WorldWideScience

Sample records for groups c16 planning

  1. Grafting C8-C16 alkyl groups altered the self-assembly and curcumin -loading properties of sodium caseinate in water.

    Science.gov (United States)

    Zhang, Yaqiong; Yang, Puyu; Yao, Fangyi; Liu, Jie; Yu, Liangli Lucy

    2018-02-01

    The data presented here are related to the research article entitled "Synthesis and characterization of alkylated caseinate, and its structure-curcumin loading property relationship in water" (Zhang et al., 2018) [1]. This data article reports the detailed spectra information for 1 H NMR, 13 C NMR and UPLC-Q-TOF MS of the N-succinimidyl fatty acid esters with various alkyl chain lengths (Cn-NHSs, n = 8, 12, 14 and 16). 1 H NMR, 13 C NMR and UPLC-Q-TOF MS spectra for C16-NHS are shown as an example. Then the stacked 1 H NMR spectra of the obtained alkylated caseinates (Cn-caseinates, n = 8, 12, 14 and 16) are provided. The surface hydrophobicity index (S 0 ) of Cn-caseinates with different substitution degrees (SD) of alkyl groups is shown. Additionally, Visual appearances for the formed aqueous dispersions of curcumin-loaded native caseinate (NaCas) and Cn-caseinates self-assemblies are shown. X-ray diffraction patterns of curcumin, C16-caseinate, its physical mixture and curcumin-loaded C16-caseinate self-assemblies are examined. The re-dispersibility and short-term storage stability of the curcumin-loaded NaCas and C16-caseinate self-assemblies are also studied.

  2. Grafting C8-C16 alkyl groups altered the self-assembly and curcumin –loading properties of sodium caseinate in water

    Directory of Open Access Journals (Sweden)

    Yaqiong Zhang

    2018-02-01

    Full Text Available The data presented here are related to the research article entitled “Synthesis and characterization of alkylated caseinate, and its structure-curcumin loading property relationship in water” (Zhang et al., 2018 [1]. This data article reports the detailed spectra information for 1H NMR, 13C NMR and UPLC-Q-TOF MS of the N-succinimidyl fatty acid esters with various alkyl chain lengths (Cn-NHSs, n = 8, 12, 14 and 16. 1H NMR, 13C NMR and UPLC-Q-TOF MS spectra for C16-NHS are shown as an example. Then the stacked 1H NMR spectra of the obtained alkylated caseinates (Cn-caseinates, n = 8, 12, 14 and 16 are provided. The surface hydrophobicity index (S0 of Cn-caseinates with different substitution degrees (SD of alkyl groups is shown. Additionally, Visual appearances for the formed aqueous dispersions of curcumin-loaded native caseinate (NaCas and Cn-caseinates self-assemblies are shown. X-ray diffraction patterns of curcumin, C16-caseinate, its physical mixture and curcumin-loaded C16-caseinate self-assemblies are examined. The re-dispersibility and short-term storage stability of the curcumin-loaded NaCas and C16-caseinate self-assemblies are also studied. Keywords: Caseinate, Alkylated caseinate, Self-assembly, Curcumin-loading property

  3. Resonance states in 16O+16O, 12C+16O, α+ 16O and α+ 12C with ...

    Indian Academy of Sciences (India)

    The resonance states in 16O + 16O, 12C + 16O, + 16O and + 12C are described using modified Morse potential proposed earlier whose success has already been demon-strated in the case of 12C + 12C system. The general validity of such a potential with long range, shallow depth and repulsive soft core determined ...

  4. 7 CFR 275.16 - Corrective action planning.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Corrective action planning. 275.16 Section 275.16... Corrective action planning. (a) Corrective action planning is the process by which State agencies shall...)/management unit(s) in the planning, development, and implementation of corrective action are those which: (1...

  5. Study of the alpha+12C16O capture via 12C(16O,12C)16O transfer reaction

    International Nuclear Information System (INIS)

    Morais, M.C.; Lichtenthaeler, R.; Arazi, A.; Hojman, D.; Cardona, M.A.; Fimiani, L.; Carnelli, P.F.; Marti, G.V.; Pacheco, A.J.; Heimann, D. Martinez; Negri, A.E.; Capurro, O.A.; Niello, J.O. Fernandez; Montero, P.

    2009-01-01

    Full text: The 12 C(α γ) 16 O reaction is one of the most important in nuclear astrophysics. The rate of this reaction influences the subsequent nucleosynthesis of heavier elements in massive stars and consequently determines the stellar evolution. The 12 C(α γ) 16 O reaction cross section is extremely small at stellar temperature, this is mainly due to the Gamow energy (∼ 300KeV at T= 2x10 8 K) be much lower than the Coulomb barrier, E C.B. : = 3:142MeV. The α+ 12 C16 O at low energies is dominated by subthreshold states (1 - , 7:12MeV) and (2 + , 6:92MeV) of the 16 O, thus spectroscopic factors measurements of these states are very important. We propose to use the α-transfer reaction 12 C( 16 O, 12 C) 16 O * at very forward angles to obtain those spectroscopic factors. In this way, measurements of elastic and inelastic angular distributions for the 12 C+ 16 O system were performed at the TANDAR Laboratory in Buenos Aires, using an 16 O beam of E lab = 46.3MeV. These angular distributions were obtained using 8 adjacent surface barrier detectors and the measurements were performed from 5 deg to 48.5 deg with steps of 1 deg. The scattering chamber has an angular precision better than 0.1 deg. The transfer angular distributions are being analysed by DWBA using the computer code FRESCO in order to obtain the two spectroscopic factors. (author)

  6. The Netherlands I: Fiscal Unity, Groupe Steria’s Per-Element Approach and Currency Losses relating to a Non-Resident Subsidiary (C-399/16[X NV]); Starbucks and State Aid (T-760/15 and T-636/16)

    NARCIS (Netherlands)

    Kemmeren, Eric; Lang, Michael; Pistone, Pasquale; Rust, Alexander; Schuch, Josef; Staringer, Claus; Storck, Alfred

    2017-01-01

    In this contribution, the author discusses three cases. The first case, Case C- 399/16 (X NV) is a case which has been inspired by the Groupe Steria decision. The main issue in Case C-399/16 (X NV) is whether the Groupe Steria decision implies that a Dutch resident parent company cannot be denied

  7. Nuclear molecules in the systems 12C+12C and 16O+16O

    International Nuclear Information System (INIS)

    Tiereth, W.

    1986-01-01

    For the two heavy ion systems 12 C+ 12 C and 16 O+ 16 O by means of scattering experiments studies on the phenomena of nuclear molecules were performed. For the 12 C+ 12 C system in the range of the Coulomb wall precision measurements of the elastic scattering were performed. In the two energy ranges of 5.5 ≤ E c.m. ≤ 6.65 MeV and 6.95 ≤ E c.m ≤ 7.375 MeV where the existence of many quasimolecular resonances is known in energy steps of ΔE c.m. = 25 keV angular distributions in the range 10 0 ≤ θ c.m. ≤ 90 0 with Δθ c.m. = 1 0 were measured. For several of the found quasimolecular resonances the spin and the carbon width could be uniquely determined. This was reached by a partial wave analysis of the obtained data. Supplemented were the measurements of the elastic scattering by measurements of the excitation function of the θ 0 exit channel of the reaction 12 ( 12 C, θ) 20 Ne in the energy range from 5.2 ≤ E c.m. ≤ 6.1 MeV. At some known resonances in the 16 O+ 16 O system in the energy range from 15.5 MeV to 18 MeV the spin and the elastic width of these structures could be determined. For this a constrained partial wave analysis on complete angular distributions of the elastic scattering (9 0 ≤ θ c.m. ≤ 90 0 ) which were measured in energy steps of ΔE c.m. = 50 keV was performed. In the 16 O+ 16 O system besides the proof for the existence of a nuclear glory scattering was given. (orig.) [de

  8. 26 CFR 54.9831-1 - Special rules relating to group health plans.

    Science.gov (United States)

    2010-04-01

    ... this section. In addition, benefits provided under a health flexible spending arrangement are excepted... of a group health plan. For purposes of this paragraph (c)(3), benefits are not an integral part of a group health plan (whether the benefits are provided through the same plan or a separate plan) only if...

  9. Grafting C8-C16 alkyl groups altered the self-assembly and curcumin –loading properties of sodium caseinate in water

    OpenAIRE

    Yaqiong Zhang; Puyu Yang; Fangyi Yao; Jie Liu; Liangli (Lucy) Yu

    2018-01-01

    The data presented here are related to the research article entitled “Synthesis and characterization of alkylated caseinate, and its structure-curcumin loading property relationship in water” (Zhang et al., 2018) [1]. This data article reports the detailed spectra information for 1H NMR, 13C NMR and UPLC-Q-TOF MS of the N-succinimidyl fatty acid esters with various alkyl chain lengths (Cn-NHSs, n = 8, 12, 14 and 16). 1H NMR, 13C NMR and UPLC-Q-TOF MS spectra for C16-NHS are shown as an exampl...

  10. 77 FR 8725 - Group Health Plans and Health Insurance Issuers Relating to Coverage of Preventive Services Under...

    Science.gov (United States)

    2012-02-15

    ... regulations authorizing the exemption of group health plans and group health insurance coverage sponsored by... plans and group health insurance issuers on April 16, 2012. FOR FURTHER INFORMATION CONTACT: Amy Turner... addition, information from HHS on private health insurance for consumers can be found on the CMS Web site...

  11. Writing a group practice business plan.

    Science.gov (United States)

    Reiboldt, J M

    1999-07-01

    A business plan offers group practices a blueprint to accomplish a variety of goals, such as securing capital, marketing the practice's services, recruiting new employees, developing a strategic plan or a budget, or planning for growth. A business plan should be informative, specific, and visionary. Elements that every business plan should address are a mission statement, strategy, planning, management information, and action scheme. A business plan should include certain information in a prescribed order. By writing a realistic business plan, group practices can work more efficiently and minimize the risk of not meeting their financial projections.

  12. 17 CFR 240.16c-4 - Derivative securities.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Derivative securities. 240.16c-4 Section 240.16c-4 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED... Exchange Act of 1934 Exemption of Certain Transactions from Section 16(c) § 240.16c-4 Derivative securities...

  13. 17 CFR 240.16c-1 - Brokers.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Brokers. 240.16c-1 Section 240... Act of 1934 Exemption of Certain Transactions from Section 16(c) § 240.16c-1 Brokers. Any transaction... a broker of an order for an account in which the broker has no direct or indirect interest. ...

  14. 16 CFR 240.8 - Need for a plan.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Need for a plan. 240.8 Section 240.8 Commercial Practices FEDERAL TRADE COMMISSION GUIDES AND TRADE PRACTICE RULES GUIDES FOR ADVERTISING ALLOWANCES AND OTHER MERCHANDISING PAYMENTS AND SERVICES § 240.8 Need for a plan. A seller who makes payments...

  15. (16) {C}16C-elastic scattering examined using several models at different energies

    Science.gov (United States)

    El-hammamy, M. N.; Attia, A.

    2018-05-01

    In the present paper, the first results concerning the theoretical analysis of the ^{16}C + p reaction by investigating two elastic scattering angular distributions measured at high energy compared to low energy for this system are reported. Several models for the real part of the nuclear potential are tested within the optical model formalism. The imaginary potential has a Woods-Saxon shape with three free parameters. Two types of density distribution and three different cluster structures for ^{16}C are assumed in the analysis. The results are compared with each other as well as with the experimental data to give evidence of the importance of these studied items.

  16. The change of p16 gene expression in glioma cell line C6 after radiation with gamma knife

    International Nuclear Information System (INIS)

    Zhao Xingli; Zhao Conghai; Tian Yu

    2002-01-01

    Objective: T observe the change of expression of p16 gene product, P16 protein, after treated by gamma knife on glioma cell line C6. Methods: Glioma C6 cells proliferated in vitro, treated by γ-knife in dose of 5.00 and 6.22 Gy, respectively. P16 protein was detected by immunohistochemical technique and image analysis. Results: The P16 protein in glioma C6 cells was notably increased after treatment with γ knife (P < 0.01). The grey number in C6 group (control group) was 167.1 +- 6.2 and was 155.4 +- 2.0 and 124.9 +- 7.1, respectively, in 5.00 Gy and 6.22 Gy gamma knife treated group. Conclusion: It is suggests that one of the mechanisms of glioma cell C6 apoptosis induced by γ-knife radiation may be associated with activation of p16 gene and increase of P16 protein expression

  17. Identification of 16SrIX-C phytoplasmas in Argyranthemum frutescens in Italy

    Directory of Open Access Journals (Sweden)

    Luca FERRETTI

    2015-04-01

    Full Text Available Phytoplasmas are cell wall-less microorganisms associated with plant diseases worldwide. Many important food, vegetable and fruits crops as well as ornamental plants can be severely affected by these pathogens, with significant economic impacts. Phytoplasma diseases of ornamentals have been described worldwide in a wide range of plant genera, and 11 different 16Sr groups have been identified. In Italy, many ornamental plant species belonging to several botanical families have been found to be infected by phytoplasmas, classified into the ribosomal groups 16SrI, 16SrII, 16SrV and 16SrXII. During a survey carried out in commercial gardens in Rome, some marguerite daisy (Argyranthemum frutescens plants showing symptoms of phytoplasma-like disease, were collected and submitted to molecular analyses. Cloning and sequencing of the portion of the 16S rRNA gene followed by BLAST analysis, real and virtual restriction fragment length polymorphism anlaysis with AluI and RsaI, allowed assignment of the detected phytoplasma to the 16SrIX-C group (Picris echioides yellows, PEY.

  18. 29 CFR 4281.16 - Benefit valuation methods-plans closing out.

    Science.gov (United States)

    2010-07-01

    ..., as determined under this subpart. (b) Valuation rule. The present value of nonforfeitable benefits... 4281(b) of ERISA, the plan sponsor shall value the plan's benefits in accordance with paragraph (b) of... 29 Labor 9 2010-07-01 2010-07-01 false Benefit valuation methods-plans closing out. 4281.16...

  19. FY16-20 Strategic Plan.

    Energy Technology Data Exchange (ETDEWEB)

    Harwell, Amber Suzanne [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

    2015-07-01

    Welcome to our FY16–FY20 Strategic Plan, which both refects our continued dedication to the work we do and reinforces the importance of the integrated Laboratories’ strategic framework to our future. This document is the result of the leadership team’s journey over the past few years in response to the needs of our nation. In an external environment that continues to change, sometimes in unexpected ways, it is critical that our mission areas and our foundation become increasingly synergistic, forming a whole whose parts are interdependent.

  20. Laser Spectroscopy Monitoring of 13C18O16O and 12C17O16O of Atmospheric Carbon Dioxide

    Science.gov (United States)

    Shorter, J. H.; Nelson, D. D.; Ono, S.; McManus, J. B.; Zahniser, M. S.

    2017-12-01

    One of the main challenges to making accurate predictions of future changes in CO2 concentration is the capability to determine what fraction of human produced CO2 remains in the atmosphere. We present our progress in the application of Tunable Infrared Laser Direct Absorption Spectroscopy (TILDAS) to the measurement of the primary clumped (13C18O16O) as well as 17O (12C17O16O) isotopologues of atmospheric CO2, as a tracer of its sources and sinks. We expect unique isotopologue signals in CO2 from high-temperature combustion sources, plants, soils, and air-sea exchange processes. High sampling frequency (a few minutes for each sample vs. reference cycle) achieved by a TILDAS instrument is expected to enable us to document local heterogeneous sources and temporal variations. The TILDAS is equipped with a newly developed 400-meter absorption cell. We designed a dual pressure measurement technique in which the clumped isotopologue, 13C18O16O, and 13C16O16O are first measured at 30 torr cell pressure. This is followed by measurement of 12C17O16O, 12C18O16O and 12C16O16O at lower ( 5 torr) cell pressure. Isotopologue ratios are compared between reference and sample gases. Preliminary tests demonstrated a precision approaching 0.03 ‰ for the ratio 13C18O16O/13C16O16O and 0.08‰ for Δ13C18O16O value (1σ repeatability for 4 min sample vs. reference cycle). Sample size for a single analysis is approximately 100 mL of air (1.6μmol of CO2). Given the previously observed range of variations for Δ13C18O16O and Δ17O values as large as 0.6 to 0.3 ‰, respectively, TILDAS offers a novel approach for real time monitoring of atmospheric CO2 isotopologues. It was found that achieving better than 0.1‰ requires careful matching of CO2 mixing ratios between reference and sample air. A primary cause of pressure and mixing ratio dependence is inaccurate baseline fitting (analogous to abundance sensitivity or pressure baseline for IRMS). Given that mixing ratios of atmospheric

  1. 105-C Facility characterization plan

    International Nuclear Information System (INIS)

    Miller, R.L.

    1997-01-01

    This facility characterization plan is a site-specific document that describes how quantification and qualification of the radiological sources and the radioactive contamination in the 105-C Building will be accomplished. Characterization of hazardous materials will be addressed in a separate plan. This plan was developed from review of video tapes, photographs, and records. The purpose of this characterization plan is to provide an efficient and cost-effective method for determining the distribution of radioactive contamination at the 105-C Facility

  2. 16 CFR 1000.19 - Office of Financial Management, Planning and Evaluation.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Office of Financial Management, Planning and... COMMISSION ORGANIZATION AND FUNCTIONS § 1000.19 Office of Financial Management, Planning and Evaluation. The Office of Financial Management, Planning and Evaluation is responsible for developing the Commission's...

  3. 7 CFR 407.17 - Group risk plan for wheat.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Group risk plan for wheat. 407.17 Section 407.17..., DEPARTMENT OF AGRICULTURE GROUP RISK PLAN OF INSURANCE REGULATIONS § 407.17 Group risk plan for wheat. The provisions of the Group Risk Plan for Wheat for the 2000 and succeeding crop years are as follows: 1...

  4. 7 CFR 407.11 - Group risk plan for corn.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Group risk plan for corn. 407.11 Section 407.11..., DEPARTMENT OF AGRICULTURE GROUP RISK PLAN OF INSURANCE REGULATIONS § 407.11 Group risk plan for corn. The provisions of the Group Risk Plan for Corn for the 2000 and succeeding crop years are as follows: 1...

  5. Arabidopsis ketoacyl-CoA synthase 16 (KCS16) forms C36 /C38 acyl precursors for leaf trichome and pavement surface wax.

    Science.gov (United States)

    Hegebarth, Daniela; Buschhaus, Christopher; Joubès, Jérôme; Thoraval, Didier; Bird, David; Jetter, Reinhard

    2017-09-01

    The aliphatic waxes sealing plant surfaces against environmental stress are generated by fatty acid elongase complexes, each containing a β-ketoacyl-CoA synthase (KCS) enzyme that catalyses a crucial condensation forming a new C─C bond to extend the carbon backbone. The relatively high abundance of C 35 and C 37 alkanes derived from C 36 and C 38 acyl-CoAs in Arabidopsis leaf trichomes (relative to other epidermis cells) suggests differences in the elongation machineries of different epidermis cell types, possibly involving KCS16, a condensing enzyme expressed preferentially in trichomes. Here, KCS16 was found expressed primarily in Arabidopsis rosette leaves, flowers and siliques, and the corresponding protein was localized to the endoplasmic reticulum. The cuticular waxes on young leaves and isolated leaf trichomes of ksc16 loss-of-function mutants were depleted of C 35 and C 37 alkanes and alkenes, whereas expression of Arabidopsis KCS16 in yeast and ectopic overexpression in Arabidopsis resulted in accumulation of C 36 and C 38 fatty acid products. Taken together, our results show that KCS16 is the sole enzyme catalysing the elongation of C 34 to C 38 acyl-CoAs in Arabidopsis leaf trichomes and that it contributes to the formation of extra-long compounds in adjacent pavement cells. © 2017 John Wiley & Sons Ltd.

  6. Catharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues

    Science.gov (United States)

    Tam, Annie; Gotoh, Hiroaki; Robertson, William M.; Boger, Dale L.

    2010-01-01

    The examination of the catharanthine C16 substituent effects on the Fe(III)-promoted biomimetic coupling reaction with vindoline is detailed, confirming the importance of the presence of a C16 electron-withdrawing substituent, and establishing an unanticipated unique role (>10-fold) that the C16 methyl ester plays in the expression of the natural product properties. Thus, replacement of the vinblastine C16′ methyl ester with an ethyl ester (10-fold), a cyano group (100-fold), an aldehyde (100-fold), a hydroxymethyl group (1000-fold), or a primary carboxamide (>1000-fold) led to surprisingly large reductions in cytotoxic activity. PMID:20932748

  7. Efficacy of low-calorie, partial meal replacement diet plans on weight and abdominal fat in obese subjects with metabolic syndrome: a double-blind, randomised controlled trial of two diet plans - one high in protein and one nutritionally balanced.

    Science.gov (United States)

    Lee, K; Lee, J; Bae, W K; Choi, J K; Kim, H J; Cho, B

    2009-02-01

    Little is known about the relative efficacy of high-protein vs. conventional diet plans that include partial meal replacements on body fat loss in obese subjects with metabolic syndrome. We aimed to evaluate the efficacy of two low-calorie diets with partial meal replacement plans-a high-protein plan (HP) and a nutritionally balanced conventional (C) plan-on reducing obesity in obese subjects with metabolic syndrome. In a 12-week, double-blind study, we randomised 75 participants to either the HP- or the C-plan group. We recorded key metrics at 0 and 12 weeks. The overall mean weight loss was 5 kg in the HP-plan group and 4.9 kg in the C-plan group (p = 0.72). Truncal fat mass decreased 1.6 kg in the HP-plan group (p or = 70% dietary compliance, however, truncal and whole body fat mass decreased more in the HP-plan group (Delta 2.2 kg and Delta 3.5 kg respectively) than in the C-plan group (Delta 1.3 kg and Delta 2.3 [corrected] kg respectively) (p < 0.05). The HP- and C-plans had a similar effect on weight and abdominal fat reduction, but the HP-plan was more effective in reducing body fat among compliant subjects.

  8. Structure in the 12C+ 12C and 8Be+16O fission width distribution of 24Mg observed via the reaction 12C(16O,α)24Mg(→X+Y)

    International Nuclear Information System (INIS)

    Lazzarini, A.J.; Steadman, S.G.; Ledoux, R.J.; Sperduto, A.; Young, G.R.; Van Bibber, K.; Cosman, E.R.

    1983-01-01

    Prominent gross and intermediate width structures are observed in the 12 C+ 12 C, 12 C+ 12 C((2 + ), 1 C((2 + )+ 12 C((2 + ), 8 Be+ 16 O, and 8 Be+ 16 O + (3 - , O + ) decay channels following 24 Mg* population via the 12 C( 16 O,α) 24 Mg reaction at E/sub c.m./ = 33 MeV. Evidence that the 12 C( 16 O,α) 24 Mg reaction populates states in 24 Mg which are associated with 12 C+ 12 C resonances is presented in the form of correlation analyses between the α+ 12 C+ 12 C three-body spectra and previously measured 12 C+ 12 C elastic and inelastic excitation functions. Direct determination of 12 C+ 12 C widths from these measurements is obscured by a background of other strong transitions which appear to be present in the 12 C( 16 O,α) 24 Mg singles spectrum

  9. Investigation of low spin resonances in the 12C+12C and 16O+12C systems

    International Nuclear Information System (INIS)

    Uzureau, J.L.; Fieni, J.M.; Cocu, F.; Michaudon, A.

    1979-01-01

    The excitation functions of the 12 C( 12 C,α) 20 Ne and 12 C( 16 O,α) 24 Mg reactions were measured at different angles below the Coulomb barrier. Resonant structures were found at Esub(cm)=5.80 MeV in the 12 C+ 12 C system and at Esub(cm)=6.10 MeV in the 16 O+ 12 C system. From the analysis of angular distributions measured at the previous resonant energies, values of respectively Jsup(π)=0 + and 2 + have been deduced [fr

  10. Plasma C16-Cer levels are increased in patients with preterm labor.

    Science.gov (United States)

    Laudanski, Piotr; Charkiewicz, Karol; Kisielewski, Rafal; Kuc, Pawel; Koc-Zorawska, Ewa; Raba, Grzegorz; Kraczkowski, Janusz; Dymicka-Piekarska, Violetta; Chabowski, Adrian; Kacerovsky, Marian; Jacobsson, Bo; Zabielski, Piotr; Blachnio-Zabielska, Agnieszka

    2016-03-01

    The pathogenesis of preterm labor is fragmentarily explained. The most widely accepted theory points out to infection and inflammation as possible causes, which can be mediated by potentially different factors, including sphingolipid mediators. Sphingolipids are a class of lipids that have been shown as important mediators in various cell processes such as: proliferation, growth, apoptosis, stress response, necrosis and inflammation. The aim of the study was to assess plasma concentrations of selected sphingolipids in patients with preterm labor. We used ultra-high performance liquid chromatography with triple mass spectrometry (UHPLC-ESI-MS/MS) to assess plasma concentrations of the 11 sphingolipids in patients presenting with symptoms of preterm labor (n=61) and threatened preterm labor (n=40). We observed a statistically significant increase (p-valueCer in patients with preterm labor as compared to the control group. We also found C16-Cer to be the best predictor of preterm labor in the group of patients with symptoms occurring after 32 weeks of gestation. Our findings show a possible involvement of selected sphingolipids, especially C16-Cer, in the pathogenesis of preterm labor. Their role as predictors of preterm delivery needs to be validated in the future on larger group of patients. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Vaporization, fusion and sublimation enthalpies of the dicarboxylic acids from C4 to C14 and C16

    International Nuclear Information System (INIS)

    Roux, Maria Victoria; Temprado, Manuel; Chickos, James S.

    2005-01-01

    The fusion enthalpies of the series butanedioic acid through to tetradecanedioic acid and hexadecanedioic acids have been measured by DSC. In addition to fusion, a number of solid-solid phase transitions have also been detected in these diacids. The vaporization enthalpies of these compounds have been measured by correlation gas chromatography using the vaporization enthalpies of butanedioic, hexanedioic and decanedioic acids as standards. The vaporization enthalpies of the diacids from C 4 to C 10 correlated linearly with the number of methylene groups present. Above C 10 , the vaporization enthalpies of C 11 -C 14 and C 16 begin to deviate from linearity. The vaporization enthalpies for these compounds are dependent on the temperature of the GC column used. Similar departure from linearity has also been observed previously in the sublimation enthalpies for these compounds. The results are discussed in terms of formation of a cyclic intramolecular hydrogen bonded network in the gas phase similar to the bimolecular association observed in smaller mono-carboxylic acids at ambient temperatures

  12. Drunk Driving. Surgeon General's Workshop. Proceedings (Washington, D.C., December 14-16, 1988).

    Science.gov (United States)

    Janus Associates.

    This volume presents solutions, recommendations, and strategies in eleven interrelated areas considered at the Surgeon General's Workshop on Drunk Driving held in Washington, D.C. in December of 1988. Lists of the members of the Workshop Planning Committee and members of the federal advisory group on follow-up activities for the workshop are…

  13. Sampling plan to support HLW tank 16

    International Nuclear Information System (INIS)

    Rodwell, P.O.; Martin, B.

    1997-01-01

    Plans are to remove the residual waste from the annulus of High-Level Waste Tank 16, located in the H-Area Tank Farm, in 1998. The interior of the tank is virtually clean. In the late 1970's, the waste was removed from the interior of the tank by several campaigns of waste removal with slurry pumps, spray washing, and oxalic acid cleaning. The annulus of the tank at one time had several thousand gallons of waste salt, which had leaked from the tank interior. Some of this salt was removed by adding water to the annulus and circulating, but much of the salt remains in the annulus. In order to confirm the source term used for fate and transport modeling, samples of the tank interior and annulus will be obtained and analyzed. If the results of the analyses indicate that the data used for the initial modeling is bounding then no changes will be made to the model. However, if the results indicate that the source term is higher than that assumed in the initial modeling, thus not bounding, additional modeling will be performed. The purpose of this Plan is to outline the approach to sampling the annulus and interior of Tank 16 as a prerequisite to salt removal in the annulus and closure of the entire tank system. The sampling and analysis of this tank system must be robust to reasonably ensure the actual tank residual is within the bounds of analysis error

  14. IAEA INTOR workshop report, group 16

    International Nuclear Information System (INIS)

    Hiraoka, Toru; Suzuki, Yasuo; Ogata, Atsushi

    1979-10-01

    This is the contribution of JAERI team to Group 16 of IAEA INTOR Workshop, which discusses diagnostics, data acquisition and control. Data assessment is made to consider diagnostics of INTOR. Also considered is how the diagnostics, data acquisition and control should be for a tokamak of the coming generation. The pending problems set at the Session 2 as hometasks are studied, which are given in Appendix. (author)

  15. Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11

    Directory of Open Access Journals (Sweden)

    Hamed I. Ali

    2011-01-01

    Full Text Available We investigated the 16α-hydroxylation of steroid molecules and regioselective binding mode in homology-modeled cytochrome P450-2C11 to correlate the biological study with the computational molecular modeling. It revealed that there was a positive relationship between the observed inhibitory potencies and the binding free energies. Docking of steroid molecules into this homology-modeled CYP2C11 indicated that 16α-hydroxylation is favored with steroidal molecules possessing the following components, (1 a bent A-B ring configuration (5β-reduced, (2 C-3 α-hydroxyl group, (3 C-17β-acetyl group, and (4 methyl group at both the C-18 and C-19. These respective steroid components requirements were defined as the inhibitory contribution factor. Overall studies of the male rat CYP2C11 metabolism revealed that the above-mentioned steroid components requirements were essential to induce an effective inhibition of [3H]progesterone 16α-hydroxylation. As far as docking of homology-modeled CYP2C11 against investigated steroids is concerned, they are docked at the active site superimposed with flurbiprofen. It was also found that the distance between heme iron and C16α-H was between 4 to 6 Å and that the related angle was in the range of 180±45∘.

  16. The International Space Life Sciences Strategic Planning Working Group

    Science.gov (United States)

    White, Ronald J.; Rabin, Robert; Lujan, Barbara F.

    1993-01-01

    Throughout the 1980s, ESA and the space agencies of Canada, Germany, France, Japan, and the U.S. have pursued cooperative projects bilaterally and multilaterally to prepare for, and to respond to, opportunities in space life sciences research previously unapproachable in scale and sophistication. To cope effectively with likely future space research opportunities, broad, multilateral, coordinated strategic planning is required. Thus, life scientists from these agencies have allied to form the International Space Life Sciences Strategic Planning Working Group. This Group is formally organized under a charter that specifies the purpose of the Working Group as the development of an international strategic plan for the space life sciences, with periodic revisions as needed to keep the plan current. The plan will be policy-, not operations-oriented. The Working Group also may establish specific implementation teams to coordinate multilateral science policy in specific areas; such teams have been established for space station utilization, and for sharing of flight equipment.

  17. 42 CFR 51c.105 - Accord with health planning.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Accord with health planning. 51c.105 Section 51c... COMMUNITY HEALTH SERVICES General Provisions § 51c.105 Accord with health planning. A grant may be made... approval by the appropriate health planning agencies have been met. ...

  18. Observation/confirmation of hindered E2 strength in {sup 18}C/{sup 16}C

    Energy Technology Data Exchange (ETDEWEB)

    Ong, H.J. [Osaka University, RCNP, Ibaraki, Osaka (Japan); Imai, N. [KEK, Tsukuba, Ibaraki (Japan); Suzuki, D.; Iwasaki, H.; Onishi, T.K.; Suzuki, M.K.; Nakao, T.; Ichikawa, Y. [University of Tokyo, Department of Physics, Bunkyo,Tokyo (Japan); Sakurai, H.; Takeuchi, S.; Kondo, Y.; Aoi, N.; Baba, H.; Bishop, S.; Ishihara, M.; Kubo, T.; Motobayashi, T.; Yanagisawa, Y. [RIKEN, RIKEN Nishina Center, Wako, Saitama (Japan); Ota, S. [University of Tokyo, RIKEN Campus, CNS, Wako, Saitama (Japan); Togano, Y.; Kurita, K. [Rikkyo University, Department of Physics, Toshima, Tokyo (Japan); Nakamura, T.; Okumura, T. [Tokyo Institute of Technology, Department of Physics, Meguro, Tokyo (Japan)

    2009-12-15

    We have measured the lifetime of the first excited 2{sup +} state in {sup 18}C using an upgraded recoil shadow method to determine the electric quadrupole transition. The measured mean lifetime is 18.9{+-}0.9 (stat){+-}4.4 (syst) ps, corresponding to B(E2;2{sub 1} {sup +}{yields} 0{sup +} {sub gs}) = 4.3{+-}0.2{+-}1.0 e{sup 2}fm{sup 4}, or about 1.5 Weisskopf units. The mean lifetime of the first 2{sup +} state in {sup 16}C was remeasured to be 18.3{+-}1.4{+-}4.8 ps, about four times shorter than the value reported previously. The discrepancy is explained by incorporating the {gamma} -ray angular distribution obtained in this work into the previous measurement. The observed transition strengths in {sup 16,18}C are hindered compared to the empirical values, indicating that the anomalous E2 strength observed in {sup 16}C persists in {sup 18}C. (orig.)

  19. A psychometric evaluation of the clinician-rated Quick Inventory of Depressive Symptomatology (QIDS-C16) in patients with bipolar disorder.

    Science.gov (United States)

    Bernstein, Ira H; Rush, A John; Suppes, Trisha; Trivedi, Madhukar H; Woo, Ada; Kyutoku, Yasushi; Crismon, M Lynn; Dennehy, Ellen; Carmody, Thomas J

    2009-06-01

    The clinician-rated, 16-item Quick Inventory of Depressive Symptomatology (QIDS-C16) has been extensively evaluated in patients with major depressive disorder (MDD). This report assesses the psychometric properties of the QIDS-C16 in outpatients with bipolar disorder (BD, N = 405) and MDD (N = 547) and in bipolar patients in the depressed phase only (BD-D) (N = 99) enrolled in the Texas Medication Algorithm Project (TMAP) using classical test theory (CTT) and the Samejima graded item response theory (IRT) model. Values of coefficient alpha were very similar in BD, MDD, and BD-D groups at baseline (alpha = 0.80-0.81) and at exit (alpha = 0.82-0.85). The QIDS-C16 was unidimensional for all three groups. MDD and BD-D patients (n = 99) had comparable symptom levels. The BD-D patients (n = 99) had the most, and bipolar patients in the manic phase had the least depressive symptoms at baseline. IRT analyses indicated that the QIDS-C16 was most sensitive to the measurement of depression for both MDD patients and for BD-D patients in the average range. The QIDS-C16 is suitable for use with patients with BD and can be used as an outcome measure in trials enrolling both BD and MDD patients. John Wiley & Sons, Ltd

  20. Sub-Coulomb α Transfers on C12 and the C12(α, γ)O16 S Factor

    International Nuclear Information System (INIS)

    Brune, C. R.; Geist, W. H.; Kavanagh, R. W.; Veal, K. D.

    1999-01-01

    The 12 C( α, γ) 16 O reaction is crucial for the understanding of He burning in massive stars, but the low-energy cross section is highly uncertain. To address this problem we have measured at sub-Coulomb energies total cross sections for the 12 C( 6 Li, d) 16 O and 12 C( 7 Li, t) 16 O reactions to the bound 2 + and 1 - states of 16 O . The data are analyzed to obtain the reduced α widths of these states. Together with capture and phase-shift data, these results provide for a more accurate determination of the low-energy 12C(α, γ) 16 O S factor: S E1 (0.3 MeV) =101±17 keV b and S E2 (0.3 MeV) =42 +16 -23 keV b for the E1 and E2 multipole components of the reaction. (c) 1999 The American Physical Society

  1. THE STRATEGIC PLANNING OF IS/IT AT PT. LINTAS GROUP

    Directory of Open Access Journals (Sweden)

    Hendra Maya Topani

    2011-10-01

    Full Text Available The purpose of this study is to find the requirement of Information Systems and Information Technology (IS/IT in the development of the construction of Base Transceiver Station tower (BTS. The methodology that is used is the method of Ward and Peppard. The relevant data were extracted from interviews with the management. Questionnaires were distributed to 16 respondents, and observation was made accordingly. The results of this study are in the form of the application portfolio recommendation, proposal of the IT Division enhancement and the action time of IS/IT. The planning of IS/IT is as a guiding framework for the development of future changes at PT. Lintas Group.Keywords: Information System, Technology Information, application portfolio, telecommunication.

  2. Folding model analyses of 12C-12C and 16O-16O elastic scattering using the density-dependent LOCV-averaged effective interaction

    Science.gov (United States)

    Rahmat, M.; Modarres, M.

    2018-03-01

    The averaged effective two-body interaction (AEI), which can be generated through the lowest order constrained variational (LOCV) method for symmetric nuclear matter (SNM) with the input [Reid68, Ann. Phys. 50, 411 (1968), 10.1016/0003-4916(68)90126-7] nucleon-nucleon potential, is used as the effective nucleon-nucleon potential in the folding model to describe the heavy-ion (HI) elastic scattering cross sections. The elastic scattering cross sections of 12C-12C and 16O-16O systems are calculated in the above framework. The results are compared with the corresponding calculations coming from the fitting procedures with the input finite range D D M 3 Y 1 -Reid potential and the available experimental data at different incident energies. It is shown that a reasonable description of the elastic 12C-12C and 16O-16O scattering data at the low and medium energies can be obtained by using the above LOCV AEI, without any need to define a parametrized density-dependent function in the effective nucleon-nucleon potential, which is formally considered in the typical D D M 3 Y 1 -Reid interactions.

  3. Total reaction cross section and foward glory for 12C + 16O

    International Nuclear Information System (INIS)

    Villari, A.C.C.; Lepine-Szily, A.; Lichtenthaler Filho, R.; Portezan Filho, O.; Obuti, M.M.

    1988-12-01

    A model-independent method is proposed for the determination of the total reaction cross section from elastic angular distributions. This method based on the generalized optical theorem, was applied to 16 complete elastic angular distributions of the system 12 C + 16 O at energies between E CM =8.55 MeV and E CM = 26.74 MeV. Some of the angular distributions were measured at the Sao Paulo Pelletron Laboratory. Angular distributions measured by the Erlangen and Saclay groups were also used. The reaction cross section is compared with fusion measurements and with σ R obtained by indirect methods. The existence and conditions for the observation of the nuclear forward glory scattering are investigated. (author) [pt

  4. Dealer Group or Financial Planning Group? A Brief Technical Note

    Directory of Open Access Journals (Sweden)

    Lujer Santacruz

    2011-06-01

    Full Text Available This technical note examines whether the industry practice of using the term dealer group when referring to afinancial planning group contributes to the general perception that financial advisers are not objective whenmaking financial product recommendations. An experimental design carried out through an online survey isused. This is supplemented by a direct comparison survey on the two terminologies. The results provide acase for the industry to adopt a new terminology.

  5. 38 CFR 8.16 - Conversion of a 5-year level premium term policy as provided for under § 1904 of title 38 U.S.C.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Conversion of a 5-year level premium term policy as provided for under § 1904 of title 38 U.S.C. 8.16 Section 8.16 Pensions... Plan § 8.16 Conversion of a 5-year level premium term policy as provided for under § 1904 of title 38 U...

  6. Spectroscopic study of nuclei of the 1f-2p layer by means of (16O,14C) and (16O,12C) transfer reactions

    International Nuclear Information System (INIS)

    Mallet-Lemaire, M.C.

    1973-01-01

    One-and two-nucleon transfer reactions induced by light projectiles have long been established as powerful spectroscopic tools to test one-and two-nucleon configurations of the wave functions describing the excited states of the residual nucleus A comparatively to the target nuclei A-1 and A-2. As soon as heavy ion beams became available, a further step was made in the experimental study of few-nucleon configurations by increasing the number of transferred particles as well as the variety of reactions leading to the same residual nucleus. It is well known that many theoretical models emphasize the role played by four-nucleon correlations in the microscopic description of deformed states. An experimental study of the reaction mechanism for ( 16 0, 12 C) and ( 16 0, 14 C) has been carried out by measuring angular distributions at several incident energies and excitation functions. A semi-classical description of the experimental results shows the strong influence of nuclear distortions on multi-nucleon-transfer reactions which appear with increasing incident energies. It will be noticed that spectroscopic information concerning the transferred nucleons can be achieved only through a complete finite range DWBA calculation including a microscopic nuclear structure form factor. The relative influence of the kinematic factors and nuclear structure factors on the DWBA cross-sections has been also investigated. The preliminary results on the DWBA analysis of the 54 Fe( 16 0, 12 C) 58 Ni and 48 Ca( 16 O, 14 C) 50 Ti angular distributions are discussed. Finally, ( 16 0, 14 C) and ( 16 0, 12 C) transfer reactions on different 1f-2p shell targets are described

  7. Photodissociation of pyrene cations: structure and energetics from C16H10(+) to C14(+) and almost everything in between.

    Science.gov (United States)

    West, Brandi; Useli-Bacchitta, Francesca; Sabbah, Hassan; Blanchet, Valérie; Bodi, Andras; Mayer, Paul M; Joblin, Christine

    2014-09-11

    The unimolecular dissociation of the pyrene radical cation, C16H10(+•), has been explored using a combination of computational techniques and experimental approaches, such as multiple photon absorption in the cold ion trap Piège à Ions pour la Recherche et l'Etude de Nouvelles Espèces Astrochimiques (PIRENEA) and imaging photoelectron photoion coincidence spectrometry (iPEPICO). In total, 22 reactions, involving the fragmentation cascade (H, C2H2, and C4H2 loss) from the pyrene radical cation down to the C14(+•) fragment ion, have been studied using PIRENEA. Branching ratios have been measured for reactions from C16H10(+•), C16H8(+•), and C16H5(+). Density functional theory calculations of the fragmentation pathways observed experimentally and postulated theoretically lead to 17 unique structures. One important prediction is the opening of the pyrene ring system starting from the C16H4(+•) radical. In the iPEPICO experiments, only two reactions could be studied, namely, R1 C16H10(+•) → C16H9(+) + H (m/z = 201) and R2 C16H9(+) → C16H8(+•) + H (m/z = 200). The activation energies for these reactions were determined to be 5.4 ± 1.2 and 3.3 ± 1.1 eV, respectively.

  8. Interim Status Closure Plan Open Burning Treatment Unit Technical Area 16-399 Burn Tray

    Energy Technology Data Exchange (ETDEWEB)

    Vigil-Holterman, Luciana R. [Los Alamos National Laboratory

    2012-05-07

    This closure plan describes the activities necessary to close one of the interim status hazardous waste open burning treatment units at Technical Area (TA) 16 at the Los Alamos National Laboratory (LANL or the Facility), hereinafter referred to as the 'TA-16-399 Burn Tray' or 'the unit'. The information provided in this closure plan addresses the closure requirements specified in the Code of Federal Regulations (CFR), Title 40, Part 265, Subparts G and P for the thermal treatment units operated at the Facility under the Resource Conservation and Recovery Act (RCRA) and the New Mexico Hazardous Waste Act. Closure of the open burning treatment unit will be completed in accordance with Section 4.1 of this closure plan.

  9. Minimum variance and variance of outgoing quality limit MDS-1(c1, c2) plans

    Science.gov (United States)

    Raju, C.; Vidya, R.

    2016-06-01

    In this article, the outgoing quality (OQ) and total inspection (TI) of multiple deferred state sampling plans MDS-1(c1,c2) are studied. It is assumed that the inspection is rejection rectification. Procedures for designing MDS-1(c1,c2) sampling plans with minimum variance of OQ and TI are developed. A procedure for obtaining a plan for a designated upper limit for the variance of the OQ (VOQL) is outlined.

  10. Digital Instrumentation and Control working group (DICWG) - MDEP DICWG Programme Plan 2012 2013

    International Nuclear Information System (INIS)

    2012-02-01

    The Multinational Design Evaluation Programme (MDEP) Digital Instrumentation and Controls Working Group (DICWG) was approved by MDEP's Policy Group in March 2008 and meets approximately 3 times a year. All MDEP members and the IAEA are invited to participate in this working group's activities. The DICWG's main objectives are as follows: - to document common positions in the DI and C safety systems design areas; - to harmonise and converge national codes, standards and regulatory requirements and practices in this area while recognising the sovereign rights and responsibilities of national regulators in carrying out their safety reviews of new reactor designs (see the DICWG programme plan for more details of the group's work). The DICWG interacts regularly with the following organisations: - IEC (International Electro-technical Commission) Subcommittee 45A, Instrumentation and Control of Nuclear Facilities; - IEEE (Institute of Electric and Electronics Engineers); - other organisations involved in the design of digital I and C safety systems for nuclear power plants. The DICWG reports its status to the MDEP Steering Technical Committee at the latter's thrice annual meetings. This document presents the 2012 and 2013 programme plan and its products: the Generic Common Position DICWG-02 on Software Tools; the Generic Common Position DICWG-03 on Verification and Validation throughout the Life Cycle of Safety Systems Using Digital Computers; the Generic Common Position DICWG-04 on Communication Independence; the Generic Common Position DICWG-05 on Treatment of Hardware Description Language (HDL) Programmed Devices for Use in Nuclear Safety Systems; the Generic Common Position DICWG-06 on Simplicity in Design; the Generic Common Position DICWG-08 on Impact of Cyber Security Features on Digital I and C Safety Systems

  11. 40 CFR 60.55c - Waste management plan.

    Science.gov (United States)

    2010-07-01

    ... management plan shall identify both the feasibility and the approach to separate certain components of solid... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Waste management plan. 60.55c Section 60.55c Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED...

  12. Effect of alpha states in the 16O+12C scattering and in the 12C +α → 16O capture reaction of astrophysical interest

    International Nuclear Information System (INIS)

    Morais, M.C.; Lichtenthaele, R.; Arazi, A.; Hojman, D.; Cardona, M.A.; Fimiani, L.; Carnelli, P.F.; Marti, G.V.; Pacheco, A.J.; Martinez Heimann, D.; Negri, A.E.; Capurro, O.A.; Niello, Fernandez; Montero, P.

    2011-01-01

    Full text: The 16 O+ 12 C elastic scattering was investigated considering the effect of exchange of an alpha particle between projectile and target leading to the same nuclei of the entrance channel (elastic transfer). Angular distributions were analyzed in an energy range from 8.55 MeV to 56.57 MeV in the center of mass frame. The Coulomb barrier is around 11MeV for this system. Measurements of angular distributions of elastic and inelastic transfer reactions to states of the 16 O in the 16 O+ 12 C system were performed at the TANDAR Laboratory in Buenos Aires, using an 16 O beam of E lab = 46; 26 MeV. The transfer angular distributions were analyzed by DWBA using the computer code FRESCO. Those measurements provided the spectroscopic factors of 12 C + α → 16 O for the ground state and for J π = 2 + and J π = 1 - 16 O excited states, both just below the α-threshold at 7.16 MeV. The Asymptotic Normalization Coefficient (ANC) for the J π = 2 + state was obtained (1.05 ±0,13(10 5 fm -1/2 )) and used to calculate the reduced width of this state, with this value a R-matrix calculation was performed to determine the astrophysical S-factor in energies around the Gamow peak, S(E2)=37keVb. (author)

  13. 18 CFR 141.51 - FERC Form No. 714, Annual Electric Balancing Authority Area and Planning Area Report.

    Science.gov (United States)

    2010-04-01

    ..., Annual Electric Balancing Authority Area and Planning Area Report. 141.51 Section 141.51 Conservation of...) § 141.51 FERC Form No. 714, Annual Electric Balancing Authority Area and Planning Area Report. (a) Who... Policies Act, 16 U.S.C. 2602, operating a balancing authority area, and any group of electric utilities...

  14. Histiocitose das células de Langerhans: experiência de 16 anos Langerhans cell histiocytosis: a 16-year experience

    Directory of Open Access Journals (Sweden)

    Márcia Kanadani Campos

    2007-02-01

    Full Text Available OBJETIVOS: Descrever a apresentação clínica da histiocitose das células de Langerhans e comparar sua evolução de acordo com a idade, estadiamento e resposta ao tratamento. MÉTODOS: Análise retrospectiva dos dados referentes a 33 crianças com histiocitose das células de Langerhans acompanhadas no Hospital das Clínicas da Universidade Federal de Minas Gerais no período de 1988 a 2004. RESULTADOS: A idade ao diagnóstico variou de 2 meses a 16 anos (mediana: 2,5 anos. Dezessete crianças eram do sexo masculino. O tempo de seguimento variou de 21 dias a 16,2 anos (mediana: 3,4 anos. As manifestações clínicas mais comuns ao diagnóstico foram lesões osteolíticas, linfadenomegalia e lesões cutâneas. A sobrevida global para todo o grupo foi de 86,1% aos 16 anos (IC95% 66,6-94,6. Os óbitos ocorreram em pacientes com doença multissistêmica e disfunção orgânica ao diagnóstico. Os pacientes que apresentaram resposta "melhor" à sexta semana de tratamento apresentaram uma probabilidade estimada de sobrevida global significativamente maior em relação aos que apresentaram progressão da doença. A sobrevida global foi significativamente maior para os pacientes com doença em um único sistema. A probabilidade de sobrevida livre de eventos para todo o grupo foi de 30,9% aos 16 anos (IC95% 15,6-47,5, sendo significativamente maior para os portadores de doença em um único sistema. A idade não se associou com a sobrevida livre de eventos. A seqüela mais comum foi o diabetes insipidus. Não foram observados casos de neoplasias secundárias. CONCLUSÃO: A histiocitose das células de Langerhans apresenta uma grande variedade de manifestações clínicas, com alta taxa de recidivas e baixa taxa de mortalidade.OBJECTIVES: To describe the clinical course of Langerhans cell histiocytosis and to compare its outcome according to age, staging of the disease and treatment response. METHODS: Retrospective analysis of data on 33 children with

  15. Structuring group medical practices: tax planning aspects.

    Science.gov (United States)

    Gassman, A S; Conetta, T F

    1992-01-01

    This article is the first in a series addressing the structuring of group medical practice entities, shareholder relationships, and general representation factors. In this article, a general background in federal tax planning is provided, including strategies for minimization of income tax payment and the potential problems that may be encountered when a group practice is not carefully structured.

  16. Atmospheric histories and growth trends of C4F10, C5F12, C6F14, C7F16 and C8F18

    Directory of Open Access Journals (Sweden)

    R. F. Weiss

    2012-05-01

    Full Text Available Atmospheric observations and trends are presented for the high molecular weight perfluorocarbons (PFCs: decafluorobutane (C4F10, dodecafluoropentane (C5F12, tetradecafluorohexane (C6F14, hexadecafluoroheptane (C7F16 and octadecafluorooctane (C8F18. Their atmospheric histories are based on measurements of 36 Northern Hemisphere and 46 Southern Hemisphere archived air samples collected between 1973 to 2011 using the Advanced Global Atmospheric Gases Experiment (AGAGE "Medusa" preconcentration gas chromatography-mass spectrometry systems. A new calibration scale was prepared for each PFC, with estimated accuracies of 6.8% for C4F10, 7.8% for C5F12, 4.0% for C6F14, 6.6% for C7F16 and 7.9% for C8F18. Based on our observations the 2011 globally averaged dry air mole fractions of these heavy PFCs are: 0.17 parts-per-trillion (ppt, i.e., parts per 1012 for C4F10, 0.12 ppt for C5F12, 0.27 ppt for C6F14, 0.12 ppt for C7F16 and 0.09 ppt for C8F18. These atmospheric mole fractions combine to contribute to a global average radiative forcing of 0.35 mW m−2, which is 6% of the total anthropogenic PFC radiative forcing (Montzka and Reimann, 2011; Oram et al., 2012. The growth rates of the heavy perfluorocarbons were largest in the late 1990s peaking at 6.2 parts per quadrillion (ppq, i.e., parts per 1015 per year (yr for C4F10, at 5.0 ppq yr−1 for C5F12 and 16.6 ppq yr−1 for C6F14 and in the early 1990s for C7F16 at 4.7 ppq yr−1 and in the mid 1990s for C8F18 at 4.8 ppq yr−1. The 2011 globally averaged mean atmospheric growth rates of these PFCs are subsequently lower at 2.2 ppq yr−1 for C4F10, 1.4 ppq yr−1 for C5F12, 5.0 ppq yr−1 for C6F14, 3.4 ppq yr−1 for C7F16 and 0.9 ppq yr−1 for C8F18. The more recent slowdown in the growth rates suggests that emissions are declining as compared to the 1980s and 1990s.

  17. EURLIB-LWR-45/16 and - 15/5. Two board group libraries for LWR-shielding problems

    Energy Technology Data Exchange (ETDEWEB)

    Herrnberger, V

    1982-04-01

    Specifications of the broad group cross section libraries EURLIB-LWR-45/16 and -15/5 are given. They are based on EURLIB-III data and produced for LWR shielding problems. The elements considered are H, C{sub 12}, O, Na, Al, Si, Ca, Cr, Mn, Fe, Ni, Zr, U{sub 235}, U{sub 238}. The cross section libraries are available upon request from EIR, RSIC, NEA-CPL and IAEA-NDS. (author) Refs, figs, tabs

  18. The 16 most common fossil groups from Danian found in Faxe Quarry

    DEFF Research Database (Denmark)

    Lauridsen, Bodil Wesenberg

    2009-01-01

    Twelve folders dealing with the 16 most common fossil groups from Danian found in Faxe Quarry. The folders are for sale at the museum and designated for visitor......Twelve folders dealing with the 16 most common fossil groups from Danian found in Faxe Quarry. The folders are for sale at the museum and designated for visitor...

  19. Group versus individual family planning counseling in Ghana: a randomized, noninferiority trial.

    Science.gov (United States)

    Schwandt, Hilary M; Creanga, Andreea A; Danso, Kwabena A; Adanu, Richard M K; Agbenyega, Tsiri; Hindin, Michelle J

    2013-08-01

    Group, rather than individual, family planning counseling has the potential to increase family planning knowledge and use through more efficient use of limited human resources. A randomized, noninferiority study design was utilized to identify whether group family planning counseling is as effective as individual family planning counseling in Ghana. Female gynecology patients were enrolled from two teaching hospitals in Ghana in June and July 2008. Patients were randomized to receive either group or individual family planning counseling. The primary outcome in this study was change in modern contraceptive method knowledge. Changes in family planning use intention before and after the intervention and intended method type were also explored. Comparisons between the two study arms suggest that randomization was successful. The difference in change in modern contraceptive methods known from baseline to follow-up between the two study arms (group-individual), adjusted for study site, was -0.21, (95% confidence interval: -0.53 to 0.12) suggesting no difference between the two arms. Group family planning counseling was as effective as individual family planning counseling in increasing modern contraceptive knowledge among female gynecology patients in Ghana. Copyright © 2013 Elsevier Inc. All rights reserved.

  20. Group Acceptance Sampling Plan for Lifetime Data Using Generalized Pareto Distribution

    Directory of Open Access Journals (Sweden)

    Muhammad Aslam

    2010-02-01

    Full Text Available In this paper, a group acceptance sampling plan (GASP is introduced for the situations when lifetime of the items follows the generalized Pareto distribution. The design parameters such as minimum group size and acceptance number are determined when the consumer’s risk and the test termination time are specified. The proposed sampling plan is compared with the existing sampling plan. It is concluded that the proposed sampling plan performs better than the existing plan in terms of minimum sample size required to reach the same decision.

  1. Partners in flight bird conservation plan for the Upper Great Lakes Plain (Physiographic Area 16)

    Science.gov (United States)

    Knutson, M.G.; Butcher, G.; Fitzgerald, J.; Shieldcastle, J.

    2001-01-01

    1 November 2001. Conservation of bird habitats is a major focus of effort by Partners in Flight, an international coalition of agencies, citizens, and other groups dedicated to 'keeping common birds common'. USGS worked on a planning team to publish a bird conservation plan for the Upper Great Lakes Plain ecoregion (PIF 16), which includes large portions of southern Wisconsin, southern Michigan and parts of Minnesota, Iowa, Illinois, Indiana, and Ohio. The conservation plan outlines specific habitat restoration and bird population objectives for the ecoregion over the next decade. The plan provides a context for on-the-ground conservation implementation by the US Fish and Wildlife Service, the USDA Natural Resources Conservation Service, the US Forest Service, states, and conservation groups. Citation: Knutson, M. G., G. Butcher, J. Fitzgerald, and J. Shieldcastle. 2001. Partners in Flight Bird Conservation Plan for The Upper Great Lakes Plain (Physiographic Area 16). USGS Upper Midwest Environmental Sciences Center in cooperation with Partners in Flight, La Crosse, Wisconsin. Download from website: http://www.blm.gov/wildlife/pifplans.htm. The Upper Great Lakes Plain covers the southern half of Michigan, northwest Ohio, northern Indiana, northern Illinois, southern Wisconsin, and small portions of southwest Minnesota and northwest Iowa. Glacial moraines and dissected plateaus are characteristic of the topography. Broadleaf forests, oak savannahs, and a variety of prairie communities are the natural vegetation types. A oDriftless Areao was not glaciated during the late Pleistocene and emerged as a unique area of great biological diversity. Priority bird species for the area include the Henslow's Sparrow, Sedge Wren, Bobolink, Golden-winged Warbler, Cerulean Warbler, Black-billed Cuckoo, and Red-headed Woodpecker. There are many large urban centers in this area whose growth and sprawl will continue to consume land. The vast majority of the presettlement forest and

  2. 26 CFR 1.501(c)(16)-1 - Corporations organized to finance crop operations.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Corporations organized to finance crop operations. 1.501(c)(16)-1 Section 1.501(c)(16)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Exempt Organizations § 1.501(c)(16)-1 Corporations organized to finance crop...

  3. Inclusive quasielastic neutrino reactions in 12C and 16O at intermediate energies

    International Nuclear Information System (INIS)

    Singh, S.K.; Oset, E.

    1993-01-01

    Inclusive quasielastic neutrino (antineutrino) reactions on 12 C and 16 O at intermediate energies (50< E<400 MeV) are studied to investigate the effects of the nuclear medium on the total cross section and the energy spectrum of the outgoing leptons. The calculations are done in the local density approximation and various nuclear effects like Pauli blocking, Fermi motion, and strong-interaction renormalizations due to the presence of nucleons are taken into account. The corrections due to Coulomb effects are included which have been hitherto neglected in inclusive reactions. The results presented here are applicable to the inclusive reactions with neutrino beams planned to look for neutrino oscillations in the Los Alamos experiments or the experiments with underground detectors looking for atmospheric or solar flare neutrinos

  4. Tank 241-C-101 tank characterization plan

    International Nuclear Information System (INIS)

    Schreiber, R.D.

    1994-01-01

    This document is a plan which serves as the contractual agreement between the Characterization Program, Sampling Operations, WHC 222-S Laboratory, and PNL 325 Analytical Chemistry Laboratory. The scope of this plan is to provide guidance for the sampling and analysis of samples from tank 241-C-101

  5. Tank 241-C-105 tank characterization plan

    International Nuclear Information System (INIS)

    Schreiber, R.D.

    1994-01-01

    This document is a plan which serves as the contractual agreement between the Characterization Program, Sampling Operations, WHC 222-S Laboratory, and PNL 325 Analytical Chemistry Laboratory. The scope of this plan is to provide guidance for the sampling and analysis of samples from tank 241-C-105

  6. Use of focus groups in a library's strategic planning process.

    Science.gov (United States)

    Higa-Moore, Mori Lou; Bunnett, Brian; Mayo, Helen G; Olney, Cynthia A

    2002-01-01

    The use of focus groups to determine patron satisfaction with library resources and services is extensive and well established. This article demonstrates how focus groups can also be used to help shape the future direction of a library as part of the strategic planning process. By responding to questions about their long-term library and information needs, focus group participants at the University of Texas Southwestern Medical Center at Dallas Library contributed an abundance of qualitative patron data that was previously lacking from this process. The selection and recruitment of these patrons is discussed along with the line of questioning used in the various focus group sessions. Of special interest is the way the authors utilized these sessions to mobilize and involve the staff in creating the library's strategic plan. This was accomplished not only by having staff members participate in one of the sessions but also by sharing the project's major findings with them and instructing them in how these findings related to the library's future. The authors' experience demonstrates that focus groups are an effective strategic planning tool for libraries and emphasizes the need to share information broadly, if active involvement of the staff is desired in both the development and implementation of the library's strategic plan.

  7. 7 CFR 29.1164 - Cutters (C Group).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Cutters (C Group). 29.1164 Section 29.1164 Agriculture... INSPECTION Standards Grades § 29.1164 Cutters (C Group). This group consists of leaves normally grown at or just below the midportion of the stalk. Leaves of the C group have a tendency to roll concealing the...

  8. Operation REDWING Commander Task Group 7.3, Operation Plan Number 1-56.

    Science.gov (United States)

    1956-01-24

    Radio Circuit Description SI. Tab B - Radio Frequency Plan 7:: Tab C - Aircraft Radio Frequency List Tab D - Radio Circuit Diagram Appendix 2 - Radio...Frequency Plan C Aircraft Radio Frequency List D Radio Circuit Diagrams 2 - Radio Call Signs and Code ’Words N. ROHI5BE2 E LCDR, U. S. Navy Flag...appendix. TABS: A Radio Circuit Description B Radio Frequency Plan C Aircraft Radio Frequency List D Radio Circuit Diagrams Joint Task Force SEVEN Task

  9. α+12C rotational bands in 16O

    Directory of Open Access Journals (Sweden)

    Katsuma M.

    2014-03-01

    Full Text Available The total quantum number N of the α+12C rotational bands in 16O is determined by a study of α+12C elastic scattering. The 8+ and 9− states are found around the excitation energy Ex = 30 MeV and they are the member of the known rotational bands. At the same time, the 02+ state (Ex = 6.05 MeV is found to be dominated by N = 8.

  10. Interaction of pepsin-[C16mim]Br system: interfacial dilational rheology and conformational studies.

    Science.gov (United States)

    Huang, Tian; Cao, Chong; Liu, Zi-lin; Li, Yang; Du, Feng-pei

    2014-09-21

    The interfacial rheological property is closely related to the stabilities of foams and emulsions, yet there have been limited studies on the interaction between proteins with ionic liquid-type imidazolium surfactants at the decane-water interface as well as in the bulk. Herein, we investigated the interfacial and bulk properties of pepsin (PEP) and an ionic liquid (IL), 1-hexadecyl-3-methylimidazolium bromide, [C(16)mim]Br. The interfacial pressure and dilational rheology studies were performed to describe the formation of [C(16)mim]Br-pepsin complexes. The influence of the oscillating frequency and the bulk concentration of [C(16)mim]Br on the dilational properties were explored. The conformational changes were studied by monitoring the fluorescence and far UV-CD spectra. The results reveal that the globular structure of pepsin is one of the decisive factors controlling the nature of the interfacial film. The monotonous increase in the dilational elastic modulus of pepsin-[C(16)mim]Br solutions with the surface age indicates that no loops and tails had formed. Interestingly, with an increase in the concentration of [C(16)mim]Br, the εd-c curve first passes through a plateau value due to steric hindrance and the electrostatic barrier of already absorbed tenacious pepsin-[C(16)mim]Br complexes. With the further addition of [C(16)mim]Br, the remarkable decrease in dilational elastic modulus indicates that the compact structure is destroyed gradually. The results of the fluorescence spectra and far UV-CD spectra confirm that [C(16)mim]Br did not produce perceptible changes in pepsin at the concentrations studied in the dilational experiment. Possible schematic programs of the pepsin-[C(16)mim]Br interaction model at the interface and in bulk phase are proposed.

  11. Reaction 12C(16O,α)24Mg leading to nuclear molecular resonances

    International Nuclear Information System (INIS)

    Nagatani, K.; Shimoda, T.; Tanner, D.; Tribble, R.; Yamaya, T.

    1979-01-01

    The reactions 12 C( 16 O,α) 24 Mg and 13 C( 16 O,α) 25 Mg were investigated at an incident energy of 145 MeV. In the reaction with the 12 C target, broad peaks are observed at forward angles which correspond to the molecular resonance states of the 12 C+ 12 C system, while the spectra with 13 C target show only a smooth continuum

  12. DAF-16: FOXO in the Context of C. elegans.

    Science.gov (United States)

    Tissenbaum, Heidi A

    2018-01-01

    In Caenorhabditis elegans, there is a single FOXO transcription factor homolog, encoded by the gene, daf-16. As a central regulator for multiple signaling pathways, DAF-16 integrates these signals which results in modulation of several biological processes including longevity, development, fat storage, stress resistance, innate immunity, and reproduction. Using C. elegans allows for studies of FOXO in the context of the whole animal. Therefore, manipulating levels or the activity of daf-16 results in phenotypic changes. Genetic and molecular analysis revealed that similar to other systems, DAF-16 is the downstream target of the conserved insulin/IGF-1 signaling (IIS) pathway; a PI 3-kinase/AKT signaling cascade that ultimately controls the regulation of DAF-16 nuclear localization. In this chapter, I will focus on understanding how a single gene daf-16 can incorporate signals from multiple upstream pathways and in turn modulate different phenotypes as well as the study of FOXO in the context of a whole organism. © 2018 Elsevier Inc. All rights reserved.

