CW power output at 110 GHz. The use of cyclotron resonance interaction was pursued, and the design phases of this effort are discussed. Later, however, the program's objective was changed to develop a family of oscillators capable of producing 200 kw of peak output power at 60 GHz. Gyrotron behavior studies were performed at 28 GHz to obtain generic design information as quickly as possible. The first experimental device at 60 GHz produced over 200 kw of peak power at a pulse duration of 20 μs. Heating problems and mode interference were encountered. The second experimental tube incorporated an optimized gun location but also suffered from mode interference. The third experimental tube included modifications that reduced mode interference. It demonstrated 200 kw of peak output at 100 ms pulse duration. The fourth experimental tube, which used an older rf circuit design but in a CW configuration, produced 71.5 kW CW. The fifth experimental tube incorporated a thinner double-disc output window which improved window bandwidth and reduced window loss. This tube also incorporated modifications to the drift tunnel and cavity coupling, which had proven successful in the third experimental pulse tube tests. It produced 123 kW of CW output power at 60 GHz rf load coolant boiling and tube window failure terminated the tests. A new waterload was designed and constructed, and alternative window designs were explored

Mechanisms of amplification of ultrashort electromagnetic pulses in gyrotron traveling wave tube with helically corrugated waveguide

International Nuclear Information System (INIS)

Ginzburg, N. S.; Zaslavsky, V. Yu.; Zotova, I. V.; Sergeev, A. S.; Zheleznov, I. V.; Samsonov, S. V.; Mishakin, S. V.

2015-01-01

A time-domain self consistent theory of a gyrotron traveling wave tube with a helically corrugated operating waveguide has been developed. Based on this model, the process of short pulse amplification was studied in regimes of grazing and intersection of the dispersion curves of the electromagnetic wave and the electron beam. In the first case, the possibility of amplification without pulse form distortion was demonstrated for the pulse spectrum width of the order of the gain bandwidth. In the second case, when the electrons' axial velocity was smaller than the wave's group velocity, it was shown that the slippage of the incident signal with respect to the electron beam provides feeding of the signal by “fresh” electrons without initial modulation. As a result, the amplitude of the output pulse can exceed the amplitude of its saturated value for the case of the grazing regime, and, for optimal parameters, the peak output power can be even larger than the kinetic power of the electron beam

Three-wave interaction during electron cyclotron resonance heating and current drive

DEFF Research Database (Denmark)

Nielsen, Stefan Kragh; Jacobsen, Asger Schou; Hansen, Søren Kjer

2016-01-01

Non-linear wave-wave interactions in fusion plasmas, such as the parametric decay instability (PDI) of gyrotron radiation, can potentially hamper the use of microwave diagnostics. Here we report on anomalous scattering in the ASDEX Upgrade tokamak during electron cyclotron resonance heating...... experiments. The observations can be linked to parametric decay of the gyrotron radiation at the second harmonic upper hybrid resonance layer....

Stabilization of the potential multi-steady-state absolute instabilities in a gyrotron traveling-wave amplifier

International Nuclear Information System (INIS)

Du Chaohai; Liu Pukun

2009-01-01

The problem of spurious oscillations induced by absolute instabilities is the most challenging one that hinders the development of the millimeter-wave gyrotron traveling-wave amplifiers (gyro-TWTs). A spurious oscillation exists as a high order axial mode (HOAM) in the interaction circuit. This paper is devoted to demonstrating the complicated steady states of these HOAMs and exploring corresponding techniques to stabilize these potential multi-steady-state absolute instabilities. The stability-oriented design principle is conveyed in a start-to-end design flow of a Ka-band TE 11 mode gyro-TWT. Strong magnetic tapering near the downstream port, which is capable of cutting short the effective interaction circuit of a spurious oscillation and simultaneously boosting the amplification performance, is for the first time proposed to further improve the system stability. It is also found that an ideal prebunched electron beam in the linear stage is the necessary condition to efficient amplification in the nonlinear stage, suggesting that it is feasible to design a stable prebunching stage to replace the distributed-loss-loaded linear stage. The stability-oriented design principle provides more explicit reference for future design of a zero-drive stable gyro-TWT.

FY92 Progress Report for the Gyrotron Backward-Wave-Oscillator Experiment

Science.gov (United States)

1993-07-01

C. SAMPLE CABLE CALIBRATION 23 D. ASYST CHANNEL SETUPS 26 E. SAMPLE MAGNET INPUT DATA DECK FOR THE GYRO-BWO 32 F. SAMPLE EGUN INPUT DATA DECK FOR THE...of the first coil of the Helmholtz pair; zero also corresponds to the diode end of the experiment). Another computer code used was the EGUN code (Ref...a short computer program was written to superimpose the two magnetic fields; DC and Helmholtz). An example of an EGUN input data file is included in

Dynamic nuclear polarization of nucleic acid with endogenously bound manganese

International Nuclear Information System (INIS)

Wenk, Patricia; Kaushik, Monu; Richter, Diane; Vogel, Marc; Suess, Beatrix; Corzilius, Björn

2015-01-01

We report the direct dynamic nuclear polarization (DNP) of 13 C nuclei of a uniformly [ 13 C, 15 N]-labeled, paramagnetic full-length hammerhead ribozyme (HHRz) complex with Mn 2+ where the enhanced polarization is fully provided by the endogenously bound metal ion and no exogenous polarizing agent is added. A 13 C enhancement factor of ε = 8 was observed by intra-complex DNP at 9.4 T. In contrast, “conventional” indirect and direct DNP experiments were performed using AMUPol as polarizing agent where we obtained a 1 H enhancement factor of ε ≈ 250. Comparison with the diamagnetic (Mg 2+ ) HHRz complex shows that the presence of Mn 2+ only marginally influences the (DNP-enhanced) NMR properties of the RNA. Furthermore two-dimensional correlation spectra ( 15 N– 13 C and 13 C– 13 C) reveal structural inhomogeneity in the frozen, amorphous state indicating the coexistence of several conformational states. These demonstrations of intra-complex DNP using an endogenous metal ion as well as DNP-enhanced MAS NMR of RNA in general yield important information for the development of new methods in structural biology

UTAUT2 Based Predictions of Factors Influencing the Technology Acceptance of Phablets by DNP

Directory of Open Access Journals (Sweden)

Chi-Yo Huang

2015-01-01

Full Text Available The smart mobile devices have emerged during the past decade and have become one of the most dominant consumer electronic products. Therefore, exploring and understanding the factors which can influence the acceptance of novel mobile technology have become the essential task for the vendors and distributors of mobile devices. The Phablets, integrated smart devices combining the functionality and characteristics of both tablet PCs and smart phones, have gradually become possible alternatives for smart phones. Therefore, predicting factors which can influence the acceptance of Phablets have become indispensable for designing, manufacturing, and marketing of such mobile devices. However, such predictions are not easy. Meanwhile, very few researches tried to study related issues. Consequently, the authors aim to explore and predict the intentions to use and use behaviors of Phablets. The second generation of the Unified Theory of Acceptance and Use of Technology (UTAUT2 is introduced as a theoretic basis. The Decision Making Trial and Evaluation Laboratory (DEMATEL based Network Process (DNP will be used to construct the analytic framework. In light of the analytic results, the causal relationships being derived by the DEMATEL demonstrate the direct influence of the habit on other dimensions. Also, based on the influence weights being derived, the use intention, hedonic motivation, and performance expectancy are the most important dimensions. The analytic results can serve as a basis for concept developments, marketing strategy definitions, and new product designs of the future Phablets. The proposed analytic framework can also be used for predicting and analyzing consumers’ preferences toward future mobile devices.

Power systems for the Doublet III 2-MW ECH system

International Nuclear Information System (INIS)

Remsen, D.B. Jr.

1981-10-01

A system providing 5 second pulses at 60 GHz from ten 200 kW gyrotrons is being prepared for electron cyclotron heating experiments on Doublet III. The power supply for the gyrotron system is a power supply currently under construction by Universal Voltronics Corporation for the Doublet III neutral beam power supply, and is to have the option of reverse polarity (negative) to fill the needs of the system of ten gyrotons operating in parallel. The output of this power supply is 80 kV at 100A for 5 second pulses with good regulation. The output pulse rise and fall times and fault protection response time are all compatible with the gyrotron requirements

The Compact Ignition Tokamak and electron cyclotron heating: Description of need; assessment of prospects

International Nuclear Information System (INIS)

Ignat, D.W.; Cohn, D.R.; Woskov, P.P.

1989-01-01

The CIT will benefit from auxiliary heating of 10 to 40 MW. The schedules of both the CIT construction project and the operating plan contain adequate time to develop and implement ECH systems based on the gyrotron and the induction free electron laser (IFEL). Each approach has advantages and is the object of R and D at the level of many millions of dollars per year. While the gyrotron is further advanced in terms of power and pulse length achieved, rapid progress is scheduled for the IFEL, including experiments on tokamaks. Plans of CIT, gyrotron, and IFEL make 1992 an appropriate time frame to commit to one or both systems. 12 refs., 8 figs., 2 tabs

Dynamic nuclear polarization for magnetic resonance imaging. An in-bore approach

Energy Technology Data Exchange (ETDEWEB)

Krummenacker, Jan G.

2012-07-01

In this thesis, the development of an in-bore liquid state DNP polarizer for MRI applications operating in flow through mode at a magnetic field strength of 1.5 T was described. After an introductory chapter 1 and a chapter 2 on the theoretical background, chapter 3 dealt chiefly with the challenge of performing liquid state DNP at a high magnetic field of 9.2 T. The feasibility of performing liquid state DNP at this field was demonstrated for various solvents, as well as for metabolites in solution. Chapter 4 then moved to the aim of this work, the application of liquid state DNP for MRI experiments. It introduced the rationale of our approach, the hardware that was developed and demonstrated its performance in a clinical MRI tomograph.

Dynamic nuclear polarization for magnetic resonance imaging. An in-bore approach

International Nuclear Information System (INIS)

Krummenacker, Jan G.

2012-01-01

In this thesis, the development of an in-bore liquid state DNP polarizer for MRI applications operating in flow through mode at a magnetic field strength of 1.5 T was described. After an introductory chapter 1 and a chapter 2 on the theoretical background, chapter 3 dealt chiefly with the challenge of performing liquid state DNP at a high magnetic field of 9.2 T. The feasibility of performing liquid state DNP at this field was demonstrated for various solvents, as well as for metabolites in solution. Chapter 4 then moved to the aim of this work, the application of liquid state DNP for MRI experiments. It introduced the rationale of our approach, the hardware that was developed and demonstrated its performance in a clinical MRI tomograph.

First feedback with the AMMON integral experiment for the JHR calculations

Directory of Open Access Journals (Sweden)

Lemaire M.

2013-03-01

Full Text Available The innovative design of the next international Material Testing Reactor, the Jules Horowitz Reactor (JHR, induced the development of a new neutron and photon calculation formular HORUS3D/P&N, based on deterministic and stochastic codes and the European nuclear data library JEFF3.1.1. A new integral experiment, named the AMMON experiment, was designed in order to make the experimental validation of HORUS3D. The objectives of this experimental program are to calibrate the biases and uncertainties associated with the HORUS3D/N&P calculations for JHR safety and design calculations, but also the validation of some specific nuclear data (concerning mainly hafnium and beryllium isotopes. The experiment began in 2010 and is currently performed in the EOLE zero-power critical mock-up at CEA Cadarache. This paper deals with the first feedback of the AMMON experiments with 3D Monte Carlo TRIPOLI4©/JEFF3.1.1 calculations.

Dynamic nuclear polarization of nucleic acid with endogenously bound manganese

Energy Technology Data Exchange (ETDEWEB)

Wenk, Patricia [University of Tübingen, Werner Siemens Imaging Center and Department of Preclinical Imaging and Radiopharmacy (Germany); Kaushik, Monu; Richter, Diane [Goethe University, Institute of Physical und Theoretical Chemistry, Institute of Biophysical Chemistry und Center for Biomolecular Magnetic Resonance (BMRZ) (Germany); Vogel, Marc; Suess, Beatrix [Technical University Darmstadt, Department of Biology (Germany); Corzilius, Björn, E-mail: corzilius@em.uni-frankfurt.de [Goethe University, Institute of Physical und Theoretical Chemistry, Institute of Biophysical Chemistry und Center for Biomolecular Magnetic Resonance (BMRZ) (Germany)

2015-09-15

We report the direct dynamic nuclear polarization (DNP) of {sup 13}C nuclei of a uniformly [{sup 13}C,{sup 15}N]-labeled, paramagnetic full-length hammerhead ribozyme (HHRz) complex with Mn{sup 2+} where the enhanced polarization is fully provided by the endogenously bound metal ion and no exogenous polarizing agent is added. A {sup 13}C enhancement factor of ε = 8 was observed by intra-complex DNP at 9.4 T. In contrast, “conventional” indirect and direct DNP experiments were performed using AMUPol as polarizing agent where we obtained a {sup 1}H enhancement factor of ε ≈ 250. Comparison with the diamagnetic (Mg{sup 2+}) HHRz complex shows that the presence of Mn{sup 2+} only marginally influences the (DNP-enhanced) NMR properties of the RNA. Furthermore two-dimensional correlation spectra ({sup 15}N–{sup 13}C and {sup 13}C–{sup 13}C) reveal structural inhomogeneity in the frozen, amorphous state indicating the coexistence of several conformational states. These demonstrations of intra-complex DNP using an endogenous metal ion as well as DNP-enhanced MAS NMR of RNA in general yield important information for the development of new methods in structural biology.

Design of the ITER Electron Cyclotron Heating and Current Drive Waveguide Transmission Line

Science.gov (United States)

Bigelow, T. S.; Rasmussen, D. A.; Shapiro, M. A.; Sirigiri, J. R.; Temkin, R. J.; Grunloh, H.; Koliner, J.

2007-11-01

The ITER ECH transmission line system is designed to deliver the power, from twenty-four 1 MW 170 GHz gyrotrons and three 1 MW 127.5 GHz gyrotrons, to the equatorial and upper launchers. The performance requirements, initial design of components and layout between the gyrotrons and the launchers is underway. Similar 63.5 mm ID corrugated waveguide systems have been built and installed on several fusion experiments; however, none have operated at the high frequency and long-pulse required for ITER. Prototype components are being tested at low power to estimate ohmic and mode conversion losses. In order to develop and qualify the ITER components prior to procurement of the full set of 24 transmission lines, a 170 GHz high power test of a complete prototype transmission line is planned. Testing of the transmission line at 1-2 MW can be performed with a modest power (˜0.5 MW) tube with a low loss (10-20%) resonant ring configuration. A 140 GHz long pulse, 400 kW gyrotron will be used in the initial tests and a 170 GHz gyrotron will be used when it becomes available. Oak Ridge National Laboratory, managed by UT-Battelle, LLC, for the U.S. Dept. of Energy under contract DE-AC05-00OR22725.

The effect of motion on dynamic nuclear polarization: A new theoretical development

International Nuclear Information System (INIS)

Coffino, A.R.

1989-01-01

Dynamic Nuclear Polarization (DNP) is a magnetic resonance technique which uses two different radiation sources: a radiofrequency field and microwave field to radiate nuclei and electrons, respectively. The DNP experiment probes the nature of the interaction between nuclei and electrons. The maximum of the resonance signal from the nucleus is plotted as a function of microwave frequency for the case of the microwaves on and off. The DNP signal is the ratio of these two signals and is termed the enhancement of the nuclear signal. This thesis considers the theory of the DNP signal based on the density matrix formulation of the Stochastic Liouville Equation, which incorporates the spin-spin interactions, spin-field interactions and a stochastic dynamics process which modulates these interactions. The case of one electron coupled to one spin one-half nucleus is considered. Such a formulation has never been developed. The thesis demonstrates that previous partial theories have attempted to incorporate dynamics have been incorrect. This theoretical development demonstrates, for the first time, how dynamics affects the DNP lineshapes. This theory predicts that DNP spectra change smoothly from the no motion to the fast motion region, and reproduces the known analytic answers in both the no-motion and the fast-motion limit. The most important observation of the results is that a DNP signal for a motional rate in the intermediate motional region looks like a superposition of a no-motion and fast-motion signal

High power rf amplifiers for accelerator applications: The large orbit gyrotron and the high current, space charge enhanced relativistic klystron

International Nuclear Information System (INIS)

Stringfield, R.M.; Fazio, M.V.; Rickel, D.G.; Kwan, T.J.T.; Peratt, A.L.; Kinross-Wright, J.; Van Haaften, F.W.; Hoeberling, R.F.; Faehl, R.; Carlsten, B.; Destler, W.W.; Warner, L.B.

1991-01-01

Los Alamos is investigating a number of high power microwave (HPM) sources for their potential to power advanced accelerators. Included in this investigation are the large orbit gyrotron amplifier and oscillator (LOG) and the relativistic klystron amplifier (RKA). LOG amplifier development is newly underway. Electron beam power levels of 3 GW, 70 ns duration, are planned, with anticipated conversion efficiencies into RF on the order of 20 percent. Ongoing investigations on this device include experimental improvement of the electron beam optics (to allow injection of a suitable fraction of the electron beam born in the gun into the amplifier structure), and computational studies of resonator design and RF extraction. Recent RKA studies have operated at electron beam powers into the device of 1.35 GW in microsecond duration pulses. The device has yielded modulated electron beam power approaching 300 MW using 3-5 kW of RF input drive. RF powers extracted into waveguide have been up to 70 MW, suggesting that more power is available from the device than has been converted to-date in the extractor

Plans for improvements to the ATF ECH system

International Nuclear Information System (INIS)

Bigelow, T.S.; Goldfinger, R.C.; Murakami, M.; Schaich, C.R.; Wilgen, J.B.

1993-01-01

The Advanced Toroidal Facility (ATF) stellarator experiment at Oak Ridge National Laboratory (ORNL) uses electron cyclotron waves for plasma formation and heating. Although the existing systems are quite reliable and produce acceptable plasmas, a few deficiencies should be corrected. Therefore, several possible upgrades to the electron cyclotron heating (ECH) systems have been planned. Some of the desirable changes are (1) improving the launcher to make power deposition in the plasma more centralized, (2) improving the gyrotron power waveform monitoring diagnostics, (3) building a high-field launch system for higher density operation at 53-GHz (4) building a separate transmission line for the 35-GHz gyrotron, and (5) installing a higher frequency, higher power (84- or 110-GHz) gyrotron system for improved plasma density and temperature capability. This paper discusses options for these improvements and conceptual designs. (orig.)

Environmental conditions influence the plant functional diversity effect on potential denitrification.

Directory of Open Access Journals (Sweden)

Ariana E Sutton-Grier

2011-02-01

Full Text Available Global biodiversity loss has prompted research on the relationship between species diversity and ecosystem functioning. Few studies have examined how plant diversity impacts belowground processes; even fewer have examined how varying resource levels can influence the effect of plant diversity on microbial activity. In a field experiment in a restored wetland, we examined the role of plant trait diversity (or functional diversity, (FD and its interactions with natural levels of variability of soil properties, on a microbial process, denitrification potential (DNP. We demonstrated that FD significantly affected microbial DNP through its interactions with soil conditions; increasing FD led to increased DNP but mainly at higher levels of soil resources. Our results suggest that the effect of species diversity on ecosystem functioning may depend on environmental factors such as resource availability. Future biodiversity experiments should examine how natural levels of environmental variability impact the importance of biodiversity to ecosystem functioning.

Solid Polarized Targets and Applications

International Nuclear Information System (INIS)

Crabb, D. G.

2008-01-01

Examples are given of dynamically polarized targets in use today and how the subsystems have changed to meet the needs of todays experiments. Particular emphasis is placed on target materials such as ammonia and lithium deuteride. Recent polarization studies of irradiated materials such as butanol, deuterated butanol, polyethylene, and deuterated polyethylene are presented. The operation of two non-DNP target systems as well as applications of traditional DNP targets are briefly discussed

Observation of dynamic interactions between fundamental and second-harmonic modes in a high-power sub-terahertz gyrotron operating in regimes of soft and hard self-excitation.

Science.gov (United States)

Saito, Teruo; Tatematsu, Yoshinori; Yamaguchi, Yuusuke; Ikeuchi, Shinji; Ogasawara, Shinya; Yamada, Naoki; Ikeda, Ryosuke; Ogawa, Isamu; Idehara, Toshitaka

2012-10-12

Dynamic mode interaction between fundamental and second-harmonic modes has been observed in high-power sub-terahertz gyrotrons [T. Notake et al., Phys. Rev. Lett. 103, 225002 (2009); T. Saito et al. Phys. Plasmas 19, 063106 (2012)]. Interaction takes place between a parasitic fundamental or first-harmonic (FH) mode and an operating second-harmonic (SH) mode, as well as among SH modes. In particular, nonlinear excitation of the parasitic FH mode in the hard self-excitation regime with assistance of a SH mode in the soft self-excitation regime was clearly observed. Moreover, both cases of stable two-mode oscillation and oscillation of the FH mode only were observed. These observations and theoretical analyses of the dynamic behavior of the mode interaction verify the nonlinear hard self-excitation of the FH mode.

Comparison between the electron cyclotron current drive experiments on DIII-D and predictions for T-10

International Nuclear Information System (INIS)

Lohr, J.; Harvey, R.W.; Luce, T.C.; Matsuda, Kyoko; Moeller, C.P.; Petty, C.C.; Prater, R.; James, R.A.; Giruzzi, G.; Gorelov, Y.; DeHaas, J.

1990-11-01

Electron cyclotron current drive has been demonstrated on the DIII-D tokamak in an experiment in which ∼1 MW of microwave power generated ∼50 kA of non-inductive current. The rf-generated portion was about 15% of the total current. On the T-10 tokamak, more than 3 MW of microwave power will be available for current generation, providing the possibility that all the plasma current could be maintained by this method. Fokker-Planck calculations using the code CQL3D and ray tracing calculations using TORAY have been performed to model both experiments. For DIII-D the agreement between the calculations and measurements is good, producing confidence in the validity of the computational models. The same calculations using the T-10 geometry predict that for n e (0) ∼ 1.8 x 10 13 cm -3 , and T e (0) ∼ 7 keV, 1.2 MW, that is, the power available from only three gyrotrons, could generate as much as 150 kA of non-inductive current. Parameter space scans in which temperature, density and resonance location were varied have been performed to indicate the current drive expected under different experimental conditions. The residual dc electric field was considered in the DIII-D analysis because of its nonlinear effect on the electron distribution, which complicates the interpretation of the results. A 110 GHz ECH system is being installed on DIII-D. Initial operations, planned for late 1991, will use four gyrotrons with 500 kW each and 10 second output pulses. Injection will be from the low field side from launchers which can be steered to heat at the desired location. These launchers, two of which are presently installed, are set at 20 degrees to the radial and rf current drive studies are planned for the initial operation. 8 refs., 10 figs

The Doctor of Nursing Practice: defining the next steps.

Science.gov (United States)

Grey, Margaret

2013-08-01

The purpose of this article is to summarize the previous articles in this special issue of the Journal of Nursing Education that are based on the Committee on Institutional Cooperation's Dean's Conference on the Doctor of Nursing Practice (DNP) and to identify areas of consensus, as well as areas of controversy. Areas of consensus include the high level of interest in DNP programs and the intent to expand the role of the advanced practice nurse to population health, policy, and leadership. Areas of controversy include the nature of the DNP product, the definition of clinical experiences, the nature of the capstone project, the outcomes of these new practitioners, and the impact on schools. Suggestions for achieving higher levels of consensus, including the need for respective, inclusive dialogue, are provided. Copyright 2013, SLACK Incorporated.

State-of-the-art of high power gyro-devices and free electron masers. Update 2015

Energy Technology Data Exchange (ETDEWEB)

Thumm, Manfred [Karlsruher Institut fuer Technologie (KIT), Eggenstein-Leopoldshafen (Germany). Inst. fuer Hochleistungsimpuls- und Mikrowellentechnik, Programm Fusion

2016-07-01

Gyrotron oscillators (gyromonotrons) are mainly used as high power millimeter wave sources for electron cyclotron resonance heating (ECRH), electron cyclotron current drive (ECCD), stability control and diagnostics of magnetically confined plasmas for generation of energy by controlled thermonuclear fusion. The maximum pulse length of commercially available 140 GHz, megawatt- class gyrotrons employing synthetic diamond output windows is 30 minutes (CPI and European KIT-CRPP-TED collaboration). The world record parameters of the European megawatt-class 140 GHz gyrotron are: 0.92 MW output power at 30 min. pulse duration, 97.5% Gaussian mode purity and 44% efficiency, employing a single-stage depressed collector (SDC) for energy recovery. A maximum output power of 1.5 MW in 4.0 s pulses at 45% efficiency was generated with the JAEA-TOSHIBA 110 GHz gyrotron. The Japan 170 GHz ITER gyrotron achieved 1 MW, 800 s at 55% efficiency and holds the energy world record of 2.88 GJ (0.8 MW, 60 min.) and the efficiency record of 57% for tubes with an output power of more than 0.5 MW. The Russian 170 GHz ITER gyrotron achieved 0.99 (1.2) MW with a pulse duration of 1000 (100) s and 53 (53) % efficiency. The prototype tube of the European 2 MW, 170 GHz coaxial-cavity gyrotron achieved in short pulses the record power of 2.1 MW at 46% efficiency and 96% Gaussian mode purity. Gyrotrons with pulsed magnet for various short-pulse applications deliver P{sub out}=210 kW with τ=20 μs at frequencies up to 670 GHz (η≅20%), P{sub out}=5.3 kW at 1 THz (η=6.1%), and P{sub out}=0.5 kW at 1.3 THz (η=0.6%). Gyrotron oscillators have also been successfully used in materials processing. Such technological applications require gyrotrons with the following parameters: f ≥ 24 GHz, P{sub out}=4-50 kW, CW, η≥30%. This paper gives an update of the experimental achievements related to the development of high power gyrotron oscillators for long-pulse or CW operation and pulsed gyrotrons for

State-of-the-art of high power gyro-devices and free electron masers 1994

International Nuclear Information System (INIS)

Thumm, M.

1995-04-01

At present, gyrotron oscillators are mainly used as high power millimeter wave sources for electron cyclotron resonance heating (ECRH) and diagnostics of magnetically confined plasmas for generation of energy by controlled thermonuclear fusion. 140 GHz gyrotrons with output power P out =0.54 MW, pulse length τ=3.0 s and efficiency η=42% are commercially available. Total efficiencies around 50% have been achieved using single-stage depressed collectors. Diagnostic gyrotrons deliver P out =40 kW with τ=40 μs at frequencies up to 650 GHz (η≥4%). Recently, gyrotron oscillators have also been successfully used in material processing and plasma chemistry. Such technological applications require gyrotrons with the following parameters: f≥24 GHz, P out =10-50 kW, CW, η≥30%. This paper reports on achievements and problems related to the development of very high power mm-wave gyrotrons for long pulse or CW operation and describes the microwave technological pecularities of the different development steps. In addition, this work gives a short overview of the present development of gyrotrons for technological applications, relativistic gyrotrons, quasi-optical gyrotrons, cyclotron autoresonance masers (CARMs), gyro klystrons, gyro-TWT amplifiers, gyrotwystron amplifiers, gyro-BWO's, peniotrons and free electron masers (FEMs). The most impressive FEM output parameters are: P out =2 GW, τ=20 ns, η=13% at 140 GHz (LLNL) and P out =15 kW, τ=20 μs, η=5% in the range from 120 to 900 GHz (UCSB). (orig.) [de

Dinitrosopiperazine-Mediated Phosphorylated-Proteins Are Involved in Nasopharyngeal Carcinoma Metastasis

Directory of Open Access Journals (Sweden)

Gongjun Tan

2014-11-01

Full Text Available N,N'-dinitrosopiperazine (DNP with organ specificity for nasopharyngeal epithelium, is involved in nasopharyngeal carcinoma (NPC metastasis, though its mechanism is unclear. To reveal the pathogenesis of DNP-induced metastasis, immunoprecipitation was used to identify DNP-mediated phosphoproteins. DNP-mediated NPC cell line (6-10B motility and invasion was confirmed. Twenty-six phosphoproteins were increased at least 1.5-fold following DNP exposure. Changes in the expression levels of selected phosphoproteins were verified by Western-blotting analysis. DNP treatment altered the phosphorylation of ezrin (threonine 567, vimentin (serine 55, stathmin (serine 25 and STAT3 (serine 727. Furthermore, it was shown that DNP-dependent metastasis is mediated in part through ezrin at threonine 567, as DNP-mediated metastasis was decreased when threonine 567 of ezrin was mutated. Strikingly, NPC metastatic tumors exhibited a higher expression of phosphorylated-ezrin at threonine 567 than the primary tumors. These findings provide novel insight into DNP-induced NPC metastasis and may contribute to a better understanding of the metastatic mechanisms of NPC tumors.

Influence of PUVA and UVB radiation on delayed hypersensitivity in the guinea pig

International Nuclear Information System (INIS)

Morison, W.L.; Parrish, J.A.; Woehler, M.E.; Krugler, J.I.; Bloch, K.J.

1981-01-01

Exposure of guinea pigs to UVA (320--400 nm) radiation following administration of 8-methoxypsoralen by gavage (referred to by the acronym, PUVA) or exposure to UVB (290--320 nm) radiation, produced suppression of the cutaneous delayed hypersensitivity reaction at the site of exposure to radiation and at distant nonexposed sites. In these experiments, the animals were immunized by injection of dinitrophenyl-bovine gamma-globulin (DNP-BGG) in complete Freund's adjuvant and delayed hypersensitivity responses were provoked by intradermal injections of DNP-BGG, DNP and BGG on the flanks. Exposure to erythemogenic doses of either PUVA or UVB radiation for 7 days prior to immunization and for the 7 days between immunization and challenge (total period of radiation: 14 days) produced inhibiton of responses to each of the test substances. In addition, treatment with erythemogenic doses of PUVA either for 7 days prior to immunization or during the interval between immunization and challenge with DNP-BGG, inhibited the delayed hypersensitivity responses at the site of irradiation and at a nonexposed site. These findings suggest that in vivo exposure to nonionizing radiation leads to both local and systemic alteration of certain immune responses

Intestinal absorption of dinitrophenyl-lysine and effect of immunization with dinitrophenylated bovine serum albumin

International Nuclear Information System (INIS)

Shimura, Fumio; Shimura, Junko; Shimazaki, Shigeki; Hosoya, Norimasa

1983-01-01

The intestinal absorption of dinitrophenyl-lysine (DNP-lys) was studied with a special interest on the role of the immune system in the absorption of small molecules which are recognized as nonself. [ 3 H]-DNP- lys was rapidly absorbed by ligated intestinal loops in situ via a saturable and unique route. When [ 3 H]-DNP-lys was preincubated with the immume serum obtained from rats immunized with dinitrophenylated bovine serum albumin (DNP-BSA), the [ 3 H]-DNP-lys absorption was depressed. The absorption of [ 3 H]-DNP-lys in DNP-BSA-immunized rats was depressed compared to the control. The results obtained suggest that the immune system play a role in avoiding the absorption of small molecules with antigenicity. (author)

Dynamic Nuclear Polarization enhanced NMR at 187 GHz/284 MHz using an Extended Interaction Klystron amplifier.

Science.gov (United States)

Kemp, Thomas F; Dannatt, Hugh R W; Barrow, Nathan S; Watts, Anthony; Brown, Steven P; Newton, Mark E; Dupree, Ray

2016-04-01

A Dynamic Nuclear Polarisation (DNP) enhanced solid-state Magic Angle Spinning (MAS) NMR spectrometer which uses a 187 GHz (corresponding to (1)H NMR frequency of 284 MHz) Extended Interaction Klystron (EIK) amplifier as the microwave source is briefly described. Its performance is demonstrated for a biomolecule (bacteriorhodopsin), a pharmaceutical, and surface functionalised silica. The EIK is very compact and easily incorporated into an existing spectrometer. The bandwidth of the amplifier is sufficient that it obviates the need for a sweepable magnetic field, once set, for all commonly used radicals. The variable power (CW or pulsed) output from the EIK is transmitted to the DNP-NMR probe using a quasi-optic system with a high power isolator and a corrugated waveguide which feeds the microwaves into the DNP-NMR probe. Curved mirrors inside the probe project the microwaves down the axis of the MAS rotor, giving a very efficient system such that maximum DNP enhancement is achieved with less than 3 W output from the microwave source. The DNP-NMR probe operates with a sample temperature down to 90K whilst spinning at 8 kHz. Significant enhancements, in excess of 100 for bacteriorhodopsin in purple membrane (bR in PM), are shown along with spectra which are enhanced by ≈25 with respect to room temperature, for both the pharmaceutical furosemide and surface functionalised silica. These enhancements allow hitherto prohibitively time consuming experiments to be undertaken. The power at which the DNP enhancement in bR in PM saturates does not change significantly between 90K and 170 K even though the enhancement drops by a factor of ≈11. As the DNP build up time decreases by a factor 3 over this temperature range, the reduction in T1n is presumably a significant contribution to the drop in enhancement. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

State-of-the-art of high power gyro-devices and free electron masers

International Nuclear Information System (INIS)

Thumm, M.

1993-10-01

At present, gyrotron oscillators are mainly used as high power millimeter wave sources for electron cyclotron resonance heating (ECRH) and diagnostics of magnetically confined plasmas for generation of energy by controlled thermonuclear fusion. 140 GHz gyrotrons with output power P out = 0.58 MW, pulse length τ = 2.0 s and efficiency η = 34% are commercially available. Diagnostic gyrotrons deliver P out = 40 kW with τ = 40 μs at frequencies up to 650 GHz (η ≥ 4%). Recently, gyrotron oscillators have also been successfully used in material processing and plasma chemistry. Such technological applications require gyrotrons with the following parameters: f ≥ 28 GHz, P out = 10-30 kW, CW, η ≥ 30%. This paper reports on achievements and problems related to the development of very high power mm-wave gyrotrons for long pulse or CW operation and describes the microwave technological pecularities of the different development steps. In addition, this work gives a short overview of the present development of gyrotrons for technological applications, quasi-optical gyrotrons, cyclotron autoresonance masers (CARMs), gyro-klystrons, gyro-TWT amplifiers, gyro-BWO's and free electron masers (FEMs). The most impressive FEM output parameters are: P out = 2 GW, τ = 20 ns, η = 13% at 140 GHz (LLNL) and P out = 15 kW, τ = 20 μs, η = 5% in the range from 120 to 900 GHz (UCSB). (orig.) [de

N,N'-dinitrosopiperazine--mediated heat-shock protein 70-2 expression is involved in metastasis of nasopharyngeal carcinoma.

Directory of Open Access Journals (Sweden)

Zhengke Peng

Full Text Available N,N'-Dinitrosopiperazine (DNP is invovled in nasopharyngeal carcinoma (NPC development and metastasis, and it shows organ specificity to the nasopharyngeal epithelium. Herein, we demonstrate that DNP induces heat-shock protein (HSP 70-2 expression in NPC cells (6-10B at a non-cytotoxic concentration. DNP induced HSP70-2 expression in a dose- and time- dependent manner, but showed no effect on other HSP70 family members. Furthermore, DNP also increased HSP70-2 RNA transcription through directly binding to the hypoxia-responsive elements (HRE and heat shock elements (HSE located in the HSP70-2 promoter. DNP-mediated HSP70-2 expression might act through enhancing the transcription of HSP70-2 RNA. Importantly, DNP induced motility and invasion of 6-10B cells dose- and time-dependently, and DNP-mediated NPC metastasis was confirmed in nude mice, which showed high HSP70-2 expression in the metastatic tumor tissue. However, the motility and invasion of NPC cells that were stably transfected using short interfering RNA against HSP70-2 could not effectively induce DNP. These results indicate that DNP induces HSP70-2 expression through increasing HSP70-2 transcription, increases the motility and invasion of cells, and promotes NPC tumor metastasis. Therefore, DNP mediated HSP70-2 expression may be an important factor of NPC-high metastasis.

Instrumentation for cryogenic magic angle spinning dynamic nuclear polarization using 90L of liquid nitrogen per day.

Science.gov (United States)

Albert, Brice J; Pahng, Seong Ho; Alaniva, Nicholas; Sesti, Erika L; Rand, Peter W; Saliba, Edward P; Scott, Faith J; Choi, Eric J; Barnes, Alexander B

2017-10-01

Cryogenic sample temperatures can enhance NMR sensitivity by extending spin relaxation times to improve dynamic nuclear polarization (DNP) and by increasing Boltzmann spin polarization. We have developed an efficient heat exchanger with a liquid nitrogen consumption rate of only 90L per day to perform magic-angle spinning (MAS) DNP experiments below 85K. In this heat exchanger implementation, cold exhaust gas from the NMR probe is returned to the outer portion of a counterflow coil within an intermediate cooling stage to improve cooling efficiency of the spinning and variable temperature gases. The heat exchange within the counterflow coil is calculated with computational fluid dynamics to optimize the heat transfer. Experimental results using the novel counterflow heat exchanger demonstrate MAS DNP signal enhancements of 328±3 at 81±2K, and 276±4 at 105±2K. Copyright © 2017 Elsevier Inc. All rights reserved.

Design and measurement of a TE{sub 13} input converter for high order mode gyrotron travelling wave amplifiers

Energy Technology Data Exchange (ETDEWEB)

Wang, Yan; Liu, Guo, E-mail: liuguo@uestc.edu.cn; Shu, Guoxiang; Yan, Ran; Wang, Li; Agurgo Balfour, E.; Fu, Hao; Luo, Yong [School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu 610054 (China); Wang, Shafei, E-mail: rockingsandstorm@163.com [North Electronic Device Research Institution, Box 947, Beijing 100141 (China)

2016-03-15

A technique to launch a circular TE{sub 13} mode to interact with the helical electron beam of a gyrotron travelling wave amplifier is proposed and verified by simulation and cold test in this paper. The high order (HOM) TE{sub 13} mode is excited by a broadband Y-type power divider with the aid of a cylindrical waveguide system. Using grooves and convex strips loaded at the lateral planes of the output cylindrical waveguide, the electric fields of the potential competing TE{sub 32} and TE{sub 71} modes are suppressed to allow the transmission of the dominant TE{sub 13} mode. The converter performance for different structural dimensions of grooves and convex strips is studied in detail and excellent results have been achieved. Simulation predicts that the average transmission is ∼−1.8 dB with a 3 dB bandwidth of 7.2 GHz (91.5–98.7 GHz) and port reflection is less than −15 dB. The conversion efficiency to the TE{sub 32} and TE{sub 71} modes are, respectively, under −15 dB and −24 dB in the operating frequency band. Such an HOM converter operating at W-band has been fabricated and cold tested with the radiation boundary. Measurement from the vector network analyzer cold test and microwave simulations show a good reflection performance for the converter.

NTM stabilization by alternating O-point EC current drive using a high-power diplexer

Science.gov (United States)

Kasparek, W.; Doelman, N.; Stober, J.; Maraschek, M.; Zohm, H.; Monaco, F.; Eixenberger, H.; Klop, W.; Wagner, D.; Schubert, M.; Schütz, H.; Grünwald, G.; Plaum, B.; Munk, R.; Schlüter, K. H.; ASDEX Upgrade Team

2016-12-01

At the tokamak ASDEX Upgrade, experiments to stabilize neoclassical tearing modes (NTMs) by electron cyclotron (EC) heating and current drive in the O-points of the magnetic islands were performed. For the first time, injection into the O-points of the revolving islands was performed via a fast directional switch, which toggled the EC power between two launchers synchronously to the island rotation. The switching was performed by a resonant diplexer employing a sharp resonance in the transfer function, and a small frequency modulation of the feeding gyrotron around the slope of the resonance. Thus, toggling of the power between the two outputs of the diplexer connected to two articulating launchers was possible. Phasing and control of the modulation were performed via a set of Mirnov coils and appropriate signal processing. In the paper, technological issues, the design of the diplexer, the tracking of the diplexer resonance to the gyrotron frequency, the generation and processing of control signals for the gyrotron, and the typical performance concerning switching contrast and efficiency are discussed. The plasma scenario is described, and plasma experiments are presented, where the launchers scanned the region of the resonant surface continuously and also where the launchers were at a fixed position near to the q  =  1.5-surface. In the second case, complete stabilization of a 3/2 NTM could be reached. These experiments are also seen as a technical demonstration for the applicability of diplexers in large-scale ECRH systems.

Dendroaspis natriuretic peptide binds to the natriuretic peptide clearance receptor

International Nuclear Information System (INIS)

Johns, Douglas G.; Ao, Zhaohui; Heidrich, Bradley J.; Hunsberger, Gerald E.; Graham, Taylor; Payne, Lisa; Elshourbagy, Nabil; Lu, Quinn; Aiyar, Nambi; Douglas, Stephen A.

2007-01-01

Dendroaspis natriuretic peptide (DNP) is a newly-described natriuretic peptide which lowers blood pressure via vasodilation. The natriuretic peptide clearance receptor (NPR-C) removes natriuretic peptides from the circulation, but whether DNP interacts with human NPR-C directly is unknown. The purpose of this study was to test the hypothesis that DNP binds to NPR-C. ANP, BNP, CNP, and the NPR-C ligands AP-811 and cANP(4-23) displaced [ 125 I]-ANP from NPR-C with pM-to-nM K i values. DNP displaced [ 125 I]-ANP from NPR-C with nM potency, which represents the first direct demonstration of binding of DNP to human NPR-C. DNP showed high pM affinity for the GC-A receptor and no affinity for GC-B (K i > 1000 nM). DNP was nearly 10-fold more potent than ANP at stimulating cGMP production in GC-A expressing cells. Blockade of NPR-C might represent a novel therapeutic approach in augmenting the known beneficial actions of DNP in cardiovascular diseases such as hypertension and heart failure

Massachusetts Institute of Technology Plasma Fusion Center 1992--1993 report to the President

International Nuclear Information System (INIS)

1993-07-01

This report discusses research being conducted at MIT's plasma fusion center. Some of the areas covered are: plasma diagnostics; rf plasma heating; gyrotron research; treatment of solid waste by arc plasma; divertor experiments; tokamak studies; and plasma and fusion theory

A peripheral component interconnect express-based scalable and highly integrated pulsed spectrometer for solution state dynamic nuclear polarization

Energy Technology Data Exchange (ETDEWEB)

He, Yugui; Liu, Chaoyang, E-mail: chyliu@wipm.ac.cn [Wuhan National Laboratory for Optoelectronics, School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074 (China); State Key Laboratory of Magnet Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071 (China); Feng, Jiwen; Wang, Dong; Chen, Fang; Liu, Maili [State Key Laboratory of Magnet Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071 (China); Zhang, Zhi; Wang, Chao [State Key Laboratory of Magnet Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071 (China); University of Chinese Academy of Sciences, Beijing 100048 (China)

2015-08-15

High sensitivity, high data rates, fast pulses, and accurate synchronization all represent challenges for modern nuclear magnetic resonance spectrometers, which make any expansion or adaptation of these devices to new techniques and experiments difficult. Here, we present a Peripheral Component Interconnect Express (PCIe)-based highly integrated distributed digital architecture pulsed spectrometer that is implemented with electron and nucleus double resonances and is scalable specifically for broad dynamic nuclear polarization (DNP) enhancement applications, including DNP-magnetic resonance spectroscopy/imaging (DNP-MRS/MRI). The distributed modularized architecture can implement more transceiver channels flexibly to meet a variety of MRS/MRI instrumentation needs. The proposed PCIe bus with high data rates can significantly improve data transmission efficiency and communication reliability and allow precise control of pulse sequences. An external high speed double data rate memory chip is used to store acquired data and pulse sequence elements, which greatly accelerates the execution of the pulse sequence, reduces the TR (time of repetition) interval, and improves the accuracy of TR in imaging sequences. Using clock phase-shift technology, we can produce digital pulses accurately with high timing resolution of 1 ns and narrow widths of 4 ns to control the microwave pulses required by pulsed DNP and ensure overall system synchronization. The proposed spectrometer is proved to be both feasible and reliable by observation of a maximum signal enhancement factor of approximately −170 for {sup 1}H, and a high quality water image was successfully obtained by DNP-enhanced spin-echo {sup 1}H MRI at 0.35 T.

Thermosetting polymer for dynamic nuclear polarization: Solidification of an epoxy resin mixture including TEMPO

Energy Technology Data Exchange (ETDEWEB)

Noda, Yohei, E-mail: noda.yohei@jaea.go.jp [Quantum Beam Science Centre, Sector of Nuclear Science Research, Japan Atomic Energy Agency, Shirakata-Shirane, Tokai, Ibaraki 319-1195 (Japan); Kumada, Takayuki [Quantum Beam Science Centre, Sector of Nuclear Science Research, Kansai Photon Science Institute, Japan Atomic Energy Agency, Kizugawa, Kyoto 619-0215 (Japan); Yamaguchi, Daisuke; Shamoto, Shin-ichi [Quantum Beam Science Centre, Sector of Nuclear Science Research, Japan Atomic Energy Agency, Shirakata-Shirane, Tokai, Ibaraki 319-1195 (Japan)

2015-03-11

We investigated the dynamic nuclear polarization (DNP) of typical thermosetting polymers (two-component type epoxy resins; Araldite{sup ®} Standard or Araldite{sup ®} Rapid) doped with a (2,2,6,6-tetramethylpiperidine-1-yl)oxy (TEMPO) radical. The doping process was developed by carefully considering the decomposition of TEMPO during the solidification of the epoxy resin. The TEMPO electron spin in each two-component paste decayed slowly, which was favorable for our study. Furthermore, despite the dissolved TEMPO, the mixture of the two-component paste successfully solidified. With the resulting TEMPO-doped epoxy-resin samples, DNP experiments at 1.2 K and 3.35 T indicated a magnitude of a proton-spin polarization up to 39%. This polarization is similar to that (35%) obtained for TEMPO-doped polystyrene (PS), which is often used as a standard sample for DNP. To combine this solidification of TEMPO-including mixture with a resin-casting technique enables a creation of polymeric target materials with a precise and complex structure.

Recent results of plasma research activities at the Instituto de Pesquisas Espaciais

International Nuclear Information System (INIS)

Barroso, J.J.; Bittencourt, J.A.; Dallaqua, R.S.; Del Bosco, E.; Ferreira, A.; Ferreira, J.L.; Galvao, G.P.; Galvao, R.M.O.; Ludwig, G.O.; Montes, A.

1987-09-01

Recent results obtained in different experiments at the Institute for Space Research (INPE) are reported. An enrichment of 390% of carbon isotopes has been achieved in the plasma centrifege. The role of ion-acoustic turbulence in the formation of double layers has been experimentaly investigated. The turbulent spectrum has been measured and agrees quite well with the prediction of the modified Kadomtsev's renormalized theory. The characteristics of the gyrotron that is presently being built at INPE and new techniques for gyrotron design are discussed. Thecretical results on the generalized Spitzer-Harm problem, current drive in the start-up phase of Tokamaks, and quasilinear theory of beat-wave current drive are also presented. (author) [pt

Analysis and design of double-anode magnetron injection gun

International Nuclear Information System (INIS)

Yang Tie; Niu Xinjian; Liu Yinghui

2013-01-01

Based on electro-optical theory and adiabatic compression theory, a double-anode magnetic injection gun for TE 34,19 , 170 GHz gyrotron was analyzed and designed with EGUN software. Concerning with the factors such as positions of anode and magnetic field distance between anodes, we obtained the result that the velocity ratio of electron beam approximated 1.3, and the velocity spread was under 3%. Furthermore, we found that electron beam was sensitive with these factors, such as that the velocity ratio decreased when the distance between anodes increased, while the velocity spread decreased first and then increased. The double-anode magnetic injection gun is employed in the experiments of gyrotron. (authors)

Measurements Techniques for Gyrotron characterization

International Nuclear Information System (INIS)

Castro, P.J. de.

1987-08-01

Experiments planned for the characterization of the 35GHz girotron, which is being built at the Plasma Laboratory of INPE, are described. The methods of the measurements are presented and the required instrumentation and devices are specified. Special attention is given to the measurement techniques of the resonator electric field profile. (author) [pt

Efficiencies of Low-Level Laser Therapy (LLLT) and Gabapentin in the Management of Peripheral Neuropathy: Diabetic Neuropathy.

Science.gov (United States)

Abdel-Wahhab, Khaled G; Daoud, Eitedal M; El Gendy, Aliaa; Mourad, Hagar H; Mannaa, Fathia A; Saber, Maha M

2018-03-12

Diabetic neuropathy (DN) is the highly occurred complication of diabetes mellitus; it has been defined as an event of peripheral nerve dysfunction characterized by pain, allodynia, hyperalgesia, and paraesthesia. The current study was conducted to evaluate the efficacy of low-level laser therapy (LLLT) in the management of neuropathy in diabetic rats. The used animals were divided into the following groups: negative control, streptozotocin-induced diabetic rats, and diabetic rats with peripheral neuropathy (DNP) and DNP treated with gabapentin or with LLLT. Behavioral tests were carried out through hotplate test for the determination of pain sensations and the Morris water maze test for spatial reference memory evaluation. Blood samples were collected at the end of treatment for biochemical determinations. In the current study, the latency of hind-paw lick decreased significantly when DNP are treated with gabapentin or LLLT. The Morris water maze test showed that LLLT treatment improved memory that deteriorated in DNP more than gabapentin do. The results of the biochemical study revealed that LLLT could not affect the level of beta-endorphin that decreased in DNP but significantly decreased S100B that rose in DNP. PGE2 and cytokines IL-1β, IL-10, and TNF-α showed significant increase in DNP compared with control group. The gabapentin administration or LLLT application significantly reversed the levels of the mentioned markers towards the normal values of the controls. Levels of serum MDA and nitric oxide increased significantly in the DNP but rGSH showed significant decrease. These markers were improved significantly when the DNP were treated with gabapentin or LLLT. The treatment with gabapentin or LLLT significantly decreased the raised level in total cholesterol in DNP but could not decrease the elevated level of triglycerides, while LDL cholesterol decreased significantly in DNP treated with gabapentin but not affected by LLLT. Values of serum alanine

Dynamic Nuclear Polarization and other magnetic ideas at EPFL.

Science.gov (United States)

Bornet, Aurélien; Milani, Jonas; Wang, Shutao; Mammoli, Daniele; Buratto, Roberto; Salvi, Nicola; Segaw, Takuya F; Vitzthum, Veronika; Miéville, Pascal; Chinthalapalli, Srinivas; Perez-Linde, Angel J; Carnevale, Diego; Jannin, Sami; Caporinia, Marc; Ulzega, Simone; Rey, Martial; Bodenhausen, Geoffrey

2012-01-01

Although nuclear magnetic resonance (NMR) can provide a wealth of information, it often suffers from a lack of sensitivity. Dynamic Nuclear Polarization (DNP) provides a way to increase the polarization and hence the signal intensities in NMR spectra by transferring the favourable electron spin polarization of paramagnetic centres to the surrounding nuclear spins through appropriate microwave irradiation. In our group at EPFL, two complementary DNP techniques are under investigation: the combination of DNP with magic angle spinning at temperatures near 100 K ('MAS-DNP'), and the combination of DNP at 1.2 K with rapid heating followed by the transfer of the sample to a high-resolution magnet ('dissolution DNP'). Recent applications of MAS-DNP to surfaces, as well as new developments of magnetization transfer of (1)H to (13)C at 1.2 K prior to dissolution will illustrate the work performed in our group. A second part of the paper will give an overview of some 'non-enhanced' activities of our laboratory in liquid- and solid-state NMR.

Large power electron tubes for high frequency heating

International Nuclear Information System (INIS)

Okamoto, Tadashi; Sato, Hisaaki.

1988-01-01

On the large power electron tubes used for electron cyclotron heating, lower hybrid resonance frequency heating, and ion cyclotron range of frequency heating, namely gyrotron, klystron and quadrupole tube, the features, the present status of development, the construction, the principle and so on are explained. The research and development of gyrotrons are most advanced in USSR, the inventor. The course of the development of gyrotrons in foreign countries and in Japan is described. There are many variants of gyrotrons, for example whispering gallery mode, klystron type, backward wave oscillator type, gyro-peniotron and others. The principle of gyrotrons is explained, and about the examples of the developed gyrotrons, the design parameters are shown. For the purpose of using for the LHRF heating in JT-60, a superlarge power klystron of 1 MW output at 2 GHz frequency, which is the largest class in the world, has been developed. Its total length is 2.7 m, and weight is 1.5 t. It features, construction, function and performance are reported. The trend of large power quadrupole tubes is toward stable action with large power in VHF zone, and the typical products in USA and Europe are shown. (Kako, I.)

TFTR 60 GHz alpha particle collective Thomson Scattering diagnostic

International Nuclear Information System (INIS)

Machuzak, J.S.; Woskov, P.P.; Gilmore, J.; Bretz, N.L.; Park, H.K.; Bindslev, H.

1995-03-01

A 60 GHz gyrotron collective Thomson Scattering alpha particle diagnostic has been implemented for the D-T period on TFM. Gyrotron power of 0.1-1 kW in pulses of up to 1 second can be launched in X-mode. Efficient corrugated waveguides are used with antennaes and vacuum windows of the TFTR Microwave Scattering system. A multichannel synchronous detector receiver system and spectrum analyzer acquire the scattered signals. A 200 Megasample/sec digitizer is used to resolve fine structure in the frequency spectrum. By scattering nearly perpendicular to the magnetic field, this experiment will take advantage of an enhancement of the scattered signal which results from the interaction of the alpha particles with plasma resonances in the lower hybrid frequency range. Significant enhancements are expected, which will make these measurements possible with gyrotron power less than 1 kW, while maintaining an acceptable signal to noise ratio. We hope to extract alpha particle density and velocity distribution functions from the data. The D and T fuel densities and temperatures may also be obtainable by measurement of the respective ion cyclotron harmonic frequencies

Chief nursing officers' perceptions of the Doctorate of Nursing Practice degree.

Science.gov (United States)

Swanson, Michelle L; Stanton, Marietta P

2013-01-01

Nurse executives practice in a business environment, which requires a skill set that has traditionally not been included in advanced nursing curriculum. The Doctorate of Nursing Practice (DNP) essentials are designed to address this gap in education while maintaining the focus on advanced nursing practice and executive management competency. Current literature supports the appropriateness of the DNP with practice focus areas of advanced practice specialties and nursing leadership. Although certification and educational bodies, and some professional nursing organizations, have embraced the DNP as the terminal degree for non-research-focused nurses, there remains a gap in the literature in regards to the perceptions of validity of the DNP for nurse executives. The purpose of this capstone project was to investigate the perceptions of practicing chief nursing officers (CNOs) in the acute care setting regarding the application of the DNP degree for nurse leaders. Utilizing an online survey, specific perceptions investigated included application and appropriateness of the DNP in a business-based practice model and managing daily nursing operations. CNOs practicing in the acute care setting differed on their responses regarding whether the DNP should be the recommended or the required degree in CNO development programs. CNOs with tenure responded more positively to the perception that the DNP curricula contains advanced nursing knowledge content appropriate to nurse executive practice. Practicing CNOs in the acute care setting do perceive the DNP as an appropriate degree option for nurse executive roles at aggregate, system, and organizational levels. © 2013 Wiley Periodicals, Inc.

2 MW 110 GHz ECH heating system for DIII-D

International Nuclear Information System (INIS)

Moeller, C.; Prater, R.; Callis, R.; Remsen, D.; Doane, J.; Cary, W.; Phelps, R.; Tupper, M.

1990-09-01

A 2 MW 110 GHz ECH system using Varian 0.5 MW gyrotrons is under construction for use on the DIII-D tokamak by late 1991. Most of the components are being design and fabricated at General Atomics, including the gyrotron tanks, superconducting magnets, and transmission line. These components are intended for operation with 10 second pulses and, in the future, with 1 MW gyrotrons. 6 refs., 5 figs

The ECRH system for dite and compass experiments

International Nuclear Information System (INIS)

Riviere, A.C.; Alcock, M.W.; Collins, P.R.; Ainsworth, N.R.; Dellis, A.N.; Moody, D.; Goodenough, S.; Green, S.R.

1987-01-01

Electron Cyclotron Resonance Heating is one of the main auxiliary heating mechanisms in the Culham Laboratory Fusion programme. The system described here is aimed initially at injecting 0.6MW of 60 GHz power into the existing DITE tokamak. A planned increase in power by the addition of further stages will result in a system capable of delivering up to 2MW of power at 60 GHz into the new COMPASS tokamak currently under construction. The scientific aims and the general technical structure of the system are described. The description will cover layout, power supplies, cooling systems, safety and the microwave transmission system necessary to convey the power from the gyrotron sources to the plasmas which can be situated up to 50 metres distant. A highly specialized transmission line consisting of circular overmoded waveguide with filters, bends and mode converters is necessary and data are presented showing the performance of these items and their method of manufacture. Most of these units have been previously tested on the CLEO experiment. In addition to the 2 MW 60 GHz system a single 200 KW source at 28 GHz will be used for preionisation

Thrust generation experiments on microwave rocket with a beam concentrator for long distance wireless power feeding

Science.gov (United States)

Fukunari, Masafumi; Yamaguchi, Toshikazu; Nakamura, Yusuke; Komurasaki, Kimiya; Oda, Yasuhisa; Kajiwara, Ken; Takahashi, Koji; Sakamoto, Keishi

2018-04-01

Experiments using a 1 MW-class gyrotron were conducted to examine a beamed energy propulsion rocket, a microwave rocket with a beam concentrator for long-distance wireless power feeding. The incident beam is transmitted from a beam transmission mirror system. The beam transmission mirror system expands the incident beam diameter to 240 mm to extend the Rayleigh length. The beam concentrator receives the beam and guides it into a 56-mm-diameter cylindrical thruster tube. Plasma ignition and ionization front propagation in the thruster were observed through an acrylic window using a fast-framing camera. Atmospheric air was used as a propellant. Thrust generation was achieved with the beam concentrator. The maximum thrust impulse was estimated as 71 mN s/pulse from a pressure history at the thrust wall at the input energy of 638 J/pulse. The corresponding momentum coupling coefficient, Cm was inferred as 204 N/MW.

The evolution of a doctor of nursing practice capstone process: programmatic revisions to improve the quality of student projects.

Science.gov (United States)

Nelson, Joan M; Cook, Paul F; Raterink, Ginger

2013-01-01

The past several years have seen explosive growth in the number of doctor of nursing practice (DNP) degree programs offered by colleges of nursing in the United States. Through a process of trial and error since 2005, the faculty at the University of Colorado, College of Nursing, have revised the course structure and procedures related to the DNP capstone project to improve the quality and usefulness of these student projects. Efforts have focused on educating and involving all nursing faculty in the DNP capstone process, distinguishing between competencies for our PhD and DNP projects, clearly aligning the DNP capstone project with quality improvement methods rather than with research, working with our campus institutional review board to clarify regulatory review requirements for quality improvement studies, developing a review committee to oversee DNP students' projects, and structuring our sequential course requirements to encourage students' professional presentations and publications. Our current capstone process reflects 7 years of iterative work, which we summarize in this article in hopes that it will help institutions currently in the process of developing a DNP program. Copyright © 2013 Elsevier Inc. All rights reserved.

Bis-gadolinium complexes for solid effect and cross effect dynamic nuclear polarization

Energy Technology Data Exchange (ETDEWEB)

Kaushik, Monu; Corzilius, Bjoern [Goethe-Universitaet Frankfurt am Main, Institut fuer Physikalische und Theoretische Chemie, Institut fuer Biophysikalische Chemie und Biomolekulares Magnetresonanzzentrum (BMRZ) (Germany); Qi, Mian; Godt, Adelheid [Fakultaet fuer Chemie und Centrum fuer Molekulare Materialien (CM2), Universitaet Bielefeld (Germany)

2017-04-03

High-spin complexes act as polarizing agents (PAs) for dynamic nuclear polarization (DNP) in solid-state NMR spectroscopy and feature promising aspects towards biomolecular DNP. We present a study on bis(Gd-chelate)s which enable cross effect (CE) DNP owing to spatial confinement of two dipolar-coupled electron spins. Their well-defined Gd..Gd distances in the range of 1.2-3.4 nm allowed us to elucidate the Gd..Gd distance dependence of the DNP mechanism and NMR signal enhancement. We found that Gd..Gd distances above 2.1 nm result in solid effect DNP while distances between 1.2 and 2.1 nm enable CE for {sup 1}H, {sup 13}C, and {sup 15}N nuclear spins. We compare 263 GHz electron paramagnetic resonance (EPR) spectra with the obtained DNP field profiles and discuss possible CE matching conditions within the high-spin system and the influence of dipolar broadening of the EPR signal. Our findings foster the understanding of the CE mechanism and the design of high-spin PAs for specific applications of DNP. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

EBT-S 28-GHz, 200-kW, CW, mixed-mode, quasi-optical plasma heating system

International Nuclear Information System (INIS)

White, T.L.; Kimrey, H.D.; Bigelow, T.S.; Bates, D.D.; Eason, H.O.

1984-07-01

The ELMO Bumpy Torus-Scale (EBT-S) 28-GHz, 200-kW, cw, plasma heating system consists of a gyrotron oscillator, an oversized waveguide two-bend transmission system, and a quasi-optical mixed-mode microwave distribution manifold that feeds microwave power to the 24 plasma loads of the EBT-S fusion experiment. Balancing power to the 24 loads of the EBT-S fusion experiment. Balancing power to the 24 loads was achieved by adjusting the areas at 24 coupling irises. System performance is easily measured using system calorimetry. The distribution manifold mixed-mode power transmission, reflection, and loss coefficients are 89%, 6%, and 5%, respectively. The overall system efficiency (plasma power/gyrotron power) is 80%, but with some modifications to the distribution manifold we believe the ultimate efficiency can approach 90%. The system reliability is outstanding with a world's record 1 x 10 5 kW h of 28-GHz energy delivered to the EBT-S device with well over 1 x 10 3 operating hours

Goethite promoted biodegradation of 2,4-dinitrophenol under nitrate reduction condition.