  13. 19 CFR 206.16 - Industry adjustment plan and commitments.

    Science.gov (United States)

    2010-04-01

    ... Section 206.16 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS, MARKET DISRUPTION, TRADE DIVERSION, AND REVIEW... determination, any firm in the domestic industry, certified or recognized union or group of workers in the...

  14. Controlling a group of microCHPs: planning and realization

    NARCIS (Netherlands)

    Bosman, M.G.C.; Bakker, Vincent; Molderink, Albert; Hurink, Johann L.; Smit, Gerardus Johannes Maria

    2011-01-01

    This paper discusses the planning problem of a group of domestic Combined Heat and Power (microCHP) appliances, which together form a Virtual Power Plant (VPP). To act on an electricity trading market, this VPP has to specify a production plan for electricity for given times of the day to offer to

  15. Planning of Efficient Wireless Access with IEEE 802.16 for Connecting Home Network to the Internet

    Directory of Open Access Journals (Sweden)

    Pichet Ritthisoonthorn

    2010-01-01

    Full Text Available The emergence of IEEE802.16 wireless standard technology (WiMAX has significantly increased the choice to operators for the provisioning of wireless broadband access network. WiMAX is being deployed to compliment with xDSL in underserved or lack of the broadband network area, in both developed and developing countries. Many incumbent operators in developing countries are considering the deployment of WiMAX as part of their broadband access strategy. This paper presents an efficient and simple method for planning of broadband fixed wireless access (BFWA with IEEE802.16 standard to support home connection to Internet. The study formulates the framework for planning both coverage and capacity designs. The relationship between coverage area and access rate from subscriber in each environment area is presented. The study also presents the throughput and channel capacity of IEEE802.16 in different access rates. An extensive analysis is performed and the results are applied to the real case study to demonstrate the practicality of using IEEE 802.16 for connecting home to Internet. Using empirical data and original subscriber traffic from measurement, it is shown that the BFWA with IEEE802.16 standard is a capacity limited system. The capacity of IEEE802.16 is related to different factors including frequency bandwidth, spectrum allocation, estimation of traffic per subscriber, and choice of adaptive modulation from subscriber terminal. The wireless access methods and procedures evolved in this research work and set out in this paper are shown to be well suited for planning BFWA system based on IEEE802.16 which supports broadband home to Internet connections.

  16. 48 CFR 28.307-1 - Group insurance plans.

    Science.gov (United States)

    2010-10-01

    ... requirement. Under cost-reimbursement contracts, before buying insurance under a group insurance plan, the... other refunds to which the contractor may be entitled in the future shall be taken into account. ...

  17. Tank 241-C-107 tank characterization plan

    International Nuclear Information System (INIS)

    Schreiber, R.D.

    1995-01-01

    The Defense Nuclear Facilities Safety Board (DNFSB) has advised the US Department of Energy (DOE) to concentrate the near-term sampling and analysis activities on identification and resolution of safety issues. The data quality objective (DQO) process was chosen as a tool to be used to identify sampling and analytical needs for the resolution of safety issues. As a result, a revision in the Federal Facility Agreement and Consent Order (Tri-Party Agreement or TPA) milestone M-44-00 has been made, which states that ''A Tank Characterization Plan (TCP) will also be developed for each double-shell tank (DST) and single-shell tank (SST) using the DQO process... Development of TCPs by the DQO process is intended to allow users (e.g., Hanford Facility user groups, regulators) to ensure their needs will be met and that resources are devoted to gaining only necessary information.'' This document satisfies that requirement for the Tank 241-C-107 (C-107) sampling activities. Currently tank C-107 is categorized as a sound, low-heat load tank with partial isolation completed in December 1982. The tank is awaiting stabilization. Tank C-107 is expected to contain three primary layers of waste. The bottom layer should contain a mixture of the following wastes: ion exchange, concentrated phosphate waste from N-Reactor, Hanford Lab Operations, strontium semi-works, Battelle Northwest, 1C, TBP waste, cladding waste, and the hot semi-works. The middle layer should contain strontium recovery supernate. The upper layer should consist of non-complexed waste

  18. C5 Extract Induces Apoptosis in B16F10 Murine Melanoma Cells ...

    African Journals Online (AJOL)

    Purpose: To investigate the anti-cancer activities of C5 extract (C5E), a new herbal preparation from Korea, on B16F10 cells. Methods: The anti-proliferative effects of C5E were assessed by culturing B16F10 cells in the presence or absence of C5E. Cell cycle progression was analyzed by PI staining using flow cytometry.

  19. Current calibration, treatment, and treatment planning techniques among institutions participating in the Children's Oncology Group

    International Nuclear Information System (INIS)

    Urie, Marcia; FitzGerald, T.J.; Followill, David; Laurie, Fran; Marcus, Robert; Michalski, Jeff

    2003-01-01

    Purpose: To report current technology implementation, radiation therapy physics and treatment planning practices, and results of treatment planning exercises among 261 institutions belonging to the Children's Oncology Group (COG). Methods and Materials: The Radiation Therapy Committee of the newly formed COG mandated that each institution demonstrate basic physics and treatment planning abilities by satisfactorily completing a questionnaire and four treatment planning exercises designed by the Quality Assurance Review Center. The planning cases are (1) a maxillary sinus target volume (for two-dimensional planning), (2) a Hodgkin's disease mantle field (for irregular-field and off-axis dose calculations), (3) a central axis blocked case, and (4) a craniospinal irradiation case. The questionnaire and treatment plans were submitted (as of 1/30/02) by 243 institutions and completed satisfactorily by 233. Data from this questionnaire and analyses of the treatment plans with monitor unit calculations are presented. Results: Of the 243 clinics responding, 54% use multileaf collimators routinely, 94% use asymmetric jaws routinely, and 13% use dynamic wedges. Nearly all institutions calibrate their linear accelerators following American Association of Physicists in Medicine protocols, currently 16% with TG-51 and 81% with TG-21 protocol. Treatment planning systems are relied on very heavily for all calculations, including monitor units. Techniques and results of each of the treatment planning exercises are presented. Conclusions: Together, these data provide a unique compilation of current (2001) radiation therapy practices in institutions treating pediatric patients. Overall, the COG facilities have the equipment and the personnel to perform high-quality radiation therapy. With ongoing quality assurance review, radiation therapy compliance with COG protocols should be high

  20. Ácido ent-16a,17-diidroxicauran-19-óico isolado de Ouratea semiserrata e os desafios estereoquímicos dos carbonos quirais C-4 e C-16

    Directory of Open Access Journals (Sweden)

    Velandia Javier Rincón

    1998-01-01

    Full Text Available Phytochemical investigation of the leaves and branches of a specimen of Ouratea semiserrata led to the isolation and characterization of ent-16alpha,17-dihydroxykauran-19-oic acid, along with other natural products. This diterpenoid and its derivatives were used to unambiguous ¹H and 13C chemical shifts assignments and to indicate some mistake data described in the literature as consequence mainly of the stereochemicals of the chiral carbons C-4 and C-16. The HRMS spectra were also analysed.

  1. Energy dependence of the 16O + 12C potential of interaction

    Directory of Open Access Journals (Sweden)

    O. A. Ponkratenko

    2013-09-01

    Full Text Available The 16O + 12C scattering data originating from various measurements in the energy range from 1 to 100 MeV/nucleon have been analyzed within optical model (OM. As a result the global energy dependent 16O + 12C - OM-potential has been obtained. Satisfactory description of experimental data is achieved. While analyzing differential cross sections of the elastic scattering and fusion cross sections were calculated using var-ious types of optical potentials.

  2. Plan de negocios Oshian Group

    OpenAIRE

    Castillo Bolivar, Evelyn Johana; Charry López, Ingrid Milena

    2013-01-01

    Plan de negocios para crear una empresa de servicios de importación con contacto directo con proveedores y empresarios chinos para el sector de las Pymes Bogotanas. Oshian Group S.A.S., es una empresa importadora, ubicada en el barrio Chico; inicialmente operará en la ciudad de Bogotá, esto no limita el mercado sino que también se podrá expandir a clientes de otras ciudades del país en mediano o largo plazo. Diferentes sectores económicos como las Pymes han mostrado un avance a través de ...

  3. Perspectives and Plans for Graduate Studies. 16. Biophysics 1974.

    Science.gov (United States)

    Ontario Council on Graduate Studies, Toronto. Advisory Committee on Academic Planning.

    In March, 1973, after a review of the Ontario universities' three-year plans, a provisional embargo was placed on doctoral work in biophysics. A full-scale assessment with outside consultants was not necessary in the case of a provisional embargo. Instead, the method used to remove the embargo was self-study by the discipline group leading to a…

  4. Hydrogenation of the Exocyclic Olefinic Bond at C-16/C-17 Position of ent-Kaurane Diterpene Glycosides of Stevia rebaudiana Using Various Catalysts

    Science.gov (United States)

    Chaturvedula, Venkata Sai Prakash; Prakash, Indra

    2013-01-01

    Catalytic hydrogenation of the exocyclic double bond present between C16 and C17 carbons of the four ent-kaurane diterpene glycosides namely rebaudioside A, rebaudioside B, rebaudioside C, and rebaudioside D isolated from Stevia rebaudiana has been carried out using Pt/C, Pd(OH)2, Rh/C, Raney Ni, PtO2, and 5% Pd/BaCO3 to their corresponding dihydro derivatives with 17α and 17β methyl group isomers. Reactions were performed using the above-mentioned catalysts with the solvents methanol, water, and ethanol/water (8:2) under various conditions. Synthesis of reduced steviol glycosides was performed using straightforward chemistry and their structures were characterized on the basis of 1D and 2D NMR spectral data, including a comparison with reported spectral data. PMID:23896597

  5. Hydrogenation of the Exocyclic Olefinic Bond at C-16/C-17 Position of ent-Kaurane Diterpene Glycosides of Stevia rebaudiana Using Various Catalysts

    Directory of Open Access Journals (Sweden)

    Indra Prakash

    2013-07-01

    Full Text Available Catalytic hydrogenation of the exocyclic double bond present between C16 and C17 carbons of the four ent-kaurane diterpene glycosides namely rebaudioside A, rebaudioside B, rebaudioside C, and rebaudioside D isolated from Stevia rebaudiana has been carried out using Pt/C, Pd(OH2, Rh/C, Raney Ni, PtO2, and 5% Pd/BaCO3 to their corresponding dihydro derivatives with 17α and 17β methyl group isomers. Reactions were performed using the above-mentioned catalysts with the solvents methanol, water, and ethanol/water (8:2 under various conditions. Synthesis of reduced steviol glycosides was performed using straightforward chemistry and their structures were characterized on the basis of 1D and 2D NMR spectral data, including a comparison with reported spectral data.

  6. Visual Grouping in Accordance With Utterance Planning Facilitates Speech Production

    Directory of Open Access Journals (Sweden)

    Liming Zhao

    2018-03-01

    Full Text Available Research on language production has focused on the process of utterance planning and involved studying the synchronization between visual gaze and the production of sentences that refer to objects in the immediate visual environment. However, it remains unclear how the visual grouping of these objects might influence this process. To shed light on this issue, the present research examined the effects of the visual grouping of objects in a visual display on utterance planning in two experiments. Participants produced utterances of the form “The snail and the necklace are above/below/on the left/right side of the toothbrush” for objects containing these referents (e.g., a snail, a necklace and a toothbrush. These objects were grouped using classic Gestalt principles of color similarity (Experiment 1 and common region (Experiment 2 so that the induced perceptual grouping was congruent or incongruent with the required phrasal organization. The results showed that speech onset latencies were shorter in congruent than incongruent conditions. The findings therefore reveal that the congruency between the visual grouping of referents and the required phrasal organization can influence speech production. Such findings suggest that, when language is produced in a visual context, speakers make use of both visual and linguistic cues to plan utterances.

  7. Visual Grouping in Accordance With Utterance Planning Facilitates Speech Production.

    Science.gov (United States)

    Zhao, Liming; Paterson, Kevin B; Bai, Xuejun

    2018-01-01

    Research on language production has focused on the process of utterance planning and involved studying the synchronization between visual gaze and the production of sentences that refer to objects in the immediate visual environment. However, it remains unclear how the visual grouping of these objects might influence this process. To shed light on this issue, the present research examined the effects of the visual grouping of objects in a visual display on utterance planning in two experiments. Participants produced utterances of the form "The snail and the necklace are above/below/on the left/right side of the toothbrush" for objects containing these referents (e.g., a snail, a necklace and a toothbrush). These objects were grouped using classic Gestalt principles of color similarity (Experiment 1) and common region (Experiment 2) so that the induced perceptual grouping was congruent or incongruent with the required phrasal organization. The results showed that speech onset latencies were shorter in congruent than incongruent conditions. The findings therefore reveal that the congruency between the visual grouping of referents and the required phrasal organization can influence speech production. Such findings suggest that, when language is produced in a visual context, speakers make use of both visual and linguistic cues to plan utterances.

  8. Genetic Polymorphism of CYP2C9 Among Sistani Ethnic Group in Gorgan.

    Science.gov (United States)

    Marjani, Abdoljalal; Gharanjik, Aman Mohammad

    2018-04-01

    Cytochrome P450 2C9 (CYP2C9) is involved in metabolism of many important drugs and its genotype variations is thought to affect drug efficacy and the treatment process. The aim of this study was to assess the distribution of CYP2C9 allele and genotypic variants in Sistani ethnic group, living in Gorgan, South East of Caspian Sea and North East of Iran. This study included 140 Sistani, referred to the health center of Gorgan. CYP2C9 genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism technique. The allele frequency of CYP2C9*1, CYP2C9*2 and CYP2C9*3 was 76.1, 16.1 and 7.8%, respectively. The frequency of CYP2C9*1/*1, CYP2C9*1/*2, CYP2C9*1/*3, CYP2C9*2/*2, CYP2C9*2/*3 and CYP2C9*3/*3 genotypes was 53.9, 22.1, 11.4, 2.9, 4.3% and nil, respectively. In this study the genotypic variations of the CYP2C9 allele among the Sistani ethnic group was investigated and great differences were observed in comparison to other populations. Our findings suggest that different genotypes of CYP2C9 may influence the pharmacokinetics of some drugs. More studies on the pharmacokinetic effects of CYP2C9 genotypes may help physicians choose optimal dosage of some drugs for treatment and prevention of their side effects. Since different ethnic groups from all over the world use medications, it suggests to investigate the pharmacokinetic effects of CYP2C9 genotypes in different populations.

  9. Interprofessional collaboration regarding patients' care plans in primary care: a focus group study into influential factors.

    Science.gov (United States)

    van Dongen, Jerôme Jean Jacques; Lenzen, Stephanie Anna; van Bokhoven, Marloes Amantia; Daniëls, Ramon; van der Weijden, Trudy; Beurskens, Anna

    2016-05-28

    The number of people with multiple chronic conditions demanding primary care services is increasing. To deal with the complex health care demands of these people, professionals from different disciplines collaborate. This study aims to explore influential factors regarding interprofessional collaboration related to care plan development in primary care. A qualitative study, including four semi-structured focus group interviews (n = 4). In total, a heterogeneous group of experts (n = 16) and health care professionals (n = 15) participated. Participants discussed viewpoints, barriers, and facilitators regarding interprofessional collaboration related to care plan development. The data were analysed by means of inductive content analysis. The findings show a variety of factors influencing the interprofessional collaboration in developing a care plan. Factors can be divided into 5 key categories: (1) patient-related factors: active role, self-management, goals and wishes, membership of the team; (2) professional-related factors: individual competences, domain thinking, motivation; (3) interpersonal factors: language differences, knowing each other, trust and respect, and motivation; (4) organisational factors: structure, composition, time, shared vision, leadership and administrative support; and (5) external factors: education, culture, hierarchy, domain thinking, law and regulations, finance, technology and ICT. Improving interprofessional collaboration regarding care plan development calls for an integral approach including patient- and professional related factors, interpersonal, organisational, and external factors. Further, the leader of the team seems to play a key role in watching the patient perspective, organising and coordinating interprofessional collaborations, and guiding the team through developments. The results of this study can be used as input for developing tools and interventions targeted at executing and improving interprofessional

  10. Action plan for energy efficiency 2003-2006. A Working Group Proposal

    International Nuclear Information System (INIS)

    2003-02-01

    The updating of the Action Plan for Energy Efficiency is closely related to the need to further intensify measures for promoting energy conservation that was highlighted in the debate in Parliament on the National Climate Strategy and building of a new nuclear power plant. The Working Group with responsibility for the preparation of the updating has made an assessment of the implementation and impact of the previous Action Plan for Energy Efficiency and sought to come up with new measures and ways of increasing the effect of the actions in the previous action plan. The main instruments presented in the updated action plan are developing new technologies, economic instruments, energy conservation agreements, laws and regulations and information and training. The action plan comprises proposals for increasing the budget for energy subsidies for companies and bodies and finding new formulas for the funding of energy saving investments. Further, the aid for the renovation of buildings is proposed to be enhanced. More effort is also needed as concerns disseminating information on energy saving. The development of new technologies requires that the funding from the National Technology Agency (Tekes) for energy efficiency is kept at least at the level of 1999. An implementation of the measures proposed would require a contribution from the state amounting to about E 80 million per year. The system of Energy Conservation Agreements is proposed to be further extended and developed. The agreements could to a larger extent than before cover research and product development processes and processes for purchasing of goods and services. The Working Group proposes further examination of the possibility of imposing binding targets and applying sanctions. Energy taxation is proposed to be developed further in order to promote energy saving and co- generation with the impact of the future Directive on emission allowance trading in mind. New research and development projects are

  11. Plan of development of ZrC-TRISO coated fuel particle and construction of ZrC coater

    Energy Technology Data Exchange (ETDEWEB)

    Ueta, Shohei; Ino, Hiroichi; Sawa, Kazuhiro [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment; Tobita, Tsutomu [Nuclear Engineering Company, Ltd., Tokai, Ibaraki (Japan); Takahashi, Masashi [Nuclear Fuel Industries, Ltd., Tokyo (Japan)

    2002-11-01

    In order to use coated fuel particle under higher temperature condition, more refractory coating material, which is more refractory than conventional silicon carbide (SiC), should be applied. Zirconium carbide (ZrC) is considered to be one of the promising materials, which is proposed as candidate for VHTR fuel material in GENERATION-IV, because of its intactness under high temperature of around 2000degC and its higher stability against kernel migration (amoeba effect) and fission product corrosion under normal operating condition. In order to develop ZrC coated particle for commercial use, research and development items were extracted based on review of the previous works. Research and development plan was determined. Based on the plan, a new ZrC coater of 100g batch size, which applies bromine process, was constructed. This report describes the review of precious works, extracted research and develop items and plan, and specifications of the ZrC coater. (author)

  12. Directing-Group-mediated C-H-Alkynylations.

    Science.gov (United States)

    Caspers, Lucien D; Nachtsheim, Boris J

    2018-05-18

    C-C triple bonds are amongst the most versatile functional groups in synthetic chemistry. Complementary to the Sonogashira coupling the direct metal-catalyzed alkynylation of C-H bonds has emerged as a highly promising approach in recent years. To guarantee a high regioselectivity suitable directing groups (DGs) are necessary to guide the transition metal (TM) into the right place. In this Focus Review we present the current developments in DG-mediated C(sp 2 )-H and C(sp 3 )-H modifications with terminal alkynes under oxidative conditions and with electrophilic alkynylation reagents. We will discuss further modifications of the alkyne, in particular subsequent cyclizations to carbo- and heterocycles and modifications of the DG in the presence of the alkyne. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Nuclear Landau-Zener phenomena and the fusion cross sections in the system 13C + 16O → 12C + 17O

    International Nuclear Information System (INIS)

    Imanishi, B.; Oertzen, W. von.

    1990-07-01

    Reaction mechanism of the system 13 C+ 16 O- 12 C+ 17 O is investigated with the use of the nucleon molecular-orbital model in the framework of the orthogonalized coupled-reaction-channel (OCRC) theory. The adiabatic potentials obtained are quite different from the diagonal potentials of the original OCRC basis. The Landau-Zener radial coupling explains the backward enhancement of measured differential cross sections of the transfer reaction 13 C( 16 O, 17 O) 12 C. In the OCRC calculation the fusion cross sections of the channel 13 C+ 16 O is enhanced at low bombarding energies, in agreement with the experimental data. (author)

  14. The Incorporation of the School Age Group of 16-18 Years Old in Gambling

    Directory of Open Access Journals (Sweden)

    MSc. Alfred Nela

    2015-06-01

    Full Text Available The scientific research of this paper focuses on the involvement of the school age group 16-18 years old in sports betting games impacted by beliefs on luck and social groups. For the collection of data literature is utilized, questionnaires are distributed and also focus groups were conducted. The assumptions of the assignment are: a The involvement of school age group 16-18 years in sports betting games are manners learned from their comrades, b The school age group 16-18 years old attribute to fate the participation in sports betting games. Over 64% of responses manifest that they have learned the rules from their companions. The revelations and questionnaire responses argue that over 45% of students in their classes play sports bets, and 34% think that the phenomena of sports betting depends on luck. The major part of this age group do not practice and believe in fortunate rituals or activities. The acquired data reflect that the extent of involvement of this age group is in substantial dimensions. We suggest that the decision-making bodies and service providers should develop strategies in order to reduce the phenomenon.

  15. 190-C Facility <90 Day Storage Pad training plan

    International Nuclear Information System (INIS)

    Little, N.C.

    1996-12-01

    This is the Environmental Restoration Contractor (ERC) team training plan for the 190-C Facility <90 Day Storage Pad of Hazardous Waste. It is intended to meet the requirements of Washington Administrative Code (WAC) 173-303-330 and the Hanford Dangerous Waste Permit. Training unrelated to compliance with WAC 173-303-330 is not addressed in this training plan. WAC 173-303-330(1)(d)(ii, v, vi) requires that personnel be familiarized, where applicable, with waste feed cut-off systems, response to ground-water contamination incidents, and shutdown of operations. These are not applicable to 190-C Facility <90 Day Storage Pad, and are therefore not covered in this training plan

  16. 26 CFR 1.381(c)(11)-1 - Contributions to pension plan, employees' annuity plans, and stock bonus and profit-sharing plans.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Contributions to pension plan, employees... TAXES Insolvency Reorganizations § 1.381(c)(11)-1 Contributions to pension plan, employees' annuity... or transferor corporation in respect of any pension, annuity, stock bonus, or profit-sharing plan. (b...

  17. F-16 Media Selection and Utilization Plan Report.

    Science.gov (United States)

    1981-03-01

    F0260A-79-C-887S Eommhhmhhhhhmu EmhEmhEEohhhEE Efl ~fflflEfl EN 11111 ~ ~ 111 5_______ III mi o - ~ I I . I 1 N I t 1 , I F16 AIRCREW TRAININgN...two to three objectives per segment, and the types of objective (and thus the type of instructional strategy required to teach it) will not be mixed... teaching of a given objective can be identified. Since the medium is the device for presenting displays and handling all interactions between the student

  18. A PARTIAL ASSESSMENT OF THE WILL C. WOOD JUNIOR HIGH SCHOOL NONGRADED PLAN OF ORGANIZATION.

    Science.gov (United States)

    DELAVAN, FRANK E.; HARTWIG, KEITH E.

    THE NONGRADED PLAN OF SCHOOL ORGANIZATION PUT INTO EFFECT AT SACRAMENTO'S WILL C. WOOD JUNIOR HIGH SCHOOL IN 1964 WAS EVALUATED AND COMPARED WITH GRADED PROGRAMS AT OTHER SCHOOLS BY MEANS OF STANDARDIZED TESTS AND TEACHER OPINIONS. THE POPULATION OF THE STUDY CONSISTED OF THREE PUPIL GROUPS--(1) 212 PUPILS WHO WERE IN THE SEVENTH GRADE DURING THE…

  19. A Collaborative Approach to Transportation Planning: Federal and State Perspectives on Section 180(c) Program Development

    International Nuclear Information System (INIS)

    Macaluso, C.; Strong, T.; Janairo, L.; Helvey, E.

    2006-01-01

    The Department of Energy's Office of Civilian Radioactive Waste Management (OCRWM) committed in its November 2003 Strategic Plan for the Safe Transportation of Spent Nuclear Fuel and High-Level Radioactive Waste to Yucca Mountain: A Guide to Stakeholder Interactions to develop the transportation system collaboratively with stakeholders. The Strategic Plan further stated that four state regional groups (SRGs) would be the 'anchors' for OCRWM's collaboration with the states. The first major transportation planning activity that OCRWM initiated after publication of the Strategic Plan was the development of the Section 180(c) grant program. This document describes that collaboration and its outcomes from the perspective of the OCRWM participants and one of the SRGs, the Council of State Governments - Midwestern Office (CSG Midwest). (authors)

  20. Homologation of hexopyranosides: use of differential Overhauser nuclear effect, and homo- and heteronuclear correlations of chemical shift for characterization of the 1,6-anhydro-4-O-benzoyl-2,3-didesoky-3-C-trifluoroacetamidomethyl-{beta}-D-m = ethyl ribopyranoside (16a); Homologacao de hexopiranosideos: utilizacao de efeito nuclear overhauser diferencial e de correlacoes homo e heteronuclear de deslocamentos quimicos para a caracterizacao do 1,6-anidro-4-O-benzoil-2,3-didesoxi-3-C- trifluoroacetamidometil-{beta}-D-ribo piranosideo de metila (16a)

    Energy Technology Data Exchange (ETDEWEB)

    Souza Filho, J D; Silva, L.G. Fonseca e; Oliveira, A Braga de; Alves, R Jose [Minas Gerais Univ., Belo Horizonte, MG (Brazil); Lukacs, G [Centre National de la Recherche Scientifique (CNRS), 91 - Gif-sur-Yvette (France). Inst. de Chimie des Substances Naturelles

    1992-12-31

    The discovery of ramified sugars as various antibiotics constituents, leads to the development of various preparation technologies. In the framework of hexa pyranose analogues synthesis, the 1,6-anhydride -16a was one of the byproducts obtained in the attempt of bromide -16 derivative transformation in the iodate -6-1 derivative. The bromide -16 derivative was treated with 2 equivalents of Bu{sub 4} N I during 24 hours, acetonitrile reflux. 3 parts of 2 Bu{sub 4} N I equivalents were added each 24 hours. A unique pure substance was obtained from the formed products mixture, which the structural determination was proposed in accordance with: 1) disappearing of the C-13 signal and the two protons from the anomeric methoxy group, and 2) registering of the molecular ion with m/z 359D, corresponding to the loss of 94D (Br + C H{sub 3}), from the -16 (M{sup +}., m/z 453D). The 1,6-anhydride -16a structure was confirmed by experiments on homo- and heteronuclear correlations of chemical shifts (COSY H-H and COSY C-H), and by spectroscopy using the differential Overhauser nuclear effect. The spectrum obtained by C-H correlation identified the singlet at 5.65 ppm as due to the H-1 ([C-1 x H-1]) 2 refs., 6 figs.

  1. HIGH-PRECISION C17O, C18O, AND C16O MEASUREMENTS IN YOUNG STELLAR OBJECTS: ANALOGUES FOR CO SELF-SHIELDING IN THE EARLY SOLAR SYSTEM

    International Nuclear Information System (INIS)

    Smith, Rachel L.; Young, Edward D.; Pontoppidan, Klaus M.; Morris, Mark R.; Van Dishoeck, Ewine F.

    2009-01-01

    Using very high resolution (λ/Δλ ∼ 95 000) 4.7 μm fundamental and 2.3 μm overtone rovibrational CO absorption spectra obtained with the Cryogenic Infrared Echelle Spectrograph infrared spectrometer on the Very Large Telescope (VLT), we report detections of four CO isotopologues-C 16 O, 13 CO, C 18 O, and the rare species, C 17 O-in the circumstellar environment of two young protostars: VV CrA, a binary T Tauri star in the Corona Australis molecular cloud, and Reipurth 50, an intermediate-mass FU Ori star in the Orion Molecular Cloud. We argue that the observed CO absorption lines probe a protoplanetary disk in VV CrA, and a protostellar envelope in Reipurth 50. All CO line profiles are spectrally resolved, with intrinsic line widths of ∼3-4 km s -1 (FWHM), permitting direct calculation of CO oxygen isotopologue ratios with 5%-10% accuracy. The rovibrational level populations for all species can be reproduced by assuming that CO absorption arises in two temperature regimes. In the higher temperature regime, in which the column densities are best determined, the derived oxygen isotope ratios in VV CrA are: [C 16 O]/[C 18 O] =690 ± 30; [C 16 O]/[C 17 O] =2800 ± 300, and [C 18 O]/[C 17 O]=4.1 ± 0.4. For Reipurth 50, we find [C 16 O]/[C 18 O] =490 ± 30; [C 16 O]/[C 17 O] =2200 ± 150, [C 18 O]/[C 17 O] = 4.4 ± 0.2. For both objects, 12 C/ 13 C are on the order of 100, nearly twice the expected interstellar medium (ISM) ratio. The derived oxygen abundance ratios for the VV CrA disk show a significant mass-independent deficit of C 17 O and C 18 O relative to C 16 O compared to ISM baseline abundances. The Reipurth 50 envelope shows no clear differences in oxygen CO isotopologue ratios compared with the local ISM. A mass-independent fractionation can be interpreted as being due to selective photodissociation of CO in the disk surface due to self-shielding. The deficits in C 17 O and C 18 O in the VV CrA protoplanetary disk are consistent with an analogous

  2. Tank 241-C-103 tank characterization plan. Revision 1

    International Nuclear Information System (INIS)

    Schreiber, R.D.

    1995-01-01

    This document is a plan which serves as the contractual agreement between the Characterization Program, Sampling Operations, WHC 222-S Laboratory, and PNL 325 Analytical Chemistry Laboratory. The scope of this plan is to provide guidance for the sampling and analysis of samples from tank 241-C-103

  3. Reclassification of the Candida haemulonii Complex as Candida haemulonii (C. haemulonii Group I), C. duobushaemulonii sp. nov. (C. haemulonii Group II), and C. haemulonii var. vulnera var. nov.: Three Multiresistant Human Pathogenic Yeasts

    NARCIS (Netherlands)

    Cendejas-Bueno, E.; Kolecka, A.; Alastruey-Izquierdo, A.; Theelen, B.; Groenewald, M.; Kostrzewa, M.; Cuenca-Estrella, M.; Gomez-Lopez, A.; Boekhout, T.

    2012-01-01

    The Candida haemulonii species complex is currently known as C. haemulonii groups I and II. Here we describe C. haemulonii group II as a new species, Candida duobushaemulonii sp. nov., and C. haemulonii var. vulnera as new a variety of C. haemulonii group I using phenotypic and molecular methods.

  4. 7 CFR 29.2438 - Thin Leaf (C Group).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Thin Leaf (C Group). 29.2438 Section 29.2438... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2438 Thin Leaf (C Group). This group consists of leaves... body than those of the B group, and show little or no ground injury. Choice- and fine-quality tobacco...

  5. Groups challenge US role in planned Chinese project

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    Environmental groups have threatened to sue the Bureau of Reclamation and the Corps of Engineers over the Agencies role in the construction and planning of China's Three Gorges Dam. They allege the Agencies have violated the Endangered Species Act by failing to notify the US Fish and Wildlife Service about their work on the dam. The environmental group wants to change a 1986 regulation which exempts federal agencies from consulting with the Fish and Wildlife Service on actions affecting endangered species outside the US

  6. Transgenic C. elegans dauer larvae expressing hookworm phospho null DAF-16/FoxO exit dauer.

    Directory of Open Access Journals (Sweden)

    Verena Gelmedin

    Full Text Available Parasitic hookworms and the free-living model nematode Caenorhabtidis elegans share a developmental arrested stage, called the dauer stage in C. elegans and the infective third-stage larva (L3 in hookworms. One of the key transcription factors that regulate entrance to and exit from developmental arrest is the forkhead transcription factor DAF-16/FoxO. During the dauer stage, DAF-16 is activated and localized in the nucleus. DAF-16 is negatively regulated by phosphorylation by the upstream kinase AKT, which causes DAF-16 to localize out of the nucleus and the worm to exit from dauer. DAF-16 is conserved in hookworms, and hypothesized to control recovery from L3 arrest during infection. Lacking reverse genetic techniques for use in hookworms, we used C. elegans complementation assays to investigate the function of Ancylostoma caninum DAF-16 during entrance and exit from L3 developmental arrest. We performed dauer switching assays and observed the restoration of the dauer phenotype when Ac-DAF-16 was expressed in temperature-sensitive dauer defective C. elegans daf-2(e1370;daf-16(mu86 mutants. AKT phosphorylation site mutants of Ac-DAF-16 were also able to restore the dauer phenotype, but surprisingly allowed dauer exit when temperatures were lowered. We used fluorescence microscopy to localize DAF-16 during dauer and exit from dauer in C. elegans DAF-16 mutant worms expressing Ac-DAF-16, and found that Ac-DAF-16 exited the nucleus during dauer exit. Surprisingly, Ac-DAF-16 with mutated AKT phosphorylation sites also exited the nucleus during dauer exit. Our results suggest that another mechanism may be involved in the regulation DAF-16 nuclear localization during recovery from developmental arrest.

  7. 40 CFR 52.1370 - Identification of plan.

    Science.gov (United States)

    2010-07-01

    ... 1, 1983. (C) Amendments to the ARM, subchapter 10 (Visibility Impact Assessment): section 16.8.1007... Tax Credit), sections 16.8.1601 and 16.8.1602, effective December 27, 1985. (H) Appendix G-2, Montana... February 9, 2001, the Governor of Montana submitted revisions to Montana's Emergency Episode Avoidance Plan...

  8. Stellar Populations in Compact Galaxy Groups: a Multi-wavelength Study of HCGs 16, 22, and 42, Their Star Clusters, and Dwarf Galaxies

    Science.gov (United States)

    Konstantopoulos, I. S.; Maybhate, A.; Charlton, J. C.; Fedotov, K.; Durrell, P. R.; Mulchaey, J. S.; English, J.; Desjardins, T. D.; Gallagher, S. C.; Walker, L. M.; hide

    2013-01-01

    We present a multi-wavelength analysis of three compact galaxy groups, Hickson compact groups (HCGs) 16, 22, and 42, which describe a sequence in terms of gas richness, from space- (Swift, Hubble Space Telescope (HST), and Spitzer) and ground-based (Las Campanas Observatory and Cerro Tololo Inter-American Observatory) imaging and spectroscopy.We study various signs of past interactions including a faint, dusty tidal feature about HCG 16A, which we tentatively age-date at what were thought to be double nuclei in HCG 16C and D into multiple, distinct sources, likely to be star clusters. Beyond our phenomenological treatment, we focus primarily on contrasting the stellar populations across these three groups. The star clusters show a remarkable intermediate-age population in HCG 22, and identify the time at which star formation was quenched in HCG 42. We also search for dwarf galaxies at accordant redshifts. The inclusion of 33 members and 27 "associates" (possible members) radically changes group dynamical masses, which in turn may affect previous evolutionary classifications. The extended membership paints a picture of relative isolation in HCGs 16 and 22, but shows HCG 42 to be part of a larger structure, following a dichotomy expected from recent studies. We conclude that (1) star cluster populations provide an excellent metric of evolutionary state, as they can age-date the past epochs of star formation; and (2) the extended dwarf galaxy population must be considered in assessing the dynamical state of a compact group.

  9. /sup 16/O(/sup 16/O, /sup 12/C)/sup 20/Ne reaction in the framework of the coupled channel formalism

    Energy Technology Data Exchange (ETDEWEB)

    Krause, O; Scheid, W; Greiner, W [Frankfurt Univ. (Germany, F.R.). Inst. fuer Theoretische Physik

    1974-01-01

    The transfer reaction /sup 16/O(/sup 16/O, /sup 12/C)/sup 20/Ne is treated in the coupled channel formalism. The influence of the transfer channels on the intermediate structure in the elastic excitation function is discussed. The /sup 16/O and /sup 20/Ne-nuclei are described in an ..cap alpha..-cluster model.

  10. The BWR owners' group planning guide for life extension

    International Nuclear Information System (INIS)

    Smith, S.K.; Lehnert, D.F.; Locke, R.K.

    1991-01-01

    Extending the operating life of a commercial nuclear power plant has been shown to be economically beneficial to both the utility and the electric customer. As such, many utilities are planning and implementing plant life extension (PLEX) programs. A document has been developed which provides guidance to utilities in formulating a PLEX program plant for one or more boiling water reactor (BWR) plants. The guide has been developed by the BWR Owners' Group Plant Life Extension Committee. The principal bases for this guide were the BWR Pilot and Lead Plant Programs. These programs were used as models to develop the 'base plan' described in this guide. By formulating their program plant utilizing the base plan, utilities will be able to maximize the use of existing evaluations and results. The utility planner will build upon the base plan by adding any tasks or features that are unique to their programs. (author)

  11. Radiation Therapy Planning for Early-Stage Hodgkin Lymphoma: Experience of the International Lymphoma Radiation Oncology Group

    International Nuclear Information System (INIS)

    Maraldo, Maja V.; Dabaja, Bouthaina S.; Filippi, Andrea R.; Illidge, Tim; Tsang, Richard; Ricardi, Umberto; Petersen, Peter M.; Schut, Deborah A.; Garcia, John; Headley, Jayne; Parent, Amy; Guibord, Benoit; Ragona, Riccardo; Specht, Lena

    2015-01-01

    Purpose: Early-stage Hodgkin lymphoma (HL) is a rare disease, and the location of lymphoma varies considerably between patients. Here, we evaluate the variability of radiation therapy (RT) plans among 5 International Lymphoma Radiation Oncology Group (ILROG) centers with regard to beam arrangements, planning parameters, and estimated doses to the critical organs at risk (OARs). Methods: Ten patients with stage I-II classic HL with masses of different sizes and locations were selected. On the basis of the clinical information, 5 ILROG centers were asked to create RT plans to a prescribed dose of 30.6 Gy. A postchemotherapy computed tomography scan with precontoured clinical target volume (CTV) and OARs was provided for each patient. The treatment technique and planning methods were chosen according to each center's best practice in 2013. Results: Seven patients had mediastinal disease, 2 had axillary disease, and 1 had disease in the neck only. The median age at diagnosis was 34 years (range, 21-74 years), and 5 patients were male. Of the resulting 50 treatment plans, 15 were planned with volumetric modulated arc therapy (1-4 arcs), 16 with intensity modulated RT (3-9 fields), and 19 with 3-dimensional conformal RT (2-4 fields). The variations in CTV-to-planning target volume margins (5-15 mm), maximum tolerated dose (31.4-40 Gy), and plan conformity (conformity index 0-3.6) were significant. However, estimated doses to OARs were comparable between centers for each patient. Conclusions: RT planning for HL is challenging because of the heterogeneity in size and location of disease and, additionally, to the variation in choice of treatment techniques and field arrangements. Adopting ILROG guidelines and implementing universal dose objectives could further standardize treatment techniques and contribute to lowering the dose to the surrounding OARs

  12. 16-dimensional smooth projective planes with large collineation groups

    OpenAIRE

    Bödi, Richard

    1998-01-01

    Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch) Smooth projective planes are projective planes defined on smooth manifolds (i.e. the set of points and the set of lines are smooth manifolds) such that the geometric operations of join and intersection are smooth. A systematic study of such planes and of their collineation groups can be found in previous works of the author. We prove in this paper that a 16-dimensional smooth projective plane which admits a ...

  13. IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.

    Science.gov (United States)

    Almine, Jessica F; O'Hare, Craig A J; Dunphy, Gillian; Haga, Ismar R; Naik, Rangeetha J; Atrih, Abdelmadjid; Connolly, Dympna J; Taylor, Jordan; Kelsall, Ian R; Bowie, Andrew G; Beard, Philippa M; Unterholzner, Leonie

    2017-02-13

    Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP). Other putative DNA receptors have been described, but whether their functions are redundant, tissue-specific or integrated in the cGAS-cGAMP pathway is unclear. Here we show that interferon-γ inducible protein 16 (IFI16) cooperates with cGAS during DNA sensing in human keratinocytes, as both cGAS and IFI16 are required for the full activation of an innate immune response to exogenous DNA and DNA viruses. IFI16 is also required for the cGAMP-induced activation of STING, and interacts with STING to promote STING phosphorylation and translocation. We propose that the two DNA sensors IFI16 and cGAS cooperate to prevent the spurious activation of the type I interferon response.

  14. Dicty_cDB: FC-BC16 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC (Link to library) FC-BC16 (Link to dictyBase) - - - Contig-U15105-1 FC-BC16Z (Li...nk to Original site) - - FC-BC16Z 620 - - - - Show FC-BC16 Library FC (Link to library) Clone ID FC-BC16 (Link to dict...yBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U15105-1 Original site URL http://dict...4 2e-66 AY961522_1( AY961522 |pid:none) Lysiphlebus testaceipes ribosomal ... 254 2e-66 AF402813_1( AF402813 |pid:none) Ict...hondrial 4.0 %: nuclear >> prediction for FC-BC16 is cyt 5' end seq. ID - 5' end seq. - Length of 5' end seq

  15. The 12C+α reaction rate from the elastic 16O breakup

    International Nuclear Information System (INIS)

    Kiener, J.; Kraus, L.; Lefebvre, A.; Mittig, W.; Motobayashi, T.; De Oliveira-Santos, F.; Stephan, C.; Thibaud, J.P.

    1997-01-01

    Evidence for direct elastic breakup of 16 O into the α- 12 C continuum with relative energies ranging from 900 to 1800 keV has been obtained in the scattering of 1527 MeV 16 O projectiles off 208 Pb. An interpretation of E2 breakup including nuclear and Coulomb contributions leads to reduced electromagnetic transition probabilities and astrophysical S E2 factors in reasonable agreement with direct measurements, showing that the method can be applied to extract the E2 part of the 12 C(α,γ) reaction rate. (orig.)

  16. 76 FR 46677 - Requirements for Group Health Plans and Health Insurance Issuers Relating to Coverage of...

    Science.gov (United States)

    2011-08-03

    ... Requirements for Group Health Plans and Health Insurance Issuers Relating to Coverage of Preventive Services... regulations published July 19, 2010 with respect to group health plans and health insurance coverage offered... plans, and health insurance issuers providing group health insurance coverage. The text of those...

  17. Non commutative geometry methods for group C*-algebras

    International Nuclear Information System (INIS)

    Do Ngoc Diep.

    1996-09-01

    This book is intended to provide a quick introduction to the subject. The exposition is scheduled in the sequence, as possible for more understanding for beginners. The author exposed a K-theoretic approach to study group C * -algebras: started in the elementary part, with one example of description of the structure of C * -algebra of the group of affine transformations of the real straight line, continued then for some special classes of solvable and nilpotent Lie groups. In the second advanced part, he introduced the main tools of the theory. In particular, the conception of multidimensional geometric quantization and the index of group C * -algebras were created and developed. (author). Refs

  18. The central subgroup of the nonabelian tensor square of Bieberbach group of dimension three with point group C2 × C2

    Science.gov (United States)

    Ladi, Nor Fadzilah Abdul; Masri, Rohaidah; Idrus, Nor'ashiqin Mohd; Ting, Tan Yee

    2017-05-01

    Bieberbach groups are crystallographic groups. By computing the central subgroup of the nonabelian tensor square of a group, the properties of the group can be determined. In this paper, the central subgroup of the nonabelian tensor square of one Bieberbach group of dimension three with point group C2 × C2 is computed. In order to compute the ∇ (S3 (3)), the derived subgroup and the abelianization of the group are first constructed.

  19. A 3-Component Approach Incorporating Focus Groups in Strategic Planning for Sexual Violence Prevention.

    Science.gov (United States)

    Cruz, Theresa H; Hess, Julia Meredith; Woelk, Leona; Bear, Samantha

    2016-01-01

    Sexual violence is of special concern in New Mexico because of the presence of large priority populations in which its prevalence is high. This article describes a 3-component approach to developing a strategic plan to prevent sexual violence in the state that consisted of an advisory group, subject matter experts, and focus groups from geographically and demographically diverse communities. Both common and community-specific themes emerged from the focus groups and were included in the strategic plan. By incorporating community needs and experiences, this approach fosters increased investment in plan implementation.

  20. [Study on immunogenicity of group A and group C meningococcal conjugate vaccine with coupling group B meningococcal outer membrane protein].

    Science.gov (United States)

    Ma, Fu-Bao; Tao, Hong; Wang, Hong-Jun

    2009-10-01

    To evaluate the Immunogenicity of Group A and Group C Meningococcal conjugate Vaccine with coupling Group B Meningococcal Outer Membrane Protein (Men B-OMP). 458 healthy children aged 3-5 months, 6-23 months, 2-6 years and 7-24 years were given the Groups A and C conjugate Vaccine with MenB-OMP or other vaccine as control group to measure the pre-and post-vaccination Men A and C and B by Serum Bactericidal Assay (SBA) in the double-blind randomized controlled trial. 97.65%-100% were 4 times or greater increase in SBA titer for the healthy children given the Groups A and C conjugate Vaccine with MenB-OMP, The geometric mean titer of SBA were 1:194-1:420, which significantly higber than controls. The Group A and C conjugate Vaccine with MenB-OMP was safe and well immunogenic.

  1. The Physics and Applications of High Brightness Beams: Working Group C Summary on Applications to FELS

    International Nuclear Information System (INIS)

    Nuhn, Heinz-Dieter

    2003-01-01

    This is the summary of the activities in working group C, ''Application to FELs,'' which was based in the Bithia room at the Joint ICFA Advanced Accelerator and Beam Dynamics Workshop on July 1-6, 2002 in Chia Laguna, Sardinia, Italy. Working group C was small in relation to the other working groups at that workshop. Attendees include Enrica Chiadroni, University of Rome ape with an identical pulse length. ''La Sapienza'', Luca Giannessi, ENEA, Steve Lidia, LBNL, Vladimir Litvinenko, Duke University, Patrick Muggli, UCLA, Alex Murokh, UCLA, Heinz-Dieter Nuhn, SLAC, Sven Reiche, UCLA, Jamie Rosenzweig, UCLA, Claudio Pellegrini, UCLA, Susan Smith, Daresbury Laboratory, Matthew Thompson, UCLA, Alexander Varfolomeev, Russian Research Center, plus a small number of occasional visitors. The working group addressed a total of nine topics. Each topic was introduced by a presentation, which initiated a discussion of the topic during and after the presentation. The speaker of the introductory presentation facilitated the discussion. There were six topics that were treated in stand-alone sessions of working group C. In addition, there were two joint sessions, one with working group B, which included one topic, and one with working group C, which included two topics. The presentations that were given in the joint sessions are summarized in the working group summary reports for groups B and D, respectively. This summary will only discuss the topics that were addressed in the stand-alone sessions, including Start-To-End Simulations, SASE Experiment, PERSEO, ''Optics Free'' FEL Oscillators, and VISA II

  2. 76 FR 37037 - Requirements for Group Health Plans and Health Insurance Issuers Relating to Internal Claims and...

    Science.gov (United States)

    2011-06-24

    ... Requirements for Group Health Plans and Health Insurance Issuers Relating to Internal Claims and Appeals and... interim final regulations published July 23, 2010 with respect to group health plans and health insurance..., group health plans, and health insurance issuers providing group health insurance coverage. The text of...

  3. IMRT treatment planning-A comparative inter-system and inter-centre planning exercise of the ESTRO QUASIMODO group

    International Nuclear Information System (INIS)

    Bohsung, Joerg; Gillis, Sofie; Arrans, Rafael; Bakai, Annemarie; De Wagter, Carlos; Knoeoes, Tommy; Mijnheer, Ben J.; Paiusco, Marta; Perrin, Bruce A.; Welleweerd, Hans; Williams, Peter

    2005-01-01

    Background and purpose: The purpose of this work was a comparison of realistic IMRT plans based on the same CT-image data set and a common predefined set of dose objectives for the planning target volume and the organs at risk. This work was part of the larger European QUASIMODO IMRT verification project. Materials and methods: Eleven IMRT plans were produced by nine different European groups, each applying a representative set of clinically used IMRT treatment planning systems. The plans produced were to be deliverable in a clinically acceptable treatment time with the local technical equipment. All plans were characterized using a set of different quality measures such as dose-volume histograms, number of monitor units and treatment time. Results: Only one plan was able to fulfil all dose objectives strictly; six plans failed some of the objectives but were still considered to be clinically acceptable; four plans were not able to reach the objectives. Additional quality scores such as the number of monitor units and treatment time showed large variations, which mainly depend on the delivery technique. Conclusion: The presented planning study showed that with nearly all presently available IMRT planning and delivery systems comparable dose distributions could be achieved if the planning goals are clearly defined in advance

  4. Identification of long and very long chain fatty acids, plasmalogen-C16:0 and phytanic acid as new lipid biomarkers in Tunisian coronary artery disease patients.

    Science.gov (United States)

    Hadj Ahmed, Samia; Koubaa, Nadia; Kharroubi, Wafa; Zarrouk, Amira; Mnari, Amira; Batbout, Fethi; Gamra, Habib; Hammami, Sonia; Lizard, Gérard; Hammami, Mohamed

    2017-07-01

    Long and very long chain fatty acids (LCFAs and VLCFAs) may play an active role in coronary artery diseases (CAD) etiology. Our aim was to evaluate the associations between LCPUFAs (C20:4n-6; C20:5n-3 and C22:6n-3) and VLCSFAs (C22:0, C24:0; and C26:0), as well as markers of peroxisomal integrity evaluated by phytanic acid and plasmalogen-C16:0 (PL-C16:0) in addition to the markers of lipid peroxidation (malondialdehyde [MDA] and conjugated dienes [CD]) and inflammation (high sensitivity C-reactive protein [hs-CRP]) with vascular severity evaluated by Gensini score in order to determine their possible effects on CAD in Tunisian population. Lipidomic strategy based on GC/MS-SIM was used to quantify LCPUFAs, VLCSFAs, and PL-C16:0 in red blood cells of CAD patients, non-CAD patients, and controls. We observed a significant increase in phytanic acid, PL-C16:0 and VLCFAs, particularly C26:0, in CAD group compared to controls. Further our findings showed positive correlations of C26:0 with MDA and with vascular severity score (Gensini score). In addition, a significant negative correlation was shown between hs-CRP and C22:6 n-3 (r=-0.297; p=0.002) and a significant positive association was observed between hs-CRP and C20:4 n-6 levels (r=0.196; p=0.039). Our results show changes in LCPUFAs and VLCSFAs concentrations in RBC among study groups, and suggest alterations in fatty acids metabolism regulated by elongase and desaturase enzymes. The positive correlations of C20:4n-6 and the negative correlations of C22:6n-3, simultaneously with Gensini score and hs-CRP, suggest a link of both inflammation and vascular severity complication of CAD with LCPUFAs and VLCSFAs. Induction of lipid oxidation, can be one of the outcomes of LCFAs and VLCFAs accumulation in vascular tissues and, thus, playing an important role in the pathogenesis of atherosclerosis. Quantification of LCPUFAs and VLCSFAs, phytanic acid and PL-C16:0 simultaneously, would be of great value for the screening of

  5. Indiana University High Energy Physics Group, Task C

    International Nuclear Information System (INIS)

    Heinz, R.M.; Mufson, S.L.; Musser, J.

    1991-01-01

    The Indiana University High Energy Physics Group, Task C has been actively involved in the MACRO experiment at Gran Sasso and the SSC experiment L during the current contract year. MACRO is a large US-Italian Monopole, Astrophysics, and Cosmic Ray Observatory being built under the Gran Sasso Mountain outside of Rome. Indiana University is in charge of organizing the United States software effort. We have built a state-of-the-art two-meter spectrophotometer for the MACRO liquid scintillator. We are in charge of ERP, the Event Reconstruction Processor online trigger processor for muons and stellar collapse. We are designing an air Cerenkov array to be placed on top of the Gran Sasso. Our other activity involves participation in the SSC experiment L. As long-standing members of L we have done proposal writing and have worked on important L planning and organization matters. We are now doing development work on the L Central Tracker straw drift tubes, including gas optimization, readout, and Monte Carlos. 12 refs., 20 figs., 1 tab

  6. Indiana University High Energy Physics Group, Task C

    Energy Technology Data Exchange (ETDEWEB)

    Heinz, R.M.; Mufson, S.L.; Musser, J.

    1991-01-01

    The Indiana University High Energy Physics Group, Task C has been actively involved in the MACRO experiment at Gran Sasso and the SSC experiment L during the current contract year. MACRO is a large US-Italian Monopole, Astrophysics, and Cosmic Ray Observatory being built under the Gran Sasso Mountain outside of Rome. Indiana University is in charge of organizing the United States software effort. We have built a state-of-the-art two-meter spectrophotometer for the MACRO liquid scintillator. We are in charge of ERP, the Event Reconstruction Processor online trigger processor for muons and stellar collapse. We are designing an air Cerenkov array to be placed on top of the Gran Sasso. Our other activity involves participation in the SSC experiment L. As long-standing members of L we have done proposal writing and have worked on important L planning and organization matters. We are now doing development work on the L Central Tracker straw drift tubes, including gas optimization, readout, and Monte Carlos. 12 refs., 20 figs., 1 tab.

  7. General developments in the Los Alamos Nuclear Physics group (T-16)

    International Nuclear Information System (INIS)

    Young, P.G.; Chadwick, M.B.

    2000-01-01

    Nuclear physics activities in support of nuclear data development by the newly formed ''Nuclear Physics'' group (T-16) at Los Alamos are summarized. Activities such as the development of a new Hauser-Feshbach/preequilibrium reaction theory code, improvements to and reissue of the existing GNASH reaction theory code, nuclear cross section evaluation in the context of ENDF/B-VI, development of a new medium-energy optical model potential, new fission neutron spectrum calculations with the Los Alamos model, and development of new 6-group delayed neutron constants for ENDF/B-VI are described. (author)

  8. 75 FR 27121 - Interim Final Rules for Group Health Plans and Health Insurance Issuers Relating to Dependent...

    Science.gov (United States)

    2010-05-13

    ... 45 CFR Parts 144, 146, and 147 Group Health Plans and Health Insurance Issuers Relating to Dependent... 144, 146, and 147 RIN 0991-AB66 Interim Final Rules for Group Health Plans and Health Insurance... requirements for group health plans and health insurance issuers in the group and individual markets under...

  9. 33 CFR Appendix C to Part 155 - Training Elements for Oil Spill Response Plans

    Science.gov (United States)

    2010-07-01

    .... 155, App. C Appendix C to Part 155—Training Elements for Oil Spill Response Plans 1. General 1.1The portion of the plan dealing with training is one of the key elements of a response plan. This concept is... included training as one of the sections required in a vessel or facility response plan. In reviewing...

  10. Dyslexia: Group Screening among 15-16-Year-Olds in Oslo, Norway

    Science.gov (United States)

    Green, K.; Tonnessen, F. E.; Tambs, K.; Thoresen, M.; Bjertness, E.

    2009-01-01

    In 15-16 year olds from Oslo, Norway, we investigated the occurrence of self-reported dyslexia and reading/writing difficulties (RWD), and we measured dyslexic symptoms using the "Duvan" dyslexia screening test. The prevalence of self-reported dyslexia was 8.2%, while 10.4% reported severe or moderate RWD. The group of self-reported…

  11. 13C(α,n)16O reaction as the knock-out exchange process

    International Nuclear Information System (INIS)

    Kim, G.; Khajdarov, R.R.; Zaparov, Eh.A.

    2000-01-01

    S-factor for the 13 C(α,n) 16 O reaction is studied. In the framework of the simple phenomenological model this reaction is analysed as neutron knocked-out by α-particle exchange process. The analysis demonstrates the importance of taking into account 2p-state in 13 C. The 13 C(α,n) 16 O cross section is considered both as the knock-out exchange process and as it's combination with process through a compound nucleus. It was shown that for E α s value extrapolated to low energies is found to be noticeably larger that of R-matrix analysis. Different ways of improving the proposed model are discussed. (author)

  12. K-theory for group C*-algebras and semigroup C*-algebras

    CERN Document Server

    Cuntz, Joachim; Li, Xin; Yu, Guoliang

    2017-01-01

    This book gives an account of the necessary background for group algebras and crossed products for actions of a group or a semigroup on a space and reports on some very recently developed techniques with applications to particular examples. Much of the material is available here for the first time in book form. The topics discussed are among the most classical and intensely studied C*-algebras. They are important for applications in fields as diverse as the theory of unitary group representations, index theory, the topology of manifolds or ergodic theory of group actions.

  13. 76 FR 37207 - Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims and Appeals...

    Science.gov (United States)

    2011-06-24

    ... Department of Health and Human Services 45 CFR Part 147 Group Health Plans and Health Insurance Issuers... SERVICES [CMS-9993-IFC2] 45 CFR Part 147 RIN 0938-AQ66 Group Health Plans and Health Insurance Issuers... for group health plans and health insurance coverage in the group and individual markets under...

  14. States of 15C via the (18O,16O) reaction

    CERN Document Server

    Cappuzzello, F; Cunsolo, A; Foti, A; Orrigo, S E A; Rodrigues, M R D; Borello-Lewin, T; Carbone, D; Schillaci, C

    2010-01-01

    A study of the 15C states was pursued in 2008 at the Catania INFN-LNS laboratory by the 13C(18O,16O)15C reaction at 84 MeV incident energy. The 16O ejectiles were detected at forward angles by the MAGNEX magnetic spectrometer. Thanks to an innovative technique the ejectiles were identified without the need of time of flight measurements. Exploiting the large momentum acceptance (25%) and solid angle (50 msr) of the spectrometer, the 15C energy spectra were obtained with a quite relevant yield up to about 20 MeV excitation energy. The application of the powerful technique of the trajectory reconstruction did allow to get an energy resolution of about 250 keV FWHM, limited mainly by straggling effects. The spectra show several known low lying states up to about 7 MeV excitation energy as well as two unknown resonant structures at about 11.4 and 13.5 MeV. The strong excitation of these latter together with the measured width of about 2 MeV FWHM could indicate the presence of collective modes of excitation connec...

  15. Research Award: Policy and Planning Group (PPG) Deadline: 12 ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Jean-Claude Dumais

    2012-09-12

    Sep 12, 2012 ... mentorship in research, research management, and grant administration allows research awardees to pursue their research goals in a dynamic team environment in one of the world's leaders in generating new knowledge to meet global challenges. The Policy and Planning Group (PPG) is responsible for ...

  16. 76 FR 44491 - Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims and Appeals...

    Science.gov (United States)

    2011-07-26

    ... 37208) entitled, ``Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims..., ``Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims and Appeals and... external review processes for group health plans and health insurance issuers offering coverage in the...

  17. 75 FR 70159 - Group Health Plans and Health Insurance Coverage Rules Relating to Status as a Grandfathered...

    Science.gov (United States)

    2010-11-17

    ... Group Health Plans and Health Insurance Coverage Rules Relating to Status as a Grandfathered Health Plan... contracts of insurance. The temporary regulations provide guidance to employers, group health plans, and health insurance issuers providing group health insurance coverage. The IRS is issuing the temporary...

  18. Drugs and personality: comparison of drug users, nonusers, and other clinical groups on the 16PF.

    Science.gov (United States)

    Spotts, J V; Shontz, F C

    1991-10-01

    This article reviews published 16PF research on drug users. It also compares the 16PF scores of a new sample of nonusers with scores of matched groups of heavy, chronic users of cocaine, amphetamine, opiates, and barbiturates/sedative hypnotics, as well as combined groups of stimulant users, depressant users, and a combined group of users of all substances. No significant differences were found among drug user groups, but the profile of the nonuser group was distinctive. K-Means Cluster Analyses, as well as Cattell's Similarity and Pearson Product Moment Correlation Coefficients, were used to compare profiles of these new samples with the 19 groups described in an earlier meta-analysis of published 16PF studies. Data from the new samples did not cluster with data from other published research, although certain specific similarities appeared in more detailed correlational analyses. Methodological problems are discussed, and it is recommended that in future studies drug user groups be more carefully selected and defined, sample descriptions be more thorough and complete, complete profile information be routinely provided, and efforts be made to explore the utility of the Cattell CAQ in studies of drug users/misusers.

  19. Gold electrodes modified with 16H, 18H-dibenzo[c,l]-7,9-dithia-16,18-diazapentacene for electrocatalytic oxidation of NADH

    NARCIS (Netherlands)

    Rosca, V.; Muresan, L.; Popescu, I.C.; Cristea, C.; Silberg, I.A.

    2001-01-01

    16H,18H-Dibenzo[c,l]-7,9-dithia-16,18-diazapentacene (DDDP), a new phenothiazine derivative containing two linearly condensed phenothiazine rings, strongly adsorbs on polyoriented gold resulting in a modified electrode with electrocatalytic activity for ß-nicotinamide adenine dinucleotide (NADH)

  20. Further evidence for resonance anomalies in the 12C + 16O system

    International Nuclear Information System (INIS)

    Branford, D.; Nagorcka, B.N.; Newton, J.O.

    1977-09-01

    Excitation functions for six nuclides resulting from the 16 O + 12 C reaction, as well as for inelastic scattering to the 3 - state of 16 O, have been measured by γ-ray techniques in the range Esub(cm) = 12.8 - 18.2 MeV and a complete fusion excitation function deduced. Resonance anomalies, which may be due to the excitation of quasimolecular states, are observed at 14.7, 16.7, 17.6 and 18.6 MeV. These and other results are considered in terms of theoretical models for quasimolecular states. (Author)

  1. STELLAR POPULATIONS IN COMPACT GALAXY GROUPS: A MULTI-WAVELENGTH STUDY OF HCGs 16, 22, AND 42, THEIR STAR CLUSTERS, AND DWARF GALAXIES

    International Nuclear Information System (INIS)

    Konstantopoulos, I. S.; Maybhate, A.; Charlton, J. C.; Gronwall, C.; Fedotov, K.; Desjardins, T. D.; Gallagher, S. C.; Durrell, P. R.; Mulchaey, J. S.; English, J.; Walker, L. M.; Johnson, K. E.; Tzanavaris, P.

    2013-01-01

    We present a multi-wavelength analysis of three compact galaxy groups, Hickson compact groups (HCGs) 16, 22, and 42, which describe a sequence in terms of gas richness, from space- (Swift, Hubble Space Telescope (HST), and Spitzer) and ground-based (Las Campanas Observatory and Cerro Tololo Inter-American Observatory) imaging and spectroscopy. We study various signs of past interactions including a faint, dusty tidal feature about HCG 16A, which we tentatively age-date at <1 Gyr. This represents the possible detection of a tidal feature at the end of its phase of optical observability. Our HST images also resolve what were thought to be double nuclei in HCG 16C and D into multiple, distinct sources, likely to be star clusters. Beyond our phenomenological treatment, we focus primarily on contrasting the stellar populations across these three groups. The star clusters show a remarkable intermediate-age population in HCG 22, and identify the time at which star formation was quenched in HCG 42. We also search for dwarf galaxies at accordant redshifts. The inclusion of 33 members and 27 ''associates'' (possible members) radically changes group dynamical masses, which in turn may affect previous evolutionary classifications. The extended membership paints a picture of relative isolation in HCGs 16 and 22, but shows HCG 42 to be part of a larger structure, following a dichotomy expected from recent studies. We conclude that (1) star cluster populations provide an excellent metric of evolutionary state, as they can age-date the past epochs of star formation; and (2) the extended dwarf galaxy population must be considered in assessing the dynamical state of a compact group.

  2. Multiplex quantification of 16S rDNA of predominant bacteria group within human fecal samples by polymerase chain reaction--ligase detection reaction (PCR-LDR).

    Science.gov (United States)

    Li, Kai; Chen, Bei; Zhou, Yuxun; Huang, Rui; Liang, Yinming; Wang, Qinxi; Xiao, Zhenxian; Xiao, Junhua

    2009-03-01

    A new method, based on ligase detection reaction (LDR), was developed for quantitative detection of multiplex PCR amplicons of 16S rRNA genes present in complex mixtures (specifically feces). LDR has been widely used in single nucleotide polymorphism (SNP) assay but never applied for quantification of multiplex PCR products. This method employs one pair of DNA probes, one of which is labeled with fluorescence for signal capture, complementary to the target sequence. For multiple target sequence analysis, probes were modified with different lengths of polyT at the 5' end and 3' end. Using a DNA sequencer, these ligated probes were separated and identified by size and dye color. Then, relative abundance of target DNA were normalized and quantified based on the fluorescence intensities and exterior size standards. 16S rRNA gene of three preponderant bacteria groups in human feces: Clostridium coccoides, Bacteroides and related genera, and Clostridium leptum group, were amplified and cloned into plasmid DNA so as to make standard curves. After PCR-LDR analysis, a strong linear relationship was found between the florescence intensity and the diluted plasmid DNA concentrations. Furthermore, based on this method, 100 human fecal samples were quantified for the relative abundance of the three bacterial groups. Relative abundance of C. coccoides was significantly higher in elderly people in comparison with young adults, without gender differences. Relative abundance of Bacteroides and related genera and C. leptum group were significantly higher in young and middle aged than in the elderly. Regarding the whole set of sample, C. coccoides showed the highest relative abundance, followed by decreasing groups Bacteroides and related genera, and C. leptum. These results imply that PCR-LDR can be feasible and flexible applied to large scale epidemiological studies.

  3. Resonant states in 13C and 16,17O at high excitation energy

    Science.gov (United States)

    Rodrigues, M. R. D.; Borello-Lewin, T.; Miyake, H.; Duarte, J. L. M.; Rodrigues, C. L.; Horodynski-Matsushigue, L. B.; Ukita, G. M.; Cappuzzello, F.; Cavallaro, M.; Foti, A.; Agodi, C.; Cunsolo, A.; Carbone, D.; Bondi, M.; De Napoli, M.; Roeder, B. T.; Linares, R.; Lombardo, I.

    2014-12-01

    The 9Be(6Li,d)13C and 12,13C(6Li,d)16,17O reactions were measured at the São Paulo Pelletron-Enge-Spectrograph facility at 25.5 MeV incident energy. The nuclear emulsion detection technique was applied. Several narrow resonances were populated up to approximately 17 MeV of excitation energy. An excellent energy resolution was obtained: 40 keV for 13C and 15-30 keV for 16O. The upper limit for the resonance widths were determined. Recently, d-a angular correlations were measured at θd = 0° with incident energy of 25 MeV using the LNS Tandem-MAGNEX Spectrometer facility.

  4. Resonant states in 13C and 16,17O at high excitation energy

    International Nuclear Information System (INIS)

    Rodrigues, M R D; Borello-Lewin, T; Miyake, H; Duarte, J L M; Rodrigues, C L; Horodynski-Matsushigue, L B; Ukita, G M; Cappuzzello, F; Foti, A; Cavallaro, M; Agodi, C; Cunsolo, A; Carbone, D; Bondi, M; Napoli, M De; Roeder, B T; Linares, R; Lombardo, I

    2014-01-01

    The 9 Be( 6 Li,d) 13 C and 12,13 C( 6 Li,d) 16,17 O reactions were measured at the São Paulo Pelletron-Enge-Spectrograph facility at 25.5 MeV incident energy. The nuclear emulsion detection technique was applied. Several narrow resonances were populated up to approximately 17 MeV of excitation energy. An excellent energy resolution was obtained: 40 keV for 13 C and 15-30 keV for 16 O. The upper limit for the resonance widths were determined. Recently, d-a angular correlations were measured at θ d = 0° with incident energy of 25 MeV using the LNS Tandem-MAGNEX Spectrometer facility

  5. 7 CFR 407.13 - Group risk plan for forage.

    Science.gov (United States)

    2010-01-01

    ... acres of hay in the county, as specified in the actuarial documents. The actuarial documents will... a period for forage regrowth. 2. Crop Insured The insured crop will be the forage types shown on the... the Group Risk Plan Common Policy, acreage seeded to forage after July 1 of the previous crop year...

  6. The Influence of Selected Leadership Variables on the Effectiveness of Curriculum Planning Groups.

    Science.gov (United States)

    Farrell, Glen Michael

    This study evaluated whether effectiveness in curriculum planning groups is raised by involving a professional adult educator as a nondirective, information giving group member, or by training group chairmen in discussion leadership skills. Group effectiveness was measured by member satisfaction with the group product, satisfaction with…

  7. The effect of educational group therapy plan on self–esteem rate in adolescent girls

    Directory of Open Access Journals (Sweden)

    Roya Turkashvand

    2011-07-01

    Full Text Available Background: Adolescence is a period of major changes in various aspects of physical, mental and social caracters they may get. There are new requirements for the changes have been occurred. Attention to these needs, in turn, are faster and better compatibility and increase self-esteem. Self-esteem is the basic factor of personality development in adolescents. Therefore, the aim of this study was to evaluate the effect of educational group therapy on self-esteem of adolescent girls.Materials and Method: This is a quasi- experimental study. Seventy-one adolescent girls of 13-15 years old were selected cluster-randomly from guidance school and divided in two groups of experimental and control (35 cases, 36 controls. Self-esteem of adolescents in two groups measured using Pop test. Then the educational group therapy plan was utilized based on promotion of adolescent’s self- esteem at 10 sessions for case group. Self-esteem rate was measured just after the performance of planned session and were analyzed with SPSS-14 software.Results: The results of the study indicated that performing educational group therapy session can increase the mean self-esteem score for case group (84.74 comparing to control group (74.05. Independent t-test shows significant difference between self-esteem score in case and control groups.Conclusion: According to our results the authors suggest that using educational group therapy plan is an effective approach in increasing self-esteem in adolescent girls and may improve mental health. Therefore, we suggest this plan for increasing self-esteem of adolescents in the schools

  8. Resonance states in 16O +16O, 12C +16O, α +16O and α +12C

    Indian Academy of Sciences (India)

    Thus starting with two well-separated nuclei in their ground state, ... n = 1, 2. (3) and V0 > 0 with the eight parameters V0, ξ1, ξ2, Rm, d1, d2, VI and aI. This .... in the range L = 4 to 16 are observed within about 30 MeV of excitation. The. 0. 20. 40. 60. 80 .... The characteristics of the potentials show a systematic trend having.

  9. Joint C4ISR Architecture Planning/Analysis System (JCAPS)

    National Research Council Canada - National Science Library

    Wostbrock, Bill

    2002-01-01

    The contractor satisfactorily completed all tasks under both efforts, providing the technology and technical expertise in the development of the Joint C4ISR Architecture Planning/Analysis System (JCAPS) Database Tool...

  10. 29 CFR 5.16 - Training plans approved or recognized by the Department of Labor prior to August 20, 1975.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Training plans approved or recognized by the Department of... STANDARDS ACT) Davis-Bacon and Related Acts Provisions and Procedures § 5.16 Training plans approved or... contractor shall be required to obtain approval of a training program which, prior to August 20, 1975, was...

  11. Cytotoxicity of the coagulant Moringa oleifera lectin (cMoL) to B16-F10 melanoma cells.

    Science.gov (United States)

    de Andrade Luz, Luciana; Rossato, Franco Aparecido; Costa, Rute Alves Pereira E; Napoleão, Thiago Henrique; Paiva, Patrícia Maria Guedes; Coelho, Luana Cassandra Breitenbach Barroso

    2017-10-01

    Moringa oleifera seeds are used in alternative medicine to treat inflammation, tumors and bacterial and protozoan infections, for example. The seeds contain lectins, which are carbohydrate-binding proteins with several biological properties including cytotoxicity to cancer cells. In this work, we examined the cytotoxicity of the coagulant M. oleifera lectin (cMoL) on B16-F10 murine melanoma cells. cMoL cytotoxic effects were evaluated through trypan blue assay and flow cytometry analysis. Mitochondrial superoxide levels and activation of caspases 3, 8 and 9 were measured. cMoL (1.5-16μM) reduced viability and caused cell death of B16-F10 cells with an IC 50 of 9.72μM. Flow cytometry analysis indicated induction of necrosis and suggested the presence of cells in late apoptosis. Specificity for tumor cells was observed since death of normal human fibroblasts (GN) was not higher than 20% in treatments with cMoL from 1.5 to 16μM. Microscopy images revealed rounded shape and reduction of volume in B16-F10 cells treated with cMoL. cMoL increased mitochondrial ROS production and promoted caspases 3, 8 and 9 activation in B16-F10 cells, indicating the activation of apoptosis-related pathway. In conclusion, this study demonstrates that cMoL is cytotoxic to B16-F10 cells, which stimulates more investigation on the anticancer potential of this lectin. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Groups as a part of integrated treatment plans : Inpatient psychotherapy for outpatients?

    NARCIS (Netherlands)

    Staats, H

    2005-01-01

    Group psychotherapy in Germany is well established as part of an integrative treatment plan in inpatient treatment. Outpatient group psychotherapy, however, is conceptualized as a separate treatment option in competition with individual therapy. German guidelines for outpatient psychotherapy exclude

  13. Embeddings of SU/sup c/3 in unifying gauge groups

    International Nuclear Information System (INIS)

    Slansky, R.

    1978-01-01

    Hypothetical models that attempt to unify electromagnetic, weak, and strong interactions into a simple, compact gauge group G are discussed. The problem of embedding the strong group SU 3 /sup c/ in any larger simple group is solved, and a complete classification of theories where the color in some representation is restricted to 1/sup c/, 3/sup c/, and anti 3/sup c/ is given

  14. B-to-C Digital Marketing Plan for ONAR Studios

    OpenAIRE

    Juvonen, Mirjam

    2016-01-01

    Traditional marketing methods are losing their impact in this continuously more digital world. Most customers are online and businesses need to be there, too. Through a creative plan for digital marketing, businesses can gain an advantage over their competitors, which is highly needed especially in the extremely competitive fashion industry. The objective of this product-based thesis is to create a B-to-C digital marketing plan for the case company, ONAR Studios, a small Finnish fashion b...

  15. 12 CFR 16.16 - Effectiveness.

    Science.gov (United States)

    2010-01-01

    ... Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY SECURITIES OFFERING DISCLOSURE RULES § 16.16 Effectiveness. (a) Registration statements and amendments filed with the OCC pursuant to this part...) and (c)) and Commission Regulation C (17 CFR part 230, Regulation C—Registration). (b) The OCC will...

  16. Detection of forbidden Singlet-Triplet Transitions of 12C16O

    CSIR Research Space (South Africa)

    Steenkamp, CM

    2010-09-01

    Full Text Available Twenty rovibronic transitions of the e(v'=5)-X(v''=0) band of the 12C16O which experimental wavelengths were previously unavailable were recently detected by vr induced fluorescence excitation spectroscopy. The data is important in astrophysical...

  17. Dioctofimose em cães: 16 casos Dioctophymosis in dogs: 16 cases

    Directory of Open Access Journals (Sweden)

    Glaucia Denise Kommers

    1999-09-01

    Full Text Available No período de 1978 a 1996, de um total de 3.259 cães necropsiados, 16 (0,49% apresentaram parasitismo por Dioctophyma renale. Desses, 12 (75% eram cães de rua. Em 13 cães (81, 2%, um ou vários parasitas localizavam-se no rim direito. Em 3 casos (18,7%, o parasita foi observado na cavidade abdominal. Nos casos de parasitismo renal, observou-se acentuada atrofia do parênquima, transformando o rim numa bolsa fibrosa contendo o parasita em meio a exsudato necro-hemorrágico semilíquido. Foi observada hipertrofia renal compensatória contralateral em 5 casos. O ciclo evolutivo de D. renale é complexo e incompletamente entendido. Envolve um hospedeiro intermediário e hospedeiros paratênicos. A alta ocorrência da doença em cães de rua sugere que a infecção seja relacionada aos hábitos alimentares pouco seletivos desses animais.From 1978 to 1996, out of a total of 3,259 dogs necropsied, sixteen (0.49% were parasitized by Dioctophyma renale. Twelve of those (75% were stray dogs. Thirteen dogs (81.2% presented one or more specimens of D. renale in the right kidney. In three dogs (18.7%, the parasite was observed in the abdominal cavity. In those cases of renal parasitism, there was marked atrophy of the kidney which became a fibrous-walled bag within which the parasite was found imersed in a semiliquid necro-hemorrhagic exudate. In five cases, compensatory hypertrophy of the contralateral kidney was observed. The life cycle of D. renale is complex and not fully understood. It envolves intermediate and parathenic hosts. The high incidence of the disease in stray dog suggests that the infection is related to the poor selective feeding habits of this kind of dog.

  18. The 12C+12C → 8Begs+16Ogs reaction at Ecm=27 to 36 MeV

    International Nuclear Information System (INIS)

    Aliotta, M.; Lattuada, M.; Spitaleri, C.

    1996-01-01

    The 12 C + 12 C → 8 Be gs + 16 O gs reaction has been experimentally investigated at c.m. energies between 27 and 36 MeV. A resonance is present at 32.5 MeV, i.e. at the same energy of the resonance previously observed [1] in the 12 C(0 + 2 ) + 12 C(0 + 2 ) exit channel, but its width is about three times narrower. Moreover the data indicate an enhancement of the cross section at a c.m. energy close to 29 MeV. These results are discussed and compared to the predictions of the Band Crossing Model obtained for different exit channels of the 12 C + 12 C reaction. (orig.)

  19. Viscoelastic wormlike micelles formed by ionic liquid-type surfactant [C16imC8]Br towards template-assisted synthesis of CdS quantum dots.

    Science.gov (United States)

    Hu, Yimin; Han, Jie; Ge, Lingling; Guo, Rong

    2018-01-31

    In this paper, viscoelastic wormlike micelles consisting of cationic liquid-type surfactant, 1-hexadecyl-3-octyl imidazolium bromide ([C 16 imC 8 ]Br), water and different additives were utilized for the synthesis of CdS quantum dots. First, the influence of different additives, such as [Cd(NH 3 ) 6 ]Cl 2 and ethanethioamid (precursors for the synthesis of CdS quantum dots), and temperature on the viscoelasticity of the [C 16 imC 8 ]Br aqueous solution was studied by dynamic and steady rheology. Furthermore, the synthesized CdS quantum dots and their photoluminescence properties were characterized by transmission electron microscopy (TEM), UV-Vis absorption spectroscopy, X-ray diffraction (XRD) and energy-dispersive X-ray spectroscopy (EDX). In the end, the mechanism for the synthesis of CdS quantum dots in [C 16 imC 8 ]Br wormlike micelles is proposed.

  20. Fatigue performance of HFIR-irradiated Nimonic PE-16 at 4300C

    International Nuclear Information System (INIS)

    Grossbeck, M.L.; Liu, K.C.

    1983-01-01

    Nimonic PE-16 was irradiated in the HFIR to 6 to 9 dpa and 560 to 1000 at. ppM He at 430 0 C. Postirradiation fatigue tests revealed a reduction in fatigue life by about a factor of 10 at 430 0 C. In contrast to AISI type 316 stainless steel, no endurance limit was observed. All irradiated specimens exhibited some intergranular fracture with an increasing tendency toward cleavage-like intragranular fracture for low strain ranges

  1. Non commutative geometry methods for group C{sup *}-algebras

    Energy Technology Data Exchange (ETDEWEB)

    Diep, Do Ngoc

    1996-09-01

    This book is intended to provide a quick introduction to the subject. The exposition is scheduled in the sequence, as possible for more understanding for beginners. The author exposed a K-theoretic approach to study group C{sup *}-algebras: started in the elementary part, with one example of description of the structure of C{sup *}-algebra of the group of affine transformations of the real straight line, continued then for some special classes of solvable and nilpotent Lie groups. In the second advanced part, he introduced the main tools of the theory. In particular, the conception of multidimensional geometric quantization and the index of group C{sup *}-algebras were created and developed. (author). Refs.

  2. Constellation Mission Operation Working Group: ESMO Maneuver Planning Process Review

    Science.gov (United States)

    Moyer, Eric

    2015-01-01

    The Earth Science Mission Operation (ESMO) Project created an Independent Review Board to review our Conjunction Risk evaluation process and Maneuver Planning Process to identify improvements that safely manages mission conjunction risks, maintains ground track science requirements, and minimizes overall hours expended on High Interest Events (HIE). The Review Board is evaluating the current maneuver process which requires support by multiple groups. In the past year, there have been several changes to the processes although many prior and new concerns exist. This presentation will discuss maneuver process reviews and Board comments, ESMO assessment and path foward, ESMO future plans, recent changes and concerns.

  3. Anoctamin 9/TMEM16J is a cation channel activated by cAMP/PKA signal.

    Science.gov (United States)

    Kim, Hyungsup; Kim, Hyesu; Lee, Jesun; Lee, Byeongjun; Kim, Hee-Ryang; Jung, Jooyoung; Lee, Mi-Ock; Oh, Uhtaek

    2018-05-01

    Anoctamins (ANOs) are multifunctional membrane proteins that consist of 10 homologs. ANO1 (TMEM16A) and ANO2 (TMEM16B) are anion channels activated by intracellular calcium that meditate numerous physiological functions. ANO6 is a scramblase that redistributes phospholipids across the cell membrane. The other homologs are not well characterized. We found ANO9/TMEM16J is a cation channel activated by a cAMP-dependent protein kinase A (PKA). Intracellular cAMP-activated robust currents in whole cells expressing ANO9, which were inhibited by a PKA blocker. A cholera toxin that persistently stimulated adenylate cyclase activated ANO9 as did the application of PKA. The cAMP-induced ANO9 currents were permeable to cations. The cAMP-dependent ANO9 currents were augmented by intracellular Ca 2+ . Ano9 transcripts were predominant in the intestines. Human intestinal SW480 cells expressed high levels of Ano9 transcripts and showed PKA inhibitor-reversible cAMP-dependent currents. We conclude that ANO9 is a cation channel activated by a cAMP/PKA pathway and could play a role in intestine function. Copyright © 2017. Published by Elsevier Ltd.

  4. Elimination of the 12 C and 16 O in the elastic scattering of 14 C by polarized protons

    International Nuclear Information System (INIS)

    Avila A, O.L.; Ramirez T, J.J.; Murillo O, G.; Fernandez B, M.

    1991-04-01

    The study of the elastic scattering of 14 C for polarized protons it provides information on the nuclear structure of 15 N. In the Tandem accelerator of the Nuclear Center in collaboration with the University of Notre Dame is carrying out this study to energy between 5.0 and 9.0 MeV in steps of 10 keV. The measures of differential section and vectorial analyzer power are subjected to shift analysis of phase being able to determine the parameters of the excited levels of 15 N that are it angular momentum, parity, level width and elastic width. The details of this experiment are presented in the ACEL-9102 technical report while in this work it was discussed the way in that contributions of 12 C and 16 O are eliminated that are present as impurities in our target of 14 C. At small angles the elastic components of these impurities are shoveled with the elastic of 14 C. In the experiment carried out in the Nuclear Center were take measures of differential section for 6 angles; 35, 45, 55, 65, 145 and 165 using surface barrier detectors. It is observed that it exists shovels at 35, 45, 55 and 65 while at 145 and 165 the 12 C, the 14 C and the 16 O are totally separate. With the purpose of being able to subtract of the elastic of 14 C the proportion of 12 C, it was decided to bombard a target of 12 C leaving the same geometry that had been used to bombard 14 C. With this also carried out the reaction 12 C (p,p) 12 C between 5.0 and 9.0 MeV in steps of 50 keV. Starting from these spectra are the integration (yield) of the elastic of 12 C. (Author)

  5. Experimental measurement of 12C+16O fusion at stellar energies

    Science.gov (United States)

    Fang, X.; Tan, W. P.; Beard, M.; deBoer, R. J.; Gilardy, G.; Jung, H.; Liu, Q.; Lyons, S.; Robertson, D.; Setoodehnia, K.; Seymour, C.; Stech, E.; Vande Kolk, B.; Wiescher, M.; deSouza, R. T.; Hudan, S.; Singh, V.; Tang, X. D.; Uberseder, E.

    2017-10-01

    The total cross section of the 12C+16O fusion reaction has been measured at low energies to investigate the role of this reaction during late stellar evolution burning phases. A high-intensity oxygen beam, produced by the 5 MV pelletron accelerator at the University of Notre Dame, impinged on a thick, ultrapure graphite target. Protons and γ rays were simultaneously measured in the center-of-mass energy range from 3.64 to 5.01 MeV for singles and from 3.73 to 4.84 MeV for coincidence events, using silicon and Ge detectors. Statistical model calculations were employed to interpret the experimental results. The emergence of a new resonance-like broad structure and a decreasing trend in the S -factor data towards lower energies (opposite to previous data) are found for the 12C+16O fusion reaction. Based on these results the uncertainty range of the reaction rate within the temperature range of late stellar burning environments is discussed.

  6. Changes in HDL-c concentrations after 16 weeks of combined training in postmenopausal women: characteristics of positive and negative responders.

    Science.gov (United States)

    Diniz, Tiego A; Rossi, Fabricio E; Fortaleza, Ana Claudia Souza; Neves, Lucas Melo; Christofaro, Diego Giulliano Destro; Buonani, Camila; Lira, Fabio S; Campos, Eduardo Zapaterra; Prado, Wagner Luiz do; Freitas, Ismael Forte

    2018-01-01

    This study aimed to investigate the individual characteristics of body composition and metabolic profile that could explain interindividual variation in high-density lipoprotein cholesterol (HDL-c) concentrations in response to 16 weeks of combined strength plus aerobic (combined) training in postmenopausal women. The participants were divided into tertiles based on percentage of changes in HDL-c concentrations after combined training. Only women in the upper tertile (positive responders: Δ > 10.4%; n = 19) and lower tertile (negative responders: Δ < -1.4%; n = 19) were considered for analyses. The total body fat (BF), trunk fat (TF), android fat (AF), gynoid fat, and lean body mass were estimated by dual-energy X-ray absorptiometry. The metabolic profile - glucose, triacylglycerol, total cholesterol, HDL-c, low-density lipoprotein cholesterol, and very-low-density lipoprotein (VLDL) - were assessed. After 16 weeks, both positive and negative responders presented similar improvement in body composition, such as a decrease in percentage and kilograms of BF, TF, and AF, and increase in lean body mass (p value for time < 0.05). As expected, there was an effect of time and also a significant interaction (time vs. group) (p value < 0.001) in the improvement of HDL-c, with higher values for positive responders. Regarding metabolic profile, there were significant interactions (time vs. group) for triacylglycerol (p value = 0.032) and VLDL (p value = 0.027) concentrations, with lower values for positive responders. Our results suggests there is heterogeneity in combined training-induced HDL-c changes in postmenopausal women, and the positive responders were those who presented more pronounced decreases in triacylglycerol and VLDL concentrations.

  7. Transition plan: Project C-018H, 200-E Area Effluent Treatment Facility

    International Nuclear Information System (INIS)

    Connor, M.D.

    1994-01-01

    The purpose of this transition plan is to ensure an orderly transfer of project information to operations to satisfy Westinghouse Hanford Company (WHC) operational requirements and objectives, and ensure safe and efficient operation of Project C-018H, the 200-E Area Effluent Treatment Facility (ETF). This plan identifies the deliverables for Project C-018H upon completion of construction and turnover to WHC for operations, and includes acceptance criteria to objectively assess the adequacy of the contract deliverables in relation to present requirements. The scope of this plan includes a general discussion of the need for complete and accurate design basis documentation and design documents as project deliverables. This plan also proposes that a configuration management plan be prepared to protect and control the transferred design documents and reconstitute the design basis and design requirements, in the event that the deliverables and project documentation received from the contractor are less than adequate at turnover

  8. 75 FR 34571 - Group Health Plans and Health Insurance Coverage Rules Relating to Status as a Grandfathered...

    Science.gov (United States)

    2010-06-17

    ... Group Health Plans and Health Insurance Coverage Rules Relating to Status as a Grandfathered Health Plan... of Consumer Information and Insurance Oversight of the U.S. Department of Health and Human Services... health insurance coverage offered in connection with a group health plan under the Employee Retirement...

  9. Enhancing School Asthma Action Plans: Qualitative Results from Southeast Minnesota Beacon Stakeholder Groups

    Science.gov (United States)

    Egginton, Jason S.; Textor, Lauren; Knoebel, Erin; McWilliams, Deborah; Aleman, Marty; Yawn, Barbara

    2013-01-01

    Background: This study explores ways southeast Minnesota schools currently address asthma problems, identifies areas for improvement, and assesses the potential value of asthma action plans (AAPs) in schools. Methods: Focus groups were used to query stakeholder groups on asthma care in schools. Groups were held separately for elementary school…

  10. Association of body mass index and waist circumference with hypertension among school children in the age group of 5-16 years belonging to lower income group and middle income group in National Capital Territory of Delhi

    Directory of Open Access Journals (Sweden)

    Umesh Kapil

    2013-01-01

    Full Text Available Background and Objectives: Hypertension is one of the most common diseases world-wide and the prevalence in school-aged children appears to be increasing perhaps as a result of increased prevalence of obesity. Thus, the present study was planned to establish an association between body mass index (BMI and waist circumference (WC with hypertension amongst school children in the age group of 5-16 years belonging to lower income group (LIG and middle income group (MIG in National Capital Territory of Delhi. Materials and Methods: Population proportionate to size methodology was adopted to select 30 clusters/schools in each LIG and MIG category. About 170 children from each school were selected randomly with the help of random number tables. Anthropometric measurements of weight, height and WC and blood pressure measurements were taken by using standard methodology. Results: The prevalence of high systolic blood pressure (SBP in LIG and MIG school population was 2.8% and 4.1% respectively. Similarly, the prevalence of high diastolic blood pressure (DBP in LIG and MIG school population was 2.7% and 4.2%, respectively. Statistical positive correlation was observed between BMI and WC with SBP and DBP. Thus, it can be inferred that children with high WC and BMI are more likely to have hypertension.

  11. Regional Management Plan: Summary report

    International Nuclear Information System (INIS)

    Drobny, N.L.

    1986-01-01

    This summary report describes the results of a 16-month project to develop a Regional Management Plan for low-level radioactive waste management in a seven-state area. The seven states are Indiana, Iowa, Michigan, Minnesota, Missouri, Ohio, and Wisconsin. These states have formed the Midwest Interstate Low-Level Radioactive Waste Commission in accord with Congressional requirements established in 1980. What is low-level radioactive waste? Low-level radioactive waste results from the use of radioactive materials in the treatment of disease, the production of consumer goods and industrial products, and from the generation of electricity at nuclear power plants. Low-level wastes, which are a responsibility of the states, are grouped into three classes, A, B, and C; this classification scheme is prescribed by Federal Regulations and represents different degrees of hazard associated with different concentrations of radioactive materials. Class A wastes are the least hazardous. Classes B and C represent higher hazard classes. 14 refs., 13 figs., 9 tabs

  12. Experimental study of the E2 strength distribution in the 12C and 16O nuclei

    International Nuclear Information System (INIS)

    Buenerd, M.; California Univ., Berkeley; Gelbke, C.K.; Hendrie, D.L.; Mahoney, J.; Olmer, C.; Scott, D.K.

    1977-01-01

    The distribution of the E2 strength in 12 C and 16 O nuclei is investigated by inelastic scattering of 3 He. The giant quadrupole resonance is found to be splitted into several states in both nuclei and exhausts 31% and 37% of the quadrupole energy weighted sum rule (EWSR) in 12 C and 16 O respectively

  13. Use of a fragment of the tuf gene for phytoplasma 16Sr group/subgroup differentiation

    DEFF Research Database (Denmark)

    Contaldo, Nicoletta; Canel, Alessandro; Makarova, Olga

    2011-01-01

    The usefulness of RFLP analyses on a 435 bp fragment of the tuf gene for preliminary identification of phytoplasmas from a number of phytoplasma ribosomal groups and/or 'Candidatus. Phytoplasma' was verified. The strains employed belong to thirteen 16Sr DNA groups and 22 different subgroups...

  14. Functional evaluation of the role of C-type lectin domain family 16A at the chromosome 16p13 locus.

    Science.gov (United States)

    Zouk, H; D'Hennezel, E; Du, X; Ounissi-Benkalha, H; Piccirillo, C A; Polychronakos, C

    2014-03-01

    The type 1 diabetes-associated 16p13 locus contains the CLEC16A gene. Its preferential immune cell expression suggests involvement in autoimmunity. Given its elevated expression in dendritic and B cells - known professional antigen-presenting cells (APCs) - we hypothesize that C-type lectin domain family 16 member A (CLEC16A) may be involved in T cell co-stimulation and consequent activation and proliferation. We also sought to identify CLEC16A's subcellular localization. The effect of the CLEC16A knock-down (KD) on B cell co-stimulation and activation of T cells was tested in human lymphoblastoid cell lines (LCLs) by co-culture with CD4(+) T cells. T cell activation and proliferation were determined by flow-cytometric analysis of CD69 and CD25 expression and carboxyfluorescein succinimidyl ester (CFSE) dilution, respectively. CLEC16A subcellular localization in K562 cells was examined by immunofluorescence. We show that the CLEC16A KD did not affect the tested indices of lymphoblastoid cell line (LCL) APC capacity. Additionally, the percentage of activated T cells following LCL co-culture was not affected significantly by the CLEC16A KD. T cells co-cultured with KD or control LCLs also exhibited similar cell division profiles. CLEC16A co-localized with an endoplasmic reticulum (ER) marker, suggesting that it may be an ER protein. In conclusion, CLEC16A may not be involved in T cell co-stimulation. Additional studies on CLEC16A, accounting for its ER localization, are needed to uncover its biological role. © 2013 British Society for Immunology.

  15. 26 CFR 1.404(c)-1 - Certain negotiated plans; effect of section 404(c).

    Science.gov (United States)

    2010-04-01

    ... TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc... such an agreement in the bituminous coal industry, a similar trust established about the same time in the anthracite coal industry would be covered by this provision. (c) If any such trust becomes...

  16. 75 FR 37242 - Requirements for Group Health Plans and Health Insurance Issuers Under the Patient Protection and...

    Science.gov (United States)

    2010-06-28

    ... Requirements for Group Health Plans and Health Insurance Issuers Under the Patient Protection and Affordable... Labor and the Office of Consumer Information and Insurance Oversight of the U.S. Department of Health... guidance to employers, group health plans, and health insurance issuers providing group health insurance...

  17. 76 FR 46621 - Group Health Plans and Health Insurance Issuers Relating to Coverage of Preventive Services Under...

    Science.gov (United States)

    2011-08-03

    ... to the interim final regulations implementing the rules for group health plans and health insurance... dates. These interim final regulations generally apply to group health plans and group health insurance... from HHS on private health insurance for consumers can be found on the Centers for Medicare & Medicaid...

  18. CH2M Hill Hanford Group Inc (CHG) Information Resource Management (IRM) Strategic Plan

    Energy Technology Data Exchange (ETDEWEB)

    NELSON, R.L.

    2000-05-08

    The CH2M Hill Hanford Group, Inc., Information Resource Management Strategic Plan is the top-level planning document for applying information and information resource management to achieve the CHG mission for the management of the River Protection Project

  19. CH2M Hill Hanford Group Inc (CHG) Information Resource Management (IRM) Strategic Plan

    International Nuclear Information System (INIS)

    NELSON, R.L.

    2000-01-01

    The CH2M Hill Hanford Group, Inc., Information Resource Management Strategic Plan is the top-level planning document for applying information and information resource management to achieve the CHG mission for the management of the River Protection Project

  20. [Hepatitis C in women planning a pregnancy: current opinions].

    Science.gov (United States)

    Langlet, P; Lasser, L; Sidi, B

    2005-01-01

    Chronic hepatitis C (VHC) is a worldwide public health issue. The mother-to-child transmission could be the main cause of hepatitis C infection in children. Despite the risk of histological injuries, chronic hepatitis C is not a contra-indication to pregnancy. In patients with VHC, there is no evidence that the outcome could be modified. In co-infected patients (VIH-VHC), a caesarean should be proposed taking into account the significant risk of mother-to-child transmission. Breast-feeding is not contra-indicated. Systematic screening of VHC, discussed in this article, could be proposed in woman planning a pregnancy.

  1. Treating Social Anxiety in Adolescents: Ten Group Therapy Lesson Plans

    Science.gov (United States)

    Mazur-Elmer, Alison; McBride, Dawn

    2009-01-01

    This project provides a comprehensive overview of the research literature on social anxiety disorder (SAD) in adolescents and concludes by offering a set of 10 group therapy lesson plans for SAD that therapists can use in their practice. The overview includes a description of social anxiety disorder and highlights various theories of anxiety. The…

  2. [Effects of oral interventions on carotid artery in rats with chronic periodontitis for the detection of Porphyromonas gingivalis and the expression of C-reactive protein].

    Science.gov (United States)

    Xiuyun, Ren; Chong, Wang; Xin, Liu; Hao, Li; Qianhui, Ma; Mu, Lin; Xuexue, Shi; Jinhua, Gao

    2017-04-01

    This study aimed to establish a SD rat model of chronic periodontitis (CP) merged with hyperlipidemia (HL), perform periodontal treatment, detect the expression of partial C-reactive protein (CRP) and Porphyromonas gingivalis (P. gingivalis) in the rat carotid artery, and explore the relationship between periodontitis and atherosclerosis. SD rats were randomly divided into three groups: control group (A), HL group (B), and CP+HL group (C). Group C rats were divided into natural process group (C1), scaling and root planning group (C2), and tooth extraction group (C3). Group C2 rats were randomly divided into C2-1 (scaling and root planning group) and C2-2 (scaling and root planning+minocyline+systemic antibiotics group). Group C3 rats were randomly divided into C3-1 (tooth extraction group) and C3-2 (tooth extraction+systemic antibiotic group). One rat from group B was randomly selected and sacrificed after 15 weeks. Subsequently, the carotid vascular tissue was collected for oil red O staining. Modeling was successful when foam cell formation was observed. Periodontal treatments were conducted twice, and euthanasia was performed after the experiment. Moreover, double-carotid artery bifurcation was carried out to detect the expression of CRP and P. gingivalis. Immunohistochemical and 16sRNA semiquantitative methods were used to detect the CRP expression and the relative contents of P. gingivalis, respectively. Immunohistochemical results showed that the CRP-positive expression in groups B and C was significantly higher than that in group A (PC rats were significantly lower than that in group C1 (PC2-2 was the lowest among the groups (PC1 was the highest and significantly higher than that in groups A and B (PC2-1, C2-2, C3-1, and C3-2 were significantly lower than that in group C1 (PC3-2 was the lowest (Pperiodontal basic treatment and tooth extraction, could improve carotid artery lesions. The basic treatment with local and systemic anti-inflammatory drugs exerts

  3. Effects of methyl substitution on the auto-ignition of C16 alkanes

    KAUST Repository

    Lapuerta, Magín

    2015-12-18

    The auto-ignition quality of diesel fuels, quantified by their cetane number or derived cetane number (DCN), is a critical design property to consider when producing and upgrading synthetic paraffinic fuels. It is well known that auto-ignition characteristics of paraffinic fuels depend on their degree of methyl substitution. However, there remains a need to study the governing chemical functionalities contributing to such ignition characteristics, especially in the case of methyl substitutions, which have not been studied in detail. In this work, the auto-ignition of 2,6,10-trimethyltridecane has been compared with the reference hydrocarbons used for cetane number determination, i.e. n-hexadecane and heptamethylnonane, all of them being C16 isomers. Results from a constant-volume combustion chamber under different pressure and temperature initial conditions showed that the ignition delay time for both cool flame and main combustion events increased less from n-hexadecane to trimethyltridecane than from trimethyltridecane to heptamethylnonane. Additional experimental results from blends of these hydrocarbons, together with kinetic modelling, showed that auto-ignition times and combustion rates were correlated to the concentration of the functional groups indicative of methyl substitution, although not in a linear manner. When the concentration of these functional groups decreased, the first stage OH radical concentration increased and ignition delay times decreased, whereas when their concentration increased, H2O2 production was slower and ignition was retarded. Contrary to the ignition delay times, DCN was correlated linearly with functional groups, thus homogenizing the range of values and clarifying the differences between fuels.

  4. Effects of methyl substitution on the auto-ignition of C16 alkanes

    KAUST Repository

    Lapuerta, Magí n; Herná ndez, Juan J.; Sarathy, Mani

    2015-01-01

    The auto-ignition quality of diesel fuels, quantified by their cetane number or derived cetane number (DCN), is a critical design property to consider when producing and upgrading synthetic paraffinic fuels. It is well known that auto-ignition characteristics of paraffinic fuels depend on their degree of methyl substitution. However, there remains a need to study the governing chemical functionalities contributing to such ignition characteristics, especially in the case of methyl substitutions, which have not been studied in detail. In this work, the auto-ignition of 2,6,10-trimethyltridecane has been compared with the reference hydrocarbons used for cetane number determination, i.e. n-hexadecane and heptamethylnonane, all of them being C16 isomers. Results from a constant-volume combustion chamber under different pressure and temperature initial conditions showed that the ignition delay time for both cool flame and main combustion events increased less from n-hexadecane to trimethyltridecane than from trimethyltridecane to heptamethylnonane. Additional experimental results from blends of these hydrocarbons, together with kinetic modelling, showed that auto-ignition times and combustion rates were correlated to the concentration of the functional groups indicative of methyl substitution, although not in a linear manner. When the concentration of these functional groups decreased, the first stage OH radical concentration increased and ignition delay times decreased, whereas when their concentration increased, H2O2 production was slower and ignition was retarded. Contrary to the ignition delay times, DCN was correlated linearly with functional groups, thus homogenizing the range of values and clarifying the differences between fuels.

  5. CH2M Hill Hanford Group Inc (CHG) Information Resource Management (IRM) Strategic Plan

    Energy Technology Data Exchange (ETDEWEB)

    NELSON, R.L.

    2000-06-06

    The CH2M HILL Hanford Group, Inc. (CHG), Information Resource Management Strategic Plan is the top-level planning document for applying information and information resource management to achieve the CHG mission for the management of the River Protection Project waste tank farm.

  6. CH2M Hill Hanford Group Inc (CHG) Information Resource Management (IRM) Strategic Plan

    International Nuclear Information System (INIS)

    NELSON, R.L.

    2000-01-01

    The CH2M HILL Hanford Group, Inc. (CHG), Information Resource Management Strategic Plan is the top-level planning document for applying information and information resource management to achieve the CHG mission for the management of the River Protection Project waste tank farm

  7. Measurements and modeling of 16O12C17O spectroscopic parameters at 2 μm

    Science.gov (United States)

    Jacquemart, David; Sung, Keeyoon; Coleman, Max; Crawford, Timothy; Brown, Linda R.; Mantz, Arlan W.; Smith, Mary Ann H.

    2017-12-01

    The lack of spectroscopic measurements for rare CO2 isotopologues was the main motivation of this work. In our present study we report line intensity measurements for 16O12C17O made with a high resolution Fourier transform spectrometer (Bruker IFS-125HR) and a 21 m path cryogenic Herriott cell at Jet Propulsion Laboratory. For this, a 17O-enriched CO2 gas sample was used, which comes as a mixture of primary and several minor CO2 isotopologues. The mole fraction of the 16O12C17O isotopologue in the mixture was determined to be 0.3991 by mass spectrometry from a Stable Isotope Ratio Mass Spectrometer (SIRMS) under stochastic distribution assumption at thermal equilibrium. Since the collisional narrowing effect was observed, the Rautian molecular line shape profile was systematically adopted instead of the Voigt profile. Absolute line positions were also investigated by performing a wavenumber calibration based on CO, HCl and a few well-known 16O12C16O transitions. Finally, around 1000 transitions were studied between 4604 and 5126 cm-1 involving 15 bands of the 16O12C17O isotopologue. All the measured line intensities were renormalized to be the values for 100% pure isotopologue sample. Transition dipole moments and Herman-Wallis factors were derived enabling a global comparison with theoretical calculations and predictions for the 15 bands of the 16O12C17O isotopologue. For the measured line positions, the absolute accuracy is around 2×10-4 cm-1. The accuracies of retrieved line intensities are 2 - 5% for five cold and two hot bands, and 6-30% for eight other weaker hot bands. Results from this work were in a good agreement with HITRAN 2012 for positions, but showed rather significant discrepancies for line intensities. An extensive line list was generated from new experimental measurements in order to improve and validate spectroscopic knowledge of 12C16O17O isotopologue in support of atmospheric remote sensing for the Earth (e.g., OCO-2 mission), Mars and Venus.

  8. Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism.

    Science.gov (United States)

    Philippi, A; Roschmann, E; Tores, F; Lindenbaum, P; Benajou, A; Germain-Leclerc, L; Marcaillou, C; Fontaine, K; Vanpeene, M; Roy, S; Maillard, S; Decaulne, V; Saraiva, J P; Brooks, P; Rousseau, F; Hager, J

    2005-10-01

    Autism is a developmental disorder characterized by impairments in social interaction and communication associated with repetitive patterns of interest or behavior. Autism is highly influenced by genetic factors. Genome-wide linkage and candidate gene association approaches have been used to try and identify autism genes. A few loci have repeatedly been reported linked to autism. Several groups reported evidence for linkage to a region on chromosome 16p. We have applied a direct physical identity-by-descent (IBD) mapping approach to perform a high-density (0.85 megabases) genome-wide linkage scan in 116 families from the AGRE collection. Our results confirm linkage to a region on chromosome 16p with autism. High-resolution single-nucleotide polymorphism (SNP) genotyping and analysis of this region show that haplotypes in the protein kinase c-beta gene are strongly associated with autism. An independent replication of the association in a second set of 167 trio families with autism confirmed our initial findings. Overall, our data provide evidence that the PRKCB1 gene on chromosome 16p may be involved in the etiology of autism.

  9. Command, Control, Communication, Computers and Information Technology (C4&IT). Strategic Plan, FY2008 - 2012

    National Research Council Canada - National Science Library

    2008-01-01

    ...&IT)/CG-6, Chief Information Officer (CIO), for the Coast Guard publishes this C4&IT Strategic Plan. The purpose of this plan is to provide a unifying strategy to better integrate and synchronize Coast Guard C4...

  10. Project management plan for Reactor 105-C Interim Safe Storage project

    International Nuclear Information System (INIS)

    Plagge, H.A.

    1996-09-01

    Reactor 105-C (located on the Hanford Site in Richland, Washington) will be placed into an interim safe storage condition such that (1) interim inspection can be limited to a 5-year frequency; (2) containment ensures that releases to the environmental are not credible under design basis conditions; and (3) final safe storage configuration shall not preclude or significantly increase the cost for any decommissioning alternatives for the reactor assembly.This project management plan establishes plans, organizational responsibilities, control systems, and procedures for managing the execution of Reactor 105-C interim safe storage activities to meet programmatic requirements within authorized funding and approved schedules

  11. Charge state distribution of 16O from the 4He(12C,16O)γ reaction of astrophysical interest studied both experimentally and theoretically

    International Nuclear Information System (INIS)

    Liu, Shengjin; Sakurai, Makoto; Sagara, Kenshi; Teranishi, Takashi; Fujita, Kunihiro; Yamaguchi, Hiroyuki; Matsuda, Sayaka; Mitsuzumi, Tatsuki; Iwazaki, Makoto; Rosary, Mariya T.; Kato, Daiji; Tolstikhina, I.Yu.

    2014-01-01

    In astrophysics, 4 He( 12 C, 16 O)γ reaction places an important role. At Kyushu University Tandem accelerator Laboratory (KUTL), the measurement of 4 He( 12 C, 16 O)γ cross section is in progress in the energy range of astrophysical nuclear reaction. Since the charge state of product 16 O ions after passing through the gas target is spread and only one charge state can be measured at terminal detector, it is necessary to know the charge state distribution of 16 O ions passing through the He gas target precisely. Here, we report the charge state distribution of the 16 O recoils both experimentally and theoretically. Experimentally, we measured the equilibrium charge state distribution of 16 O ions in the windowless helium gas target with the beam energy of primary 16 O ions at 7.2, 4.5, and 3.45 MeV at KUTL. The measured results showed a Gaussian distribution for the charge state fraction. Theoretically, we proposed a framework for the charge state distribution study. Charge state distribution was computed by solving a set of differential equations including a series of charge exchange cross sections. For the ionization cross section, plane-wave Born approximation was applied and modified by taking target atomic screening as a function of momentum transfer into account. For the capture cross section, continuum distorted wave approximation was applied and the influence of the gas target density was taken into account in the process of electron capture. Using above charge exchange cross sections, the charge state evolution was simulated. According to the equilibrium distribution, we compared the theoretical calculation to the experimental data. After taking into account the density effects in the charge exchange process, the theoretical charge state distributions shows a good agreement with the experimental data. Both experimental and theoretical results are useful to understand the charge fraction of recoil oxygen created via 4 He( 12 C, 16 O)γ reaction

  12. Record of the third meeting of sub-group A, Tokyo, 15-16 May 1978

    International Nuclear Information System (INIS)

    1978-05-01

    The items discussed include reports on the studies on the requirements for reprocessing (incl. discussion of NEA documents), national plans for reprocessing, base case (reprocessing plant), regional differences in energy supplies, and identification of criteria, and the report by the Co-Chairmen to Group 4

  13. 75 FR 41726 - Interim Final Rules for Group Health Plans and Health Insurance Issuers Relating to Coverage of...

    Science.gov (United States)

    2010-07-19

    ... Health Plans and Health Insurance Issuers Relating to Coverage of Preventive Services Under the Patient... and health insurance coverage in the group and individual markets under provisions of the Patient... plans and group health insurance issuers for plan years beginning on or after September 23, 2010. These...

  14. Decennial plan of expansion 1994-2003

    International Nuclear Information System (INIS)

    1993-12-01

    The Decennial Plan of Expansion 1994-2003 of Electric sector reproduces the results of the studies occurred during the planning cycle of 1992/93 from the Coordinator Groups of the Electric System Planning. Based in the market forecasting, economic-financier and time for finishing the the works, the Decennial Plan of Expansion presents the schedule of the main generation and transmission works for the next ten years, the annual spend in generation, transmission and distribution, the costs of expansion and the evaluation of attending conditions in electric system in Brazil. (C.G.C.)

  15. The SOLAR-C Mission: Plan B Payload Concept

    Science.gov (United States)

    Shimizu, T.; Sakao, T.; Katsukawa, Y.; Group, J. S. W.

    2012-08-01

    The telescope concepts for the SOLAR-C Plan B mission as of the time of the Hinode-3 meeting were briefly presented for having comments from the international solar physics community. The telescope candidates are 1) near IR-visible-UV telescope with 1.5m aperture and enhanced spectro-polarimetric capability, 2) UV/EUV high throughput spectrometer, and 3) next generation X-ray telescope.

  16. The Power of the Government: China's Family Planning Leading. Group and the Fertility Decline since 1970

    OpenAIRE

    Chen, Yi; Huang, Yingfei

    2018-01-01

    China introduced its world-famous One-Child Policy in 1979. However, its fertility appears to have declined even faster in the early 1970s than it did after 1979. In this study, we highlight the importance of the Family Planning Leading Group in understanding the fertility decline since the early 1970s. In 1970, provinces gradually established an institution named the Family Planning Leading Group to facilitate the restoration of family planning, which had previously been interrupted by the o...

  17. Adding exercise to rosuvastatin treatment: influence on C-reactive protein, monocyte toll-like receptor 4 expression, and inflammatory monocyte (CD14+CD16+) population.

    Science.gov (United States)

    Coen, Paul M; Flynn, Michael G; Markofski, Melissa M; Pence, Brandt D; Hannemann, Robert E

    2010-12-01

    Statin treatment and exercise training can reduce markers of inflammation when administered separately. The purpose of this study was to determine the effect of rosuvastatin treatment and the addition of exercise training on circulating markers of inflammation including C-reactive protein (CRP), monocyte toll-like receptor 4 (TLR4) expression, and CD14+CD16+ monocyte population size. Thirty-three hypercholesterolemic and physically inactive subjects were randomly assigned to rosuvastatin (R) or rosuvastatin/exercise (RE) groups. A third group of physically active hypercholesterolemic subjects served as a control (AC). The R and RE groups received rosuvastatin treatment (10 mg/d) for 20 weeks. From week 10 to week 20, the RE group also participated in an exercise training program (3d/wk). Measurements were made at baseline (Pre), week 10 (Mid), and week 20 (Post), and included TLR4 expression on CD14+ monocytes and CD14+CD16+ monocyte population size as determined by 3-color flow cytometry. Serum CRP was quantified by enzyme-linked immunosorbent assay. TLR4 expression on CD14+ monocytes was higher in the R group at week 20. When treatment groups (R and RE) were combined, serum CRP was lower across time. Furthermore, serum CRP and inflammatory monocyte population size were lower in the RE group compared with the R group at the Post time point. When all groups (R, RE, and AC) were combined, TLR4 expression was greater on inflammatory monocytes (CD14+CD16+) compared with classic monocytes (CD14+CD16⁻) at all time points. In conclusion, rosuvastatin may influence monocyte inflammatory response by increasing TLR4 expression on circulating monocytes. The addition of exercise training to rosuvastatin treatment further lowered CRP and reduced the size of the inflammatory monocyte population, suggesting an additive anti-inflammatory effect of exercise. Copyright © 2010 Elsevier Inc. All rights reserved.

  18. Budget model can aid group practice planning.

    Science.gov (United States)

    Bender, A D

    1991-12-01

    A medical practice can enhance its planning by developing a budgetary model to test effects of planning assumptions on its profitability and cash requirements. A model focusing on patient visits, payment mix, patient mix, and fee and payment schedules can help assess effects of proposed decisions. A planning model is not a substitute for planning but should complement a plan that includes mission, goals, values, strategic issues, and different outcomes.

  19. Condition-based dynamic maintenance operations planning and grouping. Application to commercial heavy vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Bouvard, K., E-mail: keomany.bouvard@volvo.co [Volvo Technology, 99 route de Lyon, 69806 Saint Priest cedex (France); Laboratoire d' Automatique de Genie Informatique et Signal - FRE3303 - Polytech' Lille, 59655 Villeneuve d' Ascq (France); Artus, S., E-mail: samuel.artus@volvo.co [Volvo Technology, 99 route de Lyon, 69806 Saint Priest cedex (France); Berenguer, C., E-mail: christophe.berenguer@utt.f [Universite de technologie de Troyes - Institut Charles Delaunay and UMR CNRS 6279 - 12, rue Marie Curie, BP2060, 10010 Troyes cedex (France); Cocquempot, V., E-mail: vincent.cocquempot@univ-lille1.f [Laboratoire d' Automatique de Genie Informatique et Signal - FRE3303 - Polytech' Lille, 59655 Villeneuve d' Ascq (France)

    2011-06-15

    This paper aims at presenting a method to optimize the maintenance planning for a commercial heavy vehicle. Such a vehicle may be considered as a multi-components system. Grouping maintenance operations related to each component reduces the global maintenance cost of the system. Classically, the optimization problem is solved using a priori reliability characteristics of components. Two types of methods may be used, i.e. static or dynamic methods. Static methods provide a fixed maintenance planning, whereas dynamic methods redefine the groups of maintenance operations at each decision time. Dynamic procedures can incorporate component information such as component states or detected failures. For deteriorating systems, reliability characteristics of each component may be estimated thanks to deterioration models and may be updated when a degradation measure is available. This additional information on degradation features allows to better follow the real state of each component and to improve the maintenance planning.

  20. Efficacy of adjunctive mitomycin C in transcanalicular diode laser dacryocystorhinostomy in different age groups.

    Science.gov (United States)

    Kar, Taner; Yildirim, Yildiray; Topal, Tuncay; Çolakoğlu, Kadir; Ünal, Melih Hamdi

    2016-01-01

    To evaluate the efficacy of adjunctive mitomycin C (MMC) in transcanalicular multidiode laser dacryocystorhinostomy (TCL-DCR) in different age groups. Ninety-six eyes of 96 patients who underwent TCL-DCR for the treatment of nasolacrimal duct obstruction were included in this retrospective, comparative study. Patients were divided into 4 groups based on age and intraoperative use of MMC: group 1, TCL-DCR without MMC in the 20- to 44-year age group; group 2, TCL-DCR with MMC in the 20- to 44-year age group; group 3, TCL-DCR without MMC in the 45- to 76-year age group; group 4, TCL-DCR with MMC in the 45- to 76-year age group. The postoperative evaluation consisted of calculating and comparing the success rates between groups. Success rates at the final visit were 50% for group 1, 66.66% for group 2, 79.16% for group 3, and 84.61% for group 4. The differences between group 1 and group 4, and group 1 and group 3, were significant (p = 0.01 and p = 0.038, respectively). Logistic regression showed that age group had significant effect on success rate (p = 0.013). However, use of MMC had no significant effect on success rate (p = 0.23). The success rates of the TCL-DCR with MMC application were found to be higher than those of TCL-DCR without MMC in different age groups. However, the differences did not reach statistical significance. In addition, our study demonstrated that age may be a significant factor influencing the surgical outcome of TCL-DCR.

  1. Estudo de p27, p21, p16 em epitélio escamoso normal, papiloma escamoso e carcinoma de células escamosas da cavidade oral Comparative analysis of the immunohistochemistry expression of p27, p21WAF/Cip1, and p16INK4a in oral normal epithelium, squamous papilloma and squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Ana Beatriz Piazza Queiroz

    2009-12-01

    Full Text Available INTRODUÇÃO E OBJETIVO: O tipo de câncer oral mais frequente é o carcinoma de células escamosas, que corresponde a 95% dos casos(9. O papiloma escamoso oral é uma neoplasia benigna normalmente associada à infecção pelo papilomavírus humano (HPV(21. A análise da literatura mostra alterações nos genes reguladores do ciclo celular p27, p21WAF/Cip1 e p16INK4a, porém sem uma definição de seus papéis na carcinogênese oral. O objetivo foi caracterizar imuno-histoquimicamente p27, p21WAF/Cip1 e p16NK4a em epitélio escamoso normal, papilomas escamosos e carcinomas de células escamosas da cavidade oral. MÉTODOS: Imuno-histoquímica para p27, p21WAF/Cip1 e p16NK4a em 32 casos de epitélio escamoso normal, 30 casos de papiloma escamoso e 34 de carcinoma de células escamosas da cavidade oral. RESULTADOS: p27: 97,06% dos casos de carcinoma de células escamosas apresentaram imunopositividade focal. O grupo papiloma escamoso apresentou 33,33% e o grupo controle, 18,75%. p21WAF/Cip1: 100% de imunopositividade focal tanto no grupo controle como no grupo carcinoma de células escamosas, e 90% no grupo papiloma escamoso. p16INK4a: 100% de imunopositividade focal para os grupos controle e papiloma escamoso, e 94% para o grupo carcinoma de células escamosas. CONCLUSÃO: Imuno-histoquimicamente demonstrou-se diferença significativa para p27 quando feita comparação dos grupos controle e papiloma escamoso com o grupo carcinoma de células escamosas. O p21WAF/Cip1 não demonstrou poder de diferenciar os grupos analisados. O p16INK4a apresentou imunopositividade difusa em uma minoria dos casos do grupo carcinoma de células escamosas. O grupo papiloma escamoso se comportou de maneira similar ao grupo controle em relação aos três marcadores.INTRODUCTION: The most frequent type of oral cancer is the squamous cell carcinoma, which corresponds to 95% of the cases(9.The oral squamous papilloma is a benign neoplasia, commonly associated with

  2. Review and evaluation of TDI diesel generator owner's group program plan

    International Nuclear Information System (INIS)

    1984-06-01

    This report documents a review, performed by the Pacific Northwest Laboratory (PNL), of the Transamerica Delaval, Inc. (TDI) Diesel Generator Owner's Group Program Plan. This report was prepared as part of the technical support PNL is providing to the US Nuclear Regulatory Commission (NRC), Division of Licensing, on matters pertaining to the reliability of TDI diesel generators as emergency power sources for safety-related nuclear systems. The report presents the comments and conclusions reached by PNL, with the advice and counsel of five diesel engine consultants, on the principal elements of the Owners' Group Plan: Generic Problem Resolution, Design Review/Quality Revalidation, and Engine Testing and Inspection. Also included are PNL's comments on the related issues of Surveillance and Maintenance, and Administrative Controls. The conclusions drawn from PNL's evaluation of these issues form the basis for two additional topics addressed in the report: Critical Elements Required to Establish Diesel Engine Operability and Reliability, and Considerations for Interim Licensing

  3. Efecto de fertilizantes y herbicidas sobre el crecimiento in vitro de Azospirillum brasilense C16

    OpenAIRE

    Romero-Perdomo, Felipe; Criollo Campos, Paola Jimena; Rodríguez, Andrea Jineth; Rusinque, Mauricio Camelo; Bonilla Buitrago, Ruth Rebeca

    2015-01-01

    El objetivo del presente estudio fue evaluar la influencia de fertilizantes (urea, fosfato diamónico y cloruro de potasio) y herbicidas (glifosato y 2,4-D) sobre la viabilidad de A. brasilense C16. Dicha viabilidad fue cuantificada en tres concentraciones de cada agroquímico, en un medio mínimo de sal, a las 0, 12 y 24 horas de crecimiento. Los resultados demostraron que el tipo de agroquímico, su concentración y el tiempo de exposición influyeron sobre C16 (p

  4. Management response plan for the Chemical Safety Vulnerability Working Group report. Volume 2

    International Nuclear Information System (INIS)

    1994-09-01

    The Chemical Safety Vulnerability (CSV) Working Group was established to identify adverse conditions involving hazardous chemicals at DOE facilities that might result in fires or explosions, release of hazardous chemicals to the environment, or exposure of workers or the public to chemicals. A CSV Review was conducted in 146 facilities at 29 sites. Eight generic vulnerabilities were documented related to: abandoned chemicals and chemical residuals; past chemical spills and ground releases; characterization of legacy chemicals and wastes; disposition of legacy chemicals; storage facilities and conditions; condition of facilities and support systems; unanalyzed and unaddressed hazards; and inventory control and tracking. Weaknesses in five programmatic areas were also identified related to: management commitment and planning; chemical safety management programs; aging facilities that continue to operate; nonoperating facilities awaiting deactivation; and resource allocations. To address the facility-specific and site-specific vulnerabilities, responsible DOE and site-contractor line organizations have developed initial site response plans. These plans, presented as Volume 2 of this Management Response Plan, describe the actions needed to mitigate or eliminate the facility- and site-specific vulnerabilities identified by the CSV Working Group field verification teams. Initial site response plans are described for: Brookhaven National Lab., Hanford Site, Idaho National Engineering Lab., Lawrence Livermore National Lab., Los Alamos National Lab., Oak Ridge Reservation, Rocky Flats Plant, Sandia National Laboratories, and Savannah River Site

  5. Effects of planned group interactions on the social adaptation of individuals with an intestinal stoma: a quantitative study.

    Science.gov (United States)

    Karabulut, Hatice K; Dinç, Leyla; Karadag, Ayişe

    2014-10-01

    To investigate the effects of a planned group interaction method on the social adjustment of individuals with an intestinal stoma. Individuals with a stoma often experience physiological, psychological and social problems that affect their social adaptation. Quasi-experimental. The population included ileostomy and colostomy patients registered at the Gazi University Health Research and Implementation Centre Stoma therapy Unit between September 2011-June 2012. They were assigned to experimental (n = 23) and control (n = 27) groups based on their willingness to attend planned group interaction meetings. Experimental group members participated in the 'planned group interaction method' for six weeks. Control group members only received routine care services. Weekly group interaction meetings lasted for average of 90 minutes. The Ostomy Adjustment Inventory and Psychosocial Adjustment to Illness Scale-Self-Report Scale were administered to experimental group members on three occasions: prior to the first group meeting, after the six-week meeting process ended and during the first month after group meetings ended. Control group evaluations were conducted simultaneously. Experimental group members' ostomy adjustment mean scores after planned group interaction meetings gradually increased. No changes occurred in the control group's average scores. The experimental and control groups' average psychosocial adjustment scores eventually changed and showed a tendency towards adjustment. Experimental group members aged 51-60 and 61-70, who were married, had primary and higher education, had permanent stomas, had stomas for periods between 12 months or less and 61 months and longer and had sufficient stoma care knowledge demonstrated higher adjustment values (p stoma care and daily life. Planned group interactions effectively enhanced the social adjustment of patients with a stoma. Group interaction methods should be included in nursing care practices for individuals with a

  6. Ionic fragmentation of a natural product, limonene (C10H16), following core [C 1s] photoionization

    International Nuclear Information System (INIS)

    Castilho, R.B. de; Nunez, C.V.; Coutinho, L.H.; Lago, A.F.; Bernini, R.B.; Souza, G.G.B. de

    2007-01-01

    Photoionization of the limonene [C 10 H 16 ] molecule was studied for the first time following C 1s ionization, using synchrotron radiation and time-of-fight mass spectrometry. As a reference for further analysis of the photon induced fragmentation of the limonene molecule, the He(I) mass spectrum was also obtained. Previously unreported singly charged species have been observed at 310 eV: H + , C + , CH + , CH 2 + , CH 3 + . A close similarity has been observed between the high photon energy mass spectrum and the standard electron impact mass spectrum of limonene, obtained at 70 eV. In particular, the base peak [C 5 H 8 + , m/q = 68], known to result from a Retro Diels-Alder reaction, remains the same in both cases. Approximate values for the mean kinetic energy were determined for all ionic species

  7. 21 CFR 111.16 - What are the requirements under this subpart C for written procedures?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false What are the requirements under this subpart C for written procedures? 111.16 Section 111.16 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CURRENT GOOD MANUFACTURING PRACTICE IN...

  8. 16 CFR Appendix C to Part 436 - Sample Item 20(2) Table-Transfers of Franchised Outlets

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Sample Item 20(2) Table-Transfers of Franchised Outlets C Appendix C to Part 436 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES DISCLOSURE REQUIREMENTS AND PROHIBITIONS CONCERNING FRANCHISING Pt. 436, App. C Appendix C to Part...

  9. New experimental investigation of cluster structures in 10 Be and 16 C neutron-rich nuclei

    Science.gov (United States)

    Dell'Aquila, L.; Acosta, D.; Auditore, L.; Cardella, G.; De Filippo, E.; De Luca, S.; Francalanza, L.; Gnoffo, B.; Lanzalone, G.; Lombardo, I.; Martorana, N. S.; Norella, S.; Pagano, A.; Pagano, E. V.; Papa, M.; Pirrone, S.; Politi, G.; Quattrocchi, L.; Rizzo, F.; Russotto, P.; Trifirò, A.; Trimarchi, M.; Verde, G.; Vigilante, M.

    2017-11-01

    The existence of cluster structures in ^{10} Be and ^{16} C neutron-rich isotopes is investigated via projectile break-up reactions induced on polyethylene (CH _2 target. We used a fragmentation beam constituted by 55MeV/u ^{10} Be and 49MeV/u ^{16} C beams provided by the FRIBs facility at INFN-LNS. Invariant mass spectra of 4{He}+ 6 He and 6{He} + ^{10} Be breakup fragments are reconstructed by means of the CHIMERA 4π detector to investigate the presence of excited states of projectile nuclei characterized by cluster structure. In the first case, we suggest the presence of a new state in ^{10} Be at 13.5MeV. A non-vanishing yield corresponding to 20.6MeV excitation energy of ^{16} C was observed in the 6{He} + ^{10} Be cluster decay channel. To improve the results of the present analysis, a new experiment has been performed recently, taking advantage of the coupling of CHIMERA and FARCOS. In the paper we describe the data reduction process of the new experiment together with preliminary results.

  10. 75 FR 43329 - Interim Final Rules for Group Health Plans and Health Insurance Issuers Relating to Internal...

    Science.gov (United States)

    2010-07-23

    ... 45 CFR Part 147 Interim Final Rules for Group Health Plans and Health Insurance Issuers Relating to... Interim Final Rules for Group Health Plans and Health Insurance Issuers Relating to Internal Claims and... of Labor; Office of Consumer Information and Insurance Oversight, Department of Health and Human...

  11. 75 FR 27141 - Group Health Plans and Health Insurance Issuers Providing Dependent Coverage of Children to Age...

    Science.gov (United States)

    2010-05-13

    ... Group Health Plans and Health Insurance Issuers Providing Dependent Coverage of Children to Age 26 Under... Information and Insurance Oversight of the U.S. Department of Health and Human Services are issuing substantially similar interim final regulations with respect to group health plans and health insurance coverage...

  12. 75 FR 41787 - Requirement for Group Health Plans and Health Insurance Issuers To Provide Coverage of Preventive...

    Science.gov (United States)

    2010-07-19

    ... Requirement for Group Health Plans and Health Insurance Issuers To Provide Coverage of Preventive Services... Insurance Oversight of the U.S. Department of Health and Human Services are issuing substantially similar interim final regulations with respect to group health plans and health insurance coverage offered in...

  13. Recombination in the evolution of enterovirus C species sub-group that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99.