Science.gov (United States)

Tang, Ting; Yue, Zhengbo; Wang, Jin; Chen, Tianhu; Qing, Chengsong

2018-02-05

Iron oxide may interact with other pollutants in the aquatic environments and further influence their toxicity, transport and fate. The current study was conducted to investigate the biodegradation of 2,4-dinitrophenol (2,4-DNP) in the presence of iron oxide of goethite under anoxic condition using nitrate as the electron acceptor. Experiment results showed that the degradation rate of 2,4-DNP was improved by goethite. High performance liquid chromatography-mass spectra analysis results showed that goethite promoted degradation and transformation of 2,4-diaminophenol and 2-amino-4-nitrophenol (2-nitro-4-aminophenol). Microbial community analysis results showed that the abundance of Actinobacteria, which have the potential ability to degrade PAHs, was increased when goethite was available. This might partially explain the higher degradation of 2,4-DNP. Furthermore, another bacterium of Desulfotomaculum reducens which could reduce soluble Fe(III) and nitrate was also increased. Results further confirmed that nanomaterials in the aquatic environment will influence the microbial community and further change the transformation process of toxic pollutants. Copyright © 2017 Elsevier B.V. All rights reserved.

Prospects for sub-micron solid state nuclear magnetic resonance imaging with low-temperature dynamic nuclear polarization.

Science.gov (United States)

Thurber, Kent R; Tycko, Robert

2010-06-14

We evaluate the feasibility of (1)H nuclear magnetic resonance (NMR) imaging with sub-micron voxel dimensions using a combination of low temperatures and dynamic nuclear polarization (DNP). Experiments are performed on nitroxide-doped glycerol-water at 9.4 T and temperatures below 40 K, using a 30 mW tunable microwave source for DNP. With DNP at 7 K, a 0.5 microL sample yields a (1)H NMR signal-to-noise ratio of 770 in two scans with pulsed spin-lock detection and after 80 db signal attenuation. With reasonable extrapolations, we infer that (1)H NMR signals from 1 microm(3) voxel volumes should be readily detectable, and voxels as small as 0.03 microm(3) may eventually be detectable. Through homonuclear decoupling with a frequency-switched Lee-Goldburg spin echo technique, we obtain 830 Hz (1)H NMR linewidths at low temperatures, implying that pulsed field gradients equal to 0.4 G/d or less would be required during spatial encoding dimensions of an imaging sequence, where d is the resolution in each dimension.

Dynamic nuclear polarization of irradiated target materials

International Nuclear Information System (INIS)

Seely, M.L.

1982-01-01

Polarized nucleon targets used in high energy physics experiments usually employ the method of dynamic nuclear polarization (DNP) to polarize the protons or deuterons in an alcohol. DNP requires the presence of paramagnetic centers, which are customarily provided by a chemical dopant. These chemically doped targets have a relatively low polarizable nucleon content and suffer from loss of polarization when subjected to high doses of ionizing radiation. If the paramagnetic centers formed when the target is irradiated can be used in the DNP process, it becomes possible to produce targets using materials which have a relatively high polarizable nucleon content, but which are not easily doped by chemical means. Furthermore, the polarization of such targets may be much more radiation resistant. Dynamic nuclear polarization in ammonia, deuterated ammonia, ammonium hydroxide, methylamine, borane ammonia, butonal, ethane and lithium borohydride has been studied. These studies were conducted at the Stanford Linear Accelerator Center using the Yale-SLAC polarized target system. Results indicate that the use of ammonia and deuterated ammonia as polarized target materials would make significant increases in polarized target performance possible

Carprofen-induced oxidative stress in mitochondria of the colonic mucosa of the dog.

Science.gov (United States)

Snow, Lynne A; McConnico, Rebecca S; Morgan, Timothy W; Hartmann, Erica; Davidson, Jacqueline R; Hosgood, Giselle

2014-07-01

The purpose of the study was to compare the conductance and mannitol permeability of canine colonic mucosa in response to carprofen or 2,4-dinitrophenol (DNP) with or without tempol pretreatment. Ten colonic mucosa sections per dog were mounted in Ussing chambers. Treatments were done in duplicate. Mucosa was exposed to carprofen (200 μg/mL) or DNP (0.25 mM), both with and without tempol (1 mM) pretreatment. Conductance was calculated every 15 min for 240 min. Mannitol flux was calculated over 3 consecutive 60-minute periods. Histology or electron microscopy was done after exposure. Conductance over time, mannitol flux, frequency of histologic categories, and electron microscopic changes were analyzed for treatment effects. The mean ± standard deviation (SD) conductance over time for carprofen or DNP-treated colons was not significantly different from control regardless of tempol pretreatment. Period 3 mannitol fluxes for carprofen and DNP-treated colon were not significantly different, but were greater than control. Period 3 mannitol flux for tempol + carprofen was significantly less than tempol + DNP-treated colon. Sloughing of cells and erosions were seen in the mucosa of carprofen-treated colon. Mitochondrial damage was seen more often in carprofen-treated than DNP-treated or control colon. Tempol pretreatment resulted in more ruptured mitochondria in the carprofen-treated colon; however, other mitochondrial changes were not significantly affected by tempol pretreatment in either carprofen or DNP treated colon. Treatment with carprofen or DNP increased the mannitol flux, but pretreatment with tempol mitigated the carprofen effect. It is apparent that structural mitochondrial damage occurs in the canine colonic mucosa after carprofen and DNP exposure.

Role of p73 Dinucleotide Polymorphism in Prostate Cancer and p73 Protein Isoform Balance

Directory of Open Access Journals (Sweden)

L. Michael Carastro

2014-01-01

Full Text Available Background. Molecular markers for prostate cancer (PCa risks are currently lacking. Here we address the potential association of a dinucleotide polymorphism (DNP in exon 2 of the p73 gene with PCa risk/progression and discern any disruption of p73 protein isoforms levels in cells harboring a p73 DNP allele. Methods. We investigated the association between p73 DNP genotype and PCa risk/aggressiveness and survival by fitting logistic regression models in 1,292 incident cases and 682 controls. Results. Although we detected no association between p73 DNP and PCa risk, a significant inverse relationship between p73 DNP and PCa aggressiveness (AT/AT + GC/AT versus GC/GC, OR = 0.55, 95%Cl = 0.31–0.99 was detected. Also, p73 DNP is marginally associated with overall death (dominant model, HR = 0.76, 95%Cl = 0.57–1.00, P=0.053 as well as PCa specific death (HR = 0.69, 95%Cl = 0.45–1.06, P=0.09. Western blot analyses for p73 protein isoforms indicate that cells heterozygous for the p73 DNP have lower levels of ∆Np73 relative to TAp73 (P<0.001. Conclusions. Our findings are consistent with an association between p73 DNP and low risk for PCa aggressiveness by increasing the expressed TAp73/∆Np73 protein isoform ratio.

Dynamic nuclear polarization using frequency modulation at 3.34 T.

Science.gov (United States)

Hovav, Y; Feintuch, A; Vega, S; Goldfarb, D

2014-01-01

During dynamic nuclear polarization (DNP) experiments polarization is transferred from unpaired electrons to their neighboring nuclear spins, resulting in dramatic enhancement of the NMR signals. While in most cases this is achieved by continuous wave (cw) irradiation applied to samples in fixed external magnetic fields, here we show that DNP enhancement of static samples can improve by modulating the microwave (MW) frequency at a constant field of 3.34 T. The efficiency of triangular shaped modulation is explored by monitoring the (1)H signal enhancement in frozen solutions containing different TEMPOL radical concentrations at different temperatures. The optimal modulation parameters are examined experimentally and under the most favorable conditions a threefold enhancement is obtained with respect to constant frequency DNP in samples with low radical concentrations. The results are interpreted using numerical simulations on small spin systems. In particular, it is shown experimentally and explained theoretically that: (i) The optimal modulation frequency is higher than the electron spin-lattice relaxation rate. (ii) The optimal modulation amplitude must be smaller than the nuclear Larmor frequency and the EPR line-width, as expected. (iii) The MW frequencies corresponding to the enhancement maxima and minima are shifted away from one another when using frequency modulation, relative to the constant frequency experiments. Copyright © 2013 Elsevier Inc. All rights reserved.

Major results of the electron cyclotron heating experiment in the PDX tokamak

International Nuclear Information System (INIS)

Hsuan, H.; Bol, K.; Bowen, N.

1984-07-01

Electron Cyclotron Heating (ECH) experiments on PDX have been carried out with two 60 GHz pulsed gyrotrons each yielding up to approximately 100 kW. The ECH system used two waveguide runs each about 30 meters long. One run included 5 bends and the other, 7 bends. Predetermined waveguide modes were transmitted. The electron cyclotron waves were launched in narrow beams from both the high field and the low field sides of the plasma torus. The major new physics results are: (1) efficient central electron heating for both ohmic and neutral beam heated target plasmas; (2) alteration of MHD behavior using ECH; (3) identification of the trapped electron population with ECH; and (4) signature of velocity-space time evolution during ECH. In the best heating results obtained, Thomson scattering data indicated a central temperature increase from less than or equal to 1.5 keV to greater than or equal to 2.5 keV. This occurred with an average density of about 10 13 cm -3 and approximately 80 kW outside-launch ordinary-mode heating

Investigating the Tolerance of Tomato (Lycopersicon esculentum Cultivars to Broomrape (Orobanche aegyptiaca pers in Khorassan Razavi

Directory of Open Access Journals (Sweden)

M. Zafarian,

2014-03-01

Full Text Available To investigate the tolerance of tomato cultivars to Egyptian broomrape (Orobanche aegyptiaca pers., an experiment was conducted in a randomized complete block design with 11 treatments and 3 replications in mazrae Nemoune Astan Quds Razavi in Mashhad, Iran, 2012. Treatment were 11 varieties (Peto early CH, Sterling (Karon, Khorram, Petorak, DNP 3005, PS 6515, SPEEDY, IDEN, VADI STAR, FIRINZEH and DNP 3001 which were transplanted in the field along with broomrape. Sampling was done at two stages: 1- after appearance and establishment of broomrape on tomato root where the dry weight, stem number and node numbers of broomrape on tomato root and tomato dry weight were measured and 2- at the end of growing season where tomato fruit weight and its yield were determined. Result indicated that Sterling and Khorram cultivars did have the least broomrape dry weight, stem number and node numbers of broomrape on tomato root and while produced highest plant dry weight, fruit and yield as compared to the other cultivars. Thus, may be considered as tolerant cultivars. Petorak and DNP 3001 on the other hand, presented the most broomrape dry weight, stem number and node number on tomato root. However, Petorak, Peto early CH and FIRINZEH cultivars produced the least plant weight, fruit and yield and thus, they can be called the sensitive cultivars. DNP 3001 being highly attacked by broomrape produced increased fruit yield and therefore compensated its ill effects.

Annual Progress Report on Contract AFOSR-81-0093, March 15, 1984 to March 14, 1985,

Science.gov (United States)

1985-04-30

pulsar period. A recent development in pulsars was the observation of a pulsar outside our galaxy in the large { ( Magellanic cloud , with a period of 0.9...gyrotrons and other cyclotron masers. A. Goldenberg of the USSR gave a survey paper on gyrotron research in the USSR. He is from the city of Gorky...gas at 1 atmosphere, the purpose of which was not specified. G. L. Granatstein of the Naval Research Laboratory then gave a paper on Gyrotron and other

Approaches to a markedly increased sensitivity of the radioimmunoassay for thyrotropin-releasing hormone by derivatization

Energy Technology Data Exchange (ETDEWEB)

Visser, T J; Klootwijk, W [Erasmus Universiteit, Rotterdam (Netherlands). Dept. of Internal Medicine 3 and Clinical Endocrinology

1981-04-03

Studies on the specificity of the antisera obtained suggested that the sensitivity of the radioimmunoassay for TRH may be increased substantially by prior conversion of the hormone into dinitrophenylene derivatives. To test this possibility, several TRH-Dnp derivatives were prepared by reaction of TRH with equimolar amounts of 1,5-difluoro-2,4-dinitrobenzene yielding N/sup im/-(5-fluoro-2,4-dinitrophenyl)TRH. This intermediate was reacted with ammonia, histamine, tyramine or N/sup ..cap alpha../-acetyl-lysine methyl ester (N/sup ..cap alpha../Ac-LysOMe) to yield the respective unsubstituted and N-substituted N/sup im/-(5-amino-2,4-dinitrophenyl)TRH derivatives: TRH-Dnp-NH/sub 2/, TRH-Dnp-histamine, TRH-Dnp-tyramine and TRH-Dnp-N/sup ..cap alpha../Ac-Lys-OMe. N/sup im/-(2,4-Dinitrophenyl)TRH was prepared similarly by reaction of TRH with 1-fluoro-2,4-dinitrobenzene. The products were isolated by means of high-performance liquid chromatography (HPLC) and were found to be pure by HPLC and thin-layer chromatography using several solvent systems. TRH-Dnp-histamine and TRH-Dnp-tyramine were labelled with /sup 125/I using the chloramine-T method. The labelled products were purified to homogeneity by ion-exchange chromography on SP-Sephadex and adsorption chromatography on Sephadex LH-20, respectively, and were found by HPLC to be pure.

ECH Technology Development

Energy Technology Data Exchange (ETDEWEB)

Temkin, Richard [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

2014-12-24

Electron Cyclotron Heating (ECH) is needed for plasma heating, current drive, plasma stability control, and other applications in fusion energy sciences research. The program of fusion energy sciences supported by U. S. DOE, Office of Science, Fusion Energy Sciences relies on the development of ECH technology to meet the needs of several plasma devices working at the frontier of fusion energy sciences research. The largest operating ECH system in the world is at DIII-D, consisting of six 1 MW, 110 GHz gyrotrons capable of ten second pulsed operation, plus two newer gyrotrons. The ECH Technology Development research program investigated the options for upgrading the DIII-D 110 GHz ECH system. Options included extending present-day 1 MW technology to 1.3 – 1.5 MW power levels or developing an entirely new approach to achieve up to 2 MW of power per gyrotron. The research consisted of theoretical research and designs conducted by Communication and Power Industries of Palo Alto, CA working with MIT. Results of the study would be validated in a later phase by research on short pulse length gyrotrons at MIT and long pulse / cw gyrotrons in industry. This research follows a highly successful program of development that has led to the highly reliable, six megawatt ECH system at the DIII-D tokamak. Eventually, gyrotrons at the 1.5 megawatt to multi-megawatt power level will be needed for heating and current drive in large scale plasmas including ITER and DEMO.

An Academic-Practice Partnership Model to Grow and Sustain Advanced Practice Nursing.

Science.gov (United States)

Williams, Tracy E; Howard, Patricia B

2017-12-01

The aims of this article were to describe the implementation of an academic-practice partnership for healthcare system workforce development and provide preliminary outcomes of the associated pilot study. The demand for cross-continuum healthcare delivery models necessitates creation of workforce development structures for advanced practice nursing. An academic-practice partnership specified enrollment of 5 cohorts of BSN staff nurses in a 3-year DNP program. Qualitative methods were used to explore pilot data at midpoint of cohort 1 student progression to determine learning outcomes and DNP projects with potential for impact on organization goals. Partnership implementation experiences indicate that contractual agreements and an established evaluation plan are keys to academic-practice partnership success. Pilot study findings suggest that curriculum core courses provide a foundation for designing DNP projects congruent with acute and primary care health system goals. Implementing an academic-practice partnership is a strategy for workforce development to increase retention of advanced practice nurses. Academic-practice partnerships can serve as a catalyst for a paradigm shift for changing models of care, thus enhancing workforce development succession planning for sustainable growth in healthcare systems.

Low-temperature dynamic nuclear polarization with helium-cooled samples and nitrogen-driven magic-angle spinning.

Science.gov (United States)

Thurber, Kent; Tycko, Robert

2016-03-01

We describe novel instrumentation for low-temperature solid state nuclear magnetic resonance (NMR) with dynamic nuclear polarization (DNP) and magic-angle spinning (MAS), focusing on aspects of this instrumentation that have not been described in detail in previous publications. We characterize the performance of an extended interaction oscillator (EIO) microwave source, operating near 264 GHz with 1.5 W output power, which we use in conjunction with a quasi-optical microwave polarizing system and a MAS NMR probe that employs liquid helium for sample cooling and nitrogen gas for sample spinning. Enhancement factors for cross-polarized (13)C NMR signals in the 100-200 range are demonstrated with DNP at 25K. The dependences of signal amplitudes on sample temperature, as well as microwave power, polarization, and frequency, are presented. We show that sample temperatures below 30K can be achieved with helium consumption rates below 1.3 l/h. To illustrate potential applications of this instrumentation in structural studies of biochemical systems, we compare results from low-temperature DNP experiments on a calmodulin-binding peptide in its free and bound states. Published by Elsevier Inc.

THz-waves channeling in a monolithic saddle-coil for Dynamic Nuclear Polarization enhanced NMR

Science.gov (United States)

Macor, A.; de Rijk, E.; Annino, G.; Alberti, S.; Ansermet, J.-Ph.

2011-10-01

A saddle coil manufactured by electric discharge machining (EDM) from a solid piece of copper has recently been realized at EPFL for Dynamic Nuclear Polarization enhanced Nuclear Magnetic Resonance experiments (DNP-NMR) at 9.4 T. The corresponding electromagnetic behavior of radio-frequency (400 MHz) and THz (263 GHz) waves were studied by numerical simulation in various measurement configurations. Moreover, we present an experimental method by which the results of the THz-wave numerical modeling are validated. On the basis of the good agreement between numerical and experimental results, we conducted by numerical simulation a systematic analysis on the influence of the coil geometry and of the sample properties on the THz-wave field, which is crucial in view of the optimization of DNP-NMR in solids.

Many-body kinetics of dynamic nuclear polarization by the cross effect

Science.gov (United States)

Karabanov, A.; Wiśniewski, D.; Raimondi, F.; Lesanovsky, I.; Köckenberger, W.

2018-03-01

Dynamic nuclear polarization (DNP) is an out-of-equilibrium method for generating nonthermal spin polarization which provides large signal enhancements in modern diagnostic methods based on nuclear magnetic resonance. A particular instance is cross-effect DNP, which involves the interaction of two coupled electrons with the nuclear spin ensemble. Here we develop a theory for this important DNP mechanism and show that the nonequilibrium nuclear polarization buildup is effectively driven by three-body incoherent Markovian dissipative processes involving simultaneous state changes of two electrons and one nucleus. We identify different parameter regimes for effective polarization transfer and discuss under which conditions the polarization dynamics can be simulated by classical kinetic Monte Carlo methods. Our theoretical approach allows simulations of the polarization dynamics on an individual spin level for ensembles consisting of hundreds of nuclear spins. The insight obtained by these simulations can be used to find optimal experimental conditions for cross-effect DNP and to design tailored radical systems that provide optimal DNP efficiency.

Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear Polarization-Enhanced NMR Spectroscopy.

Science.gov (United States)

Viger-Gravel, Jasmine; Schantz, Anna; Pinon, Arthur C; Rossini, Aaron J; Schantz, Staffan; Emsley, Lyndon

2018-02-22

Here, we show how dynamic nuclear polarization (DNP) NMR spectroscopy experiments permit the atomic level structural characterization of loaded and empty lipid nanoparticles (LNPs). The LNPs used here were synthesized by the microfluidic mixing technique and are composed of ionizable cationic lipid (DLin-MC3-DMA), a phospholipid (distearoylphosphatidylcholine, DSPC), cholesterol, and poly(ethylene glycol) (PEG) (dimyristoyl phosphatidyl ethanolamine (DMPE)-PEG 2000), as well as encapsulated cargoes that are either phosphorothioated siRNA (50 or 100%) or mRNA. We show that LNPs form physically stable complexes with bioactive drug siRNA for a period of 94 days. Relayed DNP experiments are performed to study 1 H- 1 H spin diffusion and to determine the spatial location of the various components of the LNP by studying the average enhancement factors as a function of polarization time. We observe a striking feature of LNPs in the presence and in the absence of encapsulating siRNA or mRNA by comparing our experimental results to numerical spin-diffusion modeling. We observe that LNPs form a layered structure, and we detect that DSPC and DMPE-PEG 2000 lipids form a surface rich layer in the presence (or absence) of the cargoes and that the cholesterol and ionizable cationic lipid are embedded in the core. Furthermore, relayed DNP 31 P solid-state NMR experiments allow the location of the cargo encapsulated in the LNPs to be determined. On the basis of the results, we propose a new structural model for the LNPs that features a homogeneous core with a tendency for layering of DSPC and DMPE-PEG at the surface.

Development of EC technology in JAERI

International Nuclear Information System (INIS)

Sakamoto, Keishi; Takahashi, Koji; Kasugai, Atsushi; Hayashi, Kenichi; Ikeda, Yoshitaka; Kajiwara, Ken; Fujii, Tsuneyuki; Imai, Tsuyoshi; Kariya, Tsuyoshi; Mitsunaka, Yoshika

2003-01-01

Recent progress of electron cyclotron (EC) heating and current drive technologies in JAERI is reported. In 170 GHz gyrotron development, 0.9 MW/9.2 sec (efficiency: 43%), 0.5 MW/30 sec (46%), etc, have been demonstrated. As for 110 GHz gyrotron, 1 MW/5 sec and 1.2 MW/4.1 sec were obtained. Using four 110 GHz gyrotrons, a 3 MW power injection into JT- 60U plasma was carried out. In parallel, a launcher design and its development that includes neutron irradiation of the launcher components and a remote steering launcher are underway for ITER application. (authors)

Overhauser effects in insulating solids

NARCIS (Netherlands)

Can, T. V.; Caporini, M. A.; Mentink-Vigier, F.; Corzilius, B.; Walish, J. J.; Rosay, M.; Maas, W. E.; Baldus, M.|info:eu-repo/dai/nl/314410864; Vega, S.; Swager, T. M.; Griffin, R. G.

2014-01-01

We report magic angle spinning, dynamic nuclear polarization (DNP) experiments at magnetic fields of 9.4 T, 14.1 T, and 18.8 T using the narrow line polarizing agents 1,3-bisdiphenylene-2-phenylallyl (BDPA) dispersed in polystyrene, and sulfonated-BDPA (SA-BDPA) and trityl OX063 in glassy

Decomposition of nuclear chromatin of the rat thymus within the postirradiation period

International Nuclear Information System (INIS)

Vodolazskaya, N.A.

1975-01-01

Fractional composition of DNP histones and of salt extracts of the thymus of rats has been studied 2 to 8 hours after γ-irradiation with 600r (Co 60 ). Simultaneously, histones/DNA ratio has been determined in the nucleoprotein and in its salt-soluble fragments after fractionation of the salt extracts on phosphatecellulose. It has been shown that 2 to 4 hours following the exposure, the histone/DNA ratio in DNP preparations does not vary from the control. Subsequently, however, it slightly decreases. It has been found that the postirradiation DNP decomposition is accompanied by the formation of fragments which, in addition to a free DNA, comprise complexes with the decreased and increased histone/DNA ratio as compared to the original DNP

Melanoma Vaccine--AVAX Technologies: DNP-VACC, M-Vax.

Science.gov (United States)

2003-01-01

Adis CommentsAVAX Technologies is developing a therapeutic melanoma vaccine [M-Vax, DNP-VACC] consisting of autologous tumour cells conjugated to a highly immunogenic hapten, dinitrophenyl, which makes the cancer cells more easily recognised by the immune system. AVAX licensed the autologous cell vaccine technology (AC Vaccine) from Thomas Jefferson University in Philadelphia, USA, where it was originally developed. M-Vax was launched in Australia in the first half of 2000, but was withdrawn from this market in September 2002 due to financial constraints faced by the company and its need to focus its resources on initiatives that provide the greatest return. Although AVAX applied for Federal Government price reimbursement in Australia through the Medical Services Advisory Committee during 2001, the vaccine is not reimbursed in Australia. Obtaining Federal Government reimbursement was a step AVAX considered essential for the success of the M-Vax. AVAX has not ruled out re-entering the Australian market again at a later date. AVAX will now concentrate on gaining approval in the US and Europe. M-Vax has received orphan drug designation from the US FDA. M-Vax is in preregistration in Germany, Japan and The Netherlands for treatment of stage III melanoma. In September 1999, the company announced that it expected to market M-Vax for treatment of stage III melanoma in Germany, Japan and the Netherlands. This announcement came after AVAX's continuing dialogue with senior regulatory authorities in several pharmaceutical markets. The commercial availability of M-Vax in Germany, Japan and The Netherlands will be subject to meeting certain requirements specified by the regulatory agency in each country. Phase II data have been submitted for regulatory approval in these countries; phase III data may not be required because the vaccine contains autologous tumour cells. This was the case with the Australian approval of M-Vax, which was on the basis of data from phase II trials

Carbon Nanofiber/3D Nanoporous Silicon Hybrids as High Capacity Lithium Storage Materials.

Science.gov (United States)

Park, Hyeong-Il; Sohn, Myungbeom; Kim, Dae Sik; Park, Cheolho; Choi, Jeong-Hee; Kim, Hansu

2016-04-21

Carbon nanofiber (CNF)/3D nanoporous (3DNP) Si hybrid materials were prepared by chemical etching of melt-spun Si/Al-Cu-Fe alloy nanocomposites, followed by carbonization using a pitch. CNFs were successfully grown on the surface of 3DNP Si particles using residual Fe impurities after acidic etching, which acted as a catalyst for the growth of CNFs. The resulting CNF/3DNP Si hybrid materials showed an enhanced cycle performance up to 100 cycles compared to that of the pristine Si/Al-Cu-Fe alloy nanocomposite as well as that of bare 3DNP Si particles. These results indicate that CNFs and the carbon coating layer have a beneficial effect on the capacity retention characteristics of 3DNP Si particles by providing continuous electron-conduction pathways in the electrode during cycling. The approach presented here provides another way to improve the electrochemical performances of porous Si-based high capacity anode materials for lithium-ion batteries. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Recycling and imaging of nuclear singlet hyperpolarization

DEFF Research Database (Denmark)

Pileio, Giuseppe; Bowen, Sean; Laustsen, Christoffer

2013-01-01

observation of the same batch of polarized nuclei over a period of 30 min and more. We report a recycling protocol in which the enhanced nuclear polarization achieved by dissolution-DNP is observed with full intensity and then returned to singlet order. MRI experiments may be run on a portion of the available...

Being in control? A thematic content analysis of 14 in-depth interviews with 2,4-dinitrophenol users.

Science.gov (United States)

Ainsworth, Neha Prasad; Vargo, Elisabeth Julie; Petróczi, Andrea

2018-02-01

2,4-Dinitrophenol (2,4-DNP) is a compound with multiple industrial purposes. Currently unlicensed for human consumption, it is used by the gym-going population for drastic, short-term body fat loss. Nonetheless, physiological mechanisms can lead to potentially fatal hyperthermia. Reported fatal incidents have caused concern and highlighted the need for intervention. Understanding decision-making leading to 2,4-DNP use alongside the perceived outgroup attitudes is vital to forming effective harm minimisation policies targeting current and potential users. First-hand accounts from this elusive population are scarce. Fourteen novel and experienced users (13 male, 1 female) were recruited via "snowballing" techniques. Semi-structured interviews were conducted, comprising 28 questions. Thematic content analysis was conducted using 37 codes. Four characteristic themes emerged: 1. Users considered the Internet to be a crucial multifunctional resource directly impacting their 2,4-DNP use. 2. Users "respected" 2,4-DNP, proactively taking harm reduction measures. 3. Attitudinal polarisation towards 2,4-DNP within the gym-going community was consistent in all accounts. 4. Users perceived outgroup populations to have inherently negative attitudes towards their use. These themes fell under the all-encompassing theme of "being in control". For the first time, this study offers a rich detail of attitudes toward 2,4-DNP use by giving a collective voice to users. The element of control over every aspect of the users' life appears to be a significant contributor to the successful risk-management of 2,4-DNP use. In the absence of an established safe upper limit and effective regulatory control, education is critical to harm minimisation. Copyright © 2017 Elsevier B.V. All rights reserved.

Distribution of intravenously administered acetylcholinesterase inhibitor and acetylcholinesterase activity in the adrenal gland: 11C-donepezil PET study in the normal rat.

Science.gov (United States)

Watabe, Tadashi; Naka, Sadahiro; Ikeda, Hayato; Horitsugi, Genki; Kanai, Yasukazu; Isohashi, Kayako; Ishibashi, Mana; Kato, Hiroki; Shimosegawa, Eku; Watabe, Hiroshi; Hatazawa, Jun

2014-01-01

Acetylcholinesterase (AChE) inhibitors have been used for patients with Alzheimer's disease. However, its pharmacokinetics in non-target organs other than the brain has not been clarified yet. The purpose of this study was to evaluate the relationship between the whole-body distribution of intravenously administered (11)C-Donepezil (DNP) and the AChE activity in the normal rat, with special focus on the adrenal glands. The distribution of (11)C-DNP was investigated by PET/CT in 6 normal male Wistar rats (8 weeks old, body weight  = 220 ± 8.9 g). A 30-min dynamic scan was started simultaneously with an intravenous bolus injection of (11)C-DNP (45.0 ± 10.7 MBq). The whole-body distribution of the (11)C-DNP PET was evaluated based on the Vt (total distribution volume) by Logan-plot analysis. A fluorometric assay was performed to quantify the AChE activity in homogenized tissue solutions of the major organs. The PET analysis using Vt showed that the adrenal glands had the 2nd highest level of (11)C-DNP in the body (following the liver) (13.33 ± 1.08 and 19.43 ± 1.29 ml/cm(3), respectively), indicating that the distribution of (11)C-DNP was the highest in the adrenal glands, except for that in the excretory organs. The AChE activity was the third highest in the adrenal glands (following the small intestine and the stomach) (24.9 ± 1.6, 83.1 ± 3.0, and 38.5 ± 8.1 mU/mg, respectively), indicating high activity of AChE in the adrenal glands. We demonstrated the whole-body distribution of (11)C-DNP by PET and the AChE activity in the major organs by fluorometric assay in the normal rat. High accumulation of (11)C-DNP was observed in the adrenal glands, which suggested the risk of enhanced cholinergic synaptic transmission by the use of AChE inhibitors.

Aged dominant negative p38α MAPK mice are resistant to age-dependent decline in adult-neurogenesis and context discrimination fear conditioning.

Science.gov (United States)

Cortez, IbDanelo; Bulavin, Dmitry V; Wu, Ping; McGrath, Erica L; Cunningham, Kathryn A; Wakamiya, Maki; Papaconstantinou, John; Dineley, Kelly T

2017-03-30

A major aspect of mammalian aging is the decline in functional competence of many self-renewing cell types, including adult-born neuronal precursors. Since age-related senescence of self-renewal occurs simultaneously with chronic up-regulation of the p38MAPKalpha (p38α) signaling pathway, we used the dominant negative mouse model for attenuated p38α activity (DN-p38α AF/+ ) in which Thr180 and Tyr182 are mutated (T→A/Y→F) to prevent phosphorylation activation (DN-p38α AF/+ ) and kinase activity. As a result, aged DN-p38α AF/+ mice are resistant to age-dependent decline in proliferation and regeneration of several peripheral tissue progenitors when compared to wild-type littermates. Aging is the major risk factor for non-inherited forms of Alzheimer's disease (AD); environmental and genetic risk factors that accelerate the senescence phenotype are thought to contribute to an individual's relative risk. In the present study, we evaluated aged DN-p38α AF/+ and wildtype littermates in a series of behavioral paradigms to test if p38α mutant mice exhibit altered baseline abnormalities in neurological reflexes, locomotion, anxiety-like behavior, and age-dependent cognitive decline. While aged DN-p38α AF/+ and wildtype littermates appear equal in all tested baseline neurological and behavioral parameters, DN-p38α AF/+ exhibit superior context discrimination fear conditioning. Context discrimination is a cognitive task that is supported by proliferation and differentiation of adult-born neurons in the dentate gyrus of the hippocampus. Consistent with enhanced context discrimination in aged DN-p38α AF/+ , we discovered enhanced production of adult-born neurons in the dentate gyrus of DN-p38α AF/+ mice compared to wildtype littermates. Our findings support the notion that p38α inhibition has therapeutic utility in aging diseases that affect cognition, such as AD. Copyright © 2016 Elsevier B.V. All rights reserved.