    Directory of Open Access Journals (Sweden)

    Teemu Smura

    Full Text Available Genetic recombination is considered to be a very frequent phenomenon among enteroviruses (Family Picornaviridae, Genus Enterovirus. However, the recombination patterns may differ between enterovirus species and between types within species. Enterovirus C (EV-C species contains 21 types. In the capsid coding P1 region, the types of EV-C species cluster further into three sub-groups (designated here as A-C. In this study, the recombination pattern of EV-C species sub-group B that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99 was determined using partial 5'UTR and VP1 sequences of enterovirus strains isolated during poliovirus surveillance and previously published complete genome sequences. Several inter-typic recombination events were detected. Furthermore, the analyses suggested that inter-typic recombination events have occurred mainly within the distinct sub-groups of EV-C species. Only sporadic recombination events between EV-C species sub-group B and other EV-C sub-groups were detected. In addition, strict recombination barriers were inferred for CVA-21 genotype C and CVA-24 variant strains. These results suggest that the frequency of inter-typic recombinations, even within species, may depend on the phylogenetic position of the given viruses.

  14. Overexpression of c-erbB-2 and loss of p16 have molecular diagnostic relevance but no prognostic value in lung cancer.

    Science.gov (United States)

    Feng, Xiao-li; Li, Ling; Gao, Yan-ning; Zhang, Jian-jun; Xiao, Ting; Ying, Jian-ming; Gao, Ji-dong; Sun, Yun-tian; Cheng, Shu-jun

    2011-03-01

    This study was designed to evaluate the expression of C-erbB-2 and p16 in lung cancers using tissue microarray technology and to determine their clinical and pathological significance. Immunohistochemical C-erbB-2 and p16 expressions and their associations with clinical and pathological features were analyzed in two tissue microarrays. The membranous and cytoplasmic expression rates of C-erbB-2 were 40.5 and 66.5% in non-small cell lung cancers (NSCLCs), and 0 and 9.5% in small cell lung cancers (SCLCs), respectively. The nuclear and cytoplasmic expression rates of p16 were 11.5 and 32.2% in NSCLs, and 45 and 80% in SCLCs, respectively. The cytoplasmic expression of both C-erbB-2 and p16 was more frequent than the membranous expression of C-erbB-2 and the nuclear expression of p16. The rates of overexpression of C-erbB-2 and loss of p16 expression were significantly higher in NSCLCs than in SCLCs (P < 0.05). Neither C-erbB-2 nor p16 expression was significantly associated with age, tumor grade or stage, presence of lymph node metastasis or survival duration. The abnormal expressions of p16 and C-erbB-2 may play a role in the progression of lung cancers. The variations in the expression patterns of C-erbB-2 and p16 between NSCLCs and SCLCs may aid the molecular classification of lung cancer. The abnormal expression of p16 may be involved in the development of NSCLCs, and the overexpression of C-erbB-2 in NSCLCs indicates that it can be a candidate target for gene therapy.

  15. Biological study of some labeled C16 fatty acids

    Energy Technology Data Exchange (ETDEWEB)

    Riche, F.; Mathieu, J.P.; Busquet, G.; Vidal, M.; Comet, M.; Pernin, C. (C.H.R.U. de Grenoble, 38 - La Tronche (France)); Godart, J.; Benabed, A. (Institut des Sciences Nucleaires, 38 - Grenoble (France)); Bardy, A. (C.E.A.-ORIS, 91 - Gif-sur-Yvette (France))

    1983-01-01

    The evolution of myocardial, blood, liver and kidney activity is studied in mice after I.V. injection of some labelled C16 fatty acids. With ..omega.. iodo fatty acids, the presence or absence of a double bond and the character Z or E have no influence on the tissue activity. The presence of a triple bond decreases the fixation, modifies the intramyocardial metabolism of the fatty acid and accelerates the rate of decrease of myocardial activity. ..omega.. bromo fatty acid have the same maximal fixation as ..omega.. iodo fatty acid but a more rapid decrease of myocardial activity. ..cap alpha.. iodo fatty acid has a very low myocardial fixation.

  16. Biological study of some labeled C16 fatty acids

    International Nuclear Information System (INIS)

    Riche, F.; Mathieu, J.P.; Busquet, G.; Vidal, M.; Comet, M.; Pernin, C.; Godart, J.; Benabed, A.; Bardy, A.

    1983-01-01

    The evolution of myocardial, blood, liver and kidney activity is studied in mice after I.V. injection of some labelled C16 fatty acids. With ω iodo fatty acids, the presence or absence of a double bond and the character Z or E have no influence on the tissue activity. The presence of a triple bond decreases the fixation, modifies the intramyocardial metabolism of the fatty acid and accelerates the rate of decrease of myocardial activity. ω bromo fatty acid have the same maximal fixation as ω iodo fatty acid but a more rapid decrease of myocardial activity. α iodo fatty acid has a very low myocardial fixation [fr

  17. 42 CFR 422.106 - Coordination of benefits with employer or union group health plans and Medicaid.

    Science.gov (United States)

    2010-10-01

    ... group health plans and Medicaid. 422.106 Section 422.106 Public Health CENTERS FOR MEDICARE & MEDICAID... plans and Medicaid. (a) General rule. If an MA organization contracts with an employer, labor... enrollees in an MA plan, or contracts with a State Medicaid agency to provide Medicaid benefits to...

  18. 75 FR 43109 - Requirements for Group Health Plans and Health Insurance Issuers Relating to Internal Claims and...

    Science.gov (United States)

    2010-07-23

    ... Requirements for Group Health Plans and Health Insurance Issuers Relating to Internal Claims and Appeals and... the Office of Consumer Information and Insurance Oversight of the U.S. Department of Health and Human... health insurance coverage offered in connection with a group health plan under the Employee Retirement...

  19. Neutron spectra and level density parameters from 16O + 12C fusion reaction

    International Nuclear Information System (INIS)

    Kasagi, J.; Remington, B.; Galonsky, A.; Haas, F.; Racca, R.; Prosser, F.W.

    1985-01-01

    Residues following 16 O + 12 C fusion were identified by their characteristic γ-rays. For several transitions in 23 Mg, 25 Mg, and 26 Al coincident neutron spectra were measured at six angles. Through use of the evaporation code CASCADE, comparisons were made of these spectra with predictions of the statistical model at five 16 O projectile energies between 43.2 and 56.0 MeV. The results require an excitation energy dependence for the effective radius parameter r 0 which determines the spin cutoff factor

  20. 75 FR 34537 - Interim Final Rules for Group Health Plans and Health Insurance Coverage Relating to Status as a...

    Science.gov (United States)

    2010-06-17

    ... 45 CFR Part 147 Group Health Plans and Health Insurance Coverage Relating to Status as a... for Group Health Plans and Health Insurance Coverage Relating to Status as a Grandfathered Health Plan... and Insurance Oversight, Department of Health and Human Services. ACTION: Interim final rules with...

  1. Different Erythromycin Resistance Mechanisms in Group C and Group G Streptococci

    OpenAIRE

    Kataja, Janne; Seppälä, Helena; Skurnik, Mikael; Sarkkinen, Hannu; Huovinen, Pentti

    1998-01-01

    Different mechanisms of erythromycin resistance predominate in group C and G streptococcus (GCS and GGS, respectively) isolates collected from 1992 to 1995 in Finland. Of the 21 erythromycin-resistant GCS and 32 erythromycin-resistant GGS isolates, 95% had the mefA or mefE drug efflux gene and 94% had the ermTR methylase gene, respectively.

  2. β-delayed α decay of {sup 16}N and the {sup 12}C(α,γ){sup 16}O cross section at astrophysical energies: A new experimental approach

    Energy Technology Data Exchange (ETDEWEB)

    Sanfilippo, S., E-mail: simone.sanfilippo@studium.unict.it [Dipartimento di Fisica e Astronomia, Università degli Studi di Catania, Via S.Sofia 64, 95123 Catania (Italy); Cherubini, S.; Lattuada, M.; Spitaleri, C. [Dipartimento di Fisica e Astronomia, Università degli Studi di Catania, Via S.Sofia 64, 95123 Catania, Italy and INFN - Laboratori Nazionali del Sud, Catania (Italy); Hayakawa, S.; Di Pietro, A.; Figuera, P.; La Cognata, M. [INFN - Laboratori Nazionali del Sud, Catania (Italy); Gulino, M. [INFN - Laboratori Nazionali del Sud, Catania, Italy and Università Kore, Enna (Italy); Yamaguchi, H.; Kahl, D.; Nakao, T. [Center for Nuclear Study, University of Tokyo, Wako Branch, Saitama (Japan); Kubono, S.; Wakabayashi, Y. [RIKEN Nishina Center, Wako, Saitama (Japan); Hashimoto, T. [RCNP, Osaka University, Osaka (Japan); Iwasa, N.; Okoda, Y.; Ushio, K. [Department of Physics, Tohoku University, Sendai (Japan); Teranishi, T. [Department of Physics, Kyushu University, Fukuoka (Japan); Mazzocco, M. [Dipartimento di Fisica e Astronomia, Università di Padova and INFN-Sez. Padova, Padova (Italy); and others

    2015-02-24

    The {sup 12}C(α,γ){sup 16}O reaction at energies corresponding to the quiescent helium burning in massive stars is regarded as one of the most important processes in nuclear astrophysics. Although this process has being studied for over four decades, our knowledge of its cross section at the energies of interest for astrophysics is still widely unsatisfactory. Indeed, no experimental data are available around 300 keV and in the energy region of astrophysical interest extrapolations are performed using some theoretical approaches, usually R-matrix calculations. Consequently, the published astrophysical factors range from 1 to 288 keVb for S{sub E1}(300) and 7 to 120 keVb for S{sub E2}(300), especially because of the unknown contribution coming from subthreshold resonances. To improve the reliability of these extrapolations, data from complementary experiments, such as elastic and quasi- elastic α scattering on {sup 12}C, α-transfer reactions to {sup 16}O, and {sup 16}N decay are usually included in the analysis. Here the β-delayed α decay of {sup 16}N is used to infer information on the {sup 12}C(α,γ){sup 16}O reaction and a new experimental technique is suggested.

  3. Hydrogen bonds and van der Waals forces as tools for the construction of a herringbone pattern in the crystal structure of hexane-1,6-diaminium hexane-1,6-diyl bis(hydrogen phosphonate

    Directory of Open Access Journals (Sweden)

    Guido J. Reiss

    2017-01-01

    Full Text Available The asymmetric unit of the title salt, [H3N(CH26NH3][(HOO2P(CH26PO2(OH], consists of one half of a hexane-1,6-diaminium dication and one half of a hexane-1,6-diyl bis(hydrogen phosphonate dianion. Both are located around different centres of inversion (Wyckoff sites: 2a and 2d of the space group P21/c. The shape of the hexane-1,6-diaminium cation is best described as a double hook. Both aminium groups as well as the two attached CH2 groups are turned out from the plane of the central four C atoms. In contrast, all six C atoms of the dianion are almost in a plane. The hydrogen phosphonate (–PO3H groups of the anions and the aminium groups of the cations form two-dimensional O—H... and O—H...N hydrogen-bonded networks parallel to the ac plane, built up from ten-membered and twelve-membered ring motifs with graph-set descriptors R33(10 and R54(12, respectively. These networks are linked by the alkylene chains of the anions and cations. The resulting three-dimensional network shows a herringbone pattern, which resembles the parent structures 1,6-diaminohexane and hexane-1,6-diphosphonic acid.

  4. Generation of a library of two-group diffusion parameters for SPPS-1,6 by HELIOS

    International Nuclear Information System (INIS)

    Petkov, P.T.; Haralampieva, C.V.; Simeonov, T.; Stojanova, I.; Kamenov, K.

    2000-01-01

    The two-group three-dimensional nodal diffusion code SPPS-1.6 has been used for many years for steady-state neutronics calculations of the WWER-440 reactors at Kozloduy NPP. The old library of two-group diffusion parameters for SPPS-1.6 has been generated by WIMSD4 with a nuclear data library compiled from three different libraries. The current paper presents our experience in generating a new library for SPPS-1.6 by the HELIOS lattice code. The accuracy of the current-coupling collision probability (CCCP) method in calculating a single WWER-440 assembly has been studied first. Among all possible angular discretization of the interface partial currents, called coupling orders, only coupling order 3 is suitable for hexagonal cells. Dividing each cell side into 3 segments an accuracy of 100 pcm has been achieved. The accuracy in calculating the absorber problem was estimated at 1%, which means about 10% error in the control assemblies efficiency. The accuracy for small core-reflector problems is 1% as well. The general conclusion is that HELIOS is accurate enough for assembly calculations, but inadequate for absorber and core-reflector problems. (Authors)

  5. Experimental measurement of the 12C+16O fusion cross sections at astrophysical energies

    Science.gov (United States)

    Fang, X.; Tan, W. P.; Beard, M.; deBoer, R. J.; Gilardy, G.; Jung, H.; Liu, Q.; Lyons, S.; Robertson, D.; Setoodehnia, K.; Seymour, C.; Stech, E.; Vande Kolk, B.; Wiescher, M.; de Souza, R.; Hudan, S.; Singh, V.; Tang, X. D.; Uberseder, E.

    2018-05-01

    The total cross sections of the 12C+16O fusion have been experimentally determined at low energies to investigate the role of this reaction during late stellar evolution burning phases. A high-intensity oxygen beam was produced by the 5MV pelletron accelerator at the University of Notre Dame impinging on a thick ultra-pure graphite target. Protons and γ-rays were measured simultaneously in the center-of-mass energy range from 3.64 to 5.01 MeV, using strip silicon and HPGe detectors. Statistical model calculations were employed to interpret the experimental results. A new broad resonance-like structure is observed for the 12C+16O reaction, and a decreasing trend of its S-factor towards low energies is found.

  6. Nonstatistical fluctuation in 16O-Ag/Br collisions at 200 A GeV/c

    International Nuclear Information System (INIS)

    Ghosh, M.K.; Mukhopadhyay, A.; Haldar, P.K.; Manna, S.K.; Singh, G.

    2009-01-01

    Presence of non-statistical fluctuations in the density distribution of singly charged particles produced in 16 O-Ag/Br interactions at an incident momentum of 200A GeV/c, has been identified and characterized with the help of the intermittency technique. Nuclear photoemulsion data on 16 O-Ag/Br events have been used in the analysis. In each of the 280 events present in the sample, the projectile nucleus underwent complete fragmentation

  7. Irradiation project of SiC/SiC fuel pin 'INSPIRE': Status and future plan

    International Nuclear Information System (INIS)

    Kohyama, Akira; Kishimoto, Hirotatsu

    2015-01-01

    After the March 11 Disaster in East-Japan, Research and Development towards Ensuring Nuclear Safety Enhancement for LWR becomes a top priority R and D in nuclear energy policy of Japan. The role of high temperature non-metallic materials, such as SiC/SiC, is becoming important for the advanced nuclear reactor systems. SiC fibre reinforced SiC composite has been recognised to be the most attractive option for the future, now, METI fund based project, INSPIRE, has been launched as 5-year termed project at OASIS in Muroran Institute of Technology aiming at early realisation of this system. INSPIRE is the irradiation project of SiC/SiC fuel pins aiming to accumulate material, thermal, irradiation effect data of NITE-SiC/SiC in BWR environment. Nuclear fuel inserted SiC/SiC fuel pins are planned to be installed in the Halden reactor. The project includes preparing the NITE-SiC/SiC tubes, joining of end caps, preparation of rigs to control the irradiation environment to BWR condition and the instruments to measure the condition of rigs and pins in operation. Also, basic neutron irradiation data will be accumulated by SiC/SiC coupon samples currently under irradiation in BR2. The output from this project may present the potentiality of NITE-SiC/SiC fuel cladding with the first stage fuel-cladding interaction. (authors)

  8. 78 FR 25758 - Migratory Birds; Eagle Conservation Plan Guidance: Module 1-Land-Based Wind Energy, Version 2

    Science.gov (United States)

    2013-05-02

    ...-FXMB123209EAGL0L2] RIN 1018-AX53 Migratory Birds; Eagle Conservation Plan Guidance: Module 1-- Land-Based Wind... Migratory Bird Management, U.S. Fish and Wildlife Service, 4401 North Fairfax Drive, Arlington, Virginia... Act (BGEPA) (16 U.S.C. 668-668c), the Migratory Bird Treaty Act (MBTA) (16 U.S.C. 703-12), and the...

  9. Group lattices with applications to the molecule C60

    International Nuclear Information System (INIS)

    Stuart, S.

    1993-01-01

    A brief introduction to group lattices and their application to the electronic structure of C 6 0 is presented. Group lattice methods with experimental results yield a fairly clear picture of the electronic energy levels. (Author) 7 refs

  10. Evaluation of fatigue properties of HFIR-irradiated nimonic PE-16 at 4300C

    International Nuclear Information System (INIS)

    Grossbeck, M.L.; Liu, K.C.

    1984-01-01

    Nimonic PE-16 was irradiated in the HFIR to 6 to 9 dpa and 560 to 1000 at. ppM He at 430 0 C. Postirradiation fatigue tests revealed a reduction in fatigue life by about a factor of 10 at 430 0 C. In contrast with AISI type 316 stainless steel, no endurance limit was observed. All irradiated specimens exhibited some intergranular fracture with an increasing tendency toward cleavage like intragranular fracture for low strain ranges

  11. Some Remarks on Group Bundles and C* Dynamical Systems

    Science.gov (United States)

    Vasselli, Ezio

    2007-08-01

    We introduce the notion of fibred action of a group bundle on a C(X)-algebra. By using such a notion, a characterization in terms of induced C*-bundles is given for C*-dynamical systems such that the relative commutant of the fixed-point C*-algebra is minimal (i.e., it is generated by the centre of the given C*-algebra and the centre of the fixed-point C*-algebra). A class of examples in the setting of the Cuntz algebra is given, and connections with superselection structures with nontrivial centre are discussed.

  12. 16-Channel surface coil for 13C-hyperpolarized spectroscopic imaging of cardiac metabolism in pig heart

    DEFF Research Database (Denmark)

    Frijia, Francesca; Santarelli, Maria Filomena; Koellisch, Ulrich

    2016-01-01

    Magnetic resonance spectroscopy (MRS) of hyperpolarized 13C pyruvate and its metabolites in large animal models is a powerful tool for assessing cardiac metabolism in patho-physiological conditions. In 13C studies, a high signal-to-noise ratio (SNR) is crucial to overcome the intrinsic data quality...... both targets. In this study, a 16-channel receive surface coil was designed for 13C hyperpolarized studies of the pig heart with a clinical 3-T scanner. The coil performance was characterized by phantom experiments and compared with that of a birdcage coil used in transmit/receive mode. Segmental...... of the 16-channel coil is recommended for studies of septal and anterior LV walls....

  13. Diffraction model analysis of vector polarized 6Li elastic scattering on 12C, 16O, 28Si, and 58Ni nuclei

    International Nuclear Information System (INIS)

    Rabie, A.; El-Gazzar, M.A.; Abul-Magd, A.Y.

    1980-11-01

    Using an assumption concerning the spin-orbit potential, it was possible to reduce the five amplitudes of scattering of spin-1 projectiles to two amplitudes. The summations over the partial waves were evaluated by the Regge pole technique. The resulting simple expressions were used to analyze the data of the Heidelberg group for polarized 6 Li ions scattered on 12 C, 16 O, 28 Si and 58 Ni to give a reasonable fitting both for the differential cross-section and vector polarization. (author)

  14. Activity Plans of Group Games for Social and Emotional Development of Kindergarten Children in Korea.

    Science.gov (United States)

    Choi, Kee Young

    Although classroom group games have been used to effectively teach mathematics in Korean kindergarten, ethnographic research has revealed some unexpected negative effects of such games on young children due to children's over-competitiveness and the teacher's unskilled group management. This paper proposes some activity plans for group games to…

  15. Synthesis, radiosynthesis and in vitro evaluation of 18F-Bodipy-C16/triglyceride as a dual modal imaging agent for brown adipose tissue.

    Directory of Open Access Journals (Sweden)

    Andreas Paulus

    Full Text Available Brown adipose tissue research is in the focus in the field of endocrinology. We designed a dual-modal fluorescent/PET fatty acid based tracer on commercially available Bodipy-C16, which can be synthesized to its corresponding triglyceride and which combines the benefits of fluorescent and PET imaging.Bodipy-C16 was coupled to 1,3-diolein resulting in Bodipy-triglyceride. Bodipy-C16 and Bodipy-triglyceride compounds were radiolabeled with 18F using an 18F/19F exchange reaction to yield a dual-modal imaging molecule. Uptake of radiolabeled and non-labeled Bodipy-C16 and Bodipy-triglyceride was analyzed by fluorescence imaging and radioactive uptake in cultured adipocytes derived from human brown adipose tissue and white adipose tissue.Bodipy-C16 and Bodipy-triglyceride were successfully radiolabeled and Bodipy-C16 showed high shelf life and blood plasma stability (99% from 0-4 h. The uptake of Bodipy-C16 increased over time in cultured adipocytes, which was further enhanced after beta-adrenergic stimulation with norepinephrine. The uptake of Bodipy-C16 was inhibited by oleic acid and CD36 inhibitor sulfosuccinimidyl-oleate. The poor solubility of Bodipy-triglyceride did not allow stability or in vitro experiments.The new developed dual modal fatty acid based tracers Bodipy-C16 and Bodipy-triglyceride showed promising results to stimulate further in vivo evaluation and will help to understand brown adipose tissues role in whole body energy expenditure.

  16. A Randomized Controlled Trial of an Eczema Care Plan.

    Science.gov (United States)

    Rea, Corinna J; Tran, Katherine D; Jorina, Maria; Wenren, Larissa M; Hawryluk, Elena B; Toomey, Sara L

    2018-03-02

    To test whether an eczema care plan (ECP) would improve provider documentation and management, decrease eczema severity, and increase patient quality of life (QOL) in the pediatric primary care setting. We conducted a randomized controlled trial from June 2015 to September 2016 at a large hospital-based pediatric primary care clinic. Participants included children from 1 month to 16 years of age with a diagnosis of eczema. The intervention group received the ECP and the control group received usual care. Both groups completed a validated eczema severity scale (Patient-Oriented Eczema Measure [POEM]) and a QOL scale (Infant's Dermatitis Quality of Life Index [IDQOL]) or Children's Dermatology Life Quality Index [CDLQI]) before the visit and again ~1 month later. A total of 211 caregivers completed both the pre- and postintervention surveys (100 control group and 111 intervention group [94% completion]). Intervention group providers were more likely to recommend a comprehensive "step-up" plan (88%) vs 28%; P plan to families (80%) vs 2%; P improved between the pre- and postintervention periods. However, there was not a significant difference between the groups on either measure: POEM difference -0.8, 95% confidence interval (CI) -3.2 to 1.7; IDQOL difference -0.1, 95% CI -1.8 to 1.6; CDLQI difference 0.8, 95% CI -0.9 to 2.6. Intervention group providers documented more comprehensive eczema care than control group providers. Although patients improved on all measures in the postintervention period, the ECP did not augment that improvement. Copyright © 2018 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

  17. [PRELIMINARY APPLICATION OF VIRTUAL PREOPERATIVE RECONSTRUCTION PLANNING IN Pilon FRACTURES].

    Science.gov (United States)

    Wang Xiaoping; Wei, Zhantu; Huang, Jian; Chen, Luyao; Hu, Shiqiang; Wu, Weiwei; Tu, Yumin; Guo, Sheng; Xu, Guotai; Deng, Zhicheng

    2016-01-01

    To investigate the application value of three-dimensional reconstruction and virtual preoperative planning for Pilon fractures. Between July 2010 and June 2014, 16 patients with closed Pilon fracture were treated, including 12 males and 4 females with an average age of 36.5 years (range, 22-53 years) and a mean disease duration of 10.2 days (range, 6-14 days). According to AO/Orthopaedic Trauma Association (AO/OTA) typing, 2 cases were rated as 43.B2 type, 3 cases as 43.B3 type, 3 cases as 43.C1 type, 2 cases as 43.C2 type, and 6 cases as 43.C3 type. The preoperative CT data from 16 patients were imported into Mimics10.01 software to establish the detailed fracture three-dimensional digital models. Virtual operation of fracture reduction and implanting internal fixation was performed on the models, and the optional surgical planning was made. Based on the virtual preoperative planning, operations were performed. Established detailed three-dimensional Pilon fracture digital models could perfectly reflect the fracture characteristics, could be observed at any direction, and aided for fracture classification accurately. Virtual fracture operations of reduction, internal fixation and other could be performed to simulate the clinical operation, which could assist the surgeon better preoperative planning in achieving visual presentation and improving the communication. The operation time was 70-130 minutes (mean, 87.8 minutes); intraoperative blood loss volume was 30-150 mL (mean, 71.9 mL). The wounds healed by first intension in all patients. The mean follow-up time was 11.6 months (range, 8-18 months). Postoperative radiological results at 3 groups showed good anatomic reduction according to the Burwell-Charnley criteria, and the fracture healing time was 3-6 months (mean, 3.7 months). There was no complication of internal fixation loosening or breakage during follow-up. The American Orthopedic Foot and Ankle Society (AOFAS) score was 71-100 (mean, 92.3); the results

  18. Variantes del Papilomavirus Humano 16 y su asociación con el HLA en cáncer cervical Variants of Human Papillomavirus 16 and its association with HLA in cervical cancer

    Directory of Open Access Journals (Sweden)

    Jehidys Montiel Ramos

    2010-12-01

    Full Text Available El cáncer cervical es el segundo cáncer más común en mujeres en el mundo y es el principal cáncer en mujeres en países en desarrollo. La infección persistente por los genotipos oncogénicos del Virus del Papiloma Humano (VPH es la causa necesaria para el desarrollo del cáncer cervical, siendo el VPH-16 el genotipo responsable del 50-60% de los casos. Las variantes No Europeas del VPH-16 han sido asociadas con infección persistente, lesiones de alto grado y cáncer. Los polimorfismos del Antígeno Leucocitario Humano (HLA están también asociados con la susceptibilidad al cáncer cervical y se ha postulado una relación entre variantes del VPH y ciertos alelos del HLA. La presente revisión hace referencia a la relación entre los polimorfismos de HLA y el desarrollo de cáncer cervical y la evidencia que documenta la interrelación de este factor con la variabilidad del VPH-16. Salud UIS 2010; 42: 272-280Cervical cancer is the second most common cancer in women worldwide and the most frequent cancer in women of the majority of developing countries. Persistent infection with Human Papillomavirus (HPV oncogenic types of HPV is necessary to develop cervical, cancer, with HPV-16 responsible for 50-60% of cases. Non-European variants of HPV-16 have been associated with persistant infection and high degree cervical cancer. Human Leucocyte Antigen (HLA polymorphisms are also associated with susceptibility to cervical cancer. It has been suggested relationship between HPV-16 variability and some HLA Alleles., This revision refers to the relation between HLA polymorphisms and cervical cancer development, and present evidence that may explain its relation with HPV-16 variability. Salud UIS 2010; 42: 272-280

  19. THE RELATIONSHIP BETWEEN MOTOR COMPETENCE AND PHYSICAL FITNESS IS WEAKER IN THE 15-16 YR. ADOLESCENT AGE GROUP THAN IN YOUNGER AGE GROUPS (4-5 YR. AND 11-12 YR.).

    Science.gov (United States)

    Haga, Monika; Gísladóttír, Thórdís; Sigmundsson, Hermundur

    2015-12-01

    Developing motor competence and physical fitness can affect the maintenance of a sufficient level of physical activity in children and adolescents. This study assesses the relationship between motor competence and physical fitness from childhood through early adolescence. A cross-sectional sample of 194 participants from 4 to 16 years old were divided into three groups; 4-6 yr. (n=42, M age=5.2, SD 0.6), 11-12 yr. (n=58, M age=12.4, SD=0.3), and 15-16 yr. (n=94, M age=15.9, SD=0.4). To assess motor competence, each child completed the Movement Assessment Battery for Children (MABC). To measure physical fitness, three tasks (strength, speed, and endurance) were selected from the Test of Physical Fitness (TPF). To analyze the significance of the difference between the correlation coefficient in the three age groups (samples) (4-6, 11-12, and 15-16 yr.), Fischer r-to-z transformation was used. The correlation (Pearson's) between motor competence and physical fitness in the age groups was statistically higher for the youngest age groups (4-6 and 11-12 yr.) and the adolescent group (age 15-16). The differences between the two youngest age groups were not statistically significant. The results demonstrate that the correlation between motor competence and physical fitness decreases with age.

  20. Minnesota urban partnership agreement national evaluation : surveys, interviews, and focus groups test plan.

    Science.gov (United States)

    2009-11-17

    This report presents the test plan for developing, conducting, and analyzing surveys, interviews, and focus groups for evaluating the Minnesota Urban Partnership Agreement (UPA) under the United States Department of Transportation (U.S. DOT) UPA Prog...

  1. Sample collection and sample analysis plan in support of the 105-C/190-C concrete and soil sampling activities

    International Nuclear Information System (INIS)

    Marske, S.G.

    1996-07-01

    This sampling and analysis plan describes the sample collection and sample analysis in support of the 105-C water tunnels and 190-C main pumphouse concrete and soil sampling activities. These analytical data will be used to identify the radiological contamination and presence of hazardous materials to support the decontamination and disposal activities

  2. Quantum mechanics, group theory, and C60

    International Nuclear Information System (INIS)

    Rioux, F.

    1994-01-01

    The recent discovery of a new allotropic form of carbon and its production in macroscopic amounts has generated a tremendous amount of research activity in chemistry, physics, and material science. It has also provided educators with an exciting new vehicle for breathing fresh life into some old, well-established methods and principles. Recently, for example, Boo demonstrated the power of group theory in classifying existing and hypothetical fullerenes by their symmetries. In a similar spirit this note describes a model for the electronic structure of C 60 based on the most elementary principles of quantum mechanics and group theory

  3. Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16.

    Science.gov (United States)

    Havermann, Susannah; Humpf, Hans-Ulrich; Wätjen, Wim

    2016-09-01

    The flavonoid baicalein has been demonstrated to be an activator of the transcription factor Nrf2 in mammalian cell lines. We show that it further modulates the Nrf2 homolog SKN-1 in Caenorhabditis elegans and by this pathway mediates beneficial effects in the nematode: baicalein enhances the resistance of C. elegans against lethal thermal and sodium arsenite stress and dose-dependently prolongs the life span of the nematode. Using RNA interference against SKN-1 we were able to show that the induction of longevity and the enhanced stress-resistance were dependent on this transcription factor. DAF-16 (homolog to mammalian FOXO) is another pivotal aging-related transcription factor in the nematode. We demonstrate that DAF-16 does not participate in the beneficial effects of baicalein: since baicalein causes no increase in the nuclear translocation of DAF-16 (DAF-16::GFP expressing strain, incubation time: 1h) and it still induces longevity even in a DAF-16 loss-of-function strain, we conclude, that baicalein increases stress-resistance and life span in C. elegans via SKN-1 but not DAF-16. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Planning the annual cycle in groups of cadet combat sports perfection

    Directory of Open Access Journals (Sweden)

    Ananchenko Konstantin

    2016-08-01

    Full Text Available Within a large training cycle in conditions of high general level of stress the authors recommend optimal implementation of planning undulating dynamics of cadets’ combat exercise stress. The article proves the efficiency of one-cycle construction of training highly- qualified single-combat cadets at the stage of maximal realization of sporting possibilities, which includes both features of traditional cycles (preparatory, competitional, transitional and module-sectional composition of training. It scientifically substantiates, that the choice of those or other types of microcycles which present the structure of mesocycles is determined by a few basic factors which must be necessarily taken into account while planning the training process of sportsmen of different qualification. It is suggested to use certain varieties of microcycles in the practice of preparation of single combat cadets. It is substantiated that accounting in planning the annual cycle in groups of sporting perfection of students of the educed types of microcycles for every type of single combats is an actual task of further scientific research.

  5. Hepatitis C infection in risk groups

    Directory of Open Access Journals (Sweden)

    Sead Ahmetagić

    2006-11-01

    Full Text Available Hepatitis C infection is important global health problem with wide spectrum of health, social and economic consequences. The goal of this research was to estimate prevalence of hepatitis C virus infection in risk groups, and to determine association hepatitis C virus (HCV infection and risk factors. Research included 4627 subjects divided in two groups. Test group included 2627 subjects divided in 4 subgroups with risk for HCV infection: those who received blood transfusion without screening on HCV (it was introduced in 1995 (700; intravenous drug users (60; patients on hemodialysis (168 and health care workers (1699. Control group included 2000 healthy volunteer blood donors. In all subjects anti-HCV antibodies were tested with third generation ELISA test. Positive serum samples were tested for presence of HCVRNA, using reaction of reverse transcription and polymerase chain reaction. In all anti-HCV positive subjects further epidemiological and clinical workup was performed. Prevalence of HCV infection in risk groups was: 4.6% in subjects who have received blood transfusions without HCV blood screening, 35% in intravenous drug users, 58.9% in patients on chronic dialysis, and 0.4% in health care workers. In control group prevalence was low (0.2%. In the group of 158 anti-HCV positive subjects, 73.4% had HCVRNA. The largest number of subjects with HCV infection was in the age group of 30-49 years (45.8%. This study showed that multiple blood transfusions before introducing the blood screening for HCV, longer duration of intravenous drug abuse, longer duration of hemodialysis treatment, larger number of accidental injuries in health care workers are independent and statistically significant risk factors for those groups examined. Results of this study confirm that general screening for HCV infection is recommended in risk groups for HCV infection in order to identify to prevent and to treat it.

  6. Structures, Bonding, and Energetics of Potential Triatomic Circumstellar Molecules Containing Group 15 and 16 Elements.

    Science.gov (United States)

    Turner, Walter E; Agarwal, Jay; Schaefer, Henry F

    2015-12-03

    The recent discovery of PN in the oxygen-rich shell of the supergiant star VY Canis Majoris points to the formation of several triatomic molecules involving oxygen, nitrogen, and phosphorus; these are also intriguing targets for main-group synthetic inorganic chemistry. In this research, high-level ab initio electronic structure computations were conducted on the potential circumstellar molecule OPN and several of its heavier group 15 and 16 congeners (SPN, SePN, TePN, OPP, OPAs, and OPSb). For each congener, four isomers were examined. Optimized geometries were obtained with coupled cluster theory [CCSD(T)] using large Dunning basis sets [aug-cc-pVQZ, aug-cc-pV(Q+d)Z, and aug-cc-pVQZ-PP], and relative energies were determined at the complete basis set limit of CCSDT(Q) from focal point analyses. The linear phosphorus-centered molecules were consistently the lowest in energy of the group 15 congeners by at least 6 kcal mol(-1), resulting from double-triple and single-double bond resonances within the molecule. The linear nitrogen-centered molecules were consistently the lowest in energy of the group 16 congeners by at least 5 kcal mol(-1), due to the electronegative central nitrogen atom encouraging electron delocalization throughout the molecule. For OPN, OPP, and SPN, anharmonic vibrational frequencies and vibrationally corrected rotational constants are predicted; good agreement with available experimental data is observed.

  7. <90 day storage training plan for the 103-B, 1701-BA, AND 1714-C buildings

    International Nuclear Information System (INIS)

    Snider, P.M.

    1996-10-01

    The 103-B, 1701-BA, and 1714C < 90 Day Storage Area stores characteristic wastes generated in the demolition of the 103-B, 1701-BA, and 1714-C Complex. Wastes (lead-based painted components) are packaged and stored in vendor shipment containers. This is the Environmental Restoration Contractor team training plan for the 103-B, 1701-BA, and 1714-C subgrade demolition < 90 Day Storage of Hazardous Waste. This document is intended to meet the requirements of Washington Administrative Code 173-303-330 and the Hanford Dangerous Waste Permit. Training unrelated to compliance with WAC 173-303-330 is not addressed in this training plan. WAC 173-303-330(1)(d)(2, 5, 6) requires that personnel be familiarized, where applicable, with waste feed cut-off systems, response to ground-water contamination incidents, and shutdown of operations. These are not applicable to 103-B, 1701-BA, and 1714-C Subgrade Demolition < 90 Day Storage, and therefore are not covered in this training plan

  8. Role of the C-E owner group in the nuclear industry

    International Nuclear Information System (INIS)

    Gasper, J.K.

    1988-01-01

    The Combustion Engineering (C-E) owner group was formed in 1979 to address the technical and regulatory issues for plants with nuclear steam supply systems supplied by C-E that resulted from the accident at the Three Mile Island plant. The group addressed many of the immediate concerns from the accident including the response of C-E owner-group plants to small-break loss-of-coolant accidents, the use of power-operated relief valves, emergency operating procedure upgrades, as well as transient and accident responses. The group was successful in addressing these technical and regulatory issues with the US Nuclear Regulatory Commission in such a manner that C-E owner-group plants were not required to shut down or operate at reduced power levels. In recent years, the group has increasingly pursued programs for the benefit of its members rather than because of a regulatory commitment. The major current activities of the group are programs to support the design basis reconstruction of our member plants, improvements to emergency procedure guidelines, which are the basis for the emergency operating procedures used in our plants, a charging pump performance improvement program, various activities to reduce the number of unplanned reactor scrams at our plants, modeling of steam generator corrosion mechanisms to improve steam generator performance, and leak-before-break justification of reactor coolant system piping

  9. Power Distribution System Planning Evaluation by a Fuzzy Multi-Criteria Group Decision Support System

    Directory of Open Access Journals (Sweden)

    Tiefeng Zhang

    2010-10-01

    Full Text Available The evaluation of solutions is an important phase in power distribution system planning (PDSP which allows issues such as quality of supply, cost, social service and environmental implications to be considered and usually involves the judgments of a group of experts. The planning problem is thus suitable for the multi-criteria group decision-making (MCGDM method. The evaluation process and evaluation criteria often involve uncertainties incorporated in quantitative analysis with crisp values and qualitative judgments with linguistic terms; therefore, fuzzy sets techniques are applied in this study. This paper proposes a fuzzy multi-criteria group decision-making (FMCGDM method for PDSP evaluation and applies a fuzzy multi-criteria group decision support system (FMCGDSS to support the evaluation task. We introduce a PDSP evaluation model, which has evaluation criteria within three levels, based on the characteristics of a power distribution system. A case-based example is performed on a test distribution network and demonstrates how all the problems in a PDSP evaluation are addressed using FMCGDSS. The results are acceptable to expert evaluators.

  10. Planning focus group interviews with asylum seekers: Factors related to the researcher, interpreter and asylum seekers.

    Science.gov (United States)

    Eklöf, Niina; Hupli, Maija; Leino-Kilpi, Helena

    2017-10-01

    The aim of this article was to discuss factors related to the researcher, interpreter and asylum seekers when planning focus group interviews with asylum seekers. Focus group interview is one of the basic data collection methods in descriptive nursing and health research. It has been used in multicultural research, allowing an opportunity to participate without literacy and to have linguistic and cultural support from other participants. Asylum seekers form a specific, vulnerable group, and the growing number of asylum seekers increases the need for research related to them. A culturally, methodologically and ethically high-quality focus group interview is based on the researcher's special knowledge and skills, acknowledgement of asylum seekers as both individuals and part of cultural and communal groups, and careful planning of the interpreter's role during the interviews. © 2017 John Wiley & Sons Ltd.

  11. Removal of floating organic in Hanford Waste Tank 241-C-103 restart plan

    International Nuclear Information System (INIS)

    Wilson, T.R.; Hanson, C.

    1994-01-01

    The decision whether or not to remove the organic layer from Waste Tank 241-C-103 was deferred until May, 1995. The following restart plan was prepared for removal of the organic if the decision is to remove the organic from the waste tank 241-C-103

  12. Removal of floating organic in Hanford Waste Tank 241-C-103 restart plan

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, T.R.; Hanson, C.

    1994-10-03

    The decision whether or not to remove the organic layer from Waste Tank 241-C-103 was deferred until May, 1995. The following restart plan was prepared for removal of the organic if the decision is to remove the organic from the waste tank 241-C-103.

  13. Rhizobia with 16S rRNA and nifH similar to Mesorhizobium huakuii but Novel recA, glnII, nodA and nodC genes are symbionts of New Zealand Carmichaelinae.

    Directory of Open Access Journals (Sweden)

    Heng Wee Tan

    Full Text Available New Zealand became geographically isolated about 80 million years ago and this separation gave rise to a unique native flora including four genera of legume, Carmichaelia, Clianthus and Montigena in the Carmichaelinae clade, tribe Galegeae, and Sophora, tribe Sophoreae, sub-family Papilionoideae. Ten bacterial strains isolated from NZ Carmichaelinae growing in natural ecosystems grouped close to the Mesorhizobium huakuii type strain in relation to their 16S rRNA and nifH gene sequences. However, the ten strains separated into four groups on the basis of their recA and glnII sequences: all groups were clearly distinct from all Mesorhizobium type strains. The ten strains separated into two groups on the basis of their nodA sequences but grouped closely together in relation to nodC sequences; all nodA and nodC sequences were novel. Seven strains selected and the M. huakuii type strain (isolated from Astragalus sinicus produced functional nodules on Carmichaelia spp., Clianthus puniceus and A. sinicus but did not nodulate two Sophora species. We conclude that rhizobia closely related to M. huakuii on the basis of 16S rRNA and nifH gene sequences, but with variable recA and glnII genes and novel nodA and nodC genes, are common symbionts of NZ Carmichaelinae.

  14. Scattering of alpha particles from /sup 12/C and the /sup 12/C(. cap alpha. ,. gamma. )/sup 16/O stellar reaction rate

    Energy Technology Data Exchange (ETDEWEB)

    Plaga, R.; Becker, H.W.; Redder, A.; Rolfs, C.; Trautvetter, H.P.; Langanke, K.

    1987-04-06

    The elastic scattering of alpha particles from /sup 12/C has been investigated for 35 angles in the range theta/sub lab/ = 22/sup 0/ to 163/sup 0/ and for 51 energies at E/sub ..cap alpha../ = 1.0 to 6.6 MeV. The extracted phase shifts for l=0 to 6 partial waves have been parametrized in terms of the multilevel R-matrix formalism. Information on the deduced parameters of states in /sup 16/O is reported. The data reveal reduced ..cap alpha..-particle widths for the 6.92 and 7.12 MeV subthreshold states consistent with recent work. The implications for the stellar reaction rate of /sup 12/C(..cap alpha..,..gamma..)/sup 16/O are discussed.

  15. Some Remarks on Group Bundles and C*-dynamical systems

    OpenAIRE

    Vasselli, Ezio

    2003-01-01

    We introduce the notion of fibred action of a group bundle on a C(X)-algebra. By using such a notion, a characterization in terms of induced C*-bundles is given for C*-dynamical systems such that the relative commutant of the fixed-point algebra is minimal (i.e., it is generated by the centre of the given C*-algebra and the centre of the fixed-point algebra). A class of examples in the setting of the Cuntz algebra is given, and connections with superselection structures with nontrivial centre...

  16. Corrective action investigation plan: Area 2 Photo Skid 16 Wastewater Pit, Corrective Action Unit 332. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-01-01

    This Corrective Action Investigation Plan (CAIP) contains a detailed description and plan for an environmental investigation of the Area 2 Photo Skid 16 Wastewater Pit. The site is located in Area 2 of the Nevada Test Site. The Photo Skid Wastewater Pit was used for disposal of photochemical process waste, and there is a concern that such disposal may have released photochemicals and metals to the soil beneath the pit and adjacent to it. The purpose of this investigation is to identify the presence and nature of contamination present in and adjacent to the wastewater pit and to determine the appropriate course of environmental response action for the site. The potential courses of action for the site are clean closure through remediation, closure in place (with or without remediation), or no further action.

  17. 29 CFR 1955.16 - Time.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Time. 1955.16 Section 1955.16 Labor Regulations Relating to...) PROCEDURES FOR WITHDRAWAL OF APPROVAL OF STATE PLANS Notice of Formal Proceeding § 1955.16 Time. Computation of any period of time under these rules shall begin with the first business day following that on...

  18. Group differences in the aesthetic evaluation of nature development plans : A multilevel approach

    NARCIS (Netherlands)

    van den Berg, A.E.; Vlek, CAJ; Coeterier, JF

    The study presented here addresses theoretical, methodological and practical aspects of the issue of group differences in the aesthetic evaluation of natural landscapes. Beauty ratings of an agrarian landscape and five computer simulations of nature development plans in this landscape were collected

  19. Particle-antiparticle pair production in four body reactions in Π+p interaction at 16 GeV/C

    International Nuclear Information System (INIS)

    Amato, S.F.

    1987-01-01

    In this thesis, it was studied experimentally, particle-Antiparticle pair formation, taking into account the partonic Structure of the hadrons. Pair formation such as K + K - , p p - , and Π + Π - at 16 GeV/C was studied using the models based on parton concept. (A.C.A.C.) [pt

  20. Health Workforce Remuneration: comparing wage levels, ranking and dispersion of 16 occupational groups in 20 countries

    NARCIS (Netherlands)

    Tijdens, K.; de Vries, D.H.; Steinmetz, S.

    2013-01-01

    Background This article represents the first attempt to explore remuneration in Human Resources for Health (HRH), comparing wage levels, ranking and dispersion of 16 HRH occupational groups in 20 countries (Argentina, Belarus, Belgium, Brazil, Chile, Colombia, the Czech Republic, Finland, Germany,

  1. Health workforce remuneration: Comparing wage levels, ranking, and dispersion of 16 occupational groups in 20 countries

    NARCIS (Netherlands)

    K.G. Tijdens (Kea); D.H. de Vries (Daniel); S.M. Steinmetz

    2013-01-01

    textabstractBackground: This article represents the first attempt to explore remuneration in Human Resources for Health (HRH), comparing wage levels, ranking and dispersion of 16 HRH occupational groups in 20 countries (Argentina, Belarus, Belgium, Brazil, Chile, Colombia, the Czech Republic,

  2. C-018H Pre-Operational Baseline Sampling Plan

    International Nuclear Information System (INIS)

    Guzek, S.J.

    1993-01-01

    The objective of this task is to field characterize and sample the soil at selected locations along the proposed effluent line routes for Project C-018H. The overall purpose of this effort is to meet the proposed plan to discontinue the disposal of contaminated liquids into the Hanford soil column as described by DOE (1987). Detailed information describing proposed transport pipeline route and associated Kaiser Engineers Hanford Company (KEH) preliminary drawings (H288746...755) all inclusive, have been prepared by KEH (1992). The information developed from field monitoring and sampling will be utilized to characterize surface and subsurface soil along the proposed C-018H effluent pipeline and it's associated facilities. Potentially existing contaminant levels may be encountered therefore, soil characterization will provide a construction preoperational baseline reference, develop personnel safety requirements, and determine the need for any changes in the proposed routes prior to construction of the pipeline

  3. A B2C Digital Media Marketing Communications Plan for a Mobile Application Commercial Launch

    OpenAIRE

    Collin, Markus

    2013-01-01

    The thesis focuses on a B2C Digital Marketing Communications plan on a mobile gamification application. The marketing communications plan takes a clear step away from the traditional views on marketing planning and PR, above all because of the evolvement of social media and the massive cultural shift that has deeply affected the way societies use the most widely spread communications platform ever invented, the Internet. The project for which the marketing communications plan is made, is ...

  4. IMRT commissioning: Multiple institution planning and dosimetry comparisons, a report from AAPM Task Group 119

    Energy Technology Data Exchange (ETDEWEB)

    Ezzell, Gary A.; Burmeister, Jay W.; Dogan, Nesrin [Department of Radiation Oncology, Mayo Clinic Scottsdale, 5777 East Mayo Boulevard, MCSB Concourse, Phoenix, Arizona 89054 (United States); and others

    2009-11-15

    AAPM Task Group 119 has produced quantitative confidence limits as baseline expectation values for IMRT commissioning. A set of test cases was developed to assess the overall accuracy of planning and delivery of IMRT treatments. Each test uses contours of targets and avoidance structures drawn within rectangular phantoms. These tests were planned, delivered, measured, and analyzed by nine facilities using a variety of IMRT planning and delivery systems. Each facility had passed the Radiological Physics Center credentialing tests for IMRT. The agreement between the planned and measured doses was determined using ion chamber dosimetry in high and low dose regions, film dosimetry on coronal planes in the phantom with all fields delivered, and planar dosimetry for each field measured perpendicular to the central axis. The planar dose distributions were assessed using gamma criteria of 3%/3 mm. The mean values and standard deviations were used to develop confidence limits for the test results using the concept confidence limit=|mean|+1.96{sigma}. Other facilities can use the test protocol and results as a basis for comparison to this group. Locally derived confidence limits that substantially exceed these baseline values may indicate the need for improved IMRT commissioning.

  5. 75 FR 18482 - Stanford University Habitat Conservation Plan

    Science.gov (United States)

    2010-04-12

    ... Library, 1213 Newell Road, Palo Alto, CA 94303. Individuals wishing copies of the DEIS, Plan, or IA should... threatened (16 U.S.C. 1538). The term ''take'' means to harass, harm, pursue, hunt, shoot, wound, kill, trap... significant habitat modification or degradation that actually kills or injures listed wildlife by...

  6. Greater-Than-Class C Low-Level Radioactive Waste Transportation Strategy report and institutional plan

    Energy Technology Data Exchange (ETDEWEB)

    Schmitt, R.C.; Tyacke, M.J.

    1995-01-01

    This document contains two parts. Part I, Greater-Than-Class-C Low-Level Radioactive Waste Transportation Strategy, addresses the requirements, responsibilities, and strategy to transport and receive these wastes. The strategy covers (a) transportation packaging, which includes shipping casks and waste containers; (b) transportation operations relating to the five facilities involved in transportation, i.e., waste originator, interim storage, dedicated storage, treatment, and disposal; (c) system safety and risk analysis; (d) routes; (e) emergency preparedness and response; and (o safeguards and security. A summary of strategic actions is provided at the conclusion of Part 1. Part II, Institutional Plan for Greater-Than-Class C Low-Level Radioactive Waste Packaging and Transportation, addresses the assumptions, requirements, and institutional plan elements and actions. As documented in the Strategy and Institutional Plan, the most challenging issues facing the GTCC LLW Program shipping campaign are institutional issues closely related to the strategy. How the Program addresses those issues and demonstrates to the states, local governments, and private citizens that the shipments can and will be made safely will strongly affect the success or failure of the campaign.

  7. Greater-Than-Class C Low-Level Radioactive Waste Transportation Strategy report and institutional plan

    International Nuclear Information System (INIS)

    Schmitt, R.C.; Tyacke, M.J.

    1995-01-01

    This document contains two parts. Part I, Greater-Than-Class-C Low-Level Radioactive Waste Transportation Strategy, addresses the requirements, responsibilities, and strategy to transport and receive these wastes. The strategy covers (a) transportation packaging, which includes shipping casks and waste containers; (b) transportation operations relating to the five facilities involved in transportation, i.e., waste originator, interim storage, dedicated storage, treatment, and disposal; (c) system safety and risk analysis; (d) routes; (e) emergency preparedness and response; and (o safeguards and security. A summary of strategic actions is provided at the conclusion of Part 1. Part II, Institutional Plan for Greater-Than-Class C Low-Level Radioactive Waste Packaging and Transportation, addresses the assumptions, requirements, and institutional plan elements and actions. As documented in the Strategy and Institutional Plan, the most challenging issues facing the GTCC LLW Program shipping campaign are institutional issues closely related to the strategy. How the Program addresses those issues and demonstrates to the states, local governments, and private citizens that the shipments can and will be made safely will strongly affect the success or failure of the campaign

  8. Multipolarity analysis for 14C high-energy resonance populated by (18O,16O) two-neutron transfer reaction

    International Nuclear Information System (INIS)

    Carbone, D.; Cavallaro, M.; Bondì, M.; Agodi, C.; Cunsolo, A.; Cappuzzello, F.; Azaiez, F.; Franchoo, S.; Khan, E.; Bonaccorso, A.; Fortunato, L.; Foti, A.; Linares, R.; Lubian, J.; Scarpaci, J. A.; Vitturi, A.

    2015-01-01

    The 12 C( 18 O, 16 O) 14 C reaction at 84 MeV incident energy has been explored up to high excitation energy of the residual nucleus thanks to the use of the MAGNEX spectrometer to detect the ejectiles. In the region above the two-neutron separation energy, a resonance has been observed at 16.9 MeV. A multipolarity analysis of the cross section angular distribution indicates an L = 0 character for such a transition

  9. The effect of a 6-week land and resistance training of 13-16 years old swimmers groups to lower limb isokinetic strength values and to swimming performance13-16 yaş grubu yüzücülerde 6 haftalık kara ve direnç antrenmanlarının alt ekstremite izokinetik kuvvet performansına ve yüzme derecelerine etkisi

    OpenAIRE

    Yapıcı, Ayşegül; Maden, Barış; Fındıkoğlu, Gülin

    2016-01-01

    The aim of this study is to investigate the effect of a 6-week land and resistance training of 13-16 year old swimmers groups to lower limb isokinetic strength values and to swimming performance. 22 swimmers participated in this study. The subjects were divided into three groups (A-B-C) according to their 50m swimming degrees. 25m underwater,25m,50m,75m and 100m freestyle swimming degrees of swimmers were recorded. As isokinetic measurements was applied at 60°/s,180°/s and 240°/s speed and th...

  10. The Power of Urban Planning on Environmental Sustainability: A Focus Group Study in Finland

    Directory of Open Access Journals (Sweden)

    Eeva-Sofia Säynäjoki

    2014-09-01

    Full Text Available Sustainable communities are promoted as a desirable policy goal and, in particular, local authorities are encouraged to contribute to climate change mitigation through urban planning. Furthermore, recent research takes a broad perspective on the environmental sustainability of urban areas and considers the environmental impact of all consumption. A focus group study was conducted in Finland for the purpose of examining how increased environmental awareness influences urban land use. The 32 participants of three focus groups were professionals of urban planning and environmental sustainability, at both a municipal and a state level. The main finding was that urban planning is viewed as being unable to support environmental sustainability in the broader sense. In general, the participants did not see a connection between urban structure and sustainable lifestyles and only the influence of planning on housing and daily journeys was recognised. Three main reasons for this were identified. Firstly, environmental sustainability in its broader definition is seen as too complex for urban planners to influence alone. Secondly, the dominance of short-term economic issues in decision-making and the lack of co-operation from other stakeholders to achieve environmental aims demotivate land use planners. Thirdly, the prioritisation of urban density may overrule alternative means of promoting environmental sustainability, such as the encouragement of sustainable suburban or non-urban lifestyles.

  11. Radiation therapy planning for early-stage Hodgkin lymphoma

    DEFF Research Database (Denmark)

    Maraldo, Maja V; Dabaja, Bouthaina S; Filippi, Andrea R

    2015-01-01

    PURPOSE: Early-stage Hodgkin lymphoma (HL) is a rare disease, and the location of lymphoma varies considerably between patients. Here, we evaluate the variability of radiation therapy (RT) plans among 5 International Lymphoma Radiation Oncology Group (ILROG) centers with regard to beam arrangements...... axillary disease, and 1 had disease in the neck only. The median age at diagnosis was 34 years (range, 21-74 years), and 5 patients were male. Of the resulting 50 treatment plans, 15 were planned with volumetric modulated arc therapy (1-4 arcs), 16 with intensity modulated RT (3-9 fields), and 19 with 3...

  12. Proposed plan for the Tank 105-C Hazardous Waste Management Facility. Revision 1

    International Nuclear Information System (INIS)

    Miles, W.C. Jr.

    1994-01-01

    This Proposed Plan was developed to describe the remedial action selected at the Tank 105-C Hazardous Waste Management Facility (HWMF) source-specific unit within the C-Area Fundamental Study Area (FSA) at the Savannah River Site (SRS) and to fulfill Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) requirements. This 8,400 gallon capacity tank was certified and accepted closed according to a closure plan approved by the state of South Carolina under the Resource Conservation and Recovery Act (RCRA) authority in January 1991. As a result of the closure, previously performed under RCRA, the unit poses no current or potential threat to human health or the environment. Accordingly, no further remedial action is necessary under CERCLA

  13. High Performance Liquid Chromatographic Analysis of Phytoplankton Pigments Using a C16-Amide Column

    Science.gov (United States)

    A reverse-phase high performance liquid chromatographic (RP-HPLC) method was developed to analyze in a single run, most polar and non-polar chlorophylls and carotenoids from marine phytoplankton. The method is based on a RP-C16-Amide column and a ternary gradient system consistin...

  14. Two-body hypercharge-exchange reactions in K-p and π+p interactions at 10 and 16 GeV/c

    International Nuclear Information System (INIS)

    Girtler, P.; Otter, G.; Sliwa, K.; Barnham, K.W.J.; Eason, R.M.; Newham, P.; Pollock, B.; Wells, J.; Mandl, F.; Markytan, M.

    1979-01-01

    Cross section values or upper limits are presented for twenty-five two-body hypercharge-exchange reactions in K - p and π + p interactions at 10 and 16 GeV/c. The 16 GeV/c results are compared with some predictions of line-reversal plus exchange-degenerate Regge poles, of SU(3) and of the additive quark model. Agreement is found in all cases. (author)

  15. RCNP E398 {sup 16}O,{sup 12}C(p,p’) experiment: Measurement of the γ-ray emission probability from giant resonances in relation to {sup 16}O,{sup 12}C(ν,ν’) reactions

    Energy Technology Data Exchange (ETDEWEB)

    Ou, I.; Yamada, Y.; Mori, T.; Yano, T.; Sakuda, M. [Department of Physics, Okayama University, Okayama 700-8530 (Japan); Tamii, A.; Suzuki, T.; Yosoi, M.; Aoi, N.; Ideguchi, E.; Hashimoto, T.; Miki, K.; Ito, T.; Iwamoto, C.; Yamamoto, T. [Research Center for Nuclear Physics (RCNP), Osaka University, Ibaraki, Osaka 567-0047 (Japan); Akimune, H. [Department of Physics, Konan University, Okamoto 8-9-1, Higashinada, Kobe 658-8501 (Japan)

    2015-05-15

    We propose to measure the γ-ray emission probability from excited states above 5 MeV including giant resonance of {sup 16}O and {sup 12}C as a function of excitation energy in 1-MeV step. Here, we measure both the excitation energy (E{sub x}=5-30MeV) at the forward scattering angles (0°-3°) of the {sup 16}O, {sup 12}C (p, p’) reaction using Grand-Raiden Spectrometer and the energy of γ-rays (E{sub γ}) using an array of NaI(Tl) counters. The purpose of the experiment is to provide the basic and important information not only for the γ-ray production from primary neutral-current neutrino-oxygen (-carbon) interactions but also for that from the secondary hadronic (neutron-oxygen and -carbon) interactions.

  16. LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.

    Directory of Open Access Journals (Sweden)

    Maikel Jongsma

    Full Text Available Lysophosphatidic acid (LPA, a lipid mediator enriched in serum, stimulates cell migration, proliferation and other functions in many cell types. LPA acts on six known G protein-coupled receptors, termed LPA(1-6, showing both overlapping and distinct signaling properties. Here we show that, unexpectedly, LPA and serum almost completely inhibit the transwell migration of B16 melanoma cells, with alkyl-LPA(18:1 being 10-fold more potent than acyl-LPA(18:1. The anti-migratory response to LPA is highly polarized and dependent on protein kinase A (PKA but not Rho kinase activity; it is associated with a rapid increase in intracellular cAMP levels and PIP3 depletion from the plasma membrane. B16 cells express LPA(2, LPA(5 and LPA(6 receptors. We show that LPA-induced chemorepulsion is mediated specifically by the alkyl-LPA-preferring LPA(5 receptor (GPR92, which raises intracellular cAMP via a noncanonical pathway. Our results define LPA(5 as an anti-migratory receptor and they implicate the cAMP-PKA pathway, along with reduced PIP3 signaling, as an effector of chemorepulsion in B16 melanoma cells.

  17. Novel C16orf57 mutations in patients with Poikiloderma with Neutropenia: bioinformatic analysis of the protein and predicted effects of all reported mutations

    Directory of Open Access Journals (Sweden)

    Colombo Elisa A

    2012-01-01

    Full Text Available Abstract Background Poikiloderma with Neutropenia (PN is a rare autosomal recessive genodermatosis caused by C16orf57 mutations. To date 17 mutations have been identified in 31 PN patients. Results We characterize six PN patients expanding the clinical phenotype of the syndrome and the mutational repertoire of the gene. We detect the two novel C16orf57 mutations, c.232C>T and c.265+2T>G, as well as the already reported c.179delC, c.531delA and c.693+1G>T mutations. cDNA analysis evidences the presence of aberrant transcripts, and bioinformatic prediction of C16orf57 protein structure gauges the mutations effects on the folded protein chain. Computational analysis of the C16orf57 protein shows two conserved H-X-S/T-X tetrapeptide motifs marking the active site of a two-fold pseudosymmetric structure recalling the 2H phosphoesterase superfamily. Based on this model C16orf57 is likely a 2H-active site enzyme functioning in RNA processing, as a presumptive RNA ligase. According to bioinformatic prediction, all known C16orf57 mutations, including the novel mutations herein described, impair the protein structure by either removing one or both tetrapeptide motifs or by destroying the symmetry of the native folding. Finally, we analyse the geographical distribution of the recurrent mutations that depicts clusters featuring a founder effect. Conclusions In cohorts of patients clinically affected by genodermatoses with overlapping symptoms, the molecular screening of C16orf57 gene seems the proper way to address the correct diagnosis of PN, enabling the syndrome-specific oncosurveillance. The bioinformatic prediction of the C16orf57 protein structure denotes a very basic enzymatic function consistent with a housekeeping function. Detection of aberrant transcripts, also in cells from PN patients carrying early truncated mutations, suggests they might be translatable. Tissue-specific sensitivity to the lack of functionally correct protein accounts for the

  18. Quality assurance plan for Waste Area Grouping 6 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    International Nuclear Information System (INIS)

    1994-01-01

    This Quality Assurance Plan (QAP) is concerned with design and construction (Sect. 2) and characterization and monitoring (Sect. 3). The basis for Sect. 2 is the Quality Assurance Plan for the Design and Construction of Waste Area Grouping 6 Closure at Oak Ridge National Laboratory, Oak Ridge, Tennessee, and the basis for Sect. 3 is the Environmental Restoration Quality Program Plan. Combining the two areas into one plan gives a single, overall document that explains the requirements and from which the individual QAPs and quality assurance project plans can be written. The Waste Area Grouping (WAG) 6 QAP establishes the procedures and requirements to be implemented for control of quality-related activities for the WAG 6 project. Quality Assurance (QA) activities are subject to requirements detailed in the Martin Marietta Energy Systems, Inc. (Energy Systems), QA Program and the Environmental Restoration (ER) QA Program, as well as to other quality requirements. These activities may be performed by Energy Systems organizations, subcontractors to Energy Systems, and architect-engineer (A-E) under prime contract to the US Department of Energy (DOE), or a construction manager under prime contract to DOE. This plan specifies the overall Energy Systems quality requirements for the project. The WAG 6 QAP will be supplemented by subproject QAPs that will identify additional requirements pertaining to each subproject

  19. Changes in global gene expression profiles induced by HPV 16 E6 oncoprotein variants in cervical carcinoma C33-A cells

    International Nuclear Information System (INIS)

    Zacapala-Gómez, Ana Elvira; Del Moral-Hernández, Oscar; Villegas-Sepúlveda, Nicolás; Hidalgo-Miranda, Alfredo; Romero-Córdoba, Sandra Lorena

    2016-01-01

    We analyzed the effects of the expression of HPV 16 E6 oncoprotein variants (AA-a, AA-c, E-A176/G350, E-C188/G350, E-G350), and the E-Prototype in global gene expression profiles in an in vitro model. E6 gene was cloned into an expression vector fused to GFP and was transfected in C33-A cells. Affymetrix GeneChip Human Transcriptome Array 2.0 platform was used to analyze the expression of over 245,000 coding transcripts. We found that HPV16 E6 variants altered the expression of 387 different genes in comparison with E-Prototype. The altered genes are involved in cellular processes related to the development of cervical carcinoma, such as adhesion, angiogenesis, apoptosis, differentiation, cell cycle, proliferation, transcription and protein translation. Our results show that polymorphic changes in HPV16 E6 natural variants are sufficient to alter the overall gene expression profile in C33-A cells, explaining in part the observed differences in oncogenic potential of HPV16 variants. - Highlights: • Amino acid changes in HPV16 E6 variants modulate the transciption of specific genes. • This is the first comparison of global gene expression profile of HPV 16 E6 variants. • Each HPV 16 E6 variant appears to have its own molecular signature.