Distribution of intravenously administered acetylcholinesterase inhibitor and acetylcholinesterase activity in the adrenal gland: 11C-donepezil PET study in the normal rat.

Directory of Open Access Journals (Sweden)

Tadashi Watabe

Full Text Available PURPOSE: Acetylcholinesterase (AChE inhibitors have been used for patients with Alzheimer's disease. However, its pharmacokinetics in non-target organs other than the brain has not been clarified yet. The purpose of this study was to evaluate the relationship between the whole-body distribution of intravenously administered (11C-Donepezil (DNP and the AChE activity in the normal rat, with special focus on the adrenal glands. METHODS: The distribution of (11C-DNP was investigated by PET/CT in 6 normal male Wistar rats (8 weeks old, body weight  = 220 ± 8.9 g. A 30-min dynamic scan was started simultaneously with an intravenous bolus injection of (11C-DNP (45.0 ± 10.7 MBq. The whole-body distribution of the (11C-DNP PET was evaluated based on the Vt (total distribution volume by Logan-plot analysis. A fluorometric assay was performed to quantify the AChE activity in homogenized tissue solutions of the major organs. RESULTS: The PET analysis using Vt showed that the adrenal glands had the 2nd highest level of (11C-DNP in the body (following the liver (13.33 ± 1.08 and 19.43 ± 1.29 ml/cm(3, respectively, indicating that the distribution of (11C-DNP was the highest in the adrenal glands, except for that in the excretory organs. The AChE activity was the third highest in the adrenal glands (following the small intestine and the stomach (24.9 ± 1.6, 83.1 ± 3.0, and 38.5 ± 8.1 mU/mg, respectively, indicating high activity of AChE in the adrenal glands. CONCLUSIONS: We demonstrated the whole-body distribution of (11C-DNP by PET and the AChE activity in the major organs by fluorometric assay in the normal rat. High accumulation of (11C-DNP was observed in the adrenal glands, which suggested the risk of enhanced cholinergic synaptic transmission by the use of AChE inhibitors.

Research on nuclear fusion reactor - Development of mm-wve (Electron cyclotron) heating device

Energy Technology Data Exchange (ETDEWEB)

Ahn, Sae Young; Myung, Jung Su; Lee, Keun Ho; Lee, Myung Jae; Kim, Hyung Suk; Hur, Jin Woo; Song, Ho Young [Institute for Advanced Engineering, Seoul (Korea, Republic of)

1996-08-01

To establish cooperating system with foreign relevant research institutes, consultation has been given to IAE by Dr. T. V. George regarding ECRH and gyrotron development plan. Discussions with Prof. Temkin and Dr. Kreisher at MIT, who are working for ITER gyrotron development, were made and those helped IAE to collect necessary information for fundamental parameters of ECCD. Also, Prof. Vic Granatstein, U. of Maryland, and Dr. Baruch Levush, NRL, were consulted for computer codes of the gyrotron R and D. It will also be prepared for cooperation in ECCD and mm-wave heating with device research teams of General Atomics and Russia. By visiting various University labs and research institutes and investigating the up-to-date research results, the basic operating parameters of gyrotron for KSTAR project has been determined. By cooperation with MIT, a conceptual design has been made for the KSTAR gyrotron that should generate 1 MW and 110 GHz CW waves. The simulation result of EGUN using self-consistent theory shows that 1.2 MW power with the efficiency of 42.8% can be obtained for TE22,6,1 mode where the average ohmic loss is 0.54 kW/cm{sup 2} assuming 77 kV cathode voltage, 34 A beam current, velocity ratio of 1.62 and perpendicular velocity spread of 6.5%. 9 refs., 5 figs., 3 tabs. (author)

Investigation on heat transfer analysis and its effect on a multi-mode, beam-wave interaction for a 140 GHz, MW-class gyrotron

Science.gov (United States)

Liu, Qiao; Liu, Yinghui; Chen, Zhaowei; Niu, Xinjian; Li, Hongfu; Xu, Jianhua

2018-04-01

The interaction cavity of a 140 GHz, 1 MW continuous wave gyrotron developed in UESTC will be loaded with a very large heat load in the inner surface during operation. In order to reduce the heat, the axial wedge grooves of the outside surface of the cavity are considered and employed as the heat radiation structure. Thermoanalysis and structural analysis were discussed in detail to obtain the effects of heat on the cavity. In thermoanalysis, the external coolant-flow rates ranging from 20 L/min to 50 L/min were considered, and the distribution of wall loading was loaded as the heat flux source. In structural analysis, the cavity's deformation caused by the loads of heat and pressure was calculated. Compared with a non-deformed cavity, the effects of deformation on the performance of a cavity were discussed. For a cold-cavity, the results show that the quality factor would be reduced by 72, 89, 99 and 171 at the flow rates of 50 L/min, 40 L/min, 30 L/min and 20 L/min, respectively. Correspondingly, the cold-cavity frequencies would be decreased by 0.13 GHz, 0.15 GHz, 0.19 GHz and 0.38 GHz, respectively. For a hot-cavity, the results demonstrate that the output port frequencies would be dropped down, but the offset would be gradually decreased with increasing coolant-flow rate. Meanwhile, the output powers would be reduced dramatically with decreasing coolant-flow rate. In addition, when the coolant-flow rate reaches 40 L/min, the output power and the frequency are just reduced by 30 kW and 0.151 GHz, respectively.

Multiple acquisition of magic angle spinning solid-state NMR experiments using one receiver: Application to microcrystalline and membrane protein preparations

Science.gov (United States)

Gopinath, T.; Veglia, Gianluigi

2015-04-01

Solid-state NMR spectroscopy of proteins is a notoriously low-throughput technique. Relatively low-sensitivity and poor resolution of protein samples require long acquisition times for multidimensional NMR experiments. To speed up data acquisition, we developed a family of experiments called Polarization Optimized Experiments (POE), in which we utilized the orphan spin operators that are discarded in classical multidimensional NMR experiments, recovering them to allow simultaneous acquisition of multiple 2D and 3D experiments, all while using conventional probes with spectrometers equipped with one receiver. POE allow the concatenation of multiple 2D or 3D pulse sequences into a single experiment, thus potentially combining all of the aforementioned advances, boosting the capability of ssNMR spectrometers at least two-fold without the addition of any hardware. In this perspective, we describe the first generation of POE, such as dual acquisition MAS (or DUMAS) methods, and then illustrate the evolution of these experiments into MEIOSIS, a method that enables the simultaneous acquisition of multiple 2D and 3D spectra. Using these new pulse schemes for the solid-state NMR investigation of biopolymers makes it possible to obtain sequential resonance assignments, as well as distance restraints, in about half the experimental time. While designed for acquisition of heteronuclei, these new experiments can be easily implemented for proton detection and coupled with other recent advancements, such as dynamic nuclear polarization (DNP), to improve signal to noise. Finally, we illustrate the application of these methods to microcrystalline protein preparations as well as single and multi-span membrane proteins reconstituted in lipid membranes.

Architecture of central control system for the 10 MW ECRH-plant at W7-X

Energy Technology Data Exchange (ETDEWEB)

Braune, H. [Max-Plank-Institut fuer Plasmaphysik, Euratom Association Teilinstitut Greifswald, Wendelsteinstrasse 1, D-17491 Greifswald (Germany)], E-mail: harald.braune@ipp.mpg.de; Brand, P. [Universitaet Stuttgart, Institut fuer Plasmaforschung Pfaffenwaldring 31, D-70569 Stuttgart (Germany); Erckmann, V.; Jonitz, L. [Max-Plank-Institut fuer Plasmaphysik, Euratom Association Teilinstitut Greifswald, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Leonhardt, W.; Mellein, D. [Forschungszentrum Karlsruhe, Association EURATOM-FZK, IHM, FZK, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Michel, G. [Max-Plank-Institut fuer Plasmaphysik, Euratom Association Teilinstitut Greifswald, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Mueller, G. [Universitaet Stuttgart, Institut fuer Plasmaforschung Pfaffenwaldring 31, D-70569 Stuttgart (Germany); Purps, F. [Max-Plank-Institut fuer Plasmaphysik, Euratom Association Teilinstitut Greifswald, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Schlueter, K.-H. [Universitaet Stuttgart, Institut fuer Plasmaforschung Pfaffenwaldring 31, D-70569 Stuttgart (Germany); Winkler, M. [Max-Plank-Institut fuer Plasmaphysik, Euratom Association Teilinstitut Greifswald, Wendelsteinstrasse 1, D-17491 Greifswald (Germany)

2007-10-15

Electron Cyclotron Resonance Heating (ECRH) is the main heating method for the Wendelstein 7-X stellarator (W7-X) which is presently under construction at IPP Greifswald. The mission of W7-X is to demonstrate the inherent steady state capability of stellarators at reactor relevant plasma parameters. A modular 10 MW ECRH-plant at 140 GHz with 1 MW CW-capability power for each module is also under construction to support the scientific objectives. The commissioning of the ECRH-plant is well under way; three gyrotrons are operational. The strict modular design allows to operate each gyrotron separately and independent from all others. The ECRH-plant consists of many devices such as gyrotrons and high voltage power supplies, superconductive magnets, collector sweep coils, gyrotron cooling systems with many water circuits and last but not least the quasi-optical transmission line for microwaves with remote controlled mirrors and further water cooled circuits. All these devices are essential for a CW operation. A steady state ECRH has specific requirements on the stellarator machine itself, on the microwave sources, transmission elements and in particular on the central control system. The quasi steady state operation (up to 30 min) asks for real time microwave power adjustment during the different segments of one stellarator discharge. Therefore, the ECRH-plant must operate with a maximum reliability and availability. A capable central control system is an important condition to achieve this goal. The central control system for the 10 MW ECRH-plant at W7-X comprises three main parts. In detail these are the voltage and current regulation of each gyrotron, the interlock system to prevent the gyrotrons from damages and the remote control system based on a hierarchy set of PLCs and computers. The architecture of this central control system is presented.

Functional antigen binding by the defective B cells of CBA/N mice.

Science.gov (United States)

Snippe, H; Merchant, B; Lizzio, E F; Inman, J K

1982-01-01

CBA/N mice have an X-linked B cell defect which prevents them from responding to nonmitogenic thymic independent (TI-2) antigens such as dinitrophenylated DNP-Ficoll (1,2). The F1 male progeny of CBA/N female mice express the same defect. Spleen cell suspensions from such defective mice (CBA/N X C3H/HeN F1 males) could not respond to DNP-Ficoll following in vitro immunization and subsequent transfer into irradiated, syngeneic, F1 male recipients as expected. In contrast, normal CBA/N X C3H/HeN F1 female spleen cells could respond and effect a "rescue"; they mounted strong plaque-forming cell responses 7 days after in vitro exposure to DNP-Ficoll and subsequent transfer into irradiated F1 male recipients. Defective F1 male spleen cells, however, could bind significant quantities of 125I-DNP-Ficoll after in vitro exposure. Extensive washing of these spleen cells could not reverse this binding. Such DNP-Ficoll-exposed and washed F1 male spleen cells could, after transfer, aid normal untreated F1 female cells in their rescue function. The defective F1 male spleen cells could convey immunogenic quantities of DNP-Ficoll to the "rescuing" F1 female cells. Mitomycin treatment of F1 male cells did not interfere with their conveyor function. Goat anti-mouse mu serum impeded the passive antigen conveyor function of defective F1 male cells as did prior exposure to high concentrations of free DNP hapten. Our data support the view that the B cell defect of CBA/N X C3H/HeN F1 male mice does not relate to antigen binding, but rather to an inability to be effectively triggered by certain cell-bound polymeric antigens.

Activated microglia in the spinal cord underlies diabetic neuropathic pain.

Science.gov (United States)

Wang, Dongmei; Couture, Réjean; Hong, Yanguo

2014-04-05

Diabetes mellitus is an increasingly common chronic medical condition. Approximately 30% of diabetic patients develop neuropathic pain, manifested as spontaneous pain, hyperalgesia and allodynia. Hyperglycemia induces metabolic changes in peripheral tissues and enhances oxidative stress in nerve fibers. The damages and subsequent reactive inflammation affect structural properties of Schwann cells and axons leading to the release of neuropoietic mediators, such as pro-inflammatory cytokines and pro-nociceptive mediators. Therefore, diabetic neuropathic pain (DNP) shares some histological features and underlying mechanisms with traumatic neuropathy. DNP displays, however, other distinct features; for instance, sensory input to the spinal cord decreases rather than increasing in diabetic patients. Consequently, development of central sensitization in DNP involves mechanisms that are distinct from traumatic neuropathic pain. In DNP, the contribution of spinal cord microglia activation to central sensitization and pain processes is emerging as a new concept. Besides inflammation in the periphery, hyperglycemia and the resulting production of reactive oxygen species affect the local microenvironment in the spinal cord. All these alterations could trigger resting and sessile microglia to the activated phenotype. In turn, microglia synthesize and release pro-inflammatory cytokines and neuroactive molecules capable of inducing hyperactivity of spinal nociceptive neurons. Hence, it is imperative to elucidate glial mechanisms underlying DNP for the development of effective therapeutic agents. The present review highlights the recent developments regarding the contribution of spinal microglia as compelling target for the treatment of DNP. Copyright © 2014 Elsevier B.V. All rights reserved.

Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy.

Directory of Open Access Journals (Sweden)

Katalin Susztak

2005-02-01

Full Text Available Diabetic nephropathy (DNP is a common complication of type 1 and type 2 diabetes mellitus and the most common cause of kidney failure. While DNP manifests with albuminuria and diabetic glomerulopathy, its progression correlates best with tubular epithelial degeneration (TED and interstitial fibrosis. However, mechanisms leading to TED in DNP remain poorly understood.We found that expression of scavenger receptor CD36 coincided with proximal tubular epithelial cell (PTEC apoptosis and TED specifically in human DNP. High glucose stimulated cell surface expression of CD36 in PTECs. CD36 expression was necessary and sufficient to mediate PTEC apoptosis induced by glycated albumins (AGE-BSA and CML-BSA and free fatty acid palmitate through sequential activation of src kinase, and proapoptotic p38 MAPK and caspase 3. In contrast, paucity of expression of CD36 in PTECs in diabetic mice with diabetic glomerulopathy was associated with normal tubular epithelium and the absence of tubular apoptosis. Mouse PTECs lacked CD36 and were resistant to AGE-BSA-induced apoptosis. Recombinant expression of CD36 in mouse PTECs conferred susceptibility to AGE-BSA-induced apoptosis.Our findings suggest a novel role for CD36 as an essential mediator of proximal tubular apoptosis in human DNP. Because CD36 expression was induced by glucose in PTECs, and because increased CD36 mediated AGE-BSA-, CML-BSA-, and palmitate-induced PTEC apoptosis, we propose a two-step metabolic hit model for TED, a hallmark of progression in DNP.

Choroidal thickness alterations in diabetic nephropathy patients with early or no diabetic retinopathy.

Science.gov (United States)

Kocasarac, Can; Yigit, Yavuz; Sengul, Erkan; Sakalar, Yildirim Beyazit

2018-04-01

To assess changes in choroidal thickness (CT) in diabetes patients with and without diabetic nephropathy using enhanced depth imaging spectral domain optical coherence tomography (EDI-OCT). Thirty-five type 2 diabetes patients with a diagnosis of diabetic nephropathy (DNP) in nephrology department and 35 type 2 diabetes patients without nephropathy (non-DNP) were included in our prospective study consecutively. The control group comprised 34 healthy individuals. CT measurements were recorded under the fovea and at 1500 µm from the foveal center in the nasal and temporal sides. The study parameters also included age, refractive error, axial length, intraocular pressure, HbA1c, glomerular filtration rate and proteinuria amount. The subfoveal, temporal and nasal choroidal thickness was noted to be thinner in patients with DNP compared with non-DNP and normal subjects (p diabetic patients when diabetic nephropathy accompanies diabetes mellitus.

Development of two series ingnitron based crowbar protection system for 42 GHz and 82.6 GHz gyroton in SST-1

International Nuclear Information System (INIS)

Dhorajiya, Pragnesh; Dalakoti, Shefali; Patel, Harshida; Ingle, Krunal; Patel, Jatin; Sathyanarayana, K.; Rajanbabu; Shukla, B.K.

2013-01-01

Gyrotrons are used to generate the high power at microwave frequency that is used to heat the plasma inside a Tokamak. A conventional high voltage power supply is used for the testing of 82.6 GHz, 200 kW/CW and 42 GHz, 500 kW/500ms gyrotrons at our institute. Its maximum operating cathode parameters are -55 kV DC, 20 A. Like any other High RF power tubes gyrotrons need to be protected against arc faults within the tube. If the energy dumped in such arc fault is more than the critical crater energy of the tube, irreparable damage can occur inside the RF tube or microwave tube and rendering it useless. The specified maximum fault energy for the 42 GHz and 82.6 GHz gyrotrons is 10 joules. When conventional HVDC power supplies feed high power RF tubes or microwave tubes, a reliable crowbar protection is required which is tested separately to limit the energy to the tube in case of any type of fault to assure the tube safety. Two series ignitron (NL-37248) based crowbar system developed in-house is used to limit the arc fault energy under the acceptance level by diverting the fault current from the load or Gyrotron. Fault current diversion and interruption are initiated by the sensing element and protection system. The required protection cards are designed and developed in-house and required performance is achieved. With this crowbar system the high voltage switch-off to the gyrotron is achieved within 5 μsec after occurrence of critical faults. The crowbar is tested for voltage hold-off up to 80 kV DC. This paper presents the critical requirement of the time delay for the fault sensing and crowbar trigger generation and necessary protections that are incorporated with the ignitron switch crowbar like over voltage, pulsed over current and continuous over current. The crowbar system developed in-house, tested at rated value. The results obtained during the stand-alone tests and commissioning tests are also mentioned. Using this crowbar system the high voltage power

Doctor of Nursing Practice: The Role of the Advanced Practice Nurse.

Science.gov (United States)

Walker, Deborah Kirk; Polancich, Shea

2015-11-01

To explore the evolution and emerging roles of the Doctor of Nursing Practice (DNP) Advanced Practice Nurse (APN). Published peer reviewed literature, cancer-related professional resources, and Web-based resources. The DNP education has prepared the APN for process improvement initiatives, providing quality care, and evidence-based practice translation, which are critical with the emerging trends in this complex health care environment. DNP-prepared APNs have the opportunity to impact oncology care across the cancer trajectory, in various settings, and in various innovative roles as entrepreneurs. Copyright © 2015 Elsevier Inc. All rights reserved.

The ethics curriculum for doctor of nursing practice programs.

Science.gov (United States)

Peirce, Anne Griswold; Smith, Jennifer A

2008-01-01

Ethical questions dealt with by nurses who have Doctor of Nursing Practice (DNP) degrees include traditional bioethical questions, but also business and legal ethics. Doctorally prepared nurses are increasingly in positions to make ethical decisions rather than to respond to decisions made by others. The traditional master's-degree advanced practice nursing curriculum does not address the extended expertise and decision-making skills needed by DNP practitioners as they face these new types of ethical dilemmas. We propose that a curricular framework that addresses clinical, research, business, and legal ethics is needed by all DNP students.

Initial results for a 170 GHz high power ITER waveguide component test stand

Science.gov (United States)

Bigelow, Timothy; Barker, Alan; Dukes, Carl; Killough, Stephen; Kaufman, Michael; White, John; Bell, Gary; Hanson, Greg; Rasmussen, Dave

2014-10-01

A high power microwave test stand is being setup at ORNL to enable prototype testing of 170 GHz cw waveguide components being developed for the ITER ECH system. The ITER ECH system will utilize 63.5 mm diameter evacuated corrugated waveguide and will have 24 >150 m long runs. A 170 GHz 1 MW class gyrotron is being developed by Communications and Power Industries and is nearing completion. A HVDC power supply, water-cooling and control system has been partially tested in preparation for arrival of the gyrotron. The power supply and water-cooling system are being designed to operate for >3600 second pulses to simulate the operating conditions planned for the ITER ECH system. The gyrotron Gaussian beam output has a single mirror for focusing into a 63.5 mm corrugated waveguide in the vertical plane. The output beam and mirror are enclosed in an evacuated duct with absorber for stray radiation. Beam alignment with the waveguide is a critical task so a combination of mirror tilt adjustments and a bellows for offsets will be provided. Analysis of thermal patterns on thin witness plates will provide gyrotron mode purity and waveguide coupling efficiency data. Pre-prototype waveguide components and two dummy loads are available for initial operational testing of the gyrotron. ORNL is managed by UT-Battelle, LLC, for the U.S. Dept. of Energy under Contract DE-AC-05-00OR22725.

A Comparison of the Democratic Security Policy in Colombia and Provincial Reconstruction Teams in Iraq

Science.gov (United States)

2009-09-01

program. Republica de Colombia. Departamento Nacional de Planeacion , Porgrama de Desarrollo Alternativo, Documento CONPES 2734-DNP-UDA-UJS, Bogotá...Ministry of Defense, 2003. Republica de Colombia. “Departmento Nacional de Planeacion , Porgrama de Desarrollo Alternativo, Documento CONPES 2734-DNP

Degradation of 2,4-dinitrophenol using a combination of hydrodynamic cavitation, chemical and advanced oxidation processes.

Science.gov (United States)

Bagal, Manisha V; Gogate, Parag R

2013-09-01

In the present work, degradation of 2,4-dinitrophenol (DNP), a persistent organic contaminant with high toxicity and very low biodegradability has been investigated using combination of hydrodynamic cavitation (HC) and chemical/advanced oxidation. The cavitating conditions have been generated using orifice plate as a cavitating device. Initially, the optimization of basic operating parameters have been done by performing experiments over varying inlet pressure (over the range of 3-6 bar), temperature (30 °C, 35 °C and 40 °C) and solution pH (over the range of 3-11). Subsequently, combined treatment strategies have been investigated for process intensification of the degradation process. The effect of HC combined with chemical oxidation processes such as hydrogen peroxide (HC/H2O2), ferrous activated persulfate (HC/Na2S2O8/FeSO4) and HC coupled with advanced oxidation processes such as conventional Fenton (HC/FeSO4/H2O2), advanced Fenton (HC/Fe/H2O2) and Fenton-like process (HC/CuO/H2O2) on the extent of degradation of DNP have also been investigated at optimized conditions of pH 4, temperature of 35 °C and inlet pressure of 4 bar. Kinetic study revealed that degradation of DNP fitted first order kinetics for all the approaches under investigation. Complete degradation with maximum rate of DNP degradation has been observed for the combined HC/Fenton process. The energy consumption analysis for hydrodynamic cavitation based process has been done on the basis of cavitational yield. Degradation intermediates have also been identified and quantified in the current work. The synergistic index calculated for all the combined processes indicates HC/Fenton process is more feasible than the combination of HC with other Fenton like processes. Copyright © 2013 Elsevier B.V. All rights reserved.

High-field Overhauser dynamic nuclear polarization in silicon below the metal-insulator transition.

Science.gov (United States)

Dementyev, Anatoly E; Cory, David G; Ramanathan, Chandrasekhar

2011-04-21

Single crystal silicon is an excellent system to explore dynamic nuclear polarization (DNP), as it exhibits a continuum of properties from metallic to insulating as a function of doping concentration and temperature. At low doping concentrations DNP has been observed to occur via the solid effect, while at very high-doping concentrations an Overhauser mechanism is responsible. Here we report the hyperpolarization of (29)Si in n-doped silicon crystals, with doping concentrations in the range of (1-3) × 10(17) cm(-3). In this regime exchange interactions between donors become extremely important. The sign of the enhancement in our experiments and its frequency dependence suggest that the (29)Si spins are directly polarized by donor electrons via an Overhauser mechanism within exchange-coupled donor clusters. The exchange interaction between donors only needs to be larger than the silicon hyperfine interaction (typically much smaller than the donor hyperfine coupling) to enable this Overhauser mechanism. Nuclear polarization enhancement is observed for a range of donor clusters in which the exchange energy is comparable to the donor hyperfine interaction. The DNP dynamics are characterized by a single exponential time constant that depends on the microwave power, indicating that the Overhauser mechanism is a rate-limiting step. Since only about 2% of the silicon nuclei are located within 1 Bohr radius of the donor electron, nuclear spin diffusion is important in transferring the polarization to all the spins. However, the spin-diffusion time is much shorter than the Overhauser time due to the relatively weak silicon hyperfine coupling strength. In a 2.35 T magnetic field at 1.1 K, we observed a DNP enhancement of 244 ± 84 resulting in a silicon polarization of 10.4 ± 3.4% following 2 h of microwave irradiation.

Analysis of protein oxidation in serum of fetal and newborn piglets and the influence of iron dextran on induction of protein carbonyls.

Science.gov (United States)

Methods were employed to evaluate serum biomarkers associated with protein oxidative stress and damage, to determine potential sources of metabolic stress in baby pigs. Protein carbonyls in serum were converted to dinitrophenyl (DNP) derivatives with DNP-hydrazine, precipitated with TCA, extracted i...

Recent results of studies of plasma fluctuations in stellarators by microwave scattering technique

International Nuclear Information System (INIS)

Skvortsova, N.N.; Batanov, G.M.; Kolik, L.V.; Petrov, A.E.; Pshenichnikov, A.A.; Sarksyan, K.A.; Kharchev, N.K.; Khol'nov, Yu.V.; Kubo, S.; Sanchez, J.

2005-01-01

-harmonic scattering. New results were obtained with the use of a small-angle scattering of the heating gyrotron radiation in LHD. In TJ-II, plasma density fluctuations were studied in experiments with the neutral beam injection. The experiments showed the presence of distinct quasi-harmonics in the first stage of the heating pulse. Simultaneously with these fluctuations, quasi-harmonics with the same frequencies were detected in the fluctuation signals of magnetic probes. Long time samples of density fluctuations (more than a million points at a sampling rate of 5 MHz) have for the first time measured. (author)

Compact type-I coil planet centrifuge for counter-current chromatography.

Science.gov (United States)

Yang, Yi; Gu, Dongyu; Liu, Yongqiang; Aisa, Haji Akber; Ito, Yoichiro

2010-02-19

A compact type-I coil planet centrifuge has been developed for performing counter-current chromatography. It has a revolution radius of 10 cm and a column holder height of 5 cm compared with 37 and 50 cm in the original prototype, respectively. The reduction in the revolution radius and column length permits application of higher revolution speed and more stable balancing of the rotor which leads us to learn more about its performance and the future potential of type-I coil planet centrifuge. The chromatographic performance of this apparatus was evaluated in terms of retention of the stationary phase (S(f)), peak resolution (R(s)), theoretical plate (N) and peak retention time (t(R)). The results of the experiment indicated that increasing the revolution speed slightly improved both the retention of the stationary phase and the peak resolution while the separation time is remarkably shortened to yield an excellent peak resolution at a revolution speed of 800 rpm. With a 12 ml capacity coiled column, DNP-DL-glu, DNP-beta-ala and DNP-l-ala were resolved at R(s) of 2.75 and 2.16 within 90 min at a flow rate of 0.4 ml/min. We believe that the compact type-I coil planet centrifuge has a high analytical potential. Published by Elsevier B.V.

Characterization of high-power RF structures using time-domain field codes

International Nuclear Information System (INIS)

Shang, C.C.; DeFord, J.F.; Swatloski, T.L.

1992-01-01

We have modeled gyrotron windows and gyrotron amplifier sever structures for TE modes in the 100--150 GHz range and have computed the reflection and transmission characteristics from the field data. Good agreement with frequency domain codes and analytic analysis have been obtained for some simple geometries. We present results for realistic structures with lousy coatings and describe implementation of microwave diagnostics

Electron energy recuperation in gyrodevices

International Nuclear Information System (INIS)

Savilov, A. V.; Nusinovich, G. S.; Sinitsyn, O. V.

2008-01-01

For many applications of gyrodevices, it is extremely important to increase their overall efficiency and reduce the power consumption. Therefore, at present, there are many gyrotrons operating with depressed collectors. These gyrotrons and their depressed collectors are typically designed with the use of available numerical codes. This paper is devoted to the analysis of the energy recuperation in gyrotrons, which is performed with the use of the Hamiltonian formalism. Such consideration gives some insight into the physics of gyrodevices and can be useful for estimating the benefits from utilizing depressed collectors. Both single-cavity gyromonotrons and multicavity gyrodevices in which the last cavity is excited by a prebunched beam are analyzed. Special attention is paid to a three-cavity, frequency-quadrupling gyrodevice.

High-power microwave transmission and mode conversion program. Progress report, June 15, 1993--June 15, 1994

International Nuclear Information System (INIS)

Vernon, R.J.; Lorbeck, J.A.

1994-06-01

This report briefly discusses the following topics: (1) Quasi-optical converter design for Varian gyrotron SN 4.1; (2) Quasi-optical converter cold-test measurement; (3) Modification of geometrical-optics synthesized surfaces; (4)Diffraction synthesis; (5) Tapered dimpled launcher; (6) Work on Vlasov converter system for Varian gyrotron SN 4.1R; (7) Analysis of gyrotron spurious modes; (8) MIT code benchmarking; (9) Development of low-power efficiency test for Vlasov converters; (10) Investigation of optimal beam waist size and mode content for injection into a circular and rectangular corrugated waveguides; (11) The effect of corrugations on reduction of the fields at the wall of waveguides; (12) Shipping of a microwave scanner to Varian and further microwave scanner development; and (13) Code transferred to Varian

High power plasma heating experiments on the Proto-MPEX facility

Science.gov (United States)

Bigelow, T. S.; Beers, C. J.; Biewer, T. M.; Caneses, J. F.; Caughman, J. B. O.; Diem, S. J.; Goulding, R. H.; Green, D. L.; Kafle, N.; Rapp, J.; Showers, M. A.

2017-10-01

Work is underway to maximize the power delivered to the plasma that is available from heating sources installed on the Prototype Materials Plasma Exposure eXperiment (Proto-MPEX) at ORNL. Proto-MPEX is a linear device that has a >100 kW, 13.56 MHz helicon plasma generator available and is intended for material sample exposure to plasmas. Additional plasma heating systems include a 10 kW 18 GHz electron cyclotron heating (ECH) system, a 25 kW 8 MHz ion cyclotron heating ICH system, and a 200 kW 28 GHz electron Bernstein wave (EBW) and ECH system. Most of the heating systems have relatively good power transmission efficiency, however, the 28 GHz EBW system has a lower efficiency owing to stringent requirements on the microwave launch characteristics for EBW coupling combined with the lower output mode purity of the early-model gyrotron in use and its compact mode converter system. A goal for the Proto-MPEX is to have a combined heating power of 200 kW injected into the plasma. Infrared emission diagnostics of the target plate combined with Thomson Scattering, Langmuir probe, and energy analyzer measurements near the target are utilized to characterize the plasmas and coupling efficiency of the heating systems. ORNL is managed by UT-Battelle, LLC, for the U.S. DOE under contract DE-AC-05-00OR22725.

Annual review of Plasma Physics Laboratory, Kyoto University, April, 1983

International Nuclear Information System (INIS)

1983-04-01

The devices for additionally heating joul-heated plasma in the Heliotron E, such as electron cyclotron resonance heating and neutral beam injection, were in operation in 1982. In the ECRH experiment, the microwaves of 200 kW at 28 GHz were generated by a gyrotron, but the pulse width was extended from 10 ms to 40 ms this year. By this, a currentless plasma of Te-1 keV was achieved. In the NB1 experiment, the neutral beam of about 1.5 MW was injected into joule-heated plasma, and the plasma of Ti(O)-950 eV, Te(O)-800 eV and Ne = 3 x 10 19 /m 3 was attained. The first experiment to inject neutral beam into ECRH currentless plasma was carried out. By this method, the density of the plasma increased as well as the ion temperature and electron temperature. As to the theory, a critical beta was calculated by using stellarator expansion, which should be 3 to 7 % in the Heliotron E. Two gyrotrons of 200 kW at 53 GHz each and an ion cyclotron resonance heating equipment of 1.5 MW at 26.7 MHz are prepared. As to the reactor study, the design of Heliotron H in the first phase was completed. The location of impurity sources in NB1 ion sources and beam lines was found. (Kako, I.)

Peptide conjugated polymeric nanoparticles as a carrier for targeted delivery of docetaxel.

Science.gov (United States)

Kulhari, Hitesh; Pooja, Deep; Shrivastava, Shweta; V G M, Naidu; Sistla, Ramakrishna

2014-05-01

The aim of this research work was to develop Bombesin peptide (BBN) conjugated, docetaxel loaded nanocarrier for the treatment of breast cancer. Docetaxel loaded nanoparticles (DNP) were prepared by solvent evaporation method using sodium cholate as surfactant. BBN was conjugated to DNP surface through covalent bonding. Both DNP and BBN conjugated DNP (BDNP) were characterized by various techniques such as dynamic light scattering, Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC) and thermogravimetric analysis. The particle diameter and zeta potential of BDNP were 136±3.95 nm and -10.8±2.7 mV, respectively. The change in surface charge and FTIR studies confirmed the formation of amide linkage between BBN and DNP. AFM analysis showed that nanoparticles were spherical in shapes. In nanoparticles, docetaxel was present in its amorphous form as confirmed by DSC and PXRD analysis and was stable during the thermal studies. The formulations showed the sustained release of DTX over the period of 120 h. During cellular toxicity assay in gastrin releasing peptide receptor positive breast cancer cells (MDA-MB-231), BDNP were found to be 12 times more toxic than pure DTX and Taxotere. The IC50 value for DTX, Taxotere, DNP and BDNP was >375, >375, 142.23 and 35.53 ng/ml, respectively. The above studies showed that Bombesin conjugated nanocarrier system could be a promising carrier for active targeting of anticancer drugs in GRP receptor over expressing cancer cells. Copyright © 2014 Elsevier B.V. All rights reserved.

MEASUREMENT OF AFFINITY IN SERUM SAMPLES OF ANTIGEN-FREE, GERM-FREE AND CONVENTIONAL MICE AFTER HYPERIMMUNIZATION WITH 2,4-DINITROPHENYL KEYHOLE LIMPET HEMOCYANIN, USING SURFACE-PLASMON RESONANCE

NARCIS (Netherlands)

BAKKER, R; LASONDER, E; BOS, NA

We previously investigated the primary and secondary responses and hyperimmunization to the T cell-dependent antigen 2,4-dinitrophenyl keyhole limpet hemocyanin (DNP-KLH) in antigen-free (AF), germ-free (GF) and conventional (CV) mice. Both the absolute and relative numbers of DNP-specific

Frozen Acrylamide Gels as Dynamic Nuclear Polarization Matrices.

KAUST Repository

Viger-Gravel, Jasmine; Berruyer, Pierrick; Gajan, David; Basset, Jean-Marie; Lesage, Anne; Tordo, Paul; Ouari, Olivier; Emsley, Lyndon

2017-01-01

We show that aqueous acrylamide gels can be used to provide dynamic nuclear polarization (DNP) NMR signal enhancements of around 200 at 9.4 T and 100 K. The enhancements are shown to increase with cross linker concentration and low concentrations of the AMUPol biradical. We show that this DNP matrix can be used in situations where conventional incipient wetness methods fail, such as to obtain DNP surface enhanced NMR spectra from inorganic nanoparticles. In particular, we obtain 113Cd spectra from CdTe-COOH NPs in minutes. The spectra clearly indicate a highly-disordered cadmium rich surface.

Frozen Acrylamide Gels as Dynamic Nuclear Polarization Matrices.

KAUST Repository

Viger-Gravel, Jasmine

2017-05-24

We show that aqueous acrylamide gels can be used to provide dynamic nuclear polarization (DNP) NMR signal enhancements of around 200 at 9.4 T and 100 K. The enhancements are shown to increase with cross linker concentration and low concentrations of the AMUPol biradical. We show that this DNP matrix can be used in situations where conventional incipient wetness methods fail, such as to obtain DNP surface enhanced NMR spectra from inorganic nanoparticles. In particular, we obtain 113Cd spectra from CdTe-COOH NPs in minutes. The spectra clearly indicate a highly-disordered cadmium rich surface.

Expression of reductases in continuous mammal cell cultures and its significance for the activation of nitroaromatics shown for the example of 1.6 dinitropyrene

International Nuclear Information System (INIS)

Reuter, U.

1993-01-01

The aim of the first part of the work was to establish the metabolism of 1,3- and 1,6-DNP in intact cells. This gave rise to the following questions. What metabolites are formed in cell lines with different enzyme outfits? What influence does the induction of P450 have on the metabolism of the two nitroaromates? Does the metabolism found in the different test cell lines permit any conclusions as to the activating mechanism of 1,6- and 1,3-DNP. In the second part these test cell lines were studied with respect to the expression of the reductases that might be involved in the metabolism of aromates. The following questions were of focal interest: Are cytochrome reductase, DT diaphorase and xanthine-oxidase expressed in the cell lines? If so, to what extent? Can these enzymes be induced in the test cell lines? In the last part the enzymes that reduce 1,6-DNP to gene-toxic products were identified. This required clarifying the following: What role do the above-mentioned reductases play in the activation of 1,6-DNP in individual cell lines? Are there other enzymes responsible for the activation of 1,6-DNP? (MG) [de

Evaluation of Baffle Fixes Film up Flow Sludge Blanket Filtration (BFUSBF System in Treatment of Wastewaters from Phenol and 2,4-Dinitrophenol Using Daphnia Magna Bioassay

Directory of Open Access Journals (Sweden)

Mohammad Javad Ghannadzadeh

2016-02-01

Full Text Available Background: Phenol and nitrophenol are common compounds found in different types of industrial wastewater known as serious threats to human health and natural environment. In this study, Daphnia magna was used to evaluate the effectiveness of "baffle fixes film up flow sludge blanket filtration" (BFUSBF system in elimination of phenolic compounds from water. Methods: D. magna cultures were used as toxicity index of phenol and 2,4-DNP mixtures after treatment by a pilot BFUSBF system which consisted of baffle in anoxic section and biofilm in aerobic sections. Initial concentrations were 312 mg/L phenol and 288 mg/L 2,4-dinitrophenol (2,4-DNP. Results: Bioassay tests showed that D. magna was influenced by the toxicity of phenol and 2,4 DNP mixtures. The comparison between the toxicity of initial phenol and 2,4-DNP mixtures and the output toxic unit (TU derived from BFUSBF treatment system showed that the TU of the effluent from BFUSBF reactor was much lower than that of the solution that entered the reactor. Conclusion: Based on the acute toxicity test, BFUSBF process could reduce phenol and 2,4-DNP in aqueous solutions. Therefore, it is possible to use BFUSBF process as an appropriate treatment option for wastewaters containing phenolic compounds.

Structural Analysis and Immuno-Stimulating Activity of an Acidic Polysaccharide from the Stems of Dendrobium nobile Lindl.

Science.gov (United States)

Wang, Jun-Hui; Zuo, Shu-Rong; Luo, Jian-Ping

2017-04-10

Dendrobium nobile Lindl., an epiphytic herb distributed in the Southeast Asia, is used as a tonic and antipyretic herbal medicine in China. In this study, a water-soluble acidic heteropolysaccharide, DNP-W4, containing mannose, glucose, galactose, xylose, rhamnose, and galacturonic acid, in the molar ratios of 1.0:4.9:2.5:0.5:1.0:0.9, was obtained from the stems of Dendrobium nobile Lindl. Using methylation analysis, partial acid hydrolysis, pectolyase treatment, NMR, and ESI-MS, the structure of DNP-W4 was elucidated. The obtained data indicated that DNP-W4 was a complex heteropolysaccharide and possessed a backbone composed of (1→4)-linked β-d-Glcp, (1→6)-linked β-d-Glcp, and (1→6)-linked β-d-Galp, with substitutes at O-4/6 of Glcp residues and O-3 of Galp. The branches of DNP-W4 were composed of terminal Manp, (1→6)-linked β-d-Manp, (1→3)-linked β-d-Glcp, β-d-Glcp, β-d-Galp, (1→4)-linked α-d-GalAp, (1→2)-linked α-L-Rhap, and Xylp. DNP-W4 had little immunological activities, but its derivatives had immuno-stimulating activities to some extent.

Determination of electromagnetic modes in oversized corrugated waveguides on the electron cyclotron resonance heating installation at the tokamak Tore Supra; Determination de modes electromagnetiques de guides d'ondes corrugues surdimensionnes sur l'installation de chauffage des electrons de tokamak Tore Supra

Energy Technology Data Exchange (ETDEWEB)

Courtois, L

2001-03-09

Electron cyclotron resonance heating (ECRH) in the Tore Supra tokamak constitutes an important step in the research aimed at obtaining thermonuclear fusion reactions. Electron heating is achieved by transmitting an electromagnetic wave from the oscillators (gyrotrons) to the plasma via the fundamental mode, propagating in oversized corrugated waveguides. Maximizing the proportion of the gyrotron power coupled to the fundamental waveguide mode is essential for the good functioning of the transmission line and for maximizing the effect on the plasma. This thesis gives all necessary tools for finding the proportion of the fundamental mode and all other modes present in passive components and at the output of the gyrotron as installed in the Tore Supra ECRH plant. This characterisation is based on obtaining amplitude and phase diagrams of the electric field on a plane transverse to the propagation axis. The most difficult part of obtaining these diagrams is measuring the phase which, despite the very short wavelength, is measured directly at low power levels. At high power levels the phase is numerically reconstructed from amplitude measurements for gyrotron characterisation. A complete theoretical study of the phase reconstruction code is given including its validation with theoretical diagrams. This study allows the realisation of a modal characterisation unit electromagnetic for measurement of radiated beams and usable in each part of the ECRH installation. At the end, the complete modal characterisation is given at low level for a mode converter and also at high level for the first series gyrotron installed at TORE SUPRA. (author)

Polarisation properties of irradiated ammonia (NH3 and ND3) at 1 K and 25 kG

International Nuclear Information System (INIS)

Riechert, H.

1982-11-01

Dynamic Nuclear Polarisation (DNP) of irradiated ammonia was examined in some detail at 1 K and 25 kG. In continuation of earlier studies conducted in Bonn, it was attempted to gain information about the prevailing mechanism of DNP in this material. Therefore the frequency dependence of DNP in NH 3 , of deuterons and unsubstituted protons in ND 3 , as well as the polarising time tau and the relaxation time T 1 in NH 3 were measured. Also the shape of the deuteron polarisation signal observed in ND 3 is discussed. The polarisation measurements in ND 3 rule out the equal spin temperature (EST) behaviour of proton and deuteron DNP that is observed in most of the currently used target materials. It is attempted to explain the observations with a differential solid state effect model. Results of calculations for NH 3 and ND 3 incorporating the measured EPR-spectra are presented. (orig.)

Large dose hyperpolarized water with dissolution-DNP at high magnetic field

DEFF Research Database (Denmark)

Lipsø, Hans Kasper Wigh; Bowen, Sean; Rybalko, Oleksandr

2016-01-01

was polarized and dissolved in a fluid path compatible with clinical polarizers. The volume of hyperpolarized water produced by this method enables angiography and perfusion measurements in large animals, as well as NMR experiments for studies of e.g. proton exchange and polarization transfer to other nuclei....

Recent results on electron cyclotron current drive and MHD activity in RTP

NARCIS (Netherlands)

Donne, A.J.H.; Schuller, F.C.; Oomens, A.A.M.; de Baar, M.R.; Barth, C.J.; Beurskens, M.N.A.; Box, F.M.A.; van Gelder, J.F.M.; Grobben, B.J.J.; Groot, de B.; Herranz, J.M.; Hogeweij, G.M.D.; Hokin, S.A.; Howard, J.; Hugenholtz, C.A.J.; Karelse, F.A.; de Kloe, J.; Kruijt, O.G.; Kuyvenhoven, S.; Lok, J.; Cardozo, N.J.L.; van der Meiden, H.J.; Meijer, F.G.; Montvai, A.; Oyevaar, T.; Pijper, F.J.; Polman, R.W.; Rommers, J.H.; Salzedas, F.; Schokker, B.C.; Smeets, P.H.M.; Tanzi, C.P.; Tito, C.J.; Verhaag, G.C.H.M.; Westerhof, E.

1997-01-01

The RTP tokamak (R = 0.72 m, a = 0.164 m, B-phi < 2 5.T, I-p = < 150 kA) is equipped with three gyrotrons (2 x 60 GHz, 180 kW, 100 ms each; 1 x 110 GHz, 500 kW, 200 ms) for electron cyclotron heating (ECH) and current drive (ECCD). The power from one of the 60 GHz gyrotrons is launched via an

Characterization of high-power RF structures using time-domain field codes

International Nuclear Information System (INIS)

Shang, C.C.; DeFord, J.F.; Swatloski, T.L.

1992-01-01

We have modeled gyrotron windows and gyrotron amplifier sever structures for TE modes in the 100-150 GHz range and have computed the reflection and transmission characteristics from the field data. Good agreement with frequency domain codes and analytic analysis have been obtained for some simple geometries. We present results for realistic structures with lossy coatings and describe implementation of microwave diagnostics. (Author) 5 figs., 7 refs

Trip electrical circuit of the gyrotion

International Nuclear Information System (INIS)

Rossi, J.O.

1987-09-01

The electron cyclotron resonance heating system of INPE/LAP is shown and the trip electrical circuit of the gyrotron is described, together with its fundamental aspects. The trip electrical circuit consists basically of a series regulator circuit which regulates the output voltage level and controls the pulse width time. Besides that, a protection circuit for both tubes, regulator and gyrotron, against faults in the system. (author) [pt

Microwave-gated dynamic nuclear polarization

DEFF Research Database (Denmark)

Bornet, Aurélien; Pinon, Arthur; Jhajharia, Aditya

2016-01-01

Dissolution dynamic nuclear polarization (D-DNP) has become a method of choice to enhance signals in nuclear magnetic resonance (NMR). Recently, we have proposed to combine cross-polarization (CP) with D-DNP to provide high polarization P((13)C) in short build-up times. In this paper, we show...

Risk of Damage to the Somatic Innervation of the Penis during the AdVanceProcedure: An Anatomical Study.

Science.gov (United States)

Hogewoning, Cornelis R C; Elzevier, Henk W; Pelger, Rob C M; Bekker, Milou D; DeRuiter, Marco C

2015-08-01

One of the methods to treat post radical prostatectomy stress urinary incontinence is the AdVance (American Medical Systems, Minnetonka, MN, USA) male sling procedure. During this procedure, the somatic innervation of the penis may be at risk for injury. Six AdVance procedures were performed in six donated bodies at the Anatomy and Embryology Department of the Leiden University Medical Centre. The pelves were dissected and the shortest distance between the sling and the dorsal nerve of the penis (DNP) was documented. The aim of this study was to describe the anatomical relation between the AdVance male sling and penile nerves based on the dissection of six adult male pelves. The AdVance male sling procedure was conducted in six donated male bodies. After placement, the pelves were dissected and the shortest distance between sling and the DNP was documented. The main outcome measure was the distance between the AdVance male sling and the DNP. The mean distance of the sling to the DNP was 4.1 mm and was found situated directly next to the nerve (distance 0 mm) in 4 out of 12 (33%) hemipelves. The distance of the sling to the obturator neurovascular bundle was 30 mm or more in all six bodies. Damage to the DNP caused by the AdVance male sling procedure appears to be an extremely rare complication, which has not been described in current literature. The proximity of the AdVance to the DNP could, however, pose a risk that should be taken into consideration by physicians and patients when opting for surgery. © 2015 International Society for Sexual Medicine.

ICRF experiments and potential formation on the GAMMA 10 tandem mirror

International Nuclear Information System (INIS)

Ichimura, M.; Cho, T.; Higaki, H.

2005-01-01

Target plasmas, on which the formation of the electrostatic potentials and the improvement of the confinement are studied, are produced with ICRF in the GAMMA 10 tandem mirror. The ion temperature of more than 10 keV has been achieved in relatively low density plasmas. When the strong ICRF heating is applied, it is observed that the high frequency and the low frequency fluctuations are excited and suppress the increase in the plasma parameters. Recently, a new high power gyrotron system has been constructed and the plug ECRH power extends up to 370 kW. The improvement of the confinement due to the formation of the potential in the axial direction and the strong radial electric field shear has been observed. (author)

The immunological properties of haptens coupled to thymus-independent carrier molecules. IV. The IgG response to dinitrophenylated Ficoll.

Science.gov (United States)

Klaus, G G; Phillips, J M; Humphrey, J H; Dresser, D W; Cross, A M

1976-06-01

Dinitrophenylated polysucrose (DNP-Ficoll) elicits T cell-independent IgM anti-DNP antibody formation in mice. This antigen also elicits a heterogeneous IgG1 and IgG2 anti-DNP response, which is operationally as T-independent as the IgM response. However, a concomitant graft-versus-host reaction markedly enhances the IgG response (allogeneic effect). These results confirm those of others, indicating that a certain proportion of the precursors of IgG-producing cells can be triggered by some T-independent antigens. However, our results suggest that even with such antigens optimal triggering of IgG precursors requires T cell help.

Verdazyl-ribose: A new radical for solid-state dynamic nuclear polarization at high magnetic field

Science.gov (United States)

Thurber, Kent R.; Le, Thanh-Ngoc; Changcoco, Victor; Brook, David J. R.

2018-04-01

Solid-state dynamic nuclear polarization (DNP) using the cross-effect relies on radical pairs whose electron spin resonance (ESR) frequencies differ by the nuclear magnetic resonance (NMR) frequency. We measure the DNP provided by a new water-soluble verdazyl radical, verdazyl-ribose, under both magic-angle spinning (MAS) and static sample conditions at 9.4 T, and compare it to a nitroxide radical, 4-hydroxy-TEMPO. We find that verdazyl-ribose is an effective radical for cross-effect DNP, with the best relative results for a non-spinning sample. Under non-spinning conditions, verdazyl-ribose provides roughly 2× larger 13C cross-polarized (CP) NMR signal than the nitroxide, with similar polarization buildup times, at both 29 K and 76 K. With MAS at 7 kHz and 1.5 W microwave power, the verdazyl-ribose does not provide as much DNP as the nitroxide, with the verdazyl providing less NMR signal and a longer polarization buildup time. When the microwave power is decreased to 30 mW with 5 kHz MAS, the two types of radical are comparable, with the verdazyl-doped sample having a larger NMR signal which compensates for its longer polarization buildup time. We also present electron spin relaxation measurements at Q-band (1.2 T) and ESR lineshapes at 1.2 and 9.4 T. Most notably, the verdazyl radical has a longer T1e than the nitroxide (9.9 ms and 1.3 ms, respectively, at 50 K and 1.2 T). The verdazyl electron spin lineshape is significantly affected by the hyperfine coupling to four 14N nuclei, even at 9.4 T. We also describe 3000-spin calculations to illustrate the DNP potential of possible radical pairs: verdazyl-verdazyl, verdazyl-nitroxide, or nitroxide-nitroxide pairs. These calculations suggest that the verdazyl radical at 9.4 T has a narrower linewidth than optimal for cross-effect DNP using verdazyl-verdazyl pairs. Because of the hyperfine coupling contribution to the electron spin linewidth, this implies that DNP using the verdazyl radical would improve at lower

Verdazyl-ribose: A new radical for solid-state dynamic nuclear polarization at high magnetic field.

Science.gov (United States)

Thurber, Kent R; Le, Thanh-Ngoc; Changcoco, Victor; Brook, David J R

2018-04-01

Solid-state dynamic nuclear polarization (DNP) using the cross-effect relies on radical pairs whose electron spin resonance (ESR) frequencies differ by the nuclear magnetic resonance (NMR) frequency. We measure the DNP provided by a new water-soluble verdazyl radical, verdazyl-ribose, under both magic-angle spinning (MAS) and static sample conditions at 9.4 T, and compare it to a nitroxide radical, 4-hydroxy-TEMPO. We find that verdazyl-ribose is an effective radical for cross-effect DNP, with the best relative results for a non-spinning sample. Under non-spinning conditions, verdazyl-ribose provides roughly 2× larger 13 C cross-polarized (CP) NMR signal than the nitroxide, with similar polarization buildup times, at both 29 K and 76 K. With MAS at 7 kHz and 1.5 W microwave power, the verdazyl-ribose does not provide as much DNP as the nitroxide, with the verdazyl providing less NMR signal and a longer polarization buildup time. When the microwave power is decreased to 30 mW with 5 kHz MAS, the two types of radical are comparable, with the verdazyl-doped sample having a larger NMR signal which compensates for its longer polarization buildup time. We also present electron spin relaxation measurements at Q-band (1.2 T) and ESR lineshapes at 1.2 and 9.4 T. Most notably, the verdazyl radical has a longer T 1e than the nitroxide (9.9 ms and 1.3 ms, respectively, at 50 K and 1.2 T). The verdazyl electron spin lineshape is significantly affected by the hyperfine coupling to four 14 N nuclei, even at 9.4 T. We also describe 3000-spin calculations to illustrate the DNP potential of possible radical pairs: verdazyl-verdazyl, verdazyl-nitroxide, or nitroxide-nitroxide pairs. These calculations suggest that the verdazyl radical at 9.4 T has a narrower linewidth than optimal for cross-effect DNP using verdazyl-verdazyl pairs. Because of the hyperfine coupling contribution to the electron spin linewidth, this implies that DNP using the verdazyl

A fast switch, combiner and narrow-band filter for high-power millimetre wave beams

Science.gov (United States)

Kasparek, W.; Petelin, M. I.; Shchegolkov, D. Yu; Erckmann, V.; Plaum, B.; Bruschi, A.; ECRH Groups at IPP Greifswald; Karlsruhe, FZK; Stuttgart, IPF

2008-05-01

A fast directional switch (FADIS) is described, which allows controlled switching of high-power microwaves between two outputs. A possible application could be synchronous stabilization of neoclassical tearing modes (NTMs). Generally, the device can be used to share the installed EC power between different types of launchers or different applications (e.g. in ITER, midplane/upper launcher). The switching is performed electronically without moving parts by a small frequency-shift keying of the gyrotron (some tens of megahertz), and a narrow-band diplexer. The device can be operated as a beam combiner also, which offers attractive transmission perspectives in multi-megawatt ECRH systems. In addition, these diplexers are useful for plasma diagnostic systems employing high-power sources due to their filter characteristics. The principle and the design of a four-port quasi-optical resonator diplexer is presented. Low-power measurements of switching contrast, mode purity and efficiency show good agreement with theory. Preliminary frequency modulation characteristics of gyrotrons are shown, and first results from high-power switching experiments using the ECRH system for W7-X are presented.

A fast switch, combiner and narrow-band filter for high-power millimetre wave beams

International Nuclear Information System (INIS)

Kasparek, W.; Plaum, B.; Petelin, M.I.; Shchegolkov, D.Yu; Erckmann, V.; Bruschi, A.

2008-01-01

A fast directional switch (FADIS) is described, which allows controlled switching of high-power microwaves between two outputs. A possible application could be synchronous stabilization of neoclassical tearing modes (NTMs). Generally, the device can be used to share the installed EC power between different types of launchers or different applications (e.g. in ITER, midplane/upper launcher). The switching is performed electronically without moving parts by a small frequency-shift keying of the gyrotron (some tens of megahertz), and a narrow-band diplexer. The device can be operated as a beam combiner also, which offers attractive transmission perspectives in multi-megawatt ECRH systems. In addition, these diplexers are useful for plasma diagnostic systems employing high-power sources due to their filter characteristics. The principle and the design of a four-port quasi-optical resonator diplexer is presented. Low-power measurements of switching contrast, mode purity and efficiency show good agreement with theory. Preliminary frequency modulation characteristics of gyrotrons are shown, and first results from high-power switching experiments using the ECRH system for W7-X are presented

Free Radical Imaging Using In Vivo Dynamic Nuclear Polarization-MRI.

Science.gov (United States)

Utsumi, Hideo; Hyodo, Fuminori

2015-01-01

Redox reactions that generate free radical intermediates are essential to metabolic processes, and their intermediates can produce reactive oxygen species, which may promote diseases related to oxidative stress. The development of an in vivo electron spin resonance (ESR) spectrometer and its imaging enables us noninvasive and direct measurement of in vivo free radical reactions in living organisms. The dynamic nuclear polarization magnetic resonance imaging (DNP-MRI), also called PEDRI or OMRI, is also a new imaging method for observing free radical species in vivo. The spatiotemporal resolution of free radical imaging with DNP-MRI is comparable with that in MRI, and each of the radical species can be distinguished in the spectroscopic images by changing the frequency or magnetic field of ESR irradiation. Several kinds of stable nitroxyl radicals were used as spin probes to detect in vivo redox reactions. The signal decay of nitroxyl probes, which is determined with in vivo DNP-MRI, reflects the redox status under oxidative stress, and the signal decay is suppressed by prior administration of antioxidants. In addition, DNP-MRI can also visualize various intermediate free radicals from the intrinsic redox molecules. This noninvasive method, in vivo DNP-MRI, could become a useful tool for investigating the mechanism of oxidative injuries in animal disease models and the in vivo effects of antioxidant drugs. © 2015 Elsevier Inc. All rights reserved.

Bioproducts for Sludge Reduction in Activated Sludge Systems Treating Oil Refinery Wastewater

Directory of Open Access Journals (Sweden)

Alexandre V.M.F.

2016-03-01

Full Text Available The use of bioproducts that change the cellular metabolism and reduce microbial growth without affecting the organic matter removal is very promising for reducing the amount of sludge in wastewater treatment systems. In this study, two bioproducts were evaluated and compared with a well-known chemical (2,4-DiNitroPhenol – DNP in activated sludge treating petroleum refinery wastewater. In batch experiments, 10 mg/L of DNP, 0.8 mg/L of a bioproduct based on Folic Acid (FA and 10 mg/L of a bioproduct based on Stress Proteins (SP led to 30.6%, 43.2% and 29.8% lower disposal of total solids, respectively. Operating on a continuous regimen, the addition of 10 mg/L of the bioproduct based on SP led to 45.7% lower disposal for 50 days. In all cases, no loss of efficiency in the Chemical Oxygen Demand (COD removal was observed.

Development of an institutional review board preapproval process for Doctor of Nursing Practice students: process and outcome.

Science.gov (United States)

Szanton, Sarah L; Taylor, Holly A; Terhaar, Mary

2013-01-01

As Doctor of Nursing Practice (DNP) programs proliferate, effective collaboration with institutional review boards (IRBs) is important to protect human subjects. It is particularly important that faculty and students recognize which DNP students' projects should be considered as "human subjects research" or "quality improvement." The former require IRB review, whereas the latter may be eligible for expedited review or may be considered exempt. We report outcomes following implementation of a combination of didactic training, one-to-one consultation, and a decision support protocol to improve preparation for and collaboration with the IRB at a large university. In the first year of using this protocol, 53% of projects were deemed human subjects research and received IRB review. The other 47% were deemed quality improvement projects and did not require IRB review. We offer our experience as an approach for teaching students how to protect the subjects included in their quality improvement activities. Copyright 2012, SLACK Incorporated.

Sub-minute kinetics of human red cell fumarase: 1 H spin-echo NMR spectroscopy and 13 C rapid-dissolution dynamic nuclear polarization.

Science.gov (United States)

Shishmarev, Dmitry; Wright, Alan J; Rodrigues, Tiago B; Pileio, Giuseppe; Stevanato, Gabriele; Brindle, Kevin M; Kuchel, Philip W

2018-03-01

Fumarate is an important probe of metabolism in hyperpolarized magnetic resonance imaging and spectroscopy. It is used to detect the release of fumarase in cancer tissues, which is associated with necrosis and drug treatment. Nevertheless, there are limited reports describing the detailed kinetic studies of this enzyme in various cells and tissues. Thus, we aimed to evaluate the sub-minute kinetics of human red blood cell fumarase using nuclear magnetic resonance (NMR) spectroscopy, and to provide a quantitative description of the enzyme that is relevant to the use of fumarate as a probe of cell rupture. The fumarase reaction was studied using time courses of 1 H spin-echo and 13 C-NMR spectra. 1 H-NMR experiments showed that the fumarase reaction in hemolysates is sufficiently rapid to make its kinetics amenable to study in a period of approximately 3 min, a timescale characteristic of hyperpolarized 13 C-NMR spectroscopy. The rapid-dissolution dynamic nuclear polarization (RD-DNP) technique was used to hyperpolarize [1,4- 13 C]fumarate, which was injected into concentrated hemolysates. The kinetic data were analyzed using recently developed FmR α analysis and modeling of the enzymatic reaction using Michaelis-Menten equations. In RD-DNP experiments, the decline in the 13 C-NMR signal from fumarate, and the concurrent rise and fall of that from malate, were captured with high spectral resolution and signal-to-noise ratio, which allowed the robust quantification of fumarase kinetics. The kinetic parameters obtained indicate the potential contribution of hemolysis to the overall rate of the fumarase reaction when 13 C-NMR RD-DNP is used to detect necrosis in animal models of implanted tumors. The analytical procedures developed will be applicable to studies of other rapid enzymatic reactions using conventional and hyperpolarized substrate NMR spectroscopy. Copyright © 2018 John Wiley & Sons, Ltd.

HUMORAL IMMUNE-RESPONSE TO 2,4-DINITROPHENYL KEYHOLE LIMPET HEMOCYANIN IN ANTIGEN-FREE, GERM-FREE AND CONVENTIONAL BALB/C MICE

NARCIS (Netherlands)

BOS, NA; PLOPLIS, VA

The B cell immune response to 2,4-dinitrophenyl (DNP) keyhole limpet hemocyanin was compared in antigen-free, germ-free and conventional BALB/c mice. The numbers of total and of DNP-specific IgM-, IgG- and IgA-secreting cells in the spleen were determined by enzyme-linked immunosorbent plaque assays

Experience of Soviet Medicine in a Great Patriotic War 1941-1945. Part 2 (Opyt Sovetskoy Meditsimy v Velikoy Otechestvennoy Voyne 1941-1945),

Science.gov (United States)

1981-04-15

splints. First of all gave grounds to suspect break anamnesis and complaints of casualty. Anamsesis was always short: felt the strong blow into the hand...stage consisted of the rendering to the necessary aid and the rapid evacuation of casualty on DNP. Diagnosis was placed on the basis of anamnesis and... anamnesis , assembled in further stages, this gap/spacing was completed with the indication of Iccal anesthetization. The primary surgical prccessing of

Elmo Bumpy Torus proof of principle, Phase II: Title 1 report. Volume IV. Microwave system. Preliminary design report

International Nuclear Information System (INIS)

Adams, R.N.