  20. Changes in global gene expression profiles induced by HPV 16 E6 oncoprotein variants in cervical carcinoma C33-A cells

    Energy Technology Data Exchange (ETDEWEB)

    Zacapala-Gómez, Ana Elvira, E-mail: zak_ana@yahoo.com.mx [Laboratorio de Biomedicina Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Gro., México (Mexico); Del Moral-Hernández, Oscar, E-mail: odelmoralh@gmail.com [Laboratorio de Biomedicina Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Gro., México (Mexico); Villegas-Sepúlveda, Nicolás, E-mail: nvillega@cinvestav.mx [Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México, D.F., México (Mexico); Hidalgo-Miranda, Alfredo, E-mail: ahidalgo@inmegen.gob.mx [Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica (INMEGEN), México, D.F., México (Mexico); Romero-Córdoba, Sandra Lorena, E-mail: sromero_cordoba@hotmail.com [Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica (INMEGEN), México, D.F., México (Mexico); and others

    2016-01-15

    We analyzed the effects of the expression of HPV 16 E6 oncoprotein variants (AA-a, AA-c, E-A176/G350, E-C188/G350, E-G350), and the E-Prototype in global gene expression profiles in an in vitro model. E6 gene was cloned into an expression vector fused to GFP and was transfected in C33-A cells. Affymetrix GeneChip Human Transcriptome Array 2.0 platform was used to analyze the expression of over 245,000 coding transcripts. We found that HPV16 E6 variants altered the expression of 387 different genes in comparison with E-Prototype. The altered genes are involved in cellular processes related to the development of cervical carcinoma, such as adhesion, angiogenesis, apoptosis, differentiation, cell cycle, proliferation, transcription and protein translation. Our results show that polymorphic changes in HPV16 E6 natural variants are sufficient to alter the overall gene expression profile in C33-A cells, explaining in part the observed differences in oncogenic potential of HPV16 variants. - Highlights: • Amino acid changes in HPV16 E6 variants modulate the transciption of specific genes. • This is the first comparison of global gene expression profile of HPV 16 E6 variants. • Each HPV 16 E6 variant appears to have its own molecular signature.

  1. Women's status and family planning: results from a focus group survey.

    Science.gov (United States)

    Gu, B; Xie, Z

    1994-02-01

    Focus group discussions were conducted in China's Pingluo County, Ningxia Hui Autonomous Region, and Sihui County, Guangdong Province among reproductive age women with only daughters, mothers-in-law, unmarried women aged 23 years and older, and women business persons and cadres. The topic of discussion was the status of women, gender differences in employment, education, marriage, family life, childbearing, and elderly care in counties that have above average fertility rates. There were also several groups of men, mixed gender groups with husbands working away from home, local family planning workers, and rural intellectuals. The findings showed that there is more access to education for girls and a higher employment rate for young women. Daughters receive education to the highest level affordable. Enrollments are equal for boys and girls. Women's employment is not challenged by husbands, and work is available in a variety of locations. Business ownership and operation is encouraged. By middle age, women generally do not work in enterprises, but at home or on contracted farmland. Equal rights within the family are generally accepted. Husbands turn over their salary to wives for family expenses. Girls receive the same care after birth as boys. Women's status is improving. Improvements in social status have also involved sacrifices. Women complained that the workload on the farm has increased with adult males away working in cities. Women bear the burden of family planning, including in some cases side effects from oral pills and recovery from sterilizations. One women remarked that there were burdens in bearing children, taking oral pills, having IUD insertions, and having induced abortions; men should bear 50% of the responsibility. The burden of women without sons is harder, and women may also feel inferior as the last in their family line. One family with 6 daughters accepted the fine of RMB 7000 yuan for having another child, which turned out to be a son. One

  2. Study of C13/C12 and O18/O16 variations on environments of beach rocks formation in Itaparica island - Bahia

    International Nuclear Information System (INIS)

    Campos, H.S.

    1976-01-01

    Calcium carbonate-cemented beach sands or beach rocks have been observed to occur in the inter tidal zone of many tropical beaches. Near Salvador (Brazil) occurrences are found in several locations on the island of Itaparica. A study of the stable isotope composition (C 13 / C 12 and O 18 / O 16 ) of the cement and the local groundwater was carried out to determine the origin of the carbonate cement. (author)

  3. A working plan for working group 2 'enrichment' within the scope of INFCE

    International Nuclear Information System (INIS)

    1977-01-01

    A working plan for INFCE/WG.2 is presented, outlining the major questions which the group needs to answer under the headings: 1. Enrichment needs and supply, 2. Models for cross-investment, 3. Market situation, 4. Technical and economic assessment of the different enrichment technologies, and 5. Safeguards aspects. It is suggested that the group's assessment should include: 1. Future enrichment capacities, 2. Multinational or regional fuel cycle centres, 3. Possible patterns for guarantees of supply, and 4. Special needs of developing countries

  4. Factors affecting unmet need for family planning in married women of reproductive age group in urban slums of Lucknow

    Directory of Open Access Journals (Sweden)

    Anjali Pal

    2014-03-01

    Full Text Available Background: Unmet need for family planning signifies the gap between the reproductive intentions of couples and their actual contraceptive behaviour. The National Family Health Surveys carried out in India in 1992-93, 1998-99 and 2004-2005 have revealed that for a sizable proportion of the population in the reproductive age group, the need for contraceptive services are not met with despite the existence of a National Policy on family planning since 1983. This study was carried out to assess the extent of unmet need for family planning among married women of reproductive age group in urban slums of Lucknow and identify the various factors affecting it. Study design: Cross sectional Setting: four urban slums of Lucknow Participants: 414 married women in the age group of 15- 44 years Study variables: age, education, occupation, religion, parity Statistical analysis: chi- square test, logistic regression analysis, fisher’s exact test Results: the extent of unmet need among married women of reproductive age group was 53.1%. The unmet need was found to be significantly associated with age, number of living sons, discussion of family planning with husband, perception of husband’s view on family planning and husbands’ behaviour towards use of family planning method. Logistic regression analysis of unmet need showed that the lower age of the woman, lesser number of living sons and husband’s discouragement towards the use of FP method were correlated with the unmet need for Family Planning.

  5. Does elimination of planned postoperative radiation to the primary bed in p16-positive, transorally-resected oropharyngeal carcinoma associate with poorer outcomes?

    Science.gov (United States)

    Sinha, Parul; Pipkorn, Patrik; Thorstad, Wade L; Gay, Hiram A; Haughey, Bruce H

    2016-10-01

    The purpose of our study is to compare oncologic and functional outcomes of p16-positive oropharyngeal squamous cell carcinoma (OPSCC) patients, in the presence and absence of planned radiation to the primary bed following transoral surgery (TOS), stratified by T-classification. Retrospective cohort study of 261, T1-T4, consecutively TOS-treated OPSCC patients. At a median follow-up of 61months, local recurrence (LR) occurred in 6 (2.3%)patients (3 each in T1-T2 and T3-T4 groups), of which 5 had tumors in the tongue base and one in the tonsil. Of patients not receiving planned primary bed radiation, LR occurred in 3% of T1-T2s versus 17% of T3-T4s. In patients with T1-T2 tumors, Absolute Risk Reduction of LR with primary bed radiation was 3.26% (95% CI: -0.37%, 7%); Number Needed to Treat to prevent one LR was 31 (95% CI: 14.5, 271). Absolute Risk Increase for gastrostomy-tube with primary bed radiation was 34.4% (95% CI: 24%, 45%); Number Needed to Harm was 3 (95% CI: 2.2, 4.2), i.e., for every three patients with T1-T2 tumors receiving primary bed radiation, one had a gastrostomy-tube. Elimination of primary bed radiation in margin-negative resected, T1-T2 p16-positive OPSCC was not associated with significant compromise of local control, and correlated with superior swallowing preservation, assessed using gastrostomy rate as a surrogate. Lack of primary bed radiation in T3-T4 tumors associated with significantly increased LR rates. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Indiana University High Energy Physics Group, Task C

    International Nuclear Information System (INIS)

    Bower, C.; Heinz, R.; Mufson, S.; Musser, J.

    1993-01-01

    The Indiana University Task C group is participating in the experiments GEM at the SSC and MACRO at the Gran Sasso. After an introduction to GEM in paragraph II, a detailed report is presented on the work done during the current contract period on the design of the outer region of the GEM Central Tracker. The Central Tracker Monte Carlo, which was the other significant GEM activity by the group, is included. In paragraph III is introduced MACRO and a brief status report is given. Muon Astronomy analysis done using MACRO data is also presented

  7. Project management plan for the 105-C Reactor interim safe storage project. Revision 1

    International Nuclear Information System (INIS)

    Miller, R.L.

    1997-01-01

    In 1942, the Hanford Site was commissioned by the US Government to produce plutonium. Between 1942 and 1955, eight water-cooled, graphite-moderated reactors were constructed along the Columbia River at the Hanford Site to support the production of plutonium. The reactors were deactivated from 1964 to 1971 and declared surplus. The Surplus Production Reactor Decommissioning Project (BHI 1994b) will decommission these reactors and has selected the 105-C Reactor to be used as a demonstration project for interim safe storage at the present location and final disposition of the entire reactor core in the 200 West Area. This project will result in lower costs, accelerated schedules, reduced worker exposure, and provide direct benefit to the US Department of Energy for decommissioning projects complex wide. This project sets forth plans, organizational responsibilities, control systems, and procedures to manage the execution of the Project Management Plan for the 105-C Reactor Interim Safe Storage Project (Project Management Plan) activities to meet programmatic requirements within authorized funding and approved schedules. The Project Management Plan is organized following the guidelines provided by US Department of Energy Order 4700.1, Project Management System and the Richland Environmental Restoration Project Plan (DOE-RL 1992b)

  8. Fourier Transform Spectroscopy of Carbonyl Sulfide from 4800 to 8000 cm -1and New Global Analysis of 16O 12C 32S

    Science.gov (United States)

    Rbaihi, E.; Belafhal, A.; Vander Auwera, J.; Naı̈m, S.; Fayt, A.

    1998-09-01

    We have measured the FT spectrum of natural OCS from 4800 to 8000 cm-1with a near Doppler resolution and a line-position accuracy between 2 and 8 × 10-4cm-1. For the normal isotopic species16O12C32S, 37 vibrational transitions have been analyzed for both frequencies and intensities. We also report six bands of16O12C34S, five bands of16O13C32S, two bands of16O12C33S, and two bands of18O12C32S. Important effective Herman-Wallis terms are explained by the anharmonic resonances between closely spaced states. As those results complete the study of the Fourier transform spectra of natural carbonyl sulfide from 1800 to 8000 cm-1, a new global rovibrational analysis of16O12C32S has been performed. We have determined a set of 148 molecular parameters, and a statistical agreement is obtained with all the available experimental data.

  9. 12C+16O sub-barrier radiative capture cross-section measurements

    International Nuclear Information System (INIS)

    Goasduff, A.; Courtin, S.; Haas, F.; Beck, C.; Lebhertz, D.; Jenkins, D.G.; Fallis, J.; Ruiz, C.; Hutcheon, D.A.; Amandruz, P.A.; Davis, C.; Hager, U.; Ottewell, D.; Ruprecht, G.

    2011-01-01

    We have performed a heavy ion radiative capture reaction between two light heavy ions, 12 C and 16 O, leading to 28 Si. The present experiment has been performed below Coulomb barrier energies in order to reduce the phase space and to try to shed light on structural effects. Obtained γ-spectra display a previously unobserved strong feeding of intermediate states around 11 MeV at these energies. This new decay branch is not fully reproduced by statistical nor semi-statistical decay scenarios and may imply structural effects. Radiative capture cross-sections are extracted from the data. (authors)

  10. Programming 16-Bit PIC Microcontrollers in C Learning to Fly the PIC 24

    CERN Document Server

    Di Jasio, Lucio

    2011-01-01

    New in the second edition: * MPLAB X support and MPLAB C for the PIC24F v3 and later libraries * I2C™ interface * 100% assembly free solutions * Improved video, PAL/NTSC * Improved audio, RIFF files decoding * PIC24F GA1, GA2, GB1 and GB2 support   Most readers will associate Microchip's name with the ubiquitous 8-bit PIC microcontrollers but it is the new 16-bit PIC24F family that is truly stealing the scene. Orders of magnitude increases of performance, memory size and the rich peripheral set make programming these devices in C a must. This new guide by Microchip insid

  11. Two-dimensional intermittency in 16O-Ag/Br interactions at 200 A GeV/c

    International Nuclear Information System (INIS)

    Ghosh, M.K.; Mukhopadhyay, A.; Haldar, P.K.; Manna, S.K.; Singh, G.

    2009-01-01

    The anomalous behavior of 2-dimensional (2D) scaled factorial moments (SFM), calculated over the density distribution of singly charged particles produced in 16 O-Ag/Br interactions at an incident momentum of 200A GeV/c, has been studied

  12. YebU is a m5C methyltransferase specific for 16 S rRNA nucleotide 1407

    DEFF Research Database (Denmark)

    Andersen, Niels Møller; Douthwaite, Stephen

    2006-01-01

    generally require specific enzymes, and only one m5C rRNA methyltransferase, RsmB (formerly Fmu) that methylates nucleotide C967, has previously been identified. BLAST searches of the E.coli genome revealed a single gene, yebU, with sufficient similarity to rsmB to encode a putative m5C RNA...... methyltransferase. This suggested that the yebU gene product modifies C1407 and/or C1962. Here, we analysed the E.coli rRNAs by matrix assisted laser desorption/ionization mass spectrometry and show that inactivation of the yebU gene leads to loss of methylation at C1407 in 16 S rRNA, but does not interfere...

  13. Surveillance and Maintenance Plan for the 105-C Reactor Safe Storage Enclosure

    International Nuclear Information System (INIS)

    Logan, T. E.

    1998-01-01

    This document provides a plan for implementing surveillance and maintenance activities to ensure that the 105-C Reactor Safe Storage Enclosure is maintained in a safe, environmentally secure, and cost-effective manner until subsequent closure during the final disposition phase of decommissioning

  14. Investigation of reactivity between SiC and Nb-1Zr in planned irradiation creep experiments

    Energy Technology Data Exchange (ETDEWEB)

    Lewinsohn, C.A.; Hamilton, M.L.; Jones, R.H.

    1997-08-01

    Thermodynamic calculations and diffusion couple experiments showed that SiC and Nb-1Zr were reactive at the upper range of temperatures anticipated in the planned irradiation creep experiment. Sputter-deposited aluminum oxide (Al{sub 2}O{sub 3}) was selected as a diffusion barrier coating. Experiments showed that although the coating coarsened at high temperature it was an effective barrier for diffusion of silicon from SiC into Nb-1Zr. Therefore, to avoid detrimental reactions between the SiC composite and the Nb-1Zr pressurized bladder during the planned irradiation creep experiment, a coating of Al{sub 2}O{sub 3} will be required on the Nb-1Zr bladder.

  15. Elastic scattering of lithium by 9Be, 10B, 12C, 13C, 16O, and 28Si from 4 to 63 MeV

    International Nuclear Information System (INIS)

    Poling, J.E.; Norbeck, E.; Carlson, R.R.

    1976-01-01

    Elastic scattering angular distributions have been measured at energies between 4.0 and 13.0 MeV for 6 Li and 7 Li beams and targets of 10 B, 12 C, 13 C, 16 O, and 28 Si. Yield curves have been measured for energies from 3.0 to 13.0 MeV for 6 Li beams and targets of 9 Be, 12 C, 13 C, 16 O, and 28 Si, and for 7 Li and 12 C. The angular distributions, supplemented by published angular distributions, have been fitted with optical-model potentials. For 6 Li+ 12 C, angular distributions were available at energies from 4.5 to 63.0 MeV. Potentials which gave fits to the data across the entire available energy range were obtained for each elastic scattering reaction. The usual ambiguities were observed in the optical-model potentials. In certain cases the back angles were not well fitted by parameter sets which were useful for all energies. The quality of the fits did not seem to be limited by experimental errors, which were generally better than 10% for our data; compound nucleus effects are presumed to be the cause of rapid energy variations in the angular distributions

  16. How do wild baboons (Papio ursinus) plan their routes? Travel among multiple high-quality food sources with inter-group competition.

    Science.gov (United States)

    Noser, Rahel; Byrne, Richard W

    2010-01-01

    How do humans and animals travel between multiple destinations on a given foraging trip? This question is of theoretical and practical interest, yet few empirical data exist to date. We examined how a group of wild chacma baboons travelled among multiple, simultaneously fruiting mountain fig trees (Ficus glumosa). In the course of a 16-month study, this highly preferred fruit was available during a 3-week period, from relatively few sites, which were also utilized by four larger baboon groups. We used directness of route and travel speed of 13 days of observation, and approach rates of 31 days of observation to differentiate between purposeful and opportunistic encounters with 50 fig trees. The study group visited a total of 30 fig trees overall, but only 8 trees per day on average. Each morning, they travelled along a highly repetitive route on all days of observation, thereby visiting 2-4 fig trees. They approached these trees rapidly along highly directed paths without intermittently exploiting other food sources that were available in large quantities. Then, they abruptly changed behaviour, switching to lower travel speed and less directed routes as they foraged on a variety of foods. They approached additional fig trees later in the day, but approach rates were similar to those at times of year when fruit of this fig species was unavailable; this suggested that encounters with trees after the behavioural switch were not planned. Comparing visits to purposefully and opportunistically encountered trees, we found no difference in the average time spent feeding or frequency of feeding supplants, suggesting that purposefully and opportunistically visited trees had similar values. We conclude that when foraging for mountain fig fruit the baboons' cognitive maps either contain information on relatively few trees or of only a single route along which several trees are situated, leading to very limited planning abilities.

  17. Operable Unit 3-13, Group 3, Other Surface Soils (Phase II) Field Sampling Plan

    Energy Technology Data Exchange (ETDEWEB)

    G. L. Schwendiman

    2006-07-27

    This Field Sampling Plan describes the Operable Unit 3-13, Group 3, Other Surface Soils, Phase II remediation field sampling activities to be performed at the Idaho Nuclear Technology and Engineering Center located within the Idaho National Laboratory Site. Sampling activities described in this plan support characterization sampling of new sites, real-time soil spectroscopy during excavation, and confirmation sampling that verifies that the remedial action objectives and remediation goals presented in the Final Record of Decision for Idaho Nuclear Technology and Engineering Center, Operable Unit 3-13 have been met.

  18. Individual radiation response of parotid glands investigated by dynamic 11C-methionine PET

    International Nuclear Information System (INIS)

    Buus, Simon; Grau, Cai; Munk, Ole Lajord; Rodell, Anders; Jensen, Kenneth; Mouridsen, Kim; Keiding, Susanne

    2006-01-01

    Background and Purpose: Previously, we showed that the net metabolic clearance of 11 C-methionine of the parotid gland, K, calculated from dynamic 11 C-methionine PET, can be used as a measure of parotid gland function. The aim of this study was to investigate by dynamic 11 C-methionine PET the individual radiation dose response relationship of parotid glands in head and neck cancer patients. Patients and methods: Twelve head and neck cancer patients were examined by dynamic 11 C-methionine PET after radiotherapy. Parametric images of K were generated, co-registered and compared voxel-by-voxel with the 3D radiation dose plan within the parotid gland to assess the individual radiation dose-function relationship. Results: In each patient, voxel-values of K decreased with increasing radiation dose. Population based analysis showed a sigmoid dose response relationship of parotid gland, from which we estimated a threshold radiation dose of 16 Gy and a mean TD 5 of 30 Gy. TD 5 ranged from 7 to 50 Gy in the group of patients. Conclusions: Individual radiation dose response of parotid glands can be measured by dynamic 11 C-methionine PET. The dose response analysis revealed a sigmoid relationship, a threshold radiation dose of 16 Gy, and a mean TD 5 of 30 Gy

  19. [Hepatitis C treatment in special patient groups].

    Science.gov (United States)

    Berenguer, Marina; Jorquera, Francisco; Ángel Serra, Miguel; Sola, Ricard; Castellano, Gregorio

    2014-07-01

    The treatment plan for chronic hepatitis C in special populations varies according to comorbidity and the current evidence on treatment. In patients with hepatitis C virus and HIV coinfection, the results of dual therapy (pegylated interferon plus ribavirin) are poor. In patients with genotype 1 infection, triple therapy (dual therapy plus boceprevir or telaprevir) has doubled the response rate, but protease inhibitors can interact with some antiretroviral drugs and provoke more adverse effects. These disadvantages are avoided by the new, second-generation, direct-acting antiviral agents. In patients who are candidates for liver transplantation or are already liver transplant recipients, the optimal therapeutic option at present is to combine the new antiviral agents, with or without ribavirin and without interferon. The treatment of patients under hemodialysis due to chronic renal disease continues to be dual therapy (often with reduced doses of pegylated interferon and ribavirin), since there is still insufficient information on triple therapy and the new antiviral agents. In mixed cryoglobulinemia, despite the scarcity of experience, triple therapy seems to be superior to dual therapy and may be used as rescue therapy in non-responders to dual therapy. However, a decision must always be made on whether antiviral treatment should be used concomitantly or after immunosuppressive therapy. Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

  20. Contribution to the study of the elastic scattering of the system 16O+12C

    International Nuclear Information System (INIS)

    Charles, Pierre.

    1981-03-01

    It is generally accepted, in the study of elastic scattering of the 16 O+ 12 C system, that each resonance corresponds to an inherent state of the angular momentum. It does not seem satisfactory to attribute an angular momentum to a resonance without having studied the variation in the angular matrix elements at a scattering resonance in terms of the energy. Now, when not one angular distribution, but a set of angular distributions is examined at adjacent energies, the conclusion is reached that a partial wave has no particular behaviour, but that the structures observed are due to a correlation between the different partial waves. The structures observed between 19 MeV and 24 MeV in the centre of mass system (35 to 40 MeV in 28 Si) do not correspond to inherent states of the angular momentum. Then, one must either assume that the total momentum is not a constant of the movement or that the structures observed correspond to groupings of different levels of angular momentum. The phase shift analysis clearly suggests the existence of groupings of levels reflecting the presence of intermediate structures at 36 MeV and 39 MeV in 28 Si. At such an excitation energy, the mean lives of these structures are assumed to be very short and hence the width of the different levels is great with regard to their spacing: this does not make it possible to show up the 'fine structure' of the resonances because, (a) all the resonant partial waves interfere with each other and (b) the continuous coupling introduces a fluctuating part in the scattering amplitude. The exchange process of two 12 C cores is certainly not unimportant and it has been noticed that certain behaviours of the angular distributions are well reproduced when a term depending on the parity is added to the optical potential [fr

  1. C A R A fuel element for Atucha nuclear power plants and development plan

    International Nuclear Information System (INIS)

    Brasnarof, D. O; Marino, A. C; Bianchi, D; Giorgis M A; Orlando, O; Munoz, C; Taboada, H; Florido, P. C

    2006-01-01

    This paper presents the current state and the development plan of the C A R A fuel element.Main activities were carried out towards to welding of the end plates of the C A R A fuel element by a new process, and the assembling and hanging of the C A R A fuel element in its Atucha configuration, by using an external basket [es

  2. Oncogenesis of melanoma B16 cell clones mutagenized by space environment

    International Nuclear Information System (INIS)

    Guo Yupeng; Yang Hongsheng; Tang Jingtian; Xu Mei; Geng Chuanying; Fang Qing; Xu Bo; Li Hongyan; Xiang Xing; Pan Lin

    2005-01-01

    Objective: To explore the oncogenesis of the melanoma B16 cell clones mutagenized by space environment, and find the B16 cell clones with remarkably mutated immunogenicity. Methods: B16 cells were carried by the Chinese 20th recoverable satellite to the outer space, and were harvested after 18 days' spaceflight and then monocloned. Four cell clones, which were randomly selected from the total 110 clones obtained , and the control clone were routinely cultured. The cultured cells were injected to 10 groups of C57BL/6J mice, 82.1 mice in each group. Five groups of mice received hypodermic injection and another 5 groups of mice received abdominal injection. The survival time was observed in abdominal injection groups. The mice in hypodermic injection groups were sacrificed after 14 days, the tumor, spleen and thymus were weighted, and the serum IL-2 concentration was determined. Moreover, the melanoma tumor tissues were examined histopathologically. Results: An experiment program suitable to screening space mutagenesis of B16 tumor cell clones in vivo and the observation indices were basically established. One clone was found out which was remarkably different from the control clone in latent period of tumor formation, tumor weight, survival time of the tumor-bearing mice and the expression of IL-2. Conclusions: Cultured melanoma B16 cells could be mutated by outer space environment. The further study will be focused on the influence of space environment on immunogenicity of mutagenized B16 cells. (authors)

  3. Evaluation procedure of software safety plan for digital I and C of KNGR

    International Nuclear Information System (INIS)

    Lee, Jang Soo; Park, Jong Kyun; Lee, Ki Young; Kwon, Ki Choon; Kim, Jang Yeol; Cheon, Se Woo

    2000-05-01

    The development, use, and regulation of computer systems in nuclear reactor instrumentation and control (I and C) systems to enhance reliability and safety is a complex issue. This report is one of a series of reports from the Korean next generation reactor (KNGR) software safety verification and validation (SSVV) task, Korea Atomic Energy Research Institute, which investigates different aspects of computer software in reactor I and C systems, and describes the engineering procedures for developing such a software. The purpose of this guideline is to give the software safety evaluator the trail map between the code and standards layer and the design methodology and documents layer for the software important to safety in nuclear power plants. Recently, the safety planning for safety-critical software systems is being recognized as the most important phase in the software life cycle, and being developed new regulatory positions and standards by the regulatory and the standardization organizations. The requirements for software important to safety of nuclear reactor are described in such positions and standards, for example, the new standard review plan (SRP), IEC 880 supplements, IEEE standard 1228-1994, IEEE standard 7-4.3.2-1993, and IAEA safety series No. 50-SG-D3 and D8. We presented the guidance for evaluating the safety plan of the software in the KNGR protection systems. The guideline consists of the regulatory requirements for software safety in chapter 2, the evaluation checklist of software safety plan in chapter3, and the evaluation results of KNGR software safety plan in chapter 4

  4. Evaluation procedure of software safety plan for digital I and C of KNGR

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jang Soo; Park, Jong Kyun; Lee, Ki Young; Kwon, Ki Choon; Kim, Jang Yeol; Cheon, Se Woo

    2000-05-01

    The development, use, and regulation of computer systems in nuclear reactor instrumentation and control (I and C) systems to enhance reliability and safety is a complex issue. This report is one of a series of reports from the Korean next generation reactor (KNGR) software safety verification and validation (SSVV) task, Korea Atomic Energy Research Institute, which investigates different aspects of computer software in reactor I and C systems, and describes the engineering procedures for developing such a software. The purpose of this guideline is to give the software safety evaluator the trail map between the code and standards layer and the design methodology and documents layer for the software important to safety in nuclear power plants. Recently, the safety planning for safety-critical software systems is being recognized as the most important phase in the software life cycle, and being developed new regulatory positions and standards by the regulatory and the standardization organizations. The requirements for software important to safety of nuclear reactor are described in such positions and standards, for example, the new standard review plan (SRP), IEC 880 supplements, IEEE standard 1228-1994, IEEE standard 7-4.3.2-1993, and IAEA safety series No. 50-SG-D3 and D8. We presented the guidance for evaluating the safety plan of the software in the KNGR protection systems. The guideline consists of the regulatory requirements for software safety in chapter 2, the evaluation checklist of software safety plan in chapter3, and the evaluation results of KNGR software safety plan in chapter 4.

  5. Directed C-H Bond Oxidation of (+)-Pleuromutilin.

    Science.gov (United States)

    Ma, Xiaoshen; Kucera, Roman; Goethe, Olivia F; Murphy, Stephen K; Herzon, Seth B

    2018-05-01

    Antibiotics derived from the diterpene fungal metabolite (+)-pleuromutilin (1) are useful agents for the treatment Gram-positive infections in humans and farm animals. Pleuromutilins elicit slow rates of resistance development and minimal cross-resistance with existing antibiotics. Despite efforts aimed at producing new derivatives by semisynthesis, modification of the tricyclic core is underexplored, in part due to a limited number of functional group handles. Herein, we report methods to selectively functionalize the methyl groups of (+)-pleuromutilin (1) by hydroxyl-directed iridium-catalyzed C-H silylation, followed by Tamao-Fleming oxidation. These reactions provided access to C16, C17, and C18 monooxidized products, as well as C15/C16 and C17/C18 dioxidized products. Four new functionalized derivatives were prepared from the protected C17 oxidation product. C6 carboxylic acid, aldehyde, and normethyl derivatives were prepared from the C16 oxidation product. Many of these sequences were executed on gram scales. The efficiency and practicality of these routes provides an easy method to rapidly interrogate structure-activity relationships that were previously beyond reach. This study will inform the design of fully synthetic approaches to novel pleuromutilins and underscores the power of the hydroxyl-directed iridium-catalyzed C-H silylation reaction.

  6. A synthetic C16 omega-hydroxyphytoceramide improves skin barrier functions from diversely perturbed epidermal conditions.

    Science.gov (United States)

    Oh, Myoung Jin; Nam, Jin Ju; Lee, Eun Ok; Kim, Jin Wook; Park, Chang Seo

    2016-10-01

    Omega-hydroxyceramides (ω-OH-Cer) play a crucial role in maintaining the integrity of skin barrier. ω-OH-Cer are the primary lipid constituents of the corneocyte lipid envelope (CLE) covalently attached to the outer surface of the cornified envelope linked to involucrin to become bound form lipids in stratum corneum (SC). CLE becomes a hydrophobic impermeable layer of matured corneocyte preventing loss of natural moisturizing factor inside the corneocytes. More importantly, CLE may also play an important role in the formation of proper orientation of intercellular lipid lamellar structure by interdigitating with the intercellular lipids in a comb-like fashion. Abnormal barrier conditions associated with atopic dermatitis but also UVB-irradiated skins are known to have lowered level of bound lipids, especially ω-OH-Cer, which indicate that ω-OH-Cer play an important role in maintaining the integrity of skin barrier. In this study, protective effects of a novel synthetic C16 omega-hydroxyphytoceramides (ω-OH-phytoceramide) on skin barrier function were investigated. Epidermal barrier disruption was induced by UVB irradiation, tape-stripping in hairless mouse and human skin. Protective effect of damaged epidermis was evaluated using the measurement of transepidermal water loss and cohesion of SC. Increased keratinocyte differentiation was verified using cultured keratinocyte through western blot. Results clearly demonstrated that a synthetic C16 ω-OH-phytoceramide enhanced the integrity of SC and accelerated the recovery of damaged skin barrier function by stimulating differentiation process. In a conclusion, a synthetic C16 ω-OH-phytoceramide treatment improved epidermal homeostasis in several disrupted conditions.

  7. INDOT Technical Training Plan : Appendix C

    Science.gov (United States)

    2012-04-01

    The study provides the background documents necessary for the development of a Technical Training Plan and makes recommendations for the content and structure of such a plan for the District Operations, Operations, Capital Program Management, and Eng...

  8. Plan de Auditoría informática para el Grupo El Comercio C.A. con aplicación de la metodología COBIT 4.1

    OpenAIRE

    Bastidas Fierro, Carmen Alezandra

    2014-01-01

    This paper titling called: Plan Audit Computing Group Trade CA, with application of the COBIT 4.1 methodology seeks an audit departments Drafting and Technology using COBIT El presente trabajo de titulación denominado: Plan de Auditoría Informática para Grupo El Comercio C.A., con aplicación de la metodología COBIT 4.1 tiene por objeto realizar una auditoría en los departamentos de Redacción y Tecnología usando COBIT

  9. Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans.

    Science.gov (United States)

    Kumar, Neeraj; Jain, Vaibhav; Singh, Anupama; Jagtap, Urmila; Verma, Sonia; Mukhopadhyay, Arnab

    2015-12-08

    Lowering insulin-IGF-1-like signalling (IIS) activates FOXO transcription factors (TF) to extend life span across species. To study the dynamics of FOXO chromatin occupancy under this condition in C. elegans, we report the first recruitment profile of endogenous DAF-16 and show that the response is conserved. DAF-16 predominantly acts as a transcriptional activator and binding within the 0.5 kb promoter-proximal region results in maximum induction of downstream targets that code for proteins involved in detoxification and longevity. Interestingly, genes that are activated under low IIS already have higher DAF-16 recruited to their promoters in WT. DAF-16 binds to variants of the FOXO consensus sequence in the promoter proximal regions of genes that are exclusively targeted during low IIS. We also define a set of 'core' direct targets, after comparing multiple studies, which tend to co-express and contribute robustly towards IIS-associated phenotypes. Additionally, we show that nuclear hormone receptor DAF-12 as well as zinc-finger TF EOR-1 may bind DNA in close proximity to DAF-16 and distinct TF classes that are direct targets of DAF-16 may be instrumental in regulating its indirect targets. Together, our study provides fundamental insights into the transcriptional biology of FOXO/DAF-16 and gene regulation downstream of the IIS pathway.

  10. Climate signal in d13C of wood lignin methoxyl groups from high-elevation alpine larch trees

    Science.gov (United States)

    Reichelmann, Dana; Greule, Markus; Treydte, Kerstin; Keppler, Frank; Esper, Jan

    2015-04-01

    Tree-rings of high alpine larch trees (Larix decidua) were investigated by a recently established method that measures d13C values of the wood lignin methoxyl groups (Greule et al. 2009). The resulting d13C time series were tested for their potential as a climate proxy. For this 37 larch trees were sampled at the tree line near Simplon Village (Southern Switzerland). They were analysed for their tree-ring width (TRW) and from five individuals d13C of the wood lignin methoxyl groups (d13Cmethoxyl) were measured at annual resolution from 1971-2009 and at pentadal resolution from 1747-2009. The d13Cmethoxyl chronologies were corrected for the anthropogenic change in atmospheric CO2 concentration and its decreasing d13C value. Further, the physiological response of the trees to these atmospheric changes was corrected using the flexible correction factor approach of Treydte et al. (2009), which minimise the residuals with the target climate data. This approach results in the highest so far reported correction factors of 0.032 - 0.036‰/ppmv CO2, which are explained by a low water-use efficiency of deciduous larch. The climate response of the new d13Cmethoxyl proxy shows a significant correlation of 0.75 for the annually and 0.87 for the pentadally resolved data with June to August temperatures. TRW shows also significant correlations with June to August temperatures, but they are lower than the correlations observed for the d13Cmethoxyl chronologies. These results indicate the potential of d13Cmethoxyl chronologies as a summer temperature proxy from high-elevation alpine trees with an even stronger signal than reported from earlier published tree-ring width and maximum latewood density temperature reconstructions. References: Greule, M., Mosandl, A., Hamilton, J.T.G., Keppler, F., 2009. A simple rapid method to precisely determine 13C/12C ratios of plant methoxyl groups. Rapid Communications in Mass Spectrometry, 23(11): 1710-1714. Treydte, K.S., Frank, D.C., Saurer, M

  11. Evaluation plan for a cardiological multi-media workstation (I4C project)

    NARCIS (Netherlands)

    Hofstede, J.W. van der; Quak, A.B.; Ginneken, A.M. van; Macfarlane, P.W.; Watson, J.; Hendriks, P.R.; Zeelenberg, C.

    1997-01-01

    The goal of the I4C project (Integration and Communication for the Continuity of Cardiac Care) is to build a multi-media workstation for cardiac care and to assess its impact in the clinical setting. This paper describes the technical evaluation plan for the prototype.

  12. 26 CFR 1.404(a)-6 - Pension and annuity plans; limitations under section 404(a)(1)(C).

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Pension and annuity plans; limitations under... OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.404(a)-6 Pension and annuity plans; limitations under section 404(a)(1)(C). (a...

  13. The Transcription Factor DAF-16 is Essential for Increased Longevity in C. elegans Exposed to Bifidobacterium longum BB68.

    Science.gov (United States)

    Zhao, Liang; Zhao, Yang; Liu, Ruihai; Zheng, Xiaonan; Zhang, Min; Guo, Huiyuan; Zhang, Hao; Ren, Fazheng

    2017-08-07

    The longevity-promoting benefits of lactobacilli were hypothesized as early as 1907. Although the anti-aging effects of lactic acid bacteria (LAB) have been observed in nematodes, rodents and humans for over a century, the mechanisms underlying the effects of probiotics on aging have rarely been assessed. Using the Caenorhabditis elegans (C. elegans) model, various studies have elucidated the role of different signaling cascades, especially the DAF-16 cascade, on lifespan extension by LAB. In this study, the mechanisms through which Bifidobacterium longum strain BB68 affects the longevity of C. elegans were assessed. The lifespan of nematodes increased by 28% after worms were fed BB68, and this extension of lifespan was completely lost in backgrounds containing a mutated DAF-16 gene. High levels of DAF-16 (in the daf-16 (mu86); muIs61 strain) nuclear accumulation and high expression of the SOD-3 gene (a DAF-16-specific target gene) were observed as a result of BB68 treatment. Immunofluorescence microscopy revealed that TIR-1 and JNK-1 are involved in the phosphorylation and activation of DAF-16. Thus, BB68 increased the longevity of nematodes by activating the TIR-1 - JNK-1 - DAF-16 signaling pathway, and the cell wall component of BB68 contributed to longevity.

  14. Tank 241-C-106 waste retrieval sluicing system process control plan

    Energy Technology Data Exchange (ETDEWEB)

    Carothers, K.G.

    1998-07-25

    Project W-320 has installed the Waste Retrieval Sluicing System at the 200 East Area on the Hanford Site to retrieve the sludge from single-shell tank 241-C-106 and transfer it into double-shell tank 241-AY-102. Operation of the WRSS process will resolve the high-heat safety issue for tank 241-C-106 and demonstrate a technology for the retrieval of single-shell tank wastes. This process control plan coordinates the technical operating requirements (primarily mass transfer, temperature, and flammable gas) for the sluicing operation and provides overall technical guidance for the retrieval activity.

  15. Tank 241-C-106 waste retrieval sluicing system process control plan

    International Nuclear Information System (INIS)

    Carothers, K.G.

    1998-01-01

    Project W-320 has installed the Waste Retrieval Sluicing System at the 200 East Area on the Hanford Site to retrieve the sludge from single-shell tank 241-C-106 and transfer it into double-shell tank 241-AY-102. Operation of the WRSS process will resolve the high-heat safety issue for tank 241-C-106 and demonstrate a technology for the retrieval of single-shell tank wastes. This process control plan coordinates the technical operating requirements (primarily mass transfer, temperature, and flammable gas) for the sluicing operation and provides overall technical guidance for the retrieval activity

  16. Municipal Development Plan, Acerra (Naples

    Directory of Open Access Journals (Sweden)

    Luigi Benevolo

    2014-02-01

    Full Text Available The Municipal Development Plan (Piano Urbanistico Comunale - PUC of Acerra has been drafted by a group of young professionals and researchers, led by Leonardo Benevolo, in accordance with the guidelines laid out by Regional Law no. 16 of 2004. Its complex drafting process was compressed into a brief, nine-month period in 2008 and 2009, at the end of which its initial adoption (or “predisposizione” – “preparation” or “predisposition” – in Italian legal terms was ratified by the municipal council. This article reconstructs the key moments, illustrating the main elements of the plan and how the debate about it took shape both inside and outside the municipal administration.

  17. WE-G-16A-01: Evolution of Radiation Treatment Planning

    International Nuclear Information System (INIS)

    Rothenberg, L; Mohan, R; Van Dyk, J; Fraass, B; Bortfeld, T

    2014-01-01

    Welcome and Introduction - Lawrence N. Rothenberg This symposium is one a continuing series of presentations at AAPM Annual Meetings on the historical aspects of medical physics, radiology, and radiation oncology that have been organized by the AAPM History Committee. Information on previous presentations including “Early Developments in Teletherapy” (Indianapolis 2013), “Historical Aspects of Cross-Sectional Imaging” (Charlotte 2012), “Historical Aspects of Brachytherapy” (Vancouver 2011), “50 Years of Women in Medical Physics” (Houston 2008), and “Roentgen's Early Investigations” (Minneapolis 2007) can be found in the Education Section of the AAPM Website. The Austin 2014 History Symposium will be on “Evolution of Radiation Treatment Planning.” Overview - Radhe Mohan Treatment planning is one of the most critical components in the chain of radiation therapy of cancers. Treatment plans of today contain a wide variety of sophisticated information conveying the potential clinical effectiveness of the designed treatment to practitioners. Examples of such information include dose distributions superimposed on three- or even four-dimensional anatomic images; dose volume histograms, dose, dose-volume and dose-response indices for anatomic structures of interest; etc. These data are used for evaluating treatment plans and for making treatment decisions. The current state-of-the-art has evolved from the 1940s era when the dose to the tumor and normal tissues was estimated approximately by manual means. However, the symposium will cover the history of the field from the late-1950's, when computers were first introduced for treatment planning, to the present state involving the use of high performance computing and advanced multi-dimensional anatomic, functional and biological imaging, focusing only on external beam treatment planning. The symposium will start with a general overview of the treatment planning process including imaging

  18. WE-G-16A-01: Evolution of Radiation Treatment Planning

    Energy Technology Data Exchange (ETDEWEB)

    Rothenberg, L [Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Mohan, R [UT MD Anderson Cancer Center, Houston, TX (United States); Van Dyk, J [Western University, London, ON (United Kingdom); Fraass, B [Cedars-Sinai Medical Center, Los Angeles, CA (United States); Bortfeld, T [Massachusetts General Hospital, Boston, MA (United States)

    2014-06-15

    Welcome and Introduction - Lawrence N. Rothenberg This symposium is one a continuing series of presentations at AAPM Annual Meetings on the historical aspects of medical physics, radiology, and radiation oncology that have been organized by the AAPM History Committee. Information on previous presentations including “Early Developments in Teletherapy” (Indianapolis 2013), “Historical Aspects of Cross-Sectional Imaging” (Charlotte 2012), “Historical Aspects of Brachytherapy” (Vancouver 2011), “50 Years of Women in Medical Physics” (Houston 2008), and “Roentgen's Early Investigations” (Minneapolis 2007) can be found in the Education Section of the AAPM Website. The Austin 2014 History Symposium will be on “Evolution of Radiation Treatment Planning.” Overview - Radhe Mohan Treatment planning is one of the most critical components in the chain of radiation therapy of cancers. Treatment plans of today contain a wide variety of sophisticated information conveying the potential clinical effectiveness of the designed treatment to practitioners. Examples of such information include dose distributions superimposed on three- or even four-dimensional anatomic images; dose volume histograms, dose, dose-volume and dose-response indices for anatomic structures of interest; etc. These data are used for evaluating treatment plans and for making treatment decisions. The current state-of-the-art has evolved from the 1940s era when the dose to the tumor and normal tissues was estimated approximately by manual means. However, the symposium will cover the history of the field from the late-1950's, when computers were first introduced for treatment planning, to the present state involving the use of high performance computing and advanced multi-dimensional anatomic, functional and biological imaging, focusing only on external beam treatment planning. The symposium will start with a general overview of the treatment planning process including imaging

  19. Group C streptococcal sepsis complicating Fournier gangrene.

    Science.gov (United States)

    Marinella, Mark A

    2005-09-01

    Fournier gangrene is a life-threatening necrotizing fasciitis of the perineal-scrotal area that occurs in diabetic males. Patients typically present with systemic toxicity and significant inflammatory changes in the scrotum and perineum. Most cases of Fournier gangrene are polymicrobic and require urgent surgical debridement and broad-spectrum antibiotic therapy. We describe a case of Fournier gangrene in a young diabetic man that was associated with group C streptococcal bacteremia, an association previously unreported in the literature to our knowledge.

  20. Does Zinc Sulfate Prevent Therapy-Induced Taste Alterations in Head and Neck Cancer Patients? Results of Phase III Double-Blind, Placebo-Controlled Trial from the North Central Cancer Treatment Group (N01C4)

    International Nuclear Information System (INIS)

    Halyard, Michele Y.; Jatoi, Aminah; Sloan, Jeff A.; Bearden, James D.; Vora, Sujay A.; Atherton, Pamela J.; Perez, Edith A.; Soori, Gammi; Zalduendo, Anthony C.; Zhu, Angela; Stella, Philip J.; Loprinzi, Charles L.

    2007-01-01

    Purpose: Taste alterations (dysgeusia) are well described in head and neck cancer patients who undergo radiotherapy (RT). Anecdotal observations and pilot studies have suggested zinc may mitigate these symptoms. This multi-institutional, double-blind, placebo-controlled trial was conducted to provide definitive evidence of this mineral's palliative efficacy. Methods and Materials: A total of 169 evaluable patients were randomly assigned to zinc sulfate 45 mg orally three times daily vs. placebo. Treatment was to be given throughout RT and for 1 month after. All patients were scheduled to receive ≥2,000 cGy of external beam RT to ≥30% of the oral cavity, were able to take oral medication, and had no oral thrush at study entry. Changes in taste were assessed using the previously validated Wickham questionnaire. Results: At baseline, the groups were comparable in age, gender, and planned radiation dose (<6,000 vs. ≥6,000 cGy). Overall, 61 zinc-treated (73%) and 71 placebo-exposed (84%) patients described taste alterations during the first 2 months (p = 0.16). The median interval to taste alterations was 2.3 vs. 1.6 weeks in the zinc-treated and placebo-exposed patients, respectively (p = 0.09). The reported taste alterations included the absence of any taste (16%), bitter taste (8%), salty taste (5%), sour taste (4%), sweet taste (5%), and the presence of a metallic taste (10%), as well as other descriptions provided by a write in response (81%). Zinc sulfate did not favorably affect the interval to taste recovery. Conclusion: Zinc sulfate, as prescribed in this trial, did not prevent taste alterations in cancer patients who were undergoing RT to the oral pharynx

  1. Internet plan and planning

    Directory of Open Access Journals (Sweden)

    Kahriman Emina

    2008-01-01

    Full Text Available Paper discuss specific features of internet plan as well as planning as management process in general in the contemporary environment. No need to stress out that marketing plan and marketing planning is core activity in approaching to market. At the same time, there are a lot specific c request in preparing marketing plan comparing to business planning due to marketing plan is an essential part. The importance of internet plan and planning rely on specific features of the internet network but as a part of general corporate as well as marketing strategy.

  2. Australasian Gastrointestinal Trials Group (AGITG) Contouring Atlas and Planning Guidelines for Intensity-Modulated Radiotherapy in Anal Cancer

    International Nuclear Information System (INIS)

    Ng, Michael; Leong, Trevor; Chander, Sarat; Chu, Julie; Kneebone, Andrew; Carroll, Susan; Wiltshire, Kirsty; Ngan, Samuel; Kachnic, Lisa

    2012-01-01

    Purpose: To develop a high-resolution target volume atlas with intensity-modulated radiotherapy (IMRT) planning guidelines for the conformal treatment of anal cancer. Methods and Materials: A draft contouring atlas and planning guidelines for anal cancer IMRT were prepared at the Australasian Gastrointestinal Trials Group (AGITG) annual meeting in September 2010. An expert panel of radiation oncologists contoured an anal cancer case to generate discussion on recommendations regarding target definition for gross disease, elective nodal volumes, and organs at risk (OARs). Clinical target volume (CTV) and planning target volume (PTV) margins, dose fractionation, and other IMRT-specific issues were also addressed. A steering committee produced the final consensus guidelines. Results: Detailed contouring and planning guidelines and a high-resolution atlas are provided. Gross tumor and elective target volumes are described and pictorially depicted. All elective regions should be routinely contoured for all disease stages, with the possible exception of the inguinal and high pelvic nodes for select, early-stage T1N0. A 20-mm CTV margin for the primary, 10- to 20-mm CTV margin for involved nodes and a 7-mm CTV margin for the elective pelvic nodal groups are recommended, while respecting anatomical boundaries. A 5- to 10-mm PTV margin is suggested. When using a simultaneous integrated boost technique, a dose of 54 Gy in 30 fractions to gross disease and 45 Gy to elective nodes with chemotherapy is appropriate. Guidelines are provided for OAR delineation. Conclusion: These consensus planning guidelines and high-resolution atlas complement the existing Radiation Therapy Oncology Group (RTOG) elective nodal ano-rectal atlas and provide additional anatomic, clinical, and technical instructions to guide radiation oncologists in the planning and delivery of IMRT for anal cancer.

  3. Application of Group-Level Item Response Models in the Evaluation of Consumer Reports about Health Plan Quality

    Science.gov (United States)

    Reise, Steven P.; Meijer, Rob R.; Ainsworth, Andrew T.; Morales, Leo S.; Hays, Ron D.

    2006-01-01

    Group-level parametric and non-parametric item response theory models were applied to the Consumer Assessment of Healthcare Providers and Systems (CAHPS[R]) 2.0 core items in a sample of 35,572 Medicaid recipients nested within 131 health plans. Results indicated that CAHPS responses are dominated by within health plan variation, and only weakly…

  4. Possible reduction of hepatoma formation by Smmu 7721 cells in SCID mice and metastasis formation by B16F10 melanoma cells in C57BL/6 mice by Agaricus blazei murill extract.

    Science.gov (United States)

    Wu, Ming-Fang; Lu, Hsu-Feng; Hsu, Yu-Ming; Tang, Ming-Chu; Chen, Hsueh-Chin; Lee, Ching-Sung; Yang, Yi-Yuan; Yeh, Ming-Yang; Chung, Hsiung-Kwang; Huang, Yi-Ping; Wu, Chih-Chung; Chung, Jing-Gung

    2011-01-01

    Agaricus blazei Murill extract (ABM) has been reported to possess antitumor effects. In this study, the role of ABM in tumor growth and metastasis in vivo was evaluated in experimental Smmu 7721 hepatoma cells in severe combined immunodeficiency (SCID) mice and B16F10 melanoma cells lung metastasis in C57BL/6 mice. For the tumor growth model, the size of the liver tumor mass was about 10 mm to 20 mm in the control group. In comparison with the control group, the tumor mass seem to grow slowly with ABM treatment, especially at the high dose. For the tumor metastasis model, after a six-week treatment, the survival rates of B6 mice were 0%, 30%, 10% and 50% for control group, low, median and high concentration ABM treatment groups, respectively. The survival rate showed that pretreatment of C57BL/6 (B6) mice with ABM lengthened their lifespan after tumor cell inoculation, which supports the notion that ABM successfully reduced lung metastasis formation by B16F10 melanoma cells. The treatment effect was dependent on the concentration of ABM for tumor growth and metastasis in these models.

  5. Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria.

    Science.gov (United States)

    Salzman, Nita H; de Jong, Hendrik; Paterson, Yvonne; Harmsen, Hermie J M; Welling, Gjalt W; Bos, Nicolaas A

    2002-11-01

    Total genomic DNA from samples of intact mouse small intestine, large intestine, caecum and faeces was used as template for PCR amplification of 16S rRNA gene sequences with conserved bacterial primers. Phylogenetic analysis of the amplification products revealed 40 unique 16S rDNA sequences. Of these sequences, 25% (10/40) corresponded to described intestinal organisms of the mouse, including Lactobacillus spp., Helicobacter spp., segmented filamentous bacteria and members of the altered Schaedler flora (ASF360, ASF361, ASF502 and ASF519); 75% (30/40) represented novel sequences. A large number (11/40) of the novel sequences revealed a new operational taxonomic unit (OTU) belonging to the Cytophaga-Flavobacter-Bacteroides phylum, which the authors named 'mouse intestinal bacteria'. 16S rRNA probes were developed for this new OTU. Upon analysis of the novel sequences, eight were found to cluster within the Eubacterium rectale-Clostridium coccoides group and three clustered within the Bacteroides group. One of the novel sequences was distantly related to Verrucomicrobium spinosum and one was distantly related to Bacillus mycoides. Oligonucleotide probes specific for the 16S rRNA of these novel clones were generated. Using a combination of four previously described and four newly designed probes, approximately 80% of bacteria recovered from the murine large intestine and 71% of bacteria recovered from the murine caecum could be identified by fluorescence in situ hybridization (FISH).

  6. Improved evaluations and integral data testing for FENDL. Summary report of the IAEA advisory group meeting held in Garching, Germany, 12 to 16 September 1994

    International Nuclear Information System (INIS)

    Ganesan, S.

    1994-12-01

    The IAEA Nuclear Data Section, in co-operation with several national nuclear data centres and research groups, has created the first version of an internationally available Fusion Evaluated Nuclear Data Library (FENDL-1). The FENDL library has been selected to serve as a comprehensive source of processed and tested nuclear data tailored to the requirements of the Engineering and Development Activities (EDA) of the International Thermonuclear Experimental Reactor (ITER) Project and other fusion-related development projects. Within the scope of the FENDL project, the International Atomic Energy Agency performs the task of coordinating the assembling, processing and testing of a comprehensive, fusion-relevant Fusion Evaluated Nuclear Data Library with unrestricted international distribution. The present report contains the summary of the IAEA Advisory Group Meeting on ''Improved Evaluations and Integral Data Testing for FENDL'', 12-16 September 1994 hosted by the Max-Planck-Institut fuer Plasmaphysik, Garching, Germany. The report presents the current status of the FENDL activity and the future work plans in the form of conclusions and recommendations of the four Working Groups of the Advisory Group Meeting on (1) Basic Evaluations towards FENDL/E-2.0 for ITER Design, (2) Experimental and Calculational Benchmarks on Fusion Neutronics for FENDL Validation, (3) Production and Interfacing of FENDL Libraries to ITER Design, and, (4) Activation. (author)

  7. Plans for managing greater-than-glass C low-level waste

    International Nuclear Information System (INIS)

    Newberry, W.F.; Coleman, J.A.

    1990-01-01

    Low-level waste is defined in the Low-Level Radioactive Waste Policy Amendments Act of 1985 (Title I, Public Law 99-240) as radioactive waste that is neither high-level radioactive waste, spent nuclear fuel, nor by-product material (mill tailings). This paper presents proposed plans for the Department of Energy to fulfill its responsibility to dispose of GTCC LLW under the 1985 law, and to ensure that safe options are available for long-term management of such, pending the availability of disposal capacity. In the absence of a concentration-based definition for high-level waste, there currently is no upper bound for the concentration of radionuclides in low-level waste. DOE's plans for managing and disposing of GTCC LLW are generally consistent with a report issued by the Congressional Office of Technology Assessment in October 1988, An Evaluation of Options for Managing Greater-than-Class C Low-Level Radioactive Waste

  8. Quality assurance program plan for FRG sealed isotopic heat sources project (C-229)

    International Nuclear Information System (INIS)

    Tanke, J.M.

    1997-01-01

    This QAPP implements the Quality Assurance Program Plan for the FRG Sealed Isotopic Heat Sources Project (C-229). The heat source will be relocated from the 324 Building and placed in interim storage at the Central Waste Complex (CWC)

  9. 47 CFR 27.16 - Network access requirements for Block C in the 746-757 and 776-787 MHz bands.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Network access requirements for Block C in the 746-757 and 776-787 MHz bands. 27.16 Section 27.16 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... network restrictions on industry-wide consensus standards, such restrictions would be presumed reasonable...

  10. FY16 Strategic Themes.

    Energy Technology Data Exchange (ETDEWEB)

    Leland, Robert W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-03-01

    I am pleased to present this summary of the Division 1000 Science and Technology Strategic Plan. This plan was created with considerable participation from all levels of management in Division 1000, and is intended to chart our course as we strive to contribute our very best in service of the greater Laboratory strategy. The plan is characterized by four strategic themes: Mission Engagement, Bold Outcomes, Collaborative Environment, and the Safety Imperative. Each theme is accompanied by a brief vision statement, several goals, and planned actions to support those goals throughout FY16. I want to be clear that this is not a strategy to be pursued in tension with the Laboratory strategic plan. Rather, it is intended to describe “how” we intend to show up for the “what” described in Sandia’s Strategic Plan. I welcome your feedback and look forward to our dialogue about these strategic themes. Please join me as we move forward to implement the plan in the coming year.

  11. Risky Group Decision-Making Method for Distribution Grid Planning

    Science.gov (United States)

    Li, Cunbin; Yuan, Jiahang; Qi, Zhiqiang

    2015-12-01

    With rapid speed on electricity using and increasing in renewable energy, more and more research pay attention on distribution grid planning. For the drawbacks of existing research, this paper proposes a new risky group decision-making method for distribution grid planning. Firstly, a mixing index system with qualitative and quantitative indices is built. On the basis of considering the fuzziness of language evaluation, choose cloud model to realize "quantitative to qualitative" transformation and construct interval numbers decision matrices according to the "3En" principle. An m-dimensional interval numbers decision vector is regarded as super cuboids in m-dimensional attributes space, using two-level orthogonal experiment to arrange points uniformly and dispersedly. The numbers of points are assured by testing numbers of two-level orthogonal arrays and these points compose of distribution points set to stand for decision-making project. In order to eliminate the influence of correlation among indices, Mahalanobis distance is used to calculate the distance from each solutions to others which means that dynamic solutions are viewed as the reference. Secondly, due to the decision-maker's attitude can affect the results, this paper defines the prospect value function based on SNR which is from Mahalanobis-Taguchi system and attains the comprehensive prospect value of each program as well as the order. At last, the validity and reliability of this method is illustrated by examples which prove the method is more valuable and superiority than the other.

  12. Spine stereotactic body radiation therapy plans: Achieving dose coverage, conformity, and dose falloff

    International Nuclear Information System (INIS)

    Hong, Linda X.; Shankar, Viswanathan; Shen, Jin; Kuo, Hsiang-Chi; Mynampati, Dinesh; Yaparpalvi, Ravindra; Goddard, Lee; Basavatia, Amar; Fox, Jana; Garg, Madhur; Kalnicki, Shalom; Tomé, Wolfgang A.

    2015-01-01

    We report our experience of establishing planning objectives to achieve dose coverage, conformity, and dose falloff for spine stereotactic body radiation therapy (SBRT) plans. Patients with spine lesions were treated using SBRT in our institution since September 2009. Since September 2011, we established the following planning objectives for our SBRT spine plans in addition to the cord dose constraints: (1) dose coverage—prescription dose (PD) to cover at least 95% planning target volume (PTV) and 90% PD to cover at least 99% PTV; (2) conformity index (CI)—ratio of prescription isodose volume (PIV) to the PTV < 1.2; (3) dose falloff—ratio of 50% PIV to the PTV (R 50% ); (4) and maximum dose in percentage of PD at 2 cm from PTV in any direction (D 2cm ) to follow Radiation Therapy Oncology Group (RTOG) 0915. We have retrospectively reviewed 66 separate spine lesions treated between September 2009 and December 2012 (31 treated before September 2011 [group 1] and 35 treated after [group 2]). The χ 2 test was used to examine the difference in parameters between groups. The PTV V 100% PD ≥ 95% objective was met in 29.0% of group 1 vs 91.4% of group 2 (p < 0.01) plans. The PTV V 90% PD ≥ 99% objective was met in 38.7% of group 1 vs 88.6% of group 2 (p < 0.01) plans. Overall, 4 plans in group 1 had CI > 1.2 vs none in group 2 (p = 0.04). For D 2cm , 48.3% plans yielded a minor violation of the objectives and 16.1% a major violation for group 1, whereas 17.1% exhibited a minor violation and 2.9% a major violation for group 2 (p < 0.01). Spine SBRT plans can be improved on dose coverage, conformity, and dose falloff employing a combination of RTOG spine and lung SBRT protocol planning objectives

  13. Spine stereotactic body radiation therapy plans: Achieving dose coverage, conformity, and dose falloff

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Linda X., E-mail: lhong0812@gmail.com [Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY (United States); Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, NY (United States); Shankar, Viswanathan [Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (United States); Shen, Jin [Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY (United States); Kuo, Hsiang-Chi [Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY (United States); Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, NY (United States); Mynampati, Dinesh [Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY (United States); Yaparpalvi, Ravindra [Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY (United States); Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, NY (United States); Goddard, Lee [Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY (United States); Basavatia, Amar; Fox, Jana; Garg, Madhur; Kalnicki, Shalom; Tomé, Wolfgang A. [Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY (United States); Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, NY (United States)

    2015-10-01

    We report our experience of establishing planning objectives to achieve dose coverage, conformity, and dose falloff for spine stereotactic body radiation therapy (SBRT) plans. Patients with spine lesions were treated using SBRT in our institution since September 2009. Since September 2011, we established the following planning objectives for our SBRT spine plans in addition to the cord dose constraints: (1) dose coverage—prescription dose (PD) to cover at least 95% planning target volume (PTV) and 90% PD to cover at least 99% PTV; (2) conformity index (CI)—ratio of prescription isodose volume (PIV) to the PTV < 1.2; (3) dose falloff—ratio of 50% PIV to the PTV (R{sub 50%}); (4) and maximum dose in percentage of PD at 2 cm from PTV in any direction (D{sub 2cm}) to follow Radiation Therapy Oncology Group (RTOG) 0915. We have retrospectively reviewed 66 separate spine lesions treated between September 2009 and December 2012 (31 treated before September 2011 [group 1] and 35 treated after [group 2]). The χ{sup 2} test was used to examine the difference in parameters between groups. The PTV V{sub 100%} {sub PD} ≥ 95% objective was met in 29.0% of group 1 vs 91.4% of group 2 (p < 0.01) plans. The PTV V{sub 90%} {sub PD} ≥ 99% objective was met in 38.7% of group 1 vs 88.6% of group 2 (p < 0.01) plans. Overall, 4 plans in group 1 had CI > 1.2 vs none in group 2 (p = 0.04). For D{sub 2cm}, 48.3% plans yielded a minor violation of the objectives and 16.1% a major violation for group 1, whereas 17.1% exhibited a minor violation and 2.9% a major violation for group 2 (p < 0.01). Spine SBRT plans can be improved on dose coverage, conformity, and dose falloff employing a combination of RTOG spine and lung SBRT protocol planning objectives.

  14. 76 FR 45248 - PJM Interconnection, L.L.C., PJM Power Providers Group v. PJM Interconnection, L.L.C...

    Science.gov (United States)

    2011-07-28

    ...-002; Docket No. EL11-20-001] PJM Interconnection, L.L.C., PJM Power Providers Group v. PJM Interconnection, L.L.C.; Supplemental Notice of Staff Technical Conference On June 13, 2011, the Commission issued... Resources Services, Inc., Maryland Public Service Commission, Monitoring Analytics, L.L.C., National Rural...

  15. The Structure of the Human Centrin 2-Xeroderma Pigmentosum Group C Protein Complex

    Energy Technology Data Exchange (ETDEWEB)

    Thompson,J.; Ryan, Z.; Salisbury, J.; Kumar, R.

    2006-01-01

    Human centrin-2 plays a key role in centrosome function and stimulates nucleotide excision repair by binding to the xeroderma pigmentosum group C protein. To determine the structure of human centrin-2 and to develop an understanding of molecular interactions between centrin and xeroderma pigmentosum group C protein, we characterized the crystal structure of calcium-loaded full-length centrin-2 complexed with a xeroderma pigmentosum group C peptide. Our structure shows that the carboxyl-terminal domain of centrin-2 binds this peptide and two calcium atoms, whereas the amino-terminal lobe is in a closed conformation positioned distantly by an ordered {alpha}-helical linker. A stretch of the amino-terminal domain unique to centrins appears disordered. Two xeroderma pigmentosum group C peptides both bound to centrin-2 also interact to form an {alpha}-helical coiled-coil. The interface between centrin-2 and each peptide is predominantly nonpolar, and key hydrophobic residues of XPC have been identified that lead us to propose a novel binding motif for centrin.

  16. The Structure of the Human Centrin 2-Xeroderma Pigmentosum Group C Protein Complex

    International Nuclear Information System (INIS)

    Thompson, J.; Ryan, Z.; Salisbury, J.; Kumar, R.