1982-01-01

The EBT-P Microwave System provides microwaves for electron cyclotron resonance heating (ECRH) to both stabilize and heat the EBT-P plasma. A 28 gigahertz (GHz) system is required to form the hot electron annulus plasma that provides MHD stabilization to the core plasma. A 60 GHz system is required to heat the core plasma and will provide some second harmonic heating of the hot electron annulus. The principal microwave system elements and their design characteristics are summarized. The microwave system includes 200 kilowatt (kW) gyrotrons at 60 GHz for core heating and 200 kW gyrotrons at 28 GHz for annulus heating. The basic operating complement will be six (6) 60 GHz tubes and two (2) 28 GHz tubes. PACE (Plant and Capital Equipment) procurement will include four (4) 60 GHz gyrotrons with two (2) GHz tubes procured under operations and the two (2) 28 GHz tubes will be provided, with mounts, from the EBT-S program. Each tube is rigidly mounted on an oil filled tank assembly which provides electrical isolation and cooling. All tubes and mounts will be located in the lower level of the torus enclosure. An extensive demineralized water flow system is required to provide gyrotron cooling

Remote Control System of the TJ-II Microwave Transmission Lines Mirrors

International Nuclear Information System (INIS)

Lopez Sanchez, A.; Fernandez, A.; Cappa, A.; Gama, J. de la; Olivares, J.; Garcia, R.; Chamorro, M.

2007-01-01

The ECRH system of the TJ-II stellarator has two gyrotrons, which deliver a maximum power of 300 kW each at a frequency of 53.2 GHz. Another 28 GHz gyrotron will be used to heat the plasma by electron Bernstein waves (EBWH). The microwave power is transmitted from the gyrotrons to the vacuum chamber by two quasi-optical transmission lines for ECRH and a corrugated waveguide for EBWH. All transmission lines have an internal movable mirror inside the vacuum chamber to focus the beam and to be able to change the launching angle. The control of the beam polarization is very important and the lines have two corrugated mirrors, which actuate as polarizers. In this report the control system of the position of these three internal mirrors and the polarizers of the EBWH transmission line is described. (Author) 20 refs

Progress of the 10 MW ECRH System for W7-X

International Nuclear Information System (INIS)

Michel, G.; Brand, P.; Dammertz, G.

2003-01-01

The electron cyclotron resonance heating system for the W7-X stellarator is a joint effort of the Max-Planck-Institut fuer Plasmaphysik in Greifswald, the Institut fuer Plasmaforschung Stuttgart and the Forschungszentrum Karlsruhe under the supervision of the latter. Currently it is being constructed at the Greifswald branch of IPP. It will consist of 10 gyrotrons (each with 1 MW 140 GHz in the CW regime) and a quasi optical multi-beam transmission line. W7-X gyrotron candidates are being developed separately in Western Europe and the USA. The prototype phase of the gyrotrons is almost over and significant results have been achieved. The manufacturing of the transmission line is ongoing. An overview over the system including data acquisition and control issues will be given and the current status of the construction will be presented. (authors)

High-power microwave transmission systems for electron cyclotron resonance plasma heating

International Nuclear Information System (INIS)

Vernon, R.J.

1990-08-01

This progress report is for the fifth year of a grant from the US Department of Energy (Contract FG02-85ER52122) for the design, development, and fabrication of ECRF transmission and mode conversion systems to transport microwave power from a gyrotron, or other high power source, to a magnetically confined plasma. (This period is also the second year covered by a three-year renewal proposal submitted in June of 1988.) The development of new and improved components for such systems and underlying theory, where necessary, is the focus of this project. Devising and improving component testing and diagnostic techniques is also an important part of this effort. The development of possible designs for sections of gyrotrons themselves, such as tapers or Vlasov-type launchers, in support of the Varian gyrotron development program is also considered in this work

Remote Control System of the TJ-II Microwave Transmission Lines Mirrors; Sistema de Control Remoto de los Espejos de las Lineas de Transmision de Microondas del TJ-II

Energy Technology Data Exchange (ETDEWEB)

Lopez Sanchez, A.; Fernandez, A.; Cappa, A.; Gama, J. de la; Olivares, J.; Garcia, R.; Chamorro, M.

2007-09-27

The ECRH system of the TJ-II stellarator has two gyrotrons, which deliver a maximum power of 300 kW each at a frequency of 53.2 GHz. Another 28 GHz gyrotron will be used to heat the plasma by electron Bernstein waves (EBWH). The microwave power is transmitted from the gyrotrons to the vacuum chamber by two quasi-optical transmission lines for ECRH and a corrugated waveguide for EBWH. All transmission lines have an internal movable mirror inside the vacuum chamber to focus the beam and to be able to change the launching angle. The control of the beam polarization is very important and the lines have two corrugated mirrors, which actuate as polarizers. In this report the control system of the position of these three internal mirrors and the polarizers of the EBWH transmission line is described. (Author) 20 refs.

Just Care: Learning from and with Graduate Students in a Doctor of Nursing Practice Program

Science.gov (United States)

Boquet, Elizabeth; Kazer, Meredith; Manister, Nancy; Lucas, Owen; Shaw, Michael; Madaffari, Valerie; Gannett, Cinthia

2015-01-01

In 2010, Fairfield University, a Jesuit Carnegie Masters Level 1 University located in the Northeast, established its first doctoral-level program: the Doctorate of Nursing Practice (DNP). In a developing program such as the DNP, some of the most pressing concerns of current rhetoric and writing in the disciplines align and interact with the…

NMR of insensitive nuclei enhanced by dynamic nuclear polarization.

Science.gov (United States)

Miéville, Pascal; Jannin, Sami; Helm, Lothar; Bodenhausen, Geoffrey

2011-01-01

Despite the powerful spectroscopic information it provides, Nuclear Magnetic Resonance (NMR) spectroscopy suffers from a lack of sensitivity, especially when dealing with nuclei other than protons. Even though NMR can be applied in a straightforward manner when dealing with abundant protons of organic molecules, it is very challenging to address biomolecules in low concentration and/or many other nuclei of the periodic table that do not provide as intense signals as protons. Dynamic Nuclear Polarization (DNP) is an important technique that provides a way to dramatically increase signal intensities in NMR. It consists in transferring the very high electron spin polarization of paramagnetic centers (usually at low temperature) to the surrounding nuclear spins with appropriate microwave irradiation. DNP can lead to an enhancement of the nuclear spin polarization by up to four orders of magnitude. We present in this article some basic concepts of DNP, describe the DNP apparatus at EPFL, and illustrate the interest of the technique for chemical applications by reporting recent measurements of the kinetics of complexation of 89Y by the DOTAM ligand.

Electron paramagnetic resonance and dynamic nuclear polarization of char suspensions: surface science and oximetry

International Nuclear Information System (INIS)

Clarkson, R.B.; Odintsov, B.M.; Ceroke, P.J.; Ardenkjaer-Larsen, J.H.; Fruianu, M.; Belford, R.L.

1998-01-01

Carbon chars have been synthesized in our laboratory from a variety of starting materials, by means of a highly controlled pyrolysis technique. These chars exhibit electron paramagnetic resonance (EPR) line shapes which change with the local oxygen concentration in a reproducible and stable fashion; they can be calibrated and used for oximetry. Biological stability and low toxicity make chars good sensors for in vivo measurements. Scalar and dipolar interactions of water protons at the surfaces of chars may be utilized to produce dynamic nuclear polarization (DNP) of the 1 H nuclear spin population in conjunction with electron Zeeman pumping. Low-frequency EPR, DNP and DNP-enhanced MRI all show promise as oximetry methods when used with carbon chars. (author)

Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.

Science.gov (United States)

Cerqueira, Fernanda M; Laurindo, Francisco R M; Kowaltowski, Alicia J

2011-03-31

Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR). Since treatment of mice with dinitrophenol (DNP) promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it could also impact biogenesis. We found that DNP and CR increase citrate synthase activity, PGC-1α, cytochrome c oxidase and mitofusin-2 expression, as well as fasting plasma levels of NO• products. In addition, eNOS and Akt phosphorylation in skeletal muscle and visceral adipose tissue was activated in fasting CR and DNP animals. Overall, our results indicate that systemic mild uncoupling activates eNOS and Akt-dependent pathways leading to mitochondrial biogenesis.

Profile control simulations and experiments on TCV: a controller test environment and results using a model-based predictive controller

Science.gov (United States)

Maljaars, E.; Felici, F.; Blanken, T. C.; Galperti, C.; Sauter, O.; de Baar, M. R.; Carpanese, F.; Goodman, T. P.; Kim, D.; Kim, S. H.; Kong, M.; Mavkov, B.; Merle, A.; Moret, J. M.; Nouailletas, R.; Scheffer, M.; Teplukhina, A. A.; Vu, N. M. T.; The EUROfusion MST1-team; The TCV-team

2017-12-01

The successful performance of a model predictive profile controller is demonstrated in simulations and experiments on the TCV tokamak, employing a profile controller test environment. Stable high-performance tokamak operation in hybrid and advanced plasma scenarios requires control over the safety factor profile (q-profile) and kinetic plasma parameters such as the plasma beta. This demands to establish reliable profile control routines in presently operational tokamaks. We present a model predictive profile controller that controls the q-profile and plasma beta using power requests to two clusters of gyrotrons and the plasma current request. The performance of the controller is analyzed in both simulation and TCV L-mode discharges where successful tracking of the estimated inverse q-profile as well as plasma beta is demonstrated under uncertain plasma conditions and the presence of disturbances. The controller exploits the knowledge of the time-varying actuator limits in the actuator input calculation itself such that fast transitions between targets are achieved without overshoot. A software environment is employed to prepare and test this and three other profile controllers in parallel in simulations and experiments on TCV. This set of tools includes the rapid plasma transport simulator RAPTOR and various algorithms to reconstruct the plasma equilibrium and plasma profiles by merging the available measurements with model-based predictions. In this work the estimated q-profile is merely based on RAPTOR model predictions due to the absence of internal current density measurements in TCV. These results encourage to further exploit model predictive profile control in experiments on TCV and other (future) tokamaks.

Inhibition of oxidative phosphorylation for enhancing citric acid production by Aspergillus niger.

Science.gov (United States)

Wang, Lu; Zhang, Jianhua; Cao, Zhanglei; Wang, Yajun; Gao, Qiang; Zhang, Jian; Wang, Depei

2015-01-16

The spore germination rate and growth characteristics were compared between the citric acid high-yield strain Aspergillus niger CGMCC 5751 and A. niger ATCC 1015 in media containing antimycin A or DNP. We inferred that differences in citric acid yield might be due to differences in energy metabolism between these strains. To explore the impact of energy metabolism on citric acid production, the changes in intracellular ATP, NADH and NADH/NAD+ were measured at various fermentation stages. In addition, the effects of antimycin A or DNP on energy metabolism and citric acid production was investigated by CGMCC 5751. By comparing the spore germination rate and the extent of growth on PDA plates containing antimycin A or DNP, CGMCC 5751 was shown to be more sensitive to antimycin A than ATCC 1015. The substrate-level phosphorylation of CGMCC 5751 was greater than that of ATCC 1015 on PDA plates with DNP. DNP at tested concentrations had no apparent effect on the growth of CGMCC 5751. There were no apparent effects on the mycelial morphology, the growth of mycelial pellets or the dry cell mass when 0.2 mg L(-1) antimycin A or 0.1 mg L(-1) DNP was added to medium at the 24-h time point. The concentrations of intracellular ATP, NADH and NADH/NAD+ of CGMCC 5751 were notably lower than those of ATCC 1015 at several fermentation stages. Moreover, at 96 h of fermentation, the citric acid production of CGMCC 5751 reached up to 151.67 g L(-1) and 135.78 g L(-1) by adding 0.2 mg L(-1) antimycin A or 0.1 mg L(-1) DNP, respectively, at the 24-h time point of fermentation. Thus, the citric acid production of CGMCC 5751 was increased by 19.89% and 7.32%, respectively. The concentrations of intracellular ATP, NADH and NADH/NAD+ of the citric acid high-yield strain CGMCC 5751 were notably lower than those of ATCC 1015. The excessive ATP has a strong inhibitory effect on citric acid accumulation by A. niger. Increasing NADH oxidation and appropriately reducing the concentration of

EU Developments of the ITER ECRH System

International Nuclear Information System (INIS)

Henderson, M.

2006-01-01

The electron cyclotron (EC) heating and current drive (H (and) CD) system of ITER will deliver 20 MW/CW in the plasma at 170 GHz for H (and) CD in addition to 2.5 MW/3 s at 120 GHz for plasma start-up. The EC system is composed of power supplies (PS), up to 24 H (and) CD gyrotrons (1 to 2 MW tubes), 3 start-up gyrotrons (1 MW tubes), 24 transmission lines and two sets of launching antennas: equatorial (EL) and upper (UL) launchers. Under the present ITER procurement package the EU is responsible for one third of the H (and) CD 170 GHz gyrotrons, all PSs associated with the H (and) CD system, and the whole set (4) of upper launchers. In all areas of participation, the EU EC partnership (coordinated by the European Fusion Development Association - EFDA) aims toward advancing the technology of each of these subsystems. For example, procurement of Pulse Step Modulator (PSM) HVPS is under consideration, which might have equivalent costs to the present ITER design (thyristor HVPS and HV series switch), but with an increased flexibility in operation and variation in the EC power waveform. The EU is at the forefront in gyrotron research and is developing a 2 MW CW 170 GHz coaxial cavity gyrotron offering an increase in output power while maintaining moderate power densities in the gyrotron cavity and collector. THALES R in collaboration with its EFDA partners (FZK, CRPP, TEKES) is manufacturing a series of prototype tubes in three phases of typically 1 s, 100 s and then CW pulse capacity (∼ 20 10 ). A 2 MW, CW gyrotron test facility is being built at CRPP that will be used to develop the 2 MW coaxial tube, in addition to testing various components required by the EC system. EFDA has undertaken a parallel development of two launcher options: front (FS) and remote (RS) steering, with the aim of providing an optimum launcher for ITER weighing EC physics aspects and operation reliability. The FS launcher (ITER reference design) offers a significant enhancement in physics

Rational Design of Therapeutic and Diagnostic Against Botulinum Neurotoxin

Science.gov (United States)

2006-12-01

induced fluorescence Da, kDa Dalton, Kilodalton DMPS 2, 3-dimercaptopropanesulfonate DMSO Dimethylsulfoxide Dnp 2, 4-dinitrophenol DRDC Defence...high performance liquid chromatography electrospray ionization mass spectrometry (HPLC-ESI-MS) experiment. H1R3 was dissolved in 10% DMSO / 0.1...separation of peptides. A linear solvent gradient was used in the HPLC separation at an initial condition of 5% acetonitrile in 0.1% TFA/water, up to

Thermal performance enhancement in nanofluids containing diamond nanoparticles

International Nuclear Information System (INIS)

Xie Huaqing; Yu Wei; Li Yang

2009-01-01

Nanofluids, nanoparticle suspensions prepared by dispersing nanoscale particles in a base fluid, have been gaining interest lately due to their potential to greatly outperform traditional thermal transport liquids. Diamond has the highest thermal transport capacity in nature and diamond particles are often used as filler in mixtures for upgrading the performance of a matrix. It is reasonable to expect that the addition of diamond nanoparticles (DNPs) would lead to thermal performance enhancement in a base fluid. In this study, homogeneous and stable nanofluids composed of DNPs as the inclusions and a mixture of ethylene glycol (EG) and water as base fluid have been prepared. Acid mixtures of perchloric acid, nitric acid and hydrochloric acid were employed to purify and tailor the DNPs to eliminate impurities and to enhance their dispersibilty. Ultrasound and the alkalinity of solution are beneficial to the deaggregation of the soft DNP aggregations. The thermal conductivity enhancement of the DNP nanofluids increases with DNP loading and the thermal conductivity enhancement is more than 18.0% for a nanofluid at a DNP volume fraction of 0.02. Viscosity measurements show that the DNP nanofluids demonstrate Newtonian behaviour, and the viscosity significantly decreases with temperature. With increasing volume fraction of DNPs, the convective heat transfer coefficient increases first, and then decreases with a further increase in the volume fraction of DNPs. The nanofluid with a volume fraction of 0.005 has optimal overall thermal performance.

Therapeutic potential of Mucuna pruriens (Linn.) on ageing induced damage in dorsal nerve of the penis and its implication on erectile function: an experimental study using albino rats.

Science.gov (United States)

Seppan, Prakash; Muhammed, Ibrahim; Mohanraj, Karthik Ganesh; Lakshmanan, Ganesh; Premavathy, Dinesh; Muthu, Sakthi Jothi; Wungmarong Shimray, Khayinmi; Sathyanathan, Sathya Bharathy

2018-02-15

To study the effect of ethanolic seed extract of Mucuna pruriens on damaged dorsal nerve of the penis (DNP) in aged rat in relation to penile erection. The rats were divided into four groups Young (3 months), Aged (24 - 28 months), Aged + M. pruriens, and Young + M. pruriens (200 mg/kg b.w/60 days) and were subjected to the hypophysial - gonadal axis, nerve conduction velocity (NCV), and penile reflex. DNP sections were stained with nitric oxide synthase (nNOS), nicotinamide adenine dinucleotide phosphate (NaDPH) diaphorase, androgen receptor (AR), and osmium tetroxide. Terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) staining, electron microscopy(EM) and histometric analyses were done. Significant disturbance in hypophysial - gonadal axis was noted in aged rat. With reduced number of myelinated fibers, diameter, vacuolization, indentation of the myelin sheath, and degeneration. nNOS and its cofactor (NaDPH diaphorase) were reduced in aged rat DNP. NCV was slow in aged rats and concomitant poor penile reflex was also noted. AR showed reduced expression in aged rat DNP when compared to young and control groups. TUNEL positive cells were increased in aged rat DNP. These pathological changes were remarkably reduced or recovered in M. pruriens treated aged rats. The results indicate a multi-factorial therapeutic activity in penile innervations towards sustaining the penile erection in the presence of the extract in aged rats and justifying the claim of traditional usage.

Recent Progress on ECH Technology for ITER

Science.gov (United States)

Sirigiri, Jagadishwar

2005-10-01

The Electron Cyclotron Heating and Current Drive (ECH&CD) system for ITER is a critical ITER system that must be available for use on Day 1 of the ITER experimental program. The applications of the system include plasma start-up, plasma heating and suppression of Neoclassical Tearing Modes (NTMs). These applications are accomplished using 27 one megawatt continuous wave gyrotrons: 24 at a frequency of 170 GHz and 3 at a frequency of 120 GHz. There are DC power supplies for the gyrotrons, a transmission line system, one launcher at the equatorial plane and three upper port launchers. The US will play a major role in delivering parts of the ECH&CD system to ITER. The present state-of-the-art includes major advances in all areas of ECH technology. In the US, a major effort is underway to supply gyrotrons of up to 1.5 MW power level at 110 GHz to General Atomics for use in heating the DIII-D tokamak. This presentation will include a brief review of the state-of-the-art, worldwide, in ECH technology. The requirements for the ITER ECH&CD system will then be reviewed. ITER calls for gyrotrons capable of operating from a 50 kV power supply, after potential depression, with a minimum of 50% overall efficiency. This is a very significant challenge and some approaches to meeting this goal will be presented. Recent experimental results at MIT showing improved efficiency of high frequency, 1.5 MW gyrotrons will be described. These results will be incorporated into the planned development of gyrotrons for ITER. The ITER ECH&CD system will also be a challenge to the transmission lines, which must operate at high average power at up to 1000 seconds and with high efficiency. The technology challenges and efforts in the US and other ITER parties to solve these problems will be reviewed. *In collaboration with E. Choi, C. Marchewka, I. Mastovosky, M. A. Shapiro and R. J. Temkin. This work is supported by the Office of Fusion Energy Sciences of the U. S. Department of Energy.

Effect of Schizonepeta tenuifolia extract on mast cell-mediated immediate-type hypersensitivity in rats.

Science.gov (United States)

Shin, T Y; Jeong, H J; Jun, S M; Chae, H J; Kim, H R; Baek, S H; Kim, H M

1999-11-01

We investigated the effect of an aqueous extract of Schizonepeta tenuifolia (STAE) on mast cell-mediated immediate-type hypersensitivity. STAE inhibited systemic allergic reaction induced by compound 48/80 in rats dose-dependently. STAE also inhibited plasma histamine levels induced by compound 48/80. STAE inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE. In addition, STAE does-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. However, STAE had a significant enhancing effect on anti-DNP IgE-induced tumor necrosis factor-alpha (TNF-alpha) production from RPMC. These results indicate that STAE inhibits immediate-type hypersensitivity and suggest that STAE can selectively activate the TNF-alpha production from RPMC.

Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.

Directory of Open Access Journals (Sweden)

Fernanda M Cerqueira

2011-03-01

Full Text Available Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR. Since treatment of mice with dinitrophenol (DNP promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it could also impact biogenesis. We found that DNP and CR increase citrate synthase activity, PGC-1α, cytochrome c oxidase and mitofusin-2 expression, as well as fasting plasma levels of NO• products. In addition, eNOS and Akt phosphorylation in skeletal muscle and visceral adipose tissue was activated in fasting CR and DNP animals. Overall, our results indicate that systemic mild uncoupling activates eNOS and Akt-dependent pathways leading to mitochondrial biogenesis.

Recent Upgrades and Extensions of the ASDEX Upgrade ECRH System

Science.gov (United States)

Wagner, Dietmar; Stober, Jörg; Leuterer, Fritz; Monaco, Francesco; Münich, Max; Schmid-Lorch, Dominik; Schütz, Harald; Zohm, Hartmut; Thumm, Manfred; Scherer, Theo; Meier, Andreas; Gantenbein, Gerd; Flamm, Jens; Kasparek, Walter; Höhnle, Hendrik; Lechte, Carsten; Litvak, Alexander G.; Denisov, Gregory G.; Chirkov, Alexey; Popov, Leonid G.; Nichiporenko, Vadim O.; Myasnikov, Vadim E.; Tai, Evgeny M.; Solyanova, Elena A.; Malygin, Sergey A.

2011-03-01

The multi-frequency Electron Cyclotron Heating (ECRH) system at the ASDEX Upgrade tokamak employs depressed collector gyrotrons, step-tunable in the range 105-140 GHz. The system is equipped with a fast steerable launcher allowing for remote steering of the ECRH RF beam during the plasma discharge. The gyrotrons and the mirrors are fully integrated in the discharge control system. The polarization can be controlled in a feed-forward mode. 3 Sniffer probes for millimeter wave stray radiation detection have been installed.

Dispersion of helically corrugated waveguides: Analytical, numerical, and experimental study

International Nuclear Information System (INIS)

Burt, G.; Ronald, K.; Young, A.R.; Phelps, A.D.R.; Cross, A.W.; Konoplev, I.V.; He, W.; Thomson, J.; Whyte, C.G.; Samsonov, S.V.; Denisov, G.G.; Bratman, V.L.

2004-01-01

Helically corrugated waveguides have recently been studied for use in various applications such as interaction regions in gyrotron traveling-wave tubes and gyrotron backward-wave oscillators and as a dispersive medium for passive microwave pulse compression. The paper presents a summary of various methods that can be used for analysis of the wave dispersion of such waveguides. The results obtained from an analytical approach, simulations with the three-dimensional numerical code MAGIC, and cold microwave measurements are analyzed and compared

Effects of curcumin on TTX-R sodium currents of dorsal root ganglion neurons in type 2 diabetic rats with diabetic neuropathic pain.

Science.gov (United States)

Meng, Bo; Shen, Lu-Lu; Shi, Xiao-Ting; Gong, Yong-Sheng; Fan, Xiao-Fang; Li, Jun; Cao, Hong

2015-09-25

Type 2 diabetic mellitus (T2DM) has reached pandemic status and shows no signs of abatement. Diabetic neuropathic pain (DNP) is generally considered to be one of the most common complications of T2DM, which is also recognized as one of the most difficult types of pain to treat. As one kind of peripheral neuropathic pain, DNP manifests typical chronic neuralgia symptoms, including hyperalgesia, allodynia, autotomy, and so on. The injured dorsal root ganglion (DRG) is considered as the first stage of the sensory pathway impairment, whose neurons display increased frequency of action potential generation and increased spontaneous activities. These are mainly due to the changed properties of voltage-gated sodium channels (VGSCs) and the increased sodium currents, especially TTX-R sodium currents. Curcumin, one of the most important phytochemicals from turmeric, has been demonstrated to effectively prevent and/or ameliorate diabetic mellitus and its complications including DNP. The present study demonstrates that the TTX-R sodium currents of small-sized DRG neurons isolated from DNP rats are significantly increased. Such abnormality can be efficaciously ameliorated by curcumin. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Resonance-inclined optical nuclear spin polarization of liquids in diamond structures

Science.gov (United States)

Chen, Q.; Schwarz, I.; Jelezko, F.; Retzker, A.; Plenio, M. B.

2016-02-01

Dynamic nuclear polarization (DNP) of molecules in a solution at room temperature has the potential to revolutionize nuclear magnetic resonance spectroscopy and imaging. The prevalent methods for achieving DNP in solutions are typically most effective in the regime of small interaction correlation times between the electron and nuclear spins, limiting the size of accessible molecules. To solve this limitation, we design a mechanism for DNP in the liquid phase that is applicable for large interaction correlation times. Importantly, while this mechanism makes use of a resonance condition similar to solid-state DNP, the polarization transfer is robust to a relatively large detuning from the resonance due to molecular motion. We combine this scheme with optically polarized nitrogen-vacancy (NV) center spins in nanodiamonds to design a setup that employs optical pumping and is therefore not limited by room temperature electron thermal polarization. We illustrate numerically the effectiveness of the model in a flow cell containing nanodiamonds immobilized in a hydrogel, polarizing flowing water molecules 4700-fold above thermal polarization in a magnetic field of 0.35 T, in volumes detectable by current NMR scanners.

Evaluation of uptake and systemicity of 14C - fosthiazate in tomato (Lycopersicon esculentum L.)

International Nuclear Information System (INIS)

Mukherjee, Santanu; Srivastava, Anjana; Kumar, Surendra; Srivastava, P.C.

2009-01-01

Nematodes are round worm species that are found in almost all habitats. Beneficial species are usually referred to free living nematodes, other nematode species are parasitic and harmful to plants, animals and humans. Soil provides an excellent habitat for nematodes. Plant parasitic nematodes may live within plant roots or inhabit in the rhizosphere. The percent yield loss due to root knot nematodes in vegetable crops has been studied under All India Co-ordinated Research Project (Nematodes). The fosthiazate is a new compound incorporated in the market. The uptake and systemicity of fosthiazate in intact tomato plants was studied through 14 C-labeled fosthiazate in presence and absence of DNP. It was found that fosthiazate function as a systemic nematicide in tomato, the accumulation rate of fosthiazate was found higher in roots and shoots part upto 15 hrs. uptake period and after that accumulation slowly becomes saturated in the absence of DNP. In the presence of DNP (10 -2 mM) the amount of fosthiazate in roots as well as shoots was found to be decreased with respect to the uptake time.There was more inhibition on the uptake of fosthiazate in shoots than roots by DNP. (author)

Start-effect measurement of high FEL [free-electron laser] electric fields in MTX [Microwave Tokamak Experiment] by laser-aided particle-probe spectroscopy

International Nuclear Information System (INIS)

Oda, T.; Takiyama, K.; Odajima, K.; Ohasa, K.; Shiho, M.; Mizuno, K.; Foote, J.H.; Nilson, D.G.

1990-01-01

We are constructing a diagnostic system to measure the electric field (>100 kV/cm) of a free-electron laser (FEL) beam when injected into the plasma of the Microwave Tokamak Experiment (MTX). The apparatus allows a crossed-beam measurement, with 2-cm spatial resolution in the plasma, involving the FEL beam (with 140-GHz, ∼1-GW ECH pulses), a neutral-helium beam, and a dye-laser beam. After the laser beam pumps metastable helium atoms to higher excited states, their decay light is detected by an efficient optical system. Because of the Stark effect arising from the FEL electric field (rvec E), a forbidden transition can be strongly induced. The intensity of emitted light resulting from the forbidden transition is proportional to E 2 . Because photon counting rates are estimated to be low, extra effort is made to minimize background and noise levels. It is possible that the lower rvec E of an MTX gyrotron-produced ECH beam with its longer-duration pulses can also be measured using this method. Other applications of the apparatus described here may include measurements of ion temperature (using charge-exchange recombination), edge-density fluctuations, and core impurity concentrations

Quantum mechanical aspects of dynamical neutron polarization

International Nuclear Information System (INIS)

Betz, T.; Badurek, G.; Jericha, E.

2007-01-01

Dynamic Neutron Polarization (DNP) is a concept which allows to achieve complete polarization of slow neutrons, virtually without any loss of intensity. There the neutrons pass through a combination of a static and a rotating magnetic field in resonance, like in a standard NMR apparatus. Depending on their initial spin state, they end up with different kinetic energies and therefore different velocity. In a succeeding magnetic precession field this distinction causes a different total precession angle. Tuning the field strength can lead to a final state where two original anti-parallel spin states are aligned parallel and hence to polarization. The goal of this work is to describe the quantum mechanical aspects of DNP and to work out the differences to the semi-classical treatment. We show by quantum mechanical means, that the concept works and DNP is feasible, indeed. Therefore, we have to take a closer look to the behavior of neutron wave functions in magnetic fields. In the first Section we consider a monochromatic continuous beam. The more realistic case of a pulsed, polychromatic beam requires a time-dependent field configuration and will be treated in the second Section. In particular the spatial separation of the spin up- and down-states is considered, because it causes an effect of polarization damping so that one cannot achieve a fully polarized final state. This effect is not predicted by the semi-classical treatment of DNP. However, this reduction of polarization is very small and can be neglected in realistic DNP-setups

Exploitation of a diamagnetic loop for modulated ECH power absorption measurements in TCV

International Nuclear Information System (INIS)

Manini, A.; Moret, J.M.; Alberti, S.; Goodman, T.P.; Henderson, M.A.

2003-01-01

For the evaluation of the performance of auxiliary heating methods and for the understanding of the transport properties of auxiliary heated plasmas, it is of fundamental importance to determine the fraction of the launched power that is actually transferred to the plasma, as well as where in the plasma the power is deposited. The diagnostic which is probably the best suited for the first goal is the Diamagnetic Loop (DML) providing a measurement of the diamagnetic flux of the plasma, which is directly related to the total plasma kinetic energy. TCV is equipped with a very versatile Electron Cyclotron Heating (ECH) system. It consists of six gyrotrons operating at the second harmonic, 82.7 GHz, and three gyrotrons at the third harmonic, 118 GHz. The nominal power for each 82.7 GHz gyrotron is 465 kW and for each 118 GHz gyrotron is 480 kW, resulting in a total of radio frequency power of 4.2 MW. In this paper we present the method that has been developed for determining the absorbed power in the ECH experiments in TCV, pointing out especially the results of the first third harmonic X-Mode (X3) ECH experiments, leaving the problem of the power deposition localisation to other reports. For the determination of the total plasma kinetic energy, the DML has also been used on other devices such as JET, ASDEX and TEXTOR, but only for this last case modulation experiments have been performed and analysed. Modulated ECH has been used to determine the ECH X2 and X3 power absorption from the measurement of the diamagnetic flux variations using the DML. Since only the modulation contribution is relevant to the analysis, the method does not require a perfect compensation of the diamagnetic flux measurement, although a good compensation of the vessel poloidal image current is crucial for ensuring a sufficiently large bandwidth to allow the use of high frequency modulation. The analysis of the behaviour of the amplitude and phase response in the modulation frequency scan has

Antigen-decorated shell cross-linked nanoparticles: synthesis, characterization, and antibody interactions.