    2006-01-01

    Human centrin-2 plays a key role in centrosome function and stimulates nucleotide excision repair by binding to the xeroderma pigmentosum group C protein. To determine the structure of human centrin-2 and to develop an understanding of molecular interactions between centrin and xeroderma pigmentosum group C protein, we characterized the crystal structure of calcium-loaded full-length centrin-2 complexed with a xeroderma pigmentosum group C peptide. Our structure shows that the carboxyl-terminal domain of centrin-2 binds this peptide and two calcium atoms, whereas the amino-terminal lobe is in a closed conformation positioned distantly by an ordered α-helical linker. A stretch of the amino-terminal domain unique to centrins appears disordered. Two xeroderma pigmentosum group C peptides both bound to centrin-2 also interact to form an α-helical coiled-coil. The interface between centrin-2 and each peptide is predominantly nonpolar, and key hydrophobic residues of XPC have been identified that lead us to propose a novel binding motif for centrin

  17. Heat and Mass Transfer during Solid-Liquid Phase Transition of n-Alkanes in the C{sub 16} to C{sub 19} Range

    Energy Technology Data Exchange (ETDEWEB)

    Holmen, Rune

    2002-07-01

    The main goal of this project has been to study heat and mass transfer during solid-liquid phase transition of n-alkanes in the in the C{sub 16} to C{sub 19} range. Phase transitions of both mixtures and pure components have been investigated. All experiments and simulations have been performed without any convection. Thermal conductivities have been determined at the melting point for solid and liquid unbranched alkanes ranging from C{sub 16} to C{sub 19}. An assessment of the error of the method has been performed. The measurements of solid conductivities are in accordance with measurements reported previously and confirm the applicability of the method. Liquid conductivities are higher than extrapolated values from the literature. The enhanced conductivity is believed to be caused by structural changes close to the melting point which is not taken into account when extrapolating values from the literature. Experiments have been performed for the purpose of investigating the freezing of mixtures of n-alkanes in the C{sub 16}-C{sub 19} range. The positions of the solid-liquid interfaces have been measured as freezing occurred. Calculations of the ratio of liquid and solid conductivities show that the solid structure of mixtures of the investigated n-alkanes is predominantly in a rotator structure at the temperatures investigated. There are indications of a transformation into an orthorhombic structure at lower temperatures. The temperatures on the solid-liquid interface have been measured, and compared with calculated values from chapter 4. The temperature of the interface is represented better by the measured interfacial temperatures than by the calculated interfacial temperatures. The experimental results indicate that the diffusion of heat is the limiting mechanism of phase transition. This result in a homogeneous liquid composition. A numerical model has been developed in order to simulate the experimental freezing of mixtures. The model represents the results

  18. Use of risk assessment panels during revision of the Tongass Land and Resource Management Plan.

    Science.gov (United States)

    Charles G. Shaw

    1999-01-01

    This paper describes the process used to conduct the 16 risk assessment panels and a subsistence working group held during revision of the Tongass land management plan. It provides an overview of how results from the panels were used by forest managers in plan-related decisionmaking, discusses some reactions to the effort, and identifies some opportunities to improve...

  19. Report of the National Technical Planning Group on Uranium Tailings Research

    International Nuclear Information System (INIS)

    Lapp, P.A.

    1981-09-01

    The National Technical Planning Group on Uranium Tailings Research was formed in 1980 to review present activities and plan a research program on the management of wastes after a mine and mill have shut down. At present there are more than 100 million tonnes of uranium tailings on the surface in Canada. Most of these are under management; however, some 8 million tonnes have been abandoned completely. The group concluded that: 1) there has been no systematic attempt to collect and organize the results of measurements already made on tailings; 2) there is an inadequate understanding of the processes that take place in tailings and in the pathways to the biosphere; 3) there is insufficient evidence on the extent of the long-term problem in the closeout of a uranium tailings basin; 4) there is a need to establish standardized measurement methodologies to improve the quality of data taken at different sites across Canada; 5) generic research and development on tailings disposal technology should be within the scope of a national program, whereas site-specific work is the purview of the mines and regulatory agencies; and 6) the uranium producers' contribution to the national tailings program should be their research on site-specific disposal alternatives. The first of these conclusions leads to the proposal to establish a national uranium tailings research program. The second suggests the need for a modelling program, the third and fourth for a national measurement program, and the remaining conclusions refer to disposal technologies research. The conclusions form the basis for a set of recommendations on uranium tailings research

  20. Spectrum of MTHFR gene SNPs C677T and A1298C: a study among 23 population groups of India.

    Science.gov (United States)

    Saraswathy, Kallur Nava; Asghar, Mohammad; Samtani, Ratika; Murry, Benrithung; Mondal, Prakash Ranjan; Ghosh, Pradeep Kumar; Sachdeva, Mohinder Pal

    2012-04-01

    Elevated homocysteine is a risk factor for many complex disorders. The role of methylenetetrahydrofolate reductase (MTHFR) gene in methylation of homocysteine makes it one of the most important candidate genes for these disorders. Considering the heterogeneity in its distribution in world populations, we screened MTHFR C677T and A1298C single nucleotide polymorphisms in a total of 23 Indian caste, tribal and religious population groups from five geographical regions of India and belonging to four major linguistic groups. The frequencies of MTHFR 677T and 1298C alleles were found to be 10.08 and 20.66%, respectively. MTHFR homozygous genotype 677TT was absent in eight population groups and homozygous 1298CC was absent in two population groups. 677T allele was found to be highest among north Indian populations with Indo-European tongue and 1298C was high among Dravidian-speaking tribes of east India and south India. The less common mutant haplotype 677T-1298C was observed among seven population groups and overall the frequency of this haplotype was 0.008, which is similar to that of African populations. cis configuration of 677T and 1298C was 0.94%. However, we could not find any individual with four mutant alleles which supports the earlier observation that presence of more than two mutant alleles may decrease the viability of foetus and possibly be a selective disadvantage in the population.

  1. Effects of neutron irradiation at 4500C and 16 dpa on the properties of various commercial copper alloys

    International Nuclear Information System (INIS)

    Brager, H.R.; Heinisch, H.L.; Garner, F.A.

    1985-01-01

    High-purity copper and eight copper alloys were irradiated to approx.16 dpa at approx.450 0 C in the MOTA experiment in FFTF. These alloys were also examined after aging at 400 0 C for 1000 hours. The radiation-induced changes in the electrical conductivity, tensile properties, and density were measured and compared to those of the aged materials. The changes in conductivity can be either positive or negative depending on the alloy. Changes in tensile properties of most, but not all, of the alloys seem to be primarily dependent on thermal effects rather than the effect of atomic displacements. Radiation at 450 0 C induced changes in density varying from 0.66% densification to 16.6% swelling. The latter occurred in Cu-O.1% Ag and implies a swelling rate of at least 1%/dpa. 6 references, 3 figures, 2 tables

  2. The "1"2C("1"6O,γ"2"8Si) radiative capture reaction at sub-barrier energies

    International Nuclear Information System (INIS)

    Goasduff, A.; Courtin, S.; Haas, F.; Lebhertz, D.; Jenkins, D.G.; Fallis, J.; Ruiz, C.; Hutcheon, D.A.; Amandruz, P.A.; Davis, C.; Hager, U.; Ottewell, D.; Ruprecht, G.

    2014-01-01

    The heavy-ion radiative capture "1"2C("1"6O,γ"2"8Si) was measured at the sub-Coulomb barrier bombarding energy E(lab) = 15.7 MeV, which corresponds to the lowest important resonance observed in the "1"2C + "1"6O fusion excitation function. Thanks to combination of the bismuth germanate (BGO) γ-ray array and the 0 degree DRAGON electromagnetic spectrometer at TRIUMF, the γ-decay spectrum from the entrance channel down to the ground state of "2"8Si was measured. Comparisons of the experimental spectrum to γ spectrum extracted from Monte-Carlo simulations of the complete setup suggest a J"π = 2"+ spin-parity assignment to the entrance channel and yield the radiative capture cross section σ(RC) = 0.22 ± 0.04 μb. Combining this present spin assignment with previous data on radiative capture, a J (J + 1) systematics was constructed, and it indicated a moment of inertia commensurate with the "1"2C+"1"6O grazing angular momentum. Strong dipole transitions are observed from the entrance channel to T = 1 states around 11.5 MeV and are found to result from enhanced M1_I_V transitions to states exhausting a large part of the M1 sum rule built on the ground state of "2"8Si. This specific decay was also reported at bombarding energies close to the Coulomb barrier in our previous study of the "1"2C("1"2C,γ"2"4Mg) heavy-ion radiative capture reaction. Similarities between both systems are investigated. (authors)

  3. Sustainability and Business Planning

    OpenAIRE

    Joy Davidson

    2017-01-01

    This session will consider the longer term sustainability of ROM services and provide an introduction to Business Model Canvas (BMC) as a tool to help develop a longer term business plan. Working in institutional groups, each group will work together to develop a BMC for their institution. This will be revisited at several stages over the life of the project and updated accordingly. By the end of this session, participants will: •be able to flesh out a Business Model C...

  4. Operable Unit 3-13, Group 3, Other Surface Soils Remediation Sets 4-6 (Phase II) Waste Management Plan

    International Nuclear Information System (INIS)

    G. L. Schwendiman

    2006-01-01

    This Waste Management Plan describes waste management and waste minimization activities for Group 3, Other Surface Soils Remediation Sets 4-6 (Phase II) at the Idaho Nuclear Technology and Engineering Center located within the Idaho National Laboratory. The waste management activities described in this plan support the selected response action presented in the Final Record of Decision for Idaho Nuclear Technology and Engineering Center, Operable Unit 3-13. This plan identifies the waste streams that will be generated during implementation of the remedial action and presents plans for waste minimization, waste management strategies, and waste disposition

  5. Compact quantum group C*-algebras as Hopf algebras with approximate unit

    International Nuclear Information System (INIS)

    Do Ngoc Diep; Phung Ho Hai; Kuku, A.O.

    1999-04-01

    In this paper, we construct and study the representation theory of a Hopf C*-algebra with approximate unit, which constitutes quantum analogue of a compact group C*-algebra. The construction is done by first introducing a convolution-product on an arbitrary Hopf algebra H with integral, and then constructing the L 2 and C*-envelopes of H (with the new convolution-product) when H is a compact Hopf *-algebra. (author)

  6. Rv2131c gene product: An unconventional enzyme that is both inositol monophosphatase and fructose-1,6-bisphosphatase

    International Nuclear Information System (INIS)

    Gu Xiaoling; Chen Mao; Shen Hongbo; Jiang Xin; Huang Yishu; Wang Honghai

    2006-01-01

    Inositol monophosphatase is an enzyme in the biosynthesis of myo-inostiol, a crucial substrate for the synthesis of phosphatidylinositol, which has been demonstrated to be an essential component of mycobacteria. In this study, the Rv2131c gene from Mycobacterium tuberculosis H37Rv was cloned into the pET28a vector and the recombinant plasmid was transformed into Escherichia coli BL21 (DE3) strain, allowing the expression of the enzyme in fusion with a histidine-rich peptide on the N-terminal. The fusion protein was purified from the soluble fraction of the lysed cells under native conditions by immobilized metal affinity chromatography (IMAC). The purified Rv2131c gene product showed inositol monophosphatase activity but with substrate specificity that was broader than those of several bacterial and eukaryotic inositol monophosphatases, and it also acted as fructose-1,6-bisphosphatase. The dimeric enzyme exhibited dual activities of IMPase and FBPase, with K m of 0.22 ± 0.03 mM for inositol-1-phosphate and K m of 0.45 ± 0.05 mM for fructose-1,6-bisphosphatase. To better understand the relationship between the function and structure of the Rv2131c enzyme, we constructed D40N, L71A, and D94N mutants and purified these corresponding proteins. Mutations of D40N and D94N caused the proteins to almost completely lose both the inositol monophosphatase and fructose-1,6-bisphosphatase activities. However, L71A mutant did not cause loss either of the activities, but the activity toward the inositol was 12-fold more resistant to inhibition by lithium (IC 5 ∼ 60 mM). Based on the substrate specificity and presence of conserved sequence motifs of the M. tuberculosis Rv2131c, we proposed that the enzyme belonged to class IV fructose-1,6-bisphosphatase (FBPase IV)

  7. Poststreptococcal keratouveitis associated with group C streptococcus pharyngitis

    Directory of Open Access Journals (Sweden)

    Nataneli N

    2011-09-01

    Full Text Available Nathaniel Nataneli1, Zenia P Aguilera1, Pearl S Rosenbaum1, Tamar Goldstein1,2, Martin Mayers11Department of Ophthalmology, Bronx-Lebanon Hospital Center, Albert Einstein College of Medicine, Bronx, NY, USA; 2Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelPurpose: To report the first case of poststreptococcal syndrome uveitis (PSU in association with group C streptococcus (GCS.Patients and methods: Chart review of a 24-year-old man who presented with bilateral ocular redness, pain, and photophobia for 5 days and "white rings" around his eyes for a duration of 3 days. The patient further reported fever and sore throat in the preceding week. Slit-lamp examination showed bilateral keratouveitis. A thorough uveitis workup, antistreptolysin O (ASLO titer, and throat culture were obtained. The patient was treated with frequent topical steroids and systemic doxycycline. The uveitis and keratitis subsided over the next few weeks, leaving extensive peripheral keratolysis.Results: The results of laboratory diagnostic testing revealed an elevated ASLO, C-reactive protein, as well as HLA-B27 positivity. Throat cultures grew beta-hemolytic GCS; group A streptococcus was culture negative.Conclusion: GCS pharyngitis may be a causative organism of PSU.Keywords: pharyngitis, keratolysis, keratouveitis

  8. Implementation intention and planning interventions in Health Psychology : Recommendations from the Synergy Expert Group for research and practice

    NARCIS (Netherlands)

    Hagger, M.S.; Luszczynska, A.; de Wit, J.; Benyamini, Y.; Burkert, S.; Chamberland, P.-E.; Chater, A.; Dombrowski, S.U.; van Dongen, A.; French, D.P.; Gauchet, A.; Hankonen, N.; Karekla, M.; Kinney, A.Y.; Kwasnicka, D.; Lo, S.H.; López-Roig, S.; Meslot, C.; Marques, M.M.; Neter, E.; Plass, A.M.; Potthoff, S.; Rennie, L.; Scholz, U.; Stadler, G.; Stolte, E.; ten Hoor, G.; Verhoeven, A.A.C.; Wagner, M.; Oettingen, G.; Sheeran, P.; Gollwitzer, P.M.

    2016-01-01

    The current article details a position statement and recommendations for future research and practice on planning and implementation intentions in health contexts endorsed by the Synergy Expert Group. The group comprised world-leading researchers in health and social psychology and behavioural

  9. Implementation intention and planning interventions in Health Psychology: Recommendations from the Synergy Expert Group for research and practice

    NARCIS (Netherlands)

    Hagger, M.S.; Luszczynska, A.; de Wit, J.; Benyamini, Y.; Burkert, S.; Chamberland, P.E.; Chater, A.; Dombrowski, S.U.; van Dongen, A.; French, D.P.; Gauchet, A.; Hankonen, N.; Karekla, M.; Kinney, A.Y.; Kwasnicka, D.; Lo, S.H.; López-Roig, S.; Meslot, C.; Marques, M.M.; Neter, E.; Plass, A.M.; Potthoff, S.; Rennie, L.; Scholz, U; Stadler, G.; Stolte, E.; Ten Hoor, G.; Verhoeven, A.; Wagner, M.; Oettingen, G.; Sheeran, P.; Gollwitzer, P.M.

    2016-01-01

    The current article details a position statement and recommendations for future research and practice on planning and implementation intentions in health contexts endorsed by the Synergy Expert Group. The group comprised world-leading researchers in health and social psychology and behavioural

  10. Selecting a Risk-Based SQC Procedure for a HbA1c Total QC Plan.

    Science.gov (United States)

    Westgard, Sten A; Bayat, Hassan; Westgard, James O

    2017-09-01

    Recent US practice guidelines and laboratory regulations for quality control (QC) emphasize the development of QC plans and the application of risk management principles. The US Clinical Laboratory Improvement Amendments (CLIA) now includes an option to comply with QC regulations by developing an individualized QC plan (IQCP) based on a risk assessment of the total testing process. The Clinical and Laboratory Standards Institute (CLSI) has provided new practice guidelines for application of risk management to QC plans and statistical QC (SQC). We describe an alternative approach for developing a total QC plan (TQCP) that includes a risk-based SQC procedure. CLIA compliance is maintained by analyzing at least 2 levels of controls per day. A Sigma-Metric SQC Run Size nomogram provides a graphical tool to simplify the selection of risk-based SQC procedures. Current HbA1c method performance, as demonstrated by published method validation studies, is estimated to be 4-Sigma quality at best. Optimal SQC strategies require more QC than the CLIA minimum requirement of 2 levels per day. More complex control algorithms, more control measurements, and a bracketed mode of operation are needed to assure the intended quality of results. A total QC plan with a risk-based SQC procedure provides a simpler alternative to an individualized QC plan. A Sigma-Metric SQC Run Size nomogram provides a practical tool for selecting appropriate control rules, numbers of control measurements, and run size (or frequency of SQC). Applications demonstrate the need for continued improvement of analytical performance of HbA1c laboratory methods.

  11. Preferential repair of nuclear matrix associated DNA in xeroderma pigmentosum complementation group C

    International Nuclear Information System (INIS)

    Mullenders, L.H.F.; Kesteren, A.C. van; Bussmann, C.J.M.; Zeeland, A.A. van; Natarajan, A.T.

    1984-01-01

    The distribution of ultraviolet-induced DNA repair patches in the genome of xeroderma pigmentosum cells of complementation group C was investigated by determining the molecular weight distribution of repair labeled DNA and prelabeled DNA in alkaline sucrose gradients after treatment with the dimer-specific endonuclease V of bacteriophage T 4 . The results suggest that DNA-repair synthesis in xeroderma pigmentosum cells of complementation group C occurs in localized regions of the genome. Analysis of the spatial distribution of ultraviolet-induced repair patches in DNA loops attached to the nuclear matrix revealed that in xeroderma pigmentosum cells of complementation group C repair patches are preferentially situated near the attachment sites of DNA loops at the nuclear matrix. In normal human fibroblasts the authors observed no enrichment of repair-labeled DNA at the nuclear matrix and repair patches appeared to be distributed randomly along the DNA loops. The enrichment of repair-labeled DNA at the nuclear matrix in xeroderma pigmentosum cells of complementation group C may indicate that the residual DNA-repair synthesis in these cells occurs preferentially in regions of the genome. (Auth.)

  12. Treament Response in the neck: p16+ versus p16- oropharyngeal cancer

    International Nuclear Information System (INIS)

    Mak, Daisy; Hicks, Rodney J.; Rischin, Danny; Solomon, Ben; Peters, Lester; Corry, June; Bressel, Mathias; Young, Richard J.

    2013-01-01

    To compare nodal response rates following chemoradiotherapy in patients with p16+ and p16− oropharyngeal squamous cell carcinoma (OPSCC). Patients with node-positive OPSCC treated at Peter MacCallum Cancer Centre on the published phase I–III tirapazamine trials were identified. All patients had conventional assessment (clinical examination (CA), CT and/or MRI) and positron emission tomography (PET) at both baseline and 2–4 months post-treatment. There were 30 p16+ and 18 p16− patients, the former group having significantly higher stage nodal disease (P=0.016). The mean overall reduction in nodal size at post-treatment assessment was similar in p16+ and p16− patients (78% vs. 75%), and no statistically significant difference in nodal complete response (CR) rates was detected by either CA (50% vs. 39%, P=0.35) or PET/PET-CT (93% vs. 83%, P=0.19). PET was significantly more accurate in determining the true nodal CR rate in both groups, with a negative predictive value of 96%. Nodal response rates following chemoradiotherapy appear to be similar in p16+ and p16− patients when assessed by either CA or PET/PET-CT. However, higher nodal CR was seen in PET/PET-CT compared with CA in both groups. Metabolic imaging is more accurate than CA in assessing nodal response post-treatment.

  13. Trial of a "credit card" asthma self-management plan in a high-risk group of patients with asthma.

    Science.gov (United States)

    D'Souza, W; Burgess, C; Ayson, M; Crane, J; Pearce, N; Beasley, R

    1996-05-01

    The "credit card" asthma self-management plan provides the adult asthmatic patient with simple guidelines for the self-management of asthma, which are based on the self-assessment of peak expiratory flow rate recordings and symptoms. The study was a trial of the clinical efficacy of the credit card plan in a high-risk group of asthmatic patients. In this "before-and-after" trial, patients discharged from the emergency department of Wellington Hospital, after treatment for severe asthma were invited to attend a series of hospital outpatient clinics at which the credit card plan was introduced. Questionnaires were used to compare markers of asthma morbidity, requirement for emergency medical care, and medication use during the 6-month period before and after intervention with the credit card plan. Of the 30 patients with asthma who attended the first outpatient clinic, 26 (17 women and 9 men) completed the program. In these 26 participants, there was a reduction in both morbidity and requirement for acute medical services: specifically, the proportion waking with asthma more than once a week decreased from 65% to 23% (p = 0.005) and the proportion visiting the emergency department for treatment of severe asthma decreased from 58% to 15% (p = 0.004). The patients attending the clinics commented favorably on the plan, in particular on its usefulness as an educational tool for monitoring and treating their asthma. Although the interpretation of this study is limited by the lack of a randomized control group, the findings are consistent with other evidence that the credit card asthma self-management plan can be an effective and acceptable system for improving asthma care in a high-risk group of adult patients with asthma.

  14. MicroRNA-200c modulates the expression of MUC4 and MUC16 by directly targeting their coding sequences in human pancreatic cancer.

    Directory of Open Access Journals (Sweden)

    Prakash Radhakrishnan

    Full Text Available Transmembrane mucins, MUC4 and MUC16 are associated with tumor progression and metastatic potential in human pancreatic adenocarcinoma. We discovered that miR-200c interacts with specific sequences within the coding sequence of MUC4 and MUC16 mRNAs, and evaluated the regulatory nature of this association. Pancreatic cancer cell lines S2.028 and T3M-4 transfected with miR-200c showed a 4.18 and 8.50 fold down regulation of MUC4 mRNA, and 4.68 and 4.82 fold down regulation of MUC16 mRNA compared to mock-transfected cells, respectively. A significant reduction of glycoprotein expression was also observed. These results indicate that miR-200c overexpression regulates MUC4 and MUC16 mucins in pancreatic cancer cells by directly targeting the mRNA coding sequence of each, resulting in reduced levels of MUC4 and MUC16 mRNA and protein. These data suggest that, in addition to regulating proteins that modulate EMT, miR-200c influences expression of cell surface mucins in pancreatic cancer.

  15. Evaluating the impact of a disease management program for chronic complex conditions at two large northeast health plans using a control group methodology.

    Science.gov (United States)

    Schwerner, Henry; Mellody, Timothy; Goldstein, Allan B; Wansink, Daryl; Sullivan, Virginia; Yelenik, Stephan N; Charlton, Warwick; Lloyd, Kelley; Courtemanche, Ted

    2006-02-01

    The objective of this study was to observe trends in payer expenditures for plan members with one of 14 chronic, complex conditions comparing one group with a disease management program specific to their condition (the intervention group) and the other with no specific disease management program (the control group) for these conditions. The authors used payer claims and membership data to identify members eligible for the program in a 12-month baseline year (October 2001 to September 2002) and a subsequent 12-month program year (October 2002 to September 2003). Two payers were analyzed: one health plan with members primarily in New Jersey (AmeriHealth New Jersey [AHNJ]), where the disease management program was offered, and one affiliated large plan with members primarily in the metro Philadelphia area, where the program was not offered. The claims payment policy for both plans is identical. Intervention and control groups were analyzed for equivalence. The analysis was conducted in both groups over identical time periods. The intervention group showed statistically significant (p control group. Intervention group members showed a reduction in expenditures of -8%, while control group members showed an increase of +10% over identical time periods. Subsequent analyses controlling for outliers and product lines served to confirm the overall results. The disease management program is likely responsible for the observed difference between the intervention and control group results. A well-designed, targeted disease management program offered by a motivated, supportive health plan can play an important role in cost improvement strategies for members with complex, chronic conditions.

  16. Readiness review plan for the in situ vitrification demonstration of Seepage Pit 1 in Waste Area Grouping 7

    International Nuclear Information System (INIS)

    1995-05-01

    A treatability study is planned that encompasses the application of in situ vitrification (ISV) to at least two segments of the Oak Ridge National Laboratory Seepage Pit I during the third quarter of fiscal year 1995. Before the treatability study can be initiated, the proposed activity must be subjected to an Operational Readiness Review (ORR). ORR is a structured methodology of determining readiness to proceed as outlined in Martin Marietta Energy Systems, Inc. (Energy Systems), Environmental Restoration Waste Management Procedure ER/C-P1610, which provides Energy Systems organizations assurance that the work to be performed is consistent with management's expectations and that the subject activity is ready to proceed safely. The readiness review plan provides details of the review plan overview and the scope of work to be performed. The plan also identifies individuals and position responsibilities for implementing the activity. The management appointed Readiness Review Board (RRB) has been identified. A Field Readiness Review Team (FRT), a management appointed multidisciplinary group, has been established (1) to evaluate the ISV treatability study, (2) to identify and assemble supporting objective evidences of the readiness to proceed, and (3) to assist the team leader in presenting the evidences to the RRB. A major component of RRB is the formulation of readiness review criteria months before the operation. A comprehensive readiness review tree (a positive logic tree) is included, which identifies the activities required for the development of the readiness criteria. The readiness review tree serves as a tool to prevent the omission of an item that could affect system performance. All deficiencies identified in the review will be determined as prestart findings and must be resolved before the project is permitted to proceed. The final approval of the readiness to proceed will be the decision of RRB

  17. Surveillance Plan for environmental monitoring in Waste Area Grouping 6 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    International Nuclear Information System (INIS)

    1993-12-01

    This Surveillance Plan has been developed as part of the Environmental Monitoring Plan for Waste Area Grouping 6 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Environmental monitoring will be conducted in two phases: the baseline monitoring phase and the routine annual monitoring phase. The baseline monitoring phase will be conducted to establish the baseline contaminant release conditions at the Waste Area Grouping (WAG), to confirm the site-related chemicals of concern (COC), and to gather data to confirm the site hydrologic model The baseline monitoring phase is expected to begin in 1994 and continue for 12--18 months. The routine annual monitoring phase will consist of continued sampling and analyses of COC to determine off-WAG contaminant flux, to identify trends in releases, and to confirm the COC The routine annual monitoring phase will continue for ∼4 years after completion of the baseline monitoring phase. This Surveillance Plan presents the technical and quality assurance surveillance activities for the various WAG 6 environmental monitoring and data evaluation plans and implementing procedures

  18. Patients Lacking a KIR-Ligand of HLA Group C1 or C2 Have a Better Outcome after Umbilical Cord Blood Transplantation

    Directory of Open Access Journals (Sweden)

    Carmen Martínez-Losada

    2017-07-01

    Full Text Available Donor natural killer (NK cells can destroy residual leukemic cells after allogeneic hematopoietic stem cell transplantation. This effect is based on the interaction of killer-cell immunoglobulin-like receptors (KIR of donor NK cells with ligands of the major histocompatibility complex found on the surface of the target cells. HLA-C1 subtypes provide the ligand for KIR2DL2 and KIR2DL3 and the HLA-C2 subtypes for KIR2DL1. We have studied the probability of relapse (PR after single-unit unrelated cord blood transplantation (UCBT in relation to the potential graft-vs.-leukemia effect mediated by NK cells present in the umbilical cord blood (UCB by analyzing KIR-ligand and HLA-C typing of the receptor. Data from 33 consecutive patients given a single unit UCBT were included. We have considered two groups of patients based on the absence or the presence of one of the C-ligands for inhibitory KIR and the incompatibility HLA-C1/2 between UCB and patients. Group 1 (n = 21: the patient lacks a C-ligand for inhibitory KIR present in UCB NK cells, i.e., patients homozygous C1/C1 or C2/C2. Group 2 (n = 12: patients heterozygous C1/C2 in which KIR-mediated graft-vs.-leukemia effect is not expected (presence of both C ligands for inhibitory KIR in the receptor. With a median follow-up post-UCBT of 93 months, patients with absence of a C-ligand for inhibitory KIRs (Group 1 showed a lower actuarial PR than patients with both C-ligands (group 2: 21 ± 10 vs. 68 ± 18% at 2 year and 36 ± 13 vs. 84 ± 14% at 5 years (p = 0.025, respectively. In patients with acute lymphoblastic leukemia, the 2-year PR was 36 ± 21% for group 1 and 66 ± 26% for 2 (p = 0.038. Furthermore, group 1 had a lower incidence of grades II–IV acute graft-vs.-host disease (p = 0.04. In the setting of UCBT, the absence of a C-ligand (C1 or C2 of inhibitory KIR in the patient is associated with lower PR, which is probably due to the graft

  19. Neutral strange particle production in π-p interactions at 16 GeV/c

    International Nuclear Information System (INIS)

    Balea, E.; Berceanu, S.; Coca, C.; Sararu, A.; Karnaukhov, M.V.; Moroz, I.V.; Kellner, G.; Mihul, A.

    1979-06-01

    The production of Ksub(s)sup(0), Λ and anti Λ in π - p interactions at 16 GeV/c is investigated. Cross sections for single strange particle are determined, both inclusively and as functions of the charged multiplicity. Some characteristics of the multiplicity distributions are also discussed. Inclusive distributions are studied as function of longitudinal and transverse variables of Vsup(0) and missing mass squared. The average charged multiplicities of the systems recoiling against the Λ and Ksub(s)sup(0) are presented. (author)

  20. Surface water sampling and analysis plan for environmental monitoring in Waste Area Grouping 6 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    This Sampling and Analysis Plan addresses surface water monitoring, sampling, and analysis activities that will be conducted in support of the Environmental Monitoring Plan for Waste Area Grouping (WAG) 6. WAG 6 is a shallow-burial land disposal facility for low-level radioactive waste at the Oak Ridge National Laboratory, a research facility owned by the US Department of Energy and managed by Martin Marietta Energy Systems, Inc. Surface water monitoring will be conducted at nine sites within WAG 6. Activities to be conducted will include the installation, inspection, and maintenance of automatic flow-monitoring and sampling equipment and manual collection of various water and sediment samples. The samples will be analyzed for various organic, inorganic, and radiological parameters. The information derived from the surface water monitoring, sampling, and analysis will aid in evaluating risk associated with contaminants migrating off-WAG, and will be used in calculations to establish relationships between contaminant concentration (C) and flow (Q). The C-Q relationship will be used in calculating the cumulative risk associated with the off-WAG migration of contaminants.

  1. Surface water sampling and analysis plan for environmental monitoring in Waste Area Grouping 6 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Environmental Restoration Program

    International Nuclear Information System (INIS)

    1994-06-01

    This Sampling and Analysis Plan addresses surface water monitoring, sampling, and analysis activities that will be conducted in support of the Environmental Monitoring Plan for Waste Area Grouping (WAG) 6. WAG 6 is a shallow-burial land disposal facility for low-level radioactive waste at the Oak Ridge National Laboratory, a research facility owned by the US Department of Energy and managed by Martin Marietta Energy Systems, Inc. Surface water monitoring will be conducted at nine sites within WAG 6. Activities to be conducted will include the installation, inspection, and maintenance of automatic flow-monitoring and sampling equipment and manual collection of various water and sediment samples. The samples will be analyzed for various organic, inorganic, and radiological parameters. The information derived from the surface water monitoring, sampling, and analysis will aid in evaluating risk associated with contaminants migrating off-WAG, and will be used in calculations to establish relationships between contaminant concentration (C) and flow (Q). The C-Q relationship will be used in calculating the cumulative risk associated with the off-WAG migration of contaminants

  2. GALAXY INTERACTIONS IN COMPACT GROUPS. I. THE GALACTIC WINDS OF HCG16

    Energy Technology Data Exchange (ETDEWEB)

    Vogt, Frederic P. A.; Dopita, Michael A.; Kewley, Lisa J., E-mail: fvogt@mso.anu.edu.au [Mount Stromlo Observatory, Research School of Astronomy and Astrophysics, Australian National University, Cotter Road, Weston Creek, ACT 2611 (Australia)

    2013-05-10

    Using the WiFeS integral field spectrograph, we have undertaken a series of observations of star-forming galaxies in compact groups. In this first paper dedicated to the project, we present the analysis of the spiral galaxy NGC 838, a member of the Hickson Compact Group 16, and of its galactic wind. Our observations reveal that the wind forms an asymmetric, bipolar, rotating structure, powered by a nuclear starburst. Emission line ratio diagnostics indicate that photoionization is the dominant excitation mechanism at the base of the wind. Mixing from slow shocks (up to 20%) increases further out along the outflow axis. The asymmetry of the wind is most likely caused by one of the two lobes of the wind bubble bursting out of its H I envelope, as indicated by line ratios and radial velocity maps. The characteristics of this galactic wind suggest that it is caught early (a few Myr) in the wind evolution sequence. The wind is also quite different from the galactic wind in the partner galaxy NGC 839 which contains a symmetric, shock-excited wind. Assuming that both galaxies have similar interaction histories, the two different winds must be a consequence of the intrinsic properties of NGC 838 and NGC 839 and their starbursts.

  3. Portable exhausters POR-004 SKID B, POR-005 SKID C, POR-006 SKID D storage plan

    International Nuclear Information System (INIS)

    Nelson, O.D.; Keller, G.M.

    1997-01-01

    This document provides a storage plan for portable exhausters POR-004 SKID B, POR-005 SKID C, AND POR-006 SKID D. The exhausters will be stored until they are needed by the TWRS (Tank Waste Remediation Systems) Saltwell Pumping Program. The storage plan provides criteria for portable exhauster storage, periodic inspections during storage, and retrieval from storage

  4. Critical role of the 12C(αγ) 16O reaction is stellar evolution and synthesis

    International Nuclear Information System (INIS)

    Weaver, T.A.

    1993-01-01

    The extreme sensitivity of stellar evolution and nucleosynthesis to the rate of the 12 C(α,γ) 16 O reaction will be reviewed in the context of models of the complete evolution of 12 to 40 solar mass stars from their birth on the main-sequence to their death in supernova explosions. The nucleosynthesis resulting from integrating the yields of these models over plausible initial stellar mass distributions is found to be in excellent agreement with the observed solar abundances of virtually all intermediate mass isotopes if, and only if, the 12 C(α,γ) 16 O Tate falls within a narrow subset of its currently experimentally allowed range. Factor of 2 to 3 variations in this rate lead to up to a factor of 100 variations in major isotopic production ratios. The importance of further experiments to accurately measure this rate (which is apparently dominated by the contributions of subthreshold resonances) will be stressed

  5. The radioactive waste management program of the C.E.C. Achievements, planning and perspectives

    International Nuclear Information System (INIS)

    Girardi, F.; Orlowski, S.

    1986-01-01

    The achievements of twelve years of waste management research, carried out by shared-cost actions with laboratories of member countries of the European Communities and by direct research at its Joint Research Center are being reviewed. Activities were essentially directed to reach three goals: (a) to develop the necessary waste treatment and conditioning technologies, (b) to study disposal concepts in various types of geological formations in the European Community, (c) to address problems connected with their implementation such as safety assessment, quality assurance, financing, etc., which are particularly suited to the Community framework. Planning and perspectives for the next decade are also given. Implementation and optimization of concepts presently under development is indicated as the prevailing objective

  6. Structure of 10Be and 16C nuclei via break-up reactions studied with the 4π Chimera array

    Science.gov (United States)

    Dell'Aquila, D.; Acosta, L.; Amorini, F.; Andolina, R.; Auditore, L.; Berceanu, I.; Cardella, G.; Chatterjiee, M. B.; De Filippo, E.; Francalanza, L.; Gnoffo, B.; Grzeszczuk, A.; Lanzalone, G.; Lombardo, I.; Martorana, N.; Minniti, T.; Pagano, A.; Pagano, E. V.; Papa, M.; Pirrone, S.; Politi, G.; Pop, A.; Porto, F.; Quattrocchi, L.; Rizzo, F.; Rosato, E.; Russotto, P.; Trifirò, A.; Trimarchi, M.; Verde, G.; Vigilante, M.

    2018-01-01

    The study of cluster states in neutron-rich Be and C isotopes is a subject of interest in Nuclear Physics. These states should be characterized by high deformation where α-clusters are bounded by valence neutrons. We performed a spectroscopic study of 10Be and 16C isotopes via projectile break-up reactions, by using radioactive beams produced at the INFN-LNS FRIBs facility and the Chimera 4π array. The possible evidence of a new 10Be state at 13.5 MeV excitation energy was found in the 6He+4He disintegration channel. The spectroscopy of 16C was studied via the 6He+10Be break-up channel; in this case we found the indication of a possible new state at about 20.6 MeV.

  7. Up-regulation of tumor suppressor genes by exogenous dhC16-Cer contributes to its anti-cancer activity in primary effusion lymphoma.

    Science.gov (United States)

    Cao, Yueyu; Qiao, Jing; Lin, Zhen; Zabaleta, Jovanny; Dai, Lu; Qin, Zhiqiang

    2017-02-28

    Primary effusion lymphoma (PEL) is a rare and highly aggressive B-cell malignancy with Kaposi's sarcoma-associated herpesvirus (KSHV) infection, while lack of effective therapies. Our recent data indicated that targeting the sphingolipid metabolism by either sphingosine kinase inhibitor or exogenous ceramide species induces PEL cell apoptosis and suppresses tumor progression in vivo. However, the underlying mechanisms for these exogenous ceramides "killing" PEL cells remain largely unknown. Based on the microarray analysis, we found that exogenous dhC16-Cer treatment affected the expression of many cellular genes with important functions within PEL cells such as regulation of cell cycle, cell survival/proliferation, and apoptosis/anti-apoptosis. Interestingly, we found that a subset of tumor suppressor genes (TSGs) was up-regulated from dhC16-Cer treated PEL cells. One of these elevated TSGs, Thrombospondin-1 (THBS1) was required for dhC16-Cer induced PEL cell cycle arrest. Moreover, dhC16-Cer up-regulation of THBS1 was through the suppression of multiple KSHV microRNAs expression. Our data demonstrate that exogenous ceramides display anti-cancer activities for PEL through regulation of both host and oncogenic virus factors.

  8. cRGD-installed docetaxel-loaded mertansine prodrug micelles: redox-triggered ratiometric dual drug release and targeted synergistic treatment of B16F10 melanoma

    Science.gov (United States)

    Zhong, Ping; Qiu, Min; Zhang, Jian; Sun, Huanli; Cheng, Ru; Deng, Chao; Meng, Fenghua; Zhong, Zhiyuan

    2017-07-01

    Combinatorial chemotherapy, which has emerged as a promising treatment modality for intractable cancers, is challenged by a lack of tumor-targeting, robust and ratiometric dual drug release systems. Here, docetaxel-loaded cRGD peptide-decorated redox-activable micellar mertansine prodrug (DTX-cRGD-MMP) was developed for targeted and synergistic treatment of B16F10 melanoma-bearing C57BL/6 mice. DTX-cRGD-MMP exhibited a small size of ca. 49 nm, high DTX and DM1 loading, low drug leakage under physiological conditions, with rapid release of both DTX and DM1 under a cytoplasmic reductive environment. Notably, MTT and flow cytometry assays showed that DTX-cRGD-MMP brought about a synergistic antitumor effect to B16F10 cancer cells, with a combination index of 0.37 and an IC50 over 3- and 13-fold lower than cRGD-MMP (w/o DTX) and DTX-cRGD-Ms (w/o DM1) controls, respectively. In vivo studies revealed that DTX-cRGD-MMP had a long circulation time and a markedly improved accumulation in the B16F10 tumor compared with the non-targeting DTX-MMP control (9.15 versus 3.13% ID/g at 12 h post-injection). Interestingly, mice treated with DTX-cRGD-MMP showed almost complete growth inhibition of B16F10 melanoma, with tumor inhibition efficacy following an order of DTX-cRGD-MMP > DTX-MMP (w/o cRGD) > cRGD-MMP (w/o DTX) > DTX-cRGD-Ms (w/o DM1) > free DTX. Consequently, DTX-cRGD-MMP significantly improved the survival rates of B16F10 melanoma-bearing mice. Importantly, DTX-cRGD-MMP caused little adverse effects as revealed by mice body weights and histological analyses. The combination of two mitotic inhibitors, DTX and DM1, appears to be an interesting approach for effective cancer therapy.

  9. Health and Safety Plan for Waste Area Grouping 6 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    International Nuclear Information System (INIS)

    Van Hoesen, S.D.; Clark, C. Jr.; Burman, S.N.; Manis, L.W.; Barre, W.L.

    1993-12-01

    The Martin Marietta Energy Systems, Inc. (Energy Systems), policy is to provide a safe and healthful workplace for all employees and subcontractors. The accomplishment of this policy requires that operations at Waste Area Grouping (WAG) 6 at the Department of Energy (DOE) Oak Ridge National Laboratory are guided by an overall plan and consistent proactive approach to safety and health (S ampersand H) issues. The plan is written to utilize past experience and best management practices to minimize hazards to human health or the environment from events such as fires, explosions, falls, mechanical hazards, or any unplanned release of hazardous or radioactive materials to air, soil, or surface water This plan explains additional site-specific health and safety requirements such as Site Specific Hazards Evaluation Addendums (SSHEAs) to the Site Safety and Health Plan which should be used in concert with this plan and existing established procedures

  10. Managing Greater-Than-Class C low-level radioactive waste: A strategic plan

    International Nuclear Information System (INIS)

    1990-04-01

    This strategic plan describes the DOE goals, objectives, and strategy for fulfilling its responsibility to dispose of Greater-Than-Class C low-level radioactive waste (GTCC LLW), in accordance with the requirements of Section 3(b) of the Low-Level Radioactive Waste Policy Amendments Act of 1985, Public Law 99-240. The strategy for fulfilling this responsibility consists of three sequential tasks: interim storage of limited quantities of GTCC LLW at currently operating DOE facilities on an as-needed basis; general acceptance of GTCC LLW for storage in a DOE dedicated facility pending disposal; and disposal in a facility licensed by the Nuclear Regulatory Commission (NRC). The objectives, assumptions, and strategies for each of these tasks are presented in this plan

  11. Identification of a novel acetate-utilizing bacterium belonging to Synergistes group 4 in anaerobic digester sludge.

    Science.gov (United States)

    Ito, Tsukasa; Yoshiguchi, Kazumi; Ariesyady, Herto Dwi; Okabe, Satoshi

    2011-12-01

    Major acetate-utilizing bacterial and archaeal populations in methanogenic anaerobic digester sludge were identified and quantified by radioisotope- and stable-isotope-based functional analyses, microautoradiography-fluorescence in situ hybridization (MAR-FISH) and stable-isotope probing of 16S rRNA (RNA-SIP) that can directly link 16S rRNA phylogeny with in situ metabolic function. First, MAR-FISH with (14)C-acetate indicated the significant utilization of acetate by only two major groups, unidentified bacterial cells and Methanosaeta-like filamentous archaeal cells, in the digester sludge. To identify the acetate-utilizing unidentified bacteria, RNA-SIP was conducted with (13)C(6)-glucose and (13)C(3)-propionate as sole carbon source, which were followed by phylogenetic analysis of 16S rRNA. We found that bacteria belonging to Synergistes group 4 were commonly detected in both 16S rRNA clone libraries derived from the sludge incubated with (13)C-glucose and (13)C-propionate. To confirm that this bacterial group can utilize acetate, specific FISH probe targeting for Synergistes group 4 was newly designed and applied to the sludge incubated with (14)C-acetate for MAR-FISH. The MAR-FISH result showed that bacteria belonging to Synergistes group 4 significantly took up acetate and their active population size was comparable to that of Methanosaeta in this sludge. In addition, as bacteria belonging to Synergistes group 4 had high K(m) for acetate and maximum utilization rate, they are more competitive for acetate over Methanosaeta at high acetate concentrations (2.5-10  mM). To our knowledge, it is the first time to report the acetate-utilizing activity of uncultured bacteria belonging to Synergistes group 4 and its competitive significance to acetoclastic methanogen, Methanosaeta.

  12. The deposition of 3C-SiC thin films onto the (111) and (110) faces of Si using pulsed sputtering of a hollow cathode

    Czech Academy of Sciences Publication Activity Database

    Huguenin-Love, J.L.; Lauer, N.T.; Soukup, R. J.; Ianno, N.J.; Kment, Štěpán; Hubička, Zdeněk

    645-648, 1-2 (2010), s. 131-134 ISSN 0255-5476. [International Conference on Silicon Carbide and Related Materials Location /13./. Nurnberg, 11.10.2009-16.10.2009] Institutional research plan: CEZ:AV0Z10100522 Keywords : sputtering * pulse * germanium * 3C Subject RIV: BM - Solid Matter Physics ; Magnetism

  13. Protein replacement by receptor-mediated endocytosis corrects the sensitivity of Fanconi anemia group C cells to mitomycin C

    NARCIS (Netherlands)

    Youssoufian, H; Kruyt, FAE; Li, XT

    1999-01-01

    Current methods for direct gene transfer into hematopoietic cells are inefficient. Here we show that functional complementation of Fanconi anemia (FA) group C cells by protein replacement can be as efficacious as by transfection with wild-type FAC cDNA, We expressed a chimeric protein (called

  14. Relation between the left ventricular mass and the left coronary artery dimensions as determined by 16-channel multidetector CT: comparison between the normotensive group and the hypertensive group

    International Nuclear Information System (INIS)

    Kang, Doo Kyung; Park, Kyung Joo; Tahk, Seung Jea; Kim, Sun Yong

    2006-01-01

    The purpose of this study is to determine the left ventricular mass (LVM) and the left coronary artery dimension and to investigate the relationship between the two values in the normotensive group and hypertensive group with using 16-channel multidetector CT (MDCT). Among the patients who underwent a CT coronary angiogram procedure using 16-channel MDCT at Ajou University Hospital from October 2004 to February 2005, 33 patient became the subjects of this study. These 33 patients showed normal findings without calcification or stenosis of the coronary arteries. The total volume of the left ventricular wall was calculated using work-in-progress cardiac CT reconstruction software. The LVM could then be directly calculated by multiplying the left ventricular muscle volume by the myocardial tissue density, which was assumed to be 1.05 g/cm 3 . The coronary diameter was measured by a fixed threshold method from the transverse reformation images obtained along the long-axis of each coronary artery. We calculated the cross-sectional area (CSA) of the coronary arteries from the equation of π D2/4 (D = diameter). Regression analysis was performed for the relationship between LVM and the left coronary artery dimensions with using a linear least-squares method. Comparison between the normotensive group and the hypertensive group was done using the Student test. The average LVM was 127.9 ± 36.2 g (mean ± standard deviation) and the average left ventricular mass index (LVMI) was 74.7 ± 15.5 g in this study population. The average diameter of the coronary arteries was 4.38 ± 0.69 mm for the left coronary artery. In all the subjects (n = 33, r = 0.67, ρ = 0.000) and the normotensive group (n = 21, r = 0.68, ρ = 0.000), the LVM was significantly correlated with the CSA of the left coronary artery, but not in the hypertensive group (n= 12, r = 0.57, ρ = 0.062). In the hypertensive group, the CSA of the left coronary arteries per 100 g of muscle mass tended to decrease as

  15. Test plan using the HTTR for commercialization of GTHTR300C

    International Nuclear Information System (INIS)

    Tachibana, Yukio; Sakaba, Nariaki; Ohashi, Hirofumi; Sato, Hiroyuki; Ueta, Shohei; Aihara, Jun; Goto, Minoru; Sumita, Junya; Shibata, Taiju; Takamatsu, Kuniyoshi; Inagaki, Yoshiyuki; Kunitomi, Kazuhiko; Nishihara, Tetsuo; Hamamoto, Shimpei; Iyoku, Tatsuo

    2010-02-01

    The High Temperature Engineering Test Reactor (HTTR) is the first High Temperature Gas-cooled Reactor (HTGR) built at the Oarai Research and Development Center of JAEA with thermal power of 30 MW and the maximum reactor outlet coolant temperature of 950degC. The HTTR achieved the first criticality in 1998, the reactor outlet coolant temperature of 950degC in 2004, and 30 days continuous operation in 2007. Since 2002, safety demonstration tests including reactivity insertion tests and coolant flow reduction tests have been conducted to show inherent safety features of the HTGRs by using the HTTR. This report describes full scope of the future feasible test plan mainly using the HTTR. The test items cover fuel performance and radionuclide transport, core physics, reactor thermal hydraulics and plant dynamics, and reactor operations, maintenance, control, etc. The test results will be utilized for realization of Japan's commercial Very High Temperature Reactor (VHTR) system, GTHTR300C. (author)

  16. Multipolarity analysis for {sup 14}C high-energy resonance populated by ({sup 18}O,{sup 16}O) two-neutron transfer reaction

    Energy Technology Data Exchange (ETDEWEB)

    Carbone, D., E-mail: carboned@lns.infn.it; Cavallaro, M.; Bondì, M.; Agodi, C.; Cunsolo, A. [INFN-Laboratori Nazionali del Sud, Catania (Italy); Cappuzzello, F. [INFN-Laboratori Nazionali del Sud, Catania (Italy); Dipartimento di Fisica e Astronomia, Università di Catania, Catania (Italy); Azaiez, F.; Franchoo, S.; Khan, E. [Institut de Physique Nucleaire, Universitè Paris-Sud, Orsay (France); Bonaccorso, A. [INFN-Sezione di Pisa, Pisa (Italy); Fortunato, L. [Dipartimento di Fisica e Astronomia, Università di Padova, Padova (Italy); INFN-Sezione di Padova, Padova (Italy); Foti, A. [Dipartimento di Fisica e Astronomia, Università di Catania, Catania (Italy); INFN-Sezione di Catania, Catania (Italy); Linares, R.; Lubian, J. [Instituto de Fisica, Universidade Federal Fluminense, Niteroi (Brazil); Scarpaci, J. A. [Centre de Sciences Nucleaires et de Sciences de Matieres, Universitè Paris-Sud, Orsay (France); Vitturi, A. [INFN-Sezione di Padova, Padova (Italy); INFN-Sezione di Catania, Catania (Italy)

    2015-10-15

    The {sup 12}C({sup 18}O,{sup 16}O){sup 14}C reaction at 84 MeV incident energy has been explored up to high excitation energy of the residual nucleus thanks to the use of the MAGNEX spectrometer to detect the ejectiles. In the region above the two-neutron separation energy, a resonance has been observed at 16.9 MeV. A multipolarity analysis of the cross section angular distribution indicates an L = 0 character for such a transition.

  17. Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10.

    Science.gov (United States)

    Adams, Mark K; Lee, Seung-Ah; Belyaeva, Olga V; Wu, Lizhi; Kedishvili, Natalia Y

    2017-10-01

    All-trans-retinoic acid (RA) is a bioactive derivative of vitamin A that serves as an activating ligand for nuclear transcription factors, retinoic acid receptors. RA biosynthesis is initiated by the enzymes that oxidize retinol to retinaldehyde. It is well established that retinol dehydrogenase 10 (RDH10, SDR16C4), which belongs to the 16C family of the short chain dehydrogenase/reductase (SDR) superfamily of proteins, is the major enzyme responsible for the oxidation of retinol to retinaldehyde for RA biosynthesis during embryogenesis. However, several lines of evidence point towards the existence of additional retinol dehydrogenases that contribute to RA biosynthesis in vivo. In close proximity to RDH10 gene on human chromosome 8 are located two genes that are phylogenetically related to RDH10. The predicted protein products of these genes, retinol dehydrogenase epidermal 2 (RDHE2, SDR16C5) and retinol dehydrogenase epidermal 2-similar (RDHE2S, SDR16C6), share 59% and 56% sequence similarity with RDH10, respectively. Previously, we showed that the single ortholog of the human RDHE2 and RDHE2S in frogs, Xenopus laevis rdhe2, oxidizes retinol to retinaldehyde and is essential for frog embryonic development. In this study, we explored the potential of each of the two human proteins to contribute to RA biosynthesis. The results of this study demonstrate that human RDHE2 exhibits a relatively low but reproducible activity when expressed in either HepG2 or HEK293 cells. Expression of the native RDHE2 is downregulated in the presence of elevated levels of RA. On the other hand, the protein encoded by the human RDHE2S gene is unstable when expressed in HEK293 cells. RDHE2S protein produced in Sf9 cells is stable but has no detectable catalytic activity towards retinol. We conclude that the human RDHE2S does not contribute to RA biosynthesis, whereas the low-activity RA-sensitive human RDHE2 may have a role in adjusting the cellular levels of RA in accord with

  18. Salivary detection of human Papilloma virus 16 & 18 in pre-malignant and malignant lesions of oral cavity: Is it feasible in Pakistani context of Socio-Cultural Taboos?

    Science.gov (United States)

    Khyani, Iqbal A Muhammad; Qureshi, Masood A; Mirza, Talat; Farooq, M Umar

    2015-01-01

    To evaluate salivary detection of HPV-16 & 18 would be feasible and informative biomarker for oral pre-malignant and malignant lesion in our population. This non-interventional, case control study was carried out at department of E.N.T, Head and Neck Surgery, Dow University of Health Sciences, Dow Medical College and Civil Hospital Karachi, Pakistan between July 2011 to December 2012. Total of 105 cases were recruited. These were divided in three groups 'A', 'B' & 'C' having 35 subjects each. Group'A' constitutes patients having strong clinical evidence of oral pre-malignant lesions (PML). Group 'B' includes histologically proven oral squamous cell carcinoma (OSCC) and Group 'C' comprised disease free subjects as controls. After taking informed consent, relevant clinical history was recorded on institutional approved performa. Saliva from all subjects was procured by standard 'drooling method'. Samples were stored at +4°C and later transferred to Laboratory to store at-20°C before further process. Samples were centrifuged at 4500 rpm for 15 minutes at 4°C. Cell pellets sediments were used for identification of HPV-16 & 18 by real-time PCR method. Data was entered and analysed using SPSS version 16. P-value of 0.05 was taken as standard. In group 'A', HPV-16 was detected in 3 (8.6%) cases while HPV-18 was not detected in any of the subject. In group 'B', HPV-16 was detected in 07 (20%) while HPV-18 was found in 06 (17.1%) cases. Mixed HPV-16 and HPV-18 were found in 02 (5.7%) cases. In group 'C', HPV-16 was detected in 03(8.6%) while HPV-18 was not detected in any of the subjects. Significant relationship was observed between the groups for HPV-18 detection (P= 0.002) while for HPV-16, no significant association was found (P= 0.245). HPV infection for the causation of oral cancer cannot be fully established possibly due to small sample size. More over differences in genetic makeup, environment, indulgence in peculiar risk factor habits, sexual practices and

  19. 29 CFR 2550.401c-1 - Definition of “plan assets”-insurance company general accounts.

    Science.gov (United States)

    2010-07-01

    ... individual and group life, health, disability, and annuity contracts. Experience rated general account... any such assets are plan assets) with the care, skill, prudence and diligence under the circumstances...

  20. Terrestrial Steering Group. 2014. Arctic Terrestrial Biodiversity Monitoring Plan

    DEFF Research Database (Denmark)

    Aastrup, Peter; Aronsson, Mora; Barry, Tom

    capacity and information may be currently available and (b) to outline near-term required steps to begin implementing the plan and reporting on an initial set of Arctic terrestrial biodiversity focal ecosystem component attributes. The specific objectives of the workshop were to: Identify key products...... for TSG for the next two years. Identify key components of a pan-Arctic status report for priority focal ecosystem components (FEC) attributes for policy and decision makers. Develop a prioritized set of activities to meet reporting objectives. Identify key milestones and timelines for the successful...... implementation of the Arctic Terrestrial Biodiversity Monitoring Plan for the next two years. Identify expert networks required for successful implementation of the plan. Identify key gaps and opportunities for the TSG related to plan implementation and identify near-term next steps to address gaps....

  1. Examination of breath alcohol concentration (BrAC) levels, alcohol use disorders identification test (AUDIT-C) classification, and intended plans for getting home among bar-attending college students.

    Science.gov (United States)

    Martin, Ryan J; Chaney, Beth H; Cremeens-Matthews, Jennifer

    2015-06-01

    The college student population is one of the heaviest drinking demographic groups in the US and impaired driving is a serious alcohol-related problem. The objective of this study is to better understand the relationship between alcohol-related behaviors and "plans to get home" among a sample of college students. We conducted four anonymous field studies to examine associations between breath alcohol concentration (BrAC) levels, Alcohol Use Disorders Identification Test (AUDIT-C) classification, and plans for getting home among a sample of bar-attending college students (N = 713). The vast majority of participants in our sample (approximately 95%) were not intending to drive and the average BrAC% of those intending to drive was .041. Our one-way ANOVAs indicated that (1) participants classified by the AUDIT-C as not having an alcohol problem had a significantly lower BrAC% than those classified as having a potential problem and (2) participants planning to drive had a significantly lower BrAC% than those with a plan that did not involve them driving and those without a plan to get home. Although it is encouraging that most of our sample was not intending to drive, it is important to continue to attempt to reduce impaired driving in this population. This study helps college health professionals and administrators to better understand the relationship between alcohol-related behaviors and plans to get home among college students. © American Academy of Addiction Psychiatry.

  2. Efek Pemberian Suntikan Subkutan Vitamin C Terhadap Luka Insisi Dermal

    Directory of Open Access Journals (Sweden)

    Surya Darma

    2014-09-01

    synthesis in wound healing. Method:This experimental study used32 Wistar rats, divided into two group that is 16 rats as control and 16rats as experimental group. All groups underwent 2 cm long incision at the back. Experimental group were given 9mg (0.09ml subcutaneous injection of vitamin c around the wound, while the control group were not. On the fifth day, wound tissue are taken on both sample to check the collagen density microscopically. Result:Collagen density on the fifth day showed significant difference between the two groups(χ2 = 5,833; P<0,05. Discussion:Subcutaneous vitamin C injection around the dermal incision wound is effective in increasing collagen density. Keywords: subcutaneous vitamin C injection,collagen density

  3. Efek Pemberian Suntikan Subkutan Vitamin C Terhadap Luka Insisi Dermal

    Directory of Open Access Journals (Sweden)

    Surya Darma

    2013-09-01

    synthesis in wound healing. Method:This experimental study used32 Wistar rats, divided into two group that is 16 rats as control and 16rats as experimental group. All groups underwent 2 cm long incision at the back. Experimental group were given 9mg (0.09ml subcutaneous injection of vitamin c around the wound, while the control group were not. On the fifth day, wound tissue are taken on both sample to check the collagen density microscopically. Result:Collagen density on the fifth day showed significant difference between the two groups(χ2 = 5,833; P<0,05. Discussion:Subcutaneous vitamin C injection around the dermal incision wound is effective in increasing collagen density. Keywords: subcutaneous vitamin C injection,collagen density

  4. Elastic scattering for 16O + 12C at 140 MeV and 218 MeV

    International Nuclear Information System (INIS)

    Galindo U, A.

    1981-01-01

    In this work, angular distribution of cross sections have been measured for 12 C( 16 O, 16 O) 12 C at two energies. The measurements were carried out in 0.5 0 intervals between 5 0 -19.5 0 C (lab.) at 140 MeV, 4.5 0 -14.5 0 at 218 MeV. An optical model analysis of these strong structure angular distributions was done. Good fits of the data were obtained using the optical model search code GENOA with a full Woods-Saxon potential form. This yielded parameters subject to considerable ambiguities as it is known to occur for strongly absorbed particles. These ambiguities were explored in detail and it was found that both the real and the imaginary parts present some characteristics that have been found before for the real potential (as Igo relation for continous ambiguities and the fact that potentials with different diffusivities tend to have the same value at the strong absorption radii). It was found, among other results, that the real volume integral, the mean square radius, as well as the total reaction cross section (σsub(r)) cannot be determined unambiguously. A strong correlation was found between σsub(r) and the imaginary diffusivity. A systematic study of how the variation of the potential parameters affects the angular distribution is presented and some features of the diffraction structure of the angular distribution are discussed. (author)

  5. [Aging reduces contents of endogenous CO, cAMP and cGMP in rat penile tissues].

    Science.gov (United States)

    Qin, Wen-Bo; Wang, Shu-Qiu; Li, Ming; Kang, Yu-Ming; Gui, Shi-Liang; Chi, Bao-Jin

    2009-02-01

    To explore the relationship of aging with the changes of endogenous carbon monoxide (CO), cGMP and cAMP contents in the penile tissues of rats. Twenty-four male rats were equally divided into an 8-month, a 16-month and a 24-month group, and their penile erection was detected by injecting apomorphine, their penile cavernous body harvested, and the contents of CO, cAPM and cGMP detected by improved dual wavelength spectrophotometry. The contents of CO, cAPM and cGMP were reduced with the increase of age, with statistically significant differences between the three age groups (P < 0.01). Aging significantly decreased the contents of CO, cAMP and cGMP in the penile tissues of the rats, which suggests that aging might play an important role in erectile dysfunction.

  6. 33 CFR 155.1052 - Response plan development and evaluation criteria for vessels carrying group V petroleum oil as a...

    Science.gov (United States)

    2010-07-01

    ... evaluation criteria for vessels carrying group V petroleum oil as a primary cargo. 155.1052 Section 155.1052....1052 Response plan development and evaluation criteria for vessels carrying group V petroleum oil as a primary cargo. (a) Owners and operators of vessels that carry group V petroleum oil as a primary cargo...

  7. Teenagers and emergency contraception in the UK: a focus group study of salient beliefs using concepts from the Theory of Planned Behaviour.

    Science.gov (United States)

    Bayley, Julie; Brown, Katherine; Wallace, Louise

    2009-06-01

    To explore teenagers' beliefs about emergency contraception (EC) within a Theory of Planned Behaviour (TPB) framework. Six single sex focus groups comprising a total of 25 female and 23 male pupils aged 13-16 years conducted in schools in Central England. Attitudes to emergency contraception (EC) were mainly positive about the rewards of avoiding teenage pregnancy. Participants had positive beliefs about the effectiveness of EC, although knowledge of crucial time limits varied. EC use was more socially acceptable than teenage pregnancy, yet both outcomes were perceived negatively. Motivation to comply with social pressure was influenced by the appraisal of individuals' intentions. Participants reported high self efficacy in accessing EC, but had concerns over confidentiality and access. Desire to avoid pregnancy was high in this group, but practical factors and attitudes may be more important for those ambivalent about pregnancy. Adolescents perceive accessing EC as difficult, are concerned about confidentiality, and anticipate negative reactions from staff. Data support the TPB as a suitable framework for understanding attitudes to EC use. Further research should apply quantitative TPB measures to EC use in a wider teenage sample in order to identify potential psychological factors to target in an intervention.

  8. The C. elegans engrailed homolog ceh-16 regulates the self-renewal expansion division of stem cell-like seam cells.

    Science.gov (United States)

    Huang, Xinxin; Tian, E; Xu, Yanhua; Zhang, Hong

    2009-09-15

    Stem cells undergo symmetric and asymmetric division to maintain the dynamic equilibrium of the stem cell pool and also to generate a variety of differentiated cells. The homeostatic mechanism controlling the choice between self-renewal and differentiation of stem cells is poorly understood. We show here that ceh-16, encoding the C. elegans ortholog of the transcription factor Engrailed, controls symmetric and asymmetric division of stem cell-like seam cells. Loss of function of ceh-16 causes certain seam cells, which normally undergo symmetric self-renewal expansion division with both daughters adopting the seam cell fate, to divide asymmetrically with only one daughter retaining the seam cell fate. The human engrailed homolog En2 functionally substitutes the role of ceh-16 in promoting self-renewal expansion division of seam cells. Loss of function of apr-1, encoding the C. elegans homolog of the Wnt signaling component APC, results in transformation of self-renewal maintenance seam cell division to self-renewal expansion division, leading to seam cell hyperplasia. The apr-1 mutation suppresses the seam cell division defect in ceh-16 mutants. Our study reveals that ceh-16 interacts with the Wnt signaling pathway to control the choice between self-renewal expansion and maintenance division and also demonstrates an evolutionarily conserved function of engrailed in promoting cell proliferation.

  9. 75 FR 20423 - Tenth Meeting: RTCA Special Committee 214: Working Group 78: Standards for Air Traffic Data...

    Science.gov (United States)

    2010-04-19

    ... so far SPR & INT documents version H SC-214/WG-78 TORs and Work Plan Review of Position Papers.... Francisco Estrada C., RTCA Advisory Committee. [FR Doc. 2010-8849 Filed 4-16-10; 8:45 am] BILLING CODE 4910...

  10. Planning and managing future space facility projects. [management by objectives and group dynamics

    Science.gov (United States)

    Sieber, J. E.; Wilhelm, J. A.; Tanner, T. A.; Helmreich, R. L.; Burgenbauch, S. F.

    1979-01-01

    To learn how ground-based personnel of a space project plan and organize their work and how such planning and organizing relate to work outcomes, longitudinal study of the management and execution of the Space Lab Mission Development Test 3 (SMD 3) was performed at NASA Ames Research Center. A view of the problems likely to arise in organizations and some methods of coping with these problems are presented as well as the conclusions and recommendations that pertain strictly to SMD 3 management. Emphasis is placed on the broader context of future space facility projects and additional problems that may be anticipated. A model of management that may be used to facilitate problem solving and communication - management by objectives (MBO) is presented. Some problems of communication and emotion management that MBO does not address directly are considered. Models for promoting mature, constructive and satisfying emotional relationships among group members are discussed.

  11. Engineering Task Plan for a vapor treatment system on Tank 241-C-103

    International Nuclear Information System (INIS)

    Conrad, R.B.

    1995-01-01

    This Engineering Task Plan describes tasks and responsibilities for the design, fabrication, test, and installation of a vapor treatment system (mixing system) on Tank 241-C-103. The mixing system is to be installed downstream of the breather filter and will use a mixing blower to reduce the chemical concentrations to below allowable levels

  12. Mixture of trypsin, chymotripsin and papain reduces formation of metastases and extends survival time of C57BL6 mice with syngeneic melanoma B16

    Czech Academy of Sciences Publication Activity Database

    Wald, M.; Olejár, T.; Šebková, V.; Zadinová, M.; Boubelík, Michael; Poučková, P.

    2001-01-01

    Roč. 47, - (2001), s. 16-22 ISSN 0344-5704 Institutional research plan: CEZ:AV0Z5052915 Keywords : proteolytic enzymes * metastasis * melanoma Subject RIV: EC - Immunology Impact factor: 2.170, year: 2001

  13. HMOs and physician recruiting: a survey of problems and methods among group practice plans.

    OpenAIRE

    Fink, R

    1981-01-01

    A mail survey was conducted among 69 group practice health maintenance organizations (HMOs) to collect information on the recruiting of primary care physicians and specialists. In reporting on difficulties in recruiting physicians for primary care, the medical directors of HMOs indicated that the greatest problem was locating obstetrician-gynecologists. Among specialists, recruiting for orthopedists was reported as being most difficult, although plans that employ neurologists and anesthesiolo...

  14. Residential Energy Efficiency Research Planning Meeting Summary Report: Washington, D.C. - October 27-28, 2011

    Energy Technology Data Exchange (ETDEWEB)

    2012-02-01

    This report summarizes key findings and outcomes from the U.S. Department of Energy's Building America Residential Energy Efficiency Research Planning meeting, held on October 28-29, 2011, in Washington, D.C.

  15. On the perfectness of C^{∞,s}-diffeomorphism groups on a foliated manifold

    OpenAIRE

    Jacek Lech

    2008-01-01

    The notion of \\(C^{r,s}\\) and \\(C^{\\infty,s}\\)-diffeomorphisms is introduced. It is shown that the identity component of the group of leaf preserving \\(C^{\\infty,s}\\)-diffeomorphisms with compact supports is perfect. This result is a modification of the Mather and Epstein perfectness theorem.

  16. A family of Mn16 single-molecule magnets from a reductive aggregation route.

    Science.gov (United States)

    King, Philippa; Wernsdorfer, Wolfgang; Abboud, Khalil A; Christou, George

    2004-11-15

    The synthesis and magnetic properties of three isostructural hexadecametallic manganese clusters [Mn(16)O(16)(OMe)(6)(O(2)CCH(2)Ph)(16)(MeOH)(6)] (1), [Mn(16)O(16)(OMe)(6)(O(2)CCH(2)Cl)(16)(MeOH)(6)] (2), and [Mn(16)O(16)(OMe)(6)(O(2)CCH(2)Br)(16)(MeOH)(6)] (3) are reported. The complexes were prepared by a reductive aggregation reaction involving phenylacetic acid, chloroacetic acid or bromoacetic acid, and NBu(n)()(4)MnO(4) in MeOH. Complex 1 crystallizes in the monoclinic space group C2/c and consists of 6 Mn(IV) and 10 Mn(III) ions held together by 14 mu(3)-O(2)(-), 2 mu-O(2)(-), 4 mu-MeO(-), and 2 mu-O(2)CCH(2)Ph(-) groups. The remaining 14 mu-O(2)CCH(2)Ph(-) ligands, 2 mu-MeO(-) groups, and 6 terminal MeOH molecules constitute the peripheral ligation in the complex. Variable-temperature, solid-state dc magnetic susceptibility measurements on 1-3 in the temperature range 5.0-300 K reveal that all three complexes are dominated by intramolecular antiferromagnetic exchange interactions. Low-lying excited states preclude an exact determination of the spin ground state for 1-3 by magnetization measurements. Alternating current susceptibility measurements at zero dc field in the temperature range 1.8-10 K and a 3.5 G ac field oscillating at frequencies in the 5-1488 Hz range display, at temperatures below 3 K, a nonzero, frequency-dependent chi(M)"signal for complexes 1-3, with the peak maxima lying at temperatures less than 1.8 K. Single-crystal magnetization versus dc field scans down to 0.04 K for complex 1 show hysteresis behavior at SMM family. No clear steps characteristic of quantum tunneling of magnetization (QTM) were observed in the hysteresis loops.

  17. Feminist group plans "economic pressure campaign" for access to RU 486.

    Science.gov (United States)

    Jenks, S

    1992-04-15

    A grant for $10 million has boosted the efforts of the Feminist majority Foundation, a Boston activist group committed to bringing RU-486 into the US. The group is planning to research the corporate structure of Hoechst, A.G., the owner of Roussel-Uclaf, and that of its US subsidiary Hoechst Celanese Corporation of Somerville, NJ. Ultimate strategies may include a boycott of Hoechst products in the US, formation of a consortium of small pharmaceutical companies, or of a feminist pharmaceutical firm to research and develop RU-486 or other antiprogestins for the US. The Hoechst Company denies any connection to Roussel-Uclaf. Meanwhile, US researchers have organized in some states to encourage research on the drug, and a bill has been introduced to force the US Food and Drug Administration to lift its ban on importation. An opposition bill to ban importation of RU-486 for any purpose including research has also been introduced by right-to-life forces. New research is underway to test the antineoplastic effects of RU-486 on breast cancer in Canada, and on meningioma in California.

  18. 31 CFR 6.16 - Judicial review.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Judicial review. 6.16 Section 6.16... EQUAL ACCESS TO JUSTICE ACT Procedures for Considering Applications § 6.16 Judicial review. Judicial review of final agency decisions on awards may be sought as provided in 5 U.S.C. 504(c)(2). ...

  19. 26 CFR 54.4980B-2 - Plans that must comply.

    Science.gov (United States)

    2010-04-01

    ... requirements apply only to the type and level of coverage under the cafeteria plan or other flexible benefit... section 125) or other flexible benefit arrangement. (See paragraphs (b) through (e) in Q&A-8 of this... considered to be the provision of health care and so is considered a group health plan. (c) Whether a benefit...

  20. Burning through organizational boundaries? Examining inter-organizational communication networks in policy-mandated collaborative bushfire planning groups

    Science.gov (United States)

    Rachel F. Brummel; Kristen C. Nelson; Pamela J. Jakes

    2012-01-01

    Collaboration can enhance cooperation across geographic and organizational scales, effectively "burning through" those boundaries. Using structured social network analysis (SNA) and qualitative in-depth interviews, this study examined three collaborative bushfire planning groups in New South Wales, Australia and asked: How does participation in policy-...

  1. Dianxianning improved amyloid β-induced pathological characteristics partially through DAF-2/DAF-16 insulin like pathway in transgenic C. elegans.

    Science.gov (United States)

    Zhi, Dejuan; Wang, Dong; Yang, Wenqi; Duan, Ziyun; Zhu, Shuqian; Dong, Juan; Wang, Na; Wang, Ningbo; Fei, Dongqing; Zhang, Zhanxin; Wang, Xin; Wang, Meizhu; Li, Hongyu

    2017-09-12

    Dianxianning (DXN) is a traditional Chinese formula, and has been approved in China for treating epilepsy since 1996. Here anti-Alzheimer's disease activity of DXN has been reported. DXN improved AD-like symptoms of paralysis and 5-HT sensitivity of transgenic Aβ 1-42 C. elegans. In worms, DXN significantly increased Aβ monomers and decreased the toxic Aβ oligomers, thus reducing Aβ toxicity. DXN significantly suppressed the expression of hsp-16.2 induced by juglone, and up-regulated sod-3 expression. These results indicated that DXN increased stress resistance and protected C. elegans against oxidative stress. Furthermore, DXN could significantly promote DAF-16 nuclear translocation, but it did not activate SKN-1. The inhibitory effect of DXN on the Aβ toxicity was significantly reverted by daf-16 RNAi, rather than skn-1 RNAi or hsf-1 RNAi. These results indicated that DAF-16 is at least partially required for the anti-AD effect of DXN. In conclusion, DXN improved Aβ-induced pathological characteristics partially through DAF-2/DAF-16 insulin like pathway in transgenic worms. Together with our data obtained by Morris water maze test, the results showed that DXN markedly ameliorated cognitive performance impairment induced by scopolamine in mice. All the results support that DXN is a potential drug candidate to treat Alzheimer's diseases.

  2. Conversos and Freethought. Searching for Traces (16th and 17th c.

    Directory of Open Access Journals (Sweden)

    Markus Schreiber

    2018-01-01

    Full Text Available In the 16th and 17th centuries, among Iberian New Christians there can be detected some radical manifestations of religious disruption. Following the research of Yitzhak Baer, Carl Gebhardt and most notably Israël S. Révah, these phenomena repeatedly have been linked both to late medieval Jewish «averroism» and the Spinozistic philosophy of the 17th century. However, more perspectives are possible. Here, we would like to present the trends of converso unbelieve with their academic background and in the European context, paying special attention to a group of five New Christian physicians, who, about 1630, together studied at the University of Alcalá de Henares.

  3. Significance of action plans in the development of occupational well-being in the schools of Finland and Estonia.

    Science.gov (United States)

    Laine, Sari; Saaranen, Terhi; Pertel, Tiia; Hansen, Siivi; Lepp, Kädi; Tossavainen, Kerttu

    2016-02-01

    This article is part of a long term project "Promoting the Occupational Well-Being of School Staff-Action Research Project in Finland and Estonia, 2009-2014." The purpose of this article is to describe the significance of action plans in the promotion of the occupational well-being of primary and upper secondary school staff in Finland and Estonia from 2010 to the turn of the year 2011-2012. An electronic open questionnaire was sent to occupational well-being groups in Finland (N=18) and in Estonia (N=39). In Finland, the questionnaire was responded to by 16 (n=16) occupational well-being groups, and in Estonia, by 38 (n=38) groups. The qualitative data were analyzed using the inductive-deductive method and content analysis. The obtained results indicate that the schools had named goals for action plans in all aspects of the promotion of occupational well-being in schools (worker and work, working conditions, professional competence, working community) and that these goals were mainly realized in the schools in a systematic way. Schools felt that the action plan for occupational well-being helped them to set goals for occupational well-being and that the planned actions were realized in a more systematic way than before. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. Rhodium-Catalyzed Regioselective C7-Olefination of Indazoles Using an N-Amide Directing Group.

    Science.gov (United States)

    Guo, Lei; Chen, Yanyu; Zhang, Rong; Peng, Qiujun; Xu, Lanting; Pan, Xianhua

    2017-02-01

    A rhodium-catalyzed regioselective C-H olefination of indazole is described. This protocol relies on the use of an efficient and removable N,N-diisopropylcarbamoyl directing group, which offers facile access to C7-olefinated indazoles with high regioselectivity, ample substrate scope and broad functional group tolerance. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Quasielastic knock out of light fragments from 12C and 16O by intermediate energy pions

    International Nuclear Information System (INIS)

    Abramov, B.M.; Borodin, Yu.A.; Bulychev, S.A.

    2006-01-01

    Using 0.72 GeV s -1 pulse π - -meson beam one studied the quasi-elastic knocking out of deuterons and of tritons from 12 C and 16 O nuclei. One derived the quasi-deuteron intranuclear motion pulse distributions, the residual nucleus excitation energy spectra and the effective number of quasi-deuterons. The parameters of quasi-deuteron intranuclear motion pulse distributions are in line with the measurement results for other beams. The effective numbers of quasi-deuterons in nuclei from 6 Li up to 16 O do not depend on the atomic number. One observed knocking out of tritons from the mentioned nuclei enabling to evaluate the cross section of elastic pion-triton backscattering [ru

  6. INFRARED AND RADIO OBSERVATIONS OF A SMALL GROUP OF PROTOSTELLAR OBJECTS IN THE MOLECULAR CORE, L1251-C

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jungha; Lee, Jeong-Eun [School of Space Research, Kyung Hee University, Yongin-Si, Gyeonggi-Do 446-701 (Korea, Republic of); Choi, Minho; Kang, Miju [Korea Astronomy and Space Science Institute, 776 Daedeokdaero, Yuseong, Daejeon 305-348 (Korea, Republic of); Bourke, Tyler L. [Square Kilometre Array Organisation, Jodrell Bank Observatory, Lower Withington, Cheshire SK11 9DL (United Kingdom); II, Neal J. Evans [Department of Astronomy, University of Texas at Austin, 2515 Speedway, Stop C1400, Austin, TX 78712-1205 (United States); Francesco, James Di [National Research Council Canada, Herzberg Institute of Astrophysics, Victoria, BC (Canada); Cieza, Lucas A. [Universidad Diego Portales, Facultad de Ingeniera, Av. Ejército 441, Santiago (Chile); Dunham, Michael M. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States)

    2015-05-15

    We present a multi-wavelength observational study of a low-mass star-forming region, L1251-C, with observational results at wavelengths from the near-infrared to the millimeter. Spitzer Space Telescope observations confirmed that IRAS 22343+7501 is a small group of protostellar objects. The extended emission in the east–west direction with its intensity peak at the center of L1251A has been detected at 350 and 850 μm with the Caltech Submillimeter Observatory and James Clerk Maxwell telescopes, tracing dense envelope material around L1251A. The single-dish data from the Korean VLBI Network and TRAO telescopes show inconsistencies between the intensity peaks of several molecular emission lines and that of the continuum emission, suggesting complex distributions of molecular abundances around L1251A. The Submillimeter Array interferometer data, however, show intensity peaks of CO 2–1 and {sup 13}CO 2–1 located at the position of IRS 1, which is both the brightest source in the Infrared Array Camera image and the weakest source in the 1.3 mm dust-continuum map. IRS 1 is the strongest candidate for the driving source of the newly detected compact CO 2–1 outflow. Over the entire region (14′ × 14′) of L125l-C, 3 Class I and 16 Class II sources have been detected, including three young stellar objects (YSOs) in L1251A. A comparison between the average projected distance among the 19 YSOs in L1251-C and that among the 3 YSOs in L1251A suggests that L1251-C is an example of low-mass cluster formation where protostellar objects form in a small group.

  7. Present experimental constraints on the total S-factor of 12C(α,γ)16O and proposals for future experiments

    International Nuclear Information System (INIS)

    Buchmann, L.; Azuma, R.E.; Barnes, C.A.; Humblet, J.; Langanke, K.

    1997-01-01

    Because of the critical importance of the 12 C/ 16 O ratio resulting from helium burning to the later evolution of massive stars, R-matrix fits have been made to the available angular distribution data from radiative α-capture and elastic α-scattering on 12 C to estimate the total 12 C(α,γ) 16 O rate at stellar energies. Largely primary data, i.e. energy-dependent differential cross sections, are used in the analysis with all relevant partial waves being fitted simultaneously (surface fits). It is shown that while the E1 part of the reaction is well constrained by a recent experiment on the β-delayed α-particle decay of 16 N only upper limits can be placed on the E2 ground state transition which we take conservatively as S E2 (300)<140 keV b. Monte-Carlo simulations were subsequently carried out to explore what kind of future data could lead to better restrictions on SE2(300). We find that improved elastic scattering data may be the best candidate for such restrictions while improving S(300) with new radiative capture data seems to be much more difficult. (orig.)

  8. Mixture of trypsin, chymotrypsin and papain reduces formation of metastases and extends survival time of C(57)Bl(6) mice with syngeneic melanoma B16

    Czech Academy of Sciences Publication Activity Database

    Wald, M.; Olejar, T.; Šebková, V.; Zadinová, M.; Boubelík, Michael; Poučková, P.

    2001-01-01

    Roč. 47, - (2001), s. S16-S22 ISSN 0344-5704 Institutional research plan: CEZ:AV0Z5052915 Keywords : proteolytic enzymes * proteinases * transplantation Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.170, year: 2001

  9. 2015/16 Annual Service Plan Report

    Science.gov (United States)

    Ministry of Advanced Education, 2016

    2016-01-01

    The Ministry of Advanced Education provides leadership and direction for the world class postsecondary education and training system in British Columbia. Through a range of public and private post-secondary institutions, the Ministry has played a key role in ensuring B.C. has the skilled workers needed to capitalize on economic opportunities and…

  10. Thermochemical Properties Enthalpy, Entropy, and Heat Capacity of C1-C4 Fluorinated Hydrocarbons: Fluorocarbon Group Additivity.

    Science.gov (United States)

    Wang, Heng; Castillo, Álvaro; Bozzelli, Joseph W

    2015-07-23

    Enthalpies of formation for 14 C2–C4 fluorinated hydrocarbons were calculated with nine popular ab initio and density functional theory methods: B3LYP, CBS-QB3, CBS-APNO, M06, M06-2X, ωB97X, G4, G4(MP2)-6X, and W1U via several series of isodesmic reactions. The recommended ideal gas phase ΔHf298° (kcal mol(–1)) values calculated in this study are the following: −65.4 for CH3CH2F; −70.2 for CH3CH2CH2F; −75.3 for CH3CHFCH3; −75.2 for CH3CH2CH2CH2F; −80.3 for CH3CHFCH2CH3; −108.1 for CH2F2; −120.9 for CH3CHF2; −125.8 for CH3CH2CHF2; −133.3 for CH3CF2CH3; −166.7 for CHF3; −180.5 for CH3CF3; −185.5 for CH3CH2CF3; −223.2 for CF4; and −85.8 for (CH3)3CF. Entropies (S298° in cal mol(–1) K(–1)) were estimated using B3LYP/6-31+G(d,p) computed frequencies and geometries. Rotational barriers were determined and hindered internal rotational contributions for S298°, and Cp(T) were calculated using the rigid rotor harmonic oscillator approximation, with direct integration over energy levels of the intramolecular rotation potential energy curve. Thermochemical properties for the fluorinated carbon groups C/C/F/H2, C/C2/F/H, C/C/F2/H, C/C2/F2, and C/C/F3 were derived from the above target fluorocarbons. Previously published enthalpies and groups for 1,2-difluoroethane, 1,1,2-trifluoroethane, 1,1,2,2-tetrafluoroethane, 1,1,1,2-tetrafluoroethane, 1,1,1,2,2-pentafluoroethane, 2-fluoro-2-methylpropane that were previously determined via work reaction schemes are revised using updated reference species values. Standard deviations are compared for the calculation methods.

  11. Highlights of Astronomy, Vol. 16

    Science.gov (United States)

    Montmerle, Thierry

    2015-04-01

    Part I. Invited Discourses: 1. The Herschel view of star formation; 2. Past, present and future of Chinese astronomy; 3. The zoo of galaxies; 4. Supernovae, the accelerating cosmos, and dark energy; Part II. Joint Discussion: 5. Very massive stars in the local universe; 6. 3-D views of the cycling Sun in stellar context; 7. Ultraviolet emission in early-type galaxies; 8. From meteors and meteorites to their parent bodies: current status and future developments; 9. The connection between radio properties and high-energy emission in AGNs; 10. Space-time reference systems for future research; Part III. Special Sessions: 11. Origin and complexity of massive star clusters; 12. Cosmic evolution of groups and clusters of galaxies; 13. Galaxy evolution through secular processes; 14. New era for studying interstellar and intergalactic magnetic fields; 15. The IR view of massive stars: the main sequence and beyond; 16. Science with large solar telescopes; 17. The impact hazard: current activities and future plans; 18. Calibration of star-formation rate measurements across the electromagnetic spectrum; 19. Future large scale facilities; 20. Dynamics of the star-planet relations strategic plan and the Global Office of Astronomy for Development; 21. Strategic plan and the Global Office of Astronomy for Development; 22. Modern views of the interstellar medium; 23. High-precision tests of stellar physics from high-precision photometry; 24. Communicating astronomy with the public for scientists; 25. Data intensive astronomy; 26. Unexplained spectral phenomena in the interstellar medium; 27. Light pollution: protecting astronomical sites and increasing global awareness through education.

  12. Significant difference in p53 and p21 protein immunoreactivity in HPV 16 positive and HPV negative breast carcinomas

    International Nuclear Information System (INIS)

    Hennig, E.M.; Norwegian Radium Hospital, Oslo; Kvinnsland, S.; Holm, R.; Nesland, J.M.

    1999-01-01

    Human papillomavirus (HPV) 16 has previously been found in 19/41 breast carcinomas (46%) in women with a history of HPV 16 positive CIN III lesions. There was no significant difference in distribution of histological subtypes, mean or median tumour diameter or number of regional lymph node metastases in the HPV positive and HPV negative breast carcinoma groups. P53, p21 and c-erbB-2 proteins were analyzed by immunohistochemistry in the HPV 16 positive and HPV negative breast carcinomas. There was a significant difference in p53 and p21 protein immunoreactivity between HPV 16 positive and HPV negative breast carcinomas (p=0.0091 and p=0.0040), with a significant less detectable p53 and p21 protein immunoreactivity in the HPV 16 positive cases. There was also a significant difference in the coexpression of p53/p21 between the HPV 16 positive and HPV 16 negative breast carcinomas (p=0.002). No significant difference in immunostaining for c-erbB-2 protein in the two groups was found (p=0.15), or for the coexpression of p53/c-erbB-2 (p=0.19). The significantly lower expression of p53 and p21 proteins in HPV 16 positive than in HPV 16 negative breast carcinomas supports the hypothesis of inactivation and degradation of wild-type p53 proteins by HPV 16 E6 and that p53 mutation is not necessary for transformation in the HPV 16 positive cases. (orig.)

  13. The C21-formyl group in chlorophyll f originates from molecular oxygen.

    Science.gov (United States)

    Garg, Harsh; Loughlin, Patrick C; Willows, Robert D; Chen, Min

    2017-11-24

    Chlorophylls (Chls) are the most important cofactors for capturing solar energy to drive photosynthetic reactions. Five spectral types of Chls have been identified to date, with Chl f having the most red-shifted absorption maximum because of a C2 1 -formyl group substitution of Chl f However, the biochemical provenance of this formyl group is unknown. Here, we used a stable isotope labeling technique ( 18 O and 2 H) to determine the origin of the C2 1 -formyl group of Chl f and to verify whether Chl f is synthesized from Chl a in the cyanobacterial species Halomicronema hongdechloris. In the presence of either H 2 18 O or 18 O 2 , the origin of oxygen atoms in the newly synthesized chlorophylls was investigated. The pigments were isolated with HPLC, followed by MS analysis. We found that the oxygen atom of the C2 1 -formyl group originates from molecular oxygen and not from H 2 O. Moreover, we examined the kinetics of the labeling of Chl a and Chl f from H. hongdechloris grown in 50% D 2 O-seawater medium under different light conditions. When cells were shifted from white light D 2 O-seawater medium to far-red light H 2 O-seawater medium, the observed deuteration in Chl f indicated that Chl(ide) a is the precursor of Chl f Taken together, our results advance our understanding of the biosynthesis pathway of the chlorophylls and the formation of the formyl group in Chl f . © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  14. Planning and management of E-commerce Website : Guide for startup B2C E-commerce companies

    OpenAIRE

    Wang, Ying

    2016-01-01

    The purpose of this thesis is to help startup B2C E-commerce companies to plan and manage e-commerce website. This thesis is intended to equip current and future e-commerce managers or entrepreneurs with some basic knowledge and practical skills to help them navigate their organisations towards e-business. It does not have any specific commissioner. Thesis will contain most aspects when plan and manage e-commerce website for startups.

  15. Plan estratégico Limpi Max S.A.C. 2015-2019

    OpenAIRE

    Aniceto Prado, Fabiola Virginia; Barcelona Zakimi, Antoane Andre; Tokashiki Zakimi, Javier Elias; Yutaka Yino Oshiro, Daniel Alberto

    2015-01-01

    El presente plan estratégico ha sido elaborado para la empresa Limpi Max S.A.C. para el periodo comprendido entre los años 2015 a 2019, cuya actividad económica está especializada en el cristalizado de superficies y suelos calcáreos. El mercado del cristalizado se enfoca en centros comerciales, tiendas por departamento y hoteles que cuenten con las superficies mencionadas líneas arriba. El mayor problema que enfrenta Limpi Max es la reducida o nula cultura empresarial en nuestro país de reali...

  16. ToF-SIMS analysis of a polymer microarray composed of poly(meth)acrylates with C6 derivative pendant groups.

    Science.gov (United States)

    Hook, Andrew L; Scurr, David J

    2016-04-01

    Surface analysis plays a key role in understanding the function of materials, particularly in biological environments. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) provides highly surface sensitive chemical information that can readily be acquired over large areas and has, thus, become an important surface analysis tool. However, the information-rich nature of ToF-SIMS complicates the interpretation and comparison of spectra, particularly in cases where multicomponent samples are being assessed. In this study, a method is presented to assess the chemical variance across 16 poly(meth)acrylates. Materials are selected to contain C 6 pendant groups, and ten replicates of each are printed as a polymer microarray. SIMS spectra are acquired for each material with the most intense and unique ions assessed for each material to identify the predominant and distinctive fragmentation pathways within the materials studied. Differentiating acrylate/methacrylate pairs is readily achieved using secondary ions derived from both the polymer backbone and pendant groups. Principal component analysis (PCA) is performed on the SIMS spectra of the 16 polymers, whereby the resulting principal components are able to distinguish phenyl from benzyl groups, mono-functional from multi-functional monomers and acrylates from methacrylates. The principal components are applied to copolymer series to assess the predictive capabilities of the PCA. Beyond being able to predict the copolymer ratio, in some cases, the SIMS analysis is able to provide insight into the molecular sequence of a copolymer. The insight gained in this study will be beneficial for developing structure-function relationships based upon ToF-SIMS data of polymer libraries. © 2016 The Authors Surface and Interface Analysis Published by John Wiley & Sons Ltd.

  17. 48 CFR 52.219-16 - Liquidated Damages-Subcontracting Plan.

    Science.gov (United States)

    2010-10-01

    ... following clause: Liquidated Damages—Subcontracting Plan (JAN 1999) (a) Failure to make a good faith effort... has failed to make such good faith effort, the Contracting Officer shall give the Contractor written notice specifying the failure and permitting the Contractor to demonstrate what good faith efforts have...

  18. Students Working Online for Group Projects: A Test of an Extended Theory of Planned Behaviour Model

    Science.gov (United States)

    Cheng, Eddie W. L.

    2017-01-01

    This study examined an extended theory of planned behaviour (TPB) model that specified factors affecting students' intentions to collaborate online for group work. Past behaviour, past experience and actual behavioural control were incorporated in the extended TPB model. The mediating roles of attitudes, subjective norms and perceived behavioural…

  19. A novel HPV 16 L1-based chimeric virus-like particle containing E6 and E7 seroreactive epitopes permits highly specific detection of antibodies in patients with CIN 1 and HPV-16 infection

    Directory of Open Access Journals (Sweden)

    Santiago-Osorio Edelmiro

    2011-02-01

    Full Text Available Abstract Background The presence of IgG antibodies to HPV-16 L1-virus like particles (VLPs in serum has been reported as a result of persistent exposure to the virus and as a marker of disease progression. However, detection of VLP-specific antibodies in sera does not always indicate a malignant lesion as positive results may also be due to a nonmalignant viral infection. Furthermore, malignant lesions are associated with an increased antibody titer for E6 and E7 proteins. The aim of this study was to develop an ELISA using a novel chimeric virus-like particle (cVLP encoding an L1 protein fused with a string of HPV-16 E6 and E7 seroreactive epitopes to its C-terminus to be used for detection of HPV-16 specific antibodies in patients with cervical intraepithelial lesion grade 1 (CIN 1. Results The sera of 30 patients with CIN 1 who also tested positive for HPV-16 DNA and of 30 age-matched normal donors negative for HPV infection were tested for the presence of IgG antibodies specific for either VLP-L1 (HPV-16 L1, gVLP (derived from Gardasil, or cVLP by ELISA. The cVLP-reactive sera yielded two distinct groups of results: (H reactivity levels that presented very strong cVLP-specific titers, and (L reactivity levels with significantly lower titers similar to those obtained with VLP-L1 and gVLP antigens. Additionally, the sera that presented the higher cVLP titers closely matched those that had significantly stronger reactivity to E6 and E7 epitopes. Interestingly, the samples with the highest titers corresponded to patients with the higher numbers of sexual partners and pregnancies. On the other hand only 4 out of the 12 sera that harbored antibodies with VLP neutralizing ability corresponded to the group with high cVLP antibody titers. Conclusion We report for the first time that chimeric particles containing HPV-16 L1 protein fused with E6 and E7 seroreactive epitopes enable much better detection of IgG antibodies in the sera of CIN 1 patients

  20. The 13C(α,n)16O reaction as a neutron source for the s-process in AGB low-mass stars

    International Nuclear Information System (INIS)

    Trippella, O.; Busso, M.; La Cognata, M.; Spitaleri, C.; Guardo, G. L.; Lamia, L.; Puglia, S. M.R.; Romano, S.; Spartà, R.; Kiss, G. G.; Rogachev, G. V.; Avila, M.; Koshchiy, E.; Kuchera, A.; Santiago, D.; Mukhamedzhanov, A. M.; Maiorca, E.; Palmerini, S.

    2014-01-01

    The 13 C(α,n) 16 O reaction is considered to be the most important neutron source for producing the main component of the s-process in low mass stars. In this paper we focus our attention on two of the main open problems concerning its operation as a driver for the slow neutron captures. Recently, a new measurement of the 13 C(α,n) 16 O reaction rate was performed via the Trojan Horse Method greatly increasing the accuracy. Contemporarily, on the modelling side, magnetic mechanisms were suggested to justify the production of the 13 C pocket, thus putting the s-process in stars on safe physical ground. These inputs allow us to reproduce satisfactorily the solar distribution of elements

  1. The differences in heparin binding for the C-terminal basic-sequence-rich peptides of HPV-16 and HPV-18 capsid protein L1

    International Nuclear Information System (INIS)

    Sun Jian; Yu Jisheng; Yu Zhiwu; Zha Xiao; Wu Yuqing

    2012-01-01

    Graphial abstract: The differences in heparin binding for the C-terminal basic-sequence-rich peptides of HPV-16 and HPV-18 capsid protein L1. Highlights: ► Several driving forces contribute to the interaction between heparin and peptides. ► C-terminal of HPV L1 is a potential candidate for the attachment to host cells. ► The C-terminal peptides of HPV-16 and -18 L1 have different heparin-binding. ► The different heparin-binding provides an explanation for the distinct prevalences. - Abstract: The high-risk types of human papillomaviruses (HPV) HPV-16 and -18 are the predominant types associated with cervical cancer. HPV-16 and -18 account for about 50% and 20%, respectively, of cervical cancers worldwide. While the reason and molecular mechanism of the distinct prevalence and distributions between them remain poorly understood, the binding affinity of cell surface receptor with capsid proteins, especially L1, may be involved. We examined heparin binding with two synthetic peptides corresponding to the 14 amino acid C-terminal peptides of HPV-16 and -18 L1 with the goal of comparing the equivalent residues in different HPV types. Using isothermal titration calorimetry (ITC) and static right-angle light scattering (SLS), we determined the binding constant K, reaction enthalpy ΔH, and other thermodynamic parameters in the interaction. Especially, we assessed the role of specific residues in binding with heparin by comparing the NMR spectra of free and heparin-bound peptides.

  2. Task Group on Safety Margins Action Plan (SMAP). Safety Margins Action Plan - Final Report

    International Nuclear Information System (INIS)

    Hrehor, Miroslav; Gavrilas, Mirela; Belac, Josef; Sairanen, Risto; Bruna, Giovanni; Reocreux, Michel; Touboul, Francoise; Krzykacz-Hausmann, B.; Park, Jong Seuk; Prosek, Andrej; Hortal, Javier; Sandervaag, Odbjoern; Zimmerman, Martin

    2007-01-01

    The international nuclear community has expressed concern that some changes in existing plants could challenge safety margins while fulfilling all the regulatory requirements. In 1998, NEA published a report by the Committee on Nuclear Regulatory Activities on Future Nuclear Regulatory Challenges. The report recognized 'Safety margins during more exacting operating modes' as a technical issue with potential regulatory impact. Examples of plant changes that can cause such exacting operating modes include power up-rates, life extension or increased fuel burnup. In addition, the community recognized that the cumulative effects of simultaneous changes in a plant could be larger than the accumulation of the individual effects of each change. In response to these concerns, CSNI constituted the safety margins action plan (SMAP) task group with the following objectives: 'To agree on a framework for integrated assessments of the changes to the overall safety of the plant as a result of simultaneous changes in plant operation / condition; To develop a CSNI document which can be used by member countries to assess the effect of plant change on the overall safety of the plant; To share information and experience.' The two approaches to safety analysis, deterministic and probabilistic, use different methods and have been developed mostly independently of each other. This makes it difficult to assure consistency between them. As the trend to use information on risk (where the term risk means results of the PSA/PRA analysis) to support regulatory decisions is growing in many countries, it is necessary to develop a method of evaluating safety margin sufficiency that is applicable to both approaches and, whenever possible, integrated in a consistent way. Chapter 2 elaborates on the traditional view of safety margins and the means by which they are currently treated in deterministic analyses. This chapter also discusses the technical basis for safety limits as they are used today

  3. Incomplete momentum transfer components in /sup 16/O + /sup 12/C Fusion at 20 MeV/A

    Energy Technology Data Exchange (ETDEWEB)

    Menchaca-Rocha, A.; Brandan, M.E. (Grenoble-1 Univ., 38 (France). Inst. des Sciences Nucleaires); Dacal, A.; Galindo, A.; Mahoney, J.; Murphy, M.; Rae, W.D.M. (California Univ., Berkeley (USA). Lawrence Berkeley Lab.)

    1983-01-27

    The energy spectra of Z = 3-9 particles from reactions induced by 20 MeV/A /sup 16/O on /sup 12/C have been measured. The systematics found from the fusion-like residues clearly deviate from those expected for complete fusion, giving evidence for important incomplete momentum transfer components.

  4. Gulf Regional Planning Commission scenario planning workshop : sponsored by the Federal Highway Administration

    Science.gov (United States)

    2016-03-01

    This report summarizes noteworthy practices shared during a scenario planning workshop, hosted by the Gulf Regional Planning Commission, on March 15-16, 2016, in Biloxi, Mississippi. The Federal Highway Administration (FHWA) sponsored this event as p...

  5. Three-dimensional preservation of cellular and subcellular structures suggests 1.6 billion-year-old crown-group red algae

    DEFF Research Database (Denmark)

    Bengtson, Stefan; Sallstedt, Therese; Belivanova, Veneta

    2017-01-01

    The ~1.6 Ga Tirohan Dolomite of the Lower Vindhyan in central India contains phosphatized stromatolitic microbialites. We report from there uniquely well-preserved fossils interpreted as probable crown-group rhodophytes (red algae). The filamentous form Rafatazmia chitrakootensis n. gen, n. sp. has....... The wider affinities of Denaricion are uncertain. Ramathallus lobatus n. gen., n. sp. is a lobate sessile alga with pseudoparenchymatous thallus, “cell fountains,” and apical growth, suggesting florideophycean affinity. If these inferences are correct, Rafatazmia and Ramathallus represent crown......-group multicellular rhodophytes, antedating the oldest previously accepted red alga in the fossil record by about 400 million years....

  6. The Need for Strategic Planning for Nuclear Power Plant I and C Upgrades

    International Nuclear Information System (INIS)

    Hill, J. Douglas; Moore, Paul

    2002-01-01

    Nuclear power plants rely on Instrumentation and Control (I and C) systems for control, monitoring and protection of the plant. The original, analog designs used in most nuclear plants have become or soon will be obsolete, forcing plants to turn to digital technology. Many factors affect the design of replacement equipment, including long-term and short-term economics, regulatory issues, and the way the plant operates on a day-to-day basis. The first step to all modernization projects should involve strategic planning, to ensure that the overall long and short-term goals of the plant are met. Strategic planning starts with a thorough evaluation of the existing plant control systems, the available options, and the benefits and consequences of these options. (authors)

  7. ON THE MEASUREMENT OF THE 13C(α, n)16O S-FACTOR AT NEGATIVE ENERGIES AND ITS INFLUENCE ON THE s-PROCESS

    International Nuclear Information System (INIS)

    La Cognata, M.; Spitaleri, C.; Trippella, O.; Kiss, G. G.; Guardo, G. L.; Puglia, S. M. R.; Romano, S.; Spartà, R.; Rogachev, G. V.; Avila, M.; Koshchiy, E.; Kuchera, A.; Santiago, D.; Mukhamedzhanov, A. M.; Lamia, L.

    2013-01-01

    The 13 C(α, n) 16 O reaction is the neutron source for the main component of the s-process, responsible for the production of most of the nuclei in the mass range 90 ∼ 8 K, corresponding to an energy interval where the 13 C(α, n) 16 O reaction is effective in the range of 140-230 keV. In this regime, the astrophysical S(E)-factor is dominated by the –3 keV sub-threshold resonance due to the 6.356 MeV level in 17 O, giving rise to a steep increase in the S-factor. Its contribution is still controversial as extrapolations, e.g., through the R-matrix and indirect techniques such as the asymptotic normalization coefficient (ANC), yield inconsistent results. The discrepancy amounts to a factor of three or more precisely at astrophysical energies. To provide a more accurate S-factor at these energies, we have applied the Trojan horse method (THM) to the 13 C( 6 Li, n 16 O)d quasi-free reaction. The ANC for the 6.356 MeV level has been deduced through the THM as well as the n-partial width, allowing us to attain unprecedented accuracy for the 13 C(α, n) 16 O astrophysical factor. A larger ANC for the 6.356 MeV level is measured with respect to the ones in the literature, (C-tilde α 13 C 17O(1/2+)2 = 7.7 ± 0.3 stat -1.5 +1. |6 norm fm –1 , yet in agreement with the preliminary result given in our preceding letter, indicating an increase of the 13 C(α, n) 16 O reaction rate below about 8 × 10 7 K if compared with the recommended values. At ∼10 8 K, our reaction rate agrees with most of the results in the literature and the accuracy is greatly enhanced thanks to this innovative approach

  8. The use of comet assay to assess DNA integrity of boar spermatozoa following liquid preservation at 5 degrees C and 16 degrees C.

    Directory of Open Access Journals (Sweden)

    J Strzezek

    2004-03-01

    Full Text Available The comet assay, under neutral conditions, allows the assessment of DNA integrity influenced by sperm ageing, which is manifested in DNA double-strand breaks. Here, we attempted to use a modified neutral comet assay test (single-cell gel electrophoresis, to our knowledge for the first time, to assess DNA integrity of boar spermatozoa during liquid storage for 96 h at 5 degrees C and 16 degrees C. In this comet assay protocol we used 2% beta-mercaptoethanol prior to the lysis procedure, to aid in removing nuclear proteins. Ejaculates from 3 boars (designated A, C and G were diluted with a standard semen extender, Kortowo-3 (K-3, which was supplemented with lipoprotein fractions extracted from hen egg yolk (LPFh or ostrich egg yolk (LPFo. Irrespective of the extender type, the percentage of comet-detected spermatozoa with damaged DNA increased gradually during prolonged storage at 5 degrees C and 16 degrees C. Spermatozoa stored in K-3 extender exhibited elevated levels of DNA damage at both storage temperatures. Significant differences in DNA damage among the boars were more pronounced during storage in LPF-based extenders at 5 degrees C: spermatozoa of boars A and G were less susceptible to DNA damage. The percent of tail DNA in comets was lower in LPF-based extenders, and there were individual variations among the boars. We observed that changes in DNA integrity were dependent on the extender type and storage temperature. A higher level of DNA instability was observed in K-3 extended semen compared with K-3/LPFh or K-3/LPFo extended semen during storage at 5 degrees C. No significant difference in the level of DNA damage between K-3/LPFh and K-3/LPFo was observed. It seems that a long-term storage can affect genomic integrity of boar spermatozoa. The modified neutral comet assay can be used to detect low levels of DNA damage in boar spermatozoa during liquid preservation. Therefore, screening for sperm DNA damage may be used as an additional

  9. The use of comet assay to assess DNA integrity of boar spermatozoa following liquid preservation at 5 degrees C and 16 degrees C.

    Science.gov (United States)

    Fraser, L; Strzezek, J

    2004-01-01

    The comet assay, under neutral conditions, allows the assessment of DNA integrity influenced by sperm ageing, which is manifested in DNA double-strand breaks. Here, we attempted to use a modified neutral comet assay test (single-cell gel electrophoresis), to our knowledge for the first time, to assess DNA integrity of boar spermatozoa during liquid storage for 96 h at 5 degrees C and 16 degrees C. In this comet assay protocol we used 2% beta-mercaptoethanol prior to the lysis procedure, to aid in removing nuclear proteins. Ejaculates from 3 boars (designated A, C and G) were diluted with a standard semen extender, Kortowo-3 (K-3), which was supplemented with lipoprotein fractions extracted from hen egg yolk (LPFh) or ostrich egg yolk (LPFo). Irrespective of the extender type, the percentage of comet-detected spermatozoa with damaged DNA increased gradually during prolonged storage at 5 degrees C and 16 degrees C. Spermatozoa stored in K-3 extender exhibited elevated levels of DNA damage at both storage temperatures. Significant differences in DNA damage among the boars were more pronounced during storage in LPF-based extenders at 5 degrees C: spermatozoa of boars A and G were less susceptible to DNA damage. The percent of tail DNA in comets was lower in LPF-based extenders, and there were individual variations among the boars. We observed that changes in DNA integrity were dependent on the extender type and storage temperature. A higher level of DNA instability was observed in K-3 extended semen compared with K-3/LPFh or K-3/LPFo extended semen during storage at 5 degrees C. No significant difference in the level of DNA damage between K-3/LPFh and K-3/LPFo was observed. It seems that a long-term storage can affect genomic integrity of boar spermatozoa. The modified neutral comet assay can be used to detect low levels of DNA damage in boar spermatozoa during liquid preservation. Therefore, screening for sperm DNA damage may be used as an additional test of sperm

  10. [Automated management of the Center of Transfusion Blood Bank equipped with Autogrouper 16 C].

    Science.gov (United States)

    Girard, M; Connes, Y; Picot, P

    1981-11-01

    We describe in this paper a first processing of direct connection and data management from the Autogrouper 16 C. It bas been used since November 1980 in the Centre Départemental de Tranfusion Sanguine des Hauts-de-Seine. The automation of validation procedures, updating blood donors' file and labelling blood units allows the suppression of clerical errors that are the major cause of Trannsfusion accidents. The progressive development of programming lets a good adaptation of working methods and makes the setting of the system much easier in the Blood Bank.

  11. Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition.

    Science.gov (United States)

    Musante, Veronica; Li, Lu; Kanyo, Jean; Lam, Tukiet T; Colangelo, Christopher M; Cheng, Shuk Kei; Brody, A Harrison; Greengard, Paul; Le Novère, Nicolas; Nairn, Angus C

    2017-06-14

    ARPP-16, ARPP-19, and ENSA are inhibitors of protein phosphatase PP2A. ARPP-19 and ENSA phosphorylated by Greatwall kinase inhibit PP2A during mitosis. ARPP-16 is expressed in striatal neurons where basal phosphorylation by MAST3 kinase inhibits PP2A and regulates key components of striatal signaling. The ARPP-16/19 proteins were discovered as substrates for PKA, but the function of PKA phosphorylation is unknown. We find that phosphorylation by PKA or MAST3 mutually suppresses the ability of the other kinase to act on ARPP-16. Phosphorylation by PKA also acts to prevent inhibition of PP2A by ARPP-16 phosphorylated by MAST3. Moreover, PKA phosphorylates MAST3 at multiple sites resulting in its inhibition. Mathematical modeling highlights the role of these three regulatory interactions to create a switch-like response to cAMP. Together, the results suggest a complex antagonistic interplay between the control of ARPP-16 by MAST3 and PKA that creates a mechanism whereby cAMP mediates PP2A disinhibition.

  12. Electronic structure of low work function electrodes modified by C{sub 16}H{sub 33}SH

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyunbok [Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA, 01003 (United States); Cho, Sang Wan, E-mail: dio8027@yonsei.ac.kr [Department of Physics, Yonsei University, 1 Yonseidae-gil, Wonju-si, Gangwon-do, 220-710 (Korea, Republic of); Park, Sang Han; Cho, Mann-Ho; Yi, Yeonjin [Institute of Physics and Applied Physics, Yonsei University, 50 Yonsei-ro, Seodaemoon-Gu, Seoul, 120-749 (Korea, Republic of)

    2014-10-15

    Highlights: • The electronic structure of pentacene/C{sub 16}H{sub 33}SH/Au is investigated. • The work function of Au is significantly decreased with C{sub 16}H{sub 33}SH treatment. • The reduced work function is attributed to its permanent dipole moment. - Abstract: Organic and printed electronics technologies require electrodes with low work functions to facilitate the transport of electrons in and out of various optoelectronic devices. We show that the surface modifier of 1-hexadecanethiol reduces the work function of conductors using in situ ultraviolet photoemission spectroscopy, and we combine experimental and theoretical methods to investigate the origin of the work function changes. The interfacial electronic structures of pentacene/1-hexadecanethiol/Au were investigated via in situ ultraviolet photoemission spectroscopy and X-ray photoemission spectroscopy in order to understand the change in the carrier injection barrier and chemical reactions upon surface modification. Theoretical calculations using density functional theory were also performed to understand the charge distribution of 1-hexadecanethiol, which affects the reduction of the work function. The 1-hexadecanethiol surface modifier is processed in air from solution, providing an appealing alternative to chemically-reactive low-work-function metals.

  13. First Accurate Normalization of the $\\beta$-delayed $\\alpha$ Decay of $^{16}$N and Implications for the $^{12}$C$(\\alpha,\\gamma)^{16}$O Astrophysical Reaction Rate arXiv

    CERN Document Server

    Kirsebom, O.S.; Lica, R.; Munch, M.; Riisager, K.; Fynbo, H.O.U.; Borge, M.J.G.; Madurga, M.; Marroquin, I.; Andreyev, A.N.; Berry, T.A.; Christensen, E.R.; Fernández, P. Díaz; Doherty, D.T.; Van Duppen, P.; Fraile, L.M.; Gallardo, M.C.; Greenlees, P.T.; Harkness-Brennan, L.J.; Hubbard, N.; Huyse, M.; Jensen, J.H.; Johansson, H.; Jonson, B.; Judson, D.S.; Konki, J.; Lazarus, I.; Lund, M.V.; Marginean, N.; Marginean, R.; Perea, A.; Mihai, C.; Negret, A.; Page, R.D.; Pucknell, V.; Rahkila, P.; Sorlin, O.; Sotty, C.; Swartz, J.A.; Sørensen, H.B.; Törnqvist, H.; Vedia, V.; Warr, N.; De Witte, H.

    The $^{12}$C$(\\alpha,\\gamma)^{16}$O reaction plays a central role in astrophysics, but its cross section at energies relevant for astrophysical applications is only poorly constrained by laboratory data. The reduced $\\alpha$ width, $\\gamma_{11}$, of the bound $1^-$ level in $^{16}$O is particularly important to determine the cross section. The magnitude of $\\gamma_{11}$ is determined via sub-Coulomb $\\alpha$-transfer reactions or the $\\beta$-delayed $\\alpha$ decay of $^{16}$N, but the latter approach is presently hampered by the lack of sufficiently precise data on the $\\beta$-decay branching ratios. Here we report improved branching ratios for the bound $1^-$ level and for $\\beta$-delayed $\\alpha$ emission. In the case of the $\\beta$-delayed $\\alpha$ branch, we find a $5\\sigma$ deviation from the literature value. With our new branching ratios, the constraints imposed on $\\gamma_{11}$ by the $\\beta\\alpha$-decay and $\\alpha$-transfer data are of similar precision and, for the first time, in good agreement. Th...

  14. /sup 58/Ni(/sup 16/O, /sup 12/C)/sup 62/Zn reaction at an incident energy 80 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Okuma, Yasuhiko [Osaka Univ., Suita (Japan). Research Center for Nuclear Physics; Motobayashi, Tooru; Takimoto, Kiyohiko; Shimoura, Susumu; Ogino, Kouya; Fukada, Mamoru; Suehiro, Teruo; Matsuki, Seishi; Yanabu, Takuji

    1983-03-01

    Cross section angular distributions for the /sup 16/O + /sup 58/Ni elastic scattering and the /sup 58/Ni(/sup 16/O, /sup 12/C)/sup 62/Zn- 3.8416 MeV reaction leading to the discrete and continuum states at an incident energy Esub(lab)(/sup 16/O) = 80 MeV have been measured. The eight low-lying single and double energy levels were observed in the energy spectra of the /sup 58/Ni(/sup 16/O, /sup 12/C)/sup 62/Zn reaction. Populations of these levels have the cross sections of 1-200 ..mu..b/sr. The ground state cross section was proved to change with the incident energy by comparing the present data with the other 46 and 60 MeV data. The cross section angular distribution for the ground state transition changes also with the incident energy. The data points for the 46 MeV show a typical bell shape angular distribution. The angular distribution for the 60 MeV reveals a forward peaked and pronounced oscillation pattern, while that for the 80 MeV shows an oscillation damping with the angle and then a monotonous fall on the angle. Optical model parameters were deduced from the best fit to the measurements of the /sup 16/O + /sup 58/Ni elastic scattering. The EFR-DWBA calculations of the (/sup 16/O, /sup 12/C) results were performed with reasonable fits for the cross section angular distributions of observed energy levels. The optical model parameters giving good representations of the ..cap alpha..-transfer data have the property that the real diffuseness parameter has a large value almost equal to the radius parameter. The inclusion of Coulomb correction in the transfer interaction causes a reduction of 0.9 times in cross section, but no change in angular distribution. The dependence of the angular distribution shape on the incident energy can be reproduced by the EFR-DWBA calculation even if only one parameter set is used in the calculation over the wide incident energy range.

  15. Comparison of the elastic and inelastic scattering between 152Sm + 12C and 148Nd + 16O

    International Nuclear Information System (INIS)

    Zhao Kui; Lu Xiuqin; Cheng Yehao; Li Qingli; Li Min; Li Zhichang; Guo Jiyu; Li Shuyuan; Zhang Qinghua; Song Xiaobin; Jiang Chenglie

    1994-01-01

    Angular distributions of elastic and inelastic scattering have been measured for 152 Sm+ 12 C at 63.2 MeV and 148 Nd+ 16 O at 90.9 MeV. An evident interference pattern in the inelastic scattering has been observed for the first time in a strong Coulomb coupling system. (orig.)

  16. RNAi screen of DAF-16/FOXO target genes in C. elegans links pathogenesis and dauer formation.

    Directory of Open Access Journals (Sweden)

    Victor L Jensen

    2010-12-01

    Full Text Available The DAF-16/FOXO transcription factor is the major downstream output of the insulin/IGF1R signaling pathway controlling C. elegans dauer larva development and aging. To identify novel downstream genes affecting dauer formation, we used RNAi to screen candidate genes previously identified to be regulated by DAF-16. We used a sensitized genetic background [eri-1(mg366; sdf-9(m708], which enhances both RNAi efficiency and constitutive dauer formation (Daf-c. Among 513 RNAi clones screened, 21 displayed a synthetic Daf-c (SynDaf phenotype with sdf-9. One of these genes, srh-100, was previously identified to be SynDaf, but twenty have not previously been associated with dauer formation. Two of the latter genes, lys-1 and cpr-1, are known to participate in innate immunity and six more are predicted to do so, suggesting that the immune response may contribute to the dauer decision. Indeed, we show that two of these genes, lys-1 and clc-1, are required for normal resistance to Staphylococcus aureus. clc-1 is predicted to function in epithelial cohesion. Dauer formation exhibited by daf-8(m85, sdf-9(m708, and the wild-type N2 (at 27°C were all enhanced by exposure to pathogenic bacteria, while not enhanced in a daf-22(m130 background. We conclude that knockdown of the genes required for proper pathogen resistance increases pathogenic infection, leading to increased dauer formation in our screen. We propose that dauer larva formation is a behavioral response to pathogens mediated by increased dauer pheromone production.

  17. FY16 Strategic Themes White Paper.

    Energy Technology Data Exchange (ETDEWEB)

    Leland, Robert W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-03-01

    The Science and Technology (S&T) Division 1000 Strategic Plan includes the Themes, Goals, and Actions for FY16. S&T will continue to support the Labs Strategic plan, Mission Areas and Program Management Units by focusing on four strategic themes that align with the targeted needs of the Labs. The themes presented in this plan are Mission Engagement, Bold Outcomes, Collaborative Environment, and the Safety Imperative. Collectively they emphasize diverse, collaborative teams and a self-reliant culture of safety that will deliver on our promise of exceptional service in the national interest like never before. Mission Engagement focuses on increasing collaboration at all levels but with emphasis at the strategic level with mission efforts across the labs. Bold Outcomes seeks to increase the ability to take thoughtful risks with the goal of achieving transformative breakthroughs more frequently. Collaborative environment strives for a self-aware, collaborative working environment that bridges the many cultures of Sandia. Finally, Safety Imperative aims to minimize the risk of serious injury and to continuously strengthen the safety culture. Each of these themes is accompanied by a brief vision statement, several goals, and planned actions to support those goals throughout FY16 and leading into FY17.

  18. 40 CFR 74.61 - Monitoring plan.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Monitoring plan. 74.61 Section 74.61... OPT-INS Monitoring Emissions: Combustion Sources § 74.61 Monitoring plan. (a) Monitoring plan. The... monitoring plan that includes the information required in a monitoring plan under § 75.53 of this chapter...

  19. Countywide Evaluation of the Long-Term Family Self-Sufficiency Plan. Assessing the Utility of the LTFSS Plan Service Delivery and Planning Framework

    National Research Council Canada - National Science Library

    Davis, Lois

    2002-01-01

    ...) Plan on November 16,1999. The LTFSS Plan consists of 46 projects whose goal is to promote self-sufficiency among families that are participating in the California Work Opportunity and Responsibility to Kids Act of 1997 (CalWORKS...

  20. Assessing phosphatidylethanol (PEth) levels reflecting different drinking habits in comparison to the alcohol use disorders identification test - C (AUDIT-C).

    Science.gov (United States)

    Schröck, Alexandra; Wurst, Friedrich M; Thon, Natasha; Weinmann, Wolfgang

    2017-09-01

    In addition to monitoring problematic or harmful alcohol consumption, drinking experiments indicated the potential of phosphatidylethanols (PEth) in abstinence monitoring. To date, no profound evaluation of thresholds for the differentiation of abstinence from moderate drinking and for detection of excessive consumption based on PEth homologues exists. Investigations with a large group of healthy volunteers (n=300) were performed to establish PEth reference values reflecting different drinking habits. Blood samples were analyzed for PEth 16:0/18:1 and 16:0/18:2 by online-SPE-LC-MS/MS method. Results were compared to AUDIT-C questionnaires, to the amounts of alcohol consumed during the two-weeks prior to blood sampling, and were statistically evaluated. PEth concentrations were significantly correlated with self-reported alcohol consumption (r>0.69) and with AUDIT-C scores (r>0.65). 4.0% of 300 volunteers reported abstinence (AUDIT-C score: 0), no PEth was detectable in their blood. PEth 16:0/18:1 concentrations below the limit of detection of 10.0ng/mL match with abstinence and light drinking habits (≤10g pure alcohol/day). However, some volunteers classified as "excessive alcohol consumers" had negative PEth results. In the group of volunteers classified as "moderate drinkers" (AUDIT-C score: 1-3 (women) and 1-4 (men)), 95% of the test persons had PEth 16:0/18:1 ranging from not detected to 112ng/mL, and PEth 16:0/18:2 ranging from not detected to 67.0ng/mL. Combination of self-reported alcohol consumption and AUDIT-C score showed that negative PEth results match with abstinence or light drinking. Moderate alcohol consumption resulted in PEth 16:0/18:1 from 0 to 112ng/mL and for PEth 16:0/18:2 ranged from 0 to 67.0ng/mL. Higher PEth concentrations indicated excessive alcohol consumption. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Best management practices plan for environmental monitoring in Waste Area Grouping 6 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    International Nuclear Information System (INIS)

    1994-02-01

    This Best Management Practices (BMP) Plan has been developed as part of the environmental monitoring program at Waste Area Grouping (WAG) 6. The BMP Plan describes the requirements for personnel training, spill prevention and control, environmental compliance, and sediment/erosion control as they relate to environmental monitoring activities and installation of Monitoring Station 4 at WAG 6

  2. A Robust Planning Algorithm for Groups of Entities in Discrete Spaces

    Directory of Open Access Journals (Sweden)

    Igor Wojnicki

    2015-07-01

    Full Text Available Automated planning is a well-established field of artificial intelligence (AI, with applications in route finding, robotics and operational research, among others. The task of developing a plan is often solved by finding a path in a graph representing the search domain; a robust plan consists of numerous paths that can be chosen if the execution of the best (optimal one fails. While robust planning for a single entity is rather simple, development of a robust plan for multiple entities in a common environment can lead to combinatorial explosion. This paper proposes a novel hybrid approach, joining heuristic search and the wavefront algorithm to provide a plan featuring robustness in areas where it is needed, while maintaining a low level of computational complexity.

  3. The effect of aerobic versus strength-based training on high-sensitivity C-reactive protein in older adults.

    Science.gov (United States)

    Martins, Raul A; Neves, Ana P; Coelho-Silva, Manuel J; Veríssimo, Manuel T; Teixeira, Ana Maria

    2010-09-01

    Increased levels of inflammatory markers, namely, high-sensitive C-reactive protein (hs-CRP), have been associated with several chronic diseases including atherosclerosis, type 2 diabetes and hypertension. Forty-five women and men aged >64 years participated in the study and were randomly assigned to two exercise intervention groups and a non-exercising control group. The participants assigned to the exercising groups followed a 16-week exercise protocol based either on aerobic training (AT) or strength training (ST) followed by a further 16 weeks off-training period. The control group (C) remained sedentary throughout the study. Evaluation of body mass, BMI, waist circumference, aerobic endurance, lower-body strength, upper-body strength, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol and hs-CRP were performed at baseline, after 16 weeks (post-training for the exercise groups) and at 32 weeks (follow-up). Both, AT and ST groups significantly increased functional fitness at the end of the exercise programs when compared to baseline values. hs-CRP concentrations were maintained throughout the study for the C group, while decreasing 10% at 16 weeks and 51% at 32 weeks for the AT group. In the ST group the hs-CRP concentrations decreased by 11 and 39% at 16 and 32 weeks, respectively. Decreases in hs-CRP concentrations were statistically significant for the AT and ST groups at the 32-week evaluation when compared to baseline. Reduction in hs-CRP concentrations seemed to be associated with strength gains and adiposity loss.

  4. 30 CFR 784.16 - Reclamation plan: Siltation structures, impoundments, and refuse piles.

    Science.gov (United States)

    2010-07-01

    ... of being done after consideration of cost, logistics, and available technology. The fact that one... COAL EXPLORATION SYSTEMS UNDER REGULATORY PROGRAMS UNDERGROUND MINING PERMIT APPLICATIONS-MINIMUM..., and refuse piles. (a) General. Each application must include a general plan and a detailed design plan...

  5. Genetic characterization of enterovirus strains identified in Hand, Foot and Mouth Disease (HFMD): Emergence of B1c, C1 subgenotypes, E2 sublineage of CVA16, EV71 and CVA6 strains in India.

    Science.gov (United States)

    Ganorkar, Nital N; Patil, Pooja R; Tikute, Sanjay S; Gopalkrishna, Varanasi

    2017-10-01

    Hand, Foot and Mouth disease (HFMD) is a common childhood disease and caused due to Enterovirus-A (EV-A), EV-B and EV-C species worldwide. Cases of HFMD were reported from, Ahmedabad (Gujarat, 2012) and Pune (Maharashtra, 2013-2014) in India. The present study highlights the identification of EV strains (CVA16, CVA6, CVA4 and Echo12), characterization of subgenotypes of CVA16, CVA6 strains during 2012-14 and CVA16, CVA6, EV71 strains reported from the earlier study (2009-10) in HFMD cases from India. A total 158 clinical specimens collected from 64 HFMD cases (2012-2014) were included in the study. EV detection was carried out by 5'NCR based RT-PCR, molecular typing and subgenotyping was by VP1/2A junction or VP1, full VP1 gene amplification respectively followed by phylogenetic analysis. The present study reports 63.92% (101/158) EV positivity by RT-PCR. Ninety four of the 101 (93.06%) EV positive strains were amplified by VP1/2A junction or VP1 regions. Sequence analysis revealed the presence of CVA16 (61.7%), CVA6 (34.04%), CVA4 and Echo12 (4.3%). A total of 114 EV positive strains were genotyped using full and partial VP1 region. All CVA16 Indian strains (n=70) clustered with rarely reported B1c subgenotype, CVA6 (n=43) and EV71 (n=1) strains clustered with sub-lineage E2 and C1 subgenotypes respectively. In summary, the study reports genetic characterization of CVA16, CVA6, CVA4 and Echo12 strains in HFMD cases from India. Circulation of B1c subgenotype of CVA16, E2 sub-lineage of CVA6 and C1 subgenotype of EV 71 strains in HFMD cases were reported for the first time from India. This study helps to understand the genotype distribution, genetic diversity of EV strains associated with HFMD from Eastern, Western and Southern regions in India. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. ACCURATE LABORATORY WAVELENGTHS OF THE e 3 Σ-(ν' = 5) - X 1 Σ+(ν'' = 0) BAND OF 12C16O

    International Nuclear Information System (INIS)

    Dickenson, G. D.; Nortje, A. C.; Steenkamp, C. M.; Rohwer, E. G.; Du Plessis, A.

    2010-01-01

    The forbidden singlet-triplet transitions of carbon monoxide (CO) are important in the interpretation of vacuum ultraviolet interstellar absorption spectra and in particular for the measurement of large CO column densities. Twenty rovibronic lines of the e 3 Σ - (ν' = 5) - X 1 Σ + (ν'' = 0) band of 12 C 16 O for which laboratory wavelengths were previously unavailable were identified in laser-induced fluorescence excitation spectra. Wavelengths were assigned to five rovibronic transitions to an average accuracy of 0.0028 A. A further 15 lines could not be fully resolved and average wavelengths were measured for these groups of closely spaced lines. A wavelength difference of 0.011 ± 0.0028 A between the measured wavelengths and the calculated wavelengths in the atlas of Eidelsberg and Rostas demonstrates the need for more experimental data on CO.

  7. Accurate Laboratory Wavelengths of the e 3 Σ-(ν' = 5) - X 1 Σ+(ν'' = 0) Band of 12C16O

    Science.gov (United States)

    Dickenson, G. D.; Nortje, A. C.; Steenkamp, C. M.; Rohwer, E. G.; Du Plessis, A.

    2010-05-01

    The forbidden singlet-triplet transitions of carbon monoxide (CO) are important in the interpretation of vacuum ultraviolet interstellar absorption spectra and in particular for the measurement of large CO column densities. Twenty rovibronic lines of the e 3Σ-(ν' = 5) - X 1Σ+(ν'' = 0) band of 12 C 16O for which laboratory wavelengths were previously unavailable were identified in laser-induced fluorescence excitation spectra. Wavelengths were assigned to five rovibronic transitions to an average accuracy of 0.0028 Å. A further 15 lines could not be fully resolved and average wavelengths were measured for these groups of closely spaced lines. A wavelength difference of 0.011 ± 0.0028 Å between the measured wavelengths and the calculated wavelengths in the atlas of Eidelsberg & Rostas demonstrates the need for more experimental data on CO.

  8. New Horizons in C-F Activation by Main Group Electrophiles

    Energy Technology Data Exchange (ETDEWEB)

    Ozerov, Oleg V. [Texas A & M Univ., College Station, TX (United States). Dept. of Chemistry

    2016-02-13

    This technical report describes progress on the DOE sponsored project "New Horizons in C-F Activation by Main Group Electrophiles" during the period of 09/15/2010 – 08/31/2015. The main goal of this project was to develop improved catalysts for conversion of carbon-fluorine bonds in potentially harmful compounds. The approach involved combining of a highly reactive positively charged main-group compound with a highly unreactive negatively charged species (anions) as a way to access potent catalysts for carbon-fluorine bond activation. This report details progress made in improving synthetic pathways to a variety of new anions with improved properties and analysis of their potential in catalysis.

  9. 30 CFR 780.16 - Fish and wildlife information.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Fish and wildlife information. 780.16 Section... PLAN § 780.16 Fish and wildlife information. (a) Resource information. Each application shall include fish and wildlife resource information for the permit area and adjacent area. (1) The scope and level...

  10. 29 CFR 2560.502c-5 - Civil penalties under section 502(c)(5).

    Science.gov (United States)

    2010-07-01

    ... Act) that is not a group health plan, and that provides benefits consisting of medical care (within... section 502(c)(5) of the Act for each failure or refusal to file a completed report required to be filed...). (2) For purposes of this section, a failure or refusal to file the report required to be filed under...

  11. Well plugging and abandonment plan for Waste Area Grouping 6 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    International Nuclear Information System (INIS)

    Stansfield, R.G.; Huff, D.D.