Science.gov (United States)

Joralemon, Maisie J; Smith, Norah L; Holowka, David; Baird, Barbara; Wooley, Karen L

2005-01-01

Antigen-decorated shell cross-linked knedel-like nanoparticles (SCKs) were synthesized and studied as multivalent nanoscale surfaces from which antibody-binding units were presented in a manner that was designed to approach virus particle surfaces. The SCK nanostructures were fabricated with control over the number of antigenic groups, from mixed micellization of amphiphilic diblock copolymer building blocks that contained either an antigen (2,4-dinitrophenyl) or an ethylpropionate group at the hydrophilic alpha-chain terminus. Amphiphilic diblock copolymers were synthesized by atom transfer radical polymerization of tert-butyl acrylate and methyl acrylate sequentially from either a 2,4-dinitrophenyl-functionalized initiator or ethyl 2-bromopropionate, followed by selective removal of the tert-butyl groups to afford 2,4-dinitrophenyl-poly(acrylic acid)60-b-poly(methyl acrylate)60 (DNP-PAA(60)-b-PMA60) and poly(acrylic acid)70-b-poly(methyl acrylate) (PAA70-b-PMA70). Micelles were assembled via addition of water to THF solutions of the polymers in 0:1, 1:1, and 1:0 molar ratios of DNP-PAA60-b-PMA60 to PAA70-b-PMA70, followed by dialysis against water. The acrylic acid groups of the micelle coronas were partially cross-linked (nominally 50%) with 2,2'-(ethylenedioxy)bis(ethylamine), in the presence of 1-(3'-dimethylaminopropyl)-3-ethylcarbodiimide methiodide. Following extensive dialysis against water, the 0%, 50%, and 100% dinitrophenylated shell cross-linked nanoparticles (DNP-SCKs) were characterized with dynamic light scattering (DLS), transmission electron microscopy (TEM), atomic force microscopy (AFM), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), infrared and UV-vis spectroscopies, and analytical ultracentrifugation (AU). The surface accessibility and bioavailability of the DNP units upon the DNP-SCKs were investigated by performing quenching titrations of fluorescein-labeled IgE antibody in solution and degranulation of Ig

Observation of strongly forbidden solid effect dynamic nuclear polarization transitions via electron-electron double resonance detected NMR

Energy Technology Data Exchange (ETDEWEB)

Smith, Albert A.; Corzilius, Björn; Haze, Olesya; Swager, Timothy M.; Griffin, Robert G., E-mail: rgg@mit.edu [Department of Chemistry and Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)

2013-12-07

We present electron paramagnetic resonance experiments for which solid effect dynamic nuclear polarization transitions were observed indirectly via polarization loss on the electron. This use of indirect observation allows characterization of the dynamic nuclear polarization (DNP) process close to the electron. Frequency profiles of the electron-detected solid effect obtained using trityl radical showed intense saturation of the electron at the usual solid effect condition, which involves a single electron and nucleus. However, higher order solid effect transitions involving two, three, or four nuclei were also observed with surprising intensity, although these transitions did not lead to bulk nuclear polarization—suggesting that higher order transitions are important primarily in the transfer of polarization to nuclei nearby the electron. Similar results were obtained for the SA-BDPA radical where strong electron-nuclear couplings produced splittings in the spectrum of the indirectly observed solid effect conditions. Observation of high order solid effect transitions supports recent studies of the solid effect, and suggests that a multi-spin solid effect mechanism may play a major role in polarization transfer via DNP.

Beware the yellow slimming pill: fatal 2,4-dinitrophenol overdose.

Science.gov (United States)

Holborow, Alexander; Purnell, Richard M; Wong, Jenny Frederina

2016-04-04

An industrial chemical, 2,4-dinitrophenol (DNP), has found use as a weight loss drug. It is extremely toxic in overdose and has a narrow therapeutic window with significant interindividual variability in metabolism. The rise in internet-based sales and distribution of this drug has seen an increased incidence of both accidental and intentional overdose presenting to emergency departments across the UK. No antidote currently exists and overdose is often fatal despite management based on current recommendations. We report a case of intentional overdose of DNP in a young man and discuss the current treatment guidelines. The case highlights the need for an increased awareness among frontline medical staff of the effects of DNP poisoning and questions the need for a more aggressive approach in the management of acute toxicity. 2016 BMJ Publishing Group Ltd.

ELMO Bumpy Torus

International Nuclear Information System (INIS)

Berry, L.A.; Hedrick, C.L.; Uckan, N.A.

1979-03-01

The ELMO Bumpy Torus (EBT) program of experiment, theory, and reactor studies has been a remarkably successful one. In the five years since EBT-I began operating, work has progressed from a demonstration of macrostability to an increasingly detailed understanding of transport properties. Collisionless scaling (tau/sub E/ increases with temperature) has been observed, and the magnitude of the energy confinement time is consistent with neoclassical theory. Experiments on EBT-S (for scale) are now being conducted at the increased magnetic field levels and higher microwave power and frequency made possible by a 28-GHz gyrotron development program. A review of the program is given

High-power microwave transmission and launching systems for fusion plasma heating systems

International Nuclear Information System (INIS)

Bigelow, T.S.

1989-01-01

Microwave power in the 30- to 300-GHz frequency range is becoming widely used for heating of plasma in present-day fusion energy magnetic confinement experiments. Microwave power is effective in ionizing plasma and heating electrons through the electron cyclotron heating (ECH) process. Since the power is absorbed in regions of the magnetic field where resonance occurs and launching antennas with narrow beam widths are possible, power deposition location can be highly controlled. This is important for maximizing the power utilization efficiency and improving plasma parameters. Development of the gyrotron oscillator tube has advanced in recent years so that a 1-MW continuous-wave, 140-GHz power source will soon be available. Gyrotron output power is typically in a circular waveguide propagating a circular electric mode (such as TE 0,2 ) or a whispering-gallery mode (such as TE 15,2 ), depending on frequency and power level. An alternative high-power microwave source currently under development is the free-electron laser (FEL), which may be capable of generating 2-10 MW of average power at frequencies of up to 500 GHz. The FEL has a rectangular output waveguide carrying the TE 0,1 mode. Because of its higher complexity and cost, the high-average-power FEL is not yet as extensively developed as the gyrotron. In this paper, several types of operating ECH transmission systems are discussed, as well systems currently being developed. The trend in this area is toward higher power and frequency due to the improvements in plasma density and temperature possible. Every system requires a variety of components, such as mode converters, waveguide bends, launchers, and directional couplers. Some of these components are discussed here, along with ongoing work to improve their performance. 8 refs

Quasi-optical techniques for ECRH

International Nuclear Information System (INIS)

Andenaerde, K.; Beyer, J.; Vernon, R.

1985-01-01

The status of research at Wisconsin on quasi-optical launchers for ECRH is presented. Wengenroth's mode transducing antenna has been investigated theoretically. Agreement with experiment using TE 01 excitation is excellent, and the theory has been expanded to include TE 02 and TE 03 excitation as well. A system incorporating such and similar mode transducing antennas with a Cassegrain system will combine the output of various gyrotrons. A device to test this and similar concepts is being built and has been preliminarily tested for mode purity

Novel design for centrifugal counter-current chromatography: VI. Ellipsoid column.

Science.gov (United States)

Gu, Dongyu; Yang, Yi; Xin, Xuelei; Aisa, Haji Akber; Ito, Yoichiro

2015-01-01

A novel ellipsoid column was designed for centrifugal counter-current chromatography. Performance of the ellipsoid column with a capacity of 3.4 mL was examined with three different solvent systems composed of 1-butanol-acetic acid-water (4:1:5, v/v) (BAW), hexane-ethyl acetate-methanol-0.1 M HCl (1:1:1:1, v/v) (HEMH), and 12.5% (w/w) PEG1000 and 12.5% (w/w) dibasic potassium phosphate in water (PEG-DPP) each with suitable test samples. In dipeptide separation with BAW system, both stationary phase retention (Sf) and peak resolution (Rs) of the ellipsoid column were much higher at 0° column angle (column axis parallel to the centrifugal force) than at 90° column angle (column axis perpendicular to the centrifugal force), where elution with the lower phase at a low flow rate produced the best separation yielding Rs at 2.02 with 27.8% Sf at a flow rate of 0.07 ml/min. In the DNP-amino acid separation with HEMW system, the best results were obtained at a flow rate of 0.05 ml/min with 31.6% Sf yielding high Rs values at 2.16 between DNP-DL-glu and DNP-β-ala peaks and 1.81 between DNP-β-ala and DNP-L-ala peaks. In protein separation with PEG-DPP system, lysozyme and myolobin were resolved at Rs of 1.08 at a flow rate of 0.03 ml/min with 38.9% Sf. Most of those Rs values exceed those obtained from the figure-8 column under similar experimental conditions previously reported.

An approach to clinical data management for the doctor of nursing practice curriculum.

Science.gov (United States)

Sylvia, Martha; Terhaar, Mary

2014-01-01

Strong data management skills are essential to doctor of nursing practice (DNP) education and necessary for DNP practice. Completion of the DNP scholarly project requires application of these skills to understand and address a complex practice, process, or systems problem; develop, implement, and monitor an innovative evidence-based intervention to address that problem; and evaluate the outcomes. The purposes of this paper were to describe the demand and context for clinical data management (CDM) within the DNP curriculum; provide an overview of CDM content; describe the process for content delivery; propose a set of course objectives; and describe initial successes and challenges. A two-pronged approach of consultation and a CDM course were developed. Students who participated in this approach were more likely to create and implement an evaluation plan; apply techniques for data cleansing and manipulation; apply concepts of sample size determination using power analysis; use exploratory data analysis techniques to understand population attributes and sampling bias; apply techniques to adjust for bias; apply statistical significance testing; and present project results in a meaningful way. On the basis of this evaluation, CDM has evolved from an elective to a required course integrated in a thread that crosses the entire curriculum. Copyright © 2014 Elsevier Inc. All rights reserved.

A 282 GHz Probe for Dynamic Nuclear Polarization

DEFF Research Database (Denmark)

Rybalko, Oleksandr; Bowen, Sean; Zhurbenko, Vitaliy

Introduction In DNP, microwave irradiation of a sample facilitates the transfer of spin polarization from electrons tonuclei. One of the way to improve the DNP enhancement is to transfer microwave power from the mm-wave source tothe sample more effectively. Several methods and techniques to effic......Introduction In DNP, microwave irradiation of a sample facilitates the transfer of spin polarization from electrons tonuclei. One of the way to improve the DNP enhancement is to transfer microwave power from the mm-wave source tothe sample more effectively. Several methods and techniques......: microwave can with RF coil; the rest of the probe consists of a waveguide, sample tube and coaxial transmission line. The probe is designed to study cylindrical samples with diameter - 9 mm, and height – 2-20 mm. An RF coil which is housed in cylindrical Macor coil form (dielectric with ε=5.64 and tangent δ...... is 0.0025) surrounds the sample. The RF coil has a saddle form and was madeout of two current loops run on opposite sides of a cylinder (in parallel). Material of the coil is copper wire with diameterequal to 0.7 mm. Coil dimensions are: diameter - 13 mm; height - 22.0 mm. The self resonant frequency...

Deoxyribonucleoside kinases in mitochondrial DNA depletion.

Science.gov (United States)

Saada-Reisch, Ann

2004-10-01

Mitochondrial DNA (mtDNA) depletion syndromes (MDS) are a heterogeneous group of mitochondrial disorders, manifested by a decreased mtDNA copy number and respiratory chain dysfunction. Primary MDS are inherited autosomally and may affect a single organ or multiple tissues. Mutated mitochondrial deoxyribonucleoside kinases; deoxyguanosine kinase (dGK) and thymidine kinase 2 (TK2), were associated with the hepatocerebral and myopathic forms of MDS respectively. dGK and TK2 are key enzymes in the mitochondrial nucleotide salvage pathway, providing the mitochondria with deoxyribonucleotides (dNP) essential for mtDNA synthesis. Although the mitochondrial dNP pool is physically separated from the cytosolic one, dNP's may still be imported through specific transport. Non-replicating tissues, where cytosolic dNP supply is down regulated, are thus particularly vulnerable to dGK and TK2 deficiency. The overlapping substrate specificity of deoxycytidine kinase (dCK) may explain the relative sparing of muscle in dGK deficiency, while low basal TK2 activity render this tissue susceptible to TK2 deficiency. The precise pathophysiological mechanisms of mtDNA depletion due to dGK and TK2 deficiencies remain to be determined, though recent findings confirm that it is attributed to imbalanced dNTP pools.

Research on Gyrotrons.

Science.gov (United States)

1985-04-15

8217 ) (2N’n I roBo )2wL(I - I/vo)exptEo2(aw/w) 2/2j { 2(kp , /mor4) 2("-1t[ 0 2L~o2 ( A/,’w)/2 - n ](2 TQV) ’, (1) C mw)m, = [n + (n2 + 42 .,4)i2 I/ 2 2...Acknowledgement The author would like to express his gratitude to his advisor , Professor Jay L. Hirshfield, for the indefatigable scientific discussion which

Identification of oxidised proteins in the matrix of rice leaf mitochondria by immunoprecipitation and two-dimensional liquid chromatography-tandem mass spectrometry

DEFF Research Database (Denmark)

Kristensen, B.K.; Askerlund, P.; Bykova, N.V.

2004-01-01

.2 mM CuSO4 for 10 min at room temperature). The oxidised proteins in both samples were tagged with dinitrophenylhydrazine (DNP), which forms a covalent bond with carbonyl groups. The DNP-tagged proteins were immunoprecipitated using anti-DNP antibodies and digested with trypsin. The mixture...... of peptides was analysed by nano-HPLC coupled online to an ESI-Quad-TOF mass spectrometer. The peptides were separated by stepwise ion exchange chromatography followed by reverse phase chromatography (2D-LC), and analysed by MS/MS. Proteins were identified by un-interpreted fragment ion database searches...... blots showed that neither the isolation of mitochondria, nor their subfractionation introduced carbonyl groups. We therefore conclude that a number of proteins are oxidised in the matrix of rice leaf mitochondria in vivo and further identify a group of proteins that are particularly susceptible to mild...

Dynamic nuclear polarization methods in solids and solutions to explore membrane proteins and membrane systems.

Science.gov (United States)

Cheng, Chi-Yuan; Han, Songi

2013-01-01

Membrane proteins regulate vital cellular processes, including signaling, ion transport, and vesicular trafficking. Obtaining experimental access to their structures, conformational fluctuations, orientations, locations, and hydration in membrane environments, as well as the lipid membrane properties, is critical to understanding their functions. Dynamic nuclear polarization (DNP) of frozen solids can dramatically boost the sensitivity of current solid-state nuclear magnetic resonance tools to enhance access to membrane protein structures in native membrane environments. Overhauser DNP in the solution state can map out the local and site-specific hydration dynamics landscape of membrane proteins and lipid membranes, critically complementing the structural and dynamics information obtained by electron paramagnetic resonance spectroscopy. Here, we provide an overview of how DNP methods in solids and solutions can significantly increase our understanding of membrane protein structures, dynamics, functions, and hydration in complex biological membrane environments.

Reactive surface organometallic complexes observed using dynamic nuclear polarization surface enhanced NMR spectroscopy

KAUST Repository

Pump, Eva; Viger-Gravel, Jasmine; Abou-Hamad, Edy; Samantaray, Manoja; Hamzaoui, Bilel; Gurinov, Andrei; Anjum, Dalaver H.; Gajan, David; Lesage, Anne; Bendjeriou-Sedjerari, Anissa; Emsley, Lyndon; Basset, Jean-Marie

2016-01-01

Dynamic Nuclear Polarization Surface Enhanced NMR Spectroscopy (DNP SENS) is an emerging technique that allows access to high-sensitivity NMR spectra from surfaces. However, DNP SENS usually requires the use of radicals as an exogenous source of polarization, which has so far limited applications for organometallic surface species to those that do not react with the radicals. Here we show that reactive surface species can be studied if they are immobilized inside porous materials with suitably small windows, and if bulky nitroxide bi-radicals (here TEKPol) are used as the polarization source and which cannot enter the pores. The method is demonstrated by obtaining significant DNP enhancements from highly reactive complelxes [(equivalent to Si-O-)W(Me)(5)] supported on MCM-41, and effects of pore size (6.0, 3.0 and 2.5 nm) on the performance are discussed.

Reactive surface organometallic complexes observed using dynamic nuclear polarization surface enhanced NMR spectroscopy

KAUST Repository

Pump, Eva

2016-08-15

Dynamic Nuclear Polarization Surface Enhanced NMR Spectroscopy (DNP SENS) is an emerging technique that allows access to high-sensitivity NMR spectra from surfaces. However, DNP SENS usually requires the use of radicals as an exogenous source of polarization, which has so far limited applications for organometallic surface species to those that do not react with the radicals. Here we show that reactive surface species can be studied if they are immobilized inside porous materials with suitably small windows, and if bulky nitroxide bi-radicals (here TEKPol) are used as the polarization source and which cannot enter the pores. The method is demonstrated by obtaining significant DNP enhancements from highly reactive complelxes [(equivalent to Si-O-)W(Me)(5)] supported on MCM-41, and effects of pore size (6.0, 3.0 and 2.5 nm) on the performance are discussed.

Electron cyclotron heating of plasmas

International Nuclear Information System (INIS)

Guest, Gareth

2009-01-01

As nuclear fusion becomes an increasingly important potential energy source in these times of global oil and energy crises, the development of technologies that can lead to the realization of this virtually inexhaustible source of energy takes on ever greater urgency. Over the past decade electron cyclotron heating has undergone a significant maturation and has emerged as an essential component of the major approaches to achieving controlled nuclear fusion. The gyrotron, first developed in the Soviet Union, has made it possible to employ ECH in large tokamak and stellarator fusion devices by providing megawatts of microwave power at frequencies above 100 GHz. A contemporary VGT-8110 gyrotron, for example, shown here with Kevin Felch and Pat Cahalan of Communications and Power Industries, is capable of delivering 10 second pulses of 1 MW of power at 110 GHz. The present monograph addresses the ECH physics critical to the international fusion reactor experiment, ITER, but also presents the fundamentals of ECH that are essential to its successful implementation in applications that range from active experiments in planetary magnetospheres to commercial plasma sources for the manufacture of computer chips. The book seeks to convey the physics of ECH in an orderly and coherent fashion to a professional audience by presenting the basic theoretical foundations and then using the theory to interpret a number of established experimental results. Exercises are included to aid the reader in making the theory more concrete. (orig.)

Performance of the TJ-II ECRH system with the new -80 kV 50 A high voltage power supply

International Nuclear Information System (INIS)

Fernandez, A.; de la Fuente, J.M.; Ganuza, D.; Kirpitchev, I.; Alonso, J.; Garcia, F.; Ascasibar, E.; del Rio, J.M.; Garcia, I.; Ros, A.; Alvarez, P.; Tolkachev, A.; Catalan, G.

2009-01-01

The ECRH system of the TJ-II stellarator consists of two triode - 53.2 GHz - gyrotrons, which can deliver a maximum power of 300 kW each, during 1 s. Both gyrotrons are fed by a common high voltage power supply (HVPS). During the last experimental campaigns the performance of the gyrotrons were limited by the HVPS, whose maximum output current was limited to 30 A and the ripple level of the output voltage was around 7%. In order to guarantee the reliability of the ECRH system and to improve its performance, a new HVPS has been developed and manufactured by the company JEMA and was commissioned at CIEMAT during 2007. The design is based on solid-state technology and high frequency commutation techniques. The new unit reaches -80 kV and 50 A during a maximum pulse length of 1 s. The complete design, testing and commissioning of the HVPS are presented, as well as the routine operation of the ECRH system during the TJ-II experimental campaign.

Performance of the TJ-II ECRH system with the new -80 kV 50 A high voltage power supply

Energy Technology Data Exchange (ETDEWEB)

Fernandez, A. [Laboratorio Nacional de Fusion, EURATOM-CIEMAT Association, Avda. Complutense 22, 28040 Madrid (Spain)], E-mail: angela.curto@ciemat.es; de la Fuente, J.M.; Ganuza, D. [Grupo JEMA, Paseo del Circuito 10, 20160 Lasarte-Oria (Spain); Kirpitchev, I.; Alonso, J. [Laboratorio Nacional de Fusion, EURATOM-CIEMAT Association, Avda. Complutense 22, 28040 Madrid (Spain); Garcia, F. [Grupo JEMA, Paseo del Circuito 10, 20160 Lasarte-Oria (Spain); Ascasibar, E. [Laboratorio Nacional de Fusion, EURATOM-CIEMAT Association, Avda. Complutense 22, 28040 Madrid (Spain); del Rio, J.M.; Garcia, I. [Grupo JEMA, Paseo del Circuito 10, 20160 Lasarte-Oria (Spain); Ros, A.; Alvarez, P.; Tolkachev, A.; Catalan, G. [Laboratorio Nacional de Fusion, EURATOM-CIEMAT Association, Avda. Complutense 22, 28040 Madrid (Spain)

2009-06-15

The ECRH system of the TJ-II stellarator consists of two triode - 53.2 GHz - gyrotrons, which can deliver a maximum power of 300 kW each, during 1 s. Both gyrotrons are fed by a common high voltage power supply (HVPS). During the last experimental campaigns the performance of the gyrotrons were limited by the HVPS, whose maximum output current was limited to 30 A and the ripple level of the output voltage was around 7%. In order to guarantee the reliability of the ECRH system and to improve its performance, a new HVPS has been developed and manufactured by the company JEMA and was commissioned at CIEMAT during 2007. The design is based on solid-state technology and high frequency commutation techniques. The new unit reaches -80 kV and 50 A during a maximum pulse length of 1 s. The complete design, testing and commissioning of the HVPS are presented, as well as the routine operation of the ECRH system during the TJ-II experimental campaign.

Axis-encircling electron beam generation using a smooth magnetic cusp for gyrodevices

International Nuclear Information System (INIS)

He, W.; Whyte, C. G.; Rafferty, E. G.; Cross, A. W.; Phelps, A. D. R.; Ronald, K.; Young, A. R.; Robertson, C. W.; Speirs, D. C.; Rowlands, D. H.

2008-01-01

The generation of an annular-shaped axis-encircling electron beam using a smooth magnetic cusp was studied through numerical simulations and experiments for harmonic operation of a gyrodevice. Two magnetic coils were used to form a magnetic cusp located just downstream from the velvet cathode of an accelerator diode. An electron beam of current 34 A and voltage 130 kV with an adjustable velocity ratio α up to 1.2 was fully transported to the downstream uniform magnetic field region and used to drive a gyrotron traveling wave amplifier into saturation

Polarized targets in high energy physics

Energy Technology Data Exchange (ETDEWEB)

Cates, G.D. Jr. [Princeton Univ., NJ (United States)

1994-12-01

Various approaches are discussed for producing polarized nuclear targets for high energy physics experiments. As a unifying theme, examples are drawn from experiments to measure spin dependent structure functions of nucleons in deep inelastic scattering. This single physics goal has, over roughly two decades, been a driving force in advances in target technology. Actual or planned approaches have included solid targets polarized by dynamic nuclear polarization (DNP), several types of internal targets for use in storage rings, and gaseous {sup 3}He targets polarized by spin-exchange optical pumping. This last approach is the type of target adopted for SLAC E-142, an experiment to measure the spin structure function of the neutron, and is described in detail.

Polarized targets in high energy physics

International Nuclear Information System (INIS)

Cates, G.D. Jr.

1994-01-01

Various approaches are discussed for producing polarized nuclear targets for high energy physics experiments. As a unifying theme, examples are drawn from experiments to measure spin dependent structure functions of nucleons in deep inelastic scattering. This single physics goal has, over roughly two decades, been a driving force in advances in target technology. Actual or planned approaches have included solid targets polarized by dynamic nuclear polarization (DNP), several types of internal targets for use in storage rings, and gaseous 3 He targets polarized by spin-exchange optical pumping. This last approach is the type of target adopted for SLAC E-142, an experiment to measure the spin structure function of the neutron, and is described in detail

2,4-Dinitrophenol: A threat to Chinese body-conscious groups

Directory of Open Access Journals (Sweden)

Han Chih Hencher Lee

2014-08-01

Full Text Available 2,4-Dinitrophenol (2,4-DNP, a yellowish compound, has historically been used in the manufacture of dyes, explosives, and fungicides. As it uncouples mitochondrial oxidative phosphorylation, the compound was also used as an antiobesity agent early in the past century. The compound was subsequently banned by the United States Food and Drug Administration in 1938 due to its potentially fatal adverse effects, including hyperthermia, cataract, agranulocytosis, hepatoxicity, nephrotoxicity, and cardiotoxicity. However, the popularity of 2,4-DNP as a slimming aid has appeared to increase again in recent years. The Hong Kong Hospital Authority Toxicology Reference Laboratory recently confirmed two cases of self-administered 2,4-DNP with different clinical presentations to hospitals in the area. Here we describe those two cases, in an attempt to underscore the potential of misuse of this substance by body-conscious groups among the Chinese population.

E-Mentoring for Doctor of Nursing Practice Students: A Pilot Program.

Science.gov (United States)

Harris, Robin; Birk, Stefanie B; Sherman, Jan

2016-08-01

The growing number of online Doctor of Nursing Practice (DNP) programs, steady attrition rates, and shortage of faculty created an opportunity to explore the use of distance-mediated mentoring. Twenty first-year DNP Nursing Leadership students were matched with DNP-prepared mentors in a formalized e-mentoring program. The Ideal Mentor Scale was used to determine what students desired most from the mentoring relationship in addition to midpoint and end-of-program surveys. Quantitative analysis revealed mentors and mentees found the relationship to be beneficial (p mentors (92%) noted the program supplied adequate resources, and the majority of students would recommend the program. Having a mentor leads to both mentor- and mentee-perceived benefits. Recommendations include continuing to seek ways to improve the communication and commitment between the mentor and mentee in order to receive reciprocal program benefits. [J Nurs Educ. 2016;55(8):458-462.]. Copyright 2016, SLACK Incorporated.

Sex pheromone in the moth Heliothis virescens is produced as a mixture of two pools: de novo and via precursor storage in glycerolipids.

Science.gov (United States)

Foster, Stephen P; Anderson, Karin G; Casas, Jérôme

2017-08-01

Most species of moths use a female-produced volatile sex pheromone, typically produced via de novo fatty acid synthesis in a specialized gland, for communication among mates. While de novo biosynthesis of pheromone (DNP) is rapid, suggesting transient precursor acids, substantial amounts of pheromone precursor (and other) acids are stored, predominantly in triacylglycerols in the pheromone gland. Whether these stored acids are converted to pheromone later or not has been the subject of some debate. Using a tracer/tracee approach, in which we fed female Heliothis virescens U- 13 C-glucose, we were able to distinguish two pools of pheromone, in which precursors were temporally separated (after and before feeding on labeled glucose): DNP synthesized from a mixed tracer/tracee acetyl CoA pool after feeding, and pheromone made from precursor acids primarily synthesized before feeding, which we call recycled precursor fat pheromone (RPP). DNP titer varied from high (during scotophase) to low (photophase) and with presence/absence of pheromone biosynthesis activating neuropeptide (PBAN), in accord with native pheromone titer previously observed. By contrast, RPP was constant throughout the photoperiod and did not change with PBAN presence/absence. The amount of RPP (6.3-10.3 ng/female) was typically much lower than that of DNP, especially during the scotophase (peak DNP, 105 ng/female). We propose an integral role for stored fats in pheromone biosynthesis, in which they are hydrolyzed and re-esterified throughout the photoperiod, with a small proportion of liberated precursor acyl CoAs being converted to pheromone. During the sexually active period, release of PBAN results in increased flux of glucose (from trehalose) and hydrolyzed acids entering the mitochondria, producing acetyl CoA precursor for de novo fat and pheromone biosynthesis. Copyright © 2017 Elsevier Ltd. All rights reserved.

Contribution of tryptophan residues to the combining site of a monoclonal anti dinitrophenyl spin-label antibody

International Nuclear Information System (INIS)

Anglister, J.; Bond, M.W.; Frey, T.; Leahy, D.; Levitt, M.; McConnell, H.M.; Rule, G.S.; Tomasello, J.; Whittaker, M.

1987-01-01

Two Fab fragments of the monoclonal anti dinitrophenyl (DNP) spin-label antibody AN02 were prepared by recombination of specifically deuterated heavy and light chains. In the recombinant H(I)L(II) all the tyrosines and phenylalanines were perdeuterated as were the tryptophan residues of the heavy chain. In the recombinant H(II)L(I) all the tyrosines and phenylalanines were perdeuterated as were the tryptophan residues of the light chain. Saturation of three resonances of H(I)L(II), assigned to tryptophan protons of the light chain, resulted in magnetization transfer to the aromatic proton at position 6 of the DNP ring and to the CH2 protons of the glycines linked to the DNP in a diamagnetic hapten (DNP-DG). Saturation of three resonances of H(II)L(I) assigned to tryptophan protons of the heavy chain resulted in magnetization transfer to the CH2 protons of the glycines in DNP-DG. From the dependence of the magnetization transfer on the irradiation time, the cross relaxation rates between the involved protons were estimated. The inferred distances between these protons of the hapten and certain tryptophan protons are 3-4 A. It is concluded that in the combining site of AN02 there is one tryptophan from the light chain and one tryptophan from the heavy chain that are very near the hapten. When all tyrosines and phenylalanines were perdeuterated and all tryptophan aromatic protons were deuterated except for the protons at positions 2 and 5, titration of the Fab fragments with variable amounts of paramagnetic hapten showed that one proton from the light chain tryptophan is near (less than 7 A) the unpaired electron and that three other protons are significantly closer than 15 A

Contribution of tryptophan residues to the combining site of a monoclonal anti dinitrophenyl spin-label antibody

Energy Technology Data Exchange (ETDEWEB)

Anglister, J.; Bond, M.W.; Frey, T.; Leahy, D.; Levitt, M.; McConnell, H.M.; Rule, G.S.; Tomasello, J.; Whittaker, M.

1987-09-22

Two Fab fragments of the monoclonal anti dinitrophenyl (DNP) spin-label antibody AN02 were prepared by recombination of specifically deuterated heavy and light chains. In the recombinant H(I)L(II) all the tyrosines and phenylalanines were perdeuterated as were the tryptophan residues of the heavy chain. In the recombinant H(II)L(I) all the tyrosines and phenylalanines were perdeuterated as were the tryptophan residues of the light chain. Saturation of three resonances of H(I)L(II), assigned to tryptophan protons of the light chain, resulted in magnetization transfer to the aromatic proton at position 6 of the DNP ring and to the CH2 protons of the glycines linked to the DNP in a diamagnetic hapten (DNP-DG). Saturation of three resonances of H(II)L(I) assigned to tryptophan protons of the heavy chain resulted in magnetization transfer to the CH2 protons of the glycines in DNP-DG. From the dependence of the magnetization transfer on the irradiation time, the cross relaxation rates between the involved protons were estimated. The inferred distances between these protons of the hapten and certain tryptophan protons are 3-4 A. It is concluded that in the combining site of AN02 there is one tryptophan from the light chain and one tryptophan from the heavy chain that are very near the hapten. When all tyrosines and phenylalanines were perdeuterated and all tryptophan aromatic protons were deuterated except for the protons at positions 2 and 5, titration of the Fab fragments with variable amounts of paramagnetic hapten showed that one proton from the light chain tryptophan is near (less than 7 A) the unpaired electron and that three other protons are significantly closer than 15 A.