    1992-06-01

    Site environmental characterization and remediation require data obtained from the installation and sampling of wells. When these wells are no longer needed or not producing reliable information, or are damaged and can act as conduits for contaminant migration, they should be identified and properly decommissioned. This is most important for wells of sufficient depth to create the potential for exchange of fluids between different hydrologic units. This plan presents the strategy and detailed approach for well plugging and abandonment (P ampersand A) at Waste Area Grouping 6 (WAG 6). An inventory of 768 wells, the total number known to have been installed in WAG 6 based on a combined review of data and direct field inventory, is provided in Appendix A. All wells that are no required for closure or postclosure surveillance of WAG 6 will be decommissioned. A listing of 69 existing WAG 6 wells that will be maintained for postclosure surveillance is provided in Appendix B, and their locations are shown in Fig. 1. Appendix C contains a list of all WAG 6 wells that will be decommissioned, although some may no longer exist. Their locations are shown in Fig. 2. It is likely that some new wells will be drilled as part of postclosure monitoring of Solid Waste Area 6 (SWSA), but they are beyond the scope of this report. It is intended that this plan provide a basis for developing contracts for cost and schedule determinations for the P ampersand A process

  12. Effect of the new C-12(alpha, gamma)O-16 rate on the chemical evolution of the solar neighborhood

    International Nuclear Information System (INIS)

    Matteucci, F.

    1986-01-01

    New models of chemical evolution of the solar neighborhood have been computed by taking into account the effect of the revised rate of the C-12(alpha, gamma)O-16 reaction on the chemical yields from massive stars, together with the yields from low- and intermediate-mass stars which also include those from Type I supernova explosions (C-deflagration in white dwarfs). In particular, the evolution of C-12, N-14, O-16, Ne-20, Mg-24, Si-28, and Fe-56 has been followed in detail, and their predicted solar absolute abundances as well as their relative ratios, both in the sun and in metal-poor stars, have been compared with the observed ones. It is concluded that a model with the new yields combined with a Salpeter initial mass function, an upper cutoff mass of 100 solar masses (the mass beyond which stars are not contributing to the galactic enrichment), and an upper limiting mass for intermediate-mass stars of the order of 5 solar masses, is in best agreement with the observations. 34 references

  13. Business Plan Competition open for CERN technologies

    CERN Multimedia

    TT Helpdesk

    2005-01-01

    Helping researchers turn great research into great business - that's the aim of the UK Research Council's Business Plan Competition. Every good business starts with two things: a good idea and a robust business plan. You supply the idea, and we'll give you the skills, knowledge and support you need to develop a first-rate business plan! This will be provided through expert trainers, coaches and mentors. Plus - the opportunity to win funds to help with the development of your business idea. The competition is open to researchers at CERN, promoted and supported by PPARC, together with the whole spectrum of academic research supported by the eight UK Research Councils - from the arts and biosciences, to environmental physical and social sciences to technology. Postgraduates, postdocs and academic staff who have a business idea arising from research and want to develop this further are encouraged to participate. Taking part is easy - just contact the TT group (TT Helpdesk) for details and support before 16 D...

  14. Creep and rupture behavior of weld-deposited Type 16-8-2 stainless steel at 5930C

    International Nuclear Information System (INIS)

    Ward, A.L.; Blackburn, L.D.

    1976-03-01

    The creep and rupture behavior of weld-deposited Type 16-8-2 stainless steel at 593 0 C was investigated over the time range from 3.6 x 10 4 s to 2.5 x 10 7 s. Equations relating stress to the time to rupture, the time to the onset of tertiary creep, and the time to produce a given creep strain were obtained. The experimental results indicate that the control of welding parameters (e.g. current, voltage and travel speed) within reasonable ranges can yield weld deposits with consistent time-dependent properties. Limited data suggest that high temperature (1065 0 C) post-weld annealing significantly alters only the flow curve for plastic deformation, while long-term thermal exposure at an intermediate temperature (565 0 C) produces only minor changes in either the plastic deformation or creep behavior of the weld materials

  15. 'Blocked area' of a citizens' action group in operating plan permit accoding to Mining Law

    Energy Technology Data Exchange (ETDEWEB)

    1982-05-26

    On the question as to whether a citizen's action group, organized in the form of a registered club, has the right to file suit as defined by paragraph 2 of sect. 42 of the rules of administrative courts, in case they bring forward that their right to the reforestation of an estate, ensured by easement, will be affected by a skeleton operating plan permit issued under the mining law. Since the protection of the recreational function of forests is a task the safeguarding of which is solely assigned to bodies of public administration, anyone who has a real right may not claim neighbourly protection under public law in so far. On the relationship between operating plan approval, procedures are according to mining laws and the licensing procedures concerning construction permits.

  16. Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition

    Science.gov (United States)

    Musante, Veronica; Li, Lu; Kanyo, Jean; Lam, Tukiet T; Colangelo, Christopher M; Cheng, Shuk Kei; Brody, A Harrison; Greengard, Paul; Le Novère, Nicolas; Nairn, Angus C

    2017-01-01

    ARPP-16, ARPP-19, and ENSA are inhibitors of protein phosphatase PP2A. ARPP-19 and ENSA phosphorylated by Greatwall kinase inhibit PP2A during mitosis. ARPP-16 is expressed in striatal neurons where basal phosphorylation by MAST3 kinase inhibits PP2A and regulates key components of striatal signaling. The ARPP-16/19 proteins were discovered as substrates for PKA, but the function of PKA phosphorylation is unknown. We find that phosphorylation by PKA or MAST3 mutually suppresses the ability of the other kinase to act on ARPP-16. Phosphorylation by PKA also acts to prevent inhibition of PP2A by ARPP-16 phosphorylated by MAST3. Moreover, PKA phosphorylates MAST3 at multiple sites resulting in its inhibition. Mathematical modeling highlights the role of these three regulatory interactions to create a switch-like response to cAMP. Together, the results suggest a complex antagonistic interplay between the control of ARPP-16 by MAST3 and PKA that creates a mechanism whereby cAMP mediates PP2A disinhibition. DOI: http://dx.doi.org/10.7554/eLife.24998.001 PMID:28613156

  17. PREVALENCE OF OVERWEIGHT, OBESITY, PAEDIATRIC METABOLIC SYNDROME AND ASSOCIATED RISK FACTORS AMONG CHILDREN IN THE AGE GROUP OF 10-16 YEARS IN PRIVATE SCHOOLS OF SHIMLA CITY

    Directory of Open Access Journals (Sweden)

    Anmol Gupta

    2017-07-01

    Full Text Available BACKGROUND Paediatric obesity is a complex and growing global problem which is escalating much more rapidly in developing countries like India and considered an important predecessor to NCD multi-morbidity due to changing life style as a result of rapid urbanisation and mechanisation. The aim of this study was to estimate the prevalence of overweight, obesity, paediatric metabolic syndrome and associated risk factors among children in the age group of 10-16 years in private schools of Shimla city. MATERIALS AND METHODS At total of 2100 adolescents attending school (aged 10-16 years participated in this cross-sectional study. All the anthropometric, clinical and biochemical assessment was done after proper consent. Prevalence of overweight and obesity was assessed by using IOTF guidelines and the metabolic syndrome was determined by the Paediatric International Diabetic Federation definition modified for age group. RESULTS The prevalence of overweight, obesity and paediatric metabolic syndrome was 14.5%, 4.1% & 4.3% respectively. In the groups with PMS, hypertension, waist circumference, and TG were significantly higher, and HDL-C was significantly lower. Significant difference was observed in gender, physical activity level, metabolic equivalent, consumption of junk food & time spent on TV in the distribution of overweight, obesity and metabolic syndrome. CONCLUSION Our study highlights the possible role of change in the dietary pattern and physical activity pattern in the development of obesity and metabolic syndrome in early stage of life. Collective efforts of parents and schools are required to institute early preventive measures to reduce progression towards obesity and its future complications.

  18. Dicty_cDB: Contig-U14913-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FLD1_53_G01.g1_A029 Root flooded Pinus taeda cDNA... 50 0.16 1 ( CO165241 ) FLD1_53_G01.b1_A029 Root flooded... Pinus taeda cDNA... 50 0.16 1 ( CO163000 ) FLD1_38_G07.g1_A029 Root flooded Pinus taeda cDNA... 50 0.16 1 (... CO162917 ) FLD1_38_G07.b1_A029 Root flooded Pinus taeda cDNA... 50 0.16 1 ( CO15...9866 ) FLD1_16_B12.g1_A029 Root flooded Pinus taeda cDNA... 50 0.16 1 ( CO158395 ) FLD1_6_D06.g1_A029 Root flood

  19. 16O resonances near 4α threshold through 12C (6Li,d ) reaction

    Science.gov (United States)

    Rodrigues, M. R. D.; Borello-Lewin, T.; Miyake, H.; Horodynski-Matsushigue, L. B.; Duarte, J. L. M.; Rodrigues, C. L.; de Faria, P. Neto; Cunsolo, A.; Cappuzzello, F.; Foti, A.; Agodi, C.; Cavallaro, M.; di Napoli, M.; Ukita, G. M.

    2014-11-01

    Several narrow alpha resonant 16O states were detected through the 12C (6Li,d ) reaction, in the range of 13.5 to 17.5 MeV of excitation energy. The reaction was measured at a bombarding energy of 25.5 MeV employing the São Paulo Pelletron-Enge-Spectrograph facility and the nuclear emulsion technique. Experimental angular distributions associated with natural parity quasi-bound states around the 4α threshold are presented and compared to DWBA predictions. The upper limit for the resonance widths obtained is near the energy resolution (15 keV).

  20. 16O resonances near 4α threshold through 12C(6Li,d) reaction

    International Nuclear Information System (INIS)

    Rodrigues, M. R. D.; Borello-Lewin, T.; Miyake, H.; Horodynski-Matsushigue, L. B.; Duarte, J. L. M.; Rodrigues, C. L.; Faria, P. Neto de; Cunsolo, A.; Cappuzzello, F.; Foti, A.; Agodi, C.; Cavallaro, M.; Napoli, M. di; Ukita, G. M.

    2014-01-01

    Several narrow alpha resonant 16 O states were detected through the 12 C( 6 Li,d) reaction, in the range of 13.5 to 17.5 MeV of excitation energy. The reaction was measured at a bombarding energy of 25.5 MeV employing the São Paulo Pelletron-Enge-Spectrograph facility and the nuclear emulsion technique. Experimental angular distributions associated with natural parity quasi-bound states around the 4α threshold are presented and compared to DWBA predictions. The upper limit for the resonance widths obtained is near the energy resolution (15 keV)

  1. TaPP2C1, a Group F2 Protein Phosphatase 2C Gene, Confers Resistance to Salt Stress in Transgenic Tobacco.

    Directory of Open Access Journals (Sweden)

    Wei Hu

    Full Text Available Group A protein phosphatases 2Cs (PP2Cs are essential components of abscisic acid (ABA signaling in Arabidopsis; however, the function of group F2 subfamily PP2Cs is currently less known. In this study, TaPP2C1 which belongs to group F2 was isolated and characterized from wheat. Expression of the TaPP2C1-GFP fusion protein suggested its ubiquitous localization within a cell. TaPP2C1 expression was downregulated by abscisic acid (ABA and NaCl treatments, but upregulated by H2O2 treatment. Overexpression of TaPP2C1 in tobacco resulted in reduced ABA sensitivity and increased salt resistance of transgenic seedlings. Additionally, physiological analyses showed that improved resistance to salt stress conferred by TaPP2C1 is due to the reduced reactive oxygen species (ROS accumulation, the improved antioxidant system, and the increased transcription of genes in the ABA-independent pathway. Finally, transgenic tobacco showed increased resistance to oxidative stress by maintaining a more effective antioxidant system. Taken together, these results demonstrated that TaPP2C1 negatively regulates ABA signaling, but positively regulates salt resistance. TaPP2C1 confers salt resistance through activating the antioxidant system and ABA-independent gene transcription process.

  2. Usefulness of p16ink4a, ProEX C, and Ki-67 for the diagnosis of glandular dysplasia and adenocarcinoma of the cervix uteri.

    Science.gov (United States)

    Negri, Giovanni; Bellisano, Giulia; Carico, Elisabetta; Faa, Gavino; Kasal, Armin; Antoniazzi, Sonia; Egarter-Vigl, Eduard; Piccin, Andrea; Dalla Palma, Paolo; Vittadello, Fabio

    2011-07-01

    Although the diagnostic criteria of in-situ and invasive adenocarcinomas of the cervix uteri are well established, the differentiation from benign mimics may be difficult and the morphologic features of the precursors of endocervical adenocarcinoma are still debated. In this study, we evaluated the usefulness of p16ink4a (p16), ProEX C, and Ki-67 for the diagnosis of endocervical adenocarcinoma and its precursors. Immunohistochemistry with p16, ProEX C, and Ki-67 was performed in 82 glandular lesions including 15 invasive adenocarcinomas, 29 adenocarcinomas in situ (AIS), 22 non-neoplastic samples, and 16 cases of glandular dysplasia (GD), which showed significant nuclear abnormalities but did not meet the diagnostic criteria for AIS. The immunohistochemical expression pattern was scored according to the percentage of the stained cells (0, 1+, 2+, and 3+ when 0% to 5%, 6% to 25%, 26% to 50%, and more than 50% of the cells were stained, respectively) and was evaluated for each antibody. p16 was at least focally expressed (1+ or more) in 14 of 15 invasive adenocarcinomas, in all AIS and in 7 negative samples. ProEX C and Ki-67 both scored 1+ or more in all adenocarcinomas and AIS and in 8 and 6 negative samples, respectively. Of the GD 15, 14, and 15 expressed p16, ProEX C, and Ki-67, respectively. The score differences between neoplastic and non-neoplastic samples were highly significant for each marker (Pcervix uteri and may also improve the diagnostic accuracy of endocervical GD. In particularly problematic cases, the combination of p16 and a proliferation marker can provide additional help for the interpretation of these lesions.

  3. Efficacy of a meal replacement diet plan compared to a food-based diet plan after a period of weight loss and weight maintenance: a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Hutchisen Tammy

    2010-03-01

    Full Text Available Abstract Background Obesity has reached epidemic proportions in the United States. It is implicated in the development of a variety of chronic disease states and is associated with increased levels of inflammation and oxidative stress. The objective of this study is to examine the effect of Medifast's meal replacement program (MD on body weight, body composition, and biomarkers of inflammation and oxidative stress among obese individuals following a period of weight loss and weight maintenance compared to a an isocaloric, food-based diet (FB. Methods This 40-week randomized, controlled clinical trial included 90 obese adults with a body mass index (BMI between 30 and 50 kg/m2, randomly assigned to one of two weight loss programs for 16 weeks and then followed for a 24-week period of weight maintenance. The dietary interventions consisted of Medifast's meal replacement program for weight loss and weight maintenance, or a self-selected, isocaloric, food-based meal plan. Results Weight loss at 16 weeks was significantly better in the Medifast group (MD versus the food-based group (FB (12.3% vs. 6.9%, and while significantly more weight was regained during weight maintenance on MD versus FB, overall greater weight loss was achieved on MD versus FB. Significantly more of the MD participants lost ≥ 5% of their initial weight at week 16 (93% vs. 55% and week 40 (62% vs. 30%. There was no difference in satiety observed between the two groups during the weight loss phase. Significant improvements in body composition were also observed in MD participants compared to FB at week 16 and week 40. At week 40, both groups experienced improvements in biochemical outcomes and other clinical indicators. Conclusions Our data suggest that the meal replacement diet plan evaluated was an effective strategy for producing robust initial weight loss and for achieving improvements in a number of health-related parameters during weight maintenance, including inflammation

  4. Construction of a bi parametric analysis system. Application to the study of the decay of the 16.11 MeV level of {sup 12}C; Realisation d'un ensemble d'analyse biparametrique. Application a l'etude de la desintegration du niveau de 16,11 MeV du {sup 12}C

    Energy Technology Data Exchange (ETDEWEB)

    Engelhardt, H D [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1966-11-15

    A baroreceptor analysis system has been assembled to measure {alpha}-{alpha} spectra in coincidence (resolution 2 {tau} = 10 ns). The correlations in energy and angle of the {alpha}-particles emitted from the reaction {sup 11}B(p,{alpha}) have been studied using 163 keV protons produced by a Van-de-Graaff accelerator. Evidence has been obtained for the sequential decay of {sup 12}C{sup *} (16.11 MeV) via the 0{sup +} and 2{sup +} states of {sup 8}Be. Contributions from the {sup 8}Be{sup *}(4{sup +}) level or from the simultaneous break-up of {sup 12}C{sup *} (16.11 MeV) into three {alpha}-particles cannot be excluded. (author) [French] On a mis au point un dispositif d'analyse biparametrique de spectres {alpha}-{alpha} en coincidences (resolution 2 {tau} = 10 ns). On a etudie, a l'aide de ce dispositif et d'un accelerateur Van de Graaff la correlation d'energie et angulaire entre les particules a de la reaction {sup 11}B(p,{alpha}) a une energie de protons E{sub p} = 163 keV. On a mis en evidence la desintegration sequentielle du {sup 12}C{sup *} (16.11 MeV) par les etats (0{sup +} et 2{sup +}) du {sup 8}Be. La contribution d'un niveau (4{sup +}) du {sup 8}Be{sup *} ou d'une desintegration simultanee du {sup 12}C{sup *} (16,11 MeV) en 3 {alpha} ne peut pas etre exclue. (auteur)

  5. Aryliminopropadienone-C-Amidoketenimine- Amidinoketene-2-Aminoquinolone Cascades and the Ynamine-Isocyanate Reaction.

    Science.gov (United States)

    Wentrup, Curt; Rao, V. V. Ramana; Frank, Wilhelm; Fulloon, Belinda E.; Moloney, Daniel W. J.; Mosandl, Thomas

    1999-05-14

    Imidoylketenes 11 and oxoketenimines 12 are generated by flash vacuum thermolysis of Meldrum's acid derivatives 9, pyrrolediones 17 and 18, and triazole 19 and are observed by IR spectroscopy. Ketenimine-3-carboxylic acid esters 12a are isolable at room temperature. Ketenes 11 and ketenimines 12 undergo rapid interconversion in the gas phase, and the ketenes cyclize to 4-quinolones 13. When using an amine leaving group in Meldrum's acid derivatives 9c, the major reaction products are aryliminopropadienones, ArN=C=C=C=O (15). The latter react with 1 equiv of nucleophile to produce ketenimines 12 and with 2 equiv to afford malonic acid imide derivatives 16. N-Arylketenimine-C-carboxamides 12c cyclize to quinolones 13c via the transient amidinoketenes 11c at temperatures of 25-40 degrees C. This implies rapid interconversion of ketenes and ketenimines by a 1,3-shift of the dimethylamino group, even at room temperature. This interconversion explains previously poorly understood outcomes of the ynamine-isocyanate reaction. The solvent dependence of the tautomerism of 4-quinolones/4-quinolinols is discussed. Rotational barriers of NMe(2) groups in amidoketenimines 12c and malonioc amides and amidines 16 (24) are reported.

  6. Quantization and Superselection Sectors I:. Transformation Group C*-ALGEBRAS

    Science.gov (United States)

    Landsman, N. P.

    Quantization is defined as the act of assigning an appropriate C*-algebra { A} to a given configuration space Q, along with a prescription mapping self-adjoint elements of { A} into physically interpretable observables. This procedure is adopted to solve the problem of quantizing a particle moving on a homogeneous locally compact configuration space Q=G/H. Here { A} is chosen to be the transformation group C*-algebra corresponding to the canonical action of G on Q. The structure of these algebras and their representations are examined in some detail. Inequivalent quantizations are identified with inequivalent irreducible representations of the C*-algebra corresponding to the system, hence with its superselection sectors. Introducing the concept of a pre-Hamiltonian, we construct a large class of G-invariant time-evolutions on these algebras, and find the Hamiltonians implementing these time-evolutions in each irreducible representation of { A}. “Topological” terms in the Hamiltonian (or the corresponding action) turn out to be representation-dependent, and are automatically induced by the quantization procedure. Known “topological” charge quantization or periodicity conditions are then identically satisfied as a consequence of the representation theory of { A}.

  7. 105-C Reactor interim safe storage project technology integration plan

    International Nuclear Information System (INIS)

    Pulsford, S.K.

    1997-01-01

    The 105-C Reactor Interim Safe Storage Project Technology Integration Plan involves the decontamination, dismantlement, and interim safe storage of a surplus production reactor. A major goal is to identify and demonstrate new and innovative D and D technologies that will reduce costs, shorten schedules, enhance safety, and have the potential for general use across the RL complex. Innovative technologies are to be demonstrated in the following areas: Characterization; Decontamination; Waste Disposition; Dismantlement, Segmentation, and Demolition; Facility Stabilization; and Health and Safety. The evaluation and ranking of innovative technologies has been completed. Demonstrations will be selected from the ranked technologies according to priority. The contractor team members will review and evaluate the demonstration performances and make final recommendations to DOE

  8. Waste management plan for the remedial investigation of Waste Area Grouping 2 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    International Nuclear Information System (INIS)

    Baron, L.A.

    1994-10-01

    This Project Waste Management Plan defines the criteria and methods to be used for managing waste generated during activities associated with Waste Area Grouping 2 at Oak Ridge National Laboratory. The waste management strategy is based on the generation and management of waste on a systematic basis using the most appropriate combination of waste reduction, segregation, treatment, storage, and disposal practices while protecting the environment and human health, maintaining as low as reasonably achievable limits. This plan contains provisions for safely and effectively managing soils and sediments, sampling water, decontamination fluids, and disposable personal protective equipment consistent with the US Environmental Protection Agency guidance. This plan will be used in conjunction with the ORNL ER Program Waste Management Plan

  9. Automated Volumetric Modulated Arc Therapy Treatment Planning for Stage III Lung Cancer: How Does It Compare With Intensity-Modulated Radio Therapy?

    Energy Technology Data Exchange (ETDEWEB)

    Quan, Enzhuo M. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Chang, Joe Y.; Liao Zhongxing [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Xia Tingyi [Department of Radiation Oncology, Beijing 301 Hospital, Beijing (China); Yuan Zhiyong [Department of Radiation Oncology, Tianjin Medical University Cancer Hospital and Institute, Tianjin (China); Liu Hui [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Oncology, Zhongshan University Hospital, Guangzhou (China); Li, Xiaoqiang; Wages, Cody A.; Mohan, Radhe [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhang Xiaodong, E-mail: xizhang@mdanderson.org [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2012-09-01

    Purpose: To compare the quality of volumetric modulated arc therapy (VMAT) or intensity-modulated radiation therapy (IMRT) plans generated by an automated inverse planning system with that of dosimetrist-generated IMRT treatment plans for patients with stage III lung cancer. Methods and Materials: Two groups of 8 patients with stage III lung cancer were randomly selected. For group 1, the dosimetrists spent their best effort in designing IMRT plans to compete with the automated inverse planning system (mdaccAutoPlan); for group 2, the dosimetrists were not in competition and spent their regular effort. Five experienced radiation oncologists independently blind-reviewed and ranked the three plans for each patient: a rank of 1 was the best and 3 was the worst. Dosimetric measures were also performed to quantitatively evaluate the three types of plans. Results: Blind rankings from different oncologists were generally consistent. For group 1, the auto-VMAT, auto-IMRT, and manual IMRT plans received average ranks of 1.6, 2.13, and 2.18, respectively. The auto-VMAT plans in group 1 had 10% higher planning tumor volume (PTV) conformality and 24% lower esophagus V70 (the volume receiving 70 Gy or more) than the manual IMRT plans; they also resulted in more than 20% higher complication-free tumor control probability (P+) than either type of IMRT plans. The auto- and manual IMRT plans in this group yielded generally comparable dosimetric measures. For group 2, the auto-VMAT, auto-IMRT, and manual IMRT plans received average ranks of 1.55, 1.75, and 2.75, respectively. Compared to the manual IMRT plans in this group, the auto-VMAT plans and auto-IMRT plans showed, respectively, 17% and 14% higher PTV dose conformality, 8% and 17% lower mean lung dose, 17% and 26% lower mean heart dose, and 36% and 23% higher P+. Conclusions: mdaccAutoPlan is capable of generating high-quality VMAT and IMRT treatment plans for stage III lung cancer. Manual IMRT plans could achieve quality

  10. Automated Volumetric Modulated Arc Therapy Treatment Planning for Stage III Lung Cancer: How Does It Compare With Intensity-Modulated Radio Therapy?

    International Nuclear Information System (INIS)

    Quan, Enzhuo M.; Chang, Joe Y.; Liao Zhongxing; Xia Tingyi; Yuan Zhiyong; Liu Hui; Li, Xiaoqiang; Wages, Cody A.; Mohan, Radhe; Zhang Xiaodong

    2012-01-01

    Purpose: To compare the quality of volumetric modulated arc therapy (VMAT) or intensity-modulated radiation therapy (IMRT) plans generated by an automated inverse planning system with that of dosimetrist-generated IMRT treatment plans for patients with stage III lung cancer. Methods and Materials: Two groups of 8 patients with stage III lung cancer were randomly selected. For group 1, the dosimetrists spent their best effort in designing IMRT plans to compete with the automated inverse planning system (mdaccAutoPlan); for group 2, the dosimetrists were not in competition and spent their regular effort. Five experienced radiation oncologists independently blind-reviewed and ranked the three plans for each patient: a rank of 1 was the best and 3 was the worst. Dosimetric measures were also performed to quantitatively evaluate the three types of plans. Results: Blind rankings from different oncologists were generally consistent. For group 1, the auto-VMAT, auto-IMRT, and manual IMRT plans received average ranks of 1.6, 2.13, and 2.18, respectively. The auto-VMAT plans in group 1 had 10% higher planning tumor volume (PTV) conformality and 24% lower esophagus V70 (the volume receiving 70 Gy or more) than the manual IMRT plans; they also resulted in more than 20% higher complication-free tumor control probability (P+) than either type of IMRT plans. The auto- and manual IMRT plans in this group yielded generally comparable dosimetric measures. For group 2, the auto-VMAT, auto-IMRT, and manual IMRT plans received average ranks of 1.55, 1.75, and 2.75, respectively. Compared to the manual IMRT plans in this group, the auto-VMAT plans and auto-IMRT plans showed, respectively, 17% and 14% higher PTV dose conformality, 8% and 17% lower mean lung dose, 17% and 26% lower mean heart dose, and 36% and 23% higher P+. Conclusions: mdaccAutoPlan is capable of generating high-quality VMAT and IMRT treatment plans for stage III lung cancer. Manual IMRT plans could achieve quality

  11. Pathogenicity of Virulent Species of Group C Streptococci in Human

    Directory of Open Access Journals (Sweden)

    Marta Kłos

    2017-01-01

    Full Text Available Group C streptococci (GCS are livestock pathogens and they often cause zoonotic diseases in humans. They are Gram-positive, in mostly β-hemolytic and facultative anaerobes. Because of their close evolutionary kinship with group A streptococci (GAS, GCS share many common virulence factors with GAS and cause a similar range of diseases. Due to the exchange of genetic material with GAS, GCS belong to bacteria that are difficult to be distinguished from group A streptococci; GCS are often treated in microbiological diagnostics as contamination of the culture. This report focuses mainly on the pathogenicity of virulent species of GCS and their association with human diseases. The condition that is most frequently quoted is pharyngitis. In this paper, the virulence factors have also been mentioned and an interesting link has been made between GCS and the pathogenesis of rheumatic diseases among the native people of India and Aboriginal populations.

  12. 40 CFR 469.16 - Pretreatment standards for existing sources (PSES).

    Science.gov (United States)

    2010-07-01

    ... sources (PSES). 469.16 Section 469.16 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ELECTRICAL AND ELECTRONIC COMPONENTS POINT SOURCE CATEGORY Semiconductor... implement the solvent management plan approved by the control authority. ...

  13. Visual detection of human enterovirus 71 subgenotype C4 and Coxsackievirus A16 by reverse transcription loop-mediated isothermal amplification with the hydroxynaphthol blue dye.

    Science.gov (United States)

    Nie, Kai; Zhang, Yong; Luo, Le; Yang, Meng-Jie; Hu, Xiu-Mei; Wang, Miao; Zhu, Shuang-Li; Han, Feng; Xu, Wen-Bo; Ma, Xue-Jun

    2011-08-01

    A sensitive reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay was developed for rapid visual detection of human enterovirus 71 subgenotype C4 (EV71-C4) and Coxsackievirus A16 (CVA16) infection, respectively. The reaction was performed in one step in a single tube at 65°C for 60 min with the addition of the hydroxynaphthol blue (HNB) dye prior to amplification. The detection limits of the RT-LAMP assay were 0.33 and 1.58 of a 50% tissue culture infective dose (TCID(50)) per reaction based on 10-fold dilutions of a titrated EV71 or CVA16 strain, respectively. No cross-reaction was observed with Coxsackievirus A (CVA) viruses (CVA2, 4, 5, 7, 9, 10, 14, and 24), Coxsackievirus B (CVB) viruses (CVB1,2,3,4, and 5) or ECHO viruses (ECHO3, 6, 11, and 19). The assay was further evaluated with 47 clinical stool specimens diagnosed previously with EV71, CVA16 or other human enterovirus infections. Virus isolates from stool samples were confirmed by virus neutralization testing and sequencing. RT-LAMP with HNB dye was demonstrated to be a sensitive and cost-effective assay for rapid visual detection of human EV71-C4 and CVA16. Copyright © 2011 Elsevier B.V. All rights reserved.

  14. SU-F-T-604: Dosimetric Evaluation of Intracranial Stereotactic Radiotherapy Plans On a LINAC

    Energy Technology Data Exchange (ETDEWEB)

    Sheth, N; Tabibian, A; Rose, J; Alvelo, M; Perel, C; Laiken, K; Kim, A [Bayonne Medical Center, Bayonne, NJ (United States)

    2016-06-15

    Purpose: To evaluate the dosimetry of cranial stereotactic radiotherapy (SRT) plans of varying techniques on linac that meets appropriate TG-142 tolerances using 1 cm leaf width multileaf collimator (MLC). Methods: Seventeen spherical targets were generated in the center of a head phantom with diameters ranging 8 mm to 40 mm. SRT plans used 100° non-coplanar arcs and 5 couch angles with 35° spacing. The field size was target plus 1 mm margin. Four plans were created for each target: symmetrical jaws blocking for 5 arcs with 0° collimator (J1C), symmetrical jaws blocking with 5 clockwise arcs with 0° collimator and 5 counter-clockwise arcs with 45° collimator (J2C), MLC blocking for 5 dynamic conformal arcs with 0° collimator (M1C), and MLC blocking for 5 clockwise dynamic conformal arcs with 0° collimators and 5 counter-clockwise dynamic conformal arcs with 45° collimator (M2C).Conformity was evaluated using a ratio of Rx to target volume (PITV). Heterogeneity was determined using a ratio of maximum dose to Rx dose. Falloff was scored using CGIg: difference of effective radii of spheres equal to half and full Rx volumes. Results: All plans met RTOG SRS criteria for conformity and heterogeneity. The mean PITV was 1.52±0.07, 1.49±0.08, 1.39±0.05, and 1.37±0.04 for J1C, J2C, M1C, and M2C plans respectively. The mean CGIg was 75.35±15.79, 74.19±16.66, 77.14±15.12, and 76.28±15.78 for J1C, J2C, M1C, and M2C plans respectively. The mean MDPD was 1.25±0.00 for all techniques. Conclusion: Clinically acceptable SRT plans for spherical targets were created on a linac with 1 cm MLC. Adding two collimator angles and MLC to arcs each improved conformity. The MLC improved the dose falloff while two collimator angles degraded it. This technique can expand the availability of SRT to patients especially to those who cannot travel to a facility with a dedicated stereotactic radiosurgery machine.

  15. SU-F-T-604: Dosimetric Evaluation of Intracranial Stereotactic Radiotherapy Plans On a LINAC

    International Nuclear Information System (INIS)

    Sheth, N; Tabibian, A; Rose, J; Alvelo, M; Perel, C; Laiken, K; Kim, A

    2016-01-01

    Purpose: To evaluate the dosimetry of cranial stereotactic radiotherapy (SRT) plans of varying techniques on linac that meets appropriate TG-142 tolerances using 1 cm leaf width multileaf collimator (MLC). Methods: Seventeen spherical targets were generated in the center of a head phantom with diameters ranging 8 mm to 40 mm. SRT plans used 100° non-coplanar arcs and 5 couch angles with 35° spacing. The field size was target plus 1 mm margin. Four plans were created for each target: symmetrical jaws blocking for 5 arcs with 0° collimator (J1C), symmetrical jaws blocking with 5 clockwise arcs with 0° collimator and 5 counter-clockwise arcs with 45° collimator (J2C), MLC blocking for 5 dynamic conformal arcs with 0° collimator (M1C), and MLC blocking for 5 clockwise dynamic conformal arcs with 0° collimators and 5 counter-clockwise dynamic conformal arcs with 45° collimator (M2C).Conformity was evaluated using a ratio of Rx to target volume (PITV). Heterogeneity was determined using a ratio of maximum dose to Rx dose. Falloff was scored using CGIg: difference of effective radii of spheres equal to half and full Rx volumes. Results: All plans met RTOG SRS criteria for conformity and heterogeneity. The mean PITV was 1.52±0.07, 1.49±0.08, 1.39±0.05, and 1.37±0.04 for J1C, J2C, M1C, and M2C plans respectively. The mean CGIg was 75.35±15.79, 74.19±16.66, 77.14±15.12, and 76.28±15.78 for J1C, J2C, M1C, and M2C plans respectively. The mean MDPD was 1.25±0.00 for all techniques. Conclusion: Clinically acceptable SRT plans for spherical targets were created on a linac with 1 cm MLC. Adding two collimator angles and MLC to arcs each improved conformity. The MLC improved the dose falloff while two collimator angles degraded it. This technique can expand the availability of SRT to patients especially to those who cannot travel to a facility with a dedicated stereotactic radiosurgery machine.

  16. Dental affinities of the C-group inhabitants of Hierakonpolis, Egypt: Nubian, Egyptian, or both?

    Science.gov (United States)

    Irish, J D; Friedman, R

    2010-04-01

    By c. 2050 BC a small community of C-Group Nubians was present deep within Egyptian territory at the city of Hierakonpolis. Their descendants stayed for the next 400 years. Today, the site of Hierakonpolis, 113 km north of Aswan, is known for its Egyptian deposits; however, it also contains a C-Group cemetery, which documents the northernmost occurrence of this culture. Sixty skeletons were excavated. Tombs feature Nubian architecture and goods, including leather garments, although the use of Egyptian mortuary practices and artifacts increased through time. Dates range from the early 11th Dynasty into the Second Intermediate period. During this time the Egyptian empire occupied Lower Nubia, and their state ideology vilified Nubians. Yet, at least in death, the C-Group inhabitants of Hierakonpolis proudly displayed their cultural heritage. Beyond discerning the reason(s) for their presence at the site (e.g., mercenaries, leather-workers, entertainers?), the focus of this report is to estimate their biological affinity. Were they akin to other Nubians, Egyptians, or both? And, was increasing 'Egyptianization' evident in the mortuary ritual accompanied by concomitant genetic influence? To address these queries, up to 36 dental morphological traits in the recovered individuals were compared to those in 26 regional comparative samples. The most influential traits were identified and phenetic affinities were calculated using the mean measure of divergence and other multivariate analyses. Assuming phenetic similarity provides an estimate of genetic relatedness, these affinities suggest the individuals comprising the C-Group sample were, and remained Nubian during their tenure at Hierakonpolis. Copyright 2010 Elsevier GmbH. All rights reserved.

  17. Public Participation Plan for Waste Area Group 7 Operable Unit 7-13/14 at the Idaho National Laboratory Site

    International Nuclear Information System (INIS)

    B. G. Meagher

    2007-01-01

    This Public Participation Plan outlines activities being planned to: (1) brief the public on results of the remedial investigation and feasibility study, (2) discuss the proposed plan for remediation of Operable Unit 7-13/14 with the public, and (3) encourage public participation in the decision-making process. Operable Unit 7-13/14 is the Comprehensive Remedial Investigation/Feasibility Study for Waste Area Group 7. Analysis focuses on the Subsurface Disposal Area (SDA) within the Radioactive Waste Management Complex at the Idaho National Laboratory (Site). This plan, a supplement to the Idaho National Laboratory Community Relations Plan (DOE-ID 2004), will be updated as necessary. The U.S. Department of Energy (DOE), Idaho Department of Environmental Quality (DEQ), and U.S. Environmental Protection Agency (EPA) will participate in the public involvement activities outlined in this plan. Collectively, DOE, DEQ, and EPA are referred to as the Agencies. Because history has shown that implementing the minimum required public involvement activities is not sufficient for high-visibility cleanup projects, this plan outlines additional opportunities the Agencies are providing to ensure that the public's information needs are met and that the Agencies can use the public's input for decisions regarding remediation activities

  18. 45 CFR 63.16 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... OFFICE OF THE ASSISTANT SECRETARY FOR PLANNING AND EVALUATION Financial Provisions § 63.16 Scope of subpart. This subpart sets forth supplemental financial provisions which apply to all grants awarded by...

  19. 40 CFR 16.2 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Definitions. 16.2 Section 16.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL IMPLEMENTATION OF PRIVACY ACT OF 1974 § 16... records have the same meanings as specified in 5 U.S.C. 552a. (b) EPA means the Environmental Protection...

  20. Cloning and analysis of the mouse Fanconi anemia group a cDNA and an overlapping penta zinc finger cDNA

    NARCIS (Netherlands)

    Wong, JCY; Alon, N; Norga, K; Kruyt, FAE; Youssoufian, H; Buchwald, M

    2000-01-01

    Despite the cloning of four disease-associated genes for Fanconi anemia (FA), the molecular pathogenesis of FA remains largely unknown. To study FA complementation group A using the mouse as a mode I system, we cloned and characterized the mouse homolog of the human FANCA cDNA, The mouse cDNA

  1. Synthesis of the C1-C28 Portion of Spongistatin 1 (Altohyrtin A).

    Science.gov (United States)

    Claffey, Michelle M.; Hayes, Christopher J.; Heathcock, Clayton H.

    1999-10-29

    A synthetic approach was developed to the C1-C28 subunit of spongistatin 1 (altohyrtin A, 65). The key step was the coupling of the AB and CD spiroketal moieties via an anti-aldol reaction of aldehyde 62 and ethyl ketone 57. The development of a method for the construction of the AB spiroketal fragment is described and included the desymmetrization of C(2)-symmetric diketone 10 and the differentiation of the two primary alcohols of 16. Further elaboration of this advanced intermediate to the desired aldehyde 62 included an Evans' syn-aldol reaction and Tebbe olefination. The synthesis of the CD spiroketal fragment 56 involved the ketalization of a triol-dione, generated in situ by deprotection of 45, to provide a favorable ratio (6-7:1) of spiroketal isomers 46 and 47, respectively. The overall protecting group strategy, involving many selective manipulations of silyl protecting groups, was successfully developed to provide the desired C1-C28 subunit of spongistatin 1 (altohyrtin A) (65).

  2. Meteorological monitoring sampling and analysis plan for the environmental monitoring plan at Waste Area Grouping 6, Oak Ridge National Laboratory, Oak Ridge, Tennessee

    International Nuclear Information System (INIS)

    1995-09-01

    This Sampling and Analysis Plan addresses meteorological monitoring activities that wall be conducted in support of the Environmental Monitoring Plan for Waste Area Grouping (WAG) 6. WAG 6 is a shallow-burial land disposal facility for low-level radioactive waste at the Oak Ridge National Laboratory, a research facility owned by the US Department of Energy and managed by Lockheed Martin Energy Systems, Inc. Meteorological monitoring of various climatological parameters (e.g., temperature, wind speed, humidity) will be collected by instruments installed at WAG 6. Data will be recorded electronically at frequencies varying from 5-min intervals to 1-h intervals, dependent upon parameter. The data will be downloaded every 2 weeks, evaluated, compressed, and uploaded into a WAG 6 data base for subsequent use. The meteorological data will be used in water balance calculations in support of the WAG 6 hydrogeological model

  3. Stereochemistry of 16a-Hydroxyfriedelin and 3-Oxo-16-methylfriedel-16-ene Established by 2D NMR Spectroscopy

    Directory of Open Access Journals (Sweden)

    Vagner Fernandes Knupp

    2009-02-01

    Full Text Available Friedelin (1, 3b-friedelinol (2, 28-hydroxyfriedelin (3, 16a-hydroxyfriedelin (4, 30-hydroxyfriedelin (5 and 16a,28-dihydroxyfriedelin (6 were isolated through fractionation of the hexane extract obtained from branches of Salacia elliptica. After a week in CDCl3 solution, 16a-hydroxyfriedelin (4 reacted turning into 3-oxo-16-methylfriedel-16-ene (7. This is the first report of a dehydration followed by a Nametkin rearrangement of a pentacyclic triterpene in CDCl3 solution occurring in the NMR tube. These seven pentacyclic triterpenes was identified through NMR spectroscopy and the stereochemistry of compound 4 and 7 was established by 2D NMR (NOESY spectroscopy and mass spectrometry (GC-MS. It is also the first time that all the 13C-NMR and 2D NMR spectral data are reported for compounds 4 and 7.

  4. A practical synthesis of long-chain iso-fatty acids (iso-C12–C19 and related natural products

    Directory of Open Access Journals (Sweden)

    Mark B. Richardson

    2013-09-01

    Full Text Available A gram-scale synthesis of terminally-branched iso-fatty acids (iso-C12–C19 was developed commencing with methyl undec-10-enoate (methyl undecylenate (for iso-C12–C14 or the C15 and C16 lactones pentadecanolide (for iso-C15–C17 and hexadecanolide (for iso-C18–C19. Central to the approaches outlined is the two-step construction of the terminal isopropyl group through addition of methylmagnesium bromide to the ester/lactones and selective reduction of the resulting tertiary alcohols. Thus, the C12, C17 and C18 iso-fatty acids were obtained in three steps from commercially-available starting materials, and the remaining C13–C16 and C19 iso-fatty acids were prepared by homologation or recursive dehomologations of these fatty acids or through intercepting appropriate intermediates. Highlighting the synthetic potential of the iso-fatty acids and various intermediates prepared herein, we describe the synthesis of the natural products (S-2,15-dimethylpalmitic acid, (S-2-hydroxy-15-methylpalmitic acid, and 2-oxo-14-methylpentadecane.

  5. Comparing Written and Planned Training On Anxiety among Patients Undergoing Orthopedic Surgery

    Directory of Open Access Journals (Sweden)

    maryam tolyat

    2017-03-01

    Full Text Available Introduction and objectives: The prevalence of preoperative state anxiety is an unavoidable complication. Aside from its type and scope, the surgical operation is considered as a severe stressful situation for patients. Considering the importance of reducing the state anxiety in patients undergoing surgery, there are different methods, one of which is patient education; therefore the aim of the current study was compare the effect of written and planned training on the state anxiety among patients undergoing orthopedic surgery. Method: In this study, 81 patients candidate for orthopedic surgery were selected using convenience sampling and were randomly divided into 3 groups, including planned training, pamphlet and control groups. All patients answered 20 questions-State-Traits Anxiety Inventory (STAI Questionnaire the day before surgery and the intervention was later carried out in the planned training and pamphlet groups. Then the effect of preoperative state anxiety was re-evaluated about half an hour after training in three groups. For data analysis, in addition to mean and standard deviation, independent t-test and ANOVA were used in Spss16. Results: The results of comparing pre- and post-training mean score of the state anxiety in three groups showed that the mean score of state anxiety reached from 50.41 to 41.03, 52.41 to 44.37 and 45.04 to 50.56 in planned, pamphlet and control groups, respectively. ANOVA test showed that there is a significant difference in this comparison. The results of Tukey's test also revealed that the mean score of state anxiety in the planned and pamphlet groups was lower significantly than the control group (p<0.05. Conclusion: Based on research findings, the planned training method was more effective in decreasing state anxiety among patients compared to the pamphlet group before orthopedic surgery. Therefore, considering the fact that nurses play an important role in examining and relieving the state anxiety

  6. Predictors of Glycemic Control in Adolescents of Various Age Groups With Type 1 Diabetes.

    Science.gov (United States)

    Lee, Shu-Li; Lo, Fu-Sung; Lee, Yann-Jinn; Chen, Bai-Hsiun; Wang, Ruey-Hsia

    2015-12-01

    Understanding the predictors of glycemic control in adolescents of various age groups with type 1 diabetes (T1D) is crucial for nurses to cultivate developmental-specific interventions to improve glycemic control in this age group. However, research has rarely addressed this issue, particularly in the context of Asian populations. We explored the predictive influence of demographic characteristics, self-care behaviors, family conflict, and parental involvement on glycosylated hemoglobin (HbA1C) levels 6 months after the baseline measurement in adolescents of various age groups with T1D in Taiwan. A prospective survey design was applied. At baseline, adolescents with T1D completed a self-care behavior scale. Parents or guardians finished scales of parental involvement and family conflict. The HbA1C levels 6 months after baseline measurement were collected from medical records. Two hundred ten adolescent-parent/guardian pairs were enrolled as participants. Multiple stepwise regressions examined the significant predictors of HbA1C levels 6 months after the baseline measurement in the three adolescent age groups: 10-12, 13-15, and 16-18 years. Family conflict was a significant predictor of HbA1C level within the 10-12 years of age group 6 months after the baseline measurement. Self-care behaviors were a significant predictor of HbA1C level within the 13-15 years of age group 6 months after the baseline measurement. Being female and self-care behaviors were each significant predictors of HbA1C level in the 16-18 years of age group 6 months after the baseline measurement. Nurses should design specific interventions to improve glycemic control in adolescents of various age groups with T1D that are tailored to their developmental needs. For adolescents with T1D aged 10-12 years, nurses should actively assess family conflict and provide necessary interventions. For adolescents with T1D aged 13-18 years, nurses should exert special efforts to improve their self

  7. A study of the reactions 14C( vector d, dprime)14C and 14C ( vector d, p)15C at 16.0 MeV

    International Nuclear Information System (INIS)

    Murillo, G.; Sen, S.; Darden, S.E.

    1994-01-01

    Cross-section and vector-analyzing-power measurements for 14 C(d, d prime) and 14 C(d, p) reactions have been carried out for E d =16 MeV. The inelastic-scattering data have been analyzed using the DWBA with a collective and a microscopic model form-factor and also by using the coupled-channels formalism with a vibrational model form-factor. It is observed that while the cross-section angular-distribution data for the two 2 + states at E x =7.012 and 8.318 MeV are very similar, the corresponding vector analyzing powers are quite different. The results of the analyses indicate that the distinctive characteristics probably arise from the difference in the relative importance of the proton and neutron components in the transition amplitude. The 3 - state at E x =6.728 MeV is identified as predominantly a 1p-3h state. Although the deformation parameters are relatively large, the single-particle structure aspects play a more dominant role than channel-coupling effects in populating the inelastic states. The transfer reaction data have been analyzed using the DWBA for bound and unbound states. The importance of two-step processes has been investigated via coupled-reaction-channels calculations. The g.s. and the states with excitation energies 0.770, 3.103 and 4.78 MeV in 15 C are populated primarily by a one-step process with a small two-step contribution in the case of the 3.103 MeV state. The 4.22 MeV state is populated predominantly by two-step processes. The 4.78 and the 5.83 MeV states have been identified as 1p-2h and 3p-4h, [3]/[2] + state, respectively, in an earlier report. There is close similarity in the level structures and reaction mechanisms between the states of 15 C and 17 O populated via the (d, p) reaction. ((orig.))

  8. Direct 13C-1H coupling constants in the vinyl group of 1-vinylpyrazoles

    International Nuclear Information System (INIS)

    Afonin, A.V.; Voronov, V.K.; Es'kova, L.A.; Domnina, E.S.; Petrova, E.V.; Zasyad'ko, O.V.

    1987-01-01

    In a continuation of a study of the rotational isomerism of 1-vinylpyrazoles, they studied the direct 13 C- 1 H coupling constants in the vinyl group of 1-vinylpyrazole, 1-vinyl-4-bromopyrazole, 1-vinyl-3-methylpyrazole, 1-vinyl-5-methylpyrazole, 1-vinyl-3,5-dimethylpyrazole, and 1-vinyl-4-nitro-3,5-dimethylpyrazole. The 13 C- 1 H direct coupling constants in the vinyl group of 1-vinylpyrazoles are stereo-specific and vary with change in the conformer ratio

  9. On the mechanical stability of the body-centered cubic phase and the emergence of a metastable cI16 phase in classical hard sphere solids

    Science.gov (United States)

    Warshavsky, Vadim B.; Ford, David M.; Monson, Peter A.

    2018-01-01

    The stability of the body-centered cubic (bcc) solid phase of classical hard spheres is of intrinsic interest and is also relevant to the development of perturbation theories for bcc solids of other model systems. Using canonical ensemble Monte Carlo, we simulated systems initialized in a perfect bcc lattice at various densities in the solid region. We observed that the systems rapidly evolved into one of four structures that then persisted for the duration of the simulation. Remarkably, one of these structures was identified as cI16, a cubic crystalline structure with 16 particles in the unit cell, which has recently been observed experimentally in lithium and sodium solids at high pressures. The other three structures do not exhibit crystalline order but are characterized by common patterns in the radial distribution function and bond-orientational order parameter distribution; we refer to them as bcc-di, with i ranging from 1 to 3. We found similar outcomes when employing any of the three single occupancy cell (SOC) restrictions commonly used in the literature. We also ran long constant-pressure simulations with box shape fluctuations initiated from bcc and cI16 initial configurations. At lower pressures, all the systems evolved to defective face-centered cubic (fcc) or hexagonal close-packed (hcp) structures. At higher pressures, most of the systems initiated as bcc evolved to cI16 with some evolving to defective fcc/hcp. High pressure systems initiated from cI16 remained in that structure. We computed the chemical potential of cI16 using the Einstein crystal reference method and found that it is higher than that of fcc by ˜0.5kT-2.5kT over the pressure range studied, with the difference increasing with pressure. We find that the undistorted bcc solid, even with constant-volume and SOC restrictions applied, is so mechanically unstable that it is unsuitable for consideration as a metastable phase or as a reference system for studying bcc phases of other systems

  10. SU-E-J-70: Feasibility Study of Dynamic Arc and IMRT Treatment Plans Utilizing Vero Treatment Unit and IPlan Planning Computer for SRS/FSRT Brain Cancer Patients

    International Nuclear Information System (INIS)

    Huh, S; Lee, S; Dagan, R; Malyapa, R; Mendenhall, N; Mendenhall, W; Ho, M; Hough, D; Yam, M; Li, Z

    2014-01-01

    Purpose: To investigate the feasibility of utilizing Dynamic Arc (DA) and IMRT with 5mm MLC leaf of VERO treatment unit for SRS/FSRT brain cancer patients with non-invasive stereotactic treatments. The DA and IMRT plans using the VERO unit (BrainLab Inc, USA) are compared with cone-based planning and proton plans to evaluate their dosimetric advantages. Methods: The Vero treatment has unique features like no rotational or translational movements of the table during treatments, Dynamic Arc/IMRT, tracking of IR markers, limitation of Ring rotation. Accuracies of the image fusions using CBCT, orthogonal x-rays, and CT are evaluated less than ∼ 0.7mm with a custom-made target phantom with 18 hidden targets. 1mm margin is given to GTV to determine PTV for planning constraints considering all the uncertainties of planning computer and mechanical uncertainties of the treatment unit. Also, double-scattering proton plans with 6F to 9F beams and typical clinical parameters, multiple isocenter plans with 6 to 21 isocenters, and DA/IMRT plans are evaluated to investigate the dosimetric advantages of the DA/IMRT for complex shape of targets. Results: 3 Groups of the patients are divided: (1) Group A (complex target shape), CI's are same for IMRT, and DGI of the proton plan are better by 9.5% than that of the IMRT, (2) Group B, CI of the DA plans (1.91+/−0.4) are better than cone-based plan, while DGI of the DA plan is 4.60+/−1.1 is better than cone-based plan (5.32+/−1.4), (3) Group C (small spherical targets), CI of the DA and cone-based plans are almost the same. Conclusion: For small spherical targets, cone-based plans are superior to other 2 plans: DS proton and DA plans. For complex or irregular plans, dynamic and IMRT plans are comparable to cone-based and proton plans for complex targets

  11. Application programming in C# environment with recorded user software interactions and its application in autopilot of VMAT/IMRT treatment planning.

    Science.gov (United States)

    Wang, Henry; Xing, Lei

    2016-11-08

    An autopilot scheme of volumetric-modulated arc therapy (VMAT)/intensity-modulated radiation therapy (IMRT) planning with the guidance of prior knowl-edge is established with recorded interactions between a planner and a commercial treatment planning system (TPS). Microsoft (MS) Visual Studio Coded UI is applied to record some common planner-TPS interactions as subroutines. The TPS used in this study is a Windows-based Eclipse system. The interactions of our application program with Eclipse TPS are realized through a series of subrou-tines obtained by prerecording the mouse clicks or keyboard strokes of a planner in operating the TPS. A strategy to autopilot Eclipse VMAT/IMRT plan selection process is developed as a specific example of the proposed "scripting" method. The autopiloted planning is navigated by a decision function constructed with a reference plan that has the same prescription and similar anatomy with the case at hand. The calculation proceeds by alternating between the Eclipse optimization and the outer-loop optimization independent of the Eclipse. In the C# program, the dosimetric characteristics of a reference treatment plan are used to assess and modify the Eclipse planning parameters and to guide the search for a clinically sensible treatment plan. The approach is applied to plan a head and neck (HN) VMAT case and a prostate IMRT case. Our study demonstrated the feasibility of application programming method in C# environment with recorded interactions of planner-TPS. The process mimics a planner's planning process and automatically provides clinically sensible treatment plans that would otherwise require a large amount of manual trial and error of a planner. The proposed technique enables us to harness a commercial TPS by application programming via the use of recorded human computer interactions and provides an effective tool to greatly facilitate the treatment planning process. © 2016 The Authors.

  12. 31 CFR 16.21 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Discovery. 16.21 Section 16.21 Money... FRAUD CIVIL REMEDIES ACT OF 1986 § 16.21 Discovery. (a) The following types of discovery are authorized... to require the creation of a document. (c) Unless mutually agreed to by the parties, discovery is...

  13. Structure of a Class I Tagatose-1,6-bisphosphate Aldolase - Investigation into an Apparent Loss of Stereospecificity

    Energy Technology Data Exchange (ETDEWEB)

    LowKam, C.; Liotard, B; Sygusch, J

    2010-01-01

    Tagatose-1,6-bisphosphate aldolase from Streptococcus pyogenes is a class I aldolase that exhibits a remarkable lack of chiral discrimination with respect to the configuration of hydroxyl groups at both C3 and C4 positions. The enzyme catalyzes the reversible cleavage of four diastereoisomers (fructose 1,6-bisphosphate (FBP), psicose 1,6-bisphosphate, sorbose 1,6-bisphosphate, and tagatose 1,6-bisphosphate) to dihydroxyacetone phosphate (DHAP) and d-glyceraldehyde 3-phosphate with high catalytic efficiency. To investigate its enzymatic mechanism, high resolution crystal structures were determined of both native enzyme and native enzyme in complex with dihydroxyacetone-P. The electron density map revealed a ({alpha}/{beta}){sub 8} fold in each dimeric subunit. Flash-cooled crystals of native enzyme soaked with dihydroxyacetone phosphate trapped a covalent intermediate with carbanionic character at Lys{sup 205}, different from the enamine mesomer bound in stereospecific class I FBP aldolase. Structural analysis indicates extensive active site conservation with respect to class I FBP aldolases, including conserved conformational responses to DHAP binding and conserved stereospecific proton transfer at the DHAP C3 carbon mediated by a proximal water molecule. Exchange reactions with tritiated water and tritium-labeled DHAP at C3 hydrogen were carried out in both solution and crystalline state to assess stereochemical control at C3. The kinetic studies show labeling at both pro-R and pro-S C3 positions of DHAP yet detritiation only at the C3 pro-S-labeled position. Detritiation of the C3 pro-R label was not detected and is consistent with preferential cis-trans isomerism about the C2-C3 bond in the carbanion as the mechanism responsible for C3 epimerization in tagatose-1,6-bisphosphate aldolase.

  14. 75 FR 70114 - Amendment to the Interim Final Rules for Group Health Plans and Health Insurance Coverage...

    Science.gov (United States)

    2010-11-17

    ... HEALTH AND HUMAN SERVICES Office of Consumer Information and Insurance Oversight 45 CFR Part 147 RIN 0950-AA17 [OCIIO-9991-IFC2] Amendment to the Interim Final Rules for Group Health Plans and Health Insurance... Administration, Department of Labor; Office of Consumer Information and Insurance Oversight, Department of Health...

  15. Environmental change during the last glacial maximum (c. 25,000-16,500 years BP) at Mt Richmond, Auckland Isthmus, New Zealand

    International Nuclear Information System (INIS)

    Sandiford, A.; Horrocks, M.; Newnham, R.; Ogden, J.; Alloway, B.V.

    2002-01-01

    A 2 m section at the base of Mt Richmond contains a palynological record of the last glacial maximum (LGM) (c. 25,000-c. 16,500 14 C years BP) vegetation of the Auckland Isthmus. Three silicic tephra layers derived from the Taupo Volcanic Centre (Okaia Tephra c. 23,500 14 C years BP, Kawakawa Tephra c. 22,500 14 C years BP) and the Okataina Volcanic Centre (Okareka Tephra c. 18,000 14 C years BP), both centres lying within the Taupo Volcanic Zone, provide the basis of the chronology supported by radiocarbon dates. The pollen diagram is divided into two pollen zones separated by the deposition of a locally derived basaltic ash. From c. 25,000-23,000 14 C years BP the site was initially a eutrophic lake fringed by Leptospermum and Typha, which altered to a Cyperaceae/Leptospermum-dominated swamp. The regional vegetation at the time was beech-dominated forest; canopy conifers were present but formed a minor part of the local forest. From c. 23,000-16,500 14 C years BP regional forest was further restricted to local patches in extensive shrubland/grassland. Temperatures may have been depressed by more than 4-5 degrees C. The eruption of a local volcano dammed the swamp outlet resulting in a return to lacustrine conditions. Local volcanism may have accelerated vegetation change already under way as a result of climate change to cooler conditions. This record provides a view of LGM vegetation of the Auckland Isthmus and a template for earlier cold stages of the Quaternary. (author). 39 refs., 3 figs., 1 tab

  16. 30 CFR 925.25 - Approval of Missouri abandoned mine land reclamation plan amendments.

    Science.gov (United States)

    2010-07-01

    ... publication Citation/description June 22, 1987 June 16, 1988 10 CSR 40-9.060(2), (3), (4). August 22, 1988...; land acquisition, management and disposal; database. November 29, 1994 August 24, 1995 RSMo 444.810.2 through .8; 444.915.3; 10 CSR 40-9.020(1)(D), (E), (3)(A); AML Plan § 884.13(C)(2), (D)(3), (4). March 31...

  17. The establishment of master plan for developing advanced I and C technology -The development of advanced instrumentation and control technology-

    International Nuclear Information System (INIS)

    Ham, Chang Shik; Lee, Byung Sun; Kwon, Kee Choon; Lee, Dong Young; Hwang, In Koo; Lee, Jang Soo; Kim, Jung Soo; Kim, Chang Hwoi; Jung, Chul Hwan; Na, Nan Ju; Dong, In Sook; Kang, Soon Gu; Lyu, Chan Ho; Song, Soon Ja

    1994-07-01

    Although several organizations are performing their tasks making efforts to develop new digital technology for application to existing nuclear power plants as well as new plants of the future, their projects are similar to each other and have possibilities of redundant investment. Therefore, KAERI have established a Master Plan to define the suitable work-scope of each Instrumentation and Control (I and C) development project and proceed its development items continuously. Furthermore, in the project, several kinds of advanced technology for application of computer science and digital electronics were studied to obtain better reliability of the I and C systems and reduce opertor's burden. For establishing the Master Plan, functions of I and C system of NPPs were surveyed. Especially EPRI URD was deeply analyzed for setting up a basis of the foreign countries were referred for the Master Plan. For the new technology survey, fault-tolerant control technology and control system performance analysis methods were studied. Requirements of alarm and information system as well as technology of I and C network system of NPPs were also established to introduce the advantages of commercial distributed control system. (Author)

  18. ON THE MEASUREMENT OF THE {sup 13}C(α, n){sup 16}O S-FACTOR AT NEGATIVE ENERGIES AND ITS INFLUENCE ON THE s-PROCESS

    Energy Technology Data Exchange (ETDEWEB)

    La Cognata, M.; Spitaleri, C.; Trippella, O.; Kiss, G. G.; Guardo, G. L.; Puglia, S. M. R.; Romano, S.; Spartà, R. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, I-95123, Catania (Italy); Rogachev, G. V.; Avila, M.; Koshchiy, E.; Kuchera, A.; Santiago, D. [Department of Physics, Florida State University, Tallahassee, FL (United States); Mukhamedzhanov, A. M. [Cyclotron Institute, Texas A and M University, College Station, TX (United States); Lamia, L., E-mail: lacognata@lns.infn.it [Dipartimento di Fisica e Astronomia, Università di Catania, I-95123 Catania (Italy)

    2013-11-10

    The {sup 13}C(α, n){sup 16}O reaction is the neutron source for the main component of the s-process, responsible for the production of most of the nuclei in the mass range 90 ∼< A ∼< 208. This reaction takes place inside the helium-burning shell of asymptotic giant branch stars, at temperatures ∼< 10{sup 8} K, corresponding to an energy interval where the {sup 13}C(α, n){sup 16}O reaction is effective in the range of 140-230 keV. In this regime, the astrophysical S(E)-factor is dominated by the –3 keV sub-threshold resonance due to the 6.356 MeV level in {sup 17}O, giving rise to a steep increase in the S-factor. Its contribution is still controversial as extrapolations, e.g., through the R-matrix and indirect techniques such as the asymptotic normalization coefficient (ANC), yield inconsistent results. The discrepancy amounts to a factor of three or more precisely at astrophysical energies. To provide a more accurate S-factor at these energies, we have applied the Trojan horse method (THM) to the {sup 13}C({sup 6}Li, n {sup 16}O)d quasi-free reaction. The ANC for the 6.356 MeV level has been deduced through the THM as well as the n-partial width, allowing us to attain unprecedented accuracy for the {sup 13}C(α, n){sup 16}O astrophysical factor. A larger ANC for the 6.356 MeV level is measured with respect to the ones in the literature, (C-tilde{sub α{sup 1}{sup 3}C}{sup 17O(1/2+)2} = 7.7 ± 0.3{sub stat} {sub -1.5}{sup +1.}|6 norm fm{sup –1}, yet in agreement with the preliminary result given in our preceding letter, indicating an increase of the {sup 13}C(α, n){sup 16}O reaction rate below about 8 × 10{sup 7} K if compared with the recommended values. At ∼10{sup 8} K, our reaction rate agrees with most of the results in the literature and the accuracy is greatly enhanced thanks to this innovative approach.

  19. Hazardous Waste Development, Demonstration, and Disposal (HAZWDDD) Program Plan

    International Nuclear Information System (INIS)

    McGinnis, C.P.; Eisenhower, B.M.; Reeves, M.E.; DePaoli, S.M.; Stinton, L.H.; Harrington, E.H.

    1989-02-01

    The objective of the Hazardous Waste Development, Demonstration and Disposal (HAZWDDD) Program Plan is to ensure that the needs for treatment and disposal of all its hazardous and mixed wastes have been identified and planned for. A multifaceted approach to developing and implementing this plan is given, including complete plans for each of the five installations, and an overall integrated plan is also described in this report. The HAZWDDD Plan accomplishes the following: (1) provides background and organizational information; (2) summarizes the 402 hazardous and mixed waste streams from the five installations by grouping them into 13 general waste categories; (3) presents current treatment, storage, and disposal capabilities within Energy Systems; (4) develops a management strategy by outlining critical issues, presents flow sheets describing management schemes for problem waste streams, and builds on the needs identified; (5) outlines specific activities needed to implement the strategy developed; and (6) presents schedule and budget requirements for the next decade. The HAZWDDD Program addresses current and future technical problems and regulatory issues and uncertainties. Because of the nature and magnitude of the problems in hazardous and mixed waste management, substantial funding will be required. 10 refs., 39 figs., 16 tabs

  20. Subthreshold pion production of 20-100 MeV energy with various projectiles (p, 3He, 12C, 16O)

    International Nuclear Information System (INIS)

    Sanouillet, G.; Bolore, M.; Charlot, X.

    1986-05-01

    The described experiments refer to pion production below and near the threshold with different projectiles (p, 3 He, 12 C, 16 O). The pion detection device was a range telescope. Experimental methods are presented and discussed. Data are compared to predictions of some models [fr