Internalized insulin-receptor complexes are unidirectionally translocated to chloroquine-sensitive degradative sites. Dependence on metabolic energy

International Nuclear Information System (INIS)

Berhanu, P.

1988-01-01

Insulin receptors on the surface of isolated rat adipocytes were photoaffinity labeled at 12 degrees C with the iodinated photoreactive insulin analogue, 125I-B2 (2-nitro-4-azidophenylacetyl)-des-PheB1-insulin, and the pathways in the intracellular processing of the labeled receptors were studied at 37 degrees C. During 37 degrees C incubations, the labeled 440-kDa insulin receptors were continuously internalized (as assessed by trypsin inaccessibility) and degraded such that up to 50% of the initially labeled receptors were lost by 120 min. Metabolic poisons (0.125-0.75 mM 2,4-dinitrophenol (DNP) and 1-10 mM NaF), which led to dose-dependent depletion of adipocyte ATP pools, inhibited receptor loss, and caused up to 3-fold increase in intracellular receptor accumulation. This effect was due to inhibition of intracellular receptor degradation, and there was no apparent effect of the metabolic poisons on initial internalization of the receptors. Following maximal intracellular accumulation of labeled insulin receptors in the presence of NaF or DNP, removal of these agents resulted in a subsequent, time-dependent degradation of the accumulated receptors. However, when the lysosomotropic agent, chloroquine (0.2 mM), was added immediately following removal of the metabolic poisons, further degradation of the intracellularly accumulated receptors was prevented, suggesting that the chloroquine-sensitive degradation of insulin receptors occurs distal to the site of inhibition by NaF or DNP. To confirm this, maximal intracellular accumulation of labeled receptors was first allowed to occur in the presence of chloroquine and the cells were then washed and reincubated in chloroquine-free media in the absence or presence of NaF or DNP. Under these conditions, degradation of the intracellularly accumulated receptors continued to occur, and NaF or DNP failed to block the degradation

Increasing frequency of severe clinical toxicity after use of 2,4-dinitrophenol in the UK: a report from the National Poisons Information Service.

Science.gov (United States)

Kamour, Ashraf; George, Nathan; Gwynnette, David; Cooper, Gillian; Lupton, David; Eddleston, Michael; Thompson, John Paul; Vale, John Allister; Thanacoody, Harry Krishna Ruben; Hill, Simon; Thomas, Simon Hugh Lynton

2015-05-01

2,4-Dinitrophenol (DNP) increases energy consumption by uncoupling oxidative phosphorylation. Although not licensed as a medicine, it is sometimes used by 'body sculptors' and for weight loss as a 'fat burning' agent. This research was performed to characterise patterns of presentation, clinical features and outcomes of patients reported to the National Poisons Information Service (NPIS) in the UK after exposure to DNP. NPIS telephone enquiry records and user sessions for TOXBASE, the NPIS online information database, related to DNP, were reviewed from 1 January 2007 to 31 December 2013. Of the 30 separate systemic exposures to DNP reported by telephone to NPIS during the study period (27 males, 3 females, with a median age of 23.5 years), there were 3 during 2007-2011 (inclusive), 5 during 2012 and 22 during 2013. TOXBASE user sessions also increased sharply from 6 in 2011 to 35 in 2012 and 331 in 2013. The modes of exposure reported in telephone enquiries were chronic (n=2), acute (n=12) and subacute (n=16). Commonly reported clinical features were fever (47%), tachycardia (43%), sweating (37%), nausea or vomiting (27%), skin discolouration or rash (23%), breathing difficulties (23%), abdominal pain (23%), agitation (13%) and headache (13%). There were five (17%, 95% CI 6.9% to 34%) fatalities, four involving acute overdose. The study indicates a substantial recent increase in clinical presentations with toxicity caused by exposure to DNP in the UK with an associated high mortality. Further steps are needed to warn potential users of the severe and sometimes fatal toxicity that may occur after exposure to this compound. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Effects of electroacupuncture at 2 and 100 Hz on rat type 2 diabetic neuropathic pain and hyperalgesia-related protein expression in the dorsal root ganglion.

Science.gov (United States)

He, Xiao-Fen; Wei, Jun-Jun; Shou, Sheng-Yun; Fang, Jian-Qiao; Jiang, Yong-Liang

To investigate the analgesic effects of electroacupuncture (EA) at 2 and 100 Hz on type 2 diabetic neuropathic pain (DNP) and on the expressions of the P2X3 receptor and calcitonin gene-related peptide (CGRP) in the dorsal root ganglion (DRG). Rat type 2 DNP was induced by a high calorie and high sugar diet fed for 7 weeks, plus a single intraperitoneal injection of streptozotocin (STZ) after 5 weeks. EA at 2 and 100 Hz was carried out once every day after 7 weeks for 7 consecutive days. Body weight, serum fasting insulin (FINS), fasting blood glucose (FBG), insulin sensitivity index (ISI), and paw withdrawal latency (PWL) were measured. The expressions of L4-L6 DRG P2X3 receptors and CGRP were assessed by immunofluorescence. Type 2 DNP was successfully induced as shown by the increased body weight, FINS, and FBG, as well as the reduced ISI and PWL. Expressions of P2X3 receptors and CGRP in L4-L6 DRGs increased. EA at both 2 and 100 Hz relieved type 2 DNP, but the analgesic effect of EA was stronger at 2 Hz. P2X3 receptor expression decreased in L4-L6 DRGs following EA at 2 Hz and in L5 and L6 DRGs following EA at 100 Hz. EA at both 2 and 100 Hz down-regulated CGRP overexpression in L4-L6 DRGs. These findings indicate that EA at 2 Hz is a good option for the management of type 2 DNP. The EA effect may be related to its down-regulation of the overexpressions of the DRG P2X3 receptors and CGRP in this condition.

Chemoselective Hydrogenation with Supported Organoplatinum(IV) Catalyst on Zn(II)-Modified Silica

Energy Technology Data Exchange (ETDEWEB)

Camacho-Bunquin, Jeffrey [Chemical Sciences and Engineering Division, Argonne National Laboratory, 9700 S Cass Avenue, Lemont, Illinois 60439, United States; Ferrandon, Magali [Chemical Sciences and Engineering Division, Argonne National Laboratory, 9700 S Cass Avenue, Lemont, Illinois 60439, United States; Sohn, Hyuntae [Chemical Sciences and Engineering Division, Argonne National Laboratory, 9700 S Cass Avenue, Lemont, Illinois 60439, United States; Yang, Dali [Chemical Sciences and Engineering Division, Argonne National Laboratory, 9700 S Cass Avenue, Lemont, Illinois 60439, United States; Liu, Cong [Chemical Sciences and Engineering Division, Argonne National Laboratory, 9700 S Cass Avenue, Lemont, Illinois 60439, United States; Ignacio-de Leon, Patricia Anne [Energy Sciences Division, Argonne National Laboratory, 9700 S Cass Avenue, Lemont, Illinois 60439, United States; Perras, Frédéric A. [Ames Laboratory, U.S. Department of Energy, Ames, Iowa 50010, United States; Pruski, Marek [Ames Laboratory, U.S. Department of Energy, Ames, Iowa 50010, United States; Department of Chemistry, Iowa State University, 2416 Pammel Drive, Ames, Iowa 50011, United States; Stair, Peter C. [Chemical Sciences and Engineering Division, Argonne National Laboratory, 9700 S Cass Avenue, Lemont, Illinois 60439, United States; Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States; Delferro, Massimiliano [Chemical Sciences and Engineering Division, Argonne National Laboratory, 9700 S Cass Avenue, Lemont, Illinois 60439, United States

2018-02-22

Well-defined organoplatinum(IV) sites were grafted on a Zn(II)-modified SiO2 support via surface organometallic chemistry in toluene at room temperature. Solid-state spectroscopies including XAS, DRIFTS, DRUV-Vis, and solid-state (SS)NMR enhanced by dynamic nuclear polarization (DNP), as well as TPR-H2 and TEM techniques revealed highly dispersed (methylcyclopentadi-enyl)methylplatinum(IV) sites on the surface ((MeCp)PtMe/Zn/SiO2, 1). In addition, computational modelling suggests that the surface reaction of (MeCp)PtMe3 with Zn(II)-modified SiO2 support is thermodynamically favorable (ΔG = -12.4 kcal/mol), likely due to the increased acidity of the hydroxyl group, as confirmed by NH3-TPD and DNP-enhanced 17O{1H} SSNMR. In situ DRIFTS and XAS hydrogenation experiments reveal the formation of a surface Pt(IV)-H upon hydrogenolysis of Pt-Me groups. The heterogenized organoplatinum(IV)-H sites catalyze the selective partial hydrogenation of 1,3-butadiene to butenes (up to 95%) and the reduction of nitrobenzene derivatives to anilines (up to 100%) with excellent tolerance of reduction-sensitive func-tional groups (olefin, carbonyl, nitrile, halogens) under mild reaction conditions.

Design and Development of Layered Security: Future Enhancements and Directions in Transmission

Science.gov (United States)

Shahzad, Aamir; Lee, Malrey; Kim, Suntae; Kim, Kangmin; Choi, Jae-Young; Cho, Younghwa; Lee, Keun-Kwang

2016-01-01

Today, security is a prominent issue when any type of communication is being undertaken. Like traditional networks, supervisory control and data acquisition (SCADA) systems suffer from a number of vulnerabilities. Numerous end-to-end security mechanisms have been proposed for the resolution of SCADA-system security issues, but due to insecure real-time protocol use and the reliance upon open protocols during Internet-based communication, these SCADA systems can still be compromised by security challenges. This study reviews the security challenges and issues that are commonly raised during SCADA/protocol transmissions and proposes a secure distributed-network protocol version 3 (DNP3) design, and the implementation of the security solution using a cryptography mechanism. Due to the insecurities found within SCADA protocols, the new development consists of a DNP3 protocol that has been designed as a part of the SCADA system, and the cryptographically derived security is deployed within the application layer as a part of the DNP3 stack. PMID:26751443

Academic and Institutional Review Board Collaboration to Ensure Ethical Conduct of Doctor of Nursing Practice Projects.

Science.gov (United States)

Foote, Jan M; Conley, Virginia; Williams, Janet K; McCarthy, Ann Marie; Countryman, Michele

2015-07-01

Navigating the regulations to protect human subjects and private health information for Doctor of Nursing Practice (DNP) projects can be a formidable task for students, faculty, and the institutional review board (IRB). Key stakeholders from the University of Iowa College of Nursing and the Human Subjects Office developed a standardized process for DNP students to follow, using a decision algorithm, a student orientation to the human subjects review process conducted by faculty and IRB chairs and staff, and a brief Human Subjects Research Determination form. Over 2 years, 109 students completed the process, and 96.3% of their projects were deemed not to be human subjects research. Every student submitted documentation of adherence to the standardized process. Less time was spent by students, faculty, and the IRB in preparing and processing review requests. The interprofessional collaboration resulted in a streamlined process for the timely review of DNP projects. Copyright 2015, SLACK Incorporated.

Design and Development of Layered Security: Future Enhancements and Directions in Transmission

Directory of Open Access Journals (Sweden)

Aamir Shahzad

2016-01-01

Full Text Available Today, security is a prominent issue when any type of communication is being undertaken. Like traditional networks, supervisory control and data acquisition (SCADA systems suffer from a number of vulnerabilities. Numerous end-to-end security mechanisms have been proposed for the resolution of SCADA-system security issues, but due to insecure real-time protocol use and the reliance upon open protocols during Internet-based communication, these SCADA systems can still be compromised by security challenges. This study reviews the security challenges and issues that are commonly raised during SCADA/protocol transmissions and proposes a secure distributed-network protocol version 3 (DNP3 design, and the implementation of the security solution using a cryptography mechanism. Due to the insecurities found within SCADA protocols, the new development consists of a DNP3 protocol that has been designed as a part of the SCADA system, and the cryptographically derived security is deployed within the application layer as a part of the DNP3 stack.

Unsuitability of using the DNPH-coated solid sorbent cartridge for determination of airborne unsaturated carbonyls

Science.gov (United States)

Ho, Steven Sai Hang; Ho, K. F.; Liu, W. D.; Lee, S. C.; Dai, W. T.; Cao, J. J.; Ip, H. S. S.

2011-01-01

Measurements of aldehydes and ketones are typically conducted by derivatization using sorbent cartridges coated with 2,4-dinitrophenylhydrazine (DNPH). The collected samples are eluted with acetonitrile and analyzed by high-pressure liquid chromatography coupled with an ultra-violet detector (HPLC/UV). This paper intends to examine artifacts about its suitability in identification of unsaturated carbonyls. Kinetic tests for acrolein, crotonaldehyde, methacrolein and methyl vinyl ketone (MVK) showed formations of carbonyl-DNP-hydrazone during sampling, which could further react with DNPH, resulting in undesired UV absorption products [e.g., carbonyl-DNP-hydrazone-DNPH (dimer) and 2(carbonyl-DNP-hydrazone)-DNPH (trimer)]. The dimerization and trimerization occurred for acrolein and MVK whereas only dimerization for crotonaldehyde and methacrolein. The polymerization products undoubtedly affect the integrity of the chromatogram, leading to misidentification and inaccurate quantification. Whether precautions taken during sampling and/or sample treatment could avoid or minimize this artifact has not been thoughtfully investigated. More often, such artifacts are usually overlooked by scientists when the data are reported.

Effect of Nitrooxy Compounds with Different Molecular Structures on the Rumen Methanogenesis, Metabolic Profile, and Methanogenic Community.

Science.gov (United States)

Jin, Wei; Meng, Zhenxiang; Wang, Jing; Cheng, Yanfen; Zhu, Weiyun

2017-08-01

Rumen in vitro fermentation was used to evaluate the capacity of nitrooxy compounds to mitigate rumen methane production. The following three nitrooxy compounds, each with different molecular structures, were evaluated: 2,2-dimethyl-3-(nitrooxy) propanoic (DNP), N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide (NPD), and nitroglycerin (NG). All three compounds substantially decreased the total gas production, methane production, and the acetate:propionate ratio, while increasing hydrogen production. The growth of methanogens was specifically inhibited by all three compounds, without affecting the abundance of bacteria, anaerobic fungi, or protozoa. However, inhibition of methanogenesis required a much higher dose of DNP when compared to NPD or NG. Further investigations were conducted on NG to determine its effects on the methanogenic community. NG reduced the relative abundance of Methanomassiliicoccales, while increasing the relative abundance of Methanobrevibacter and Methanosphaera. Overall, the results suggested that all three of these nitrooxy compounds could specifically inhibit rumen methanogenesis, but NPD and NG were much more efficient than DNP at rumen methane mitigation.

Preionization and start-up in the ISX-B tokamak using electron cyclotron heating at 28 GHz

International Nuclear Information System (INIS)

Kulchar, A.G.; Eldridge, O.C.; England, A.C.

1983-10-01

A 28-GHz gyrotron was used to produce a plasma at the electron cyclotron resonance in the Impurity Study Experiment (ISX-B) tokamak. The influence of the toroidal magnetic field magnitude, error fields, gas pressure, microwave power, microwave pulse length, and microwave timing was studied for experiments with magnetic field and gas only. Also, experiments with preionization followed by capacitor discharges were carried out in which these quantities were varied, as were the capacitor bank voltages. Optimum conditions of preionization for some of the parameters were determined. A theoretical model that adequately reproduces the data is given. Calculations based on this model show the temporal evolution of the electron temperature and density, the neutral density, and the plasma current. The model adequately accounts for present and previous experimental results and can be used to make predictions for future experiments

Klystrons, traveling wave tubes, magnetrons, crossed-field amplifiers, and gyrotrons

CERN Document Server

Gilmour, A S

2011-01-01

Microwave tubes are vacuum electron devices used for the generation and amplification of radio frequencies in the microwave range. An established technology area, the use of tubes remains essential in the field today for high-power applications. The culmination of the author's 50 years of industry experience, this authoritative resource offers you a thorough understanding of the operations and major classes of microwave tubes.Minimizing the use of advanced mathematics, the book places emphasis on clear qualitative explanations of phenomena. This practical reference serves as an excellent intro

Millimetre waves and plasma physics

International Nuclear Information System (INIS)

Brand, G.F.

1999-01-01

Full text: This talk is a review of the plasma-related presentations at the 23rd International Conference on Infrared and Millimeter Waves held at the University of Essex, Colchester, UK 7-11 September 1998. Of most relevance to fusion is the development of high-power sources for electron cyclotron resonance heating and current drive. The requirements for ITER are a total of 50 MW at 170 GHz. The state of the art is illustrated by (a) high-power gyrotrons that deliver 1 MW for 1 s at 170 GHz, and (b) a free-electron maser that has generated millimetre waves for the first time, 730 kW at 200 GHz. A number of papers describe new technologies that allow high powers to be achieved; internal mode converters to convert the whispering-gallery mode generated in the gyrotron cavity into a gaussian beam, depressed collectors to raise the efficiency from 1/3 to better than 1/2, CVD diamond output windows and coaxial gyrotrons with improved mode purity. Other papers describe transmission lines and steerable mirrors. Several papers deal with millimetre-wave plasma diagnostics for fusion such as electron cyclotron emission measurements and reflectometry. (author)

Development program for a 200 kW, CW, 28 GHz gyroklystron. Final report, April 1976-September 1980

International Nuclear Information System (INIS)

Shively, J.; Conner, C.; Evans, S.

1980-01-01

The objective of this program was to develop a microwave amplifier or oscillator capable of producing 200 kW, CW power output at 28 GHz. The use of the gyrotron or cyclotron resonance interaction was pursued. A room temperature hollow core solenoid magnet with an iron case was designed to produce the magnetic field required for electron cyclotron resonance. Three pulsed gyroklystron amplifiers were built providing increasing stable output powers of 6, 65 and 76 kW. A back-up pulsed gyrotron oscillator produced 248 kW. A ceramic cone broadband water load was developed. Tests are described for the various tubes that were developed

Short-term Outcomes following Concussion in the NFL: An 11-year Retrospective Study of Player Release Rate and Financial Loss

Science.gov (United States)

Ramkumar, Prem; Navarro, Sergio Michael

2017-01-01

Objectives: The primary goal of this study was to assess the short-term outcomes among National Football League (NFL) players following concussion in terms of: (1) DNP protocol activation, (2) release rate at one and three years, and (3) mean salary reduction. A secondary goal of the study was to stratify the post-concussive release rate by franchise and player position. Methods: NFL player transaction records and publicly available weekly injury reports from August 2005 to January 2016 for NFL players were analyzed. All players immediately sustaining recorded concussions were evaluated for a change to inactive or do-not-play (DNP) status. The one-year and three-year release rate following concussion was defined as any player transitioning to inactivation, retirement, free agency, or any failure to return for a successive season on the same team’s active roster after one or three years from the initial concussion. Student’s t-test was used to compare release rates between non-concussed and concussed players at one and three years. Mean salary reduction per year following concussion was calculated using publicly available player contracts. Additionally, franchise-level and position-based analyses of the release rate were performed. Results: Of the total 5,451 NFL players retrospectively analyzed over the 11-year period, 373 sustained publicly reported concussions resulting in DNP protocol activation. The release rate of the post-concussive versus non-concussive player was 26% vs. 20% at 1 year (pfranchise to release an athlete following concussion within one and three years. Table 1 reports a position-based analysis in terms of concussion rate, mean salary reduction, and NFL career longevity. Conclusion: Our retrospective study demonstrates that NFL concussions resulting in DNP protocol activation leads to a statistically greater release rate among concussed NFL players than non-concussed players. Released players suffered reduction in year-over-year accumulated

Millimeter wave technology IV and radio frequency power sources; Proceedings of the Meeting, Orlando, FL, May 21, 22, 1987

International Nuclear Information System (INIS)

Wiltse, J.C.; Coleman, J.T.

1987-01-01

The present conference on mm-wave technology and radio-frequency power sources discusses topics in the fields of vacuum devices, mm-wave antennas and transmission lines, mm-wave systems and subsystems, and mm-wave techniques and components. Attention is given to recent experiments with planar orotrons, a high peak power X-band gyroklystron for linear supercolliders, cathode-driven crossed-field amplifiers, multi-MW quasi-optical gyrotrons, the radiation coupling of interinjection-locked oscillators, air-to-air mm-wave communications, mm-wave active and passive sensors for terrain mapping, and mm-wave components for electronically controllable antennas

A new treatment of the heat transport equation with a transport barrier and applications to ECRH experiments in Tore Supra

Energy Technology Data Exchange (ETDEWEB)

Zou, X.L.; Giruzzi, A.G.; Bouquey, F.; Clary, J.; Darbos, C.; Lennholm, M.; Magne, R.; Segui, J.L. [CEA Cadarache, Dept. de Recherches sur la Fusion Controlee, 13 - Saint-Paul-lez-Durance (France); Clemencon, A. [MIT, Electrochemical Energy Laboratory, Cambridge, MA (United States); Guivarch, C. [Ecole Nationale des Ponts et Chaussees, 77 - Marne-la-Vallee (France)

2004-07-01

An exact analytical solution of the electron heat diffusion equation in a cylinder has been found with a step-like diffusion coefficient, plus a monomial increase in the radial direction and a constant damping term. This model is sufficiently general to describe heat diffusion in the presence of a critical gradient threshold or a transport barrier, superimposed to the usual trend of increasing heat diffusivity from the plasma core to the edge. This type of representation allows us to see some well-known properties of heat transport phenomena in a different light. For instance, it has been shown that the contributions of the Eigenmodes to the time dependent solution grow at speeds that depend on the Eigenmode order i.e. at the beginning of the heating phase all the Eigenmodes are equally involved, whereas at the end only the lower order ones are left. This implies, e.g., that high frequency modulation experiments provide a characterization of transport phenomena that is intrinsically different with respect to power balance analysis of a stationary phase. It is particularly useful to analyse power switch on/off events and whenever high frequency modulations are not technically feasible. Low-frequency (1-2 Hz) ECRH modulation experiments have been performed on Tore Supra. A large jump (a factor of 8) in the heat diffusivity has been clearly identified at the ECRH power deposition layer. The amplitude and phase of several harmonics of the Fourier transform of the modulated temperature, as well as the time evolution of the modulated temperature have been reproduced by the analytical solution. The jump is found to be much weaker at lower ECRH power (one gyrotron)

110GHz ECH on DIII-D

International Nuclear Information System (INIS)

Cary, W.P.; Allen, J.C.; Callis, R.W.; Doane, J.L.; Harris, T.E.; Moetler, C.P.; Neren, A.; Prater, P.; Rensen, D.

1992-01-01

This paper reports on a new high power electron cyclotron heating (ECH) system which has been introduced on DIII-D. This system is designed to operate at 110 GHz with a total output power of 2 MW. The system consists of four Varian VGT-8011 gyrotrons (output power of 500 kW), and their associated support equipment. All components have been designed for up to a 10 second pulse duration. The 110 GHz system is intended to further progress in rf current drive experiments on DIII-D when used in conjunction with the existing 60 GHz ECH (1. 6 MW) , and the 30-60 MHz ICH (2MW) systems. H-mode physics, plasma stabilization experiments and transport studies are also to be conducted at 110 GHz

DNP NMR of carbohydrate converting enzymes

DEFF Research Database (Denmark)

Kjeldsen, Christian; Ardenkjær-Larsen, Jan Henrik; Duus, Jens Øllgaard

intermediate, however, this evidence is based on mutant of X-ray crystallography and simulations. As the natural substrate lactose does not have any quaternary carbon with long T1, the unnatural substrate o-nitrophenyl β-D-galactopyranoside was used (figure 1) as the quaternarypositions have T1 relaxations...... of ca. 15 s instead of hydrolysis of this substrate can be seen in figure 2, and another use of this substrate is for optimizing the conditions for a labelled substrate (figure 1), which would further increase the signal and allow monitoring of the carbohydrate...

Competition between modes with different axial structures in gyrotrons

International Nuclear Information System (INIS)

Khutoryan, Eduard M.; Nusinovich, Gregory S.; Sinitsyn, Oleksandr V.

2014-01-01

This study was motivated by some experiments in which it was found that during the voltage rise, instead of expected excitation of a high-frequency parasitic mode, the excitation of a lower-frequency parasitic mode takes place in a certain range of voltages. For explaining this fact, the dependence of start currents of possible competing modes on the beam voltage was carried out in the cold-cavity approximation and by using the self-consistent approach. It was found that in the case of cavities, which consist of the combination of a section of constant radius waveguide and a slightly uptapered waveguide, these two approaches yield completely different results. Thus, experimentally observed excitation of the low-frequency parasitic mode can be explained by the self-consistent modification of the axial profile of the excited field, which has strong influence on the diffractive quality factor of competing modes. This modification is especially pronounced in the case of excitation of modes with many axial variations which can be excited in the region of beam interaction with the backward-wave component of such modes

Parametric Cost Modeling of Space Missions Using the Develop New Projects (DMP) Implementation Process

Science.gov (United States)

Rosenberg, Leigh; Hihn, Jairus; Roust, Kevin; Warfield, Keith

2000-01-01

This paper presents an overview of a parametric cost model that has been built at JPL to estimate costs of future, deep space, robotic science missions. Due to the recent dramatic changes in JPL business practices brought about by an internal reengineering effort known as develop new products (DNP), high-level historic cost data is no longer considered analogous to future missions. Therefore, the historic data is of little value in forecasting costs for projects developed using the DNP process. This has lead to the development of an approach for obtaining expert opinion and also for combining actual data with expert opinion to provide a cost database for future missions. In addition, the DNP cost model has a maximum of objective cost drivers which reduces the likelihood of model input error. Version 2 is now under development which expands the model capabilities, links it more tightly with key design technical parameters, and is grounded in more rigorous statistical techniques. The challenges faced in building this model will be discussed, as well as it's background, development approach, status, validation, and future plans.

Synthesis and evaluation of nitroxide-based oligoradicals for low-temperature dynamic nuclear polarization in solid state NMR

Science.gov (United States)

Yau, Wai-Ming; Thurber, Kent R.; Tycko, Robert

2014-07-01

We describe the synthesis of new nitroxide-based biradical, triradical, and tetraradical compounds and the evaluation of their performance as paramagnetic dopants in dynamic nuclear polarization (DNP) experiments in solid state nuclear magnetic resonance (NMR) spectroscopy with magic-angle spinning (MAS). Under our experimental conditions, which include temperatures in the 25-30 K range, a 9.4 T magnetic field, MAS frequencies of 6.2-6.8 kHz, and microwave irradiation at 264.0 GHz from a 800 mW extended interaction oscillator source, the most effective compounds are triradicals that are related to the previously-described compound DOTOPA-TEMPO (see Thurber et al., 2010), but have improved solubility in glycerol/water solvent near neutral pH. Using these compounds at 30 mM total nitroxide concentration, we observe DNP enhancement factors of 92-128 for cross-polarized 13C NMR signals from 15N,13C-labeled melittin in partially protonated glycerol/water, and build-up times of 2.6-3.8 s for 1H spin polarizations. Net sensitivity enhancements with biradical and tetraradical dopants, taking into account absolute 13C NMR signal amplitudes and build-up times, are approximately 2-4 times lower than with the best triradicals.

Restoring penis sensation in patients with low spinal cord lesions: the role of the remaining function of the dorsal nerve in a unilateral or bilateral TOMAX procedure.

Science.gov (United States)

Overgoor, Max L E; Braakhekke, Jan P; Kon, Moshe; De Jong, Tom P V M

2015-04-01

The recently developed TOMAX-procedure restores unilateral genital sensation, improving sexual health in men with a low spinal lesion (LSL). It connects one dorsal nerve of the penis (DNP) to the intact ipsilateral ilioinguinal nerve. We proposed bilateral neurotization for full sensation of the glans but this entails cutting both DNPs, risking patients' erection/ejaculation ability. The objective was to select patients for a bilateral TOMAX-procedure by measuring remaining DNP function, and perform the first bilateral cases. In 30 LSL patients with no penile- but normal groin sensation selected for a unilateral TOMAX-procedure the integrity of the sacral-reflex-arc and DNP function was tested pre-operatively using bilateral needle electromyography (EMG)-bulbocavernosus reflex (BCR) measurements, and an interview about reflex erections (RE) ability. In 13 spina bifida- and 17 spinal cord injury patients [median age 29.5 years (range 13-59 years), spinal lesion T12 (incomplete) to sacral], seven (23%) patients reported RE, four (57%) with intact BCR, and of nine (30%) patients with intact BCR, four reported RE (44%). Even patients with a LSL and no penile sensation can have signs of remaining DNP function, but cutting both DNPs to restore full glans sensation in a bilateral TOMAX-procedure might interfere with their RE/ejaculation. To avoid this risk, we propose a selecting-protocol for a unilateral- or bilateral procedure using RE and BCR measurements. Using this protocol, three patients were bilaterally operated with promising preliminary results. Full sensation of the glans could lead to further improvement in sexual function. © 2014 Wiley Periodicals, Inc.

Prion Replication Elicits Cytopathic Changes in Differentiated Neurosphere Cultures

Science.gov (United States)

Iwamaru, Yoshifumi; Takenouchi, Takato; Imamura, Morikazu; Shimizu, Yoshihisa; Miyazawa, Kohtaro; Mohri, Shirou; Yokoyama, Takashi

2013-01-01

The molecular mechanisms of prion-induced cytotoxicity remain largely obscure. Currently, only a few cell culture models have exhibited the cytopathic changes associated with prion infection. In this study, we introduced a cell culture model based on differentiated neurosphere cultures isolated from the brains of neonatal prion protein (PrP)-null mice and transgenic mice expressing murine PrP (dNP0 and dNP20 cultures). Upon exposure to mouse Chandler prions, dNP20 cultures supported the de novo formation of abnormal PrP and the resulting infectivity, as assessed by bioassays. Furthermore, this culture was susceptible to various prion strains, including mouse-adapted scrapie, bovine spongiform encephalopathy, and Gerstmann-Sträussler-Scheinker syndrome prions. Importantly, a subset of the cells in the infected culture that was mainly composed of astrocyte lineage cells consistently displayed late-occurring, progressive signs of cytotoxicity as evidenced by morphological alterations, decreased cell viability, and increased lactate dehydrogenase release. These signs of cytotoxicity were not observed in infected dNP0 cultures, suggesting the requirement of endogenous PrP expression for prion-induced cytotoxicity. Degenerated cells positive for glial fibrillary acidic protein accumulated abnormal PrP and exhibited features of apoptotic death as assessed by active caspase-3 and terminal deoxynucleotidyltransferase nick-end staining. Furthermore, caspase inhibition provided partial protection from prion-mediated cell death. These results suggest that differentiated neurosphere cultures can provide an in vitro bioassay for mouse prions and permit the study of the molecular basis for prion-induced cytotoxicity at the cellular level. PMID:23740992